Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000624-TA|BGIBMGA000624-PA|IPR001452|Src homology-3,
IPR003599|Immunoglobulin subtype, IPR003598|Immunoglobulin subtype 2,
IPR003961|Fibronectin, type III, IPR003962|Fibronectin, type III
subdomain, IPR007110|Immunoglobulin-like, IPR013098|Immunoglobulin
I-set, IPR008957|Fibronectin, type III-like fold
(2130 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein. 299 9e-80
AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein. 299 9e-80
X90568-1|CAA62188.1|26926|Homo sapiens titin protein. 298 1e-79
X90569-1|CAA62189.1| 7962|Homo sapiens elastic titin protein. 263 6e-69
X69490-1|CAA49245.1| 4650|Homo sapiens titin protein. 252 1e-65
X64697-1|CAA45938.1| 3100|Homo sapiens titin protein. 252 1e-65
X73114-1|CAA51545.1| 1123|Homo sapiens slow MyBP-C protein. 238 2e-61
BC117217-1|AAI17218.1| 1120|Homo sapiens MYBPC1 protein protein. 238 2e-61
BC092418-1|AAH92418.1| 1123|Homo sapiens myosin binding protein ... 238 2e-61
BX928748-1|CAH74051.1| 5635|Homo sapiens protein ( Human DNA seq... 235 2e-60
AL391824-1|CAI17865.1| 5635|Homo sapiens protein ( Human DNA seq... 235 2e-60
AL135797-1|CAI17871.1| 5635|Homo sapiens protein ( Human DNA seq... 235 2e-60
AL135796-1|CAI17854.1| 5635|Homo sapiens protein ( Human DNA seq... 235 2e-60
AL133553-2|CAI17858.1| 5635|Homo sapiens protein ( Human DNA seq... 235 2e-60
AL133515-1|CAI17853.1| 5635|Homo sapiens protein ( Human DNA seq... 235 2e-60
AL121996-1|CAI17844.1| 5635|Homo sapiens protein ( Human DNA seq... 235 2e-60
AL118512-1|CAI17864.1| 5635|Homo sapiens protein ( Human DNA seq... 235 2e-60
AF156100-1|AAK68690.1| 5636|Homo sapiens hemicentin protein. 233 4e-60
X73113-1|CAA51544.1| 1142|Homo sapiens fast MyBP-C protein. 231 3e-59
BC130536-1|AAI30537.1| 1141|Homo sapiens myosin binding protein ... 231 3e-59
AK056557-1|BAB71216.1| 1252|Homo sapiens protein ( Homo sapiens ... 217 4e-55
X64698-1|CAA45939.1| 1100|Homo sapiens titin protein. 214 3e-54
DQ248309-1|ABB55264.1| 851|Homo sapiens rhabdomyosarcoma antige... 202 1e-50
BC115397-1|AAI15398.1| 867|Homo sapiens IGSF22 protein protein. 196 5e-49
AL670729-3|CAH71673.1| 6620|Homo sapiens obscurin, cytoskeletal ... 192 2e-47
AL359510-13|CAI15072.1| 6620|Homo sapiens obscurin, cytoskeletal... 192 2e-47
AL353593-3|CAI19285.1| 6620|Homo sapiens obscurin, cytoskeletal ... 192 2e-47
AJ002535-1|CAC44768.1| 6620|Homo sapiens obscurin protein. 192 2e-47
AJ314905-1|CAC85752.1| 2212|Homo sapiens obscurin protein. 184 2e-45
AB046776-1|BAB13382.1| 1596|Homo sapiens KIAA1556 protein protein. 184 2e-45
AK095113-1|BAC04488.1| 903|Homo sapiens protein ( Homo sapiens ... 182 9e-45
AJ306906-1|CAC37630.1| 2673|Homo sapiens fibulin-6 protein. 181 2e-44
AJ277892-3|CAD12457.1| 5604|Homo sapiens Novex-3 Titin Isoform p... 181 3e-44
AC023270-1|AAX88844.1| 5604|Homo sapiens unknown protein. 181 3e-44
AJ277892-5|CAD12459.1| 2154|Homo sapiens Titin Novex-1 Isoform p... 179 9e-44
AJ277892-4|CAD12458.1| 1294|Homo sapiens Titin Novex-2 Isoform p... 179 9e-44
AB209136-1|BAD92373.1| 2023|Homo sapiens Down syndrome cell adhe... 169 7e-41
AF217525-1|AAF27525.1| 2012|Homo sapiens Down syndrome cell adhe... 169 1e-40
AF023450-1|AAC17967.1| 1571|Homo sapiens Down syndrome cell adhe... 169 1e-40
AF023449-1|AAC17966.1| 1896|Homo sapiens Down syndrome cell adhe... 169 1e-40
AF289030-1|AAL56711.1| 1746|Homo sapiens Down syndrome cell adhe... 162 1e-38
X66276-1|CAA46987.1| 1138|Homo sapiens C protein protein. 161 2e-38
BC131529-1|AAI31530.1| 868|Homo sapiens eEF1A2 binding protein ... 157 3e-37
AY245430-1|AAO92932.1| 868|Homo sapiens eEF1A2 binding protein ... 157 3e-37
AL834139-1|CAD38854.1| 1340|Homo sapiens hypothetical protein pr... 150 5e-35
EF063638-1|ABO42328.1| 1896|Homo sapiens obscurin-like 1 isoform... 149 8e-35
EF063637-1|ABO42327.1| 1544|Homo sapiens obscurin-like 1 isoform... 149 1e-34
X64699-1|CAA45940.1| 531|Homo sapiens titin protein. 148 2e-34
BC007201-1|AAH07201.1| 1044|Homo sapiens OBSL1 protein protein. 147 4e-34
AL832379-1|CAD91155.1| 1045|Homo sapiens hypothetical protein pr... 146 6e-34
AL832002-1|CAD89906.1| 1320|Homo sapiens hypothetical protein pr... 146 6e-34
AL512429-2|CAH73748.1| 1320|Homo sapiens sarcomeric protein myop... 146 6e-34
AL512429-1|CAH73747.1| 1045|Homo sapiens sarcomeric protein myop... 146 6e-34
AF328296-1|AAK50625.1| 1320|Homo sapiens myopalladin protein. 146 6e-34
AL834247-1|CAD38923.2| 1391|Homo sapiens hypothetical protein pr... 145 2e-33
BC052969-1|AAH52969.1| 1465|Homo sapiens myomesin (M-protein) 2,... 144 3e-33
X69089-1|CAA48832.1| 1465|Homo sapiens 165kD protein protein. 144 4e-33
Y10129-1|CAA71216.1| 1274|Homo sapiens myosin binding protein C ... 139 9e-32
X84075-1|CAA58882.1| 1274|Homo sapiens cardiac myosin-binding pr... 139 9e-32
X69090-1|CAA48833.1| 1451|Homo sapiens 190kD protein protein. 139 9e-32
U91629-1|AAC04620.1| 1274|Homo sapiens cardiac myosin binding pr... 139 1e-31
BC116183-1|AAI16184.1| 1589|Homo sapiens myomesin 1, 185kDa prot... 139 1e-31
AY518390-1|AAR89909.1| 1273|Homo sapiens myosin binding protein ... 139 1e-31
BC043916-1|AAH43916.1| 767|Homo sapiens OBSCN protein protein. 138 2e-31
AL353593-1|CAI19283.1| 709|Homo sapiens obscurin, cytoskeletal ... 138 2e-31
AJ314900-1|CAC85747.1| 551|Homo sapiens obscurin protein. 137 4e-31
AB014557-1|BAA31632.2| 1237|Homo sapiens KIAA0657 protein protein. 136 8e-31
AY339601-1|AAQ02673.1| 1914|Homo sapiens long myosin light chain... 136 1e-30
U48959-1|AAC18423.2| 1914|Homo sapiens myosin light chain kinase... 135 1e-30
AF069602-1|AAD15922.1| 1862|Homo sapiens myosin light chain kina... 135 1e-30
AY424270-1|AAR29062.1| 1914|Homo sapiens myosin lignt chain poly... 134 4e-30
AF491813-1|AAM09558.1| 2113|Homo sapiens Down syndrome cell adhe... 130 5e-29
AF334384-1|AAL57166.1| 2053|Homo sapiens Down syndrome cell adhe... 130 5e-29
AB032958-1|BAA86446.2| 2092|Homo sapiens KIAA1132 protein protein. 130 5e-29
AL353593-2|CAI19284.1| 416|Homo sapiens obscurin, cytoskeletal ... 129 9e-29
AJ314903-1|CAC85750.1| 542|Homo sapiens obscurin protein. 128 2e-28
BC048768-1|AAH48768.1| 1898|Homo sapiens protein tyrosine phosph... 128 3e-28
AL583862-9|CAI14895.1| 1898|Homo sapiens protein tyrosine phosph... 128 3e-28
AB177857-1|BAD66835.1| 1918|Homo sapiens LAR protein. 128 3e-28
BC106713-1|AAI06714.1| 1505|Homo sapiens PTPRD protein protein. 127 4e-28
BC013867-1|AAH13867.2| 510|Homo sapiens PALLD protein protein. 127 5e-28
AF464873-1|AAL69964.1| 1106|Homo sapiens myoneurin protein. 127 5e-28
AB023209-1|BAA76836.1| 772|Homo sapiens KIAA0992 protein protein. 127 5e-28
AF304304-1|AAN32613.1| 2053|Homo sapiens Down syndrome cell adhe... 126 9e-28
BC117674-1|AAI17675.2| 1240|Homo sapiens NFASC protein protein. 126 1e-27
AL391822-8|CAI14664.1| 1040|Homo sapiens neurofascin homolog (ch... 126 1e-27
AL391822-7|CAI14662.1| 1165|Homo sapiens neurofascin homolog (ch... 126 1e-27
AL391822-6|CAI14661.1| 1157|Homo sapiens neurofascin homolog (ch... 126 1e-27
AL391822-5|CAI14659.1| 1240|Homo sapiens neurofascin homolog (ch... 126 1e-27
AL391822-4|CAI14660.1| 1347|Homo sapiens neurofascin homolog (ch... 126 1e-27
AL391822-3|CAI14658.1| 1174|Homo sapiens neurofascin homolog (ch... 126 1e-27
AL391822-2|CAI14657.1| 619|Homo sapiens neurofascin homolog (ch... 126 1e-27
AB177861-1|BAD66839.1| 836|Homo sapiens KIAA0756 splice variant... 126 1e-27
AB018299-1|BAA34476.3| 1222|Homo sapiens KIAA0756 protein protein. 126 1e-27
AF151909-1|AAD34146.1| 404|Homo sapiens CGI-151 protein protein. 124 4e-27
AL713647-1|CAD28458.1| 1232|Homo sapiens hypothetical protein pr... 123 6e-27
Y00815-1|CAA68754.1| 1897|Homo sapiens put. LAR preprotein (AA -... 123 8e-27
AL163282-1|CAB90436.1| 812|Homo sapiens human CHD2-52 down synd... 123 8e-27
AL583862-10|CAI14894.1| 1907|Homo sapiens protein tyrosine phosp... 122 1e-26
U72391-1|AAC51287.1| 1461|Homo sapiens neogenin protein. 122 1e-26
U61262-1|AAB17263.1| 1461|Homo sapiens neogenin protein. 122 1e-26
BC117161-1|AAI17162.1| 1461|Homo sapiens neogenin homolog 1 (chi... 122 1e-26
AF304305-1|AAN32614.1| 1842|Homo sapiens Down syndrome cell adhe... 121 3e-26
AY273815-1|AAQ16156.1| 2623|Homo sapiens bone specific CMF608 pr... 120 6e-26
AK075220-1|BAC11480.1| 760|Homo sapiens protein ( Homo sapiens ... 119 1e-25
AK223599-1|BAD97319.1| 1204|Homo sapiens factor for adipocyte di... 118 2e-25
BC033635-1|AAH33635.1| 753|Homo sapiens FNDC3B protein protein. 117 4e-25
AY358146-1|AAQ88513.1| 847|Homo sapiens YVTM2421 protein. 117 4e-25
BC039297-1|AAH39297.1| 1204|Homo sapiens fibronectin type III do... 117 5e-25
BC132812-1|AAI32813.1| 1198|Homo sapiens FNDC3A protein protein. 115 2e-24
BC070072-1|AAH70072.1| 853|Homo sapiens FNDC3A protein protein. 115 2e-24
BC060816-1|AAH60816.1| 853|Homo sapiens FNDC3A protein protein. 115 2e-24
AL137000-1|CAI39726.2| 1142|Homo sapiens fibronectin type III do... 115 2e-24
AJ749707-1|CAG44603.1| 1134|Homo sapiens human gene expressed in... 115 2e-24
AJ749706-1|CAG44602.1| 1198|Homo sapiens human gene expressed in... 115 2e-24
AB023187-1|BAA76814.2| 1151|Homo sapiens KIAA0970 protein protein. 115 2e-24
AB098597-1|BAC53727.1| 1204|Homo sapiens FAD104 protein. 115 2e-24
AB209851-1|BAD93088.1| 2331|Homo sapiens Basement membrane-speci... 114 4e-24
M85289-1|AAA52700.1| 4391|Homo sapiens heparan sulfate proteogly... 113 7e-24
AL590556-2|CAH71870.1| 4391|Homo sapiens heparan sulfate proteog... 113 7e-24
AL590103-2|CAI12125.1| 4391|Homo sapiens heparan sulfate proteog... 113 7e-24
AL445795-1|CAC18534.1| 4370|Homo sapiens heparan sulfate proteog... 113 7e-24
AJ314904-1|CAC85751.1| 658|Homo sapiens obscurin protein. 112 1e-23
U35234-1|AAC50299.1| 1948|Homo sapiens protein tyrosine phosphat... 111 3e-23
X62515-1|CAA44373.1| 4393|Homo sapiens Human basement membrane h... 110 5e-23
AK129856-1|BAC85243.1| 295|Homo sapiens protein ( Homo sapiens ... 109 1e-22
X76132-1|CAA53735.1| 1447|Homo sapiens tumour suppressor protein. 108 2e-22
AB211400-1|BAE79816.1| 1912|Homo sapiens protein tyrosine phosph... 108 2e-22
L38929-1|AAC41749.1| 1912|Homo sapiens protein tyrosine phosphat... 107 3e-22
AL590397-1|CAH73128.2| 1912|Homo sapiens protein tyrosine phosph... 107 3e-22
AL583805-2|CAH70443.2| 1912|Homo sapiens protein tyrosine phosph... 107 3e-22
AL445926-1|CAH73847.2| 1912|Homo sapiens protein tyrosine phosph... 107 3e-22
AL356584-1|CAI16146.2| 1912|Homo sapiens protein tyrosine phosph... 107 3e-22
AL137125-1|CAH70912.2| 1912|Homo sapiens protein tyrosine phosph... 107 3e-22
BC130619-1|AAI30620.1| 1100|Homo sapiens CNTN5 protein protein. 107 4e-22
AB013803-1|BAA36580.2| 1026|Homo sapiens hNB-2s protein. 107 4e-22
AB013802-1|BAA36579.2| 1100|Homo sapiens hNB-2 protein. 107 4e-22
BC067101-1|AAH67101.1| 1212|Homo sapiens MYOM3 protein protein. 107 6e-22
BC066363-1|AAH66363.1| 1805|Homo sapiens SDK2 protein protein. 106 8e-22
AB040947-1|BAA96038.1| 1598|Homo sapiens KIAA1514 protein protein. 106 8e-22
U40317-1|AAC50567.1| 1911|Homo sapiens PTPsigma protein. 106 1e-21
AY424269-1|AAR29061.1| 1845|Homo sapiens myosin light chain poly... 105 2e-21
AK056336-1|BAB71154.1| 512|Homo sapiens protein ( Homo sapiens ... 105 2e-21
AF069603-1|AAD15923.1| 1793|Homo sapiens myosin light chain kina... 105 2e-21
AF069601-1|AAD15921.2| 1845|Homo sapiens myosin light chain kina... 105 2e-21
AL591178-3|CAH72090.1| 1437|Homo sapiens myomesin family, member... 104 4e-21
BC036524-1|AAH36524.1| 772|Homo sapiens DCC protein protein. 103 5e-21
AY603755-1|AAT80901.1| 3094|Homo sapiens striated muscle prefere... 103 7e-21
BC047244-1|AAH47244.1| 858|Homo sapiens neural cell adhesion mo... 102 1e-20
AJ314906-1|CAC85753.1| 1040|Homo sapiens obscurin protein. 102 1e-20
AJ314898-1|CAC85746.1| 646|Homo sapiens obscurin protein. 102 2e-20
AK023854-1|BAB14704.1| 442|Homo sapiens .117). protein. 100 5e-20
AY090737-1|AAM00025.1| 1026|Homo sapiens contactin 4 protein. 100 7e-20
AF549455-1|AAP05786.1| 1026|Homo sapiens BIG-2 protein. 100 7e-20
BC113118-1|AAI13119.1| 1028|Homo sapiens contactin 6 protein. 100 1e-19
BC045763-1|AAH45763.1| 1329|Homo sapiens SDK2 protein protein. 100 1e-19
AB003592-1|BAA82612.1| 1028|Homo sapiens neural adhesion molecul... 100 1e-19
BC104812-1|AAI04813.1| 1501|Homo sapiens protein tyrosine phosph... 99 2e-19
BC052946-1|AAH52946.1| 837|Homo sapiens neural cell adhesion mo... 99 2e-19
AB209333-1|BAD92570.1| 1560|Homo sapiens protein tyrosine phosph... 99 2e-19
BC132902-1|AAI32903.1| 354|Homo sapiens myosin binding protein ... 98 3e-19
BC132900-1|AAI32901.1| 354|Homo sapiens myosin binding protein ... 98 3e-19
U75330-1|AAB80803.1| 837|Homo sapiens neural cell adhesion prot... 98 3e-19
S71824-1|AAB31836.1| 848|Homo sapiens N-CAM protein. 98 3e-19
AB209443-1|BAD92680.1| 807|Homo sapiens Neural cell adhesion mo... 98 3e-19
AY310398-1|AAP75619.1| 2213|Homo sapiens sidekick-like protein 1... 97 5e-19
M32292-1|AAA35751.1| 750|Homo sapiens protein ( Human colorecta... 97 6e-19
AY509035-1|AAS91662.1| 1386|Homo sapiens roundabout-like protein... 97 6e-19
U63041-1|AAB04558.1| 848|Homo sapiens neural cell adhesion mole... 97 8e-19
AK056544-1|BAB71212.1| 1034|Homo sapiens protein ( Homo sapiens ... 97 8e-19
BC044226-1|AAH44226.1| 477|Homo sapiens myosin binding protein ... 96 1e-18
AL390252-10|CAI13179.1| 354|Homo sapiens myosin binding protein... 96 1e-18
AB037663-1|BAB21504.1| 992|Homo sapiens myosin light chain kina... 96 1e-18
BC115022-1|AAI15023.1| 1551|Homo sapiens ROBO1 protein protein. 96 1e-18
BC115020-1|AAI15021.1| 1606|Homo sapiens ROBO1 protein protein. 96 1e-18
BC112336-1|AAI12337.1| 1607|Homo sapiens ROBO1 protein protein. 96 1e-18
AF245505-1|AAF86402.1| 2828|Homo sapiens adlican protein. 96 1e-18
BC039255-1|AAH39255.1| 617|Homo sapiens CNTN5 protein protein. 95 2e-18
AY877349-1|AAX70929.1| 1463|Homo sapiens cardiac peroxidase prot... 95 2e-18
BC098401-1|AAH98401.1| 771|Homo sapiens NRCAM protein protein. 95 3e-18
BC115736-1|AAI15737.1| 1192|Homo sapiens NRCAM protein protein. 94 4e-18
BC114570-1|AAI14571.1| 1180|Homo sapiens NRCAM protein protein. 94 4e-18
AB002341-1|BAA20801.2| 1187|Homo sapiens KIAA0343 protein. 94 4e-18
U27266-1|AAB86737.1| 477|Homo sapiens myosin binding protein H ... 94 6e-18
DQ533874-1|ABF83431.1| 1378|Homo sapiens ROBO2 isoform b protein. 94 6e-18
DQ533873-1|ABF83430.1| 1394|Homo sapiens ROBO2 isoform a protein. 94 6e-18
BX538010-1|CAD97960.1| 1183|Homo sapiens hypothetical protein pr... 94 6e-18
AJ001057-1|CAA04507.1| 1299|Homo sapiens NrCAM protein protein. 94 6e-18
AF172277-2|AAF22283.1| 1236|Homo sapiens NgCAM-related related c... 94 6e-18
AF172277-1|AAF22282.1| 1308|Homo sapiens NgCAM-related related c... 94 6e-18
AB046788-1|BAB13394.1| 1380|Homo sapiens KIAA1568 protein protein. 94 6e-18
X85337-1|CAA59685.1| 991|Homo sapiens myosin light chain kinase... 93 7e-18
U41725-1|AAD09360.1| 1502|Homo sapiens PTPsigma-(brain) protein. 93 7e-18
BC113458-1|AAI13459.1| 166|Homo sapiens MYLK protein protein. 92 2e-17
BC113456-1|AAI13457.1| 167|Homo sapiens MYLK protein protein. 92 2e-17
BC100762-1|AAI00763.2| 154|Homo sapiens myosin, light chain kin... 92 2e-17
BC100761-1|AAI00762.2| 154|Homo sapiens myosin, light chain kin... 92 2e-17
AF096775-1|AAD54019.1| 154|Homo sapiens kinase-related protein ... 92 2e-17
AF096773-1|AAD54017.1| 154|Homo sapiens kinase-related protein ... 92 2e-17
BC070170-1|AAH70170.1| 637|Homo sapiens TTN protein protein. 91 3e-17
BC058824-1|AAH58824.1| 558|Homo sapiens TTN protein protein. 91 3e-17
BC013396-1|AAH13396.1| 305|Homo sapiens TTN protein protein. 91 3e-17
AC005338-1|AAC27825.1| 475|Homo sapiens PTPsigma, partial CDS p... 91 4e-17
X90870-1|CAA62378.1| 458|Homo sapiens myosin-light-chain kinase... 90 7e-17
BC107783-1|AAI07784.1| 227|Homo sapiens MYLK protein protein. 90 7e-17
BC100763-1|AAI00764.2| 153|Homo sapiens myosin, light chain kin... 90 7e-17
BC064420-1|AAH64420.2| 153|Homo sapiens myosin, light chain kin... 90 7e-17
BC017811-1|AAH17811.1| 236|Homo sapiens MYLK protein protein. 90 7e-17
AF096774-1|AAD54018.1| 153|Homo sapiens kinase-related protein ... 90 7e-17
AF096771-2|AAD51381.1| 153|Homo sapiens kinase related protein ... 90 7e-17
AF096771-1|AAD51380.1| 300|Homo sapiens smooth muscle/nonmuscle... 90 7e-17
AF040990-1|AAC39575.1| 1651|Homo sapiens roundabout 1 protein. 90 7e-17
BC065720-1|AAH65720.1| 445|Homo sapiens MYBPC1 protein protein. 90 9e-17
AF069604-1|AAD15924.1| 560|Homo sapiens myosin light chain kina... 89 1e-16
AB209412-1|BAD92649.1| 1130|Homo sapiens neogenin homolog 1 vari... 89 1e-16
AB040929-1|BAA96020.1| 920|Homo sapiens KIAA1496 protein protein. 89 1e-16
X16841-1|CAA34739.1| 761|Homo sapiens protein ( Human mRNA for ... 89 2e-16
BC005376-1|AAH05376.1| 498|Homo sapiens myotilin protein. 89 2e-16
AF144477-1|AAD44754.1| 498|Homo sapiens myotilin protein. 89 2e-16
AF133820-1|AAD29051.2| 498|Homo sapiens titin-like protein prot... 89 2e-16
L05606-1|AAA36339.1| 476|Homo sapiens protein ( Human myosin bi... 88 4e-16
AK128233-1|BAC87343.1| 1172|Homo sapiens protein ( Homo sapiens ... 88 4e-16
BC104918-1|AAI04919.1| 1208|Homo sapiens CHL1 protein protein. 87 5e-16
AB209329-1|BAD92566.1| 1210|Homo sapiens Neural cell adhesion mo... 87 5e-16
BC008124-1|AAH08124.2| 294|Homo sapiens NFASC protein protein. 87 7e-16
AK074083-1|BAB84909.1| 1471|Homo sapiens FLJ00154 protein protein. 87 7e-16
AF002246-1|AAB60937.1| 1224|Homo sapiens neural cell adhesion mo... 87 7e-16
D86983-1|BAA13219.1| 1496|Homo sapiens KIAA0230 protein. 87 9e-16
BC098579-1|AAH98579.1| 722|Homo sapiens PXDN protein protein. 87 9e-16
AK130921-1|BAC85460.1| 572|Homo sapiens protein ( Homo sapiens ... 87 9e-16
AF200348-1|AAF06354.1| 1496|Homo sapiens melanoma-associated ant... 87 9e-16
Z29373-1|CAA82564.1| 1257|Homo sapiens neural cell adhesion mole... 86 2e-15
M77640-1|AAC14352.1| 1257|Homo sapiens L1 cell adhesion molecule... 86 2e-15
M74387-1|AAA59476.1| 1253|Homo sapiens cell adhesion molecule L1... 86 2e-15
BC126229-1|AAI26230.1| 1257|Homo sapiens L1 cell adhesion molecu... 86 2e-15
AL137357-1|CAB70709.1| 1185|Homo sapiens hypothetical protein pr... 86 2e-15
AJ621424-1|CAF18565.1| 1685|Homo sapiens myomesin 1 protein. 86 2e-15
AB102653-1|BAC81122.1| 1255|Homo sapiens L1 cell adhesion molecu... 86 2e-15
AK128020-1|BAC87234.1| 595|Homo sapiens ursor. protein. 85 2e-15
BC067107-1|AAH67107.1| 814|Homo sapiens putative neuronal cell ... 85 3e-15
BC042054-1|AAH42054.1| 814|Homo sapiens putative neuronal cell ... 85 3e-15
AY358367-1|AAQ88733.1| 625|Homo sapiens YVTM2421 protein. 85 3e-15
AC007567-1|AAS07434.1| 383|Homo sapiens unknown protein. 84 5e-15
AB011422-1|BAA76314.1| 1289|Homo sapiens Trad protein. 84 5e-15
EF506611-1|ABP88252.1| 1248|Homo sapiens non-neural L1CAM protein. 83 8e-15
AK125322-1|BAC86128.1| 1685|Homo sapiens protein ( Homo sapiens ... 83 8e-15
AK074780-1|BAC11205.1| 570|Homo sapiens protein ( Homo sapiens ... 83 8e-15
U55258-1|AAC50765.1| 1299|Homo sapiens hBRAVO/Nr-CAM precursor p... 83 1e-14
AK092284-1|BAC03850.1| 885|Homo sapiens protein ( Homo sapiens ... 83 1e-14
BX537998-1|CAD97954.1| 1263|Homo sapiens hypothetical protein pr... 82 2e-14
AL163281-2|CAB90444.1| 1029|Homo sapiens human CHD2-52 down synd... 82 2e-14
Z21488-1|CAA79696.1| 1018|Homo sapiens contactin protein. 82 2e-14
U07820-1|AAA67921.1| 1007|Homo sapiens h-contactin 2 precursor p... 82 2e-14
U07819-1|AAA67920.1| 1018|Homo sapiens h-contactin 1 precursor p... 82 2e-14
AK128160-1|BAC87305.1| 632|Homo sapiens protein ( Homo sapiens ... 82 2e-14
X68274-1|CAA48335.1| 1040|Homo sapiens TAG-1/axonin-1 precursor ... 81 3e-14
X67734-1|CAA47963.1| 1040|Homo sapiens transient axonal glycopro... 81 3e-14
BC129986-1|AAI29987.1| 1040|Homo sapiens contactin 2 (axonal) pr... 81 3e-14
AY630258-1|AAU05741.1| 1150|Homo sapiens shen-dan protein. 81 3e-14
AL583832-3|CAI15288.1| 1040|Homo sapiens contactin 2 (axonal) pr... 81 3e-14
AJ314901-1|CAC85749.1| 183|Homo sapiens obscurin protein. 81 4e-14
BC026119-1|AAH26119.1| 697|Homo sapiens contactin 4 protein. 81 6e-14
X54133-1|CAA38068.1| 1523|Homo sapiens protein-tyrosine phosphat... 80 7e-14
AK093583-1|BAC04201.1| 329|Homo sapiens protein ( Homo sapiens ... 80 7e-14
BC126171-1|AAI26172.1| 1119|Homo sapiens leucine-rich repeats an... 80 1e-13
BC126169-1|AAI26170.1| 1119|Homo sapiens leucine-rich repeats an... 80 1e-13
AY730707-1|AAU44786.1| 1093|Homo sapiens leucine-rich repeat pro... 80 1e-13
AY505340-1|AAR98629.1| 1119|Homo sapiens leucine-rich and immuno... 80 1e-13
AY358295-1|AAQ88662.1| 1059|Homo sapiens SAPS287 protein. 80 1e-13
AY358288-1|AAQ88655.1| 1119|Homo sapiens SAPS287 protein. 80 1e-13
AK074921-1|BAC11295.1| 697|Homo sapiens protein ( Homo sapiens ... 80 1e-13
AF381545-1|AAK62357.1| 1093|Homo sapiens membrane glycoprotein L... 80 1e-13
AB050468-1|BAB40659.1| 1094|Homo sapiens membrane glycoprotein L... 80 1e-13
BC109098-1|AAI09099.1| 783|Homo sapiens MUSK protein protein. 79 2e-13
AK096458-1|BAC04796.1| 410|Homo sapiens protein ( Homo sapiens ... 79 2e-13
X59847-1|CAA42508.1| 1257|Homo sapiens Neural cell adhesion mole... 79 2e-13
U40271-1|AAC50484.2| 1070|Homo sapiens transmembrane receptor pr... 79 2e-13
BC071557-1|AAH71557.1| 1070|Homo sapiens PTK7 protein tyrosine k... 79 2e-13
AL355385-4|CAI13783.1| 1070|Homo sapiens PTK7 protein tyrosine k... 79 2e-13
AF531872-1|AAN04866.1| 816|Homo sapiens transmembrane receptor ... 79 2e-13
AF531868-1|AAN04862.1| 1070|Homo sapiens transmembrane receptor ... 79 2e-13
AF447176-1|AAL39062.1| 1070|Homo sapiens protein tyrosine kinase... 79 2e-13
AB209350-1|BAD92587.1| 773|Homo sapiens PTK7 protein tyrosine k... 79 2e-13
BC106715-1|AAI06716.1| 1505|Homo sapiens PTPRD protein protein. 78 3e-13
BC106714-1|AAI06715.1| 1506|Homo sapiens PTPRD protein protein. 78 3e-13
BC029119-1|AAH29119.1| 364|Homo sapiens NCAM1 protein protein. 77 5e-13
AK093069-1|BAC04042.1| 650|Homo sapiens protein ( Homo sapiens ... 77 5e-13
AY358125-1|AAQ88492.1| 937|Homo sapiens MAM-domain protein prot... 77 7e-13
AK125972-1|BAC86370.1| 365|Homo sapiens protein ( Homo sapiens ... 77 7e-13
AY369208-1|AAQ73312.1| 956|Homo sapiens MAM domain-containing g... 77 9e-13
AL513328-2|CAI17350.1| 867|Homo sapiens muscle, skeletal, recep... 77 9e-13
AL513328-1|CAI17349.1| 875|Homo sapiens muscle, skeletal, recep... 77 9e-13
AL157881-3|CAH69978.1| 867|Homo sapiens muscle, skeletal, recep... 77 9e-13
AL157881-2|CAH69977.1| 875|Homo sapiens muscle, skeletal, recep... 77 9e-13
BC114435-1|AAI14436.1| 1264|Homo sapiens Cdon homolog (mouse) pr... 76 2e-12
BC106716-1|AAI06717.1| 1496|Homo sapiens PTPRD protein protein. 76 2e-12
BC098583-1|AAH98583.1| 1287|Homo sapiens Cdon homolog (mouse) pr... 76 2e-12
BC031063-1|AAH31063.1| 602|Homo sapiens IGSF10 protein protein. 76 2e-12
AB177856-1|BAD66834.1| 1484|Homo sapiens LAR splice variant 1 pr... 76 2e-12
AB052622-1|BAB86306.1| 1250|Homo sapiens hDDM36 protein. 76 2e-12
AB037718-1|BAA92535.1| 2242|Homo sapiens KIAA1297 protein protein. 75 2e-12
AL117666-1|CAB56036.1| 483|Homo sapiens hypothetical protein pr... 75 3e-12
BC012102-1|AAH12102.1| 347|Homo sapiens PTPRF protein protein. 75 4e-12
AL583862-13|CAI14896.1| 347|Homo sapiens protein tyrosine phosp... 75 4e-12
AL583862-11|CAM12884.1| 262|Homo sapiens protein tyrosine phosp... 75 4e-12
DQ234351-1|ABB29980.1| 262|Homo sapiens protein tyrosine phosph... 74 5e-12
AF004841-1|AAC34901.2| 1264|Homo sapiens CDO protein. 74 5e-12
BC117370-1|AAI17371.1| 1065|Homo sapiens leucine-rich repeats an... 74 6e-12
BC117368-1|AAI17369.1| 1065|Homo sapiens leucine-rich repeats an... 74 6e-12
AL357055-1|CAH73254.1| 1065|Homo sapiens leucine-rich repeats an... 74 6e-12
AB208869-1|BAD92106.1| 1478|Homo sapiens protein tyrosine phosph... 74 6e-12
AB018349-1|BAA34526.2| 1073|Homo sapiens KIAA0806 protein protein. 74 6e-12
U33635-1|AAA87565.1| 1070|Homo sapiens colon carcinoma kinase-4 ... 73 1e-11
AY358328-1|AAQ88694.1| 1115|Homo sapiens BOC protein. 73 1e-11
AY027658-1|AAK14795.1| 1114|Homo sapiens brother of CDO protein. 73 1e-11
AK090455-1|BAC03436.1| 931|Homo sapiens FLJ00376 protein protein. 73 1e-11
AF058332-2|AAD22604.1| 926|Homo sapiens myocardium-specific tit... 73 1e-11
AF058332-1|AAD22603.1| 1019|Homo sapiens titin protein. 73 1e-11
BC048416-1|AAH48416.1| 353|Homo sapiens PTPRF protein protein. 73 1e-11
AL583862-12|CAI14897.1| 353|Homo sapiens protein tyrosine phosp... 73 1e-11
AL049946-1|CAB43220.1| 584|Homo sapiens hypothetical protein pr... 73 1e-11
AK027343-1|BAB55048.1| 507|Homo sapiens .117). protein. 73 1e-11
AB209478-1|BAD92715.1| 1552|Homo sapiens protein tyrosine phosph... 73 1e-11
BX538319-1|CAD98093.1| 1290|Homo sapiens hypothetical protein pr... 72 2e-11
BC033803-1|AAH33803.1| 338|Homo sapiens limbic system-associate... 72 2e-11
AF531871-1|AAN04865.1| 1014|Homo sapiens transmembrane receptor ... 72 2e-11
AJ314896-1|CAC85745.1| 163|Homo sapiens obscurin protein. 72 3e-11
U41901-1|AAC50569.1| 338|Homo sapiens LAMP protein. 71 3e-11
DQ464902-1|ABE97925.1| 675|Homo sapiens nexilin protein. 71 5e-11
BC114445-1|AAI14446.1| 567|Homo sapiens NEXN protein protein. 71 5e-11
BC114444-1|AAI14445.1| 567|Homo sapiens NEXN protein protein. 71 5e-11
AK057954-1|BAB71622.1| 505|Homo sapiens protein ( Homo sapiens ... 71 5e-11
BX537391-1|CAD97633.1| 143|Homo sapiens hypothetical protein pr... 71 6e-11
BC111395-1|AAI11396.1| 554|Homo sapiens NEXN protein protein. 71 6e-11
BC109099-1|AAI09100.1| 773|Homo sapiens MUSK protein protein. 71 6e-11
AF114264-1|AAD29607.1| 448|Homo sapiens unknown protein. 71 6e-11
AF006464-1|AAB63044.1| 869|Homo sapiens muscle specific tyrosin... 71 6e-11
BC036569-1|AAH36569.1| 627|Homo sapiens CNTN1 protein protein. 70 8e-11
AL591423-1|CAM13086.1| 1263|Homo sapiens chromosome 9 open readi... 70 8e-11
AL353895-2|CAM20931.1| 1263|Homo sapiens chromosome 9 open readi... 70 8e-11
AL158150-4|CAM14352.1| 1263|Homo sapiens chromosome 9 open readi... 70 8e-11
AC115538-1|AAY40987.1| 103|Homo sapiens unknown protein. 70 8e-11
X51602-1|CAA35946.1| 1338|Homo sapiens protein ( Human flt mRNA ... 70 1e-10
AL139005-1|CAI17096.1| 1338|Homo sapiens fms-related tyrosine ki... 70 1e-10
AL138712-1|CAI14846.1| 1338|Homo sapiens fms-related tyrosine ki... 70 1e-10
AF063657-1|AAC16449.2| 1338|Homo sapiens vascular endothelial gr... 70 1e-10
AF531869-1|AAN04863.1| 1030|Homo sapiens transmembrane receptor ... 69 1e-10
AL360004-4|CAI16954.2| 746|Homo sapiens novel protein similar t... 69 2e-10
AM231061-1|CAJ76912.1| 1960|Homo sapiens obscurin isoform B prot... 69 2e-10
AL670729-4|CAH71670.2| 2582|Homo sapiens obscurin, cytoskeletal ... 69 2e-10
AL353593-4|CAM27610.1| 2582|Homo sapiens obscurin, cytoskeletal ... 69 2e-10
AJ314908-1|CAC85755.1| 1020|Homo sapiens obscurin protein. 69 2e-10
AB046859-1|BAB13465.2| 2584|Homo sapiens KIAA1639 protein protein. 69 2e-10
DQ173642-2|ABC25979.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173641-2|ABC25974.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173640-2|ABC25969.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173639-2|ABC25964.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173638-2|ABC25959.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173637-2|ABC25954.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173636-2|ABC25949.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173635-2|ABC25944.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173634-2|ABC25939.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173633-2|ABC25934.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173632-2|ABC25929.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173631-2|ABC25924.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173630-2|ABC25919.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173629-2|ABC25914.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173628-2|ABC25909.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173627-2|ABC25904.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173626-2|ABC25899.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173625-2|ABC25894.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173624-2|ABC25889.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173623-2|ABC25884.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173622-2|ABC25879.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173621-2|ABC25874.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173620-2|ABC25869.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173619-2|ABC25864.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173618-2|ABC25859.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173617-2|ABC25854.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173616-2|ABC25849.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173615-2|ABC25844.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173614-2|ABC25839.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173613-2|ABC25834.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173612-2|ABC25829.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173611-2|ABC25824.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173610-2|ABC25819.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173609-2|ABC25814.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173608-2|ABC25809.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173607-2|ABC25804.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173606-2|ABC25799.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173605-2|ABC25794.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173604-2|ABC25789.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173603-2|ABC25784.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173602-2|ABC25779.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173601-2|ABC25774.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173600-2|ABC25769.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173599-2|ABC25764.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173598-2|ABC25759.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173597-2|ABC25755.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173596-2|ABC25750.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173595-2|ABC25745.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173594-2|ABC25740.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173593-2|ABC25735.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173592-2|ABC25730.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
DQ173589-1|ABB58724.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167726-1|AAO17629.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167725-1|AAO17628.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167724-1|AAO17627.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167723-1|AAO17626.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167722-1|AAO17625.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167721-1|AAO17624.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167720-1|AAO17623.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167719-1|AAO17622.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167718-1|AAO17621.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167717-1|AAO17620.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167716-1|AAO17619.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167715-1|AAO17618.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167714-1|AAO17617.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167713-1|AAO17616.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167712-1|AAO17615.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167711-1|AAO17614.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167710-1|AAO17613.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167709-1|AAO17612.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167708-1|AAO17611.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167707-1|AAO17610.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167706-1|AAO17609.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167705-1|AAO17608.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167704-1|AAO17607.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167703-1|AAO17606.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167702-1|AAO17605.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167701-1|AAO17604.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167700-1|AAO17603.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167699-1|AAO17602.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167698-1|AAO17601.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167697-1|AAO17600.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167696-1|AAO17599.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167695-1|AAO17598.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167694-1|AAO17597.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167693-1|AAO17596.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167692-1|AAO17595.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167691-1|AAO17594.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167690-1|AAO17593.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167689-1|AAO17592.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167688-1|AAO17591.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167687-1|AAO17590.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167686-1|AAO17589.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167685-1|AAO17588.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167684-1|AAO17587.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167683-1|AAO17586.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167682-1|AAO17585.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167681-1|AAO17584.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
AY167680-1|AAO17583.1| 534|Homo sapiens L1 cell adhesion molecu... 66 1e-09
BC107797-1|AAI07798.1| 179|Homo sapiens TTN protein protein. 66 1e-09
BC014205-1|AAH14205.2| 601|Homo sapiens NCAM1 protein protein. 65 2e-09
AY481573-1|AAS47698.1| 5202|Homo sapiens Usher syndrome 2A isofo... 65 3e-09
AL513305-1|CAH73621.1| 5202|Homo sapiens Usher syndrome 2A (auto... 65 3e-09
AL445650-4|CAH70621.1| 5202|Homo sapiens Usher syndrome 2A (auto... 65 3e-09
AL358858-2|CAH71588.1| 5202|Homo sapiens Usher syndrome 2A (auto... 65 3e-09
AL358452-1|CAI19189.1| 5202|Homo sapiens Usher syndrome 2A (auto... 65 3e-09
AL139259-1|CAI23041.1| 5202|Homo sapiens Usher syndrome 2A (auto... 65 3e-09
BX537361-1|CAD97607.1| 1191|Homo sapiens hypothetical protein pr... 64 4e-09
AY358132-1|AAQ88499.1| 352|Homo sapiens DMML2433 protein. 64 4e-09
BX538014-1|CAD97961.1| 355|Homo sapiens hypothetical protein pr... 64 5e-09
AL645724-1|CAI21858.1| 354|Homo sapiens neuronal growth regulat... 64 5e-09
AL627317-1|CAH72391.1| 354|Homo sapiens neuronal growth regulat... 64 5e-09
AL359821-1|CAH70913.1| 354|Homo sapiens neuronal growth regulat... 64 5e-09
AL356600-1|CAI23492.1| 354|Homo sapiens neuronal growth regulat... 64 5e-09
AL354949-1|CAI16869.1| 354|Homo sapiens neuronal growth regulat... 64 5e-09
BC030141-1|AAH30141.1| 1163|Homo sapiens immunoglobulin superfam... 64 7e-09
AL513485-5|CAI14605.1| 1179|Homo sapiens immunoglobulin superfam... 64 7e-09
AB037776-1|BAA92593.1| 1189|Homo sapiens KIAA1355 protein protein. 64 7e-09
AY211921-1|AAO65174.1| 294|Homo sapiens sarcoma antigen NY-SAR-... 63 1e-08
AK092307-1|BAC03858.1| 354|Homo sapiens protein ( Homo sapiens ... 63 1e-08
AL513485-4|CAI14606.1| 1163|Homo sapiens immunoglobulin superfam... 62 2e-08
BC036771-1|AAH36771.1| 226|Homo sapiens NEGR1 protein protein. 62 3e-08
AL627317-2|CAH72392.1| 226|Homo sapiens neuronal growth regulat... 62 3e-08
AL359821-2|CAH70914.1| 226|Homo sapiens neuronal growth regulat... 62 3e-08
AL356600-2|CAI23493.1| 226|Homo sapiens neuronal growth regulat... 62 3e-08
AL354949-2|CAI16870.1| 226|Homo sapiens neuronal growth regulat... 62 3e-08
AF040991-1|AAC39576.1| 285|Homo sapiens roundabout 2 protein. 61 5e-08
U57099-1|AAC50599.1| 113|Homo sapiens APEG-1 protein protein. 60 9e-08
CR542201-1|CAG46998.1| 113|Homo sapiens APEG1 protein. 60 9e-08
BC006346-1|AAH06346.1| 113|Homo sapiens SPEG protein protein. 60 9e-08
AK128689-1|BAC87572.1| 175|Homo sapiens protein ( Homo sapiens ... 60 9e-08
AK126500-1|BAC86568.1| 170|Homo sapiens protein ( Homo sapiens ... 60 9e-08
AF005070-1|AAB61615.1| 348|Homo sapiens neural cell adhesion mo... 60 9e-08
AC053503-3|AAY15052.1| 113|Homo sapiens unknown protein. 60 9e-08
BC045734-1|AAH45734.1| 442|Homo sapiens IGSF10 protein protein. 60 1e-07
AL050093-1|CAB43265.1| 145|Homo sapiens hypothetical protein pr... 60 1e-07
AY358128-1|AAQ88495.1| 717|Homo sapiens IGSF9 protein. 59 1e-07
AK222718-1|BAD96438.1| 820|Homo sapiens fibroblast growth facto... 59 1e-07
AK098838-1|BAC05429.1| 399|Homo sapiens protein ( Homo sapiens ... 59 1e-07
AB046848-1|BAB13454.1| 980|Homo sapiens KIAA1628 protein protein. 59 1e-07
AB209396-1|BAD92633.1| 675|Homo sapiens surface glycoprotein, I... 59 2e-07
X61656-1|CAA43837.1| 1354|Homo sapiens membrane protein protein. 58 3e-07
U42594-1|AAD00019.1| 782|Homo sapiens fibronectin protein. 58 3e-07
L04947-1|AAA59459.1| 1354|Homo sapiens receptor tyrosine kinase ... 58 3e-07
EF043567-1|ABK34282.1| 355|Homo sapiens neurotrimin variant 3 p... 58 3e-07
BX640638-1|CAE45786.1| 1034|Homo sapiens hypothetical protein pr... 58 3e-07
BC131822-1|AAI31823.1| 1356|Homo sapiens kinase insert domain re... 58 3e-07
>AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein.
Length = 30000
Score = 299 bits (733), Expect = 9e-80
Identities = 200/685 (29%), Positives = 321/685 (46%), Gaps = 41/685 (5%)
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL-TIKKV 1350
D + ++ G + L V + P P W + ++ + +D KS T +
Sbjct: 20625 DLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRD----RIGLDIKSTDFDTFLRC 20680
Query: 1351 ENT---DAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENT 1407
EN DAG Y L LEN+CG + + V +LD P PP + EI S + W+ P
Sbjct: 20681 ENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIID 20740
Query: 1408 GNSTIIYYVVEYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
G S II YVV+ ++ + W +V +KT + NL+ SY FR +A NE I D E
Sbjct: 20741 GGSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGE 20800
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITT--------EPNEDIELTCIFGGVPQPKVTWYRD 1518
T + +K ++ P V+ +++++ +P+ D + I G V +
Sbjct: 20801 TRD---AVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGG-SRIIGYVVDFLTEENKW 20856
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE 1578
+ +K+ Y + ++ A N++GE S + + + V+ +
Sbjct: 20857 QRVMKSLSLQYSAKDLTEGKEYT------FRVSAENENGEGTPSEITVVARDDVVAPDLD 20910
Query: 1579 -----DIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
D+ K + + I+G P P V W K + L D ++ + + + +
Sbjct: 20911 LKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVY 20970
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDD 1693
+ ++S + KYTI N AGT +++KV KP P GP+ E++ E++T++W PP DD
Sbjct: 20971 DCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDD 21030
Query: 1694 GGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEAL 1753
GG E+T Y +EK + NN+W+ A + T+ + +L+E EY FRV A+N G E L
Sbjct: 21031 GGSEITNYILEKRDSVNNKWVTCASAVQKT-TFRVTRLHEGMEYTFRVSAENKYGVGEGL 21089
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-K 1812
+SEPIV + DVP + ++SV +TW +K GGSPI Y +E K+
Sbjct: 21090 KSEPIVARHPFDVPD-APPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLL 21148
Query: 1813 WKXXXXX--XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR 1870
WK ++ L+ Y+FR+ A N G P + + + PP +P
Sbjct: 21149 WKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPE 21208
Query: 1871 NFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENI 1930
V T SVTL WTEP+ +GG +T YI+E + + KSW K V + ++
Sbjct: 21209 ---VINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDL 21265
Query: 1931 KEKDEIIFRISAENTVG-VSLPTES 1954
E + FRI A+NT G +S P+ES
Sbjct: 21266 VEGGKYEFRIRAKNTAGAISAPSES 21290
Score = 290 bits (711), Expect = 4e-77
Identities = 346/1472 (23%), Positives = 590/1472 (40%), Gaps = 117/1472 (7%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F+K V E I L C V+ P ++ W EEI+ + E +L
Sbjct: 13392 FTKNLANIEVSETDTIKLVCE-VSKPGAEVIWYKGDEEIIETGRYEILTEGRKR----IL 13446
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
I N G Y + + K+K E + +P +++ + +GE
Sbjct: 13447 VIQNAHLEDAGNYNCRLPSSRTDG------KVKVHELAAEFISKP-QNLEILEGEKAEFV 13499
Query: 756 AQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ P + W +++K +++ +DG + ++K ++D G Y + G
Sbjct: 13500 CSISKESFP-VQWKRDDKTLESGDKYDVIADGKKR-VLVVKDATLQDMGTYVVMV----G 13553
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
A +A +TV E + ++ VKE+ + V + W+RN E
Sbjct: 13554 AARAAAHLTVIEKLR-------IVVPLKDTRVKEQQEVVFNCEVNTEGAKA-KWFRNEEA 13605
Query: 873 ISPSET--ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-SHGARVTIDVEKVT 929
I S I Q + + ++D D +Y +N G++ A + ++ E +
Sbjct: 13606 IFDSSKYIILQKDLVYTLRIRDAHLD---DQANYNVSLTNHRGENVKSAANLIVEEEDLR 13662
Query: 930 FVKHLQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
V+ L K ET E K+V C+ + V+ KW N +E+ D+R + +
Sbjct: 13663 IVEPL-KDIETMEKKSVTFWCKVNRLNVTLKWTKNGEEVP-FDNRVSYRVDKYKHMLTIK 13720
Query: 989 XXXX-DVG-VIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD 1046
D G I +D+ + +L++ E EF+ L+D V E D A+ +++ E A+
Sbjct: 13721 DCGFPDEGEYIVTAGQDKSVAELLII-EAPTEFVEHLEDQTVTEFDDAVFSCQLSREKAN 13779
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELP 1106
V W R+G IK K KY FEK G I +L I++ + DE EY+C + D A + V E+P
Sbjct: 13780 VKWYRNGREIKEGK-KYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIP 13838
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
EII Q+ G F EL K V+W ++ + + Q+ +GK +L+I
Sbjct: 13839 VEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQIC 13898
Query: 1167 DCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
D D GEY + + A L + ++ + LV + LT+ +P +
Sbjct: 13899 DIKPRDQGEYRFIAKDKEARAKLELAAAP---KIKTADQDLV-VDVGKPLTMVVPYDAYP 13954
Query: 1226 --DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKV 1281
+ W+K+ E T+ + ++ + I + + D+ Y VL + K+ + +
Sbjct: 13955 KAEAEWFKEN---EPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINL 14011
Query: 1282 EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPND--EWIVNSKIIKKCKHTKPSID 1339
+V++ P + + E +V+L + + ++V + IK+ +
Sbjct: 14012 KVIDVPGPVRNLEVTETFD--GEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDR 14069
Query: 1340 SKSASLTIKKVENTDAG-IYKLRLENNCGHAD-VEMNVTI-----LDKPSPPGKPNILEI 1392
++S T+ ++ ++++ N G + VE + + D P PP I ++
Sbjct: 14070 AESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDV 14129
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYR 1450
+ +++ W+ PE G + I YV+E ++ + W + + S + ++ Y
Sbjct: 14130 NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYS 14189
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE-DIELTCIFGGVP 1509
FR A N + + S T + KV + SP V + T + E GG P
Sbjct: 14190 FRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSP 14249
Query: 1510 ----------QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
+ K W R KL + TY+ Y+ A N G
Sbjct: 14250 ILGYIIERCEEGKDNWIRCNMKL-VPELTYK------VTGLEKGNKYLYRVSAENKAGVS 14302
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE------GIPPPEVIWYKNGNKL 1613
+ S ++G + K G E +V I G P P W L
Sbjct: 14303 DPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVL 14362
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
E + T + + I +RS YT++ N T S E+ + V +PS P+ +
Sbjct: 14363 ETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPK-EL 14421
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNE 1733
+I+++SV + W+PP DDGG LT Y +EK E W KV D D+E + + L +
Sbjct: 14422 KFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLE-FTVPDLVQ 14480
Query: 1734 NCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE 1792
EY+F+V A+N G E A EP+ + T VP N S+++TW P +
Sbjct: 14481 GKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTAN-SIFLTWDPPK 14539
Query: 1793 KNGGSPIIDYKVEIKQEGK-KWKX-XXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+GGS I Y VE G KW + L Y +R+ A N G S P
Sbjct: 14540 NDGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKP 14599
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK 1910
++I T P + + + K P + G P E K
Sbjct: 14600 SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKP------EPKI---- 14649
Query: 1911 SWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATV----- 1965
+WTK + IEN+ +K + S + G + E+ +V A V
Sbjct: 14650 TWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVL 14708
Query: 1966 --PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
P PP A +I V + + +W P DGG+ + Y + R +W ++ V
Sbjct: 14709 DKPGPPAA-FDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSST-VKD 14766
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
F L N Y+ R+ A N G+ EP+++
Sbjct: 14767 TNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 14798
Score = 283 bits (695), Expect = 4e-75
Identities = 321/1444 (22%), Positives = 574/1444 (39%), Gaps = 102/1444 (7%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G +C L + + + W KG+++ P + + E +H L + +VK
Sbjct: 13134 VTAGETATFDCEL-SYEDIPVEWYLKGKKLEPSDKVVPRSEGKVH----TLTLRDVKLED 13188
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP-QVIEPLKSMIVRQGESVILSAQVVGNPR 763
G + A + + A+L + KEPP + +PL+ V +G + +L +V
Sbjct: 13189 AGEVQLTAKDFKTHANLFV--------KEPPVEFTKPLEDQTVEEGATAVLECEV-SREN 13239
Query: 764 PTITWCKNNKPV---KALPTKSDGDTHSITI--LKPKKVKDEGVYTLKAENSEGIAETSA 818
+ W KN + K +DG + I P+ +K YT A++ + TS
Sbjct: 13240 AKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIK---TYTCDAKDFK----TSC 13292
Query: 819 VITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET 878
+ V P E F+ ++ V+EK + ++R + W+++ I +
Sbjct: 13293 NLNVVPPHVE------FLRPLTDLQVREKEMARFECELSRENA-KVKWFKDGAEIKKGKK 13345
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
G + +++ N D +Y C + ++S +T+ E+ F K+L +
Sbjct: 13346 YDIISKGA-VRILVINKCLLDDEAEYSCEVRTA--RTS--GMLTVLEEEAVFTKNLA-NI 13399
Query: 939 ETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
E E T+ L C+ S WY +EI EI+ EGR D G
Sbjct: 13400 EVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNY 13459
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
C + T + V E EFI K Q+ E+ E + A I+ E+ V W+RD + ++
Sbjct: 13460 NCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLE 13519
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
+KYD G R L +++ ++ D G Y ++ A +TV+E I+ L++ +
Sbjct: 13520 -SGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTR 13577
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + + F E+ A +WF++ I S+ + L+I D LDD Y+
Sbjct: 13578 VKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYN 13637
Query: 1178 CEVGNS-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
+ N K A L VEE + L + + + + ++ + + W K
Sbjct: 13638 VSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWC-KVNRLNVTLKWTKN 13696
Query: 1233 KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
+ + + D K L I+ C D+ EY KS +L + +E P + V+
Sbjct: 13697 GEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLI--IEAPTEFVE 13754
Query: 1293 YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
+ + + D + N +W N + IK+ K K D L IK
Sbjct: 13755 HLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRL 13813
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTI 1412
D Y +E+ A + + ++ PP +ILE + + + ++
Sbjct: 13814 DDECEYACGVEDRKSRARLFVEEIPVEIIRPP--QDILEAPGADVVFLAELNKDKVEVQW 13871
Query: 1413 IYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
+ + + D + +S I + Q + YRF I+ E +
Sbjct: 13872 LRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRF---------IAKDKEARAKLE 13922
Query: 1473 VIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA-TYEN 1531
+ KI++ +++ + + + + + P+ + W+++ + L T T
Sbjct: 13923 LAAAPKIKTAD-----QDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAE 13977
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH--KVGDE 1589
+ YK + N HG+ E + + P + N ++ + +V
Sbjct: 13978 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPG-PVRNLEVTETFDGEVSLA 14036
Query: 1590 WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSK-YTIEA 1647
W G ++I Y + K + + T S + L++ + + A
Sbjct: 14037 WEEPLTDGG---SKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSA 14093
Query: 1648 SNTAGTSS-VEVTLKV-----YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
N GT VE V YD P P V + +++R V++ W+PP DGG E+T Y
Sbjct: 14094 RNRVGTGEPVETDNPVEARSKYDVPGPPLN-VTITDVNRFGVSLTWEPPEYDGGAEITNY 14152
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV-I 1760
IE + + RW V + + + + E EY FRV AQN +G + + P V +
Sbjct: 14153 VIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKV 14212
Query: 1761 KTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KW--KXXX 1817
++ PS + SV + W P K+GGSPI+ Y +E +EGK W
Sbjct: 14213 ADPIERPSPPVNLTSSDQTQS-SVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMK 14271
Query: 1818 XXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN-FVVSE 1876
++ L Y +R+ A N+ G S P +T P+ + F
Sbjct: 14272 LVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGL 14331
Query: 1877 STSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEI 1936
+ P + P + K ++ K+ T+ + E I + D+
Sbjct: 14332 EVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTL-SAYAELVISPSERSDKG 14390
Query: 1937 IFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM--VGSNIVMTSWGTPEWDG 1994
I+ + EN V +++ E V + P+AP E++ + + V +W P+ DG
Sbjct: 14391 IYTLKLENRV--------KTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDG 14442
Query: 1995 GAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
G+PL GY + R+V++ W +V V L+F + DL + Y+ ++ ARN+ G EP
Sbjct: 14443 GSPLTGYVVEKREVSRKTWTKVMDF-VTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAY 14501
Query: 2055 SDEP 2058
DEP
Sbjct: 14502 VDEP 14505
Score = 276 bits (676), Expect = 7e-73
Identities = 202/711 (28%), Positives = 312/711 (43%), Gaps = 35/711 (4%)
Query: 1287 PPKIV---DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK-- 1341
PP+++ + RE IK G + L + P P W K + TK ID
Sbjct: 18142 PPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTW----KKEDRDAPTKARIDVTPV 18197
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
+ L I+ + D GIY L +EN G V + V +LDKP PP + EI S + W
Sbjct: 18198 GSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTW 18257
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSI-QNLKTNSSYRFRAYAVNEVD 1460
EP + G S I YVVE +++ + +W + +K ++ ++L + Y FR A N+
Sbjct: 18258 KEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYG 18317
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF----GGVPQPK--VT 1514
ET + K + + P K L ++ + E + L GG P V
Sbjct: 18318 RGPFVETPKPIKALDP--LHPPGPPKDLHHVDVDKTE-VSLVWNKPDRDGGSPITGYLVE 18374
Query: 1515 WYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
+ +G + T N K G +T+ + Q+K V
Sbjct: 18375 YQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVP 18434
Query: 1574 TISNEDIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV 1629
D+K K G A+I G+P P W +G++++ D+ Y + T +SV
Sbjct: 18435 PSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV 18494
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKP 1689
+ IK R + +Y I SN AG+ +V V L V D P P GP+ + +++ E +TI W+P
Sbjct: 18495 LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQP 18554
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGF 1749
P DDGG + Y +EK + + W V+ + I L + CEY+FRV A+N +G
Sbjct: 18555 PKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLK-IPHLQKGCEYVFRVRAENKIGV 18613
Query: 1750 SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQE 1809
L+S P V K PS +N + ++W + +GGSPI Y +E ++
Sbjct: 18614 GPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT-VSWTLPKSDGGSPITGYYMERREV 18672
Query: 1810 GKKWKXXXXX--XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS 1867
KW R+ L TY+FR++A N G S P S D I + + PP
Sbjct: 18673 TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPG 18732
Query: 1868 QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC- 1926
P N + + + + L WT+P S+GGSPI Y++E + W +I + C
Sbjct: 18733 PPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINK--DELIRQCA 18790
Query: 1927 --IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ + E +E FRI A N VG P E + K + PP L++
Sbjct: 18791 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAK--DILHPPEVELDV 18839
Score = 267 bits (654), Expect = 3e-70
Identities = 275/1199 (22%), Positives = 476/1199 (39%), Gaps = 92/1199 (7%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
+E+ + P F KL+ H G V FEC++ G Q++W++ ++K + Q +
Sbjct: 8037 KERKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSF-VH 8095
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
NVATL I + G + C A N G ASS+ +LI LS+H
Sbjct: 8096 NVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLI----LSEH---------------- 8135
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
+PP F KP + + G +C + I W EI P N +
Sbjct: 8136 -------EVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMT 8188
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLK- 742
+ + + L + V K G YT A N G+ S L G +EPP+ I+ L+
Sbjct: 8189 LVEN----TATLTVLKVGKGDAGQYTCYASNIAGKDSCSAHL----GVQEPPRFIKKLEP 8240
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK--KVKDE 800
S IV+Q E ++ G+P + W K+ ++ S+ +L+ V+D
Sbjct: 8241 SRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDS 8300
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
G YT +A N+ G A +S + V+ EPP+F + I + + L + P
Sbjct: 8301 GDYTCEAHNAAGSASSSTSLKVK-------EPPIFRKKPHPIETLKGADVHLECELQGTP 8353
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
++WY++ + + + + I NVD+ D G+Y+C A+N G +
Sbjct: 8354 PFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDA-ADIGEYQCKATNDVGSDTCVGS 8412
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILE--CQTSHTVSTKWYHNKKEI-SGMDHREIIQ 977
+ + FVK L T GK V L+ + + +S W+ +K EI D+ I
Sbjct: 8413 IALKAPP-RFVKKL-SDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISY 8470
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQDFEVKEKDV 1033
+ G C +K+ QE L V E + K + +V D
Sbjct: 8471 SENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEP-ATIVEKPESIKVTTGDT 8529
Query: 1034 AILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
LE + + W +DG+ + NKY + L I N + D G YS ++
Sbjct: 8530 CTLECTVAGTPELSTKWFKDGKEL-TSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQ 8588
Query: 1093 D----ESCTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSE 1145
+ +SCTA + V + +PP +L+ G+ E ++ + V WF +G+E
Sbjct: 8589 NPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNE 8648
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
I Q T+ L + + D+G+Y+C G+ +C+A LTV EP
Sbjct: 8649 ISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKP 8708
Query: 1202 LPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTED 1261
P +L N + ++ V+W+K S + ++ + + L +
Sbjct: 8709 DPMDVLTGTNV-TFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTS 8767
Query: 1262 DQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE 1320
EYTC++ + + ++ P K V +Y I++G + L + P +
Sbjct: 8768 QSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVT 8827
Query: 1321 WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
W N + + + KSA L I DAG Y +EN G + IL+
Sbjct: 8828 WKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEP 8887
Query: 1381 P--SPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQ 1437
P +P + + S+ C + T + +Y + + TT + + +N T
Sbjct: 8888 PYFVKQLEPVKVSVGDSASLQC--QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATL 8945
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE 1497
+ N S + A N V + S +T + ++E K+ P+ + L+++
Sbjct: 8946 V-FNQVDINDSGEYICKAENSV--GEVSAST--FLTVQEQKL-PPSFSRQLRDVQETVGL 8999
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTA----KATYENRXXXXXXXXXXXXXXXYKCIAF 1553
+ C G V+WY+DGK LK + + +N Y C A
Sbjct: 9000 PVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTAT 9059
Query: 1554 NDHGEVETSCVVGI---QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
N G +S + + + P I + VG+ + G P +V W K+
Sbjct: 9060 NPIGSASSSARLILTEGKNPPFFDIRLAPVDA--VVGESADFECHVTGTQPIKVSWAKDS 9117
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
++ + +Y I+ E ++ + + ++ + S +YT A N G S L + ++ P
Sbjct: 9118 REIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPP 9176
Score = 262 bits (643), Expect = 7e-69
Identities = 222/868 (25%), Positives = 365/868 (42%), Gaps = 58/868 (6%)
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP 1287
TW V+E ++ + + L+I D+ YT L + T +++V
Sbjct: 14354 TWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 14413
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-------WIVNSKIIKKCKHTKPSIDS 1340
E ++ D+T + + P+D+ ++V + + + TK
Sbjct: 14414 RPSAPKELKF-----GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFV 14468
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCG-----HADVEMNV-TILDKPSPPGKPNILEIDS 1394
T+ + ++K+ N CG + D +N+ T P PP + +
Sbjct: 14469 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTA 14528
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRA 1453
+SI + WD P+N G S I Y+VE + +W++ + + +T+ + L+ Y +R
Sbjct: 14529 NSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRV 14588
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVE-KPLKNITTEPNEDIELTCIFGGVPQPK 1512
A+N S S TE + + + ++ K L +T + IEL G P+PK
Sbjct: 14589 KALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPK 14648
Query: 1513 VTWYRDGKKLKTAK-ATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+TW + LK K T EN + Y A N G V +
Sbjct: 14649 ITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVL 14708
Query: 1569 QKP-------VITISNEDI----KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK 1617
KP + ++NE G + V+E +W+K + +++
Sbjct: 14709 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKD-- 14766
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG----TSSVEVTLKVYDKPSKPEGPV 1673
T + T +I KE + + A N G + +T K P P +
Sbjct: 14767 ----TNFKATKLIPNKEY------IFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRL 14816
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNE 1733
+I++++VT+ W P DDGG +T Y +E+ +PD ++W++ + TY ++ L
Sbjct: 14817 EPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTN 14876
Query: 1734 NCEYMFRVIAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE 1792
+Y FRV+A+N G + +S EPI+IK +D P + SV + W E
Sbjct: 14877 KKKYRFRVLAENLAGPGKPSKSTEPILIKDPID-PPWPPGKPTVKDVGKTSVRLNWTKPE 14935
Query: 1793 KNGGSPIIDYKVEIKQEG-KKW-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+GG+ I Y +E+ + G +W + + L Y FR+ A N+ G S P
Sbjct: 14936 HDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEP 14995
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK 1910
D + + L PPS PR V T + LKWT PE +GGSPITNYI+E + V+ K
Sbjct: 14996 SEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRK 15055
Query: 1911 SWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHA-TVPSPP 1969
W + T + + + E +FR++AEN +G S TE + L K T P PP
Sbjct: 15056 GWQTVDTTVKDT-KCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPP 15114
Query: 1970 TAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIR 2029
A L + V V W P+ DGG P+ Y I ++ T W++ GK F +
Sbjct: 15115 YA-LAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 15173
Query: 2030 DLSENHTYMIRIYARNEIGLSEPLESDE 2057
D+ E ++ A NE G+ P E E
Sbjct: 15174 DVIEGTEVQFQVRAENEAGVGHPSEPTE 15201
Score = 261 bits (640), Expect = 2e-68
Identities = 260/1070 (24%), Positives = 452/1070 (42%), Gaps = 66/1070 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PP+F+++ K G + L CRL + W G + DEN+ + ++
Sbjct: 7100 LPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNV--- 7156
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+ LKI G Y+ A N G AS L + +K P I+P+ S+ V GES
Sbjct: 7157 -ATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPV-SIDVIAGES 7214
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
V G ITW K+NK ++ G+T + ILK K D G YT +A
Sbjct: 7215 ADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGK-GDSGQYTCQAT 7273
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWY 867
N G SA ++V+ EPP F+ + + V ++G +I+L +++ +P ++W+
Sbjct: 7274 NDVGKDMCSAQLSVK-------EPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWF 7326
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
RN+ + S +F ++ L+ N S DSGDY C A N G +S +T+
Sbjct: 7327 RNDSELHESWKYNMSFI-NSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPP 7385
Query: 928 VTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
V K +G VIL+C+ S T W ++K++ +I +
Sbjct: 7386 VFTQK--PSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLH 7443
Query: 986 XXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS 1042
DVG C ++ +T + V + P F++KL D D L +
Sbjct: 7444 ILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEG 7503
Query: 1043 -ETADVVWERD-GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----C 1096
+ VVW +D GE+I+ +N +I L + + + G+Y C +++++ C
Sbjct: 7504 FQPISVVWLKDRGEVIRESENT-RISFIDNIATLQLGSPEASNSGKYICQIKNDAGMREC 7562
Query: 1097 TAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLT 1155
+A +TV+E P II + + V GN E +T L +WFKDG E+ + +T
Sbjct: 7563 SAVLTVLE-PARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHIT 7621
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRL--PEFILVPANTD 1213
K LKI ++ D G YS EV NS + TV S++ + R+ P FI + +
Sbjct: 7622 FINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTV---SVHVSDRIVPPSFIRKLKDVN 7678
Query: 1214 AYLTVEIPDE-------TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
A L + E + V W++ + I K TL + D Y
Sbjct: 7679 AILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIY 7738
Query: 1267 TCVLLDAKSTTKLK-VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS 1325
TCV + + + V V+ PP + G +T + P +W S
Sbjct: 7739 TCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGS 7798
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
+ + + S++ L + +V+ ++G Y + N+ G A ++ + + +
Sbjct: 7799 RELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVK 7858
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQTSIQNLK 1444
+ +++ S + E TG I + ++ + I +E S+ +T+ T ++ L+
Sbjct: 7859 RLADFSVETGSPIVL--EATYTGTPPISVSWIKDEYLISQSERCSI-TMTEKSTILEILE 7915
Query: 1445 -TNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTC 1503
T Y + + D E + ++ P +PL+++ E L C
Sbjct: 7916 STIEDYAQYSCLIENEAGQDICEAL-------VSVLEPPYFIEPLEHVEAVIGEPATLQC 7968
Query: 1504 IFGGVPQPKVTWYRDGKKLKTA---KATYENR-XXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
G P+ +++WY++ KL++A K ++N Y C A N G V
Sbjct: 7969 KVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAV 8028
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHK-VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+S V+ I+++ + +K H+ +G I G P +V WYK+G L++D
Sbjct: 8029 ASSAVLVIKERKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDAN 8088
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT--SSVEVTLKVYDKP 1666
+ + ++I + +SH +Y ASN GT SS ++ L ++ P
Sbjct: 8089 LQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVP 8138
Score = 261 bits (640), Expect = 2e-68
Identities = 196/695 (28%), Positives = 303/695 (43%), Gaps = 41/695 (5%)
Query: 1282 EVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SI 1338
E +E P +D E + I+ G + L V + P P +W K+ + + +
Sbjct: 23862 EKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW---GKVDGEIRDAAIIDV 23918
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
S SL + V D+G Y L LEN+ G + V +LD PSPP + EI S++
Sbjct: 23919 TSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVS 23978
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVN 1457
I W+ P G S I Y+VE +E + +V N K I L+ SY FR A N
Sbjct: 23979 ITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAEN 24038
Query: 1458 EVDISDASETTEYYKVIKETKIQSP-TVEKPLKNIT----TEPNEDIELTCIFGGVP-QP 1511
E I ++T + KV + + TV+ +N T+P D I V Q
Sbjct: 24039 EYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQA 24098
Query: 1512 KVTW-YRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET-SCVVGIQQ 1569
K + + + ++K+ +A N ++ +A N+ G + S V I
Sbjct: 24099 KHSEKWSECARVKSLQAVITN--------LTQGEEYLFRVVAVNEKGRSDPRSLAVPIVA 24150
Query: 1570 KPVITISNEDIKQKH-----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
K ++ D+K +VG + + I G P P + W K+G L+ N+T
Sbjct: 24151 KDLVI--EPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDS 24208
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + IKE + +Y I +N G + + + DKP P+GPV ++S ES+T
Sbjct: 24209 LDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESIT 24268
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
+ W PPL GG ++T Y ++K + W + A V R T + KL EY FR+ A
Sbjct: 24269 LSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVAR--TTLKVTKLKTGTEYQFRIFA 24326
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
+N G S ALES+PIV + P I +S+ I W NGGSP+I Y
Sbjct: 24327 ENRYGQSFALESDPIVAQYPYKEPG-PPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYH 24385
Query: 1804 VEIKQEGK-KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
+E K+ W + Q L Y+FR+YA N +G + +
Sbjct: 24386 LERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVAR 24445
Query: 1861 KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG 1920
PP P +V + +TL+WT+P +GGS IT YI+E + + W K
Sbjct: 24446 DPCDPPGTPEPIMVKRN---EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNV 24502
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVG-VSLPTES 1954
+ + + E FR+ A+N G +S P++S
Sbjct: 24503 IETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDS 24537
Score = 256 bits (628), Expect = 5e-67
Identities = 263/1191 (22%), Positives = 485/1191 (40%), Gaps = 95/1191 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
++ + P F+ KL+ + G++V EC+V G + WF+ I Q + + N
Sbjct: 7663 DRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSE-N 7721
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
V TL + + P D G +TCVA N AG + L V+ P S + +V
Sbjct: 7722 VCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSV----------- 7770
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
++L G+ TF+ V G+ P + W E+VP E+ ++++
Sbjct: 7771 --EVLPGMSLTFTS------VIRGT-----------PPFKVKWFKGSRELVPGESCNISL 7811
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + + L++ V+ + G Y+ + N G AS L + KEP ++ L
Sbjct: 7812 ED----FVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFV----KEPATFVKRLADF 7863
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK--PKKVKDEGV 802
V G ++L A G P +++W K+ + S T TIL+ ++D
Sbjct: 7864 SVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQ 7923
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
Y+ EN G A+++V EPP FI + + L +V P
Sbjct: 7924 YSCLIENEAGQDICEALVSV-------LEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEI 7976
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
I+WY+ + + + F LVI VD D G+Y C A NS G + A +
Sbjct: 7977 RISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHS-DVGEYSCKADNSVGAVASSAVLV 8035
Query: 923 IDVEKVT--FVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQE 978
I K+ F + L+ +ET G V EC+ S + WY + + + +
Sbjct: 8036 IKERKLPPFFARKLKDVHET-LGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFV 8094
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKD----QETSTMLVVKE-TIPEF--IRKLQ-DFEVKE 1030
+G C + +S L++ E +P F ++ + D + E
Sbjct: 8095 HNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGE 8154
Query: 1031 KDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC- 1089
V + + W +D I+P N Y + L + D G+Y+C
Sbjct: 8155 SGTFKCHV-TGTAPIKITWAKDNREIRPGGN-YKMTLVENTATLTVLKVGKGDAGQYTCY 8212
Query: 1090 ---ILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKAT-FEIELTKGDAL-VRWFKDGS 1144
I +SC+A + V E PP I +L+ ++ K ++ T +E ++ + V W+KD +
Sbjct: 8213 ASNIAGKDSCSAHLGVQE-PPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDET 8271
Query: 1145 EIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTL 1200
EIQ S+ +++ L++++ ++D+G+Y+CE G++ + L V+EP I
Sbjct: 8272 EIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPI--FR 8329
Query: 1201 RLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
+ P I D +L E+ V+WYK K + +K+ ++S+ ++ I
Sbjct: 8330 KKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVD 8389
Query: 1260 EDDQCEYTC-VLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
D EY C D S T + ++ PP+ V + G +V L + +
Sbjct: 8390 AADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPIS 8449
Query: 1319 DEWIVN-SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
W + +I+++ + S A+L +VE +AG Y +++N+ G + +++
Sbjct: 8450 VVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV 8509
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKT 1436
L+ + KP +++ + + C E G + + + +E+ + + K
Sbjct: 8510 LEPATIVEKPESIKVTTG--DTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKV 8567
Query: 1437 Q-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N+ + S + N V + + + + P+ + LK
Sbjct: 8568 SGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQV-----SDRTVPPSFTRKLKETNGLS 8622
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCI 1551
+ + C G P V+W+ +G ++ + + +N Y CI
Sbjct: 8623 GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCI 8682
Query: 1552 AFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGN 1611
A N G E S + +++ P + D G T++++G PP V W+K +
Sbjct: 8683 ATNMAGSDECSAPLTVREPPSF-VQKPD-PMDVLTGTNVTFTSIVKGTPPFSVSWFKGSS 8740
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+L N++ ++ + + + ++ S S +YT SN AG +S L +
Sbjct: 8741 ELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYI 8791
Score = 252 bits (616), Expect = 1e-65
Identities = 252/1068 (23%), Positives = 432/1068 (40%), Gaps = 60/1068 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P +K V G LEC++ PE + W G+ + + + + +
Sbjct: 6630 PAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKI---- 6685
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
S L+I +V++ GTYT N G++S V+ + + PP LK+ G S
Sbjct: 6686 SSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDV-SDRAVPPSFTRRLKNTGGVLGASC 6744
Query: 753 ILSAQVVGNPRPTITWC-KNNKPVKALPTKSDGDTHSITI-LKPKKVKDEGVYTLKAENS 810
IL +V G+ ++ W + K V ++ + T+ L D G YT A N
Sbjct: 6745 ILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANV 6804
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G E AV+TV+EP P F+ + + V + + + P + W+R
Sbjct: 6805 AGSDECRAVLTVQEP-------PSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGA 6857
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
+ + F+ EL + N+D SG+Y CV SN+AG++S R+ + E F
Sbjct: 6858 RELVKGDRCNIYFEDTVAELELFNIDIS-QSGEYTCVVSNNAGQASCTTRLFVK-EPAAF 6915
Query: 931 VKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+K L + E GK++ILE + T +S W + I+ + I+ +
Sbjct: 6916 LKRLS-DHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILN 6974
Query: 989 XXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI-NSET 1044
D G C ++++ + LV P F+ +L+ E D L+ ++ +
Sbjct: 6975 STKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPE 7034
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV- 1103
V W + ++P +Y ++ L +++D GEY+C + TA V
Sbjct: 7035 ITVSWYKGDTKLRPTP-EYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVF 7093
Query: 1104 -----ELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTID 1157
+LPP +L++ + G T L + V W++DG ++ ++Q +
Sbjct: 7094 RIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFV 7153
Query: 1158 GKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSIN--FTLRLPEFILVPAN 1211
LKI DL +G+YSC +G + +A LT EP + F ++ P I V A
Sbjct: 7154 DNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIK-PVSIDVIAG 7212
Query: 1212 TDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
A + + + +TW K I +T+ L I K + D +YTC
Sbjct: 7213 ESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQA 7272
Query: 1271 LD--AKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVN-SK 1326
+ K ++ V E PPK V ++ K+G + L P+ W N S+
Sbjct: 7273 TNDVGKDMCSAQLSVKE-PPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSE 7331
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
+ + K+ I+S A LTI + D+G Y N G A +T+ P K
Sbjct: 7332 LHESWKYNMSFINSV-ALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQK 7390
Query: 1387 PNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTN 1446
P+ + S I E T +++ Q ++ ++ T I NL+ +
Sbjct: 7391 PSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEAS 7450
Query: 1447 SSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG 1506
+ A NEV SD + +K + P K L + +T + +EL I
Sbjct: 7451 DVGEYHCKATNEVG-SDTCSCSVKFK-------EPPRFVKKLSDTSTLIGDAVELRAIVE 7502
Query: 1507 GVPQPKVTWYRD-GKKLKTAKAT----YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G V W +D G+ ++ ++ T +N Y C ND G E
Sbjct: 7503 GFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMREC 7562
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
S V+ + + I E + G+ + + V+ G P W+K+G +L D +++I
Sbjct: 7563 SAVLTVLEPARIIEKPEPMTV--TTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHI 7620
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
T K + ++I + S Y+ E N+ G S+ V++ V D+ P
Sbjct: 7621 TFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPP 7668
Score = 251 bits (615), Expect = 2e-65
Identities = 271/1159 (23%), Positives = 474/1159 (40%), Gaps = 79/1159 (6%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ E PPTF +PK+ G C + P + W G + P N ++ +
Sbjct: 4472 VTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWKISDAEN 4531
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
H +L+++N+ G Y+ A N+ G A + I + + +EP++S I
Sbjct: 4532 KH----ILELSNLTIQDRGVYSCKASNKFG-ADICQAELIIIDKPHFIKELEPVQSAI-- 4584
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSITILKP-KKVKDEGVYTL 805
+ V L QV + + T+TW K+ + + K + T+ P K+KD G Y
Sbjct: 4585 -NKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVC 4643
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSI 864
A N G + SA +TV EPP F+ + + G + +L ++ +PV +
Sbjct: 4644 TASNEAGSSSCSATVTVR-------EPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQV 4696
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
TW++NN+ +S S T+ F L IT+V E DSG Y C A N G S + I
Sbjct: 4697 TWFKNNKELSESNTVRMYFVNSEAILDITDVKVE-DSGSYSCEAVNDVGSDSCSTEIVIK 4755
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXX 982
E +F+K L+ + + G +L+C+ S T W+ +KK+I + +
Sbjct: 4756 -EPPSFIKTLEPA-DIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLV 4813
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTML--VVKETIPEFIRKLQDFEVKEKDVAILEV 1038
DVG +C+V ++ + M ++KE P F++K+ D L+
Sbjct: 4814 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEP-PTFVKKVDDLIALGGQTVTLQA 4872
Query: 1039 EI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES-- 1095
+ SE V W + E+I+ + K + L I + + G+Y+C+ +E+
Sbjct: 4873 AVRGSEPISVTWMKGQEVIR-EDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS 4931
Query: 1096 -CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQ 1153
+ +V+ P +II R + +V G+ AT E + L +W+KDG + S +
Sbjct: 4932 QTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYR 4991
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEY----SCEVGNSKCTAILTVEEPSIN--FTLRLPEFIL 1207
++ +LK Y +L D+G+Y S EVG+S C TV + I FT L
Sbjct: 4992 ISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDS 5051
Query: 1208 VPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
V N L +I + V+W+K I ++++ + +L I + +D +
Sbjct: 5052 V-VNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNF 5110
Query: 1267 TCVLLDA-KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS 1325
TC ++ S +V+ PP V + GS V L +Q W +
Sbjct: 5111 TCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGN 5170
Query: 1326 KII---KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
K + C TK +++S SL + V+ +D+G Y ++ N G + N+ + + +
Sbjct: 5171 KELVSGGSCYITKEALES---SLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPAT 5227
Query: 1383 PPGK---PNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQT 1438
K +L+ ++ C + TG I I + +EI + + + T
Sbjct: 5228 FVEKLEPSQLLKKGDATQLAC----KVTGTPPIKITWFANDREIKESSKHRMSFVESTAV 5283
Query: 1439 -SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE 1497
+ ++ S + A NE S ++KE SP K K I
Sbjct: 5284 LRLTDVGIEDSGEYMCEAQNEAGSDHCSSIV----IVKE----SPYFTKEFKPIEVLKEY 5335
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATY--ENRXXXXXXXXXXXXXXXYKCIAF 1553
D+ L G P ++TW++D L++ + T+ ++ Y+C
Sbjct: 5336 DVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVT 5395
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKL 1613
N+ G S V +++ P E G A ++G P V W K+ +++
Sbjct: 5396 NEVGSSICSARVTLREPPSFIKKIESTSSLR--GGTAAFQATLKGSLPITVTWLKDSDEI 5453
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
D +T + + + + ++ H KY +A N AG L V + + E V
Sbjct: 5454 TEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAV 5513
Query: 1674 IMREISRESVTIEWKPPLDDGGLELT-KYAIEKHEPDNNRWIKVADVDR-DVETYCIQKL 1731
+ + T++ K G E+T K+ + E K++ D + +
Sbjct: 5514 SIDVTQGDPATLQVK---FSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEK 5570
Query: 1732 NENCEYMFRVIAQNPVGFS 1750
++ EY F V QN VG S
Sbjct: 5571 KDSGEYTFEV--QNDVGRS 5587
Score = 248 bits (608), Expect = 1e-64
Identities = 245/1035 (23%), Positives = 430/1035 (41%), Gaps = 63/1035 (6%)
Query: 664 DIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPI 723
++ W F+ + + DE D + Y V+ N + Q G Y A+N G+ +
Sbjct: 4317 EVNWYFENKLVPSDEKFKCL--QDQNTYTLVIDKVNTEDHQ-GEYVCEALNDSGKTATSA 4373
Query: 724 VLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPT 780
K+ ++ P + ++ + V G + ++ P W K + +
Sbjct: 4374 --KLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSI 4431
Query: 781 KSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQ 840
+S S+ IL+ + V D G YT KA N G +A +TV E A PP F++R +
Sbjct: 4432 RSSKYISSLEILRTQVV-DCGEYTCKASNEYGSVSCTATLTVTE-----AYPPTFLSRPK 4485
Query: 841 EITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELV-ITNVDSEI 899
+T K + VT PV W ++ +SPS + D EN ++ ++N+ +
Sbjct: 4486 SLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWKIS-DAENKHILELSNLTIQ- 4543
Query: 900 DSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VS 957
D G Y C ASN G A + I ++K F+K L+ ++ K V LECQ V+
Sbjct: 4544 DRGVYSCKASNKFGADICQAELII-IDKPHFIKELEP-VQSAINKKVHLECQVDEDRKVT 4601
Query: 958 TKWYHNKKEIS-GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI 1016
W + +++ G D++ I E + D G C ++ S+ T+
Sbjct: 4602 VTWSKDGQKLPPGKDYK-ICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTV 4660
Query: 1017 ---PEFIRKLQ-DFEVKEKDVAILEVEIN-SETADVVWERDG-EIIKPKKNKYDFEKRGH 1070
P F++K+ + + + A L ++ S V W ++ E+ + + F
Sbjct: 4661 REPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEA 4720
Query: 1071 IRKLYIRNTSVHDEGEYSC-ILRD---ESCTAEVTVVELPPEIITRLQNQKVNKGNKATF 1126
I L I + V D G YSC + D +SC+ E+ + E PP I L+ + +G A
Sbjct: 4721 I--LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKE-PPSFIKTLEPADIVRGTNALL 4777
Query: 1127 EIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVG 1181
+ E++ G + WFKD +I+ S +L L+I+ + D GEY C EVG
Sbjct: 4778 QCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 4837
Query: 1182 NSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEK 1241
C A ++EP F ++ + I + T E + VTW K + VI + K
Sbjct: 4838 KCGCMATHLLKEPP-TFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGK 4896
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLL-DAKSTTKLKVEVVEFPPKIVDYEREYRIK 1300
+ LII +YTC+ +A S T + +V+ P KI++ ++
Sbjct: 4897 IKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVT 4956
Query: 1301 RGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKL 1360
G TL P+ +W + + + K + S + A L E D+G Y
Sbjct: 4957 AGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTF 5016
Query: 1361 RLENNCGHADVEMNVTILDKPSPP--GKPNILEIDSSSINICWDEPENTGNSTI-IYYVV 1417
+ N G + E T+LD+ P KP + +DS C + + G+ + + +
Sbjct: 5017 EISNEVGSSSCETTFTVLDRDIAPFFTKP-LRNVDSVVNGTCRLDCKIAGSLPMRVSWFK 5075
Query: 1418 EYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ +EI ++ + + T + I + N + F A N V D+S +++E
Sbjct: 5076 DGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGAL----IVQE 5131
Query: 1477 TKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXX 1535
V KP K++ P + L F G + W++ K+L + + Y +
Sbjct: 5132 PP---SFVTKPGSKDVL--PGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEAL 5186
Query: 1536 XXXXXX----XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C N G VE S + +++ P + + Q K GD
Sbjct: 5187 ESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKE-PATFVEKLEPSQLLKKGDATQ 5245
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ + G PP ++ W+ N +++ ++ ++ E T+V+R+ ++ S +Y EA N A
Sbjct: 5246 LACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEA 5305
Query: 1652 GTSSVEVTLKVYDKP 1666
G+ + V + P
Sbjct: 5306 GSDHCSSIVIVKESP 5320
Score = 248 bits (606), Expect = 2e-64
Identities = 190/706 (26%), Positives = 301/706 (42%), Gaps = 43/706 (6%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK---HTKPS-----IDSKSASLTIKKVE 1351
K GS + + + P P W + K K K H P S+ + I + +
Sbjct: 16750 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECK 16809
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+ G Y + +N G V ++D P PP + +I S + W P++ G
Sbjct: 16810 RSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDR 16869
Query: 1412 IIYYVVEYQEIDTTEWISVK-NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE- 1469
I YV+E + ID W V + T + +L + Y FR A N I ET +
Sbjct: 16870 IKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQR 16929
Query: 1470 ------YYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
Y K++ + K +++ +P ++ + + + + + W G K +
Sbjct: 16930 TTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVEC-LAWDPTGTKKE 16988
Query: 1524 TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ--QKPVITISNE 1578
+ + ++ A N G + S VG Q+P + S
Sbjct: 16989 AWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSI- 17047
Query: 1579 DIKQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE-------YNITTKEKTSV 1629
D+K+ +V G + A I+G+P P + W+K K ++KE N + T
Sbjct: 17048 DLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCT 17107
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKP 1689
+ I + +RS + YTI A N GT+S E+ L V +P P GP+ +S + +T+ W P
Sbjct: 17108 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFP 17167
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGF 1749
P DDGG ++T Y IEK E + W+ V+ ++ TY I KL E EY+FR++AQN G
Sbjct: 17168 PKDDGGSKITNYVIEKREANRKTWVHVSSEPKEC-TYTIPKLLEGHEYVFRIMAQNKYGI 17226
Query: 1750 SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ- 1808
E L+SEP + VP + S+ + W E +GGSP+ Y +E+K
Sbjct: 17227 GEPLDSEPETARNLFSVPG-APDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDT 17285
Query: 1809 EGKKWK------XXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKT 1862
K+WK ++ L + YQFR+YA N G D T
Sbjct: 17286 TSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDP 17345
Query: 1863 LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
+ PP P V++ T S L+W+ P +GGS +T YI+E+K + W K
Sbjct: 17346 IAPPGPPFP-KVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRG 17404
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
+ + +KE FR+SA N G+ P E V +E + SP
Sbjct: 17405 TKLVVTGLKEGAFYKFRVSAVNIAGIGEPGEVTDV-IEMKDRLVSP 17449
Score = 247 bits (605), Expect = 3e-64
Identities = 188/685 (27%), Positives = 304/685 (44%), Gaps = 31/685 (4%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKII-KKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
K G DV +L+ ++ P P W + K + +++ + DS S LTI +V D G Y
Sbjct: 28211 KAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSL-LTIPQVTRNDTGKY 28269
Query: 1359 KLRLENNCGHADVE-MNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
L +EN G ++V +LD P+ K + + ++ + WD P G S II YV+
Sbjct: 28270 ILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVI 28329
Query: 1418 EYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
E ++ W V + + T + +L + + FR A NE+ I + ETTE +K
Sbjct: 28330 EKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTE---PVKA 28386
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTC--IFGGVPQPKVTWYRDGKKLKT-AKATYENRX 1533
++ +P + +K+ +T+ + + T GG + R GK +T + A
Sbjct: 28387 AEVPAPIRDLSMKD-STKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTC 28445
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQ------KHKVG 1587
++ A N+ G + + I K +I D+ ++G
Sbjct: 28446 EIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIG 28505
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
+ +G P P + W K+G L+ + + E + IK K+ H KYT+
Sbjct: 28506 HNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVIL 28565
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
N +V +T+ PSKP+GP+ EI +SV + W P D+GG E+T Y+IEK E
Sbjct: 28566 DNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRE 28625
Query: 1708 PDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV 1766
W V + V R T+ + L ++ EY FRV A+N G S+ L S IV K +
Sbjct: 28626 TSQTNWKMVCSSVAR--TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRI 28683
Query: 1767 PSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXX--XXXX 1823
P + ++ + +TW +GGS + + VE K+ W+
Sbjct: 28684 PG-PPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGRE 28742
Query: 1824 ARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG-KTLTPPSQPRNFVVSESTSRSV 1882
R L YQFR+YA N G S P + K T+ + PP P +++ + T ++
Sbjct: 28743 YRATGLVEGLDYQFRVYAENSAGLSSP-SDPSKFTLAVSPVDPPGTP-DYI--DVTRETI 28798
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TLKW P +GGS I Y IE K + W + S ++ + + D FRI A
Sbjct: 28799 TLKWNPPLRDGGSKIVGYSIE-KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIA 28857
Query: 1943 ENTVG-VSLPTESQSVRLEKHATVP 1966
N VG +S P++S + + + VP
Sbjct: 28858 RNAVGTISPPSQSSGIIMTRDENVP 28882
Score = 245 bits (600), Expect = 1e-63
Identities = 188/708 (26%), Positives = 303/708 (42%), Gaps = 35/708 (4%)
Query: 1287 PPKI---VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
PP+I D + ++ + + L V + P+P +W I+ + + S
Sbjct: 26031 PPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTD--RAQIEVTSSFT 26088
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDE 1403
L I V D+G Y L LENN G +NV +LD PS P I E+ S+ + W+
Sbjct: 26089 MLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEP 26148
Query: 1404 PENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
P G + I Y+VE +E + ++ N TKT I+NL+ SY FR A NE I
Sbjct: 26149 PLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIG 26208
Query: 1463 DASETTEYYKV----IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
+ETTE KV + ++ V + I E E + I G V + + +
Sbjct: 26209 LPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQT---KG 26265
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC----VVG--IQQKPV 1572
+K T T ++ A N+ G + V+ I+ KP
Sbjct: 26266 SEKWSTC--TQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPS 26323
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + K + ++ + +G P V W K+G L+ N+++ + + + I
Sbjct: 26324 VELPFHTFNVKAR--EQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSI 26381
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLD 1692
KE + Y + SN+AG+ +V +T+ V D+P P GP+ + E+S +S+TI W PP
Sbjct: 26382 KEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPP-GPIRIDEVSCDSITISWNPPEY 26440
Query: 1693 DGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
DGG +++ Y +EK E + W V+ + I +L EY FRV A+N G S
Sbjct: 26441 DGGCQISNYIVEKKETTSTTWHIVSQAVART-SIKIVRLTTGSEYQFRVCAENRYGKSSY 26499
Query: 1753 LESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK- 1811
ES +V + P ++ +TW +GGS +I Y +E K+
Sbjct: 26500 SESSAVVAEYPFSPPGPPGTPKVVHA-TKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSI 26558
Query: 1812 KWKXX--XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQP 1869
W ++ L Y++R+YA N G S + + PP QP
Sbjct: 26559 LWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQP 26618
Query: 1870 RNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIEN 1929
V+ T +SV+LKW++P +GG+ IT YI+E + + W K +
Sbjct: 26619 E---VTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTE 26675
Query: 1930 IKEKDEIIFRISAENTV-GVSLPTESQSVRLEKHATVPSPPTAPLEIR 1976
+ E FR+ A N VS P+ES + K PP ++++
Sbjct: 26676 LTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDV--EPPRVMMDVK 26721
Score = 245 bits (599), Expect = 2e-63
Identities = 274/1209 (22%), Positives = 485/1209 (40%), Gaps = 96/1209 (7%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
VEK + + + EC V G P ++ W + I PS+ F M +++ NVA+ I+
Sbjct: 6071 VEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFEN-NVASFRIQS 6129
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGI 632
V +D+G +T +N F SS+ + + + + I
Sbjct: 6130 VMKQDSGQYTFKVEN--DFGSSSCDAYLRV-------------------------LDQNI 6162
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F+KK GS I +EC++ W G+EI + S H
Sbjct: 6163 PPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEI----STSAKYRLVCHERS 6218
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ-VIEPLKSMIVRQGES 751
L++ N++ YT N G+ + +L +K EPP +++P + + +
Sbjct: 6219 VSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVK----EPPSFLVKPGRQQAIPDS-T 6273
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAEN 809
V A + G P I W K++ + + P G S + L V G YT N
Sbjct: 6274 VEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 6333
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWYR 868
G + ++ V EPP F+ + + + + G + +L ++ +P + W+R
Sbjct: 6334 DVGSDSCTTMLLV-------TEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFR 6386
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
N + S+ F + + N+ +E DSGD+ C A N AG +S +V + V
Sbjct: 6387 NEHELPASDKYRMTFIDSVAVIQMNNLSTE-DSGDFICEAQNPAGSTSCSTKVIVKEPPV 6445
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
ET + V LEC+ S T WY +K+++ +I +
Sbjct: 6446 --FSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHI 6503
Query: 987 XXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-S 1042
D+G C +++ +T V + P F+ KL V + A L+ I +
Sbjct: 6504 LNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGA 6563
Query: 1043 ETADVVWERDGE-IIKPKKN-KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE- 1099
+ V W ++ E +I+ +N + F + ++ L + G+Y C ++++ E
Sbjct: 6564 QPIFVQWLKEKEEVIRESENIRITFVE--NVATLQFAKAEPANAGKYICQIKNDGGMEEN 6621
Query: 1100 -VTVVELPPEIITRLQN-QKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTI 1156
T++ L P +I V G T E ++ L V W+KDG + S + +
Sbjct: 6622 MATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSF 6681
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSI--NFTLRLPEFILVPA 1210
K L+I + DAG Y+ +V G S CTA++ V + ++ +FT RL V
Sbjct: 6682 YNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGV-L 6740
Query: 1211 NTDAYLTVEIPDET-LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
L ++ + + V W+ +K+ I K+ TL + D YTCV
Sbjct: 6741 GASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCV 6800
Query: 1270 LLDAKSTTKLK-VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
+ + + + V V+ PP V + G +VT + P W ++ +
Sbjct: 6801 AANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGAREL 6860
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN 1388
K + A L + ++ + +G Y + NN G A + + + + + +
Sbjct: 6861 VKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLS 6920
Query: 1389 ILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNS 1447
++ I E TG I + + + I T+E ++ +T +T I + NS
Sbjct: 6921 DHSVEPGKSIIL--ESTYTGTLPISVTWKKDGFNITTSEKCNI--VTTEKTCILEI-LNS 6975
Query: 1448 SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
+ R E++ ++A + + T ++ P L+ + + + L C G
Sbjct: 6976 TKRDAGQYSCEIE-NEAGR--DVCGALVST-LEPPYFVTELEPLEAAVGDSVSLQCQVAG 7031
Query: 1508 VPQPKVTWYRDGKKLKTAKA--TY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
P+ V+WY+ KL+ TY N Y C A N G +
Sbjct: 7032 TPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKT 7091
Query: 1564 VVGIQQK---PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
V IQ++ P +DI+Q VG +T + G P +V WY++G L +D+
Sbjct: 7092 VFRIQERQLPPSFARQLKDIEQT--VGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQ 7149
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP---EGPVIMRE 1677
+ + + ++I + SHS +Y+ ASN GT+S L + P PV +
Sbjct: 7150 TSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDV 7209
Query: 1678 ISRESVTIE 1686
I+ ES E
Sbjct: 7210 IAGESADFE 7218
Score = 244 bits (598), Expect = 2e-63
Identities = 242/1086 (22%), Positives = 448/1086 (41%), Gaps = 65/1086 (5%)
Query: 633 PPTFSKKPK-AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PP F KK + ++ V + EC++ PE + W EI ++ +
Sbjct: 8231 PPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSV--- 8287
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+VL++ N+ G YT A N G AS LK+K EPP + + +G
Sbjct: 8288 -AVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVK----EPPIFRKKPHPIETLKGAD 8342
Query: 752 VILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
V L ++ G P ++W K+ + + K S+ SI IL D G Y KA
Sbjct: 8343 VHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAA-DIGEYQCKAT 8401
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
N G I ++ P P F+ + +I+ ++L + S+ W++
Sbjct: 8402 NDVGSDTCVGSIALKAP-------PRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFK 8454
Query: 869 NN-EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ EI+ S+ I ++ ENI + + ++G Y C N AG A +++ +E
Sbjct: 8455 DKGEIVRESDNIWISYS-ENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV-LEP 8512
Query: 928 VTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
T V+ +S + G T LEC + T +STKW+ + KE++ + +I +
Sbjct: 8513 ATIVEK-PESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLK 8571
Query: 986 XXXXXXXDVGVIKCIV-----KDQETSTMLVVKETIP-EFIRKLQDFEVKEKDVAILEVE 1039
D GV V KD T+++ V T+P F RKL++ ++E +
Sbjct: 8572 IINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECK 8631
Query: 1040 I-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----E 1094
+ S V W +G I + KY + L + D G+Y+CI + +
Sbjct: 8632 VYGSPPISVSWFHEGNEISSGR-KYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSD 8690
Query: 1095 SCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA--LVRWFKDGSEIQFSNHI 1152
C+A +TV E PP + + V G TF + KG V WFK SE+ +
Sbjct: 8691 ECSAPLTVRE-PPSFVQKPDPMDVLTGTNVTFT-SIVKGTPPFSVSWFKGSSELVPGDRC 8748
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFILV 1208
++++ +L+++D D +GEY+C E G + CT L ++ P+ F RL ++ +
Sbjct: 8749 NVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPA-KFVKRLNDYSIE 8807
Query: 1209 PANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC 1268
+ VTW K + +++ + + K L I T +D +Y C
Sbjct: 8808 KGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNC 8867
Query: 1269 VLLDA--KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
+ +A K + ++ ++E PP V ++ G +L P+ W
Sbjct: 8868 YIENASGKDSCSAQILILE-PPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDT 8926
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
++ K + A+L +V+ D+G Y + EN+ G +T+ ++ PP
Sbjct: 8927 KLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSF 8986
Query: 1387 PNILEIDSSSIN--ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLK 1444
L ++ + +D + + + + + + + + + T T + K
Sbjct: 8987 SRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTAT-LNIFK 9045
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI 1504
T+ S + I AS + ++ E K P + L + E + C
Sbjct: 9046 TDRSLAGQYSCTATNPIGSASSSARL--ILTEGK-NPPFFDIRLAPVDAVVGESADFECH 9102
Query: 1505 FGGVPQPKVTWYRDGKKLKTA---KATY-ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
G KV+W +D +++++ + +Y EN Y C A N+ G+
Sbjct: 9103 VTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDS 9162
Query: 1561 TSCVVGIQQKPVITISNEDIKQ--KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + I+++ + + + + + G+ + + + G P V WYKN +++
Sbjct: 9163 CTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSN 9222
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
IT K T V+++++ + + YT + SN AG++ ++ V +P KP PV + +
Sbjct: 9223 CEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSI-VIKEPKKP--PVFDQHL 9279
Query: 1679 SRESVT 1684
+ +V+
Sbjct: 9280 TPVTVS 9285
Score = 244 bits (596), Expect = 4e-63
Identities = 272/1208 (22%), Positives = 492/1208 (40%), Gaps = 98/1208 (8%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
+EK P G+ EC V G P WF+ + + + + VA+L I
Sbjct: 7575 IEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFIN-KVASLKIPC 7633
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGI 632
D G ++ KN+ G ++ T +S H S+ V
Sbjct: 7634 AEMSDKGLYSFEVKNSVGKSNCT--------VSVHVSDRIV------------------- 7666
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F +K K G+ ++LECR+ + W G EIV + ++ C
Sbjct: 7667 PPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENV---C 7723
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L ++ ++ G YT VA N G VL + +EPP + S+ V G S+
Sbjct: 7724 T-LNLSLLEPSDTGIYTCVAANVAGSDECSAVLTV----QEPPSFEQTPDSVEVLPGMSL 7778
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAENS 810
++ + G P + W K ++ + + + +T L+ +V+ + G Y+ N
Sbjct: 7779 TFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTND 7838
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G A + + V+EP F+ R + +V+ I L A T P S++W ++
Sbjct: 7839 AGSASCTTHLFVKEPA-------TFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDE 7891
Query: 871 EIISPSE--TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
+IS SE +IT +E++ + ++ D Y C+ N AG+ A V++ +E
Sbjct: 7892 YLISQSERCSITMTEKSTILEILESTIE---DYAQYSCLIENEAGQDICEALVSV-LEPP 7947
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
F++ L+ E G+ L+C+ T + WY ++ ++ +
Sbjct: 7948 YFIEPLE-HVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVI 8006
Query: 987 XXXXXXDVGVIKCIVKDQ----ETSTMLVVKE--TIPEFIRKLQDFEVKEKDVAILEVEI 1040
DVG C + +S +LV+KE P F RKL+D E I
Sbjct: 8007 NKVDHSDVGEYSCKADNSVGAVASSAVLVIKERKLPPFFARKLKDVHETLGFPVAFECRI 8066
Query: 1041 N-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N SE V W +DG ++K N ++ L I T G+Y+C + TA
Sbjct: 8067 NGSEPLQVSWYKDGVLLKDDAN-LQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTAS 8125
Query: 1100 ------VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
++ E+PP + + + G TF+ +T G A ++ W KD EI+ +
Sbjct: 8126 SSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVT-GTAPIKITWAKDNREIRPGGN 8184
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRL-PEFI 1206
++T+ L + DAG+Y+C G C+A L V+EP F +L P I
Sbjct: 8185 YKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAHLGVQEPP-RFIKKLEPSRI 8243
Query: 1207 LVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
+ Y + V WYK ++ I+++ KF + L + + +D +Y
Sbjct: 8244 VKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDY 8303
Query: 1267 TCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS 1325
TC +A + + V+ PP +G+DV L + Q P + W +
Sbjct: 8304 TCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDK 8363
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
+ ++ K K ++ S+ I V+ D G Y+ + N+ G ++ + P
Sbjct: 8364 RELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVK 8423
Query: 1386 K-PNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISV-KNITKTQTSIQ 1441
K +I + + + E +++++ + + + ++ WIS +NI Q S
Sbjct: 8424 KLSDISTVVGKEVQL-QTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFS-- 8480
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIEL 1501
++ ++ ++ N+ + + T V++ I VEKP ++I + L
Sbjct: 8481 RVEPANAGKYTCQIKNDAGMQECFAT---LSVLEPATI----VEKP-ESIKVTTGDTCTL 8532
Query: 1502 TCIFGGVPQPKVTWYRDGKKLKT---AKATYENRXXXXXXXXXX-XXXXXYKCIAFNDHG 1557
C G P+ W++DGK+L + K ++ N+ Y N G
Sbjct: 8533 ECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVG 8592
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
+ + + + + V +K+ + + G ++ + G PP V W+ GN++ +
Sbjct: 8593 KDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSG 8652
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
++Y T + T + + L+ S S YT A+N AG+ L V + PS + P M
Sbjct: 8653 RKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMD 8712
Query: 1677 EISRESVT 1684
++ +VT
Sbjct: 8713 VLTGTNVT 8720
Score = 243 bits (595), Expect = 5e-63
Identities = 244/1062 (22%), Positives = 433/1062 (40%), Gaps = 60/1062 (5%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L+C++ ++W G+EI + +A + L+I V G +T A
Sbjct: 5059 LDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGT----ASLEIIRVDMNDAGNFTCRA 5114
Query: 713 VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN 772
N G L ++ EPP + S V G +V L + G+ TI W K N
Sbjct: 5115 TNSVGSKDSSGALIVQ----EPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGN 5170
Query: 773 KPVKALPTK--SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENA 830
K + + + + S L K D G YT K N G E SA + V+EP
Sbjct: 5171 KELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPAT--- 5227
Query: 831 EPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE 889
F+ + + + +KG +L +VT P ITW+ N+ I S +F
Sbjct: 5228 ----FVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAV 5283
Query: 890 LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVIL- 948
L +T+V E DSG+Y C A N AG S H + + I E F K + +E ++L
Sbjct: 5284 LRLTDVGIE-DSGEYMCEAQNEAG-SDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLA 5341
Query: 949 ECQTSHTVSTKWYHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETS 1007
E + W+ + + SG ++ IQ+ D G +C V ++ S
Sbjct: 5342 EVAGTPPFEITWFKDNTILRSGRKYKTFIQD-HLVSLQILKFVAADAGEYQCRVTNEVGS 5400
Query: 1008 TMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKN-K 1062
++ + T+ P FI+K++ A + + S V W +D + I N +
Sbjct: 5401 SICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIR 5460
Query: 1063 YDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKV 1118
FE ++ LY+ V +G+Y C ++++ C+A ++V E P I + V
Sbjct: 5461 MTFEN--NVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKE-PATITEEAVSIDV 5517
Query: 1119 NKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
+G+ AT +++ + + +WFKDG E+ + ++++ LKI + D+GEY+
Sbjct: 5518 TQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYT 5577
Query: 1178 CEV----GNSKCTAILTVEEPSI--NFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYK 1231
EV G S C A + V + I +FT +L + + + + + + W+K
Sbjct: 5578 FEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFK 5637
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKI 1290
I +EK+ L I + D YTC + + + V+ PP
Sbjct: 5638 DDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYF 5697
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
V+ + + + V L +W ++K + D S SL +
Sbjct: 5698 VEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAA 5757
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNS 1410
+ TD+G Y +L N+ G A + + + + P KP+ + + + + + E + TG
Sbjct: 5758 KATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTF-ECQITGTP 5816
Query: 1411 TI-IYYVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASETT 1468
I + + ++ EI + + I T I + +S + A N+ + S
Sbjct: 5817 KIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIEL 5876
Query: 1469 EYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA- 1527
+ +KE PT + LK + D+EL C G P +VTW ++ ++++++K
Sbjct: 5877 K----VKEP----PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKY 5928
Query: 1528 TYENRXXXXXXXXXX---XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH 1584
T +R Y+CI N+ G S V +++ P E+
Sbjct: 5929 TLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVL 5988
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K + T + G PP + W K+ L+ D I+ + + ++I+ + HS +YT
Sbjct: 5989 KSSATFQST--VAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYT 6046
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+A N +G L V + E + ++ +T+E
Sbjct: 6047 CQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLE 6088
Score = 242 bits (593), Expect = 8e-63
Identities = 215/796 (27%), Positives = 348/796 (43%), Gaps = 54/796 (6%)
Query: 1195 SINFTLRLPEFILVPANTDAYLTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKR 1251
+I +L+LP F L +EIP +++W K ++ T + +
Sbjct: 25236 TIQPSLKLP-FNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST 25294
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
L I++ +DD +YT ++ T L V V+E P V R S +++
Sbjct: 25295 VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVG---PVRFDEVSADFVVI 25351
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL---TIKKVENTDAGIYKLRL--EN 1364
++ P +++ I++K T + SA++ TIK + Y+ R+ EN
Sbjct: 25352 SWEP-PAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAEN 25410
Query: 1365 NCGH-ADVEMNVTILD----KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEY 1419
G A ++ I+ +P PPG P + I + + W EP N G + II Y +E
Sbjct: 25411 RYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQ 25470
Query: 1420 QEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKET 1477
+E ++ W+ + I T+ L Y F+ A N V I S+ +E + +
Sbjct: 25471 KEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF--VARD 25528
Query: 1478 KIQSPTVEKPLKNITTEPNEDIELT--CIFGGVPQPKVTWYRDGKKL----KTAKATYEN 1531
P +P + T N ++ GG K+T Y KK + KA++ N
Sbjct: 25529 PCDPPG--RPEAIVITRNNVTLKWKKPAYDGG---SKITGYIVEKKDLPDGRWMKASFTN 25583
Query: 1532 RXXXXXXXXXXXXXXXY--KCIAFNDHGEV-ETSCVVG-IQQKPVITISNEDIKQKHK-- 1585
Y + IA N G E S G I + I N + K+K
Sbjct: 25584 VLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDV 25643
Query: 1586 ----VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNI-TTKEKTSVIRIKELKRSH 1639
G+ +++ A I G P P+V+W K+G +LE I +T +KT+++ +K+ R+
Sbjct: 25644 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLV-VKDCIRTD 25702
Query: 1640 SSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELT 1699
+Y ++ SN GT S+ +T+KV D+P PEGP+ + ++ E + W PPL DGG ++
Sbjct: 25703 GGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANIS 25762
Query: 1700 KYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV 1759
Y IEK E W +V+ + Y + KL EY+FRV+A N G E LES P+
Sbjct: 25763 HYIIEKRETSRLSWTQVS-TEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVT 25821
Query: 1760 IKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWK--XX 1816
P I +S+ +TW +GG+ I Y +E + +EG +W
Sbjct: 25822 ACNPYK-PPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNK 25880
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE 1876
R+ L+ +Y+FR+ A N G P L PP P N V++
Sbjct: 25881 KTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTD 25940
Query: 1877 STSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV-TVGGSVHEHCIENIKEKDE 1935
++ SV+L W++P +GG+P+ Y++E K WT G + + +KE E
Sbjct: 25941 TSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTE 26000
Query: 1936 IIFRISAENTVGVSLP 1951
FRI A N+ GV P
Sbjct: 26001 YNFRICAINSEGVGEP 26016
Score = 240 bits (588), Expect = 3e-62
Identities = 245/1068 (22%), Positives = 429/1068 (40%), Gaps = 65/1068 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F +KP++Q V+ + + L+ + I W +E+ SV +
Sbjct: 5694 PPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTS---- 5749
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE-PLKSMIVRQGES 751
+ L++ K GTY N G A+ L +K EPPQ I+ P +++R G+S
Sbjct: 5750 TSLELFAAKATDSGTYICQLSNDVGTATSKATLFVK----EPPQFIKKPSPVLVLRNGQS 5805
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI--LKPKKVKDEGVYTLKAEN 809
Q+ G P+ ++W + + A+ + + +V++ G Y +A N
Sbjct: 5806 TTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARN 5865
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G A S + V+EP P FI + + V + ++L VT P +TW +N
Sbjct: 5866 DAGTASCSIELKVKEP-------PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKN 5918
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
N I S+ T L IT D D+G+Y+C+ SN G S RV + E +
Sbjct: 5919 NREIRSSKKYTLTDRVSVFNLHITKCDPS-DTGEYQCIVSNEGGSCSCSTRVALK-EPPS 5976
Query: 930 FVKHLQKSYET-EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
F+K ++ + + T S +S W + + + D+ I
Sbjct: 5977 FIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRS 6036
Query: 989 XXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIRKLQDFEVKEKDVAILE-VEINSE 1043
G C K++ L+V+E + + K + +V EKD LE V +
Sbjct: 6037 VDNGHSGRYTCQAKNESGVERCYAFLLVQEPA-QIVEKAKSVDVTEKDPMTLECVVAGTP 6095
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----SCTAE 1099
V W +DG+ I P + + ++ I++ D G+Y+ + ++ SC A
Sbjct: 6096 ELKVKWLKDGKQIVPSRY-FSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAY 6154
Query: 1100 VTVVE--LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTI 1156
+ V++ +PP +L G+ E +++ + +WFKDG EI S +L
Sbjct: 6155 LRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVC 6214
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPEFILVPANT 1212
+ L++ + +L+D Y+C+V G+ C+ ILTV+EP +F ++ +P +T
Sbjct: 6215 HERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPP-SFLVKPGRQQAIPDST 6273
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC-VLL 1271
+ + + W+K + K + + L + +YTC V
Sbjct: 6274 VEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 6333
Query: 1272 DAKSTTKLKVEVVEFPPKIVD-YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS-KIIK 1329
D S + + +V PPK V E +K G L P+ W N ++
Sbjct: 6334 DVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPA 6393
Query: 1330 KCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI 1389
K+ IDS A + + + D+G + +N G V + + P P I
Sbjct: 6394 SDKYRMTFIDSV-AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPI 6452
Query: 1390 LE-IDSSSINI-CWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTN 1446
+E + ++ +++ C E T +++Y + Q + ++ I+ KN T I N+ T+
Sbjct: 6453 VETLKNAEVSLEC--ELSGTPPFEVVWYKDKRQLRSSKKYKIASKNF-HTSIHILNVDTS 6509
Query: 1447 SSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG 1506
+ A NEV SD T K + P L ++T E EL
Sbjct: 6510 DIGEYHCKAQNEVG-SDTCVCTVKLK-------EPPRFVSKLNSLTVVAGEPAELQASIE 6561
Query: 1507 GVPQPKVTWYRDGKKL----KTAKATY-ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G V W ++ +++ + + T+ EN Y C ND G E
Sbjct: 6562 GAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMEEN 6621
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ + + VI + VG+ + + G P V WYK+G L + +++
Sbjct: 6622 MATLMVLEPAVIVEKAGPMTVT--VGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKF 6679
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
+ K S +RI ++R + YT + N G SS + V D+ P
Sbjct: 6680 SFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPP 6727
Score = 239 bits (585), Expect = 8e-62
Identities = 195/695 (28%), Positives = 293/695 (42%), Gaps = 36/695 (5%)
Query: 1280 KVEVVEFPPKI---VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
K E PP+I D + I+ + L V + P P +W + K
Sbjct: 22777 KAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGE----SLDKA 22832
Query: 1337 SIDSKSAS--LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
SI+S S+ L + V D+G Y L +EN+ G +NV +LD P PP + E+
Sbjct: 22833 SIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTK 22892
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTSIQNLKTNSSYRFRA 1453
+S+ + WD P G S I Y+VE +E + +V N KT + L+ SY FR
Sbjct: 22893 TSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRV 22952
Query: 1454 YAVNEVDISDASETTEYYKVIKET----KIQSPTVEKPLKNITTEPNEDIELTCIFGGVP 1509
A NE I +ET E K + KI V + +++ E E + I G +
Sbjct: 22953 LAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIV 23012
Query: 1510 QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG--EVETSCVVGI 1567
+ + T K T ++ A N+ G + V I
Sbjct: 23013 EMQTKGSDKWATCATVKVT-----EATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVI 23067
Query: 1568 QQKPVITISNEDIKQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE 1625
+ VI + + + V G++ V G P P V W+K+ L+ N + E
Sbjct: 23068 AKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTE 23127
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
S++ IK+ R Y ++ +N+AG + + + V DKP P GPV M E++ +S+T+
Sbjct: 23128 NNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITL 23187
Query: 1686 EWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
W PP DGG + Y +EK + W I A V R C +L CEY FR+ A+
Sbjct: 23188 SWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKAC--RLKTGCEYQFRIAAE 23245
Query: 1745 NPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKV 1804
N G S L SEP V + VP +S+ + W +GGS +I Y +
Sbjct: 23246 NRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLS-SRDSMEVQWNEPISDGGSRVIGYHL 23304
Query: 1805 EIKQEGK-KWKXXXXXXXXXARIQK--LSINTTYQFRIYARNEIGTSLPYTSDDKITIGK 1861
E K+ W + + L Y+FR+ A N +G P +
Sbjct: 23305 ERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARD 23364
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
PP +P +V T SVTL+W +P +GGS IT YI+E K + W K +
Sbjct: 23365 PCDPPGRPEAIIV---TRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMK-ASFTNI 23420
Query: 1922 VHEHC-IENIKEKDEIIFRISAENTVGV-SLPTES 1954
+ H + + E FR+ A N GV S P+ES
Sbjct: 23421 IDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSES 23455
Score = 238 bits (583), Expect = 1e-61
Identities = 195/762 (25%), Positives = 325/762 (42%), Gaps = 47/762 (6%)
Query: 1219 EIPDETLDVTWYKKKSVIEDTEK-FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
+I D + D W + + + K FT+ S + + R C ++ + A+
Sbjct: 19465 KIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQ----VGIGRPAELKE 19520
Query: 1278 KLKVEVVEFPPKIVDYEREYR----IKRGSDVTLLVDYQAFPQPNDEW--IVNSKIIKKC 1331
+K + + PP+I D + R ++ G + L + P P W + +++K
Sbjct: 19521 AIKPKEILEPPEI-DLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRK- 19578
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
+ + A L I D+G Y L L N G V +NV +LD P P + +
Sbjct: 19579 --GQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSD 19636
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTSIQNLKTNSSYR 1450
+ +S ++ W PEN G S + +Y+VE +E D W +V + KT + NL + Y
Sbjct: 19637 VTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYY 19696
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI----FG 1506
FR AVNE ++ + V+ + P + L+ +T L + G
Sbjct: 19697 FRVTAVNEYGPGVPTDVPK--PVLASDPLSEPDPPRKLE-VTEMTKNSATLAWLPPLRDG 19753
Query: 1507 GVP-QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYK--CIAFNDHG-----E 1558
G +T YR+ ++ Y YK A N G E
Sbjct: 19754 GAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPRE 19813
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
E Q P + E I K G + + A + G P P W K +++
Sbjct: 19814 AEGVYEAKEQLLPPKILMPEQITIK--AGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSH 19871
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
+ + +S++ IK++ R S Y++ A N++GT + ++ + V D P P+ P + +I
Sbjct: 19872 LAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDI 19931
Query: 1679 SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWI-KVADVDRDVETYC-IQKLNENCE 1736
++ ++ W PL+DGG +T Y +EK + W+ +A V +T C + KL E
Sbjct: 19932 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASV---TKTSCRVGKLIPGQE 19988
Query: 1737 YMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGG 1796
Y+FRV A+N G SE L S +V + VPS ++ + +++ W + +GG
Sbjct: 19989 YIFRVRAENRFGISEPLTSPKMVAQFPFGVPS-EPKNARVTKVNKDCIFVAWDRPDSDGG 20047
Query: 1797 SPIIDYKVEIKQEGK-KWKXXXXXXXXXARIQKLSI--NTTYQFRIYARNEIGTSLPYTS 1853
SPII Y +E K+ W + Y FRIYA N+ G+S P
Sbjct: 20048 SPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKP 20107
Query: 1854 DDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWT 1913
+ +T + PP +P V++ST V+L W P+ +GGS I Y +E + G W
Sbjct: 20108 TEYVTARMPVDPPGKPEVIDVTKST---VSLIWARPKHDGGSKIIGYFVEACKLPGDKWV 20164
Query: 1914 KIVTVGGSV--HEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
+ T + E+ ++EK + FR A V +S P+E
Sbjct: 20165 RCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSE 20206
Score = 238 bits (583), Expect = 1e-61
Identities = 199/754 (26%), Positives = 323/754 (42%), Gaps = 35/754 (4%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEF 1286
+TW K ++ T + + + TL I++ +DD +Y + + +E+V
Sbjct: 24188 ITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTL 24247
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL- 1345
K + + S ++ + + P + + I++K T D SA++
Sbjct: 24248 D-KPDPPKGPVKFDDVSAESITLSWNP-PLYTGGCQITNYIVQKRDTTTTVWDVVSATVA 24305
Query: 1346 -TIKKVENTDAGI-YKLRL--ENNCGHA-DVEMNVTILD----KPSPPGKPNILEIDSSS 1396
T KV G Y+ R+ EN G + +E + + +P PPG P I S
Sbjct: 24306 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDS 24365
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAY 1454
+ I W EP N G S +I Y +E +E ++ W V I TQ QNL+ Y FR Y
Sbjct: 24366 MVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVY 24425
Query: 1455 AVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG-VPQPKV 1513
A N V + AS+ +E Y + P +P+ E GG + +
Sbjct: 24426 AENIVGVGKASKNSECY--VARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYI 24483
Query: 1514 TWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHGEV-ETSCVVG-IQQ 1569
RD + KA++ N Y + IA N G + + S G I
Sbjct: 24484 VEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITA 24543
Query: 1570 KPVITISNEDIKQKHK------VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITT 1623
K + + + K + G+ + + A + G P P + W + ++E I
Sbjct: 24544 KDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKN 24603
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV 1683
+ +++ +K+ R +Y + ASN AG+ S V +KV D+P PEGPV + ++ E
Sbjct: 24604 TDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKC 24663
Query: 1684 TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
++ W PPL DGG +++ Y +EK E W VA + + + KL E EY+FR++A
Sbjct: 24664 SLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVAS-EVVTNSLKVTKLLEGNEYVFRIMA 24722
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G E LES P+++K +P I +S+ + W + +GGS II Y
Sbjct: 24723 VNKYGVGEPLESAPVLMKNPFVLPG-PPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 24781
Query: 1804 VEIK-QEGKKW--KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
VE + + G +W R+ L+ + Y+FR+ A N G P +
Sbjct: 24782 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKAC 24841
Query: 1861 KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT--V 1918
+ P P N + ++T S+TL W +P +GGS I Y++E + W +IVT
Sbjct: 24842 DPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEW-QIVTPQT 24900
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
G V I + E E R+ A N VG+ T
Sbjct: 24901 GLRVTRFEISKLTEHQEYKIRVCALNKVGLGEAT 24934
Score = 236 bits (578), Expect = 5e-61
Identities = 240/1090 (22%), Positives = 432/1090 (39%), Gaps = 63/1090 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P +KP+ V G+ LEC + PE W G E+ D + + +
Sbjct: 7571 PARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKV---- 7626
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ LKI + +G Y+ N G+++ + + + + PP I LK + G SV
Sbjct: 7627 ASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV-SDRIVPPSFIRKLKDVNAILGASV 7685
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAENS 810
+L +V G+ ++ W ++ + + P + ++ L ++ D G+YT A N
Sbjct: 7686 VLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANV 7745
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G E SAV+TV+EP P F + V ++ + + P + W++ +
Sbjct: 7746 AGSDECSAVLTVQEP-------PSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGS 7798
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
+ P E+ + + EL + V ++SGDY C+ +N AG +S + + E TF
Sbjct: 7799 RELVPGESCNISLEDFVTELELFEVQP-LESGDYSCLVTNDAGSASCTTHLFVK-EPATF 7856
Query: 931 VKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
VK L + E G ++LE + T +S W ++ IS + I +
Sbjct: 7857 VKRLA-DFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILE 7915
Query: 989 XXXXDVGVIKCIVKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SET 1044
D C++++ Q+ LV P FI L+ E + A L+ +++ +
Sbjct: 7916 STIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPE 7975
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----CTAEV 1100
+ W ++ ++ Y + + ++ L I D GEYSC D S ++ V
Sbjct: 7976 IRISWYKEHTKLRSAP-AYKMQFKNNVASLVINKVDHSDVGEYSC-KADNSVGAVASSAV 8033
Query: 1101 TVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTI 1156
V++ LPP +L++ G FE + + L V W+KDG ++ ++Q +
Sbjct: 8034 LVIKERKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSF 8093
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA------ILTVEEPSINFTLRLPEFILVPA 1210
L+I D G+Y+C N TA IL+ E F L+ L
Sbjct: 8094 VHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALG 8153
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
+ + + +TW K I + + TL + K + D +YTC
Sbjct: 8154 ESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYA 8213
Query: 1271 LDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLL-VDYQAFPQPNDEWIVNSKII 1328
+ + V+ PP+ + RI + + T P+ W + I
Sbjct: 8214 SNIAGKDSCSAHLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEI 8273
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN 1388
++ + S A L + + D+G Y N G A ++ + + P KP+
Sbjct: 8274 QESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPH 8333
Query: 1389 ILE-IDSSSINI-CWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTN 1446
+E + + +++ C E + T + +Y + + ++ + T I N+
Sbjct: 8334 PIETLKGADVHLEC--ELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAA 8391
Query: 1447 SSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG 1506
++ A N+V S+T +K P K L +I+T ++++L
Sbjct: 8392 DIGEYQCKATNDV----GSDTCVGSIALKAP----PRFVKKLSDISTVVGKEVQLQTTIE 8443
Query: 1507 GVPQPKVTWYRD-GKKLKTAKATY----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G V W++D G+ ++ + + EN Y C ND G E
Sbjct: 8444 GAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQEC 8503
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ + + I E IK GD + + G P W+K+G +L +D +Y I
Sbjct: 8504 FATLSVLEPATIVEKPESIKVT--TGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKI 8561
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE---I 1678
+ K S ++I + S S Y+ E N G S +L+V D+ P ++E +
Sbjct: 8562 SFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL 8621
Query: 1679 SRESVTIEWK 1688
S SV +E K
Sbjct: 8622 SGSSVVMECK 8631
Score = 235 bits (574), Expect = 2e-60
Identities = 255/1071 (23%), Positives = 432/1071 (40%), Gaps = 75/1071 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F KK + S + + P I WL + + D+N+ ++ +
Sbjct: 5974 PPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSV---- 6029
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L+I +V G YT A N G L ++ EP Q++E KS+ V + + +
Sbjct: 6030 ATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQ----EPAQIVEKAKSVDVTEKDPM 6085
Query: 753 ILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L V G P + W K+ K P + + + S I K +D G YT K EN
Sbjct: 6086 TLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMK-QDSGQYTFKVEN 6144
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G + A + V ++N PP F + ++ +I + +V+ + S W+++
Sbjct: 6145 DFGSSSCDAYLRV---LDQNI-PPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKD 6200
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ IS S ++ L + N++ E D+ +Y C SN AG + +T+
Sbjct: 6201 GKEISTSAKYRLVCHERSVSLEVNNLELE-DTANYTCKVSNVAGDDACSGILTVKEPPSF 6259
Query: 930 FVKHLQKSY---ETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
VK ++ T E K ++ + + KW+ + E+ I EG
Sbjct: 6260 LVKPGRQQAIPDSTVEFKAIL---KGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNL 6316
Query: 987 XXXXXXDVGVIKCIVKDQETS----TMLVVKETIPEFIRKLQDFE-VKEKDVAILEVEI- 1040
G C V + S TML+V E P+F++KL+ + VK D + LE +I
Sbjct: 6317 YSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEP-PKFVKKLEASKIVKAGDSSRLECKIA 6375
Query: 1041 NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----SC 1096
S VVW R+ + P +KY + + + N S D G++ C ++ SC
Sbjct: 6376 GSPEIRVVWFRNEHEL-PASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSC 6434
Query: 1097 TAEVTVVELP-----PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSN 1150
+ +V V E P P I+ L+N +V+ E EL+ V W+KD +++ S
Sbjct: 6435 STKVIVKEPPVFSSFPPIVETLKNAEVS------LECELSGTPPFEVVWYKDKRQLRSSK 6488
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFI 1206
++ + I + D D GEY C EVG+ C + ++EP F +L
Sbjct: 6489 KYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPP-RFVSKLNSLT 6547
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQC 1264
+V A A L I + + V W K+K VI ++E + TL K +
Sbjct: 6548 VV-AGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAG 6606
Query: 1265 EYTCVLL-DAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
+Y C + D + +V P IV+ + G TL P+ + EW
Sbjct: 6607 KYICQIKNDGGMEENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYK 6666
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
+ K++ + K S +K +SL I VE DAG Y +++NN G + V + D+ P
Sbjct: 6667 DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVP 6726
Query: 1384 PGKPNILEIDSSSINI-CWDEPENTGNSTIIYYVVEYQEIDTTEWIS-VKNITKTQTSIQ 1441
P L+ + C E + G+S I V + E T+ +S K T ++
Sbjct: 6727 PSFTRRLKNTGGVLGASCILECKVAGSSPI--SVAWFHE--KTKIVSGAKYQTTFSDNVC 6782
Query: 1442 NLKTNS--SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDI 1499
L+ NS S Y +++ + E T + P+ K + + P +++
Sbjct: 6783 TLQLNSLDSSDMGNYTCVAANVAGSDECRAVL-----TVQEPPSFVKEPEPLEVLPGKNV 6837
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENR-XXXXXXXXXXXXXXXYKCIAFND 1555
T + G P KV W+R ++L +E+ Y C+ N+
Sbjct: 6838 TFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNN 6897
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G + SC + K + G ++ + G P V W K+G +
Sbjct: 6898 AG--QASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITT 6955
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
++ NI T EKT ++ I + + +Y+ E N AG + + P
Sbjct: 6956 SEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPP 7006
Score = 233 bits (569), Expect = 7e-60
Identities = 254/1091 (23%), Positives = 436/1091 (39%), Gaps = 71/1091 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
IPP+F+KK K +GS I LEC + I W +EI E + H
Sbjct: 5600 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFS----FHDN 5655
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+ L+I+ ++ GTYT A N+ G L + KEPP +E +S V
Sbjct: 5656 TAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTV----KEPPYFVEKPQSQDVNPNTR 5711
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKS--DGDTHSITILKPKKVKDEGVYTLKAEN 809
V L A V G TI W K+NK + + +S DT + L K D G Y + N
Sbjct: 5712 VQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSN 5771
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWYR 868
G A + A + V+ EPP FI + + V G + ++T P ++WY
Sbjct: 5772 DVGTATSKATLFVK-------EPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYL 5824
Query: 869 N-NEIISPSETITQNFDG-ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+ NEI + + DG ++ V+ +SG Y C A N AG +S + + E
Sbjct: 5825 DGNEITAIQKHGISFIDGLATFQISGARVE---NSGTYVCEARNDAGTASCSIELKVK-E 5880
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXX 984
TF++ L K E + V LEC+ + T W N +EI +
Sbjct: 5881 PPTFIREL-KPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNL 5939
Query: 985 XXXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G +CIV ++ ST + +KE P FI+K+++ K A + +
Sbjct: 5940 HITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEP-PSFIKKIENTTTVLKSSATFQSTV 5998
Query: 1041 -NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES---- 1095
S + W +D +I+ N Y + L IR+ G Y+C ++ES
Sbjct: 5999 AGSPPISITWLKDDQILDEDDNVY-ISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVER 6057
Query: 1096 CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQL 1154
C A + V E P +I+ + ++ V + + T E + L V+W KDG +I S + +
Sbjct: 6058 CYAFLLVQE-PAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSM 6116
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSI--NFTLRLPEFILV 1208
+ + +I D+G+Y+ +V G+S C A L V + +I +FT +L + V
Sbjct: 6117 SFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKV 6176
Query: 1209 PANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ ++ ++ + W+K I + K+ L+ + +L + +D YT
Sbjct: 6177 -LGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYT 6235
Query: 1268 CVLLDAKSTTKLK-VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
C + + + V+ PP + + S V + P +W +
Sbjct: 6236 CKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDV 6295
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
+ ++ ++ L + V+ + G Y + N+ G + + + P K
Sbjct: 6296 ELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKK 6355
Query: 1387 ---PNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-SIQN 1442
I++ SS C + + ++++ E+ E+ ++ + I + N
Sbjct: 6356 LEASKIVKAGDSSRLEC--KIAGSPEIRVVWFRNEH-ELPASDKYRMTFIDSVAVIQMNN 6412
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
L T S F A N + S ++KE + S P+ + T N ++ L
Sbjct: 6413 LSTEDSGDFICEAQNPAGSTSCSTKV----IVKEPPVFSSF--PPI--VETLKNAEVSLE 6464
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
C G P +V WY+D ++L+++K A+ Y C A N+ G
Sbjct: 6465 CELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGS 6524
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
C V +++ P + G+ + A IEG P V W K ++ + E
Sbjct: 6525 DTCVCTVKLKEPPRFVSKLNSLTV--VAGEPAELQASIEGAQPIFVQWLKEKEEVIRESE 6582
Query: 1619 -YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
IT E + ++ + + +++ KY + N G TL V + E M
Sbjct: 6583 NIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMEENMATLMVLEPAVIVEKAGPMTV 6642
Query: 1678 ISRESVTIEWK 1688
E+ T+E K
Sbjct: 6643 TVGETCTLECK 6653
Score = 232 bits (568), Expect = 9e-60
Identities = 185/693 (26%), Positives = 284/693 (40%), Gaps = 30/693 (4%)
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
+ R ++ G + + V + P P W ++ +K + + + L I +
Sbjct: 21708 ELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENT--ESFTLLIIPECN 21765
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
D G + + +EN G +NV +LD P P +I S+ + WD P G S
Sbjct: 21766 RYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSR 21825
Query: 1412 IIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
I Y+VE +E + + K + L Y FR A NE I + +ETTE
Sbjct: 21826 ITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTE- 21884
Query: 1471 YKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY-----RDGKKLKTA 1525
+K ++ SP + +IT G K+T Y R G T
Sbjct: 21885 --PVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDG--GSKITGYVIEAQRKGSDQWTH 21940
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV---ETSCVVGIQQKPVITISNEDIKQ 1582
T + ++ +A N G E+ V+ +Q + + I Q
Sbjct: 21941 ITTVKG-LECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQ 21999
Query: 1583 K---HKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSH 1639
K K GD V + G P P V W K L+ + N T ++++ I E RS
Sbjct: 22000 KLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSD 22059
Query: 1640 SSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELT 1699
S Y + A N G +T++V+D P P GP+ E+S + VT W PP +DGG+ ++
Sbjct: 22060 SGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPIS 22119
Query: 1700 KYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
Y +E + D+ W+++A V R TY +L EY FRV AQN G + S I
Sbjct: 22120 NYVVEMRQTDSTTWVELATTVIR--TTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 22177
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXX 1817
V VP + +S+ I+W +GGSPI+ Y VE K+ G W+
Sbjct: 22178 VANYPFKVPG-PPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVS 22236
Query: 1818 XXX--XXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVS 1875
+ L+ Y+FR+ A N G S P + + + PP +P V
Sbjct: 22237 KALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP---VPL 22293
Query: 1876 ESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
T +VTLKW +PE GG IT+YI+E + + W K +E + + E
Sbjct: 22294 NITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAA 22353
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
FR+ A+N G P S + V +P
Sbjct: 22354 YEFRVIAKNAAGAISPPSEPSDAITCRDDVEAP 22386
Score = 232 bits (568), Expect = 9e-60
Identities = 197/760 (25%), Positives = 319/760 (41%), Gaps = 45/760 (5%)
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
+ K R I + D CE T + K+ +L ++ ++++ + ++ G+ +
Sbjct: 29250 EYKFRVSAINGAGKGDSCEVTGTI---KAVDRLTAPELDID---ANFKQTHVVRAGASIR 29303
Query: 1307 LLVDYQAFPQPNDEWIV--NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLEN 1364
L + YQ P P W ++ ++ HT S ++LT++ DAG Y L +EN
Sbjct: 29304 LFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSF----STLTVENCNRNDAGKYTLTVEN 29359
Query: 1365 NCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
N G + V +LD P PPG ++ S + WD P G + I +YVVE +E
Sbjct: 29360 NSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASR 29419
Query: 1425 TEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT 1483
W + + T+ + +L Y FR AVNE + E E + I T + P
Sbjct: 29420 RSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVG---EPYEMPEPIVAT--EQPA 29474
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA----KATYENRXXXXXXX 1539
+ L + T + + ++T Y + K + +A + +
Sbjct: 29475 PPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVER 29534
Query: 1540 XXXXXXXXYKCIAFNDHG-----EVETSCVVGIQQ-KPVIT---ISNEDIKQKHKVGDEW 1590
++ A ND G E +S ++ Q +P I+N+ I K G +
Sbjct: 29535 LVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCK--AGSPF 29592
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
+ I G P P+V W +L+ +ITT + + + +K+ R S +Y + NT
Sbjct: 29593 TIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 29652
Query: 1651 AGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN 1710
AG + VT+ V +P GP+ + +S ES + W P D GG E+T Y +EK E
Sbjct: 29653 AGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGT 29712
Query: 1711 NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
W V + + + L + EY FRV ++N G S+ LES PI+ + VP
Sbjct: 29713 TAWQLVNSSVKRTQIK-VTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPF-VPPSA 29770
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KW--KXXXXXXXXXARIQ 1827
+ ++ I W +GGS II Y VE K+ W + ++
Sbjct: 29771 PTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVT 29830
Query: 1828 KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWT 1887
L YQFR YA N G S + I + P +P V++ T +V+L W+
Sbjct: 29831 GLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPE---VTDVTRSTVSLIWS 29887
Query: 1888 EPESNGGSPITNYIIEFKTVK---GKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
P +GGS + YIIE K V W K S + + + E D FR+ A+N
Sbjct: 29888 APAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKN 29947
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVM 1984
GV + S+S +PP A L+ R+ G + +
Sbjct: 29948 AAGV-ISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTI 29986
Score = 231 bits (565), Expect = 2e-59
Identities = 221/892 (24%), Positives = 366/892 (41%), Gaps = 44/892 (4%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKSVIEDTEKFTLISDVK 1249
VE P + ++ + I+V A + +I L V +W K IE+ + +IS
Sbjct: 26711 VEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN 26770
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV--EVVEFP-PKIVDYEREYRIKRGSDVT 1306
L ++ C D +Y L + T + V +V++ P P E ++
Sbjct: 26771 HTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLS 26830
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
+ D +IV + T + + S + K+ + I+++ N
Sbjct: 26831 WGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKY 26890
Query: 1367 GHADVEMNVTI--LDK---PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
G + +V I LD PSPP I + S+ +CW PE+ G S I Y++E +E
Sbjct: 26891 GVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERRE 26950
Query: 1422 IDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
++ W+ V K + + L+ Y +R YA N +S SET+ + +
Sbjct: 26951 KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFL 27010
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIF-GGVPQPKVTW-YR-----DGK-KLKTAKAT-YE 1530
SP + + + + +F GG P T Y+ D K +++ + T Y
Sbjct: 27011 PSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYT 27070
Query: 1531 NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDE 1589
K A + + +++P+ I +E K K G
Sbjct: 27071 ISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGAS 27130
Query: 1590 WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
+ +T G P P V+W K L + Y TT +TS + I+ R+ S KYT+ N
Sbjct: 27131 FTMTVPFRGRPVPNVLWSKPDTDLRT-RAYVDTTDSRTS-LTIENANRNDSGKYTLTIQN 27188
Query: 1650 TAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
+S+ + +KV D P P + ++++++ES + W P +DGG + Y IEK E
Sbjct: 27189 VLSAASLTLVVKVLDTPGPPTN-ITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREAS 27247
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
W+ V + + +Y + L E Y FRV +N G E++ V T P
Sbjct: 27248 KKAWVSVTNNCNRL-SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE 27306
Query: 1770 XXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQK 1828
I +SV +TW E +GGS I+ Y VE ++G+K W +
Sbjct: 27307 KLGVTS---ISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSG 27363
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS-QPRNFVVSESTSRS-VTLKW 1886
L N+ Y FR++A N+ G S P + I + L PP +NF R+ LK
Sbjct: 27364 LRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKV 27423
Query: 1887 TEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEK---DEIIFRISAE 1943
P S G P+ + V K+ + T E+ N+KE D + I+A
Sbjct: 27424 DIPIS--GKPLPKVTLSRDGVPLKATMRFNT--EITAENLTINLKESVTADAGRYEITAA 27479
Query: 1944 NTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI 2003
N+ G + V L++ P PPT P+ I + V W P++DGG+ + Y +
Sbjct: 27480 NSSGTT-KAFINIVVLDR----PGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYIL 27534
Query: 2004 AIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
R+ + +W EV T+ + L+ Y RI A N G+S+ ++S
Sbjct: 27535 LKRETSTAVWTEVSATVARTM-MKVMKLTTGEEYQFRIKAENRFGISDHIDS 27585
Score = 230 bits (563), Expect = 4e-59
Identities = 211/770 (27%), Positives = 325/770 (42%), Gaps = 50/770 (6%)
Query: 1216 LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
L V++P T VTW+K ++ T + S L I+ +D Y L +
Sbjct: 23092 LKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTN 23151
Query: 1273 A--KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+ ++ L V V++ P + + S +TL P+ + +N+ I++K
Sbjct: 23152 SAGEAIETLNVIVLDKPGPPTGPVKMDEVTADS-ITLS---WGPPKYDGGSSINNYIVEK 23207
Query: 1331 ---CKHTKPSIDSKSASLTIKKVENTDAGIYKLRL--ENNCGHAD-VEMNVTILDKP--- 1381
T + + A TIK Y+ R+ EN G + + T+ P
Sbjct: 23208 RDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKV 23267
Query: 1382 -SPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQT 1438
PPG P + S+ + W+EP + G S +I Y +E +E ++ W+ + I +T+
Sbjct: 23268 PGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKF 23327
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
L+ Y FR A N V I S+ +E Y + P +P I T +
Sbjct: 23328 KTTGLEEGVEYEFRVSAENIVGIGKPSKVSECY--VARDPCDPPG--RPEAIIVTRNSVT 23383
Query: 1499 IELT--CIFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXY--KC 1550
++ GG K+T Y KK + KA++ N Y +
Sbjct: 23384 LQWKKPTYDGG---SKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRV 23440
Query: 1551 IAFNDHGEV-ETSCVVG-IQQKPVITISNEDIKQKHK------VGDEWLVTAVIEGIPPP 1602
IA N G E S G I + + + K+K G+ + V A I G P P
Sbjct: 23441 IARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP 23500
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ W K +L N I + + + + +K+ R S Y ++A N AG SV V +KV
Sbjct: 23501 TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKV 23560
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
D+P PEGPV++ ++ E T+ WKPPL DGG ++ Y +E+ E W V D +
Sbjct: 23561 LDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVW-TVVDANVQ 23619
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+ + KL E EY FR++A N G E LESEP+V K VP + +
Sbjct: 23620 TLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPD-APKAPEVTTVTKD 23678
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXARIQKLSI--NTTYQFRI 1839
S+ + W +GGS I+ Y +E + +EG +W R++ + N Y+FR+
Sbjct: 23679 SMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRV 23738
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N G S P + P P N V + T SV L W++P +GG I
Sbjct: 23739 SAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQG 23798
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHC-IENIKEKDEIIFRISAENTVGV 1948
YI+E V WT G + +E + EK E FRI A N GV
Sbjct: 23799 YIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGV 23848
Score = 230 bits (563), Expect = 4e-59
Identities = 170/673 (25%), Positives = 288/673 (42%), Gaps = 33/673 (4%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
++ G + + ++ P P W + ++ L+I + DAG Y
Sbjct: 24963 VRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNY--TQLSIDNCDRNDAGKY 25020
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE 1418
L+LEN+ G + V +LD P PP + E+ S + W+ P G + + YV++
Sbjct: 25021 ILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID 25080
Query: 1419 YQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKET 1477
+E + +V + +KT ++NL + Y FR A NE + ET + K +
Sbjct: 25081 KRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPP 25140
Query: 1478 ----KIQSPTVEKPLKNITTEPNEDIELTCIFGGVP--QPKVTWYRDGKKLKTAKATYEN 1531
K+ V + ++ E E + + G V QPK T K A++ N
Sbjct: 25141 SPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGT----EKWSIVAESKVCN 25196
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-----KV 1586
++ A+N+ G+ + V+G+ +K +
Sbjct: 25197 ---AVVTGLSSGQEYQFRVKAYNEKGKSDPR-VLGVPVIAKDLTIQPSLKLPFNTYSIQA 25252
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G++ + + G P P + W K+G L+ N+ ++V+ IKE + KYT+
Sbjct: 25253 GEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVT 25312
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKH 1706
A+N+AGT++ +++ V +KP P GPV E+S + V I W+PP GG +++ Y +EK
Sbjct: 25313 ATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKR 25372
Query: 1707 EPDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALD 1765
+ W V A V R T I KL EY FR+ A+N G S L+S+ ++++
Sbjct: 25373 DTTTTTWHMVSATVAR--TTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFK 25430
Query: 1766 VPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXA 1824
P I + + + W +GG+ II Y +E K++ W
Sbjct: 25431 EPG-PPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDT 25489
Query: 1825 RIQKLSIN--TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSV 1882
+ + ++ Y+F++ A N +G P + PP +P V+ T +V
Sbjct: 25490 KFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVI---TRNNV 25546
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TLKW +P +GGS IT YI+E K + W K E + + E FR+ A
Sbjct: 25547 TLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIA 25606
Query: 1943 ENTVG-VSLPTES 1954
N G S P++S
Sbjct: 25607 RNAAGNFSEPSDS 25619
Score = 229 bits (561), Expect = 6e-59
Identities = 207/857 (24%), Positives = 348/857 (40%), Gaps = 45/857 (5%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVV 1284
VTW+K IE + + +L +R T D + YT +A + K +KV+V
Sbjct: 28917 VTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQ 28976
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
+ P K+V R I G +TL D P +I+ + + ++
Sbjct: 28977 DTPGKVVGPIRFTNIT-GEKMTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 29035
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCG-----HADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
S T K+ N + +++ N G +D + P PG P I +SI
Sbjct: 29036 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 29095
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKTQTSIQNLKTNSSYRFRAY 1454
+ W PE+ G S I Y++E +E +T W+ V + I++T+ + L + Y F
Sbjct: 29096 TLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVM 29155
Query: 1455 AVNEVDISDASETTEYYKVIKETKIQSP-TVEKPLKNITTEPNEDIELTCIFGGVP---- 1509
A N + AS + K + P TV K T + + GG+
Sbjct: 29156 AENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGY 29215
Query: 1510 --QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVG- 1566
+ D K+ A+A + R ++ A N G+ ++ V G
Sbjct: 29216 IIEMCKADLGDWHKVN-AEACVKTRYTVTDLQAGEEYK--FRVSAINGAGKGDSCEVTGT 29272
Query: 1567 IQQKPVITISNEDI----KQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
I+ +T DI KQ H V G + +G P P +W K + L +
Sbjct: 29273 IKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLS--LRAD 29330
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
I T + S + ++ R+ + KYT+ N +G+ S+ T+KV D P P GP+ ++++R
Sbjct: 29331 IHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPP-GPITFKDVTR 29389
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S T+ W PL DGG + Y +EK E W +V + + + L E Y FR
Sbjct: 29390 GSATLMWDAPLLDGGARIHHYVVEKREASRRSW-QVISEKCTRQIFKVNDLAEGVPYYFR 29448
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
V A N G E E ++ T P S + W + +GGS I
Sbjct: 29449 VSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDT---SKSSAVLAWLKPDHDGGSRIT 29505
Query: 1801 DYKVEIKQEGKK-WKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
Y +E++Q+G W +++L T Y+FR+ A+N+ G S P + + I
Sbjct: 29506 GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVII 29565
Query: 1860 GKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTV 1918
+ P+ + ++ + +T G P + + ++ K ++ +T
Sbjct: 29566 KEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITT 29625
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMV 1978
+++ D + ++ ENT GV T S +V + P P T P+E+ V
Sbjct: 29626 TKDRTTLTVKDSMRGDSGRYFLTLENTAGVK--TFSVTVVVIGR---PGPVTGPIEVSSV 29680
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
+ + SWG P+ GG + Y + R+ T W V V + + L++ Y
Sbjct: 29681 SAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNS-SVKRTQIKVTHLTKYMEYS 29739
Query: 2039 IRIYARNEIGLSEPLES 2055
R+ + N G+S+PLES
Sbjct: 29740 FRVSSENRFGVSKPLES 29756
Score = 229 bits (559), Expect = 1e-58
Identities = 268/1206 (22%), Positives = 488/1206 (40%), Gaps = 88/1206 (7%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
+P F ++ +P V +V G P +ITWF+ I++ + ++ + D++ +L
Sbjct: 5319 SPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFI-QDHLVSL 5377
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I + DAG + C N G + + + + P S ++ A +
Sbjct: 5378 QILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPS-FIKKIESTSSLRGGTAAFQATL 5436
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLF-KGEEIVPDENISVAIESD 687
+P T + + + E +I + E ++A L+ G E+ D ++D
Sbjct: 5437 KGSLPITVTWLKDSDEITEDDNIRMTF------ENNVASLYLSGIEVKHDGKYVCQAKND 5490
Query: 688 MHMY-CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK-TGEKEPPQVIEPLKSMI 745
+ CS L +VK + T T AV+ + P L++K +G KE + +
Sbjct: 5491 AGIQRCSAL--LSVK--EPATITEEAVSIDVTQGDPATLQVKFSGTKE-------ITAKW 5539
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+ G+ + L ++ + T++ K I+ +K KD G YT
Sbjct: 5540 FKDGQELTLGSKYKISVTDTVSILK--------------------IISTEK-KDSGEYTF 5578
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+ +N G + A I V + PP F + +++ + I L V + SI
Sbjct: 5579 EVQNDVGRSSCKARINV----LDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQ 5634
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W+++++ IS SE +F L I+ ++ DSG Y C A+N AG + +T+
Sbjct: 5635 WFKDDQEISASEKYKFSFHDNTAFLEISQLEG-TDSGTYTCSATNKAGHNQCSGHLTVK- 5692
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXX 983
E FV+ Q S + V L+ T ++ KW+ + KE+ R + ++
Sbjct: 5693 EPPYFVEKPQ-SQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTS 5751
Query: 984 XXXXXXXXXDVGVIKC-IVKDQETST---MLVVKETIPEFIRKLQDFEV-KEKDVAILEV 1038
D G C + D T+T L VKE P+FI+K V + E
Sbjct: 5752 LELFAAKATDSGTYICQLSNDVGTATSKATLFVKEP-PQFIKKPSPVLVLRNGQSTTFEC 5810
Query: 1039 EI-NSETADVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
+I + V W DG EI +K+ F + I V + G Y C R+++
Sbjct: 5811 QITGTPKIRVSWYLDGNEITAIQKHGISF--IDGLATFQISGARVENSGTYVCEARNDAG 5868
Query: 1097 TAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHI 1152
TA ++ V+ PP I L+ +V K + E E+T V W K+ EI+ S
Sbjct: 5869 TASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKY 5928
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFILV 1208
LT L I CD D GEY C E G+ C+ + ++EP +F ++ V
Sbjct: 5929 TLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPP-SFIKKIENTTTV 5987
Query: 1209 PANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC 1268
++ + + + +TW K ++++ + + TL IR YTC
Sbjct: 5988 LKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTC 6047
Query: 1269 VLLDAKSTTK-LKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
+ + +V+ P +IV+ + + +TL P+ +W+ + K
Sbjct: 6048 QAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQ 6107
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG-K 1386
I ++ S ++ AS I+ V D+G Y ++EN+ G + + + +LD+ PP
Sbjct: 6108 IVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFT 6167
Query: 1387 PNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTT-EWISVKNITKTQTSIQNLK 1444
+ ++D + E + +G+ I + + +EI T+ ++ V + + NL+
Sbjct: 6168 KKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLE 6227
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI 1504
+ + V+ V DA I K + KP + P+ +E I
Sbjct: 6228 LEDTANYTC-KVSNVAGDDACSG------ILTVKEPPSFLVKPGRQ-QAIPDSTVEFKAI 6279
Query: 1505 FGGVPQPKVTWYRDGKKLKTAKATY----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
G P K+ W++D +L + + + Y C ND G
Sbjct: 6280 LKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDS 6339
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
+ ++ + + P + + + K GD + I G P V+W++N ++L +Y
Sbjct: 6340 CTTMLLVTEPPKF-VKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYR 6398
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
+T + +VI++ L S + EA N AG++S + V + P P I+ +
Sbjct: 6399 MTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKN 6458
Query: 1681 ESVTIE 1686
V++E
Sbjct: 6459 AEVSLE 6464
Score = 227 bits (554), Expect = 4e-58
Identities = 206/781 (26%), Positives = 325/781 (41%), Gaps = 48/781 (6%)
Query: 1207 LVPANTDAYLTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
LV A + VEIP VTW K +++ T++ + L I +C D
Sbjct: 22001 LVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDS 22060
Query: 1264 CEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
Y L A++ +V+ + IK + V + P ND +
Sbjct: 22061 GPYP---LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 22117
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIK---KVENTDAGI---YKLRLENNCGHADVEMNVTI 1377
S + + + T + + A+ I+ K G+ ++++ +N G + I
Sbjct: 22118 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 22177
Query: 1378 LDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN 1432
+ P PPG P + + S+ I W EP + G S I+ Y VE +E + W +V
Sbjct: 22178 VANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSK 22237
Query: 1433 ITKTQTSIQN--LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN 1490
++ L +Y FR A N S S+ +E ++ I P PL N
Sbjct: 22238 ALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSE--PMLALDPIDPPGKPVPL-N 22294
Query: 1491 ITTEP-NEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXXXXXXXXXXXXX 1545
IT GG K+T Y RD + KA + N
Sbjct: 22295 ITRHTVTLKWAKPEYTGGF---KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTED 22351
Query: 1546 XXY--KCIAFNDHGEV----ETSCVVGIQQKPVITISNEDIKQKH----KVGDEWLVTAV 1595
Y + IA N G + E S + + D+K K K G+ + + A
Sbjct: 22352 AAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEAD 22411
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ G PPP + W K+G +LE + I + ++ + K+ R S YT+ A+N G +
Sbjct: 22412 VSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAK 22471
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
+KV D+P PEGP+ + E++ E + W PPLDDGG ++ Y ++K E W
Sbjct: 22472 HIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTN 22531
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXX 1775
VA + V + KL + EY+FRV+A N G E LESEP++ P
Sbjct: 22532 VAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYG-PPDPPKNPE 22589
Query: 1776 XXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQE-GKKWKXXXXXXXXXAR--IQKLSIN 1832
I +S+ + W + +GGS II+Y VE + + G++W R + L+
Sbjct: 22590 VTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEG 22649
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESN 1892
Y+FRI A N G S P + T+ P P N V +++ S+++ W +P +
Sbjct: 22650 HEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYD 22709
Query: 1893 GGSPITNYIIEFKTVKGKSWTKIVT--VGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
GGS IT Y++E + W +IVT G + I + E E RI A N+ G+
Sbjct: 22710 GGSEITGYMVEIALPEEDEW-QIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 22768
Query: 1951 P 1951
P
Sbjct: 22769 P 22769
Score = 225 bits (550), Expect = 1e-57
Identities = 249/1194 (20%), Positives = 467/1194 (39%), Gaps = 94/1194 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++L P + V ECQV+ + +TW + + P +D+++ + +D +ATL
Sbjct: 4571 PHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICF-EDKIATLE 4629
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
I +D+GT+ C A N AG +S + + V P S +
Sbjct: 4630 IPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPS----------------------FV 4667
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+ + P++ P G L C+L P + W +E+ + + +
Sbjct: 4668 KKVDPSYLMLP-------GESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSE- 4719
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
++L IT+VK G+Y+ AVN G S + I KEPP I+ L+ + +G
Sbjct: 4720 ---AILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVI----KEPPSFIKTLEPADIVRG 4772
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK--PKKVKDEGVYTLKA 807
+ +L +V G I+W K+ K +++ S+ L+ D G Y
Sbjct: 4773 TNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVV 4832
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
N G A T EPP F+ + ++ T+ L A V + S+TW
Sbjct: 4833 ANEVGKCGCMA-------THLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWM 4885
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ E+I I +F L+I +V G Y C+A N AG + + + E
Sbjct: 4886 KGQEVIREDGKIKMSFSNGVAVLIIPDVQISF-GGKYTCLAENEAGSQTSVGELIVK-EP 4943
Query: 928 VTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
++ + + G LE + T + KWY + + + I +
Sbjct: 4944 AKIIERAE-LIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLK 5002
Query: 986 XXXXXXXDVGVIKCIVKDQ------ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVE 1039
D G + ++ ET+ ++ ++ P F + L++ + L+ +
Sbjct: 5003 FYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCK 5062
Query: 1040 I-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ES 1095
I S V W +DG+ I ++Y L I ++D G ++C +
Sbjct: 5063 IAGSLPMRVSWFKDGKEI-AASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSK 5121
Query: 1096 CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQL 1154
++ +V+ PP +T+ ++ V G+ + L +RWFK E+ +
Sbjct: 5122 DSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYI 5181
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPEFILVPA 1210
T + + L++Y D+G Y+C+V G +C+A L V+EP+ F +L L+
Sbjct: 5182 TKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPA-TFVEKLEPSQLLKK 5240
Query: 1211 NTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC- 1268
L ++ + +TW+ I+++ K + L + +D EY C
Sbjct: 5241 GDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCE 5300
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
+A S + +V+ P + + + DV LL + P W ++ I+
Sbjct: 5301 AQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTIL 5360
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN 1388
+ + K I SL I K DAG Y+ R+ N G + VT+ + PS
Sbjct: 5361 RSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPS-----F 5415
Query: 1389 ILEIDS-SSINICWDEPENTGNSTIIYYVVEYQEID-TTEWISVKNITKTQTS---IQNL 1443
I +I+S SS+ + T ++ V ++ D TE +++ + + + +
Sbjct: 5416 IKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGI 5475
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTC 1503
+ ++ A N+ I S +KE T+ + +I + L
Sbjct: 5476 EVKHDGKYVCQAKNDAGIQRCSALLS----VKE----PATITEEAVSIDVTQGDPATLQV 5527
Query: 1504 IFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
F G + W++DG++L K + + Y ND G
Sbjct: 5528 KFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRS 5587
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + + + +K+ + ++ + ++ G P + W+K+ ++ ++
Sbjct: 5588 SCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEK 5647
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
Y + + T+ + I +L+ + S YT A+N AG + L V + P E P
Sbjct: 5648 YKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKP 5701
Score = 224 bits (548), Expect = 2e-57
Identities = 224/984 (22%), Positives = 400/984 (40%), Gaps = 67/984 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P T +KP++ V G LEC + PE W G+E+ D ++ + +
Sbjct: 8512 PATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKV---- 8567
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
S LKI NV G Y+ N G+ S L++ + PP LK G SV
Sbjct: 8568 SGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQV-SDRTVPPSFTRKLKETNGLSGSSV 8626
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
++ +V G+P +++W + + T +T ++T+ ++ D G YT A N
Sbjct: 8627 VMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEE-SDSGDYTCIATN 8685
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G E SA +TV EP P F+ + + V + + V P S++W++
Sbjct: 8686 MAGSDECSAPLTVREP-------PSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKG 8738
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + P + + + EL + +VD+ SG+Y C+ SN AGK+S + I
Sbjct: 8739 SSELVPGDRCNVSLEDSVAELELFDVDTS-QSGEYTCIVSNEAGKASCTTHLYIKAP-AK 8796
Query: 930 FVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
FVK L Y E+GK +ILE + T +S W N ++ I +
Sbjct: 8797 FVKRLN-DYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIP 8855
Query: 988 XXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI-NS 1042
D G C +++ S +++ E P F+++L+ +V D A L+ ++ +
Sbjct: 8856 SSTVEDAGQYNCYIENASGKDSCSAQILILEP-PYFVKQLEPVKVSVGDSASLQCQLAGT 8914
Query: 1043 ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----SCTA 1098
V W + ++P Y R ++ L ++D GEY C + S +
Sbjct: 8915 PEIGVSWYKGDTKLRPTTT-YKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSAST 8973
Query: 1099 EVTVVE--LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLT 1155
+TV E LPP +L++ + G F+ ++ + + V W+KDG ++ S ++Q +
Sbjct: 8974 FLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTS 9033
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGN------SKCTAILTVEEPSINFTLRLPEFILVP 1209
L I+ D AG+YSC N S ILT + F +RL V
Sbjct: 9034 FLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV 9093
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ + + + V+W K I K+ + L + K + D +YTC
Sbjct: 9094 GESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCY 9153
Query: 1270 LLDA----KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQP-NDEWIVN 1324
++ T +L ++ PP E + + L A QP W N
Sbjct: 9154 AVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKN 9213
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+ I+ + + + + + L ++K DAG+Y ++ N+ G A ++ I + PP
Sbjct: 9214 NIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPP 9273
Query: 1385 G-KPNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
++ + S G+ I I ++ +EI ++ S + T++
Sbjct: 9274 VFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFS--FASGTAVLE 9331
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN----ITTEPN-- 1496
L+ + Y +++ S+TT+ IK+ +P +K + +EP
Sbjct: 9332 LRDVAKADSGDYVCKASNVA-GSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSI 9390
Query: 1497 ---EDIELTCI--FGGVPQPKVTWYRDG-KKLKTAKATYENRXXXXXXX----XXXXXXX 1546
E T I GG P P V W + ++L + ++
Sbjct: 9391 RVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSG 9450
Query: 1547 XYKCIAFNDHGEVETSCVVGIQQK 1570
Y+C+AFN+HGE+E++ + + ++
Sbjct: 9451 LYRCVAFNEHGEIESNVNLQVDER 9474
Score = 224 bits (547), Expect = 3e-57
Identities = 238/963 (24%), Positives = 395/963 (41%), Gaps = 77/963 (7%)
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL 1200
+D E+QF+ ++ ++G + + ++ + + S VG C + P + ++
Sbjct: 16996 RDVEELQFT--VEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDC------QRPDMPPSI 17047
Query: 1201 RLPEFILVPANTDAYLTVEIPDETLD-VTWYK--------KKSVIEDTEKFTLISDVKKR 1251
L EF+ V T+ + +I +TW+K K+ V+ DT L+ D
Sbjct: 17048 DLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD-DTC 17106
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
TL+I + D YT ++ T ++++ V+ P V ++ +TL
Sbjct: 17107 TLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVG-PIKFESVSADQMTL-- 17163
Query: 1310 DYQAFPQPND--EWIVNSKIIKKCKHTKP----SIDSKSASLTIKKVENTDAGIYKLRLE 1363
FP +D I N I K+ + K S + K + TI K+ ++++ +
Sbjct: 17164 --SWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQ 17221
Query: 1364 NNCG-----HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE 1418
N G ++ E + P P KP + + +S+ + W+EPE G S + Y +E
Sbjct: 17222 NKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLE 17281
Query: 1419 YQEIDTTEWISV-KNITKTQT-----SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
++ + W V ++ K T + L S Y+FR YA+N + AS ++
Sbjct: 17282 MKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSD--P 17339
Query: 1473 VIKETKIQSPTVEKPLKNITTEPNEDIELTCIF---GGVPQPKVTWYRDGKKLKTAKATY 1529
I P P T+ + D+E + G + Y++ K + K
Sbjct: 17340 ATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKD 17399
Query: 1530 ENRXXXXXXXXXXXXXXXYK----CIAFNDHGEV-ETSCVVGIQQKPVITISNEDIKQKH 1584
+ YK + GE E + V+ ++ + V D +
Sbjct: 17400 KEVRGTKLVVTGLKEGAFYKFRVSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRD 17459
Query: 1585 KV----GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHS 1640
++ G + A + G PPP V W N L +E I T +S + IK +RSH
Sbjct: 17460 RIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLP--QEATIETTAISSSMVIKNCQRSHQ 17517
Query: 1641 SKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTK 1700
Y++ A N AG + + V D P P + ++ ES + W P DDGG +T
Sbjct: 17518 GVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITN 17577
Query: 1701 YAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPI 1758
Y IEK E D W V V R T +Q L + Y FR+ A+N +G +E SE +
Sbjct: 17578 YVIEKRESDRRAWTPVTYTVTRQNAT--VQGLIQGKAYFFRIAAENSIGMGPFVETSEAL 17635
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXX 1818
VI+ + VP N +V +TW P + +GGS II+Y +E + G +
Sbjct: 17636 VIREPITVPERPEDLEVKEVTKN-TVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVT 17694
Query: 1819 XXXXXAR---IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVS 1875
+R ++ L TY++R+ A N +G P IT L PP+ +F
Sbjct: 17695 NDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDK 17754
Query: 1876 ESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEK-- 1933
+ T S P ++ + V T I T ++ +E IK K
Sbjct: 17755 LTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATL---ALEKIKAKRS 17811
Query: 1934 DEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
D + + EN+ G S Q +++ P PP P+ V + ++ SW P D
Sbjct: 17812 DSGKYCVVVENSTG-SRKGFCQVNVVDR----PGPPVGPVSFDEVTKDYMVISWKPPLDD 17866
Query: 1994 GGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
GG+ + Y I ++V K +WM V T + L E Y+ RI+A N G+S+PL
Sbjct: 17867 GGSKITNYIIEKKEVGKDVWMPVTSASAKT-TCKVSKLLEGKDYIFRIHAENLYGISDPL 17925
Query: 2054 ESD 2056
SD
Sbjct: 17926 VSD 17928
Score = 223 bits (545), Expect = 5e-57
Identities = 192/796 (24%), Positives = 337/796 (42%), Gaps = 44/796 (5%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSV-IEDTEKFTLISDVK 1249
+E P I+ + V A ++ + + I + L + V ++ T +F +
Sbjct: 27398 LEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAE 27457
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
T+ +++ D Y ++ TTK + +V + I ++ ++ +
Sbjct: 27458 NLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLD-RPGPPTGPVVISDITEESVTL 27516
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSID-SKSASLTIKKVENTDAGI---YKLRLENN 1365
++ + N ++K+ T + S + + T+ KV G ++++ EN
Sbjct: 27517 KWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENR 27576
Query: 1366 CGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
G +D + + K P PP P + + SI + W EP + G S ++ Y +E +
Sbjct: 27577 FGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMK 27636
Query: 1421 EIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK 1478
+ ++ W I T + + Y FR YA N + S +E V+
Sbjct: 27637 DRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSE--PVLAIDA 27694
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXX 1534
+ P + + + GG K+T Y RD + KA++ N
Sbjct: 27695 CEPPRNVRITDISKNSVSLSWQQPAFDGG---SKITGYIVERRDLPDGRWTKASFTNVTE 27751
Query: 1535 XXXXXXXXXXXXXYKCIAF--NDHGEVET-SCVVG------IQQKPVITISNEDIKQ-KH 1584
Y+ F N G + S VVG PVI + E + K+
Sbjct: 27752 TQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKY 27811
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+ G + A I G P P + WYK+ +L+ + + + I IK+ R +S Y
Sbjct: 27812 RAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYE 27871
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
++ N G++S + +++ DKP P GP+ + ++ E +T+ W+PP DDGG ++T Y +E
Sbjct: 27872 LKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVE 27931
Query: 1705 KHEPDNNRWIKVAD-VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTA 1763
K E W V++ ++ + T K+ + EY+FRV A N G E LES+ +V K A
Sbjct: 27932 KRETSRVVWSMVSEHLEECIIT--TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNA 27989
Query: 1764 LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK--WKXXXXXXX 1821
P I S+ + W +GGS I Y +E K++ K W
Sbjct: 27990 FVTPG-PPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLE-KRDKKSLGWFKVLKETI 28047
Query: 1822 XXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKI-TIGKTLTPPSQPRNFVVSEST 1878
R + L+ N+ YQ+R+ A N G P++ + + PP P +++ST
Sbjct: 28048 RDTRQKVTGLTENSDYQYRVCAVNAAGQG-PFSEPSEFYKAADPIDPPGPPAKIRIADST 28106
Query: 1879 SRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG-SVHEHCIENIKEKDEII 1937
S+TL W++P +GGS +T Y++E + + + WT + T G E+ + N+K
Sbjct: 28107 KSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYY 28166
Query: 1938 FRISAENTVGVSLPTE 1953
FR+SA N G P E
Sbjct: 28167 FRVSAVNCAGQGEPIE 28182
Score = 221 bits (540), Expect = 2e-56
Identities = 185/703 (26%), Positives = 304/703 (43%), Gaps = 40/703 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV----KNITK 1435
KPSPP P ++ +S+++ W P + G S I+ Y+VEYQ++ EW ++ +
Sbjct: 18039 KPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPE 18098
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
T+ + L+ +Y+FR AVN SD + E V+ + +++ P + N+ E
Sbjct: 18099 TKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE--PVLVKDRLEPPELILDA-NMAREQ 18155
Query: 1496 N----EDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXXXXY 1548
+ + + L+ I GVP PKVTW ++ + T KA + Y
Sbjct: 18156 HIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPT-KARIDVTPVGSKLEIRNAAHEDGGIY 18214
Query: 1549 KCIAFNDHGEVETSCVVGIQQKPVITISNEDIK-QKHKVGDEWLVTAVIEGIPPPEVIWY 1607
N G S V + KP E + +K W G +
Sbjct: 18215 SLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVE 18274
Query: 1608 KNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT---LKVYD 1664
+ + T+K+K+ K L + + + A N G T +K D
Sbjct: 18275 RRDVASAQWSPLSATSKKKSHFA--KHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALD 18332
Query: 1665 KPSKPEGP---VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
P P GP + ++ + V++ W P DGG +T Y +E E WIK V
Sbjct: 18333 -PLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVT- 18390
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDN 1781
++E + L + Y FRV A+N VG + PI + L PS +
Sbjct: 18391 NLECV-VTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVV 18449
Query: 1782 ESVYITWFPSEKNGGS-PIIDYKV---EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQF 1837
++ FP+ G P + EIK + + + I+ T ++
Sbjct: 18450 KAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSVLTIKNCLRRDTGEY 18508
Query: 1838 RIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPI 1897
+I N G+ T +T+ PP+ P N + + T +T+ W P+ +GGSP+
Sbjct: 18509 QITVSNAAGSK---TVAVHLTVLDVPGPPTGPINIL--DVTPEHMTISWQPPKDDGGSPV 18563
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
NYI+E + + +W +V+ G S + I ++++ E +FR+ AEN +GV P +S
Sbjct: 18564 INYIVEKQDTRKDTWG-VVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPT 18622
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
+ + PSPP P+ + + N SW P+ DGG+P+ GY + R+VT W+ V
Sbjct: 18623 VAKHKFSPPSPPGKPV-VTDITENAATVSWTLPKSDGGSPITGYYMERREVTGK-WVRVN 18680
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
K + LKF + L E +TY R++A N GLS+P S +P K
Sbjct: 18681 KTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIK 18723
Score = 220 bits (538), Expect = 4e-56
Identities = 238/1072 (22%), Positives = 437/1072 (40%), Gaps = 75/1072 (6%)
Query: 633 PPTFSKKPK-AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA-IESDMHM 690
P TF +K + +Q + +G L C++ P I W EI ++ +ES
Sbjct: 5225 PATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVES---- 5280
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+VL++T+V G Y A N G ++ + KE P + K + V +
Sbjct: 5281 -TAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIV----KESPYFTKEFKPIEVLKEY 5335
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKA-LPTKSDGDTHSITILKPKKV-KDEGVYTLKAE 808
V+L A+V G P ITW K+N +++ K+ H +++ K V D G Y +
Sbjct: 5336 DVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVT 5395
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
N G + SA +T+ EPP FI + + + GT A + + ++TW +
Sbjct: 5396 NEVGSSICSARVTLR-------EPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLK 5448
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
+++ I+ + I F+ L ++ ++ + D G Y C A N AG A +++ E
Sbjct: 5449 DSDEITEDDNIRMTFENNVASLYLSGIEVKHD-GKYVCQAKNDAGIQRCSALLSVK-EPA 5506
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEIS-GMDHR----------EI 975
T + S + +G L+ + S T ++ KW+ + +E++ G ++ +I
Sbjct: 5507 TITEE-AVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKI 5565
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFE-VKEKDVA 1034
I + DVG C K + L++ P F +KL+ + +K +
Sbjct: 5566 ISTEKKDSGEYTFEVQNDVGRSSC--KARINVLDLIIP---PSFTKKLKKMDSIKGSFID 5620
Query: 1035 ILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
+ + S + W +D + I + KY F + L I D G Y+C ++
Sbjct: 5621 LECIVAGSHPISIQWFKDDQEISASE-KYKFSFHDNTAFLEISQLEGTDSGTYTCSATNK 5679
Query: 1095 S----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA--LVRWFKDGSEIQF 1148
+ C+ +TV E PP + + Q+Q VN + + L G A ++WFKD E+
Sbjct: 5680 AGHNQCSGHLTVKE-PPYFVEKPQSQDVNPNTRVQLK-ALVGGTAPMTIKWFKDNKELHS 5737
Query: 1149 SNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
+ D L+++ D+G Y C +VG + A L V+EP P
Sbjct: 5738 GAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPV 5797
Query: 1205 FILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQC 1264
+L + + + V+WY + I +K + T I ++
Sbjct: 5798 LVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSG 5857
Query: 1265 EYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
Y C + T +E+ V+ PP + + + + SDV L + P W+
Sbjct: 5858 TYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK 5917
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
N++ I+ K + +L I K + +D G Y+ + N G V + + PS
Sbjct: 5918 NNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSF 5977
Query: 1384 PGK-PNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQT-SI 1440
K N + SS + G+ I I ++ + Q +D + + + + T I
Sbjct: 5978 IKKIENTTTVLKSSATF---QSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQI 6034
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+++ S R+ A NE + E + +++E + VEK K++ + +
Sbjct: 6035 RSVDNGHSGRYTCQAKNESGV----ERCYAFLLVQE---PAQIVEK-AKSVDVTEKDPMT 6086
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAK---ATYENR-XXXXXXXXXXXXXXXYKCIAFNDH 1556
L C+ G P+ KV W +DGK++ ++ ++EN Y ND
Sbjct: 6087 LECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDF 6146
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G + + + + + + + KV G + + G P W+K+G ++
Sbjct: 6147 GSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEIST 6206
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+Y + E++ + + L+ ++ YT + SN AG + L V + PS
Sbjct: 6207 SAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPS 6258
Score = 220 bits (537), Expect = 5e-56
Identities = 207/803 (25%), Positives = 340/803 (42%), Gaps = 53/803 (6%)
Query: 1202 LPEFI-LVPANTDAYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
LP+ L N++ L + I + V+W K + + + ++ S TLI+ C
Sbjct: 20914 LPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQ 20973
Query: 1260 EDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
+ D +YT L + T + + + V P I ++ +TL A P+ +
Sbjct: 20974 KSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLK---WAPPKDD 21030
Query: 1319 DEWIVNSKIIKK--CKHTKPSIDSKSASLTIKKVENTDAGI---YKLRLENNCGHADVEM 1373
+ + I++K + K + + T +V G+ +++ EN G +
Sbjct: 21031 GGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLK 21090
Query: 1374 NVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWI 1428
+ I+ D P P PNI+++ S+++ W +P+ TG S I Y +E++E ++ W
Sbjct: 21091 SEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLW- 21149
Query: 1429 SVKNITKTQTSIQNLKTNS-----SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT 1483
K KT +++ K Y FR A+N + S +E V+ I P
Sbjct: 21150 --KRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSE--PVVALDPIDPPG 21205
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXXXXXXX 1539
+ + NIT I + G K+T Y RD KA + N
Sbjct: 21206 KPEVI-NITRNSVTLIWTEPKYDG--GHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTV 21262
Query: 1540 XXXXXXXXY--KCIAFNDHGEV-------ETSCVVGIQQKPVITISNEDIKQ--KHKVGD 1588
Y + A N G + ET + P I + + IK K GD
Sbjct: 21263 TDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVL-DPTIKDGLTIKAGD 21321
Query: 1589 EWLVTAV-IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
++ A+ I G P P+ W K G + IT+ +S++ IK R + +YTI A
Sbjct: 21322 TIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITA 21381
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
+N GT V + V D P P GPV + +S E T+ W PPL+DGG + Y +EK E
Sbjct: 21382 TNPFGTKVEHVKVTVLDVPGPP-GPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRE 21440
Query: 1708 PDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP 1767
W V++ D + KL + EY+FRV A N G E ++SEP+ + P
Sbjct: 21441 TSRLLWTVVSE-DIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPP 21499
Query: 1768 SXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXXXXXXXXAR- 1825
N + ++W +GGS I Y VE ++ + +W R
Sbjct: 21500 GPPEKPEVSNVTKNTAT-VSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRC 21558
Query: 1826 -IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTL 1884
+ L +TY+FR+ A N G P + D + + PP P N V+++T +S +L
Sbjct: 21559 KVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASL 21618
Query: 1885 KWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT-VGGSVHEHCIENIKEKDEIIFRISAE 1943
W +P +GG IT Y++E + V ++W K T + + + +++ K++ FRISA
Sbjct: 21619 AWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAI 21678
Query: 1944 NTVGVSLPTESQSVRLEKHATVP 1966
N GV P V + + P
Sbjct: 21679 NDAGVGEPAVIPDVEIVEREMAP 21701
Score = 219 bits (534), Expect = 1e-55
Identities = 226/1068 (21%), Positives = 428/1068 (40%), Gaps = 58/1068 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F KKP +G+D+ LEC L P ++W E+ + + E+ +
Sbjct: 8325 PPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSEN----FL 8380
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ + I NV G Y A N G + + +K PP+ ++ L + G+ V
Sbjct: 8381 TSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKA----PPRFVKKLSDISTVVGKEV 8436
Query: 753 ILSAQVVGNPRPTITWCKNN-KPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAEN 809
L + G ++ W K+ + V+ + +I L+ +V+ + G YT + +N
Sbjct: 8437 QLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKN 8496
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ E A ++V EP + + + I V T L V P S W+++
Sbjct: 8497 DAGMQECFATLSV-------LEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKD 8549
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV- 928
+ ++ +F + L I NV + DSG Y N GK S A + + V
Sbjct: 8550 GKELTSDNKYKISFFNKVSGLKIINV-APSDSGVYSFEVQNPVGKDSCTASLQVSDRTVP 8608
Query: 929 -TFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
+F + L+++ G +V++EC+ S +S W+H EIS +
Sbjct: 8609 PSFTRKLKETNGLS-GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALT 8667
Query: 986 XXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEI 1040
D G CI + E S L V+E P F++K +V +V +
Sbjct: 8668 VNMLEESDSGDYTCIATNMAGSDECSAPLTVREP-PSFVQKPDPMDVLTGTNVTFTSIVK 8726
Query: 1041 NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
+ V W + + P ++ + + +L + + GEY+CI+ +E+ A
Sbjct: 8727 GTPPFSVSWFKGSSELVPG-DRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASC 8785
Query: 1101 TV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTI 1156
T ++ P + + RL + + KG E T + V W K+G + S +T
Sbjct: 8786 TTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITT 8845
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPEFILVPANT 1212
K L+I ++DAG+Y+C + G C+A + + EP F +L E + V
Sbjct: 8846 TEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPY-FVKQL-EPVKVSVGD 8903
Query: 1213 DAYLTVEIPDET-LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV-- 1269
A L ++ + V+WYK + + T + + TL+ + +D EY C
Sbjct: 8904 SASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAE 8963
Query: 1270 --LLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
+ + ++T L V+ + PP R+ + G V + W + K
Sbjct: 8964 NSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKP 9023
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKP 1387
+K + + S +A+L I K + + AG Y N G A + + + +PP
Sbjct: 9024 LKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFD 9083
Query: 1388 -NILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKT-QTSIQNLK 1444
+ +D+ E TG I + + + +EI + + + + ++ +
Sbjct: 9084 IRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVD 9143
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI 1504
S ++ YAVNEV + IKE I ++ + + +L
Sbjct: 9144 KGDSGQYTCYAVNEVGKDSCTAQLN----IKERLIPPSFTKRLSETVEETEGNSFKLEGR 9199
Query: 1505 FGGVPQPKVTWYRDGKKLK---TAKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVE 1560
G V WY++ +++ + T++N Y C ND G
Sbjct: 9200 VAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSAL 9259
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
+ + I++ + ++ + E++ ++ ++G P + W K G +++
Sbjct: 9260 CTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRC 9319
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + T+V+ ++++ ++ S Y +ASN AG+ + + + + DKP+
Sbjct: 9320 SFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPA 9367
Score = 218 bits (533), Expect = 2e-55
Identities = 225/903 (24%), Positives = 364/903 (40%), Gaps = 84/903 (9%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
VEK G T EC V G P WF+ + +++ + + V+ L I
Sbjct: 8516 VEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFN-KVSGLKIIN 8574
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGI 632
V P D+G ++ +N G S T L V S+ TV
Sbjct: 8575 VAPSDSGVYSFEVQNPVGKDSCTASLQV--------SDRTV------------------- 8607
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F++K K GS +++EC++ P ++W +G EI + + C
Sbjct: 8608 PPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNT---C 8664
Query: 693 SVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ L + +++ G YT +A N G E S P+ + +EPP ++ M V G
Sbjct: 8665 A-LTVNMLEESDSGDYTCIATNMAGSDECSAPLTV------REPPSFVQKPDPMDVLTGT 8717
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAE 808
+V ++ V G P +++W K + + + S+ L+ V G YT
Sbjct: 8718 NVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVS 8777
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
N G A + + ++ P + F+ R + ++++ + L T P S+TW +
Sbjct: 8778 NEAGKASCTTHLYIKAPAK-------FVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKK 8830
Query: 869 NNEIISPSE--TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
N ++PS+ IT +E+ + V+ D+G Y C N++GK S A++ I +E
Sbjct: 8831 NGINVTPSQRCNITTTEKSAILEIPSSTVE---DAGQYNCYIENASGKDSCSAQILI-LE 8886
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXX 984
FVK L+ + G + L+CQ + T + WY ++ ++
Sbjct: 8887 PPYFVKQLE-PVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATL 8945
Query: 985 XXXXXXXXDVGVIKC----IVKDQETSTMLVVKE--TIPEFIRKLQDFEVKEKDVAILEV 1038
D G C V + ST L V+E P F R+L+D + + +
Sbjct: 8946 VFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDC 9005
Query: 1039 EIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI----LRD 1093
I+ SE V W +DG+ +K N + L I T G+YSC +
Sbjct: 9006 AISGSEPISVSWYKDGKPLKDSPN-VQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGS 9064
Query: 1094 ESCTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSN 1150
S +A + + E PP RL G A FE +T + V W KD EI+
Sbjct: 9065 ASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGG 9124
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI--NFTLRLPE 1204
Q++ L + D D+G+Y+C EVG CTA L ++E I +FT RL E
Sbjct: 9125 KYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSE 9184
Query: 1205 FILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
+ L + + + V WYK I+ T + L +RK +D
Sbjct: 9185 TVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDA 9244
Query: 1264 CEYTC-VLLDAKS---TTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPND 1319
YTC V DA S T+ + ++ + PP + + G V L Q
Sbjct: 9245 GLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRI 9304
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
+W+ + IK S S +A L ++ V D+G Y + N G + VTI D
Sbjct: 9305 QWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKD 9364
Query: 1380 KPS 1382
KP+
Sbjct: 9365 KPA 9367
Score = 217 bits (531), Expect = 3e-55
Identities = 198/748 (26%), Positives = 332/748 (44%), Gaps = 48/748 (6%)
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD--VEMNVTILDK---PSPPGKPNILE 1391
S +K+ K +E D I+++ EN G +D V ++ D+ P P +P + E
Sbjct: 17891 SASAKTTCKVSKLLEGKDY-IFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTE 17949
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNIT---KTQTSIQNLKTNSS 1448
+ S + W++P + G I Y++E +E + W V T+ + +L
Sbjct: 17950 VTKDSALVTWNKPHD-GGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQ 18008
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI---- 1504
Y FR A NE+ I D S ++ V + I P+ + I T N ++LT
Sbjct: 18009 YEFRVSAENEIGIGDPSPPSK--PVFAKDPIAKPSPPVNPEAIDTTCNS-VDLTWQPPRH 18065
Query: 1505 FGG--VPQPKVTWYRDG-KKLKTAKATYENRXXXXXXXXXXXXXXXYK--CIAFNDHGEV 1559
GG + V + + G ++ + A T E+ YK +A N GE
Sbjct: 18066 DGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGES 18125
Query: 1560 ETSCV---VGIQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
+ + V V ++ + P + + +++H KVGD ++A+I+G+P P+V W K
Sbjct: 18126 DPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRD 18185
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
++T S + I+ Y++ N AG+ +V V + V DKP P
Sbjct: 18186 APTKARIDVT--PVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPR-D 18242
Query: 1673 VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLN 1732
+ + EI ++S + WK PLDDGG +T Y +E+ + + +W ++ + +++ + LN
Sbjct: 18243 LEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKK-KSHFAKHLN 18301
Query: 1733 ENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV--PSXXXXXXXXXXIDNESVYITWFP 1790
E +Y+FRV A+N G +E+ P IK ALD P +D V + W
Sbjct: 18302 EGNQYLFRVAAENQYGRGPFVET-PKPIK-ALDPLHPPGPPKDLHHVDVDKTEVSLVWNK 18359
Query: 1791 SEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSL 1849
+++GGSPI Y VE ++EG + W + L TY+FR+ A N +G L
Sbjct: 18360 PDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGL 18419
Query: 1850 PYTSDDKITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESNGGSPITNYIIEFKTV 1907
P T+ I + L PPS + + E T+++ P + + +
Sbjct: 18420 PDTT-IPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI 18478
Query: 1908 KGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPS 1967
K + T S I+N +D ++I+ N G +++ +V L VP
Sbjct: 18479 KTDEHYTVETDNFS-SVLTIKNCLRRDTGEYQITVSNAAG----SKTVAVHLTV-LDVPG 18532
Query: 1968 PPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFN 2027
PPT P+ I V + SW P+ DGG+P++ Y + +D K W V T K
Sbjct: 18533 PPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT-KLK 18591
Query: 2028 IRDLSENHTYMIRIYARNEIGLSEPLES 2055
I L + Y+ R+ A N+IG+ PL+S
Sbjct: 18592 IPHLQKGCEYVFRVRAENKIGVGPPLDS 18619
Score = 217 bits (530), Expect = 4e-55
Identities = 236/1040 (22%), Positives = 413/1040 (39%), Gaps = 74/1040 (7%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
LPP+I+ Q + G K E + K +W K E+ S+H+ + L
Sbjct: 19825 LPPKILMPEQIT-IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSIL 19883
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAY-LTVEIP 1221
I D D+G YS NS T ++ ++ P F + + DA L+ IP
Sbjct: 19884 IIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIP 19943
Query: 1222 --DETLDVTWY-KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD----AK 1274
D ++T Y +K + + T ++ V K + + K + + + ++
Sbjct: 19944 LEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISE 20003
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
T K+ V +FP + + R+ + + + V + I+ I +K +++
Sbjct: 20004 PLTSPKM-VAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNS 20062
Query: 1335 KPSIDSKSASLTIKKVENTDAGI-----YKLRLE--NNCGHADVEMN---VTILDKPSPP 1384
+ K+ ++ E AG+ Y R+ N G + VT PP
Sbjct: 20063 LLWV--KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPP 20120
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN----ITKTQTSI 1440
GKP ++++ S++++ W P++ G S II Y VE ++ +W+ I + + +
Sbjct: 20121 GKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTA 20180
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI-TTEPNEDI 1499
L+ + Y+FRA A V+IS SE ++ ++ E + +K++ T + ++
Sbjct: 20181 TGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNV 20240
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFND 1555
L G P P V+W +DG LK A+ A N Y A N
Sbjct: 20241 CLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENS 20300
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G + + + KP S +K D A++ PP E + N + +
Sbjct: 20301 SGSKSATIKLKVLDKPGPPAS---VKINKMYSDR----AMLSWEPPLEDGGSEITNYIVD 20353
Query: 1616 DKEYN------ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYD 1664
+E + ++ + +++L H ++ I A N G + + YD
Sbjct: 20354 KRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYD 20413
Query: 1665 KPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE 1724
P + + PVI I+++ +T+ WKPP DDGG +T Y +EK E W KV
Sbjct: 20414 PPGRCDPPVISN-ITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIER 20472
Query: 1725 TYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
T L E EY FRV A N G + ++ P SV
Sbjct: 20473 TLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPAPPAFPKVYDTTRSSV 20532
Query: 1785 YITWFPSEKNGGSPIIDYKVEIKQ-EGKKW---KXXXXXXXXXARIQKLSINTTYQFRIY 1840
++W +GGSPII Y VE+K+ + W + L +T YQFR+Y
Sbjct: 20533 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVY 20592
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSEST--SRSVTLKWTEPESNGGSPIT 1898
A N+IG S P DK L PP + + ++ VT++ P P
Sbjct: 20593 AVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKI 20652
Query: 1899 NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
+ ++ + I + C EN+ + D + ++ EN+ G + +
Sbjct: 20653 TWSKPNVNLRDRIGLDIKSTDFDTFLRC-ENVNKYDAGKYILTLENSCG-----KKEYTI 20706
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
+ K P PP + ++ + + +W P DGG+P++ Y + RD + W V
Sbjct: 20707 VVKVLDTPGPPVN-VTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTV-T 20764
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTE 2078
+ + F + +L E +Y R++A NE G+ +P E+ + K A + PG +
Sbjct: 20765 TECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVK--------ASQTPGPVVD 20816
Query: 2079 VXXXXXXXXXXXXXWLREHN 2098
+ W + H+
Sbjct: 20817 LKVRSVSKSSCSIGWKKPHS 20836
Score = 217 bits (529), Expect = 5e-55
Identities = 266/1201 (22%), Positives = 467/1201 (38%), Gaps = 92/1201 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F++K+ T S+ F+ V G P ITW + D Q+ +DDNV
Sbjct: 5975 PSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLK---------DDQILDEDDNVYI-- 6023
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
F S L + + + H T A +L
Sbjct: 6024 --------------------SFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLL 6063
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
P +K K+ V E + LEC + PE + WL G++IVP S++ E+++
Sbjct: 6064 VQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVA 6123
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+ +I +V K G YT N G +S L++ + PP + L M G
Sbjct: 6124 SF----RIQSVMKQDSGQYTFKVENDFGSSSCDAYLRV-LDQNIPPSFTKKLTKMDKVLG 6178
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITI-LKPKKVKDEGVYTLKA 807
S+ + +V G+ + W K+ K + + + S+++ + +++D YT K
Sbjct: 6179 SSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKV 6238
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
N G S ++TV+EP +P R Q I T++ A + P I W+
Sbjct: 6239 SNVAGDDACSGILTVKEPPSFLVKP----GRQQAI---PDSTVEFKAILKGTPPFKIKWF 6291
Query: 868 RNN-EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+++ E++S + +G L + +VD+ +G Y C +N G S + + E
Sbjct: 6292 KDDVELVSGPKCFI-GLEGSTSFLNLYSVDAS-KTGQYTCHVTNDVGSDSCTTMLLV-TE 6348
Query: 927 KVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXX 984
FVK L+ S + G + LEC+ S + W+ N+ E+ D +
Sbjct: 6349 PPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVI 6408
Query: 985 XXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C ++ ST ++VKE P F E + LE E+
Sbjct: 6409 QMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEP-PVFSSFPPIVETLKNAEVSLECEL 6467
Query: 1041 N-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----S 1095
+ + +VVW +D ++ K KY + ++I N D GEY C ++E +
Sbjct: 6468 SGTPPFEVVWYKDKRQLRSSK-KYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDT 6526
Query: 1096 CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSE-IQFSNHIQ 1153
C V + E PP +++L + V G A + + + V+W K+ E I+ S +I+
Sbjct: 6527 CVCTVKLKE-PPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIR 6585
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPEFILVP 1209
+T L+ + +AG+Y C++ G + A L V EP++ P + V
Sbjct: 6586 ITFVENVATLQFAKAEPANAGKYICQIKNDGGMEENMATLMVLEPAVIVEKAGPMTVTVG 6645
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
V E L V WYK ++ ++K K +L I D YT
Sbjct: 6646 ETCTLECKVAGTPE-LSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQ 6704
Query: 1270 LLD--AKSTTKLKVEVVE--FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI-VN 1324
+ + KS+ V+V + PP + G+ L + W
Sbjct: 6705 VQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEK 6764
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+KI+ K+ + + +L + ++++D G Y N G + +T+ + PS
Sbjct: 6765 TKIVSGAKY-QTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFV 6823
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTSIQNL 1443
+P LE+ N+ + + + +E+ + ++ T + + N+
Sbjct: 6824 KEPEPLEVLPGK-NVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNI 6882
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTC 1503
+ S + N + AS TT + +KE K L + + EP + I L
Sbjct: 6883 DISQSGEYTCVVSN--NAGQASCTTRLF--VKE----PAAFLKRLSDHSVEPGKSIILES 6934
Query: 1504 IFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
+ G VTW +DG + T++ T E Y C N+ G
Sbjct: 6935 TYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRD 6994
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
+V + P E ++ VGD + + G P V WYK KL EY
Sbjct: 6995 VCGALVSTLEPPYFVTELEPLEA--AVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEY 7052
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREIS 1679
+ + ++ + S +YT +A N+ GT+S + ++ ++ P +++I
Sbjct: 7053 RTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIE 7112
Query: 1680 R 1680
+
Sbjct: 7113 Q 7113
Score = 215 bits (525), Expect = 1e-54
Identities = 135/442 (30%), Positives = 209/442 (47%), Gaps = 13/442 (2%)
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYDKPSKPEGPVIMREISR 1680
K + R+K L ++ + A N AG S+ + +K P P G ++++ +
Sbjct: 14865 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 14924
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
SV + W P DGG ++ Y IE + + W++VA+ + + + L E EY FR
Sbjct: 14925 TSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQ-HLLPGLMEGQEYSFR 14983
Query: 1741 VIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
V A N G SE E S+P++ + L PS N + + W EK+GGSPI
Sbjct: 14984 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKN-TADLKWTVPEKDGGSPI 15042
Query: 1800 IDYKVEIKQEGKK-WKXXXXXXXXX-ARIQKLSINTTYQFRIYARNEIGTSLPYTS-DDK 1856
+Y VE + +K W+ + L+ + Y FR+ A N IG S YT +D
Sbjct: 15043 TNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQS-DYTEIEDS 15101
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
+ T T P P V + T R V LKW P+++GG PI Y+IE K G W K
Sbjct: 15102 VLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAG 15161
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIR 1976
G + ++ E E+ F++ AEN GV P+E + + T P P L +
Sbjct: 15162 KTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVT 15221
Query: 1977 MVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRD-LSENH 2035
G + +W PE +GG+P++GY++ + V WM V + LKF + + + +
Sbjct: 15222 DAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 15281
Query: 2036 TYMIRIYARNEIGLSEPLESDE 2057
Y++R+ A N IG+SEP E E
Sbjct: 15282 EYVLRVRAVNAIGVSEPSEISE 15303
Score = 215 bits (525), Expect = 1e-54
Identities = 213/871 (24%), Positives = 352/871 (40%), Gaps = 56/871 (6%)
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVE 1285
+W K I ++ + S L I+ T D EYT + T +KV V++
Sbjct: 21339 SWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD 21398
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
P E + +T + P +I+ + + T S D +S
Sbjct: 21399 VPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRH 21458
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEMN--VTILDK---PSPPGKPNILEIDSSSINIC 1400
K+ + I+++ N+ G + + V ++D+ P PP KP + + ++ +
Sbjct: 21459 VATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVS 21518
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI-SVKN-ITKTQTSIQNLKTNSSYRFRAYAVNE 1458
W P + G S I Y VE +E + W+ ++K ++ + + L+ S+Y FR A N
Sbjct: 21519 WKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENR 21578
Query: 1459 VDISDASETTEYYKVIKETKIQSP--------TVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
I SE ++ + P T +K +P+ D L V
Sbjct: 21579 AGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEH 21638
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV--VGIQ 1568
KV D +K T ++ A ND G E + + V I
Sbjct: 21639 QKVG---DEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIV 21695
Query: 1569 QKPVITISNEDIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
++ + D + + + G + I+G P PEV W K+ L+N NI
Sbjct: 21696 EREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKN--RANIENT 21753
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI-MR--EISRE 1681
E +++ I E R + K+ + N AG S V ++V D P GPV+ +R +I+++
Sbjct: 21754 ESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTP----GPVLNLRPTDITKD 21809
Query: 1682 SVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRV 1741
SVT+ W PL DGG +T Y +EK E + A TY + L+E CEY FRV
Sbjct: 21810 SVTLHWDLPLIDGGSRITNYIVEKREATRKSY-STATTKCHKCTYKVTGLSEGCEYFFRV 21868
Query: 1742 IAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
+A+N G E E+ EP+ A P I +V + W + +GGS I
Sbjct: 21869 MAENEYGIGEPTETTEPVKASEAPSPPDSLNIMD----ITKSTVSLAWPKPKHDGGSKIT 21924
Query: 1801 DYKVEIKQEGK-KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
Y +E +++G +W ++ L+ Y F++ A N G S P S I
Sbjct: 21925 GYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVK 21984
Query: 1860 GKTLTPPSQPRNFVVSESTSRSV-TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV 1918
+T+ P R +++ +K P P + + +K T
Sbjct: 21985 EQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETT 22044
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMV 1978
S + E ++ D + ++A N VG + ++ H +P PPT P++ V
Sbjct: 22045 ATSTILNINECVRS-DSGPYPLTARNIVG----EVGDVITIQVH-DIPGPPTGPIKFDEV 22098
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S+ V SW PE DGG P+ Y + +R T W+E+ + T + L+ Y
Sbjct: 22099 SSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT-TYKATRLTTGLEYQ 22157
Query: 2039 IRIYARNEIGLSEPLES-----DEPFKVIPG 2064
R+ A+N G+ + S + PFKV PG
Sbjct: 22158 FRVKAQNRYGVGPGITSACIVANYPFKV-PG 22187
Score = 213 bits (521), Expect = 4e-54
Identities = 239/1100 (21%), Positives = 425/1100 (38%), Gaps = 56/1100 (5%)
Query: 596 TELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD--ILEGIPPTFSKKPKAQYVDEGSDILL 653
T +I + DH E A +++ P +K + V G
Sbjct: 4343 TLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKF 4402
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C + + P W G EI + S+ Y S L+I + G YT A
Sbjct: 4403 TCEIQSAPNVRFQWFKAGREIYESDKCSIRSSK----YISSLEILRTQVVDCGEYTCKAS 4458
Query: 714 NREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNK 773
N G S L + E PP + KS+ G++ V G P W K+
Sbjct: 4459 NEYGSVSCTATLTVT--EAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGA 4516
Query: 774 PVKALPT--KSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ P SD + I L ++D GVY+ KA N G A + + +
Sbjct: 4517 ALSPSPNWKISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELII-------ID 4569
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELV 891
P FI + + + L +V + ++TW ++ + + P + F+ + L
Sbjct: 4570 KPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLE 4629
Query: 892 ITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQ 951
I + DSG Y C ASN AG SS A VT+ E +FVK + SY G++ L C+
Sbjct: 4630 IPLAKLK-DSGTYVCTASNEAGSSSCSATVTVR-EPPSFVKKVDPSYLMLPGESARLHCK 4687
Query: 952 T--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC-IVKD---QE 1005
S + W+ N KE+S + + D G C V D
Sbjct: 4688 LKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDS 4747
Query: 1006 TSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYD 1064
ST +V+KE P FI+ L+ ++ A+L+ E++ + ++ W +D + I+ K KY
Sbjct: 4748 CSTEIVIKEP-PSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSK-KYR 4805
Query: 1065 FEKRGHIRKLYIRNTSVHDEGEYSCILRDE--SCTAEVT-VVELPPEIITRLQNQKVNKG 1121
+ + L I + + D GEY C++ +E C T +++ PP + ++ + G
Sbjct: 4806 LFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGG 4865
Query: 1122 NKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + + + V W K I+ I+++ L I D + G+Y+C
Sbjct: 4866 QTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLA 4925
Query: 1179 --EVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSV 1235
E G+ L V+EP+ + E I V A A L + L WYK
Sbjct: 4926 ENEAGSQTSVGELIVKEPA--KIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRP 4983
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYER 1295
+ ++K+ + L D +YT + + ++ + I +
Sbjct: 4984 LVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFT 5043
Query: 1296 EYRIKRGSDV--TLLVDYQ-AFPQP-NDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
+ S V T +D + A P W + K I + + +ASL I +V+
Sbjct: 5044 KPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVD 5103
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
DAG + R N+ G D + + + PS KP ++ S + + T
Sbjct: 5104 MNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLT 5163
Query: 1412 IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
I ++ + + K ++ + +KT+ S + N + S
Sbjct: 5164 IRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANL--- 5220
Query: 1472 KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----A 1527
+KE + VEK + + + +L C G P K+TW+ + +++K + +
Sbjct: 5221 -FVKE---PATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMS 5276
Query: 1528 TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVG 1587
E+ Y C A N+ G S +V +++ P T + I+ +
Sbjct: 5277 FVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEY- 5335
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
+ ++ A + G PP E+ W+K+ L + ++Y ++ ++I + + + +Y
Sbjct: 5336 -DVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRV 5394
Query: 1648 SNTAGTSSVEVTLKVYDKPS 1667
+N G+S + + + PS
Sbjct: 5395 TNEVGSSICSARVTLREPPS 5414
Score = 213 bits (521), Expect = 4e-54
Identities = 206/899 (22%), Positives = 374/899 (41%), Gaps = 44/899 (4%)
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTL 1244
T I + P I+ L E + A T L I + + WYK ++ +
Sbjct: 27789 TCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCV 27848
Query: 1245 ISDVKKRTLIIRKCTEDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
+ +++I+ + Y L +A ++ ++V++++ P E++
Sbjct: 27849 ENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKPGP-PGGPIEFKTVTA 27907
Query: 1303 SDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKL 1360
+TLL A +IV + + + S + +T K+ + I+++
Sbjct: 27908 EKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRV 27967
Query: 1361 RLENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
R N G + + +++ K P PPG P + +I +S+ + W P G S I Y
Sbjct: 27968 RAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGY 28027
Query: 1416 VVEYQEIDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
+E ++ + W V + I T+ + L NS Y++R AVN SE +E+YK
Sbjct: 28028 FLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKA 28087
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIF--GGVPQPKVTWYRDGKKLK--TAKATY 1529
P + + + T ++ G V R G++ + T
Sbjct: 28088 ADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKG 28147
Query: 1530 ENRXXXXXXXXXXXXXXXY-KCIAFNDHGEVE-TSCVVGIQQKPVITISNEDIKQK---- 1583
E R Y + A N G+ E +Q K ++ D+
Sbjct: 28148 EVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTS 28207
Query: 1584 --HKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
K G++ V +G PPP V W K+ L +D Y+I + +S++ I ++ R+ +
Sbjct: 28208 VIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTG 28267
Query: 1642 KYTIEASNTAG-TSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTK 1700
KY + N G S V++KV D P+ + + ++ +SR +VT+ W PPL DGG +
Sbjct: 28268 KYILTIENGVGEPKSSTVSVKVLDTPAACQ-KLQVKHVSRGTVTLLWDPPLIDGGSPIIN 28326
Query: 1701 YAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIV 1759
Y IEK + W V ++ + L+E + FRV+A+N +G E E +EP+
Sbjct: 28327 YVIEKRDATKRTW-SVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPV- 28384
Query: 1760 IKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXX 1818
A +VP+ SV ++W + +GGS I +Y VE K +G++ W
Sbjct: 28385 --KAAEVPAPIRDLSMKDS-TKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGI 28441
Query: 1819 XXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSEST 1878
+ +L + +FR++A+NE G S P T +TP + ++ T
Sbjct: 28442 SKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVT 28501
Query: 1879 SR-SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEII 1937
R + P P +++ + +K + + + I+N K++
Sbjct: 28502 VRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKI-TLSIKNAKKEHGGK 28560
Query: 1938 FRISAENTV-GVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGA 1996
+ + +N V +++P ++ PS P P+ + ++ V+ SW PE +GG
Sbjct: 28561 YTVILDNAVCRIAVPITVITL------GPPSKPKGPIRFDEIKADSVILSWDVPEDNGGG 28614
Query: 1997 PLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
+ Y+I R+ ++T W V V F + +L ++ Y R+ A N G+S+PL S
Sbjct: 28615 EITCYSIEKRETSQTNWKMVCS-SVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVS 28672
Score = 208 bits (508), Expect = 2e-52
Identities = 225/926 (24%), Positives = 383/926 (41%), Gaps = 55/926 (5%)
Query: 1161 QKLKIYDCDLDDAG--EYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
Q+ KI C L+ G E + G K L E P ++ L + I+V A A + +
Sbjct: 24916 QEYKIRVCALNKVGLGEATSVPGTVKPEDKL--EAPELDLDSELRKGIVVRAGGSARIHI 24973
Query: 1219 EIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
T ++TW +++ E T+K + V L I C +D +Y L ++ +
Sbjct: 24974 PFKGRPTPEITWSREEG--EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSK 25031
Query: 1278 K--LKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ V+V++ P + +K + + ++ P + V + +I K + T+
Sbjct: 25032 SAFVTVKVLDTPGP----PQNLAVKEVRKDSAFLVWEP-PIIDGGAKVKNYVIDKRESTR 25086
Query: 1336 PSIDSKSA--SLTIKKVEN-TDAGIYKLRL--ENNCG-HADVEM--NVTILDKPSPPGKP 1387
+ + S+ S T KVEN T+ IY R+ EN G VE V + PSPPGK
Sbjct: 25087 KAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKV 25146
Query: 1388 NILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNS 1447
+ ++ +S ++ W++PE+ G S ++ YVVE Q T +W V + L +
Sbjct: 25147 TLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQ 25206
Query: 1448 SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
Y+FR A NE SD + K+ IQ P+++ P + + ED+++ G
Sbjct: 25207 EYQFRVKAYNEKGKSD-PRVLGVPVIAKDLTIQ-PSLKLPFNTYSIQAGEDLKIEIPVIG 25264
Query: 1508 VPQPKVTWYRDGKKLK-TAKATYENRXXXX---XXXXXXXXXXXYKCIAFNDHGEVETSC 1563
P+P ++W +DG+ LK T + E Y A N G +
Sbjct: 25265 RPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENL 25324
Query: 1564 VVGIQQK---PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
V + +K PV + +++ V W A G I K +
Sbjct: 25325 SVIVLEKPGPPVGPVRFDEVSADFVV-ISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVS 25383
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS----SVEVTLKVYDKPSKPEGPVIMR 1676
T T I+I +LK ++ I A N G S S V ++ K P G +
Sbjct: 25384 ATVARTT--IKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVT 25441
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCE 1736
IS++ + ++W P++DGG ++ Y +E+ E ++ W+K+ + L+E E
Sbjct: 25442 SISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLE 25501
Query: 1737 YMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNG 1795
Y F+V A+N VG + + SE V + D P I +V + W +G
Sbjct: 25502 YEFKVSAENIVGIGKPSKVSECFVARDPCDPPG----RPEAIVITRNNVTLKWKKPAYDG 25557
Query: 1796 GSPIIDYKVEIKQ--EGKKWKXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGT-SLPY 1851
GS I Y VE K +G+ K + L + Y+FR+ ARN G S P
Sbjct: 25558 GSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPS 25617
Query: 1852 TSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS 1911
S IT + P+ + + + G PI + + + +
Sbjct: 25618 DSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEE 25677
Query: 1912 WTKIVTVGGSVHEH--CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP 1969
+ + ++ + +++ D + + N G T+S + + K P PP
Sbjct: 25678 TAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGG----TKSIPITV-KVLDRPGPP 25732
Query: 1970 TAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIR 2029
PL++ V + +W P DGGA + Y I R+ ++ W +V +V L + +
Sbjct: 25733 EGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV-STEVQALNYKVT 25791
Query: 2030 DLSENHTYMIRIYARNEIGLSEPLES 2055
L + Y+ R+ A N+ G+ EPLES
Sbjct: 25792 KLLPGNEYIFRVMAVNKYGIGEPLES 25817
Score = 208 bits (507), Expect = 2e-52
Identities = 223/960 (23%), Positives = 396/960 (41%), Gaps = 70/960 (7%)
Query: 750 ESVILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ VIL ++ P + W K+ K P K K+DG + ILK D G YT
Sbjct: 12960 DEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKKRML-ILKKALKSDIGQYTCD 13017
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
G +TS + +E+ + P + V E T + ++ + + + W
Sbjct: 13018 C----GTDKTSGKLDIEDREIKLVRP------LHSVEVMETETARFETEISEDDIHA-NW 13066
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
E + + +G+ LV+ N + +G A+N KSS RV V
Sbjct: 13067 KLKGEALLQTPDCEIKEEGKIHSLVLHNCRLD-QTGGVDFQAANV--KSSAHLRVKPRV- 13122
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
+ ++ L K G+T +C+ S+ + +WY K++ D EG+
Sbjct: 13123 -IGLLRPL-KDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLT 13180
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G ++ KD +T L VKE EF + L+D V+E A+LE E++ E A
Sbjct: 13181 LRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENA 13240
Query: 1046 DVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
V W ++G EI+K KK Y+ G +RKL I + + D Y+C +D + + VV
Sbjct: 13241 KVKWFKNGTEILKSKK--YEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVP 13298
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
E + L + +V + A FE EL++ +A V+WFKDG+EI+ + G + L
Sbjct: 13299 PHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILV 13358
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
I C LDD EYSCEV ++ + +LTV E FT L I V L E+
Sbjct: 13359 INKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLAN-IEVSETDTIKLVCEVSKPG 13417
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+V WYK I +T ++ ++++ +KR L+I+ +D Y C L S T KV+V
Sbjct: 13418 AEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRL--PSSRTDGKVKVH 13475
Query: 1285 EFPPKIVDYEREYRIKRG--SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
E + + + I G ++ + ++FP +W + K ++ D K
Sbjct: 13476 ELAAEFISKPQNLEILEGEKAEFVCSISKESFPV---QWKRDDKTLESGDKYDVIADGKK 13532
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS--PPGKPNILEIDSSSINIC 1400
L +K D G Y + + G A ++T+++K P K ++ + C
Sbjct: 13533 RVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNC 13588
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
NT + ++ E D++++I ++ I++ + + N
Sbjct: 13589 ---EVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRG 13645
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK 1520
+ S +++E ++ + +PLK+I T + + C + + W ++G+
Sbjct: 13646 ENVKSAAN---LIVEEEDLR---IVEPLKDIETMEKKSVTFWCKVNRL-NVTLKWTKNGE 13698
Query: 1521 KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE--VETSCVVGIQQKPVITISNE 1578
++ ++NR K F D GE V + + +I E
Sbjct: 13699 EV-----PFDNR--VSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTE 13751
Query: 1579 DIKQKHKVGDEWLVTAVIE---GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
++ AV V WY+NG +++ K+Y + IK+
Sbjct: 13752 FVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDC 13811
Query: 1636 KRSHSSKYTIEASNTAGTSSV---EVTLKVYDKPSK-PEGP----VIMREISRESVTIEW 1687
+ +Y + + + E+ +++ P E P V + E++++ V ++W
Sbjct: 13812 RLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQW 13871
Score = 205 bits (501), Expect = 1e-51
Identities = 229/937 (24%), Positives = 390/937 (41%), Gaps = 70/937 (7%)
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
+ ++ K++IY + + GE + G K + E ++ LR + + + A L
Sbjct: 22750 ENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLR--KVVTIRACCTLRL 22807
Query: 1217 TVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
V I +V W + E +K ++ S LI+ D +Y + ++
Sbjct: 22808 FVPIKGRPAPEVKWARDHG--ESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSG 22865
Query: 1276 TTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH 1333
+ + V V++ P D + + K + VTL D P + + + I++K +
Sbjct: 22866 SKSAFVNVRVLDTPGPPQDLKVKEVTK--TSVTLTWDP---PLLDGGSKIKNYIVEKRES 22920
Query: 1334 TKPSIDSKSASL--TIKKVENTDAGI---YKLRLENNCG---HADVEMNVTILDKPSPPG 1385
T+ + + + + T KV+ G +++ EN G A+ +V ++P PPG
Sbjct: 22921 TRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPG 22980
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKT 1445
K ++++ +S+++ W++PE+ G S I+ Y+VE Q + +W + + T+ +I L
Sbjct: 22981 KITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQ 23040
Query: 1446 NSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF 1505
Y FR A NE ISD + + VI + + P + T ED+++ F
Sbjct: 23041 GEEYSFRVSAQNEKGISDPRQLS--VPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPF 23098
Query: 1506 GGVPQPKVTWYRDGKKLK-----TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
G P P VTW++D LK A++T EN Y N GE
Sbjct: 23099 IGRPTPAVTWHKDNVPLKQTTRVNAEST-ENNSLLTIKDACREDVGHYVVKLTNSAGEAI 23157
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN----D 1616
+ V + KP +K DE ++ PP+ Y G+ + N
Sbjct: 23158 ETLNVIVLDKP--GPPTGPVKM-----DEVTADSITLSWGPPK---YDGGSSINNYIVEK 23207
Query: 1617 KEYNITTKEKTS------VIRIKELKRSHSSKYTIEASNTAGTSSV---EVTLKVYD-KP 1666
++ + TT + S I+ LK ++ I A N G S+ E T+ Y K
Sbjct: 23208 RDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKV 23267
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
P G ++ SR+S+ ++W P+ DGG + Y +E+ E ++ W+K+ +
Sbjct: 23268 PGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKF 23327
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
L E EY FRV A+N VG + + SE V + D P + SV
Sbjct: 23328 KTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPG----RPEAIIVTRNSVT 23383
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQ--EGKKWKXX-XXXXXXXARIQKLSINTTYQFRIYAR 1842
+ W +GGS I Y VE K+ EG+ K + L + Y+FR+ AR
Sbjct: 23384 LQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIAR 23443
Query: 1843 NEIGT-SLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
N G S P S IT + PP + ++ + G PI I
Sbjct: 23444 NAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPT-I 23502
Query: 1902 IEFKTVKGKSWTKIVTVGGS--VHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
K + S T + + + +++ D + + A+N G T + V L
Sbjct: 23503 QWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKV-L 23561
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
++ P PP P+ I V + +W P DGG+ ++ Y + R+ ++ +W V
Sbjct: 23562 DR----PGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVV-DA 23616
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
+V TL + L E + Y RI A N+ G+ EPLES+
Sbjct: 23617 NVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESE 23653
Score = 205 bits (500), Expect = 2e-51
Identities = 242/1076 (22%), Positives = 420/1076 (39%), Gaps = 69/1076 (6%)
Query: 633 PPTFSKKPKA-QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP--DENISVAIESDMH 689
PP F KK +A + V G LEC++ PE + W F+ E +P D+ I+S
Sbjct: 6349 PPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVW-FRNEHELPASDKYRMTFIDS--- 6404
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLP--IVLKIKTGEKEPPQVIEPLKSMIVR 747
+V+++ N+ G + A N G S +++K P ++E LK+
Sbjct: 6405 --VAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNA--- 6459
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYT 804
V L ++ G P + W K+ + + K S SI IL D G Y
Sbjct: 6460 ---EVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVD-TSDIGEYH 6515
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
KA+N G + V TV+ EPP F+++ +TV +L A + +
Sbjct: 6516 CKAQNEVG--SDTCVCTVKLK-----EPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFV 6568
Query: 865 TWYRNNE-IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W + E +I SE I F EN+ + ++G Y C N G + A + +
Sbjct: 6569 QWLKEKEEVIRESENIRITFV-ENVATLQFAKAEPANAGKYICQIKNDGGMEENMATLMV 6627
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRX 981
+E V+ T G+T LEC+ + T +S +WY + K ++ + +
Sbjct: 6628 -LEPAVIVEKAGPMTVTV-GETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKI 6685
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVV----KETIPEFIRKLQDFEVKEKDVAI 1035
D G V++ ++S VV + P F R+L++ I
Sbjct: 6686 SSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCI 6745
Query: 1036 LEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD- 1093
LE ++ S V W + I KY ++ L + + D G Y+C+ +
Sbjct: 6746 LECKVAGSSPISVAWFHEKTKIVSGA-KYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANV 6804
Query: 1094 ---ESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFS 1149
+ C A +TV E PP + + +V G TF + V WF+ E+
Sbjct: 6805 AGSDECRAVLTVQE-PPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKG 6863
Query: 1150 NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEF 1205
+ + + +L++++ D+ +GEY+C V N+ CT L V+EP+ F RL +
Sbjct: 6864 DRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAA-FLKRLSDH 6922
Query: 1206 ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
+ P + + + VTW K I +EK +++ K L I T+ D +
Sbjct: 6923 SVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQ 6982
Query: 1266 YTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
Y+C + + + V +E PP V G V+L P+ W
Sbjct: 6983 YSCEIENEAGRDVCGALVSTLE-PPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYK 7041
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
++ + + A+L KV D+G Y + EN+ G A + I ++ P
Sbjct: 7042 GDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLP 7101
Query: 1384 PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE---IDTTEWISVKNITKTQTSI 1440
P L+ ++ + S I V Y++ + E + + T +
Sbjct: 7102 PSFARQLKDIEQTVGLPVTLTCRLNGSAPIQ-VCWYRDGVLLRDDENLQTSFVDNVAT-L 7159
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+ L+T+ S+ + + AS + +E K +SP + +I E +
Sbjct: 7160 KILQTDLSHSGQYSCSASNPLGTASSSARL--TAREPK-KSPFFDIKPVSIDVIAGESAD 7216
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFNDH 1556
C G ++TW +D K+++ N Y C A ND
Sbjct: 7217 FECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDV 7276
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
G+ S + +++ P + + + K G+ + I G P +V W++N ++L
Sbjct: 7277 GKDMCSAQLSVKEPPKF-VKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHES 7335
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+YN++ +++ I E S Y EA N G +S L V P + P
Sbjct: 7336 WKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKP 7391
Score = 205 bits (500), Expect = 2e-51
Identities = 228/1047 (21%), Positives = 410/1047 (39%), Gaps = 71/1047 (6%)
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
+E+ P + V + ++ + A V W KDG ++ + + ++
Sbjct: 26318 IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVT 26377
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCT-----AILTVEEPSINFTLRLPEFILVPANTDAYL 1216
L I + +D G Y V NS + I+ ++ P +R+ E + + T ++
Sbjct: 26378 SLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDE-VSCDSITISWN 26436
Query: 1217 TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLI--IRKCTEDDQCEYTCV--LLD 1272
E D ++ Y + + + ++S RT I +R T + C
Sbjct: 26437 PPEY-DGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYG 26495
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
S ++ V E+P ++ + T+LV +Q ++ + + K
Sbjct: 26496 KSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHL--EYK 26553
Query: 1333 HTKPSIDSKSASLTIK----KVENTDAGI---YKLRLENNCGHADVEMN---VTILDKPS 1382
+ SK+ + I KV D G+ Y++ EN G + V D
Sbjct: 26554 ERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCD 26613
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK--NITKTQTSI 1440
PPG+P + I S+++ W +P G + I Y+VE +E+ W+ NI +T +
Sbjct: 26614 PPGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEV 26673
Query: 1441 QNLKTNSSYRFRAYAVNEVD-ISDASETTEYYKVIKETKIQSPTVEKPLKN---ITTEPN 1496
L + Y FR +A N D +S+ SE+T +I + ++ P V +K I +
Sbjct: 26674 TELTEDQRYEFRVFARNAADSVSEPSESTG--PIIVKDDVEPPRVMMDVKFRDVIVVKAG 26731
Query: 1497 EDIELTCIFGGVPQPKVTWYRDG----KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIA 1552
E +++ G P P ++W +DG ++ +T + +N Y
Sbjct: 26732 EVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTL 26791
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIK--QKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
N G + + KP +I K W G ++ +Y
Sbjct: 26792 KNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGA---DIDYYIVE 26848
Query: 1611 NKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAGTSSV--EVTLKVYDKPS 1667
+ + + I E + + ++ +L + + + + N G V +K D +
Sbjct: 26849 KRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFT 26908
Query: 1668 KPEGPVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P P + +++ES+T+ W P DGG E++ Y IE+ E ++ RW++V + V
Sbjct: 26909 VPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNK--KPVYD 26966
Query: 1726 YCIQK--LNENCEYMFRVIAQNPVGFSEALESEPIV-IKTALDVPSXXXXXXXXXXIDNE 1782
++ L E CEY +RV A+N G S E+ P++ + + +PS
Sbjct: 26967 LRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDS-GKT 27025
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXXXXXXXXA-RIQKLSINTTYQFRIY 1840
++ I W +GG+PI Y VE K+ + WK I L+ Y FR+
Sbjct: 27026 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 27085
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
+ N++G S P S D + P + + ++ +T G P+ N
Sbjct: 27086 SVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPN- 27144
Query: 1901 IIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLE 1960
++ K V S IEN D + ++ +N + + T +
Sbjct: 27145 VLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLT-----LVV 27199
Query: 1961 KHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD 2020
K P PPT + ++ V + SW PE DGGAP+ Y+I R+ +K W+ V +
Sbjct: 27200 KVLDTPGPPTN-ITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTN-N 27257
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVX 2080
N L + + +L E Y R+ NE G+ P E+ E K+ E+P ++
Sbjct: 27258 CNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKI--------TEKPSPPEKLG 27309
Query: 2081 XXXXXXXXXXXXWLR-EHNMDADIRSY 2106
WL+ EH+ + I Y
Sbjct: 27310 VTSISKDSVSLTWLKPEHDGGSRIVHY 27336
Score = 202 bits (494), Expect = 8e-51
Identities = 174/670 (25%), Positives = 270/670 (40%), Gaps = 36/670 (5%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMN 1374
P P W + K + ++ +KS L IK D G Y + N+CG
Sbjct: 16059 PVPTKVWTKEEGELDKDRVVIDNVGTKS-ELIIKDALRKDHGRYVITATNSCGSKFAAAR 16117
Query: 1375 VTILDKPSP--PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN 1432
V + D P P KP + +N W +PE+ G S I +++E ++ W
Sbjct: 16118 VEVFDVPGPVLDLKPVVTNRKMCLLN--WSDPEDDGGSEITGFIIERKDAKMHTWRQPIE 16175
Query: 1433 ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNIT 1492
+++ I L Y+FR A N+ E V SP +
Sbjct: 16176 TERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTK 16235
Query: 1493 TEPNEDIELTCIFGGVP-QPKVTWYR--DGKKLKTAKATYENRXXXXXXXXXXXXXXXYK 1549
+ D + GG P Q + R D + ++
Sbjct: 16236 STITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFR 16295
Query: 1550 CIAFNDHGEVETSCVVGI-----QQKPVITI--SNEDIKQKHKVGDEWLVTAVIEGIPPP 1602
A N+ GE E S + + + P I + S K K G+ + A + G+P P
Sbjct: 16296 VKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMP 16355
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTS------VIRIKELKRSHSSKYTIEASNTAGTSSV 1656
++ W KN +E + TKE+ S + I + R YT+ ASN G+
Sbjct: 16356 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 16415
Query: 1657 EVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WI 1714
V ++VYD+PS P + + +I ES + W PLD+GG E+T Y I+K + + W
Sbjct: 16416 NVHVEVYDRPSPPRN-LAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWE 16474
Query: 1715 KVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXX 1774
+V + + + Y I KL N +Y FRV A N G S+ +S+ +VI+ +P
Sbjct: 16475 EVTNTAVE-KRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPK 16533
Query: 1775 XXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSINT 1833
S+ ++W P NGGSPI Y +E ++EG W ++ + N
Sbjct: 16534 VLARTKG-SMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNV 16592
Query: 1834 T-------YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKW 1886
YQFR A N G P D G + PP P V + T S++L W
Sbjct: 16593 PRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGW 16652
Query: 1887 TEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVH--EHCIENIKEKDEIIFRISAEN 1944
P +GGSPI YI+E + W ++ + E + N+KE + FR+ A N
Sbjct: 16653 KPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVN 16712
Query: 1945 TVGVSLPTES 1954
G S P+++
Sbjct: 16713 EAGESEPSDT 16722
Score = 202 bits (494), Expect = 8e-51
Identities = 217/903 (24%), Positives = 372/903 (41%), Gaps = 67/903 (7%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVT-WYKKKSVIEDTEKFTLISDVKKRT 1252
PS+ ++L E ++V A T I + W S I+ E +T+ +D
Sbjct: 18435 PSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV 18494
Query: 1253 LIIRKCTEDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD 1310
L I+ C D EY + +A T + + V++ P I + + +
Sbjct: 18495 LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTG---PINILDVTPEHMTIS 18551
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPS--IDSKSASLTIKKVENTDAG---IYKLRLENN 1365
+Q ++N I++K K + + S +S T K+ + G ++++R EN
Sbjct: 18552 WQPPKDDGGSPVINY-IVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENK 18610
Query: 1366 CGHAD-VEMNVTI----LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
G ++ T+ PSPPGKP + +I ++ + W P++ G S I Y +E +
Sbjct: 18611 IGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERR 18670
Query: 1421 EIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK 1478
E+ T +W+ V I + + L ++Y FR +A N +S S +++ K + K
Sbjct: 18671 EV-TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIK 18729
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXX 1538
P + LK+ + E D+ T P + + + +K TA+ N+
Sbjct: 18730 PPGPPINPKLKDKSRE-TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQ 18788
Query: 1539 XXXXX------XXXXYKCIAFNDHGE------VETSCVVGIQQKPVIT--ISNEDIKQKH 1584
++ A N GE E+ I P + ++ D+
Sbjct: 18789 CAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITV- 18847
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VG + A ++G P P++ W K G L +K ++ ++IKE R+ KY
Sbjct: 18848 RVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYI 18907
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
I A N++G + + V D+P P + + +++E+ TI W+ PLD+GG E+T + +E
Sbjct: 18908 ISAKNSSGHAQGSAIVNVLDRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVE 18966
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQ-KLNENCEYMFRVIAQNPVGFSEALESE-PIVIKT 1762
+P+ W VA DV I+ L N EY FRV A+N VG +E++ PI+
Sbjct: 18967 YRKPNQKGWSIVAS---DVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAIN 19023
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXX 1821
+D P VY+ W + +GGSP + Y VE + +G W+
Sbjct: 19024 PIDRPGEPENLHIADK-GKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSI 19082
Query: 1822 XXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTS 1879
+ + N Y+FR+ +NE G S + +++ + + L P V+ S
Sbjct: 19083 KETHYMVDRCVENQIYEFRVQTKNEGGES-DWVKTEEVVVKEDLQKP------VLDLKLS 19135
Query: 1880 RSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-------VTVGGSVHEHCIENIKE 1932
+T+K + E K K T + + + + K
Sbjct: 19136 GVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKR 19195
Query: 1933 KDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW 1992
D + ++A NT G + + +V L+K P L+I V S+ W PE
Sbjct: 19196 SDGGKYVVTATNTAGSFVAYATVNV-LDKPG-----PVRNLKIVDVSSDRCTVCWDPPED 19249
Query: 1993 DGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
DGG + Y I + TK M V T + L E + Y+ R+ A N+IG P
Sbjct: 19250 DGGCEIQNY-ILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPP 19308
Query: 2053 LES 2055
ES
Sbjct: 19309 TES 19311
Score = 202 bits (493), Expect = 1e-50
Identities = 182/753 (24%), Positives = 322/753 (42%), Gaps = 44/753 (5%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V E + EC + P+ WL +EI D+ + + H V+K +
Sbjct: 12778 VFEKDEAKFECEVSREPKT-FRWLKGTQEITGDDRFELIKDGTKHSM--VIKSAAFE--D 12832
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
E Y A ++ L I+ I+ + + PLK + ++ ES + + ++ +
Sbjct: 12833 EAKYMFEAEDKHTSGKL-IIEGIRL------KFLTPLKDVTAKEKESAVFTVEL-SHDNI 12884
Query: 765 TITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
+ W KN++ + +++ + +G THSIT K + D ++A + A +T
Sbjct: 12885 RVKWFKNDQRLHTTRSVSMQDEGKTHSITF-KDLSIDDTSQIRVEAMGMS----SEAKLT 12939
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
V E P F + Q+ T EK + L +++ P + W+++ + I PS+
Sbjct: 12940 VLEGD------PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVI 12992
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE 941
DG+ L++ + D G Y C G ++ I+ ++ V+ L S E
Sbjct: 12993 KADGKKRMLILKKA-LKSDIGQYTC----DCGTDKTSGKLDIEDREIKLVRPLH-SVEVM 13046
Query: 942 EGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
E +T E + S + W + + EI +EG+ G +
Sbjct: 13047 ETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQ 13106
Query: 1001 VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKK 1060
+ ++S L VK + +R L+D V + A + E++ E V W G+ ++P
Sbjct: 13107 AANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPS- 13165
Query: 1061 NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNK 1120
+K G + L +R+ + D GE +D A + V E P E L++Q V +
Sbjct: 13166 DKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEE 13225
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
G A E E+++ +A V+WFK+G+EI S ++ DG+ +KL I+DC +D Y+C+
Sbjct: 13226 GATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDA 13285
Query: 1181 GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE 1240
+ K + L V P + F L + + V A E+ E V W+K + I+ +
Sbjct: 13286 KDFKTSCNLNVVPPHVEFLRPLTD-LQVREKEMARFECELSRENAKVKWFKDGAEIKKGK 13344
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV--EVVEFPPKIVDYEREYR 1298
K+ +IS R L+I KC DD+ EY+C + A+++ L V E F + + E
Sbjct: 13345 KYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVSE- 13403
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
+D LV + P W + I + + + + L I+ DAG Y
Sbjct: 13404 ----TDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNY 13459
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
RL ++ V+++ + S P ILE
Sbjct: 13460 NCRLPSSRTDGKVKVHELAAEFISKPQNLEILE 13492
Score = 202 bits (493), Expect = 1e-50
Identities = 187/693 (26%), Positives = 290/693 (41%), Gaps = 34/693 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQT 1438
P P P + + S+ + W+ P + G S I+ YV+E ++ + W I + +
Sbjct: 23664 PDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRL 23723
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
+ L N Y FR A N +S+ S + Y K P + +IT
Sbjct: 23724 RVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFL 23783
Query: 1499 IELTCIF-GGVP-QPKVTWYRD---GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
I+ GG Q + D G+ T N+ ++ A
Sbjct: 23784 SWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAI 23843
Query: 1554 NDHGEVETSCVVG---IQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIW 1606
N G E + V G +++K P I + E K + + G + I+G P PEV W
Sbjct: 23844 NKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW 23903
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
K ++ + ++T+ TS++ + + R S KYT+ N++GT S VT++V D P
Sbjct: 23904 GKVDGEIRDAAIIDVTSSF-TSLV-LDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTP 23961
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
S P + + EI+++SV+I W+PPL DGG ++ Y +EK E + V + ++
Sbjct: 23962 SPPVN-LKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVV-TNCHKNSW 24019
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFS-EALESEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
I +L E C Y FRV A+N G A ++PI + P + SV
Sbjct: 24020 KIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPG----KITVDDVTRNSVS 24075
Query: 1786 ITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNE 1844
++W E +GGS II Y VE++ + +KW A I L+ Y FR+ A NE
Sbjct: 24076 LSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNE 24135
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEF 1904
G S P + I + K L + S S LK P S P + +
Sbjct: 24136 KGRSDPRSLAVPI-VAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDG 24194
Query: 1905 KTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHA 1963
+ K T+I VT + I+ + D + I+ N VG + V L+K
Sbjct: 24195 LPL--KQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVG-QKTASIEIVTLDK-- 24249
Query: 1964 TVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
P PP P++ V + + SW P + GG + Y + RD T T+W +V V
Sbjct: 24250 --PDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVW-DVVSATVAR 24306
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
+ L Y RI+A N G S LESD
Sbjct: 24307 TTLKVTKLKTGTEYQFRIFAENRYGQSFALESD 24339
Score = 200 bits (488), Expect = 4e-50
Identities = 172/697 (24%), Positives = 288/697 (41%), Gaps = 38/697 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK---TQ 1437
P PP P++ + S ++ W +P G I YVVE+Q++ WI T TQ
Sbjct: 21600 PGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ 21659
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE 1497
+ +L+T Y FR A+N+ + + + + V +E + + +
Sbjct: 21660 FVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGL 21719
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXX-XXXXXYKCIAFNDH 1556
I + G P P+VTW +D LK +A EN K + ++
Sbjct: 21720 SIRIFVPIKGRPAPEVTWTKDNINLKN-RANIENTESFTLLIIPECNRYDTGKFVMTIEN 21778
Query: 1557 GEVETSCVVGIQ----QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
+ S V ++ PV+ + DI K V W + + G + Y +
Sbjct: 21779 PAGKKSGFVNVRVLDTPGPVLNLRPTDIT-KDSVTLHWDLPLIDGG---SRITNYIVEKR 21834
Query: 1613 LENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS-VEVT--LKVYDKPSK 1668
K Y+ TTK ++ L + + A N G E T +K + PS
Sbjct: 21835 EATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP 21894
Query: 1669 PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCI 1728
P+ IM +I++ +V++ W P DGG ++T Y IE +++W + V + +E +
Sbjct: 21895 PDSLNIM-DITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV-KGLECV-V 21951
Query: 1729 QKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXI-----DNES 1783
+ L E EY F+V+A N G S ES P+++K +P + DN
Sbjct: 21952 RNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIK 22011
Query: 1784 VYITWFPSEKNGGSPIIDYKV--EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
V I K P + +K +I ++ ++ I + + + + + A
Sbjct: 22012 VEIPVLGRPK----PTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTA 22067
Query: 1842 RNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
RN +G + I + PP+ P F E +S VT W PE++GG PI+NY+
Sbjct: 22068 RNIVGEVGDVIT---IQVHDIPGPPTGPIKF--DEVSSDFVTFSWDPPENDGGVPISNYV 22122
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
+E + +W ++ T + + E FR+ A+N GV S +
Sbjct: 22123 VEMRQTDSTTWVELATTVIRT-TYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 22181
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
VP PP P ++ V + + SW P DGG+P+LGY++ ++ +W V K V
Sbjct: 22182 PFKVPGPPGTP-QVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALV 22240
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
F L++ Y R+ A N G S+P + EP
Sbjct: 22241 PGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEP 22277
Score = 199 bits (485), Expect = 1e-49
Identities = 194/869 (22%), Positives = 358/869 (41%), Gaps = 53/869 (6%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVV 1284
VTW + + ++ T+ + +++I+ C Q Y+ + + K + V+V+
Sbjct: 17483 VTWNMNERTLP--QEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 17540
Query: 1285 EFP-PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
+ P P + +T P +++ + + T +
Sbjct: 17541 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 17600
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHAD-VEMNVTILDK-----PSPPGKPNILEIDSSSI 1397
+ T++ + A +++ EN+ G VE + ++ + P P + E+ +++
Sbjct: 17601 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 17660
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYA 1455
+ W+ P+ G S II YV+E + I T ++ V N + + +++ LK +Y +R A
Sbjct: 17661 TLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSA 17720
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNEDIELTCIFGGVPQPKVT 1514
VN V S T+ + + ++ PT+ ++ +T E LT + G P+PKV+
Sbjct: 17721 VNIVGQGKPSFCTK--PITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVS 17778
Query: 1515 WYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
W++D + +T T Y + N G + C V + +
Sbjct: 17779 WFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDR 17838
Query: 1571 ---PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
PV +S +++ + + V W G I K ++ D +T+
Sbjct: 17839 PGPPVGPVSFDEVTKDYMV-ISWKPPLDDGGSKITNYIIEK--KEVGKDVWMPVTSASAK 17895
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSS--VEVTLKVYDK---PSKPEGPVIMREISRES 1682
+ ++ +L + I A N G S V ++K D+ P P+ P++ E++++S
Sbjct: 17896 TTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIV-TEVTKDS 17954
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEYMFRV 1741
+ W P DGG +T Y +EK E + RW +V D + + L E C+Y FRV
Sbjct: 17955 ALVTWNKP-HDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRV 18013
Query: 1742 IAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
A+N +G + + S+P+ K + PS N SV +TW P +GGS I+
Sbjct: 18014 SAENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCN-SVDLTWQPPRHDGGSKIL 18072
Query: 1801 DYKVEIKQEG-KKWKXXXXX----XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDD 1855
Y VE ++ G ++W+ ++ L TY+FR+ A N G S P +
Sbjct: 18073 GYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE 18132
Query: 1856 KITIGKTLTPPS--QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWT 1913
+ + L PP N + TL+ + P + E + K+
Sbjct: 18133 PVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARI 18192
Query: 1914 KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPL 1973
+ VG + I N +D I+ ++ EN G S + + L+K P PP L
Sbjct: 18193 DVTPVGSKLE---IRNAAHEDGGIYSLTVENPAG-SKTVSVKVLVLDK----PGPP-RDL 18243
Query: 1974 EIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSE 2033
E+ + + +W P DGG+ + Y + RDV W + F + L+E
Sbjct: 18244 EVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHF-AKHLNE 18302
Query: 2034 NHTYMIRIYARNEIGLSEPLESDEPFKVI 2062
+ Y+ R+ A N+ G +E+ +P K +
Sbjct: 18303 GNQYLFRVAAENQYGRGPFVETPKPIKAL 18331
Score = 198 bits (483), Expect = 2e-49
Identities = 131/433 (30%), Positives = 196/433 (45%), Gaps = 19/433 (4%)
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN--GNKLENDKEYNITTKEK 1626
QKPV+ + + K GD + A + G P PEV W K+ L I T+
Sbjct: 19126 QKPVLDLKLSGVLTV-KAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRAD 19184
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+S + + KRS KY + A+NTAG+ T+ V DKP I+ ++S + T+
Sbjct: 19185 SSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIV-DVSSDRCTVC 19243
Query: 1687 WKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNP 1746
W PP DDGG E+ Y +EK E W + T + +L E EY+FRV A+N
Sbjct: 19244 WDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT-TVTRLIEGNEYIFRVRAENK 19302
Query: 1747 VGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
+G ES+P++ KT D P + E + + W P E +GG I Y +E
Sbjct: 19303 IGTGPPTESKPVIAKTKYDKPGRPDPPEVTK-VSKEEMTVVWNPPEYDGGKSITGYFLEK 19361
Query: 1807 KQE-GKKWKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTL 1863
K++ +W R +Q L + YQFR+ A NEIG P + +
Sbjct: 19362 KEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPI 19421
Query: 1864 TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK-----TVKGKSWTKIVTV 1918
PP P NF V ++T S+TL W +P +GG+PI Y++E + + W +
Sbjct: 19422 EPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAA 19481
Query: 1919 GGSVH-EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM 1977
V E + ++ E E FR+ A+N VG+ P E + K + PP L+ M
Sbjct: 19482 AQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKE--ILEPPEIDLDASM 19539
Query: 1978 VGSNIVMTSWGTP 1990
+V+ G P
Sbjct: 19540 --RKLVIVRAGCP 19550
Score = 196 bits (477), Expect = 9e-49
Identities = 175/699 (25%), Positives = 298/699 (42%), Gaps = 44/699 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKTQ 1437
P PP P + + SS+++ W +P G + + YVVE +E EW + + Q
Sbjct: 25930 PGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQ 25989
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITTE 1494
++ LK N+ Y FR A+N + + + T V+ + +I+ P +E K +
Sbjct: 25990 FTVTKLKENTEYNFRICAINSEGVGEPA--TLPGSVVAQERIEPPEIELDADLRKVVVLR 26047
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCI 1551
+ + L G P+P+V W + + + T +A E + Y
Sbjct: 26048 ASATLRLFVTIKGRPEPEVKWEK-AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLT 26106
Query: 1552 AFNDHGEVETSCVVGIQQKP--VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
N+ G V + P + ++ ++K K V W +I+G ++ Y
Sbjct: 26107 LENNSGSKTAFVNVRVLDSPSAPVNLTIREVK-KDSVTLSW-EPPLIDG--GAKITNYIV 26162
Query: 1610 GNKLENDKEY-NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS-SVEVTLKV-YDKP 1666
+ K Y IT + RI+ L+ S + + ASN G E T V +P
Sbjct: 26163 EKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEP 26222
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
P G V + +++R + TI+W+ P DGG ++T Y +E + +W V + +E
Sbjct: 26223 PLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQV-KTLEA- 26280
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
I L EY+FRV A N G S+ + P++ + PS E +
Sbjct: 26281 TISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLK 26340
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXAR-IQKLSINTTYQFRIYARNE 1844
I P + G P V +++G+ K ++ + LSI ++ +
Sbjct: 26341 ID-VPFK---GRP--QATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEA------SKED 26388
Query: 1845 IGTSLPYTSDD--KITIGKT---LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
+GT S+ IT+ T L P P + E + S+T+ W PE +GG I+N
Sbjct: 26389 VGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISN 26448
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
YI+E K +W IV+ + I + E FR+ AEN G S +ES +V
Sbjct: 26449 YIVEKKETTSTTW-HIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVA 26507
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
E + P PP P + S +++T W P DGG+ ++GY++ ++ + +W + K+
Sbjct: 26508 EYPFSPPGPPGTPKVVHATKSTMLVT-WQVPVNDGGSRVIGYHLEYKERSSILWSKANKI 26566
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ + + L E Y R+YA N G+ + +S EP
Sbjct: 26567 LIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEP 26605
Score = 195 bits (475), Expect = 2e-48
Identities = 186/711 (26%), Positives = 309/711 (43%), Gaps = 65/711 (9%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKTQ 1437
P+PP P + + SS+++ W +P G S II Y+VE + D+ W+ +N+ KT+
Sbjct: 20516 PAPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTR 20575
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL-KNITTEPN 1496
+ L ++ Y+FR YAVN++ SD S+ + + ++ L K +
Sbjct: 20576 FEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAG 20635
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTA-----KATYENRXXXXXXXXXXXXXXXYKCI 1551
+ L G P PK+TW + L+ K+T + Y
Sbjct: 20636 VTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKST-DFDTFLRCENVNKYDAGKYILT 20694
Query: 1552 AFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT---AVIEGIPPPEVIWYK 1608
N G+ E + VV + P + N +K+ K D VT +I+G P +I Y
Sbjct: 20695 LENSCGKKEYTIVVKVLDTPGPPV-NVTVKEISK--DSAYVTWEPPIIDGGSP--IINYV 20749
Query: 1609 NGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ K ++ T E KTS R+ L+ S + + A N G T K
Sbjct: 20750 VQKRDAERKSWSTVTTECSKTS-FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAV-KA 20807
Query: 1667 SKPEGPVI---MREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
S+ GPV+ +R +S+ S +I WK P DGG + Y ++ + N+W +V +
Sbjct: 20808 SQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVD-FLTEENKWQRVMK-SLSL 20865
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNES 1783
+ Y + L E EY FRV A+N G E SE I + DV + +D +
Sbjct: 20866 Q-YSAKDLTEGKEYTFRVSAENENG--EGTPSE-ITVVARDDVVAPD--------LDLKG 20913
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGK-----KWKXXXXXXXXXARI--QKLSINTTYQ 1836
+ + +++N +++++I +GK WK R+ + ++NTT
Sbjct: 20914 LPDLCYLAKENS-----NFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLI 20968
Query: 1837 FRIYARNEIGT------SLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEP 1889
+++ G ++ T + I+I K + P P + E T+ ++TLKW P
Sbjct: 20969 VYDCQKSDAGKYTITLKNVAGTKEGTISI-KVVGKPGIPTGPIKFDEVTAEAMTLKWAPP 21027
Query: 1890 ESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC--IENIKEKDEIIFRISAENTVG 1947
+ +GGS ITNYI+E + W VT +V + + + E E FR+SAEN G
Sbjct: 21028 KDDGGSEITNYILEKRDSVNNKW---VTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYG 21084
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRD 2007
V +S+ + VP P P I V + V +W P+ GG+P+ GY++ ++
Sbjct: 21085 VGEGLKSEPIVARHPFDVPDAPPPP-NIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKE 21143
Query: 2008 VTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+W K + F + L+E Y R+ A N G+ +P EP
Sbjct: 21144 RNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEP 21194
Score = 194 bits (474), Expect = 2e-48
Identities = 212/907 (23%), Positives = 361/907 (39%), Gaps = 56/907 (6%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVK 1249
+E P I+ L L + I + A L V I T +V W K I D + S
Sbjct: 23864 LEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFT 23923
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
+L++ D +YT L ++ T + V V++ P V+ + K +T
Sbjct: 23924 --SLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITW 23981
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCG 1367
+IV + + + + S I +++ + +++ EN G
Sbjct: 23982 EPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYG 24041
Query: 1368 ---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
A + + + P PPGK + ++ +S+++ W +PE+ G S II Y+VE Q +
Sbjct: 24042 IGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHS 24101
Query: 1425 TEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
+W + Q I NL Y FR AVNE SD ++ + + P V
Sbjct: 24102 EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLA--VPIVAKDLVIEPDV 24159
Query: 1485 EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX 1544
+ + + + +D+++ G P+P +TW +DG L K T
Sbjct: 24160 KPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPL---KQTTRINVTDSLDLTTLSI 24216
Query: 1545 XXXYKCIAFNDHGEVETSCVVGIQQK----PVITISNED-IKQKHKVGDEWLVTAVIEGI 1599
+K +D G+ + + QK ++T+ D K K D + +
Sbjct: 24217 KETHK----DDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWN 24272
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTS------VIRIKELKRSHSSKYTIEASNTAGT 1653
PP + N + ++ T + S +++ +LK ++ I A N G
Sbjct: 24273 PPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQ 24332
Query: 1654 S-SVEVTLKVYDKPSK---PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
S ++E V P K P G IS++S+ I+W P+++GG + Y +E+ E +
Sbjct: 24333 SFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERN 24392
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPS 1768
+ W KV + Q L E EY FRV A+N VG +A + SE V + D P
Sbjct: 24393 SILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPG 24452
Query: 1769 XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGKKWKXXXXXXXXXA-R 1825
+ + + W +GGS I Y VE + +G+ K
Sbjct: 24453 ----TPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 24508
Query: 1826 IQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKTLTPP--SQPRNFVVSESTSRSV 1882
+ L+ + Y+FR+ A+N G S P S IT + P S F + +
Sbjct: 24509 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGE 24568
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
T + P ++ K ++ + +I +++ D + + A
Sbjct: 24569 TFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKA-LLIVKDAIRIDGGQYILRA 24627
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
N G ++S V + K P PP P+++ V S +W P DGG+ + Y
Sbjct: 24628 SNVAG----SKSFPVNV-KVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYV 24682
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES-----DE 2057
+ R+ ++ W V +V T + L E + Y+ RI A N+ G+ EPLES
Sbjct: 24683 VEKRETSRLAWTVVAS-EVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKN 24741
Query: 2058 PFKVIPG 2064
PF V+PG
Sbjct: 24742 PF-VLPG 24747
Score = 192 bits (467), Expect = 2e-47
Identities = 176/700 (25%), Positives = 303/700 (43%), Gaps = 46/700 (6%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK---NIT 1434
+D P PP K I + SSI + W +P G S + YVVE ++ + EW +V +
Sbjct: 28091 IDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVR 28150
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNI 1491
T+ + NLK +Y FR AVN + E E V + +++P ++ + ++
Sbjct: 28151 TTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNE--PVQAKDILEAPEIDLDVALRTSV 28208
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXX---XXXXXXXX 1547
+ ED+++ F G P P VTW +D K L A+ + EN
Sbjct: 28209 IAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGK 28268
Query: 1548 YKCIAFNDHGEVETSCV-VGIQQKPVITISNEDIKQKH-KVGDEWLV--TAVIEGIPPPE 1603
Y N GE ++S V V + P + + ++ KH G L+ +I+G P
Sbjct: 28269 YILTIENGVGEPKSSTVSVKVLDTPA---ACQKLQVKHVSRGTVTLLWDPPLIDGGSP-- 28323
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTSS-VEVT-- 1659
+I Y + + +++ + + +S ++ +L + + A N G E T
Sbjct: 28324 IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEP 28383
Query: 1660 LKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADV 1719
+K + P+ P + M++ ++ SV + W P DGG +T+Y +E+ W A +
Sbjct: 28384 VKAAEVPA-PIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTW-SHAGI 28441
Query: 1720 DRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXI 1779
+ E + +L E FRV A+N G S+ + PI +K + P +
Sbjct: 28442 SKTCEIE-VSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQV 28500
Query: 1780 D---NESVYITWFPSEKNGGSPIIDYKVE--IKQEGKKWKXXXXXXXXXARIQKLSINTT 1834
+V++ P K P I + + +E + + I+
Sbjct: 28501 TVRIGHNVHLE-LP-YKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHG 28558
Query: 1835 YQFRIYARNEI-GTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEPESN 1892
++ + N + ++P T IT+G PPS+P+ + E + SV L W PE N
Sbjct: 28559 GKYTVILDNAVCRIAVPIT---VITLG----PPSKPKGPIRFDEIKADSVILSWDVPEDN 28611
Query: 1893 GGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
GG IT Y IE + +W K+V + + N+ + E FR+ AEN GVS P
Sbjct: 28612 GGGEITCYSIEKRETSQTNW-KMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL 28670
Query: 1953 ESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM 2012
S + + +P PP P+ I V S+ + +W P +DGG+ + G+++ ++ +
Sbjct: 28671 VSSIIVAKHQFRIPGPPGKPV-IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSIL 28729
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
W +V ++ ++ L E Y R+YA N GLS P
Sbjct: 28730 WQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSP 28769
Score = 191 bits (466), Expect = 2e-47
Identities = 205/757 (27%), Positives = 301/757 (39%), Gaps = 73/757 (9%)
Query: 1349 KVENTDAG-IYKLRL--ENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWD 1402
KV AG IY+ R+ EN G + V +D PP I +I +S+++ W
Sbjct: 27657 KVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQ 27716
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEV- 1459
+P G S I Y+VE +++ W S N+T+TQ I L NS Y FR +A N V
Sbjct: 27717 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 27776
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKN---ITTEPNEDIELTCIFGGVPQPKVTWY 1516
IS+ SE I P ++ PL+ + ++L G P P + WY
Sbjct: 27777 SISNPSEVVGPITCIDS--YGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWY 27834
Query: 1517 RDGKKLKT-AKATYENRXXXXXXXXXXXXXXXYKCIAF---NDHGEVETSCVVGIQQKP- 1571
+D K+L+T A EN C N G + V I KP
Sbjct: 27835 KDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKPG 27894
Query: 1572 -------VITISNEDI----KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
T++ E I + G + ++E V+W LE E
Sbjct: 27895 PPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE---ECI 27951
Query: 1621 ITTKEKTSVIRIKE--LKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
ITT T +I+ E + +KY I + SV V + P P P + + I
Sbjct: 27952 ITT---TKIIKGNEYIFRVRAVNKYGI--GEPLESDSV-VAKNAFVTPGPPGIPEVTK-I 28004
Query: 1679 SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEY 1737
++ S+T+ W P+ DGG +++ Y +EK + + W KV + RD + L EN +Y
Sbjct: 28005 TKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQK-VTGLTENSDY 28063
Query: 1738 MFRVIAQNPVGFSEALESEPIVIKTALDV--PSXXXXXXXXXXIDNESVYITWFPSEKNG 1795
+RV A N G + SEP A D P S+ + W +G
Sbjct: 28064 QYRVCAVNAAG--QGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDG 28121
Query: 1796 GSPIIDYKVEIKQ-EGKKWKXXXXXXXXXAR---IQKLSINTTYQFRIYARNEIGTSLPY 1851
GS + Y VEI+Q E ++W + L Y FR+ A N G P
Sbjct: 28122 GSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPI 28181
Query: 1852 TSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK--TVKG 1909
++ P Q ++ + + V L+ T + G + +I FK
Sbjct: 28182 EMNE----------PVQAKDILEAPEIDLDVALR-TSVIAKAGEDV-QVLIPFKGRPPPT 28229
Query: 1910 KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVP--- 1966
+W K GS + IEN + N G + T V K +TV
Sbjct: 28230 VTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKV 28289
Query: 1967 -SPPTA--PLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
P A L+++ V V W P DGG+P++ Y I RD TK W V +T
Sbjct: 28290 LDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSST 28349
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
F + DLSE + R+ A NEIG+ EP E+ EP K
Sbjct: 28350 -SFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVK 28385
Score = 190 bits (462), Expect = 6e-47
Identities = 204/900 (22%), Positives = 371/900 (41%), Gaps = 65/900 (7%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVK 1249
+E P I L + +++ A+ L V I +V W K + ++ D + + S
Sbjct: 26029 IEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFT 26088
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
L+I T D Y L + T + V V++ P V+ +K+ S VTL
Sbjct: 26089 M--LVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIR-EVKKDS-VTL 26144
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS--KSASLTIKKVENTDAGI---YKLRL 1362
+ P + + + I++K + T+ + + + + T ++EN G +++
Sbjct: 26145 SWEP---PLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLA 26201
Query: 1363 ENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEY 1419
N G A+ V + + P PPG+ ++++ ++ I W++PE+ G S I YVVE
Sbjct: 26202 SNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEM 26261
Query: 1420 QEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
Q + +W + + + +I L Y FR AVNE SD + + ++ +I
Sbjct: 26262 QTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQ-LGVPVIARDIEI 26320
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXX 1538
+ P+VE P + E +++ F G PQ V W +DG+ LK T + +
Sbjct: 26321 K-PSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSL 26379
Query: 1539 X---XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV 1595
Y+ N G + + + +P ++ + +
Sbjct: 26380 SIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRP-------GPPGPIRIDEVSCDSIT 26432
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS------VIRIKELKRSHSSKYTIEASN 1649
I PP + N + KE TT S I+I L ++ + A N
Sbjct: 26433 ISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAEN 26492
Query: 1650 TAGTSSV-EVTLKVYDKPSKPEGPVIMREI---SRESVTIEWKPPLDDGGLELTKYAIEK 1705
G SS E + V + P P GP ++ ++ ++ + W+ P++DGG + Y +E
Sbjct: 26493 RYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEY 26552
Query: 1706 HEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTAL 1764
E + W K + + L+E Y +RV A+N G + +S EP+ +
Sbjct: 26553 KERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPC 26612
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGKKWK-XXXXXXX 1821
D P I +SV + W +GG+ I Y VE ++ +G+ K
Sbjct: 26613 DPPG----QPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQE 26668
Query: 1822 XXARIQKLSINTTYQFRIYARNEI-GTSLPYTSDDKITIGKTLTPPSQPRNFVVSE--ST 1878
+ +L+ + Y+FR++ARN S P S I + + PP + +
Sbjct: 26669 TYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVV 26728
Query: 1879 SRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKE---KDE 1935
LK + P+ ++ + ++ ++ T+I+ S H + +K+ +D
Sbjct: 26729 KAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEII----STDNHTLLTVKDCIRRDT 26784
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
+ ++ +N G T S +V K P PP PLEI + + SWG P+ DGG
Sbjct: 26785 GQYVLTLKNVAG----TRSVAVNC-KVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGG 26839
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
A + Y + R+ + W + + ++ + L + + Y+ R+ N+ G+ EPLES
Sbjct: 26840 ADIDYYIVEKRETSHLAW-TICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLES 26898
Score = 187 bits (456), Expect = 3e-46
Identities = 169/699 (24%), Positives = 289/699 (41%), Gaps = 43/699 (6%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKT 1436
KP PP P +++I SS+ + W +P G I Y+VE ++ EW I KT
Sbjct: 23764 KPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKT 23823
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITT 1493
++ L Y FR A+N+ + + ++ +I E K+++P ++ L K I
Sbjct: 23824 NIEVEKLLEKHEYNFRICAINKAGVGEHADVPG--PIIVEEKLEAPDIDLDLELRKIINI 23881
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCI 1551
+ L G P P+V W + +++ A + Y
Sbjct: 23882 RAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLT 23941
Query: 1552 AFNDHGEVETSCVVGI--QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
N G V + P + + +I K V W + G I K
Sbjct: 23942 LENSSGTKSAFVTVRVLDTPSPPVNLKVTEI-TKDSVSITWEPPLLDGGSKIKNYIVEKR 24000
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT---LKVYDKP 1666
+T K S +I +L+ S + + A N G T +KV + P
Sbjct: 24001 -EATRKSYAAVVTNCHKNS-WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVP 24058
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
+P G + + +++R SV++ W P DGG ++ +Y +E + +W + A V + ++
Sbjct: 24059 -QPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARV-KSLQA- 24115
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
I L + EY+FRV+A N G S+ + PIV K + P + +
Sbjct: 24116 VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLK 24175
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXA-RIQKLSINTTY-----QFRI 1839
I S + P I + ++G K + + LSI T+ Q+ I
Sbjct: 24176 IEVPISGR--PKPTITW----TKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 24229
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
N +G S + +T+ K PP P F + ++ S+TL W P GG ITN
Sbjct: 24230 TVANVVGQKT--ASIEIVTLDKP-DPPKGPVKF--DDVSAESITLSWNPPLYTGGCQITN 24284
Query: 1900 YIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
YI++ + W + TV + + + +K E FRI AEN G S ES +
Sbjct: 24285 YIVQKRDTTTTVWDVVSATVARTTLK--VTKLKTGTEYQFRIFAENRYGQSFALESDPIV 24342
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
+ P PP P + ++V+ W P +GG+P++GY++ ++ +W +V K
Sbjct: 24343 AQYPYKEPGPPGTPFATAISKDSMVI-QWHEPVNNGGSPVIGYHLERKERNSILWTKVNK 24401
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
++ +F ++L E Y R+YA N +G+ + ++ E
Sbjct: 24402 TIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSE 24440
Score = 186 bits (452), Expect = 1e-45
Identities = 173/698 (24%), Positives = 291/698 (41%), Gaps = 41/698 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK---NITKT 1436
KP PPG P +L+ SSI+I W++P G S I Y+VE + EW V + T
Sbjct: 22682 KPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKAT 22741
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITT 1493
+I L N Y+ R YA+N + + + K E ++ P +E K +T
Sbjct: 22742 SYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKA--EDRMLPPEIELDADLRKVVTI 22799
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRD-GKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCI 1551
+ L G P P+V W RD G+ L K + + + Y
Sbjct: 22800 RACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILT 22859
Query: 1552 AFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT---AVIEGIPPPEVIWYK 1608
N G V + P +D+K K +T +++G ++ Y
Sbjct: 22860 VENSSGSKSAFVNVRVLDTPG---PPQDLKVKEVTKTSVTLTWDPPLLDG--GSKIKNYI 22914
Query: 1609 NGNKLENDKEYNI--TTKEKTSVIRIKELKRSHSSKYTIEASNTAGT---SSVEVTLKVY 1663
+ K Y+ T KTS ++ +L+ S + + A N G + ++K
Sbjct: 22915 VEKRESTRKAYSTVATNCHKTSW-KVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKAS 22973
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
++P P G + + +++R SV++ W+ P DGG + Y +E +++W A V V
Sbjct: 22974 ERPLPP-GKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVK--V 23030
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
I L + EY FRV AQN G S+ + S P++ K + P+ + E
Sbjct: 23031 TEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGE 23090
Query: 1783 SVYITWFPSEKNGGSPIIDYK--VEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIY 1840
+ + P + +K V +KQ + I+ + +
Sbjct: 23091 DLKVD-VPFIGRPTPAVTWHKDNVPLKQTTRV-NAESTENNSLLTIKDACREDVGHYVVK 23148
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
N G ++ + I + K PP+ P + E T+ S+TL W P+ +GGS I NY
Sbjct: 23149 LTNSAGEAIETLN--VIVLDKP-GPPTGPVK--MDEVTADSITLSWGPPKYDGGSSINNY 23203
Query: 1901 IIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
I+E + +W + TV + + C +K E FRI+AEN G S S+
Sbjct: 23204 IVEKRDTSTTTWQIVSATVARTTIKAC--RLKTGCEYQFRIAAENRYGKSTYLNSEPTVA 23261
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
+ VP PP P+ + + + + W P DGG+ ++GY++ ++ +W+++ K
Sbjct: 23262 QYPFKVPGPPGTPV-VTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKT 23320
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
+ KF L E Y R+ A N +G+ +P + E
Sbjct: 23321 PIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 23358
Score = 184 bits (448), Expect = 3e-45
Identities = 168/704 (23%), Positives = 281/704 (39%), Gaps = 46/704 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP P + + + ++ W +P + G S I+ YVVE Q+ T +W + I +
Sbjct: 18731 PGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCA 18790
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN---ITTE 1494
+ L + YRFR A N V + E E VI + + P VE + IT
Sbjct: 18791 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAE--SVIAKDILHPPEVELDVTCRDVITVR 18848
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT--YEN--RXXXXXXXXXXXXXXXYKC 1550
+ I + G P+P +TW ++GK L K ++ R Y
Sbjct: 18849 VGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYII 18908
Query: 1551 IAFNDHGEVETSCVVGIQQKPVITISNEDIKQ--KHKVGDEWLVTAVIEGIPPPEVIWYK 1608
A N G + S +V + +P N + K W G E+ +
Sbjct: 18909 SAKNSSGHAQGSAIVNVLDRPG-PCQNLKVTNVTKENCTISWENPLDNGG---SEITNFI 18964
Query: 1609 NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG------TSSVEVTLKV 1662
+ N K ++I + T + L ++ + + A N G T + + +
Sbjct: 18965 VEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINP 19024
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
D+P +PE + + + + V ++W+ P DGG Y +E+ ++ W +V
Sbjct: 19025 IDRPGEPEN-LHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIK 19083
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
Y + + EN Y FRV +N G S+ +++E +V+K L P +
Sbjct: 19084 ETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAG 19143
Query: 1783 SVYITWFPSEKNGGSPII----DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFR 1838
I + P + D + K + K + ++
Sbjct: 19144 DT-IRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 19202
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPIT 1898
+ A N G+ + Y + + L P RN + + +S T+ W PE +GG I
Sbjct: 19203 VTATNTAGSFVAYATVN------VLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQ 19256
Query: 1899 NYIIEFKTVKGKSWTK----IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
NYI+E K W+ ++T G +V + E +E IFR+ AEN +G PTES
Sbjct: 19257 NYILEKCETKRMVWSTYSATVLTPGTTV-----TRLIEGNEYIFRVRAENKIGTGPPTES 19311
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
+ V + P P P E+ V + W PE+DGG + GY + ++ T W+
Sbjct: 19312 KPVIAKTKYDKPGRPDPP-EVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWV 19370
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
V K + + +++L +H Y R+ A NEIG+ EP P
Sbjct: 19371 PVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRP 19414
Score = 184 bits (448), Expect = 3e-45
Identities = 168/697 (24%), Positives = 286/697 (41%), Gaps = 35/697 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK---NITKT 1436
KP PP +I++ +SI + W +P G S I+ YVVE + D EW V + T
Sbjct: 24846 KPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVT 24905
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE---KPLKNITT 1493
+ I L + Y+ R A+N+V + +A+ K E K+++P ++ + K I
Sbjct: 24906 RFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVK--PEDKLEAPELDLDSELRKGIVV 24963
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKC 1550
+ F G P P++TW R+ + T K E N Y
Sbjct: 24964 RAGGSARIHIPFKGRPTPEITWSREEGEF-TDKVQIEKGVNYTQLSIDNCDRNDAGKYIL 25022
Query: 1551 IAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLV--TAVIEGIPPPEVIWYK 1608
N G V + P N +K+ K +LV +I+G +V Y
Sbjct: 25023 KLENSSGSKSAFVTVKVLDTPGPP-QNLAVKEVRK-DSAFLVWEPPIIDG--GAKVKNYV 25078
Query: 1609 NGNKLENDKEY-NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD--K 1665
+ K Y N+++K + +++ L + + A N G T+ +
Sbjct: 25079 IDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAE 25138
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P P G V + ++S+ S ++ W+ P DGG + Y +E +W VA+ V
Sbjct: 25139 PPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAE--SKVCN 25196
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEA-LESEPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
+ L+ EY FRV A N G S+ + P++ K PS E +
Sbjct: 25197 AVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDL 25256
Query: 1785 YITWFPSEKNGGSPIIDYKV-EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
I P I K E ++ + I++ + + ++ + A N
Sbjct: 25257 KIE-IPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATN 25315
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
GT+ T + + + + PP P F E ++ V + W P GG I+NYI+E
Sbjct: 25316 SAGTA---TENLSVIVLEKPGPPVGPVRF--DEVSADFVVISWEPPAYTGGCQISNYIVE 25370
Query: 1904 FKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
+ +W + TV + + I +K E FRI AEN G S P +S++V ++
Sbjct: 25371 KRDTTTTTWHMVSATVARTTIK--ITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYP 25428
Query: 1963 ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
P PP P + + + ++ W P DGG ++GY++ ++ +W+++ K +
Sbjct: 25429 FKEPGPPGTPF-VTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQ 25487
Query: 2023 TLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPF 2059
KF L E Y ++ A N +G+ +P + E F
Sbjct: 25488 DTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF 25524
Score = 184 bits (447), Expect = 4e-45
Identities = 107/367 (29%), Positives = 174/367 (47%), Gaps = 6/367 (1%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G+ + A+++G P P V W+K+G ++E IT ++ + +++ R H YT
Sbjct: 28898 KSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYT 28957
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+EA N +G++ E+ +KV D P K GP+ I+ E +T+ W PL+DG +T Y IE
Sbjct: 28958 VEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE 29017
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTAL 1764
K E W + D + ++Y KL EY FRV A N G L+S+P+V +
Sbjct: 29018 KRETSRLAWALIED-KCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQY 29076
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKW-KXXXXXXXX 1822
VP I S+ +TW E +GGS I Y +E ++ + +W K
Sbjct: 29077 TVPD-APGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPIS 29135
Query: 1823 XAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSR 1880
R + L+ Y+F + A N G I + + PP P V++++
Sbjct: 29136 ETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKT 29195
Query: 1881 SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
+V+L+W++P +GG I YIIE W K+ + + +++ +E FR+
Sbjct: 29196 TVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRV 29255
Query: 1941 SAENTVG 1947
SA N G
Sbjct: 29256 SAINGAG 29262
Score = 183 bits (446), Expect = 5e-45
Identities = 178/727 (24%), Positives = 290/727 (39%), Gaps = 68/727 (9%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV----KNITKT 1436
P PP P + + SSI++ W P G S I Y+VE QE TT+W V K IT
Sbjct: 16632 PGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTC 16691
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEP 1495
+ + NLK YRFR AVNE S+ S+TT + ++ ++ + +
Sbjct: 16692 ECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKA 16751
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------------ATYENRXXXXXXXXXXX 1543
I + + G P PK +W DGK K K T EN
Sbjct: 16752 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRS 16811
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPP 1602
Y A N G+ +C V + P +D+K G L + +
Sbjct: 16812 HTGKYSITAKNKAGQKTANCRVKVMDVPG---PPKDLKVSDITRGSCRLSWKMPDDDGGD 16868
Query: 1603 EVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
+ Y + + K + + ++ + +L + + A N G T++
Sbjct: 16869 RIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQ 16928
Query: 1662 ---VYDKPSKPEGPVIMRE--ISRESVTIEWKPPLDDGGLELTKYAIE--KHEPDNNR-- 1712
D P+ P+ ++ I++ +V + WKPP +DGG +T Y +E +P +
Sbjct: 16929 RTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKE 16988
Query: 1713 -WIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXX 1771
W + D + + ++ L E EY FRV A N G S+ + D+P
Sbjct: 16989 AWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSID 17048
Query: 1772 XXXXXXXIDNESVYI------------TWF---PSEKNGGSPIIDYKVEIKQEGKKWKXX 1816
+ +V I TWF P + + P++ Y + +
Sbjct: 17049 LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVL-YDTHVNK-------L 17100
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE 1876
I + + T + I A N +GT+ + + ++ + PP P F E
Sbjct: 17101 VVDDTCTLVIPQSRRSDTGLYTITAVNNLGTA---SKEMRLNVLGRPGPPVGPIKF---E 17154
Query: 1877 STSRS-VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
S S +TL W P+ +GGS ITNY+IE + K+W + + + I + E E
Sbjct: 17155 SVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKEC-TYTIPKLLEGHE 17213
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
+FRI A+N G+ P +S+ +VP P P + V N + +W PE+DGG
Sbjct: 17214 YVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPT-VSSVTRNSMTVNWEEPEYDGG 17272
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTL----KFNIRDLSENHTYMIRIYARNEIGLSE 2051
+P+ GY + ++D T W V + + + + + L E Y R+YA N G+
Sbjct: 17273 SPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGP 17332
Query: 2052 PLESDEP 2058
+P
Sbjct: 17333 ASLPSDP 17339
Score = 182 bits (443), Expect = 1e-44
Identities = 246/1098 (22%), Positives = 447/1098 (40%), Gaps = 107/1098 (9%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
GI F + Q V EG C L + + + W ++ + ++ E H
Sbjct: 12498 GIRLKFMSPLEDQTVKEGETATFVCEL-SHEKMHVVWFKNDAKLHTSRTVLISSEGKTHK 12556
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ +E T ++ + L ++K E +P ++ V + E
Sbjct: 12557 L----------EMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKDE 12606
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKA 807
+ L +V + + W K+ + + P K+DG I +K +KD+G Y
Sbjct: 12607 -ITLKCEV--SKDVPVKWFKDGEEIVPSPKYSIKADG-LRRILKIKKADLKDKGEYVCDC 12662
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
G +T A +TVE + E PL+ E+ V E ++ P W
Sbjct: 12663 ----GTDKTKANVTVEARLIK-VEKPLY---GVEVFVGETAHFEIELS---EPDVHGQWK 12711
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ ++ S DG+ L++ N + +G+ A+N+ KS+ A + +
Sbjct: 12712 LKGQPLTASPDCEIIEDGKKHILILHNCQLGM-TGEVSFQAANA--KSA--ANLKVKELP 12766
Query: 928 VTFVKHLQ--KSYETEEGKTVILECQTSHTVST-KWYHNKKEISGMDHREIIQEGRXXXX 984
+ F+ L K +E +E K EC+ S T +W +EI+G D E+I++G
Sbjct: 12767 LIFITPLSDVKVFEKDEAK---FECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSM 12823
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D +D+ TS L+++ +F+ L+D KEK+ A+ VE++ +
Sbjct: 12824 VIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELSHDN 12883
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
V W ++ + + ++ + G + ++ S+ D + S A++TV+E
Sbjct: 12884 IRVKWFKNDQRLHTTRS-VSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLE 12942
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P +LQ+ + ++ + E++K DA V+WFKDG EI+ S + + DGKK+ L
Sbjct: 12943 GDPYFTGKLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLI 13002
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G+Y+C+ G K + L +E+ I L ++ T + T EI ++
Sbjct: 13003 LKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFET-EISEDD 13061
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + T + + K +L++ C D + KS+ L+V+
Sbjct: 13062 IHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVK-- 13119
Query: 1285 EFPPKIVDYER---EYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
P+++ R + + G T + Y+ P EW + K ++ P +
Sbjct: 13120 ---PRVIGLLRPLKDVTVTAGETATFDCELSYEDIPV---EWYLKGKKLEPSDKVVPRSE 13173
Query: 1340 SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINI 1399
K +LT++ V+ DAG +L ++ HA N+ + + P KP LE
Sbjct: 13174 GKVHTLTLRDVKLEDAGEVQLTAKDFKTHA----NLFVKEPPVEFTKP--LE-------- 13219
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
D+ G + ++ V +E +W KN T+ S + + + R R +++
Sbjct: 13220 --DQTVEEGATAVLECEVS-RENAKVKWF--KNGTEILKS-KKYEIVADGRVRKLVIHDC 13273
Query: 1460 ---DISDASETTEYYKVIKETKIQSPTVE--KPLKNITTEPNEDIELTCIFGGVPQPKVT 1514
DI + + +K + P VE +PL ++ E C KV
Sbjct: 13274 TPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSR-ENAKVK 13332
Query: 1515 WYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV-GIQQKPVI 1573
W++DG ++K K Y+ KC+ +D E E SC V + ++
Sbjct: 13333 WFKDGAEIKKGK-KYD-----IISKGAVRILVINKCL-LDD--EAEYSCEVRTARTSGML 13383
Query: 1574 TISNED-IKQKHKVGDEWLVTAVIEGI-----PPPEVIWYKNGNKLENDKEYNITTKEKT 1627
T+ E+ + K+ E T I+ + P EVIWYK ++ Y I T+ +
Sbjct: 13384 TVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRK 13443
Query: 1628 SVIRIKELKRSHSSKYT--IEASNTAGTSSV-EVTLKVYDKPS-----KPEGPVIMREIS 1679
++ I+ + Y + +S T G V E+ + KP + E + IS
Sbjct: 13444 RILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSIS 13503
Query: 1680 RESVTIEWKPPLDDGGLE 1697
+ES ++WK DD LE
Sbjct: 13504 KESFPVQWK--RDDKTLE 13519
Score = 181 bits (440), Expect = 3e-44
Identities = 176/746 (23%), Positives = 300/746 (40%), Gaps = 44/746 (5%)
Query: 795 KKVKDEGVYTLKA---ENSEGIAETSAV-ITVEEPTEENAEP----PLFINRFQEITVKE 846
+K KDE ++ K E + +AE + I +P + P P R Q TV +
Sbjct: 2032 RKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQ 2091
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENI-ELVITNVDSEIDSGDYK 905
RV P P WY+N I S+ I + +N+ ELVI +V +E DS
Sbjct: 2092 GSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAE-DSASIM 2150
Query: 906 CVASNSAGKSSHGARVTIDVEK-VTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHN 963
A N AG++S A + + ++ +TF + LQ E+ EC+TS V KWY +
Sbjct: 2151 VKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKD 2210
Query: 964 KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE---TSTMLVVKETIPEFI 1020
E+ D + + + D C++ + E T+ L+V+ + EF+
Sbjct: 2211 GMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFV 2270
Query: 1021 RKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTS 1080
++LQD EV E LE ++ E + W + +K KY R + L +++ +
Sbjct: 2271 KELQDIEVPESYSGELECIVSPENIEGKWYHNDVELK-SNGKYTITSRRGRQNLTVKDVT 2329
Query: 1081 VHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWF 1140
D+GEYS ++ + T ++ + P I+ L +QKV +G+ E++++ W
Sbjct: 2330 KEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWM 2389
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL 1200
KDG E+Q S+ + + ID + L I D +DAG YS + + V S++
Sbjct: 2390 KDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVIT 2449
Query: 1201 RLPEFILVPANTDAYL--TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
L + + V T A L V +PD T V WY I+ ++ I K+ L+I +
Sbjct: 2450 PLKD-VNVIEGTKAVLECKVSVPDVT-SVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRT 2507
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
D+ Y ++ ++ L VE + KI+ R+ +V V+ + +
Sbjct: 2508 HASDEGPYKLIVGRVETNCNLSVEKI----KIIRGLRDLTCTETQNVVFEVEL-SHSGID 2562
Query: 1319 DEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL 1378
W K IK K K LT+ + D G Y N + + +
Sbjct: 2563 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAGGAI 2622
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT 1438
KP + E + P++ G EW+
Sbjct: 2623 SKPLT--DQTVAESQEAVFECEVANPDSKG-----------------EWLRDGKHLPLTN 2663
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
+I++ R A DI + + K + K+++ ++K LKN+T +D
Sbjct: 2664 NIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2723
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKT 1524
T V W ++G L++
Sbjct: 2724 AVFTVELTHPNVKGVQWIKNGVVLES 2749
Score = 179 bits (436), Expect = 9e-44
Identities = 174/747 (23%), Positives = 309/747 (41%), Gaps = 47/747 (6%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
SK Q V E + + EC VA P+ WL G+ + NI ESD H ++
Sbjct: 2623 SKPLTDQTVAESQEAVFECE-VANPDSKGEWLRDGKHLPLTNNIRS--ESDGHKRRLIIA 2679
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
T + E TY V + + V KIK + LK++ V + + + +
Sbjct: 2680 ATKLDDIGEYTYKVATSKTSAKLKVEAV-KIK----------KTLKNLTVTETQDAVFTV 2728
Query: 757 QVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
++ + W KN +++ G +S+ I K + DE VY + G
Sbjct: 2729 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI-KNCAIVDESVYGFRL----GR 2783
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
SA + VE I + +++T E T+ V+ + VP + W+ N I
Sbjct: 2784 LGASARLHVETVK--------IIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKNVEI 2834
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
PS+ + + +L++ N+ S D+G+Y V G+ A++ ++ +T
Sbjct: 2835 KPSDKHRLVSERKVHKLMLQNI-SPSDAGEYTAVV----GQLECKAKLFVETLHIT---K 2886
Query: 934 LQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXX 992
K+ E E KT EC+ SH V + W N EI + +I+ +G+
Sbjct: 2887 TMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE 2946
Query: 993 DVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERD 1052
D + + + S L V + L+D +EKD EV +N E W ++
Sbjct: 2947 DSAEYTFVCGNDQVSATLTVTPIM--ITSMLKDINAEEKDTITFEVTVNYEGISYKWLKN 3004
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR 1112
G IK +K + L IRN D +Y+ + + TA + V E
Sbjct: 3005 GVEIK-STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKH 3063
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+++ KV + +A FE E+++ D V+W KD E+Q ++ I++ + +L I + D
Sbjct: 3064 IKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3123
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
AG+Y+ G + TA L VE + + + + V A + E+ ++ +D WYK
Sbjct: 3124 AGKYTVVAGGNVSTAKLFVEGRDVRIR-SIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3182
Query: 1233 KSVI--EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
I + E+ + + + + I + + D EYT V +S+ L V E PP++
Sbjct: 3183 GIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPE-PPQV 3241
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
+ + ++ G PQP W +++ K D + +L + +
Sbjct: 3242 LQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEA 3301
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTI 1377
DA +Y +N+ G A ++++
Sbjct: 3302 FPEDAAVYTCEAKNDYGVATTSASLSV 3328
Score = 178 bits (434), Expect = 2e-43
Identities = 156/561 (27%), Positives = 249/561 (44%), Gaps = 26/561 (4%)
Query: 804 TLKAENSEGIAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
T+K E E S VI ++ T + P + + V E ++L +V+
Sbjct: 2324 TVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLES 2383
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
V + W ++ + + PS+ + D ++ L+I ++ E D+G+Y + G S+ G
Sbjct: 2384 VEGV-WMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKE-DAGNYSFTIP-ALGLSTSGRV 2440
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQE 978
V+ +T +K + EG +LEC+ S S KWY N ++I D + I +
Sbjct: 2441 SVYSVDVITPLKDVN----VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVK 2496
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
G D G K IV ET+ L V++ + IR L+D E + EV
Sbjct: 2497 GTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI--KIIRGLRDLTCTETQNVVFEV 2554
Query: 1039 EINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA 1098
E++ DV+W + IKP +KY E G I KL + N DEG+Y+ + +
Sbjct: 2555 ELSHSGIDVLWNFKDKEIKPS-SKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSG 2613
Query: 1099 EVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDG 1158
++TV I L +Q V + +A FE E+ D+ W +DG + +N+I+ DG
Sbjct: 2614 KLTVAG--GAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDG 2671
Query: 1159 KKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
K++L I LDD GEY+ +V SK +A L VE I TL+ + V DA TV
Sbjct: 2672 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLK---NLTVTETQDAVFTV 2728
Query: 1219 EIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
E+ + V W K V+E EK+ + +L I+ C D+ Y L ++
Sbjct: 2729 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASA 2788
Query: 1278 KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
+L VE V KI+ ++ + V V P + N +I KH S
Sbjct: 2789 RLHVETV----KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKHRLVS 2844
Query: 1338 IDSKSASLTIKKVENTDAGIY 1358
+ K L ++ + +DAG Y
Sbjct: 2845 -ERKVHKLMLQNISPSDAGEY 2864
Score = 178 bits (434), Expect = 2e-43
Identities = 153/697 (21%), Positives = 291/697 (41%), Gaps = 36/697 (5%)
Query: 1382 SPPGKPNILEIDSSS---INICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
+PPG P ++++ +S +++ W +P G II Y++E + D +W ++ + KT
Sbjct: 29179 NPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKT 29238
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI-TTEP 1495
+ ++ +L+ Y+FR A+N D+ E T K + ++ K
Sbjct: 29239 RYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRA 29298
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAF 1553
I L + G P P W + L T ++ Y
Sbjct: 29299 GASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVE 29358
Query: 1554 NDHGEVETSCVVGIQQKPVIT--ISNEDIKQKHKVGDEWLV--TAVIEGIPPPEVIWYKN 1609
N+ G + V + P I+ +D+ + G L+ +++G + Y
Sbjct: 29359 NNSGSKSITFTVKVLDTPGPPGPITFKDVTR----GSATLMWDAPLLDG--GARIHHYVV 29412
Query: 1610 GNKLENDKEYNITTKEKT-SVIRIKELKRSHSSKYTIEASNTAGTSS---VEVTLKVYDK 1665
+ + + + + +++ T + ++ +L + + A N G + + ++
Sbjct: 29413 EKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQ 29472
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P+ P ++ + S+ S + W P DGG +T Y +E + ++ W++ + T
Sbjct: 29473 PAPPRRLDVV-DTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQ--LT 29529
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
+ +++L E EY FRV A+N G+SE E+ ++IK P+ I ++
Sbjct: 29530 FTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAG 29589
Query: 1785 YITWFPSEKNGG-SPIIDYKVEIKQ--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+G +P + +K+E + E + ++ + ++ +
Sbjct: 29590 SPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTL 29649
Query: 1842 RNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
N G S + IG+ P + P VS ++ S L W EP+ GG+ ITNYI
Sbjct: 29650 ENTAGVKT--FSVTVVVIGRP-GPVTGP--IEVSSVSAESCVLSWGEPKDGGGTEITNYI 29704
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
+E + +W ++V + + ++ + E FR+S+EN GVS P ES + E
Sbjct: 29705 VEKRESGTTAW-QLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEH 29763
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
PS PT P E+ V +N + W P DGG+ ++GY + ++ +W++ KV
Sbjct: 29764 PFVPPSAPTRP-EVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPC 29822
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ + L E Y R YA N G+S+ E+ P
Sbjct: 29823 LECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRP 29859
Score = 178 bits (433), Expect = 2e-43
Identities = 212/908 (23%), Positives = 369/908 (40%), Gaps = 68/908 (7%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTW------YKKKSVIEDTEKFTLIS 1246
P L ++V A + V I +VTW K ++ IE+TE FTL
Sbjct: 21701 PDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTL-- 21758
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSD 1304
LII +C D ++ + + K + + V V++ P +++ R I + S
Sbjct: 21759 ------LIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNL-RPTDITKDS- 21810
Query: 1305 VTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL--TIKKVENTDAG---IYK 1359
VTL D P + + + I++K + T+ S + + KV G ++
Sbjct: 21811 VTLHWD---LPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFR 21867
Query: 1360 LRLENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
+ EN G + V + PSPP NI++I S++++ W +P++ G S I YV
Sbjct: 21868 VMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYV 21927
Query: 1417 VEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+E Q + +W + + + ++NL Y F+ AVN S E+ ++KE
Sbjct: 21928 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPV--IVKE 21985
Query: 1477 TKIQSPTVEKPL--KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRX 1533
+ + + K + + ++I++ G P+P VTW + + LK T + +E
Sbjct: 21986 QTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTA 22045
Query: 1534 XXXXXXX---XXXXXXXYKCIAFN---DHGEVETSCVVGIQQKPVITISNEDIKQKHKVG 1587
Y A N + G+V T V I P I +++ V
Sbjct: 22046 TSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDF-VT 22104
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
W G+P + + ++ + T + + L ++ ++A
Sbjct: 22105 FSWDPPENDGGVPISNYV--VEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKA 22162
Query: 1648 SNTAG-----TSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYA 1702
N G TS+ V + P P P + ++++S+TI W PL DGG + Y
Sbjct: 22163 QNRYGVGPGITSACIVANYPFKVPGPPGTPQV-TAVTKDSMTISWHEPLSDGGSPILGYH 22221
Query: 1703 IEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIK 1761
+E+ E + W V+ + L + Y FRVIA+N G S+ + SEP++
Sbjct: 22222 VERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLAL 22281
Query: 1762 TALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGKKWKXXXXX 1819
+D P I +V + W E GG I Y VE + G+ K
Sbjct: 22282 DPIDPPG----KPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSN 22337
Query: 1820 XXXXA-RIQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKTLTPPSQPRNFVVSES 1877
+ L+ + Y+FR+ A+N G S P D IT + P + ++
Sbjct: 22338 ILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDT 22397
Query: 1878 TSRSVTLKW-TEPESNGGSPIT-NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
+ E + +G P T + + K ++G + +I S + ++ +D
Sbjct: 22398 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN-LVNKDSTRRDS 22456
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
+ ++A N G + + V L++ P PP PL + V S + SW P DGG
Sbjct: 22457 GAYTLTATNPGGFAKHIFNVKV-LDR----PGPPEGPLAVTEVTSEKCVLSWFPPLDDGG 22511
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
A + Y + R+ ++ W V +V K + L + + Y+ R+ A N+ G+ EPLES
Sbjct: 22512 AKIDHYIVQKRETSRLAWTNVAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLES 22570
Query: 2056 DEPFKVIP 2063
+ V P
Sbjct: 22571 EPVLAVNP 22578
Score = 177 bits (432), Expect = 3e-43
Identities = 242/1060 (22%), Positives = 407/1060 (38%), Gaps = 87/1060 (8%)
Query: 645 VDEGSDILLECRLVAIPE-PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG+ +LEC+ V++P+ + W E+I PD+ + ++ L I
Sbjct: 2456 VIEGTKAVLECK-VSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQR----LVINRTHAS 2510
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
EG Y ++ E +L + KIK +I L+ + + ++V+ ++ +
Sbjct: 2511 DEGPYKLIVGRVETNCNLSVE-KIK--------IIRGLRDLTCTETQNVVFEVEL-SHSG 2560
Query: 764 PTITWC---KNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+ W K KP ++ G + +T+L K DEG YT A E I TS +
Sbjct: 2561 IDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMK-DDEGKYTFYA--GENI--TSGKL 2615
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV PL + TV E V NP W R+ + + + I
Sbjct: 2616 TVAGGA---ISKPL-----TDQTVAESQEAVFECEVA-NPDSKGEWLRDGKHLPLTNNIR 2666
Query: 881 QNFDGENIELVI--TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
DG L+I T +D +I YK S ++ K + VE V K L+
Sbjct: 2667 SESDGHKRRLIIAATKLD-DIGEYTYKVATSKTSAK--------LKVEAVKIKKTLKNLT 2717
Query: 939 ETEEGKTVI-LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
TE V +E + +W N + + I +G D V
Sbjct: 2718 VTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVY 2777
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
+ S L V ET+ + I+K +D E EV ++ +T V W IK
Sbjct: 2778 GFRLGRLGASARLHV-ETV-KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIK 2835
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
P +K+ + KL ++N S D GEY+ ++ C A++ V L I ++N +
Sbjct: 2836 PS-DKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL--HITKTMKNIE 2892
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + A+FE E++ + W K+G EI+ S ++ + GK +L I + +D+ EY+
Sbjct: 2893 VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT 2952
Query: 1178 CEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE 1237
GN + +A LTV I T L + +T + V + E + W K I+
Sbjct: 2953 FVCGNDQVSATLTVTP--IMITSMLKDINAEEKDTITF-EVTVNYEGISYKWLKNGVEIK 3009
Query: 1238 DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV--VEFPPKIVDYER 1295
T+K + + +L IR D +YT V A ST L VE +EF I D +
Sbjct: 3010 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDI-K 3068
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDA 1355
KR + + P +W+ + + ++ K + L I +DA
Sbjct: 3069 VLEKKRAMFECEVSE----PDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 3124
Query: 1356 GIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
G Y + N A + + + S + ++E + + +E + +
Sbjct: 3125 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 3184
Query: 1416 VVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+ +Q + +++ + I + S Y F A + S T Y
Sbjct: 3185 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGR-------NRSSVTLYVNAP- 3236
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENR 1532
+ P V + L+ +T + + + G PQPK++WY++ + L T K ++ +
Sbjct: 3237 ----EPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQ 3292
Query: 1533 XXXXXXXXXX-XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A ND+G TS + ++ V++ E +
Sbjct: 3293 EYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQ 3352
Query: 1592 VTAVIEGIPPP----------EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
T EG P +V WY K++ + + +T E T + I E
Sbjct: 3353 DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 3412
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRE 1681
YT ASN G S L + + P I +EI E
Sbjct: 3413 TYTFVASNAVGQVSSTANLSL-EAPESILHERIEQEIEME 3451
Score = 176 bits (429), Expect = 6e-43
Identities = 155/678 (22%), Positives = 278/678 (41%), Gaps = 27/678 (3%)
Query: 712 AVNREGEASLPIVLKIK---TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
A+ EG+ ++P K + E P++ E ++S V QG +VVG P P W
Sbjct: 2052 ALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEW 2111
Query: 769 CKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
KN ++ + D +++ +D +KA N G + A + V+
Sbjct: 2112 YKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA- 2170
Query: 826 TEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
+ F Q++ KEK T+ T P + WY++ + + + D
Sbjct: 2171 ----KQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDR 2226
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+ L I +D+ D+ DY CV + A++ ++ V FVK LQ E E +
Sbjct: 2227 KVHFLSILTIDTS-DAEDYSCVLVEDENVKT-TAKLIVEGAVVEFVKELQ-DIEVPESYS 2283
Query: 946 VILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ 1004
LEC S + KWYHN E+ I D G ++ +
Sbjct: 2284 GELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK 2343
Query: 1005 ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY- 1063
+T+ L +K ++ L D +V E D+ LEV+++ E+ + VW +DG+ ++P +
Sbjct: 2344 KTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHI 2403
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
+K+ H+ L I + + D G YS + + V ++IT L++ V +G K
Sbjct: 2404 VIDKQSHM--LLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTK 2461
Query: 1124 ATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
A E +++ D V+W+ + +I+ + +Q + G KQ+L I D G Y VG
Sbjct: 2462 AVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGR 2521
Query: 1183 SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKF 1242
+ L+VE+ I LR + + VE+ +DV W K I+ + K+
Sbjct: 2522 VETNCNLSVEKIKIIRGLR---DLTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKY 2578
Query: 1243 TLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
+ + K L + +DD+ +YT + ++ KL V + D +
Sbjct: 2579 KIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAGGAISKPLTD----QTVAES 2634
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
+ + A P EW+ + K + + + D L I + D G Y ++
Sbjct: 2635 QEAVFECEV-ANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKV 2693
Query: 1363 ENNCGHADVEMNVTILDK 1380
+ A +++ + K
Sbjct: 2694 ATSKTSAKLKVEAVKIKK 2711
Score = 176 bits (429), Expect = 6e-43
Identities = 171/705 (24%), Positives = 309/705 (43%), Gaps = 56/705 (7%)
Query: 632 IPPTFSKKPKAQYVD-EGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
IPP+F+K+ + EG+ LE R+ +AW EI P N + +++
Sbjct: 9174 IPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNT-- 9231
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
VL++ G YT N G A + IK K+PP + L + V +GE
Sbjct: 9232 --LVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKE-PKKPPVFDQHLTPVTVSEGE 9288
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAE 808
V LS V G+ I W K + +K S +L+ + V D G Y KA
Sbjct: 9289 YVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKAS 9348
Query: 809 NSEGIAETSAVITVEE-----PTEENAEPP---LFINRFQEITVKEKGTIKLVARVTRNP 860
N G T + +T+++ P + A F++ Q I V EK T +A+V +P
Sbjct: 9349 NVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDP 9408
Query: 861 VPSITWYRNN-EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
+P++ W + ++ + + G+ +L I + ++ DSG Y+CVA N G+
Sbjct: 9409 IPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDT-TKTDSGLYRCVAFNEHGEIESNV 9467
Query: 920 RVTIDV----EKV-----TFVKH--LQKSYETEEGKTVILECQTSHTVSTKWYHNKKEIS 968
+ +D EK+ +K + K EE + I+E + V K Y +
Sbjct: 9468 NLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKN--VDPKEYEKYARMY 9525
Query: 969 GM-DHREIIQEGRXXXXXXXXXXXX-DVGVIKCIVKDQETSTMLV------VKETIP-EF 1019
G+ D R ++Q ++ I+ +D++ LV + +T P
Sbjct: 9526 GITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTEPVTL 9585
Query: 1020 IRKLQDFEVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
I+ +++ V + + A+ E++I N + W + E ++P +K++ G L ++
Sbjct: 9586 IKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPS-DKFEISIDGDRHTLRVK 9644
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALV 1137
N + D+G Y + +A++TV+E P LQ+ + +G T + + +
Sbjct: 9645 NCQLKDQGNYRLVCGPHIASAKLTVIE--PAWERHLQDVTLKEGQTCTMTCQFSVPNVKS 9702
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSIN 1197
WF++G ++ + ++ K KL I D +D G+Y+C+ + + +A L +E I
Sbjct: 9703 EWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQ 9762
Query: 1198 FTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRK 1257
FT R+ + I+V + A E+ + VTWYK + + +++K+ +D + + I
Sbjct: 9763 FTKRI-QNIVVSEHQSATFECEVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHN 9821
Query: 1258 CTEDDQCEYTCVLL-----DAKSTTKLKVEVVEF-----PPKIVD 1292
T DD+ Y+ + +A+ST +L + E PP I D
Sbjct: 9822 VTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLELKPPDIPD 9866
Score = 174 bits (424), Expect = 3e-42
Identities = 197/865 (22%), Positives = 337/865 (38%), Gaps = 48/865 (5%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVV 1284
VTW KK+ T+ ++ V + L IR +D Y+ + + T +KV V+
Sbjct: 18177 VTW-KKEDRDAPTKARIDVTPVGSK-LEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVL 18234
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
+ P D E K +T ++V + + + + S SK S
Sbjct: 18235 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKS 18294
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL---EIDSSSIN 1398
K + + ++++ EN G + + LD PPG P L ++D + ++
Sbjct: 18295 HFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVS 18354
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
+ W++P+ G S I Y+VEYQE T +WI K +T + + L+ +YRFR A N
Sbjct: 18355 LVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENI 18414
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVE---KPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
V + +TT + + K+ P+VE K ++ + + + I GVP P W
Sbjct: 18415 VGLG-LPDTT--IPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKW 18471
Query: 1516 YRDGKKLKTAK-ATYENRXXXXXXXX---XXXXXXXYKCIAFNDHGEVETS---CVVGIQ 1568
DG ++KT + T E Y+ N G + V+ +
Sbjct: 18472 TTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVP 18531
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I+ D+ +H + W G P I K + D +++ +
Sbjct: 18532 GPPTGPINILDVTPEH-MTISWQPPKDDGGSPVINYIVEKQDTR--KDTWGVVSSGSSKT 18588
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGT----SSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
++I L++ + + A N G S K P P G ++ +I+ + T
Sbjct: 18589 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 18648
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
+ W P DGG +T Y +E+ E +W++V + + L E Y FRV A+
Sbjct: 18649 VSWTLPKSDGGSPITGYYMERREV-TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAE 18707
Query: 1745 NPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G S+ + S+PI + P E+ + W +GGSPI+ Y
Sbjct: 18708 NLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYV 18766
Query: 1804 VEIKQEG-KKWKXXXXXXXX---XARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
VE ++ G +W R+ L Y+FRI A N +G P + +
Sbjct: 18767 VECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIA 18826
Query: 1860 GKTLTPPSQPRNFVVSESTSRSV--TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT 1917
L PP + + + V T++ P + E K + + ++
Sbjct: 18827 KDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQ 18886
Query: 1918 VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM 1977
V E I+ D + ISA+N+ G +Q + P P L++
Sbjct: 18887 DLPRV-ELQIKEAVRADHGKYIISAKNSSG-----HAQGSAIVNVLDRPG-PCQNLKVTN 18939
Query: 1978 VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTY 2037
V SW P +GG+ + + + R + W V DV T + +L N+ Y
Sbjct: 18940 VTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVAS-DV-TKRLIKANLLANNEY 18997
Query: 2038 MIRIYARNEIGLSEPLESDEPFKVI 2062
R+ A N++G+ +E+ P I
Sbjct: 18998 YFRVCAENKVGVGPTIETKTPILAI 19022
Score = 171 bits (415), Expect = 3e-41
Identities = 164/708 (23%), Positives = 296/708 (41%), Gaps = 36/708 (5%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKT 1436
+D P PPGKP + ++ +S+ + W +PE+ G + I YV+E + T EW+ V + + T
Sbjct: 14908 IDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTT 14967
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNIT-TEP 1495
Q + L Y FR AVN+ S+ SE ++ V+ K+ P+ + L+ I T+
Sbjct: 14968 QHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSD--PVLCREKLYPPSPPRWLEVINITKN 15025
Query: 1496 NEDIELTCIF--GGVPQPK-VTWYRDGKKL------KTAKATYENRXXXXXXXXXXXXXX 1546
D++ T GG P + RD ++ T K T
Sbjct: 15026 TADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVA 15085
Query: 1547 XYKCIAFNDHGEVETSCVVG---IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE 1603
I +D+ E+E S + P ++ D+ ++H V +W G P
Sbjct: 15086 AENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRH-VDLKWEPPKNDGGRPIQR 15144
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT---SSVEVTL 1660
+ K +L T R+ ++ ++ + A N AG S L
Sbjct: 15145 YVIEKK-ERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEIL 15203
Query: 1661 KVYDKPSKPEGPVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
+ D S P P+ + + R+ + I WKPP +GG + Y +E +W++V
Sbjct: 15204 SIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNS 15263
Query: 1719 VD-RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXX 1776
+D++ + + + EY+ RV A N +G SE E SE +V K P+
Sbjct: 15264 RPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDI 15323
Query: 1777 XXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQ-KLSINTTY 1835
I+ E + I P + P + + + K+ + A ++ S+
Sbjct: 15324 IVIEGEKLSIP-VPF-RAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADA 15381
Query: 1836 Q-FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
+ I N++G++ T+ + K + P ++ S+ T S L W PE +GG
Sbjct: 15382 GIYTITLENKLGSA---TASINV---KVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGG 15435
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
+PI +Y++E + +++ +++ G + ++++ E FR+ A N VG E
Sbjct: 15436 TPILHYVLERREAGRRTYIPVMS-GENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIEL 15494
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
++ + + P P +E+ + + +W P +DGG+ ++GY I + W
Sbjct: 15495 KNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWK 15554
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVI 2062
+ V L + + L E Y R+ A N G+SEP + P K +
Sbjct: 15555 RCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAV 15602
Score = 166 bits (404), Expect = 7e-40
Identities = 246/1096 (22%), Positives = 440/1096 (40%), Gaps = 86/1096 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P ++ ++Q V +GSD R+V P+P+ W G +I + I D C
Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPED--NVCE 2135
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
L I +V + V A+N GE S L ++ K+ + L+ ++ ++ +++
Sbjct: 2136 -LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA--KQLITFTQELQDVVAKEKDTMA 2192
Query: 754 LSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
P + W K+ V SD H ++IL D Y+
Sbjct: 2193 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSIL-TIDTSDAEDYSCVLVED 2251
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
E + +T+A + VE E F+ Q+I V E + +L V+ + WY N+
Sbjct: 2252 ENV-KTTAKLIVEGAVVE------FVKELQDIEVPESYSGELECIVSPENIEG-KWYHND 2303
Query: 871 -EIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
E+ S + TIT +N L + +V E D G+Y V GK + ++ + +
Sbjct: 2304 VELKSNGKYTITSRRGRQN--LTVKDVTKE-DQGEYSFVID---GKKT-TCKLKMKPRPI 2356
Query: 929 TFVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
++ L + EG V LE + S +V W + +E+ D I+ + +
Sbjct: 2357 AILQGL-SDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIE 2415
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
D G + ST V + I L+D V E A+LE +++ +
Sbjct: 2416 DMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTS 2475
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELP 1106
V W + E IKP ++ +G ++L I T DEG Y I+ ++V ++
Sbjct: 2476 VKWYLNDEQIKP-DDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI- 2533
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVRW-FKDGSEIQFSNHIQLTIDGKKQKLKI 1165
+II L++ + FE+EL+ V W FKD EI+ S+ ++ GK KL +
Sbjct: 2534 -KIIRGLRDLTCTETQNVVFEVELSHSGIDVLWNFKD-KEIKPSSKYKIEAHGKIYKLTV 2591
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
+ DD G+Y+ G + + LTV +I+ L V + +A E+ +
Sbjct: 2592 LNMMKDDEGKYTFYAGENITSGKLTVAGGAISKPLTDQ---TVAESQEAVFECEVANPDS 2648
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
W + + T SD KR LII DD EYT + +K++ KLKVE V
Sbjct: 2649 KGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAV- 2707
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
KI + + D V+ +WI N +++ + S+ SL
Sbjct: 2708 ---KIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSL 2764
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEM-NVTILDKPSPPGKPNILEIDSSSINICWDEP 1404
IK D +Y RL A + + V I+ KP ++ ++++++
Sbjct: 2765 RIKNCAIVDESVYGFRLGRLGASARLHVETVKIIKKPK-----DVTALENATVAFEVSVS 2819
Query: 1405 ENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDA 1464
+T + VE + D +S + + K +QN+ + + + A V +++
Sbjct: 2820 HDTVPVKWFHKNVEIKPSDKHRLVSERKVHKLM--LQNISPSDAGEYTA-VVGQLECK-- 2874
Query: 1465 SETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
K+ ET + K +KNI + C P + W ++G +++
Sbjct: 2875 ------AKLFVETL----HITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEM 2923
Query: 1525 A---KATYENR-XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDI 1580
+ K + + Y + ND +V + V +IT +DI
Sbjct: 2924 SEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGND--QVSATLTV---TPIMITSMLKDI 2978
Query: 1581 KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHS 1640
+ K + VT EGI W KNG ++++ + + TK+ T + I+ + +
Sbjct: 2979 NAEEKDTITFEVTVNYEGI---SYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDA 3035
Query: 1641 SKYTIEASNTAGTSSVEVTLKVYD--------KPSKPEGPVIMREISRESVTIEWKPPLD 1692
+ YT A T+++ V + + K + + + E+S +T++W D
Sbjct: 3036 ADYTFVAGKATSTATLYVEARHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMK--D 3093
Query: 1693 DGGLELT-KYAIEKHE 1707
D L++T + I+K +
Sbjct: 3094 DQELQITDRIKIQKEK 3109
Score = 165 bits (401), Expect = 2e-39
Identities = 188/777 (24%), Positives = 330/777 (42%), Gaps = 67/777 (8%)
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
+P+ EWIV + ++ CK+ S+T K +E + ++++R EN G ++
Sbjct: 15772 KPDSEWIVVTSTLRHCKY----------SVT-KLIEGKEY-LFRVRAENRFGPGPPCVSK 15819
Query: 1376 TILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV 1430
++ K P P KP + ++ S+S+ + W+EP++ G S I+ Y +E +E+++T W V
Sbjct: 15820 PLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNG-SPILGYWLEKREVNSTHWSRV 15878
Query: 1431 KN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL 1488
+ + ++ L +Y FR A N S ++ P + +
Sbjct: 15879 NKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVT 15938
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXX 1544
+T + E GG ++ Y K+L + ++ T +
Sbjct: 15939 DTSSTTIELEWEPPAFNGG---GEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIRE 15995
Query: 1545 XXXYKC--IAFNDHGEV---ETSCV-VGIQQKPVITISNEDIKQKHKV--GDEWLVTAVI 1596
YK A N GE ET V V Q+P + +K ++ G + AV+
Sbjct: 15996 GADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVV 16055
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
G P P +W K +L+ D+ K+ +I IK+ R +Y I A+N+ G+
Sbjct: 16056 TGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELI-IKDALRKDHGRYVITATNSCGSKFA 16114
Query: 1657 EVTLKVYDKPSKPEGPVI-MREI--SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW 1713
++V+D P GPV+ ++ + +R+ + W P DDGG E+T + IE+ + + W
Sbjct: 16115 AARVEVFDVP----GPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTW 16170
Query: 1714 IKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
+ + +R + C I L E EY FRVIA+N G +E PI+ L P+
Sbjct: 16171 RQPIETER---SKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPER 16227
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK---KWKXXXXXXXXXARIQKL 1829
++ + W NGGSPI Y +E ++ K + ++ L
Sbjct: 16228 LTYTER-TKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENL 16286
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP 1889
+ Y+FR+ A NEIG S P + + + P + R V ++ P
Sbjct: 16287 DEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIP 16346
Query: 1890 ESNGGSPI-------TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
G P+ +IE T + + V+ + E I +D+ + ++A
Sbjct: 16347 ADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTA 16406
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
N +G + ++V +E + PSPP L + + + +W P +GG+ + Y
Sbjct: 16407 SNRLG----SVFRNVHVEVYDR-PSPP-RNLAVTDIKAESCYLTWDAPLDNGGSEITHYV 16460
Query: 2003 IAIRDVT--KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
I RD + K W EV V ++ I L N Y R+ A N+ G+S+ +SD+
Sbjct: 16461 IDKRDASRKKAEWEEVTNTAVEK-RYGIWKLIPNGQYEFRVRAVNKYGISDECKSDK 16516
Score = 163 bits (395), Expect = 8e-39
Identities = 179/733 (24%), Positives = 293/733 (39%), Gaps = 51/733 (6%)
Query: 1358 YKLRLENNCGHADVEMN---VTILDKPSPPGKP-NILEIDSS--SINICWDEPENTGNST 1411
++++ EN G + + V D PPG P N +D++ SI + W +P G +
Sbjct: 19395 FRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP 19454
Query: 1412 IIYYVVEYQE--IDTTE---W---ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISD 1463
II YVVE + D + W + + + + ++ +L N Y FR A N+V I
Sbjct: 19455 IIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGR 19514
Query: 1464 ASETTEYYKVIKETKIQSPTVE---KPLKNITTEPNEDIELTCIFGGVPQPKVTWYR--- 1517
+E E K KE ++ P ++ K + I L I G P PKVTW +
Sbjct: 19515 PAELKEAIKP-KEI-LEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGI 19572
Query: 1518 DGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK--PVITI 1575
D K + Y N GE V + PV +
Sbjct: 19573 DNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL 19632
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKE 1634
D+ K W A E +V Y + + K ++ T E K + +
Sbjct: 19633 KVSDV-TKTSCHVSW---APPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTN 19688
Query: 1635 LKRSHSSKYTIEASNTAG---TSSVEVTLKVYDKPSKPEGP--VIMREISRESVTIEWKP 1689
L + + + A N G + V + D S+P+ P + + E+++ S T+ W P
Sbjct: 19689 LVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLP 19748
Query: 1690 PLDDGGLELTKY--AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PL DGG ++ Y + + E +RW + + V +D+ + + L E +Y FRV A+N V
Sbjct: 19749 PLRDGGAKIDGYITSYREEEQPADRWTEYS-VVKDL-SLVVTGLKEGKKYKFRVAARNAV 19806
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S E+E + +P + + I K P +K
Sbjct: 19807 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGK--PHPTCKWKKGED 19864
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ I+ ++ + + + A N GT T K+ + P
Sbjct: 19865 EVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTD---TQKIKVVVMDAPGP 19921
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P F +S+ + + +L W P +GGS ITNYI+E V W + +
Sbjct: 19922 PQPP--FDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDW--VTALASVTKTS 19977
Query: 1926 C-IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVM 1984
C + + E IFR+ AEN G+S P S + + VPS P + V + +
Sbjct: 19978 CRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEP-KNARVTKVNKDCIF 20036
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
+W P+ DGG+P++GY I ++ +W++ V + ++ L E Y RIYA
Sbjct: 20037 VAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYAL 20096
Query: 2045 NEIGLSEPLESDE 2057
N+ G S P + E
Sbjct: 20097 NKAGSSPPSKPTE 20109
Score = 162 bits (393), Expect = 1e-38
Identities = 159/704 (22%), Positives = 283/704 (40%), Gaps = 35/704 (4%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITK 1435
+++PSPP + SS+ + W+ P G S I+ Y++E E WI ++K + +
Sbjct: 14216 IERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPE 14275
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTE- 1494
+ L+ + Y +R A N+ +SD SE + + PT++ E
Sbjct: 14276 LTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILG--PLTADDAFVEPTMDLSAFKDGLEV 14333
Query: 1495 --PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIA 1552
PN I + G P+P TW K L+T K I
Sbjct: 14334 IVPNP-ITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGI- 14391
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE-----VIWY 1607
+ E + G + V I+ ++ K GD + + PP + + Y
Sbjct: 14392 YTLKLENRVKTISG--EIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGY 14449
Query: 1608 KNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTSS---VEVTLKVY 1663
+ + K + T + + +L + + + A N G V+ + +
Sbjct: 14450 VVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMS 14509
Query: 1664 DKPSKPEGP--VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
+ P+ P V R+ + S+ + W PP +DGG + Y +E+ +++W+ +
Sbjct: 14510 TPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVA 14569
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXID 1780
+ + + L E Y +RV A N G S+ + +E I + P +
Sbjct: 14570 ETKME-VTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLT 14628
Query: 1781 NESVYITWFPSEKNGG-SPIIDY-KVE-IKQEGKKWKXXXXXXXXXARIQKLSINTTYQF 1837
++ P+ G P I + K + I ++ K+ I + T +
Sbjct: 14629 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 14688
Query: 1838 RIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPI 1897
I A N G + T+ ++ + L P P F +++ T+ S L W P +GGS I
Sbjct: 14689 IIEAVNVCGRA---TAVVEVNV---LDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKI 14742
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
TNY++E + + W K+ + + + I K E IFR++AEN GV P ++ +
Sbjct: 14743 TNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNK-EYIFRVAAENMYGVGEPVQASPI 14801
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
+ P PPT LE + + V +W P+ DGG+P+ GY + D W+
Sbjct: 14802 TAKYQFDPPGPPTR-LEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCN 14860
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
K+ V + ++ L+ Y R+ A N G +P +S EP +
Sbjct: 14861 KMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILI 14904
Score = 161 bits (391), Expect = 2e-38
Identities = 238/1087 (21%), Positives = 450/1087 (41%), Gaps = 84/1087 (7%)
Query: 629 LEGIPPTFSKKPKAQYVDE----GSDILLECRLVAIPEPDIAWLFKGEEIVPD-ENISVA 683
L+ +P F K+ K + E GS + EC LV+ W+ G I ++ +A
Sbjct: 12037 LKAVPLKFVKEIKDIILTESEFVGSSAIFEC-LVSPSTAITTWMKDGSNIRESPKHRFIA 12095
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAV--NREGEASLPIVLKIKTGEKEPPQVIEPL 741
D ++ I +V+ G YT V N+E ++ +V+ E+ P + ++ L
Sbjct: 12096 DGKDRKLH-----IIDVQLSDAGEYTCVLRLGNKEKTSTAKLVV-----EELPVRFVKTL 12145
Query: 742 KSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD----GDTHSITILKPKK 796
+ + V +G+ + LS ++ N + W K+ K V P + G ++TI
Sbjct: 12146 EEEVTVVKGQPLYLSCEL--NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADD 12203
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D G YT+ EN+ + +S V VE + +P ++ VK KGT +
Sbjct: 12204 T-DAGTYTVTVENANNLECSSCVKVVEVIRDWLVKP------IRDQHVKPKGTAIFACDI 12256
Query: 857 TRNPVPSITWYRNNEII--SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
++ P+I W++ + I P++ DG ++ L I N E D +Y A GK
Sbjct: 12257 AKD-TPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPE-DIAEY---AVEIEGK 12311
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHR 973
+ A++T+ +V +K ++ E ++ + + S + +W + +
Sbjct: 12312 R-YPAKLTLGEREVELLKPIE-DVTIYEKESASFDAEISEADIPGQWKLKGELLRPSPTC 12369
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDV 1033
EI EG G + + T+ +L VKE +F L+D V E+
Sbjct: 12370 EIKAEGGKRFLTLRKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQ 12429
Query: 1034 AILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
A E + E A+V+W + +IIK +K+D G L I ++ DEG Y+ +
Sbjct: 12430 ARFECVLTRE-ANVIWSKGPDIIK-SSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEG 12487
Query: 1094 ESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
+ +A + V + + ++ L++Q V +G ATF EL+ V WFK+ +++ S +
Sbjct: 12488 KKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVL 12547
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTD 1213
++ +GK KL++ + LDD + +V TA L V E FT++L + V + +
Sbjct: 12548 ISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKD-E 12606
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
L E+ + + V W+K I + K+++ +D +R L I+K D+ EY C
Sbjct: 12607 ITLKCEV-SKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTD 12665
Query: 1274 KSTTKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLLVDYQ-AFPQPNDEWIVNSKIIKKC 1331
K+ + VE +++ E+ Y ++ T + + + P + +W + + +
Sbjct: 12666 KTKANVTVEA-----RLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTAS 12720
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
+ D K L + + G + N A++++ L +P + E
Sbjct: 12721 PDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVFE 12780
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS-VKNITKTQTSIQN--LKTNSS 1448
D + E E + ++ QEI + +K+ TK I++ + +
Sbjct: 12781 KDEAKF-----ECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAK 12835
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGV 1508
Y F A + T +I+ +++ T PLK++T + E T
Sbjct: 12836 YMFEA----------EDKHTSGKLIIEGIRLKFLT---PLKDVTAKEKESAVFTVELSH- 12881
Query: 1509 PQPKVTWYRDGKKLKTAKA-TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
+V W+++ ++L T ++ + ++ I G + + +
Sbjct: 12882 DNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVL 12941
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+ P T +D K DE ++ I P V W+K+G +++ K I K
Sbjct: 12942 EGDPYFTGKLQDYTGVEK--DEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKK 12998
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI-SRESVTIE 1686
++ +K+ +S +YT + GT L + D+ K P+ E+ E+ E
Sbjct: 12999 RMLILKKALKSDIGQYTCD----CGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFE 13054
Query: 1687 WKPPLDD 1693
+ DD
Sbjct: 13055 TEISEDD 13061
Score = 161 bits (390), Expect = 3e-38
Identities = 169/711 (23%), Positives = 284/711 (39%), Gaps = 48/711 (6%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK--NITK 1435
LD PPGKP L I ++ + W +PE TG I Y+VE +++ W+ NI +
Sbjct: 22281 LDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILE 22340
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVD-ISDASETTEYYKVIKETKIQSPTVEKPLK---NI 1491
+ ++ L +++Y FR A N IS SE ++ + +++P ++ +K +
Sbjct: 22341 NEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSD--AITCRDDVEAPKIKVDVKFKDTV 22398
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXX---XXX 1547
+ E L G P P + W +DGK+L+ TAK +
Sbjct: 22399 ILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGA 22458
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWY 1607
Y A N G + V + +P E +V E V+ PP +
Sbjct: 22459 YTLTATNPGGFAKHIFNVKVLDRPG---PPEGPLAVTEVTSE---KCVLSWFPPLDDGGA 22512
Query: 1608 KNGNKLENDKEY------NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-----SSV 1656
K + + +E N+ ++ + + +++ +L + + + + A N G S
Sbjct: 22513 KIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEP 22572
Query: 1657 EVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV 1716
+ + Y P P+ P + I+++S+ + W P DGG E+ Y +E+ + RWIK
Sbjct: 22573 VLAVNPYGPPDPPKNPEVTT-ITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKC 22631
Query: 1717 ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXX 1776
Y + L E EY FR++A+N G S + P
Sbjct: 22632 NKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV 22691
Query: 1777 XXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXAR---IQKLSIN 1832
S+ I W +GGS I Y VEI E +W+ A I L+ N
Sbjct: 22692 LDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTEN 22751
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES-TSRSV-TLKWTEPE 1890
Y+ RIYA N G P + PP + + + T R+ TL+ P
Sbjct: 22752 QEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPI 22811
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE-NIKEKDEIIFRISAENTVGVS 1949
+P + + G+S K S + I N+ D + ++ EN+ G
Sbjct: 22812 KGRPAPEVKWARDH----GESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSG-- 22865
Query: 1950 LPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVT 2009
++S V + T P PP L+++ V V +W P DGG+ + Y + R+ T
Sbjct: 22866 --SKSAFVNVRVLDT-PGPPQ-DLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKREST 22921
Query: 2010 KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
+ + V + + + + L E +Y R+ A NE G+ P E+ E K
Sbjct: 22922 RKAYSTVA-TNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVK 22971
Score = 160 bits (389), Expect = 4e-38
Identities = 192/881 (21%), Positives = 342/881 (38%), Gaps = 84/881 (9%)
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPK 1289
K V + E L + +II +C +Y+ + + T +V+V++ P
Sbjct: 16782 KDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGP 16841
Query: 1290 IVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-------WIVNSKIIKKCKHTKPSIDSKS 1342
D + SD+T ++ P+D+ +++ + I TK + D S
Sbjct: 16842 PKDL-------KVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGS 16894
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCG---HADVEMNVTILDK---PSPPGKPNILEIDSSS 1396
+ + + + +++R EN G + T D P PP K I I ++
Sbjct: 16895 TTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNT 16954
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTT-----EW--ISVKNITKTQTSIQNLKTNSSY 1449
+++ W P+N G S + +Y+VE D T W + +++ + Q ++++L Y
Sbjct: 16955 VHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEY 17014
Query: 1450 RFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNEDIELTCIFGGV 1508
FR AVN +S S T + P+++ LK + E ++ + GV
Sbjct: 17015 EFRVKAVNAAGVSKPSATVGPCDC--QRPDMPPSID--LKEFMEVEEGTNVNIVAKIKGV 17070
Query: 1509 PQPKVTWYR------DGKK-----LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG 1557
P P +TW++ D K+ K ++ Y A N+ G
Sbjct: 17071 PFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLG 17130
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK 1617
+ + +P + IK + D+ + PP + K N + +
Sbjct: 17131 TASKEMRLNVLGRPGPPVG--PIKFESVSADQ----MTLSWFPPKDDGGSKITNYVIEKR 17184
Query: 1618 EYN------ITTKEKTSVIRIKELKRSHSSKYTIEASNTAG-----TSSVEVTLKVYDKP 1666
E N ++++ K I +L H + I A N G S E ++ P
Sbjct: 17185 EANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVP 17244
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVE- 1724
P+ P + ++R S+T+ W+ P DGG +T Y +E + + RW +V D + +
Sbjct: 17245 GAPDKPTV-SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTL 17303
Query: 1725 --TYCIQKLNENCEYMFRVIAQNPVGFSEA-LESEPIVIKTALDVPSXXXXXXXXXXIDN 1781
+Y + L E +Y FRV A N G A L S+P + + P
Sbjct: 17304 GVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWT--K 17361
Query: 1782 ESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXAR--IQKLSINTTYQFR 1838
S + W P K+GGS + Y VE K+EGK +W+ + + L Y+FR
Sbjct: 17362 SSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFR 17421
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESNGGSP 1896
+ A N G P D I + L P + V + ++ S P
Sbjct: 17422 VSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPP 17481
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQS 1956
+ + +T+ ++ + + S+ I+N + + ++ + A+N G E +
Sbjct: 17482 TVTWNMNERTLPQEATIETTAISSSM---VIKNCQRSHQGVYSLLAKNEAG-----ERKK 17533
Query: 1957 VRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV 2016
+ VP P P + + +W +PE DGG+P+ Y I R+ + W V
Sbjct: 17534 TIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPV 17593
Query: 2017 GKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
V ++ L + Y RI A N IG+ +E+ E
Sbjct: 17594 -TYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSE 17633
Score = 159 bits (386), Expect = 1e-37
Identities = 115/396 (29%), Positives = 184/396 (46%), Gaps = 15/396 (3%)
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
D P +PE VI +R +VT++WK P DGG ++T Y +EK + + RW+K + +
Sbjct: 25531 DPPGRPEAIVI----TRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLE 25586
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVG-FSEALESE-PIVIKTALDVPSXXXXXXXXXXIDN 1781
+ + L E+ Y FRVIA+N G FSE +S I + +D P+ I
Sbjct: 25587 TEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVV 25646
Query: 1782 ESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ T+ G PI D V ++GK+ + + IQK ++ R
Sbjct: 25647 HAGE-TFVLEADIRGKPIPD--VVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 25703
Query: 1842 RNEIG--TSLPYTSDDKITIGKTLTPPSQPRN-FVVSESTSRSVTLKWTEPESNGGSPIT 1898
I +++ T IT+ K L P P V+ T+ L W P +GG+ I+
Sbjct: 25704 GQYILKLSNVGGTKSIPITV-KVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANIS 25762
Query: 1899 NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
+YIIE + SWT++ T +++ + + + +E IFR+ A N G+ P ES V
Sbjct: 25763 HYIIEKRETSRLSWTQVSTEVQALN-YKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVT 25821
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
P PP+ P E+ + + ++ +W P DGG + GY + RD W + K
Sbjct: 25822 ACNPYKPPGPPSTP-EVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNK 25880
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
+ L+ + L+E H+Y R+ A N G+ EP E
Sbjct: 25881 KTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSE 25916
Score = 158 bits (384), Expect = 2e-37
Identities = 122/395 (30%), Positives = 175/395 (44%), Gaps = 18/395 (4%)
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
D P +PE ++ +R SVT++WK P DGG ++T Y +EK E RW+K A +
Sbjct: 23367 DPPGRPEAIIV----TRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMK-ASFTNII 23421
Query: 1724 ETYC-IQKLNENCEYMFRVIAQNPVG-FSEALESE-PIVIKTALDVPSXXXXXXXXXXID 1780
+T+ + L E+ Y FRVIA+N G FSE ES I + +D P I
Sbjct: 23422 DTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIV 23481
Query: 1781 NESVYITWFPSEKNGGS-PIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRI 1839
+ ++ G P I + IK + + LS+ R+
Sbjct: 23482 VHAGESFKVDADIYGKPIPTIQW---IKGDQELSNTARLEIKSTDFATSLSVKDAV--RV 23536
Query: 1840 YARNEIGTSLPYTSDDKITIG-KTLTPPSQPRN-FVVSESTSRSVTLKWTEPESNGGSPI 1897
+ N I + + +T+ K L P P V+S T+ TL W P +GGS I
Sbjct: 23537 DSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDI 23596
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
NYI+E + WT +V + + E +E FRI A N GV P ES+ V
Sbjct: 23597 INYIVERRETSRLVWT-VVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPV 23655
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
+ VP P AP E+ V + ++ W P DGG+ +LGY + RD W
Sbjct: 23656 VAKNPFVVPDAPKAP-EVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCH 23714
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
K + L+ + L ENH Y R+ A N GLSEP
Sbjct: 23715 KRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEP 23749
Score = 156 bits (378), Expect = 9e-37
Identities = 106/368 (28%), Positives = 166/368 (45%), Gaps = 15/368 (4%)
Query: 1623 TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRES 1682
+K+ S +R+++ R Y I+ N G + T+ V D P P + +I + S
Sbjct: 15686 SKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTS 15744
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHE---PDNNRWIKVADVDRDVETYCIQKLNENCEYMF 1739
V +W+PPLDDGG E+ Y +EK + PD+ WI V R + Y + KL E EY+F
Sbjct: 15745 VLCKWEPPLDDGGSEIINYTLEKKDKTKPDSE-WIVVTSTLRHCK-YSVTKLIEGKEYLF 15802
Query: 1740 RVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
RV A+N G S+P+V K P N S+ + W K+ GSPI
Sbjct: 15803 RVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN-SMLVKW-NEPKDNGSPI 15860
Query: 1800 IDYKVEIKQ-EGKKWKXXXXXXXXX--ARIQKLSINTTYQFRIYARNEIGTSLPYTSDDK 1856
+ Y +E ++ W A + L TY FR+ A N G D
Sbjct: 15861 LGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 15920
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
T ++PP P V ++++S ++ L+W P NGG I Y ++ + V W++
Sbjct: 15921 KTAHDPISPPGPPIPRV-TDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCT 15979
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIR 1976
V ++ ++ I+E + R+SA N G P E+Q V + A PP L++
Sbjct: 15980 EKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTV---AEPQEPPAVELDVS 16036
Query: 1977 MVGSNIVM 1984
+ G +M
Sbjct: 16037 VKGGIQIM 16044
Score = 155 bits (377), Expect = 1e-36
Identities = 198/880 (22%), Positives = 337/880 (38%), Gaps = 48/880 (5%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA--KSTTKLKVEVV 1284
+TW K + D + S L + D +Y L ++ K + V+V+
Sbjct: 20652 ITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVL 20711
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
+ P V+ + K + VT P ++V + ++ + + + S
Sbjct: 20712 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 20771
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHAD---VEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
+ +E + +++ EN G D V P P + + SS +I W
Sbjct: 20772 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 20831
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDI 1461
+P + G S II YVV++ + +W V Q S ++L Y FR A NE
Sbjct: 20832 KKPHSDGGSRIIGYVVDFL-TEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGE 20890
Query: 1462 SDASETTEYYKVIKETKIQSPTVE-KPLKNI--TTEPNEDIELTCIFGGVPQPKVTWYRD 1518
SE T V+ + +P ++ K L ++ + N + L G P P V+W +
Sbjct: 20891 GTPSEIT----VVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKG 20946
Query: 1519 GKKLKT-AKATYENRXXXXXXXX---XXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT 1574
L T + + E+ Y N G E + + + KP I
Sbjct: 20947 EDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIP 21006
Query: 1575 IS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
D + +W G I K + N+K + + + R+
Sbjct: 21007 TGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDS--VNNKWVTCASAVQKTTFRV 21064
Query: 1633 KELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYDKPSKPEGPVIMREISRESVTIEW 1687
L + + A N G S V +D P P P I+ ++ +SV++ W
Sbjct: 21065 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIV-DVRHDSVSLTW 21123
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P GG +T Y +E E ++ W + + + + L E EY FRV+A N
Sbjct: 21124 TDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLA 21183
Query: 1748 GFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
G + +L SEP+V +D P I SV + W + +GG + Y VE
Sbjct: 21184 GVGKPSLPSEPVVALDPIDPPG----KPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEK 21239
Query: 1807 KQ-EGKKWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKT 1862
+ K W + L Y+FRI A+N G S P S + I
Sbjct: 21240 RDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDE 21299
Query: 1863 LTPPSQPRNFVVSES-TSRSVTLKWTEPESNGGSPI--TNYIIEFKTVKGKSWTKIVTVG 1919
P+ + + + T ++ S G P+ +++ K ++ T+I +
Sbjct: 21300 YEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTP 21359
Query: 1920 GSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVG 1979
S I+ KD + I+A N G T+ + V++ VP PP P+EI V
Sbjct: 21360 TS-SMLTIKYATRKDAGEYTITATNPFG----TKVEHVKVTV-LDVPGPP-GPVEISNVS 21412
Query: 1980 SNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMI 2039
+ +W P DGG+P+ Y + R+ ++ +W V + D+ + + L + + Y+
Sbjct: 21413 AEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSE-DIQSCRHVATKLIQGNEYIF 21471
Query: 2040 RIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
R+ A N G EP++S EP K++ G E E + V
Sbjct: 21472 RVSAVNHYGKGEPVQS-EPVKMVDRFGPPGPPEKPEVSNV 21510
Score = 155 bits (376), Expect = 2e-36
Identities = 180/814 (22%), Positives = 322/814 (39%), Gaps = 64/814 (7%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
K +D+ V + P +IV + +++ K T+ + +++
Sbjct: 15024 KNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFR 15083
Query: 1360 LRLENNCGHAD-VEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTII 1413
+ EN G +D E+ ++L K P PP ++++ +++ W+ P+N G I
Sbjct: 15084 VAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQ 15143
Query: 1414 YYVVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
YV+E +E T W+ + + ++ + +F+ A NE + SE TE
Sbjct: 15144 RYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEIL 15203
Query: 1472 KVIKETKIQSPTVEKPLKN-------ITTEPNEDIELTCIFGG----VPQPKVTWYR-DG 1519
+ T SP ++ + + I +P E + I G P W R +
Sbjct: 15204 SIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNS 15263
Query: 1520 KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ-KPVITISNE 1578
+ +K K E I ++ E+ + V KP I +
Sbjct: 15264 RPIKDLKFKVEE--GVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETH 15321
Query: 1579 DIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
DI G++ + +P P V W+K+G +++ + ++ + + + R+
Sbjct: 15322 DIIVIE--GEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRA 15379
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLEL 1698
+ YTI N G+++ + +KV P P + +I++ S + W+PP DGG +
Sbjct: 15380 DAGIYTITLENKLGSATASINVKVIGLPG-PCKDIKASDITKSSCKLTWEPPEFDGGTPI 15438
Query: 1699 TKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
Y +E+ E +I V + + ++ ++ L N EY FRV A N VG E +E +
Sbjct: 15439 LHYVLERREAGRRTYIPVMSGENKL-SWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNP 15497
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWK--X 1815
VI P E++ ITW P +GGS I+ Y +E I + ++WK
Sbjct: 15498 VIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCN 15557
Query: 1816 XXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-V 1874
+ L YQFR+ A N G S P + K + P P+ +
Sbjct: 15558 EHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPT---KAVDPIDAPKVILRT 15614
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYI-----IEFKTVKGKSWTKIVTVGGSVHEH---- 1925
S R + S P +I I + +K ++ + G V E
Sbjct: 15615 SLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFV 15674
Query: 1926 -------CIENIKE-KDEIIFRISAENTVGV-SLPTESQSVRLEKHATVPSPPTAPLEIR 1976
I+N K+ + ++ R S G+ + E+ + TV T I
Sbjct: 15675 LPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN 15734
Query: 1977 MVGSNI----VMTSWGTPEWDGGAPLLGYNIAIRDVTK--TMWMEVGKVDVNTLKFNIRD 2030
V +I V+ W P DGG+ ++ Y + +D TK + W+ V + K+++
Sbjct: 15735 FVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTST-LRHCKYSVTK 15793
Query: 2031 LSENHTYMIRIYARNEIG-----LSEPLESDEPF 2059
L E Y+ R+ A N G +S+PL + +PF
Sbjct: 15794 LIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPF 15827
Score = 153 bits (370), Expect = 9e-36
Identities = 116/432 (26%), Positives = 195/432 (45%), Gaps = 20/432 (4%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY--DKPSKPEGPVIMREISRESVTIEWK 1688
+ + L+ ++ + A N G + Y P P G + R +T++W
Sbjct: 24410 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWT 24469
Query: 1689 PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET-YCIQKLNENCEYMFRVIAQNPV 1747
P+ DGG +T Y +EK + + RW+K A +ET + + L E+ Y FRVIA+N
Sbjct: 24470 KPVYDGGSMITGYIVEKRDLPDGRWMK-ASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA 24528
Query: 1748 G-FSEALESE-PIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGS-PIIDYKV 1804
G S+ +S PI K +++P I + ++ +G P I++
Sbjct: 24529 GAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 24588
Query: 1805 EIKQEGKKWKXXXXXXXXXAR-IQKLSINTTY-QFRIYARNEIGT-SLPYTSDDKITIGK 1861
K+ + + A I K +I Q+ + A N G+ S P K
Sbjct: 24589 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNV-------K 24641
Query: 1862 TLTPPSQPRNFV-VSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG 1920
L P P V V+ TS +L W+ P +GGS I++Y++E + +WT +V
Sbjct: 24642 VLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLAWT-VVASEV 24700
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGS 1980
+ + + E +E +FRI A N GV P ES V ++ +P PP + LE+ +
Sbjct: 24701 VTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKS-LEVTNIAK 24759
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+ + W P+ DGG+ ++GY + RD + W++ K + L+ + L+E+H Y R
Sbjct: 24760 DSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFR 24819
Query: 2041 IYARNEIGLSEP 2052
+ A N G+ EP
Sbjct: 24820 VSAENAAGVGEP 24831
Score = 151 bits (367), Expect = 2e-35
Identities = 176/756 (23%), Positives = 297/756 (39%), Gaps = 41/756 (5%)
Query: 940 TEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD-VGVIK 998
+EEG V L ++ WY K + + + +Q+ D G
Sbjct: 4300 SEEGDIVHLTTSITNAKEVNWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYV 4359
Query: 999 CIV-----KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERD 1052
C K ++ + VVK P RK++ EV +A EI S W +
Sbjct: 4360 CEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKA 4419
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----SCTAEVTVVE-LPP 1107
G I + +K +I L I T V D GEY+C +E SCTA +TV E PP
Sbjct: 4420 GREIY-ESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPP 4478
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
++R ++ G A F +T G ++ W KDG+ + S + +++ K L++
Sbjct: 4479 TFLSRPKSLTTFVGKAAKFICTVT-GTPVIETIWQKDGAALSPSPNWKISDAENKHILEL 4537
Query: 1166 YDCDLDDAGEYSCEVGN----SKCTA-ILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+ + D G YSC+ N C A ++ +++P +F L E + N +L ++
Sbjct: 4538 SNLTIQDRGVYSCKASNKFGADICQAELIIIDKP--HFIKEL-EPVQSAINKKVHLECQV 4594
Query: 1221 -PDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
D + VTW K + + + + + K TL I D Y C + ++
Sbjct: 4595 DEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSC 4654
Query: 1280 KVEV-VEFPPKIV-DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V V PP V + Y + G L + P W N+K + + +
Sbjct: 4655 SATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMY 4714
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
+ A L I V+ D+G Y N+ G + I + PS +I +
Sbjct: 4715 FVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTN 4774
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVN 1457
+ E TG I ++ + ++I + S K +Q S+ L+ + F + V
Sbjct: 4775 ALLQCEVSGTGPFEISWF-KDKKQIRS----SKKYRLFSQKSLVCLEI---FSFNSADVG 4826
Query: 1458 EVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
E + A+E + + + PT K + ++ + + L G VTW +
Sbjct: 4827 EYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMK 4886
Query: 1518 DGKKLK---TAKATYENRXXXXXX-XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
+ ++ K ++ N Y C+A N+ G +TS I ++P
Sbjct: 4887 GQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS-QTSVGELIVKEPAK 4945
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
I ++ Q GD + + G P + WYK+G L K+Y I+ K + ++
Sbjct: 4946 IIERAELIQV-TAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFY 5004
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
+ S +YT E SN G+SS E T V D+ P
Sbjct: 5005 SAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAP 5040
Score = 150 bits (363), Expect = 6e-35
Identities = 198/893 (22%), Positives = 344/893 (38%), Gaps = 49/893 (5%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVK 1249
+E P I+ + + ++V A L + VTW +K I++ + + V
Sbjct: 19528 LEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTW--RKVGIDNVVRKGQVDLVD 19585
Query: 1250 KRT-LIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
L+I T DD +Y+ L++ + + V V++ P + D + K V+
Sbjct: 19586 TMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVS 19645
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
+IV + + + + + K S + + + +++ N
Sbjct: 19646 WAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEY 19705
Query: 1367 GHA---DVEMNVTILD---KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
G DV V D +P PP K + E+ +S + W P G + I Y+ Y+
Sbjct: 19706 GPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYR 19765
Query: 1421 EID--TTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK 1478
E + W + + LK Y+FR A N V +S E Y+ KE +
Sbjct: 19766 EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA-KE-Q 19823
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATY--ENRXX 1534
+ P + P + IT + + + + G P P W + ++ T+ A + ++
Sbjct: 19824 LLPPKILMP-EQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI 19882
Query: 1535 XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK--QKHKVGDEWLV 1592
Y A N G V + P DI W +
Sbjct: 19883 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHI 19942
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
G I + + D + + KTS R+ +L + + A N G
Sbjct: 19943 PLEDGGSNITNYI-VEKCDVSRGDWVTALASVTKTS-CRVGKLIPGQEYIFRVRAENRFG 20000
Query: 1653 TSSVEVTLKV-----YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
S + K+ + PS+P+ + + ++++ + + W P DGG + Y IE+ E
Sbjct: 20001 ISEPLTSPKMVAQFPFGVPSEPKNARVTK-VNKDCIFVAWDRPDSDGGSPIIGYLIERKE 20059
Query: 1708 PDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP 1767
++ W+K D Y L E EY FR+ A N G S S+P TA +P
Sbjct: 20060 RNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSP--PSKPTEYVTA-RMP 20116
Query: 1768 SXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWKXXXXXXXXXARI 1826
+ +V + W + +GGS II Y VE K G KW +
Sbjct: 20117 VDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQE 20176
Query: 1827 Q----KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVV-SESTSRS 1881
+ L YQFR AR + S P D +TI PP + + S T ++
Sbjct: 20177 EYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKA 20236
Query: 1882 VTLKWTEPESNG-GSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
T + G P ++ + +K K + + ++ + ++ KD + I
Sbjct: 20237 GTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIK-MAMQRNLCTLELFSVNRKDSGDYTI 20295
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
+AEN+ G ++S +++L K P PP A ++I + S+ M SW P DGG+ +
Sbjct: 20296 TAENSSG----SKSATIKL-KVLDKPGPP-ASVKINKMYSDRAMLSWEPPLEDGGSEITN 20349
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
Y + R+ ++ W +V V ++ L E H Y RI A N+ G+ +P+
Sbjct: 20350 YIVDKRETSRPNWAQV-SATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPV 20401
Score = 150 bits (363), Expect = 6e-35
Identities = 177/746 (23%), Positives = 296/746 (39%), Gaps = 54/746 (7%)
Query: 1349 KVENTDAGI-YKLRL--ENNCGHADVEMN---VTILDKPSPPGKPNILEIDSSSINICWD 1402
K +N + GI Y+ R+ EN G N D PPG P + + + I + W
Sbjct: 24410 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWT 24469
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
+P G S I Y+VE +++ W+ S N+ +TQ ++ L + Y FR A N
Sbjct: 24470 KPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG 24529
Query: 1461 -ISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
IS S++T E ++ +++ ++ I E L G P P + W R
Sbjct: 24530 AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRG 24589
Query: 1519 GKKLK-TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT 1574
K+++ +A+ +N + Y A N G V + +P
Sbjct: 24590 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 24649
Query: 1575 ISNEDIK--QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIR 1631
+ K W G ++ Y + + + + E T+ ++
Sbjct: 24650 EGPVQVTGVTSEKCSLTWSPPLQDGG---SDISHYVVEKRETSRLAWTVVASEVVTNSLK 24706
Query: 1632 IKELKRSHSSKYTIEASNTAGTSS-VEVTLKVYDKPSKPEGP---VIMREISRESVTIEW 1687
+ +L + + I A N G +E + P GP + + I+++S+T+ W
Sbjct: 24707 VTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCW 24766
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P DGG E+ Y +EK + RWIK + L E+ EY FRV A+N
Sbjct: 24767 NRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAA 24826
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDN--ESVYITWFPSEKNGGSPIIDYKVE 1805
G E S V A D +D S+ + W +GGS I+ Y VE
Sbjct: 24827 GVGEP--SPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVE 24884
Query: 1806 I-KQEGKKWKXXXXXXXXXA---RIQKLSINTTYQFRIYARNEIG----TSLPYT--SDD 1855
I K + ++W+ I KL+ + Y+ R+ A N++G TS+P T +D
Sbjct: 24885 ICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPED 24944
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
K+ + + VV S + + + G P I + +G+ K+
Sbjct: 24945 KLEAPELDLDSELRKGIVVRAGGSARIHIPFK------GRPTPE--ITWSREEGEFTDKV 24996
Query: 1916 -VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLE 1974
+ G + + I+N D + + EN+ G ++S V + K P PP L
Sbjct: 24997 QIEKGVNYTQLSIDNCDRNDAGKYILKLENSSG----SKSAFVTV-KVLDTPGPPQN-LA 25050
Query: 1975 IRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSEN 2034
++ V + W P DGGA + Y I R+ T+ + V T F + +L+E
Sbjct: 25051 VKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKT-SFKVENLTEG 25109
Query: 2035 HTYMIRIYARNEIGLSEPLESDEPFK 2060
Y R+ A NE G+ P+E+ + K
Sbjct: 25110 AIYYFRVMAENEFGVGVPVETVDAVK 25135
Score = 149 bits (362), Expect = 8e-35
Identities = 178/802 (22%), Positives = 301/802 (37%), Gaps = 60/802 (7%)
Query: 1358 YKLRLENNCGHADVE--MNVTILDKP-SPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
+++ EN+ G + T+ P PPG P+ +++ +I + W+ P G S I+
Sbjct: 28756 FRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVG 28815
Query: 1415 YVVEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD-ISDASETTEYY 1471
Y +E ++ W+ + ++++ Q ++ L Y FR A N V IS S+++
Sbjct: 28816 YSIEKRQ-GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGI- 28873
Query: 1472 KVIKETKIQSPTVE---KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG----KKLKT 1524
++ + P VE + + + E + + + G P P+VTW++DG K++
Sbjct: 28874 -IMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNM 28932
Query: 1525 AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH 1584
Y A N G + V +Q P + I+ +
Sbjct: 28933 EITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVG--PIRFTN 28990
Query: 1585 KVGDE---WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
G++ W + +G P I + K E + ++K +K + +
Sbjct: 28991 ITGEKMTLWWDAPLNDGCAP---ITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGN 29047
Query: 1642 KY--TIEASNTAGT----SSVEVTLKV-YDKPSKPEGPVIMREISRESVTIEWKPPLDDG 1694
+Y + A N G S V ++ Y P P P I+ S+T+ W P DG
Sbjct: 29048 EYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE-PSNITGNSITLTWARPESDG 29106
Query: 1695 GLELTKYAIEKHEPDNNRWIKVADVDRDVET-YCIQKLNENCEYMFRVIAQNPVGFSEAL 1753
G E+ +Y +E+ E + RW+KV ET + + L E EY F V+A+N G A
Sbjct: 29107 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPAS 29166
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI-KQEGKK 1812
++ P +V + W +GG II Y +E+ K +
Sbjct: 29167 GISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGD 29226
Query: 1813 WKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQ-- 1868
W R + L Y+FR+ A N G I LT P
Sbjct: 29227 WHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDI 29286
Query: 1869 PRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE 1928
NF + +++ + G P T + K S + S +E
Sbjct: 29287 DANFKQTHVVRAGASIRLF--IAYQGRP-TPTAVWSKPDSNLSLRADIHTTDSFSTLTVE 29343
Query: 1929 NIKEKDEIIFRISAENTVGVSLPTESQSVRLE-KHATVPSPPTAPLEIRMVGSNIVMTSW 1987
N D + ++ EN G S+S+ K P PP P+ + V W
Sbjct: 29344 NCNRNDAGKYTLTVENNSG------SKSITFTVKVLDTPGPP-GPITFKDVTRGSATLMW 29396
Query: 1988 GTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P DGGA + Y + R+ ++ W + + + F + DL+E Y R+ A NE
Sbjct: 29397 DAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQI-FKVNDLAEGVPYYFRVSAVNEY 29455
Query: 2048 GLSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLR-EHNMDADIRSY 2106
G+ EP E EP A E+P + WL+ +H+ + I Y
Sbjct: 29456 GVGEPYEMPEPIV--------ATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGY 29507
Query: 2107 ARGSLLRRDEYFFRIWHYAKQL 2128
+ +++ H KQL
Sbjct: 29508 LLEMRQKGSDFWVEAGH-TKQL 29528
Score = 147 bits (355), Expect = 6e-34
Identities = 117/440 (26%), Positives = 189/440 (42%), Gaps = 28/440 (6%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD------KPSKPEGPVIMREISRESVT 1684
++ L H ++ I A N AG S+ T Y KP P P ++ + SR S++
Sbjct: 22642 KVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVL-DTSRSSIS 22700
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
I W P+ DGG E+T Y +E P+ + W I +Y I L EN EY R+ A
Sbjct: 22701 IAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 22760
Query: 1744 QNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVY-ITWFPSEKNGGSPIID 1801
N G E AL + + P + + + F K +P +
Sbjct: 22761 MNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVK 22820
Query: 1802 YKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK 1861
+ + + K + ++ + ++ + N G+ + + +
Sbjct: 22821 WARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNV------R 22874
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
L P P++ V E T SVTL W P +GGS I NYI+E + K+++ TV +
Sbjct: 22875 VLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYS---TVATN 22931
Query: 1922 VHEHC--IENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMV 1978
H+ ++ ++E FR+ AEN G+ LP E ++SV+ + P PP + + V
Sbjct: 22932 CHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASER---PLPP-GKITLMDV 22987
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
N V SW PE DGG+ +LGY + ++ W V V + I L + Y
Sbjct: 22988 TRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVT--EATITGLIQGEEYS 23045
Query: 2039 IRIYARNEIGLSEPLESDEP 2058
R+ A+NE G+S+P + P
Sbjct: 23046 FRVSAQNEKGISDPRQLSVP 23065
Score = 142 bits (344), Expect = 1e-32
Identities = 203/913 (22%), Positives = 365/913 (39%), Gaps = 83/913 (9%)
Query: 793 KPKKVKDEGVYTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINR-FQEITVKEKGT 849
K + V + V+ L +N E +AV+ E + L I + + I V E T
Sbjct: 2839 KHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKT 2898
Query: 850 IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS 909
V+ VPS+ W +N I SE G+ +L+I N +E DS +Y V
Sbjct: 2899 ASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE-DSAEYTFVCG 2956
Query: 910 NSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEIS 968
N T+ V + L K EE T+ E ++ +S KW N EI
Sbjct: 2957 NDQ------VSATLTVTPIMITSML-KDINAEEKDTITFEVTVNYEGISYKWLKNGVEIK 3009
Query: 969 GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEV 1028
D ++ + D + ++ L V+ EF + ++D +V
Sbjct: 3010 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDIKV 3069
Query: 1029 KEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
EK A+ E E++ V W +D + ++ ++ +K ++ +L I +T + D G+Y+
Sbjct: 3070 LEKKRAMFECEVSEPDITVQWMKDDQELQIT-DRIKIQKEKYVHRLLIPSTRMSDAGKYT 3128
Query: 1089 CILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQF 1148
+ TA++ V I + + +V + +A E E+ + D W+KDG EI F
Sbjct: 3129 VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINF 3188
Query: 1149 S--NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFI 1206
+ ++ + ++ I + DAGEY+ G ++ + L V P L+ + +
Sbjct: 3189 QVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPV 3248
Query: 1207 LVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V + A I ++WYK++ ++ K + D ++ TL++ + +D
Sbjct: 3249 TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAV 3308
Query: 1266 YTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD-YQAFPQP-ND 1319
YTC + A ++ L VEV P++V ++E + + +T L D + QP
Sbjct: 3309 YTCEAKNDYGVATTSASLSVEV----PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3364
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
+ V+ +K ++K S + + E+T Y+L + + + E T +
Sbjct: 3365 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT----YQLEIAE--AYPEDEGTYTFVA 3418
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
N + SS+ N+ + PE+ I++ +E QEI+ + +K + + S
Sbjct: 3419 S-------NAVGQVSSTANLSLEAPES-----ILHERIE-QEIE----MEMKEFSSSFLS 3461
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNED 1498
+ +S+ + +NE + SE+ Y K E + P K + N +
Sbjct: 3462 AEEEGLHSA-ELQLSKINET-LELLSESPVYSTKFDSEKEGTGPIFIKEVSNADISMGDV 3519
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-----NRXXXXXXXXXXXXXXXYKCIAF 1553
L+ G+P+PK+ W+ +G L T A Y+ + Y C+A
Sbjct: 3520 ATLSVTVIGIPKPKIQWFFNG-VLLTPSADYKFVFDGDDHSLIILFTKLEDEGEYTCMAS 3578
Query: 1554 NDHGEVETSCVVGIQQK----------PVITISNED---------IKQKHKVGDEWLVTA 1594
ND+G+ S + I K + S E +K+ + + A
Sbjct: 3579 NDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPA 3638
Query: 1595 VIE----GIPPPEVIWYKNGNKLENDKEYNITTKEKTS-VIRIKELKRSHSSKYTIEASN 1649
+ E G P P V W+K +L Y I S + + +R S Y +A N
Sbjct: 3639 IFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAEN 3698
Query: 1650 TAGTSSVEVTLKV 1662
G S+ L V
Sbjct: 3699 MLGESTCAAELLV 3711
Score = 140 bits (338), Expect = 7e-32
Identities = 102/345 (29%), Positives = 149/345 (43%), Gaps = 14/345 (4%)
Query: 1739 FRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSP 1798
+ + A N G ++A + IV+ LD P I ESV + W P + +GGS
Sbjct: 27474 YEITAANSSGTTKAFIN--IVV---LDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQ 27528
Query: 1799 IIDYKVEIKQEGKK--W-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDD 1855
+ +Y + +K+E W + ++ KL+ YQFRI A N G S +
Sbjct: 27529 VTNY-ILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGIS-DHIDSA 27586
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+T+ T P P V+ T S+T+ W EP SNGGS + Y +E K W K
Sbjct: 27587 CVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQKA 27646
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ + I FR+ AEN GV P+ L A P + I
Sbjct: 27647 NKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDAC---EPPRNVRI 27703
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENH 2035
+ N V SW P +DGG+ + GY + RD+ W + +V +F I L++N
Sbjct: 27704 TDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNS 27763
Query: 2036 TYMIRIYARNEIG-LSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
Y R++ARN +G +S P E P I G + P E TEV
Sbjct: 27764 QYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEV 27808
Score = 140 bits (338), Expect = 7e-32
Identities = 178/778 (22%), Positives = 318/778 (40%), Gaps = 62/778 (7%)
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY-SCEV-GNSKC 1185
IE+ K D L W K +E +T ++ K ++ AG+ SCEV G K
Sbjct: 29217 IEMCKAD-LGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKA 29275
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLI 1245
LT E I+ + + A+ ++ + T W K S + + + +
Sbjct: 29276 VDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQ-GRPTPTAVWSKPDSNL--SLRADIH 29332
Query: 1246 SDVKKRTLIIRKCTEDDQCEYTCVLLD---AKSTT-KLKVEVVEFPPKIVDYEREYRIKR 1301
+ TL + C +D +YT + + +KS T +KV PP + ++ + R
Sbjct: 29333 TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKD---VTR 29389
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS--IDSKSASLTIKKVENTDAGI-- 1357
GS TL+ D P + ++ +++K + ++ S + S+ + I KV + G+
Sbjct: 29390 GS-ATLMWDA---PLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPY 29445
Query: 1358 -YKLRLENNCGHAD-VEMNVTIL--DKPSPPGKPNILEIDSSSINICWDEPENTGNSTII 1413
+++ N G + EM I+ ++P+PP + ++++ SS + W +P++ G S I
Sbjct: 29446 YFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRIT 29505
Query: 1414 YYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
Y++E ++ + W+ + + +++ L + Y FR A N+ S+ E +
Sbjct: 29506 GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSV-I 29564
Query: 1474 IKETKIQSPTVEKPLKN--ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK----TAKA 1527
IKE +I+ + N IT + + G P PKVTW + +LK +
Sbjct: 29565 IKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSIT 29624
Query: 1528 TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVG 1587
T ++R Y N G S V + +P ++ V
Sbjct: 29625 TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVS---SVS 29681
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKY--- 1643
E + V+ P + + N + +E T + S ++ ++K +H +KY
Sbjct: 29682 AE---SCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEY 29738
Query: 1644 --TIEASNTAGTSSVEVTLKV-----YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGL 1696
+ + N G S + + + PS P P + +S +++I W+ P DGG
Sbjct: 29739 SFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVY-HVSANAMSIRWEEPYHDGGS 29797
Query: 1697 ELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-S 1755
++ Y +EK E + W+K V Y + L E EY FR A N G S+A E S
Sbjct: 29798 KIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEAS 29857
Query: 1756 EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK---- 1811
PI+ + +D P + +V + W +GGS ++ Y +E K +
Sbjct: 29858 RPIMAQNPVDAPG----RPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDG 29913
Query: 1812 KWK--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKTLTPP 1866
+W + LS TY+FR+ A+N G S S +T PP
Sbjct: 29914 RWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPP 29971
Score = 134 bits (323), Expect = 4e-30
Identities = 205/920 (22%), Positives = 361/920 (39%), Gaps = 86/920 (9%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
KKPK E + + E + P + W K EI P + + E +H L +
Sbjct: 2799 KKPKDVTALENATVAFEVSVSHDTVP-VKWFHKNVEIKPSDKHRLVSERKVHK----LML 2853
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
N+ G YT V E +A L + E + + +K++ V + ++ +
Sbjct: 2854 QNISPSDAGEYTAVVGQLECKAKLFV---------ETLHITKTMKNIEVPETKTASFECE 2904
Query: 758 VVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V P++ W KN ++ G H + I+ +D YT N +
Sbjct: 2905 VSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTS-TEDSAEYTFVCGNDQ--- 2959
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
SA +TV P + + ++I +EK TI V + S W +N I
Sbjct: 2960 -VSATLTVT--------PIMITSMLKDINAEEKDTITFEVTVNYEGI-SYKWLKNGVEIK 3009
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL 934
++ L I NV D+ DY VA GK++ A + ++ + F KH+
Sbjct: 3010 STDKCQMRTKKLTHSLNIRNVHFG-DAADYTFVA----GKATSTATLYVEARHIEFRKHI 3064
Query: 935 QKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD 993
K + E K + EC+ S ++ +W + +E+ D +I +E D
Sbjct: 3065 -KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3123
Query: 994 VGVIKCIVKDQETSTMLVVKETIPEFIRKLQ-DFEVKEKDVAILEVEINSETADVVWERD 1052
G +V ST + E IR ++ + +V EK A++E E+N + D W +D
Sbjct: 3124 AGKYT-VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3182
Query: 1053 GEIIK---PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL-RDESCTAEVTVVELPPE 1108
G I +++KY E+R H +++I T D GEY+ + R+ S PP+
Sbjct: 3183 GIEINFQVQERHKYVVERRIH--RMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQ 3240
Query: 1109 IITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
++ LQ V G A F ++ + + W+K+ + + DG++ L + +
Sbjct: 3241 VLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIE 3300
Query: 1168 CDLDDAGEYSCEVGN----SKCTAILTVEEPSI-NFTLRLPEF---ILVPANTD------ 1213
+DA Y+CE N + +A L+VE P + + +P + I+ P
Sbjct: 3301 AFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQ 3360
Query: 1214 -AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
A + L V+WY K I+ + F + L I + +D+ YT V +
Sbjct: 3361 PARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASN 3420
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI-IKKC 1331
A + P+ + +E RI++ ++ + +F +E + ++++ + K
Sbjct: 3421 AVGQVSSTANLSLEAPESILHE---RIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKI 3477
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAG-IYKLRLEN-NCGHADV-EMNVTILDKPSPPGK-- 1386
T + T E G I+ + N + DV ++VT++ P P +
Sbjct: 3478 NETLELLSESPVYSTKFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWF 3537
Query: 1387 -PNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKT 1445
+L S+ +D + +S II + E + T ++ + KT S LK
Sbjct: 3538 FNGVLLTPSADYKFVFDGDD---HSLIILFTKLEDEGEYT-CMASNDYGKTICSAY-LKI 3592
Query: 1446 NSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF 1505
NS E ++ + E K P K LK I
Sbjct: 3593 NSKGEGHKDTETESAVAKSLE--------KLGGPCPPHFLKELKPIRCAQGLPAIFEYTV 3644
Query: 1506 GGVPQPKVTWYRDGKKLKTA 1525
G P P VTW+++ K+L T+
Sbjct: 3645 VGEPAPTVTWFKENKQLCTS 3664
Score = 133 bits (321), Expect = 8e-30
Identities = 118/411 (28%), Positives = 171/411 (41%), Gaps = 31/411 (7%)
Query: 1666 PSKPEGPVIMREIS---RESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
P KP GP E+S ++S+ + W P+DDGG E+ Y +EK + + RW K
Sbjct: 25825 PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLT 25884
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV--PSXXXXXXXXXXID 1780
+ L E Y FRV A+N G E SEP V A D P
Sbjct: 25885 DLRLRVTGLTEGHSYEFRVAAENAAGVGEP--SEPSVFYRACDALYPPGPPSNPKVTDTS 25942
Query: 1781 NESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXAR---IQKLSINTTYQ 1836
SV + W +GG+P+ Y VE+K+ +W + + KL NT Y
Sbjct: 25943 RSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYN 26002
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPP-----SQPRNFVVSESTSRSVTLKWTEPES 1891
FRI A N G P T + + + PP + R VV + S TL+
Sbjct: 26003 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA---SATLRLFVTIK 26059
Query: 1892 NGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
P ++++ +G + + V S I+N+ D + ++ EN G
Sbjct: 26060 GRPEP----EVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSK- 26114
Query: 1951 PTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTK 2010
T +VR+ PS P L IR V + V SW P DGGA + Y + R+ T+
Sbjct: 26115 -TAFVNVRV---LDSPSAP-VNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTR 26169
Query: 2011 TMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
+ + T F I +L E +Y R+ A NE G+ P E+ EP KV
Sbjct: 26170 KAYATITNNCTKT-TFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKV 26219
Score = 130 bits (313), Expect = 7e-29
Identities = 142/602 (23%), Positives = 246/602 (40%), Gaps = 42/602 (6%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
+E P+F + L P +G VQ C V+G +I W + IKPS D +
Sbjct: 9267 KEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPS-DRCSFSFAS 9325
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
A L +R+V D+G + C A N AG S TT+ S++T+
Sbjct: 9326 GTAVLELRDVAKADSGDYVCKASNVAG--SDTTK-----------SKVTIKDKPAVAPAT 9372
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
A + +G F +P++ V E + ++ P P++ W KG+ ++ V
Sbjct: 9373 KKAAV-DG-RLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWT-KGKWRQLNQGGRVF 9429
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS 743
I + L+I + K G Y VA N GE + L++ +K+ ++ L++
Sbjct: 9430 IHQKGDE--AKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQ-EKIEGDLRA 9486
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKP----KKVK 798
M+ + ++ + KN P + + G T +L+ K+ +
Sbjct: 9487 MLKK--TPILKKGAGEEEEIDIMELLKNVDPKEYEKYARMYGITDFRGLLQAFELLKQSQ 9544
Query: 799 DEGVYTLKAENSE----GIAETSAVITVEEPTEENAEPPLFINRFQEITV-KEKGTIKLV 853
+E + L+ E E E +++ + EP I + TV K+ + +
Sbjct: 9545 EEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTEPVTLIKDIENQTVLKDNDAVFEI 9604
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P ++WY+ E + PS+ + DG+ L + N + D G+Y+ V
Sbjct: 9605 DIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLK-DQGNYRLVC----- 9658
Query: 914 KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDH 972
H A + V + + +HLQ +EG+T + CQ S V ++W+ N + +
Sbjct: 9659 -GPHIASAKLTVIEPAWERHLQ-DVTLKEGQTCTMTCQFSVPNVKSEWFRNGRILKPQGR 9716
Query: 973 REIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKD 1032
+ E + D G C +D ETS L ++ +F +++Q+ V E
Sbjct: 9717 HKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKRIQNIVVSEHQ 9776
Query: 1033 VAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
A E E++ + A V W + G + KY+F G + I N + DEG YS I R
Sbjct: 9777 SATFECEVSFDDAIVTWYK-GPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIAR 9835
Query: 1093 DE 1094
E
Sbjct: 9836 LE 9837
Score = 129 bits (311), Expect = 1e-28
Identities = 112/445 (25%), Positives = 188/445 (42%), Gaps = 29/445 (6%)
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLK--VYDKPSKPEGPVI---MREISRESVT 1684
++++ L H ++ ++A N G + + V P +P GP + + ++ S+T
Sbjct: 19382 MKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSIT 19441
Query: 1685 IEWKPPLDDGGLELTKYAIEKH------EPDNNRWIKVADVDRDV-ETYCIQKLNENCEY 1737
+ W P+ DGG + Y +E PD W + + V + + + L+EN EY
Sbjct: 19442 LGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-WKRCNAAAQLVRKEFTVTSLDENQEY 19500
Query: 1738 MFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXX-IDNESVYITWFPSEKNG 1795
FRV AQN VG E E I K L+ P I I F +
Sbjct: 19501 EFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGR 19560
Query: 1796 GSPIIDY-KVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSD 1854
+P + + KV I +K + I + + + ++ + N G + +
Sbjct: 19561 PAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNV 19620
Query: 1855 DKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTK 1914
+ L P + VS+ T S + W PE++GGS +T+YI+E + K+W+
Sbjct: 19621 ------RVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWST 19674
Query: 1915 IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPL 1973
+ H + N+ +E FR++A N G +PT+ + V + P PP L
Sbjct: 19675 VTPEVKKTSFH-VTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPP-RKL 19732
Query: 1974 EIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTK--TMWMEVGKVDVNTLKFNIRDL 2031
E+ + N +W P DGGA + GY + R+ + W E V L + L
Sbjct: 19733 EVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSV--VKDLSLVVTGL 19790
Query: 2032 SENHTYMIRIYARNEIGLSEPLESD 2056
E Y R+ ARN +G+S P E++
Sbjct: 19791 KEGKKYKFRVAARNAVGVSLPREAE 19815
Score = 125 bits (302), Expect = 2e-27
Identities = 86/303 (28%), Positives = 131/303 (43%), Gaps = 7/303 (2%)
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-K 1812
+S PI +K LD P + E Y+ W P ++GG+ I Y +E ++ +
Sbjct: 25717 KSIPITVKV-LDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLS 25775
Query: 1813 W-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
W + ++ KL Y FR+ A N+ G P S +T PP P
Sbjct: 25776 WTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGP-VTACNPYKPPGPPST 25834
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIK 1931
VS T S+ + W P +GG+ I YI+E + +G WTK + + +
Sbjct: 25835 PEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLT 25894
Query: 1932 EKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP 1990
E FR++AEN GV P+E S R P PP+ P ++ + V +W P
Sbjct: 25895 EGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNP-KVTDTSRSSVSLAWSKP 25953
Query: 1991 EWDGGAPLLGYNIAIRDVTKTMWME-VGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGL 2049
+DGGAP+ GY + +++ W + +F + L EN Y RI A N G+
Sbjct: 25954 IYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGV 26013
Query: 2050 SEP 2052
EP
Sbjct: 26014 GEP 26016
Score = 124 bits (300), Expect = 3e-27
Identities = 90/303 (29%), Positives = 135/303 (44%), Gaps = 11/303 (3%)
Query: 1757 PIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKX 1815
PI + T L PS I +SV ++W E NGG I Y +E ++ + WK
Sbjct: 28575 PITVIT-LGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKM 28633
Query: 1816 XXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK-TLTPPSQPRNFV 1873
++ L + YQFR+ A N G S P S I + K P P V
Sbjct: 28634 VCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSS--IIVAKHQFRIPGPPGKPV 28691
Query: 1874 VSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEK 1933
+ TS ++L W P +GGS +T + +E K W K+ T S E+ + E
Sbjct: 28692 IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEG 28751
Query: 1934 DEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+ FR+ AEN+ G+S P++ L + PP P I + I + W P D
Sbjct: 28752 LDYQFRVYAENSAGLSSPSDPSKFTLA--VSPVDPPGTPDYIDVTRETITL-KWNPPLRD 28808
Query: 1994 GGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG-LSEP 2052
GG+ ++GY+I R + W+ DV+ ++ + LS Y RI ARN +G +S P
Sbjct: 28809 GGSKIVGYSIEKRQGNER-WVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPP 28867
Query: 2053 LES 2055
+S
Sbjct: 28868 SQS 28870
Score = 124 bits (298), Expect = 5e-27
Identities = 123/454 (27%), Positives = 188/454 (41%), Gaps = 34/454 (7%)
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
T+ ++ L ++ ++A N G S + L V + + P I +S TI+
Sbjct: 16278 TTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVP-PTIKLRLSVRGDTIK 16336
Query: 1687 WKP------PLDDGGLELTKYAIEKHE-----PDNNRWIKVADVDR-DVET-YCIQKLNE 1733
K P D GL + K K+E P + I +V R + +T I K
Sbjct: 16337 VKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVR 16396
Query: 1734 NCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEK 1793
+ + V A N +G + + + D PS I ES Y+TW
Sbjct: 16397 EDKGTYTVTASNRLG--SVFRNVHVEV---YDRPSPPRNLAVTD-IKAESCYLTWDAPLD 16450
Query: 1794 NGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXAR-IQKLSINTTYQFRIYARNEIGTSL 1849
NGGS I Y ++ + +K W+ I KL N Y+FR+ A N+ G S
Sbjct: 16451 NGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISD 16510
Query: 1850 PYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKG 1909
SD K+ I P P V T S+ + WT P NGGSPIT Y +E +
Sbjct: 16511 ECKSD-KVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGS 16569
Query: 1910 KSWTK-----IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHAT 1964
W++ I VG E + + E + FR A N G+ P+E +
Sbjct: 16570 PYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPI 16629
Query: 1965 VP-SPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD--V 2021
P PP+ P E++ + + W P DGG+P+ GY + +++ T W V + D +
Sbjct: 16630 FPPGPPSCP-EVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLI 16688
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
T + + +L E Y R+ A NE G SEP ++
Sbjct: 16689 TTCECVVPNLKELRKYRFRVKAVNEAGESEPSDT 16722
Score = 123 bits (297), Expect = 6e-27
Identities = 83/293 (28%), Positives = 131/293 (44%), Gaps = 15/293 (5%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK--WKXXXXXXXX-XARIQKLSINTTY 1835
+ ++ + W P E +GG I +Y +E K E K+ W + +L Y
Sbjct: 19235 VSSDRCTVCWDPPEDDGGCEIQNYILE-KCETKRMVWSTYSATVLTPGTTVTRLIEGNEY 19293
Query: 1836 QFRIYARNEIGTSLPYTSDDKITIGKT-LTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
FR+ A N+IGT P ++ K I KT P +P V++ + +T+ W PE +GG
Sbjct: 19294 IFRVRAENKIGTGPP--TESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGG 19351
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT-E 1953
IT Y +E K W + ++N+ E FR+ AEN +G+ P+
Sbjct: 19352 KSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLP 19411
Query: 1954 SQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMW 2013
S+ V + P PPT + +I + WG P +DGGAP++GY + +R
Sbjct: 19412 SRPVVAKDPIEPPGPPTNFRVVDTTKHSITL-GWGKPVYDGGAPIIGYVVEMRPKIADAS 19470
Query: 2014 MEVGKVDVNTL------KFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
+ G N +F + L EN Y R+ A+N++G+ P E E K
Sbjct: 19471 PDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIK 19523
Score = 122 bits (295), Expect = 1e-26
Identities = 154/698 (22%), Positives = 277/698 (39%), Gaps = 38/698 (5%)
Query: 1012 VKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHI 1071
+KE P L D +E D+ L I + +V W + +++ P K+ + +
Sbjct: 4284 IKEDGPMIHTPLVDTVSEEGDIVHLTTSITN-AKEVNWYFENKLV-PSDEKFKCLQDQNT 4341
Query: 1072 RKLYIRNTSVHD-EGEYSC-ILRDESCTA---EVTVVELPPEIITR-LQNQKVNKGNKAT 1125
L I + D +GEY C L D TA ++TVV+ +I R ++ +V G+ A
Sbjct: 4342 YTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAK 4401
Query: 1126 FEIELTKG-DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EV 1180
F E+ + +WFK G EI S+ + L+I + D GEY+C E
Sbjct: 4402 FTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEY 4461
Query: 1181 GNSKCTAILTVEEPSINFTLRLPEFILVPANTDA-YLTVEIPDETLDVTWYKKKSVIEDT 1239
G+ CTA LTV E L P+ + A ++ ++ W K + + +
Sbjct: 4462 GSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPS 4521
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE--VVEFPPKIVDYER-E 1296
+ + K L + T D+ Y+C + + E +++ P I + E +
Sbjct: 4522 PNWKISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQ 4581
Query: 1297 YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAG 1356
I + + VD + W + + + K K + K A+L I + D+G
Sbjct: 4582 SAINKKVHLECQVDEDR--KVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSG 4639
Query: 1357 IYKLRLENNCGHADVEMNVTILDKPSPPGK--PNILEIDSSSINI-CWDEPENTGNSTII 1413
Y N G + VT+ + PS K P+ L + S + C + T
Sbjct: 4640 TYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWF 4699
Query: 1414 YYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
E E +T V + + I ++K S + AVN D+ S +TE V
Sbjct: 4700 KNNKELSESNTVRMYFVNS--EAILDITDVKVEDSGSYSCEAVN--DVGSDSCSTEI--V 4753
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TY 1529
IKE P+ K L+ + L C G +++W++D K+++++K +
Sbjct: 4754 IKEP----PSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQ 4809
Query: 1530 ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDE 1589
++ Y+C+ N+ G+ +++ P +D+ G
Sbjct: 4810 KSLVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALG--GQT 4867
Query: 1590 WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
+ A + G P V W K + D + ++ +V+ I +++ S KYT A N
Sbjct: 4868 VTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAEN 4927
Query: 1650 TAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEW 1687
AG+ + L V + E +++ + + T+E+
Sbjct: 4928 EAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEY 4965
Score = 120 bits (288), Expect = 8e-26
Identities = 88/313 (28%), Positives = 139/313 (44%), Gaps = 10/313 (3%)
Query: 1764 LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXX 1822
LD P + E + W P ++GGS II+Y VE ++ + W
Sbjct: 23561 LDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQT 23620
Query: 1823 XA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS 1881
+ ++ KL Y FRI A N+ G P S+ + + P + P+ V+ T S
Sbjct: 23621 LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDA-PKAPEVTTVTKDS 23679
Query: 1882 VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRI 1940
+ + W P S+GGS I Y++E + +G WT+ + G + + + E + FR+
Sbjct: 23680 MIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLR-VTGLIENHDYEFRV 23738
Query: 1941 SAENTVGVSLPTESQSVRLEKHATV-PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLL 1999
SAEN G+S P+ + + P PP P I + S++ + SW P +DGG +
Sbjct: 23739 SAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFL-SWSKPIYDGGCEIQ 23797
Query: 2000 GYNIAIRDVTKTMW-MEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
GY + DV+ W M +N + L E H Y RI A N+ G+ E +D P
Sbjct: 23798 GYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGE--HADVP 23855
Query: 2059 FKVIPGEGSHADE 2071
+I E A +
Sbjct: 23856 GPIIVEEKLEAPD 23868
Score = 115 bits (276), Expect = 2e-24
Identities = 109/456 (23%), Positives = 179/456 (39%), Gaps = 28/456 (6%)
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
EY++ V +KE K+ K+ + A N G S VY+ + P I+
Sbjct: 19776 EYSVVKDLSLVVTGLKEGKKY---KFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMP 19832
Query: 1678 ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEY 1737
E +TI+ L + + K P +W K D + K + +
Sbjct: 19833 ---EQITIKAGKKL-----RIEAHVYGKPHP-TCKWKKGEDEVVTSSHLAVHKADSSSIL 19883
Query: 1738 MFRVIAQNPVGF-------SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
+ + + + G+ S +++ I + +D P ID ++ ++W
Sbjct: 19884 IIKDVTRKDSGYYSLTAENSSGTDTQKIKV-VVMDAPGPPQPPFDISDIDADACSLSWHI 19942
Query: 1791 SEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTS 1848
++GGS I +Y VE + W + R+ KL Y FR+ A N G S
Sbjct: 19943 PLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGIS 20002
Query: 1849 LPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVK 1908
P TS K+ PS+P+N V++ + + W P+S+GGSPI Y+IE K
Sbjct: 20003 EPLTSP-KMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN 20061
Query: 1909 GKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
W K E+ + E E FRI A N G S P++ A +P
Sbjct: 20062 SLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVT---ARMPVD 20118
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV--DVNTLKF 2026
P E+ V + V W P+ DGG+ ++GY + + W+ + ++
Sbjct: 20119 PPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEY 20178
Query: 2027 NIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVI 2062
L E Y R AR + +S P E +P ++
Sbjct: 20179 TATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 20214
Score = 107 bits (258), Expect = 3e-22
Identities = 105/448 (23%), Positives = 177/448 (39%), Gaps = 41/448 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P V L+ +G +V EC + GYP P +TW+R+ I+ S DFQ+ + +A L+
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF-QSGIARLM 1001
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXXXXXXXXAD 627
IRE F ED+G FTC A N AG S++ L V+ + +T D
Sbjct: 1002 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRD 1061
Query: 628 IL--------------EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEE 673
++ E P F KP Q + EG ++ C++ P+P + W G
Sbjct: 1062 VVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVP 1121
Query: 674 IVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE 733
+ V+ V+ +T G YT+V N+ GE S L E +
Sbjct: 1122 LTTGYRYKVSYNKQTGECKLVISMTFAD--DAGEYTIVVRNKHGETSASASL---LEEAD 1176
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
+++ + M+ + + + VG P + + K + T++
Sbjct: 1177 YELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVV 1236
Query: 794 PKKVKDEGVYTLKAENS--EGIAETSAVITVEEPTEENAEPPLFIN-------------R 838
V+D+ + E + I T+EE EE+ E + ++ R
Sbjct: 1237 RTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDLR 1296
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF--DGENIELVITNVD 896
+ + E + +++ P+P I WY++ + I E +F DG L I V
Sbjct: 1297 IKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVL 1355
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTID 924
E D G Y ASN G + ++ ++
Sbjct: 1356 PE-DEGIYTAFASNIKGNAICSGKLYVE 1382
Score = 107 bits (258), Expect = 3e-22
Identities = 77/283 (27%), Positives = 123/283 (43%), Gaps = 11/283 (3%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK---KWKXXXXXXXXXA-RIQKLSINTT 1834
I SV W P +GGS II+Y +E K + K +W + KL
Sbjct: 15740 IRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKE 15799
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
Y FR+ A N G P S + PP P +V + TS S+ +KW EP+ NG
Sbjct: 15800 YLFRVRAENRFGPGPPCVSKPLVA-KDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNG- 15857
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
SPI Y +E + V W+++ + + ++ + E +FR+ AEN G P +
Sbjct: 15858 SPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAG---PGKF 15914
Query: 1955 QSVRLEKHATVP-SPPTAPL-EIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM 2012
K A P SPP P+ + S + W P ++GG ++GY + + V
Sbjct: 15915 SPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNE 15974
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
W + + ++ ++++ E Y +R+ A N G P E+
Sbjct: 15975 WSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGET 16017
Score = 107 bits (258), Expect = 3e-22
Identities = 80/287 (27%), Positives = 127/287 (44%), Gaps = 12/287 (4%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXA-RIQKLSINTTYQ 1836
+ ES ++W + GG+ I +Y VE ++ G W+ ++ L+ Y
Sbjct: 29680 VSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYS 29739
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
FR+ + N G S P S I PPS P V ++ +++++W EP +GGS
Sbjct: 29740 FRVSSENRFGVSKPLESAP-IIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSK 29798
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQ 1955
I Y +E K W K V + + + E E FR A N GVS +E S+
Sbjct: 29799 IIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASR 29858
Query: 1956 SVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKT---M 2012
+ + P P E+ V + V W P +DGG+ ++GY I + V++
Sbjct: 29859 PIMAQNPVDAPGRP----EVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGR 29914
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG-LSEPLESDEP 2058
W++ V+ F + LSE TY R+ A+N G +S+ ES P
Sbjct: 29915 WLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGP 29961
Score = 107 bits (256), Expect = 6e-22
Identities = 116/515 (22%), Positives = 208/515 (40%), Gaps = 31/515 (6%)
Query: 1554 NDHGEVETSCVVGIQQK--PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWY--KN 1609
NDHG + C V + P I EDI+ K V +W + +G E+I Y +
Sbjct: 15712 NDHGIAKAPCTVSVLDTPGPPINFVFEDIR-KTSVLCKW-EPPLDDG--GSEIINYTLEK 15767
Query: 1610 GNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAG-----TSSVEVTLKVY 1663
+K + D E+ + T + + +L + + A N G S V +
Sbjct: 15768 KDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPF 15827
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
P P+ P++ +++ S+ ++W P D+G + Y +EK E ++ W +V +
Sbjct: 15828 GPPDAPDKPIV-EDVTSNSMLVKWNEPKDNGS-PILGYWLEKREVNSTHWSRVNKSLLNA 15885
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALD-VPSXXXXXXXXXXIDNE 1782
+ L E Y+FRV A+N G + S P KTA D + +
Sbjct: 15886 LKANVDGLLEGLTYVFRVCAENAAGPGKF--SPPSDPKTAHDPISPPGPPIPRVTDTSST 15943
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXAR--IQKLSINTTYQFRI 1839
++ + W P NGG I+ Y V+ + G +W + ++++ Y+ R+
Sbjct: 15944 TIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRV 16003
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N G P +T+ + PP+ + V P G P+
Sbjct: 16004 SAVNAAGEG-PPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPT 16062
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
+ + + ++ G+ E I++ KD + I+A N+ G ++ + R+
Sbjct: 16063 KVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCG----SKFAAARV 16118
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
E VP P L+ + + + +W PE DGG+ + G+ I +D W + +
Sbjct: 16119 EVF-DVPG-PVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQ--PI 16174
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
+ K +I L E Y R+ A+N+ G P+E
Sbjct: 16175 ETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVE 16209
Score = 99 bits (238), Expect = 9e-20
Identities = 108/439 (24%), Positives = 183/439 (41%), Gaps = 33/439 (7%)
Query: 1044 TADVVWERD-GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT--AEV 1100
T ++ W R+ GE +K EK + +L I N +D G+Y L + S + A V
Sbjct: 24980 TPEITWSREEGEFT----DKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFV 25035
Query: 1101 TVVELP-PEIITRLQNQKVNKGNK-ATFEIELTKGDALVR-WFKDGSEIQFSNHIQLTID 1157
TV L P L ++V K + +E + G A V+ + D E + ++
Sbjct: 25036 TVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSK 25095
Query: 1158 GKKQKLK--------IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
K K IY + E+ V A+ E PS + L +
Sbjct: 25096 CSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDV---- 25151
Query: 1210 ANTDAYLTVEIP--DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ T A L E P D V Y + + TEK++++++ K ++ + + ++
Sbjct: 25152 SQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFR 25211
Query: 1268 CVLLDAKSTTKLKVEVVEFPPKIVDYE-------REYRIKRGSDVTLLVDYQAFPQPNDE 1320
+ K + +V V K + + Y I+ G D+ + + P+PN
Sbjct: 25212 VKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNIS 25271
Query: 1321 WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
W+ + + +K+ + S L IK+ D G Y + N+ G A ++V +L+K
Sbjct: 25272 WVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 25331
Query: 1381 PSPP-GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQT 1438
P PP G E+ + + I W+ P TG I Y+VE ++ TT W V + +T
Sbjct: 25332 PGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTI 25391
Query: 1439 SIQNLKTNSSYRFRAYAVN 1457
I LKT + Y+FR +A N
Sbjct: 25392 KITKLKTGTEYQFRIFAEN 25410
Score = 91.5 bits (217), Expect = 3e-17
Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA--LP----TKSDGDT 786
+ P +PL+S++V +G + A + G P P ++W ++ + + LP + SDG
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
+TI K + G Y+LKA N G A ++A + V+ T PP F+ R Q +TV++
Sbjct: 64 -KLTIPAVTKA-NSGRYSLKATNGSGQATSTAELLVKAETA----PPNFVQRLQSMTVRQ 117
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
++L RVT P P + +YR+ I S + +G+ L+I E DSG Y
Sbjct: 118 GSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPE-DSGTYSV 176
Query: 907 VASNSAGKSSHGARVTIDVEK 927
A+NS G+++ A + + E+
Sbjct: 177 NATNSVGRATSTAELLVQGEE 197
Score = 91.5 bits (217), Expect = 3e-17
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTH 787
+P V++P+ S +G++ +VVG P P W + + + + K DG T
Sbjct: 1456 KPVFVLKPV-SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG-TQ 1513
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
S+ I+ P D G +T+ A+N G + S ++TVE E+ P+F+ + + + +KE
Sbjct: 1514 SLIIV-PATPSDSGEWTVVAQNRAGRSSISVILTVE--AVEHQVKPMFVEKLKNVNIKEG 1570
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEI--DSGDYK 905
+++ R T NP P I W +N++II P + +G E + +DS + DS Y
Sbjct: 1571 SQLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL-KIDSTVSQDSAWYT 1629
Query: 906 CVASNSAGKSSHGARVTIDVE 926
A N AG+ + +V ++VE
Sbjct: 1630 ATAINKAGRDTTRCKVNVEVE 1650
Score = 89.0 bits (211), Expect = 2e-16
Identities = 54/175 (30%), Positives = 80/175 (45%), Gaps = 9/175 (5%)
Query: 1298 RIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK----CKHTKPSIDSKSAS--LTIKKVE 1351
++K G V + D P P EW N +I+K + TK + A L+I K
Sbjct: 16336 KVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAV 16395
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
D G Y + N G ++V + D+PSPP + +I + S + WD P + G S
Sbjct: 16396 REDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSE 16455
Query: 1412 IIYYVVEYQEID--TTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISD 1463
I +YV++ ++ EW V N + + I L N Y FR AVN+ ISD
Sbjct: 16456 ITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISD 16510
Score = 88.2 bits (209), Expect = 3e-16
Identities = 61/202 (30%), Positives = 99/202 (49%), Gaps = 9/202 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYC 692
PTF++ ++ V EGS E + P P+++W G+ I V I SD
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR--- 62
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L I V K G Y++ A N G+A+ L +K E PP ++ L+SM VRQG V
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-ETAPPNFVQRLQSMTVRQGSQV 121
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L +V G P P + + ++ +++ +GD +S+ I + +D G Y++ A N
Sbjct: 122 RLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYP-EDSGTYSVNATN 180
Query: 810 SEGIAETSAVITVEEPTEENAE 831
S G A ++A + V+ E A+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAK 202
Score = 87.0 bits (206), Expect = 7e-16
Identities = 109/506 (21%), Positives = 193/506 (38%), Gaps = 39/506 (7%)
Query: 598 LIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
++ +A L D G+ + + + L + P K V E +++ C
Sbjct: 13536 VVKDATLQDMGTYVVMVGAARAAAHLTVIEKLRIVVPL-----KDTRVKEQQEVVFNCE- 13589
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
V W F+ EE + D + + ++ D+ +Y L+I + + Y V N G
Sbjct: 13590 VNTEGAKAKW-FRNEEAIFDSSKYIILQKDL-VY--TLRIRDAHLDDQANYNVSLTNHRG 13645
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-- 775
E I E+E +++EPLK + + +SV + V T+ W KN + V
Sbjct: 13646 ENVKSAANLIV--EEEDLRIVEPLKDIETMEKKSVTFWCK-VNRLNVTLKWTKNGEEVPF 13702
Query: 776 -KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPL 834
+ + D H +TI K DEG Y + A + +AE ++ +E PTE
Sbjct: 13703 DNRVSYRVDKYKHMLTI-KDCGFPDEGEYIVTAGQDKSVAE---LLIIEAPTE------- 13751
Query: 835 FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITN 894
F+ ++ TV E +++R ++ WYRN I + DG L+I +
Sbjct: 13752 FVEHLEDQTVTEFDDAVFSCQLSREKA-NVKWYRNGREIKEGKKYKFEKDGSIHRLIIKD 13810
Query: 895 VDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH 954
+ D +Y C + + AR+ ++ V ++ Q E V L
Sbjct: 13811 CRLD-DECEYACGVEDRKSR----ARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNKD 13865
Query: 955 TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKE 1014
V +W N + D +++ EG+ D G + I KD+E L +
Sbjct: 13866 KVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLEL-A 13924
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
P+ QD V + V ++ A+ W ++ E + K +
Sbjct: 13925 AAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTK----TIDTTAEQTS 13980
Query: 1074 LYIRNTSVHDEGEYSCILRDESCTAE 1099
I D+G Y +L+++ AE
Sbjct: 13981 FRILEAKKGDKGRYKIVLQNKHGKAE 14006
Score = 86.2 bits (204), Expect = 1e-15
Identities = 61/211 (28%), Positives = 94/211 (44%), Gaps = 9/211 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F KP + EG + ++V P P+ W G++IV D V I+ D
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE-PPQVIEPLKSMIVRQGESV 752
++ T G +TVVA NR G +S+ ++L ++ E + P +E LK++ +++G +
Sbjct: 1517 IVPAT---PSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSQL 1573
Query: 753 ILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKV-KDEGVYTLKAE 808
+ + GNP P I W KN+ P K + +G + V +D YT A
Sbjct: 1574 EMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAI 1633
Query: 809 NSEGIAETSAVITVE-EPTEENAEPPLFINR 838
N G T + VE E E E L I R
Sbjct: 1634 NKAGRDTTRCKVNVEVEFAEPEPERKLIIPR 1664
Score = 84.6 bits (200), Expect = 3e-15
Identities = 70/270 (25%), Positives = 116/270 (42%), Gaps = 25/270 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +++L+P G +F + G P+P+I+W+++ ++ + +D TL+
Sbjct: 3239 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEY-TLL 3297
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP-LSDHGSEMTVXXXXXXXXXXXXADI 628
+ E FPEDA +TC AKN G A+++ L VE P + EM V
Sbjct: 3298 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPV--------------- 3342
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
PP + EG +CR V+ + ++W K ++I P + D
Sbjct: 3343 ---YPPAIITPLQDTVTSEGQPARFQCR-VSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT 3398
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ L+I EGTYT VA N G+ S L ++ E + IE M +++
Sbjct: 3399 YQ----LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKE 3454
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKAL 778
S LSA+ G + K N+ ++ L
Sbjct: 3455 FSSSFLSAEEEGLHSAELQLSKINETLELL 3484
Score = 83.0 bits (196), Expect = 1e-14
Identities = 51/198 (25%), Positives = 92/198 (46%), Gaps = 3/198 (1%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
++ G +V L + Y+ P+P+ W+ + +K+ + + S +L+IK + G Y
Sbjct: 28502 VRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKY 28561
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKP-NILEIDSSSINICWDEPENTGNSTIIYYVV 1417
+ L+N V + V L PS P P EI + S+ + WD PE+ G I Y +
Sbjct: 28562 TVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSI 28621
Query: 1418 EYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
E +E T W V ++ +T + NL ++ Y+FR A N +S + +
Sbjct: 28622 EKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL-VSSIIVAKHQ 28680
Query: 1477 TKIQSPTVEKPLKNITTE 1494
+I P + + N+T++
Sbjct: 28681 FRIPGPPGKPVIYNVTSD 28698
Score = 81.0 bits (191), Expect = 4e-14
Identities = 65/245 (26%), Positives = 104/245 (42%), Gaps = 31/245 (12%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
E+ P+FV K +G T +F+ +V G P P+ WF I ++ +D
Sbjct: 1452 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1511
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I P D+G +T VA+N AG +S + L VEA
Sbjct: 1512 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA---------------------- 1549
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
+ + P F +K K + EGS + ++ R P PDI WL + IVP + + I
Sbjct: 1550 ---VEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRI 1606
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + LKI + YT A+N+ G + + ++ EP EP + +
Sbjct: 1607 EGTKGE--AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP----EPERKL 1660
Query: 745 IVRQG 749
I+ +G
Sbjct: 1661 IIPRG 1665
Score = 79.4 bits (187), Expect = 1e-13
Identities = 94/421 (22%), Positives = 165/421 (39%), Gaps = 35/421 (8%)
Query: 1074 LYIRNTSVHDEGEYSCILRDESC----TAEVTVVELPPEIITR-LQNQKVNKGNKAT-FE 1127
+ I+N +G YS + ++E+ T V V+++P + T L + N+ K T F
Sbjct: 17507 MVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFS 17566
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
E G + + + E +T +Q + L Y +
Sbjct: 17567 PEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQG--LIQGKAYFFRIAAENSIG 17624
Query: 1188 ILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW-------------YKKKS 1234
+ E S +R P I VP + E+ T+ +TW Y +S
Sbjct: 17625 MGPFVETSEALVIREP--ITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLES 17682
Query: 1235 VIEDTEKFTLISD--VKKRTLIIRKCTEDDQCEYTCVLLDAKS-------TTKLKVEVVE 1285
+ TEKF +++ + R ++ E D EY ++ T + +
Sbjct: 17683 RLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDEL 17742
Query: 1286 FPPKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
PP + +D+ + I+ G L Y P+P W + + + T + +
Sbjct: 17743 APPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLA 17802
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDE 1403
L K + +D+G Y + +EN+ G V ++D+P PP G + E+ + I W
Sbjct: 17803 LEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKP 17862
Query: 1404 PENTGNSTIIYYVVEYQEIDTTEWISVKNIT-KTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
P + G S I Y++E +E+ W+ V + + KT + L Y FR +A N IS
Sbjct: 17863 PLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGIS 17922
Query: 1463 D 1463
D
Sbjct: 17923 D 17923
Score = 78.6 bits (185), Expect = 2e-13
Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 6/187 (3%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK--SASLTIKKVENTDAG 1356
+K G + L + P P W + + + ID++ S+ ++ K + +D G
Sbjct: 19140 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 19199
Query: 1357 IYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
Y + N G V +LDKP P I+++ S +CWD PE+ G I Y+
Sbjct: 19200 KYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYI 19259
Query: 1417 VEYQEIDTTEWISVKNITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+E E W + T T++ L + Y FR A N++ TE VI
Sbjct: 19260 LEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKI---GTGPPTESKPVIA 19316
Query: 1476 ETKIQSP 1482
+TK P
Sbjct: 19317 KTKYDKP 19323
Score = 77.0 bits (181), Expect = 7e-13
Identities = 124/586 (21%), Positives = 227/586 (38%), Gaps = 62/586 (10%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
+K K V E EC + P + WL G EI E + ++ +H L
Sbjct: 2885 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ----LI 2939
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
I N YT V N + A+L + P + LK + + +++
Sbjct: 2940 IMNTSTEDSAEYTFVCGNDQVSATLTVT---------PIMITSMLKDINAEEKDTITFEV 2990
Query: 757 QVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
V + W KN +K+ ++ THS+ I + D YT A G
Sbjct: 2991 -TVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNI-RNVHFGDAADYTFVA----GK 3044
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A ++A + VE E F ++I V EK V+ P ++ W ++++ +
Sbjct: 3045 ATSTATLYVEARHIE------FRKHIKDIKVLEKKRAMFECEVSE-PDITVQWMKDDQEL 3097
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ I + L+I + D+G Y VA + A++ ++ V ++
Sbjct: 3098 QITDRIKIQKEKYVHRLLIPSTRMS-DAGKYTVVAGGNVST----AKLFVEGRDVR-IRS 3151
Query: 934 LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGM--DHREIIQEGRXXXXXXXXXX 990
++K + E + ++E + + V WY + EI+ + + + E R
Sbjct: 3152 IKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETR 3211
Query: 991 XXDVGVIKCIV-KDQETSTMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVV 1048
D G + +++ + T+ V P+ +++LQ V+ K V +
Sbjct: 3212 QSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKIS 3271
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE------SCTAEVTV 1102
W ++ +++ K F G L + D Y+C +++ S + V V
Sbjct: 3272 WYKEEQLLSTGF-KCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEV 3330
Query: 1103 VEL----------PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
E+ PP IIT LQ+ ++G A F+ ++ D V W+ +I+ S
Sbjct: 3331 PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFF 3390
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEY----SCEVGNSKCTAILTVEEP 1194
++T +L+I + +D G Y S VG TA L++E P
Sbjct: 3391 RMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAP 3436
Score = 76.2 bits (179), Expect = 1e-12
Identities = 64/231 (27%), Positives = 104/231 (45%), Gaps = 35/231 (15%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ--DFQMYYDDDN 564
+ AP F + L+ +GST FE + G+P P+++WFR +I S Q+ + D
Sbjct: 3 TQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
A L I V ++G ++ A N +G A+ST +E+ V
Sbjct: 63 -AKLTIPAVTKANSGRYSLKATNGSGQATST-------------AELLVKA--------- 99
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
E PP F ++ ++ V +GS + L+ R+ IP P + + G EI + ++
Sbjct: 100 -----ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQ 154
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP 735
E D++ L I GTY+V A N G A+ L ++ GE+E P
Sbjct: 155 EGDLYS----LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ-GEEEVP 200
Score = 76.2 bits (179), Expect = 1e-12
Identities = 55/212 (25%), Positives = 94/212 (44%), Gaps = 9/212 (4%)
Query: 1288 PKIVDYEREYR----IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
P IV++ EY IK G + + Q P P W + I+K + + + S
Sbjct: 28882 PPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGST 28941
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP-PGKPNILEIDSSSINICWD 1402
SL ++ G+Y + +N G A E+ V + D P G I + + WD
Sbjct: 28942 SLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWD 29001
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQ--TSIQNLKTNSSYRFRAYAVNEVD 1460
P N G + I +Y++E +E W +++ + Q T+I+ + N Y+FR AVN+
Sbjct: 29002 APLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGN-EYQFRVSAVNKFG 29060
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNIT 1492
+ ++ I+ T +P + +P NIT
Sbjct: 29061 VGRPLDSDPVVAQIQYTVPDAPGIPEP-SNIT 29091
Score = 73.7 bits (173), Expect = 6e-12
Identities = 41/112 (36%), Positives = 60/112 (53%), Gaps = 2/112 (1%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
++P P E P + L+ T +G +F+C+V G +++W+ + IKPS
Sbjct: 3329 EVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPS 3387
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ F+M +D L I E +PED GT+T VA NA G SST L +EAP S
Sbjct: 3388 RFFRMTQFEDTYQ-LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPES 3438
Score = 73.3 bits (172), Expect = 9e-12
Identities = 54/205 (26%), Positives = 92/205 (44%), Gaps = 13/205 (6%)
Query: 476 DENNYTQYLQ-KKLNEKIDKL---PVFE-KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFE 530
+E ++ LQ K+NE ++ L PV+ K SE++ PIF++++ G
Sbjct: 3464 EEGLHSAELQLSKINETLELLSESPVYSTKFDSEKEGTGPIFIKEVSNADISMGDVATLS 3523
Query: 531 CQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
V G P+P+I WF ++ PS D++ +D D+ +L+I ED G +TC+A N G
Sbjct: 3524 VTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDD-HSLIILFTKLEDEGEYTCMASNDYG 3582
Query: 591 FASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEG-IPPTFSKKPKAQYVDEGS 649
+ L + + H T + L G PP F K+ K +G
Sbjct: 3583 KTICSAYLKINSKGEGHKDTET------ESAVAKSLEKLGGPCPPHFLKELKPIRCAQGL 3636
Query: 650 DILLECRLVAIPEPDIAWLFKGEEI 674
+ E +V P P + W + +++
Sbjct: 3637 PAIFEYTVVGEPAPTVTWFKENKQL 3661
Score = 72.9 bits (171), Expect = 1e-11
Identities = 80/324 (24%), Positives = 121/324 (37%), Gaps = 30/324 (9%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
DEG+ + V + E + E I IE +M + S +
Sbjct: 3410 DEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHS 3469
Query: 706 GTYTVVAVNREGE--ASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILSAQVVGN 761
+ +N E + P+ EKE P I+ + + + G+ LS V+G
Sbjct: 3470 AELQLSKINETLELLSESPVYSTKFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGI 3529
Query: 762 PRPTITWCKNN---KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P+P I W N P DGD HS+ IL K ++DEG YT A N G SA
Sbjct: 3530 PKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILFTK-LEDEGEYTCMASNDYGKTICSA 3588
Query: 819 VITVEEPTEENAE------------------PPLFINRFQEITVKEKGTIKLVARVTRNP 860
+ + E + + PP F+ + I + V P
Sbjct: 3589 YLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEP 3648
Query: 861 VPSITWYRNNEIISPS--ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P++TW++ N+ + S TI N +G I N DSG Y C A N G+S+
Sbjct: 3649 APTVTWFKENKQLCTSVYYTIIHNPNGSG--TFIVNDPQREDSGLYICKAENMLGESTCA 3706
Query: 919 ARVTIDVEKVTFVKHLQKSYETEE 942
A + + +E K+ T E
Sbjct: 3707 AELLVLLEDTDMTDTPCKAKSTPE 3730
Score = 72.9 bits (171), Expect = 1e-11
Identities = 64/217 (29%), Positives = 88/217 (40%), Gaps = 28/217 (12%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
EG P F K+ + G L ++ IP+P I W F G + P + + D H
Sbjct: 3499 EGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDH 3558
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT---GEKE------------- 733
L I K EG YT +A N G+ LKI + G K+
Sbjct: 3559 S----LIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEK 3614
Query: 734 -----PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV--KALPTKSDGDT 786
PP ++ LK + QG I VVG P PT+TW K NK + T
Sbjct: 3615 LGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPN 3674
Query: 787 HSIT-ILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
S T I+ + +D G+Y KAEN G + +A + V
Sbjct: 3675 GSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3711
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 1/96 (1%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
++ P FV++L+ GS V+ + +V G P P + ++R A I+ S DFQ+ + D +
Sbjct: 100 ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD-L 158
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+L+I E +PED+GT++ A N+ G A+ST EL+V+
Sbjct: 159 YSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 72.1 bits (169), Expect = 2e-11
Identities = 64/298 (21%), Positives = 122/298 (40%), Gaps = 11/298 (3%)
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTL 1244
TA VE P I+ + + I+V A L ++ + L + W + IE++ + +
Sbjct: 24542 TAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEI 24601
Query: 1245 ISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFP-PKIVDYEREYRIKR 1301
+ K LI++ D +Y + + + V+V++ P P +
Sbjct: 24602 KNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSE 24661
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
+T Q ++V + + T + + + SL + K+ + ++++
Sbjct: 24662 KCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIM 24721
Query: 1362 LENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
N G + + +L K P PP + I S+ +CW+ P++ G S II Y+
Sbjct: 24722 AVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 24781
Query: 1417 VEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
VE ++ WI + + IT + + L + Y FR A N + + S T YYK
Sbjct: 24782 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYK 24839
Score = 69.3 bits (162), Expect = 1e-10
Identities = 36/95 (37%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 510 PIFVEKLRP-KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
P FV+KL K G ++Q EC++ G P +++WFR + + S + M + + +VA L
Sbjct: 7291 PKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFIN-SVALL 7349
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
I E ED+G + C A N G AS +T L V+AP
Sbjct: 7350 TINEASAEDSGDYICEAHNGVGDASCSTALTVKAP 7384
Score = 69.3 bits (162), Expect = 1e-10
Identities = 54/172 (31%), Positives = 90/172 (52%), Gaps = 16/172 (9%)
Query: 678 ENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---P 734
E S+ ES + C+ + +T + QE + V A N +G++ P VL + K+
Sbjct: 25184 EKWSIVAESKV---CNAV-VTGLSSGQEYQFRVKAYNEKGKSD-PRVLGVPVIAKDLTIQ 25238
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P + P + ++ GE + + V+G PRP I+W K+ +P+K + +T + T+L
Sbjct: 25239 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHI 25298
Query: 795 KK-VKDE-GVYTLKAENSEGIA-ETSAVITVEEPTEENAEPPLFINRFQEIT 843
K+ KD+ G YT+ A NS G A E +VI +E+P PP+ RF E++
Sbjct: 25299 KEGNKDDFGKYTVTATNSAGTATENLSVIVLEKP-----GPPVGPVRFDEVS 25345
Score = 68.5 bits (160), Expect = 2e-10
Identities = 40/163 (24%), Positives = 79/163 (48%), Gaps = 12/163 (7%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASL-----TIKKVENTDAGIYKLRLENNCGHA 1369
P+ + + + I++KC+ + + SA++ T+ ++ + I+++R EN G
Sbjct: 19247 PEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTG 19306
Query: 1370 DVEMNVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
+ ++ DKP P P + ++ + + W+ PE G +I Y +E +E +
Sbjct: 19307 PPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHS 19366
Query: 1425 TEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
T W+ V I + + +QNL + Y+FR A NE+ I + S
Sbjct: 19367 TRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPS 19409
Score = 67.3 bits (157), Expect = 6e-10
Identities = 69/297 (23%), Positives = 126/297 (42%), Gaps = 18/297 (6%)
Query: 1187 AILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLI 1245
A+ T E P I ++L + V A T L + + +TW K +++ ++ T+
Sbjct: 14608 AVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIE 14667
Query: 1246 SDVKKRTLIIRKCTEDDQCEYT--CVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGS 1303
+ KK T+ I D Y V + ++T ++V V++ P ++ I +
Sbjct: 14668 NVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFD----ITDVT 14723
Query: 1304 DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT----KPSIDSKSASLTIKKVENTDAGIYK 1359
+ + L+ + I N + ++ + K S K + K+ I++
Sbjct: 14724 NESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFR 14783
Query: 1360 LRLENNCGHAD-VEMN-VTILDKPSPPGKPNILE---IDSSSINICWDEPENTGNSTIIY 1414
+ EN G + V+ + +T + PPG P LE I ++ + W EP++ G S I
Sbjct: 14784 VAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITG 14843
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
Y VE + DT +W+ + T+ ++ L YRFR A N S++TE
Sbjct: 14844 YWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTE 14900
Score = 67.3 bits (157), Expect = 6e-10
Identities = 62/257 (24%), Positives = 110/257 (42%), Gaps = 16/257 (6%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEF 1286
++W K ++++E K TL I+ ++ +YT +L +A + + V+
Sbjct: 28522 ISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITL 28581
Query: 1287 -PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK--CKHTKPSIDSKSA 1343
PP + + V L D P+ N + I+K T + S
Sbjct: 28582 GPPSKPKGPIRFDEIKADSVILSWD---VPEDNGGGEITCYSIEKRETSQTNWKMVCSSV 28638
Query: 1344 SLTIKKVEN--TDAGI-YKLRLENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSS 1395
+ T KV N DA +++R EN G + ++ I+ K P PPGKP I + S
Sbjct: 28639 ARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSD 28698
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKTQTSIQNLKTNSSYRFRA 1453
+++ WD P G S + + VE +E ++ W ++ I+ + L Y+FR
Sbjct: 28699 GMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRV 28758
Query: 1454 YAVNEVDISDASETTEY 1470
YA N +S S+ +++
Sbjct: 28759 YAENSAGLSSPSDPSKF 28775
Score = 66.1 bits (154), Expect = 1e-09
Identities = 37/104 (35%), Positives = 56/104 (53%), Gaps = 2/104 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE +++ F +++ +G V F C++ GYP P+I W++ IK + +QM +
Sbjct: 1284 SESEAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQ 1343
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE--APL 604
D A+L I V PED G +T A N G A + +L VE APL
Sbjct: 1344 DGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPL 1387
Score = 65.7 bits (153), Expect = 2e-09
Identities = 54/185 (29%), Positives = 83/185 (44%), Gaps = 9/185 (4%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNK-YDFEKRGHIRKL 1074
P F + LQ V E A E I+ +V W RDG++I KL
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1075 YIRNTSVHDEGEYSCILRDES----CTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEI 1128
I + + G YS + S TAE+ V PP + RLQ+ V +G++ ++
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 1129 ELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
+T +V++++DG+EIQ S Q++ +G L I + +D+G YS NS A
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 1188 ILTVE 1192
T E
Sbjct: 186 TSTAE 190
Score = 63.7 bits (148), Expect = 7e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 2/110 (1%)
Query: 495 LPVFEKPTSE-EQSM-APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKP 552
+P F+ E SM AP E+++ + GS F +V G P P+ W++ I+
Sbjct: 2061 IPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIER 2120
Query: 553 SQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
S Y+ +DNV LVIR+V ED+ + A N AG SS L+V+A
Sbjct: 2121 SDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2170
Score = 62.9 bits (146), Expect = 1e-08
Identities = 62/302 (20%), Positives = 121/302 (40%), Gaps = 13/302 (4%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVV 1284
V+W+K ++ +++ T+ +D L + K D YT L + +T + V+V+
Sbjct: 15345 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVI 15404
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P D + K +T P +++ + + + S
Sbjct: 15405 GLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLS 15464
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHAD-VEMNVTIL--DKPSPPGKPNILEIDS---SSIN 1398
T+K + ++++ N G + +E+ ++ D PP P +E+ + ++
Sbjct: 15465 WTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMT 15524
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQT-SIQNLKTNSSYRFRAYAV 1456
I W P G S I+ Y++E W +++ T + + L+ Y+FR A
Sbjct: 15525 ITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAE 15584
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY 1516
N IS+ S T K + I +P V ++ + ++I L G P P +TW
Sbjct: 15585 NAAGISEPSRATPPTKAV--DPIDAPKVIL-RTSLEVKRGDEIALDASISGSPYPTITWI 15641
Query: 1517 RD 1518
+D
Sbjct: 15642 KD 15643
Score = 60.9 bits (141), Expect = 5e-08
Identities = 60/267 (22%), Positives = 107/267 (40%), Gaps = 14/267 (5%)
Query: 1216 LTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ ++I + ++WYK +E ++KF + D + TL ++ C DQ Y V
Sbjct: 9604 IDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVC--GPH 9661
Query: 1276 TTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
K+ V+E P + ++ +K G T+ + P EW N +I+K K
Sbjct: 9662 IASAKLTVIE--PAWERHLQDVTLKEGQTCTMTCQFSV-PNVKSEWFRNGRILKPQGRHK 9718
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP-PGKPNILEIDS 1394
++ K LTI V D G Y C + D+E + + + P I I
Sbjct: 9719 TEVEHKVHKLTIADVRAEDQGQY------TCKYEDLETSAELRIEAEPIQFTKRIQNIVV 9772
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQ-TSIQNLKTNSSYRFRA 1453
S E E + + I+ + E+ ++ + +N + +I N+ + +
Sbjct: 9773 SEHQSATFECEVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSV 9832
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQ 1480
A E +A T E Y KE K++
Sbjct: 9833 IARLE-PRGEARSTAELYLTTKEIKLE 9858
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 2/126 (1%)
Query: 475 MDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVE 534
+D N+ +Y+ K N + ++ T +EQ + P F +LR G V F+C +
Sbjct: 8950 VDINDSGEYICKAENS-VGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAIS 9008
Query: 535 GYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASS 594
G ++W++ +K S + Q + DN ATL I + AG ++C A N G ASS
Sbjct: 9009 GSEPISVSWYKDGKPLKDSPNVQTSF-LDNTATLNIFKTDRSLAGQYSCTATNPIGSASS 9067
Query: 595 TTELIV 600
+ LI+
Sbjct: 9068 SARLIL 9073
Score = 58.8 bits (136), Expect = 2e-07
Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 16/157 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA-----SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
ITN+ + +E + VVAVN +G + ++PIV K E P V S V+ G+
Sbjct: 24117 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIE---PDVKPAFSSYSVQVGQD 24173
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV-KDE-GVYTLKAEN 809
+ + + G P+PTITW K+ P+K + D+ +T L K+ KD+ G Y + N
Sbjct: 24174 LKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVAN 24233
Query: 810 SEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVK 845
G S ++T+++P +PP +F +++ +
Sbjct: 24234 VVGQKTASIEIVTLDKP-----DPPKGPVKFDDVSAE 24265
Score = 58.4 bits (135), Expect = 3e-07
Identities = 45/148 (30%), Positives = 70/148 (47%), Gaps = 8/148 (5%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---PPQVIEPLKSMIVRQGES 751
L +T +K+ ++ + V A N G SLP + KE PP+++ P + + ++ G+
Sbjct: 19785 LVVTGLKEGKKYKFRVAARNAVG-VSLPREAEGVYEAKEQLLPPKILMP-EQITIKAGKK 19842
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKS--DGDTHSITILKPKKVKDEGVYTLKAEN 809
+ + A V G P PT W K V + D+ SI I+K KD G Y+L AEN
Sbjct: 19843 LRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAEN 19902
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFIN 837
S G +T + V +PP I+
Sbjct: 19903 SSG-TDTQKIKVVVMDAPGPPQPPFDIS 19929
Score = 57.6 bits (133), Expect = 5e-07
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 7/197 (3%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------ATYENRX 1533
Q+PT +PL+++ G P P+V+W+RDG+ + T+ + + R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDEWLV 1592
Y A N G+ ++ + ++ + + ++ + G + +
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ GIP P V +Y++G ++++ ++ I+ + + I E S Y++ A+N+ G
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 1653 TSSVEVTLKVYDKPSKP 1669
++ L V + P
Sbjct: 184 RATSTAELLVQGEEEVP 200
Score = 57.6 bits (133), Expect = 5e-07
Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E+ + AP F+ K + +G +V F CQV G P+P + W + + +++
Sbjct: 1071 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKV 1130
Query: 559 YYD-DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
Y+ LVI F +DAG +T V +N G S++ L+ EA
Sbjct: 1131 SYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEA 1175
Score = 57.2 bits (132), Expect = 6e-07
Identities = 26/91 (28%), Positives = 48/91 (52%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++L+P G FE V G P P +TWF++ + S + + ++ + T +
Sbjct: 3621 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFI 3680
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ + ED+G + C A+N G ++ EL+V
Sbjct: 3681 VNDPQREDSGLYICKAENMLGESTCAAELLV 3711
Score = 56.8 bits (131), Expect = 8e-07
Identities = 44/153 (28%), Positives = 76/153 (49%), Gaps = 10/153 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA----SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ N+ + +E T+ V+AVN G + S P+++K +T E K +I + G+++
Sbjct: 21951 VRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNI 22010
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAENS 810
+ V+G P+PT+TW K ++ +K + T + TIL + D G Y L A N
Sbjct: 22011 KVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNI 22070
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G E VIT++ + PP +F E++
Sbjct: 22071 VG--EVGDVITIQ--VHDIPGPPTGPIKFDEVS 22099
Score = 56.4 bits (130), Expect = 1e-06
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 5/136 (3%)
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A+ + V P E PP ++ + +TV E ++ L ++ P P++TWYR + I
Sbjct: 924 AKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQI 983
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
S F L+I +E DSG + C A N AG S + + V + F K
Sbjct: 984 ESSIDFQITFQSGIARLMIREAFAE-DSGRFTCSAVNEAGTVSTSCYLAVQVSE-EFEKE 1041
Query: 934 ---LQKSYETEEGKTV 946
+ + + TEE + V
Sbjct: 1042 TTAVTEKFTTEEKRFV 1057
Score = 56.4 bits (130), Expect = 1e-06
Identities = 29/100 (29%), Positives = 49/100 (49%), Gaps = 1/100 (1%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
+E+ + P F +L+ G V C++ G Q+ W+R +++ ++ Q + D
Sbjct: 7096 QERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVD- 7154
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
NVATL I + +G ++C A N G ASS+ L P
Sbjct: 7155 NVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREP 7194
Score = 56.0 bits (129), Expect = 1e-06
Identities = 30/101 (29%), Positives = 53/101 (52%), Gaps = 1/101 (0%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
++ +AP F + LR + T + +C++ G +++WF+ I S +++ + +
Sbjct: 5035 DRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGT 5094
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +IR V DAG FTC A N+ G S+ LIV+ P S
Sbjct: 5095 ASLEIIR-VDMNDAGNFTCRATNSVGSKDSSGALIVQEPPS 5134
Score = 55.6 bits (128), Expect = 2e-06
Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENR 1532
E + PT+ LKN+T E + L C G P P VTWYR+ +++++ + T+++
Sbjct: 937 EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG 996
Query: 1533 -XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+ C A N+ G V TSC + +Q
Sbjct: 997 IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033
Score = 54.4 bits (125), Expect = 4e-06
Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
++++ P F +L+ G++ EC+V G + WF + I +Q + D N
Sbjct: 6722 DRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSD-N 6780
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
V TL + + D G +TCVA N AG L V+ P S
Sbjct: 6781 VCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPS 6821
Score = 53.6 bits (123), Expect = 7e-06
Identities = 27/100 (27%), Positives = 48/100 (48%), Gaps = 2/100 (2%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
T +++ P V P +G T +F C+V GYP+P++ W+ +I+ S+ F++ Y
Sbjct: 1833 TDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY- 1891
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
D + L I + D G A+N G +L ++
Sbjct: 1892 -DGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1930
Score = 53.6 bits (123), Expect = 7e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 12/151 (7%)
Query: 686 SDMHMYCSVLKITNVK-----KFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---PPQV 737
SD C+ +K+T + +E ++ V A N +G S P L + K+ PP
Sbjct: 23019 SDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKG-ISDPRQLSVPVIAKDLVIPPAF 23077
Query: 738 IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV 797
+ V GE + + +G P P +TW K+N P+K + T + ++L K
Sbjct: 23078 KLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDA 23137
Query: 798 --KDEGVYTLKAENSEGIA-ETSAVITVEEP 825
+D G Y +K NS G A ET VI +++P
Sbjct: 23138 CREDVGHYVVKLTNSAGEAIETLNVIVLDKP 23168
Score = 52.4 bits (120), Expect = 2e-05
Identities = 31/130 (23%), Positives = 65/130 (50%), Gaps = 3/130 (2%)
Query: 475 MDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPK-HTPDGSTVQFECQV 533
+D+ + QY +NE + K + +E+ + P F ++L +G++ + E +V
Sbjct: 9142 VDKGDSGQYTCYAVNE-VGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRV 9200
Query: 534 EGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFAS 593
G + W++ I+P+ + ++ + + N L +R+ DAG +TC N AG A
Sbjct: 9201 AGSQPITVAWYKNNIEIQPTSNCEITFKN-NTLVLQVRKAGMNDAGLYTCKVSNDAGSAL 9259
Query: 594 STTELIVEAP 603
T+ ++++ P
Sbjct: 9260 CTSSIVIKEP 9269
Score = 51.6 bits (118), Expect = 3e-05
Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 5/116 (4%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT--I 791
PP ++ LK++ V +GESV L + G P PT+TW + + +++ I +
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 1001
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
++ +D G +T A N G TS + V+ E E +F T +EK
Sbjct: 1002 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKF---TTEEK 1054
Score = 51.6 bits (118), Expect = 3e-05
Identities = 35/117 (29%), Positives = 59/117 (50%), Gaps = 10/117 (8%)
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKSMI-VRQGESVILSAQV 758
+F+ T V ++ E S P+ + E PP++ +KS++ V+ G +V L A V
Sbjct: 20190 QFRAIARTAVNISPPSEPSDPVTI---LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 20246
Query: 759 VGNPRPTITWCKNN---KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
G P PT++W K+ KP + + + ++ + + KD G YT+ AENS G
Sbjct: 20247 FGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNR-KDSGDYTITAENSSG 20302
Score = 50.8 bits (116), Expect = 5e-05
Identities = 40/140 (28%), Positives = 71/140 (50%), Gaps = 14/140 (10%)
Query: 696 KITNVKKFQEGTYTVVAVNREGE---ASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQG 749
K+T ++ Q + V+AVN GE A +P + +K EPP++I + ++ G
Sbjct: 18102 KVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKD-RLEPPELILDANMAREQHIKVG 18160
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI---TILKPKKVKDEGVYTLK 806
+++ LSA + G P P +TW K ++ PTK+ D + ++ +D G+Y+L
Sbjct: 18161 DTLRLSAIIKGVPFPKVTWKKEDRDA---PTKARIDVTPVGSKLEIRNAAHEDGGIYSLT 18217
Query: 807 AENSEGIAETSA-VITVEEP 825
EN G S V+ +++P
Sbjct: 18218 VENPAGSKTVSVKVLVLDKP 18237
Score = 50.8 bits (116), Expect = 5e-05
Identities = 38/149 (25%), Positives = 69/149 (46%), Gaps = 8/149 (5%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLK--IKTGEKEPPQVIE--P--LKSMIVRQGE 750
+T + + ++A N G S P I T ++ P ++E P +I++ GE
Sbjct: 28842 VTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGE 28901
Query: 751 SVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSITILKPKKVKD-EGVYTLKAE 808
S+ + A V G P P +TW K+ + K + + S ++ +D GVYT++A+
Sbjct: 28902 SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAK 28961
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFIN 837
N+ G A+ + V++ + P F N
Sbjct: 28962 NASGSAKAEIKVKVQDTPGKVVGPIRFTN 28990
Score = 50.4 bits (115), Expect = 7e-05
Identities = 73/330 (22%), Positives = 129/330 (39%), Gaps = 42/330 (12%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E + F + K + EG + C++ P P IAW G+ I E + D
Sbjct: 1287 EAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGR 1346
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+ L+I V EG YT A N +G A I +G+ +EP +
Sbjct: 1347 ---ASLRIPVVLPEDEGIYTAFASNIKGNA-------ICSGKL----YVEPAAPL---GA 1389
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ I + + V R + P++ P + + P ++ + +
Sbjct: 1390 PTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR----------MSPARMSPARMSPARMSP 1439
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ ET +E E P+F+ + E T + +V P+P W+ +
Sbjct: 1440 GRRLEET------DESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHD 1493
Query: 870 NEIISPSET--ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID-VE 926
+ I T + DG +++ S DSG++ VA N AG+SS +T++ VE
Sbjct: 1494 GQQIVNDYTHKVVIKEDGTQSLIIVPATPS--DSGEWTVVAQNRAGRSSISVILTVEAVE 1551
Query: 927 ---KVTFVKHLQKSYETEEGKTVILECQTS 953
K FV+ L K+ +EG + ++ + +
Sbjct: 1552 HQVKPMFVEKL-KNVNIKEGSQLEMKVRAT 1580
Score = 50.0 bits (114), Expect = 9e-05
Identities = 54/226 (23%), Positives = 96/226 (42%), Gaps = 22/226 (9%)
Query: 705 EGTYTVVAVNREGEA--SLP---IVLKIKTGEKEPPQVIEPLKSMIV-------RQGESV 752
E ++ + A+N+ G + S P + ++ P+VI+ KS + G S
Sbjct: 20088 EYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSK 20147
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
I+ V P W + N +P + ++ T L+ K A N
Sbjct: 20148 IIGYFVEACKLPGDKWVRCNTAPHQIPQEE----YTATGLEEKAQYQFRAIARTAVNISP 20203
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQE--ITVKEKGTIKLVARVTRNPVPSITWYRNN 870
+E S +T+ EN P + ++ + +TVK + L A V P+P+++W ++
Sbjct: 20204 PSEPSDPVTI---LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDG 20260
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
++ P+E I L + +V+ + DSGDY A NS+G S
Sbjct: 20261 TLLKPAEGIKMAMQRNLCTLELFSVNRK-DSGDYTITAENSSGSKS 20305
Score = 49.6 bits (113), Expect = 1e-04
Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 3/118 (2%)
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+ E E +A A+ V +E +P + + + + V E T + RVT P P +
Sbjct: 1815 RIEELERMAHEGALTGVTTDQKEKQKPDIVLYP-EPVRVLEGETARFRCRVTGYPQPKVN 1873
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
WY N ++I S+ +DG + L I + S D+G+ K A N G H ++ I
Sbjct: 1874 WYLNGQLIRKSKRFRVRYDGIHY-LDIVDCKS-YDTGEVKVTAENPEGVIEHKVKLEI 1929
Score = 49.6 bits (113), Expect = 1e-04
Identities = 44/129 (34%), Positives = 62/129 (48%), Gaps = 13/129 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-----VRQGES 751
+ N+ + Q + V AVN GE+ + L + + E P I+ S+ V+ GE
Sbjct: 16283 VENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEP 16342
Query: 752 VILSAQVVGNPRPTITWCKN----NKPVKALP-TKSD-GDTHSITILK-PKKVK-DEGVY 803
V + A V G P P I W KN KP AL TK + + + T L PK V+ D+G Y
Sbjct: 16343 VHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTY 16402
Query: 804 TLKAENSEG 812
T+ A N G
Sbjct: 16403 TVTASNRLG 16411
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPP---LFINRFQEITVKEKGTIKLVARVTRN 859
+ +KAEN G+ I +E +E PP L + + + VK T++ A +
Sbjct: 18407 FRVKAENIVGLGLPDTTIPIE--CQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGV 18464
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
PVP+ W + I E T D + L I N D+G+Y+ SN+AG +
Sbjct: 18465 PVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRR-DTGEYQITVSNAAGSKTVAV 18523
Query: 920 RVTI 923
+T+
Sbjct: 18524 HLTV 18527
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/130 (26%), Positives = 66/130 (50%), Gaps = 11/130 (8%)
Query: 691 YCSVLKITNVKKFQEGTYTVVA---VNREGEASLPIVLKIKTGEKEPPQVIEPLKS---M 744
Y V ++T ++++ + A V+ E++ PI++K + EPP+V+ +K +
Sbjct: 26670 YFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVK---DDVEPPRVMMDVKFRDVI 26726
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPV--KALPTKSDGDTHSITILKPKKVKDEGV 802
+V+ GE + ++A + G P P I+W K+ + +A D H++ +K +D G
Sbjct: 26727 VVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQ 26786
Query: 803 YTLKAENSEG 812
Y L +N G
Sbjct: 26787 YVLTLKNVAG 26796
Score = 48.8 bits (111), Expect = 2e-04
Identities = 42/198 (21%), Positives = 80/198 (40%), Gaps = 14/198 (7%)
Query: 1472 KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY-- 1529
K+ +++P + + +++ T D G P P+ WY++G K++ + Y
Sbjct: 2068 KIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWY 2127
Query: 1530 ---ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE--DIKQKH 1584
+N A N GE + + +Q K +IT + E D+ K
Sbjct: 2128 WPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKE 2187
Query: 1585 KVGDEWLVTAVIEGIPP-PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY 1643
K + + T E P +V WYK+G ++ +Y + + K + I + S + Y
Sbjct: 2188 K---DTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDY 2244
Query: 1644 T---IEASNTAGTSSVEV 1658
+ +E N T+ + V
Sbjct: 2245 SCVLVEDENVKTTAKLIV 2262
Score = 48.8 bits (111), Expect = 2e-04
Identities = 25/102 (24%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
TS + PIF +K P T G+ V EC+++G P ++W++ ++ + +++
Sbjct: 8318 TSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKI-MS 8376
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
++ + ++ I V D G + C A N G + + ++AP
Sbjct: 8377 ENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAP 8418
Score = 48.0 bits (109), Expect = 4e-04
Identities = 76/333 (22%), Positives = 128/333 (38%), Gaps = 34/333 (10%)
Query: 1090 ILRDESCTAEVTVVELP--PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEI 1146
++ D S T E P P IT+ QK+ +G F ++ V W K G +
Sbjct: 1063 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1122
Query: 1147 QFSNHIQLTIDGK--KQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTL 1200
+++ + + + KL I DDAGEY+ V G + +A L +EE +
Sbjct: 1123 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL-LEEADYELLM 1181
Query: 1201 RLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
+ + +L A++ ET Y + + E+ + + K T+++R E
Sbjct: 1182 KSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE 1241
Query: 1261 DDQ-------------CEYTCV------LLDAKSTTKLKVEVVEFPPKIVDYE---REYR 1298
D + EY + LL+ K+ V++ E ++ + YR
Sbjct: 1242 DQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDLRIKNYR 1301
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC-KHTKPSIDSKSASLTIKKVENTDAGI 1357
I G VT +P P W + K IK ++ + ASL I V D GI
Sbjct: 1302 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1361
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
Y N G+A + ++ +P G P +
Sbjct: 1362 YTAFASNIKGNA-ICSGKLYVEPAAPLGAPTYI 1393
Score = 48.0 bits (109), Expect = 4e-04
Identities = 54/243 (22%), Positives = 85/243 (34%), Gaps = 21/243 (8%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVE--GYPRPQITWFRQTAIIKPSQDFQMYYD 561
+E+ P F +KL FEC++ G P + W ++ + +M +
Sbjct: 1697 KEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMI-N 1755
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV--EAPLSDHGS---------- 609
+ +L + D+G TC A N G ++ LIV E L +
Sbjct: 1756 EFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQR 1815
Query: 610 -EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWL 668
E D E P P+ V EG CR+ P+P + W
Sbjct: 1816 IEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWY 1875
Query: 669 FKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
G+ I + V + +H L I + K + G V A N EG + L+I+
Sbjct: 1876 LNGQLIRKSKRFRVRYDG-IH----YLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1930
Query: 729 TGE 731
E
Sbjct: 1931 QRE 1933
Score = 48.0 bits (109), Expect = 4e-04
Identities = 24/77 (31%), Positives = 44/77 (57%), Gaps = 1/77 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+ V + V G P P ++W + ++KP++ +M N+ TL + V +D+G +T
Sbjct: 20237 GTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQR-NLCTLELFSVNRKDSGDYTI 20295
Query: 584 VAKNAAGFASSTTELIV 600
A+N++G S+T +L V
Sbjct: 20296 TAENSSGSKSATIKLKV 20312
Score = 47.6 bits (108), Expect = 5e-04
Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 1/101 (0%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
+Q++ P F +KL GS++ EC+V G WF+ I S +++ + +
Sbjct: 6159 DQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERS 6218
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
V +L + + ED +TC N AG + + L V+ P S
Sbjct: 6219 V-SLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPS 6258
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/68 (35%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P PE W+ +G ++ ND + + KE T + I S S ++T+ A N AG S
Sbjct: 1480 VVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRS 1539
Query: 1655 SVEVTLKV 1662
S+ V L V
Sbjct: 1540 SISVILTV 1547
Score = 47.2 bits (107), Expect = 6e-04
Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 9/158 (5%)
Query: 1229 WYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK----LKVEV 1283
W+ + ++ D +I + ++LII T D E+T V + + L VE
Sbjct: 1490 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA 1549
Query: 1284 VEFP--PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
VE P V+ + IK GS + + V P P+ W+ NS II K+ K I+
Sbjct: 1550 VEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGT 1609
Query: 1342 --SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
A+L I + D+ Y N G V +
Sbjct: 1610 KGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1647
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 2/95 (2%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA-IIKPSQDFQMYYDDDNVATL 568
P FV+KL T G V+ VEG+ + W + +I+ S++ ++ + D N+ATL
Sbjct: 7478 PRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFID-NIATL 7536
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ ++G + C KN AG + L V P
Sbjct: 7537 QLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEP 7571
Score = 46.8 bits (106), Expect = 9e-04
Identities = 33/124 (26%), Positives = 54/124 (43%), Gaps = 3/124 (2%)
Query: 477 ENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGY 536
E++ +Y+ + LN+ K K T +++ AP+ K+ P G +F C+++
Sbjct: 4352 EDHQGEYVCEALNDS-GKTATSAKLTVVKRA-APVIKRKIEPLEVALGHLAKFTCEIQSA 4409
Query: 537 PRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTT 596
P + WF+ I S D +++L I D G +TC A N G S T
Sbjct: 4410 PNVRFQWFKAGREIYES-DKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTA 4468
Query: 597 ELIV 600
L V
Sbjct: 4469 TLTV 4472
Score = 46.8 bits (106), Expect = 9e-04
Identities = 39/124 (31%), Positives = 57/124 (45%), Gaps = 6/124 (4%)
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQGESVILSAQVVG 760
+E V AVN G S P + K+P P + +IV +GE + +
Sbjct: 15281 KEYVLRVRAVNAIG-VSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRA 15339
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVK-DEGVYTLKAENSEGIAETSA 818
P PT++W K+ K VKA + + H S + PK V+ D G+YT+ EN G A S
Sbjct: 15340 VPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASI 15399
Query: 819 VITV 822
+ V
Sbjct: 15400 NVKV 15403
Score = 46.4 bits (105), Expect = 0.001
Identities = 39/149 (26%), Positives = 67/149 (44%), Gaps = 4/149 (2%)
Query: 803 YTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
+ +KA N EG A + + E L + ITV+ TI+++ARV P
Sbjct: 18804 FRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRP 18863
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
P ITW + +++ + + D +EL I D G Y A NS+G + A
Sbjct: 18864 EPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEA-VRADHGKYIISAKNSSGHAQGSAI 18922
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILE 949
V + +++ ++L+ + T+E T+ E
Sbjct: 18923 VNV-LDRPGPCQNLKVTNVTKENCTISWE 18950
Score = 46.4 bits (105), Expect = 0.001
Identities = 31/122 (25%), Positives = 59/122 (48%), Gaps = 5/122 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ + A N+ G++ V E E+ P + + ++IT+K +++ A V P P
Sbjct: 19798 FRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMP--EQITIKAGKKLRIEAHVYGKPHP 19855
Query: 863 SITWYR-NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
+ W + +E+++ S D +I L+I +V + DSG Y A NS+G + +V
Sbjct: 19856 TCKWKKGEDEVVTSSHLAVHKADSSSI-LIIKDVTRK-DSGYYSLTAENSSGTDTQKIKV 19913
Query: 922 TI 923
+
Sbjct: 19914 VV 19915
Score = 46.0 bits (104), Expect = 0.001
Identities = 28/121 (23%), Positives = 52/121 (42%)
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
KF+ + + GE + I +K + + ++V G + + A V G
Sbjct: 17419 KFRVSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGK 17478
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
P PT+TW N + + T S ++K + +GVY+L A+N G + + ++
Sbjct: 17479 PPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVD 17538
Query: 822 V 822
V
Sbjct: 17539 V 17539
Score = 46.0 bits (104), Expect = 0.001
Identities = 27/79 (34%), Positives = 42/79 (53%), Gaps = 2/79 (2%)
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKP-VKALPTKSDGDTHSITILKPKKVK-DEGVY 803
VR G+++ + A+V G P P ITW K K V+ D + + + V+ D G Y
Sbjct: 18847 VRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKY 18906
Query: 804 TLKAENSEGIAETSAVITV 822
+ A+NS G A+ SA++ V
Sbjct: 18907 IISAKNSSGHAQGSAIVNV 18925
Score = 45.6 bits (103), Expect = 0.002
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G+ + I G P P V WY+ ++E+ ++ IT + + + I+E S ++T
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 1647 ASNTAGTSSVEVTLKV 1662
A N AGT S L V
Sbjct: 1017 AVNEAGTVSTSCYLAV 1032
Score = 45.6 bits (103), Expect = 0.002
Identities = 40/182 (21%), Positives = 76/182 (41%), Gaps = 6/182 (3%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTH 787
EK+ P ++ + + V +GE+ +V G P+P + W N + + K + DG H
Sbjct: 1837 EKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IH 1895
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
+ I+ K D G + AEN EG+ E + +++ + + E V E
Sbjct: 1896 YLDIVDCKSY-DTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEP 1954
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCV 907
G ++ + PV + T + + +E IT E E + + + G Y+ +
Sbjct: 1955 GKLQFEVQKVDRPVDT-TETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 2013
Query: 908 AS 909
+
Sbjct: 2014 TA 2015
Score = 45.2 bits (102), Expect = 0.003
Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 1/102 (0%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
T+ E +P F K G + FEC V G +ITW + I+P ++ +
Sbjct: 7190 TAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITC- 7248
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
N L I +V D+G +TC A N G + +L V+ P
Sbjct: 7249 VGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEP 7290
Score = 45.2 bits (102), Expect = 0.003
Identities = 41/179 (22%), Positives = 80/179 (44%), Gaps = 14/179 (7%)
Query: 747 RQGESVILSAQVVGNPRPTITWCK-NNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+ G S I+ V P T W + N++P+K L K + + P K E V +
Sbjct: 15237 KNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEG------VVPDK---EYVLRV 15287
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVK-EKGTIKLVARVTRNPVPSI 864
+A N+ G++E S + + + +P + + I ++ EK +I + R PVP++
Sbjct: 15288 RAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAV--PVPTV 15345
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+W+++ + + S+ +T D + L + D+G Y N G ++ V +
Sbjct: 15346 SWHKDGKEVKASDRLTMKNDHISAHLEVPK-SVRADAGIYTITLENKLGSATASINVKV 15403
Score = 45.2 bits (102), Expect = 0.003
Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G+++ L+ + P P ++W G + P E I +A++ ++ C+ L++ +V +
Sbjct: 20234 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL---CT-LELFSVNRKD 20289
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV 737
G YT+ A N G S I LK+ P V
Sbjct: 20290 SGDYTITAENSSGSKSATIKLKVLDKPGPPASV 20322
Score = 45.2 bits (102), Expect = 0.003
Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 9/99 (9%)
Query: 731 EKEPPQV-IEPL--KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDG 784
E +PP++ ++P +++V GES + A + G P PTI W K ++ + L KS
Sbjct: 23464 EVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTD 23523
Query: 785 DTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
S+++ +V D G Y LKA+N G E S + V+
Sbjct: 23524 FATSLSVKDAVRV-DSGNYILKAKNVAG--ERSVTVNVK 23559
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/125 (24%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
+E + + A+N +GI++ ++V ++ PP F F TV +K+
Sbjct: 23042 EEYSFRVSAQNEKGISDPRQ-LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIG 23100
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P++TW+++N + + + N L I + E D G Y +NSAG++
Sbjct: 23101 RPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACRE-DVGHYVVKLTNSAGEAIET 23159
Query: 919 ARVTI 923
V +
Sbjct: 23160 LNVIV 23164
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 13/136 (9%)
Query: 697 ITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIE---PLKSMIVRQ 748
++ +++ E + V A N+ G E LP+++K + EPP++ P ++ VR
Sbjct: 27361 VSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIK---EQLEPPEIDMKNFPSHTVYVRA 27417
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKA-LPTKSDGDTHSITI-LKPKKVKDEGVYTLK 806
G ++ + + G P P +T ++ P+KA + ++ ++TI LK D G Y +
Sbjct: 27418 GSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEIT 27477
Query: 807 AENSEGIAETSAVITV 822
A NS G + I V
Sbjct: 27478 AANSSGTTKAFINIVV 27493
Score = 44.8 bits (101), Expect = 0.003
Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 9/131 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK---EPPQV---IEPLKSMIVRQGE 750
++N+K + V AVN G+ PI + K E P++ + S+I + GE
Sbjct: 28156 VSNLKPGVNYYFRVSAVNCAGQGE-PIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGE 28214
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAE 808
V + G P PT+TW K+ K + + S +T S ++L +V D G Y L E
Sbjct: 28215 DVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIE 28274
Query: 809 NSEGIAETSAV 819
N G ++S V
Sbjct: 28275 NGVGEPKSSTV 28285
Score = 44.4 bits (100), Expect = 0.005
Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F + L + +G+T EC+V ++ WF+ I S+ +++ D V LVI
Sbjct: 13214 FTKPLEDQTVEEGATAVLECEVSR-ENAKVKWFKNGTEILKSKKYEIVADG-RVRKLVIH 13271
Query: 572 EVFPEDAGTFTCVAKN 587
+ PED T+TC AK+
Sbjct: 13272 DCTPEDIKTYTCDAKD 13287
Score = 44.4 bits (100), Expect = 0.005
Identities = 32/114 (28%), Positives = 48/114 (42%), Gaps = 5/114 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRF--QEITVKEKGTIKLVARVTRNP 860
+ + A N GI E V V E + P L ++ I V G I+++A V+ P
Sbjct: 17420 FRVSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKP 17479
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
P++TW N + TI + +VI N G Y +A N AG+
Sbjct: 17480 PPTVTWNMNERTLPQEATIETT--AISSSMVIKNCQRS-HQGVYSLLAKNEAGE 17530
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/90 (25%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTI 1156
A V + PP +++ L+N V +G T E ++ + V W+++ +I+ S Q+T
Sbjct: 934 APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCT 1186
+L I + +D+G ++C N T
Sbjct: 994 QSGIARLMIREAFAEDSGRFTCSAVNEAGT 1023
Score = 44.0 bits (99), Expect = 0.006
Identities = 25/95 (26%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
++ P F+ + + T G +F C V G P + W + A + PS ++++ D +N
Sbjct: 4474 EAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWKI-SDAENK 4532
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
L + + +D G ++C A N G ELI+
Sbjct: 4533 HILELSNLTIQDRGVYSCKASNKFGADICQAELII 4567
Score = 44.0 bits (99), Expect = 0.006
Identities = 38/133 (28%), Positives = 61/133 (45%), Gaps = 7/133 (5%)
Query: 795 KKVKDEGVYTLK--AENS--EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
K++++ Y L+ A N+ EG + +TV EP E A L ++ I + T+
Sbjct: 15991 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVE-LDVSVKGGIQIMAGKTL 16049
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
++ A VT PVP+ W + + + N G EL+I + + D G Y A+N
Sbjct: 16050 RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNV-GTKSELIIKDALRK-DHGRYVITATN 16107
Query: 911 SAGKSSHGARVTI 923
S G ARV +
Sbjct: 16108 SCGSKFAAARVEV 16120
Score = 44.0 bits (99), Expect = 0.006
Identities = 38/148 (25%), Positives = 62/148 (41%), Gaps = 10/148 (6%)
Query: 779 PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPP---LF 835
PT G ++T LK E + + A NSEG+ E A + +E EPP L
Sbjct: 25982 PTGLQGKQFTVTKLKENT---EYNFRICAINSEGVGEP-ATLPGSVVAQERIEPPEIELD 26037
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV 895
+ + + ++ T++L + P P + W + I++ I LVI NV
Sbjct: 26038 ADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQI--EVTSSFTMLVIDNV 26095
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ DSG Y N++G + V +
Sbjct: 26096 -TRFDSGRYNLTLENNSGSKTAFVNVRV 26122
Score = 43.6 bits (98), Expect = 0.008
Identities = 44/191 (23%), Positives = 80/191 (41%), Gaps = 12/191 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PP+ K + V+EG+++ + ++ +P P + W FK PD V ++ ++
Sbjct: 17043 MPPSIDLKEFME-VEEGTNVNIVAKIKGVPFPTLTW-FKAPPKKPDNKEPVLYDTHVNKL 17100
Query: 692 C----SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
L I ++ G YT+ AVN G AS + L + G PP + P+K V
Sbjct: 17101 VVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV-LGRPGPP--VGPIKFESVS 17157
Query: 748 QGESVI--LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK-DEGVYT 804
+ + + G + T + + + + T PK ++ E V+
Sbjct: 17158 ADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFR 17217
Query: 805 LKAENSEGIAE 815
+ A+N GI E
Sbjct: 17218 IMAQNKYGIGE 17228
Score = 43.6 bits (98), Expect = 0.008
Identities = 42/153 (27%), Positives = 68/153 (44%), Gaps = 14/153 (9%)
Query: 700 VKKFQEGT---YTVVAVNREGEASLPIVLKIKTGEKE--PPQV-IEPLKSMIVRQGESVI 753
VK +EG Y V AVN G+ K T + E PP + ++ + +R GE+
Sbjct: 17705 VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFA 17764
Query: 754 LSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
L+ + G P+P ++W K+ V K+ T ++ +K K+ D G Y + ENS
Sbjct: 17765 LTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKR-SDSGKYCVVVENS 17823
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G + + V + PP+ F E+T
Sbjct: 17824 TGSRKGFCQVNV----VDRPGPPVGPVSFDEVT 17852
Score = 43.2 bits (97), Expect = 0.010
Identities = 105/491 (21%), Positives = 175/491 (35%), Gaps = 42/491 (8%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEI--QFSNHIQLTIDGKKQK 1162
P + + + K +G A F++++ G + WF DG +I +++ + + DG Q
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVV-GRPMPETFWFHDGQQIVNDYTHKVVIKEDGT-QS 1514
Query: 1163 LKIYDCDLDDAGEYSC----EVGNSKCTAILTVE--EPSIN--FTLRLPEFILVPANTDA 1214
L I D+GE++ G S + ILTVE E + F +L + +
Sbjct: 1515 LIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSQLE 1574
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTE--KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
+ D+ W K +I + K + + L I D YT ++
Sbjct: 1575 MKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAIN 1634
Query: 1273 --AKSTTKLKVEV-VEFPP-----KIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
+ TT+ KV V VEF K++ YR K + L + + Q ++W
Sbjct: 1635 KAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQ--EQW-EE 1691
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+ K K KP K SL +++ ++ RL D M V L P
Sbjct: 1692 GDLYDKEKQQKPFFKKKLTSL---RLKRFGPAHFECRLTPI---GDPTMVVEWLHDGKPL 1745
Query: 1385 GKPNILEI--DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
N L + + ++ + + + I D T S I K + S+
Sbjct: 1746 EAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHT---SATLIVKDEKSLVE 1802
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
R + E++ A E + + Q P + + + E
Sbjct: 1803 ESQLPEGRKGLQRIEELERM-AHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFR 1861
Query: 1503 CIFGGVPQPKVTWYRDG---KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
C G PQPKV WY +G +K K + Y+ K A N G +
Sbjct: 1862 CRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVI 1921
Query: 1560 ETSCVVGIQQK 1570
E + IQQ+
Sbjct: 1922 EHKVKLEIQQR 1932
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/134 (29%), Positives = 66/134 (49%), Gaps = 12/134 (8%)
Query: 475 MDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSM----AP-IFVE-KLRPKHTPD-GSTV 527
++E + Y K LN + P +PT E Q++ AP IF++ KL T G+ +
Sbjct: 14578 LEEGKWYAYRVKALNRQGASKP--SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKI 14635
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATLVIREVFPEDAGTFTCVAK 586
+ V G P P+ITW + I+K QD ++ ++ +T+ I + D GT+ A
Sbjct: 14636 ELPATVTGKPEPKITWTKADMILK--QDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAV 14693
Query: 587 NAAGFASSTTELIV 600
N G A++ E+ V
Sbjct: 14694 NVCGRATAVVEVNV 14707
Score = 43.2 bits (97), Expect = 0.010
Identities = 30/119 (25%), Positives = 58/119 (48%), Gaps = 7/119 (5%)
Query: 709 TVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL--KSMIVRQGESVILSA-QVVGNPRPT 765
T A++ E++ I+ K + + P V++P + ++ G++++L+A ++G P P
Sbjct: 21280 TAGAISAPSESTETIICKDEY--EAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPK 21337
Query: 766 ITWCKNNKPVKA--LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+W K K ++ + + T S+ +K KD G YT+ A N G +TV
Sbjct: 21338 SSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTV 21396
Score = 43.2 bits (97), Expect = 0.010
Identities = 32/106 (30%), Positives = 55/106 (51%), Gaps = 8/106 (7%)
Query: 712 AVNREGEASLPIVLKIKTGEKEPPQV-IEPL--KSMIVRQGESVILSAQVVGNPRPTITW 768
A+++ +++ PI K E E P++ ++P +++V GE+ L A V G P PTI W
Sbjct: 24530 AISKPSDSTGPITAK---DEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEW 24586
Query: 769 CKNNKPVK--ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ +K ++ A + D ++ I+K D G Y L+A N G
Sbjct: 24587 LRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAG 24632
Score = 42.7 bits (96), Expect = 0.014
Identities = 31/129 (24%), Positives = 61/129 (47%), Gaps = 12/129 (9%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPV 861
+ +KA N+ G+++ SA + + + P + + F E+ E+GT + +VA++ P
Sbjct: 17016 FRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEV---EEGTNVNIVAKIKGVPF 17072
Query: 862 PSITWYR-------NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
P++TW++ N E + + + + LVI D+G Y A N+ G
Sbjct: 17073 PTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQ-SRRSDTGLYTITAVNNLGT 17131
Query: 915 SSHGARVTI 923
+S R+ +
Sbjct: 17132 ASKEMRLNV 17140
Score = 42.7 bits (96), Expect = 0.014
Identities = 25/120 (20%), Positives = 57/120 (47%), Gaps = 4/120 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE-PPQV---IEPLKSMIVRQGESV 752
+ +++ ++ + + A+N G ++ ++ E+E P E ++++VR G S+
Sbjct: 21662 VPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSI 21721
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ + G P P +TW K+N +K + ++ ++ I+ D G + + EN G
Sbjct: 21722 RIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAG 21781
Score = 42.7 bits (96), Expect = 0.014
Identities = 25/75 (33%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTKSDGDTHSITILKPKKVKDE 800
++I++ GE+ L A V G P PT+ W K+ K ++ A D + + K +D
Sbjct: 22397 TVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDS 22456
Query: 801 GVYTLKAENSEGIAE 815
G YTL A N G A+
Sbjct: 22457 GAYTLTATNPGGFAK 22471
Score = 42.7 bits (96), Expect = 0.014
Identities = 37/154 (24%), Positives = 68/154 (44%), Gaps = 10/154 (6%)
Query: 695 LKITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+++ + + E + + A+N+ G + PI+++ K + +E K + +R G
Sbjct: 23825 IEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAG 23884
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ L + G P P + W K + ++ + + +L D G YTL EN
Sbjct: 23885 GSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLEN 23944
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
S G SA +TV + PP+ + + EIT
Sbjct: 23945 SSG--TKSAFVTVR--VLDTPSPPVNL-KVTEIT 23973
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/135 (24%), Positives = 60/135 (44%), Gaps = 7/135 (5%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---PPQVIEPLKSMIVRQGESVI 753
I+ + +E + V AVN +G + P L + ++ P V P + V+ E +
Sbjct: 26282 ISGLTAGEEYVFRVAAVNEKGRSD-PRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLK 26340
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAENSE 811
+ G P+ T+ W K+ + +K + + ++T L K+ +D G Y L NS
Sbjct: 26341 IDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSA 26400
Query: 812 G-IAETSAVITVEEP 825
G I +I ++ P
Sbjct: 26401 GSITVPITIIVLDRP 26415
Score = 42.7 bits (96), Expect = 0.014
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G +++ + V+G P P++TWF+ I+ + ++ D +L +R+ + G +T
Sbjct: 28900 GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEI-TDVLGSTSLFVRDATRDHRGVYTV 28958
Query: 584 VAKNAAGFASSTTELIVE 601
AKNA+G A + ++ V+
Sbjct: 28959 EAKNASGSAKAEIKVKVQ 28976
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISD 1247
+T + P+ FT L +++ +T + +V+W++ VI T IS
Sbjct: 1 MTTQAPT--FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF 58
Query: 1248 VKKRT-LIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
R L I T+ + Y+ + A ST +L V+ PP V + +++G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
S V L V P P ++ + I+ + S + SL I + D+G Y +
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
N+ G A + + + P K + ++ I+
Sbjct: 179 TNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQIS 214
Score = 41.9 bits (94), Expect = 0.024
Identities = 26/100 (26%), Positives = 40/100 (40%), Gaps = 4/100 (4%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PPT K V EG + LEC + P P + W + +I + + +S +
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGI---- 997
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
+ L I G +T AVN G S L ++ E+
Sbjct: 998 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEE 1037
Score = 41.9 bits (94), Expect = 0.024
Identities = 39/131 (29%), Positives = 56/131 (42%), Gaps = 8/131 (6%)
Query: 700 VKKFQEGT---YTVVAVNREGEASLPIVLKIKTGEKEPPQVIE---PLKSMI-VRQGESV 752
VK+ +EG V AVN GE + E + P +E +K I + G+++
Sbjct: 15990 VKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTL 16049
Query: 753 ILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ A V G P PT W K + K + T S I+K KD G Y + A NS
Sbjct: 16050 RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSC 16109
Query: 812 GIAETSAVITV 822
G +A + V
Sbjct: 16110 GSKFAAARVEV 16120
Score = 41.9 bits (94), Expect = 0.024
Identities = 39/133 (29%), Positives = 59/133 (44%), Gaps = 7/133 (5%)
Query: 696 KITNVKKFQEGTYTVVAVNREG--EA-SLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGE 750
+I+ + + QE V A+N+ G EA S+P +K + + P + E K ++VR G
Sbjct: 24908 EISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAGG 24967
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
S + G P P ITW + G ++ + D G Y LK ENS
Sbjct: 24968 SARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS 25027
Query: 811 EGIAETSAVITVE 823
G SA +TV+
Sbjct: 25028 SG--SKSAFVTVK 25038
Score = 41.5 bits (93), Expect = 0.032
Identities = 39/159 (24%), Positives = 63/159 (39%), Gaps = 11/159 (6%)
Query: 450 TSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEK-IDKLPVFEKPTSEEQSM 508
T + W K EE + + L++ Y ++ K +N + K P ++
Sbjct: 16985 TKKEAWRQCNKRDVEELQFT-VEDLVEGGEY-EFRVKAVNAAGVSKPSATVGPCDCQRPD 17042
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD------ 562
P ++ +G+ V +++G P P +TWF+ KP + YD
Sbjct: 17043 MPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPP-KKPDNKEPVLYDTHVNKLV 17101
Query: 563 -DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
D+ TLVI + D G +T A N G AS L V
Sbjct: 17102 VDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 17140
Score = 41.5 bits (93), Expect = 0.032
Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--D 799
K++I+R G ++ L V G P P ITW K N ++ T T L+ + V D
Sbjct: 20628 KTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYD 20687
Query: 800 EGVYTLKAENSEGIAETSAVITV 822
G Y L ENS G E + V+ V
Sbjct: 20688 AGKYILTLENSCGKKEYTIVVKV 20710
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/75 (29%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ ++AEN+ GI+E S + + P + + E VK I L A ++ +P P
Sbjct: 15579 FRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLE--VKRGDEIALDASISGSPYP 15636
Query: 863 SITWYRNNEIISPSE 877
+ITW ++ +I P E
Sbjct: 15637 TITWIKDENVIVPEE 15651
Score = 41.1 bits (92), Expect = 0.042
Identities = 33/131 (25%), Positives = 57/131 (43%), Gaps = 5/131 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEK--EPPQVIEP--LKSMIVRQGES 751
+T+++ +E + V A+N G+ S + IK ++ P I+ ++ +VR G S
Sbjct: 29242 VTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGAS 29301
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L G P PT W K + + D+ S ++ D G YTL EN+
Sbjct: 29302 IRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNS 29361
Query: 812 GIAETSAVITV 822
G + + V
Sbjct: 29362 GSKSITFTVKV 29372
Score = 40.7 bits (91), Expect = 0.056
Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 4/91 (4%)
Query: 1575 ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKE 1634
+SN DI +GD ++ + GIP P++ W+ NG L +Y + I
Sbjct: 3509 VSNADIS----MGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILF 3564
Query: 1635 LKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
K +YT ASN G + LK+ K
Sbjct: 3565 TKLEDEGEYTCMASNDYGKTICSAYLKINSK 3595
Score = 40.7 bits (91), Expect = 0.056
Identities = 21/81 (25%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+F +K P GS V +C++ G P ++ W + ++ S+ F++ + +L
Sbjct: 7385 PVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFD-TSLH 7443
Query: 570 IREVFPEDAGTFTCVAKNAAG 590
I + D G + C A N G
Sbjct: 7444 ILNLEASDVGEYHCKATNEVG 7464
Score = 40.7 bits (91), Expect = 0.056
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T++ +V+G P P ITW ++ ++ + + D V L I+E D G +
Sbjct: 18850 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRV-ELQIKEAVRADHGKYII 18908
Query: 584 VAKNAAGFASST 595
AKN++G A +
Sbjct: 18909 SAKNSSGHAQGS 18920
Score = 40.7 bits (91), Expect = 0.056
Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 3/78 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV-IREVFPEDAGTFT 582
G ++ E V G PRP I+W + +K Q ++ ++ +T++ I+E +D G +T
Sbjct: 25253 GEDLKIEIPVIGRPRPNISWVKDGEPLK--QTTRVNVEETATSTVLHIKEGNKDDFGKYT 25310
Query: 583 CVAKNAAGFASSTTELIV 600
A N+AG A+ +IV
Sbjct: 25311 VTATNSAGTATENLSVIV 25328
Score = 40.7 bits (91), Expect = 0.056
Identities = 33/125 (26%), Positives = 57/125 (45%), Gaps = 9/125 (7%)
Query: 705 EGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQ 757
E + V +VN+ G ++S P + K + E+EP I E K++IV+ G S ++
Sbjct: 27079 EYVFRVKSVNKVGASDPSDSSDPQIAKER--EEEPLFDIDSEMRKTLIVKAGASFTMTVP 27136
Query: 758 VVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETS 817
G P P + W K + ++ D+ + ++ D G YTL +N A +
Sbjct: 27137 FRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLT 27196
Query: 818 AVITV 822
V+ V
Sbjct: 27197 LVVKV 27201
Score = 40.7 bits (91), Expect = 0.056
Identities = 40/142 (28%), Positives = 66/142 (46%), Gaps = 11/142 (7%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASL----PIVLK--IKTGEKEPPQVIEPLKSMIVRQ 748
++++ +K+ + V A N +G + PI +K I T E + + P + VR
Sbjct: 28447 IEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDI--PGAQVTVRI 28504
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDE--GVYTLK 806
G +V L G P+P+I+W K+ P+K T + L K K E G YT+
Sbjct: 28505 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 28564
Query: 807 AENSE-GIAETSAVITVEEPTE 827
+N+ IA VIT+ P++
Sbjct: 28565 LDNAVCRIAVPITVITLGPPSK 28586
Score = 40.3 bits (90), Expect = 0.074
Identities = 31/127 (24%), Positives = 58/127 (45%), Gaps = 6/127 (4%)
Query: 802 VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-TVKEKGTIKLVARVTRNP 860
+Y + + E+ V T E +E+ + P+ + + TVK TI+L A V P
Sbjct: 19097 IYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKP 19156
Query: 861 VPSITWYRNNEI--ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P + W ++ + ++ S + + ++ + +T D G Y A+N+AG S
Sbjct: 19157 FPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKA-KRSDGGKYVVTATNTAG--SFV 19213
Query: 919 ARVTIDV 925
A T++V
Sbjct: 19214 AYATVNV 19220
Score = 40.3 bits (90), Expect = 0.074
Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ E + G P+P ITW + +K + + D ++ TL I+E +D G +
Sbjct: 24171 GQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINV-TDSLDLTTLSIKETHKDDGGQYGI 24229
Query: 584 VAKNAAGFASSTTELI 599
N G +++ E++
Sbjct: 24230 TVANVVGQKTASIEIV 24245
Score = 39.9 bits (89), Expect = 0.098
Identities = 28/106 (26%), Positives = 46/106 (43%), Gaps = 6/106 (5%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
I P+ + G D+ +E ++ P P+I+W+ GE + ++V +
Sbjct: 25237 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNV----EETAT 25292
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA--SLPIVLKIKTGEKEPP 735
+VL I K G YTV A N G A +L +++ K G P
Sbjct: 25293 STVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGP 25338
Score = 39.9 bits (89), Expect = 0.098
Identities = 28/79 (35%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTKSDGDTHSITILKPKKVKDEGVYT 804
R G SV L A + G P PTI W K++K ++ AL + + ++K + G Y
Sbjct: 27812 RAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYE 27871
Query: 805 LKAENSEGIAETSAVITVE 823
LK N+ G A SA I V+
Sbjct: 27872 LKLRNAMGSA--SATIRVQ 27888
Score = 39.5 bits (88), Expect = 0.13
Identities = 53/244 (21%), Positives = 91/244 (37%), Gaps = 20/244 (8%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXXXXXX 1538
P E+ L+++T + + +TC F VP K W+R+G+ LK K E++
Sbjct: 9672 PAWERHLQDVTLKEGQTCTMTCQFS-VPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTI 9730
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE- 1597
+ D +ETS + I+ +P+ Q V + T E
Sbjct: 9731 ADVRAEDQGQYTCKYED---LETSAELRIEAEPIQFTKRI---QNIVVSEHQSATFECEV 9784
Query: 1598 GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI--------EASN 1649
V WYK +L ++YN + + I + Y++ EA +
Sbjct: 9785 SFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARS 9844
Query: 1650 TAGTSSVEVTLKVYDKPSK-PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
TA +K+ KP P+ V + + +V E PP+ + L E+ +P
Sbjct: 9845 TAELYLTTKEIKLELKPPDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTPEEKKP 9904
Query: 1709 DNNR 1712
R
Sbjct: 9905 PPKR 9908
Score = 39.5 bits (88), Expect = 0.13
Identities = 33/134 (24%), Positives = 65/134 (48%), Gaps = 14/134 (10%)
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV----- 1658
V+W+KN KL + I+++ KT + +KE+ S+ + + T+ ++V
Sbjct: 12531 VVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADP 12590
Query: 1659 --TLKVYDKPSKPEGPVIMR-EISRESVTIEWKPPLDDGG--LELTKYAIEKHEPDNNRW 1713
T+K++DK + + + ++ E+S++ V ++W DG + KY+I+
Sbjct: 12591 YFTVKLHDKTAVEKDEITLKCEVSKD-VPVKW---FKDGEEIVPSPKYSIKADGLRRILK 12646
Query: 1714 IKVADVDRDVETYC 1727
IK AD+ E C
Sbjct: 12647 IKKADLKDKGEYVC 12660
Score = 39.5 bits (88), Expect = 0.13
Identities = 26/100 (26%), Positives = 46/100 (46%), Gaps = 4/100 (4%)
Query: 504 EEQSMAPIFVEKLRPKHTP---DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
+EQ P K P HT GS ++ + + G P P++T R +K + F
Sbjct: 27395 KEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEI 27454
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+N+ T+ ++E DAG + A N++G + ++V
Sbjct: 27455 TAENL-TINLKESVTADAGRYEITAANSSGTTKAFINIVV 27493
Score = 39.5 bits (88), Expect = 0.13
Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G V E +G P+P I+W + +K S +F + +N TL I+ E G +T
Sbjct: 28505 GHNVHLELPYKGKPKPSISWLKDGLPLKES-EFVRFSKTENKITLSIKNAKKEHGGKYTV 28563
Query: 584 VAKNA 588
+ NA
Sbjct: 28564 ILDNA 28568
Score = 39.1 bits (87), Expect = 0.17
Identities = 34/142 (23%), Positives = 63/142 (44%), Gaps = 9/142 (6%)
Query: 808 ENSEGIAETSAVITVEEPTEENAEP-----PLFINRFQEITVKEKGTIKLVARVTRNPVP 862
E + V+T TEE A P P FI + + E G++ +V NP P
Sbjct: 1052 EEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKP 1111
Query: 863 SITWYRNNEIISPS--ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ W ++ ++ ++ N +LVI+ ++ D+G+Y V N G++S A
Sbjct: 1112 HVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFAD-DAGEYTIVVRNKHGETSASAS 1170
Query: 921 VTIDVEKVTFVKHLQKS-YETE 941
+ + + +K Q+ Y+T+
Sbjct: 1171 LLEEADYELLMKSQQEMLYQTQ 1192
Score = 39.1 bits (87), Expect = 0.17
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNIT-TKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P++ WYK+G ++++ + Y + ++ + +RI + YT ASN G +
Sbjct: 1314 MSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNA 1373
Query: 1655 SVEVTLKVYDKPSKPEG 1671
+ K+Y +P+ P G
Sbjct: 1374 I--CSGKLYVEPAAPLG 1388
Score = 39.1 bits (87), Expect = 0.17
Identities = 39/123 (31%), Positives = 55/123 (44%), Gaps = 8/123 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLK--IKTGE-KEPPQV---IEPLKSMIVRQGE 750
+T++ + QE + V A N+ G P LK IK E EPP++ K +IVR G
Sbjct: 19491 VTSLDENQEYEFRVCAQNQVG-IGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGC 19549
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSD-GDTHSITILKPKKVKDEGVYTLKAEN 809
+ L A V G P P +TW K + D DT + ++ D G Y+L N
Sbjct: 19550 PIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVN 19609
Query: 810 SEG 812
G
Sbjct: 19610 PAG 19612
Score = 39.1 bits (87), Expect = 0.17
Identities = 22/86 (25%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 839 FQEITVKEKGT-IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDS 897
+ E+ GT +KL A ++ P P+I WY++++ + + + + ++I + D
Sbjct: 27805 YTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDAD- 27863
Query: 898 EIDSGDYKCVASNSAGKSSHGARVTI 923
++SG Y+ N+ G +S RV I
Sbjct: 27864 RLNSGCYELKLRNAMGSASATIRVQI 27889
Score = 38.7 bits (86), Expect = 0.23
Identities = 29/129 (22%), Positives = 54/129 (41%), Gaps = 4/129 (3%)
Query: 796 KVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEP-PLFINRFQEITVKEKGTIKLVA 854
+ K++ + + A N G+ E + + VE E A L + + V+ +I++
Sbjct: 21666 QTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFV 21725
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+ P P +TW ++N + I E+ L+I + D+G + N AGK
Sbjct: 21726 PIKGRPAPEVTWTKDNINLKNRANIENT---ESFTLLIIPECNRYDTGKFVMTIENPAGK 21782
Query: 915 SSHGARVTI 923
S V +
Sbjct: 21783 KSGFVNVRV 21791
Score = 38.7 bits (86), Expect = 0.23
Identities = 56/251 (22%), Positives = 103/251 (41%), Gaps = 28/251 (11%)
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
T K + TY V ++ E ++ + + G EP + EP+K+ L+
Sbjct: 21843 TATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDS-LNIM 21901
Query: 758 VVGNPRPTITWCKNNKP---------VKALPTKSDGDTHSITI------LKPKKVKDEGV 802
+ ++ W K ++A SD TH T+ ++ +E
Sbjct: 21902 DITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYT 21961
Query: 803 YTLKAENSEGIA--ETSAVITVEEPTEENAEPPLFINR-FQEITVKEKG-TIKLVARVTR 858
+ + A NS G + S + V+E T P L + +Q++ + + G IK+ V
Sbjct: 21962 FQVMAVNSAGRSAPRESRPVIVKEQT---MLPELDLRGIYQKLVIAKAGDNIKVEIPVLG 22018
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVIT-NVDSEIDSGDYKCVASNSAGKSSH 917
P P++TW + ++I+ ++ + NF+ ++ N DSG Y A N G+
Sbjct: 22019 RPKPTVTWKKGDQILKQTQRV--NFETTATSTILNINECVRSDSGPYPLTARNIVGEV-- 22074
Query: 918 GARVTIDVEKV 928
G +TI V +
Sbjct: 22075 GDVITIQVHDI 22085
Score = 38.7 bits (86), Expect = 0.23
Identities = 31/120 (25%), Positives = 52/120 (43%), Gaps = 7/120 (5%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPP---LFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A NSEG+ E A++ E+ PP L + + +T++ T++L + P P
Sbjct: 22760 AMNSEGLGEP-ALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPE 22818
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ W R++ +I L++ NV + DSG Y NS+G S V +
Sbjct: 22819 VKWARDHGESLDKASIEST--SSYTLLIVGNV-NRFDSGKYILTVENSSGSKSAFVNVRV 22875
Score = 38.7 bits (86), Expect = 0.23
Identities = 35/145 (24%), Positives = 58/145 (40%), Gaps = 8/145 (5%)
Query: 784 GDTHSITILKPKKV-KDEGVYTLKAENSEGIAET----SAVITVEEPTEENAEPPLFINR 838
G T +T + V K E + +KA+N G +E S+VI E E A+ N
Sbjct: 29523 GHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITN- 29581
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSE 898
Q IT K + ++ P P +TW + ++ ++ + L + +
Sbjct: 29582 -QLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKD-SMR 29639
Query: 899 IDSGDYKCVASNSAGKSSHGARVTI 923
DSG Y N+AG + V +
Sbjct: 29640 GDSGRYFLTLENTAGVKTFSVTVVV 29664
Score = 38.3 bits (85), Expect = 0.30
Identities = 39/181 (21%), Positives = 75/181 (41%), Gaps = 12/181 (6%)
Query: 1507 GVPQPKVTWYRDGKKL---KTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G P P+ W+ DG+++ T K + + +A N G
Sbjct: 1482 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1541
Query: 1562 SCVVGIQ--QKPVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK- 1617
S ++ ++ + V + E +K + K G + + G P P+++W KN + + K
Sbjct: 1542 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPNPDIVWLKNSDIIVPHKY 1601
Query: 1618 -EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLKVYDKPSKPEGPVI 1674
+ I + + ++I S+ YT A N AG T+ +V ++V +PE +I
Sbjct: 1602 PKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLI 1661
Query: 1675 M 1675
+
Sbjct: 1662 I 1662
Score = 38.3 bits (85), Expect = 0.30
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 9/97 (9%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK--NNKPVKALPTKSDGDTHSI--- 789
P I+ + M V +G +V + A++ G P PT+TW K KP P D + +
Sbjct: 17044 PPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD 17103
Query: 790 ---TILKPK-KVKDEGVYTLKAENSEGIAETSAVITV 822
T++ P+ + D G+YT+ A N+ G A + V
Sbjct: 17104 DTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 17140
Score = 38.3 bits (85), Expect = 0.30
Identities = 49/181 (27%), Positives = 78/181 (43%), Gaps = 13/181 (7%)
Query: 640 PKAQY-VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKIT 698
P AQ V G ++ LE P+P I+WL G + E + + + L I
Sbjct: 28496 PGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENK----ITLSIK 28551
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQV 758
N KK G YTV+ N ++PI + I G P+ P++ ++ +SVILS V
Sbjct: 28552 NAKKEHGGKYTVILDNAVCRIAVPITV-ITLGPPSKPK--GPIRFDEIK-ADSVILSWDV 28607
Query: 759 VGNPRPTITWCKNNKPVKALPTKSDGDTHSI---TILKPKKVKD-EGVYTLKAENSEGIA 814
+ C + + + T S+ T P VKD E + ++AEN G++
Sbjct: 28608 PEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVS 28667
Query: 815 E 815
+
Sbjct: 28668 Q 28668
Score = 37.9 bits (84), Expect = 0.39
Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV+F + G P P W + IK + + + D+ + + L I+ D G +
Sbjct: 18452 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFS-SVLTIKNCLRRDTGEYQI 18510
Query: 584 VAKNAAGFASSTTELIV 600
NAAG + L V
Sbjct: 18511 TVSNAAGSKTVAVHLTV 18527
Score = 37.9 bits (84), Expect = 0.39
Identities = 32/156 (20%), Positives = 69/156 (44%), Gaps = 10/156 (6%)
Query: 673 EIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
+ + +EN + + + S +T K++ T+ V A N GE + + + +
Sbjct: 20848 DFLTEENKWQRVMKSLSLQYSAKDLTEGKEY---TFRVSAENENGEGTPSEITVVARDDV 20904
Query: 733 EPPQV-IEPLKSM--IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI 789
P + ++ L + + ++ + L + G P P+++W K P+ A T+ ++ ++
Sbjct: 20905 VAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPL-ATDTRVSVESSAV 20963
Query: 790 T---ILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
I+ + D G YT+ +N G E + I V
Sbjct: 20964 NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 20999
Score = 37.9 bits (84), Expect = 0.39
Identities = 24/116 (20%), Positives = 46/116 (39%), Gaps = 5/116 (4%)
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEIT--VKEKGTIKLVARVT 857
E + + AEN G S + V ++ P L + ++ KE +L +
Sbjct: 20877 EYTFRVSAENENGEGTPSEITVVAR--DDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIK 20934
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P PS++W + + ++ ++ N L++ + D+G Y N AG
Sbjct: 20935 GKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKS-DAGKYTITLKNVAG 20989
Score = 37.9 bits (84), Expect = 0.39
Identities = 37/131 (28%), Positives = 59/131 (45%), Gaps = 9/131 (6%)
Query: 798 KDEGVYTLKAENSEGIAETSAV---ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
K E + + A N G+ E + V I VEE E + L + + I ++ G+++L
Sbjct: 23833 KHEYNFRICAINKAGVGEHADVPGPIIVEEKLEA-PDIDLDLELRKIINIRAGGSLRLFV 23891
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+ P P + W + + I + I + LV+ NV + DSG Y NS+G
Sbjct: 23892 PIKGRPTPEVKWGKVDGEIRDAAII--DVTSSFTSLVLDNV-NRYDSGKYTLTLENSSGT 23948
Query: 915 SSHGARVTIDV 925
S A VT+ V
Sbjct: 23949 KS--AFVTVRV 23957
Score = 37.5 bits (83), Expect = 0.52
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 9/109 (8%)
Query: 509 APIFVEKLRPKHT------PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
A +FVE L T P+ T FEC+V + P + W + I+ S+ F++
Sbjct: 2875 AKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVV-Q 2932
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASST-TELIVEAPLSDHGSE 610
+ L+I ED+ +T V N A+ T T +++ + L D +E
Sbjct: 2933 GKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLKDINAE 2981
Score = 37.5 bits (83), Expect = 0.52
Identities = 20/81 (24%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ E V G P P W + + S ++ D + + L+I++V +D+G ++
Sbjct: 19840 GKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSS-SILIIKDVTRKDSGYYSL 19898
Query: 584 VAKNAAGFASSTTELIV-EAP 603
A+N++G + +++V +AP
Sbjct: 19899 TAENSSGTDTQKIKVVVMDAP 19919
Score = 37.5 bits (83), Expect = 0.52
Identities = 29/125 (23%), Positives = 54/125 (43%), Gaps = 5/125 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFI---NRFQEITVKEKGTIKLVA-RVTR 858
+ ++A+N+ G + T ++ E P + +T+K TI L A +
Sbjct: 21273 FRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILG 21332
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P+P +W + + I PS+ ITQ ++ + D+G+Y A+N G
Sbjct: 21333 KPLPKSSWSKAGKDIRPSD-ITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH 21391
Query: 919 ARVTI 923
+VT+
Sbjct: 21392 VKVTV 21396
Score = 37.5 bits (83), Expect = 0.52
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 3/68 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV-IREVFPEDAGTFT 582
G ++ E V G P+P +TW + I+K +Q ++ ++ +T++ I E D+G +
Sbjct: 22007 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQ--RVNFETTATSTILNINECVRSDSGPYP 22064
Query: 583 CVAKNAAG 590
A+N G
Sbjct: 22065 LTARNIVG 22072
Score = 37.5 bits (83), Expect = 0.52
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 4/88 (4%)
Query: 838 RFQEITVKEKG-TIKLVARVTRNPVPSITWYR-NNEIISPSETITQNFDGENIELVITNV 895
+F++ V G T +L A V P+P+I W R + EI + +N D + L+I
Sbjct: 24557 KFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFK--ALLIVKD 24614
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTI 923
ID G Y ASN AG S V +
Sbjct: 24615 AIRIDGGQYILRASNVAGSKSFPVNVKV 24642
Score = 37.5 bits (83), Expect = 0.52
Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T + E V G P P I W R I+ S ++ + D A L++++ D G +
Sbjct: 24567 GETFRLEADVHGKPLPTIEWLRGDKEIEESARCEI-KNTDFKALLIVKDAIRIDGGQYIL 24625
Query: 584 VAKNAAGFAS 593
A N AG S
Sbjct: 24626 RASNVAGSKS 24635
Score = 37.5 bits (83), Expect = 0.52
Identities = 36/141 (25%), Positives = 62/141 (43%), Gaps = 9/141 (6%)
Query: 789 ITILKPKKVKDEGVYTLK--AENSEGIAETSAVITVEEPTEENAEPPLFINRF--QEITV 844
+T + K+ + Y ++ A N G+ E ++V +P ++ P L ++ + I V
Sbjct: 24904 VTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVV 24963
Query: 845 KEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDY 904
+ G+ ++ P P ITW R + I + + +L I N D D+G Y
Sbjct: 24964 RAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVN--YTQLSIDNCDRN-DAGKY 25020
Query: 905 KCVASNSAGKSSHGARVTIDV 925
NS+G S A VT+ V
Sbjct: 25021 ILKLENSSGSKS--AFVTVKV 25039
Score = 37.5 bits (83), Expect = 0.52
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 13/125 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREG---EASLPIVLKIKTGEKEPPQV---IEPLKSMIVRQGE 750
+T +K+ E + + A+N EG A+LP + + EPP++ + K +++R
Sbjct: 25992 VTKLKENTEYNFRICAINSEGVGEPATLPGSV-VAQERIEPPEIELDADLRKVVVLRASA 26050
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGD-THSITILKPKKVK--DEGVYTLKA 807
++ L + G P P + W K L ++ + T S T+L V D G Y L
Sbjct: 26051 TLRLFVTIKGRPEPEVKW---EKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTL 26107
Query: 808 ENSEG 812
EN+ G
Sbjct: 26108 ENNSG 26112
Score = 37.1 bits (82), Expect = 0.69
Identities = 15/50 (30%), Positives = 24/50 (48%)
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
I E++ + +KN + C G P PK+ WY+DGK++K
Sbjct: 1283 ISESEAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK 1332
Score = 37.1 bits (82), Expect = 0.69
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 5/72 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFR-QTAIIKPSQDFQMYYDD----DNVATLVIREVFPEDA 578
G V V G P P+I W + +T I KP+ Q+ ++ + L I + ED
Sbjct: 16340 GEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDK 16399
Query: 579 GTFTCVAKNAAG 590
GT+T A N G
Sbjct: 16400 GTYTVTASNRLG 16411
Score = 36.7 bits (81), Expect = 0.91
Identities = 56/273 (20%), Positives = 103/273 (37%), Gaps = 14/273 (5%)
Query: 150 RVTLEKSDLFDSQEDESKPDVSQP--PQNIIEEAKSEPKLIEESEQPIAKTSEIDNEV-- 205
++T E+ L + E+ P P P+ + E K + E+P AK +E V
Sbjct: 10569 QITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVK 10628
Query: 206 PEKINVPDDKETSQTPTSFN-KRSKLTPIKIERKEMEVSTPQHAETVDGPQFXXXXXXXX 264
EK+++ K Q K +E + + V + E + +
Sbjct: 10629 EEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEP 10688
Query: 265 XXXXXXETSLVKLPKFQLKSRIKYITS-WPPESIKPLISYMGSIKQNGILSRNIKEAAKV 323
+ + + +YIT P +KP+ K ++ +K+A
Sbjct: 10689 TEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPE 10748
Query: 324 KK-QVFVPPKLPDVEKTELEQPLFSYEDIVE---SKKDENEIIQEKQTLEELPKEDVPEQ 379
+K V +P KL E+P +E+ + +K+++ ++ + + PK V E+
Sbjct: 10749 EKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEE 10808
Query: 380 YTITPRKSSAQKIDEIVDEVTIKKRLNPFEIFY 412
PRK A + V EV K L P E+ +
Sbjct: 10809 KVPVPRKEVAPPVR--VPEV--PKELEPEEVAF 10837
Score = 36.7 bits (81), Expect = 0.91
Identities = 23/58 (39%), Positives = 28/58 (48%), Gaps = 4/58 (6%)
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN---SKCTAI-LTV 1191
+W DGSEI+ H + D L I +C D GEY V N SK A+ LTV
Sbjct: 18470 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTV 18527
Score = 36.3 bits (80), Expect = 1.2
Identities = 30/136 (22%), Positives = 60/136 (44%), Gaps = 12/136 (8%)
Query: 937 SYETEEGKTVILECQT--SHTVSTKWYHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXD 993
S++ EG+T + + T W+H+ ++I + H+ +I+E D
Sbjct: 1465 SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSD 1524
Query: 994 VGVIKCIVKDQ----ETSTMLVVK----ETIPEFIRKLQDFEVKEKDVAILEVEINSE-T 1044
G + +++ S +L V+ + P F+ KL++ +KE ++V
Sbjct: 1525 SGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPN 1584
Query: 1045 ADVVWERDGEIIKPKK 1060
D+VW ++ +II P K
Sbjct: 1585 PDIVWLKNSDIIVPHK 1600
Score = 36.3 bits (80), Expect = 1.2
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 174 PQNIIEEAKSEPKLIEESEQPIAKTSEIDNEVPEKINVPDDKETSQTPTSFNKRSKLTPI 233
P + EE + EP EE + E++ P ++ K + PT K+ + P
Sbjct: 11161 PVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPA 11220
Query: 234 KIERKEMEVSTPQHAETVDGP 254
K+ +K E P + + P
Sbjct: 11221 KVSKKIPEEKVPVPVQKKEAP 11241
Score = 36.3 bits (80), Expect = 1.2
Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 8/107 (7%)
Query: 822 VEEPT--EENAEPPLFI---NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
V EP ++ EPP I N +E +K T++L A + P P +TW + +
Sbjct: 18130 VPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTK 18189
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
I G +E I N E D G Y N AG + +V +
Sbjct: 18190 ARIDVTPVGSKLE--IRNAAHE-DGGIYSLTVENPAGSKTVSVKVLV 18233
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G+ + + +P P W G EI DE+ +V E+D + SVL I N +
Sbjct: 18449 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTV--ETD--NFSSVLTIKNCLRRD 18504
Query: 705 EGTYTVVAVNREGEASLPIVLKI 727
G Y + N G ++ + L +
Sbjct: 18505 TGEYQITVSNAAGSKTVAVHLTV 18527
Score = 36.3 bits (80), Expect = 1.2
Identities = 20/77 (25%), Positives = 35/77 (45%), Gaps = 1/77 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ + G P P +TW + +K + ++N + L I++ ED G +
Sbjct: 23089 GEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENN-SLLTIKDACREDVGHYVV 23147
Query: 584 VAKNAAGFASSTTELIV 600
N+AG A T +IV
Sbjct: 23148 KLTNSAGEAIETLNVIV 23164
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/82 (28%), Positives = 35/82 (42%), Gaps = 3/82 (3%)
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD-GDTHSITILKPKKV--KDE 800
++V GE+ +L A + G P P + W K+ K ++ + + T T L K D
Sbjct: 25644 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 25703
Query: 801 GVYTLKAENSEGIAETSAVITV 822
G Y LK N G + V
Sbjct: 25704 GQYILKLSNVGGTKSIPITVKV 25725
Score = 35.9 bits (79), Expect = 1.6
Identities = 50/244 (20%), Positives = 97/244 (39%), Gaps = 20/244 (8%)
Query: 170 VSQPPQNIIEEAKSEPKLIEESEQPIAKTSEIDNEVPEKINVPDDKETSQTPTSFNKRSK 229
V + P+ + E K + ++ E P AK E+ + EK+ V K+ P + K
Sbjct: 10877 VPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPK 10936
Query: 230 LTPIKIERKEMEVSTPQHAETVDGPQFXXXXXXXXXXXXXXETSLVKLPKFQLKSRIKYI 289
P+ E+ + V A P+ V+ P ++ K +
Sbjct: 10937 -KPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKK-VEAPPAKVPEVPKKL 10994
Query: 290 TSWPPESIKPLISYMGSIKQNGILSRNIKEAAKVKKQVFVPPKLPDVEKTELEQPLFSYE 349
PE KP + + + + K ++ V VP LP E+ E+ + E
Sbjct: 10995 I---PEEKKPT-----PVPKK--VEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEE 11044
Query: 350 DIVESKKD----ENEIIQEKQTLEELPKED--VPEQYTITPRKSSAQKIDEIVDEVTIKK 403
+++ +++ E E++ E++ E LP+E+ PE+ + P + + +E V E +
Sbjct: 11045 EVLPEEEEVLPEEEEVLPEEE--EVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLP 11102
Query: 404 RLNP 407
+ P
Sbjct: 11103 EVKP 11106
Score = 35.9 bits (79), Expect = 1.6
Identities = 27/79 (34%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQIT-WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
GS+ FEC V P IT W + + I+ S + D + L I +V DAG +T
Sbjct: 12060 GSSAIFECLVS--PSTAITTWMKDGSNIRESPKHRFIADGKD-RKLHIIDVQLSDAGEYT 12116
Query: 583 CVAKNAAGFASSTTELIVE 601
CV + +ST +L+VE
Sbjct: 12117 CVLRLGNKEKTSTAKLVVE 12135
Score = 35.9 bits (79), Expect = 1.6
Identities = 13/33 (39%), Positives = 22/33 (66%)
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
S+ V++G+ + L A + G+P PTITW K+ +
Sbjct: 15615 SLEVKRGDEIALDASISGSPYPTITWIKDENVI 15647
Score = 35.9 bits (79), Expect = 1.6
Identities = 29/134 (21%), Positives = 55/134 (41%), Gaps = 5/134 (3%)
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIK 851
+K K D Y + A N G + S +E A P L ++ ++T++
Sbjct: 17705 VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFA 17764
Query: 852 LVARVTRNPVPSITWYRNN-EIISPSETITQNFDGENIELVITNVDSE-IDSGDYKCVAS 909
L R + P P ++W+++ +++ T + L + + ++ DSG Y V
Sbjct: 17765 LTGRYSGKPKPKVSWFKDEADVLEDDRT---HIKTTPATLALEKIKAKRSDSGKYCVVVE 17821
Query: 910 NSAGKSSHGARVTI 923
NS G +V +
Sbjct: 17822 NSTGSRKGFCQVNV 17835
Score = 35.9 bits (79), Expect = 1.6
Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 10/86 (11%)
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKN-------NKPVKALPTKSDGDTHSITILKPKK 796
+ V+ G+++ L A V G P P + W K+ P + T++D S+T K K+
Sbjct: 19138 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLT--KAKR 19195
Query: 797 VKDEGVYTLKAENSEGIAETSAVITV 822
D G Y + A N+ G A + V
Sbjct: 19196 -SDGGKYVVTATNTAGSFVAYATVNV 19220
Score = 35.5 bits (78), Expect = 2.1
Identities = 22/98 (22%), Positives = 42/98 (42%), Gaps = 3/98 (3%)
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+QKP I + E ++ G+ + G P P+V WY NG + K + + +
Sbjct: 1838 KQKPDIVLYPEPVRVLE--GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV-RYDGI 1894
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
+ I + K + + + A N G +V L++ +
Sbjct: 1895 HYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQR 1932
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/103 (24%), Positives = 46/103 (44%), Gaps = 7/103 (6%)
Query: 505 EQSMAPIF---VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
E+ MAP F E R G +++ ++G P P++TW + +K + + +
Sbjct: 21696 EREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIE---N 21752
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
++ L+I E D G F +N AG S + +++ P
Sbjct: 21753 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTP 21795
Score = 35.1 bits (77), Expect = 2.8
Identities = 20/63 (31%), Positives = 34/63 (53%), Gaps = 3/63 (4%)
Query: 149 ERVTLEK--SDLFDSQEDESKPDVSQPPQNIIEEAKSEPKLIEESEQPIAKTSEIDNE-V 205
E V LE+ +++ + E + P V+ PP+ + E K+ + ++ E P K E+ E V
Sbjct: 11597 EEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVV 11656
Query: 206 PEK 208
PEK
Sbjct: 11657 PEK 11659
Score = 35.1 bits (77), Expect = 2.8
Identities = 37/161 (22%), Positives = 67/161 (41%), Gaps = 12/161 (7%)
Query: 446 YILD--TSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDKLPVFEKPTS 503
Y++D T W V K L+ + A+ L + YT + + NE + P +
Sbjct: 20845 YVVDFLTEENKWQRVMKSLSLQYS---AKDLTEGKEYTFRVSAE-NENGEGTPSEITVVA 20900
Query: 504 EEQSMAPIFVEKLRPKH---TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
+ +AP K P + S + + ++G P P ++W + + + D ++
Sbjct: 20901 RDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPL--ATDTRVSV 20958
Query: 561 DDDNV-ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ V TL++ + DAG +T KN AG T + V
Sbjct: 20959 ESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 20999
Score = 35.1 bits (77), Expect = 2.8
Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 8/107 (7%)
Query: 634 PTFSKKPKAQ---YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
P S PK + V G +LE + P PD+ W G+E+ E + +E +
Sbjct: 25632 PNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKEL---EETAARMEIKSTI 25688
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI--KTGEKEPP 735
+ L + + + G Y + N G S+PI +K+ + G E P
Sbjct: 25689 QKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGP 25735
Score = 35.1 bits (77), Expect = 2.8
Identities = 19/81 (23%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS + + G P P++TW + +K + + D TL +++ D+G +
Sbjct: 29589 GSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDR-TTLTVKDSMRGDSGRYFL 29647
Query: 584 VAKNAAGFAS-STTELIVEAP 603
+N AG + S T +++ P
Sbjct: 29648 TLENTAGVKTFSVTVVVIGRP 29668
Score = 34.7 bits (76), Expect = 3.7
Identities = 25/121 (20%), Positives = 53/121 (43%), Gaps = 2/121 (1%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ +KA N +G ++ + + +P L + F +++ +K+ V P P
Sbjct: 25210 FRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLP-FNTYSIQAGEDLKIEIPVIGRPRP 25268
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+I+W ++ E + + + + L I + + D G Y A+NSAG ++ V
Sbjct: 25269 NISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKD-DFGKYTVTATNSAGTATENLSVI 25327
Query: 923 I 923
+
Sbjct: 25328 V 25328
Score = 34.3 bits (75), Expect = 4.9
Identities = 22/94 (23%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
PT + V EG + + A+P P ++W G+E+ + ++ +++D H+ +
Sbjct: 15314 PTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLT--MKND-HI-SA 15369
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L++ + G YT+ N+ G A+ I +K+
Sbjct: 15370 HLEVPKSVRADAGIYTITLENKLGSATASINVKV 15403
Score = 34.3 bits (75), Expect = 4.9
Identities = 37/130 (28%), Positives = 54/130 (41%), Gaps = 11/130 (8%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN---RFQEITVKEKGTIKLVARVTRN 859
+ +KA N G +E S + V +E P + + R I VK + + A VT
Sbjct: 16294 FRVKAVNEIGESEPSLPLNVVIQDDE-VPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGL 16352
Query: 860 PVPSITWYRNNEII-SPSET--ITQ---NFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P+P I W +N +I P++ IT+ + EL I E D G Y ASN G
Sbjct: 16353 PMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRE-DKGTYTVTASNRLG 16411
Query: 914 KSSHGARVTI 923
V +
Sbjct: 16412 SVFRNVHVEV 16421
Score = 34.3 bits (75), Expect = 4.9
Identities = 26/120 (21%), Positives = 52/120 (43%), Gaps = 4/120 (3%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFIN--RFQEITVKEKG-TIKLVARVTRNPVPS 863
A N+ G+ + T + +PP ++++ V G + K+ A + P+P+
Sbjct: 23442 ARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPT 23501
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
I W + ++ +S + + L + + +DSG+Y A N AG+ S V +
Sbjct: 23502 IQWIKGDQELSNTARLEIKSTDFATSLSVKDA-VRVDSGNYILKAKNVAGERSVTVNVKV 23560
Score = 34.3 bits (75), Expect = 4.9
Identities = 25/100 (25%), Positives = 39/100 (39%), Gaps = 4/100 (4%)
Query: 727 IKTGEKEPPQVIEPLKSMIV--RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG 784
IK + EP + + + ++ + G + + G P P +TW +K S
Sbjct: 29565 IKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSIT 29624
Query: 785 DTHSITIL--KPKKVKDEGVYTLKAENSEGIAETSAVITV 822
T T L K D G Y L EN+ G+ S + V
Sbjct: 29625 TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVV 29664
Score = 33.9 bits (74), Expect = 6.4
Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 2/64 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T F+C++ Y + W+ + ++PS D + + V TL +R+V EDAG
Sbjct: 13137 GETATFDCELS-YEDIPVEWYLKGKKLEPS-DKVVPRSEGKVHTLTLRDVKLEDAGEVQL 13194
Query: 584 VAKN 587
AK+
Sbjct: 13195 TAKD 13198
Score = 33.9 bits (74), Expect = 6.4
Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 517 RPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT-LVIREVFP 575
R +H G T++ ++G P P++TW ++ + D V + L IR
Sbjct: 18153 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDR----DAPTKARIDVTPVGSKLEIRNAAH 18208
Query: 576 EDAGTFTCVAKNAAGFASSTTELIV 600
ED G ++ +N AG + + +++V
Sbjct: 18209 EDGGIYSLTVENPAGSKTVSVKVLV 18233
Score = 33.9 bits (74), Expect = 6.4
Identities = 18/81 (22%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G++V+ + G P P I W++ ++ + + ++A+++I++ ++G +
Sbjct: 27814 GTSVKLRAGISGKPAPTIEWYKDDKELQ-TNALVCVENTTDLASILIKDADRLNSGCYEL 27872
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+NA G AS+T + I++ P
Sbjct: 27873 KLRNAMGSASATIRVQILDKP 27893
Score = 33.5 bits (73), Expect = 8.5
Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 15/131 (11%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVL-KIK-TGEKEPPQVIEPLKS---MIVRQGES 751
+ N+K+ ++ + V AVN GE+ +I T +E P+V + + ++ + G
Sbjct: 16695 VPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQ 16754
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKA-------LPTKSDGDT---HSITILKPKKVKDEG 801
+ + A + G P P +W + K KA +P + +T S+ I+ K G
Sbjct: 16755 IRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTG 16814
Query: 802 VYTLKAENSEG 812
Y++ A+N G
Sbjct: 16815 KYSITAKNKAG 16825
Score = 33.5 bits (73), Expect = 8.5
Identities = 31/130 (23%), Positives = 53/130 (40%), Gaps = 9/130 (6%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN-RFQEITVKEKGT-IKLVARVTRNP 860
+ +KA N G +E S T+ EP +FI+ Q+ V + G+ I++ A + P
Sbjct: 16706 FRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRP 16765
Query: 861 VPSITWYRNNEI-------ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P +W + + + Q EN ++I +G Y A N AG
Sbjct: 16766 TPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAG 16825
Query: 914 KSSHGARVTI 923
+ + RV +
Sbjct: 16826 QKTANCRVKV 16835
Score = 33.5 bits (73), Expect = 8.5
Identities = 25/106 (23%), Positives = 47/106 (44%), Gaps = 7/106 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PP P+ + G + +E + P P W +E+V +++V ++D
Sbjct: 19825 LPPKILM-PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVH-KADS--- 19879
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPP 735
S+L I +V + G Y++ A N G + +V+ G +PP
Sbjct: 19880 SSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPP 19925
Score = 33.5 bits (73), Expect = 8.5
Identities = 18/69 (26%), Positives = 31/69 (44%), Gaps = 1/69 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + E V G P P + W + ++ + ++ D + LV ++ D+G +T
Sbjct: 22403 GEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKDSTRRDSGAYTL 22461
Query: 584 VAKNAAGFA 592
A N GFA
Sbjct: 22462 TATNPGGFA 22470
Score = 33.5 bits (73), Expect = 8.5
Identities = 53/198 (26%), Positives = 78/198 (39%), Gaps = 22/198 (11%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G D+ +E + P+P I W G + I+V D+ + L I K
Sbjct: 24168 VQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDL----TTLSIKETHKDD 24223
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G Y + N G+ + I + + + +PP+ P+K V ES+ LS NP
Sbjct: 24224 GGQYGITVANVVGQKTASIEI-VTLDKPDPPK--GPVKFDDV-SAESITLS----WNPPL 24275
Query: 765 TITWCK--NNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYTLK--AENSEG--IA 814
C+ N K T + D S T+ LK K+K Y + AEN G A
Sbjct: 24276 YTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFA 24335
Query: 815 ETSAVITVEEPTEENAEP 832
S I + P +E P
Sbjct: 24336 LESDPIVAQYPYKEPGPP 24353
>AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein.
Length = 26926
Score = 299 bits (733), Expect = 9e-80
Identities = 200/685 (29%), Positives = 321/685 (46%), Gaps = 41/685 (5%)
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL-TIKKV 1350
D + ++ G + L V + P P W + ++ + +D KS T +
Sbjct: 13201 DLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRD----RIGLDIKSTDFDTFLRC 13256
Query: 1351 ENT---DAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENT 1407
EN DAG Y L LEN+CG + + V +LD P PP + EI S + W+ P
Sbjct: 13257 ENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIID 13316
Query: 1408 GNSTIIYYVVEYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
G S II YVV+ ++ + W +V +KT + NL+ SY FR +A NE I D E
Sbjct: 13317 GGSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGE 13376
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITT--------EPNEDIELTCIFGGVPQPKVTWYRD 1518
T + +K ++ P V+ +++++ +P+ D + I G V +
Sbjct: 13377 TRD---AVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGG-SRIIGYVVDFLTEENKW 13432
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE 1578
+ +K+ Y + ++ A N++GE S + + + V+ +
Sbjct: 13433 QRVMKSLSLQYSAKDLTEGKEYT------FRVSAENENGEGTPSEITVVARDDVVAPDLD 13486
Query: 1579 -----DIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
D+ K + + I+G P P V W K + L D ++ + + + +
Sbjct: 13487 LKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVY 13546
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDD 1693
+ ++S + KYTI N AGT +++KV KP P GP+ E++ E++T++W PP DD
Sbjct: 13547 DCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDD 13606
Query: 1694 GGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEAL 1753
GG E+T Y +EK + NN+W+ A + T+ + +L+E EY FRV A+N G E L
Sbjct: 13607 GGSEITNYILEKRDSVNNKWVTCASAVQKT-TFRVTRLHEGMEYTFRVSAENKYGVGEGL 13665
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-K 1812
+SEPIV + DVP + ++SV +TW +K GGSPI Y +E K+
Sbjct: 13666 KSEPIVARHPFDVPD-APPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLL 13724
Query: 1813 WKXXXXX--XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR 1870
WK ++ L+ Y+FR+ A N G P + + + PP +P
Sbjct: 13725 WKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPE 13784
Query: 1871 NFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENI 1930
V T SVTL WTEP+ +GG +T YI+E + + KSW K V + ++
Sbjct: 13785 ---VINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDL 13841
Query: 1931 KEKDEIIFRISAENTVG-VSLPTES 1954
E + FRI A+NT G +S P+ES
Sbjct: 13842 VEGGKYEFRIRAKNTAGAISAPSES 13866
Score = 290 bits (711), Expect = 4e-77
Identities = 346/1472 (23%), Positives = 590/1472 (40%), Gaps = 117/1472 (7%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F+K V E I L C V+ P ++ W EEI+ + E +L
Sbjct: 5968 FTKNLANIEVSETDTIKLVCE-VSKPGAEVIWYKGDEEIIETGRYEILTEGRKR----IL 6022
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
I N G Y + + K+K E + +P +++ + +GE
Sbjct: 6023 VIQNAHLEDAGNYNCRLPSSRTDG------KVKVHELAAEFISKP-QNLEILEGEKAEFV 6075
Query: 756 AQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ P + W +++K +++ +DG + ++K ++D G Y + G
Sbjct: 6076 CSISKESFP-VQWKRDDKTLESGDKYDVIADGKKR-VLVVKDATLQDMGTYVVMV----G 6129
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
A +A +TV E + ++ VKE+ + V + W+RN E
Sbjct: 6130 AARAAAHLTVIEKLR-------IVVPLKDTRVKEQQEVVFNCEVNTEGAKA-KWFRNEEA 6181
Query: 873 ISPSET--ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-SHGARVTIDVEKVT 929
I S I Q + + ++D D +Y +N G++ A + ++ E +
Sbjct: 6182 IFDSSKYIILQKDLVYTLRIRDAHLD---DQANYNVSLTNHRGENVKSAANLIVEEEDLR 6238
Query: 930 FVKHLQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
V+ L K ET E K+V C+ + V+ KW N +E+ D+R + +
Sbjct: 6239 IVEPL-KDIETMEKKSVTFWCKVNRLNVTLKWTKNGEEVP-FDNRVSYRVDKYKHMLTIK 6296
Query: 989 XXXX-DVG-VIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD 1046
D G I +D+ + +L++ E EF+ L+D V E D A+ +++ E A+
Sbjct: 6297 DCGFPDEGEYIVTAGQDKSVAELLII-EAPTEFVEHLEDQTVTEFDDAVFSCQLSREKAN 6355
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELP 1106
V W R+G IK K KY FEK G I +L I++ + DE EY+C + D A + V E+P
Sbjct: 6356 VKWYRNGREIKEGK-KYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIP 6414
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
EII Q+ G F EL K V+W ++ + + Q+ +GK +L+I
Sbjct: 6415 VEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQIC 6474
Query: 1167 DCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
D D GEY + + A L + ++ + LV + LT+ +P +
Sbjct: 6475 DIKPRDQGEYRFIAKDKEARAKLELAAAP---KIKTADQDLV-VDVGKPLTMVVPYDAYP 6530
Query: 1226 --DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKV 1281
+ W+K+ E T+ + ++ + I + + D+ Y VL + K+ + +
Sbjct: 6531 KAEAEWFKEN---EPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINL 6587
Query: 1282 EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPND--EWIVNSKIIKKCKHTKPSID 1339
+V++ P + + E +V+L + + ++V + IK+ +
Sbjct: 6588 KVIDVPGPVRNLEVTETFD--GEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDR 6645
Query: 1340 SKSASLTIKKVENTDAG-IYKLRLENNCGHAD-VEMNVTI-----LDKPSPPGKPNILEI 1392
++S T+ ++ ++++ N G + VE + + D P PP I ++
Sbjct: 6646 AESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDV 6705
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYR 1450
+ +++ W+ PE G + I YV+E ++ + W + + S + ++ Y
Sbjct: 6706 NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYS 6765
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE-DIELTCIFGGVP 1509
FR A N + + S T + KV + SP V + T + E GG P
Sbjct: 6766 FRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSP 6825
Query: 1510 ----------QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
+ K W R KL + TY+ Y+ A N G
Sbjct: 6826 ILGYIIERCEEGKDNWIRCNMKL-VPELTYK------VTGLEKGNKYLYRVSAENKAGVS 6878
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE------GIPPPEVIWYKNGNKL 1613
+ S ++G + K G E +V I G P P W L
Sbjct: 6879 DPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVL 6938
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
E + T + + I +RS YT++ N T S E+ + V +PS P+ +
Sbjct: 6939 ETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPK-EL 6997
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNE 1733
+I+++SV + W+PP DDGG LT Y +EK E W KV D D+E + + L +
Sbjct: 6998 KFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLE-FTVPDLVQ 7056
Query: 1734 NCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE 1792
EY+F+V A+N G E A EP+ + T VP N S+++TW P +
Sbjct: 7057 GKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTAN-SIFLTWDPPK 7115
Query: 1793 KNGGSPIIDYKVEIKQEGK-KWKX-XXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+GGS I Y VE G KW + L Y +R+ A N G S P
Sbjct: 7116 NDGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKP 7175
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK 1910
++I T P + + + K P + G P E K
Sbjct: 7176 SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKP------EPKI---- 7225
Query: 1911 SWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATV----- 1965
+WTK + IEN+ +K + S + G + E+ +V A V
Sbjct: 7226 TWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVL 7284
Query: 1966 --PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
P PP A +I V + + +W P DGG+ + Y + R +W ++ V
Sbjct: 7285 DKPGPPAA-FDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSST-VKD 7342
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
F L N Y+ R+ A N G+ EP+++
Sbjct: 7343 TNFKATKLIPNKEYIFRVAAENMYGVGEPVQA 7374
Score = 283 bits (695), Expect = 4e-75
Identities = 321/1444 (22%), Positives = 574/1444 (39%), Gaps = 102/1444 (7%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G +C L + + + W KG+++ P + + E +H L + +VK
Sbjct: 5710 VTAGETATFDCEL-SYEDIPVEWYLKGKKLEPSDKVVPRSEGKVH----TLTLRDVKLED 5764
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP-QVIEPLKSMIVRQGESVILSAQVVGNPR 763
G + A + + A+L + KEPP + +PL+ V +G + +L +V
Sbjct: 5765 AGEVQLTAKDFKTHANLFV--------KEPPVEFTKPLEDQTVEEGATAVLECEV-SREN 5815
Query: 764 PTITWCKNNKPV---KALPTKSDGDTHSITI--LKPKKVKDEGVYTLKAENSEGIAETSA 818
+ W KN + K +DG + I P+ +K YT A++ + TS
Sbjct: 5816 AKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIK---TYTCDAKDFK----TSC 5868
Query: 819 VITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET 878
+ V P E F+ ++ V+EK + ++R + W+++ I +
Sbjct: 5869 NLNVVPPHVE------FLRPLTDLQVREKEMARFECELSRENA-KVKWFKDGAEIKKGKK 5921
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
G + +++ N D +Y C + ++S +T+ E+ F K+L +
Sbjct: 5922 YDIISKGA-VRILVINKCLLDDEAEYSCEVRTA--RTS--GMLTVLEEEAVFTKNLA-NI 5975
Query: 939 ETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
E E T+ L C+ S WY +EI EI+ EGR D G
Sbjct: 5976 EVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNY 6035
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
C + T + V E EFI K Q+ E+ E + A I+ E+ V W+RD + ++
Sbjct: 6036 NCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLE 6095
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
+KYD G R L +++ ++ D G Y ++ A +TV+E I+ L++ +
Sbjct: 6096 -SGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTR 6153
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + + F E+ A +WF++ I S+ + L+I D LDD Y+
Sbjct: 6154 VKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYN 6213
Query: 1178 CEVGNS-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
+ N K A L VEE + L + + + + ++ + + W K
Sbjct: 6214 VSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWC-KVNRLNVTLKWTKN 6272
Query: 1233 KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
+ + + D K L I+ C D+ EY KS +L + +E P + V+
Sbjct: 6273 GEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLI--IEAPTEFVE 6330
Query: 1293 YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
+ + + D + N +W N + IK+ K K D L IK
Sbjct: 6331 HLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRL 6389
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTI 1412
D Y +E+ A + + ++ PP +ILE + + + ++
Sbjct: 6390 DDECEYACGVEDRKSRARLFVEEIPVEIIRPP--QDILEAPGADVVFLAELNKDKVEVQW 6447
Query: 1413 IYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
+ + + D + +S I + Q + YRF I+ E +
Sbjct: 6448 LRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRF---------IAKDKEARAKLE 6498
Query: 1473 VIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA-TYEN 1531
+ KI++ +++ + + + + + P+ + W+++ + L T T
Sbjct: 6499 LAAAPKIKTAD-----QDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAE 6553
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH--KVGDE 1589
+ YK + N HG+ E + + P + N ++ + +V
Sbjct: 6554 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPG-PVRNLEVTETFDGEVSLA 6612
Query: 1590 WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSK-YTIEA 1647
W G ++I Y + K + + T S + L++ + + A
Sbjct: 6613 WEEPLTDGG---SKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSA 6669
Query: 1648 SNTAGTSS-VEVTLKV-----YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
N GT VE V YD P P V + +++R V++ W+PP DGG E+T Y
Sbjct: 6670 RNRVGTGEPVETDNPVEARSKYDVPGPPLN-VTITDVNRFGVSLTWEPPEYDGGAEITNY 6728
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV-I 1760
IE + + RW V + + + + E EY FRV AQN +G + + P V +
Sbjct: 6729 VIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKV 6788
Query: 1761 KTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KW--KXXX 1817
++ PS + SV + W P K+GGSPI+ Y +E +EGK W
Sbjct: 6789 ADPIERPSPPVNLTSSDQTQS-SVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMK 6847
Query: 1818 XXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN-FVVSE 1876
++ L Y +R+ A N+ G S P +T P+ + F
Sbjct: 6848 LVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGL 6907
Query: 1877 STSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEI 1936
+ P + P + K ++ K+ T+ + E I + D+
Sbjct: 6908 EVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTL-SAYAELVISPSERSDKG 6966
Query: 1937 IFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM--VGSNIVMTSWGTPEWDG 1994
I+ + EN V +++ E V + P+AP E++ + + V +W P+ DG
Sbjct: 6967 IYTLKLENRV--------KTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDG 7018
Query: 1995 GAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
G+PL GY + R+V++ W +V V L+F + DL + Y+ ++ ARN+ G EP
Sbjct: 7019 GSPLTGYVVEKREVSRKTWTKVMDF-VTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAY 7077
Query: 2055 SDEP 2058
DEP
Sbjct: 7078 VDEP 7081
Score = 276 bits (676), Expect = 7e-73
Identities = 202/711 (28%), Positives = 312/711 (43%), Gaps = 35/711 (4%)
Query: 1287 PPKIV---DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK-- 1341
PP+++ + RE IK G + L + P P W K + TK ID
Sbjct: 10718 PPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTW----KKEDRDAPTKARIDVTPV 10773
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
+ L I+ + D GIY L +EN G V + V +LDKP PP + EI S + W
Sbjct: 10774 GSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTW 10833
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSI-QNLKTNSSYRFRAYAVNEVD 1460
EP + G S I YVVE +++ + +W + +K ++ ++L + Y FR A N+
Sbjct: 10834 KEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYG 10893
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF----GGVPQPK--VT 1514
ET + K + + P K L ++ + E + L GG P V
Sbjct: 10894 RGPFVETPKPIKALDP--LHPPGPPKDLHHVDVDKTE-VSLVWNKPDRDGGSPITGYLVE 10950
Query: 1515 WYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
+ +G + T N K G +T+ + Q+K V
Sbjct: 10951 YQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVP 11010
Query: 1574 TISNEDIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV 1629
D+K K G A+I G+P P W +G++++ D+ Y + T +SV
Sbjct: 11011 PSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV 11070
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKP 1689
+ IK R + +Y I SN AG+ +V V L V D P P GP+ + +++ E +TI W+P
Sbjct: 11071 LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQP 11130
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGF 1749
P DDGG + Y +EK + + W V+ + I L + CEY+FRV A+N +G
Sbjct: 11131 PKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLK-IPHLQKGCEYVFRVRAENKIGV 11189
Query: 1750 SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQE 1809
L+S P V K PS +N + ++W + +GGSPI Y +E ++
Sbjct: 11190 GPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT-VSWTLPKSDGGSPITGYYMERREV 11248
Query: 1810 GKKWKXXXXX--XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS 1867
KW R+ L TY+FR++A N G S P S D I + + PP
Sbjct: 11249 TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPG 11308
Query: 1868 QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC- 1926
P N + + + + L WT+P S+GGSPI Y++E + W +I + C
Sbjct: 11309 PPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINK--DELIRQCA 11366
Query: 1927 --IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ + E +E FRI A N VG P E + K + PP L++
Sbjct: 11367 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAK--DILHPPEVELDV 11415
Score = 262 bits (643), Expect = 7e-69
Identities = 222/868 (25%), Positives = 365/868 (42%), Gaps = 58/868 (6%)
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP 1287
TW V+E ++ + + L+I D+ YT L + T +++V
Sbjct: 6930 TWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 6989
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-------WIVNSKIIKKCKHTKPSIDS 1340
E ++ D+T + + P+D+ ++V + + + TK
Sbjct: 6990 RPSAPKELKF-----GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFV 7044
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCG-----HADVEMNV-TILDKPSPPGKPNILEIDS 1394
T+ + ++K+ N CG + D +N+ T P PP + +
Sbjct: 7045 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTA 7104
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRA 1453
+SI + WD P+N G S I Y+VE + +W++ + + +T+ + L+ Y +R
Sbjct: 7105 NSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRV 7164
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVE-KPLKNITTEPNEDIELTCIFGGVPQPK 1512
A+N S S TE + + + ++ K L +T + IEL G P+PK
Sbjct: 7165 KALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPK 7224
Query: 1513 VTWYRDGKKLKTAK-ATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+TW + LK K T EN + Y A N G V +
Sbjct: 7225 ITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVL 7284
Query: 1569 QKP-------VITISNEDI----KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK 1617
KP + ++NE G + V+E +W+K + +++
Sbjct: 7285 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKD-- 7342
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG----TSSVEVTLKVYDKPSKPEGPV 1673
T + T +I KE + + A N G + +T K P P +
Sbjct: 7343 ----TNFKATKLIPNKEY------IFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRL 7392
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNE 1733
+I++++VT+ W P DDGG +T Y +E+ +PD ++W++ + TY ++ L
Sbjct: 7393 EPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTN 7452
Query: 1734 NCEYMFRVIAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE 1792
+Y FRV+A+N G + +S EPI+IK +D P + SV + W E
Sbjct: 7453 KKKYRFRVLAENLAGPGKPSKSTEPILIKDPID-PPWPPGKPTVKDVGKTSVRLNWTKPE 7511
Query: 1793 KNGGSPIIDYKVEIKQEG-KKW-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+GG+ I Y +E+ + G +W + + L Y FR+ A N+ G S P
Sbjct: 7512 HDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEP 7571
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK 1910
D + + L PPS PR V T + LKWT PE +GGSPITNYI+E + V+ K
Sbjct: 7572 SEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRK 7631
Query: 1911 SWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHA-TVPSPP 1969
W + T + + + E +FR++AEN +G S TE + L K T P PP
Sbjct: 7632 GWQTVDTTVKDT-KCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPP 7690
Query: 1970 TAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIR 2029
A L + V V W P+ DGG P+ Y I ++ T W++ GK F +
Sbjct: 7691 YA-LAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVT 7749
Query: 2030 DLSENHTYMIRIYARNEIGLSEPLESDE 2057
D+ E ++ A NE G+ P E E
Sbjct: 7750 DVIEGTEVQFQVRAENEAGVGHPSEPTE 7777
Score = 261 bits (640), Expect = 2e-68
Identities = 196/695 (28%), Positives = 303/695 (43%), Gaps = 41/695 (5%)
Query: 1282 EVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SI 1338
E +E P +D E + I+ G + L V + P P +W K+ + + +
Sbjct: 16438 EKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW---GKVDGEIRDAAIIDV 16494
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
S SL + V D+G Y L LEN+ G + V +LD PSPP + EI S++
Sbjct: 16495 TSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVS 16554
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVN 1457
I W+ P G S I Y+VE +E + +V N K I L+ SY FR A N
Sbjct: 16555 ITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAEN 16614
Query: 1458 EVDISDASETTEYYKVIKETKIQSP-TVEKPLKNIT----TEPNEDIELTCIFGGVP-QP 1511
E I ++T + KV + + TV+ +N T+P D I V Q
Sbjct: 16615 EYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQA 16674
Query: 1512 KVTW-YRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET-SCVVGIQQ 1569
K + + + ++K+ +A N ++ +A N+ G + S V I
Sbjct: 16675 KHSEKWSECARVKSLQAVITN--------LTQGEEYLFRVVAVNEKGRSDPRSLAVPIVA 16726
Query: 1570 KPVITISNEDIKQKH-----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
K ++ D+K +VG + + I G P P + W K+G L+ N+T
Sbjct: 16727 KDLVI--EPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDS 16784
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + IKE + +Y I +N G + + + DKP P+GPV ++S ES+T
Sbjct: 16785 LDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESIT 16844
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
+ W PPL GG ++T Y ++K + W + A V R T + KL EY FR+ A
Sbjct: 16845 LSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVAR--TTLKVTKLKTGTEYQFRIFA 16902
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
+N G S ALES+PIV + P I +S+ I W NGGSP+I Y
Sbjct: 16903 ENRYGQSFALESDPIVAQYPYKEPG-PPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYH 16961
Query: 1804 VEIKQEGK-KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
+E K+ W + Q L Y+FR+YA N +G + +
Sbjct: 16962 LERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVAR 17021
Query: 1861 KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG 1920
PP P +V + +TL+WT+P +GGS IT YI+E + + W K
Sbjct: 17022 DPCDPPGTPEPIMVKRN---EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNV 17078
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVG-VSLPTES 1954
+ + + E FR+ A+N G +S P++S
Sbjct: 17079 IETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDS 17113
Score = 256 bits (627), Expect = 6e-67
Identities = 198/757 (26%), Positives = 326/757 (43%), Gaps = 35/757 (4%)
Query: 1218 VEIPDETLDVTWYK--KKSVIEDTEKFTLISDVK---KRTLIIRKCTEDDQCEYTCVLLD 1272
+E+ ++ D WY+ + I +TE FT + D+K K + + EY+ + +
Sbjct: 22881 LEMQEKDTD-QWYRVHTNATIRNTE-FT-VPDLKMGQKYSFRVAAVNVKGMSEYSESIAE 22937
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
+ ++++ +E D ++ I+ G+ + L+V P P W + + I
Sbjct: 22938 IEPVERIEIPDLELAD---DLKKTVTIRAGASLRLMVSVSGRPPPVITW--SKQGIDLAS 22992
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ L + KV DAG Y + EN G + V + D P P + E+
Sbjct: 22993 RAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEV 23052
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRF 1451
S+ I W+ P G + + Y+VE +E + +V +KT I L + Y F
Sbjct: 23053 SRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYF 23112
Query: 1452 RAYAVNEVDISDASETTEYYKV----IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
R N I + ET++ V + K++ V K + E + + G
Sbjct: 23113 RVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGY 23172
Query: 1508 VPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE---TSCV 1564
V + K+ T K T ++ A N+ G E T
Sbjct: 23173 VLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYL---FRIRAQNEKGVSEPRETVTA 23229
Query: 1565 VGIQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
V +Q P I +S K H G + I G PPP W+ G+KL +
Sbjct: 23230 VTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVT 23289
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
+ T K + + I+E + +YT+E N GT+S + + + DKP P GP+ + EI
Sbjct: 23290 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDA 23349
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD-VDRDVETYCIQKLNENCEYMF 1739
S+TI W+PP DGG L+ Y +E+ + W+ V++ V R T+ +L E EY+F
Sbjct: 23350 TSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTR--STFKFTRLTEGNEYVF 23407
Query: 1740 RVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
RV A N G L+SE I ++++ +P + + + +TW+P E +GGS +
Sbjct: 23408 RVAATNRFGIGSYLQSEVIECRSSIRIPG-PPETLQIFDVSRDGMTLTWYPPEDDGGSQV 23466
Query: 1800 IDYKVEIKQ-EGKKWKXXXXXXXXXARIQK--LSINTTYQFRIYARNEIGTSLPYTSDDK 1856
Y VE K+ +W R + L+ Y+ R+ A N G+ P
Sbjct: 23467 TGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKP 23526
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
I + PP +P+N V+++T SV+L W+ PE GGS +T Y+IE + V WTK
Sbjct: 23527 IVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCN 23586
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
T + E+ + ++ + E FR+ A N G P E
Sbjct: 23587 TTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAE 23623
Score = 248 bits (606), Expect = 2e-64
Identities = 190/706 (26%), Positives = 301/706 (42%), Gaps = 43/706 (6%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK---HTKPS-----IDSKSASLTIKKVE 1351
K GS + + + P P W + K K K H P S+ + I + +
Sbjct: 9326 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECK 9385
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+ G Y + +N G V ++D P PP + +I S + W P++ G
Sbjct: 9386 RSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDR 9445
Query: 1412 IIYYVVEYQEIDTTEWISVK-NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE- 1469
I YV+E + ID W V + T + +L + Y FR A N I ET +
Sbjct: 9446 IKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQR 9505
Query: 1470 ------YYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
Y K++ + K +++ +P ++ + + + + + W G K +
Sbjct: 9506 TTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVEC-LAWDPTGTKKE 9564
Query: 1524 TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ--QKPVITISNE 1578
+ + ++ A N G + S VG Q+P + S
Sbjct: 9565 AWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSI- 9623
Query: 1579 DIKQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE-------YNITTKEKTSV 1629
D+K+ +V G + A I+G+P P + W+K K ++KE N + T
Sbjct: 9624 DLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCT 9683
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKP 1689
+ I + +RS + YTI A N GT+S E+ L V +P P GP+ +S + +T+ W P
Sbjct: 9684 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFP 9743
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGF 1749
P DDGG ++T Y IEK E + W+ V+ ++ TY I KL E EY+FR++AQN G
Sbjct: 9744 PKDDGGSKITNYVIEKREANRKTWVHVSSEPKEC-TYTIPKLLEGHEYVFRIMAQNKYGI 9802
Query: 1750 SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ- 1808
E L+SEP + VP + S+ + W E +GGSP+ Y +E+K
Sbjct: 9803 GEPLDSEPETARNLFSVPG-APDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDT 9861
Query: 1809 EGKKWK------XXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKT 1862
K+WK ++ L + YQFR+YA N G D T
Sbjct: 9862 TSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDP 9921
Query: 1863 LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
+ PP P V++ T S L+W+ P +GGS +T YI+E+K + W K
Sbjct: 9922 IAPPGPPFP-KVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRG 9980
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
+ + +KE FR+SA N G+ P E V +E + SP
Sbjct: 9981 TKLVVTGLKEGAFYKFRVSAVNIAGIGEPGEVTDV-IEMKDRLVSP 10025
Score = 247 bits (605), Expect = 3e-64
Identities = 188/685 (27%), Positives = 304/685 (44%), Gaps = 31/685 (4%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKII-KKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
K G DV +L+ ++ P P W + K + +++ + DS S LTI +V D G Y
Sbjct: 20787 KAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSL-LTIPQVTRNDTGKY 20845
Query: 1359 KLRLENNCGHADVE-MNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
L +EN G ++V +LD P+ K + + ++ + WD P G S II YV+
Sbjct: 20846 ILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVI 20905
Query: 1418 EYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
E ++ W V + + T + +L + + FR A NE+ I + ETTE +K
Sbjct: 20906 EKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTE---PVKA 20962
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTC--IFGGVPQPKVTWYRDGKKLKT-AKATYENRX 1533
++ +P + +K+ +T+ + + T GG + R GK +T + A
Sbjct: 20963 AEVPAPIRDLSMKD-STKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTC 21021
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQ------KHKVG 1587
++ A N+ G + + I K +I D+ ++G
Sbjct: 21022 EIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIG 21081
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
+ +G P P + W K+G L+ + + E + IK K+ H KYT+
Sbjct: 21082 HNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVIL 21141
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
N +V +T+ PSKP+GP+ EI +SV + W P D+GG E+T Y+IEK E
Sbjct: 21142 DNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRE 21201
Query: 1708 PDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV 1766
W V + V R T+ + L ++ EY FRV A+N G S+ L S IV K +
Sbjct: 21202 TSQTNWKMVCSSVAR--TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRI 21259
Query: 1767 PSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXX--XXXX 1823
P + ++ + +TW +GGS + + VE K+ W+
Sbjct: 21260 PG-PPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGRE 21318
Query: 1824 ARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG-KTLTPPSQPRNFVVSESTSRSV 1882
R L YQFR+YA N G S P + K T+ + PP P +++ + T ++
Sbjct: 21319 YRATGLVEGLDYQFRVYAENSAGLSSP-SDPSKFTLAVSPVDPPGTP-DYI--DVTRETI 21374
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TLKW P +GGS I Y IE K + W + S ++ + + D FRI A
Sbjct: 21375 TLKWNPPLRDGGSKIVGYSIE-KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIA 21433
Query: 1943 ENTVG-VSLPTESQSVRLEKHATVP 1966
N VG +S P++S + + + VP
Sbjct: 21434 RNAVGTISPPSQSSGIIMTRDENVP 21458
Score = 245 bits (600), Expect = 1e-63
Identities = 188/708 (26%), Positives = 303/708 (42%), Gaps = 35/708 (4%)
Query: 1287 PPKI---VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
PP+I D + ++ + + L V + P+P +W I+ + + S
Sbjct: 18607 PPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTD--RAQIEVTSSFT 18664
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDE 1403
L I V D+G Y L LENN G +NV +LD PS P I E+ S+ + W+
Sbjct: 18665 MLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEP 18724
Query: 1404 PENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
P G + I Y+VE +E + ++ N TKT I+NL+ SY FR A NE I
Sbjct: 18725 PLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIG 18784
Query: 1463 DASETTEYYKV----IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
+ETTE KV + ++ V + I E E + I G V + + +
Sbjct: 18785 LPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQT---KG 18841
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC----VVG--IQQKPV 1572
+K T T ++ A N+ G + V+ I+ KP
Sbjct: 18842 SEKWSTC--TQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPS 18899
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + K + ++ + +G P V W K+G L+ N+++ + + + I
Sbjct: 18900 VELPFHTFNVKAR--EQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSI 18957
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLD 1692
KE + Y + SN+AG+ +V +T+ V D+P P GP+ + E+S +S+TI W PP
Sbjct: 18958 KEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPP-GPIRIDEVSCDSITISWNPPEY 19016
Query: 1693 DGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
DGG +++ Y +EK E + W V+ + I +L EY FRV A+N G S
Sbjct: 19017 DGGCQISNYIVEKKETTSTTWHIVSQAVART-SIKIVRLTTGSEYQFRVCAENRYGKSSY 19075
Query: 1753 LESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK- 1811
ES +V + P ++ +TW +GGS +I Y +E K+
Sbjct: 19076 SESSAVVAEYPFSPPGPPGTPKVVHA-TKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSI 19134
Query: 1812 KWKXX--XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQP 1869
W ++ L Y++R+YA N G S + + PP QP
Sbjct: 19135 LWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQP 19194
Query: 1870 RNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIEN 1929
V+ T +SV+LKW++P +GG+ IT YI+E + + W K +
Sbjct: 19195 E---VTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTE 19251
Query: 1930 IKEKDEIIFRISAENTV-GVSLPTESQSVRLEKHATVPSPPTAPLEIR 1976
+ E FR+ A N VS P+ES + K PP ++++
Sbjct: 19252 LTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDV--EPPRVMMDVK 19297
Score = 243 bits (594), Expect = 6e-63
Identities = 176/609 (28%), Positives = 276/609 (45%), Gaps = 30/609 (4%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
DKPS PG+ IL I S+ + W++PE G I+ Y VEY++ + W + + I
Sbjct: 23932 DKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDK 23991
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
Q +I L + Y FR +A NE +S T K K T ++P + K +K++TT+
Sbjct: 23992 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKT-KLTSGEAPGIRKEMKDVTTKLG 24050
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXXXXXXXXXXX-YKCIA 1552
E +L+C G P P + WYR GK+L + K + + R Y CIA
Sbjct: 24051 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24110
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIKQKH--KVGDEWLVTAVIEGIPPPEVIWYKNG 1610
N+ GEVETS + +Q P +K+K+ VG + + G P P + W+
Sbjct: 24111 TNEVGEVETSSKLLLQATPQFH-PGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQ 24169
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKR-SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
L+N + I E + + +K ++R +H+ KY ++ SN GT + +++ DKP KP
Sbjct: 24170 KLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKP 24229
Query: 1670 EGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQ 1729
GP+++ + + S I WKPP DDGG +T Y +EK E ++ V T I
Sbjct: 24230 TGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIV 24289
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW 1788
L EN Y FRV AQN G S+ LE S ++IK+ + P + +S + W
Sbjct: 24290 NLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPG-APGKPTITAVTKDSCVVAW 24348
Query: 1789 FPSEKNGGSPIIDYKVEIKQEGK--KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNE 1844
P +GG+ I +Y +E K+E K KW ++ L Y+FR+ N
Sbjct: 24349 KPPASDGGAKIRNYYLE-KREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENL 24407
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQP------RNFVVSESTSRSVTLKWTEPESNGGSPIT 1898
G S + IT K+ P P RN V ++ ++ K T PI
Sbjct: 24408 GGESEWSEISEPIT-PKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVT----GHPKPIV 24462
Query: 1899 NYIIEFKTVKGKSWT-KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
+ + K + +I G H+ I ++ + D ++++ A N G T S V
Sbjct: 24463 KWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24522
Query: 1958 RLEKHATVP 1966
+ +P
Sbjct: 24523 EVPAKIHLP 24531
Score = 242 bits (593), Expect = 8e-63
Identities = 215/796 (27%), Positives = 348/796 (43%), Gaps = 54/796 (6%)
Query: 1195 SINFTLRLPEFILVPANTDAYLTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKR 1251
+I +L+LP F L +EIP +++W K ++ T + +
Sbjct: 17812 TIQPSLKLP-FNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST 17870
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
L I++ +DD +YT ++ T L V V+E P V R S +++
Sbjct: 17871 VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVG---PVRFDEVSADFVVI 17927
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL---TIKKVENTDAGIYKLRL--EN 1364
++ P +++ I++K T + SA++ TIK + Y+ R+ EN
Sbjct: 17928 SWEP-PAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAEN 17986
Query: 1365 NCGH-ADVEMNVTILD----KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEY 1419
G A ++ I+ +P PPG P + I + + W EP N G + II Y +E
Sbjct: 17987 RYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQ 18046
Query: 1420 QEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKET 1477
+E ++ W+ + I T+ L Y F+ A N V I S+ +E + +
Sbjct: 18047 KEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF--VARD 18104
Query: 1478 KIQSPTVEKPLKNITTEPNEDIELT--CIFGGVPQPKVTWYRDGKKL----KTAKATYEN 1531
P +P + T N ++ GG K+T Y KK + KA++ N
Sbjct: 18105 PCDPPG--RPEAIVITRNNVTLKWKKPAYDGG---SKITGYIVEKKDLPDGRWMKASFTN 18159
Query: 1532 RXXXXXXXXXXXXXXXY--KCIAFNDHGEV-ETSCVVG-IQQKPVITISNEDIKQKHK-- 1585
Y + IA N G E S G I + I N + K+K
Sbjct: 18160 VLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDV 18219
Query: 1586 ----VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNI-TTKEKTSVIRIKELKRSH 1639
G+ +++ A I G P P+V+W K+G +LE I +T +KT+++ +K+ R+
Sbjct: 18220 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLV-VKDCIRTD 18278
Query: 1640 SSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELT 1699
+Y ++ SN GT S+ +T+KV D+P PEGP+ + ++ E + W PPL DGG ++
Sbjct: 18279 GGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANIS 18338
Query: 1700 KYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV 1759
Y IEK E W +V+ + Y + KL EY+FRV+A N G E LES P+
Sbjct: 18339 HYIIEKRETSRLSWTQVS-TEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVT 18397
Query: 1760 IKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWK--XX 1816
P I +S+ +TW +GG+ I Y +E + +EG +W
Sbjct: 18398 ACNPYK-PPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNK 18456
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE 1876
R+ L+ +Y+FR+ A N G P L PP P N V++
Sbjct: 18457 KTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTD 18516
Query: 1877 STSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV-TVGGSVHEHCIENIKEKDE 1935
++ SV+L W++P +GG+P+ Y++E K WT G + + +KE E
Sbjct: 18517 TSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTE 18576
Query: 1936 IIFRISAENTVGVSLP 1951
FRI A N+ GV P
Sbjct: 18577 YNFRICAINSEGVGEP 18592
Score = 239 bits (585), Expect = 8e-62
Identities = 195/695 (28%), Positives = 293/695 (42%), Gaps = 36/695 (5%)
Query: 1280 KVEVVEFPPKI---VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
K E PP+I D + I+ + L V + P P +W + K
Sbjct: 15353 KAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGE----SLDKA 15408
Query: 1337 SIDSKSAS--LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
SI+S S+ L + V D+G Y L +EN+ G +NV +LD P PP + E+
Sbjct: 15409 SIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTK 15468
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTSIQNLKTNSSYRFRA 1453
+S+ + WD P G S I Y+VE +E + +V N KT + L+ SY FR
Sbjct: 15469 TSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRV 15528
Query: 1454 YAVNEVDISDASETTEYYKVIKET----KIQSPTVEKPLKNITTEPNEDIELTCIFGGVP 1509
A NE I +ET E K + KI V + +++ E E + I G +
Sbjct: 15529 LAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIV 15588
Query: 1510 QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG--EVETSCVVGI 1567
+ + T K T ++ A N+ G + V I
Sbjct: 15589 EMQTKGSDKWATCATVKVT-----EATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVI 15643
Query: 1568 QQKPVITISNEDIKQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE 1625
+ VI + + + V G++ V G P P V W+K+ L+ N + E
Sbjct: 15644 AKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTE 15703
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
S++ IK+ R Y ++ +N+AG + + + V DKP P GPV M E++ +S+T+
Sbjct: 15704 NNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITL 15763
Query: 1686 EWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
W PP DGG + Y +EK + W I A V R C +L CEY FR+ A+
Sbjct: 15764 SWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKAC--RLKTGCEYQFRIAAE 15821
Query: 1745 NPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKV 1804
N G S L SEP V + VP +S+ + W +GGS +I Y +
Sbjct: 15822 NRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLS-SRDSMEVQWNEPISDGGSRVIGYHL 15880
Query: 1805 EIKQEGK-KWKXXXXXXXXXARIQK--LSINTTYQFRIYARNEIGTSLPYTSDDKITIGK 1861
E K+ W + + L Y+FR+ A N +G P +
Sbjct: 15881 ERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARD 15940
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
PP +P +V T SVTL+W +P +GGS IT YI+E K + W K +
Sbjct: 15941 PCDPPGRPEAIIV---TRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMK-ASFTNI 15996
Query: 1922 VHEHC-IENIKEKDEIIFRISAENTVGV-SLPTES 1954
+ H + + E FR+ A N GV S P+ES
Sbjct: 15997 IDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSES 16031
Score = 238 bits (583), Expect = 1e-61
Identities = 195/762 (25%), Positives = 325/762 (42%), Gaps = 47/762 (6%)
Query: 1219 EIPDETLDVTWYKKKSVIEDTEK-FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
+I D + D W + + + K FT+ S + + R C ++ + A+
Sbjct: 12041 KIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQ----VGIGRPAELKE 12096
Query: 1278 KLKVEVVEFPPKIVDYEREYR----IKRGSDVTLLVDYQAFPQPNDEW--IVNSKIIKKC 1331
+K + + PP+I D + R ++ G + L + P P W + +++K
Sbjct: 12097 AIKPKEILEPPEI-DLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRK- 12154
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
+ + A L I D+G Y L L N G V +NV +LD P P + +
Sbjct: 12155 --GQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSD 12212
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTSIQNLKTNSSYR 1450
+ +S ++ W PEN G S + +Y+VE +E D W +V + KT + NL + Y
Sbjct: 12213 VTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYY 12272
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI----FG 1506
FR AVNE ++ + V+ + P + L+ +T L + G
Sbjct: 12273 FRVTAVNEYGPGVPTDVPK--PVLASDPLSEPDPPRKLE-VTEMTKNSATLAWLPPLRDG 12329
Query: 1507 GVP-QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYK--CIAFNDHG-----E 1558
G +T YR+ ++ Y YK A N G E
Sbjct: 12330 GAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPRE 12389
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
E Q P + E I K G + + A + G P P W K +++
Sbjct: 12390 AEGVYEAKEQLLPPKILMPEQITIK--AGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSH 12447
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
+ + +S++ IK++ R S Y++ A N++GT + ++ + V D P P+ P + +I
Sbjct: 12448 LAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDI 12507
Query: 1679 SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWI-KVADVDRDVETYC-IQKLNENCE 1736
++ ++ W PL+DGG +T Y +EK + W+ +A V +T C + KL E
Sbjct: 12508 DADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASV---TKTSCRVGKLIPGQE 12564
Query: 1737 YMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGG 1796
Y+FRV A+N G SE L S +V + VPS ++ + +++ W + +GG
Sbjct: 12565 YIFRVRAENRFGISEPLTSPKMVAQFPFGVPS-EPKNARVTKVNKDCIFVAWDRPDSDGG 12623
Query: 1797 SPIIDYKVEIKQEGK-KWKXXXXXXXXXARIQKLSI--NTTYQFRIYARNEIGTSLPYTS 1853
SPII Y +E K+ W + Y FRIYA N+ G+S P
Sbjct: 12624 SPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKP 12683
Query: 1854 DDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWT 1913
+ +T + PP +P V++ST V+L W P+ +GGS I Y +E + G W
Sbjct: 12684 TEYVTARMPVDPPGKPEVIDVTKST---VSLIWARPKHDGGSKIIGYFVEACKLPGDKWV 12740
Query: 1914 KIVTVGGSV--HEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
+ T + E+ ++EK + FR A V +S P+E
Sbjct: 12741 RCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSE 12782
Score = 238 bits (583), Expect = 1e-61
Identities = 199/754 (26%), Positives = 323/754 (42%), Gaps = 35/754 (4%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEF 1286
+TW K ++ T + + + TL I++ +DD +Y + + +E+V
Sbjct: 16764 ITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTL 16823
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL- 1345
K + + S ++ + + P + + I++K T D SA++
Sbjct: 16824 D-KPDPPKGPVKFDDVSAESITLSWNP-PLYTGGCQITNYIVQKRDTTTTVWDVVSATVA 16881
Query: 1346 -TIKKVENTDAGI-YKLRL--ENNCGHA-DVEMNVTILD----KPSPPGKPNILEIDSSS 1396
T KV G Y+ R+ EN G + +E + + +P PPG P I S
Sbjct: 16882 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDS 16941
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAY 1454
+ I W EP N G S +I Y +E +E ++ W V I TQ QNL+ Y FR Y
Sbjct: 16942 MVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVY 17001
Query: 1455 AVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG-VPQPKV 1513
A N V + AS+ +E Y + P +P+ E GG + +
Sbjct: 17002 AENIVGVGKASKNSECY--VARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYI 17059
Query: 1514 TWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHGEV-ETSCVVG-IQQ 1569
RD + KA++ N Y + IA N G + + S G I
Sbjct: 17060 VEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITA 17119
Query: 1570 KPVITISNEDIKQKHK------VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITT 1623
K + + + K + G+ + + A + G P P + W + ++E I
Sbjct: 17120 KDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKN 17179
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV 1683
+ +++ +K+ R +Y + ASN AG+ S V +KV D+P PEGPV + ++ E
Sbjct: 17180 TDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKC 17239
Query: 1684 TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
++ W PPL DGG +++ Y +EK E W VA + + + KL E EY+FR++A
Sbjct: 17240 SLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVAS-EVVTNSLKVTKLLEGNEYVFRIMA 17298
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G E LES P+++K +P I +S+ + W + +GGS II Y
Sbjct: 17299 VNKYGVGEPLESAPVLMKNPFVLPG-PPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 17357
Query: 1804 VEIK-QEGKKW--KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
VE + + G +W R+ L+ + Y+FR+ A N G P +
Sbjct: 17358 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKAC 17417
Query: 1861 KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT--V 1918
+ P P N + ++T S+TL W +P +GGS I Y++E + W +IVT
Sbjct: 17418 DPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEW-QIVTPQT 17476
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
G V I + E E R+ A N VG+ T
Sbjct: 17477 GLRVTRFEISKLTEHQEYKIRVCALNKVGLGEAT 17510
Score = 232 bits (568), Expect = 9e-60
Identities = 185/693 (26%), Positives = 284/693 (40%), Gaps = 30/693 (4%)
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
+ R ++ G + + V + P P W ++ +K + + + L I +
Sbjct: 14284 ELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENT--ESFTLLIIPECN 14341
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
D G + + +EN G +NV +LD P P +I S+ + WD P G S
Sbjct: 14342 RYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSR 14401
Query: 1412 IIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
I Y+VE +E + + K + L Y FR A NE I + +ETTE
Sbjct: 14402 ITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTE- 14460
Query: 1471 YKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY-----RDGKKLKTA 1525
+K ++ SP + +IT G K+T Y R G T
Sbjct: 14461 --PVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDG--GSKITGYVIEAQRKGSDQWTH 14516
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV---ETSCVVGIQQKPVITISNEDIKQ 1582
T + ++ +A N G E+ V+ +Q + + I Q
Sbjct: 14517 ITTVKG-LECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQ 14575
Query: 1583 K---HKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSH 1639
K K GD V + G P P V W K L+ + N T ++++ I E RS
Sbjct: 14576 KLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSD 14635
Query: 1640 SSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELT 1699
S Y + A N G +T++V+D P P GP+ E+S + VT W PP +DGG+ ++
Sbjct: 14636 SGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPIS 14695
Query: 1700 KYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
Y +E + D+ W+++A V R TY +L EY FRV AQN G + S I
Sbjct: 14696 NYVVEMRQTDSTTWVELATTVIR--TTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 14753
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXX 1817
V VP + +S+ I+W +GGSPI+ Y VE K+ G W+
Sbjct: 14754 VANYPFKVPG-PPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVS 14812
Query: 1818 XXX--XXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVS 1875
+ L+ Y+FR+ A N G S P + + + PP +P V
Sbjct: 14813 KALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP---VPL 14869
Query: 1876 ESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
T +VTLKW +PE GG IT+YI+E + + W K +E + + E
Sbjct: 14870 NITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAA 14929
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
FR+ A+N G P S + V +P
Sbjct: 14930 YEFRVIAKNAAGAISPPSEPSDAITCRDDVEAP 14962
Score = 232 bits (568), Expect = 9e-60
Identities = 197/760 (25%), Positives = 319/760 (41%), Gaps = 45/760 (5%)
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
+ K R I + D CE T + K+ +L ++ ++++ + ++ G+ +
Sbjct: 21826 EYKFRVSAINGAGKGDSCEVTGTI---KAVDRLTAPELDID---ANFKQTHVVRAGASIR 21879
Query: 1307 LLVDYQAFPQPNDEWIV--NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLEN 1364
L + YQ P P W ++ ++ HT S ++LT++ DAG Y L +EN
Sbjct: 21880 LFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSF----STLTVENCNRNDAGKYTLTVEN 21935
Query: 1365 NCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
N G + V +LD P PPG ++ S + WD P G + I +YVVE +E
Sbjct: 21936 NSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASR 21995
Query: 1425 TEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT 1483
W + + T+ + +L Y FR AVNE + E E + I T + P
Sbjct: 21996 RSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVG---EPYEMPEPIVAT--EQPA 22050
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA----KATYENRXXXXXXX 1539
+ L + T + + ++T Y + K + +A + +
Sbjct: 22051 PPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVER 22110
Query: 1540 XXXXXXXXYKCIAFNDHG-----EVETSCVVGIQQ-KPVIT---ISNEDIKQKHKVGDEW 1590
++ A ND G E +S ++ Q +P I+N+ I K G +
Sbjct: 22111 LVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCK--AGSPF 22168
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
+ I G P P+V W +L+ +ITT + + + +K+ R S +Y + NT
Sbjct: 22169 TIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 22228
Query: 1651 AGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN 1710
AG + VT+ V +P GP+ + +S ES + W P D GG E+T Y +EK E
Sbjct: 22229 AGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGT 22288
Query: 1711 NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
W V + + + L + EY FRV ++N G S+ LES PI+ + VP
Sbjct: 22289 TAWQLVNSSVKRTQIK-VTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPF-VPPSA 22346
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KW--KXXXXXXXXXARIQ 1827
+ ++ I W +GGS II Y VE K+ W + ++
Sbjct: 22347 PTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVT 22406
Query: 1828 KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWT 1887
L YQFR YA N G S + I + P +P V++ T +V+L W+
Sbjct: 22407 GLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPE---VTDVTRSTVSLIWS 22463
Query: 1888 EPESNGGSPITNYIIEFKTVK---GKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
P +GGS + YIIE K V W K S + + + E D FR+ A+N
Sbjct: 22464 APAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKN 22523
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVM 1984
GV + S+S +PP A L+ R+ G + +
Sbjct: 22524 AAGV-ISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTI 22562
Score = 231 bits (565), Expect = 2e-59
Identities = 221/892 (24%), Positives = 366/892 (41%), Gaps = 44/892 (4%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKSVIEDTEKFTLISDVK 1249
VE P + ++ + I+V A + +I L V +W K IE+ + +IS
Sbjct: 19287 VEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN 19346
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV--EVVEFP-PKIVDYEREYRIKRGSDVT 1306
L ++ C D +Y L + T + V +V++ P P E ++
Sbjct: 19347 HTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLS 19406
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
+ D +IV + T + + S + K+ + I+++ N
Sbjct: 19407 WGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKY 19466
Query: 1367 GHADVEMNVTI--LDK---PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
G + +V I LD PSPP I + S+ +CW PE+ G S I Y++E +E
Sbjct: 19467 GVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERRE 19526
Query: 1422 IDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
++ W+ V K + + L+ Y +R YA N +S SET+ + +
Sbjct: 19527 KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFL 19586
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIF-GGVPQPKVTW-YR-----DGK-KLKTAKAT-YE 1530
SP + + + + +F GG P T Y+ D K +++ + T Y
Sbjct: 19587 PSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYT 19646
Query: 1531 NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDE 1589
K A + + +++P+ I +E K K G
Sbjct: 19647 ISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGAS 19706
Query: 1590 WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
+ +T G P P V+W K L + Y TT +TS + I+ R+ S KYT+ N
Sbjct: 19707 FTMTVPFRGRPVPNVLWSKPDTDLRT-RAYVDTTDSRTS-LTIENANRNDSGKYTLTIQN 19764
Query: 1650 TAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
+S+ + +KV D P P + ++++++ES + W P +DGG + Y IEK E
Sbjct: 19765 VLSAASLTLVVKVLDTPGPPTN-ITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREAS 19823
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
W+ V + + +Y + L E Y FRV +N G E++ V T P
Sbjct: 19824 KKAWVSVTNNCNRL-SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE 19882
Query: 1770 XXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQK 1828
I +SV +TW E +GGS I+ Y VE ++G+K W +
Sbjct: 19883 KLGVTS---ISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSG 19939
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS-QPRNFVVSESTSRS-VTLKW 1886
L N+ Y FR++A N+ G S P + I + L PP +NF R+ LK
Sbjct: 19940 LRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKV 19999
Query: 1887 TEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEK---DEIIFRISAE 1943
P S G P+ + V K+ + T E+ N+KE D + I+A
Sbjct: 20000 DIPIS--GKPLPKVTLSRDGVPLKATMRFNT--EITAENLTINLKESVTADAGRYEITAA 20055
Query: 1944 NTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI 2003
N+ G + V L++ P PPT P+ I + V W P++DGG+ + Y +
Sbjct: 20056 NSSGTT-KAFINIVVLDR----PGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYIL 20110
Query: 2004 AIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
R+ + +W EV T+ + L+ Y RI A N G+S+ ++S
Sbjct: 20111 LKRETSTAVWTEVSATVARTM-MKVMKLTTGEEYQFRIKAENRFGISDHIDS 20161
Score = 230 bits (563), Expect = 4e-59
Identities = 211/770 (27%), Positives = 325/770 (42%), Gaps = 50/770 (6%)
Query: 1216 LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
L V++P T VTW+K ++ T + S L I+ +D Y L +
Sbjct: 15668 LKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTN 15727
Query: 1273 A--KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+ ++ L V V++ P + + S +TL P+ + +N+ I++K
Sbjct: 15728 SAGEAIETLNVIVLDKPGPPTGPVKMDEVTADS-ITLS---WGPPKYDGGSSINNYIVEK 15783
Query: 1331 ---CKHTKPSIDSKSASLTIKKVENTDAGIYKLRL--ENNCGHAD-VEMNVTILDKP--- 1381
T + + A TIK Y+ R+ EN G + + T+ P
Sbjct: 15784 RDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKV 15843
Query: 1382 -SPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQT 1438
PPG P + S+ + W+EP + G S +I Y +E +E ++ W+ + I +T+
Sbjct: 15844 PGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKF 15903
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
L+ Y FR A N V I S+ +E Y + P +P I T +
Sbjct: 15904 KTTGLEEGVEYEFRVSAENIVGIGKPSKVSECY--VARDPCDPPG--RPEAIIVTRNSVT 15959
Query: 1499 IELT--CIFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXY--KC 1550
++ GG K+T Y KK + KA++ N Y +
Sbjct: 15960 LQWKKPTYDGG---SKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRV 16016
Query: 1551 IAFNDHGEV-ETSCVVG-IQQKPVITISNEDIKQKHK------VGDEWLVTAVIEGIPPP 1602
IA N G E S G I + + + K+K G+ + V A I G P P
Sbjct: 16017 IARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP 16076
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ W K +L N I + + + + +K+ R S Y ++A N AG SV V +KV
Sbjct: 16077 TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKV 16136
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
D+P PEGPV++ ++ E T+ WKPPL DGG ++ Y +E+ E W V D +
Sbjct: 16137 LDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVW-TVVDANVQ 16195
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+ + KL E EY FR++A N G E LESEP+V K VP + +
Sbjct: 16196 TLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPD-APKAPEVTTVTKD 16254
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXARIQKLSI--NTTYQFRI 1839
S+ + W +GGS I+ Y +E + +EG +W R++ + N Y+FR+
Sbjct: 16255 SMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRV 16314
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N G S P + P P N V + T SV L W++P +GG I
Sbjct: 16315 SAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQG 16374
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHC-IENIKEKDEIIFRISAENTVGV 1948
YI+E V WT G + +E + EK E FRI A N GV
Sbjct: 16375 YIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGV 16424
Score = 230 bits (563), Expect = 4e-59
Identities = 170/673 (25%), Positives = 288/673 (42%), Gaps = 33/673 (4%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
++ G + + ++ P P W + ++ L+I + DAG Y
Sbjct: 17539 VRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNY--TQLSIDNCDRNDAGKY 17596
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE 1418
L+LEN+ G + V +LD P PP + E+ S + W+ P G + + YV++
Sbjct: 17597 ILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID 17656
Query: 1419 YQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKET 1477
+E + +V + +KT ++NL + Y FR A NE + ET + K +
Sbjct: 17657 KRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPP 17716
Query: 1478 ----KIQSPTVEKPLKNITTEPNEDIELTCIFGGVP--QPKVTWYRDGKKLKTAKATYEN 1531
K+ V + ++ E E + + G V QPK T K A++ N
Sbjct: 17717 SPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGT----EKWSIVAESKVCN 17772
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-----KV 1586
++ A+N+ G+ + V+G+ +K +
Sbjct: 17773 ---AVVTGLSSGQEYQFRVKAYNEKGKSDPR-VLGVPVIAKDLTIQPSLKLPFNTYSIQA 17828
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G++ + + G P P + W K+G L+ N+ ++V+ IKE + KYT+
Sbjct: 17829 GEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVT 17888
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKH 1706
A+N+AGT++ +++ V +KP P GPV E+S + V I W+PP GG +++ Y +EK
Sbjct: 17889 ATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKR 17948
Query: 1707 EPDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALD 1765
+ W V A V R T I KL EY FR+ A+N G S L+S+ ++++
Sbjct: 17949 DTTTTTWHMVSATVAR--TTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFK 18006
Query: 1766 VPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXA 1824
P I + + + W +GG+ II Y +E K++ W
Sbjct: 18007 EPG-PPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDT 18065
Query: 1825 RIQKLSIN--TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSV 1882
+ + ++ Y+F++ A N +G P + PP +P V+ T +V
Sbjct: 18066 KFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVI---TRNNV 18122
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TLKW +P +GGS IT YI+E K + W K E + + E FR+ A
Sbjct: 18123 TLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIA 18182
Query: 1943 ENTVG-VSLPTES 1954
N G S P++S
Sbjct: 18183 RNAAGNFSEPSDS 18195
Score = 229 bits (561), Expect = 6e-59
Identities = 207/857 (24%), Positives = 348/857 (40%), Gaps = 45/857 (5%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVV 1284
VTW+K IE + + +L +R T D + YT +A + K +KV+V
Sbjct: 21493 VTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQ 21552
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
+ P K+V R I G +TL D P +I+ + + ++
Sbjct: 21553 DTPGKVVGPIRFTNIT-GEKMTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 21611
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCG-----HADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
S T K+ N + +++ N G +D + P PG P I +SI
Sbjct: 21612 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 21671
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKTQTSIQNLKTNSSYRFRAY 1454
+ W PE+ G S I Y++E +E +T W+ V + I++T+ + L + Y F
Sbjct: 21672 TLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVM 21731
Query: 1455 AVNEVDISDASETTEYYKVIKETKIQSP-TVEKPLKNITTEPNEDIELTCIFGGVP---- 1509
A N + AS + K + P TV K T + + GG+
Sbjct: 21732 AENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGY 21791
Query: 1510 --QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVG- 1566
+ D K+ A+A + R ++ A N G+ ++ V G
Sbjct: 21792 IIEMCKADLGDWHKVN-AEACVKTRYTVTDLQAGEEYK--FRVSAINGAGKGDSCEVTGT 21848
Query: 1567 IQQKPVITISNEDI----KQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
I+ +T DI KQ H V G + +G P P +W K + L +
Sbjct: 21849 IKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLS--LRAD 21906
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
I T + S + ++ R+ + KYT+ N +G+ S+ T+KV D P P GP+ ++++R
Sbjct: 21907 IHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPP-GPITFKDVTR 21965
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S T+ W PL DGG + Y +EK E W +V + + + L E Y FR
Sbjct: 21966 GSATLMWDAPLLDGGARIHHYVVEKREASRRSW-QVISEKCTRQIFKVNDLAEGVPYYFR 22024
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
V A N G E E ++ T P S + W + +GGS I
Sbjct: 22025 VSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDT---SKSSAVLAWLKPDHDGGSRIT 22081
Query: 1801 DYKVEIKQEGKK-WKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
Y +E++Q+G W +++L T Y+FR+ A+N+ G S P + + I
Sbjct: 22082 GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVII 22141
Query: 1860 GKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTV 1918
+ P+ + ++ + +T G P + + ++ K ++ +T
Sbjct: 22142 KEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITT 22201
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMV 1978
+++ D + ++ ENT GV T S +V + P P T P+E+ V
Sbjct: 22202 TKDRTTLTVKDSMRGDSGRYFLTLENTAGVK--TFSVTVVVIGR---PGPVTGPIEVSSV 22256
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
+ + SWG P+ GG + Y + R+ T W V V + + L++ Y
Sbjct: 22257 SAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNS-SVKRTQIKVTHLTKYMEYS 22315
Query: 2039 IRIYARNEIGLSEPLES 2055
R+ + N G+S+PLES
Sbjct: 22316 FRVSSENRFGVSKPLES 22332
Score = 227 bits (555), Expect = 3e-58
Identities = 209/895 (23%), Positives = 364/895 (40%), Gaps = 51/895 (5%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKSVIEDTEKFTLISDVKKRT 1252
P+I+ + + I VPA L + I +W+ S + ++E+ T+ + K
Sbjct: 23239 PTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAK 23298
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQ 1312
L IR+ T D EYT L + TT ++V+ K +I ++ + ++
Sbjct: 23299 LTIRETTIRDTGEYTLELKNVTGTTSETIKVIILD-KPGPPTGPIKIDEIDATSITISWE 23357
Query: 1313 AFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT---IKKVENTDAGIYKLRLE--NNCG 1367
P+ + ++ ++++ +P S S+T K T+ Y R+ N G
Sbjct: 23358 P-PELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFG 23416
Query: 1368 HADVEMNVTI-----LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI 1422
+ I + P PP I ++ + + W PE+ G S + Y+VE +E+
Sbjct: 23417 IGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEV 23476
Query: 1423 DTTEWISVKNITKTQTSIQN--LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ 1480
W+ V + T T ++ L Y R A+N S ++ ++ I
Sbjct: 23477 RADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSK--PIVAMDPIA 23534
Query: 1481 SP-TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR------DGKKLKTAKATYENRX 1533
P + P TT + + + + KVT Y D + T
Sbjct: 23535 PPGKPQNPRVTDTTRTSVSLAWS-VPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIR 23593
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVG-IQQKPVITISNEDIKQKH------KV 1586
++ +A N G E + V G ++ ++ + ++ +++ +
Sbjct: 23594 EYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQ 23653
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G +T I+G P P W K G + K I T E + + IKE R S Y +
Sbjct: 23654 GGVIRLTIPIKGKPFPICKWTKEGQDIS--KRAMIATSETHTELVIKEADRGDSGTYDLV 23711
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKH 1706
N G +V + ++V P+ PEGP+ +I SV + W+PP DDGG ++ Y +E+
Sbjct: 23712 LENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERR 23771
Query: 1707 EPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTALD 1765
E W + R + ++ L EN EY FRV A+N G S+ L+S EP+ KT L+
Sbjct: 23772 EVPKAAWYTIDSRVRGT-SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLN 23830
Query: 1766 VPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKW--KXXXXXXXX 1822
P + SV ++W + +GGS + Y +E K+ KW
Sbjct: 23831 PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTT 23890
Query: 1823 XARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSV 1882
+ L + YQFRI A+N++G S + + + PSQP + + SV
Sbjct: 23891 MYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSV 23950
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TL+W +PE +GG I Y +E++ +W K + I + E E FR+ A
Sbjct: 23951 TLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFA 24010
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
EN G+S P + ++ ++ T P E++ V + + G A L
Sbjct: 24011 ENETGLSRPRRT-AMSIKTKLTSGEAPGIRKEMKDVTTKL-----------GEAAQLSCQ 24058
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
I R + W GK + + K+ + HT + + + G+ + ++E
Sbjct: 24059 IVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNE 24113
Score = 227 bits (554), Expect = 4e-58
Identities = 206/781 (26%), Positives = 325/781 (41%), Gaps = 48/781 (6%)
Query: 1207 LVPANTDAYLTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
LV A + VEIP VTW K +++ T++ + L I +C D
Sbjct: 14577 LVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDS 14636
Query: 1264 CEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
Y L A++ +V+ + IK + V + P ND +
Sbjct: 14637 GPYP---LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14693
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIK---KVENTDAGI---YKLRLENNCGHADVEMNVTI 1377
S + + + T + + A+ I+ K G+ ++++ +N G + I
Sbjct: 14694 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 14753
Query: 1378 LDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN 1432
+ P PPG P + + S+ I W EP + G S I+ Y VE +E + W +V
Sbjct: 14754 VANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSK 14813
Query: 1433 ITKTQTSIQN--LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN 1490
++ L +Y FR A N S S+ +E ++ I P PL N
Sbjct: 14814 ALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSE--PMLALDPIDPPGKPVPL-N 14870
Query: 1491 ITTEP-NEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXXXXXXXXXXXXX 1545
IT GG K+T Y RD + KA + N
Sbjct: 14871 ITRHTVTLKWAKPEYTGGF---KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTED 14927
Query: 1546 XXY--KCIAFNDHGEV----ETSCVVGIQQKPVITISNEDIKQKH----KVGDEWLVTAV 1595
Y + IA N G + E S + + D+K K K G+ + + A
Sbjct: 14928 AAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEAD 14987
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ G PPP + W K+G +LE + I + ++ + K+ R S YT+ A+N G +
Sbjct: 14988 VSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAK 15047
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
+KV D+P PEGP+ + E++ E + W PPLDDGG ++ Y ++K E W
Sbjct: 15048 HIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTN 15107
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXX 1775
VA + V + KL + EY+FRV+A N G E LESEP++ P
Sbjct: 15108 VAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYG-PPDPPKNPE 15165
Query: 1776 XXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQE-GKKWKXXXXXXXXXAR--IQKLSIN 1832
I +S+ + W + +GGS II+Y VE + + G++W R + L+
Sbjct: 15166 VTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEG 15225
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESN 1892
Y+FRI A N G S P + T+ P P N V +++ S+++ W +P +
Sbjct: 15226 HEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYD 15285
Query: 1893 GGSPITNYIIEFKTVKGKSWTKIVT--VGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
GGS IT Y++E + W +IVT G + I + E E RI A N+ G+
Sbjct: 15286 GGSEITGYMVEIALPEEDEW-QIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 15344
Query: 1951 P 1951
P
Sbjct: 15345 P 15345
Score = 224 bits (547), Expect = 3e-57
Identities = 238/963 (24%), Positives = 395/963 (41%), Gaps = 77/963 (7%)
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL 1200
+D E+QF+ ++ ++G + + ++ + + S VG C + P + ++
Sbjct: 9572 RDVEELQFT--VEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDC------QRPDMPPSI 9623
Query: 1201 RLPEFILVPANTDAYLTVEIPDETLD-VTWYK--------KKSVIEDTEKFTLISDVKKR 1251
L EF+ V T+ + +I +TW+K K+ V+ DT L+ D
Sbjct: 9624 DLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD-DTC 9682
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
TL+I + D YT ++ T ++++ V+ P V ++ +TL
Sbjct: 9683 TLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVG-PIKFESVSADQMTL-- 9739
Query: 1310 DYQAFPQPND--EWIVNSKIIKKCKHTKP----SIDSKSASLTIKKVENTDAGIYKLRLE 1363
FP +D I N I K+ + K S + K + TI K+ ++++ +
Sbjct: 9740 --SWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQ 9797
Query: 1364 NNCG-----HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE 1418
N G ++ E + P P KP + + +S+ + W+EPE G S + Y +E
Sbjct: 9798 NKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLE 9857
Query: 1419 YQEIDTTEWISV-KNITKTQT-----SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
++ + W V ++ K T + L S Y+FR YA+N + AS ++
Sbjct: 9858 MKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSD--P 9915
Query: 1473 VIKETKIQSPTVEKPLKNITTEPNEDIELTCIF---GGVPQPKVTWYRDGKKLKTAKATY 1529
I P P T+ + D+E + G + Y++ K + K
Sbjct: 9916 ATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKD 9975
Query: 1530 ENRXXXXXXXXXXXXXXXYK----CIAFNDHGEV-ETSCVVGIQQKPVITISNEDIKQKH 1584
+ YK + GE E + V+ ++ + V D +
Sbjct: 9976 KEVRGTKLVVTGLKEGAFYKFRVSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRD 10035
Query: 1585 KV----GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHS 1640
++ G + A + G PPP V W N L +E I T +S + IK +RSH
Sbjct: 10036 RIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLP--QEATIETTAISSSMVIKNCQRSHQ 10093
Query: 1641 SKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTK 1700
Y++ A N AG + + V D P P + ++ ES + W P DDGG +T
Sbjct: 10094 GVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITN 10153
Query: 1701 YAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPI 1758
Y IEK E D W V V R T +Q L + Y FR+ A+N +G +E SE +
Sbjct: 10154 YVIEKRESDRRAWTPVTYTVTRQNAT--VQGLIQGKAYFFRIAAENSIGMGPFVETSEAL 10211
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXX 1818
VI+ + VP N +V +TW P + +GGS II+Y +E + G +
Sbjct: 10212 VIREPITVPERPEDLEVKEVTKN-TVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVT 10270
Query: 1819 XXXXXAR---IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVS 1875
+R ++ L TY++R+ A N +G P IT L PP+ +F
Sbjct: 10271 NDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDK 10330
Query: 1876 ESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEK-- 1933
+ T S P ++ + V T I T ++ +E IK K
Sbjct: 10331 LTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATL---ALEKIKAKRS 10387
Query: 1934 DEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
D + + EN+ G S Q +++ P PP P+ V + ++ SW P D
Sbjct: 10388 DSGKYCVVVENSTG-SRKGFCQVNVVDR----PGPPVGPVSFDEVTKDYMVISWKPPLDD 10442
Query: 1994 GGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
GG+ + Y I ++V K +WM V T + L E Y+ RI+A N G+S+PL
Sbjct: 10443 GGSKITNYIIEKKEVGKDVWMPVTSASAKT-TCKVSKLLEGKDYIFRIHAENLYGISDPL 10501
Query: 2054 ESD 2056
SD
Sbjct: 10502 VSD 10504
Score = 223 bits (545), Expect = 5e-57
Identities = 192/796 (24%), Positives = 337/796 (42%), Gaps = 44/796 (5%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSV-IEDTEKFTLISDVK 1249
+E P I+ + V A ++ + + I + L + V ++ T +F +
Sbjct: 19974 LEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAE 20033
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
T+ +++ D Y ++ TTK + +V + I ++ ++ +
Sbjct: 20034 NLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLD-RPGPPTGPVVISDITEESVTL 20092
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSID-SKSASLTIKKVENTDAGI---YKLRLENN 1365
++ + N ++K+ T + S + + T+ KV G ++++ EN
Sbjct: 20093 KWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENR 20152
Query: 1366 CGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
G +D + + K P PP P + + SI + W EP + G S ++ Y +E +
Sbjct: 20153 FGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMK 20212
Query: 1421 EIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK 1478
+ ++ W I T + + Y FR YA N + S +E V+
Sbjct: 20213 DRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSE--PVLAIDA 20270
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXX 1534
+ P + + + GG K+T Y RD + KA++ N
Sbjct: 20271 CEPPRNVRITDISKNSVSLSWQQPAFDGG---SKITGYIVERRDLPDGRWTKASFTNVTE 20327
Query: 1535 XXXXXXXXXXXXXYKCIAF--NDHGEVET-SCVVG------IQQKPVITISNEDIKQ-KH 1584
Y+ F N G + S VVG PVI + E + K+
Sbjct: 20328 TQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKY 20387
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+ G + A I G P P + WYK+ +L+ + + + I IK+ R +S Y
Sbjct: 20388 RAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYE 20447
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
++ N G++S + +++ DKP P GP+ + ++ E +T+ W+PP DDGG ++T Y +E
Sbjct: 20448 LKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVE 20507
Query: 1705 KHEPDNNRWIKVAD-VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTA 1763
K E W V++ ++ + T K+ + EY+FRV A N G E LES+ +V K A
Sbjct: 20508 KRETSRVVWSMVSEHLEECIIT--TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNA 20565
Query: 1764 LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK--WKXXXXXXX 1821
P I S+ + W +GGS I Y +E K++ K W
Sbjct: 20566 FVTPG-PPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLE-KRDKKSLGWFKVLKETI 20623
Query: 1822 XXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKI-TIGKTLTPPSQPRNFVVSEST 1878
R + L+ N+ YQ+R+ A N G P++ + + PP P +++ST
Sbjct: 20624 RDTRQKVTGLTENSDYQYRVCAVNAAGQG-PFSEPSEFYKAADPIDPPGPPAKIRIADST 20682
Query: 1879 SRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG-SVHEHCIENIKEKDEII 1937
S+TL W++P +GGS +T Y++E + + + WT + T G E+ + N+K
Sbjct: 20683 KSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYY 20742
Query: 1938 FRISAENTVGVSLPTE 1953
FR+SA N G P E
Sbjct: 20743 FRVSAVNCAGQGEPIE 20758
Score = 223 bits (544), Expect = 7e-57
Identities = 198/807 (24%), Positives = 354/807 (43%), Gaps = 56/807 (6%)
Query: 1191 VEEPSINFTLRLPEFI--LVPANTDAYLTVEIPDE---TLDVTWYKKKSVIEDTEKFTLI 1245
++EP I T L L+ + T+++P VTW ++ +++T++ ++
Sbjct: 22141 IKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSIT 22200
Query: 1246 SDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYEREYRIKRGSD 1304
+ + TL ++ D Y L + V VV P V E + S
Sbjct: 22201 TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIE--VSSVSA 22258
Query: 1305 VTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP--SIDSKSASLTIKKVENTDAGIYKLRL 1362
+ ++ + I N + K+ T ++S IK T Y R+
Sbjct: 22259 ESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRV 22318
Query: 1363 --ENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
EN G + + I+ + PS P +P + + +++++I W+EP + G S II Y
Sbjct: 22319 SSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGY 22378
Query: 1416 VVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
VE +E +T W+ + + + + L Y+FR YA+N +S ASE + +
Sbjct: 22379 WVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASR--PI 22436
Query: 1474 IKETKIQSP-------TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK 1526
+ + + +P + I + P D + + + V+ DG+ LK
Sbjct: 22437 MAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLK-CN 22495
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV----ETSCVVGIQQKPVITISNEDIKQ 1582
T + ++ +A N G + E++ V + + + D +
Sbjct: 22496 YTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARL 22555
Query: 1583 KH-----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKR 1637
+ G + ++ A + G P P++IW K +L+ ++ ++ K + IK R
Sbjct: 22556 HGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDR 22615
Query: 1638 SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLE 1697
S S KYT+ N +GT +V V +KV D P P G + + +++E T+ W P +DGG E
Sbjct: 22616 SDSGKYTLTVKNASGTKAVSVMVKVLDSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAE 22674
Query: 1698 LTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEP 1757
+T Y +E+ E W+ + + + +Y + +L +N EY+FRV A N G +ESEP
Sbjct: 22675 ITHYIVERRETSRLNWV-IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEP 22733
Query: 1758 IVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK--KW-- 1813
IV + + +PS E + I W E +GG+ I +Y V+ K+E K +W
Sbjct: 22734 IVARNSFTIPSPPGIPEEVGT-GKEHIIIQWTKPESDGGNEISNYLVD-KREKKSLRWTR 22791
Query: 1814 -KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK---TLTPPSQP 1869
++ L YQFR+ A N G S P + + I+ + T PPS P
Sbjct: 22792 VNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAP 22851
Query: 1870 RNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVH--EHCI 1927
R V ++T S++L WT+P +GG+ I Y++E + W ++ T ++ E +
Sbjct: 22852 R---VVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHT-NATIRNTEFTV 22907
Query: 1928 ENIKEKDEIIFRISAENTVGVSLPTES 1954
++K + FR++A N G+S +ES
Sbjct: 22908 PDLKMGQKYSFRVAAVNVKGMSEYSES 22934
Score = 221 bits (540), Expect = 2e-56
Identities = 185/703 (26%), Positives = 304/703 (43%), Gaps = 40/703 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV----KNITK 1435
KPSPP P ++ +S+++ W P + G S I+ Y+VEYQ++ EW ++ +
Sbjct: 10615 KPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPE 10674
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
T+ + L+ +Y+FR AVN SD + E V+ + +++ P + N+ E
Sbjct: 10675 TKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE--PVLVKDRLEPPELILDA-NMAREQ 10731
Query: 1496 N----EDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXXXXY 1548
+ + + L+ I GVP PKVTW ++ + T KA + Y
Sbjct: 10732 HIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPT-KARIDVTPVGSKLEIRNAAHEDGGIY 10790
Query: 1549 KCIAFNDHGEVETSCVVGIQQKPVITISNEDIK-QKHKVGDEWLVTAVIEGIPPPEVIWY 1607
N G S V + KP E + +K W G +
Sbjct: 10791 SLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVE 10850
Query: 1608 KNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT---LKVYD 1664
+ + T+K+K+ K L + + + A N G T +K D
Sbjct: 10851 RRDVASAQWSPLSATSKKKSHFA--KHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALD 10908
Query: 1665 KPSKPEGP---VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
P P GP + ++ + V++ W P DGG +T Y +E E WIK V
Sbjct: 10909 -PLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVT- 10966
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDN 1781
++E + L + Y FRV A+N VG + PI + L PS +
Sbjct: 10967 NLECV-VTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVV 11025
Query: 1782 ESVYITWFPSEKNGGS-PIIDYKV---EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQF 1837
++ FP+ G P + EIK + + + I+ T ++
Sbjct: 11026 KAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSVLTIKNCLRRDTGEY 11084
Query: 1838 RIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPI 1897
+I N G+ T +T+ PP+ P N + + T +T+ W P+ +GGSP+
Sbjct: 11085 QITVSNAAGSK---TVAVHLTVLDVPGPPTGPINIL--DVTPEHMTISWQPPKDDGGSPV 11139
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
NYI+E + + +W +V+ G S + I ++++ E +FR+ AEN +GV P +S
Sbjct: 11140 INYIVEKQDTRKDTWG-VVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPT 11198
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
+ + PSPP P+ + + N SW P+ DGG+P+ GY + R+VT W+ V
Sbjct: 11199 VAKHKFSPPSPPGKPV-VTDITENAATVSWTLPKSDGGSPITGYYMERREVTGK-WVRVN 11256
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
K + LKF + L E +TY R++A N GLS+P S +P K
Sbjct: 11257 KTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIK 11299
Score = 220 bits (537), Expect = 5e-56
Identities = 207/803 (25%), Positives = 340/803 (42%), Gaps = 53/803 (6%)
Query: 1202 LPEFI-LVPANTDAYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
LP+ L N++ L + I + V+W K + + + ++ S TLI+ C
Sbjct: 13490 LPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQ 13549
Query: 1260 EDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
+ D +YT L + T + + + V P I ++ +TL A P+ +
Sbjct: 13550 KSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLK---WAPPKDD 13606
Query: 1319 DEWIVNSKIIKK--CKHTKPSIDSKSASLTIKKVENTDAGI---YKLRLENNCGHADVEM 1373
+ + I++K + K + + T +V G+ +++ EN G +
Sbjct: 13607 GGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLK 13666
Query: 1374 NVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWI 1428
+ I+ D P P PNI+++ S+++ W +P+ TG S I Y +E++E ++ W
Sbjct: 13667 SEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLW- 13725
Query: 1429 SVKNITKTQTSIQNLKTNS-----SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT 1483
K KT +++ K Y FR A+N + S +E V+ I P
Sbjct: 13726 --KRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSE--PVVALDPIDPPG 13781
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXXXXXXX 1539
+ + NIT I + G K+T Y RD KA + N
Sbjct: 13782 KPEVI-NITRNSVTLIWTEPKYDG--GHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTV 13838
Query: 1540 XXXXXXXXY--KCIAFNDHGEV-------ETSCVVGIQQKPVITISNEDIKQ--KHKVGD 1588
Y + A N G + ET + P I + + IK K GD
Sbjct: 13839 TDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVL-DPTIKDGLTIKAGD 13897
Query: 1589 EWLVTAV-IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
++ A+ I G P P+ W K G + IT+ +S++ IK R + +YTI A
Sbjct: 13898 TIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITA 13957
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
+N GT V + V D P P GPV + +S E T+ W PPL+DGG + Y +EK E
Sbjct: 13958 TNPFGTKVEHVKVTVLDVPGPP-GPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRE 14016
Query: 1708 PDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP 1767
W V++ D + KL + EY+FRV A N G E ++SEP+ + P
Sbjct: 14017 TSRLLWTVVSE-DIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPP 14075
Query: 1768 SXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXXXXXXXXAR- 1825
N + ++W +GGS I Y VE ++ + +W R
Sbjct: 14076 GPPEKPEVSNVTKNTAT-VSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRC 14134
Query: 1826 -IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTL 1884
+ L +TY+FR+ A N G P + D + + PP P N V+++T +S +L
Sbjct: 14135 KVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASL 14194
Query: 1885 KWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT-VGGSVHEHCIENIKEKDEIIFRISAE 1943
W +P +GG IT Y++E + V ++W K T + + + +++ K++ FRISA
Sbjct: 14195 AWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAI 14254
Query: 1944 NTVGVSLPTESQSVRLEKHATVP 1966
N GV P V + + P
Sbjct: 14255 NDAGVGEPAVIPDVEIVEREMAP 14277
Score = 217 bits (531), Expect = 3e-55
Identities = 198/748 (26%), Positives = 332/748 (44%), Gaps = 48/748 (6%)
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD--VEMNVTILDK---PSPPGKPNILE 1391
S +K+ K +E D I+++ EN G +D V ++ D+ P P +P + E
Sbjct: 10467 SASAKTTCKVSKLLEGKDY-IFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTE 10525
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNIT---KTQTSIQNLKTNSS 1448
+ S + W++P + G I Y++E +E + W V T+ + +L
Sbjct: 10526 VTKDSALVTWNKPHD-GGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQ 10584
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI---- 1504
Y FR A NE+ I D S ++ V + I P+ + I T N ++LT
Sbjct: 10585 YEFRVSAENEIGIGDPSPPSK--PVFAKDPIAKPSPPVNPEAIDTTCNS-VDLTWQPPRH 10641
Query: 1505 FGG--VPQPKVTWYRDG-KKLKTAKATYENRXXXXXXXXXXXXXXXYK--CIAFNDHGEV 1559
GG + V + + G ++ + A T E+ YK +A N GE
Sbjct: 10642 DGGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGES 10701
Query: 1560 ETSCV---VGIQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
+ + V V ++ + P + + +++H KVGD ++A+I+G+P P+V W K
Sbjct: 10702 DPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRD 10761
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
++T S + I+ Y++ N AG+ +V V + V DKP P
Sbjct: 10762 APTKARIDVT--PVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPR-D 10818
Query: 1673 VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLN 1732
+ + EI ++S + WK PLDDGG +T Y +E+ + + +W ++ + +++ + LN
Sbjct: 10819 LEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKK-KSHFAKHLN 10877
Query: 1733 ENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV--PSXXXXXXXXXXIDNESVYITWFP 1790
E +Y+FRV A+N G +E+ P IK ALD P +D V + W
Sbjct: 10878 EGNQYLFRVAAENQYGRGPFVET-PKPIK-ALDPLHPPGPPKDLHHVDVDKTEVSLVWNK 10935
Query: 1791 SEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSL 1849
+++GGSPI Y VE ++EG + W + L TY+FR+ A N +G L
Sbjct: 10936 PDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGL 10995
Query: 1850 PYTSDDKITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESNGGSPITNYIIEFKTV 1907
P T+ I + L PPS + + E T+++ P + + +
Sbjct: 10996 PDTT-IPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI 11054
Query: 1908 KGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPS 1967
K + T S I+N +D ++I+ N G +++ +V L VP
Sbjct: 11055 KTDEHYTVETDNFS-SVLTIKNCLRRDTGEYQITVSNAAG----SKTVAVHLTV-LDVPG 11108
Query: 1968 PPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFN 2027
PPT P+ I V + SW P+ DGG+P++ Y + +D K W V T K
Sbjct: 11109 PPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT-KLK 11167
Query: 2028 IRDLSENHTYMIRIYARNEIGLSEPLES 2055
I L + Y+ R+ A N+IG+ PL+S
Sbjct: 11168 IPHLQKGCEYVFRVRAENKIGVGPPLDS 11195
Score = 217 bits (531), Expect = 3e-55
Identities = 170/693 (24%), Positives = 291/693 (41%), Gaps = 26/693 (3%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP P +++ SI++ W +P G + I+ YV+E QE DT +W V I T+
Sbjct: 22845 PGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE 22904
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPN 1496
++ +LK Y FR AVN +S+ SE+ + ++ +I + LK +T
Sbjct: 22905 FTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAG 22964
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFN 1554
+ L G P P +TW + G L + T E+ Y A N
Sbjct: 22965 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAEN 23024
Query: 1555 DHGEVETSCVVGIQQKP--VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
G+ + +V + P ++ +++ + V W + + G P I K
Sbjct: 23025 QSGKKSATVLVKVYDTPGPCPSVKVKEVS-RDSVTITWEIPTIDGGAPVNNYIVEKREAA 23083
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+ K +TTK ++ RI L + + N G T P P
Sbjct: 23084 MRAFK--TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVP 23141
Query: 1673 VIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQK 1730
+ ++++ +VT+ W+ PL DGG LT Y +E + RW+KV + V + +
Sbjct: 23142 AKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTS 23201
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV-PSXXXXXXXXXXIDNESVYITWF 1789
LNE +Y+FR+ AQN G SE E+ V L V P+ I +
Sbjct: 23202 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVEL 23261
Query: 1790 PSEKNGGSPIID---YKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
G P + +E ++ I++ +I T ++ + +N G
Sbjct: 23262 VIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTG 23321
Query: 1847 TSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT 1906
T+ + K+ I PP+ P + E + S+T+ W PE +GG+P++ Y++E +
Sbjct: 23322 TT---SETIKVIILDKPGPPTGP--IKIDEIDATSITISWEPPELDGGAPLSGYVVEQRD 23376
Query: 1907 VKGKSWTKIV-TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATV 1965
W + +V S + + E +E +FR++A N G+ +S+ + +
Sbjct: 23377 AHRPGWLPVSESVTRSTFK--FTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRI 23434
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP L+I V + + +W PE DGG+ + GY + ++V W+ V KV V +
Sbjct: 23435 PGPPET-LQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTR 23493
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ L+E Y R+ A N G +P +P
Sbjct: 23494 YRSTGLTEGLEYEHRVTAINARGSGKPSRPSKP 23526
Score = 217 bits (530), Expect = 4e-55
Identities = 236/1040 (22%), Positives = 413/1040 (39%), Gaps = 74/1040 (7%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
LPP+I+ Q + G K E + K +W K E+ S+H+ + L
Sbjct: 12401 LPPKILMPEQIT-IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSIL 12459
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAY-LTVEIP 1221
I D D+G YS NS T ++ ++ P F + + DA L+ IP
Sbjct: 12460 IIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIP 12519
Query: 1222 --DETLDVTWY-KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD----AK 1274
D ++T Y +K + + T ++ V K + + K + + + ++
Sbjct: 12520 LEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISE 12579
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
T K+ V +FP + + R+ + + + V + I+ I +K +++
Sbjct: 12580 PLTSPKM-VAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNS 12638
Query: 1335 KPSIDSKSASLTIKKVENTDAGI-----YKLRLE--NNCGHADVEMN---VTILDKPSPP 1384
+ K+ ++ E AG+ Y R+ N G + VT PP
Sbjct: 12639 LLWV--KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPP 12696
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN----ITKTQTSI 1440
GKP ++++ S++++ W P++ G S II Y VE ++ +W+ I + + +
Sbjct: 12697 GKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTA 12756
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI-TTEPNEDI 1499
L+ + Y+FRA A V+IS SE ++ ++ E + +K++ T + ++
Sbjct: 12757 TGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNV 12816
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFND 1555
L G P P V+W +DG LK A+ A N Y A N
Sbjct: 12817 CLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENS 12876
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G + + + KP S +K D A++ PP E + N + +
Sbjct: 12877 SGSKSATIKLKVLDKPGPPAS---VKINKMYSDR----AMLSWEPPLEDGGSEITNYIVD 12929
Query: 1616 DKEYN------ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYD 1664
+E + ++ + +++L H ++ I A N G + + YD
Sbjct: 12930 KRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYD 12989
Query: 1665 KPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE 1724
P + + PVI I+++ +T+ WKPP DDGG +T Y +EK E W KV
Sbjct: 12990 PPGRCDPPVISN-ITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIER 13048
Query: 1725 TYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
T L E EY FRV A N G + ++ P SV
Sbjct: 13049 TLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPAPPAFPKVYDTTRSSV 13108
Query: 1785 YITWFPSEKNGGSPIIDYKVEIKQ-EGKKW---KXXXXXXXXXARIQKLSINTTYQFRIY 1840
++W +GGSPII Y VE+K+ + W + L +T YQFR+Y
Sbjct: 13109 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVY 13168
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSEST--SRSVTLKWTEPESNGGSPIT 1898
A N+IG S P DK L PP + + ++ VT++ P P
Sbjct: 13169 AVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKI 13228
Query: 1899 NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
+ ++ + I + C EN+ + D + ++ EN+ G + +
Sbjct: 13229 TWSKPNVNLRDRIGLDIKSTDFDTFLRC-ENVNKYDAGKYILTLENSCG-----KKEYTI 13282
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
+ K P PP + ++ + + +W P DGG+P++ Y + RD + W V
Sbjct: 13283 VVKVLDTPGPPVN-VTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTV-T 13340
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTE 2078
+ + F + +L E +Y R++A NE G+ +P E+ + K A + PG +
Sbjct: 13341 TECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVK--------ASQTPGPVVD 13392
Query: 2079 VXXXXXXXXXXXXXWLREHN 2098
+ W + H+
Sbjct: 13393 LKVRSVSKSSCSIGWKKPHS 13412
Score = 215 bits (525), Expect = 1e-54
Identities = 135/442 (30%), Positives = 209/442 (47%), Gaps = 13/442 (2%)
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYDKPSKPEGPVIMREISR 1680
K + R+K L ++ + A N AG S+ + +K P P G ++++ +
Sbjct: 7441 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 7500
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
SV + W P DGG ++ Y IE + + W++VA+ + + + L E EY FR
Sbjct: 7501 TSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQ-HLLPGLMEGQEYSFR 7559
Query: 1741 VIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
V A N G SE E S+P++ + L PS N + + W EK+GGSPI
Sbjct: 7560 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKN-TADLKWTVPEKDGGSPI 7618
Query: 1800 IDYKVEIKQEGKK-WKXXXXXXXXX-ARIQKLSINTTYQFRIYARNEIGTSLPYTS-DDK 1856
+Y VE + +K W+ + L+ + Y FR+ A N IG S YT +D
Sbjct: 7619 TNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQS-DYTEIEDS 7677
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
+ T T P P V + T R V LKW P+++GG PI Y+IE K G W K
Sbjct: 7678 VLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAG 7737
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIR 1976
G + ++ E E+ F++ AEN GV P+E + + T P P L +
Sbjct: 7738 KTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVT 7797
Query: 1977 MVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRD-LSENH 2035
G + +W PE +GG+P++GY++ + V WM V + LKF + + + +
Sbjct: 7798 DAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 7857
Query: 2036 TYMIRIYARNEIGLSEPLESDE 2057
Y++R+ A N IG+SEP E E
Sbjct: 7858 EYVLRVRAVNAIGVSEPSEISE 7879
Score = 215 bits (525), Expect = 1e-54
Identities = 213/871 (24%), Positives = 352/871 (40%), Gaps = 56/871 (6%)
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVE 1285
+W K I ++ + S L I+ T D EYT + T +KV V++
Sbjct: 13915 SWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD 13974
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
P E + +T + P +I+ + + T S D +S
Sbjct: 13975 VPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRH 14034
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEMN--VTILDK---PSPPGKPNILEIDSSSINIC 1400
K+ + I+++ N+ G + + V ++D+ P PP KP + + ++ +
Sbjct: 14035 VATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVS 14094
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI-SVKN-ITKTQTSIQNLKTNSSYRFRAYAVNE 1458
W P + G S I Y VE +E + W+ ++K ++ + + L+ S+Y FR A N
Sbjct: 14095 WKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENR 14154
Query: 1459 VDISDASETTEYYKVIKETKIQSP--------TVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
I SE ++ + P T +K +P+ D L V
Sbjct: 14155 AGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEH 14214
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV--VGIQ 1568
KV D +K T ++ A ND G E + + V I
Sbjct: 14215 QKVG---DEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIV 14271
Query: 1569 QKPVITISNEDIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
++ + D + + + G + I+G P PEV W K+ L+N NI
Sbjct: 14272 EREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKN--RANIENT 14329
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI-MR--EISRE 1681
E +++ I E R + K+ + N AG S V ++V D P GPV+ +R +I+++
Sbjct: 14330 ESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTP----GPVLNLRPTDITKD 14385
Query: 1682 SVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRV 1741
SVT+ W PL DGG +T Y +EK E + A TY + L+E CEY FRV
Sbjct: 14386 SVTLHWDLPLIDGGSRITNYIVEKREATRKSY-STATTKCHKCTYKVTGLSEGCEYFFRV 14444
Query: 1742 IAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
+A+N G E E+ EP+ A P I +V + W + +GGS I
Sbjct: 14445 MAENEYGIGEPTETTEPVKASEAPSPPDSLNIMD----ITKSTVSLAWPKPKHDGGSKIT 14500
Query: 1801 DYKVEIKQEGK-KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
Y +E +++G +W ++ L+ Y F++ A N G S P S I
Sbjct: 14501 GYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVK 14560
Query: 1860 GKTLTPPSQPRNFVVSESTSRSV-TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV 1918
+T+ P R +++ +K P P + + +K T
Sbjct: 14561 EQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETT 14620
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMV 1978
S + E ++ D + ++A N VG + ++ H +P PPT P++ V
Sbjct: 14621 ATSTILNINECVRS-DSGPYPLTARNIVG----EVGDVITIQVH-DIPGPPTGPIKFDEV 14674
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S+ V SW PE DGG P+ Y + +R T W+E+ + T + L+ Y
Sbjct: 14675 SSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT-TYKATRLTTGLEYQ 14733
Query: 2039 IRIYARNEIGLSEPLES-----DEPFKVIPG 2064
R+ A+N G+ + S + PFKV PG
Sbjct: 14734 FRVKAQNRYGVGPGITSACIVANYPFKV-PG 14763
Score = 213 bits (521), Expect = 4e-54
Identities = 206/899 (22%), Positives = 374/899 (41%), Gaps = 44/899 (4%)
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTL 1244
T I + P I+ L E + A T L I + + WYK ++ +
Sbjct: 20365 TCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCV 20424
Query: 1245 ISDVKKRTLIIRKCTEDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
+ +++I+ + Y L +A ++ ++V++++ P E++
Sbjct: 20425 ENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKPGP-PGGPIEFKTVTA 20483
Query: 1303 SDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKL 1360
+TLL A +IV + + + S + +T K+ + I+++
Sbjct: 20484 EKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRV 20543
Query: 1361 RLENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
R N G + + +++ K P PPG P + +I +S+ + W P G S I Y
Sbjct: 20544 RAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGY 20603
Query: 1416 VVEYQEIDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
+E ++ + W V + I T+ + L NS Y++R AVN SE +E+YK
Sbjct: 20604 FLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKA 20663
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIF--GGVPQPKVTWYRDGKKLK--TAKATY 1529
P + + + T ++ G V R G++ + T
Sbjct: 20664 ADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKG 20723
Query: 1530 ENRXXXXXXXXXXXXXXXY-KCIAFNDHGEVE-TSCVVGIQQKPVITISNEDIKQK---- 1583
E R Y + A N G+ E +Q K ++ D+
Sbjct: 20724 EVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTS 20783
Query: 1584 --HKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
K G++ V +G PPP V W K+ L +D Y+I + +S++ I ++ R+ +
Sbjct: 20784 VIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTG 20843
Query: 1642 KYTIEASNTAG-TSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTK 1700
KY + N G S V++KV D P+ + + ++ +SR +VT+ W PPL DGG +
Sbjct: 20844 KYILTIENGVGEPKSSTVSVKVLDTPAACQ-KLQVKHVSRGTVTLLWDPPLIDGGSPIIN 20902
Query: 1701 YAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIV 1759
Y IEK + W V ++ + L+E + FRV+A+N +G E E +EP+
Sbjct: 20903 YVIEKRDATKRTW-SVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPV- 20960
Query: 1760 IKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXX 1818
A +VP+ SV ++W + +GGS I +Y VE K +G++ W
Sbjct: 20961 --KAAEVPAPIRDLSMKDS-TKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGI 21017
Query: 1819 XXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSEST 1878
+ +L + +FR++A+NE G S P T +TP + ++ T
Sbjct: 21018 SKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVT 21077
Query: 1879 SR-SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEII 1937
R + P P +++ + +K + + + I+N K++
Sbjct: 21078 VRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKI-TLSIKNAKKEHGGK 21136
Query: 1938 FRISAENTV-GVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGA 1996
+ + +N V +++P ++ PS P P+ + ++ V+ SW PE +GG
Sbjct: 21137 YTVILDNAVCRIAVPITVITL------GPPSKPKGPIRFDEIKADSVILSWDVPEDNGGG 21190
Query: 1997 PLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
+ Y+I R+ ++T W V V F + +L ++ Y R+ A N G+S+PL S
Sbjct: 21191 EITCYSIEKRETSQTNWKMVCS-SVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVS 21248
Score = 213 bits (520), Expect = 6e-54
Identities = 228/896 (25%), Positives = 367/896 (40%), Gaps = 72/896 (8%)
Query: 1204 EFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
+ + + A +D L + + + W K ++ EK +L K+ T +I+ C D
Sbjct: 22558 DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSD 22617
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-- 1320
+YT + +A T + V V K++D S VT A+ P ++
Sbjct: 22618 SGKYTLTVKNASGTKAVSVMV-----KVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGG 22672
Query: 1321 -----WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA-DVEMN 1374
+IV + + + + S + ++ + I+++R N G VE
Sbjct: 22673 AEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESE 22732
Query: 1375 VTILDK----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV 1430
+ PSPPG P + I I W +PE+ G + I Y+V+ +E + W V
Sbjct: 22733 PIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRV 22792
Query: 1431 KN---ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP----- 1482
+ T+ + +L Y+FR AVN S+ SE + + + + P
Sbjct: 22793 NKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPR 22852
Query: 1483 ---TVEKPLKNITTEPNEDIELTCIFGGV--PQPKVT--WYRDGKKLKTAKATYENRXXX 1535
T + + T+P D T I G V Q K T WYR AT N
Sbjct: 22853 VVDTTKHSISLAWTKPMYDGG-TDIVGYVLEMQEKDTDQWYR-----VHTNATIRN-TEF 22905
Query: 1536 XXXXXXXXXXXXYKCIAFNDHGEVETS-CVVGIQQKPVITISN----EDIKQKHKV--GD 1588
++ A N G E S + I+ I I + +D+K+ + G
Sbjct: 22906 TVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGA 22965
Query: 1589 EWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEAS 1648
+ + G PPP + W K G L + I T E S++ + ++ R + KYTIEA
Sbjct: 22966 SLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLIVDKVNRYDAGKYTIEAE 23023
Query: 1649 NTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
N +G S V +KVYD P P V ++E+SR+SVTI W+ P DGG + Y +EK E
Sbjct: 23024 NQSGKKSATVLVKVYDTPG-PCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREA 23082
Query: 1709 DNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPS 1768
R K Y I L E Y FRV+ +N G E E+ V+ + +VP
Sbjct: 23083 AM-RAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVS--EVP- 23138
Query: 1769 XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARIQ 1827
+ +V + W +GGS + Y +E + G ++W
Sbjct: 23139 LVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHT 23198
Query: 1828 KLSINT--TYQFRIYARNEIGTSLPYTSDDKITIGK-----TLTPPSQPRNFVVSESTSR 1880
S+N Y FRI A+NE G S P + +T+ T+ + P+ + R
Sbjct: 23199 VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQK-TIHVPAGR 23257
Query: 1881 SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
V L P + P ++ ++ +S V V + I +D + +
Sbjct: 23258 PVEL--VIPIAGRPPPAASWFFAGSKLR-ESERVTVETHTKVAKLTIRETTIRDTGEYTL 23314
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
+N G + T + + L+K P PPT P++I + + + SW PE DGGAPL G
Sbjct: 23315 ELKNVTGTTSET-IKVIILDK----PGPPTGPIKIDEIDATSITISWEPPELDGGAPLSG 23369
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
Y + RD + W+ V + V F L+E + Y+ R+ A N G+ L+S+
Sbjct: 23370 YVVEQRDAHRPGWLPVSE-SVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 23424
Score = 208 bits (508), Expect = 2e-52
Identities = 225/926 (24%), Positives = 383/926 (41%), Gaps = 55/926 (5%)
Query: 1161 QKLKIYDCDLDDAG--EYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
Q+ KI C L+ G E + G K L E P ++ L + I+V A A + +
Sbjct: 17492 QEYKIRVCALNKVGLGEATSVPGTVKPEDKL--EAPELDLDSELRKGIVVRAGGSARIHI 17549
Query: 1219 EIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
T ++TW +++ E T+K + V L I C +D +Y L ++ +
Sbjct: 17550 PFKGRPTPEITWSREEG--EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSK 17607
Query: 1278 K--LKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ V+V++ P + +K + + ++ P + V + +I K + T+
Sbjct: 17608 SAFVTVKVLDTPGP----PQNLAVKEVRKDSAFLVWEP-PIIDGGAKVKNYVIDKRESTR 17662
Query: 1336 PSIDSKSA--SLTIKKVEN-TDAGIYKLRL--ENNCG-HADVEM--NVTILDKPSPPGKP 1387
+ + S+ S T KVEN T+ IY R+ EN G VE V + PSPPGK
Sbjct: 17663 KAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKV 17722
Query: 1388 NILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNS 1447
+ ++ +S ++ W++PE+ G S ++ YVVE Q T +W V + L +
Sbjct: 17723 TLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQ 17782
Query: 1448 SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
Y+FR A NE SD + K+ IQ P+++ P + + ED+++ G
Sbjct: 17783 EYQFRVKAYNEKGKSD-PRVLGVPVIAKDLTIQ-PSLKLPFNTYSIQAGEDLKIEIPVIG 17840
Query: 1508 VPQPKVTWYRDGKKLK-TAKATYENRXXXX---XXXXXXXXXXXYKCIAFNDHGEVETSC 1563
P+P ++W +DG+ LK T + E Y A N G +
Sbjct: 17841 RPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENL 17900
Query: 1564 VVGIQQK---PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
V + +K PV + +++ V W A G I K +
Sbjct: 17901 SVIVLEKPGPPVGPVRFDEVSADFVV-ISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVS 17959
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS----SVEVTLKVYDKPSKPEGPVIMR 1676
T T I+I +LK ++ I A N G S S V ++ K P G +
Sbjct: 17960 ATVARTT--IKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVT 18017
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCE 1736
IS++ + ++W P++DGG ++ Y +E+ E ++ W+K+ + L+E E
Sbjct: 18018 SISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLE 18077
Query: 1737 YMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNG 1795
Y F+V A+N VG + + SE V + D P I +V + W +G
Sbjct: 18078 YEFKVSAENIVGIGKPSKVSECFVARDPCDPPG----RPEAIVITRNNVTLKWKKPAYDG 18133
Query: 1796 GSPIIDYKVEIKQ--EGKKWKXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGT-SLPY 1851
GS I Y VE K +G+ K + L + Y+FR+ ARN G S P
Sbjct: 18134 GSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPS 18193
Query: 1852 TSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS 1911
S IT + P+ + + + G PI + + + +
Sbjct: 18194 DSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEE 18253
Query: 1912 WTKIVTVGGSVHEH--CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP 1969
+ + ++ + +++ D + + N G T+S + + K P PP
Sbjct: 18254 TAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGG----TKSIPITV-KVLDRPGPP 18308
Query: 1970 TAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIR 2029
PL++ V + +W P DGGA + Y I R+ ++ W +V +V L + +
Sbjct: 18309 EGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV-STEVQALNYKVT 18367
Query: 2030 DLSENHTYMIRIYARNEIGLSEPLES 2055
L + Y+ R+ A N+ G+ EPLES
Sbjct: 18368 KLLPGNEYIFRVMAVNKYGIGEPLES 18393
Score = 208 bits (507), Expect = 2e-52
Identities = 223/960 (23%), Positives = 396/960 (41%), Gaps = 70/960 (7%)
Query: 750 ESVILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ VIL ++ P + W K+ K P K K+DG + ILK D G YT
Sbjct: 5536 DEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKKRML-ILKKALKSDIGQYTCD 5593
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
G +TS + +E+ + P + V E T + ++ + + + W
Sbjct: 5594 C----GTDKTSGKLDIEDREIKLVRP------LHSVEVMETETARFETEISEDDIHA-NW 5642
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
E + + +G+ LV+ N + +G A+N KSS RV V
Sbjct: 5643 KLKGEALLQTPDCEIKEEGKIHSLVLHNCRLD-QTGGVDFQAANV--KSSAHLRVKPRV- 5698
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
+ ++ L K G+T +C+ S+ + +WY K++ D EG+
Sbjct: 5699 -IGLLRPL-KDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLT 5756
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G ++ KD +T L VKE EF + L+D V+E A+LE E++ E A
Sbjct: 5757 LRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENA 5816
Query: 1046 DVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
V W ++G EI+K KK Y+ G +RKL I + + D Y+C +D + + VV
Sbjct: 5817 KVKWFKNGTEILKSKK--YEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVP 5874
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
E + L + +V + A FE EL++ +A V+WFKDG+EI+ + G + L
Sbjct: 5875 PHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILV 5934
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
I C LDD EYSCEV ++ + +LTV E FT L I V L E+
Sbjct: 5935 INKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLAN-IEVSETDTIKLVCEVSKPG 5993
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+V WYK I +T ++ ++++ +KR L+I+ +D Y C L S T KV+V
Sbjct: 5994 AEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRL--PSSRTDGKVKVH 6051
Query: 1285 EFPPKIVDYEREYRIKRG--SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
E + + + I G ++ + ++FP +W + K ++ D K
Sbjct: 6052 ELAAEFISKPQNLEILEGEKAEFVCSISKESFPV---QWKRDDKTLESGDKYDVIADGKK 6108
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS--PPGKPNILEIDSSSINIC 1400
L +K D G Y + + G A ++T+++K P K ++ + C
Sbjct: 6109 RVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNC 6164
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
NT + ++ E D++++I ++ I++ + + N
Sbjct: 6165 ---EVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRG 6221
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK 1520
+ S +++E ++ + +PLK+I T + + C + + W ++G+
Sbjct: 6222 ENVKSAAN---LIVEEEDLR---IVEPLKDIETMEKKSVTFWCKVNRL-NVTLKWTKNGE 6274
Query: 1521 KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE--VETSCVVGIQQKPVITISNE 1578
++ ++NR K F D GE V + + +I E
Sbjct: 6275 EV-----PFDNR--VSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTE 6327
Query: 1579 DIKQKHKVGDEWLVTAVIE---GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
++ AV V WY+NG +++ K+Y + IK+
Sbjct: 6328 FVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDC 6387
Query: 1636 KRSHSSKYTIEASNTAGTSSV---EVTLKVYDKPSK-PEGP----VIMREISRESVTIEW 1687
+ +Y + + + E+ +++ P E P V + E++++ V ++W
Sbjct: 6388 RLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQW 6447
Score = 205 bits (501), Expect = 1e-51
Identities = 229/937 (24%), Positives = 390/937 (41%), Gaps = 70/937 (7%)
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
+ ++ K++IY + + GE + G K + E ++ LR + + + A L
Sbjct: 15326 ENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLR--KVVTIRACCTLRL 15383
Query: 1217 TVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
V I +V W + E +K ++ S LI+ D +Y + ++
Sbjct: 15384 FVPIKGRPAPEVKWARDHG--ESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSG 15441
Query: 1276 TTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH 1333
+ + V V++ P D + + K + VTL D P + + + I++K +
Sbjct: 15442 SKSAFVNVRVLDTPGPPQDLKVKEVTK--TSVTLTWDP---PLLDGGSKIKNYIVEKRES 15496
Query: 1334 TKPSIDSKSASL--TIKKVENTDAGI---YKLRLENNCG---HADVEMNVTILDKPSPPG 1385
T+ + + + + T KV+ G +++ EN G A+ +V ++P PPG
Sbjct: 15497 TRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPG 15556
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKT 1445
K ++++ +S+++ W++PE+ G S I+ Y+VE Q + +W + + T+ +I L
Sbjct: 15557 KITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQ 15616
Query: 1446 NSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF 1505
Y FR A NE ISD + + VI + + P + T ED+++ F
Sbjct: 15617 GEEYSFRVSAQNEKGISDPRQLS--VPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPF 15674
Query: 1506 GGVPQPKVTWYRDGKKLK-----TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
G P P VTW++D LK A++T EN Y N GE
Sbjct: 15675 IGRPTPAVTWHKDNVPLKQTTRVNAEST-ENNSLLTIKDACREDVGHYVVKLTNSAGEAI 15733
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN----D 1616
+ V + KP +K DE ++ PP+ Y G+ + N
Sbjct: 15734 ETLNVIVLDKP--GPPTGPVKM-----DEVTADSITLSWGPPK---YDGGSSINNYIVEK 15783
Query: 1617 KEYNITTKEKTS------VIRIKELKRSHSSKYTIEASNTAGTSSV---EVTLKVYD-KP 1666
++ + TT + S I+ LK ++ I A N G S+ E T+ Y K
Sbjct: 15784 RDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKV 15843
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
P G ++ SR+S+ ++W P+ DGG + Y +E+ E ++ W+K+ +
Sbjct: 15844 PGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKF 15903
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
L E EY FRV A+N VG + + SE V + D P + SV
Sbjct: 15904 KTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPG----RPEAIIVTRNSVT 15959
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQ--EGKKWKXX-XXXXXXXARIQKLSINTTYQFRIYAR 1842
+ W +GGS I Y VE K+ EG+ K + L + Y+FR+ AR
Sbjct: 15960 LQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIAR 16019
Query: 1843 NEIGT-SLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
N G S P S IT + PP + ++ + G PI I
Sbjct: 16020 NAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPT-I 16078
Query: 1902 IEFKTVKGKSWTKIVTVGGS--VHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
K + S T + + + +++ D + + A+N G T + V L
Sbjct: 16079 QWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKV-L 16137
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
++ P PP P+ I V + +W P DGG+ ++ Y + R+ ++ +W V
Sbjct: 16138 DR----PGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVV-DA 16192
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
+V TL + L E + Y RI A N+ G+ EPLES+
Sbjct: 16193 NVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESE 16229
Score = 205 bits (500), Expect = 2e-51
Identities = 228/1047 (21%), Positives = 410/1047 (39%), Gaps = 71/1047 (6%)
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
+E+ P + V + ++ + A V W KDG ++ + + ++
Sbjct: 18894 IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVT 18953
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCT-----AILTVEEPSINFTLRLPEFILVPANTDAYL 1216
L I + +D G Y V NS + I+ ++ P +R+ E + + T ++
Sbjct: 18954 SLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDE-VSCDSITISWN 19012
Query: 1217 TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLI--IRKCTEDDQCEYTCV--LLD 1272
E D ++ Y + + + ++S RT I +R T + C
Sbjct: 19013 PPEY-DGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYG 19071
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
S ++ V E+P ++ + T+LV +Q ++ + + K
Sbjct: 19072 KSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHL--EYK 19129
Query: 1333 HTKPSIDSKSASLTIK----KVENTDAGI---YKLRLENNCGHADVEMN---VTILDKPS 1382
+ SK+ + I KV D G+ Y++ EN G + V D
Sbjct: 19130 ERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCD 19189
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK--NITKTQTSI 1440
PPG+P + I S+++ W +P G + I Y+VE +E+ W+ NI +T +
Sbjct: 19190 PPGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEV 19249
Query: 1441 QNLKTNSSYRFRAYAVNEVD-ISDASETTEYYKVIKETKIQSPTVEKPLKN---ITTEPN 1496
L + Y FR +A N D +S+ SE+T +I + ++ P V +K I +
Sbjct: 19250 TELTEDQRYEFRVFARNAADSVSEPSESTG--PIIVKDDVEPPRVMMDVKFRDVIVVKAG 19307
Query: 1497 EDIELTCIFGGVPQPKVTWYRDG----KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIA 1552
E +++ G P P ++W +DG ++ +T + +N Y
Sbjct: 19308 EVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTL 19367
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIK--QKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
N G + + KP +I K W G ++ +Y
Sbjct: 19368 KNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGA---DIDYYIVE 19424
Query: 1611 NKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAGTSSV--EVTLKVYDKPS 1667
+ + + I E + + ++ +L + + + + N G V +K D +
Sbjct: 19425 KRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFT 19484
Query: 1668 KPEGPVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P P + +++ES+T+ W P DGG E++ Y IE+ E ++ RW++V + V
Sbjct: 19485 VPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNK--KPVYD 19542
Query: 1726 YCIQK--LNENCEYMFRVIAQNPVGFSEALESEPIV-IKTALDVPSXXXXXXXXXXIDNE 1782
++ L E CEY +RV A+N G S E+ P++ + + +PS
Sbjct: 19543 LRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDS-GKT 19601
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXXXXXXXXA-RIQKLSINTTYQFRIY 1840
++ I W +GG+PI Y VE K+ + WK I L+ Y FR+
Sbjct: 19602 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 19661
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
+ N++G S P S D + P + + ++ +T G P+ N
Sbjct: 19662 SVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPN- 19720
Query: 1901 IIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLE 1960
++ K V S IEN D + ++ +N + + T +
Sbjct: 19721 VLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLT-----LVV 19775
Query: 1961 KHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD 2020
K P PPT + ++ V + SW PE DGGAP+ Y+I R+ +K W+ V +
Sbjct: 19776 KVLDTPGPPTN-ITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTN-N 19833
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVX 2080
N L + + +L E Y R+ NE G+ P E+ E K+ E+P ++
Sbjct: 19834 CNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKI--------TEKPSPPEKLG 19885
Query: 2081 XXXXXXXXXXXXWLR-EHNMDADIRSY 2106
WL+ EH+ + I Y
Sbjct: 19886 VTSISKDSVSLTWLKPEHDGGSRIVHY 19912
Score = 202 bits (494), Expect = 8e-51
Identities = 174/670 (25%), Positives = 270/670 (40%), Gaps = 36/670 (5%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMN 1374
P P W + K + ++ +KS L IK D G Y + N+CG
Sbjct: 8635 PVPTKVWTKEEGELDKDRVVIDNVGTKS-ELIIKDALRKDHGRYVITATNSCGSKFAAAR 8693
Query: 1375 VTILDKPSP--PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN 1432
V + D P P KP + +N W +PE+ G S I +++E ++ W
Sbjct: 8694 VEVFDVPGPVLDLKPVVTNRKMCLLN--WSDPEDDGGSEITGFIIERKDAKMHTWRQPIE 8751
Query: 1433 ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNIT 1492
+++ I L Y+FR A N+ E V SP +
Sbjct: 8752 TERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTK 8811
Query: 1493 TEPNEDIELTCIFGGVP-QPKVTWYR--DGKKLKTAKATYENRXXXXXXXXXXXXXXXYK 1549
+ D + GG P Q + R D + ++
Sbjct: 8812 STITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFR 8871
Query: 1550 CIAFNDHGEVETSCVVGI-----QQKPVITI--SNEDIKQKHKVGDEWLVTAVIEGIPPP 1602
A N+ GE E S + + + P I + S K K G+ + A + G+P P
Sbjct: 8872 VKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMP 8931
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTS------VIRIKELKRSHSSKYTIEASNTAGTSSV 1656
++ W KN +E + TKE+ S + I + R YT+ ASN G+
Sbjct: 8932 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 8991
Query: 1657 EVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WI 1714
V ++VYD+PS P + + +I ES + W PLD+GG E+T Y I+K + + W
Sbjct: 8992 NVHVEVYDRPSPPRN-LAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWE 9050
Query: 1715 KVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXX 1774
+V + + + Y I KL N +Y FRV A N G S+ +S+ +VI+ +P
Sbjct: 9051 EVTNTAVE-KRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPK 9109
Query: 1775 XXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSINT 1833
S+ ++W P NGGSPI Y +E ++EG W ++ + N
Sbjct: 9110 VLARTKG-SMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGVEFNV 9168
Query: 1834 T-------YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKW 1886
YQFR A N G P D G + PP P V + T S++L W
Sbjct: 9169 PRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGW 9228
Query: 1887 TEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVH--EHCIENIKEKDEIIFRISAEN 1944
P +GGSPI YI+E + W ++ + E + N+KE + FR+ A N
Sbjct: 9229 KPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVN 9288
Query: 1945 TVGVSLPTES 1954
G S P+++
Sbjct: 9289 EAGESEPSDT 9298
Score = 202 bits (494), Expect = 8e-51
Identities = 217/903 (24%), Positives = 372/903 (41%), Gaps = 67/903 (7%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVT-WYKKKSVIEDTEKFTLISDVKKRT 1252
PS+ ++L E ++V A T I + W S I+ E +T+ +D
Sbjct: 11011 PSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV 11070
Query: 1253 LIIRKCTEDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD 1310
L I+ C D EY + +A T + + V++ P I + + +
Sbjct: 11071 LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTG---PINILDVTPEHMTIS 11127
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPS--IDSKSASLTIKKVENTDAG---IYKLRLENN 1365
+Q ++N I++K K + + S +S T K+ + G ++++R EN
Sbjct: 11128 WQPPKDDGGSPVINY-IVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENK 11186
Query: 1366 CGHAD-VEMNVTI----LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
G ++ T+ PSPPGKP + +I ++ + W P++ G S I Y +E +
Sbjct: 11187 IGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERR 11246
Query: 1421 EIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK 1478
E+ T +W+ V I + + L ++Y FR +A N +S S +++ K + K
Sbjct: 11247 EV-TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIK 11305
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXX 1538
P + LK+ + E D+ T P + + + +K TA+ N+
Sbjct: 11306 PPGPPINPKLKDKSRE-TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQ 11364
Query: 1539 XXXXX------XXXXYKCIAFNDHGE------VETSCVVGIQQKPVIT--ISNEDIKQKH 1584
++ A N GE E+ I P + ++ D+
Sbjct: 11365 CAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITV- 11423
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VG + A ++G P P++ W K G L +K ++ ++IKE R+ KY
Sbjct: 11424 RVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYI 11483
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
I A N++G + + V D+P P + + +++E+ TI W+ PLD+GG E+T + +E
Sbjct: 11484 ISAKNSSGHAQGSAIVNVLDRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVE 11542
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQ-KLNENCEYMFRVIAQNPVGFSEALESE-PIVIKT 1762
+P+ W VA DV I+ L N EY FRV A+N VG +E++ PI+
Sbjct: 11543 YRKPNQKGWSIVAS---DVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAIN 11599
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXX 1821
+D P VY+ W + +GGSP + Y VE + +G W+
Sbjct: 11600 PIDRPGEPENLHIADK-GKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSI 11658
Query: 1822 XXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTS 1879
+ + N Y+FR+ +NE G S + +++ + + L P V+ S
Sbjct: 11659 KETHYMVDRCVENQIYEFRVQTKNEGGES-DWVKTEEVVVKEDLQKP------VLDLKLS 11711
Query: 1880 RSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-------VTVGGSVHEHCIENIKE 1932
+T+K + E K K T + + + + K
Sbjct: 11712 GVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKR 11771
Query: 1933 KDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW 1992
D + ++A NT G + + +V L+K P L+I V S+ W PE
Sbjct: 11772 SDGGKYVVTATNTAGSFVAYATVNV-LDKPG-----PVRNLKIVDVSSDRCTVCWDPPED 11825
Query: 1993 DGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
DGG + Y I + TK M V T + L E + Y+ R+ A N+IG P
Sbjct: 11826 DGGCEIQNY-ILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPP 11884
Query: 2053 LES 2055
ES
Sbjct: 11885 TES 11887
Score = 202 bits (493), Expect = 1e-50
Identities = 182/753 (24%), Positives = 322/753 (42%), Gaps = 44/753 (5%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V E + EC + P+ WL +EI D+ + + H V+K +
Sbjct: 5354 VFEKDEAKFECEVSREPKT-FRWLKGTQEITGDDRFELIKDGTKHSM--VIKSAAFE--D 5408
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
E Y A ++ L I+ I+ + + PLK + ++ ES + + ++ +
Sbjct: 5409 EAKYMFEAEDKHTSGKL-IIEGIRL------KFLTPLKDVTAKEKESAVFTVEL-SHDNI 5460
Query: 765 TITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
+ W KN++ + +++ + +G THSIT K + D ++A + A +T
Sbjct: 5461 RVKWFKNDQRLHTTRSVSMQDEGKTHSITF-KDLSIDDTSQIRVEAMGMS----SEAKLT 5515
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
V E P F + Q+ T EK + L +++ P + W+++ + I PS+
Sbjct: 5516 VLEGD------PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVI 5568
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE 941
DG+ L++ + D G Y C G ++ I+ ++ V+ L S E
Sbjct: 5569 KADGKKRMLILKKA-LKSDIGQYTC----DCGTDKTSGKLDIEDREIKLVRPLH-SVEVM 5622
Query: 942 EGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
E +T E + S + W + + EI +EG+ G +
Sbjct: 5623 ETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQ 5682
Query: 1001 VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKK 1060
+ ++S L VK + +R L+D V + A + E++ E V W G+ ++P
Sbjct: 5683 AANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPS- 5741
Query: 1061 NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNK 1120
+K G + L +R+ + D GE +D A + V E P E L++Q V +
Sbjct: 5742 DKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEE 5801
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
G A E E+++ +A V+WFK+G+EI S ++ DG+ +KL I+DC +D Y+C+
Sbjct: 5802 GATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDA 5861
Query: 1181 GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE 1240
+ K + L V P + F L + + V A E+ E V W+K + I+ +
Sbjct: 5862 KDFKTSCNLNVVPPHVEFLRPLTD-LQVREKEMARFECELSRENAKVKWFKDGAEIKKGK 5920
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV--EVVEFPPKIVDYEREYR 1298
K+ +IS R L+I KC DD+ EY+C + A+++ L V E F + + E
Sbjct: 5921 KYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVSE- 5979
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
+D LV + P W + I + + + + L I+ DAG Y
Sbjct: 5980 ----TDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNY 6035
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
RL ++ V+++ + S P ILE
Sbjct: 6036 NCRLPSSRTDGKVKVHELAAEFISKPQNLEILE 6068
Score = 202 bits (493), Expect = 1e-50
Identities = 187/693 (26%), Positives = 290/693 (41%), Gaps = 34/693 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQT 1438
P P P + + S+ + W+ P + G S I+ YV+E ++ + W I + +
Sbjct: 16240 PDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRL 16299
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
+ L N Y FR A N +S+ S + Y K P + +IT
Sbjct: 16300 RVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFL 16359
Query: 1499 IELTCIF-GGVP-QPKVTWYRD---GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
I+ GG Q + D G+ T N+ ++ A
Sbjct: 16360 SWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAI 16419
Query: 1554 NDHGEVETSCVVG---IQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIW 1606
N G E + V G +++K P I + E K + + G + I+G P PEV W
Sbjct: 16420 NKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW 16479
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
K ++ + ++T+ TS++ + + R S KYT+ N++GT S VT++V D P
Sbjct: 16480 GKVDGEIRDAAIIDVTSSF-TSLV-LDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTP 16537
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
S P + + EI+++SV+I W+PPL DGG ++ Y +EK E + V + ++
Sbjct: 16538 SPPVN-LKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVV-TNCHKNSW 16595
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFS-EALESEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
I +L E C Y FRV A+N G A ++PI + P + SV
Sbjct: 16596 KIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPG----KITVDDVTRNSVS 16651
Query: 1786 ITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNE 1844
++W E +GGS II Y VE++ + +KW A I L+ Y FR+ A NE
Sbjct: 16652 LSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNE 16711
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEF 1904
G S P + I + K L + S S LK P S P + +
Sbjct: 16712 KGRSDPRSLAVPI-VAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDG 16770
Query: 1905 KTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHA 1963
+ K T+I VT + I+ + D + I+ N VG + V L+K
Sbjct: 16771 LPL--KQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVG-QKTASIEIVTLDK-- 16825
Query: 1964 TVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
P PP P++ V + + SW P + GG + Y + RD T T+W +V V
Sbjct: 16826 --PDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVW-DVVSATVAR 16882
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
+ L Y RI+A N G S LESD
Sbjct: 16883 TTLKVTKLKTGTEYQFRIFAENRYGQSFALESD 16915
Score = 200 bits (488), Expect = 4e-50
Identities = 172/697 (24%), Positives = 288/697 (41%), Gaps = 38/697 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK---TQ 1437
P PP P++ + S ++ W +P G I YVVE+Q++ WI T TQ
Sbjct: 14176 PGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ 14235
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE 1497
+ +L+T Y FR A+N+ + + + + V +E + + +
Sbjct: 14236 FVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGL 14295
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXX-XXXXXYKCIAFNDH 1556
I + G P P+VTW +D LK +A EN K + ++
Sbjct: 14296 SIRIFVPIKGRPAPEVTWTKDNINLKN-RANIENTESFTLLIIPECNRYDTGKFVMTIEN 14354
Query: 1557 GEVETSCVVGIQ----QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
+ S V ++ PV+ + DI K V W + + G + Y +
Sbjct: 14355 PAGKKSGFVNVRVLDTPGPVLNLRPTDIT-KDSVTLHWDLPLIDGG---SRITNYIVEKR 14410
Query: 1613 LENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS-VEVT--LKVYDKPSK 1668
K Y+ TTK ++ L + + A N G E T +K + PS
Sbjct: 14411 EATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP 14470
Query: 1669 PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCI 1728
P+ IM +I++ +V++ W P DGG ++T Y IE +++W + V + +E +
Sbjct: 14471 PDSLNIM-DITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV-KGLECV-V 14527
Query: 1729 QKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXI-----DNES 1783
+ L E EY F+V+A N G S ES P+++K +P + DN
Sbjct: 14528 RNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIK 14587
Query: 1784 VYITWFPSEKNGGSPIIDYKV--EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
V I K P + +K +I ++ ++ I + + + + + A
Sbjct: 14588 VEIPVLGRPK----PTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTA 14643
Query: 1842 RNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
RN +G + I + PP+ P F E +S VT W PE++GG PI+NY+
Sbjct: 14644 RNIVGEVGDVIT---IQVHDIPGPPTGPIKF--DEVSSDFVTFSWDPPENDGGVPISNYV 14698
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
+E + +W ++ T + + E FR+ A+N GV S +
Sbjct: 14699 VEMRQTDSTTWVELATTVIRT-TYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANY 14757
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
VP PP P ++ V + + SW P DGG+P+LGY++ ++ +W V K V
Sbjct: 14758 PFKVPGPPGTP-QVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALV 14816
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
F L++ Y R+ A N G S+P + EP
Sbjct: 14817 PGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEP 14853
Score = 199 bits (485), Expect = 1e-49
Identities = 194/869 (22%), Positives = 358/869 (41%), Gaps = 53/869 (6%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVV 1284
VTW + + ++ T+ + +++I+ C Q Y+ + + K + V+V+
Sbjct: 10059 VTWNMNERTLP--QEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 10116
Query: 1285 EFP-PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
+ P P + +T P +++ + + T +
Sbjct: 10117 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 10176
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHAD-VEMNVTILDK-----PSPPGKPNILEIDSSSI 1397
+ T++ + A +++ EN+ G VE + ++ + P P + E+ +++
Sbjct: 10177 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 10236
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYA 1455
+ W+ P+ G S II YV+E + I T ++ V N + + +++ LK +Y +R A
Sbjct: 10237 TLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSA 10296
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNEDIELTCIFGGVPQPKVT 1514
VN V S T+ + + ++ PT+ ++ +T E LT + G P+PKV+
Sbjct: 10297 VNIVGQGKPSFCTK--PITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVS 10354
Query: 1515 WYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
W++D + +T T Y + N G + C V + +
Sbjct: 10355 WFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDR 10414
Query: 1571 ---PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
PV +S +++ + + V W G I K ++ D +T+
Sbjct: 10415 PGPPVGPVSFDEVTKDYMV-ISWKPPLDDGGSKITNYIIEK--KEVGKDVWMPVTSASAK 10471
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSS--VEVTLKVYDK---PSKPEGPVIMREISRES 1682
+ ++ +L + I A N G S V ++K D+ P P+ P++ E++++S
Sbjct: 10472 TTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIV-TEVTKDS 10530
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEYMFRV 1741
+ W P DGG +T Y +EK E + RW +V D + + L E C+Y FRV
Sbjct: 10531 ALVTWNKP-HDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRV 10589
Query: 1742 IAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
A+N +G + + S+P+ K + PS N SV +TW P +GGS I+
Sbjct: 10590 SAENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCN-SVDLTWQPPRHDGGSKIL 10648
Query: 1801 DYKVEIKQEG-KKWKXXXXX----XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDD 1855
Y VE ++ G ++W+ ++ L TY+FR+ A N G S P +
Sbjct: 10649 GYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE 10708
Query: 1856 KITIGKTLTPPS--QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWT 1913
+ + L PP N + TL+ + P + E + K+
Sbjct: 10709 PVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARI 10768
Query: 1914 KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPL 1973
+ VG + I N +D I+ ++ EN G S + + L+K P PP L
Sbjct: 10769 DVTPVGSKLE---IRNAAHEDGGIYSLTVENPAG-SKTVSVKVLVLDK----PGPP-RDL 10819
Query: 1974 EIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSE 2033
E+ + + +W P DGG+ + Y + RDV W + F + L+E
Sbjct: 10820 EVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHF-AKHLNE 10878
Query: 2034 NHTYMIRIYARNEIGLSEPLESDEPFKVI 2062
+ Y+ R+ A N+ G +E+ +P K +
Sbjct: 10879 GNQYLFRVAAENQYGRGPFVETPKPIKAL 10907
Score = 198 bits (483), Expect = 2e-49
Identities = 131/433 (30%), Positives = 196/433 (45%), Gaps = 19/433 (4%)
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN--GNKLENDKEYNITTKEK 1626
QKPV+ + + K GD + A + G P PEV W K+ L I T+
Sbjct: 11702 QKPVLDLKLSGVLTV-KAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRAD 11760
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+S + + KRS KY + A+NTAG+ T+ V DKP I+ ++S + T+
Sbjct: 11761 SSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIV-DVSSDRCTVC 11819
Query: 1687 WKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNP 1746
W PP DDGG E+ Y +EK E W + T + +L E EY+FRV A+N
Sbjct: 11820 WDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT-TVTRLIEGNEYIFRVRAENK 11878
Query: 1747 VGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
+G ES+P++ KT D P + E + + W P E +GG I Y +E
Sbjct: 11879 IGTGPPTESKPVIAKTKYDKPGRPDPPEVTK-VSKEEMTVVWNPPEYDGGKSITGYFLEK 11937
Query: 1807 KQE-GKKWKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTL 1863
K++ +W R +Q L + YQFR+ A NEIG P + +
Sbjct: 11938 KEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPI 11997
Query: 1864 TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK-----TVKGKSWTKIVTV 1918
PP P NF V ++T S+TL W +P +GG+PI Y++E + + W +
Sbjct: 11998 EPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAA 12057
Query: 1919 GGSVH-EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM 1977
V E + ++ E E FR+ A+N VG+ P E + K + PP L+ M
Sbjct: 12058 AQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKE--ILEPPEIDLDASM 12115
Query: 1978 VGSNIVMTSWGTP 1990
+V+ G P
Sbjct: 12116 --RKLVIVRAGCP 12126
Score = 198 bits (483), Expect = 2e-49
Identities = 168/659 (25%), Positives = 292/659 (44%), Gaps = 41/659 (6%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVE 1192
++W++ G E+ S +++ DG+ L + + +D G Y+C EVG + ++ L ++
Sbjct: 24067 IKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ 24126
Query: 1193 E-PSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKK 1250
P + L E + L V + +TW+ + +++++E T+ +
Sbjct: 24127 ATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHY 24186
Query: 1251 RTLIIRKCTEDDQC-EYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
L+++ +Y L + T L VE+ + P K + + S V
Sbjct: 24187 THLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAV-- 24244
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPS---IDSKSASLTIKKVENT--DAGIY-KLR 1361
+ ++ WI N +++KC+ + + + S + S+T ++ N +AG Y ++
Sbjct: 24245 -ISWKPPADDGGSWITNY-VVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVS 24302
Query: 1362 LENNCGHAD-VEMNVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
+N G +D +E++ ++ +KP PGKP I + S + W P + G + I Y
Sbjct: 24303 AQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNY 24362
Query: 1416 VVEYQEIDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
+E +E +WISV + I +T S++NL Y FR N S+ SE +E
Sbjct: 24363 YLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITP 24422
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRX 1533
+ IQ+P ++ L+N+ + L C G P+P V WYR GK++ Y +
Sbjct: 24423 KSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQE 24482
Query: 1534 XXXX------XXXXXXXXXXYKCIAFNDHGEVE--TSCVVGIQQKPVITISNEDIKQKHK 1585
Y+ A N G V S V + K + + E + H
Sbjct: 24483 FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHA 24542
Query: 1586 V-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN-ITTKEKTSVIRIKELKRSHSSKY 1643
+ G+ + G P P + W K + ++N+ Y I T+ TS++ ++R + Y
Sbjct: 24543 LRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFY 24602
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAI 1703
+ A N G V L V D P P G V + ++SR+SV + W P DGG ++T Y +
Sbjct: 24603 VVCAKNRFGIDQKTVELDVADVPDPPRG-VKVSDVSRDSVNLTWTEPASDGGSKITNYIV 24661
Query: 1704 EKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIK 1761
EK RW++V R+ Y + L Y FRVIA+N G S+ E SEP + K
Sbjct: 24662 EKCATTAERWLRVGQA-RETR-YTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITK 24718
Score = 196 bits (477), Expect = 9e-49
Identities = 175/699 (25%), Positives = 298/699 (42%), Gaps = 44/699 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKTQ 1437
P PP P + + SS+++ W +P G + + YVVE +E EW + + Q
Sbjct: 18506 PGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQ 18565
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITTE 1494
++ LK N+ Y FR A+N + + + T V+ + +I+ P +E K +
Sbjct: 18566 FTVTKLKENTEYNFRICAINSEGVGEPA--TLPGSVVAQERIEPPEIELDADLRKVVVLR 18623
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCI 1551
+ + L G P+P+V W + + + T +A E + Y
Sbjct: 18624 ASATLRLFVTIKGRPEPEVKWEK-AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLT 18682
Query: 1552 AFNDHGEVETSCVVGIQQKP--VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
N+ G V + P + ++ ++K K V W +I+G ++ Y
Sbjct: 18683 LENNSGSKTAFVNVRVLDSPSAPVNLTIREVK-KDSVTLSW-EPPLIDG--GAKITNYIV 18738
Query: 1610 GNKLENDKEY-NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS-SVEVTLKV-YDKP 1666
+ K Y IT + RI+ L+ S + + ASN G E T V +P
Sbjct: 18739 EKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEP 18798
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
P G V + +++R + TI+W+ P DGG ++T Y +E + +W V + +E
Sbjct: 18799 PLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQV-KTLEA- 18856
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
I L EY+FRV A N G S+ + P++ + PS E +
Sbjct: 18857 TISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLK 18916
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXAR-IQKLSINTTYQFRIYARNE 1844
I P + G P V +++G+ K ++ + LSI ++ +
Sbjct: 18917 ID-VPFK---GRP--QATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEA------SKED 18964
Query: 1845 IGTSLPYTSDD--KITIGKT---LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
+GT S+ IT+ T L P P + E + S+T+ W PE +GG I+N
Sbjct: 18965 VGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISN 19024
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
YI+E K +W IV+ + I + E FR+ AEN G S +ES +V
Sbjct: 19025 YIVEKKETTSTTW-HIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVA 19083
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
E + P PP P + S +++T W P DGG+ ++GY++ ++ + +W + K+
Sbjct: 19084 EYPFSPPGPPGTPKVVHATKSTMLVT-WQVPVNDGGSRVIGYHLEYKERSSILWSKANKI 19142
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ + + L E Y R+YA N G+ + +S EP
Sbjct: 19143 LIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEP 19181
Score = 195 bits (475), Expect = 2e-48
Identities = 186/711 (26%), Positives = 309/711 (43%), Gaps = 65/711 (9%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKTQ 1437
P+PP P + + SS+++ W +P G S II Y+VE + D+ W+ +N+ KT+
Sbjct: 13092 PAPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTR 13151
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL-KNITTEPN 1496
+ L ++ Y+FR YAVN++ SD S+ + + ++ L K +
Sbjct: 13152 FEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAG 13211
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTA-----KATYENRXXXXXXXXXXXXXXXYKCI 1551
+ L G P PK+TW + L+ K+T + Y
Sbjct: 13212 VTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKST-DFDTFLRCENVNKYDAGKYILT 13270
Query: 1552 AFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT---AVIEGIPPPEVIWYK 1608
N G+ E + VV + P + N +K+ K D VT +I+G P +I Y
Sbjct: 13271 LENSCGKKEYTIVVKVLDTPGPPV-NVTVKEISK--DSAYVTWEPPIIDGGSP--IINYV 13325
Query: 1609 NGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ K ++ T E KTS R+ L+ S + + A N G T K
Sbjct: 13326 VQKRDAERKSWSTVTTECSKTS-FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAV-KA 13383
Query: 1667 SKPEGPVI---MREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
S+ GPV+ +R +S+ S +I WK P DGG + Y ++ + N+W +V +
Sbjct: 13384 SQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVD-FLTEENKWQRVMK-SLSL 13441
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNES 1783
+ Y + L E EY FRV A+N G E SE I + DV + +D +
Sbjct: 13442 Q-YSAKDLTEGKEYTFRVSAENENG--EGTPSE-ITVVARDDVVAPD--------LDLKG 13489
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGK-----KWKXXXXXXXXXARI--QKLSINTTYQ 1836
+ + +++N +++++I +GK WK R+ + ++NTT
Sbjct: 13490 LPDLCYLAKENS-----NFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLI 13544
Query: 1837 FRIYARNEIGT------SLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEP 1889
+++ G ++ T + I+I K + P P + E T+ ++TLKW P
Sbjct: 13545 VYDCQKSDAGKYTITLKNVAGTKEGTISI-KVVGKPGIPTGPIKFDEVTAEAMTLKWAPP 13603
Query: 1890 ESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC--IENIKEKDEIIFRISAENTVG 1947
+ +GGS ITNYI+E + W VT +V + + + E E FR+SAEN G
Sbjct: 13604 KDDGGSEITNYILEKRDSVNNKW---VTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYG 13660
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRD 2007
V +S+ + VP P P I V + V +W P+ GG+P+ GY++ ++
Sbjct: 13661 VGEGLKSEPIVARHPFDVPDAPPPP-NIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKE 13719
Query: 2008 VTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+W K + F + L+E Y R+ A N G+ +P EP
Sbjct: 13720 RNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEP 13770
Score = 194 bits (474), Expect = 2e-48
Identities = 212/907 (23%), Positives = 361/907 (39%), Gaps = 56/907 (6%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVK 1249
+E P I+ L L + I + A L V I T +V W K I D + S
Sbjct: 16440 LEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFT 16499
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
+L++ D +YT L ++ T + V V++ P V+ + K +T
Sbjct: 16500 --SLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITW 16557
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCG 1367
+IV + + + + S I +++ + +++ EN G
Sbjct: 16558 EPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYG 16617
Query: 1368 ---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
A + + + P PPGK + ++ +S+++ W +PE+ G S II Y+VE Q +
Sbjct: 16618 IGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHS 16677
Query: 1425 TEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
+W + Q I NL Y FR AVNE SD ++ + + P V
Sbjct: 16678 EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLA--VPIVAKDLVIEPDV 16735
Query: 1485 EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX 1544
+ + + + +D+++ G P+P +TW +DG L K T
Sbjct: 16736 KPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPL---KQTTRINVTDSLDLTTLSI 16792
Query: 1545 XXXYKCIAFNDHGEVETSCVVGIQQK----PVITISNED-IKQKHKVGDEWLVTAVIEGI 1599
+K +D G+ + + QK ++T+ D K K D + +
Sbjct: 16793 KETHK----DDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWN 16848
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTS------VIRIKELKRSHSSKYTIEASNTAGT 1653
PP + N + ++ T + S +++ +LK ++ I A N G
Sbjct: 16849 PPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQ 16908
Query: 1654 S-SVEVTLKVYDKPSK---PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
S ++E V P K P G IS++S+ I+W P+++GG + Y +E+ E +
Sbjct: 16909 SFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERN 16968
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPS 1768
+ W KV + Q L E EY FRV A+N VG +A + SE V + D P
Sbjct: 16969 SILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPG 17028
Query: 1769 XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGKKWKXXXXXXXXXA-R 1825
+ + + W +GGS I Y VE + +G+ K
Sbjct: 17029 ----TPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 17084
Query: 1826 IQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKTLTPP--SQPRNFVVSESTSRSV 1882
+ L+ + Y+FR+ A+N G S P S IT + P S F + +
Sbjct: 17085 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGE 17144
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
T + P ++ K ++ + +I +++ D + + A
Sbjct: 17145 TFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKA-LLIVKDAIRIDGGQYILRA 17203
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
N G ++S V + K P PP P+++ V S +W P DGG+ + Y
Sbjct: 17204 SNVAG----SKSFPVNV-KVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYV 17258
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES-----DE 2057
+ R+ ++ W V +V T + L E + Y+ RI A N+ G+ EPLES
Sbjct: 17259 VEKRETSRLAWTVVAS-EVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKN 17317
Query: 2058 PFKVIPG 2064
PF V+PG
Sbjct: 17318 PF-VLPG 17323
Score = 192 bits (467), Expect = 2e-47
Identities = 176/700 (25%), Positives = 303/700 (43%), Gaps = 46/700 (6%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK---NIT 1434
+D P PP K I + SSI + W +P G S + YVVE ++ + EW +V +
Sbjct: 20667 IDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVR 20726
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNI 1491
T+ + NLK +Y FR AVN + E E V + +++P ++ + ++
Sbjct: 20727 TTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNE--PVQAKDILEAPEIDLDVALRTSV 20784
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXX---XXXXXXXX 1547
+ ED+++ F G P P VTW +D K L A+ + EN
Sbjct: 20785 IAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGK 20844
Query: 1548 YKCIAFNDHGEVETSCV-VGIQQKPVITISNEDIKQKH-KVGDEWLV--TAVIEGIPPPE 1603
Y N GE ++S V V + P + + ++ KH G L+ +I+G P
Sbjct: 20845 YILTIENGVGEPKSSTVSVKVLDTPA---ACQKLQVKHVSRGTVTLLWDPPLIDGGSP-- 20899
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTSS-VEVT-- 1659
+I Y + + +++ + + +S ++ +L + + A N G E T
Sbjct: 20900 IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEP 20959
Query: 1660 LKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADV 1719
+K + P+ P + M++ ++ SV + W P DGG +T+Y +E+ W A +
Sbjct: 20960 VKAAEVPA-PIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTW-SHAGI 21017
Query: 1720 DRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXI 1779
+ E + +L E FRV A+N G S+ + PI +K + P +
Sbjct: 21018 SKTCEIE-VSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQV 21076
Query: 1780 D---NESVYITWFPSEKNGGSPIIDYKVE--IKQEGKKWKXXXXXXXXXARIQKLSINTT 1834
+V++ P K P I + + +E + + I+
Sbjct: 21077 TVRIGHNVHLE-LP-YKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHG 21134
Query: 1835 YQFRIYARNEI-GTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEPESN 1892
++ + N + ++P T IT+G PPS+P+ + E + SV L W PE N
Sbjct: 21135 GKYTVILDNAVCRIAVPIT---VITLG----PPSKPKGPIRFDEIKADSVILSWDVPEDN 21187
Query: 1893 GGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
GG IT Y IE + +W K+V + + N+ + E FR+ AEN GVS P
Sbjct: 21188 GGGEITCYSIEKRETSQTNW-KMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL 21246
Query: 1953 ESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM 2012
S + + +P PP P+ I V S+ + +W P +DGG+ + G+++ ++ +
Sbjct: 21247 VSSIIVAKHQFRIPGPPGKPV-IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSIL 21305
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
W +V ++ ++ L E Y R+YA N GLS P
Sbjct: 21306 WQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSP 21345
Score = 191 bits (466), Expect = 2e-47
Identities = 205/757 (27%), Positives = 301/757 (39%), Gaps = 73/757 (9%)
Query: 1349 KVENTDAG-IYKLRL--ENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWD 1402
KV AG IY+ R+ EN G + V +D PP I +I +S+++ W
Sbjct: 20233 KVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQ 20292
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEV- 1459
+P G S I Y+VE +++ W S N+T+TQ I L NS Y FR +A N V
Sbjct: 20293 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVG 20352
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKN---ITTEPNEDIELTCIFGGVPQPKVTWY 1516
IS+ SE I P ++ PL+ + ++L G P P + WY
Sbjct: 20353 SISNPSEVVGPITCIDS--YGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWY 20410
Query: 1517 RDGKKLKT-AKATYENRXXXXXXXXXXXXXXXYKCIAF---NDHGEVETSCVVGIQQKP- 1571
+D K+L+T A EN C N G + V I KP
Sbjct: 20411 KDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKPG 20470
Query: 1572 -------VITISNEDI----KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
T++ E I + G + ++E V+W LE E
Sbjct: 20471 PPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE---ECI 20527
Query: 1621 ITTKEKTSVIRIKE--LKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
ITT T +I+ E + +KY I + SV V + P P P + + I
Sbjct: 20528 ITT---TKIIKGNEYIFRVRAVNKYGI--GEPLESDSV-VAKNAFVTPGPPGIPEVTK-I 20580
Query: 1679 SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEY 1737
++ S+T+ W P+ DGG +++ Y +EK + + W KV + RD + L EN +Y
Sbjct: 20581 TKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQK-VTGLTENSDY 20639
Query: 1738 MFRVIAQNPVGFSEALESEPIVIKTALDV--PSXXXXXXXXXXIDNESVYITWFPSEKNG 1795
+RV A N G + SEP A D P S+ + W +G
Sbjct: 20640 QYRVCAVNAAG--QGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDG 20697
Query: 1796 GSPIIDYKVEIKQ-EGKKWKXXXXXXXXXAR---IQKLSINTTYQFRIYARNEIGTSLPY 1851
GS + Y VEI+Q E ++W + L Y FR+ A N G P
Sbjct: 20698 GSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPI 20757
Query: 1852 TSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK--TVKG 1909
++ P Q ++ + + V L+ T + G + +I FK
Sbjct: 20758 EMNE----------PVQAKDILEAPEIDLDVALR-TSVIAKAGEDV-QVLIPFKGRPPPT 20805
Query: 1910 KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVP--- 1966
+W K GS + IEN + N G + T V K +TV
Sbjct: 20806 VTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKV 20865
Query: 1967 -SPPTA--PLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
P A L+++ V V W P DGG+P++ Y I RD TK W V +T
Sbjct: 20866 LDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSST 20925
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
F + DLSE + R+ A NEIG+ EP E+ EP K
Sbjct: 20926 -SFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVK 20961
Score = 190 bits (462), Expect = 6e-47
Identities = 204/900 (22%), Positives = 371/900 (41%), Gaps = 65/900 (7%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVK 1249
+E P I L + +++ A+ L V I +V W K + ++ D + + S
Sbjct: 18605 IEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFT 18664
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
L+I T D Y L + T + V V++ P V+ +K+ S VTL
Sbjct: 18665 M--LVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIR-EVKKDS-VTL 18720
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS--KSASLTIKKVENTDAGI---YKLRL 1362
+ P + + + I++K + T+ + + + + T ++EN G +++
Sbjct: 18721 SWEP---PLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLA 18777
Query: 1363 ENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEY 1419
N G A+ V + + P PPG+ ++++ ++ I W++PE+ G S I YVVE
Sbjct: 18778 SNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEM 18837
Query: 1420 QEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
Q + +W + + + +I L Y FR AVNE SD + + ++ +I
Sbjct: 18838 QTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQ-LGVPVIARDIEI 18896
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXX 1538
+ P+VE P + E +++ F G PQ V W +DG+ LK T + +
Sbjct: 18897 K-PSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSL 18955
Query: 1539 X---XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV 1595
Y+ N G + + + +P ++ + +
Sbjct: 18956 SIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRP-------GPPGPIRIDEVSCDSIT 19008
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS------VIRIKELKRSHSSKYTIEASN 1649
I PP + N + KE TT S I+I L ++ + A N
Sbjct: 19009 ISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAEN 19068
Query: 1650 TAGTSSV-EVTLKVYDKPSKPEGPVIMREI---SRESVTIEWKPPLDDGGLELTKYAIEK 1705
G SS E + V + P P GP ++ ++ ++ + W+ P++DGG + Y +E
Sbjct: 19069 RYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEY 19128
Query: 1706 HEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTAL 1764
E + W K + + L+E Y +RV A+N G + +S EP+ +
Sbjct: 19129 KERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPC 19188
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGKKWK-XXXXXXX 1821
D P I +SV + W +GG+ I Y VE ++ +G+ K
Sbjct: 19189 DPPG----QPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQE 19244
Query: 1822 XXARIQKLSINTTYQFRIYARNEI-GTSLPYTSDDKITIGKTLTPPSQPRNFVVSE--ST 1878
+ +L+ + Y+FR++ARN S P S I + + PP + +
Sbjct: 19245 TYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVV 19304
Query: 1879 SRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKE---KDE 1935
LK + P+ ++ + ++ ++ T+I+ S H + +K+ +D
Sbjct: 19305 KAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEII----STDNHTLLTVKDCIRRDT 19360
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
+ ++ +N G T S +V K P PP PLEI + + SWG P+ DGG
Sbjct: 19361 GQYVLTLKNVAG----TRSVAVNC-KVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGG 19415
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
A + Y + R+ + W + + ++ + L + + Y+ R+ N+ G+ EPLES
Sbjct: 19416 ADIDYYIVEKRETSHLAW-TICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLES 19474
Score = 187 bits (456), Expect = 3e-46
Identities = 169/699 (24%), Positives = 289/699 (41%), Gaps = 43/699 (6%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKT 1436
KP PP P +++I SS+ + W +P G I Y+VE ++ EW I KT
Sbjct: 16340 KPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKT 16399
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITT 1493
++ L Y FR A+N+ + + ++ +I E K+++P ++ L K I
Sbjct: 16400 NIEVEKLLEKHEYNFRICAINKAGVGEHADVPG--PIIVEEKLEAPDIDLDLELRKIINI 16457
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCI 1551
+ L G P P+V W + +++ A + Y
Sbjct: 16458 RAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLT 16517
Query: 1552 AFNDHGEVETSCVVGI--QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
N G V + P + + +I K V W + G I K
Sbjct: 16518 LENSSGTKSAFVTVRVLDTPSPPVNLKVTEI-TKDSVSITWEPPLLDGGSKIKNYIVEKR 16576
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT---LKVYDKP 1666
+T K S +I +L+ S + + A N G T +KV + P
Sbjct: 16577 -EATRKSYAAVVTNCHKNS-WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVP 16634
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
+P G + + +++R SV++ W P DGG ++ +Y +E + +W + A V + ++
Sbjct: 16635 -QPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARV-KSLQA- 16691
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
I L + EY+FRV+A N G S+ + PIV K + P + +
Sbjct: 16692 VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLK 16751
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXA-RIQKLSINTTY-----QFRI 1839
I S + P I + ++G K + + LSI T+ Q+ I
Sbjct: 16752 IEVPISGR--PKPTITW----TKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16805
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
N +G S + +T+ K PP P F + ++ S+TL W P GG ITN
Sbjct: 16806 TVANVVGQKT--ASIEIVTLDKP-DPPKGPVKF--DDVSAESITLSWNPPLYTGGCQITN 16860
Query: 1900 YIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
YI++ + W + TV + + + +K E FRI AEN G S ES +
Sbjct: 16861 YIVQKRDTTTTVWDVVSATVARTTLK--VTKLKTGTEYQFRIFAENRYGQSFALESDPIV 16918
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
+ P PP P + ++V+ W P +GG+P++GY++ ++ +W +V K
Sbjct: 16919 AQYPYKEPGPPGTPFATAISKDSMVI-QWHEPVNNGGSPVIGYHLERKERNSILWTKVNK 16977
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
++ +F ++L E Y R+YA N +G+ + ++ E
Sbjct: 16978 TIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSE 17016
Score = 186 bits (453), Expect = 8e-46
Identities = 218/966 (22%), Positives = 386/966 (39%), Gaps = 81/966 (8%)
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLT 1217
G+K ++ ++ EYS + ++ + +E P + L + + + A L
Sbjct: 22913 GQKYSFRVAAVNVKGMSEYSESI--AEIEPVERIEIPDLELADDLKKTVTIRAGASLRLM 22970
Query: 1218 VEIPDETLDV-TWYKK------KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
V + V TW K+ +++I+ TE ++L LI+ K D +YT
Sbjct: 22971 VSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL--------LIVDKVNRYDAGKYTIEA 23022
Query: 1271 LD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
+ K + + V+V + P ++K S ++ + ++ P + VN+ I+
Sbjct: 23023 ENQSGKKSATVLVKVYDTPGPCPSV----KVKEVSRDSVTITWE-IPTIDGGAPVNNYIV 23077
Query: 1329 KKCKHTKPSIDSKSA--SLTIKKVENTDAG-IYKLRL--ENNCG---HADVEMNVTILDK 1380
+K + + + + S T+ ++ G +Y R+ EN G + V + +
Sbjct: 23078 EKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEV 23137
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKT--QT 1438
P P K ++++ S++ + W++P G S + YV+E + T W+ V + T +
Sbjct: 23138 PLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEH 23197
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE---KPLKNITTEP 1495
++ +L Y FR A NE +S+ ET +++ ++ PT++ P K I
Sbjct: 23198 TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV-TVQDLRV-LPTIDLSTMPQKTIHVPA 23255
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCI 1551
+EL G P P +W+ G KL+ ++ T+ Y
Sbjct: 23256 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 23315
Query: 1552 AFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK--N 1609
N G + V I KP I DE T++ PPE+ +
Sbjct: 23316 LKNVTGTTSETIKVIILDKPGPPTGPIKI-------DEIDATSITISWEPPELDGGAPLS 23368
Query: 1610 GNKLENDKEYN-----ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD 1664
G +E + ++ S + L + + + A+N G S + +
Sbjct: 23369 GYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIEC 23428
Query: 1665 K-----PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADV 1719
+ P PE I ++SR+ +T+ W PP DDGG ++T Y +E+ E +RW++V V
Sbjct: 23429 RSSIRIPGPPETLQIF-DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKV 23487
Query: 1720 DRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXX 1778
+ Y L E EY RV A N G + + S+PIV + P
Sbjct: 23488 PVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPI-APPGKPQNPRVTD 23546
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEI-KQEGKKWKXXXXXXXXXAR--IQKLSINTTY 1835
SV + W E GGS + Y +E+ K + +W + L Y
Sbjct: 23547 TTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEY 23606
Query: 1836 QFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESNG 1893
+FR+ A N G P + + + L P + E + ++ T P
Sbjct: 23607 RFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGK 23666
Query: 1894 GSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
PI + E + + ++ ++ + E I+ D + + EN G +
Sbjct: 23667 PFPICKWTKEGQDISKRA---MIATSETHTELVIKEADRGDSGTYDLVLENKCG----KK 23719
Query: 1954 SQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMW 2013
+ +++ + P+ P PLE + V SW P DGGA +LGY + R+V K W
Sbjct: 23720 AVYIKVRVIGS-PNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAW 23778
Query: 2014 MEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEP 2073
+ V ++ L EN Y R+ A N+ G+S+PL+S+EP V P + E P
Sbjct: 23779 YTIDS-RVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEP--VTPKTPLNPPEPP 23835
Query: 2074 GEQTEV 2079
EV
Sbjct: 23836 SNPPEV 23841
Score = 186 bits (452), Expect = 1e-45
Identities = 173/698 (24%), Positives = 291/698 (41%), Gaps = 41/698 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK---NITKT 1436
KP PPG P +L+ SSI+I W++P G S I Y+VE + EW V + T
Sbjct: 15258 KPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKAT 15317
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITT 1493
+I L N Y+ R YA+N + + + K E ++ P +E K +T
Sbjct: 15318 SYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKA--EDRMLPPEIELDADLRKVVTI 15375
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRD-GKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCI 1551
+ L G P P+V W RD G+ L K + + + Y
Sbjct: 15376 RACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILT 15435
Query: 1552 AFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT---AVIEGIPPPEVIWYK 1608
N G V + P +D+K K +T +++G ++ Y
Sbjct: 15436 VENSSGSKSAFVNVRVLDTPG---PPQDLKVKEVTKTSVTLTWDPPLLDG--GSKIKNYI 15490
Query: 1609 NGNKLENDKEYNI--TTKEKTSVIRIKELKRSHSSKYTIEASNTAGT---SSVEVTLKVY 1663
+ K Y+ T KTS ++ +L+ S + + A N G + ++K
Sbjct: 15491 VEKRESTRKAYSTVATNCHKTSW-KVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKAS 15549
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
++P P G + + +++R SV++ W+ P DGG + Y +E +++W A V V
Sbjct: 15550 ERPLPP-GKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVK--V 15606
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
I L + EY FRV AQN G S+ + S P++ K + P+ + E
Sbjct: 15607 TEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGE 15666
Query: 1783 SVYITWFPSEKNGGSPIIDYK--VEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIY 1840
+ + P + +K V +KQ + I+ + +
Sbjct: 15667 DLKVD-VPFIGRPTPAVTWHKDNVPLKQTTRV-NAESTENNSLLTIKDACREDVGHYVVK 15724
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
N G ++ + I + K PP+ P + E T+ S+TL W P+ +GGS I NY
Sbjct: 15725 LTNSAGEAIETLN--VIVLDKP-GPPTGPVK--MDEVTADSITLSWGPPKYDGGSSINNY 15779
Query: 1901 IIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
I+E + +W + TV + + C +K E FRI+AEN G S S+
Sbjct: 15780 IVEKRDTSTTTWQIVSATVARTTIKAC--RLKTGCEYQFRIAAENRYGKSTYLNSEPTVA 15837
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
+ VP PP P+ + + + + W P DGG+ ++GY++ ++ +W+++ K
Sbjct: 15838 QYPFKVPGPPGTPV-VTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKT 15896
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
+ KF L E Y R+ A N +G+ +P + E
Sbjct: 15897 PIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 15934
Score = 184 bits (448), Expect = 3e-45
Identities = 168/704 (23%), Positives = 281/704 (39%), Gaps = 46/704 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP P + + + ++ W +P + G S I+ YVVE Q+ T +W + I +
Sbjct: 11307 PGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCA 11366
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN---ITTE 1494
+ L + YRFR A N V + E E VI + + P VE + IT
Sbjct: 11367 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAE--SVIAKDILHPPEVELDVTCRDVITVR 11424
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT--YEN--RXXXXXXXXXXXXXXXYKC 1550
+ I + G P+P +TW ++GK L K ++ R Y
Sbjct: 11425 VGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYII 11484
Query: 1551 IAFNDHGEVETSCVVGIQQKPVITISNEDIKQ--KHKVGDEWLVTAVIEGIPPPEVIWYK 1608
A N G + S +V + +P N + K W G E+ +
Sbjct: 11485 SAKNSSGHAQGSAIVNVLDRPG-PCQNLKVTNVTKENCTISWENPLDNGG---SEITNFI 11540
Query: 1609 NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG------TSSVEVTLKV 1662
+ N K ++I + T + L ++ + + A N G T + + +
Sbjct: 11541 VEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINP 11600
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
D+P +PE + + + + V ++W+ P DGG Y +E+ ++ W +V
Sbjct: 11601 IDRPGEPEN-LHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIK 11659
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
Y + + EN Y FRV +N G S+ +++E +V+K L P +
Sbjct: 11660 ETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAG 11719
Query: 1783 SVYITWFPSEKNGGSPII----DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFR 1838
I + P + D + K + K + ++
Sbjct: 11720 DT-IRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 11778
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPIT 1898
+ A N G+ + Y + + L P RN + + +S T+ W PE +GG I
Sbjct: 11779 VTATNTAGSFVAYATVN------VLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQ 11832
Query: 1899 NYIIEFKTVKGKSWTK----IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
NYI+E K W+ ++T G +V + E +E IFR+ AEN +G PTES
Sbjct: 11833 NYILEKCETKRMVWSTYSATVLTPGTTV-----TRLIEGNEYIFRVRAENKIGTGPPTES 11887
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
+ V + P P P E+ V + W PE+DGG + GY + ++ T W+
Sbjct: 11888 KPVIAKTKYDKPGRPDPP-EVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWV 11946
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
V K + + +++L +H Y R+ A NEIG+ EP P
Sbjct: 11947 PVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRP 11990
Score = 184 bits (448), Expect = 3e-45
Identities = 168/697 (24%), Positives = 286/697 (41%), Gaps = 35/697 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK---NITKT 1436
KP PP +I++ +SI + W +P G S I+ YVVE + D EW V + T
Sbjct: 17422 KPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVT 17481
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE---KPLKNITT 1493
+ I L + Y+ R A+N+V + +A+ K E K+++P ++ + K I
Sbjct: 17482 RFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVK--PEDKLEAPELDLDSELRKGIVV 17539
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKC 1550
+ F G P P++TW R+ + T K E N Y
Sbjct: 17540 RAGGSARIHIPFKGRPTPEITWSREEGEF-TDKVQIEKGVNYTQLSIDNCDRNDAGKYIL 17598
Query: 1551 IAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLV--TAVIEGIPPPEVIWYK 1608
N G V + P N +K+ K +LV +I+G +V Y
Sbjct: 17599 KLENSSGSKSAFVTVKVLDTPGPP-QNLAVKEVRK-DSAFLVWEPPIIDG--GAKVKNYV 17654
Query: 1609 NGNKLENDKEY-NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD--K 1665
+ K Y N+++K + +++ L + + A N G T+ +
Sbjct: 17655 IDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAE 17714
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P P G V + ++S+ S ++ W+ P DGG + Y +E +W VA+ V
Sbjct: 17715 PPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAE--SKVCN 17772
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEA-LESEPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
+ L+ EY FRV A N G S+ + P++ K PS E +
Sbjct: 17773 AVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDL 17832
Query: 1785 YITWFPSEKNGGSPIIDYKV-EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
I P I K E ++ + I++ + + ++ + A N
Sbjct: 17833 KIE-IPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATN 17891
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
GT+ T + + + + PP P F E ++ V + W P GG I+NYI+E
Sbjct: 17892 SAGTA---TENLSVIVLEKPGPPVGPVRF--DEVSADFVVISWEPPAYTGGCQISNYIVE 17946
Query: 1904 FKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
+ +W + TV + + I +K E FRI AEN G S P +S++V ++
Sbjct: 17947 KRDTTTTTWHMVSATVARTTIK--ITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYP 18004
Query: 1963 ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
P PP P + + + ++ W P DGG ++GY++ ++ +W+++ K +
Sbjct: 18005 FKEPGPPGTPF-VTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQ 18063
Query: 2023 TLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPF 2059
KF L E Y ++ A N +G+ +P + E F
Sbjct: 18064 DTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF 18100
Score = 184 bits (447), Expect = 4e-45
Identities = 107/367 (29%), Positives = 174/367 (47%), Gaps = 6/367 (1%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G+ + A+++G P P V W+K+G ++E IT ++ + +++ R H YT
Sbjct: 21474 KSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYT 21533
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+EA N +G++ E+ +KV D P K GP+ I+ E +T+ W PL+DG +T Y IE
Sbjct: 21534 VEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE 21593
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTAL 1764
K E W + D + ++Y KL EY FRV A N G L+S+P+V +
Sbjct: 21594 KRETSRLAWALIED-KCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQY 21652
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKW-KXXXXXXXX 1822
VP I S+ +TW E +GGS I Y +E ++ + +W K
Sbjct: 21653 TVPD-APGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPIS 21711
Query: 1823 XAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSR 1880
R + L+ Y+F + A N G I + + PP P V++++
Sbjct: 21712 ETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKT 21771
Query: 1881 SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
+V+L+W++P +GG I YIIE W K+ + + +++ +E FR+
Sbjct: 21772 TVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRV 21831
Query: 1941 SAENTVG 1947
SA N G
Sbjct: 21832 SAINGAG 21838
Score = 183 bits (446), Expect = 5e-45
Identities = 178/727 (24%), Positives = 290/727 (39%), Gaps = 68/727 (9%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV----KNITKT 1436
P PP P + + SSI++ W P G S I Y+VE QE TT+W V K IT
Sbjct: 9208 PGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTC 9267
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEP 1495
+ + NLK YRFR AVNE S+ S+TT + ++ ++ + +
Sbjct: 9268 ECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKA 9327
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------------ATYENRXXXXXXXXXXX 1543
I + + G P PK +W DGK K K T EN
Sbjct: 9328 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRS 9387
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPP 1602
Y A N G+ +C V + P +D+K G L + +
Sbjct: 9388 HTGKYSITAKNKAGQKTANCRVKVMDVPG---PPKDLKVSDITRGSCRLSWKMPDDDGGD 9444
Query: 1603 EVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
+ Y + + K + + ++ + +L + + A N G T++
Sbjct: 9445 RIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQ 9504
Query: 1662 ---VYDKPSKPEGPVIMRE--ISRESVTIEWKPPLDDGGLELTKYAIE--KHEPDNNR-- 1712
D P+ P+ ++ I++ +V + WKPP +DGG +T Y +E +P +
Sbjct: 9505 RTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKE 9564
Query: 1713 -WIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXX 1771
W + D + + ++ L E EY FRV A N G S+ + D+P
Sbjct: 9565 AWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSID 9624
Query: 1772 XXXXXXXIDNESVYI------------TWF---PSEKNGGSPIIDYKVEIKQEGKKWKXX 1816
+ +V I TWF P + + P++ Y + +
Sbjct: 9625 LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVL-YDTHVNK-------L 9676
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE 1876
I + + T + I A N +GT+ + + ++ + PP P F E
Sbjct: 9677 VVDDTCTLVIPQSRRSDTGLYTITAVNNLGTA---SKEMRLNVLGRPGPPVGPIKF---E 9730
Query: 1877 STSRS-VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
S S +TL W P+ +GGS ITNY+IE + K+W + + + I + E E
Sbjct: 9731 SVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKEC-TYTIPKLLEGHE 9789
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
+FRI A+N G+ P +S+ +VP P P + V N + +W PE+DGG
Sbjct: 9790 YVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPT-VSSVTRNSMTVNWEEPEYDGG 9848
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTL----KFNIRDLSENHTYMIRIYARNEIGLSE 2051
+P+ GY + ++D T W V + + + + + L E Y R+YA N G+
Sbjct: 9849 SPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGP 9908
Query: 2052 PLESDEP 2058
+P
Sbjct: 9909 ASLPSDP 9915
Score = 182 bits (443), Expect = 1e-44
Identities = 246/1098 (22%), Positives = 447/1098 (40%), Gaps = 107/1098 (9%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
GI F + Q V EG C L + + + W ++ + ++ E H
Sbjct: 5074 GIRLKFMSPLEDQTVKEGETATFVCEL-SHEKMHVVWFKNDAKLHTSRTVLISSEGKTHK 5132
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ +E T ++ + L ++K E +P ++ V + E
Sbjct: 5133 L----------EMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKDE 5182
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKA 807
+ L +V + + W K+ + + P K+DG I +K +KD+G Y
Sbjct: 5183 -ITLKCEV--SKDVPVKWFKDGEEIVPSPKYSIKADG-LRRILKIKKADLKDKGEYVCDC 5238
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
G +T A +TVE + E PL+ E+ V E ++ P W
Sbjct: 5239 ----GTDKTKANVTVEARLIK-VEKPLY---GVEVFVGETAHFEIELS---EPDVHGQWK 5287
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ ++ S DG+ L++ N + +G+ A+N+ KS+ A + +
Sbjct: 5288 LKGQPLTASPDCEIIEDGKKHILILHNCQLGM-TGEVSFQAANA--KSA--ANLKVKELP 5342
Query: 928 VTFVKHLQ--KSYETEEGKTVILECQTSHTVST-KWYHNKKEISGMDHREIIQEGRXXXX 984
+ F+ L K +E +E K EC+ S T +W +EI+G D E+I++G
Sbjct: 5343 LIFITPLSDVKVFEKDEAK---FECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSM 5399
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D +D+ TS L+++ +F+ L+D KEK+ A+ VE++ +
Sbjct: 5400 VIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELSHDN 5459
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
V W ++ + + ++ + G + ++ S+ D + S A++TV+E
Sbjct: 5460 IRVKWFKNDQRLHTTRS-VSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLE 5518
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P +LQ+ + ++ + E++K DA V+WFKDG EI+ S + + DGKK+ L
Sbjct: 5519 GDPYFTGKLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLI 5578
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G+Y+C+ G K + L +E+ I L ++ T + T EI ++
Sbjct: 5579 LKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFET-EISEDD 5637
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + T + + K +L++ C D + KS+ L+V+
Sbjct: 5638 IHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVK-- 5695
Query: 1285 EFPPKIVDYER---EYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
P+++ R + + G T + Y+ P EW + K ++ P +
Sbjct: 5696 ---PRVIGLLRPLKDVTVTAGETATFDCELSYEDIPV---EWYLKGKKLEPSDKVVPRSE 5749
Query: 1340 SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINI 1399
K +LT++ V+ DAG +L ++ HA N+ + + P KP LE
Sbjct: 5750 GKVHTLTLRDVKLEDAGEVQLTAKDFKTHA----NLFVKEPPVEFTKP--LE-------- 5795
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
D+ G + ++ V +E +W KN T+ S + + + R R +++
Sbjct: 5796 --DQTVEEGATAVLECEVS-RENAKVKWF--KNGTEILKS-KKYEIVADGRVRKLVIHDC 5849
Query: 1460 ---DISDASETTEYYKVIKETKIQSPTVE--KPLKNITTEPNEDIELTCIFGGVPQPKVT 1514
DI + + +K + P VE +PL ++ E C KV
Sbjct: 5850 TPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSR-ENAKVK 5908
Query: 1515 WYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV-GIQQKPVI 1573
W++DG ++K K Y+ KC+ +D E E SC V + ++
Sbjct: 5909 WFKDGAEIKKGK-KYD-----IISKGAVRILVINKCL-LDD--EAEYSCEVRTARTSGML 5959
Query: 1574 TISNED-IKQKHKVGDEWLVTAVIEGI-----PPPEVIWYKNGNKLENDKEYNITTKEKT 1627
T+ E+ + K+ E T I+ + P EVIWYK ++ Y I T+ +
Sbjct: 5960 TVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRK 6019
Query: 1628 SVIRIKELKRSHSSKYT--IEASNTAGTSSV-EVTLKVYDKPS-----KPEGPVIMREIS 1679
++ I+ + Y + +S T G V E+ + KP + E + IS
Sbjct: 6020 RILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSIS 6079
Query: 1680 RESVTIEWKPPLDDGGLE 1697
+ES ++WK DD LE
Sbjct: 6080 KESFPVQWK--RDDKTLE 6095
Score = 181 bits (440), Expect = 3e-44
Identities = 176/746 (23%), Positives = 300/746 (40%), Gaps = 44/746 (5%)
Query: 795 KKVKDEGVYTLKA---ENSEGIAETSAV-ITVEEPTEENAEP----PLFINRFQEITVKE 846
+K KDE ++ K E + +AE + I +P + P P R Q TV +
Sbjct: 1986 RKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQ 2045
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENI-ELVITNVDSEIDSGDYK 905
RV P P WY+N I S+ I + +N+ ELVI +V +E DS
Sbjct: 2046 GSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAE-DSASIM 2104
Query: 906 CVASNSAGKSSHGARVTIDVEK-VTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHN 963
A N AG++S A + + ++ +TF + LQ E+ EC+TS V KWY +
Sbjct: 2105 VKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKD 2164
Query: 964 KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE---TSTMLVVKETIPEFI 1020
E+ D + + + D C++ + E T+ L+V+ + EF+
Sbjct: 2165 GMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFV 2224
Query: 1021 RKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTS 1080
++LQD EV E LE ++ E + W + +K KY R + L +++ +
Sbjct: 2225 KELQDIEVPESYSGELECIVSPENIEGKWYHNDVELK-SNGKYTITSRRGRQNLTVKDVT 2283
Query: 1081 VHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWF 1140
D+GEYS ++ + T ++ + P I+ L +QKV +G+ E++++ W
Sbjct: 2284 KEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWM 2343
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL 1200
KDG E+Q S+ + + ID + L I D +DAG YS + + V S++
Sbjct: 2344 KDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVIT 2403
Query: 1201 RLPEFILVPANTDAYL--TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
L + + V T A L V +PD T V WY I+ ++ I K+ L+I +
Sbjct: 2404 PLKD-VNVIEGTKAVLECKVSVPDVT-SVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRT 2461
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
D+ Y ++ ++ L VE + KI+ R+ +V V+ + +
Sbjct: 2462 HASDEGPYKLIVGRVETNCNLSVEKI----KIIRGLRDLTCTETQNVVFEVEL-SHSGID 2516
Query: 1319 DEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL 1378
W K IK K K LT+ + D G Y N + + +
Sbjct: 2517 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAGGAI 2576
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT 1438
KP + E + P++ G EW+
Sbjct: 2577 SKPLT--DQTVAESQEAVFECEVANPDSKG-----------------EWLRDGKHLPLTN 2617
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
+I++ R A DI + + K + K+++ ++K LKN+T +D
Sbjct: 2618 NIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2677
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKT 1524
T V W ++G L++
Sbjct: 2678 AVFTVELTHPNVKGVQWIKNGVVLES 2703
Score = 179 bits (436), Expect = 9e-44
Identities = 174/747 (23%), Positives = 309/747 (41%), Gaps = 47/747 (6%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
SK Q V E + + EC VA P+ WL G+ + NI ESD H ++
Sbjct: 2577 SKPLTDQTVAESQEAVFECE-VANPDSKGEWLRDGKHLPLTNNIRS--ESDGHKRRLIIA 2633
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
T + E TY V + + V KIK + LK++ V + + + +
Sbjct: 2634 ATKLDDIGEYTYKVATSKTSAKLKVEAV-KIK----------KTLKNLTVTETQDAVFTV 2682
Query: 757 QVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
++ + W KN +++ G +S+ I K + DE VY + G
Sbjct: 2683 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI-KNCAIVDESVYGFRL----GR 2737
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
SA + VE I + +++T E T+ V+ + VP + W+ N I
Sbjct: 2738 LGASARLHVETVK--------IIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKNVEI 2788
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
PS+ + + +L++ N+ S D+G+Y V G+ A++ ++ +T
Sbjct: 2789 KPSDKHRLVSERKVHKLMLQNI-SPSDAGEYTAVV----GQLECKAKLFVETLHIT---K 2840
Query: 934 LQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXX 992
K+ E E KT EC+ SH V + W N EI + +I+ +G+
Sbjct: 2841 TMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE 2900
Query: 993 DVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERD 1052
D + + + S L V + L+D +EKD EV +N E W ++
Sbjct: 2901 DSAEYTFVCGNDQVSATLTVTPIM--ITSMLKDINAEEKDTITFEVTVNYEGISYKWLKN 2958
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR 1112
G IK +K + L IRN D +Y+ + + TA + V E
Sbjct: 2959 GVEIK-STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKH 3017
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+++ KV + +A FE E+++ D V+W KD E+Q ++ I++ + +L I + D
Sbjct: 3018 IKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3077
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
AG+Y+ G + TA L VE + + + + V A + E+ ++ +D WYK
Sbjct: 3078 AGKYTVVAGGNVSTAKLFVEGRDVRIR-SIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3136
Query: 1233 KSVI--EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
I + E+ + + + + I + + D EYT V +S+ L V E PP++
Sbjct: 3137 GIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPE-PPQV 3195
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
+ + ++ G PQP W +++ K D + +L + +
Sbjct: 3196 LQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEA 3255
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTI 1377
DA +Y +N+ G A ++++
Sbjct: 3256 FPEDAAVYTCEAKNDYGVATTSASLSV 3282
Score = 178 bits (434), Expect = 2e-43
Identities = 156/561 (27%), Positives = 249/561 (44%), Gaps = 26/561 (4%)
Query: 804 TLKAENSEGIAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
T+K E E S VI ++ T + P + + V E ++L +V+
Sbjct: 2278 TVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLES 2337
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
V + W ++ + + PS+ + D ++ L+I ++ E D+G+Y + G S+ G
Sbjct: 2338 VEGV-WMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKE-DAGNYSFTIP-ALGLSTSGRV 2394
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQE 978
V+ +T +K + EG +LEC+ S S KWY N ++I D + I +
Sbjct: 2395 SVYSVDVITPLKDVN----VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVK 2450
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
G D G K IV ET+ L V++ + IR L+D E + EV
Sbjct: 2451 GTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI--KIIRGLRDLTCTETQNVVFEV 2508
Query: 1039 EINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA 1098
E++ DV+W + IKP +KY E G I KL + N DEG+Y+ + +
Sbjct: 2509 ELSHSGIDVLWNFKDKEIKPS-SKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSG 2567
Query: 1099 EVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDG 1158
++TV I L +Q V + +A FE E+ D+ W +DG + +N+I+ DG
Sbjct: 2568 KLTVAG--GAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDG 2625
Query: 1159 KKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
K++L I LDD GEY+ +V SK +A L VE I TL+ + V DA TV
Sbjct: 2626 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLK---NLTVTETQDAVFTV 2682
Query: 1219 EIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
E+ + V W K V+E EK+ + +L I+ C D+ Y L ++
Sbjct: 2683 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASA 2742
Query: 1278 KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
+L VE V KI+ ++ + V V P + N +I KH S
Sbjct: 2743 RLHVETV----KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKHRLVS 2798
Query: 1338 IDSKSASLTIKKVENTDAGIY 1358
+ K L ++ + +DAG Y
Sbjct: 2799 -ERKVHKLMLQNISPSDAGEY 2818
Score = 178 bits (434), Expect = 2e-43
Identities = 153/697 (21%), Positives = 291/697 (41%), Gaps = 36/697 (5%)
Query: 1382 SPPGKPNILEIDSSS---INICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
+PPG P ++++ +S +++ W +P G II Y++E + D +W ++ + KT
Sbjct: 21755 NPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKT 21814
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI-TTEP 1495
+ ++ +L+ Y+FR A+N D+ E T K + ++ K
Sbjct: 21815 RYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRA 21874
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAF 1553
I L + G P P W + L T ++ Y
Sbjct: 21875 GASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVE 21934
Query: 1554 NDHGEVETSCVVGIQQKPVIT--ISNEDIKQKHKVGDEWLV--TAVIEGIPPPEVIWYKN 1609
N+ G + V + P I+ +D+ + G L+ +++G + Y
Sbjct: 21935 NNSGSKSITFTVKVLDTPGPPGPITFKDVTR----GSATLMWDAPLLDG--GARIHHYVV 21988
Query: 1610 GNKLENDKEYNITTKEKT-SVIRIKELKRSHSSKYTIEASNTAGTSS---VEVTLKVYDK 1665
+ + + + + +++ T + ++ +L + + A N G + + ++
Sbjct: 21989 EKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQ 22048
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P+ P ++ + S+ S + W P DGG +T Y +E + ++ W++ + T
Sbjct: 22049 PAPPRRLDVV-DTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQ--LT 22105
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
+ +++L E EY FRV A+N G+SE E+ ++IK P+ I ++
Sbjct: 22106 FTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAG 22165
Query: 1785 YITWFPSEKNGG-SPIIDYKVEIKQ--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+G +P + +K+E + E + ++ + ++ +
Sbjct: 22166 SPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTL 22225
Query: 1842 RNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
N G S + IG+ P + P VS ++ S L W EP+ GG+ ITNYI
Sbjct: 22226 ENTAGVKT--FSVTVVVIGRP-GPVTGP--IEVSSVSAESCVLSWGEPKDGGGTEITNYI 22280
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
+E + +W ++V + + ++ + E FR+S+EN GVS P ES + E
Sbjct: 22281 VEKRESGTTAW-QLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEH 22339
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
PS PT P E+ V +N + W P DGG+ ++GY + ++ +W++ KV
Sbjct: 22340 PFVPPSAPTRP-EVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPC 22398
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ + L E Y R YA N G+S+ E+ P
Sbjct: 22399 LECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRP 22435
Score = 178 bits (433), Expect = 2e-43
Identities = 212/908 (23%), Positives = 369/908 (40%), Gaps = 68/908 (7%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTW------YKKKSVIEDTEKFTLIS 1246
P L ++V A + V I +VTW K ++ IE+TE FTL
Sbjct: 14277 PDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTL-- 14334
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSD 1304
LII +C D ++ + + K + + V V++ P +++ R I + S
Sbjct: 14335 ------LIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNL-RPTDITKDS- 14386
Query: 1305 VTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL--TIKKVENTDAG---IYK 1359
VTL D P + + + I++K + T+ S + + KV G ++
Sbjct: 14387 VTLHWD---LPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFR 14443
Query: 1360 LRLENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
+ EN G + V + PSPP NI++I S++++ W +P++ G S I YV
Sbjct: 14444 VMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYV 14503
Query: 1417 VEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+E Q + +W + + + ++NL Y F+ AVN S E+ ++KE
Sbjct: 14504 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPV--IVKE 14561
Query: 1477 TKIQSPTVEKPL--KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRX 1533
+ + + K + + ++I++ G P+P VTW + + LK T + +E
Sbjct: 14562 QTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTA 14621
Query: 1534 XXXXXXX---XXXXXXXYKCIAFN---DHGEVETSCVVGIQQKPVITISNEDIKQKHKVG 1587
Y A N + G+V T V I P I +++ V
Sbjct: 14622 TSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDF-VT 14680
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
W G+P + + ++ + T + + L ++ ++A
Sbjct: 14681 FSWDPPENDGGVPISNYV--VEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKA 14738
Query: 1648 SNTAG-----TSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYA 1702
N G TS+ V + P P P + ++++S+TI W PL DGG + Y
Sbjct: 14739 QNRYGVGPGITSACIVANYPFKVPGPPGTPQV-TAVTKDSMTISWHEPLSDGGSPILGYH 14797
Query: 1703 IEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIK 1761
+E+ E + W V+ + L + Y FRVIA+N G S+ + SEP++
Sbjct: 14798 VERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLAL 14857
Query: 1762 TALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGKKWKXXXXX 1819
+D P I +V + W E GG I Y VE + G+ K
Sbjct: 14858 DPIDPPG----KPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSN 14913
Query: 1820 XXXXA-RIQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKTLTPPSQPRNFVVSES 1877
+ L+ + Y+FR+ A+N G S P D IT + P + ++
Sbjct: 14914 ILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDT 14973
Query: 1878 TSRSVTLKW-TEPESNGGSPIT-NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
+ E + +G P T + + K ++G + +I S + ++ +D
Sbjct: 14974 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN-LVNKDSTRRDS 15032
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
+ ++A N G + + V L++ P PP PL + V S + SW P DGG
Sbjct: 15033 GAYTLTATNPGGFAKHIFNVKV-LDR----PGPPEGPLAVTEVTSEKCVLSWFPPLDDGG 15087
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
A + Y + R+ ++ W V +V K + L + + Y+ R+ A N+ G+ EPLES
Sbjct: 15088 AKIDHYIVQKRETSRLAWTNVAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLES 15146
Query: 2056 DEPFKVIP 2063
+ V P
Sbjct: 15147 EPVLAVNP 15154
Score = 177 bits (432), Expect = 3e-43
Identities = 242/1060 (22%), Positives = 407/1060 (38%), Gaps = 87/1060 (8%)
Query: 645 VDEGSDILLECRLVAIPE-PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG+ +LEC+ V++P+ + W E+I PD+ + ++ L I
Sbjct: 2410 VIEGTKAVLECK-VSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQR----LVINRTHAS 2464
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
EG Y ++ E +L + KIK +I L+ + + ++V+ ++ +
Sbjct: 2465 DEGPYKLIVGRVETNCNLSVE-KIK--------IIRGLRDLTCTETQNVVFEVEL-SHSG 2514
Query: 764 PTITWC---KNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+ W K KP ++ G + +T+L K DEG YT A E I TS +
Sbjct: 2515 IDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMK-DDEGKYTFYA--GENI--TSGKL 2569
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV PL + TV E V NP W R+ + + + I
Sbjct: 2570 TVAGGA---ISKPL-----TDQTVAESQEAVFECEVA-NPDSKGEWLRDGKHLPLTNNIR 2620
Query: 881 QNFDGENIELVI--TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
DG L+I T +D +I YK S ++ K + VE V K L+
Sbjct: 2621 SESDGHKRRLIIAATKLD-DIGEYTYKVATSKTSAK--------LKVEAVKIKKTLKNLT 2671
Query: 939 ETEEGKTVI-LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
TE V +E + +W N + + I +G D V
Sbjct: 2672 VTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVY 2731
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
+ S L V ET+ + I+K +D E EV ++ +T V W IK
Sbjct: 2732 GFRLGRLGASARLHV-ETV-KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIK 2789
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
P +K+ + KL ++N S D GEY+ ++ C A++ V L I ++N +
Sbjct: 2790 PS-DKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL--HITKTMKNIE 2846
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + A+FE E++ + W K+G EI+ S ++ + GK +L I + +D+ EY+
Sbjct: 2847 VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT 2906
Query: 1178 CEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE 1237
GN + +A LTV I T L + +T + V + E + W K I+
Sbjct: 2907 FVCGNDQVSATLTVTP--IMITSMLKDINAEEKDTITF-EVTVNYEGISYKWLKNGVEIK 2963
Query: 1238 DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV--VEFPPKIVDYER 1295
T+K + + +L IR D +YT V A ST L VE +EF I D +
Sbjct: 2964 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDI-K 3022
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDA 1355
KR + + P +W+ + + ++ K + L I +DA
Sbjct: 3023 VLEKKRAMFECEVSE----PDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 3078
Query: 1356 GIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
G Y + N A + + + S + ++E + + +E + +
Sbjct: 3079 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 3138
Query: 1416 VVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+ +Q + +++ + I + S Y F A + S T Y
Sbjct: 3139 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGR-------NRSSVTLYVNAP- 3190
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENR 1532
+ P V + L+ +T + + + G PQPK++WY++ + L T K ++ +
Sbjct: 3191 ----EPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQ 3246
Query: 1533 XXXXXXXXXX-XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A ND+G TS + ++ V++ E +
Sbjct: 3247 EYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQ 3306
Query: 1592 VTAVIEGIPPP----------EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
T EG P +V WY K++ + + +T E T + I E
Sbjct: 3307 DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 3366
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRE 1681
YT ASN G S L + + P I +EI E
Sbjct: 3367 TYTFVASNAVGQVSSTANLSL-EAPESILHERIEQEIEME 3405
Score = 176 bits (429), Expect = 6e-43
Identities = 155/678 (22%), Positives = 278/678 (41%), Gaps = 27/678 (3%)
Query: 712 AVNREGEASLPIVLKIK---TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
A+ EG+ ++P K + E P++ E ++S V QG +VVG P P W
Sbjct: 2006 ALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEW 2065
Query: 769 CKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
KN ++ + D +++ +D +KA N G + A + V+
Sbjct: 2066 YKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA- 2124
Query: 826 TEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
+ F Q++ KEK T+ T P + WY++ + + + D
Sbjct: 2125 ----KQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDR 2180
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+ L I +D+ D+ DY CV + A++ ++ V FVK LQ E E +
Sbjct: 2181 KVHFLSILTIDTS-DAEDYSCVLVEDENVKT-TAKLIVEGAVVEFVKELQ-DIEVPESYS 2237
Query: 946 VILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ 1004
LEC S + KWYHN E+ I D G ++ +
Sbjct: 2238 GELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK 2297
Query: 1005 ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY- 1063
+T+ L +K ++ L D +V E D+ LEV+++ E+ + VW +DG+ ++P +
Sbjct: 2298 KTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHI 2357
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
+K+ H+ L I + + D G YS + + V ++IT L++ V +G K
Sbjct: 2358 VIDKQSHM--LLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTK 2415
Query: 1124 ATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
A E +++ D V+W+ + +I+ + +Q + G KQ+L I D G Y VG
Sbjct: 2416 AVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGR 2475
Query: 1183 SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKF 1242
+ L+VE+ I LR + + VE+ +DV W K I+ + K+
Sbjct: 2476 VETNCNLSVEKIKIIRGLR---DLTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKY 2532
Query: 1243 TLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
+ + K L + +DD+ +YT + ++ KL V + D +
Sbjct: 2533 KIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAGGAISKPLTD----QTVAES 2588
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
+ + A P EW+ + K + + + D L I + D G Y ++
Sbjct: 2589 QEAVFECEV-ANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKV 2647
Query: 1363 ENNCGHADVEMNVTILDK 1380
+ A +++ + K
Sbjct: 2648 ATSKTSAKLKVEAVKIKK 2665
Score = 174 bits (424), Expect = 3e-42
Identities = 197/865 (22%), Positives = 337/865 (38%), Gaps = 48/865 (5%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVV 1284
VTW KK+ T+ ++ V + L IR +D Y+ + + T +KV V+
Sbjct: 10753 VTW-KKEDRDAPTKARIDVTPVGSK-LEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVL 10810
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
+ P D E K +T ++V + + + + S SK S
Sbjct: 10811 DKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKS 10870
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL---EIDSSSIN 1398
K + + ++++ EN G + + LD PPG P L ++D + ++
Sbjct: 10871 HFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVS 10930
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
+ W++P+ G S I Y+VEYQE T +WI K +T + + L+ +YRFR A N
Sbjct: 10931 LVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENI 10990
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVE---KPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
V + +TT + + K+ P+VE K ++ + + + I GVP P W
Sbjct: 10991 VGLG-LPDTT--IPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKW 11047
Query: 1516 YRDGKKLKTAK-ATYENRXXXXXXXX---XXXXXXXYKCIAFNDHGEVETS---CVVGIQ 1568
DG ++KT + T E Y+ N G + V+ +
Sbjct: 11048 TTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVP 11107
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I+ D+ +H + W G P I K + D +++ +
Sbjct: 11108 GPPTGPINILDVTPEH-MTISWQPPKDDGGSPVINYIVEKQDTR--KDTWGVVSSGSSKT 11164
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGT----SSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
++I L++ + + A N G S K P P G ++ +I+ + T
Sbjct: 11165 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 11224
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
+ W P DGG +T Y +E+ E +W++V + + L E Y FRV A+
Sbjct: 11225 VSWTLPKSDGGSPITGYYMERREV-TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAE 11283
Query: 1745 NPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G S+ + S+PI + P E+ + W +GGSPI+ Y
Sbjct: 11284 NLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDK-SRETADLVWTKPLSDGGSPILGYV 11342
Query: 1804 VEIKQEG-KKWKXXXXXXXX---XARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
VE ++ G +W R+ L Y+FRI A N +G P + +
Sbjct: 11343 VECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIA 11402
Query: 1860 GKTLTPPSQPRNFVVSESTSRSV--TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT 1917
L PP + + + V T++ P + E K + + ++
Sbjct: 11403 KDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQ 11462
Query: 1918 VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM 1977
V E I+ D + ISA+N+ G +Q + P P L++
Sbjct: 11463 DLPRV-ELQIKEAVRADHGKYIISAKNSSG-----HAQGSAIVNVLDRPG-PCQNLKVTN 11515
Query: 1978 VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTY 2037
V SW P +GG+ + + + R + W V DV T + +L N+ Y
Sbjct: 11516 VTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVAS-DV-TKRLIKANLLANNEY 11573
Query: 2038 MIRIYARNEIGLSEPLESDEPFKVI 2062
R+ A N++G+ +E+ P I
Sbjct: 11574 YFRVCAENKVGVGPTIETKTPILAI 11598
Score = 171 bits (415), Expect = 3e-41
Identities = 164/708 (23%), Positives = 296/708 (41%), Gaps = 36/708 (5%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKT 1436
+D P PPGKP + ++ +S+ + W +PE+ G + I YV+E + T EW+ V + + T
Sbjct: 7484 IDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTT 7543
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNIT-TEP 1495
Q + L Y FR AVN+ S+ SE ++ V+ K+ P+ + L+ I T+
Sbjct: 7544 QHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSD--PVLCREKLYPPSPPRWLEVINITKN 7601
Query: 1496 NEDIELTCIF--GGVPQPK-VTWYRDGKKL------KTAKATYENRXXXXXXXXXXXXXX 1546
D++ T GG P + RD ++ T K T
Sbjct: 7602 TADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVA 7661
Query: 1547 XYKCIAFNDHGEVETSCVVG---IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE 1603
I +D+ E+E S + P ++ D+ ++H V +W G P
Sbjct: 7662 AENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRH-VDLKWEPPKNDGGRPIQR 7720
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT---SSVEVTL 1660
+ K +L T R+ ++ ++ + A N AG S L
Sbjct: 7721 YVIEKK-ERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEIL 7779
Query: 1661 KVYDKPSKPEGPVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
+ D S P P+ + + R+ + I WKPP +GG + Y +E +W++V
Sbjct: 7780 SIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNS 7839
Query: 1719 VD-RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXX 1776
+D++ + + + EY+ RV A N +G SE E SE +V K P+
Sbjct: 7840 RPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDI 7899
Query: 1777 XXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQ-KLSINTTY 1835
I+ E + I P + P + + + K+ + A ++ S+
Sbjct: 7900 IVIEGEKLSIP-VPF-RAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADA 7957
Query: 1836 Q-FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
+ I N++G++ T+ + K + P ++ S+ T S L W PE +GG
Sbjct: 7958 GIYTITLENKLGSA---TASINV---KVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGG 8011
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
+PI +Y++E + +++ +++ G + ++++ E FR+ A N VG E
Sbjct: 8012 TPILHYVLERREAGRRTYIPVMS-GENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIEL 8070
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
++ + + P P +E+ + + +W P +DGG+ ++GY I + W
Sbjct: 8071 KNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWK 8130
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVI 2062
+ V L + + L E Y R+ A N G+SEP + P K +
Sbjct: 8131 RCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAV 8178
Score = 166 bits (404), Expect = 7e-40
Identities = 246/1096 (22%), Positives = 440/1096 (40%), Gaps = 86/1096 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P ++ ++Q V +GSD R+V P+P+ W G +I + I D C
Sbjct: 2032 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPED--NVCE 2089
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
L I +V + V A+N GE S L ++ K+ + L+ ++ ++ +++
Sbjct: 2090 -LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA--KQLITFTQELQDVVAKEKDTMA 2146
Query: 754 LSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
P + W K+ V SD H ++IL D Y+
Sbjct: 2147 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSIL-TIDTSDAEDYSCVLVED 2205
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
E + +T+A + VE E F+ Q+I V E + +L V+ + WY N+
Sbjct: 2206 ENV-KTTAKLIVEGAVVE------FVKELQDIEVPESYSGELECIVSPENIEG-KWYHND 2257
Query: 871 -EIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
E+ S + TIT +N L + +V E D G+Y V GK + ++ + +
Sbjct: 2258 VELKSNGKYTITSRRGRQN--LTVKDVTKE-DQGEYSFVID---GKKT-TCKLKMKPRPI 2310
Query: 929 TFVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
++ L + EG V LE + S +V W + +E+ D I+ + +
Sbjct: 2311 AILQGL-SDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIE 2369
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
D G + ST V + I L+D V E A+LE +++ +
Sbjct: 2370 DMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTS 2429
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELP 1106
V W + E IKP ++ +G ++L I T DEG Y I+ ++V ++
Sbjct: 2430 VKWYLNDEQIKP-DDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI- 2487
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVRW-FKDGSEIQFSNHIQLTIDGKKQKLKI 1165
+II L++ + FE+EL+ V W FKD EI+ S+ ++ GK KL +
Sbjct: 2488 -KIIRGLRDLTCTETQNVVFEVELSHSGIDVLWNFKD-KEIKPSSKYKIEAHGKIYKLTV 2545
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
+ DD G+Y+ G + + LTV +I+ L V + +A E+ +
Sbjct: 2546 LNMMKDDEGKYTFYAGENITSGKLTVAGGAISKPLTDQ---TVAESQEAVFECEVANPDS 2602
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
W + + T SD KR LII DD EYT + +K++ KLKVE V
Sbjct: 2603 KGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAV- 2661
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
KI + + D V+ +WI N +++ + S+ SL
Sbjct: 2662 ---KIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSL 2718
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEM-NVTILDKPSPPGKPNILEIDSSSINICWDEP 1404
IK D +Y RL A + + V I+ KP ++ ++++++
Sbjct: 2719 RIKNCAIVDESVYGFRLGRLGASARLHVETVKIIKKPK-----DVTALENATVAFEVSVS 2773
Query: 1405 ENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDA 1464
+T + VE + D +S + + K +QN+ + + + A V +++
Sbjct: 2774 HDTVPVKWFHKNVEIKPSDKHRLVSERKVHKLM--LQNISPSDAGEYTA-VVGQLECK-- 2828
Query: 1465 SETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
K+ ET + K +KNI + C P + W ++G +++
Sbjct: 2829 ------AKLFVETL----HITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEM 2877
Query: 1525 A---KATYENR-XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDI 1580
+ K + + Y + ND +V + V +IT +DI
Sbjct: 2878 SEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGND--QVSATLTV---TPIMITSMLKDI 2932
Query: 1581 KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHS 1640
+ K + VT EGI W KNG ++++ + + TK+ T + I+ + +
Sbjct: 2933 NAEEKDTITFEVTVNYEGI---SYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDA 2989
Query: 1641 SKYTIEASNTAGTSSVEVTLKVYD--------KPSKPEGPVIMREISRESVTIEWKPPLD 1692
+ YT A T+++ V + + K + + + E+S +T++W D
Sbjct: 2990 ADYTFVAGKATSTATLYVEARHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMK--D 3047
Query: 1693 DGGLELT-KYAIEKHE 1707
D L++T + I+K +
Sbjct: 3048 DQELQITDRIKIQKEK 3063
Score = 165 bits (401), Expect = 2e-39
Identities = 188/777 (24%), Positives = 330/777 (42%), Gaps = 67/777 (8%)
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
+P+ EWIV + ++ CK+ S+T K +E + ++++R EN G ++
Sbjct: 8348 KPDSEWIVVTSTLRHCKY----------SVT-KLIEGKEY-LFRVRAENRFGPGPPCVSK 8395
Query: 1376 TILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV 1430
++ K P P KP + ++ S+S+ + W+EP++ G S I+ Y +E +E+++T W V
Sbjct: 8396 PLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNG-SPILGYWLEKREVNSTHWSRV 8454
Query: 1431 KN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL 1488
+ + ++ L +Y FR A N S ++ P + +
Sbjct: 8455 NKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVT 8514
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXX 1544
+T + E GG ++ Y K+L + ++ T +
Sbjct: 8515 DTSSTTIELEWEPPAFNGG---GEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIRE 8571
Query: 1545 XXXYKC--IAFNDHGEV---ETSCV-VGIQQKPVITISNEDIKQKHKV--GDEWLVTAVI 1596
YK A N GE ET V V Q+P + +K ++ G + AV+
Sbjct: 8572 GADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVV 8631
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
G P P +W K +L+ D+ K+ +I IK+ R +Y I A+N+ G+
Sbjct: 8632 TGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELI-IKDALRKDHGRYVITATNSCGSKFA 8690
Query: 1657 EVTLKVYDKPSKPEGPVI-MREI--SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW 1713
++V+D P GPV+ ++ + +R+ + W P DDGG E+T + IE+ + + W
Sbjct: 8691 AARVEVFDVP----GPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTW 8746
Query: 1714 IKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
+ + +R + C I L E EY FRVIA+N G +E PI+ L P+
Sbjct: 8747 RQPIETER---SKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPER 8803
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK---KWKXXXXXXXXXARIQKL 1829
++ + W NGGSPI Y +E ++ K + ++ L
Sbjct: 8804 LTYTER-TKSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENL 8862
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP 1889
+ Y+FR+ A NEIG S P + + + P + R V ++ P
Sbjct: 8863 DEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIP 8922
Query: 1890 ESNGGSPI-------TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
G P+ +IE T + + V+ + E I +D+ + ++A
Sbjct: 8923 ADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTA 8982
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
N +G + ++V +E + PSPP L + + + +W P +GG+ + Y
Sbjct: 8983 SNRLG----SVFRNVHVEVYDR-PSPP-RNLAVTDIKAESCYLTWDAPLDNGGSEITHYV 9036
Query: 2003 IAIRDVT--KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
I RD + K W EV V ++ I L N Y R+ A N+ G+S+ +SD+
Sbjct: 9037 IDKRDASRKKAEWEEVTNTAVEK-RYGIWKLIPNGQYEFRVRAVNKYGISDECKSDK 9092
Score = 165 bits (401), Expect = 2e-39
Identities = 221/972 (22%), Positives = 399/972 (41%), Gaps = 75/972 (7%)
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY-SCEV-GNSKC 1185
IE+ K D L W K +E +T ++ K ++ AG+ SCEV G K
Sbjct: 21793 IEMCKAD-LGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKA 21851
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLI 1245
LT E I+ + + A+ ++ + T W K S + + + +
Sbjct: 21852 VDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQ-GRPTPTAVWSKPDSNL--SLRADIH 21908
Query: 1246 SDVKKRTLIIRKCTEDDQCEYTCVLLD---AKSTT-KLKVEVVEFPPKIVDYEREYRIKR 1301
+ TL + C +D +YT + + +KS T +KV PP + ++ + R
Sbjct: 21909 TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKD---VTR 21965
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS--IDSKSASLTIKKVENTDAGI-- 1357
GS TL+ D P + ++ +++K + ++ S + S+ + I KV + G+
Sbjct: 21966 GS-ATLMWDA---PLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPY 22021
Query: 1358 -YKLRLENNCGHAD-VEMNVTIL--DKPSPPGKPNILEIDSSSINICWDEPENTGNSTII 1413
+++ N G + EM I+ ++P+PP + ++++ SS + W +P++ G S I
Sbjct: 22022 YFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRIT 22081
Query: 1414 YYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
Y++E ++ + W+ + + +++ L + Y FR A N+ S+ E +
Sbjct: 22082 GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSV-I 22140
Query: 1474 IKETKIQSPTVEKPLKN--ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK----TAKA 1527
IKE +I+ + N IT + + G P PKVTW + +LK +
Sbjct: 22141 IKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSIT 22200
Query: 1528 TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVG 1587
T ++R Y N G S V + +P ++ V
Sbjct: 22201 TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVS---SVS 22257
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKY--- 1643
E + V+ P + + N + +E T + S ++ ++K +H +KY
Sbjct: 22258 AE---SCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEY 22314
Query: 1644 --TIEASNTAGTSSVEVTLKV-----YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGL 1696
+ + N G S + + + PS P P + +S +++I W+ P DGG
Sbjct: 22315 SFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVY-HVSANAMSIRWEEPYHDGGS 22373
Query: 1697 ELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-S 1755
++ Y +EK E + W+K V Y + L E EY FR A N G S+A E S
Sbjct: 22374 KIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEAS 22433
Query: 1756 EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK---- 1811
PI+ + +D P + +V + W +GGS ++ Y +E K +
Sbjct: 22434 RPIMAQNPVDAPG----RPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDG 22489
Query: 1812 KWK--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKTLTPPSQ 1868
+W + LS TY+FR+ A+N G S S +T PP
Sbjct: 22490 RWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 22549
Query: 1869 PRNF-VVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV--GGSVHEH 1925
+ + + + + GG P II K K + V++ G
Sbjct: 22550 ELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK-IIWTKGDKELDLCEKVSLQYTGKRATA 22608
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP-PTAPLEIRMVGSNIVM 1984
I+ D + ++ +N G T++ SV ++ + SP P L + V
Sbjct: 22609 VIKFCDRSDSGKYTLTVKNASG----TKAVSVMVK---VLDSPGPCGKLTVSRVTQEKCT 22661
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
+W P+ DGGA + Y + R+ ++ W+ V + + TL + + L +N+ Y+ R+ A
Sbjct: 22662 LAWSLPQEDGGAEITHYIVERRETSRLNWVIV-EGECPTLSYVVTRLIKNNEYIFRVRAV 22720
Query: 2045 NEIGLSEPLESD 2056
N+ G P+ES+
Sbjct: 22721 NKYGPGVPVESE 22732
Score = 163 bits (395), Expect = 8e-39
Identities = 179/733 (24%), Positives = 293/733 (39%), Gaps = 51/733 (6%)
Query: 1358 YKLRLENNCGHADVEMN---VTILDKPSPPGKP-NILEIDSS--SINICWDEPENTGNST 1411
++++ EN G + + V D PPG P N +D++ SI + W +P G +
Sbjct: 11971 FRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP 12030
Query: 1412 IIYYVVEYQE--IDTTE---W---ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISD 1463
II YVVE + D + W + + + + ++ +L N Y FR A N+V I
Sbjct: 12031 IIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGR 12090
Query: 1464 ASETTEYYKVIKETKIQSPTVE---KPLKNITTEPNEDIELTCIFGGVPQPKVTWYR--- 1517
+E E K KE ++ P ++ K + I L I G P PKVTW +
Sbjct: 12091 PAELKEAIKP-KEI-LEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGI 12148
Query: 1518 DGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK--PVITI 1575
D K + Y N GE V + PV +
Sbjct: 12149 DNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL 12208
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKE 1634
D+ K W A E +V Y + + K ++ T E K + +
Sbjct: 12209 KVSDV-TKTSCHVSW---APPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTN 12264
Query: 1635 LKRSHSSKYTIEASNTAG---TSSVEVTLKVYDKPSKPEGP--VIMREISRESVTIEWKP 1689
L + + + A N G + V + D S+P+ P + + E+++ S T+ W P
Sbjct: 12265 LVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLP 12324
Query: 1690 PLDDGGLELTKY--AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PL DGG ++ Y + + E +RW + + V +D+ + + L E +Y FRV A+N V
Sbjct: 12325 PLRDGGAKIDGYITSYREEEQPADRWTEYS-VVKDL-SLVVTGLKEGKKYKFRVAARNAV 12382
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S E+E + +P + + I K P +K
Sbjct: 12383 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGK--PHPTCKWKKGED 12440
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ I+ ++ + + + A N GT T K+ + P
Sbjct: 12441 EVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTD---TQKIKVVVMDAPGP 12497
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P F +S+ + + +L W P +GGS ITNYI+E V W + +
Sbjct: 12498 PQPP--FDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDW--VTALASVTKTS 12553
Query: 1926 C-IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVM 1984
C + + E IFR+ AEN G+S P S + + VPS P + V + +
Sbjct: 12554 CRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEP-KNARVTKVNKDCIF 12612
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
+W P+ DGG+P++GY I ++ +W++ V + ++ L E Y RIYA
Sbjct: 12613 VAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYAL 12672
Query: 2045 NEIGLSEPLESDE 2057
N+ G S P + E
Sbjct: 12673 NKAGSSPPSKPTE 12685
Score = 162 bits (393), Expect = 1e-38
Identities = 159/704 (22%), Positives = 283/704 (40%), Gaps = 35/704 (4%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITK 1435
+++PSPP + SS+ + W+ P G S I+ Y++E E WI ++K + +
Sbjct: 6792 IERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPE 6851
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTE- 1494
+ L+ + Y +R A N+ +SD SE + + PT++ E
Sbjct: 6852 LTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILG--PLTADDAFVEPTMDLSAFKDGLEV 6909
Query: 1495 --PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIA 1552
PN I + G P+P TW K L+T K I
Sbjct: 6910 IVPNP-ITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGI- 6967
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE-----VIWY 1607
+ E + G + V I+ ++ K GD + + PP + + Y
Sbjct: 6968 YTLKLENRVKTISG--EIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGY 7025
Query: 1608 KNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTSS---VEVTLKVY 1663
+ + K + T + + +L + + + A N G V+ + +
Sbjct: 7026 VVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMS 7085
Query: 1664 DKPSKPEGP--VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
+ P+ P V R+ + S+ + W PP +DGG + Y +E+ +++W+ +
Sbjct: 7086 TPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVA 7145
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXID 1780
+ + + L E Y +RV A N G S+ + +E I + P +
Sbjct: 7146 ETKME-VTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLT 7204
Query: 1781 NESVYITWFPSEKNGG-SPIIDY-KVE-IKQEGKKWKXXXXXXXXXARIQKLSINTTYQF 1837
++ P+ G P I + K + I ++ K+ I + T +
Sbjct: 7205 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 7264
Query: 1838 RIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPI 1897
I A N G + T+ ++ + L P P F +++ T+ S L W P +GGS I
Sbjct: 7265 IIEAVNVCGRA---TAVVEVNV---LDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKI 7318
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
TNY++E + + W K+ + + + I K E IFR++AEN GV P ++ +
Sbjct: 7319 TNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNK-EYIFRVAAENMYGVGEPVQASPI 7377
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
+ P PPT LE + + V +W P+ DGG+P+ GY + D W+
Sbjct: 7378 TAKYQFDPPGPPTR-LEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCN 7436
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
K+ V + ++ L+ Y R+ A N G +P +S EP +
Sbjct: 7437 KMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILI 7480
Score = 161 bits (391), Expect = 2e-38
Identities = 238/1087 (21%), Positives = 450/1087 (41%), Gaps = 84/1087 (7%)
Query: 629 LEGIPPTFSKKPKAQYVDE----GSDILLECRLVAIPEPDIAWLFKGEEIVPD-ENISVA 683
L+ +P F K+ K + E GS + EC LV+ W+ G I ++ +A
Sbjct: 4613 LKAVPLKFVKEIKDIILTESEFVGSSAIFEC-LVSPSTAITTWMKDGSNIRESPKHRFIA 4671
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAV--NREGEASLPIVLKIKTGEKEPPQVIEPL 741
D ++ I +V+ G YT V N+E ++ +V+ E+ P + ++ L
Sbjct: 4672 DGKDRKLH-----IIDVQLSDAGEYTCVLRLGNKEKTSTAKLVV-----EELPVRFVKTL 4721
Query: 742 KSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD----GDTHSITILKPKK 796
+ + V +G+ + LS ++ N + W K+ K V P + G ++TI
Sbjct: 4722 EEEVTVVKGQPLYLSCEL--NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADD 4779
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D G YT+ EN+ + +S V VE + +P ++ VK KGT +
Sbjct: 4780 T-DAGTYTVTVENANNLECSSCVKVVEVIRDWLVKP------IRDQHVKPKGTAIFACDI 4832
Query: 857 TRNPVPSITWYRNNEII--SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
++ P+I W++ + I P++ DG ++ L I N E D +Y A GK
Sbjct: 4833 AKD-TPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPE-DIAEY---AVEIEGK 4887
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHR 973
+ A++T+ +V +K ++ E ++ + + S + +W + +
Sbjct: 4888 R-YPAKLTLGEREVELLKPIE-DVTIYEKESASFDAEISEADIPGQWKLKGELLRPSPTC 4945
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDV 1033
EI EG G + + T+ +L VKE +F L+D V E+
Sbjct: 4946 EIKAEGGKRFLTLRKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQ 5005
Query: 1034 AILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
A E + E A+V+W + +IIK +K+D G L I ++ DEG Y+ +
Sbjct: 5006 ARFECVLTRE-ANVIWSKGPDIIK-SSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEG 5063
Query: 1094 ESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
+ +A + V + + ++ L++Q V +G ATF EL+ V WFK+ +++ S +
Sbjct: 5064 KKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVL 5123
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTD 1213
++ +GK KL++ + LDD + +V TA L V E FT++L + V + +
Sbjct: 5124 ISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKD-E 5182
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
L E+ + + V W+K I + K+++ +D +R L I+K D+ EY C
Sbjct: 5183 ITLKCEV-SKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTD 5241
Query: 1274 KSTTKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLLVDYQ-AFPQPNDEWIVNSKIIKKC 1331
K+ + VE +++ E+ Y ++ T + + + P + +W + + +
Sbjct: 5242 KTKANVTVEA-----RLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTAS 5296
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
+ D K L + + G + N A++++ L +P + E
Sbjct: 5297 PDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVFE 5356
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS-VKNITKTQTSIQN--LKTNSS 1448
D + E E + ++ QEI + +K+ TK I++ + +
Sbjct: 5357 KDEAKF-----ECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAK 5411
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGV 1508
Y F A + T +I+ +++ T PLK++T + E T
Sbjct: 5412 YMFEA----------EDKHTSGKLIIEGIRLKFLT---PLKDVTAKEKESAVFTVELSH- 5457
Query: 1509 PQPKVTWYRDGKKLKTAKA-TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
+V W+++ ++L T ++ + ++ I G + + +
Sbjct: 5458 DNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVL 5517
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+ P T +D K DE ++ I P V W+K+G +++ K I K
Sbjct: 5518 EGDPYFTGKLQDYTGVEK--DEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKK 5574
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI-SRESVTIE 1686
++ +K+ +S +YT + GT L + D+ K P+ E+ E+ E
Sbjct: 5575 RMLILKKALKSDIGQYTCD----CGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFE 5630
Query: 1687 WKPPLDD 1693
+ DD
Sbjct: 5631 TEISEDD 5637
Score = 161 bits (390), Expect = 3e-38
Identities = 169/711 (23%), Positives = 284/711 (39%), Gaps = 48/711 (6%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK--NITK 1435
LD PPGKP L I ++ + W +PE TG I Y+VE +++ W+ NI +
Sbjct: 14857 LDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILE 14916
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVD-ISDASETTEYYKVIKETKIQSPTVEKPLK---NI 1491
+ ++ L +++Y FR A N IS SE ++ + +++P ++ +K +
Sbjct: 14917 NEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSD--AITCRDDVEAPKIKVDVKFKDTV 14974
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXX---XXX 1547
+ E L G P P + W +DGK+L+ TAK +
Sbjct: 14975 ILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGA 15034
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWY 1607
Y A N G + V + +P E +V E V+ PP +
Sbjct: 15035 YTLTATNPGGFAKHIFNVKVLDRPG---PPEGPLAVTEVTSE---KCVLSWFPPLDDGGA 15088
Query: 1608 KNGNKLENDKEY------NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-----SSV 1656
K + + +E N+ ++ + + +++ +L + + + + A N G S
Sbjct: 15089 KIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEP 15148
Query: 1657 EVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV 1716
+ + Y P P+ P + I+++S+ + W P DGG E+ Y +E+ + RWIK
Sbjct: 15149 VLAVNPYGPPDPPKNPEVTT-ITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKC 15207
Query: 1717 ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXX 1776
Y + L E EY FR++A+N G S + P
Sbjct: 15208 NKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV 15267
Query: 1777 XXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXAR---IQKLSIN 1832
S+ I W +GGS I Y VEI E +W+ A I L+ N
Sbjct: 15268 LDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTEN 15327
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES-TSRSV-TLKWTEPE 1890
Y+ RIYA N G P + PP + + + T R+ TL+ P
Sbjct: 15328 QEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPI 15387
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE-NIKEKDEIIFRISAENTVGVS 1949
+P + + G+S K S + I N+ D + ++ EN+ G
Sbjct: 15388 KGRPAPEVKWARDH----GESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSG-- 15441
Query: 1950 LPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVT 2009
++S V + T P PP L+++ V V +W P DGG+ + Y + R+ T
Sbjct: 15442 --SKSAFVNVRVLDT-PGPPQ-DLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKREST 15497
Query: 2010 KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
+ + V + + + + L E +Y R+ A NE G+ P E+ E K
Sbjct: 15498 RKAYSTVA-TNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVK 15547
Score = 160 bits (389), Expect = 4e-38
Identities = 192/881 (21%), Positives = 342/881 (38%), Gaps = 84/881 (9%)
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPK 1289
K V + E L + +II +C +Y+ + + T +V+V++ P
Sbjct: 9358 KDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGP 9417
Query: 1290 IVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-------WIVNSKIIKKCKHTKPSIDSKS 1342
D + SD+T ++ P+D+ +++ + I TK + D S
Sbjct: 9418 PKDL-------KVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGS 9470
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCG---HADVEMNVTILDK---PSPPGKPNILEIDSSS 1396
+ + + + +++R EN G + T D P PP K I I ++
Sbjct: 9471 TTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNT 9530
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTT-----EW--ISVKNITKTQTSIQNLKTNSSY 1449
+++ W P+N G S + +Y+VE D T W + +++ + Q ++++L Y
Sbjct: 9531 VHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEY 9590
Query: 1450 RFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNEDIELTCIFGGV 1508
FR AVN +S S T + P+++ LK + E ++ + GV
Sbjct: 9591 EFRVKAVNAAGVSKPSATVGPCDC--QRPDMPPSID--LKEFMEVEEGTNVNIVAKIKGV 9646
Query: 1509 PQPKVTWYR------DGKK-----LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG 1557
P P +TW++ D K+ K ++ Y A N+ G
Sbjct: 9647 PFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLG 9706
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK 1617
+ + +P + IK + D+ + PP + K N + +
Sbjct: 9707 TASKEMRLNVLGRPGPPVG--PIKFESVSADQ----MTLSWFPPKDDGGSKITNYVIEKR 9760
Query: 1618 EYN------ITTKEKTSVIRIKELKRSHSSKYTIEASNTAG-----TSSVEVTLKVYDKP 1666
E N ++++ K I +L H + I A N G S E ++ P
Sbjct: 9761 EANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVP 9820
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVE- 1724
P+ P + ++R S+T+ W+ P DGG +T Y +E + + RW +V D + +
Sbjct: 9821 GAPDKPTV-SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTL 9879
Query: 1725 --TYCIQKLNENCEYMFRVIAQNPVGFSEA-LESEPIVIKTALDVPSXXXXXXXXXXIDN 1781
+Y + L E +Y FRV A N G A L S+P + + P
Sbjct: 9880 GVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWT--K 9937
Query: 1782 ESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXAR--IQKLSINTTYQFR 1838
S + W P K+GGS + Y VE K+EGK +W+ + + L Y+FR
Sbjct: 9938 SSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFR 9997
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESNGGSP 1896
+ A N G P D I + L P + V + ++ S P
Sbjct: 9998 VSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPP 10057
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQS 1956
+ + +T+ ++ + + S+ I+N + + ++ + A+N G E +
Sbjct: 10058 TVTWNMNERTLPQEATIETTAISSSM---VIKNCQRSHQGVYSLLAKNEAG-----ERKK 10109
Query: 1957 VRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV 2016
+ VP P P + + +W +PE DGG+P+ Y I R+ + W V
Sbjct: 10110 TIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPV 10169
Query: 2017 GKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
V ++ L + Y RI A N IG+ +E+ E
Sbjct: 10170 -TYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSE 10209
Score = 159 bits (386), Expect = 1e-37
Identities = 115/396 (29%), Positives = 184/396 (46%), Gaps = 15/396 (3%)
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
D P +PE VI +R +VT++WK P DGG ++T Y +EK + + RW+K + +
Sbjct: 18107 DPPGRPEAIVI----TRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLE 18162
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVG-FSEALESE-PIVIKTALDVPSXXXXXXXXXXIDN 1781
+ + L E+ Y FRVIA+N G FSE +S I + +D P+ I
Sbjct: 18163 TEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVV 18222
Query: 1782 ESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ T+ G PI D V ++GK+ + + IQK ++ R
Sbjct: 18223 HAGE-TFVLEADIRGKPIPD--VVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 18279
Query: 1842 RNEIG--TSLPYTSDDKITIGKTLTPPSQPRN-FVVSESTSRSVTLKWTEPESNGGSPIT 1898
I +++ T IT+ K L P P V+ T+ L W P +GG+ I+
Sbjct: 18280 GQYILKLSNVGGTKSIPITV-KVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANIS 18338
Query: 1899 NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
+YIIE + SWT++ T +++ + + + +E IFR+ A N G+ P ES V
Sbjct: 18339 HYIIEKRETSRLSWTQVSTEVQALN-YKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVT 18397
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
P PP+ P E+ + + ++ +W P DGG + GY + RD W + K
Sbjct: 18398 ACNPYKPPGPPSTP-EVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNK 18456
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
+ L+ + L+E H+Y R+ A N G+ EP E
Sbjct: 18457 KTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSE 18492
Score = 158 bits (384), Expect = 2e-37
Identities = 122/395 (30%), Positives = 175/395 (44%), Gaps = 18/395 (4%)
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
D P +PE ++ +R SVT++WK P DGG ++T Y +EK E RW+K A +
Sbjct: 15943 DPPGRPEAIIV----TRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMK-ASFTNII 15997
Query: 1724 ETYC-IQKLNENCEYMFRVIAQNPVG-FSEALESE-PIVIKTALDVPSXXXXXXXXXXID 1780
+T+ + L E+ Y FRVIA+N G FSE ES I + +D P I
Sbjct: 15998 DTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIV 16057
Query: 1781 NESVYITWFPSEKNGGS-PIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRI 1839
+ ++ G P I + IK + + LS+ R+
Sbjct: 16058 VHAGESFKVDADIYGKPIPTIQW---IKGDQELSNTARLEIKSTDFATSLSVKDAV--RV 16112
Query: 1840 YARNEIGTSLPYTSDDKITIG-KTLTPPSQPRN-FVVSESTSRSVTLKWTEPESNGGSPI 1897
+ N I + + +T+ K L P P V+S T+ TL W P +GGS I
Sbjct: 16113 DSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDI 16172
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
NYI+E + WT +V + + E +E FRI A N GV P ES+ V
Sbjct: 16173 INYIVERRETSRLVWT-VVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPV 16231
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
+ VP P AP E+ V + ++ W P DGG+ +LGY + RD W
Sbjct: 16232 VAKNPFVVPDAPKAP-EVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCH 16290
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
K + L+ + L ENH Y R+ A N GLSEP
Sbjct: 16291 KRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEP 16325
Score = 158 bits (384), Expect = 2e-37
Identities = 113/414 (27%), Positives = 182/414 (43%), Gaps = 14/414 (3%)
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P KP+ P + + +R SV++ W P D+GG ++T Y IE + D + W K +
Sbjct: 23536 PGKPQNPRVT-DTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIRE 23594
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV-IKTALDVPSXXXXXXXXXXID-NES 1783
Y + L + EY FRV+A N G E E V + L+ P I +
Sbjct: 23595 YTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQG 23654
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
I K PI + E + K+ I++ + + + N
Sbjct: 23655 GVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLEN 23714
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
+ G Y K+ + + P P + + RSV + W P +GG+ I YI+E
Sbjct: 23715 KCGKKAVYI---KVRVIGSPNSPEGPLEY--DDIQVRSVRVSWRPPADDGGADILGYILE 23769
Query: 1904 FKTVKGKSWTKIVT-VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQS-VRLEK 1961
+ V +W I + V G+ ++ +KE E FR+SAEN G+S P +S+ V +
Sbjct: 23770 RREVPKAAWYTIDSRVRGT--SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKT 23827
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
P PP+ P E+ V + V SW P+ DGG+ + GY I ++ + W+ K +
Sbjct: 23828 PLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQI 23887
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
T + + L + Y RI A+N++GLSE + EP V+ + +PGE
Sbjct: 23888 TTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEP--VVCKDPFDKPSQPGE 23939
Score = 156 bits (378), Expect = 9e-37
Identities = 106/368 (28%), Positives = 166/368 (45%), Gaps = 15/368 (4%)
Query: 1623 TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRES 1682
+K+ S +R+++ R Y I+ N G + T+ V D P P + +I + S
Sbjct: 8262 SKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTS 8320
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHE---PDNNRWIKVADVDRDVETYCIQKLNENCEYMF 1739
V +W+PPLDDGG E+ Y +EK + PD+ WI V R + Y + KL E EY+F
Sbjct: 8321 VLCKWEPPLDDGGSEIINYTLEKKDKTKPDSE-WIVVTSTLRHCK-YSVTKLIEGKEYLF 8378
Query: 1740 RVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
RV A+N G S+P+V K P N S+ + W K+ GSPI
Sbjct: 8379 RVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN-SMLVKW-NEPKDNGSPI 8436
Query: 1800 IDYKVEIKQ-EGKKWKXXXXXXXXX--ARIQKLSINTTYQFRIYARNEIGTSLPYTSDDK 1856
+ Y +E ++ W A + L TY FR+ A N G D
Sbjct: 8437 LGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 8496
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
T ++PP P V ++++S ++ L+W P NGG I Y ++ + V W++
Sbjct: 8497 KTAHDPISPPGPPIPRV-TDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCT 8555
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIR 1976
V ++ ++ I+E + R+SA N G P E+Q V + A PP L++
Sbjct: 8556 EKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTV---AEPQEPPAVELDVS 8612
Query: 1977 MVGSNIVM 1984
+ G +M
Sbjct: 8613 VKGGIQIM 8620
Score = 155 bits (377), Expect = 1e-36
Identities = 198/880 (22%), Positives = 337/880 (38%), Gaps = 48/880 (5%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA--KSTTKLKVEVV 1284
+TW K + D + S L + D +Y L ++ K + V+V+
Sbjct: 13228 ITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVL 13287
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
+ P V+ + K + VT P ++V + ++ + + + S
Sbjct: 13288 DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS 13347
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHAD---VEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
+ +E + +++ EN G D V P P + + SS +I W
Sbjct: 13348 FRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13407
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDI 1461
+P + G S II YVV++ + +W V Q S ++L Y FR A NE
Sbjct: 13408 KKPHSDGGSRIIGYVVDFL-TEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGE 13466
Query: 1462 SDASETTEYYKVIKETKIQSPTVE-KPLKNI--TTEPNEDIELTCIFGGVPQPKVTWYRD 1518
SE T V+ + +P ++ K L ++ + N + L G P P V+W +
Sbjct: 13467 GTPSEIT----VVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKG 13522
Query: 1519 GKKLKT-AKATYENRXXXXXXXX---XXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT 1574
L T + + E+ Y N G E + + + KP I
Sbjct: 13523 EDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIP 13582
Query: 1575 IS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
D + +W G I K + N+K + + + R+
Sbjct: 13583 TGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDS--VNNKWVTCASAVQKTTFRV 13640
Query: 1633 KELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYDKPSKPEGPVIMREISRESVTIEW 1687
L + + A N G S V +D P P P I+ ++ +SV++ W
Sbjct: 13641 TRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIV-DVRHDSVSLTW 13699
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P GG +T Y +E E ++ W + + + + L E EY FRV+A N
Sbjct: 13700 TDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLA 13759
Query: 1748 GFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
G + +L SEP+V +D P I SV + W + +GG + Y VE
Sbjct: 13760 GVGKPSLPSEPVVALDPIDPPG----KPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEK 13815
Query: 1807 KQ-EGKKWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKT 1862
+ K W + L Y+FRI A+N G S P S + I
Sbjct: 13816 RDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDE 13875
Query: 1863 LTPPSQPRNFVVSES-TSRSVTLKWTEPESNGGSPI--TNYIIEFKTVKGKSWTKIVTVG 1919
P+ + + + T ++ S G P+ +++ K ++ T+I +
Sbjct: 13876 YEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTP 13935
Query: 1920 GSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVG 1979
S I+ KD + I+A N G T+ + V++ VP PP P+EI V
Sbjct: 13936 TS-SMLTIKYATRKDAGEYTITATNPFG----TKVEHVKVTV-LDVPGPP-GPVEISNVS 13988
Query: 1980 SNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMI 2039
+ +W P DGG+P+ Y + R+ ++ +W V + D+ + + L + + Y+
Sbjct: 13989 AEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSE-DIQSCRHVATKLIQGNEYIF 14047
Query: 2040 RIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
R+ A N G EP++S EP K++ G E E + V
Sbjct: 14048 RVSAVNHYGKGEPVQS-EPVKMVDRFGPPGPPEKPEVSNV 14086
Score = 155 bits (376), Expect = 2e-36
Identities = 180/814 (22%), Positives = 322/814 (39%), Gaps = 64/814 (7%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
K +D+ V + P +IV + +++ K T+ + +++
Sbjct: 7600 KNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFR 7659
Query: 1360 LRLENNCGHAD-VEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTII 1413
+ EN G +D E+ ++L K P PP ++++ +++ W+ P+N G I
Sbjct: 7660 VAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQ 7719
Query: 1414 YYVVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
YV+E +E T W+ + + ++ + +F+ A NE + SE TE
Sbjct: 7720 RYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEIL 7779
Query: 1472 KVIKETKIQSPTVEKPLKN-------ITTEPNEDIELTCIFGG----VPQPKVTWYR-DG 1519
+ T SP ++ + + I +P E + I G P W R +
Sbjct: 7780 SIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNS 7839
Query: 1520 KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ-KPVITISNE 1578
+ +K K E I ++ E+ + V KP I +
Sbjct: 7840 RPIKDLKFKVEE--GVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETH 7897
Query: 1579 DIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
DI G++ + +P P V W+K+G +++ + ++ + + + R+
Sbjct: 7898 DIIVIE--GEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRA 7955
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLEL 1698
+ YTI N G+++ + +KV P P + +I++ S + W+PP DGG +
Sbjct: 7956 DAGIYTITLENKLGSATASINVKVIGLPG-PCKDIKASDITKSSCKLTWEPPEFDGGTPI 8014
Query: 1699 TKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
Y +E+ E +I V + + ++ ++ L N EY FRV A N VG E +E +
Sbjct: 8015 LHYVLERREAGRRTYIPVMSGENKL-SWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNP 8073
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWK--X 1815
VI P E++ ITW P +GGS I+ Y +E I + ++WK
Sbjct: 8074 VIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCN 8133
Query: 1816 XXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-V 1874
+ L YQFR+ A N G S P + K + P P+ +
Sbjct: 8134 EHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPT---KAVDPIDAPKVILRT 8190
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYI-----IEFKTVKGKSWTKIVTVGGSVHEH---- 1925
S R + S P +I I + +K ++ + G V E
Sbjct: 8191 SLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFV 8250
Query: 1926 -------CIENIKE-KDEIIFRISAENTVGV-SLPTESQSVRLEKHATVPSPPTAPLEIR 1976
I+N K+ + ++ R S G+ + E+ + TV T I
Sbjct: 8251 LPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN 8310
Query: 1977 MVGSNI----VMTSWGTPEWDGGAPLLGYNIAIRDVTK--TMWMEVGKVDVNTLKFNIRD 2030
V +I V+ W P DGG+ ++ Y + +D TK + W+ V + K+++
Sbjct: 8311 FVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTST-LRHCKYSVTK 8369
Query: 2031 LSENHTYMIRIYARNEIG-----LSEPLESDEPF 2059
L E Y+ R+ A N G +S+PL + +PF
Sbjct: 8370 LIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPF 8403
Score = 153 bits (370), Expect = 9e-36
Identities = 116/432 (26%), Positives = 195/432 (45%), Gaps = 20/432 (4%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY--DKPSKPEGPVIMREISRESVTIEWK 1688
+ + L+ ++ + A N G + Y P P G + R +T++W
Sbjct: 16986 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWT 17045
Query: 1689 PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET-YCIQKLNENCEYMFRVIAQNPV 1747
P+ DGG +T Y +EK + + RW+K A +ET + + L E+ Y FRVIA+N
Sbjct: 17046 KPVYDGGSMITGYIVEKRDLPDGRWMK-ASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA 17104
Query: 1748 G-FSEALESE-PIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGS-PIIDYKV 1804
G S+ +S PI K +++P I + ++ +G P I++
Sbjct: 17105 GAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 17164
Query: 1805 EIKQEGKKWKXXXXXXXXXAR-IQKLSINTTY-QFRIYARNEIGT-SLPYTSDDKITIGK 1861
K+ + + A I K +I Q+ + A N G+ S P K
Sbjct: 17165 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNV-------K 17217
Query: 1862 TLTPPSQPRNFV-VSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG 1920
L P P V V+ TS +L W+ P +GGS I++Y++E + +WT +V
Sbjct: 17218 VLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLAWT-VVASEV 17276
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGS 1980
+ + + E +E +FRI A N GV P ES V ++ +P PP + LE+ +
Sbjct: 17277 VTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKS-LEVTNIAK 17335
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+ + W P+ DGG+ ++GY + RD + W++ K + L+ + L+E+H Y R
Sbjct: 17336 DSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFR 17395
Query: 2041 IYARNEIGLSEP 2052
+ A N G+ EP
Sbjct: 17396 VSAENAAGVGEP 17407
Score = 150 bits (363), Expect = 6e-35
Identities = 198/893 (22%), Positives = 344/893 (38%), Gaps = 49/893 (5%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVK 1249
+E P I+ + + ++V A L + VTW +K I++ + + V
Sbjct: 12104 LEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTW--RKVGIDNVVRKGQVDLVD 12161
Query: 1250 KRT-LIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
L+I T DD +Y+ L++ + + V V++ P + D + K V+
Sbjct: 12162 TMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVS 12221
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
+IV + + + + + K S + + + +++ N
Sbjct: 12222 WAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEY 12281
Query: 1367 GHA---DVEMNVTILD---KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
G DV V D +P PP K + E+ +S + W P G + I Y+ Y+
Sbjct: 12282 GPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYR 12341
Query: 1421 EID--TTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK 1478
E + W + + LK Y+FR A N V +S E Y+ KE +
Sbjct: 12342 EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA-KE-Q 12399
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATY--ENRXX 1534
+ P + P + IT + + + + G P P W + ++ T+ A + ++
Sbjct: 12400 LLPPKILMP-EQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI 12458
Query: 1535 XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK--QKHKVGDEWLV 1592
Y A N G V + P DI W +
Sbjct: 12459 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHI 12518
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
G I + + D + + KTS R+ +L + + A N G
Sbjct: 12519 PLEDGGSNITNYI-VEKCDVSRGDWVTALASVTKTS-CRVGKLIPGQEYIFRVRAENRFG 12576
Query: 1653 TSSVEVTLKV-----YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
S + K+ + PS+P+ + + ++++ + + W P DGG + Y IE+ E
Sbjct: 12577 ISEPLTSPKMVAQFPFGVPSEPKNARVTK-VNKDCIFVAWDRPDSDGGSPIIGYLIERKE 12635
Query: 1708 PDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP 1767
++ W+K D Y L E EY FR+ A N G S S+P TA +P
Sbjct: 12636 RNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSP--PSKPTEYVTA-RMP 12692
Query: 1768 SXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWKXXXXXXXXXARI 1826
+ +V + W + +GGS II Y VE K G KW +
Sbjct: 12693 VDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQE 12752
Query: 1827 Q----KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVV-SESTSRS 1881
+ L YQFR AR + S P D +TI PP + + S T ++
Sbjct: 12753 EYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKA 12812
Query: 1882 VTLKWTEPESNG-GSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
T + G P ++ + +K K + + ++ + ++ KD + I
Sbjct: 12813 GTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIK-MAMQRNLCTLELFSVNRKDSGDYTI 12871
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
+AEN+ G ++S +++L K P PP A ++I + S+ M SW P DGG+ +
Sbjct: 12872 TAENSSG----SKSATIKL-KVLDKPGPP-ASVKINKMYSDRAMLSWEPPLEDGGSEITN 12925
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
Y + R+ ++ W +V V ++ L E H Y RI A N+ G+ +P+
Sbjct: 12926 YIVDKRETSRPNWAQV-SATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPV 12977
Score = 150 bits (363), Expect = 6e-35
Identities = 177/746 (23%), Positives = 296/746 (39%), Gaps = 54/746 (7%)
Query: 1349 KVENTDAGI-YKLRL--ENNCGHADVEMN---VTILDKPSPPGKPNILEIDSSSINICWD 1402
K +N + GI Y+ R+ EN G N D PPG P + + + I + W
Sbjct: 16986 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWT 17045
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
+P G S I Y+VE +++ W+ S N+ +TQ ++ L + Y FR A N
Sbjct: 17046 KPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG 17105
Query: 1461 -ISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
IS S++T E ++ +++ ++ I E L G P P + W R
Sbjct: 17106 AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRG 17165
Query: 1519 GKKLK-TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT 1574
K+++ +A+ +N + Y A N G V + +P
Sbjct: 17166 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 17225
Query: 1575 ISNEDIK--QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIR 1631
+ K W G ++ Y + + + + E T+ ++
Sbjct: 17226 EGPVQVTGVTSEKCSLTWSPPLQDGG---SDISHYVVEKRETSRLAWTVVASEVVTNSLK 17282
Query: 1632 IKELKRSHSSKYTIEASNTAGTSS-VEVTLKVYDKPSKPEGP---VIMREISRESVTIEW 1687
+ +L + + I A N G +E + P GP + + I+++S+T+ W
Sbjct: 17283 VTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCW 17342
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P DGG E+ Y +EK + RWIK + L E+ EY FRV A+N
Sbjct: 17343 NRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAA 17402
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDN--ESVYITWFPSEKNGGSPIIDYKVE 1805
G E S V A D +D S+ + W +GGS I+ Y VE
Sbjct: 17403 GVGEP--SPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVE 17460
Query: 1806 I-KQEGKKWKXXXXXXXXXA---RIQKLSINTTYQFRIYARNEIG----TSLPYT--SDD 1855
I K + ++W+ I KL+ + Y+ R+ A N++G TS+P T +D
Sbjct: 17461 ICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPED 17520
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
K+ + + VV S + + + G P I + +G+ K+
Sbjct: 17521 KLEAPELDLDSELRKGIVVRAGGSARIHIPFK------GRPTPE--ITWSREEGEFTDKV 17572
Query: 1916 -VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLE 1974
+ G + + I+N D + + EN+ G ++S V + K P PP L
Sbjct: 17573 QIEKGVNYTQLSIDNCDRNDAGKYILKLENSSG----SKSAFVTV-KVLDTPGPPQN-LA 17626
Query: 1975 IRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSEN 2034
++ V + W P DGGA + Y I R+ T+ + V T F + +L+E
Sbjct: 17627 VKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKT-SFKVENLTEG 17685
Query: 2035 HTYMIRIYARNEIGLSEPLESDEPFK 2060
Y R+ A NE G+ P+E+ + K
Sbjct: 17686 AIYYFRVMAENEFGVGVPVETVDAVK 17711
Score = 149 bits (362), Expect = 8e-35
Identities = 178/802 (22%), Positives = 301/802 (37%), Gaps = 60/802 (7%)
Query: 1358 YKLRLENNCGHADVE--MNVTILDKP-SPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
+++ EN+ G + T+ P PPG P+ +++ +I + W+ P G S I+
Sbjct: 21332 FRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVG 21391
Query: 1415 YVVEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD-ISDASETTEYY 1471
Y +E ++ W+ + ++++ Q ++ L Y FR A N V IS S+++
Sbjct: 21392 YSIEKRQ-GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGI- 21449
Query: 1472 KVIKETKIQSPTVE---KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG----KKLKT 1524
++ + P VE + + + E + + + G P P+VTW++DG K++
Sbjct: 21450 -IMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNM 21508
Query: 1525 AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH 1584
Y A N G + V +Q P + I+ +
Sbjct: 21509 EITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVG--PIRFTN 21566
Query: 1585 KVGDE---WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
G++ W + +G P I + K E + ++K +K + +
Sbjct: 21567 ITGEKMTLWWDAPLNDGCAP---ITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGN 21623
Query: 1642 KY--TIEASNTAGT----SSVEVTLKV-YDKPSKPEGPVIMREISRESVTIEWKPPLDDG 1694
+Y + A N G S V ++ Y P P P I+ S+T+ W P DG
Sbjct: 21624 EYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE-PSNITGNSITLTWARPESDG 21682
Query: 1695 GLELTKYAIEKHEPDNNRWIKVADVDRDVET-YCIQKLNENCEYMFRVIAQNPVGFSEAL 1753
G E+ +Y +E+ E + RW+KV ET + + L E EY F V+A+N G A
Sbjct: 21683 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPAS 21742
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI-KQEGKK 1812
++ P +V + W +GG II Y +E+ K +
Sbjct: 21743 GISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGD 21802
Query: 1813 WKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQ-- 1868
W R + L Y+FR+ A N G I LT P
Sbjct: 21803 WHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDI 21862
Query: 1869 PRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE 1928
NF + +++ + G P T + K S + S +E
Sbjct: 21863 DANFKQTHVVRAGASIRLF--IAYQGRP-TPTAVWSKPDSNLSLRADIHTTDSFSTLTVE 21919
Query: 1929 NIKEKDEIIFRISAENTVGVSLPTESQSVRLE-KHATVPSPPTAPLEIRMVGSNIVMTSW 1987
N D + ++ EN G S+S+ K P PP P+ + V W
Sbjct: 21920 NCNRNDAGKYTLTVENNSG------SKSITFTVKVLDTPGPP-GPITFKDVTRGSATLMW 21972
Query: 1988 GTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P DGGA + Y + R+ ++ W + + + F + DL+E Y R+ A NE
Sbjct: 21973 DAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQI-FKVNDLAEGVPYYFRVSAVNEY 22031
Query: 2048 GLSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLR-EHNMDADIRSY 2106
G+ EP E EP A E+P + WL+ +H+ + I Y
Sbjct: 22032 GVGEPYEMPEPIV--------ATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGY 22083
Query: 2107 ARGSLLRRDEYFFRIWHYAKQL 2128
+ +++ H KQL
Sbjct: 22084 LLEMRQKGSDFWVEAGH-TKQL 22104
Score = 147 bits (355), Expect = 6e-34
Identities = 117/440 (26%), Positives = 189/440 (42%), Gaps = 28/440 (6%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD------KPSKPEGPVIMREISRESVT 1684
++ L H ++ I A N AG S+ T Y KP P P ++ + SR S++
Sbjct: 15218 KVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVL-DTSRSSIS 15276
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
I W P+ DGG E+T Y +E P+ + W I +Y I L EN EY R+ A
Sbjct: 15277 IAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 15336
Query: 1744 QNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVY-ITWFPSEKNGGSPIID 1801
N G E AL + + P + + + F K +P +
Sbjct: 15337 MNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVK 15396
Query: 1802 YKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK 1861
+ + + K + ++ + ++ + N G+ + + +
Sbjct: 15397 WARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNV------R 15450
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
L P P++ V E T SVTL W P +GGS I NYI+E + K+++ TV +
Sbjct: 15451 VLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYS---TVATN 15507
Query: 1922 VHEHC--IENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMV 1978
H+ ++ ++E FR+ AEN G+ LP E ++SV+ + P PP + + V
Sbjct: 15508 CHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASER---PLPP-GKITLMDV 15563
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
N V SW PE DGG+ +LGY + ++ W V V + I L + Y
Sbjct: 15564 TRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVT--EATITGLIQGEEYS 15621
Query: 2039 IRIYARNEIGLSEPLESDEP 2058
R+ A+NE G+S+P + P
Sbjct: 15622 FRVSAQNEKGISDPRQLSVP 15641
Score = 142 bits (344), Expect = 1e-32
Identities = 203/913 (22%), Positives = 365/913 (39%), Gaps = 83/913 (9%)
Query: 793 KPKKVKDEGVYTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINR-FQEITVKEKGT 849
K + V + V+ L +N E +AV+ E + L I + + I V E T
Sbjct: 2793 KHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKT 2852
Query: 850 IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS 909
V+ VPS+ W +N I SE G+ +L+I N +E DS +Y V
Sbjct: 2853 ASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE-DSAEYTFVCG 2910
Query: 910 NSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEIS 968
N T+ V + L K EE T+ E ++ +S KW N EI
Sbjct: 2911 NDQ------VSATLTVTPIMITSML-KDINAEEKDTITFEVTVNYEGISYKWLKNGVEIK 2963
Query: 969 GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEV 1028
D ++ + D + ++ L V+ EF + ++D +V
Sbjct: 2964 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDIKV 3023
Query: 1029 KEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
EK A+ E E++ V W +D + ++ ++ +K ++ +L I +T + D G+Y+
Sbjct: 3024 LEKKRAMFECEVSEPDITVQWMKDDQELQIT-DRIKIQKEKYVHRLLIPSTRMSDAGKYT 3082
Query: 1089 CILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQF 1148
+ TA++ V I + + +V + +A E E+ + D W+KDG EI F
Sbjct: 3083 VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINF 3142
Query: 1149 S--NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFI 1206
+ ++ + ++ I + DAGEY+ G ++ + L V P L+ + +
Sbjct: 3143 QVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPV 3202
Query: 1207 LVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V + A I ++WYK++ ++ K + D ++ TL++ + +D
Sbjct: 3203 TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAV 3262
Query: 1266 YTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD-YQAFPQP-ND 1319
YTC + A ++ L VEV P++V ++E + + +T L D + QP
Sbjct: 3263 YTCEAKNDYGVATTSASLSVEV----PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3318
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
+ V+ +K ++K S + + E+T Y+L + + + E T +
Sbjct: 3319 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT----YQLEIAE--AYPEDEGTYTFVA 3372
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
N + SS+ N+ + PE+ I++ +E QEI+ + +K + + S
Sbjct: 3373 S-------NAVGQVSSTANLSLEAPES-----ILHERIE-QEIE----MEMKEFSSSFLS 3415
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNED 1498
+ +S+ + +NE + SE+ Y K E + P K + N +
Sbjct: 3416 AEEEGLHSA-ELQLSKINET-LELLSESPVYSTKFDSEKEGTGPIFIKEVSNADISMGDV 3473
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-----NRXXXXXXXXXXXXXXXYKCIAF 1553
L+ G+P+PK+ W+ +G L T A Y+ + Y C+A
Sbjct: 3474 ATLSVTVIGIPKPKIQWFFNG-VLLTPSADYKFVFDGDDHSLIILFTKLEDEGEYTCMAS 3532
Query: 1554 NDHGEVETSCVVGIQQK----------PVITISNED---------IKQKHKVGDEWLVTA 1594
ND+G+ S + I K + S E +K+ + + A
Sbjct: 3533 NDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPA 3592
Query: 1595 VIE----GIPPPEVIWYKNGNKLENDKEYNITTKEKTS-VIRIKELKRSHSSKYTIEASN 1649
+ E G P P V W+K +L Y I S + + +R S Y +A N
Sbjct: 3593 IFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAEN 3652
Query: 1650 TAGTSSVEVTLKV 1662
G S+ L V
Sbjct: 3653 MLGESTCAAELLV 3665
Score = 140 bits (338), Expect = 7e-32
Identities = 102/345 (29%), Positives = 149/345 (43%), Gaps = 14/345 (4%)
Query: 1739 FRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSP 1798
+ + A N G ++A + IV+ LD P I ESV + W P + +GGS
Sbjct: 20050 YEITAANSSGTTKAFIN--IVV---LDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQ 20104
Query: 1799 IIDYKVEIKQEGKK--W-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDD 1855
+ +Y + +K+E W + ++ KL+ YQFRI A N G S +
Sbjct: 20105 VTNY-ILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGIS-DHIDSA 20162
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+T+ T P P V+ T S+T+ W EP SNGGS + Y +E K W K
Sbjct: 20163 CVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQKA 20222
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ + I FR+ AEN GV P+ L A P + I
Sbjct: 20223 NKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDAC---EPPRNVRI 20279
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENH 2035
+ N V SW P +DGG+ + GY + RD+ W + +V +F I L++N
Sbjct: 20280 TDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNS 20339
Query: 2036 TYMIRIYARNEIG-LSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
Y R++ARN +G +S P E P I G + P E TEV
Sbjct: 20340 QYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEV 20384
Score = 137 bits (331), Expect = 5e-31
Identities = 196/790 (24%), Positives = 319/790 (40%), Gaps = 70/790 (8%)
Query: 1214 AYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL- 1271
A L+ +I L D+ WY+ + + K+ + SD + TL + ++D+ YTC+
Sbjct: 24053 AQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATN 24112
Query: 1272 ---DAKSTTKLKVEVV-EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
+ ++++KL ++ +F P E+ Y GS + L V Y P P W K+
Sbjct: 24113 EVGEVETSSKLLLQATPQFHPGYPLKEKYYGAV-GSTLRLHVMYIGRPVPAMTWFHGQKL 24171
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVE-NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
++ ++ L +K V+ T AG YK++L N G D ++V I DKP P
Sbjct: 24172 LQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTG 24231
Query: 1387 PNILE-IDSSSINICWDEPENTGNSTIIYYVVEYQEI-DTTEWISVKN-ITKTQTSIQNL 1443
P ++E + +S I W P + G S I YVVE E + EW V + I+ T I NL
Sbjct: 24232 PIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNL 24291
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTC 1503
N+ Y FR A N ISD E + VI ++ + P P K T +D +C
Sbjct: 24292 TENAGYYFRVSAQNTFGISDPLEVSSV--VIIKSPFEKPGA--PGKPTITAVTKD---SC 24344
Query: 1504 IFGGVPQ-----PKVTWY----RDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIA 1552
+ P K+ Y R+ K+ K T E Y +
Sbjct: 24345 VVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKC 24404
Query: 1553 FNDHGEVETSCV-VGIQQKPVITISNEDIKQKHK---VGDEWLVTAV--IEGIPPPEVIW 1606
N GE E S + I K + I K++ + V + T V + G P P V W
Sbjct: 24405 ENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKW 24464
Query: 1607 YKNGNKLEND-KEYNITT-KEKTSVIRIKELKRSHSSKYTIEASNTAGTSS------VEV 1658
Y+ G ++ D +Y I K + I + ++ Y + A+N G+ S VEV
Sbjct: 24465 YRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEV 24524
Query: 1659 TLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
K++ P EG + + E V+I K P + + + DNN +V
Sbjct: 24525 PAKIH-LPKTLEGMGAVHALRGEVVSI--KIPFSGKPDPVITWQKGQDLIDNNGHYQVI- 24580
Query: 1719 VDRDVETYCIQKLNENCEYMFRVI-AQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXX 1777
V R + E + F V+ A+N G ++ + + + A DVP
Sbjct: 24581 VTRSFTSLVFPNGVERKDAGFYVVCAKNRFG----IDQKTVELDVA-DVPD-PPRGVKVS 24634
Query: 1778 XIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWKXXXXXXXXXARIQKLSINTTYQ 1836
+ +SV +TW +GGS I +Y VE ++W + L T+YQ
Sbjct: 24635 DVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQ 24694
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
FR+ A N+ G S P + T+T + R E + + T+ +
Sbjct: 24695 FRVIAENKFGLSKPSEPSE-----PTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKE 24749
Query: 1897 I-TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQ 1955
+ Y+I +G+ G VH C+E +K + + + T V + E
Sbjct: 24750 LYEKYMIAEDLGRGEF--------GIVH-RCVETSSKKTYMAKFVKVKGTDQVLVKKEIS 24800
Query: 1956 SVRLEKHATV 1965
+ + +H +
Sbjct: 24801 ILNIARHRNI 24810
Score = 134 bits (323), Expect = 4e-30
Identities = 205/920 (22%), Positives = 361/920 (39%), Gaps = 86/920 (9%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
KKPK E + + E + P + W K EI P + + E +H L +
Sbjct: 2753 KKPKDVTALENATVAFEVSVSHDTVP-VKWFHKNVEIKPSDKHRLVSERKVHK----LML 2807
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
N+ G YT V E +A L + E + + +K++ V + ++ +
Sbjct: 2808 QNISPSDAGEYTAVVGQLECKAKLFV---------ETLHITKTMKNIEVPETKTASFECE 2858
Query: 758 VVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V P++ W KN ++ G H + I+ +D YT N +
Sbjct: 2859 VSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTS-TEDSAEYTFVCGNDQ--- 2913
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
SA +TV P + + ++I +EK TI V + S W +N I
Sbjct: 2914 -VSATLTVT--------PIMITSMLKDINAEEKDTITFEVTVNYEGI-SYKWLKNGVEIK 2963
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL 934
++ L I NV D+ DY VA GK++ A + ++ + F KH+
Sbjct: 2964 STDKCQMRTKKLTHSLNIRNVHFG-DAADYTFVA----GKATSTATLYVEARHIEFRKHI 3018
Query: 935 QKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD 993
K + E K + EC+ S ++ +W + +E+ D +I +E D
Sbjct: 3019 -KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3077
Query: 994 VGVIKCIVKDQETSTMLVVKETIPEFIRKLQ-DFEVKEKDVAILEVEINSETADVVWERD 1052
G +V ST + E IR ++ + +V EK A++E E+N + D W +D
Sbjct: 3078 AGKYT-VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3136
Query: 1053 GEIIK---PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL-RDESCTAEVTVVELPPE 1108
G I +++KY E+R H +++I T D GEY+ + R+ S PP+
Sbjct: 3137 GIEINFQVQERHKYVVERRIH--RMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQ 3194
Query: 1109 IITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
++ LQ V G A F ++ + + W+K+ + + DG++ L + +
Sbjct: 3195 VLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIE 3254
Query: 1168 CDLDDAGEYSCEVGN----SKCTAILTVEEPSI-NFTLRLPEF---ILVPANTD------ 1213
+DA Y+CE N + +A L+VE P + + +P + I+ P
Sbjct: 3255 AFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQ 3314
Query: 1214 -AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
A + L V+WY K I+ + F + L I + +D+ YT V +
Sbjct: 3315 PARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASN 3374
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI-IKKC 1331
A + P+ + +E RI++ ++ + +F +E + ++++ + K
Sbjct: 3375 AVGQVSSTANLSLEAPESILHE---RIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKI 3431
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAG-IYKLRLEN-NCGHADV-EMNVTILDKPSPPGK-- 1386
T + T E G I+ + N + DV ++VT++ P P +
Sbjct: 3432 NETLELLSESPVYSTKFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWF 3491
Query: 1387 -PNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKT 1445
+L S+ +D + +S II + E + T ++ + KT S LK
Sbjct: 3492 FNGVLLTPSADYKFVFDGDD---HSLIILFTKLEDEGEYT-CMASNDYGKTICSAY-LKI 3546
Query: 1446 NSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF 1505
NS E ++ + E K P K LK I
Sbjct: 3547 NSKGEGHKDTETESAVAKSLE--------KLGGPCPPHFLKELKPIRCAQGLPAIFEYTV 3598
Query: 1506 GGVPQPKVTWYRDGKKLKTA 1525
G P P VTW+++ K+L T+
Sbjct: 3599 VGEPAPTVTWFKENKQLCTS 3618
Score = 133 bits (321), Expect = 8e-30
Identities = 118/411 (28%), Positives = 171/411 (41%), Gaps = 31/411 (7%)
Query: 1666 PSKPEGPVIMREIS---RESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
P KP GP E+S ++S+ + W P+DDGG E+ Y +EK + + RW K
Sbjct: 18401 PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLT 18460
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV--PSXXXXXXXXXXID 1780
+ L E Y FRV A+N G E SEP V A D P
Sbjct: 18461 DLRLRVTGLTEGHSYEFRVAAENAAGVGEP--SEPSVFYRACDALYPPGPPSNPKVTDTS 18518
Query: 1781 NESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXAR---IQKLSINTTYQ 1836
SV + W +GG+P+ Y VE+K+ +W + + KL NT Y
Sbjct: 18519 RSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYN 18578
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPP-----SQPRNFVVSESTSRSVTLKWTEPES 1891
FRI A N G P T + + + PP + R VV + S TL+
Sbjct: 18579 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA---SATLRLFVTIK 18635
Query: 1892 NGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
P ++++ +G + + V S I+N+ D + ++ EN G
Sbjct: 18636 GRPEP----EVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSK- 18690
Query: 1951 PTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTK 2010
T +VR+ PS P L IR V + V SW P DGGA + Y + R+ T+
Sbjct: 18691 -TAFVNVRV---LDSPSAP-VNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTR 18745
Query: 2011 TMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
+ + T F I +L E +Y R+ A NE G+ P E+ EP KV
Sbjct: 18746 KAYATITNNCTKT-TFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKV 18795
Score = 129 bits (311), Expect = 1e-28
Identities = 112/445 (25%), Positives = 188/445 (42%), Gaps = 29/445 (6%)
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLK--VYDKPSKPEGPVI---MREISRESVT 1684
++++ L H ++ ++A N G + + V P +P GP + + ++ S+T
Sbjct: 11958 MKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSIT 12017
Query: 1685 IEWKPPLDDGGLELTKYAIEKH------EPDNNRWIKVADVDRDV-ETYCIQKLNENCEY 1737
+ W P+ DGG + Y +E PD W + + V + + + L+EN EY
Sbjct: 12018 LGWGKPVYDGGAPIIGYVVEMRPKIADASPDEG-WKRCNAAAQLVRKEFTVTSLDENQEY 12076
Query: 1738 MFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXX-IDNESVYITWFPSEKNG 1795
FRV AQN VG E E I K L+ P I I F +
Sbjct: 12077 EFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGR 12136
Query: 1796 GSPIIDY-KVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSD 1854
+P + + KV I +K + I + + + ++ + N G + +
Sbjct: 12137 PAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNV 12196
Query: 1855 DKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTK 1914
+ L P + VS+ T S + W PE++GGS +T+YI+E + K+W+
Sbjct: 12197 ------RVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWST 12250
Query: 1915 IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPL 1973
+ H + N+ +E FR++A N G +PT+ + V + P PP L
Sbjct: 12251 VTPEVKKTSFH-VTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPP-RKL 12308
Query: 1974 EIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTK--TMWMEVGKVDVNTLKFNIRDL 2031
E+ + N +W P DGGA + GY + R+ + W E V L + L
Sbjct: 12309 EVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSV--VKDLSLVVTGL 12366
Query: 2032 SENHTYMIRIYARNEIGLSEPLESD 2056
E Y R+ ARN +G+S P E++
Sbjct: 12367 KEGKKYKFRVAARNAVGVSLPREAE 12391
Score = 125 bits (302), Expect = 2e-27
Identities = 86/303 (28%), Positives = 131/303 (43%), Gaps = 7/303 (2%)
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-K 1812
+S PI +K LD P + E Y+ W P ++GG+ I Y +E ++ +
Sbjct: 18293 KSIPITVKV-LDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLS 18351
Query: 1813 W-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
W + ++ KL Y FR+ A N+ G P S +T PP P
Sbjct: 18352 WTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGP-VTACNPYKPPGPPST 18410
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIK 1931
VS T S+ + W P +GG+ I YI+E + +G WTK + + +
Sbjct: 18411 PEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLT 18470
Query: 1932 EKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP 1990
E FR++AEN GV P+E S R P PP+ P ++ + V +W P
Sbjct: 18471 EGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNP-KVTDTSRSSVSLAWSKP 18529
Query: 1991 EWDGGAPLLGYNIAIRDVTKTMWME-VGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGL 2049
+DGGAP+ GY + +++ W + +F + L EN Y RI A N G+
Sbjct: 18530 IYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGV 18589
Query: 2050 SEP 2052
EP
Sbjct: 18590 GEP 18592
Score = 124 bits (300), Expect = 3e-27
Identities = 90/303 (29%), Positives = 135/303 (44%), Gaps = 11/303 (3%)
Query: 1757 PIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKX 1815
PI + T L PS I +SV ++W E NGG I Y +E ++ + WK
Sbjct: 21151 PITVIT-LGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKM 21209
Query: 1816 XXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK-TLTPPSQPRNFV 1873
++ L + YQFR+ A N G S P S I + K P P V
Sbjct: 21210 VCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSS--IIVAKHQFRIPGPPGKPV 21267
Query: 1874 VSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEK 1933
+ TS ++L W P +GGS +T + +E K W K+ T S E+ + E
Sbjct: 21268 IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEG 21327
Query: 1934 DEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+ FR+ AEN+ G+S P++ L + PP P I + I + W P D
Sbjct: 21328 LDYQFRVYAENSAGLSSPSDPSKFTLA--VSPVDPPGTPDYIDVTRETITL-KWNPPLRD 21384
Query: 1994 GGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG-LSEP 2052
GG+ ++GY+I R + W+ DV+ ++ + LS Y RI ARN +G +S P
Sbjct: 21385 GGSKIVGYSIEKRQGNER-WVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPP 21443
Query: 2053 LES 2055
+S
Sbjct: 21444 SQS 21446
Score = 124 bits (298), Expect = 5e-27
Identities = 123/454 (27%), Positives = 188/454 (41%), Gaps = 34/454 (7%)
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
T+ ++ L ++ ++A N G S + L V + + P I +S TI+
Sbjct: 8854 TTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVP-PTIKLRLSVRGDTIK 8912
Query: 1687 WKP------PLDDGGLELTKYAIEKHE-----PDNNRWIKVADVDR-DVET-YCIQKLNE 1733
K P D GL + K K+E P + I +V R + +T I K
Sbjct: 8913 VKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVR 8972
Query: 1734 NCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEK 1793
+ + V A N +G + + + D PS I ES Y+TW
Sbjct: 8973 EDKGTYTVTASNRLG--SVFRNVHVEV---YDRPSPPRNLAVTD-IKAESCYLTWDAPLD 9026
Query: 1794 NGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXAR-IQKLSINTTYQFRIYARNEIGTSL 1849
NGGS I Y ++ + +K W+ I KL N Y+FR+ A N+ G S
Sbjct: 9027 NGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISD 9086
Query: 1850 PYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKG 1909
SD K+ I P P V T S+ + WT P NGGSPIT Y +E +
Sbjct: 9087 ECKSD-KVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGS 9145
Query: 1910 KSWTK-----IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHAT 1964
W++ I VG E + + E + FR A N G+ P+E +
Sbjct: 9146 PYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPI 9205
Query: 1965 VP-SPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD--V 2021
P PP+ P E++ + + W P DGG+P+ GY + +++ T W V + D +
Sbjct: 9206 FPPGPPSCP-EVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLI 9264
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
T + + +L E Y R+ A NE G SEP ++
Sbjct: 9265 TTCECVVPNLKELRKYRFRVKAVNEAGESEPSDT 9298
Score = 123 bits (297), Expect = 6e-27
Identities = 83/293 (28%), Positives = 131/293 (44%), Gaps = 15/293 (5%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK--WKXXXXXXXX-XARIQKLSINTTY 1835
+ ++ + W P E +GG I +Y +E K E K+ W + +L Y
Sbjct: 11811 VSSDRCTVCWDPPEDDGGCEIQNYILE-KCETKRMVWSTYSATVLTPGTTVTRLIEGNEY 11869
Query: 1836 QFRIYARNEIGTSLPYTSDDKITIGKT-LTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
FR+ A N+IGT P ++ K I KT P +P V++ + +T+ W PE +GG
Sbjct: 11870 IFRVRAENKIGTGPP--TESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGG 11927
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT-E 1953
IT Y +E K W + ++N+ E FR+ AEN +G+ P+
Sbjct: 11928 KSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLP 11987
Query: 1954 SQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMW 2013
S+ V + P PPT + +I + WG P +DGGAP++GY + +R
Sbjct: 11988 SRPVVAKDPIEPPGPPTNFRVVDTTKHSITL-GWGKPVYDGGAPIIGYVVEMRPKIADAS 12046
Query: 2014 MEVGKVDVNTL------KFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
+ G N +F + L EN Y R+ A+N++G+ P E E K
Sbjct: 12047 PDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIK 12099
Score = 123 bits (296), Expect = 8e-27
Identities = 145/607 (23%), Positives = 241/607 (39%), Gaps = 44/607 (7%)
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAK-ATYENRXXXXXXXXXX----XXXXXYKCIAF 1553
+ L ++ G P P +TW+ K L+ ++ T EN YK
Sbjct: 24149 LRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLS 24208
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV--IWYKNG- 1610
N G V+ V IQ KP I+ K +AVI PP + W N
Sbjct: 24209 NVFGTVDAILDVEIQDKPDKPTGPIVIEALLKN------SAVISWKPPADDGGSWITNYV 24262
Query: 1611 -NKLENDK--EYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAG------TSSVEVTL 1660
K E + E+ + + + RI L + + + A NT G SSV +
Sbjct: 24263 VEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIK 24322
Query: 1661 KVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVD 1720
++KP P P I ++++S + WKPP DGG ++ Y +EK E N+WI V +
Sbjct: 24323 SPFEKPGAPGKPTITA-VTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEE 24381
Query: 1721 RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXI 1779
+ ++ L E EY FRV +N G SE E SEPI K+ + + +
Sbjct: 24382 IRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLN 24441
Query: 1780 DNESVYITWFPSEKNGGSPIIDYK---VEIKQEGKKWKXXXXXXXXXARI-QKLSINTTY 1835
T PI+ + EI +G K++ I ++ +
Sbjct: 24442 VRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDAT 24501
Query: 1836 QFRIYARNEIGTSLPYTSDDKITI-GKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
+++ A N+ G S+ T+ ++ + K P + V V++K P S
Sbjct: 24502 VYQVRATNQ-GGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI--PFSGKP 24558
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
P+ + + +++ ++ KD + + A+N G+ +
Sbjct: 24559 DPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI----DQ 24614
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
++V L+ A VP PP +++ V + V +W P DGG+ + Y + T W+
Sbjct: 24615 KTVELDV-ADVPDPPRG-VKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWL 24672
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP--FKVIPGEGSHADEE 2072
VG+ ++ + +L +Y R+ A N+ GLS+P E EP K + DEE
Sbjct: 24673 RVGQA--RETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITKEDKTRAMNYDEE 24730
Query: 2073 PGEQTEV 2079
E EV
Sbjct: 24731 VDETREV 24737
Score = 120 bits (288), Expect = 8e-26
Identities = 88/313 (28%), Positives = 139/313 (44%), Gaps = 10/313 (3%)
Query: 1764 LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXX 1822
LD P + E + W P ++GGS II+Y VE ++ + W
Sbjct: 16137 LDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQT 16196
Query: 1823 XA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS 1881
+ ++ KL Y FRI A N+ G P S+ + + P + P+ V+ T S
Sbjct: 16197 LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDA-PKAPEVTTVTKDS 16255
Query: 1882 VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRI 1940
+ + W P S+GGS I Y++E + +G WT+ + G + + + E + FR+
Sbjct: 16256 MIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLR-VTGLIENHDYEFRV 16314
Query: 1941 SAENTVGVSLPTESQSVRLEKHATV-PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLL 1999
SAEN G+S P+ + + P PP P I + S++ + SW P +DGG +
Sbjct: 16315 SAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFL-SWSKPIYDGGCEIQ 16373
Query: 2000 GYNIAIRDVTKTMW-MEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
GY + DV+ W M +N + L E H Y RI A N+ G+ E +D P
Sbjct: 16374 GYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGE--HADVP 16431
Query: 2059 FKVIPGEGSHADE 2071
+I E A +
Sbjct: 16432 GPIIVEEKLEAPD 16444
Score = 115 bits (276), Expect = 2e-24
Identities = 109/456 (23%), Positives = 179/456 (39%), Gaps = 28/456 (6%)
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
EY++ V +KE K+ K+ + A N G S VY+ + P I+
Sbjct: 12352 EYSVVKDLSLVVTGLKEGKKY---KFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMP 12408
Query: 1678 ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEY 1737
E +TI+ L + + K P +W K D + K + +
Sbjct: 12409 ---EQITIKAGKKL-----RIEAHVYGKPHP-TCKWKKGEDEVVTSSHLAVHKADSSSIL 12459
Query: 1738 MFRVIAQNPVGF-------SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
+ + + + G+ S +++ I + +D P ID ++ ++W
Sbjct: 12460 IIKDVTRKDSGYYSLTAENSSGTDTQKIKV-VVMDAPGPPQPPFDISDIDADACSLSWHI 12518
Query: 1791 SEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTS 1848
++GGS I +Y VE + W + R+ KL Y FR+ A N G S
Sbjct: 12519 PLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGIS 12578
Query: 1849 LPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVK 1908
P TS K+ PS+P+N V++ + + W P+S+GGSPI Y+IE K
Sbjct: 12579 EPLTSP-KMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN 12637
Query: 1909 GKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
W K E+ + E E FRI A N G S P++ A +P
Sbjct: 12638 SLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVT---ARMPVD 12694
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV--DVNTLKF 2026
P E+ V + V W P+ DGG+ ++GY + + W+ + ++
Sbjct: 12695 PPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEY 12754
Query: 2027 NIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVI 2062
L E Y R AR + +S P E +P ++
Sbjct: 12755 TATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 12790
Score = 107 bits (258), Expect = 3e-22
Identities = 105/448 (23%), Positives = 177/448 (39%), Gaps = 41/448 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P V L+ +G +V EC + GYP P +TW+R+ I+ S DFQ+ + +A L+
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF-QSGIARLM 955
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXXXXXXXXAD 627
IRE F ED+G FTC A N AG S++ L V+ + +T D
Sbjct: 956 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRD 1015
Query: 628 IL--------------EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEE 673
++ E P F KP Q + EG ++ C++ P+P + W G
Sbjct: 1016 VVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVP 1075
Query: 674 IVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE 733
+ V+ V+ +T G YT+V N+ GE S L E +
Sbjct: 1076 LTTGYRYKVSYNKQTGECKLVISMTFAD--DAGEYTIVVRNKHGETSASASL---LEEAD 1130
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
+++ + M+ + + + VG P + + K + T++
Sbjct: 1131 YELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVV 1190
Query: 794 PKKVKDEGVYTLKAENS--EGIAETSAVITVEEPTEENAEPPLFIN-------------R 838
V+D+ + E + I T+EE EE+ E + ++ R
Sbjct: 1191 RTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDLR 1250
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF--DGENIELVITNVD 896
+ + E + +++ P+P I WY++ + I E +F DG L I V
Sbjct: 1251 IKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVL 1309
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTID 924
E D G Y ASN G + ++ ++
Sbjct: 1310 PE-DEGIYTAFASNIKGNAICSGKLYVE 1336
Score = 107 bits (258), Expect = 3e-22
Identities = 77/283 (27%), Positives = 123/283 (43%), Gaps = 11/283 (3%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK---KWKXXXXXXXXXA-RIQKLSINTT 1834
I SV W P +GGS II+Y +E K + K +W + KL
Sbjct: 8316 IRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKE 8375
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
Y FR+ A N G P S + PP P +V + TS S+ +KW EP+ NG
Sbjct: 8376 YLFRVRAENRFGPGPPCVSKPLVA-KDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNG- 8433
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
SPI Y +E + V W+++ + + ++ + E +FR+ AEN G P +
Sbjct: 8434 SPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAG---PGKF 8490
Query: 1955 QSVRLEKHATVP-SPPTAPL-EIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM 2012
K A P SPP P+ + S + W P ++GG ++GY + + V
Sbjct: 8491 SPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNE 8550
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
W + + ++ ++++ E Y +R+ A N G P E+
Sbjct: 8551 WSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGET 8593
Score = 107 bits (258), Expect = 3e-22
Identities = 80/287 (27%), Positives = 127/287 (44%), Gaps = 12/287 (4%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXA-RIQKLSINTTYQ 1836
+ ES ++W + GG+ I +Y VE ++ G W+ ++ L+ Y
Sbjct: 22256 VSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYS 22315
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
FR+ + N G S P S I PPS P V ++ +++++W EP +GGS
Sbjct: 22316 FRVSSENRFGVSKPLESAP-IIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSK 22374
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQ 1955
I Y +E K W K V + + + E E FR A N GVS +E S+
Sbjct: 22375 IIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASR 22434
Query: 1956 SVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKT---M 2012
+ + P P E+ V + V W P +DGG+ ++GY I + V++
Sbjct: 22435 PIMAQNPVDAPGRP----EVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGR 22490
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG-LSEPLESDEP 2058
W++ V+ F + LSE TY R+ A+N G +S+ ES P
Sbjct: 22491 WLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGP 22537
Score = 107 bits (256), Expect = 6e-22
Identities = 116/515 (22%), Positives = 208/515 (40%), Gaps = 31/515 (6%)
Query: 1554 NDHGEVETSCVVGIQQK--PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWY--KN 1609
NDHG + C V + P I EDI+ K V +W + +G E+I Y +
Sbjct: 8288 NDHGIAKAPCTVSVLDTPGPPINFVFEDIR-KTSVLCKW-EPPLDDG--GSEIINYTLEK 8343
Query: 1610 GNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAG-----TSSVEVTLKVY 1663
+K + D E+ + T + + +L + + A N G S V +
Sbjct: 8344 KDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPF 8403
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
P P+ P++ +++ S+ ++W P D+G + Y +EK E ++ W +V +
Sbjct: 8404 GPPDAPDKPIV-EDVTSNSMLVKWNEPKDNGS-PILGYWLEKREVNSTHWSRVNKSLLNA 8461
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALD-VPSXXXXXXXXXXIDNE 1782
+ L E Y+FRV A+N G + S P KTA D + +
Sbjct: 8462 LKANVDGLLEGLTYVFRVCAENAAGPGKF--SPPSDPKTAHDPISPPGPPIPRVTDTSST 8519
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXAR--IQKLSINTTYQFRI 1839
++ + W P NGG I+ Y V+ + G +W + ++++ Y+ R+
Sbjct: 8520 TIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRV 8579
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N G P +T+ + PP+ + V P G P+
Sbjct: 8580 SAVNAAGEG-PPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPT 8638
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
+ + + ++ G+ E I++ KD + I+A N+ G ++ + R+
Sbjct: 8639 KVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCG----SKFAAARV 8694
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
E VP P L+ + + + +W PE DGG+ + G+ I +D W + +
Sbjct: 8695 EVF-DVPG-PVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQ--PI 8750
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
+ K +I L E Y R+ A+N+ G P+E
Sbjct: 8751 ETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVE 8785
Score = 104 bits (249), Expect = 4e-21
Identities = 81/313 (25%), Positives = 140/313 (44%), Gaps = 19/313 (6%)
Query: 523 DGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G V++ C++E Y + Q+TW+ ++ S+ +++ Y+D VA L ++++ D GT+
Sbjct: 25084 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYED-GVAILYVKDITKLDDGTY 25142
Query: 582 TCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
C N G SS EL V+ + D+ T+ +LE PP F+
Sbjct: 25143 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMR---LLER-PPEFTLP 25198
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHMYCSVLKIT 698
+ G ++ + PEP + W G++I P D + ESD +Y L I
Sbjct: 25199 LYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLY--QLTIN 25256
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV-----RQGESVI 753
+V + YTVVA N+ GE S L + + P+ ++ ++G+SV
Sbjct: 25257 SVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVC 25316
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYTLKAENS 810
+V G P PT+ W K+ +P+ P +G + ++ +D G Y + A N+
Sbjct: 25317 FEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNT 25376
Query: 811 EGIAETSAVITVE 823
G A + VE
Sbjct: 25377 AGSTSCQAHLQVE 25389
Score = 104 bits (249), Expect = 4e-21
Identities = 172/833 (20%), Positives = 327/833 (39%), Gaps = 71/833 (8%)
Query: 736 QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK 795
+++ +SM V +GES S G P PT+TW + + + T + +
Sbjct: 26065 RILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEIS 26124
Query: 796 KVK--DEGVYTLKAENSEGIAETSAVITVEEP--TEENAEPPLFINRFQEITVKEKGTIK 851
V+ DEG Y++ ENSEG E +T+++ TE+ P + + E VK +K
Sbjct: 26125 SVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRV-KSPEPRVKSPEAVK 26183
Query: 852 LVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNS 911
RV ++P PS + + +SP+ET + E ++ + + +I K AS
Sbjct: 26184 SPKRV-KSPEPS-----HPKAVSPTET--KPTPTEKVQHLPVSAPPKITQF-LKAEASKE 26234
Query: 912 AGKSSHGARVTI-DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGM 970
K + ++ ++VT+ K +K E + T K + + G
Sbjct: 26235 IAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQ---FHYSADGTYELKINNLTESDQGE 26291
Query: 971 DHREIIQEGRXXXXXXXXXXXXDVGVIKCIVK-------DQETSTMLVVKETIPE----- 1018
EI EG + + + K DQ+T+ V ++T P+
Sbjct: 26292 YVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPI 26351
Query: 1019 -----FIRKLQDFEVKEKDVAILEVEINSETADV-VWERDGEII-KPKKNKYDFEKRGHI 1071
+ LQD V VA V+ E +W +DG+ I + K K +K G
Sbjct: 26352 SSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFF 26411
Query: 1072 RKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELT 1131
L I T D G Y+C +++ + + + +L + I + QKV+ + T EI
Sbjct: 26412 --LEIHKTDTSDSGLYTCTVKNSAGSVSSSC-KLTIKAIKDTEAQKVS--TQKTSEITPQ 26466
Query: 1132 KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY--SCEVGNSKCTAI- 1188
K A+V+ ++ S I+++ ++KL + + +A + S EV S T++
Sbjct: 26467 K-KAVVQEEISQKALR-SEEIKMSEAKSQEKLALKE----EASKVLISEEVKKSAATSLE 26520
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDE------------TLDVTWYKKKSVI 1236
++ I T + E + A A+ T +E DV W +
Sbjct: 26521 KSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVEL 26580
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-----VEFPPKIV 1291
++E++ +TL I++ + D+ TC+ + K + ++ + P +
Sbjct: 26581 TNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFI 26640
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
R I G +V + P P EW N+ I + S SL I+
Sbjct: 26641 SQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNAS 26700
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+D+G Y ++ +N G ++ +L P + +L S ++ + +
Sbjct: 26701 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLR-TSGDTSLQGSFSSQSVQMS 26759
Query: 1412 IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
+ ++ S+ + S Q++ + + + + IS+ ++
Sbjct: 26760 ASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESST 26819
Query: 1472 KVIKETKIQS--PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ + I+ P +E +I+ + + + + C F G P P+VTW G+K+
Sbjct: 26820 SKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI 26872
Score = 99 bits (238), Expect = 9e-20
Identities = 108/439 (24%), Positives = 183/439 (41%), Gaps = 33/439 (7%)
Query: 1044 TADVVWERD-GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT--AEV 1100
T ++ W R+ GE +K EK + +L I N +D G+Y L + S + A V
Sbjct: 17556 TPEITWSREEGEFT----DKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFV 17611
Query: 1101 TVVELP-PEIITRLQNQKVNKGNK-ATFEIELTKGDALVR-WFKDGSEIQFSNHIQLTID 1157
TV L P L ++V K + +E + G A V+ + D E + ++
Sbjct: 17612 TVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSK 17671
Query: 1158 GKKQKLK--------IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
K K IY + E+ V A+ E PS + L +
Sbjct: 17672 CSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDV---- 17727
Query: 1210 ANTDAYLTVEIP--DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ T A L E P D V Y + + TEK++++++ K ++ + + ++
Sbjct: 17728 SQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFR 17787
Query: 1268 CVLLDAKSTTKLKVEVVEFPPKIVDYE-------REYRIKRGSDVTLLVDYQAFPQPNDE 1320
+ K + +V V K + + Y I+ G D+ + + P+PN
Sbjct: 17788 VKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNIS 17847
Query: 1321 WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
W+ + + +K+ + S L IK+ D G Y + N+ G A ++V +L+K
Sbjct: 17848 WVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 17907
Query: 1381 PSPP-GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQT 1438
P PP G E+ + + I W+ P TG I Y+VE ++ TT W V + +T
Sbjct: 17908 PGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTI 17967
Query: 1439 SIQNLKTNSSYRFRAYAVN 1457
I LKT + Y+FR +A N
Sbjct: 17968 KITKLKTGTEYQFRIFAEN 17986
Score = 95.5 bits (227), Expect = 2e-18
Identities = 60/204 (29%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 713 VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN 772
++R ++ I K+ +GE P + + +K + + GE+ LS Q+VG P P I W +
Sbjct: 24016 LSRPRRTAMSIKTKLTSGEA--PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFG 24073
Query: 773 KPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
K + + SDG TH++T++ ++ +DEGVYT A N G ETS+ + ++ + +
Sbjct: 24074 KELIQSRKYKMSSDGRTHTLTVMTEEQ-EDEGVYTCIATNEVGEVETSSKLLLQATPQFH 24132
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE 889
PL + + T++L PVP++TW+ +++ SE IT
Sbjct: 24133 PGYPLKEKYYGAVG----STLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTH 24188
Query: 890 LVITNVDSEIDSGDYKCVASNSAG 913
LV+ NV + +G YK SN G
Sbjct: 24189 LVMKNVQRKTHAGKYKVQLSNVFG 24212
Score = 91.5 bits (217), Expect = 3e-17
Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA--LP----TKSDGDT 786
+ P +PL+S++V +G + A + G P P ++W ++ + + LP + SDG
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
+TI K + G Y+LKA N G A ++A + V+ T PP F+ R Q +TV++
Sbjct: 64 -KLTIPAVTKA-NSGRYSLKATNGSGQATSTAELLVKAETA----PPNFVQRLQSMTVRQ 117
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
++L RVT P P + +YR+ I S + +G+ L+I E DSG Y
Sbjct: 118 GSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPE-DSGTYSV 176
Query: 907 VASNSAGKSSHGARVTIDVEK 927
A+NS G+++ A + + E+
Sbjct: 177 NATNSVGRATSTAELLVQGEE 197
Score = 91.5 bits (217), Expect = 3e-17
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTH 787
+P V++P+ S +G++ +VVG P P W + + + + K DG T
Sbjct: 1410 KPVFVLKPV-SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG-TQ 1467
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
S+ I+ P D G +T+ A+N G + S ++TVE E+ P+F+ + + + +KE
Sbjct: 1468 SLIIV-PATPSDSGEWTVVAQNRAGRSSISVILTVE--AVEHQVKPMFVEKLKNVNIKEG 1524
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEI--DSGDYK 905
+++ R T NP P I W +N++II P + +G E + +DS + DS Y
Sbjct: 1525 SQLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL-KIDSTVSQDSAWYT 1583
Query: 906 CVASNSAGKSSHGARVTIDVE 926
A N AG+ + +V ++VE
Sbjct: 1584 ATAINKAGRDTTRCKVNVEVE 1604
Score = 89.0 bits (211), Expect = 2e-16
Identities = 54/175 (30%), Positives = 80/175 (45%), Gaps = 9/175 (5%)
Query: 1298 RIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK----CKHTKPSIDSKSAS--LTIKKVE 1351
++K G V + D P P EW N +I+K + TK + A L+I K
Sbjct: 8912 KVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAV 8971
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
D G Y + N G ++V + D+PSPP + +I + S + WD P + G S
Sbjct: 8972 REDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSE 9031
Query: 1412 IIYYVVEYQEID--TTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISD 1463
I +YV++ ++ EW V N + + I L N Y FR AVN+ ISD
Sbjct: 9032 ITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISD 9086
Score = 88.2 bits (209), Expect = 3e-16
Identities = 61/202 (30%), Positives = 99/202 (49%), Gaps = 9/202 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYC 692
PTF++ ++ V EGS E + P P+++W G+ I V I SD
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR--- 62
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L I V K G Y++ A N G+A+ L +K E PP ++ L+SM VRQG V
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-ETAPPNFVQRLQSMTVRQGSQV 121
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L +V G P P + + ++ +++ +GD +S+ I + +D G Y++ A N
Sbjct: 122 RLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYP-EDSGTYSVNATN 180
Query: 810 SEGIAETSAVITVEEPTEENAE 831
S G A ++A + V+ E A+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAK 202
Score = 87.0 bits (206), Expect = 7e-16
Identities = 109/506 (21%), Positives = 193/506 (38%), Gaps = 39/506 (7%)
Query: 598 LIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
++ +A L D G+ + + + L + P K V E +++ C
Sbjct: 6112 VVKDATLQDMGTYVVMVGAARAAAHLTVIEKLRIVVPL-----KDTRVKEQQEVVFNCE- 6165
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
V W F+ EE + D + + ++ D+ +Y L+I + + Y V N G
Sbjct: 6166 VNTEGAKAKW-FRNEEAIFDSSKYIILQKDL-VY--TLRIRDAHLDDQANYNVSLTNHRG 6221
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-- 775
E I E+E +++EPLK + + +SV + V T+ W KN + V
Sbjct: 6222 ENVKSAANLIV--EEEDLRIVEPLKDIETMEKKSVTFWCK-VNRLNVTLKWTKNGEEVPF 6278
Query: 776 -KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPL 834
+ + D H +TI K DEG Y + A + +AE ++ +E PTE
Sbjct: 6279 DNRVSYRVDKYKHMLTI-KDCGFPDEGEYIVTAGQDKSVAE---LLIIEAPTE------- 6327
Query: 835 FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITN 894
F+ ++ TV E +++R ++ WYRN I + DG L+I +
Sbjct: 6328 FVEHLEDQTVTEFDDAVFSCQLSREKA-NVKWYRNGREIKEGKKYKFEKDGSIHRLIIKD 6386
Query: 895 VDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH 954
+ D +Y C + + AR+ ++ V ++ Q E V L
Sbjct: 6387 CRLD-DECEYACGVEDRKSR----ARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNKD 6441
Query: 955 TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKE 1014
V +W N + D +++ EG+ D G + I KD+E L +
Sbjct: 6442 KVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLEL-A 6500
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
P+ QD V + V ++ A+ W ++ E + K +
Sbjct: 6501 AAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTK----TIDTTAEQTS 6556
Query: 1074 LYIRNTSVHDEGEYSCILRDESCTAE 1099
I D+G Y +L+++ AE
Sbjct: 6557 FRILEAKKGDKGRYKIVLQNKHGKAE 6582
Score = 86.2 bits (204), Expect = 1e-15
Identities = 61/211 (28%), Positives = 94/211 (44%), Gaps = 9/211 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F KP + EG + ++V P P+ W G++IV D V I+ D
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1470
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE-PPQVIEPLKSMIVRQGESV 752
++ T G +TVVA NR G +S+ ++L ++ E + P +E LK++ +++G +
Sbjct: 1471 IVPAT---PSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSQL 1527
Query: 753 ILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKV-KDEGVYTLKAE 808
+ + GNP P I W KN+ P K + +G + V +D YT A
Sbjct: 1528 EMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAI 1587
Query: 809 NSEGIAETSAVITVE-EPTEENAEPPLFINR 838
N G T + VE E E E L I R
Sbjct: 1588 NKAGRDTTRCKVNVEVEFAEPEPERKLIIPR 1618
Score = 84.6 bits (200), Expect = 3e-15
Identities = 70/270 (25%), Positives = 116/270 (42%), Gaps = 25/270 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +++L+P G +F + G P+P+I+W+++ ++ + +D TL+
Sbjct: 3193 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEY-TLL 3251
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP-LSDHGSEMTVXXXXXXXXXXXXADI 628
+ E FPEDA +TC AKN G A+++ L VE P + EM V
Sbjct: 3252 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPV--------------- 3296
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
PP + EG +CR V+ + ++W K ++I P + D
Sbjct: 3297 ---YPPAIITPLQDTVTSEGQPARFQCR-VSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT 3352
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ L+I EGTYT VA N G+ S L ++ E + IE M +++
Sbjct: 3353 YQ----LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKE 3408
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKAL 778
S LSA+ G + K N+ ++ L
Sbjct: 3409 FSSSFLSAEEEGLHSAELQLSKINETLELL 3438
Score = 83.0 bits (196), Expect = 1e-14
Identities = 51/198 (25%), Positives = 92/198 (46%), Gaps = 3/198 (1%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
++ G +V L + Y+ P+P+ W+ + +K+ + + S +L+IK + G Y
Sbjct: 21078 VRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKY 21137
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKP-NILEIDSSSINICWDEPENTGNSTIIYYVV 1417
+ L+N V + V L PS P P EI + S+ + WD PE+ G I Y +
Sbjct: 21138 TVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSI 21197
Query: 1418 EYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
E +E T W V ++ +T + NL ++ Y+FR A N +S + +
Sbjct: 21198 EKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL-VSSIIVAKHQ 21256
Query: 1477 TKIQSPTVEKPLKNITTE 1494
+I P + + N+T++
Sbjct: 21257 FRIPGPPGKPVIYNVTSD 21274
Score = 81.8 bits (193), Expect = 2e-14
Identities = 149/701 (21%), Positives = 260/701 (37%), Gaps = 54/701 (7%)
Query: 639 KPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKIT 698
KP++ V EG C P P + WL KG+ + V Y S +I+
Sbjct: 26069 KPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTK----YKSTFEIS 26124
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQV 758
+V+ EG Y+VV N EG+ L I+ V P + V+ E + S +
Sbjct: 26125 SVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPR---VKSPEPRVKSPEA 26181
Query: 759 VGNPR----PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V +P+ P + K P + PT ++ H + + P K+ LKAE S+ IA
Sbjct: 26182 VKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQH-LPVSAPPKI----TQFLKAEASKEIA 26236
Query: 815 E-----TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKL-VARVTRNPVPSITWYR 868
+ S+V+ +E T L N + GT +L + +T +
Sbjct: 26237 KLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEI 26296
Query: 869 NNEIISPSETITQNFDGENIELVITNVD--SEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+ E S+T Q F G+ + + V SE D K S K+ A I
Sbjct: 26297 SGE-GGTSKTNLQ-FMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPIS-S 26353
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHTVSTK-WYHNKKEISGMDHREIIQEGRXXXXX 985
K V LQ + + + T T W + K I+ ++ ++
Sbjct: 26354 KPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLE 26413
Query: 986 XXXXXXXDVGVIKCIVKDQETS-------TMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
D G+ C VK+ S T+ +K+T + + + E+ + A+++
Sbjct: 26414 IHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQE 26473
Query: 1039 EINSETADVVWERDGEI-IKPKKNKYDFEKRGHIRKLYIR---NTSVHDEGEYSCILRDE 1094
EI+ + R EI + K++ + K+ I S E S + +
Sbjct: 26474 EISQKAL-----RSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEI 26528
Query: 1095 SCTAEVT-VVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
+ T++ + V EI +N+G + + + G V+W +G E+ S +
Sbjct: 26529 TKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIA-GATDVKWVLNGVELTNSEEYR 26587
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTV--EEPSINFTLRLPEFIL 1207
+ G Q L I D G +C + G KC LT+ E + P
Sbjct: 26588 YGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQN 26647
Query: 1208 VPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
+ + T EI E + ++ W+K I + ++ +L IR + D +Y
Sbjct: 26648 INEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 26707
Query: 1267 TCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
T + + ++ P + + RE ++ D +L
Sbjct: 26708 TIKAKNFRGQCSATASLMVL-PLVEEPSREVVLRTSGDTSL 26747
Score = 81.0 bits (191), Expect = 4e-14
Identities = 65/245 (26%), Positives = 104/245 (42%), Gaps = 31/245 (12%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
E+ P+FV K +G T +F+ +V G P P+ WF I ++ +D
Sbjct: 1406 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1465
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I P D+G +T VA+N AG +S + L VEA
Sbjct: 1466 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA---------------------- 1503
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
+ + P F +K K + EGS + ++ R P PDI WL + IVP + + I
Sbjct: 1504 ---VEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRI 1560
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + LKI + YT A+N+ G + + ++ EP EP + +
Sbjct: 1561 EGTKGE--AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP----EPERKL 1614
Query: 745 IVRQG 749
I+ +G
Sbjct: 1615 IIPRG 1619
Score = 79.4 bits (187), Expect = 1e-13
Identities = 94/421 (22%), Positives = 165/421 (39%), Gaps = 35/421 (8%)
Query: 1074 LYIRNTSVHDEGEYSCILRDESC----TAEVTVVELPPEIITR-LQNQKVNKGNKAT-FE 1127
+ I+N +G YS + ++E+ T V V+++P + T L + N+ K T F
Sbjct: 10083 MVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFS 10142
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
E G + + + E +T +Q + L Y +
Sbjct: 10143 PEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQG--LIQGKAYFFRIAAENSIG 10200
Query: 1188 ILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW-------------YKKKS 1234
+ E S +R P I VP + E+ T+ +TW Y +S
Sbjct: 10201 MGPFVETSEALVIREP--ITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLES 10258
Query: 1235 VIEDTEKFTLISD--VKKRTLIIRKCTEDDQCEYTCVLLDAKS-------TTKLKVEVVE 1285
+ TEKF +++ + R ++ E D EY ++ T + +
Sbjct: 10259 RLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDEL 10318
Query: 1286 FPPKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
PP + +D+ + I+ G L Y P+P W + + + T + +
Sbjct: 10319 APPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLA 10378
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDE 1403
L K + +D+G Y + +EN+ G V ++D+P PP G + E+ + I W
Sbjct: 10379 LEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKP 10438
Query: 1404 PENTGNSTIIYYVVEYQEIDTTEWISVKNIT-KTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
P + G S I Y++E +E+ W+ V + + KT + L Y FR +A N IS
Sbjct: 10439 PLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGIS 10498
Query: 1463 D 1463
D
Sbjct: 10499 D 10499
Score = 78.6 bits (185), Expect = 2e-13
Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 6/187 (3%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK--SASLTIKKVENTDAG 1356
+K G + L + P P W + + + ID++ S+ ++ K + +D G
Sbjct: 11716 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 11775
Query: 1357 IYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
Y + N G V +LDKP P I+++ S +CWD PE+ G I Y+
Sbjct: 11776 KYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYI 11835
Query: 1417 VEYQEIDTTEWISVKNITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+E E W + T T++ L + Y FR A N++ TE VI
Sbjct: 11836 LEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKI---GTGPPTESKPVIA 11892
Query: 1476 ETKIQSP 1482
+TK P
Sbjct: 11893 KTKYDKP 11899
Score = 77.0 bits (181), Expect = 7e-13
Identities = 124/586 (21%), Positives = 227/586 (38%), Gaps = 62/586 (10%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
+K K V E EC + P + WL G EI E + ++ +H L
Sbjct: 2839 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ----LI 2893
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
I N YT V N + A+L + P + LK + + +++
Sbjct: 2894 IMNTSTEDSAEYTFVCGNDQVSATLTVT---------PIMITSMLKDINAEEKDTITFEV 2944
Query: 757 QVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
V + W KN +K+ ++ THS+ I + D YT A G
Sbjct: 2945 -TVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNI-RNVHFGDAADYTFVA----GK 2998
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A ++A + VE E F ++I V EK V+ P ++ W ++++ +
Sbjct: 2999 ATSTATLYVEARHIE------FRKHIKDIKVLEKKRAMFECEVSE-PDITVQWMKDDQEL 3051
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ I + L+I + D+G Y VA + A++ ++ V ++
Sbjct: 3052 QITDRIKIQKEKYVHRLLIPSTRMS-DAGKYTVVAGGNVST----AKLFVEGRDVR-IRS 3105
Query: 934 LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGM--DHREIIQEGRXXXXXXXXXX 990
++K + E + ++E + + V WY + EI+ + + + E R
Sbjct: 3106 IKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETR 3165
Query: 991 XXDVGVIKCIV-KDQETSTMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVV 1048
D G + +++ + T+ V P+ +++LQ V+ K V +
Sbjct: 3166 QSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKIS 3225
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE------SCTAEVTV 1102
W ++ +++ K F G L + D Y+C +++ S + V V
Sbjct: 3226 WYKEEQLLSTGF-KCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEV 3284
Query: 1103 VEL----------PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
E+ PP IIT LQ+ ++G A F+ ++ D V W+ +I+ S
Sbjct: 3285 PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFF 3344
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEY----SCEVGNSKCTAILTVEEP 1194
++T +L+I + +D G Y S VG TA L++E P
Sbjct: 3345 RMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAP 3390
Score = 76.2 bits (179), Expect = 1e-12
Identities = 64/231 (27%), Positives = 104/231 (45%), Gaps = 35/231 (15%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ--DFQMYYDDDN 564
+ AP F + L+ +GST FE + G+P P+++WFR +I S Q+ + D
Sbjct: 3 TQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
A L I V ++G ++ A N +G A+ST +E+ V
Sbjct: 63 -AKLTIPAVTKANSGRYSLKATNGSGQATST-------------AELLVKA--------- 99
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
E PP F ++ ++ V +GS + L+ R+ IP P + + G EI + ++
Sbjct: 100 -----ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQ 154
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP 735
E D++ L I GTY+V A N G A+ L ++ GE+E P
Sbjct: 155 EGDLYS----LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ-GEEEVP 200
Score = 76.2 bits (179), Expect = 1e-12
Identities = 55/212 (25%), Positives = 94/212 (44%), Gaps = 9/212 (4%)
Query: 1288 PKIVDYEREYR----IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
P IV++ EY IK G + + Q P P W + I+K + + + S
Sbjct: 21458 PPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGST 21517
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP-PGKPNILEIDSSSINICWD 1402
SL ++ G+Y + +N G A E+ V + D P G I + + WD
Sbjct: 21518 SLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWD 21577
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQ--TSIQNLKTNSSYRFRAYAVNEVD 1460
P N G + I +Y++E +E W +++ + Q T+I+ + N Y+FR AVN+
Sbjct: 21578 APLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGN-EYQFRVSAVNKFG 21636
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNIT 1492
+ ++ I+ T +P + +P NIT
Sbjct: 21637 VGRPLDSDPVVAQIQYTVPDAPGIPEP-SNIT 21667
Score = 73.7 bits (173), Expect = 6e-12
Identities = 41/112 (36%), Positives = 60/112 (53%), Gaps = 2/112 (1%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
++P P E P + L+ T +G +F+C+V G +++W+ + IKPS
Sbjct: 3283 EVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPS 3341
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ F+M +D L I E +PED GT+T VA NA G SST L +EAP S
Sbjct: 3342 RFFRMTQFEDTYQ-LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPES 3392
Score = 73.3 bits (172), Expect = 9e-12
Identities = 54/205 (26%), Positives = 92/205 (44%), Gaps = 13/205 (6%)
Query: 476 DENNYTQYLQ-KKLNEKIDKL---PVFE-KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFE 530
+E ++ LQ K+NE ++ L PV+ K SE++ PIF++++ G
Sbjct: 3418 EEGLHSAELQLSKINETLELLSESPVYSTKFDSEKEGTGPIFIKEVSNADISMGDVATLS 3477
Query: 531 CQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
V G P+P+I WF ++ PS D++ +D D+ +L+I ED G +TC+A N G
Sbjct: 3478 VTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDD-HSLIILFTKLEDEGEYTCMASNDYG 3536
Query: 591 FASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEG-IPPTFSKKPKAQYVDEGS 649
+ L + + H T + L G PP F K+ K +G
Sbjct: 3537 KTICSAYLKINSKGEGHKDTET------ESAVAKSLEKLGGPCPPHFLKELKPIRCAQGL 3590
Query: 650 DILLECRLVAIPEPDIAWLFKGEEI 674
+ E +V P P + W + +++
Sbjct: 3591 PAIFEYTVVGEPAPTVTWFKENKQL 3615
Score = 72.9 bits (171), Expect = 1e-11
Identities = 80/324 (24%), Positives = 121/324 (37%), Gaps = 30/324 (9%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
DEG+ + V + E + E I IE +M + S +
Sbjct: 3364 DEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHS 3423
Query: 706 GTYTVVAVNREGE--ASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILSAQVVGN 761
+ +N E + P+ EKE P I+ + + + G+ LS V+G
Sbjct: 3424 AELQLSKINETLELLSESPVYSTKFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGI 3483
Query: 762 PRPTITWCKNN---KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P+P I W N P DGD HS+ IL K ++DEG YT A N G SA
Sbjct: 3484 PKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILFTK-LEDEGEYTCMASNDYGKTICSA 3542
Query: 819 VITVEEPTEENAE------------------PPLFINRFQEITVKEKGTIKLVARVTRNP 860
+ + E + + PP F+ + I + V P
Sbjct: 3543 YLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEP 3602
Query: 861 VPSITWYRNNEIISPS--ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P++TW++ N+ + S TI N +G I N DSG Y C A N G+S+
Sbjct: 3603 APTVTWFKENKQLCTSVYYTIIHNPNGSG--TFIVNDPQREDSGLYICKAENMLGESTCA 3660
Query: 919 ARVTIDVEKVTFVKHLQKSYETEE 942
A + + +E K+ T E
Sbjct: 3661 AELLVLLEDTDMTDTPCKAKSTPE 3684
Score = 72.9 bits (171), Expect = 1e-11
Identities = 64/217 (29%), Positives = 88/217 (40%), Gaps = 28/217 (12%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
EG P F K+ + G L ++ IP+P I W F G + P + + D H
Sbjct: 3453 EGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDH 3512
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT---GEKE------------- 733
L I K EG YT +A N G+ LKI + G K+
Sbjct: 3513 S----LIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEK 3568
Query: 734 -----PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV--KALPTKSDGDT 786
PP ++ LK + QG I VVG P PT+TW K NK + T
Sbjct: 3569 LGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPN 3628
Query: 787 HSIT-ILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
S T I+ + +D G+Y KAEN G + +A + V
Sbjct: 3629 GSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3665
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 1/96 (1%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
++ P FV++L+ GS V+ + +V G P P + ++R A I+ S DFQ+ + D +
Sbjct: 100 ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD-L 158
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+L+I E +PED+GT++ A N+ G A+ST EL+V+
Sbjct: 159 YSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 72.1 bits (169), Expect = 2e-11
Identities = 64/298 (21%), Positives = 122/298 (40%), Gaps = 11/298 (3%)
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTL 1244
TA VE P I+ + + I+V A L ++ + L + W + IE++ + +
Sbjct: 17118 TAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEI 17177
Query: 1245 ISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFP-PKIVDYEREYRIKR 1301
+ K LI++ D +Y + + + V+V++ P P +
Sbjct: 17178 KNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSE 17237
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
+T Q ++V + + T + + + SL + K+ + ++++
Sbjct: 17238 KCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIM 17297
Query: 1362 LENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
N G + + +L K P PP + I S+ +CW+ P++ G S II Y+
Sbjct: 17298 AVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 17357
Query: 1417 VEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
VE ++ WI + + IT + + L + Y FR A N + + S T YYK
Sbjct: 17358 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYK 17415
Score = 71.7 bits (168), Expect = 3e-11
Identities = 72/330 (21%), Positives = 133/330 (40%), Gaps = 40/330 (12%)
Query: 646 DEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+EG + C++ + + W F ++ E + E + ++L + ++ K
Sbjct: 25083 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGV----AILYVKDITKLD 25138
Query: 705 EGTYTVVAVNREGEASLPIVLKIK------------TGEK------------EPPQVIEP 740
+GTY VN GE S L +K T +K PP+ P
Sbjct: 25139 DGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLP 25198
Query: 741 LKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV------KALPTKSDGDTHSITILKP 794
L + GE+V + +P P +TW K+ + + K +SD + +TI
Sbjct: 25199 LYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTI-NS 25257
Query: 795 KKVKDEGVYTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKL 852
D+ YT+ A N E + +T+ P ++ P+F +E ++
Sbjct: 25258 VTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCF 25317
Query: 853 VARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSA 912
RV+ P P++ W ++ + +S I +G + + D+G Y+ A+N+A
Sbjct: 25318 EIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTA 25377
Query: 913 GKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
G +S + + VE++ + K KS E E
Sbjct: 25378 GSTS--CQAHLQVERLRYKKQEFKSKEEHE 25405
Score = 69.3 bits (162), Expect = 1e-10
Identities = 54/172 (31%), Positives = 90/172 (52%), Gaps = 16/172 (9%)
Query: 678 ENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---P 734
E S+ ES + C+ + +T + QE + V A N +G++ P VL + K+
Sbjct: 17760 EKWSIVAESKV---CNAV-VTGLSSGQEYQFRVKAYNEKGKSD-PRVLGVPVIAKDLTIQ 17814
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P + P + ++ GE + + V+G PRP I+W K+ +P+K + +T + T+L
Sbjct: 17815 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHI 17874
Query: 795 KK-VKDE-GVYTLKAENSEGIA-ETSAVITVEEPTEENAEPPLFINRFQEIT 843
K+ KD+ G YT+ A NS G A E +VI +E+P PP+ RF E++
Sbjct: 17875 KEGNKDDFGKYTVTATNSAGTATENLSVIVLEKP-----GPPVGPVRFDEVS 17921
Score = 68.5 bits (160), Expect = 2e-10
Identities = 40/163 (24%), Positives = 79/163 (48%), Gaps = 12/163 (7%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASL-----TIKKVENTDAGIYKLRLENNCGHA 1369
P+ + + + I++KC+ + + SA++ T+ ++ + I+++R EN G
Sbjct: 11823 PEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTG 11882
Query: 1370 DVEMNVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
+ ++ DKP P P + ++ + + W+ PE G +I Y +E +E +
Sbjct: 11883 PPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHS 11942
Query: 1425 TEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
T W+ V I + + +QNL + Y+FR A NE+ I + S
Sbjct: 11943 TRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPS 11985
Score = 68.5 bits (160), Expect = 2e-10
Identities = 75/299 (25%), Positives = 130/299 (43%), Gaps = 15/299 (5%)
Query: 319 EAAKVKKQVF--VPPKLPDVEKTELEQPLFSYEDIVESK-KDENEIIQEKQTLEELPKED 375
EA KV Q + P+ V + E+ Q E+I S+ K + ++ +++ + L E+
Sbjct: 26451 EAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEE 26510
Query: 376 VPEQYTITPRKSSAQKIDEIVDEVTIKKRLNP-FEIFYTPVEVRCGDTVFAVYSYVAETD 434
V + + KS + + + + R + + F T + + G + + TD
Sbjct: 26511 VKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATD 26570
Query: 435 EAINLVEGERLYILDTSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDK 494
++ G L T+++++ Y + A + DE T K E I K
Sbjct: 26571 VKW-VLNGVEL----TNSEEYRYGVSGSDQTLTIKQASH-RDEGILTCI--SKTKEGIVK 26622
Query: 495 LPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ 554
++ S+E S AP F+ + R ++ +G V F C++ G P P+I WF+ I S
Sbjct: 26623 CQ-YDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISS 26681
Query: 555 DFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTV 613
+ + NV +L IR D+G +T AKN G S+T L+V PL + S V
Sbjct: 26682 NVSI-SRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV-LPLVEEPSREVV 26738
Score = 67.3 bits (157), Expect = 6e-10
Identities = 69/297 (23%), Positives = 126/297 (42%), Gaps = 18/297 (6%)
Query: 1187 AILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLI 1245
A+ T E P I ++L + V A T L + + +TW K +++ ++ T+
Sbjct: 7184 AVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIE 7243
Query: 1246 SDVKKRTLIIRKCTEDDQCEYT--CVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGS 1303
+ KK T+ I D Y V + ++T ++V V++ P ++ I +
Sbjct: 7244 NVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFD----ITDVT 7299
Query: 1304 DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT----KPSIDSKSASLTIKKVENTDAGIYK 1359
+ + L+ + I N + ++ + K S K + K+ I++
Sbjct: 7300 NESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFR 7359
Query: 1360 LRLENNCGHAD-VEMN-VTILDKPSPPGKPNILE---IDSSSINICWDEPENTGNSTIIY 1414
+ EN G + V+ + +T + PPG P LE I ++ + W EP++ G S I
Sbjct: 7360 VAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITG 7419
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
Y VE + DT +W+ + T+ ++ L YRFR A N S++TE
Sbjct: 7420 YWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTE 7476
Score = 67.3 bits (157), Expect = 6e-10
Identities = 62/257 (24%), Positives = 110/257 (42%), Gaps = 16/257 (6%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEF 1286
++W K ++++E K TL I+ ++ +YT +L +A + + V+
Sbjct: 21098 ISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITL 21157
Query: 1287 -PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK--CKHTKPSIDSKSA 1343
PP + + V L D P+ N + I+K T + S
Sbjct: 21158 GPPSKPKGPIRFDEIKADSVILSWD---VPEDNGGGEITCYSIEKRETSQTNWKMVCSSV 21214
Query: 1344 SLTIKKVEN--TDAGI-YKLRLENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSS 1395
+ T KV N DA +++R EN G + ++ I+ K P PPGKP I + S
Sbjct: 21215 ARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSD 21274
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKTQTSIQNLKTNSSYRFRA 1453
+++ WD P G S + + VE +E ++ W ++ I+ + L Y+FR
Sbjct: 21275 GMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRV 21334
Query: 1454 YAVNEVDISDASETTEY 1470
YA N +S S+ +++
Sbjct: 21335 YAENSAGLSSPSDPSKF 21351
Score = 66.1 bits (154), Expect = 1e-09
Identities = 37/104 (35%), Positives = 56/104 (53%), Gaps = 2/104 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE +++ F +++ +G V F C++ GYP P+I W++ IK + +QM +
Sbjct: 1238 SESEAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQ 1297
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE--APL 604
D A+L I V PED G +T A N G A + +L VE APL
Sbjct: 1298 DGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPL 1341
Score = 65.7 bits (153), Expect = 2e-09
Identities = 54/185 (29%), Positives = 83/185 (44%), Gaps = 9/185 (4%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNK-YDFEKRGHIRKL 1074
P F + LQ V E A E I+ +V W RDG++I KL
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1075 YIRNTSVHDEGEYSCILRDES----CTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEI 1128
I + + G YS + S TAE+ V PP + RLQ+ V +G++ ++
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 1129 ELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
+T +V++++DG+EIQ S Q++ +G L I + +D+G YS NS A
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 1188 ILTVE 1192
T E
Sbjct: 186 TSTAE 190
Score = 64.9 bits (151), Expect = 3e-09
Identities = 64/281 (22%), Positives = 114/281 (40%), Gaps = 14/281 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIEL-TKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P I R+++ +V G F + + +K A V+W+ +G E+Q S+ I T L+I
Sbjct: 25877 PRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEI 25936
Query: 1166 YDCDLDDAGEYSCEVGNSKCTA--ILTVEEPSINFTLRLPE--FILVPANTDAYLTVEIP 1221
DC DD+G Y N K A T++ ++T + VP + LT
Sbjct: 25937 LDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELT---R 25993
Query: 1222 DETLDVTWYKKKSVIEDTEKFTLI-SDVKKRTLIIRKCTEDDQCEYTCVLLDAKS----T 1276
E V+ +KK S +E + + S + + + E L+ KS +
Sbjct: 25994 TEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKS 26053
Query: 1277 TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
T K++ +I+ R + G D P P W+ +++ +
Sbjct: 26054 TTRKIKTT-LAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQV 26112
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ ++ I V+ +D G Y + +EN+ G + E +TI
Sbjct: 26113 TTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTI 26153
Score = 64.9 bits (151), Expect = 3e-09
Identities = 80/400 (20%), Positives = 138/400 (34%), Gaps = 13/400 (3%)
Query: 1282 EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
E + P IV ++ + S V P+P W + K I + K S D
Sbjct: 26349 EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKG 26408
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD-KPSPPGKPNILEIDSSSINIC 1400
L I K + +D+G+Y ++N+ G +TI K + K + + +
Sbjct: 26409 GFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKK 26468
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE-- 1458
E + ++ E + E +++K + +K +++ V+E
Sbjct: 26469 AVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEI 26528
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
S ASE + IK Q E + ++ + GV YR
Sbjct: 26529 TKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRY 26588
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK--PVITIS 1576
G T + CI+ G V+ + + ++
Sbjct: 26589 GVSGSDQTLTIKQASHRDEGILT--------CISKTKEGIVKCQYDLTLSKELSDAPAFI 26640
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELK 1636
++ Q G L T I G P PE+ W+KN + +I+ + I+
Sbjct: 26641 SQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNAS 26700
Query: 1637 RSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
S S KYTI+A N G S +L V +P V++R
Sbjct: 26701 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLR 26740
Score = 64.9 bits (151), Expect = 3e-09
Identities = 84/402 (20%), Positives = 149/402 (37%), Gaps = 60/402 (14%)
Query: 541 ITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ W + S++++ Y + TL I++ D G TC++K G +L +
Sbjct: 26571 VKWVLNGVELTNSEEYR-YGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTL 26629
Query: 601 EAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAI 660
LSD P F +P++Q ++EG ++L C +
Sbjct: 26630 SKELSD--------------------------APAFISQPRSQNINEGQNVLFTCEISGE 26663
Query: 661 PEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEAS 720
P P+I W I N+S++ +++ L+I N G YT+ A N G+ S
Sbjct: 26664 PSPEIEWFKNNLPISISSNVSISRSRNVYS----LEIRNASVSDSGKYTIKAKNFRGQCS 26719
Query: 721 LPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPT 780
L + P V EP + +++R L G+ +K + +
Sbjct: 26720 ATASLMVL------PLVEEPSREVVLRTSGDTSLQ----GSFSSQSVQMSASKQEASFSS 26769
Query: 781 KSDGDTHSITILKPKKVKDEGVYTLKAE----NSEGIAETSAVITVEEPTEENAE----- 831
S S+T +K + + + +++ +S S + +E T + +
Sbjct: 26770 FSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRG 26829
Query: 832 -PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE- 889
PP +I++ E + + T P P +TW I E F EN +
Sbjct: 26830 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQE--QGRFHIENTDD 26887
Query: 890 ---LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
L+I +V + D G Y N G S A V I + +
Sbjct: 26888 LTTLIIMDVQKQ-DGGLYTLSLGNEFGSDS--ATVNIHIRSI 26926
Score = 63.7 bits (148), Expect = 7e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 2/110 (1%)
Query: 495 LPVFEKPTSE-EQSM-APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKP 552
+P F+ E SM AP E+++ + GS F +V G P P+ W++ I+
Sbjct: 2015 IPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIER 2074
Query: 553 SQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
S Y+ +DNV LVIR+V ED+ + A N AG SS L+V+A
Sbjct: 2075 SDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2124
Score = 63.7 bits (148), Expect = 7e-09
Identities = 61/206 (29%), Positives = 93/206 (45%), Gaps = 15/206 (7%)
Query: 1012 VKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHI 1071
+KE P L D +E D+ L I + +V W + +++ P K+ + +
Sbjct: 4238 IKEDGPMIHTPLVDTVSEEGDIVHLTTSITN-AKEVNWYFENKLV-PSDEKFKCLQDQNT 4295
Query: 1072 RKLYIRNTSVHD-EGEYSC-ILRDESCTA---EVTVVELPPEIITR-LQNQKVNKGNKAT 1125
L I + D +GEY C L D TA ++TVV+ +I R ++ +V G+ A
Sbjct: 4296 YTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAK 4355
Query: 1126 FEIELTKG-DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EV 1180
F E+ + +WFK G EI S+ + L+I + D GEY+C E
Sbjct: 4356 FTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEY 4415
Query: 1181 GNSKCTAILTVEEPSINFTLR--LPE 1204
G+ CTA LTV P +R LPE
Sbjct: 4416 GSVSCTATLTVTVPGGEKKVRKLLPE 4441
Score = 62.9 bits (146), Expect = 1e-08
Identities = 62/302 (20%), Positives = 121/302 (40%), Gaps = 13/302 (4%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVV 1284
V+W+K ++ +++ T+ +D L + K D YT L + +T + V+V+
Sbjct: 7921 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVI 7980
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P D + K +T P +++ + + + S
Sbjct: 7981 GLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLS 8040
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHAD-VEMNVTIL--DKPSPPGKPNILEIDS---SSIN 1398
T+K + ++++ N G + +E+ ++ D PP P +E+ + ++
Sbjct: 8041 WTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMT 8100
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQT-SIQNLKTNSSYRFRAYAV 1456
I W P G S I+ Y++E W +++ T + + L+ Y+FR A
Sbjct: 8101 ITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAE 8160
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY 1516
N IS+ S T K + I +P V ++ + ++I L G P P +TW
Sbjct: 8161 NAAGISEPSRATPPTKAV--DPIDAPKVIL-RTSLEVKRGDEIALDASISGSPYPTITWI 8217
Query: 1517 RD 1518
+D
Sbjct: 8218 KD 8219
Score = 61.3 bits (142), Expect = 4e-08
Identities = 82/345 (23%), Positives = 146/345 (42%), Gaps = 28/345 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F ++ + V S+ L C++ P+P + W +G+EI+ D + I+ Y
Sbjct: 24431 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIAD-GLKYRIQEFKGGYHQ 24489
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK-EPPQVIEPLKSMIVRQGESV 752
++ I +V Y V A N+ G S L+++ K P+ +E + ++ +GE V
Sbjct: 24490 LI-IASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVV 24548
Query: 753 ILSAQVVGNPRPTITWCK------NNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ G P P ITW K NN + + T+S S+ + KD G Y +
Sbjct: 24549 SIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRS---FTSLVFPNGVERKDAGFYVVC 24605
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLV-ARVTRNPVPSIT 865
A+N GI + TVE + +PP R +++ + ++ L + IT
Sbjct: 24606 AKNRFGIDQK----TVELDVADVPDPP----RGVKVSDVSRDSVNLTWTEPASDGGSKIT 24657
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTI 923
Y + + +E + + N+ + S ++ +A N G K S + TI
Sbjct: 24658 NYIVEKCATTAERWLRVGQARETRYTVINLFGK-TSYQFRVIAENKFGLSKPSEPSEPTI 24716
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEIS 968
E T + + E +E + V + + SH+ STK + K I+
Sbjct: 24717 TKEDKT--RAMNYDEEVDETREVSM-TKASHS-STKELYEKYMIA 24757
Score = 60.9 bits (141), Expect = 5e-08
Identities = 60/235 (25%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++++ T G Q CQ+ G P P I W+R + S+ ++M D TL
Sbjct: 24035 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKM-SSDGRTHTL 24093
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
+ ED G +TC+A N G ++++L+++A H
Sbjct: 24094 TVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFH--------------------- 24132
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
P + K K Y GS + L + P P + W F G++++ + ++ IE+
Sbjct: 24133 -----PGYPLKEK-YYGAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQNSE-NITIENTE 24184
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPL 741
H V+K +K G Y V N G +A L + ++ K + P VIE L
Sbjct: 24185 HYTHLVMKNVQ-RKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEAL 24238
Score = 60.5 bits (140), Expect = 6e-08
Identities = 48/209 (22%), Positives = 84/209 (40%), Gaps = 10/209 (4%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ G P K+ K G L C++V P PDI W G+E++ ++ +
Sbjct: 24030 LTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGR 24089
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV- 746
H L + ++ EG YT +A N GE L ++ + P PLK
Sbjct: 24090 TH----TLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGY--PLKEKYYG 24143
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDE---GVY 803
G ++ L +G P P +TW K ++ + +T T L K V+ + G Y
Sbjct: 24144 AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKY 24203
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEP 832
++ N G + + +++ ++ P
Sbjct: 24204 KVQLSNVFGTVDAILDVEIQDKPDKPTGP 24232
Score = 60.1 bits (139), Expect = 9e-08
Identities = 61/251 (24%), Positives = 95/251 (37%), Gaps = 34/251 (13%)
Query: 480 YTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRP 539
Y + KK+ + D + + E+P P F L K G V+F + +P P
Sbjct: 25171 YCRRTMKKIKRRTDTMRLLERP--------PEFTLPLYNKTAYVGENVRFGVTITVHPEP 25222
Query: 540 QITWFRQTAIIKPSQDFQMY--YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTE 597
+TW++ IKP + + Y D + L I V +D +T VA+N G S +
Sbjct: 25223 HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 25282
Query: 598 LIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
L V L ++ T + P F + EG + E R+
Sbjct: 25283 LTV--TLHPPPTDST-------------------LRPMFKRLLANAECQEGQSVCFEIRV 25321
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
IP P + W G+ + NI + I + Y L I + G Y V A N G
Sbjct: 25322 SGIPPPTLKWEKDGQPLSLGPNIEI-IHEGLDYY--ALHIRDTLPEDTGYYRVTATNTAG 25378
Query: 718 EASLPIVLKIK 728
S L+++
Sbjct: 25379 STSCQAHLQVE 25389
Score = 60.1 bits (139), Expect = 9e-08
Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 20/166 (12%)
Query: 1047 VVWERDGEIIKPKKN--KYDFEKRGHIRKLYIRNTSVHDEGEYSCILR----DESCTAEV 1100
V W + G+ IKP N KY FE + +L I + + D+ EY+ + R ++SC A++
Sbjct: 25224 VTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKL 25283
Query: 1101 TVVELPPEIITRLQ--------NQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNH 1151
TV PP + L+ N + +G FEI ++ ++W KDG + +
Sbjct: 25284 TVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPN 25343
Query: 1152 IQLTIDG-KKQKLKIYDCDLDDAGEY----SCEVGNSKCTAILTVE 1192
I++ +G L I D +D G Y + G++ C A L VE
Sbjct: 25344 IEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 25389
Score = 58.8 bits (136), Expect = 2e-07
Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 16/157 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA-----SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
ITN+ + +E + VVAVN +G + ++PIV K E P V S V+ G+
Sbjct: 16693 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIE---PDVKPAFSSYSVQVGQD 16749
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV-KDE-GVYTLKAEN 809
+ + + G P+PTITW K+ P+K + D+ +T L K+ KD+ G Y + N
Sbjct: 16750 LKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVAN 16809
Query: 810 SEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVK 845
G S ++T+++P +PP +F +++ +
Sbjct: 16810 VVGQKTASIEIVTLDKP-----DPPKGPVKFDDVSAE 16841
Score = 58.8 bits (136), Expect = 2e-07
Identities = 65/275 (23%), Positives = 110/275 (40%), Gaps = 31/275 (11%)
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSY-RFRAYAVNEVDISDASETTEYY-- 1471
Y + Y+ D + VK+ITK K + Y +YA E+ + E +YY
Sbjct: 25118 YEITYE--DGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYA--ELFVKGVREVYDYYCR 25173
Query: 1472 KVIKETKIQSPTVEK---------PLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ +K+ K ++ T+ PL N T E++ P+P VTWY+ G+K+
Sbjct: 25174 RTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKI 25233
Query: 1523 KTA----KATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGE--VETSCVVGIQQKPVI 1573
K K T+E+ Y +A N +GE + V + P
Sbjct: 25234 KPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTD 25293
Query: 1574 TISNEDIKQ-----KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KT 1627
+ K+ + + G + GIPPP + W K+G L I +
Sbjct: 25294 STLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDY 25353
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ I++ + Y + A+NTAG++S + L+V
Sbjct: 25354 YALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 25388
Score = 58.8 bits (136), Expect = 2e-07
Identities = 36/128 (28%), Positives = 56/128 (43%), Gaps = 2/128 (1%)
Query: 476 DENNYTQYLQKKLNEKI--DKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQV 533
D+ YT + K E KL V P + ++ P+F L +G +V FE +V
Sbjct: 25262 DDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRV 25321
Query: 534 EGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFAS 593
G P P + W + + + ++ ++ + L IR+ PED G + A N AG S
Sbjct: 25322 SGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTS 25381
Query: 594 STTELIVE 601
L VE
Sbjct: 25382 CQAHLQVE 25389
Score = 58.4 bits (135), Expect = 3e-07
Identities = 45/148 (30%), Positives = 70/148 (47%), Gaps = 8/148 (5%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---PPQVIEPLKSMIVRQGES 751
L +T +K+ ++ + V A N G SLP + KE PP+++ P + + ++ G+
Sbjct: 12361 LVVTGLKEGKKYKFRVAARNAVG-VSLPREAEGVYEAKEQLLPPKILMP-EQITIKAGKK 12418
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKS--DGDTHSITILKPKKVKDEGVYTLKAEN 809
+ + A V G P PT W K V + D+ SI I+K KD G Y+L AEN
Sbjct: 12419 LRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAEN 12478
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFIN 837
S G +T + V +PP I+
Sbjct: 12479 SSG-TDTQKIKVVVMDAPGPPQPPFDIS 12505
Score = 58.0 bits (134), Expect = 3e-07
Identities = 59/275 (21%), Positives = 104/275 (37%), Gaps = 16/275 (5%)
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE--NAEPPLFINRFQEITVKEKGT 849
LKP + K+E +SE E A + ++E + P+ + +E
Sbjct: 4207 LKPSEEKEES-------SSESGTEEVATVKIQEAEGGFIKEDGPMIHTPLVDTVSEEGDI 4259
Query: 850 IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS 909
+ L +T + WY N+++ E D LVI V++E G+Y C A
Sbjct: 4260 VHLTTSITN--AKEVNWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEAL 4317
Query: 910 NSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSHTVSTKWYHNKKEI 967
N +GK++ A++T+ +K + E G C Q++ V +W+ +EI
Sbjct: 4318 NDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREI 4377
Query: 968 SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRKLQD 1025
D I D G C ++ S + T+P +K++
Sbjct: 4378 YESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRK 4437
Query: 1026 FEVKEKDVAILEVEINSETADVVWERDGEIIKPKK 1060
+ K EV + S E + + ++PKK
Sbjct: 4438 LLPERKPEPKEEVVLKSVLRKRPEEEEPK-VEPKK 4471
Score = 57.6 bits (133), Expect = 5e-07
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 7/197 (3%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------ATYENRX 1533
Q+PT +PL+++ G P P+V+W+RDG+ + T+ + + R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDEWLV 1592
Y A N G+ ++ + ++ + + ++ + G + +
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ GIP P V +Y++G ++++ ++ I+ + + I E S Y++ A+N+ G
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 1653 TSSVEVTLKVYDKPSKP 1669
++ L V + P
Sbjct: 184 RATSTAELLVQGEEEVP 200
Score = 57.6 bits (133), Expect = 5e-07
Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E+ + AP F+ K + +G +V F CQV G P+P + W + + +++
Sbjct: 1025 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKV 1084
Query: 559 YYD-DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
Y+ LVI F +DAG +T V +N G S++ L+ EA
Sbjct: 1085 SYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEA 1129
Score = 57.2 bits (132), Expect = 6e-07
Identities = 26/91 (28%), Positives = 48/91 (52%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++L+P G FE V G P P +TWF++ + S + + ++ + T +
Sbjct: 3575 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFI 3634
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ + ED+G + C A+N G ++ EL+V
Sbjct: 3635 VNDPQREDSGLYICKAENMLGESTCAAELLV 3665
Score = 57.2 bits (132), Expect = 6e-07
Identities = 42/167 (25%), Positives = 69/167 (41%), Gaps = 5/167 (2%)
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC-TEDDQCEYTCVLLD- 1272
+LT I + +V WY + ++ EKF + D TL+I K TED Q EY C L+
Sbjct: 4261 HLTTSITNAK-EVNWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALND 4319
Query: 1273 -AKSTTKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
K+ T K+ VV+ ++ + E + G + Q+ P +W + I +
Sbjct: 4320 SGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE 4379
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+SL I + + D G Y + N G +T+
Sbjct: 4380 SDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4426
Score = 56.8 bits (131), Expect = 8e-07
Identities = 44/153 (28%), Positives = 76/153 (49%), Gaps = 10/153 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA----SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ N+ + +E T+ V+AVN G + S P+++K +T E K +I + G+++
Sbjct: 14527 VRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNI 14586
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAENS 810
+ V+G P+PT+TW K ++ +K + T + TIL + D G Y L A N
Sbjct: 14587 KVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNI 14646
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G E VIT++ + PP +F E++
Sbjct: 14647 VG--EVGDVITIQ--VHDIPGPPTGPIKFDEVS 14675
Score = 56.4 bits (130), Expect = 1e-06
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 5/136 (3%)
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A+ + V P E PP ++ + +TV E ++ L ++ P P++TWYR + I
Sbjct: 878 AKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQI 937
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
S F L+I +E DSG + C A N AG S + + V + F K
Sbjct: 938 ESSIDFQITFQSGIARLMIREAFAE-DSGRFTCSAVNEAGTVSTSCYLAVQVSE-EFEKE 995
Query: 934 ---LQKSYETEEGKTV 946
+ + + TEE + V
Sbjct: 996 TTAVTEKFTTEEKRFV 1011
Score = 56.4 bits (130), Expect = 1e-06
Identities = 87/445 (19%), Positives = 153/445 (34%), Gaps = 33/445 (7%)
Query: 540 QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELI 599
++TW++ +K + FQ +Y D L I + D G + C G + + + +
Sbjct: 26251 EVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFM 26310
Query: 600 VEAPLSDHGSEMTVXXXXXXXXXXXXADILE----GIPPTFSKKP----KAQYVDEGSDI 651
+A S H + + + P S KP Q SD
Sbjct: 26311 GQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDS 26370
Query: 652 LLECRLVAI--PEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYT 709
+ + + A P P W G+ I + + D + L+I G YT
Sbjct: 26371 VAKFAVKATGEPRPTAIWTKDGKAIT--QGGKYKLSEDKGGF--FLEIHKTDTSDSGLYT 26426
Query: 710 VVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNP-RPTITW 768
N G S L IK + Q + K+ + + ++ ++ R
Sbjct: 26427 CTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIK 26486
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL-KAENSEGIAETSAVITVEEPTE 827
K + L K + +L ++VK +L K+ E I +TS E
Sbjct: 26487 MSEAKSQEKLALKEEAS----KVLISEEVKKSAATSLEKSIVHEEITKTS---QASEEVR 26539
Query: 828 ENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGEN 887
+AE F ++++ E + L A + + W N ++ SE G +
Sbjct: 26540 THAEIKAFST---QMSINEGQRLVLKANIA--GATDVKWVLNGVELTNSEEYRYGVSGSD 26594
Query: 888 IELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
L I S D G C++ G K + ++ ++ +S EG+
Sbjct: 26595 QTLTIKQA-SHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQN 26653
Query: 946 VILECQTSHTVS--TKWYHNKKEIS 968
V+ C+ S S +W+ N IS
Sbjct: 26654 VLFTCEISGEPSPEIEWFKNNLPIS 26678
Score = 56.0 bits (129), Expect = 1e-06
Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 1/108 (0%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMY 559
P S+ AP F E+LR + S C+V G+P+P + W+RQ II +++
Sbjct: 24422 PKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQ 24481
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDH 607
L+I V +DA + A N G S T L VE P H
Sbjct: 24482 EFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIH 24529
Score = 56.0 bits (129), Expect = 1e-06
Identities = 70/320 (21%), Positives = 130/320 (40%), Gaps = 32/320 (10%)
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYE-------REYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
L + T++ K EV+ P +D+ R +R+ G + +++ Q+ P +W
Sbjct: 25853 LKTQKTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYH 25912
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD--VEMNVTILDKP 1381
N +++ + S +L I D+G Y+ N G A ++VT D
Sbjct: 25913 NGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYT 25972
Query: 1382 SPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS----VKN-ITKT 1436
+ + E+ S PE T T Y V +++ E S VK+ +T+T
Sbjct: 25973 TYASQRRDEEVPRSVF------PELT--RTEAYAVSSFKKTSEMEASSSVREVKSQMTET 26024
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
+ S+ + + ++S ++ A+ E + + S T + +T + + + KP +++T
Sbjct: 26025 RESLSSYEHSASAEMKSAALEEKSLEEKSTTRKI-----KTTLAARILTKP-RSMTVYEG 26078
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIA 1552
E +C G P P VTW R G+ L T+ T + + Y +
Sbjct: 26079 ESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVV 26138
Query: 1553 FNDHGEVETSCVVGIQQKPV 1572
N G+ E + IQ+ V
Sbjct: 26139 ENSEGKQEAEFTLTIQKARV 26158
Score = 55.6 bits (128), Expect = 2e-06
Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENR 1532
E + PT+ LKN+T E + L C G P P VTWYR+ +++++ + T+++
Sbjct: 891 EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG 950
Query: 1533 -XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+ C A N+ G V TSC + +Q
Sbjct: 951 IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 987
Score = 53.6 bits (123), Expect = 7e-06
Identities = 27/100 (27%), Positives = 48/100 (48%), Gaps = 2/100 (2%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
T +++ P V P +G T +F C+V GYP+P++ W+ +I+ S+ F++ Y
Sbjct: 1787 TDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY- 1845
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
D + L I + D G A+N G +L ++
Sbjct: 1846 -DGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1884
Score = 53.6 bits (123), Expect = 7e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 12/151 (7%)
Query: 686 SDMHMYCSVLKITNVK-----KFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---PPQV 737
SD C+ +K+T + +E ++ V A N +G S P L + K+ PP
Sbjct: 15595 SDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKG-ISDPRQLSVPVIAKDLVIPPAF 15653
Query: 738 IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV 797
+ V GE + + +G P P +TW K+N P+K + T + ++L K
Sbjct: 15654 KLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDA 15713
Query: 798 --KDEGVYTLKAENSEGIA-ETSAVITVEEP 825
+D G Y +K NS G A ET VI +++P
Sbjct: 15714 CREDVGHYVVKLTNSAGEAIETLNVIVLDKP 15744
Score = 53.2 bits (122), Expect = 1e-05
Identities = 47/200 (23%), Positives = 84/200 (42%), Gaps = 15/200 (7%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTH 787
+++ P + PL + +G+ V L+ + + W NK V + D +T+
Sbjct: 4239 KEDGPMIHTPLVDTVSEEGDIVHLTTSITNAKE--VNWYFENKLVPSDEKFKCLQDQNTY 4296
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
++ I K +G Y +A N G TSA +TV + P+ + + + V
Sbjct: 4297 TLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVK-----RAAPVIKRKIEPLEVALG 4351
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSE--TITQNFDGENIELVITNVDSEIDSGDYK 905
K + P W++ I S+ +I + ++E++ T V +D G+Y
Sbjct: 4352 HLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQV---VDCGEYT 4408
Query: 906 CVASNSAGKSSHGARVTIDV 925
C ASN G S A +T+ V
Sbjct: 4409 CKASNEYGSVSCTATLTVTV 4428
Score = 52.8 bits (121), Expect = 1e-05
Identities = 35/169 (20%), Positives = 68/169 (40%), Gaps = 4/169 (2%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
AEN G++ + + E P +++T K +L ++ P+P I W
Sbjct: 24010 AENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKW 24069
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
YR + + S + DG L + + E D G Y C+A+N G+ +++ +
Sbjct: 24070 YRFGKELIQSRKYKMSSDGRTHTLTVMTEEQE-DEGVYTCIATNEVGEVETSSKLLLQAT 24128
Query: 927 KVTFVKH-LQKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDH 972
+ L++ Y G T+ L + W+H +K + ++
Sbjct: 24129 PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSEN 24177
Score = 52.0 bits (119), Expect = 2e-05
Identities = 36/131 (27%), Positives = 66/131 (50%), Gaps = 5/131 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLP-IVLKIKTGEK-EPP--QVIEPLKSMI-VRQGES 751
+ ++K Q+ ++ V AVN +G + + +I+ E+ E P ++ + LK + +R G S
Sbjct: 22907 VPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGAS 22966
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L V G P P ITW K + + +++S+ I+ D G YT++AEN
Sbjct: 22967 LRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQS 23026
Query: 812 GIAETSAVITV 822
G + ++ V
Sbjct: 23027 GKKSATVLVKV 23037
Score = 51.6 bits (118), Expect = 3e-05
Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 5/116 (4%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT--I 791
PP ++ LK++ V +GESV L + G P PT+TW + + +++ I +
Sbjct: 896 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 955
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
++ +D G +T A N G TS + V+ E E +F T +EK
Sbjct: 956 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKF---TTEEK 1008
Score = 51.6 bits (118), Expect = 3e-05
Identities = 35/117 (29%), Positives = 59/117 (50%), Gaps = 10/117 (8%)
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKSMI-VRQGESVILSAQV 758
+F+ T V ++ E S P+ + E PP++ +KS++ V+ G +V L A V
Sbjct: 12766 QFRAIARTAVNISPPSEPSDPVTI---LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 12822
Query: 759 VGNPRPTITWCKNN---KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
G P PT++W K+ KP + + + ++ + + KD G YT+ AENS G
Sbjct: 12823 FGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNR-KDSGDYTITAENSSG 12878
Score = 51.2 bits (117), Expect = 4e-05
Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 4/120 (3%)
Query: 486 KKLNEKIDKLPVFEK--PTSEEQ-SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQIT 542
KK ++K + V K P + E S P+ V L+ S +F + G PRP
Sbjct: 26328 KKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI 26387
Query: 543 WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
W + I +++ +D L I + D+G +TC KN+AG SS+ +L ++A
Sbjct: 26388 WTKDGKAITQGGKYKL-SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKA 26446
Score = 50.8 bits (116), Expect = 5e-05
Identities = 40/140 (28%), Positives = 71/140 (50%), Gaps = 14/140 (10%)
Query: 696 KITNVKKFQEGTYTVVAVNREGE---ASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQG 749
K+T ++ Q + V+AVN GE A +P + +K EPP++I + ++ G
Sbjct: 10678 KVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKD-RLEPPELILDANMAREQHIKVG 10736
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI---TILKPKKVKDEGVYTLK 806
+++ LSA + G P P +TW K ++ PTK+ D + ++ +D G+Y+L
Sbjct: 10737 DTLRLSAIIKGVPFPKVTWKKEDRDA---PTKARIDVTPVGSKLEIRNAAHEDGGIYSLT 10793
Query: 807 AENSEGIAETSA-VITVEEP 825
EN G S V+ +++P
Sbjct: 10794 VENPAGSKTVSVKVLVLDKP 10813
Score = 50.8 bits (116), Expect = 5e-05
Identities = 38/149 (25%), Positives = 69/149 (46%), Gaps = 8/149 (5%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLK--IKTGEKEPPQVIE--P--LKSMIVRQGE 750
+T + + ++A N G S P I T ++ P ++E P +I++ GE
Sbjct: 21418 VTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGE 21477
Query: 751 SVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSITILKPKKVKD-EGVYTLKAE 808
S+ + A V G P P +TW K+ + K + + S ++ +D GVYT++A+
Sbjct: 21478 SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAK 21537
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFIN 837
N+ G A+ + V++ + P F N
Sbjct: 21538 NASGSAKAEIKVKVQDTPGKVVGPIRFTN 21566
Score = 50.4 bits (115), Expect = 7e-05
Identities = 73/330 (22%), Positives = 129/330 (39%), Gaps = 42/330 (12%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E + F + K + EG + C++ P P IAW G+ I E + D
Sbjct: 1241 EAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGR 1300
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+ L+I V EG YT A N +G A I +G+ +EP +
Sbjct: 1301 ---ASLRIPVVLPEDEGIYTAFASNIKGNA-------ICSGKL----YVEPAAPL---GA 1343
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ I + + V R + P++ P + + P ++ + +
Sbjct: 1344 PTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR----------MSPARMSPARMSPARMSP 1393
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ ET +E E P+F+ + E T + +V P+P W+ +
Sbjct: 1394 GRRLEET------DESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHD 1447
Query: 870 NEIISPSET--ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID-VE 926
+ I T + DG +++ S DSG++ VA N AG+SS +T++ VE
Sbjct: 1448 GQQIVNDYTHKVVIKEDGTQSLIIVPATPS--DSGEWTVVAQNRAGRSSISVILTVEAVE 1505
Query: 927 ---KVTFVKHLQKSYETEEGKTVILECQTS 953
K FV+ L K+ +EG + ++ + +
Sbjct: 1506 HQVKPMFVEKL-KNVNIKEGSQLEMKVRAT 1534
Score = 50.4 bits (115), Expect = 7e-05
Identities = 51/230 (22%), Positives = 89/230 (38%), Gaps = 12/230 (5%)
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE----PPQVIEPLKSMIVRQ 748
+V + N+ + E + V N GE+ + + T + + P E L+++ VR
Sbjct: 24385 TVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRY 24444
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTK-----SDGDTHSITILKPKKVKDEGVY 803
+ L +V G+P+P + W + K + A K G H + I+ D VY
Sbjct: 24445 QSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL-IIASVTDDDATVY 24503
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
++A N G +A + VE P + + P + + + + + P P
Sbjct: 24504 QVRATNQGGSVSGTASLEVEVPAKIHL--PKTLEGMGAVHALRGEVVSIKIPFSGKPDPV 24561
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
ITW + ++I + LV N D+G Y A N G
Sbjct: 24562 ITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 24611
Score = 50.0 bits (114), Expect = 9e-05
Identities = 54/226 (23%), Positives = 96/226 (42%), Gaps = 22/226 (9%)
Query: 705 EGTYTVVAVNREGEA--SLP---IVLKIKTGEKEPPQVIEPLKSMIV-------RQGESV 752
E ++ + A+N+ G + S P + ++ P+VI+ KS + G S
Sbjct: 12664 EYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSK 12723
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
I+ V P W + N +P + ++ T L+ K A N
Sbjct: 12724 IIGYFVEACKLPGDKWVRCNTAPHQIPQEE----YTATGLEEKAQYQFRAIARTAVNISP 12779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQE--ITVKEKGTIKLVARVTRNPVPSITWYRNN 870
+E S +T+ EN P + ++ + +TVK + L A V P+P+++W ++
Sbjct: 12780 PSEPSDPVTI---LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDG 12836
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
++ P+E I L + +V+ + DSGDY A NS+G S
Sbjct: 12837 TLLKPAEGIKMAMQRNLCTLELFSVNRK-DSGDYTITAENSSGSKS 12881
Score = 49.6 bits (113), Expect = 1e-04
Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 3/118 (2%)
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+ E E +A A+ V +E +P + + + + V E T + RVT P P +
Sbjct: 1769 RIEELERMAHEGALTGVTTDQKEKQKPDIVLYP-EPVRVLEGETARFRCRVTGYPQPKVN 1827
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
WY N ++I S+ +DG + L I + S D+G+ K A N G H ++ I
Sbjct: 1828 WYLNGQLIRKSKRFRVRYDGIHY-LDIVDCKS-YDTGEVKVTAENPEGVIEHKVKLEI 1883
Score = 49.6 bits (113), Expect = 1e-04
Identities = 44/129 (34%), Positives = 62/129 (48%), Gaps = 13/129 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-----VRQGES 751
+ N+ + Q + V AVN GE+ + L + + E P I+ S+ V+ GE
Sbjct: 8859 VENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEP 8918
Query: 752 VILSAQVVGNPRPTITWCKN----NKPVKALP-TKSD-GDTHSITILK-PKKVK-DEGVY 803
V + A V G P P I W KN KP AL TK + + + T L PK V+ D+G Y
Sbjct: 8919 VHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTY 8978
Query: 804 TLKAENSEG 812
T+ A N G
Sbjct: 8979 TVTASNRLG 8987
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/127 (26%), Positives = 55/127 (43%), Gaps = 3/127 (2%)
Query: 477 ENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGY 536
E++ +Y+ + LN+ K K T +++ AP+ K+ P G +F C+++
Sbjct: 4306 EDHQGEYVCEALNDS-GKTATSAKLTVVKRA-APVIKRKIEPLEVALGHLAKFTCEIQSA 4363
Query: 537 PRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTT 596
P + WF+ I S D +++L I D G +TC A N G S T
Sbjct: 4364 PNVRFQWFKAGREIYES-DKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTA 4422
Query: 597 ELIVEAP 603
L V P
Sbjct: 4423 TLTVTVP 4429
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPP---LFINRFQEITVKEKGTIKLVARVTRN 859
+ +KAEN G+ I +E +E PP L + + + VK T++ A +
Sbjct: 10983 FRVKAENIVGLGLPDTTIPIE--CQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGV 11040
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
PVP+ W + I E T D + L I N D+G+Y+ SN+AG +
Sbjct: 11041 PVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRR-DTGEYQITVSNAAGSKTVAV 11099
Query: 920 RVTI 923
+T+
Sbjct: 11100 HLTV 11103
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/130 (26%), Positives = 66/130 (50%), Gaps = 11/130 (8%)
Query: 691 YCSVLKITNVKKFQEGTYTVVA---VNREGEASLPIVLKIKTGEKEPPQVIEPLKS---M 744
Y V ++T ++++ + A V+ E++ PI++K + EPP+V+ +K +
Sbjct: 19246 YFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVK---DDVEPPRVMMDVKFRDVI 19302
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPV--KALPTKSDGDTHSITILKPKKVKDEGV 802
+V+ GE + ++A + G P P I+W K+ + +A D H++ +K +D G
Sbjct: 19303 VVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQ 19362
Query: 803 YTLKAENSEG 812
Y L +N G
Sbjct: 19363 YVLTLKNVAG 19372
Score = 48.8 bits (111), Expect = 2e-04
Identities = 42/198 (21%), Positives = 80/198 (40%), Gaps = 14/198 (7%)
Query: 1472 KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY-- 1529
K+ +++P + + +++ T D G P P+ WY++G K++ + Y
Sbjct: 2022 KIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWY 2081
Query: 1530 ---ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE--DIKQKH 1584
+N A N GE + + +Q K +IT + E D+ K
Sbjct: 2082 WPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKE 2141
Query: 1585 KVGDEWLVTAVIEGIPP-PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY 1643
K + + T E P +V WYK+G ++ +Y + + K + I + S + Y
Sbjct: 2142 K---DTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDY 2198
Query: 1644 T---IEASNTAGTSSVEV 1658
+ +E N T+ + V
Sbjct: 2199 SCVLVEDENVKTTAKLIV 2216
Score = 48.0 bits (109), Expect = 4e-04
Identities = 76/333 (22%), Positives = 128/333 (38%), Gaps = 34/333 (10%)
Query: 1090 ILRDESCTAEVTVVELP--PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEI 1146
++ D S T E P P IT+ QK+ +G F ++ V W K G +
Sbjct: 1017 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1076
Query: 1147 QFSNHIQLTIDGK--KQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTL 1200
+++ + + + KL I DDAGEY+ V G + +A L +EE +
Sbjct: 1077 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL-LEEADYELLM 1135
Query: 1201 RLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
+ + +L A++ ET Y + + E+ + + K T+++R E
Sbjct: 1136 KSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE 1195
Query: 1261 DDQ-------------CEYTCV------LLDAKSTTKLKVEVVEFPPKIVDYE---REYR 1298
D + EY + LL+ K+ V++ E ++ + YR
Sbjct: 1196 DQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDLRIKNYR 1255
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC-KHTKPSIDSKSASLTIKKVENTDAGI 1357
I G VT +P P W + K IK ++ + ASL I V D GI
Sbjct: 1256 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1315
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
Y N G+A + ++ +P G P +
Sbjct: 1316 YTAFASNIKGNA-ICSGKLYVEPAAPLGAPTYI 1347
Score = 48.0 bits (109), Expect = 4e-04
Identities = 54/243 (22%), Positives = 85/243 (34%), Gaps = 21/243 (8%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVE--GYPRPQITWFRQTAIIKPSQDFQMYYD 561
+E+ P F +KL FEC++ G P + W ++ + +M +
Sbjct: 1651 KEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMI-N 1709
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV--EAPLSDHGS---------- 609
+ +L + D+G TC A N G ++ LIV E L +
Sbjct: 1710 EFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQR 1769
Query: 610 -EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWL 668
E D E P P+ V EG CR+ P+P + W
Sbjct: 1770 IEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWY 1829
Query: 669 FKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
G+ I + V + +H L I + K + G V A N EG + L+I+
Sbjct: 1830 LNGQLIRKSKRFRVRYDG-IH----YLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1884
Query: 729 TGE 731
E
Sbjct: 1885 QRE 1887
Score = 48.0 bits (109), Expect = 4e-04
Identities = 24/77 (31%), Positives = 44/77 (57%), Gaps = 1/77 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+ V + V G P P ++W + ++KP++ +M N+ TL + V +D+G +T
Sbjct: 12813 GTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQR-NLCTLELFSVNRKDSGDYTI 12871
Query: 584 VAKNAAGFASSTTELIV 600
A+N++G S+T +L V
Sbjct: 12872 TAENSSGSKSATIKLKV 12888
Score = 47.6 bits (108), Expect = 5e-04
Identities = 41/190 (21%), Positives = 72/190 (37%), Gaps = 7/190 (3%)
Query: 1478 KIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXX 1534
K P + PL + +E + + LT + V WY + K + + K +
Sbjct: 4239 KEDGPMIHTPLVDTVSEEGDIVHLTTSITNAKE--VNWYFENKLVPSDEKFKCLQDQNTY 4296
Query: 1535 XXXXXXXXXXXXX--YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLV 1592
Y C A ND G+ TS + + ++ I + + +G
Sbjct: 4297 TLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKF 4356
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
T I+ P W+K G ++ + +I + + S + I + +YT +ASN G
Sbjct: 4357 TCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYG 4416
Query: 1653 TSSVEVTLKV 1662
+ S TL V
Sbjct: 4417 SVSCTATLTV 4426
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/68 (35%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P PE W+ +G ++ ND + + KE T + I S S ++T+ A N AG S
Sbjct: 1434 VVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRS 1493
Query: 1655 SVEVTLKV 1662
S+ V L V
Sbjct: 1494 SISVILTV 1501
Score = 47.2 bits (107), Expect = 6e-04
Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 9/158 (5%)
Query: 1229 WYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK----LKVEV 1283
W+ + ++ D +I + ++LII T D E+T V + + L VE
Sbjct: 1444 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA 1503
Query: 1284 VEFP--PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
VE P V+ + IK GS + + V P P+ W+ NS II K+ K I+
Sbjct: 1504 VEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGT 1563
Query: 1342 --SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
A+L I + D+ Y N G V +
Sbjct: 1564 KGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1601
Score = 47.2 bits (107), Expect = 6e-04
Identities = 47/207 (22%), Positives = 87/207 (42%), Gaps = 17/207 (8%)
Query: 697 ITNVKKFQEGTYTVVAVNREGE---ASLPIVLKIKTGEKEPPQVIEPL--KSMIVRQGES 751
+T++ + E + V+A N G A +P +K+ + P ++ + + VRQG
Sbjct: 23597 LTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGV 23656
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L+ + G P P W K + + + +TH+ ++K D G Y L EN
Sbjct: 23657 IRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKC 23716
Query: 812 GIAETSAVITVEEPTEENA-EPPLFINRFQEITVK-------EKGTIKLVARV-TRNPVP 862
G + + I V N+ E PL + Q +V+ + G ++ + R VP
Sbjct: 23717 G--KKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVP 23774
Query: 863 SITWYRNNEIISPSETITQNFDGENIE 889
WY + + + + + EN+E
Sbjct: 23775 KAAWYTIDSRVRGTSLVVKGLK-ENVE 23800
Score = 46.8 bits (106), Expect = 9e-04
Identities = 39/124 (31%), Positives = 57/124 (45%), Gaps = 6/124 (4%)
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQGESVILSAQVVG 760
+E V AVN G S P + K+P P + +IV +GE + +
Sbjct: 7857 KEYVLRVRAVNAIG-VSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRA 7915
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVK-DEGVYTLKAENSEGIAETSA 818
P PT++W K+ K VKA + + H S + PK V+ D G+YT+ EN G A S
Sbjct: 7916 VPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASI 7975
Query: 819 VITV 822
+ V
Sbjct: 7976 NVKV 7979
Score = 46.4 bits (105), Expect = 0.001
Identities = 39/149 (26%), Positives = 67/149 (44%), Gaps = 4/149 (2%)
Query: 803 YTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
+ +KA N EG A + + E L + ITV+ TI+++ARV P
Sbjct: 11380 FRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRP 11439
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
P ITW + +++ + + D +EL I D G Y A NS+G + A
Sbjct: 11440 EPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEA-VRADHGKYIISAKNSSGHAQGSAI 11498
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILE 949
V + +++ ++L+ + T+E T+ E
Sbjct: 11499 VNV-LDRPGPCQNLKVTNVTKENCTISWE 11526
Score = 46.4 bits (105), Expect = 0.001
Identities = 31/122 (25%), Positives = 59/122 (48%), Gaps = 5/122 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ + A N+ G++ V E E+ P + + ++IT+K +++ A V P P
Sbjct: 12374 FRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMP--EQITIKAGKKLRIEAHVYGKPHP 12431
Query: 863 SITWYR-NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
+ W + +E+++ S D +I L+I +V + DSG Y A NS+G + +V
Sbjct: 12432 TCKWKKGEDEVVTSSHLAVHKADSSSI-LIIKDVTRK-DSGYYSLTAENSSGTDTQKIKV 12489
Query: 922 TI 923
+
Sbjct: 12490 VV 12491
Score = 46.4 bits (105), Expect = 0.001
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 5/116 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFI--NRFQEITVKEKGTIKLVARVTRNP 860
+ + A N +G++E S I EP E P L + + + +T++ +++L+ V+ P
Sbjct: 22918 FRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRP 22977
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P ITW + ++ I E+ L+I + + D+G Y A N +GK S
Sbjct: 22978 PPVITWSKQGIDLASRAIIDTT---ESYSLLIVDKVNRYDAGKYTIEAENQSGKKS 23030
Score = 46.0 bits (104), Expect = 0.001
Identities = 28/121 (23%), Positives = 52/121 (42%)
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
KF+ + + GE + I +K + + ++V G + + A V G
Sbjct: 9995 KFRVSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGK 10054
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
P PT+TW N + + T S ++K + +GVY+L A+N G + + ++
Sbjct: 10055 PPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVD 10114
Query: 822 V 822
V
Sbjct: 10115 V 10115
Score = 46.0 bits (104), Expect = 0.001
Identities = 27/79 (34%), Positives = 42/79 (53%), Gaps = 2/79 (2%)
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKP-VKALPTKSDGDTHSITILKPKKVK-DEGVY 803
VR G+++ + A+V G P P ITW K K V+ D + + + V+ D G Y
Sbjct: 11423 VRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKY 11482
Query: 804 TLKAENSEGIAETSAVITV 822
+ A+NS G A+ SA++ V
Sbjct: 11483 IISAKNSSGHAQGSAIVNV 11501
Score = 45.6 bits (103), Expect = 0.002
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G+ + I G P P V WY+ ++E+ ++ IT + + + I+E S ++T
Sbjct: 911 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 970
Query: 1647 ASNTAGTSSVEVTLKV 1662
A N AGT S L V
Sbjct: 971 AVNEAGTVSTSCYLAV 986
Score = 45.6 bits (103), Expect = 0.002
Identities = 40/182 (21%), Positives = 76/182 (41%), Gaps = 6/182 (3%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTH 787
EK+ P ++ + + V +GE+ +V G P+P + W N + + K + DG H
Sbjct: 1791 EKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IH 1849
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
+ I+ K D G + AEN EG+ E + +++ + + E V E
Sbjct: 1850 YLDIVDCKSY-DTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEP 1908
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCV 907
G ++ + PV + T + + +E IT E E + + + G Y+ +
Sbjct: 1909 GKLQFEVQKVDRPVDT-TETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 1967
Query: 908 AS 909
+
Sbjct: 1968 TA 1969
Score = 45.2 bits (102), Expect = 0.003
Identities = 41/179 (22%), Positives = 80/179 (44%), Gaps = 14/179 (7%)
Query: 747 RQGESVILSAQVVGNPRPTITWCK-NNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+ G S I+ V P T W + N++P+K L K + + P K E V +
Sbjct: 7813 KNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEG------VVPDK---EYVLRV 7863
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVK-EKGTIKLVARVTRNPVPSI 864
+A N+ G++E S + + + +P + + I ++ EK +I + R PVP++
Sbjct: 7864 RAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAV--PVPTV 7921
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+W+++ + + S+ +T D + L + D+G Y N G ++ V +
Sbjct: 7922 SWHKDGKEVKASDRLTMKNDHISAHLEVPK-SVRADAGIYTITLENKLGSATASINVKV 7979
Score = 45.2 bits (102), Expect = 0.003
Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G+++ L+ + P P ++W G + P E I +A++ ++ C+ L++ +V +
Sbjct: 12810 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL---CT-LELFSVNRKD 12865
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV 737
G YT+ A N G S I LK+ P V
Sbjct: 12866 SGDYTITAENSSGSKSATIKLKVLDKPGPPASV 12898
Score = 45.2 bits (102), Expect = 0.003
Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 9/99 (9%)
Query: 731 EKEPPQV-IEPL--KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDG 784
E +PP++ ++P +++V GES + A + G P PTI W K ++ + L KS
Sbjct: 16040 EVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTD 16099
Query: 785 DTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
S+++ +V D G Y LKA+N G E S + V+
Sbjct: 16100 FATSLSVKDAVRV-DSGNYILKAKNVAG--ERSVTVNVK 16135
Score = 45.2 bits (102), Expect = 0.003
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 1/81 (1%)
Query: 520 HTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAG 579
H P G V+ + G P P +WF + ++ S+ + VA L IRE D G
Sbjct: 23252 HVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVE-THTKVAKLTIRETTIRDTG 23310
Query: 580 TFTCVAKNAAGFASSTTELIV 600
+T KN G S T ++I+
Sbjct: 23311 EYTLELKNVTGTTSETIKVII 23331
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/125 (24%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
+E + + A+N +GI++ ++V ++ PP F F TV +K+
Sbjct: 15618 EEYSFRVSAQNEKGISDPRQ-LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIG 15676
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P++TW+++N + + + N L I + E D G Y +NSAG++
Sbjct: 15677 RPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACRE-DVGHYVVKLTNSAGEAIET 15735
Query: 919 ARVTI 923
V +
Sbjct: 15736 LNVIV 15740
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 13/136 (9%)
Query: 697 ITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIE---PLKSMIVRQ 748
++ +++ E + V A N+ G E LP+++K + EPP++ P ++ VR
Sbjct: 19937 VSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIK---EQLEPPEIDMKNFPSHTVYVRA 19993
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKA-LPTKSDGDTHSITI-LKPKKVKDEGVYTLK 806
G ++ + + G P P +T ++ P+KA + ++ ++TI LK D G Y +
Sbjct: 19994 GSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEIT 20053
Query: 807 AENSEGIAETSAVITV 822
A NS G + I V
Sbjct: 20054 AANSSGTTKAFINIVV 20069
Score = 44.8 bits (101), Expect = 0.003
Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 9/131 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK---EPPQV---IEPLKSMIVRQGE 750
++N+K + V AVN G+ PI + K E P++ + S+I + GE
Sbjct: 20732 VSNLKPGVNYYFRVSAVNCAGQGE-PIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGE 20790
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAE 808
V + G P PT+TW K+ K + + S +T S ++L +V D G Y L E
Sbjct: 20791 DVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIE 20850
Query: 809 NSEGIAETSAV 819
N G ++S V
Sbjct: 20851 NGVGEPKSSTV 20861
Score = 44.4 bits (100), Expect = 0.005
Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F + L + +G+T EC+V ++ WF+ I S+ +++ D V LVI
Sbjct: 5790 FTKPLEDQTVEEGATAVLECEVSR-ENAKVKWFKNGTEILKSKKYEIVADG-RVRKLVIH 5847
Query: 572 EVFPEDAGTFTCVAKN 587
+ PED T+TC AK+
Sbjct: 5848 DCTPEDIKTYTCDAKD 5863
Score = 44.4 bits (100), Expect = 0.005
Identities = 32/114 (28%), Positives = 48/114 (42%), Gaps = 5/114 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRF--QEITVKEKGTIKLVARVTRNP 860
+ + A N GI E V V E + P L ++ I V G I+++A V+ P
Sbjct: 9996 FRVSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKP 10055
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
P++TW N + TI + +VI N G Y +A N AG+
Sbjct: 10056 PPTVTWNMNERTLPQEATIETT--AISSSMVIKNCQRS-HQGVYSLLAKNEAGE 10106
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/90 (25%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTI 1156
A V + PP +++ L+N V +G T E ++ + V W+++ +I+ S Q+T
Sbjct: 888 APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCT 1186
+L I + +D+G ++C N T
Sbjct: 948 QSGIARLMIREAFAEDSGRFTCSAVNEAGT 977
Score = 44.0 bits (99), Expect = 0.006
Identities = 38/133 (28%), Positives = 61/133 (45%), Gaps = 7/133 (5%)
Query: 795 KKVKDEGVYTLK--AENS--EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
K++++ Y L+ A N+ EG + +TV EP E A L ++ I + T+
Sbjct: 8567 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVE-LDVSVKGGIQIMAGKTL 8625
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
++ A VT PVP+ W + + + N G EL+I + + D G Y A+N
Sbjct: 8626 RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNV-GTKSELIIKDALRK-DHGRYVITATN 8683
Query: 911 SAGKSSHGARVTI 923
S G ARV +
Sbjct: 8684 SCGSKFAAARVEV 8696
Score = 44.0 bits (99), Expect = 0.006
Identities = 38/148 (25%), Positives = 62/148 (41%), Gaps = 10/148 (6%)
Query: 779 PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPP---LF 835
PT G ++T LK E + + A NSEG+ E A + +E EPP L
Sbjct: 18558 PTGLQGKQFTVTKLKENT---EYNFRICAINSEGVGEP-ATLPGSVVAQERIEPPEIELD 18613
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV 895
+ + + ++ T++L + P P + W + I++ I LVI NV
Sbjct: 18614 ADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQI--EVTSSFTMLVIDNV 18671
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ DSG Y N++G + V +
Sbjct: 18672 -TRFDSGRYNLTLENNSGSKTAFVNVRV 18698
Score = 43.6 bits (98), Expect = 0.008
Identities = 44/191 (23%), Positives = 80/191 (41%), Gaps = 12/191 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PP+ K + V+EG+++ + ++ +P P + W FK PD V ++ ++
Sbjct: 9619 MPPSIDLKEFME-VEEGTNVNIVAKIKGVPFPTLTW-FKAPPKKPDNKEPVLYDTHVNKL 9676
Query: 692 C----SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
L I ++ G YT+ AVN G AS + L + G PP + P+K V
Sbjct: 9677 VVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV-LGRPGPP--VGPIKFESVS 9733
Query: 748 QGESVI--LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK-DEGVYT 804
+ + + G + T + + + + T PK ++ E V+
Sbjct: 9734 ADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFR 9793
Query: 805 LKAENSEGIAE 815
+ A+N GI E
Sbjct: 9794 IMAQNKYGIGE 9804
Score = 43.6 bits (98), Expect = 0.008
Identities = 42/153 (27%), Positives = 68/153 (44%), Gaps = 14/153 (9%)
Query: 700 VKKFQEGT---YTVVAVNREGEASLPIVLKIKTGEKE--PPQV-IEPLKSMIVRQGESVI 753
VK +EG Y V AVN G+ K T + E PP + ++ + +R GE+
Sbjct: 10281 VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFA 10340
Query: 754 LSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
L+ + G P+P ++W K+ V K+ T ++ +K K+ D G Y + ENS
Sbjct: 10341 LTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKR-SDSGKYCVVVENS 10399
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G + + V + PP+ F E+T
Sbjct: 10400 TGSRKGFCQVNV----VDRPGPPVGPVSFDEVT 10428
Score = 43.2 bits (97), Expect = 0.010
Identities = 105/491 (21%), Positives = 175/491 (35%), Gaps = 42/491 (8%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEI--QFSNHIQLTIDGKKQK 1162
P + + + K +G A F++++ G + WF DG +I +++ + + DG Q
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVV-GRPMPETFWFHDGQQIVNDYTHKVVIKEDGT-QS 1468
Query: 1163 LKIYDCDLDDAGEYSC----EVGNSKCTAILTVE--EPSIN--FTLRLPEFILVPANTDA 1214
L I D+GE++ G S + ILTVE E + F +L + +
Sbjct: 1469 LIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSQLE 1528
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTE--KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
+ D+ W K +I + K + + L I D YT ++
Sbjct: 1529 MKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAIN 1588
Query: 1273 --AKSTTKLKVEV-VEFPP-----KIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
+ TT+ KV V VEF K++ YR K + L + + Q ++W
Sbjct: 1589 KAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQ--EQW-EE 1645
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+ K K KP K SL +++ ++ RL D M V L P
Sbjct: 1646 GDLYDKEKQQKPFFKKKLTSL---RLKRFGPAHFECRLTPI---GDPTMVVEWLHDGKPL 1699
Query: 1385 GKPNILEI--DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
N L + + ++ + + + I D T S I K + S+
Sbjct: 1700 EAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHT---SATLIVKDEKSLVE 1756
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
R + E++ A E + + Q P + + + E
Sbjct: 1757 ESQLPEGRKGLQRIEELERM-AHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFR 1815
Query: 1503 CIFGGVPQPKVTWYRDG---KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
C G PQPKV WY +G +K K + Y+ K A N G +
Sbjct: 1816 CRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVI 1875
Query: 1560 ETSCVVGIQQK 1570
E + IQQ+
Sbjct: 1876 EHKVKLEIQQR 1886
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/134 (29%), Positives = 66/134 (49%), Gaps = 12/134 (8%)
Query: 475 MDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSM----AP-IFVE-KLRPKHTPD-GSTV 527
++E + Y K LN + P +PT E Q++ AP IF++ KL T G+ +
Sbjct: 7154 LEEGKWYAYRVKALNRQGASKP--SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKI 7211
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATLVIREVFPEDAGTFTCVAK 586
+ V G P P+ITW + I+K QD ++ ++ +T+ I + D GT+ A
Sbjct: 7212 ELPATVTGKPEPKITWTKADMILK--QDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAV 7269
Query: 587 NAAGFASSTTELIV 600
N G A++ E+ V
Sbjct: 7270 NVCGRATAVVEVNV 7283
Score = 43.2 bits (97), Expect = 0.010
Identities = 30/119 (25%), Positives = 58/119 (48%), Gaps = 7/119 (5%)
Query: 709 TVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL--KSMIVRQGESVILSA-QVVGNPRPT 765
T A++ E++ I+ K + + P V++P + ++ G++++L+A ++G P P
Sbjct: 13856 TAGAISAPSESTETIICKDEY--EAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPK 13913
Query: 766 ITWCKNNKPVKA--LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+W K K ++ + + T S+ +K KD G YT+ A N G +TV
Sbjct: 13914 SSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTV 13972
Score = 43.2 bits (97), Expect = 0.010
Identities = 32/106 (30%), Positives = 55/106 (51%), Gaps = 8/106 (7%)
Query: 712 AVNREGEASLPIVLKIKTGEKEPPQV-IEPL--KSMIVRQGESVILSAQVVGNPRPTITW 768
A+++ +++ PI K E E P++ ++P +++V GE+ L A V G P PTI W
Sbjct: 17106 AISKPSDSTGPITAK---DEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEW 17162
Query: 769 CKNNKPVK--ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ +K ++ A + D ++ I+K D G Y L+A N G
Sbjct: 17163 LRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAG 17208
Score = 43.2 bits (97), Expect = 0.010
Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 499 EKPTSEE--QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDF 556
EK T+ + ++A + K R +G + +F C +G P P +TW R+ ++ S
Sbjct: 26051 EKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARH 26110
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
Q+ +T I V D G ++ V +N+ G + L ++
Sbjct: 26111 QV-TTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ 26154
Score = 43.2 bits (97), Expect = 0.010
Identities = 18/66 (27%), Positives = 29/66 (43%)
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
+G P P V W + G L + +TT + S I ++ S Y++ N+ G
Sbjct: 26088 DGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEA 26147
Query: 1657 EVTLKV 1662
E TL +
Sbjct: 26148 EFTLTI 26153
Score = 42.7 bits (96), Expect = 0.014
Identities = 31/129 (24%), Positives = 61/129 (47%), Gaps = 12/129 (9%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPV 861
+ +KA N+ G+++ SA + + + P + + F E+ E+GT + +VA++ P
Sbjct: 9592 FRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEV---EEGTNVNIVAKIKGVPF 9648
Query: 862 PSITWYR-------NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
P++TW++ N E + + + + LVI D+G Y A N+ G
Sbjct: 9649 PTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQ-SRRSDTGLYTITAVNNLGT 9707
Query: 915 SSHGARVTI 923
+S R+ +
Sbjct: 9708 ASKEMRLNV 9716
Score = 42.7 bits (96), Expect = 0.014
Identities = 25/120 (20%), Positives = 57/120 (47%), Gaps = 4/120 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE-PPQV---IEPLKSMIVRQGESV 752
+ +++ ++ + + A+N G ++ ++ E+E P E ++++VR G S+
Sbjct: 14238 VPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSI 14297
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ + G P P +TW K+N +K + ++ ++ I+ D G + + EN G
Sbjct: 14298 RIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAG 14357
Score = 42.7 bits (96), Expect = 0.014
Identities = 25/75 (33%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTKSDGDTHSITILKPKKVKDE 800
++I++ GE+ L A V G P PT+ W K+ K ++ A D + + K +D
Sbjct: 14973 TVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDS 15032
Query: 801 GVYTLKAENSEGIAE 815
G YTL A N G A+
Sbjct: 15033 GAYTLTATNPGGFAK 15047
Score = 42.7 bits (96), Expect = 0.014
Identities = 37/154 (24%), Positives = 68/154 (44%), Gaps = 10/154 (6%)
Query: 695 LKITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+++ + + E + + A+N+ G + PI+++ K + +E K + +R G
Sbjct: 16401 IEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAG 16460
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ L + G P P + W K + ++ + + +L D G YTL EN
Sbjct: 16461 GSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLEN 16520
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
S G SA +TV + PP+ + + EIT
Sbjct: 16521 SSG--TKSAFVTVR--VLDTPSPPVNL-KVTEIT 16549
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/135 (24%), Positives = 60/135 (44%), Gaps = 7/135 (5%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---PPQVIEPLKSMIVRQGESVI 753
I+ + +E + V AVN +G + P L + ++ P V P + V+ E +
Sbjct: 18858 ISGLTAGEEYVFRVAAVNEKGRSD-PRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLK 18916
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAENSE 811
+ G P+ T+ W K+ + +K + + ++T L K+ +D G Y L NS
Sbjct: 18917 IDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSA 18976
Query: 812 G-IAETSAVITVEEP 825
G I +I ++ P
Sbjct: 18977 GSITVPITIIVLDRP 18991
Score = 42.7 bits (96), Expect = 0.014
Identities = 21/78 (26%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G +++ + V+G P P++TWF+ I+ + ++ D +L +R+ + G +T
Sbjct: 21476 GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEI-TDVLGSTSLFVRDATRDHRGVYTV 21534
Query: 584 VAKNAAGFASSTTELIVE 601
AKNA+G A + ++ V+
Sbjct: 21535 EAKNASGSAKAEIKVKVQ 21552
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISD 1247
+T + P+ FT L +++ +T + +V+W++ VI T IS
Sbjct: 1 MTTQAPT--FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF 58
Query: 1248 VKKRT-LIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
R L I T+ + Y+ + A ST +L V+ PP V + +++G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
S V L V P P ++ + I+ + S + SL I + D+G Y +
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
N+ G A + + + P K + ++ I+
Sbjct: 179 TNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQIS 214
Score = 41.9 bits (94), Expect = 0.024
Identities = 26/100 (26%), Positives = 40/100 (40%), Gaps = 4/100 (4%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PPT K V EG + LEC + P P + W + +I + + +S +
Sbjct: 896 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGI---- 951
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
+ L I G +T AVN G S L ++ E+
Sbjct: 952 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEE 991
Score = 41.9 bits (94), Expect = 0.024
Identities = 39/131 (29%), Positives = 56/131 (42%), Gaps = 8/131 (6%)
Query: 700 VKKFQEGT---YTVVAVNREGEASLPIVLKIKTGEKEPPQVIE---PLKSMI-VRQGESV 752
VK+ +EG V AVN GE + E + P +E +K I + G+++
Sbjct: 8566 VKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTL 8625
Query: 753 ILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ A V G P PT W K + K + T S I+K KD G Y + A NS
Sbjct: 8626 RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSC 8685
Query: 812 GIAETSAVITV 822
G +A + V
Sbjct: 8686 GSKFAAARVEV 8696
Score = 41.9 bits (94), Expect = 0.024
Identities = 39/133 (29%), Positives = 59/133 (44%), Gaps = 7/133 (5%)
Query: 696 KITNVKKFQEGTYTVVAVNREG--EA-SLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGE 750
+I+ + + QE V A+N+ G EA S+P +K + + P + E K ++VR G
Sbjct: 17484 EISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAGG 17543
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
S + G P P ITW + G ++ + D G Y LK ENS
Sbjct: 17544 SARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS 17603
Query: 811 EGIAETSAVITVE 823
G SA +TV+
Sbjct: 17604 SG--SKSAFVTVK 17614
Score = 41.9 bits (94), Expect = 0.024
Identities = 50/230 (21%), Positives = 94/230 (40%), Gaps = 10/230 (4%)
Query: 702 KFQEGTYTVVA--VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI--VRQGESVILSAQ 757
++Q TY + A V++ EAS PI+ + P+V + +S + + + ++
Sbjct: 22413 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 22472
Query: 758 VVGN--PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN--SEGI 813
VVG R ++ + + +K T + ++T L + V A S+G
Sbjct: 22473 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 22532
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
T V +E AE ++ +T++ + L A V P P I W + ++ +
Sbjct: 22533 ESTGPVTCRDEYAPPKAELDARLHG-DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL 22591
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E ++ + G+ VI D DSG Y N++G + V +
Sbjct: 22592 DLCEKVSLQYTGKRATAVIKFCDRS-DSGKYTLTVKNASGTKAVSVMVKV 22640
Score = 41.9 bits (94), Expect = 0.024
Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 5/123 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN-RFQE-ITVKEKGTIKLVARVTRNP 860
+ + A N+ G E + V + TE P ++ R+QE I V++ G I+L + P
Sbjct: 23608 FRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKP 23667
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
P W + + IS I + + ELVI D DSG Y V N GK + +
Sbjct: 23668 FPICKWTKEGQDISKRAMIATS--ETHTELVIKEADRG-DSGTYDLVLENKCGKKAVYIK 23724
Query: 921 VTI 923
V +
Sbjct: 23725 VRV 23727
Score = 41.5 bits (93), Expect = 0.032
Identities = 39/159 (24%), Positives = 63/159 (39%), Gaps = 11/159 (6%)
Query: 450 TSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEK-IDKLPVFEKPTSEEQSM 508
T + W K EE + + L++ Y ++ K +N + K P ++
Sbjct: 9561 TKKEAWRQCNKRDVEELQFT-VEDLVEGGEY-EFRVKAVNAAGVSKPSATVGPCDCQRPD 9618
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD------ 562
P ++ +G+ V +++G P P +TWF+ KP + YD
Sbjct: 9619 MPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPP-KKPDNKEPVLYDTHVNKLV 9677
Query: 563 -DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
D+ TLVI + D G +T A N G AS L V
Sbjct: 9678 VDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9716
Score = 41.5 bits (93), Expect = 0.032
Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--D 799
K++I+R G ++ L V G P P ITW K N ++ T T L+ + V D
Sbjct: 13204 KTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYD 13263
Query: 800 EGVYTLKAENSEGIAETSAVITV 822
G Y L ENS G E + V+ V
Sbjct: 13264 AGKYILTLENSCGKKEYTIVVKV 13286
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/139 (20%), Positives = 61/139 (43%), Gaps = 6/139 (4%)
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
H++T L ++ ++ ++A+N +G++E +T + P + ++ + T+
Sbjct: 23197 HTVTSLNEG---EQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHV 23253
Query: 847 KG--TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDY 904
++LV + P P+ +W+ + SE +T + +L I D+G+Y
Sbjct: 23254 PAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIR-DTGEY 23312
Query: 905 KCVASNSAGKSSHGARVTI 923
N G +S +V I
Sbjct: 23313 TLELKNVTGTTSETIKVII 23331
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/75 (29%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ ++AEN+ GI+E S + + P + + E VK I L A ++ +P P
Sbjct: 8155 FRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLE--VKRGDEIALDASISGSPYP 8212
Query: 863 SITWYRNNEIISPSE 877
+ITW ++ +I P E
Sbjct: 8213 TITWIKDENVIVPEE 8227
Score = 41.1 bits (92), Expect = 0.042
Identities = 33/131 (25%), Positives = 57/131 (43%), Gaps = 5/131 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEK--EPPQVIEP--LKSMIVRQGES 751
+T+++ +E + V A+N G+ S + IK ++ P I+ ++ +VR G S
Sbjct: 21818 VTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGAS 21877
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L G P PT W K + + D+ S ++ D G YTL EN+
Sbjct: 21878 IRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNS 21937
Query: 812 GIAETSAVITV 822
G + + V
Sbjct: 21938 GSKSITFTVKV 21948
Score = 40.7 bits (91), Expect = 0.056
Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 4/91 (4%)
Query: 1575 ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKE 1634
+SN DI +GD ++ + GIP P++ W+ NG L +Y + I
Sbjct: 3463 VSNADIS----MGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILF 3518
Query: 1635 LKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
K +YT ASN G + LK+ K
Sbjct: 3519 TKLEDEGEYTCMASNDYGKTICSAYLKINSK 3549
Score = 40.7 bits (91), Expect = 0.056
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T++ +V+G P P ITW ++ ++ + + D V L I+E D G +
Sbjct: 11426 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRV-ELQIKEAVRADHGKYII 11484
Query: 584 VAKNAAGFASST 595
AKN++G A +
Sbjct: 11485 SAKNSSGHAQGS 11496
Score = 40.7 bits (91), Expect = 0.056
Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 3/78 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV-IREVFPEDAGTFT 582
G ++ E V G PRP I+W + +K Q ++ ++ +T++ I+E +D G +T
Sbjct: 17829 GEDLKIEIPVIGRPRPNISWVKDGEPLK--QTTRVNVEETATSTVLHIKEGNKDDFGKYT 17886
Query: 583 CVAKNAAGFASSTTELIV 600
A N+AG A+ +IV
Sbjct: 17887 VTATNSAGTATENLSVIV 17904
Score = 40.7 bits (91), Expect = 0.056
Identities = 33/125 (26%), Positives = 57/125 (45%), Gaps = 9/125 (7%)
Query: 705 EGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQ 757
E + V +VN+ G ++S P + K + E+EP I E K++IV+ G S ++
Sbjct: 19655 EYVFRVKSVNKVGASDPSDSSDPQIAKER--EEEPLFDIDSEMRKTLIVKAGASFTMTVP 19712
Query: 758 VVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETS 817
G P P + W K + ++ D+ + ++ D G YTL +N A +
Sbjct: 19713 FRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLT 19772
Query: 818 AVITV 822
V+ V
Sbjct: 19773 LVVKV 19777
Score = 40.7 bits (91), Expect = 0.056
Identities = 40/142 (28%), Positives = 66/142 (46%), Gaps = 11/142 (7%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASL----PIVLK--IKTGEKEPPQVIEPLKSMIVRQ 748
++++ +K+ + V A N +G + PI +K I T E + + P + VR
Sbjct: 21023 IEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDI--PGAQVTVRI 21080
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDE--GVYTLK 806
G +V L G P+P+I+W K+ P+K T + L K K E G YT+
Sbjct: 21081 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 21140
Query: 807 AENSE-GIAETSAVITVEEPTE 827
+N+ IA VIT+ P++
Sbjct: 21141 LDNAVCRIAVPITVITLGPPSK 21162
Score = 40.3 bits (90), Expect = 0.074
Identities = 31/127 (24%), Positives = 58/127 (45%), Gaps = 6/127 (4%)
Query: 802 VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-TVKEKGTIKLVARVTRNP 860
+Y + + E+ V T E +E+ + P+ + + TVK TI+L A V P
Sbjct: 11673 IYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKP 11732
Query: 861 VPSITWYRNNEI--ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P + W ++ + ++ S + + ++ + +T D G Y A+N+AG S
Sbjct: 11733 FPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKA-KRSDGGKYVVTATNTAG--SFV 11789
Query: 919 ARVTIDV 925
A T++V
Sbjct: 11790 AYATVNV 11796
Score = 40.3 bits (90), Expect = 0.074
Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ E + G P+P ITW + +K + + D ++ TL I+E +D G +
Sbjct: 16747 GQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINV-TDSLDLTTLSIKETHKDDGGQYGI 16805
Query: 584 VAKNAAGFASSTTELI 599
N G +++ E++
Sbjct: 16806 TVANVVGQKTASIEIV 16821
Score = 40.3 bits (90), Expect = 0.074
Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATLVIREVFPEDAGTF 581
+G + C G P P++TW I + + + ++ D++ TL+I +V +D G +
Sbjct: 26845 EGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLY 26904
Query: 582 TCVAKNAAGFASSTTELIVEA 602
T N G S+T + + +
Sbjct: 26905 TLSLGNEFGSDSATVNIHIRS 26925
Score = 39.9 bits (89), Expect = 0.098
Identities = 28/106 (26%), Positives = 46/106 (43%), Gaps = 6/106 (5%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
I P+ + G D+ +E ++ P P+I+W+ GE + ++V +
Sbjct: 17813 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNV----EETAT 17868
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA--SLPIVLKIKTGEKEPP 735
+VL I K G YTV A N G A +L +++ K G P
Sbjct: 17869 STVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGP 17914
Score = 39.9 bits (89), Expect = 0.098
Identities = 28/79 (35%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTKSDGDTHSITILKPKKVKDEGVYT 804
R G SV L A + G P PTI W K++K ++ AL + + ++K + G Y
Sbjct: 20388 RAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYE 20447
Query: 805 LKAENSEGIAETSAVITVE 823
LK N+ G A SA I V+
Sbjct: 20448 LKLRNAMGSA--SATIRVQ 20464
Score = 39.5 bits (88), Expect = 0.13
Identities = 33/134 (24%), Positives = 65/134 (48%), Gaps = 14/134 (10%)
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV----- 1658
V+W+KN KL + I+++ KT + +KE+ S+ + + T+ ++V
Sbjct: 5107 VVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADP 5166
Query: 1659 --TLKVYDKPSKPEGPVIMR-EISRESVTIEWKPPLDDGG--LELTKYAIEKHEPDNNRW 1713
T+K++DK + + + ++ E+S++ V ++W DG + KY+I+
Sbjct: 5167 YFTVKLHDKTAVEKDEITLKCEVSKD-VPVKW---FKDGEEIVPSPKYSIKADGLRRILK 5222
Query: 1714 IKVADVDRDVETYC 1727
IK AD+ E C
Sbjct: 5223 IKKADLKDKGEYVC 5236
Score = 39.5 bits (88), Expect = 0.13
Identities = 26/100 (26%), Positives = 46/100 (46%), Gaps = 4/100 (4%)
Query: 504 EEQSMAPIFVEKLRPKHTP---DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
+EQ P K P HT GS ++ + + G P P++T R +K + F
Sbjct: 19971 KEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEI 20030
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+N+ T+ ++E DAG + A N++G + ++V
Sbjct: 20031 TAENL-TINLKESVTADAGRYEITAANSSGTTKAFINIVV 20069
Score = 39.5 bits (88), Expect = 0.13
Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G V E +G P+P I+W + +K S +F + +N TL I+ E G +T
Sbjct: 21081 GHNVHLELPYKGKPKPSISWLKDGLPLKES-EFVRFSKTENKITLSIKNAKKEHGGKYTV 21139
Query: 584 VAKNA 588
+ NA
Sbjct: 21140 ILDNA 21144
Score = 39.1 bits (87), Expect = 0.17
Identities = 34/142 (23%), Positives = 63/142 (44%), Gaps = 9/142 (6%)
Query: 808 ENSEGIAETSAVITVEEPTEENAEP-----PLFINRFQEITVKEKGTIKLVARVTRNPVP 862
E + V+T TEE A P P FI + + E G++ +V NP P
Sbjct: 1006 EEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKP 1065
Query: 863 SITWYRNNEIISPS--ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ W ++ ++ ++ N +LVI+ ++ D+G+Y V N G++S A
Sbjct: 1066 HVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFAD-DAGEYTIVVRNKHGETSASAS 1124
Query: 921 VTIDVEKVTFVKHLQKS-YETE 941
+ + + +K Q+ Y+T+
Sbjct: 1125 LLEEADYELLMKSQQEMLYQTQ 1146
Score = 39.1 bits (87), Expect = 0.17
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNIT-TKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P++ WYK+G ++++ + Y + ++ + +RI + YT ASN G +
Sbjct: 1268 MSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNA 1327
Query: 1655 SVEVTLKVYDKPSKPEG 1671
+ K+Y +P+ P G
Sbjct: 1328 I--CSGKLYVEPAAPLG 1342
Score = 39.1 bits (87), Expect = 0.17
Identities = 39/123 (31%), Positives = 55/123 (44%), Gaps = 8/123 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLK--IKTGE-KEPPQV---IEPLKSMIVRQGE 750
+T++ + QE + V A N+ G P LK IK E EPP++ K +IVR G
Sbjct: 12067 VTSLDENQEYEFRVCAQNQVG-IGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGC 12125
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSD-GDTHSITILKPKKVKDEGVYTLKAEN 809
+ L A V G P P +TW K + D DT + ++ D G Y+L N
Sbjct: 12126 PIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVN 12185
Query: 810 SEG 812
G
Sbjct: 12186 PAG 12188
Score = 39.1 bits (87), Expect = 0.17
Identities = 22/86 (25%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 839 FQEITVKEKGT-IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDS 897
+ E+ GT +KL A ++ P P+I WY++++ + + + + ++I + D
Sbjct: 20381 YTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDAD- 20439
Query: 898 EIDSGDYKCVASNSAGKSSHGARVTI 923
++SG Y+ N+ G +S RV I
Sbjct: 20440 RLNSGCYELKLRNAMGSASATIRVQI 20465
Score = 38.7 bits (86), Expect = 0.23
Identities = 29/129 (22%), Positives = 54/129 (41%), Gaps = 4/129 (3%)
Query: 796 KVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEP-PLFINRFQEITVKEKGTIKLVA 854
+ K++ + + A N G+ E + + VE E A L + + V+ +I++
Sbjct: 14242 QTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFV 14301
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+ P P +TW ++N + I E+ L+I + D+G + N AGK
Sbjct: 14302 PIKGRPAPEVTWTKDNINLKNRANIENT---ESFTLLIIPECNRYDTGKFVMTIENPAGK 14358
Query: 915 SSHGARVTI 923
S V +
Sbjct: 14359 KSGFVNVRV 14367
Score = 38.7 bits (86), Expect = 0.23
Identities = 56/251 (22%), Positives = 103/251 (41%), Gaps = 28/251 (11%)
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
T K + TY V ++ E ++ + + G EP + EP+K+ L+
Sbjct: 14419 TATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDS-LNIM 14477
Query: 758 VVGNPRPTITWCKNNKP---------VKALPTKSDGDTHSITI------LKPKKVKDEGV 802
+ ++ W K ++A SD TH T+ ++ +E
Sbjct: 14478 DITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYT 14537
Query: 803 YTLKAENSEGIA--ETSAVITVEEPTEENAEPPLFINR-FQEITVKEKG-TIKLVARVTR 858
+ + A NS G + S + V+E T P L + +Q++ + + G IK+ V
Sbjct: 14538 FQVMAVNSAGRSAPRESRPVIVKEQT---MLPELDLRGIYQKLVIAKAGDNIKVEIPVLG 14594
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVIT-NVDSEIDSGDYKCVASNSAGKSSH 917
P P++TW + ++I+ ++ + NF+ ++ N DSG Y A N G+
Sbjct: 14595 RPKPTVTWKKGDQILKQTQRV--NFETTATSTILNINECVRSDSGPYPLTARNIVGEV-- 14650
Query: 918 GARVTIDVEKV 928
G +TI V +
Sbjct: 14651 GDVITIQVHDI 14661
Score = 38.7 bits (86), Expect = 0.23
Identities = 31/120 (25%), Positives = 52/120 (43%), Gaps = 7/120 (5%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPP---LFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A NSEG+ E A++ E+ PP L + + +T++ T++L + P P
Sbjct: 15336 AMNSEGLGEP-ALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPE 15394
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ W R++ +I L++ NV + DSG Y NS+G S V +
Sbjct: 15395 VKWARDHGESLDKASIEST--SSYTLLIVGNV-NRFDSGKYILTVENSSGSKSAFVNVRV 15451
Score = 38.7 bits (86), Expect = 0.23
Identities = 35/145 (24%), Positives = 58/145 (40%), Gaps = 8/145 (5%)
Query: 784 GDTHSITILKPKKV-KDEGVYTLKAENSEGIAET----SAVITVEEPTEENAEPPLFINR 838
G T +T + V K E + +KA+N G +E S+VI E E A+ N
Sbjct: 22099 GHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITN- 22157
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSE 898
Q IT K + ++ P P +TW + ++ ++ + L + +
Sbjct: 22158 -QLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKD-SMR 22215
Query: 899 IDSGDYKCVASNSAGKSSHGARVTI 923
DSG Y N+AG + V +
Sbjct: 22216 GDSGRYFLTLENTAGVKTFSVTVVV 22240
Score = 38.7 bits (86), Expect = 0.23
Identities = 26/104 (25%), Positives = 43/104 (41%), Gaps = 1/104 (0%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +E + H G V + G P P ITW + +I + +Q+ + +
Sbjct: 24531 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVF 24590
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAPLSDHGSEMT 612
V +DAG + AKN G T EL + + P G +++
Sbjct: 24591 PNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVS 24634
Score = 38.3 bits (85), Expect = 0.30
Identities = 39/181 (21%), Positives = 75/181 (41%), Gaps = 12/181 (6%)
Query: 1507 GVPQPKVTWYRDGKKL---KTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G P P+ W+ DG+++ T K + + +A N G
Sbjct: 1436 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1495
Query: 1562 SCVVGIQ--QKPVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK- 1617
S ++ ++ + V + E +K + K G + + G P P+++W KN + + K
Sbjct: 1496 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPNPDIVWLKNSDIIVPHKY 1555
Query: 1618 -EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLKVYDKPSKPEGPVI 1674
+ I + + ++I S+ YT A N AG T+ +V ++V +PE +I
Sbjct: 1556 PKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLI 1615
Query: 1675 M 1675
+
Sbjct: 1616 I 1616
Score = 38.3 bits (85), Expect = 0.30
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 9/97 (9%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK--NNKPVKALPTKSDGDTHSI--- 789
P I+ + M V +G +V + A++ G P PT+TW K KP P D + +
Sbjct: 9620 PPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD 9679
Query: 790 ---TILKPK-KVKDEGVYTLKAENSEGIAETSAVITV 822
T++ P+ + D G+YT+ A N+ G A + V
Sbjct: 9680 DTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9716
Score = 38.3 bits (85), Expect = 0.30
Identities = 49/181 (27%), Positives = 78/181 (43%), Gaps = 13/181 (7%)
Query: 640 PKAQY-VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKIT 698
P AQ V G ++ LE P+P I+WL G + E + + + L I
Sbjct: 21072 PGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENK----ITLSIK 21127
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQV 758
N KK G YTV+ N ++PI + I G P+ P++ ++ +SVILS V
Sbjct: 21128 NAKKEHGGKYTVILDNAVCRIAVPITV-ITLGPPSKPK--GPIRFDEIK-ADSVILSWDV 21183
Query: 759 VGNPRPTITWCKNNKPVKALPTKSDGDTHSI---TILKPKKVKD-EGVYTLKAENSEGIA 814
+ C + + + T S+ T P VKD E + ++AEN G++
Sbjct: 21184 PEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVS 21243
Query: 815 E 815
+
Sbjct: 21244 Q 21244
Score = 38.3 bits (85), Expect = 0.30
Identities = 21/70 (30%), Positives = 34/70 (48%), Gaps = 3/70 (4%)
Query: 1592 VTAVIEG--IPPPEVIWYKNGNKLENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEAS 1648
+T V+E + EV WYK+G KL+ + + + + T ++I L S +Y E S
Sbjct: 26238 LTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEIS 26297
Query: 1649 NTAGTSSVEV 1658
GTS +
Sbjct: 26298 GEGGTSKTNL 26307
Score = 37.9 bits (84), Expect = 0.39
Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV+F + G P P W + IK + + + D+ + + L I+ D G +
Sbjct: 11028 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFS-SVLTIKNCLRRDTGEYQI 11086
Query: 584 VAKNAAGFASSTTELIV 600
NAAG + L V
Sbjct: 11087 TVSNAAGSKTVAVHLTV 11103
Score = 37.9 bits (84), Expect = 0.39
Identities = 32/156 (20%), Positives = 69/156 (44%), Gaps = 10/156 (6%)
Query: 673 EIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
+ + +EN + + + S +T K++ T+ V A N GE + + + +
Sbjct: 13424 DFLTEENKWQRVMKSLSLQYSAKDLTEGKEY---TFRVSAENENGEGTPSEITVVARDDV 13480
Query: 733 EPPQV-IEPLKSM--IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI 789
P + ++ L + + ++ + L + G P P+++W K P+ A T+ ++ ++
Sbjct: 13481 VAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPL-ATDTRVSVESSAV 13539
Query: 790 T---ILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
I+ + D G YT+ +N G E + I V
Sbjct: 13540 NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 13575
Score = 37.9 bits (84), Expect = 0.39
Identities = 24/116 (20%), Positives = 46/116 (39%), Gaps = 5/116 (4%)
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEIT--VKEKGTIKLVARVT 857
E + + AEN G S + V ++ P L + ++ KE +L +
Sbjct: 13453 EYTFRVSAENENGEGTPSEITVVAR--DDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIK 13510
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P PS++W + + ++ ++ N L++ + D+G Y N AG
Sbjct: 13511 GKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKS-DAGKYTITLKNVAG 13565
Score = 37.9 bits (84), Expect = 0.39
Identities = 37/131 (28%), Positives = 59/131 (45%), Gaps = 9/131 (6%)
Query: 798 KDEGVYTLKAENSEGIAETSAV---ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
K E + + A N G+ E + V I VEE E + L + + I ++ G+++L
Sbjct: 16409 KHEYNFRICAINKAGVGEHADVPGPIIVEEKLEA-PDIDLDLELRKIINIRAGGSLRLFV 16467
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+ P P + W + + I + I + LV+ NV + DSG Y NS+G
Sbjct: 16468 PIKGRPTPEVKWGKVDGEIRDAAII--DVTSSFTSLVLDNV-NRYDSGKYTLTLENSSGT 16524
Query: 915 SSHGARVTIDV 925
S A VT+ V
Sbjct: 16525 KS--AFVTVRV 16533
Score = 37.5 bits (83), Expect = 0.52
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 9/109 (8%)
Query: 509 APIFVEKLRPKHT------PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
A +FVE L T P+ T FEC+V + P + W + I+ S+ F++
Sbjct: 2829 AKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVV-Q 2886
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASST-TELIVEAPLSDHGSE 610
+ L+I ED+ +T V N A+ T T +++ + L D +E
Sbjct: 2887 GKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLKDINAE 2935
Score = 37.5 bits (83), Expect = 0.52
Identities = 20/81 (24%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ E V G P P W + + S ++ D + + L+I++V +D+G ++
Sbjct: 12416 GKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSS-SILIIKDVTRKDSGYYSL 12474
Query: 584 VAKNAAGFASSTTELIV-EAP 603
A+N++G + +++V +AP
Sbjct: 12475 TAENSSGTDTQKIKVVVMDAP 12495
Score = 37.5 bits (83), Expect = 0.52
Identities = 29/125 (23%), Positives = 54/125 (43%), Gaps = 5/125 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFI---NRFQEITVKEKGTIKLVA-RVTR 858
+ ++A+N+ G + T ++ E P + +T+K TI L A +
Sbjct: 13849 FRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILG 13908
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P+P +W + + I PS+ ITQ ++ + D+G+Y A+N G
Sbjct: 13909 KPLPKSSWSKAGKDIRPSD-ITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH 13967
Query: 919 ARVTI 923
+VT+
Sbjct: 13968 VKVTV 13972
Score = 37.5 bits (83), Expect = 0.52
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 3/68 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV-IREVFPEDAGTFT 582
G ++ E V G P+P +TW + I+K +Q ++ ++ +T++ I E D+G +
Sbjct: 14583 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQ--RVNFETTATSTILNINECVRSDSGPYP 14640
Query: 583 CVAKNAAG 590
A+N G
Sbjct: 14641 LTARNIVG 14648
Score = 37.5 bits (83), Expect = 0.52
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 4/88 (4%)
Query: 838 RFQEITVKEKG-TIKLVARVTRNPVPSITWYR-NNEIISPSETITQNFDGENIELVITNV 895
+F++ V G T +L A V P+P+I W R + EI + +N D + L+I
Sbjct: 17133 KFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFK--ALLIVKD 17190
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTI 923
ID G Y ASN AG S V +
Sbjct: 17191 AIRIDGGQYILRASNVAGSKSFPVNVKV 17218
Score = 37.5 bits (83), Expect = 0.52
Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T + E V G P P I W R I+ S ++ + D A L++++ D G +
Sbjct: 17143 GETFRLEADVHGKPLPTIEWLRGDKEIEESARCEI-KNTDFKALLIVKDAIRIDGGQYIL 17201
Query: 584 VAKNAAGFAS 593
A N AG S
Sbjct: 17202 RASNVAGSKS 17211
Score = 37.5 bits (83), Expect = 0.52
Identities = 36/141 (25%), Positives = 62/141 (43%), Gaps = 9/141 (6%)
Query: 789 ITILKPKKVKDEGVYTLK--AENSEGIAETSAVITVEEPTEENAEPPLFINRF--QEITV 844
+T + K+ + Y ++ A N G+ E ++V +P ++ P L ++ + I V
Sbjct: 17480 VTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVV 17539
Query: 845 KEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDY 904
+ G+ ++ P P ITW R + I + + +L I N D D+G Y
Sbjct: 17540 RAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVN--YTQLSIDNCDRN-DAGKY 17596
Query: 905 KCVASNSAGKSSHGARVTIDV 925
NS+G S A VT+ V
Sbjct: 17597 ILKLENSSGSKS--AFVTVKV 17615
Score = 37.5 bits (83), Expect = 0.52
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 13/125 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREG---EASLPIVLKIKTGEKEPPQV---IEPLKSMIVRQGE 750
+T +K+ E + + A+N EG A+LP + + EPP++ + K +++R
Sbjct: 18568 VTKLKENTEYNFRICAINSEGVGEPATLPGSV-VAQERIEPPEIELDADLRKVVVLRASA 18626
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGD-THSITILKPKKVK--DEGVYTLKA 807
++ L + G P P + W K L ++ + T S T+L V D G Y L
Sbjct: 18627 TLRLFVTIKGRPEPEVKW---EKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTL 18683
Query: 808 ENSEG 812
EN+ G
Sbjct: 18684 ENNSG 18688
Score = 37.5 bits (83), Expect = 0.52
Identities = 17/73 (23%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKE--YNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
V G P PEV W G K+ + ++ ++I + + + I ++++ YT+ N
Sbjct: 26851 VACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 26910
Query: 1650 TAGTSSVEVTLKV 1662
G+ S V + +
Sbjct: 26911 EFGSDSATVNIHI 26923
Score = 37.1 bits (82), Expect = 0.69
Identities = 15/50 (30%), Positives = 24/50 (48%)
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
I E++ + +KN + C G P PK+ WY+DGK++K
Sbjct: 1237 ISESEAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK 1286
Score = 37.1 bits (82), Expect = 0.69
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 5/72 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFR-QTAIIKPSQDFQMYYDD----DNVATLVIREVFPEDA 578
G V V G P P+I W + +T I KP+ Q+ ++ + L I + ED
Sbjct: 8916 GEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDK 8975
Query: 579 GTFTCVAKNAAG 590
GT+T A N G
Sbjct: 8976 GTYTVTASNRLG 8987
Score = 36.7 bits (81), Expect = 0.91
Identities = 23/58 (39%), Positives = 28/58 (48%), Gaps = 4/58 (6%)
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN---SKCTAI-LTV 1191
+W DGSEI+ H + D L I +C D GEY V N SK A+ LTV
Sbjct: 11046 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTV 11103
Score = 36.3 bits (80), Expect = 1.2
Identities = 30/136 (22%), Positives = 60/136 (44%), Gaps = 12/136 (8%)
Query: 937 SYETEEGKTVILECQT--SHTVSTKWYHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXD 993
S++ EG+T + + T W+H+ ++I + H+ +I+E D
Sbjct: 1419 SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSD 1478
Query: 994 VGVIKCIVKDQ----ETSTMLVVK----ETIPEFIRKLQDFEVKEKDVAILEVEINSE-T 1044
G + +++ S +L V+ + P F+ KL++ +KE ++V
Sbjct: 1479 SGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPN 1538
Query: 1045 ADVVWERDGEIIKPKK 1060
D+VW ++ +II P K
Sbjct: 1539 PDIVWLKNSDIIVPHK 1554
Score = 36.3 bits (80), Expect = 1.2
Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 8/107 (7%)
Query: 822 VEEPT--EENAEPPLFI---NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
V EP ++ EPP I N +E +K T++L A + P P +TW + +
Sbjct: 10706 VPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTK 10765
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
I G +E I N E D G Y N AG + +V +
Sbjct: 10766 ARIDVTPVGSKLE--IRNAAHE-DGGIYSLTVENPAGSKTVSVKVLV 10809
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G+ + + +P P W G EI DE+ +V E+D + SVL I N +
Sbjct: 11025 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTV--ETD--NFSSVLTIKNCLRRD 11080
Query: 705 EGTYTVVAVNREGEASLPIVLKI 727
G Y + N G ++ + L +
Sbjct: 11081 TGEYQITVSNAAGSKTVAVHLTV 11103
Score = 36.3 bits (80), Expect = 1.2
Identities = 20/77 (25%), Positives = 35/77 (45%), Gaps = 1/77 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ + G P P +TW + +K + ++N + L I++ ED G +
Sbjct: 15665 GEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENN-SLLTIKDACREDVGHYVV 15723
Query: 584 VAKNAAGFASSTTELIV 600
N+AG A T +IV
Sbjct: 15724 KLTNSAGEAIETLNVIV 15740
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/82 (28%), Positives = 35/82 (42%), Gaps = 3/82 (3%)
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD-GDTHSITILKPKKV--KDE 800
++V GE+ +L A + G P P + W K+ K ++ + + T T L K D
Sbjct: 18220 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 18279
Query: 801 GVYTLKAENSEGIAETSAVITV 822
G Y LK N G + V
Sbjct: 18280 GQYILKLSNVGGTKSIPITVKV 18301
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/81 (28%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS + + V G P P+I W + + + + Y AT VI+ D+G +T
Sbjct: 22565 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKR-ATAVIKFCDRSDSGKYTL 22623
Query: 584 VAKNAAGF-ASSTTELIVEAP 603
KNA+G A S ++++P
Sbjct: 22624 TVKNASGTKAVSVMVKVLDSP 22644
Score = 35.9 bits (79), Expect = 1.6
Identities = 27/79 (34%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQIT-WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
GS+ FEC V P IT W + + I+ S + D + L I +V DAG +T
Sbjct: 4636 GSSAIFECLVS--PSTAITTWMKDGSNIRESPKHRFIADGKD-RKLHIIDVQLSDAGEYT 4692
Query: 583 CVAKNAAGFASSTTELIVE 601
CV + +ST +L+VE
Sbjct: 4693 CVLRLGNKEKTSTAKLVVE 4711
Score = 35.9 bits (79), Expect = 1.6
Identities = 13/33 (39%), Positives = 22/33 (66%)
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
S+ V++G+ + L A + G+P PTITW K+ +
Sbjct: 8191 SLEVKRGDEIALDASISGSPYPTITWIKDENVI 8223
Score = 35.9 bits (79), Expect = 1.6
Identities = 29/134 (21%), Positives = 55/134 (41%), Gaps = 5/134 (3%)
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIK 851
+K K D Y + A N G + S +E A P L ++ ++T++
Sbjct: 10281 VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFA 10340
Query: 852 LVARVTRNPVPSITWYRNN-EIISPSETITQNFDGENIELVITNVDSE-IDSGDYKCVAS 909
L R + P P ++W+++ +++ T + L + + ++ DSG Y V
Sbjct: 10341 LTGRYSGKPKPKVSWFKDEADVLEDDRT---HIKTTPATLALEKIKAKRSDSGKYCVVVE 10397
Query: 910 NSAGKSSHGARVTI 923
NS G +V +
Sbjct: 10398 NSTGSRKGFCQVNV 10411
Score = 35.9 bits (79), Expect = 1.6
Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 10/86 (11%)
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKN-------NKPVKALPTKSDGDTHSITILKPKK 796
+ V+ G+++ L A V G P P + W K+ P + T++D S+T K K+
Sbjct: 11714 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLT--KAKR 11771
Query: 797 VKDEGVYTLKAENSEGIAETSAVITV 822
D G Y + A N+ G A + V
Sbjct: 11772 -SDGGKYVVTATNTAGSFVAYATVNV 11796
Score = 35.9 bits (79), Expect = 1.6
Identities = 14/53 (26%), Positives = 28/53 (52%)
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+V WY +LEN ++Y IT ++ +++ +K++ + Y + N G S
Sbjct: 25102 QVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDS 25154
Score = 35.5 bits (78), Expect = 2.1
Identities = 22/98 (22%), Positives = 42/98 (42%), Gaps = 3/98 (3%)
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+QKP I + E ++ G+ + G P P+V WY NG + K + + +
Sbjct: 1792 KQKPDIVLYPEPVRVLE--GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV-RYDGI 1848
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
+ I + K + + + A N G +V L++ +
Sbjct: 1849 HYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQR 1886
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/103 (24%), Positives = 46/103 (44%), Gaps = 7/103 (6%)
Query: 505 EQSMAPIF---VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
E+ MAP F E R G +++ ++G P P++TW + +K + + +
Sbjct: 14272 EREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIE---N 14328
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
++ L+I E D G F +N AG S + +++ P
Sbjct: 14329 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTP 14371
Score = 35.5 bits (78), Expect = 2.1
Identities = 24/101 (23%), Positives = 39/101 (38%), Gaps = 1/101 (0%)
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
P I ++ K G L P P+ +W K + + + K S D ++ +LT+
Sbjct: 24036 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTV 24095
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-PPGKP 1387
E D G+Y N G + + + P PG P
Sbjct: 24096 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP 24136
Score = 35.5 bits (78), Expect = 2.1
Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 4/80 (5%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEI-NSETADVVWERDG-EIIKPKKNKYDFEKRGHIRKL 1074
P ++++D K + A L +I D+ W R G E+I+ +K K + R H L
Sbjct: 24036 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT--L 24093
Query: 1075 YIRNTSVHDEGEYSCILRDE 1094
+ DEG Y+CI +E
Sbjct: 24094 TVMTEEQEDEGVYTCIATNE 24113
Score = 35.1 bits (77), Expect = 2.8
Identities = 37/161 (22%), Positives = 67/161 (41%), Gaps = 12/161 (7%)
Query: 446 YILD--TSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDKLPVFEKPTS 503
Y++D T W V K L+ + A+ L + YT + + NE + P +
Sbjct: 13421 YVVDFLTEENKWQRVMKSLSLQYS---AKDLTEGKEYTFRVSAE-NENGEGTPSEITVVA 13476
Query: 504 EEQSMAPIFVEKLRPKH---TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
+ +AP K P + S + + ++G P P ++W + + + D ++
Sbjct: 13477 RDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPL--ATDTRVSV 13534
Query: 561 DDDNV-ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ V TL++ + DAG +T KN AG T + V
Sbjct: 13535 ESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 13575
Score = 35.1 bits (77), Expect = 2.8
Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 8/107 (7%)
Query: 634 PTFSKKPKAQ---YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
P S PK + V G +LE + P PD+ W G+E+ E + +E +
Sbjct: 18208 PNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKEL---EETAARMEIKSTI 18264
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI--KTGEKEPP 735
+ L + + + G Y + N G S+PI +K+ + G E P
Sbjct: 18265 QKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGP 18311
Score = 35.1 bits (77), Expect = 2.8
Identities = 19/81 (23%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS + + G P P++TW + +K + + D TL +++ D+G +
Sbjct: 22165 GSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDR-TTLTVKDSMRGDSGRYFL 22223
Query: 584 VAKNAAGFAS-STTELIVEAP 603
+N AG + S T +++ P
Sbjct: 22224 TLENTAGVKTFSVTVVVIGRP 22244
Score = 35.1 bits (77), Expect = 2.8
Identities = 24/90 (26%), Positives = 43/90 (47%), Gaps = 5/90 (5%)
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT---ILKPKK 796
P K++ V G V L + G P P +W ++ + +TH+ ++
Sbjct: 23247 PQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRE-SERVTVETHTKVAKLTIRETT 23305
Query: 797 VKDEGVYTLKAENSEG-IAETSAVITVEEP 825
++D G YTL+ +N G +ET VI +++P
Sbjct: 23306 IRDTGEYTLELKNVTGTTSETIKVIILDKP 23335
Score = 35.1 bits (77), Expect = 2.8
Identities = 39/180 (21%), Positives = 74/180 (41%), Gaps = 17/180 (9%)
Query: 1218 VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
+E D++ VTWY +E++EK+ + + L ++ T+ D Y C +++
Sbjct: 25094 IENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGED 25153
Query: 1278 KLKVEV-VEFPPKIVDY---EREYRIKRGSDVTLLVDYQ---AFPQPNDEWIVNSKI--- 1327
E+ V+ ++ DY +IKR +D L++ P N V +
Sbjct: 25154 SSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFG 25213
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVEN-------TDAGIYKLRLENNCGHADVEMNVTILDK 1380
+ H +P + + IK +N +D G+Y+L + + D E V +K
Sbjct: 25214 VTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 25273
Score = 34.7 bits (76), Expect = 3.7
Identities = 25/121 (20%), Positives = 53/121 (43%), Gaps = 2/121 (1%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ +KA N +G ++ + + +P L + F +++ +K+ V P P
Sbjct: 17786 FRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLP-FNTYSIQAGEDLKIEIPVIGRPRP 17844
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+I+W ++ E + + + + L I + + D G Y A+NSAG ++ V
Sbjct: 17845 NISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKD-DFGKYTVTATNSAGTATENLSVI 17903
Query: 923 I 923
+
Sbjct: 17904 V 17904
Score = 34.7 bits (76), Expect = 3.7
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 641 KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNV 700
K + G+ + L + P P I W +G ++ S AI Y S+L + V
Sbjct: 22957 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLA-----SRAIIDTTESY-SLLIVDKV 23010
Query: 701 KKFQEGTYTVVAVNREGEASLPIVLKI 727
++ G YT+ A N+ G+ S +++K+
Sbjct: 23011 NRYDAGKYTIEAENQSGKKSATVLVKV 23037
Score = 34.3 bits (75), Expect = 4.9
Identities = 22/94 (23%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
PT + V EG + + A+P P ++W G+E+ + ++ +++D H+ +
Sbjct: 7890 PTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLT--MKND-HI-SA 7945
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L++ + G YT+ N+ G A+ I +K+
Sbjct: 7946 HLEVPKSVRADAGIYTITLENKLGSATASINVKV 7979
Score = 34.3 bits (75), Expect = 4.9
Identities = 37/130 (28%), Positives = 54/130 (41%), Gaps = 11/130 (8%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN---RFQEITVKEKGTIKLVARVTRN 859
+ +KA N G +E S + V +E P + + R I VK + + A VT
Sbjct: 8870 FRVKAVNEIGESEPSLPLNVVIQDDE-VPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGL 8928
Query: 860 PVPSITWYRNNEII-SPSET--ITQ---NFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P+P I W +N +I P++ IT+ + EL I E D G Y ASN G
Sbjct: 8929 PMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRE-DKGTYTVTASNRLG 8987
Query: 914 KSSHGARVTI 923
V +
Sbjct: 8988 SVFRNVHVEV 8997
Score = 34.3 bits (75), Expect = 4.9
Identities = 26/120 (21%), Positives = 52/120 (43%), Gaps = 4/120 (3%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFIN--RFQEITVKEKG-TIKLVARVTRNPVPS 863
A N+ G+ + T + +PP ++++ V G + K+ A + P+P+
Sbjct: 16018 ARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPT 16077
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
I W + ++ +S + + L + + +DSG+Y A N AG+ S V +
Sbjct: 16078 IQWIKGDQELSNTARLEIKSTDFATSLSVKDA-VRVDSGNYILKAKNVAGERSVTVNVKV 16136
Score = 34.3 bits (75), Expect = 4.9
Identities = 25/100 (25%), Positives = 39/100 (39%), Gaps = 4/100 (4%)
Query: 727 IKTGEKEPPQVIEPLKSMIV--RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG 784
IK + EP + + + ++ + G + + G P P +TW +K S
Sbjct: 22141 IKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSIT 22200
Query: 785 DTHSITIL--KPKKVKDEGVYTLKAENSEGIAETSAVITV 822
T T L K D G Y L EN+ G+ S + V
Sbjct: 22201 TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVV 22240
Score = 34.3 bits (75), Expect = 4.9
Identities = 18/67 (26%), Positives = 28/67 (41%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
++ P EV WY NG +L+ + + T + I + S Y +N G +S
Sbjct: 25900 VQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEAS 25959
Query: 1656 VEVTLKV 1662
TL V
Sbjct: 25960 DYATLDV 25966
Score = 33.9 bits (74), Expect = 6.4
Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 2/64 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T F+C++ Y + W+ + ++PS D + + V TL +R+V EDAG
Sbjct: 5713 GETATFDCELS-YEDIPVEWYLKGKKLEPS-DKVVPRSEGKVHTLTLRDVKLEDAGEVQL 5770
Query: 584 VAKN 587
AK+
Sbjct: 5771 TAKD 5774
Score = 33.9 bits (74), Expect = 6.4
Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 517 RPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT-LVIREVFP 575
R +H G T++ ++G P P++TW ++ + D V + L IR
Sbjct: 10729 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDR----DAPTKARIDVTPVGSKLEIRNAAH 10784
Query: 576 EDAGTFTCVAKNAAGFASSTTELIV 600
ED G ++ +N AG + + +++V
Sbjct: 10785 EDGGIYSLTVENPAGSKTVSVKVLV 10809
Score = 33.9 bits (74), Expect = 6.4
Identities = 18/81 (22%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G++V+ + G P P I W++ ++ + + ++A+++I++ ++G +
Sbjct: 20390 GTSVKLRAGISGKPAPTIEWYKDDKELQ-TNALVCVENTTDLASILIKDADRLNSGCYEL 20448
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+NA G AS+T + I++ P
Sbjct: 20449 KLRNAMGSASATIRVQILDKP 20469
Score = 33.9 bits (74), Expect = 6.4
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 3/72 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G++++ V G P P ITW +Q I S+ + ++ + L++ +V DAG +T
Sbjct: 22964 GASLRLMVSVSGRPPPVITWSKQ-GIDLASR--AIIDTTESYSLLIVDKVNRYDAGKYTI 23020
Query: 584 VAKNAAGFASST 595
A+N +G S+T
Sbjct: 23021 EAENQSGKKSAT 23032
Score = 33.9 bits (74), Expect = 6.4
Identities = 17/54 (31%), Positives = 28/54 (51%)
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
WF GS+++ S + + K KL I + + D GEY+ E+ N T T++
Sbjct: 23275 WFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIK 23328
Score = 33.5 bits (73), Expect = 8.5
Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 15/131 (11%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVL-KIK-TGEKEPPQVIEPLKS---MIVRQGES 751
+ N+K+ ++ + V AVN GE+ +I T +E P+V + + ++ + G
Sbjct: 9271 VPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQ 9330
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKA-------LPTKSDGDT---HSITILKPKKVKDEG 801
+ + A + G P P +W + K KA +P + +T S+ I+ K G
Sbjct: 9331 IRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTG 9390
Query: 802 VYTLKAENSEG 812
Y++ A+N G
Sbjct: 9391 KYSITAKNKAG 9401
Score = 33.5 bits (73), Expect = 8.5
Identities = 31/130 (23%), Positives = 53/130 (40%), Gaps = 9/130 (6%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN-RFQEITVKEKGT-IKLVARVTRNP 860
+ +KA N G +E S T+ EP +FI+ Q+ V + G+ I++ A + P
Sbjct: 9282 FRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRP 9341
Query: 861 VPSITWYRNNEI-------ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P +W + + + Q EN ++I +G Y A N AG
Sbjct: 9342 TPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAG 9401
Query: 914 KSSHGARVTI 923
+ + RV +
Sbjct: 9402 QKTANCRVKV 9411
Score = 33.5 bits (73), Expect = 8.5
Identities = 25/106 (23%), Positives = 47/106 (44%), Gaps = 7/106 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PP P+ + G + +E + P P W +E+V +++V ++D
Sbjct: 12401 LPPKILM-PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVH-KADS--- 12455
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPP 735
S+L I +V + G Y++ A N G + +V+ G +PP
Sbjct: 12456 SSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPP 12501
Score = 33.5 bits (73), Expect = 8.5
Identities = 18/69 (26%), Positives = 31/69 (44%), Gaps = 1/69 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + E V G P P + W + ++ + ++ D + LV ++ D+G +T
Sbjct: 14979 GEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKDSTRRDSGAYTL 15037
Query: 584 VAKNAAGFA 592
A N GFA
Sbjct: 15038 TATNPGGFA 15046
Score = 33.5 bits (73), Expect = 8.5
Identities = 53/198 (26%), Positives = 78/198 (39%), Gaps = 22/198 (11%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G D+ +E + P+P I W G + I+V D+ + L I K
Sbjct: 16744 VQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDL----TTLSIKETHKDD 16799
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G Y + N G+ + I + + + +PP+ P+K V ES+ LS NP
Sbjct: 16800 GGQYGITVANVVGQKTASIEI-VTLDKPDPPK--GPVKFDDV-SAESITLS----WNPPL 16851
Query: 765 TITWCK--NNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYTLK--AENSEG--IA 814
C+ N K T + D S T+ LK K+K Y + AEN G A
Sbjct: 16852 YTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFA 16911
Query: 815 ETSAVITVEEPTEENAEP 832
S I + P +E P
Sbjct: 16912 LESDPIVAQYPYKEPGPP 16929
Score = 33.5 bits (73), Expect = 8.5
Identities = 21/80 (26%), Positives = 42/80 (52%), Gaps = 4/80 (5%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
GSD++L+ + PEP I W KG++ + D V+++ +V+K + + G
Sbjct: 22565 GSDLVLDAAVGGKPEPKIIWT-KGDKEL-DLCEKVSLQYTGKRATAVIKFCD--RSDSGK 22620
Query: 708 YTVVAVNREGEASLPIVLKI 727
YT+ N G ++ +++K+
Sbjct: 22621 YTLTVKNASGTKAVSVMVKV 22640
>X90568-1|CAA62188.1|26926|Homo sapiens titin protein.
Length = 26926
Score = 298 bits (732), Expect = 1e-79
Identities = 200/685 (29%), Positives = 321/685 (46%), Gaps = 41/685 (5%)
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL-TIKKV 1350
D + ++ G + L V + P P W + ++ + +D KS T +
Sbjct: 13201 DLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRD----RIGLDIKSTDFDTFLRC 13256
Query: 1351 ENT---DAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENT 1407
EN DAG Y L LEN+CG + + V +LD P PP + EI S + W+ P
Sbjct: 13257 ENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPINVTVKEISKDSAYVTWEPPIID 13316
Query: 1408 GNSTIIYYVVEYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
G S II YVV+ ++ + W +V +KT + NL+ SY FR +A NE I D E
Sbjct: 13317 GGSPIINYVVQKRDAERKSWSTVTTECSKTSFRVPNLEEGKSYFFRVFAENEYGIGDPGE 13376
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITT--------EPNEDIELTCIFGGVPQPKVTWYRD 1518
T + +K ++ P V+ +++++ +P+ D + I G V +
Sbjct: 13377 TRD---AVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGG-SRIIGYVVDFLTEENKW 13432
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE 1578
+ +K+ Y + ++ A N++GE S + + + V+ +
Sbjct: 13433 QRVMKSLSLQYSAKDLTEGKEYT------FRVSAENENGEGTPSEITVVARDDVVAPDLD 13486
Query: 1579 -----DIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
D+ K + + I+G P P V W K + L D ++ + + + +
Sbjct: 13487 LKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVY 13546
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDD 1693
+ ++S + KYTI N AGT +++KV KP P GP+ E++ E++T++W PP DD
Sbjct: 13547 DCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDD 13606
Query: 1694 GGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEAL 1753
GG E+T Y +EK + NN+W+ A + T+ + +L+E EY FRV A+N G E L
Sbjct: 13607 GGSEITNYILEKRDSVNNKWVTCASAVQKT-TFRVTRLHEGMEYTFRVSAENKYGVGEGL 13665
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-K 1812
+SEPIV + DVP + ++SV +TW +K GGSPI Y +E K+
Sbjct: 13666 KSEPIVARHPFDVPD-APPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLL 13724
Query: 1813 WKXXXXX--XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR 1870
WK ++ L+ Y+FR+ A N G P + + + PP +P
Sbjct: 13725 WKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPE 13784
Query: 1871 NFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENI 1930
V T SVTL WTEP+ +GG +T YI+E + + KSW K V + ++
Sbjct: 13785 ---VINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDL 13841
Query: 1931 KEKDEIIFRISAENTVG-VSLPTES 1954
E + FRI A+NT G +S P+ES
Sbjct: 13842 VEGGKYEFRIRAKNTAGAISAPSES 13866
Score = 287 bits (705), Expect = 2e-76
Identities = 345/1472 (23%), Positives = 588/1472 (39%), Gaps = 117/1472 (7%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F+K V E I L C V+ P ++ W EEI+ + E +L
Sbjct: 5968 FTKNLANIEVSETDTIKLVCE-VSKPGAEVIWYKGDEEIIETGRYEILTEGRKR----IL 6022
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
I N G Y + + K+K E + +P +++ + +GE
Sbjct: 6023 VIQNAHLEDAGNYNCRLPSSRTDG------KVKVHELAAEFISKP-QNLEILEGEKAEFV 6075
Query: 756 AQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ P + W +++K +++ +DG + ++K ++D G Y + G
Sbjct: 6076 CSISKESFP-VQWKRDDKTLESGDKYDVIADGKKR-VLVVKDATLQDMGTYVVMV----G 6129
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
A +A +TV E + ++ VKE+ + V + W+RN E
Sbjct: 6130 AARAAAHLTVIEKLR-------IVVPLKDTRVKEQQEVVFNCEVNTEGAKA-KWFRNEEA 6181
Query: 873 ISPSET--ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-SHGARVTIDVEKVT 929
I S I Q + + ++D D +Y +N G++ A + ++ E +
Sbjct: 6182 IFDSSKYIILQKDLVYTLRIRDAHLD---DQANYNVSLTNHRGENVKSAANLIVEEEDLR 6238
Query: 930 FVKHLQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
V+ L K ET E K+V C+ + V+ KW N +E+ D+R + +
Sbjct: 6239 IVEPL-KDIETMEKKSVTFWCKVNRLNVTLKWTKNGEEVP-FDNRVSYRVDKYKHMLTIK 6296
Query: 989 XXXX-DVG-VIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD 1046
D G I +D+ + +L++ E EF+ L+D V E D A+ +++ E A+
Sbjct: 6297 DCGFPDEGEYIVTAGQDKSVAELLII-EAPTEFVEHLEDQTVTEFDDAVFSCQLSREKAN 6355
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELP 1106
V W R+G IK K KY FEK G I +L I++ + DE EY+C + D A + V E+P
Sbjct: 6356 VKWYRNGREIKEGK-KYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIP 6414
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
EII Q+ G F EL K V+W ++ + + Q+ +GK +L+I
Sbjct: 6415 VEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQIC 6474
Query: 1167 DCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
D D GEY + + A L + ++ + LV + LT+ +P +
Sbjct: 6475 DIKPRDQGEYRFIAKDKEARAKLELAAAP---KIKTADQDLV-VDVGKPLTMVVPYDAYP 6530
Query: 1226 --DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKV 1281
+ W+K+ E T+ + ++ + I + + D+ Y VL + K+ + +
Sbjct: 6531 KAEAEWFKEN---EPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINL 6587
Query: 1282 EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPND--EWIVNSKIIKKCKHTKPSID 1339
+V++ P + + E +V+L + + ++V + IK+ +
Sbjct: 6588 KVIDVPGPVRNLEVTETFD--GEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDR 6645
Query: 1340 SKSASLTIKKVENTDAG-IYKLRLENNCGHAD-VEMNVTI-----LDKPSPPGKPNILEI 1392
++S T+ ++ ++++ N G + VE + + D P PP I ++
Sbjct: 6646 AESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDV 6705
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYR 1450
+ +++ W+ PE G + I YV+E ++ + W + + S + ++ Y
Sbjct: 6706 NRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYS 6765
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE-DIELTCIFGGVP 1509
FR A N + + S T + KV + SP V + T + E GG P
Sbjct: 6766 FRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSP 6825
Query: 1510 ----------QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
+ K W R KL + TY+ Y+ A N G
Sbjct: 6826 ILGYIIERCEEGKDNWIRCNMKL-VPELTYK------VTGLEKGNKYLYRVSAENKAGVS 6878
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE------GIPPPEVIWYKNGNKL 1613
+ S ++G + K G E +V I G P P W L
Sbjct: 6879 DPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVL 6938
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
E + T + + I +RS YT++ N T S E+ + V +PS P+ +
Sbjct: 6939 ETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPK-EL 6997
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNE 1733
+I+++SV + W+PP DDGG LT Y +EK E W KV D D+E + + L +
Sbjct: 6998 KFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLE-FTVPDLVQ 7056
Query: 1734 NCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE 1792
EY+F+V A+N G E A EP+ + T VP N S+++TW P +
Sbjct: 7057 GKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTAN-SIFLTWDPPK 7115
Query: 1793 KNGGSPIIDYKVEIKQEGK-KWKX-XXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+GGS I Y VE G KW + L Y +R+ N G S P
Sbjct: 7116 NDGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKTLNRQGASKP 7175
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK 1910
++I T P + + + K P + G P E K
Sbjct: 7176 SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKP------EPKI---- 7225
Query: 1911 SWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATV----- 1965
+WTK + IEN+ +K + S + G + E+ +V A V
Sbjct: 7226 TWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI-IEAVNVCGRATAVVEVNVL 7284
Query: 1966 --PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
P PP A +I V + + +W P DGG+ + Y + R +W ++ V
Sbjct: 7285 DKPGPPAA-FDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSST-VKD 7342
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
F L N Y+ R+ A N G EP+++
Sbjct: 7343 TNFKATKLIPNKEYIFRVAAENMYGAGEPVQA 7374
Score = 283 bits (695), Expect = 4e-75
Identities = 321/1444 (22%), Positives = 574/1444 (39%), Gaps = 102/1444 (7%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G +C L + + + W KG+++ P + + E +H L + +VK
Sbjct: 5710 VTAGETATFDCEL-SYEDIPVEWYLKGKKLEPSDKVVPRSEGKVH----TLTLRDVKLED 5764
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP-QVIEPLKSMIVRQGESVILSAQVVGNPR 763
G + A + + A+L + KEPP + +PL+ V +G + +L +V
Sbjct: 5765 AGEVQLTAKDFKTHANLFV--------KEPPVEFTKPLEDQTVEEGATAVLECEV-SREN 5815
Query: 764 PTITWCKNNKPV---KALPTKSDGDTHSITI--LKPKKVKDEGVYTLKAENSEGIAETSA 818
+ W KN + K +DG + I P+ +K YT A++ + TS
Sbjct: 5816 AKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIK---TYTCDAKDFK----TSC 5868
Query: 819 VITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET 878
+ V P E F+ ++ V+EK + ++R + W+++ I +
Sbjct: 5869 NLNVVPPHVE------FLRPLTDLQVREKEMARFECELSRENA-KVKWFKDGAEIKKGKK 5921
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
G + +++ N D +Y C + ++S +T+ E+ F K+L +
Sbjct: 5922 YDIISKGA-VRILVINKCLLDDEAEYSCEVRTA--RTS--GMLTVLEEEAVFTKNLA-NI 5975
Query: 939 ETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
E E T+ L C+ S WY +EI EI+ EGR D G
Sbjct: 5976 EVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNY 6035
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
C + T + V E EFI K Q+ E+ E + A I+ E+ V W+RD + ++
Sbjct: 6036 NCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLE 6095
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
+KYD G R L +++ ++ D G Y ++ A +TV+E I+ L++ +
Sbjct: 6096 -SGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTR 6153
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + + F E+ A +WF++ I S+ + L+I D LDD Y+
Sbjct: 6154 VKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYN 6213
Query: 1178 CEVGNS-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
+ N K A L VEE + L + + + + ++ + + W K
Sbjct: 6214 VSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWC-KVNRLNVTLKWTKN 6272
Query: 1233 KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
+ + + D K L I+ C D+ EY KS +L + +E P + V+
Sbjct: 6273 GEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLI--IEAPTEFVE 6330
Query: 1293 YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
+ + + D + N +W N + IK+ K K D L IK
Sbjct: 6331 HLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRL 6389
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTI 1412
D Y +E+ A + + ++ PP +ILE + + + ++
Sbjct: 6390 DDECEYACGVEDRKSRARLFVEEIPVEIIRPP--QDILEAPGADVVFLAELNKDKVEVQW 6447
Query: 1413 IYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
+ + + D + +S I + Q + YRF I+ E +
Sbjct: 6448 LRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRF---------IAKDKEARAKLE 6498
Query: 1473 VIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA-TYEN 1531
+ KI++ +++ + + + + + P+ + W+++ + L T T
Sbjct: 6499 LAAAPKIKTAD-----QDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAE 6553
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH--KVGDE 1589
+ YK + N HG+ E + + P + N ++ + +V
Sbjct: 6554 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPG-PVRNLEVTETFDGEVSLA 6612
Query: 1590 WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSK-YTIEA 1647
W G ++I Y + K + + T S + L++ + + A
Sbjct: 6613 WEEPLTDGG---SKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSA 6669
Query: 1648 SNTAGTSS-VEVTLKV-----YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
N GT VE V YD P P V + +++R V++ W+PP DGG E+T Y
Sbjct: 6670 RNRVGTGEPVETDNPVEARSKYDVPGPPLN-VTITDVNRFGVSLTWEPPEYDGGAEITNY 6728
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV-I 1760
IE + + RW V + + + + E EY FRV AQN +G + + P V +
Sbjct: 6729 VIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKV 6788
Query: 1761 KTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KW--KXXX 1817
++ PS + SV + W P K+GGSPI+ Y +E +EGK W
Sbjct: 6789 ADPIERPSPPVNLTSSDQTQS-SVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMK 6847
Query: 1818 XXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN-FVVSE 1876
++ L Y +R+ A N+ G S P +T P+ + F
Sbjct: 6848 LVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGL 6907
Query: 1877 STSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEI 1936
+ P + P + K ++ K+ T+ + E I + D+
Sbjct: 6908 EVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTL-SAYAELVISPSERSDKG 6966
Query: 1937 IFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM--VGSNIVMTSWGTPEWDG 1994
I+ + EN V +++ E V + P+AP E++ + + V +W P+ DG
Sbjct: 6967 IYTLKLENRV--------KTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDG 7018
Query: 1995 GAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
G+PL GY + R+V++ W +V V L+F + DL + Y+ ++ ARN+ G EP
Sbjct: 7019 GSPLTGYVVEKREVSRKTWTKVMDF-VTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAY 7077
Query: 2055 SDEP 2058
DEP
Sbjct: 7078 VDEP 7081
Score = 276 bits (676), Expect = 7e-73
Identities = 202/711 (28%), Positives = 312/711 (43%), Gaps = 35/711 (4%)
Query: 1287 PPKIV---DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK-- 1341
PP+++ + RE IK G + L + P P W K + TK ID
Sbjct: 10718 PPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTW----KKEDRDAPTKARIDVTPV 10773
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
+ L I+ + D GIY L +EN G V + V +LDKP PP + EI S + W
Sbjct: 10774 GSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTW 10833
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSI-QNLKTNSSYRFRAYAVNEVD 1460
EP + G S I YVVE +++ + +W + +K ++ ++L + Y FR A N+
Sbjct: 10834 KEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYG 10893
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF----GGVPQPK--VT 1514
ET + K + + P K L ++ + E + L GG P V
Sbjct: 10894 RGPFVETPKPIKALDP--LHPPGPPKDLHHVDVDKTE-VSLVWNKPDRDGGSPITGYLVE 10950
Query: 1515 WYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
+ +G + T N K G +T+ + Q+K V
Sbjct: 10951 YQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVP 11010
Query: 1574 TISNEDIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV 1629
D+K K G A+I G+P P W +G++++ D+ Y + T +SV
Sbjct: 11011 PSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV 11070
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKP 1689
+ IK R + +Y I SN AG+ +V V L V D P P GP+ + +++ E +TI W+P
Sbjct: 11071 LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQP 11130
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGF 1749
P DDGG + Y +EK + + W V+ + I L + CEY+FRV A+N +G
Sbjct: 11131 PKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLK-IPHLQKGCEYVFRVRAENKIGV 11189
Query: 1750 SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQE 1809
L+S P V K PS +N + ++W + +GGSPI Y +E ++
Sbjct: 11190 GPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT-VSWTLPKSDGGSPITGYYMERREV 11248
Query: 1810 GKKWKXXXXX--XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS 1867
KW R+ L TY+FR++A N G S P S D I + + PP
Sbjct: 11249 TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPG 11308
Query: 1868 QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC- 1926
P N + + + + L WT+P S+GGSPI Y++E + W +I + C
Sbjct: 11309 PPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINK--DELIRQCA 11366
Query: 1927 --IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ + E +E FRI A N VG P E + K + PP L++
Sbjct: 11367 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAK--DILHPPEVELDV 11415
Score = 265 bits (650), Expect = 1e-69
Identities = 176/667 (26%), Positives = 301/667 (45%), Gaps = 20/667 (2%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
+K G+ T+ V ++ P PN W ++ + + DS++ SLTI+ D+G Y
Sbjct: 19701 VKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTT-DSRT-SLTIENANRNDSGKY 19758
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE 1418
L ++N A + + V +LD P PP + ++ S + WD PEN G + + Y +E
Sbjct: 19759 TLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIE 19818
Query: 1419 YQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKET 1477
+E W+SV N + + NL+ + Y FR NE + +ET E K+ ++
Sbjct: 19819 KREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKP 19878
Query: 1478 ----KIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRX 1533
K+ ++ K ++T E + I V + ++ K AK+T+
Sbjct: 19879 SPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVS 19938
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ-QKPVITISNEDIKQKH-KVGDEWL 1591
+D E+ ++ Q + P I + N + + G
Sbjct: 19939 GLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLK 19998
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
V I G P P+V ++G L+ +N + I +KE + + +Y I A+N++
Sbjct: 19999 VDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITAANSS 20058
Query: 1652 GTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNN 1711
GT+ + + V D+P P GPV++ +I+ ESVT++W+PP DGG ++T Y + K E
Sbjct: 20059 GTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTA 20118
Query: 1712 RWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
W +V A V R + + KL EY FR+ A+N G S+ ++S + +K P
Sbjct: 20119 VWTEVSATVARTMMK--VMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYTTPG-P 20175
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXA--RIQ 1827
+ ES+ + W NGGS ++ Y +E+K W+ ++
Sbjct: 20176 PSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVT 20235
Query: 1828 KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWT 1887
+S Y+FR+YA N G P + + P PRN +++ + SV+L W
Sbjct: 20236 TISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEP---PRNVRITDISKNSVSLSWQ 20292
Query: 1888 EPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
+P +GGS IT YI+E + + WTK + + I + + + FR+ A N VG
Sbjct: 20293 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFTISGLTQNSQYEFRVFARNAVG 20352
Query: 1948 -VSLPTE 1953
+S P+E
Sbjct: 20353 SISNPSE 20359
Score = 262 bits (643), Expect = 7e-69
Identities = 220/864 (25%), Positives = 363/864 (42%), Gaps = 50/864 (5%)
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP 1287
TW V+E ++ + + L+I D+ YT L + T +++V
Sbjct: 6930 TWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIA 6989
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-------WIVNSKIIKKCKHTKPSIDS 1340
E ++ D+T + + P+D+ ++V + + + TK
Sbjct: 6990 RPSAPKELKF-----GDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFV 7044
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCG-----HADVEMNV-TILDKPSPPGKPNILEIDS 1394
T+ + ++K+ N CG + D +N+ T P PP + +
Sbjct: 7045 TDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTA 7104
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRA 1453
+SI + WD P+N G S I Y+VE + +W++ + + +T+ + L+ Y +R
Sbjct: 7105 NSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRV 7164
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVE-KPLKNITTEPNEDIELTCIFGGVPQPK 1512
+N S S TE + + + ++ K L +T + IEL G P+PK
Sbjct: 7165 KTLNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPK 7224
Query: 1513 VTWYRDGKKLKTAKA-TYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+TW + LK K T EN + Y A N G V +
Sbjct: 7225 ITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVL 7284
Query: 1569 QKP-------VITISNEDI----KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK 1617
KP + ++NE G + V+E +W+K + +++
Sbjct: 7285 DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKD-- 7342
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
T + T +I KE +++ A S + T K P P + +
Sbjct: 7343 ----TNFKATKLIPNKEYIFRVAAENMYGAGEPVQASPI--TAKYQFDPPGPPTRLEPSD 7396
Query: 1678 ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEY 1737
I++++VT+ W P DDGG +T Y +E+ +PD ++W++ + TY ++ L +Y
Sbjct: 7397 ITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKY 7456
Query: 1738 MFRVIAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGG 1796
FRV+A+N G + +S EPI+IK +D P + SV + W E +GG
Sbjct: 7457 RFRVLAENLAGPGKPSKSTEPILIKDPID-PPWPPGKPTVKDVGKTSVRLNWTKPEHDGG 7515
Query: 1797 SPIIDYKVEIKQEG-KKW-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSD 1854
+ I Y +E+ + G +W + + L Y FR+ A N+ G S P
Sbjct: 7516 AKIESYVIEMLKTGTDEWVRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPS 7575
Query: 1855 DKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTK 1914
D + + L PPS PR V T + LKWT PE +GGSPITNYI+E + V+ K W
Sbjct: 7576 DPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQT 7635
Query: 1915 IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHA-TVPSPPTAPL 1973
+ T + + + E +FR++AEN +G S TE + L K T P PP A L
Sbjct: 7636 VDTTVKDT-KCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYA-L 7693
Query: 1974 EIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSE 2033
+ V V W P+ DGG P+ Y I ++ T W++ GK F + D+ E
Sbjct: 7694 AVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIE 7753
Query: 2034 NHTYMIRIYARNEIGLSEPLESDE 2057
++ A NE G+ P E E
Sbjct: 7754 GTEVQFQVRAENEAGVGHPSEPTE 7777
Score = 260 bits (638), Expect = 3e-68
Identities = 196/695 (28%), Positives = 303/695 (43%), Gaps = 41/695 (5%)
Query: 1282 EVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SI 1338
E +E P +D E + I+ G + L V + P P +W K+ + + +
Sbjct: 16438 EKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW---GKVDGEIRDAAIIDV 16494
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
S SL + V D+G Y L LEN+ G + V +LD PSPP + EI S++
Sbjct: 16495 TSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVS 16554
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVN 1457
I W+ P G S I Y+VE +E + +V N K I L+ SY FR A N
Sbjct: 16555 ITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAEN 16614
Query: 1458 EVDISDASETTEYYKVIKETKIQSP-TVEKPLKNIT----TEPNEDIELTCIFGGVP-QP 1511
E I ++T + KV + + TV+ +N T+P D I V Q
Sbjct: 16615 EYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQA 16674
Query: 1512 KVTW-YRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET-SCVVGIQQ 1569
K + + + ++K+ +A N ++ +A N+ G + S V I
Sbjct: 16675 KHSEKWSECARVKSLQAVITN--------LTQGEEYLFRVVAVNEKGRSDPRSLAVPIVA 16726
Query: 1570 KPVITISNEDIKQKH-----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
K ++ D+K +VG + + I G P P + W K+G L+ N+T
Sbjct: 16727 KDLVI--EPDVKPAFSSYSVQVGQDLKMEVPISGRPKPTITWTKDGLPLKQTTRINVTDS 16784
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + IKE + +Y I +N G + + + DKP P+GPV ++S ES+T
Sbjct: 16785 LDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESIT 16844
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
+ W PPL GG ++T Y ++K + W + A V R T + KL EY FR+ A
Sbjct: 16845 LSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVAR--TTLKVTKLKTGTEYQFRIFA 16902
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
+N G S ALES+PIV + P I +S+ I W NGGSP+I Y
Sbjct: 16903 ENRYGQSFALESDPIVAQYPYKEPG-PPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYH 16961
Query: 1804 VEIKQEGK-KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
+E K+ W + Q L Y+FR+YA N +G + +
Sbjct: 16962 LERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVAR 17021
Query: 1861 KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG 1920
PP P +V + +TL+WT+P +GGS IT YI+E + + W K
Sbjct: 17022 DPCDPPGTPEPIMVKRN---EITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNV 17078
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVG-VSLPTES 1954
+ + + E FR+ A+N G +S P++S
Sbjct: 17079 IETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDS 17113
Score = 254 bits (623), Expect = 2e-66
Identities = 198/757 (26%), Positives = 326/757 (43%), Gaps = 35/757 (4%)
Query: 1218 VEIPDETLDVTWYK--KKSVIEDTEKFTLISDVK---KRTLIIRKCTEDDQCEYTCVLLD 1272
+E+ ++ D WY+ + I +TE FT + D+K K + + EY+ + +
Sbjct: 22881 LEMQEKDTD-QWYRVHTNATIRNTE-FT-VPDLKMGQKYSFRVAAVNVKGMSEYSESIAE 22937
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
+ ++++ +E D ++ I+ G+ + L+V P P W + + I
Sbjct: 22938 IEPVERIEIPDLELAD---DLKKTVTIRAGASLRLMVSVSGRPPPVITW--SKQGIDLAS 22992
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ L + KV DAG Y + EN G + V + D P P + E+
Sbjct: 22993 RAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEV 23052
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRF 1451
S+ I W+ P G + I Y+VE +E + +V +KT I L + + F
Sbjct: 23053 SRDSVTITWEIPTIDGGAPINNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMHYF 23112
Query: 1452 RAYAVNEVDISDASETTEYYKV----IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
R N I + ET++ V + K++ V K + E + + G
Sbjct: 23113 RVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGY 23172
Query: 1508 VPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE---TSCV 1564
V + K+ T K T ++ A N+ G E T
Sbjct: 23173 VLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYL---FRIRAQNEKGVSEPRETVTA 23229
Query: 1565 VGIQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
V +Q P I +S K H G + I G PPP W+ G+KL +
Sbjct: 23230 VTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVT 23289
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
+ T K + + I+E + +YT+E N GT+S + + + DKP P GP+ + EI
Sbjct: 23290 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDA 23349
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD-VDRDVETYCIQKLNENCEYMF 1739
S+TI W+PP DGG L+ Y +E+ + W+ V++ V R T+ +L E EY+F
Sbjct: 23350 TSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTR--STFKFTRLTEGNEYVF 23407
Query: 1740 RVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
RV A N G L+SE I ++++ +P + + + +TW+P E +GGS +
Sbjct: 23408 RVAATNRFGIGSYLQSEVIECRSSIRIPG-PPETLQIFDVSRDGMTLTWYPPEDDGGSQV 23466
Query: 1800 IDYKVEIKQ-EGKKWKXXXXXXXXXARIQK--LSINTTYQFRIYARNEIGTSLPYTSDDK 1856
Y VE K+ +W R + L+ Y+ R+ A N G+ P
Sbjct: 23467 TGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKP 23526
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
I + PP +P+N V+++T SV+L W+ PE GGS +T Y+IE + V WTK
Sbjct: 23527 IVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCN 23586
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
T + E+ + ++ + E FR+ A N G P E
Sbjct: 23587 TTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAE 23623
Score = 248 bits (606), Expect = 2e-64
Identities = 190/706 (26%), Positives = 301/706 (42%), Gaps = 43/706 (6%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK---HTKPS-----IDSKSASLTIKKVE 1351
K GS + + + P P W + K K K H P S+ + I + +
Sbjct: 9326 KAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECK 9385
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+ G Y + +N G V ++D P PP + +I S + W P++ G
Sbjct: 9386 RSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDR 9445
Query: 1412 IIYYVVEYQEIDTTEWISVK-NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE- 1469
I YV+E + ID W V + T + +L + Y FR A N I ET +
Sbjct: 9446 IKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQR 9505
Query: 1470 ------YYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
Y K++ + K +++ +P ++ + + + + + W G K +
Sbjct: 9506 TTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVEC-LAWDPTGTKKE 9564
Query: 1524 TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ--QKPVITISNE 1578
+ + ++ A N G + S VG Q+P + S
Sbjct: 9565 AWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSI- 9623
Query: 1579 DIKQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE-------YNITTKEKTSV 1629
D+K+ +V G + A I+G+P P + W+K K ++KE N + T
Sbjct: 9624 DLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCT 9683
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKP 1689
+ I + +RS + YTI A N GT+S E+ L V +P P GP+ +S + +T+ W P
Sbjct: 9684 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWFP 9743
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGF 1749
P DDGG ++T Y IEK E + W+ V+ ++ TY I KL E EY+FR++AQN G
Sbjct: 9744 PKDDGGSKITNYVIEKREANRKTWVHVSSEPKEC-TYTIPKLLEGHEYVFRIMAQNKYGI 9802
Query: 1750 SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ- 1808
E L+SEP + VP + S+ + W E +GGSP+ Y +E+K
Sbjct: 9803 GEPLDSEPETARNLFSVPG-APDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDT 9861
Query: 1809 EGKKWK------XXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKT 1862
K+WK ++ L + YQFR+YA N G D T
Sbjct: 9862 TSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDP 9921
Query: 1863 LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
+ PP P V++ T S L+W+ P +GGS +T YI+E+K + W K
Sbjct: 9922 IAPPGPPFP-KVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRG 9980
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
+ + +KE FR+SA N G+ P E V +E + SP
Sbjct: 9981 TKLVVTGLKEGAFYKFRVSAVNIAGIGEPGEVTDV-IEMKDRLVSP 10025
Score = 247 bits (605), Expect = 3e-64
Identities = 188/685 (27%), Positives = 304/685 (44%), Gaps = 31/685 (4%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKII-KKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
K G DV +L+ ++ P P W + K + +++ + DS S LTI +V D G Y
Sbjct: 20787 KAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSL-LTIPQVTRNDTGKY 20845
Query: 1359 KLRLENNCGHADVE-MNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
L +EN G ++V +LD P+ K + + ++ + WD P G S II YV+
Sbjct: 20846 ILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVI 20905
Query: 1418 EYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
E ++ W V + + T + +L + + FR A NE+ I + ETTE +K
Sbjct: 20906 EKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTE---PVKA 20962
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTC--IFGGVPQPKVTWYRDGKKLKT-AKATYENRX 1533
++ +P + +K+ +T+ + + T GG + R GK +T + A
Sbjct: 20963 AEVPAPIRDLSMKD-STKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTC 21021
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQ------KHKVG 1587
++ A N+ G + + I K +I D+ ++G
Sbjct: 21022 EIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIG 21081
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
+ +G P P + W K+G L+ + + E + IK K+ H KYT+
Sbjct: 21082 HNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVIL 21141
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
N +V +T+ PSKP+GP+ EI +SV + W P D+GG E+T Y+IEK E
Sbjct: 21142 DNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRE 21201
Query: 1708 PDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV 1766
W V + V R T+ + L ++ EY FRV A+N G S+ L S IV K +
Sbjct: 21202 TSQTNWKMVCSSVAR--TTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRI 21259
Query: 1767 PSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXX--XXXX 1823
P + ++ + +TW +GGS + + VE K+ W+
Sbjct: 21260 PG-PPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGRE 21318
Query: 1824 ARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG-KTLTPPSQPRNFVVSESTSRSV 1882
R L YQFR+YA N G S P + K T+ + PP P +++ + T ++
Sbjct: 21319 YRATGLVEGLDYQFRVYAENSAGLSSP-SDPSKFTLAVSPVDPPGTP-DYI--DVTRETI 21374
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TLKW P +GGS I Y IE K + W + S ++ + + D FRI A
Sbjct: 21375 TLKWNPPLRDGGSKIVGYSIE-KRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIA 21433
Query: 1943 ENTVG-VSLPTESQSVRLEKHATVP 1966
N VG +S P++S + + + VP
Sbjct: 21434 RNAVGTISPPSQSSGIIMTRDENVP 21458
Score = 246 bits (601), Expect = 9e-64
Identities = 188/708 (26%), Positives = 303/708 (42%), Gaps = 35/708 (4%)
Query: 1287 PPKI---VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
PP+I D + ++ + + L V + P+P +W I+ + + S
Sbjct: 18607 PPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTD--RAQIEVTSSFT 18664
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDE 1403
L I V D+G Y L LENN G +NV +LD PS P I E+ S+ + W+
Sbjct: 18665 MLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEP 18724
Query: 1404 PENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
P G + I Y+VE +E + ++ N TKT I+NL+ SY FR A NE I
Sbjct: 18725 PLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIG 18784
Query: 1463 DASETTEYYKV----IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
+ETTE KV + ++ V + I E E + I G V + + +
Sbjct: 18785 LPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQT---KG 18841
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC----VVG--IQQKPV 1572
+K T T ++ A N+ G + V+ I+ KP
Sbjct: 18842 SEKWSTC--TQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPS 18899
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + K + ++ + +G P V W K+G L+ N+++ + + + I
Sbjct: 18900 VELPFHTFNVKAR--EQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSI 18957
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLD 1692
KE + Y + SN+AG+ +V +T+ V D+P P GP+ + E+S +S+TI W PP
Sbjct: 18958 KEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPP-GPIRIDEVSCDSITISWNPPEY 19016
Query: 1693 DGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
DGG +++ Y +EK E + W V+ + I +L EY FRV A+N G S
Sbjct: 19017 DGGCQISNYIVEKKETTSTTWHIVSQAVART-SIKIVRLTTGSEYQFRVCAENRYGKSSY 19075
Query: 1753 LESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK- 1811
ES +V + P ++ +TW +GGS +I Y +E K+
Sbjct: 19076 SESSAVVAEYPFSPPGPPGTPKVVHA-TKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSI 19134
Query: 1812 KWKXX--XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQP 1869
W ++ L Y++R+YA N G S + + PP QP
Sbjct: 19135 LWSKANKILIADTQVKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQP 19194
Query: 1870 RNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIEN 1929
V+ T +SV+LKW++P +GG+ IT YI+E + + W K +
Sbjct: 19195 E---VTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTE 19251
Query: 1930 IKEKDEIIFRISAENTV-GVSLPTESQSVRLEKHATVPSPPTAPLEIR 1976
+ E FR+ A N VS P+ES + K PP ++++
Sbjct: 19252 LTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDV--EPPRVMMDVK 19297
Score = 243 bits (594), Expect = 6e-63
Identities = 215/796 (27%), Positives = 348/796 (43%), Gaps = 54/796 (6%)
Query: 1195 SINFTLRLPEFILVPANTDAYLTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKR 1251
+I +L+LP F L +EIP +++W K ++ T + +
Sbjct: 17812 TIQPSLKLP-FNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST 17870
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
L I++ +DD +YT ++ T L V V+E P V R S +++
Sbjct: 17871 VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVG---PVRFDEVSADFVVI 17927
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL---TIKKVENTDAGIYKLRL--EN 1364
++ P +++ I++K T + SA++ TIK + Y+ R+ EN
Sbjct: 17928 SWEP-PAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAEN 17986
Query: 1365 NCGH-ADVEMNVTILD----KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEY 1419
G A ++ I+ +P PPG P + I + + W EP N G + II Y +E
Sbjct: 17987 RYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQ 18046
Query: 1420 QEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKET 1477
+E ++ W+ + I T+ L Y F+ A N V I S+ +E + +
Sbjct: 18047 KEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF--VARD 18104
Query: 1478 KIQSPTVEKPLKNITTEPNEDIELT--CIFGGVPQPKVTWYRDGKKL----KTAKATYEN 1531
P +P + T N ++ GG K+T Y KK + KA++ N
Sbjct: 18105 PCDPPG--RPEAIVITRNNVTLKWKKPAYDGG---SKITGYIVEKKDLPDGRWMKASFTN 18159
Query: 1532 RXXXXXXXXXXXXXXXY--KCIAFNDHGEV-ETSCVVG-IQQKPVITISNEDIKQKHK-- 1585
Y + IA N G E S G I + I N + K+K
Sbjct: 18160 VLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDV 18219
Query: 1586 ----VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNI-TTKEKTSVIRIKELKRSH 1639
G+ +++ A I G P P+V+W K+G +LE I +T +KT+++ +K+ R+
Sbjct: 18220 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLV-VKDCIRTD 18278
Query: 1640 SSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELT 1699
+Y ++ SN GT S+ +T+KV D+P PEGP+ + ++ E + W PPL DGG ++
Sbjct: 18279 GGQYILKLSNVGGTKSIPITVKVLDRPGSPEGPLKVTGVTAEKCYLAWNPPLQDGGANIS 18338
Query: 1700 KYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV 1759
Y IEK E W +V+ + Y + KL EY+FRV+A N G E LES P+
Sbjct: 18339 HYIIEKRETSRLSWTQVS-TEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVT 18397
Query: 1760 IKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWK--XX 1816
P I +S+ +TW +GG+ I Y +E + +EG +W
Sbjct: 18398 ACNPYK-PPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNK 18456
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE 1876
R+ L+ +Y+FR+ A N G P L PP P N V++
Sbjct: 18457 KTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTD 18516
Query: 1877 STSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV-TVGGSVHEHCIENIKEKDE 1935
++ SV+L W++P +GG+P+ Y++E K WT G + + +KE E
Sbjct: 18517 TSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTE 18576
Query: 1936 IIFRISAENTVGVSLP 1951
FRI A N+ GV P
Sbjct: 18577 YNFRICAINSEGVGEP 18592
Score = 243 bits (594), Expect = 6e-63
Identities = 176/609 (28%), Positives = 276/609 (45%), Gaps = 30/609 (4%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
DKPS PG+ IL I S+ + W++PE G I+ Y VEY++ + W + + I
Sbjct: 23932 DKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDK 23991
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
Q +I L + Y FR +A NE +S T K K T ++P + K +K++TT+
Sbjct: 23992 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKT-KLTSGEAPGIRKEMKDVTTKLG 24050
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXXXXXXXXXXX-YKCIA 1552
E +L+C G P P + WYR GK+L + K + + R Y CIA
Sbjct: 24051 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 24110
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIKQKH--KVGDEWLVTAVIEGIPPPEVIWYKNG 1610
N+ GEVETS + +Q P +K+K+ VG + + G P P + W+
Sbjct: 24111 TNEVGEVETSSKLLLQATPQFH-PGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQ 24169
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKR-SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
L+N + I E + + +K ++R +H+ KY ++ SN GT + +++ DKP KP
Sbjct: 24170 KLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKP 24229
Query: 1670 EGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQ 1729
GP+++ + + S I WKPP DDGG +T Y +EK E ++ V T I
Sbjct: 24230 TGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIV 24289
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW 1788
L EN Y FRV AQN G S+ LE S ++IK+ + P + +S + W
Sbjct: 24290 NLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPG-APGKPTITAVTKDSCVVAW 24348
Query: 1789 FPSEKNGGSPIIDYKVEIKQEGK--KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNE 1844
P +GG+ I +Y +E K+E K KW ++ L Y+FR+ N
Sbjct: 24349 KPPASDGGAKIRNYYLE-KREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENL 24407
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQP------RNFVVSESTSRSVTLKWTEPESNGGSPIT 1898
G S + IT K+ P P RN V ++ ++ K T PI
Sbjct: 24408 GGESEWSEISEPIT-PKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVT----GHPKPIV 24462
Query: 1899 NYIIEFKTVKGKSWT-KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
+ + K + +I G H+ I ++ + D ++++ A N G T S V
Sbjct: 24463 KWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24522
Query: 1958 RLEKHATVP 1966
+ +P
Sbjct: 24523 EVPAKIHLP 24531
Score = 239 bits (586), Expect = 6e-62
Identities = 195/695 (28%), Positives = 293/695 (42%), Gaps = 36/695 (5%)
Query: 1280 KVEVVEFPPKI---VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
K E PP+I D + I+ + L V + P P +W + K
Sbjct: 15353 KAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPDPEVKWARDHGE----SLDKA 15408
Query: 1337 SIDSKSAS--LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
SI+S S+ L + V D+G Y L +EN+ G +NV +LD P PP + E+
Sbjct: 15409 SIESASSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTK 15468
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTSIQNLKTNSSYRFRA 1453
+S+ + WD P G S I Y+VE +E + +V N KT + L+ SY FR
Sbjct: 15469 TSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRV 15528
Query: 1454 YAVNEVDISDASETTEYYKVIKET----KIQSPTVEKPLKNITTEPNEDIELTCIFGGVP 1509
A NE I +ET E K + KI V + +++ E E + I G +
Sbjct: 15529 LAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIV 15588
Query: 1510 QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG--EVETSCVVGI 1567
+ + T K T ++ A N+ G + V I
Sbjct: 15589 EMQTKGSDKWATCATVKVT-----EATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVI 15643
Query: 1568 QQKPVITISNEDIKQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE 1625
+ VI + + + V G++ V G P P V W+K+ L+ N + E
Sbjct: 15644 AKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTE 15703
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
S++ IK+ R Y ++ +N+AG + + + V DKP P GPV M E++ +S+T+
Sbjct: 15704 NNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITL 15763
Query: 1686 EWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
W PP DGG + Y +EK + W I A V R C +L CEY FR+ A+
Sbjct: 15764 SWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKAC--RLKTGCEYQFRIAAE 15821
Query: 1745 NPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKV 1804
N G S L SEP V + VP +S+ + W +GGS +I Y +
Sbjct: 15822 NRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLS-SRDSMEVQWNEPISDGGSRVIGYHL 15880
Query: 1805 EIKQEGK-KWKXXXXXXXXXARIQK--LSINTTYQFRIYARNEIGTSLPYTSDDKITIGK 1861
E K+ W + + L Y+FR+ A N +G P +
Sbjct: 15881 ERKERNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARD 15940
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
PP +P +V T SVTL+W +P +GGS IT YI+E K + W K +
Sbjct: 15941 PCDPPGRPEAIIV---TRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMK-ASFTNI 15996
Query: 1922 VHEHC-IENIKEKDEIIFRISAENTVGV-SLPTES 1954
+ H + + E FR+ A N GV S P+ES
Sbjct: 15997 IDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSES 16031
Score = 238 bits (583), Expect = 1e-61
Identities = 199/754 (26%), Positives = 323/754 (42%), Gaps = 35/754 (4%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEF 1286
+TW K ++ T + + + TL I++ +DD +Y + + +E+V
Sbjct: 16764 ITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTL 16823
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL- 1345
K + + S ++ + + P + + I++K T D SA++
Sbjct: 16824 D-KPDPPKGPVKFDDVSAESITLSWNP-PLYTGGCQITNYIVQKRDTTTTVWDVVSATVA 16881
Query: 1346 -TIKKVENTDAGI-YKLRL--ENNCGHA-DVEMNVTILD----KPSPPGKPNILEIDSSS 1396
T KV G Y+ R+ EN G + +E + + +P PPG P I S
Sbjct: 16882 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDS 16941
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAY 1454
+ I W EP N G S +I Y +E +E ++ W V I TQ QNL+ Y FR Y
Sbjct: 16942 MVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVY 17001
Query: 1455 AVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG-VPQPKV 1513
A N V + AS+ +E Y + P +P+ E GG + +
Sbjct: 17002 AENIVGVGKASKNSECY--VARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYI 17059
Query: 1514 TWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHGEV-ETSCVVG-IQQ 1569
RD + KA++ N Y + IA N G + + S G I
Sbjct: 17060 VEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITA 17119
Query: 1570 KPVITISNEDIKQKHK------VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITT 1623
K + + + K + G+ + + A + G P P + W + ++E I
Sbjct: 17120 KDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKN 17179
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV 1683
+ +++ +K+ R +Y + ASN AG+ S V +KV D+P PEGPV + ++ E
Sbjct: 17180 TDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKC 17239
Query: 1684 TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
++ W PPL DGG +++ Y +EK E W VA + + + KL E EY+FR++A
Sbjct: 17240 SLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVAS-EVVTNSLKVTKLLEGNEYVFRIMA 17298
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G E LES P+++K +P I +S+ + W + +GGS II Y
Sbjct: 17299 VNKYGVGEPLESAPVLMKNPFVLPG-PPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 17357
Query: 1804 VEIK-QEGKKW--KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
VE + + G +W R+ L+ + Y+FR+ A N G P +
Sbjct: 17358 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKAC 17417
Query: 1861 KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT--V 1918
+ P P N + ++T S+TL W +P +GGS I Y++E + W +IVT
Sbjct: 17418 DPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEW-QIVTPQT 17476
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
G V I + E E R+ A N VG+ T
Sbjct: 17477 GLRVTRFEISKLTEHQEYKIRVCALNKVGLGEAT 17510
Score = 232 bits (568), Expect = 9e-60
Identities = 197/760 (25%), Positives = 319/760 (41%), Gaps = 45/760 (5%)
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
+ K R I + D CE T + K+ +L ++ ++++ + ++ G+ +
Sbjct: 21826 EYKFRVSAINGAGKGDSCEVTGTI---KAVDRLTAPELDID---ANFKQTHVVRAGASIR 21879
Query: 1307 LLVDYQAFPQPNDEWIV--NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLEN 1364
L + YQ P P W ++ ++ HT S ++LT++ DAG Y L +EN
Sbjct: 21880 LFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSF----STLTVENCNRNDAGKYTLTVEN 21935
Query: 1365 NCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
N G + V +LD P PPG ++ S + WD P G + I +YVVE +E
Sbjct: 21936 NSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASR 21995
Query: 1425 TEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT 1483
W + + T+ + +L Y FR AVNE + E E + I T + P
Sbjct: 21996 RSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVG---EPYEMPEPIVAT--EQPA 22050
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA----KATYENRXXXXXXX 1539
+ L + T + + ++T Y + K + +A + +
Sbjct: 22051 PPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDLWVEAGHTKQLTFTVER 22110
Query: 1540 XXXXXXXXYKCIAFNDHG-----EVETSCVVGIQQ-KPVIT---ISNEDIKQKHKVGDEW 1590
++ A ND G E +S ++ Q +P I+N+ I K G +
Sbjct: 22111 LVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCK--AGSPF 22168
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
+ I G P P+V W +L+ +ITT + + + +K+ R S +Y + NT
Sbjct: 22169 TIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 22228
Query: 1651 AGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN 1710
AG + VT+ V +P GP+ + +S ES + W P D GG E+T Y +EK E
Sbjct: 22229 AGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGT 22288
Query: 1711 NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
W V + + + L + EY FRV ++N G S+ LES PI+ + VP
Sbjct: 22289 TAWQLVNSSVKRTQIK-VTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPF-VPPSA 22346
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KW--KXXXXXXXXXARIQ 1827
+ ++ I W +GGS II Y VE K+ W + ++
Sbjct: 22347 PTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVT 22406
Query: 1828 KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWT 1887
L YQFR YA N G S + I + P +P V++ T +V+L W+
Sbjct: 22407 GLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPE---VTDVTRSTVSLIWS 22463
Query: 1888 EPESNGGSPITNYIIEFKTVK---GKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
P +GGS + YIIE K V W K S + + + E D FR+ A+N
Sbjct: 22464 APAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKN 22523
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVM 1984
GV + S+S +PP A L+ R+ G + +
Sbjct: 22524 AAGV-ISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTI 22562
Score = 232 bits (567), Expect = 1e-59
Identities = 185/693 (26%), Positives = 284/693 (40%), Gaps = 30/693 (4%)
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
+ R ++ G + + V + P P W ++ +K + + + L I +
Sbjct: 14284 ELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENT--ESFTLLIIPECN 14341
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
D G + + +EN G +NV +LD P P +I S+ + WD P G S
Sbjct: 14342 RYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSR 14401
Query: 1412 IIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
I Y+VE +E + + K + L Y FR A NE I + +ETTE
Sbjct: 14402 ITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTE- 14460
Query: 1471 YKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY-----RDGKKLKTA 1525
+K ++ SP + +IT G K+T Y R G T
Sbjct: 14461 --PVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDG--GSKITGYVIEAQRKGSDQWTH 14516
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV---ETSCVVGIQQKPVITISNEDIKQ 1582
T + ++ +A N G E+ V+ +Q + + I Q
Sbjct: 14517 ITTVKG-LECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQ 14575
Query: 1583 K---HKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSH 1639
K K GD V + G P P V W K L+ + N T ++++ I E RS
Sbjct: 14576 KLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSD 14635
Query: 1640 SSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELT 1699
S Y + A N G +T++V+D P P GP+ E+S + VT W PP +DGG+ ++
Sbjct: 14636 SGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPIS 14695
Query: 1700 KYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
Y +E + D+ W+++A V R TY +L EY FRV AQN G + S I
Sbjct: 14696 NYVVEMRQTDSTTWVELATTVIR--TTYKATRLTTGLEYQFRVKAQNRYGVGPGITSAWI 14753
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXX 1817
V VP + +S+ I+W +GGSPI+ Y VE K+ G W+
Sbjct: 14754 VANYPFKVPG-PPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVS 14812
Query: 1818 XXX--XXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVS 1875
+ L+ Y+FR+ A N G S P + + + PP +P V
Sbjct: 14813 KALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKP---VPL 14869
Query: 1876 ESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
T +VTLKW +PE GG IT+YI+E + + W K +E + + E
Sbjct: 14870 NITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAA 14929
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
FR+ A+N G P S + V +P
Sbjct: 14930 YEFRVIAKNAAGAISPPSEPSDAITCRDDVEAP 14962
Score = 232 bits (567), Expect = 1e-59
Identities = 208/857 (24%), Positives = 350/857 (40%), Gaps = 45/857 (5%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVV 1284
VTW+K IE + + + +L +R T D + YT +A + K +KV+V
Sbjct: 21493 VTWFKDGVEIEKRMNMEITNVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQ 21552
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
+ P K+V R I G +TL D P +I+ + + ++
Sbjct: 21553 DTPGKVVGPIRFTNIT-GEKMTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEA 21611
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCG-----HADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
S T K+ N + +++ N G +D + P PG P I +SI
Sbjct: 21612 QSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSI 21671
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKTQTSIQNLKTNSSYRFRAY 1454
+ W PE+ G S I Y++E +E +T W+ V + I++T+ + L + Y F
Sbjct: 21672 TLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVM 21731
Query: 1455 AVNEVDISDASETTEYYKVIKETKIQSP-TVEKPLKNITTEPNEDIELTCIFGGVP---- 1509
A N + AS + K + P TV K T + + GG+
Sbjct: 21732 AENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGY 21791
Query: 1510 --QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVG- 1566
+ T D K+ A+A + R ++ A N G+ ++ V G
Sbjct: 21792 IIEMCKTDLGDWHKVN-AEACVKTRYTVTDLQAGEEYK--FRVSAINGAGKGDSCEVTGT 21848
Query: 1567 IQQKPVITISNEDI----KQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
I+ +T DI KQ H V G + +G P P +W K + L +
Sbjct: 21849 IKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLS--LRAD 21906
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
I T + S + ++ R+ + KYT+ N +G+ S+ T+KV D P P GP+ ++++R
Sbjct: 21907 IHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPP-GPITFKDVTR 21965
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S T+ W PL DGG + Y +EK E W +V + + + L E Y FR
Sbjct: 21966 GSATLMWDAPLLDGGARIHHYVVEKREASRRSW-QVISEKCTRQIFKVNDLAEGVPYYFR 22024
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
V A N G E E ++ T P S + W + +GGS I
Sbjct: 22025 VSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDT---SKSSAVLAWLKPDHDGGSRIT 22081
Query: 1801 DYKVEIKQEGKK-WKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
Y +E++Q+G W +++L T Y+FR+ A+N+ G S P + + I
Sbjct: 22082 GYLLEMRQKGSDLWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVII 22141
Query: 1860 GKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTV 1918
+ P+ + ++ + +T G P + + ++ K ++ +T
Sbjct: 22142 KEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITT 22201
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMV 1978
+++ D + ++ ENT GV T S +V + P P T P+E+ V
Sbjct: 22202 TKDRTTLTVKDSMRGDSGRYFLTLENTAGVK--TFSVTVVVIGR---PGPVTGPIEVSSV 22256
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
+ + SWG P+ GG + Y + R+ T W V V + + L++ Y
Sbjct: 22257 SAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNS-SVKRTQIKVTHLTKYMEYS 22315
Query: 2039 IRIYARNEIGLSEPLES 2055
R+ + N G+S+PLES
Sbjct: 22316 FRVSSENRFGVSKPLES 22332
Score = 231 bits (564), Expect = 3e-59
Identities = 170/673 (25%), Positives = 288/673 (42%), Gaps = 33/673 (4%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
++ G + + ++ P P W + ++ L+I + DAG Y
Sbjct: 17539 VRAGGSARIHIPFKGRPMPEITWSREEGEFTDKVQIEKGVNY--TQLSIDNCDRNDAGKY 17596
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE 1418
L+LEN+ G + V +LD P PP + E+ S + W+ P G + + YV++
Sbjct: 17597 ILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVID 17656
Query: 1419 YQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKET 1477
+E + +V + +KT ++NL + Y FR A NE + ET + K +
Sbjct: 17657 KRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPP 17716
Query: 1478 ----KIQSPTVEKPLKNITTEPNEDIELTCIFGGVP--QPKVTWYRDGKKLKTAKATYEN 1531
K+ V + ++ E E + + G V QPK T K A++ N
Sbjct: 17717 SPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGT----EKWSIVAESKVCN 17772
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-----KV 1586
++ A+N+ G+ + V+G+ +K +
Sbjct: 17773 ---AVVTGLSSGQEYQFRVKAYNEKGKSDPR-VLGVPVIAKDLTIQPSLKLPFNTYSIQA 17828
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G++ + + G P P + W K+G L+ N+ ++V+ IKE + KYT+
Sbjct: 17829 GEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVT 17888
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKH 1706
A+N+AGT++ +++ V +KP P GPV E+S + V I W+PP GG +++ Y +EK
Sbjct: 17889 ATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKR 17948
Query: 1707 EPDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALD 1765
+ W V A V R T I KL EY FR+ A+N G S L+S+ ++++
Sbjct: 17949 DTTTTTWHMVSATVAR--TTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFK 18006
Query: 1766 VPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXA 1824
P I + + + W +GG+ II Y +E K++ W
Sbjct: 18007 EPG-PPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDT 18065
Query: 1825 RIQKLSIN--TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSV 1882
+ + ++ Y+F++ A N +G P + PP +P V+ T +V
Sbjct: 18066 KFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVI---TRNNV 18122
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TLKW +P +GGS IT YI+E K + W K E + + E FR+ A
Sbjct: 18123 TLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIA 18182
Query: 1943 ENTVG-VSLPTES 1954
N G S P++S
Sbjct: 18183 RNAAGNFSEPSDS 18195
Score = 230 bits (563), Expect = 4e-59
Identities = 211/770 (27%), Positives = 325/770 (42%), Gaps = 50/770 (6%)
Query: 1216 LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
L V++P T VTW+K ++ T + S L I+ +D Y L +
Sbjct: 15668 LKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTN 15727
Query: 1273 A--KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+ ++ L V V++ P + + S +TL P+ + +N+ I++K
Sbjct: 15728 SAGEAIETLNVIVLDKPGPPTGPVKMDEVTADS-ITLS---WGPPKYDGGSSINNYIVEK 15783
Query: 1331 ---CKHTKPSIDSKSASLTIKKVENTDAGIYKLRL--ENNCGHAD-VEMNVTILDKP--- 1381
T + + A TIK Y+ R+ EN G + + T+ P
Sbjct: 15784 RDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKV 15843
Query: 1382 -SPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQT 1438
PPG P + S+ + W+EP + G S +I Y +E +E ++ W+ + I +T+
Sbjct: 15844 PGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKF 15903
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
L+ Y FR A N V I S+ +E Y + P +P I T +
Sbjct: 15904 KTTGLEEGVEYEFRVSAENIVGIGKPSKVSECY--VARDPCDPPG--RPEAIIVTRNSVT 15959
Query: 1499 IELT--CIFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXY--KC 1550
++ GG K+T Y KK + KA++ N Y +
Sbjct: 15960 LQWKKPTYDGG---SKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRV 16016
Query: 1551 IAFNDHGEV-ETSCVVG-IQQKPVITISNEDIKQKHK------VGDEWLVTAVIEGIPPP 1602
IA N G E S G I + + + K+K G+ + V A I G P P
Sbjct: 16017 IARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIP 16076
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ W K +L N I + + + + +K+ R S Y ++A N AG SV V +KV
Sbjct: 16077 TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKV 16136
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
D+P PEGPV++ ++ E T+ WKPPL DGG ++ Y +E+ E W V D +
Sbjct: 16137 LDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVW-TVVDANVQ 16195
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+ + KL E EY FR++A N G E LESEP+V K VP + +
Sbjct: 16196 TLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPD-APKAPEVTTVTKD 16254
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXARIQKLSI--NTTYQFRI 1839
S+ + W +GGS I+ Y +E + +EG +W R++ + N Y+FR+
Sbjct: 16255 SMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRV 16314
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N G S P + P P N V + T SV L W++P +GG I
Sbjct: 16315 SAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQG 16374
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHC-IENIKEKDEIIFRISAENTVGV 1948
YI+E V WT G + +E + EK E FRI A N GV
Sbjct: 16375 YIVEKCDVNVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGV 16424
Score = 226 bits (553), Expect = 6e-58
Identities = 206/781 (26%), Positives = 325/781 (41%), Gaps = 48/781 (6%)
Query: 1207 LVPANTDAYLTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
LV A + VEIP VTW K +++ T++ + L I +C D
Sbjct: 14577 LVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDS 14636
Query: 1264 CEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
Y L A++ +V+ + IK + V + P ND +
Sbjct: 14637 GPYP---LTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVP 14693
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIK---KVENTDAGI---YKLRLENNCGHADVEMNVTI 1377
S + + + T + + A+ I+ K G+ ++++ +N G + I
Sbjct: 14694 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSAWI 14753
Query: 1378 LDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN 1432
+ P PPG P + + S+ I W EP + G S I+ Y VE +E + W +V
Sbjct: 14754 VANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSK 14813
Query: 1433 ITKTQTSIQN--LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN 1490
++ L +Y FR A N S S+ +E ++ I P PL N
Sbjct: 14814 ALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSE--PMLALDPIDPPGKPVPL-N 14870
Query: 1491 ITTEP-NEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXXXXXXXXXXXXX 1545
IT GG K+T Y RD + KA + N
Sbjct: 14871 ITRHTVTLKWAKPEYTGGF---KITSYIVEKRDLPNGRWLKANFSNILENEFTVSGLTED 14927
Query: 1546 XXY--KCIAFNDHGEV----ETSCVVGIQQKPVITISNEDIKQKH----KVGDEWLVTAV 1595
Y + IA N G + E S + + D+K K K G+ + + A
Sbjct: 14928 AAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEAD 14987
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ G PPP + W K+G +LE + I + ++ + K+ R S YT+ A+N G +
Sbjct: 14988 VSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAK 15047
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
+KV D+P PEGP+ + E++ E + W PPLDDGG ++ Y ++K E W
Sbjct: 15048 HIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTN 15107
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXX 1775
VA + V + KL + EY+FRV+A N G E LESEP++ P
Sbjct: 15108 VAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYG-PPDPPKNPE 15165
Query: 1776 XXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQE-GKKWKXXXXXXXXXAR--IQKLSIN 1832
I +S+ + W + +GGS II+Y VE + + G++W R + L+
Sbjct: 15166 VTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEG 15225
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESN 1892
Y+FRI A N G S P + T+ P P N V +++ S+++ W +P +
Sbjct: 15226 HEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYD 15285
Query: 1893 GGSPITNYIIEFKTVKGKSWTKIVT--VGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
GGS IT Y++E + W +IVT G + I + E E RI A N+ G+
Sbjct: 15286 GGSEITGYMVEIALPEEDEW-QIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE 15344
Query: 1951 P 1951
P
Sbjct: 15345 P 15345
Score = 225 bits (551), Expect = 1e-57
Identities = 240/963 (24%), Positives = 395/963 (41%), Gaps = 77/963 (7%)
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL 1200
+D E+QF+ ++ ++G + + ++ + + S VG C + P + ++
Sbjct: 9572 RDVEELQFT--VEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDC------QRPDMPPSI 9623
Query: 1201 RLPEFILVPANTDAYLTVEIPDETLD-VTWYK--------KKSVIEDTEKFTLISDVKKR 1251
L EF+ V T+ + +I +TW+K K+ V+ DT L+ D
Sbjct: 9624 DLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD-DTC 9682
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
TL+I + D YT ++ T ++++ V+ P V ++ +TL
Sbjct: 9683 TLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVG-PIKFESVSADQMTL-- 9739
Query: 1310 DYQAFPQPND--EWIVNSKIIKKCKHTKP----SIDSKSASLTIKKVENTDAGIYKLRLE 1363
FP +D I N I K+ + K S + K + TI K+ ++++ +
Sbjct: 9740 --SWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQ 9797
Query: 1364 NNCG-----HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE 1418
N G ++ E + P P KP + + +S+ + W+EPE G S + Y +E
Sbjct: 9798 NKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLE 9857
Query: 1419 YQEIDTTEWISV-KNITKTQT-----SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
++ + W V ++ K T + L S Y+FR YA+N + AS ++
Sbjct: 9858 MKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSD--P 9915
Query: 1473 VIKETKIQSPTVEKPLKNITTEPNEDIELTCIF---GGVPQPKVTWYRDGKKLKTAKATY 1529
I P P T+ + D+E + G + Y++ K + K
Sbjct: 9916 ATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKD 9975
Query: 1530 ENRXXXXXXXXXXXXXXXYK----CIAFNDHGEV-ETSCVVGIQQKPVITISNEDIKQKH 1584
+ YK + GE E + V+ ++ + V D +
Sbjct: 9976 KEVRGTKLVVTGLKEGAFYKFRVSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRD 10035
Query: 1585 KV----GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHS 1640
++ G + A + G PPP V W N L +E I T +S + IK +RSH
Sbjct: 10036 RIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLP--QEATIETTAISSSMVIKNCQRSHQ 10093
Query: 1641 SKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTK 1700
Y++ A N AG + + V D P P + ++ ES + W P DDGG +T
Sbjct: 10094 GVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITN 10153
Query: 1701 YAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPI 1758
Y IEK E D W V V R T +Q L + Y FR+ A+N +G +E SE +
Sbjct: 10154 YVIEKRESDRRAWTPVTYTVTRQNAT--VQGLIQGKAYFFRIAAENSIGMGPFVETSEAL 10211
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXX 1818
VI+ + VP N +V +TW P + +GGS II+Y +E + G +
Sbjct: 10212 VIREPITVPERPEDLEVKEVTKN-TVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVT 10270
Query: 1819 XXXXXAR---IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVS 1875
+R ++ L TY++R+ A N +G P IT L PP+ +F
Sbjct: 10271 NDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDK 10330
Query: 1876 ESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEK-- 1933
+ T S P ++ + V T I T ++ +E IK K
Sbjct: 10331 LTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATL---ALEKIKAKRS 10387
Query: 1934 DEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
D + + EN+ G S Q V + H P PP P+ V + ++ SW P D
Sbjct: 10388 DSGKYCVVVENSTG-SRKGFCQ-VNVVDH---PGPPVGPVSFDEVTKDYMVISWKPPLDD 10442
Query: 1994 GGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
GG+ + Y I ++V K +WM V T + L E Y+ RI+A N G+S+PL
Sbjct: 10443 GGSKITNYIIEKKEVGKDVWMPVTSASAKT-TCKVSKLLEGKDYIFRIHAENLYGISDPL 10501
Query: 2054 ESD 2056
SD
Sbjct: 10502 VSD 10504
Score = 225 bits (551), Expect = 1e-57
Identities = 219/892 (24%), Positives = 364/892 (40%), Gaps = 44/892 (4%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKSVIEDTEKFTLISDVK 1249
VE P + ++ + I+V A + +I L V +W K IE+ + +IS
Sbjct: 19287 VEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDN 19346
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV--EVVEFP-PKIVDYEREYRIKRGSDVT 1306
L ++ C D +Y L + T + V +V++ P P E ++
Sbjct: 19347 HTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLS 19406
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
+ D + + T + + S + K+ + I+++ N
Sbjct: 19407 WGRPQEDGGADIDYYHRKKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKY 19466
Query: 1367 GHADVEMNVTI--LDK---PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
G + +V I LD PSPP I + S+ +CW PE+ G S I Y++E +E
Sbjct: 19467 GVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERRE 19526
Query: 1422 IDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
++ W+ V K + + L+ Y +R YA N +S SET+ + +
Sbjct: 19527 KNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFL 19586
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIF-GGVPQPKVTW-YR-----DGK-KLKTAKAT-YE 1530
SP + + + + +F GG P T Y+ D K +++ + T Y
Sbjct: 19587 PSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYT 19646
Query: 1531 NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDE 1589
K A + + +++P+ I +E K K G
Sbjct: 19647 ISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGAS 19706
Query: 1590 WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
+ +T G P P V+W K L + Y TT +TS + I+ R+ S KYT+ N
Sbjct: 19707 FTMTVPFRGRPVPNVLWSKPDTDLRT-RAYVDTTDSRTS-LTIENANRNDSGKYTLTIQN 19764
Query: 1650 TAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
+S+ + +KV D P P + ++++++ES + W P +DGG + Y IEK E
Sbjct: 19765 VLSAASLTLVVKVLDTPGPPTN-ITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREAS 19823
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
W+ V + + +Y + L E Y FRV +N G E++ V T P
Sbjct: 19824 KKAWVSVTNNCNRL-SYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPE 19882
Query: 1770 XXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQK 1828
I +SV +TW E +GGS I+ Y VE ++G+K W +
Sbjct: 19883 KLGVTS---ISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSG 19939
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS-QPRNFVVSESTSRS-VTLKW 1886
L N+ Y FR++A N+ G S P + I + L PP +NF R+ LK
Sbjct: 19940 LRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKV 19999
Query: 1887 TEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEK---DEIIFRISAE 1943
P S G P+ + V K+ + T E+ N+KE D + I+A
Sbjct: 20000 DIPIS--GKPLPKVTLSRDGVPLKATMRFNT--EITAENLTINLKESVTADAGRYEITAA 20055
Query: 1944 NTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI 2003
N+ G + V L++ P PPT P+ I + V W P++DGG+ + Y +
Sbjct: 20056 NSSGTT-KAFINIVVLDR----PGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYIL 20110
Query: 2004 AIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
R+ + +W EV T+ + L+ Y RI A N G+S+ ++S
Sbjct: 20111 LKRETSTAVWTEVSATVARTM-MKVMKLTTGEEYQFRIKAENRFGISDHIDS 20161
Score = 223 bits (545), Expect = 5e-57
Identities = 196/806 (24%), Positives = 352/806 (43%), Gaps = 54/806 (6%)
Query: 1191 VEEPSINFTLRLPEFI--LVPANTDAYLTVEIPDE---TLDVTWYKKKSVIEDTEKFTLI 1245
++EP I T L L+ + T+++P VTW ++ +++T++ ++
Sbjct: 22141 IKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSIT 22200
Query: 1246 SDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYEREYRIKRGSD 1304
+ + TL ++ D Y L + V VV P V E + S
Sbjct: 22201 TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIE--VSSVSA 22258
Query: 1305 VTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP--SIDSKSASLTIKKVENTDAGIYKLRL 1362
+ ++ + I N + K+ T ++S IK T Y R+
Sbjct: 22259 ESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRV 22318
Query: 1363 --ENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
EN G + + I+ + PS P +P + + +++++I W+EP + G S II Y
Sbjct: 22319 SSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGY 22378
Query: 1416 VVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
VE +E +T W+ + + + + L Y+FR YA+N +S ASE + +
Sbjct: 22379 WVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASR--PI 22436
Query: 1474 IKETKIQSP-------TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK 1526
+ + + +P + I + P D + + + V+ DG+ LK
Sbjct: 22437 MAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLK-CN 22495
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV----ETSCVVGIQQKPVITISNEDIKQ 1582
T + ++ +A N G + E++ V + + + D +
Sbjct: 22496 YTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARL 22555
Query: 1583 KH-----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKR 1637
+ G + ++ A + G P P++IW K +L+ ++ ++ K + IK R
Sbjct: 22556 HGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDR 22615
Query: 1638 SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLE 1697
S S KYT+ N +GT +V V +KV D P P G + + +++E T+ W P +DGG E
Sbjct: 22616 SDSGKYTLTVKNASGTKAVSVMVKVLDSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAE 22674
Query: 1698 LTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEP 1757
+T Y +E+ E W+ + + + +Y + +L +N EY+FRV A N G +ESEP
Sbjct: 22675 ITHYIVERRETSRLNWV-IVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEP 22733
Query: 1758 IVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKW--- 1813
IV + + +PS E + I W E +GG+ I +Y V+ ++ E +W
Sbjct: 22734 IVARNSFTIPSPPGIPEEVGT-GKEHIIIQWTKPESDGGNEISNYLVDKREKESLRWTRV 22792
Query: 1814 KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK---TLTPPSQPR 1870
++ L YQFR+ A N G S P + I+ + T PPS PR
Sbjct: 22793 NKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSERSNFISCREPSYTPGPPSAPR 22852
Query: 1871 NFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVH--EHCIE 1928
V ++T S++L WT+P +GG+ I Y++E + W ++ T ++ E +
Sbjct: 22853 ---VVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHT-NATIRNTEFTVP 22908
Query: 1929 NIKEKDEIIFRISAENTVGVSLPTES 1954
++K + FR++A N G+S +ES
Sbjct: 22909 DLKMGQKYSFRVAAVNVKGMSEYSES 22934
Score = 223 bits (544), Expect = 7e-57
Identities = 207/895 (23%), Positives = 362/895 (40%), Gaps = 51/895 (5%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKSVIEDTEKFTLISDVKKRT 1252
P+I+ + + I VPA L + I +W+ S + ++E+ T+ + K
Sbjct: 23239 PTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAK 23298
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQ 1312
L IR+ T D EYT L + TT ++V+ K +I ++ + ++
Sbjct: 23299 LTIRETTIRDTGEYTLELKNVTGTTSETIKVIILD-KPGPPTGPIKIDEIDATSITISWE 23357
Query: 1313 AFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT---IKKVENTDAGIYKLRLE--NNCG 1367
P+ + ++ ++++ +P S S+T K T+ Y R+ N G
Sbjct: 23358 P-PELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFG 23416
Query: 1368 HADVEMNVTI-----LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI 1422
+ I + P PP I ++ + + W PE+ G S + Y+VE +E+
Sbjct: 23417 IGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEV 23476
Query: 1423 DTTEWISVKNITKTQTSIQN--LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ 1480
W+ V + T T ++ L Y R A+N S ++ ++ I
Sbjct: 23477 RADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSK--PIVAMDPIA 23534
Query: 1481 SP-TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR------DGKKLKTAKATYENRX 1533
P + P TT + + + + KVT Y D + T
Sbjct: 23535 PPGKPQNPRVTDTTRTSVSLAWS-VPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIR 23593
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVG-IQQKPVITISNEDIKQKH------KV 1586
++ +A N G E + V G ++ ++ + ++ +++ +
Sbjct: 23594 EYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQ 23653
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G +T I+G P P W K G + K I T E + + IKE R S Y +
Sbjct: 23654 GGVIRLTIPIKGKPFPICKWTKEGQDIS--KRAMIATSETHTELVIKEADRGDSGTYDLV 23711
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKH 1706
N G +V + ++V P+ PEGP+ +I SV + W+PP DDGG ++ Y +E+
Sbjct: 23712 LENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERR 23771
Query: 1707 EPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTALD 1765
E W + R + ++ L EN EY FRV A+N G S+ L+S EP+ KT L+
Sbjct: 23772 EVPKAAWYTIDSRVRGT-SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLN 23830
Query: 1766 VPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXX 1822
P + SV ++W + +GGS + Y +E K+
Sbjct: 23831 PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKVVRHNKTQITTT 23890
Query: 1823 XARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSV 1882
+ L + YQFRI A+N++G S + + + PSQP + + SV
Sbjct: 23891 MYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSV 23950
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TL+W +PE +GG I Y +E++ +W K + I + E E FR+ A
Sbjct: 23951 TLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFA 24010
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
EN G+S P + ++ ++ T P E++ V + + G A L
Sbjct: 24011 ENETGLSRPRRT-AMSIKTKLTSGEAPGIRKEMKDVTTKL-----------GEAAQLSCQ 24058
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
I R + W GK + + K+ + HT + + + G+ + ++E
Sbjct: 24059 IVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNE 24113
Score = 221 bits (540), Expect = 2e-56
Identities = 185/703 (26%), Positives = 304/703 (43%), Gaps = 40/703 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV----KNITK 1435
KPSPP P ++ +S+++ W P + G S I+ Y+VEYQ++ EW ++ +
Sbjct: 10615 KPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESCPE 10674
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
T+ + L+ +Y+FR AVN SD + E V+ + +++ P + N+ E
Sbjct: 10675 TKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE--PVLVKDRLEPPELILDA-NMAREQ 10731
Query: 1496 N----EDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXXXXY 1548
+ + + L+ I GVP PKVTW ++ + T KA + Y
Sbjct: 10732 HIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPT-KARIDVTPVGSKLEIRNAAHEDGGIY 10790
Query: 1549 KCIAFNDHGEVETSCVVGIQQKPVITISNEDIK-QKHKVGDEWLVTAVIEGIPPPEVIWY 1607
N G S V + KP E + +K W G +
Sbjct: 10791 SLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVE 10850
Query: 1608 KNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT---LKVYD 1664
+ + T+K+K+ K L + + + A N G T +K D
Sbjct: 10851 RRDVASAQWSPLSATSKKKSHFA--KHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALD 10908
Query: 1665 KPSKPEGP---VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
P P GP + ++ + V++ W P DGG +T Y +E E WIK V
Sbjct: 10909 -PLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVT- 10966
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDN 1781
++E + L + Y FRV A+N VG + PI + L PS +
Sbjct: 10967 NLECV-VTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVV 11025
Query: 1782 ESVYITWFPSEKNGGS-PIIDYKV---EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQF 1837
++ FP+ G P + EIK + + + I+ T ++
Sbjct: 11026 KAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSVLTIKNCLRRDTGEY 11084
Query: 1838 RIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPI 1897
+I N G+ T +T+ PP+ P N + + T +T+ W P+ +GGSP+
Sbjct: 11085 QITVSNAAGSK---TVAVHLTVLDVPGPPTGPINIL--DVTPEHMTISWQPPKDDGGSPV 11139
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
NYI+E + + +W +V+ G S + I ++++ E +FR+ AEN +GV P +S
Sbjct: 11140 INYIVEKQDTRKDTWG-VVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPT 11198
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
+ + PSPP P+ + + N SW P+ DGG+P+ GY + R+VT W+ V
Sbjct: 11199 VAKHKFSPPSPPGKPV-VTDITENAATVSWTLPKSDGGSPITGYYMERREVTGK-WVRVN 11256
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
K + LKF + L E +TY R++A N GLS+P S +P K
Sbjct: 11257 KTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIK 11299
Score = 221 bits (540), Expect = 2e-56
Identities = 191/796 (23%), Positives = 336/796 (42%), Gaps = 44/796 (5%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSV-IEDTEKFTLISDVK 1249
+E P I+ + V A ++ + + I + L + V ++ T +F +
Sbjct: 19974 LEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAE 20033
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
T+ +++ D Y ++ TTK + +V + I ++ ++ +
Sbjct: 20034 NLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLD-RPGPPTGPVVISDITEESVTL 20092
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSID-SKSASLTIKKVENTDAGI---YKLRLENN 1365
++ + N ++K+ T + S + + T+ KV G ++++ EN
Sbjct: 20093 KWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENR 20152
Query: 1366 CGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
G +D + + K P PP P + + SI + W EP + G S ++ Y +E +
Sbjct: 20153 FGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMK 20212
Query: 1421 EIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK 1478
+ ++ W I T + + Y FR YA N + S +E V+
Sbjct: 20213 DRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSE--PVLAIDA 20270
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXX 1534
+ P + + + GG K+T Y RD + KA++ N
Sbjct: 20271 CEPPRNVRITDISKNSVSLSWQQPAFDGG---SKITGYIVERRDLPDGRWTKASFTNVTE 20327
Query: 1535 XXXXXXXXXXXXXYKCIAF--NDHGEVET-SCVVG------IQQKPVITISNEDIKQ-KH 1584
Y+ F N G + S VVG PVI + E + K+
Sbjct: 20328 TQFTISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKY 20387
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+ G + A I G P P + WYK+ +L+ + + + I IK+ R +S Y
Sbjct: 20388 RAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYE 20447
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
++ N ++S + +++ DKP P GP+ + ++ E +T+ W+PP DDGG ++T Y +E
Sbjct: 20448 LKLRNAMASASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVE 20507
Query: 1705 KHEPDNNRWIKVAD-VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTA 1763
K E W V++ ++ + T K+ + EY+FRV A N G E LES+ +V K A
Sbjct: 20508 KRETSRVVWSMVSEHLEECIIT--TTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNA 20565
Query: 1764 LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK--WKXXXXXXX 1821
P I S+ + W +GGS I Y +E K++ K W
Sbjct: 20566 FVTPG-PPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLE-KRDKKSLGWFKVLKETI 20623
Query: 1822 XXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKI-TIGKTLTPPSQPRNFVVSEST 1878
R + L+ N+ YQ+R+ A N G P++ + + PP P +++ST
Sbjct: 20624 RDTRQKVTGLTENSDYQYRVCAVNAAGQG-PFSEPSEFYKAADPIDPPGPPAKIRIADST 20682
Query: 1879 SRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG-SVHEHCIENIKEKDEII 1937
S+TL W++P +GGS +T Y++E + + + WT + T G E+ + N+K
Sbjct: 20683 KSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYY 20742
Query: 1938 FRISAENTVGVSLPTE 1953
FR+SA N G P E
Sbjct: 20743 FRVSAVNCAGQGEPIE 20758
Score = 220 bits (537), Expect = 5e-56
Identities = 207/803 (25%), Positives = 340/803 (42%), Gaps = 53/803 (6%)
Query: 1202 LPEFI-LVPANTDAYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
LP+ L N++ L + I + V+W K + + + ++ S TLI+ C
Sbjct: 13490 LPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQ 13549
Query: 1260 EDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
+ D +YT L + T + + + V P I ++ +TL A P+ +
Sbjct: 13550 KSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLK---WAPPKDD 13606
Query: 1319 DEWIVNSKIIKK--CKHTKPSIDSKSASLTIKKVENTDAGI---YKLRLENNCGHADVEM 1373
+ + I++K + K + + T +V G+ +++ EN G +
Sbjct: 13607 GGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLK 13666
Query: 1374 NVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWI 1428
+ I+ D P P PNI+++ S+++ W +P+ TG S I Y +E++E ++ W
Sbjct: 13667 SEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLW- 13725
Query: 1429 SVKNITKTQTSIQNLKTNS-----SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT 1483
K KT +++ K Y FR A+N + S +E V+ I P
Sbjct: 13726 --KRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSE--PVVALDPIDPPG 13781
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXXXXXXX 1539
+ + NIT I + G K+T Y RD KA + N
Sbjct: 13782 KPEVI-NITRNSVTLIWTEPKYDG--GHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTV 13838
Query: 1540 XXXXXXXXY--KCIAFNDHGEV-------ETSCVVGIQQKPVITISNEDIKQ--KHKVGD 1588
Y + A N G + ET + P I + + IK K GD
Sbjct: 13839 TDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVL-DPTIKDGLTIKAGD 13897
Query: 1589 EWLVTAV-IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
++ A+ I G P P+ W K G + IT+ +S++ IK R + +YTI A
Sbjct: 13898 TIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITA 13957
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
+N GT V + V D P P GPV + +S E T+ W PPL+DGG + Y +EK E
Sbjct: 13958 TNPFGTKVEHVKVTVLDVPGPP-GPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRE 14016
Query: 1708 PDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP 1767
W V++ D + KL + EY+FRV A N G E ++SEP+ + P
Sbjct: 14017 TSRLLWTVVSE-DIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPP 14075
Query: 1768 SXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXXXXXXXXAR- 1825
N + ++W +GGS I Y VE ++ + +W R
Sbjct: 14076 GPPEKPEVSNVTKNTAT-VSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRC 14134
Query: 1826 -IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTL 1884
+ L +TY+FR+ A N G P + D + + PP P N V+++T +S +L
Sbjct: 14135 KVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASL 14194
Query: 1885 KWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT-VGGSVHEHCIENIKEKDEIIFRISAE 1943
W +P +GG IT Y++E + V ++W K T + + + +++ K++ FRISA
Sbjct: 14195 AWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAI 14254
Query: 1944 NTVGVSLPTESQSVRLEKHATVP 1966
N GV P V + + P
Sbjct: 14255 NDAGVGEPAVIPDVEIVEREMAP 14277
Score = 218 bits (533), Expect = 2e-55
Identities = 213/861 (24%), Positives = 372/861 (43%), Gaps = 50/861 (5%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVV 1284
V+W+K ++ + + ++ + + L K D +Y V+ ++ + K +V VV
Sbjct: 10353 VSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVV 10412
Query: 1285 EFP-PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
+ P P + + K ++ +I+ K + K + S
Sbjct: 10413 DHPGPPVGPVSFDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKT 10472
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHAD--VEMNVTILDK---PSPPGKPNILEIDSSSIN 1398
+ + K+ I+++ EN G +D V ++ D+ P P +P + E+ S
Sbjct: 10473 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSAL 10532
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNIT---KTQTSIQNLKTNSSYRFRAYA 1455
+ W++P + G I Y++E +E + W V T+ + +L Y FR A
Sbjct: 10533 VTWNKPHD-GGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSA 10591
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI----FGG--VP 1509
NE+ I D S ++ V + I P+ + I T N ++LT GG +
Sbjct: 10592 ENEIGIGDPSPPSK--PVFAKDPIAKPSPPVNPEAIDTTCNS-VDLTWQPPRHDGGSKIL 10648
Query: 1510 QPKVTWYRDG-KKLKTAKATYENRXXXXXXXXXXXXXXXYK--CIAFNDHGEVETSCV-- 1564
V + + G ++ + A T E+ YK +A N GE + + V
Sbjct: 10649 GYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE 10708
Query: 1565 -VGIQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
V ++ + P + + +++H KVGD ++A+I+G+P P+V W K
Sbjct: 10709 PVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARI 10768
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREIS 1679
++T S + I+ Y++ N AG+ +V V + V DKP P + + EI
Sbjct: 10769 DVT--PVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPR-DLEVSEIR 10825
Query: 1680 RESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMF 1739
++S + WK PLDDGG +T Y +E+ + + +W ++ + +++ + LNE +Y+F
Sbjct: 10826 KDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKK-KSHFAKHLNEGNQYLF 10884
Query: 1740 RVIAQNPVGFSEALESEPIVIKTALDV--PSXXXXXXXXXXIDNESVYITWFPSEKNGGS 1797
RV A+N G +E+ P IK ALD P +D V + W +++GGS
Sbjct: 10885 RVAAENQYGRGPFVET-PKPIK-ALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGS 10942
Query: 1798 PIIDYKVEIKQEG-KKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDK 1856
PI Y VE ++EG + W + L TY+FR+ A N +G LP T+
Sbjct: 10943 PITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTT-IP 11001
Query: 1857 ITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTK 1914
I + L PPS + + E T+++ P + + +K
Sbjct: 11002 IECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYT 11061
Query: 1915 IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLE 1974
+ T S I+N +D ++I+ N G +++ +V L VP PPT P+
Sbjct: 11062 VETDNFS-SVLTIKNCLRRDTGEYQITVSNAAG----SKTVAVHLTV-LDVPGPPTGPIN 11115
Query: 1975 IRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSEN 2034
I V + SW P+ DGG+P++ Y + +D K W V T K I L +
Sbjct: 11116 ILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKT-KLKIPHLQKG 11174
Query: 2035 HTYMIRIYARNEIGLSEPLES 2055
Y+ R+ A N+IG+ PL+S
Sbjct: 11175 CEYVFRVRAENKIGVGPPLDS 11195
Score = 217 bits (531), Expect = 3e-55
Identities = 170/693 (24%), Positives = 291/693 (41%), Gaps = 26/693 (3%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP P +++ SI++ W +P G + I+ YV+E QE DT +W V I T+
Sbjct: 22845 PGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE 22904
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPN 1496
++ +LK Y FR AVN +S+ SE+ + ++ +I + LK +T
Sbjct: 22905 FTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAG 22964
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFN 1554
+ L G P P +TW + G L + T E+ Y A N
Sbjct: 22965 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAEN 23024
Query: 1555 DHGEVETSCVVGIQQKP--VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
G+ + +V + P ++ +++ + V W + + G P I K
Sbjct: 23025 QSGKKSATVLVKVYDTPGPCPSVKVKEVS-RDSVTITWEIPTIDGGAPINNYIVEKREAA 23083
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+ K +TTK ++ RI L + + N G T P P
Sbjct: 23084 MRAFK--TVTTKCSKTLYRISGLVEGTMHYFRVLPENIYGIGEPCETSDAVLVSEVPLVP 23141
Query: 1673 VIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQK 1730
+ ++++ +VT+ W+ PL DGG LT Y +E + RW+KV + V + +
Sbjct: 23142 AKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTS 23201
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV-PSXXXXXXXXXXIDNESVYITWF 1789
LNE +Y+FR+ AQN G SE E+ V L V P+ I +
Sbjct: 23202 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVEL 23261
Query: 1790 PSEKNGGSPIID---YKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
G P + +E ++ I++ +I T ++ + +N G
Sbjct: 23262 VIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTG 23321
Query: 1847 TSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT 1906
T+ + K+ I PP+ P + E + S+T+ W PE +GG+P++ Y++E +
Sbjct: 23322 TT---SETIKVIILDKPGPPTGP--IKIDEIDATSITISWEPPELDGGAPLSGYVVEQRD 23376
Query: 1907 VKGKSWTKIV-TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATV 1965
W + +V S + + E +E +FR++A N G+ +S+ + +
Sbjct: 23377 AHRPGWLPVSESVTRSTFK--FTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRI 23434
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP L+I V + + +W PE DGG+ + GY + ++V W+ V KV V +
Sbjct: 23435 PGPPET-LQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTR 23493
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ L+E Y R+ A N G +P +P
Sbjct: 23494 YRSTGLTEGLEYEHRVTAINARGSGKPSRPSKP 23526
Score = 217 bits (530), Expect = 4e-55
Identities = 236/1040 (22%), Positives = 413/1040 (39%), Gaps = 74/1040 (7%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
LPP+I+ Q + G K E + K +W K E+ S+H+ + L
Sbjct: 12401 LPPKILMPEQIT-IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSIL 12459
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAY-LTVEIP 1221
I D D+G YS NS T ++ ++ P F + + DA L+ IP
Sbjct: 12460 IIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIP 12519
Query: 1222 --DETLDVTWY-KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD----AK 1274
D ++T Y +K + + T ++ V K + + K + + + ++
Sbjct: 12520 LEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISE 12579
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
T K+ V +FP + + R+ + + + V + I+ I +K +++
Sbjct: 12580 PLTSPKM-VAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNS 12638
Query: 1335 KPSIDSKSASLTIKKVENTDAGI-----YKLRLE--NNCGHADVEMN---VTILDKPSPP 1384
+ K+ ++ E AG+ Y R+ N G + VT PP
Sbjct: 12639 LLWV--KANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPP 12696
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN----ITKTQTSI 1440
GKP ++++ S++++ W P++ G S II Y VE ++ +W+ I + + +
Sbjct: 12697 GKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTA 12756
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI-TTEPNEDI 1499
L+ + Y+FRA A V+IS SE ++ ++ E + +K++ T + ++
Sbjct: 12757 TGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNV 12816
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFND 1555
L G P P V+W +DG LK A+ A N Y A N
Sbjct: 12817 CLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENS 12876
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G + + + KP S +K D A++ PP E + N + +
Sbjct: 12877 SGSKSATIKLKVLDKPGPPAS---VKINKMYSDR----AMLSWEPPLEDGGSEITNYIVD 12929
Query: 1616 DKEYN------ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYD 1664
+E + ++ + +++L H ++ I A N G + + YD
Sbjct: 12930 KRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTEPAIAKNPYD 12989
Query: 1665 KPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE 1724
P + + PVI I+++ +T+ WKPP DDGG +T Y +EK E W KV
Sbjct: 12990 PPGRCDPPVISN-ITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIER 13048
Query: 1725 TYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
T L E EY FRV A N G + ++ P SV
Sbjct: 13049 TLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPAPPAFPKVYDTTRSSV 13108
Query: 1785 YITWFPSEKNGGSPIIDYKVEIKQ-EGKKW---KXXXXXXXXXARIQKLSINTTYQFRIY 1840
++W +GGSPII Y VE+K+ + W + L +T YQFR+Y
Sbjct: 13109 SLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVY 13168
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSEST--SRSVTLKWTEPESNGGSPIT 1898
A N+IG S P DK L PP + + ++ VT++ P P
Sbjct: 13169 AVNKIGYSDPSDVPDKHYPKDILIPPEGEHDADLRKTLILRAGVTMRLYVPVKGRPPPKI 13228
Query: 1899 NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
+ ++ + I + C EN+ + D + ++ EN+ G + +
Sbjct: 13229 TWSKPNVNLRDRIGLDIKSTDFDTFLRC-ENVNKYDAGKYILTLENSCG-----KKEYTI 13282
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
+ K P PP + ++ + + +W P DGG+P++ Y + RD + W V
Sbjct: 13283 VVKVLDTPGPPIN-VTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTV-T 13340
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTE 2078
+ + F + +L E +Y R++A NE G+ +P E+ + K A + PG +
Sbjct: 13341 TECSKTSFRVPNLEEGKSYFFRVFAENEYGIGDPGETRDAVK--------ASQTPGPVVD 13392
Query: 2079 VXXXXXXXXXXXXXWLREHN 2098
+ W + H+
Sbjct: 13393 LKVRSVSKSSCSIGWKKPHS 13412
Score = 215 bits (525), Expect = 1e-54
Identities = 135/442 (30%), Positives = 209/442 (47%), Gaps = 13/442 (2%)
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYDKPSKPEGPVIMREISR 1680
K + R+K L ++ + A N AG S+ + +K P P G ++++ +
Sbjct: 7441 KDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGK 7500
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
SV + W P DGG ++ Y IE + + W++VA+ + + + L E EY FR
Sbjct: 7501 TSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTTQ-HLLPGLMEGQEYSFR 7559
Query: 1741 VIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
V A N G SE E S+P++ + L PS N + + W EK+GGSPI
Sbjct: 7560 VRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKN-TADLKWTVPEKDGGSPI 7618
Query: 1800 IDYKVEIKQEGKK-WKXXXXXXXXX-ARIQKLSINTTYQFRIYARNEIGTSLPYTS-DDK 1856
+Y VE + +K W+ + L+ + Y FR+ A N IG S YT +D
Sbjct: 7619 TNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAENAIGQS-DYTEIEDS 7677
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
+ T T P P V + T R V LKW P+++GG PI Y+IE K G W K
Sbjct: 7678 VLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAG 7737
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIR 1976
G + ++ E E+ F++ AEN GV P+E + + T P P L +
Sbjct: 7738 KTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVT 7797
Query: 1977 MVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRD-LSENH 2035
G + +W PE +GG+P++GY++ + V WM V + LKF + + + +
Sbjct: 7798 DAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDK 7857
Query: 2036 TYMIRIYARNEIGLSEPLESDE 2057
Y++R+ A N IG+SEP E E
Sbjct: 7858 EYVLRVRAVNAIGVSEPSEISE 7879
Score = 215 bits (525), Expect = 1e-54
Identities = 213/871 (24%), Positives = 352/871 (40%), Gaps = 56/871 (6%)
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVE 1285
+W K I ++ + S L I+ T D EYT + T +KV V++
Sbjct: 13915 SWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD 13974
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
P E + +T + P +I+ + + T S D +S
Sbjct: 13975 VPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRH 14034
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEMN--VTILDK---PSPPGKPNILEIDSSSINIC 1400
K+ + I+++ N+ G + + V ++D+ P PP KP + + ++ +
Sbjct: 14035 VATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVS 14094
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI-SVKN-ITKTQTSIQNLKTNSSYRFRAYAVNE 1458
W P + G S I Y VE +E + W+ ++K ++ + + L+ S+Y FR A N
Sbjct: 14095 WKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENR 14154
Query: 1459 VDISDASETTEYYKVIKETKIQSP--------TVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
I SE ++ + P T +K +P+ D L V
Sbjct: 14155 AGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEH 14214
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV--VGIQ 1568
KV D +K T ++ A ND G E + + V I
Sbjct: 14215 QKVG---DEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIV 14271
Query: 1569 QKPVITISNEDIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
++ + D + + + G + I+G P PEV W K+ L+N NI
Sbjct: 14272 EREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKN--RANIENT 14329
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI-MR--EISRE 1681
E +++ I E R + K+ + N AG S V ++V D P GPV+ +R +I+++
Sbjct: 14330 ESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTP----GPVLNLRPTDITKD 14385
Query: 1682 SVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRV 1741
SVT+ W PL DGG +T Y +EK E + A TY + L+E CEY FRV
Sbjct: 14386 SVTLHWDLPLIDGGSRITNYIVEKREATRKSY-STATTKCHKCTYKVTGLSEGCEYFFRV 14444
Query: 1742 IAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
+A+N G E E+ EP+ A P I +V + W + +GGS I
Sbjct: 14445 MAENEYGIGEPTETTEPVKASEAPSPPDSLNIMD----ITKSTVSLAWPKPKHDGGSKIT 14500
Query: 1801 DYKVEIKQEGK-KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
Y +E +++G +W ++ L+ Y F++ A N G S P S I
Sbjct: 14501 GYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVK 14560
Query: 1860 GKTLTPPSQPRNFVVSESTSRSV-TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV 1918
+T+ P R +++ +K P P + + +K T
Sbjct: 14561 EQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETT 14620
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMV 1978
S + E ++ D + ++A N VG + ++ H +P PPT P++ V
Sbjct: 14621 ATSTILNINECVRS-DSGPYPLTARNIVG----EVGDVITIQVH-DIPGPPTGPIKFDEV 14674
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S+ V SW PE DGG P+ Y + +R T W+E+ + T + L+ Y
Sbjct: 14675 SSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVELATTVIRT-TYKATRLTTGLEYQ 14733
Query: 2039 IRIYARNEIGLSEPLES-----DEPFKVIPG 2064
R+ A+N G+ + S + PFKV PG
Sbjct: 14734 FRVKAQNRYGVGPGITSAWIVANYPFKV-PG 14763
Score = 213 bits (521), Expect = 4e-54
Identities = 206/899 (22%), Positives = 374/899 (41%), Gaps = 44/899 (4%)
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTL 1244
T I + P I+ L E + A T L I + + WYK ++ +
Sbjct: 20365 TCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCV 20424
Query: 1245 ISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRG 1302
+ +++I+ + Y L +A ++ ++V++++ P E++
Sbjct: 20425 ENTTDLASILIKDADRLNSGCYELKLRNAMASASATIRVQILDKPGP-PGGPIEFKTVTA 20483
Query: 1303 SDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKL 1360
+TLL A +IV + + + S + +T K+ + I+++
Sbjct: 20484 EKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRV 20543
Query: 1361 RLENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
R N G + + +++ K P PPG P + +I +S+ + W P G S I Y
Sbjct: 20544 RAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGY 20603
Query: 1416 VVEYQEIDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
+E ++ + W V + I T+ + L NS Y++R AVN SE +E+YK
Sbjct: 20604 FLEKRDKKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKA 20663
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIF--GGVPQPKVTWYRDGKKLK--TAKATY 1529
P + + + T ++ G V R G++ + T
Sbjct: 20664 ADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKG 20723
Query: 1530 ENRXXXXXXXXXXXXXXXY-KCIAFNDHGEVE-TSCVVGIQQKPVITISNEDIKQK---- 1583
E R Y + A N G+ E +Q K ++ D+
Sbjct: 20724 EVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTS 20783
Query: 1584 --HKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
K G++ V +G PPP V W K+ L +D Y+I + +S++ I ++ R+ +
Sbjct: 20784 VIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTG 20843
Query: 1642 KYTIEASNTAG-TSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTK 1700
KY + N G S V++KV D P+ + + ++ +SR +VT+ W PPL DGG +
Sbjct: 20844 KYILTIENGVGEPKSSTVSVKVLDTPAACQ-KLQVKHVSRGTVTLLWDPPLIDGGSPIIN 20902
Query: 1701 YAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIV 1759
Y IEK + W V ++ + L+E + FRV+A+N +G E E +EP+
Sbjct: 20903 YVIEKRDATKRTW-SVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPV- 20960
Query: 1760 IKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXX 1818
A +VP+ SV ++W + +GGS I +Y VE K +G++ W
Sbjct: 20961 --KAAEVPAPIRDLSMKDS-TKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGI 21017
Query: 1819 XXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSEST 1878
+ +L + +FR++A+NE G S P T +TP + ++ T
Sbjct: 21018 SKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVT 21077
Query: 1879 SR-SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEII 1937
R + P P +++ + +K + + + I+N K++
Sbjct: 21078 VRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKI-TLSIKNAKKEHGGK 21136
Query: 1938 FRISAENTV-GVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGA 1996
+ + +N V +++P ++ PS P P+ + ++ V+ SW PE +GG
Sbjct: 21137 YTVILDNAVCRIAVPITVITL------GPPSKPKGPIRFDEIKADSVILSWDVPEDNGGG 21190
Query: 1997 PLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
+ Y+I R+ ++T W V V F + +L ++ Y R+ A N G+S+PL S
Sbjct: 21191 EITCYSIEKRETSQTNWKMVCS-SVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVS 21248
Score = 212 bits (518), Expect = 1e-53
Identities = 227/896 (25%), Positives = 368/896 (41%), Gaps = 72/896 (8%)
Query: 1204 EFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
+ + + A +D L + + + W K ++ EK +L K+ T +I+ C D
Sbjct: 22558 DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSD 22617
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-- 1320
+YT + +A T + V V K++D S VT A+ P ++
Sbjct: 22618 SGKYTLTVKNASGTKAVSVMV-----KVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGG 22672
Query: 1321 -----WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA-DVEMN 1374
+IV + + + + S + ++ + I+++R N G VE
Sbjct: 22673 AEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESE 22732
Query: 1375 VTILDK----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV 1430
+ PSPPG P + I I W +PE+ G + I Y+V+ +E ++ W V
Sbjct: 22733 PIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKESLRWTRV 22792
Query: 1431 KN---ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP----- 1482
+ T+ + +L Y+FR AVN S+ SE + + + + P
Sbjct: 22793 NKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSERSNFISCREPSYTPGPPSAPR 22852
Query: 1483 ---TVEKPLKNITTEPNEDIELTCIFGGV--PQPKVT--WYRDGKKLKTAKATYENRXXX 1535
T + + T+P D T I G V Q K T WYR AT N
Sbjct: 22853 VVDTTKHSISLAWTKPMYDGG-TDIVGYVLEMQEKDTDQWYR-----VHTNATIRN-TEF 22905
Query: 1536 XXXXXXXXXXXXYKCIAFNDHGEVETS-CVVGIQQKPVITISN----EDIKQKHKV--GD 1588
++ A N G E S + I+ I I + +D+K+ + G
Sbjct: 22906 TVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGA 22965
Query: 1589 EWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEAS 1648
+ + G PPP + W K G L + I T E S++ + ++ R + KYTIEA
Sbjct: 22966 SLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLIVDKVNRYDAGKYTIEAE 23023
Query: 1649 NTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
N +G S V +KVYD P P V ++E+SR+SVTI W+ P DGG + Y +EK E
Sbjct: 23024 NQSGKKSATVLVKVYDTPG-PCPSVKVKEVSRDSVTITWEIPTIDGGAPINNYIVEKREA 23082
Query: 1709 DNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPS 1768
R K Y I L E + FRV+ +N G E E+ V+ + +VP
Sbjct: 23083 AM-RAFKTVTTKCSKTLYRISGLVEGTMHYFRVLPENIYGIGEPCETSDAVLVS--EVP- 23138
Query: 1769 XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARIQ 1827
+ +V + W +GGS + Y +E + G ++W
Sbjct: 23139 LVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHT 23198
Query: 1828 KLSINT--TYQFRIYARNEIGTSLPYTSDDKITIGK-----TLTPPSQPRNFVVSESTSR 1880
S+N Y FRI A+NE G S P + +T+ T+ + P+ + R
Sbjct: 23199 VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQK-TIHVPAGR 23257
Query: 1881 SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
V L P + P ++ ++ +S V V + I +D + +
Sbjct: 23258 PVEL--VIPIAGRPPPAASWFFAGSKLR-ESERVTVETHTKVAKLTIRETTIRDTGEYTL 23314
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
+N G + T + + L+K P PPT P++I + + + SW PE DGGAPL G
Sbjct: 23315 ELKNVTGTTSET-IKVIILDK----PGPPTGPIKIDEIDATSITISWEPPELDGGAPLSG 23369
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
Y + RD + W+ V + V F L+E + Y+ R+ A N G+ L+S+
Sbjct: 23370 YVVEQRDAHRPGWLPVSE-SVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 23424
Score = 208 bits (507), Expect = 2e-52
Identities = 223/960 (23%), Positives = 396/960 (41%), Gaps = 70/960 (7%)
Query: 750 ESVILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ VIL ++ P + W K+ K P K K+DG + ILK D G YT
Sbjct: 5536 DEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKTDGKKRML-ILKKALKSDIGQYTCD 5593
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
G +TS + +E+ + P + V E T + ++ + + + W
Sbjct: 5594 C----GTDKTSGKLDIEDREIKLVRP------LHSVEVMETETARFETEISEDDIHA-NW 5642
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
E + + +G+ LV+ N + +G A+N KSS RV V
Sbjct: 5643 KLKGEALLQTPDCEIKEEGKIHSLVLHNCRLD-QTGGVDFQAANV--KSSAHLRVKPRV- 5698
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
+ ++ L K G+T +C+ S+ + +WY K++ D EG+
Sbjct: 5699 -IGLLRPL-KDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLT 5756
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G ++ KD +T L VKE EF + L+D V+E A+LE E++ E A
Sbjct: 5757 LRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENA 5816
Query: 1046 DVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
V W ++G EI+K KK Y+ G +RKL I + + D Y+C +D + + VV
Sbjct: 5817 KVKWFKNGTEILKSKK--YEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVP 5874
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
E + L + +V + A FE EL++ +A V+WFKDG+EI+ + G + L
Sbjct: 5875 PHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILV 5934
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
I C LDD EYSCEV ++ + +LTV E FT L I V L E+
Sbjct: 5935 INKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLAN-IEVSETDTIKLVCEVSKPG 5993
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+V WYK I +T ++ ++++ +KR L+I+ +D Y C L S T KV+V
Sbjct: 5994 AEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRL--PSSRTDGKVKVH 6051
Query: 1285 EFPPKIVDYEREYRIKRG--SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
E + + + I G ++ + ++FP +W + K ++ D K
Sbjct: 6052 ELAAEFISKPQNLEILEGEKAEFVCSISKESFPV---QWKRDDKTLESGDKYDVIADGKK 6108
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS--PPGKPNILEIDSSSINIC 1400
L +K D G Y + + G A ++T+++K P K ++ + C
Sbjct: 6109 RVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNC 6164
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
NT + ++ E D++++I ++ I++ + + N
Sbjct: 6165 ---EVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRG 6221
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK 1520
+ S +++E ++ + +PLK+I T + + C + + W ++G+
Sbjct: 6222 ENVKSAAN---LIVEEEDLR---IVEPLKDIETMEKKSVTFWCKVNRL-NVTLKWTKNGE 6274
Query: 1521 KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE--VETSCVVGIQQKPVITISNE 1578
++ ++NR K F D GE V + + +I E
Sbjct: 6275 EV-----PFDNR--VSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTE 6327
Query: 1579 DIKQKHKVGDEWLVTAVIE---GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
++ AV V WY+NG +++ K+Y + IK+
Sbjct: 6328 FVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDC 6387
Query: 1636 KRSHSSKYTIEASNTAGTSSV---EVTLKVYDKPSK-PEGP----VIMREISRESVTIEW 1687
+ +Y + + + E+ +++ P E P V + E++++ V ++W
Sbjct: 6388 RLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQW 6447
Score = 207 bits (505), Expect = 4e-52
Identities = 228/1047 (21%), Positives = 410/1047 (39%), Gaps = 71/1047 (6%)
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
+E+ P + V + ++ + A V W KDG ++ + + ++
Sbjct: 18894 IEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVT 18953
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCT-----AILTVEEPSINFTLRLPEFILVPANTDAYL 1216
L I + +D G Y V NS + I+ ++ P +R+ E + + T ++
Sbjct: 18954 SLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDE-VSCDSITISWN 19012
Query: 1217 TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLI--IRKCTEDDQCEYTCV--LLD 1272
E D ++ Y + + + ++S RT I +R T + C
Sbjct: 19013 PPEY-DGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYG 19071
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
S ++ V E+P ++ + T+LV +Q ++ + + K
Sbjct: 19072 KSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHL--EYK 19129
Query: 1333 HTKPSIDSKSASLTIK----KVENTDAGI---YKLRLENNCGHADVEMN---VTILDKPS 1382
+ SK+ + I KV D G+ Y++ EN G + V D
Sbjct: 19130 ERSSILWSKANKILIADTQVKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCD 19189
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK--NITKTQTSI 1440
PPG+P + I S+++ W +P G + I Y+VE +E+ W+ NI +T +
Sbjct: 19190 PPGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEV 19249
Query: 1441 QNLKTNSSYRFRAYAVNEVD-ISDASETTEYYKVIKETKIQSPTVEKPLKN---ITTEPN 1496
L + Y FR +A N D +S+ SE+T +I + ++ P V +K I +
Sbjct: 19250 TELTEDQRYEFRVFARNAADSVSEPSESTG--PIIVKDDVEPPRVMMDVKFRDVIVVKAG 19307
Query: 1497 EDIELTCIFGGVPQPKVTWYRDG----KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIA 1552
E +++ G P P ++W +DG ++ +T + +N Y
Sbjct: 19308 EVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTL 19367
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIK--QKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
N G + + KP +I K W G ++ +Y
Sbjct: 19368 KNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGA---DIDYYHRK 19424
Query: 1611 NKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAGTSSV--EVTLKVYDKPS 1667
+ + + I E + + ++ +L + + + + N G V +K D +
Sbjct: 19425 KRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFT 19484
Query: 1668 KPEGPVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P P + +++ES+T+ W P DGG E++ Y IE+ E ++ RW++V + V
Sbjct: 19485 VPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNK--KPVYD 19542
Query: 1726 YCIQK--LNENCEYMFRVIAQNPVGFSEALESEPIV-IKTALDVPSXXXXXXXXXXIDNE 1782
++ L E CEY +RV A+N G S E+ P++ + + +PS
Sbjct: 19543 LRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDS-GKT 19601
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXXXXXXXXA-RIQKLSINTTYQFRIY 1840
++ I W +GG+PI Y VE K+ + WK I L+ Y FR+
Sbjct: 19602 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 19661
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
+ N++G S P S D + P + + ++ +T G P+ N
Sbjct: 19662 SVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPN- 19720
Query: 1901 IIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLE 1960
++ K V S IEN D + ++ +N + + T +
Sbjct: 19721 VLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLT-----LVV 19775
Query: 1961 KHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD 2020
K P PPT + ++ V + SW PE DGGAP+ Y+I R+ +K W+ V +
Sbjct: 19776 KVLDTPGPPTN-ITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTN-N 19833
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVX 2080
N L + + +L E Y R+ NE G+ P E+ E K+ E+P ++
Sbjct: 19834 CNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKI--------TEKPSPPEKLG 19885
Query: 2081 XXXXXXXXXXXXWLR-EHNMDADIRSY 2106
WL+ EH+ + I Y
Sbjct: 19886 VTSISKDSVSLTWLKPEHDGGSRIVHY 19912
Score = 204 bits (499), Expect = 2e-51
Identities = 228/937 (24%), Positives = 390/937 (41%), Gaps = 70/937 (7%)
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
+ ++ K++IY + + GE + G K + E ++ LR I ++
Sbjct: 15326 ENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFV 15385
Query: 1217 TVE-IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
++ PD +V W + E +K ++ S LI+ D +Y + ++
Sbjct: 15386 PIKGRPDP--EVKWARDHG--ESLDKASIESASSYTLLIVGNVNRFDSGKYILTVENSSG 15441
Query: 1276 TTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH 1333
+ + V V++ P D + + K + VTL D P + + + I++K +
Sbjct: 15442 SKSAFVNVRVLDTPGPPQDLKVKEVTK--TSVTLTWDP---PLLDGGSKIKNYIVEKRES 15496
Query: 1334 TKPSIDSKSASL--TIKKVENTDAGI---YKLRLENNCG---HADVEMNVTILDKPSPPG 1385
T+ + + + + T KV+ G +++ EN G A+ +V ++P PPG
Sbjct: 15497 TRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPG 15556
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKT 1445
K ++++ +S+++ W++PE+ G S I+ Y+VE Q + +W + + T+ +I L
Sbjct: 15557 KITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQ 15616
Query: 1446 NSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF 1505
Y FR A NE ISD + + VI + + P + T ED+++ F
Sbjct: 15617 GEEYSFRVSAQNEKGISDPRQLS--VPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPF 15674
Query: 1506 GGVPQPKVTWYRDGKKLK-----TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
G P P VTW++D LK A++T EN Y N GE
Sbjct: 15675 IGRPTPAVTWHKDNVPLKQTTRVNAEST-ENNSLLTIKDACREDVGHYVVKLTNSAGEAI 15733
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN----D 1616
+ V + KP +K DE ++ PP+ Y G+ + N
Sbjct: 15734 ETLNVIVLDKP--GPPTGPVKM-----DEVTADSITLSWGPPK---YDGGSSINNYIVEK 15783
Query: 1617 KEYNITTKEKTS------VIRIKELKRSHSSKYTIEASNTAGTSSV---EVTLKVYD-KP 1666
++ + TT + S I+ LK ++ I A N G S+ E T+ Y K
Sbjct: 15784 RDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKV 15843
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
P G ++ SR+S+ ++W P+ DGG + Y +E+ E ++ W+K+ +
Sbjct: 15844 PGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIPQTKF 15903
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
L E EY FRV A+N VG + + SE V + D P + SV
Sbjct: 15904 KTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPG----RPEAIIVTRNSVT 15959
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQ--EGKKWKXX-XXXXXXXARIQKLSINTTYQFRIYAR 1842
+ W +GGS I Y VE K+ EG+ K + L + Y+FR+ AR
Sbjct: 15960 LQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIAR 16019
Query: 1843 NEIGT-SLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
N G S P S IT + PP + ++ + G PI I
Sbjct: 16020 NAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPT-I 16078
Query: 1902 IEFKTVKGKSWTKIVTVGGS--VHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
K + S T + + + +++ D + + A+N G T + V L
Sbjct: 16079 QWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKV-L 16137
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
++ P PP P+ I V + +W P DGG+ ++ Y + R+ ++ +W V
Sbjct: 16138 DR----PGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVV-DA 16192
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
+V TL + L E + Y RI A N+ G+ EPLES+
Sbjct: 16193 NVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESE 16229
Score = 204 bits (499), Expect = 2e-51
Identities = 223/926 (24%), Positives = 382/926 (41%), Gaps = 55/926 (5%)
Query: 1161 QKLKIYDCDLDDAG--EYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
Q+ KI C L+ G E + G K L E P ++ L + I+V A A + +
Sbjct: 17492 QEYKIRVCALNKVGLGEATSVPGTVKPEDKL--EAPELDLDSELRKGIVVRAGGSARIHI 17549
Query: 1219 EIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
+ ++TW +++ E T+K + V L I C +D +Y L ++ +
Sbjct: 17550 PFKGRPMPEITWSREEG--EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSK 17607
Query: 1278 K--LKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ V+V++ P + +K + + ++ P + V + +I K + T+
Sbjct: 17608 SAFVTVKVLDTPGP----PQNLAVKEVRKDSAFLVWEP-PIIDGGAKVKNYVIDKRESTR 17662
Query: 1336 PSIDSKSA--SLTIKKVEN-TDAGIYKLRL--ENNCG-HADVEM--NVTILDKPSPPGKP 1387
+ + S+ S T KVEN T+ IY R+ EN G VE V + PSPPGK
Sbjct: 17663 KAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKV 17722
Query: 1388 NILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNS 1447
+ ++ +S ++ W++PE+ G S ++ YVVE Q T +W V + L +
Sbjct: 17723 TLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQ 17782
Query: 1448 SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
Y+FR A NE SD + K+ IQ P+++ P + + ED+++ G
Sbjct: 17783 EYQFRVKAYNEKGKSD-PRVLGVPVIAKDLTIQ-PSLKLPFNTYSIQAGEDLKIEIPVIG 17840
Query: 1508 VPQPKVTWYRDGKKLK-TAKATYENRXXXX---XXXXXXXXXXXYKCIAFNDHGEVETSC 1563
P+P ++W +DG+ LK T + E Y A N G +
Sbjct: 17841 RPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENL 17900
Query: 1564 VVGIQQK---PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
V + +K PV + +++ V W A G I K +
Sbjct: 17901 SVIVLEKPGPPVGPVRFDEVSADFVV-ISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVS 17959
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS----SVEVTLKVYDKPSKPEGPVIMR 1676
T T I+I +LK ++ I A N G S S V ++ K P G +
Sbjct: 17960 ATVARTT--IKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVT 18017
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCE 1736
IS++ + ++W P++DGG ++ Y +E+ E ++ W+K+ + L+E E
Sbjct: 18018 SISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLE 18077
Query: 1737 YMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNG 1795
Y F+V A+N VG + + SE V + D P I +V + W +G
Sbjct: 18078 YEFKVSAENIVGIGKPSKVSECFVARDPCDPPG----RPEAIVITRNNVTLKWKKPAYDG 18133
Query: 1796 GSPIIDYKVEIKQ--EGKKWKXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGT-SLPY 1851
GS I Y VE K +G+ K + L + Y+FR+ ARN G S P
Sbjct: 18134 GSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPS 18193
Query: 1852 TSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS 1911
S IT + P+ + + + G PI + + + +
Sbjct: 18194 DSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEE 18253
Query: 1912 WTKIVTVGGSVHEH--CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP 1969
+ + ++ + +++ D + + N G T+S + + K P P
Sbjct: 18254 TAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGG----TKSIPITV-KVLDRPGSP 18308
Query: 1970 TAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIR 2029
PL++ V + +W P DGGA + Y I R+ ++ W +V +V L + +
Sbjct: 18309 EGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV-STEVQALNYKVT 18367
Query: 2030 DLSENHTYMIRIYARNEIGLSEPLES 2055
L + Y+ R+ A N+ G+ EPLES
Sbjct: 18368 KLLPGNEYIFRVMAVNKYGIGEPLES 18393
Score = 203 bits (496), Expect = 5e-51
Identities = 186/694 (26%), Positives = 290/694 (41%), Gaps = 36/694 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQT 1438
P P P + + S+ + W+ P + G S I+ YV+E ++ + W I + +
Sbjct: 16240 PDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRL 16299
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP--- 1495
+ L N Y FR A N +S+ S + Y K P + +IT
Sbjct: 16300 RVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFL 16359
Query: 1496 --NEDI-ELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIA 1552
++ I + C G K G+ T N+ ++ A
Sbjct: 16360 SWSKPIYDGGCEIQGYIVEKCD-VNVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICA 16418
Query: 1553 FNDHGEVETSCVVG---IQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVI 1605
N G E + V G +++K P I + E K + + G + I+G P PEV
Sbjct: 16419 INKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVK 16478
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K ++ + ++T+ TS++ + + R S KYT+ N++GT S VT++V D
Sbjct: 16479 WGKVDGEIRDAAIIDVTSSF-TSLV-LDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDT 16536
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
PS P + + EI+++SV+I W+PPL DGG ++ Y +EK E + V + +
Sbjct: 16537 PSPPVN-LKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVV-TNCHKNS 16594
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFS-EALESEPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
+ I +L E C Y FRV A+N G A ++PI + P + SV
Sbjct: 16595 WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPG----KITVDDVTRNSV 16650
Query: 1785 YITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
++W E +GGS II Y VE++ + +KW A I L+ Y FR+ A N
Sbjct: 16651 SLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVN 16710
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
E G S P + I + K L + S S LK P S P + +
Sbjct: 16711 EKGRSDPRSLAVPI-VAKDLVIEPDVKPAFSSYSVQVGQDLKMEVPISGRPKPTITWTKD 16769
Query: 1904 FKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
+ K T+I VT + I+ + D + I+ N VG + V L+K
Sbjct: 16770 GLPL--KQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVG-QKTASIEIVTLDK- 16825
Query: 1963 ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
P PP P++ V + + SW P + GG + Y + RD T T+W +V V
Sbjct: 16826 ---PDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVW-DVVSATVA 16881
Query: 2023 TLKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
+ L Y RI+A N G S LESD
Sbjct: 16882 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESD 16915
Score = 202 bits (494), Expect = 8e-51
Identities = 177/674 (26%), Positives = 272/674 (40%), Gaps = 44/674 (6%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMN 1374
P P W + K + ++ +KS L IK D G Y + N+CG
Sbjct: 8635 PVPTKVWTKEEGELDKDRVVIDNVGTKS-ELIIKDALRKDHGRYVITATNSCGSKFAAAR 8693
Query: 1375 VTILDKPSP--PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN 1432
V + D P P KP + +N W +PE+ G S I +++E ++ W
Sbjct: 8694 VEVFDVPGPVLDLKPVVTNRKMCLLN--WSDPEDDGGSEITGFIIERKDAKMHTWRQPIE 8751
Query: 1433 ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT----VEKPL 1488
+++ I L Y+FR A N+ E V SP E+
Sbjct: 8752 TERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERQR 8811
Query: 1489 KNITTEPNEDIELTCIFGGVP-QPKVTWYR--DGKKLKTAKATYENRXXXXXXXXXXXXX 1545
IT + E GG P Q + R D +
Sbjct: 8812 STITLDWKEPRSN----GGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQM 8867
Query: 1546 XXYKCIAFNDHGEVETSCVVGI-----QQKPVITI--SNEDIKQKHKVGDEWLVTAVIEG 1598
++ A N+ GE E S + + + P I + S K K G+ + A + G
Sbjct: 8868 YEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTG 8927
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTS------VIRIKELKRSHSSKYTIEASNTAG 1652
+P P++ W KN +E + TKE+ S + I + R YT+ ASN G
Sbjct: 8928 LPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLG 8987
Query: 1653 TSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR 1712
+ V ++VYD+PS P + + +I ES + W PLD+GG E+T Y I+K + +
Sbjct: 8988 SVFRNVHVEVYDRPSPPRN-LAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKK 9046
Query: 1713 --WIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
W +V + + + Y I KL N +Y FRV A N G S+ +S+ +VI+ +P
Sbjct: 9047 AEWEEVTNTAVE-KRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQDPYRLPGPP 9105
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKL 1829
S+ ++W P NGGSPI Y +E ++EG W ++ +
Sbjct: 9106 GKPKVLARTKG-SMLVSWTPPLDNGGSPITGYWLEKREEGSPYWSRVSRAPITKVGLKGV 9164
Query: 1830 SINTT-------YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSV 1882
N YQFR A N G P D G + PP P V + T S+
Sbjct: 9165 EFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSI 9224
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVH--EHCIENIKEKDEIIFRI 1940
+L W P +GGSPI YI+E + W ++ + E + N+KE + FR+
Sbjct: 9225 SLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECVVPNLKELRKYRFRV 9284
Query: 1941 SAENTVGVSLPTES 1954
A N G S P+++
Sbjct: 9285 KAVNEAGESEPSDT 9298
Score = 202 bits (494), Expect = 8e-51
Identities = 217/903 (24%), Positives = 372/903 (41%), Gaps = 67/903 (7%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVT-WYKKKSVIEDTEKFTLISDVKKRT 1252
PS+ ++L E ++V A T I + W S I+ E +T+ +D
Sbjct: 11011 PSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV 11070
Query: 1253 LIIRKCTEDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD 1310
L I+ C D EY + +A T + + V++ P I + + +
Sbjct: 11071 LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTG---PINILDVTPEHMTIS 11127
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPS--IDSKSASLTIKKVENTDAG---IYKLRLENN 1365
+Q ++N I++K K + + S +S T K+ + G ++++R EN
Sbjct: 11128 WQPPKDDGGSPVINY-IVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENK 11186
Query: 1366 CGHAD-VEMNVTI----LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
G ++ T+ PSPPGKP + +I ++ + W P++ G S I Y +E +
Sbjct: 11187 IGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERR 11246
Query: 1421 EIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK 1478
E+ T +W+ V I + + L ++Y FR +A N +S S +++ K + K
Sbjct: 11247 EV-TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIK 11305
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXX 1538
P + LK+ + E D+ T P + + + +K TA+ N+
Sbjct: 11306 PPGPPINPKLKDKSRE-TADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQ 11364
Query: 1539 XXXXX------XXXXYKCIAFNDHGE------VETSCVVGIQQKPVIT--ISNEDIKQKH 1584
++ A N GE E+ I P + ++ D+
Sbjct: 11365 CAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITV- 11423
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VG + A ++G P P++ W K G L +K ++ ++IKE R+ KY
Sbjct: 11424 RVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYI 11483
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
I A N++G + + V D+P P + + +++E+ TI W+ PLD+GG E+T + +E
Sbjct: 11484 ISAKNSSGHAQGSAIVNVLDRPG-PCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVE 11542
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQ-KLNENCEYMFRVIAQNPVGFSEALESE-PIVIKT 1762
+P+ W VA DV I+ L N EY FRV A+N VG +E++ PI+
Sbjct: 11543 YRKPNQKGWSIVAS---DVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAIN 11599
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXX 1821
+D P VY+ W + +GGSP + Y VE + +G W+
Sbjct: 11600 PIDRPGEPENLHIADK-GKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSI 11658
Query: 1822 XXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTS 1879
+ + N Y+FR+ +NE G S + +++ + + L P V+ S
Sbjct: 11659 KETHYMVDRCVENQIYEFRVQTKNEGGES-DWVKTEEVVVKEDLQKP------VLDLKLS 11711
Query: 1880 RSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-------VTVGGSVHEHCIENIKE 1932
+T+K + E K K T + + + + K
Sbjct: 11712 GVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKR 11771
Query: 1933 KDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW 1992
D + ++A NT G + + +V L+K P L+I V S+ W PE
Sbjct: 11772 SDGGKYVVTATNTAGSFVAYATVNV-LDKPG-----PVRNLKIVDVSSDRCTVCWDPPED 11825
Query: 1993 DGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
DGG + Y I + TK M V T + L E + Y+ R+ A N+IG P
Sbjct: 11826 DGGCEIQNY-ILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTGPP 11884
Query: 2053 LES 2055
ES
Sbjct: 11885 TES 11887
Score = 202 bits (493), Expect = 1e-50
Identities = 182/753 (24%), Positives = 322/753 (42%), Gaps = 44/753 (5%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V E + EC + P+ WL +EI D+ + + H V+K +
Sbjct: 5354 VFEKDEAKFECEVSREPKT-FRWLKGTQEITGDDRFELIKDGTKHSM--VIKSAAFE--D 5408
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
E Y A ++ L I+ I+ + + PLK + ++ ES + + ++ +
Sbjct: 5409 EAKYMFEAEDKHTSGKL-IIEGIRL------KFLTPLKDVTAKEKESAVFTVEL-SHDNI 5460
Query: 765 TITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
+ W KN++ + +++ + +G THSIT K + D ++A + A +T
Sbjct: 5461 RVKWFKNDQRLHTTRSVSMQDEGKTHSITF-KDLSIDDTSQIRVEAMGMS----SEAKLT 5515
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
V E P F + Q+ T EK + L +++ P + W+++ + I PS+
Sbjct: 5516 VLEGD------PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVI 5568
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE 941
DG+ L++ + D G Y C G ++ I+ ++ V+ L S E
Sbjct: 5569 KTDGKKRMLILKKA-LKSDIGQYTC----DCGTDKTSGKLDIEDREIKLVRPLH-SVEVM 5622
Query: 942 EGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
E +T E + S + W + + EI +EG+ G +
Sbjct: 5623 ETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQ 5682
Query: 1001 VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKK 1060
+ ++S L VK + +R L+D V + A + E++ E V W G+ ++P
Sbjct: 5683 AANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPS- 5741
Query: 1061 NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNK 1120
+K G + L +R+ + D GE +D A + V E P E L++Q V +
Sbjct: 5742 DKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEE 5801
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
G A E E+++ +A V+WFK+G+EI S ++ DG+ +KL I+DC +D Y+C+
Sbjct: 5802 GATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDA 5861
Query: 1181 GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE 1240
+ K + L V P + F L + + V A E+ E V W+K + I+ +
Sbjct: 5862 KDFKTSCNLNVVPPHVEFLRPLTD-LQVREKEMARFECELSRENAKVKWFKDGAEIKKGK 5920
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV--EVVEFPPKIVDYEREYR 1298
K+ +IS R L+I KC DD+ EY+C + A+++ L V E F + + E
Sbjct: 5921 KYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVSE- 5979
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
+D LV + P W + I + + + + L I+ DAG Y
Sbjct: 5980 ----TDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNY 6035
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
RL ++ V+++ + S P ILE
Sbjct: 6036 NCRLPSSRTDGKVKVHELAAEFISKPQNLEILE 6068
Score = 199 bits (486), Expect = 8e-50
Identities = 172/697 (24%), Positives = 288/697 (41%), Gaps = 38/697 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK---TQ 1437
P PP P++ + S ++ W +P G I YVVE+Q++ WI T TQ
Sbjct: 14176 PGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ 14235
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE 1497
+ +L+T Y FR A+N+ + + + + V +E + + +
Sbjct: 14236 FVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGL 14295
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXX-XXXXXYKCIAFNDH 1556
I + G P P+VTW +D LK +A EN K + ++
Sbjct: 14296 SIRIFVPIKGRPAPEVTWTKDNINLKN-RANIENTESFTLLIIPECNRYDTGKFVMTIEN 14354
Query: 1557 GEVETSCVVGIQ----QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
+ S V ++ PV+ + DI K V W + + G + Y +
Sbjct: 14355 PAGKKSGFVNVRVLDTPGPVLNLRPTDIT-KDSVTLHWDLPLIDGG---SRITNYIVEKR 14410
Query: 1613 LENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS-VEVT--LKVYDKPSK 1668
K Y+ TTK ++ L + + A N G E T +K + PS
Sbjct: 14411 EATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP 14470
Query: 1669 PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCI 1728
P+ IM +I++ +V++ W P DGG ++T Y IE +++W + V + +E +
Sbjct: 14471 PDSLNIM-DITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV-KGLECV-V 14527
Query: 1729 QKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXI-----DNES 1783
+ L E EY F+V+A N G S ES P+++K +P + DN
Sbjct: 14528 RNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIK 14587
Query: 1784 VYITWFPSEKNGGSPIIDYKV--EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
V I K P + +K +I ++ ++ I + + + + + A
Sbjct: 14588 VEIPVLGRPK----PTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTA 14643
Query: 1842 RNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
RN +G + I + PP+ P F E +S VT W PE++GG PI+NY+
Sbjct: 14644 RNIVGEVGDVIT---IQVHDIPGPPTGPIKF--DEVSSDFVTFSWDPPENDGGVPISNYV 14698
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
+E + +W ++ T + + E FR+ A+N GV S +
Sbjct: 14699 VEMRQTDSTTWVELATTVIRT-TYKATRLTTGLEYQFRVKAQNRYGVGPGITSAWIVANY 14757
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
VP PP P ++ V + + SW P DGG+P+LGY++ ++ +W V K V
Sbjct: 14758 PFKVPGPPGTP-QVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALV 14816
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
F L++ Y R+ A N G S+P + EP
Sbjct: 14817 PGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEP 14853
Score = 198 bits (483), Expect = 2e-49
Identities = 131/433 (30%), Positives = 196/433 (45%), Gaps = 19/433 (4%)
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN--GNKLENDKEYNITTKEK 1626
QKPV+ + + K GD + A + G P PEV W K+ L I T+
Sbjct: 11702 QKPVLDLKLSGVLTV-KAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRAD 11760
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+S + + KRS KY + A+NTAG+ T+ V DKP I+ ++S + T+
Sbjct: 11761 SSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIV-DVSSDRCTVC 11819
Query: 1687 WKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNP 1746
W PP DDGG E+ Y +EK E W + T + +L E EY+FRV A+N
Sbjct: 11820 WDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGT-TVTRLIEGNEYIFRVRAENK 11878
Query: 1747 VGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
+G ES+P++ KT D P + E + + W P E +GG I Y +E
Sbjct: 11879 IGTGPPTESKPVIAKTKYDKPGRPDPPEVTK-VSKEEMTVVWNPPEYDGGKSITGYFLEK 11937
Query: 1807 KQE-GKKWKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTL 1863
K++ +W R +Q L + YQFR+ A NEIG P + +
Sbjct: 11938 KEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPI 11997
Query: 1864 TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK-----TVKGKSWTKIVTV 1918
PP P NF V ++T S+TL W +P +GG+PI Y++E + + W +
Sbjct: 11998 EPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAA 12057
Query: 1919 GGSVH-EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM 1977
V E + ++ E E FR+ A+N VG+ P E + K + PP L+ M
Sbjct: 12058 AQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKE--ILEPPEIDLDASM 12115
Query: 1978 VGSNIVMTSWGTP 1990
+V+ G P
Sbjct: 12116 --RKLVIVRAGCP 12126
Score = 198 bits (482), Expect = 2e-49
Identities = 194/869 (22%), Positives = 357/869 (41%), Gaps = 53/869 (6%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVV 1284
VTW + + ++ T+ + +++I+ C Q Y+ + + K + V+V+
Sbjct: 10059 VTWNMNERTLP--QEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVL 10116
Query: 1285 EFP-PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
+ P P + +T P +++ + + T +
Sbjct: 10117 DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQ 10176
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHAD-VEMNVTILDK-----PSPPGKPNILEIDSSSI 1397
+ T++ + A +++ EN+ G VE + ++ + P P + E+ +++
Sbjct: 10177 NATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTV 10236
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYA 1455
+ W+ P+ G S II YV+E + I T ++ V N + + +++ LK +Y +R A
Sbjct: 10237 TLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSA 10296
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNEDIELTCIFGGVPQPKVT 1514
VN V S T+ + + ++ PT+ ++ +T E LT + G P+PKV+
Sbjct: 10297 VNIVGQGKPSFCTK--PITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVS 10354
Query: 1515 WYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ- 1569
W++D + +T T Y + N G + C V +
Sbjct: 10355 WFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDH 10414
Query: 1570 --KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
PV +S +++ + + V W G I K ++ D +T+
Sbjct: 10415 PGPPVGPVSFDEVTKDYMV-ISWKPPLDDGGSKITNYIIEK--KEVGKDVWMPVTSASAK 10471
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSS--VEVTLKVYDK---PSKPEGPVIMREISRES 1682
+ ++ +L + I A N G S V ++K D+ P P+ P++ E++++S
Sbjct: 10472 TTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIV-TEVTKDS 10530
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEYMFRV 1741
+ W P DGG +T Y +EK E + RW +V D + + L E C+Y FRV
Sbjct: 10531 ALVTWNKP-HDGGKPITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRV 10589
Query: 1742 IAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
A+N +G + + S+P+ K + PS N SV +TW P +GGS I+
Sbjct: 10590 SAENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCN-SVDLTWQPPRHDGGSKIL 10648
Query: 1801 DYKVEIKQEG-KKWKXXXXX----XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDD 1855
Y VE ++ G ++W+ ++ L TY+FR+ A N G S P +
Sbjct: 10649 GYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPE 10708
Query: 1856 KITIGKTLTPPS--QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWT 1913
+ + L PP N + TL+ + P + E + K+
Sbjct: 10709 PVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARI 10768
Query: 1914 KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPL 1973
+ VG + I N +D I+ ++ EN G S + + L+K P PP L
Sbjct: 10769 DVTPVGSKLE---IRNAAHEDGGIYSLTVENPAG-SKTVSVKVLVLDK----PGPP-RDL 10819
Query: 1974 EIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSE 2033
E+ + + +W P DGG+ + Y + RDV W + F + L+E
Sbjct: 10820 EVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHF-AKHLNE 10878
Query: 2034 NHTYMIRIYARNEIGLSEPLESDEPFKVI 2062
+ Y+ R+ A N+ G +E+ +P K +
Sbjct: 10879 GNQYLFRVAAENQYGRGPFVETPKPIKAL 10907
Score = 196 bits (479), Expect = 5e-49
Identities = 168/659 (25%), Positives = 291/659 (44%), Gaps = 41/659 (6%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVE 1192
++W++ G E+ S +++ DG+ L + + +D G Y+C EVG + ++ L ++
Sbjct: 24067 IKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ 24126
Query: 1193 E-PSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKK 1250
P + L E + L V + +TW+ + +++++E T+ +
Sbjct: 24127 ATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHY 24186
Query: 1251 RTLIIRKCTEDDQC-EYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
L+++ +Y L + T L VE+ + P K + + S V
Sbjct: 24187 THLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAV-- 24244
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPS---IDSKSASLTIKKVENT--DAGIY-KLR 1361
+ ++ WI N +++KC+ + + + S + S+T ++ N +AG Y ++
Sbjct: 24245 -ISWKPPADDGGSWITNY-VVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVS 24302
Query: 1362 LENNCGHAD-VEMNVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
+N G +D +E++ ++ +KP PGKP I + S + W P + G + I Y
Sbjct: 24303 AQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNY 24362
Query: 1416 VVEYQEIDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
+E +E +WISV + I +T S++NL Y FR N S+ SE +E
Sbjct: 24363 YLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITP 24422
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRX 1533
+ IQ+P ++ L+N+ + L C G P+P V WYR GK++ Y +
Sbjct: 24423 KSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQE 24482
Query: 1534 XXXX------XXXXXXXXXXYKCIAFNDHGEVE--TSCVVGIQQKPVITISNEDIKQKHK 1585
Y+ A N G V S V + K + + E + H
Sbjct: 24483 FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHA 24542
Query: 1586 V-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN-ITTKEKTSVIRIKELKRSHSSKY 1643
+ G+ + G P P + W K + ++N+ Y I T+ TS++ ++R + Y
Sbjct: 24543 LRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFY 24602
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAI 1703
+ A N G V L V D P P G V + + SR+SV + W P DGG ++T Y +
Sbjct: 24603 VVCAKNRFGIDQKTVELDVADVPDPPRG-VKVSDASRDSVNLTWTEPASDGGSKITNYIV 24661
Query: 1704 EKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIK 1761
EK RW++V R+ Y + L Y FRVIA+N G S+ E SEP + K
Sbjct: 24662 EKCATTAERWLRVGQA-RETR-YTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITK 24718
Score = 195 bits (476), Expect = 1e-48
Identities = 189/713 (26%), Positives = 310/713 (43%), Gaps = 69/713 (9%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKTQ 1437
P+PP P + + SS+++ W +P G S II Y+VE + D+ W+ +N+ KT+
Sbjct: 13092 PAPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTR 13151
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITTE 1494
+ L ++ Y+FR YAVN++ SD S+ + K + + P E K +
Sbjct: 13152 FEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPD--KHYPKDILIPPEGEHDADLRKTLILR 13209
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTA-----KATYENRXXXXXXXXXXXXXXXYK 1549
+ L G P PK+TW + L+ K+T + Y
Sbjct: 13210 AGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKST-DFDTFLRCENVNKYDAGKYI 13268
Query: 1550 CIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT---AVIEGIPPPEVIW 1606
N G+ E + VV + P I N +K+ K D VT +I+G P +I
Sbjct: 13269 LTLENSCGKKEYTIVVKVLDTPGPPI-NVTVKEISK--DSAYVTWEPPIIDGGSP--IIN 13323
Query: 1607 YKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD 1664
Y + K ++ T E KTS R+ L+ S + + A N G T
Sbjct: 13324 YVVQKRDAERKSWSTVTTECSKTS-FRVPNLEEGKSYFFRVFAENEYGIGDPGETRDAV- 13381
Query: 1665 KPSKPEGPVI---MREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
K S+ GPV+ +R +S+ S +I WK P DGG + Y ++ + N+W +V
Sbjct: 13382 KASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVD-FLTEENKWQRVMK-SL 13439
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDN 1781
++ Y + L E EY FRV A+N G E SE I + DV + +D
Sbjct: 13440 SLQ-YSAKDLTEGKEYTFRVSAENENG--EGTPSE-ITVVARDDVVAPD--------LDL 13487
Query: 1782 ESVYITWFPSEKNGGSPIIDYKVEIKQEGK-----KWKXXXXXXXXXARI--QKLSINTT 1834
+ + + +++N +++++I +GK WK R+ + ++NTT
Sbjct: 13488 KGLPDLCYLAKENS-----NFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTT 13542
Query: 1835 YQFRIYARNEIGT------SLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWT 1887
+++ G ++ T + I+I K + P P + E T+ ++TLKW
Sbjct: 13543 LIVYDCQKSDAGKYTITLKNVAGTKEGTISI-KVVGKPGIPTGPIKFDEVTAEAMTLKWA 13601
Query: 1888 EPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC--IENIKEKDEIIFRISAENT 1945
P+ +GGS ITNYI+E + W VT +V + + + E E FR+SAEN
Sbjct: 13602 PPKDDGGSEITNYILEKRDSVNNKW---VTCASAVQKTTFRVTRLHEGMEYTFRVSAENK 13658
Query: 1946 VGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAI 2005
GV +S+ + VP P P I V + V +W P+ GG+P+ GY++
Sbjct: 13659 YGVGEGLKSEPIVARHPFDVPDAPPPP-NIVDVRHDSVSLTWTDPKKTGGSPITGYHLEF 13717
Query: 2006 RDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
++ +W K + F + L+E Y R+ A N G+ +P EP
Sbjct: 13718 KERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEP 13770
Score = 195 bits (476), Expect = 1e-48
Identities = 175/699 (25%), Positives = 298/699 (42%), Gaps = 44/699 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKTQ 1437
P PP P + + SS+++ W +P G + + YVVE +E EW + + Q
Sbjct: 18506 PGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQ 18565
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITTE 1494
++ LK N+ Y FR A+N + + + T V+ + +I+ P +E K +
Sbjct: 18566 FTVTKLKENTEYNFRICAINSEGVGEPA--TLPGSVVAQERIEPPEIELDADLRKVVVLR 18623
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCI 1551
+ + L G P+P+V W + + + T +A E + Y
Sbjct: 18624 ASATLRLFVTIKGRPEPEVKWEK-AEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLT 18682
Query: 1552 AFNDHGEVETSCVVGIQQKP--VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
N+ G V + P + ++ ++K K V W +I+G ++ Y
Sbjct: 18683 LENNSGSKTAFVNVRVLDSPSAPVNLTIREVK-KDSVTLSW-EPPLIDG--GAKITNYIV 18738
Query: 1610 GNKLENDKEY-NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS-SVEVTLKV-YDKP 1666
+ K Y IT + RI+ L+ S + + ASN G E T V +P
Sbjct: 18739 EKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEP 18798
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
P G V + +++R + TI+W+ P DGG ++T Y +E + +W V + +E
Sbjct: 18799 PLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQV-KTLEA- 18856
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
I L EY+FRV A N G S+ + P++ + PS E +
Sbjct: 18857 TISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLK 18916
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXAR-IQKLSINTTYQFRIYARNE 1844
I P + G P V +++G+ K ++ + LSI ++ +
Sbjct: 18917 ID-VPFK---GRP--QATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEA------SKED 18964
Query: 1845 IGTSLPYTSDD--KITIGKT---LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
+GT S+ IT+ T L P P + E + S+T+ W PE +GG I+N
Sbjct: 18965 VGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISN 19024
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
YI+E K +W IV+ + I + E FR+ AEN G S +ES +V
Sbjct: 19025 YIVEKKETTSTTW-HIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVA 19083
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
E + P PP P + S +++T W P DGG+ ++GY++ ++ + +W + K+
Sbjct: 19084 EYPFSPPGPPGTPKVVHATKSTMLVT-WQVPVNDGGSRVIGYHLEYKERSSILWSKANKI 19142
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ + + L E Y R+YA N G+ + +S EP
Sbjct: 19143 LIADTQVKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEP 19181
Score = 194 bits (474), Expect = 2e-48
Identities = 212/907 (23%), Positives = 361/907 (39%), Gaps = 56/907 (6%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVK 1249
+E P I+ L L + I + A L V I T +V W K I D + S
Sbjct: 16440 LEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFT 16499
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
+L++ D +YT L ++ T + V V++ P V+ + K +T
Sbjct: 16500 --SLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITW 16557
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCG 1367
+IV + + + + S I +++ + +++ EN G
Sbjct: 16558 EPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYG 16617
Query: 1368 ---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
A + + + P PPGK + ++ +S+++ W +PE+ G S II Y+VE Q +
Sbjct: 16618 IGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHS 16677
Query: 1425 TEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
+W + Q I NL Y FR AVNE SD ++ + + P V
Sbjct: 16678 EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLA--VPIVAKDLVIEPDV 16735
Query: 1485 EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX 1544
+ + + + +D+++ G P+P +TW +DG L K T
Sbjct: 16736 KPAFSSYSVQVGQDLKMEVPISGRPKPTITWTKDGLPL---KQTTRINVTDSLDLTTLSI 16792
Query: 1545 XXXYKCIAFNDHGEVETSCVVGIQQK----PVITISNED-IKQKHKVGDEWLVTAVIEGI 1599
+K +D G+ + + QK ++T+ D K K D + +
Sbjct: 16793 KETHK----DDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWN 16848
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTS------VIRIKELKRSHSSKYTIEASNTAGT 1653
PP + N + ++ T + S +++ +LK ++ I A N G
Sbjct: 16849 PPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQ 16908
Query: 1654 S-SVEVTLKVYDKPSK---PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
S ++E V P K P G IS++S+ I+W P+++GG + Y +E+ E +
Sbjct: 16909 SFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERN 16968
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPS 1768
+ W KV + Q L E EY FRV A+N VG +A + SE V + D P
Sbjct: 16969 SILWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPG 17028
Query: 1769 XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGKKWKXXXXXXXXXA-R 1825
+ + + W +GGS I Y VE + +G+ K
Sbjct: 17029 ----TPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFT 17084
Query: 1826 IQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKTLTPP--SQPRNFVVSESTSRSV 1882
+ L+ + Y+FR+ A+N G S P S IT + P S F + +
Sbjct: 17085 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGE 17144
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
T + P ++ K ++ + +I +++ D + + A
Sbjct: 17145 TFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKA-LLIVKDAIRIDGGQYILRA 17203
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
N G ++S V + K P PP P+++ V S +W P DGG+ + Y
Sbjct: 17204 SNVAG----SKSFPVNV-KVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYV 17258
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES-----DE 2057
+ R+ ++ W V +V T + L E + Y+ RI A N+ G+ EPLES
Sbjct: 17259 VEKRETSRLAWTVVAS-EVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKN 17317
Query: 2058 PFKVIPG 2064
PF V+PG
Sbjct: 17318 PF-VLPG 17323
Score = 192 bits (467), Expect = 2e-47
Identities = 176/700 (25%), Positives = 303/700 (43%), Gaps = 46/700 (6%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK---NIT 1434
+D P PP K I + SSI + W +P G S + YVVE ++ + EW +V +
Sbjct: 20667 IDPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVR 20726
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNI 1491
T+ + NLK +Y FR AVN + E E V + +++P ++ + ++
Sbjct: 20727 TTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNE--PVQAKDILEAPEIDLDVALRTSV 20784
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXX---XXXXXXXX 1547
+ ED+++ F G P P VTW +D K L A+ + EN
Sbjct: 20785 IAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGK 20844
Query: 1548 YKCIAFNDHGEVETSCV-VGIQQKPVITISNEDIKQKH-KVGDEWLV--TAVIEGIPPPE 1603
Y N GE ++S V V + P + + ++ KH G L+ +I+G P
Sbjct: 20845 YILTIENGVGEPKSSTVSVKVLDTPA---ACQKLQVKHVSRGTVTLLWDPPLIDGGSP-- 20899
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTSS-VEVT-- 1659
+I Y + + +++ + + +S ++ +L + + A N G E T
Sbjct: 20900 IINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEP 20959
Query: 1660 LKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADV 1719
+K + P+ P + M++ ++ SV + W P DGG +T+Y +E+ W A +
Sbjct: 20960 VKAAEVPA-PIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTW-SHAGI 21017
Query: 1720 DRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXI 1779
+ E + +L E FRV A+N G S+ + PI +K + P +
Sbjct: 21018 SKTCEIE-VSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQV 21076
Query: 1780 D---NESVYITWFPSEKNGGSPIIDYKVE--IKQEGKKWKXXXXXXXXXARIQKLSINTT 1834
+V++ P K P I + + +E + + I+
Sbjct: 21077 TVRIGHNVHLE-LP-YKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHG 21134
Query: 1835 YQFRIYARNEI-GTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEPESN 1892
++ + N + ++P T IT+G PPS+P+ + E + SV L W PE N
Sbjct: 21135 GKYTVILDNAVCRIAVPIT---VITLG----PPSKPKGPIRFDEIKADSVILSWDVPEDN 21187
Query: 1893 GGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
GG IT Y IE + +W K+V + + N+ + E FR+ AEN GVS P
Sbjct: 21188 GGGEITCYSIEKRETSQTNW-KMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL 21246
Query: 1953 ESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM 2012
S + + +P PP P+ I V S+ + +W P +DGG+ + G+++ ++ +
Sbjct: 21247 VSSIIVAKHQFRIPGPPGKPV-IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSIL 21305
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
W +V ++ ++ L E Y R+YA N GLS P
Sbjct: 21306 WQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSP 21345
Score = 190 bits (463), Expect = 5e-47
Identities = 204/757 (26%), Positives = 301/757 (39%), Gaps = 73/757 (9%)
Query: 1349 KVENTDAG-IYKLRL--ENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWD 1402
KV AG IY+ R+ EN G + V +D PP I +I +S+++ W
Sbjct: 20233 KVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQ 20292
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEV- 1459
+P G S I Y+VE +++ W S N+T+TQ +I L NS Y FR +A N V
Sbjct: 20293 QPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFTISGLTQNSQYEFRVFARNAVG 20352
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKN---ITTEPNEDIELTCIFGGVPQPKVTWY 1516
IS+ SE I P ++ PL+ + ++L G P P + WY
Sbjct: 20353 SISNPSEVVGPITCIDS--YGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWY 20410
Query: 1517 RDGKKLKT-AKATYENRXXXXXXXXXXXXXXXYKCIAF---NDHGEVETSCVVGIQQKP- 1571
+D K+L+T A EN C N + V I KP
Sbjct: 20411 KDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMASASATIRVQILDKPG 20470
Query: 1572 -------VITISNEDI----KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
T++ E I + G + ++E V+W LE E
Sbjct: 20471 PPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMVSEHLE---ECI 20527
Query: 1621 ITTKEKTSVIRIKE--LKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
ITT T +I+ E + +KY I + SV V + P P P + + I
Sbjct: 20528 ITT---TKIIKGNEYIFRVRAVNKYGI--GEPLESDSV-VAKNAFVTPGPPGIPEVTK-I 20580
Query: 1679 SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCEY 1737
++ S+T+ W P+ DGG +++ Y +EK + + W KV + RD + L EN +Y
Sbjct: 20581 TKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQK-VTGLTENSDY 20639
Query: 1738 MFRVIAQNPVGFSEALESEPIVIKTALDV--PSXXXXXXXXXXIDNESVYITWFPSEKNG 1795
+RV A N G + SEP A D P S+ + W +G
Sbjct: 20640 QYRVCAVNAAG--QGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPVYDG 20697
Query: 1796 GSPIIDYKVEIKQ-EGKKWKXXXXXXXXXAR---IQKLSINTTYQFRIYARNEIGTSLPY 1851
GS + Y VEI+Q E ++W + L Y FR+ A N G P
Sbjct: 20698 GSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPI 20757
Query: 1852 TSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK--TVKG 1909
++ P Q ++ + + V L+ T + G + +I FK
Sbjct: 20758 EMNE----------PVQAKDILEAPEIDLDVALR-TSVIAKAGEDV-QVLIPFKGRPPPT 20805
Query: 1910 KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVP--- 1966
+W K GS + IEN + N G + T V K +TV
Sbjct: 20806 VTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKV 20865
Query: 1967 -SPPTA--PLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
P A L+++ V V W P DGG+P++ Y I RD TK W V +T
Sbjct: 20866 LDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSST 20925
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
F + DLSE + R+ A NEIG+ EP E+ EP K
Sbjct: 20926 -SFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVK 20961
Score = 189 bits (460), Expect = 1e-46
Identities = 204/900 (22%), Positives = 371/900 (41%), Gaps = 65/900 (7%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVK 1249
+E P I L + +++ A+ L V I +V W K + ++ D + + S
Sbjct: 18605 IEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFT 18664
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
L+I T D Y L + T + V V++ P V+ +K+ S VTL
Sbjct: 18665 M--LVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIR-EVKKDS-VTL 18720
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS--KSASLTIKKVENTDAGI---YKLRL 1362
+ P + + + I++K + T+ + + + + T ++EN G +++
Sbjct: 18721 SWEP---PLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLA 18777
Query: 1363 ENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEY 1419
N G A+ V + + P PPG+ ++++ ++ I W++PE+ G S I YVVE
Sbjct: 18778 SNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEM 18837
Query: 1420 QEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
Q + +W + + + +I L Y FR AVNE SD + + ++ +I
Sbjct: 18838 QTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQ-LGVPVIARDIEI 18896
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXX 1538
+ P+VE P + E +++ F G PQ V W +DG+ LK T + +
Sbjct: 18897 K-PSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSL 18955
Query: 1539 X---XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV 1595
Y+ N G + + + +P ++ + +
Sbjct: 18956 SIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRP-------GPPGPIRIDEVSCDSIT 19008
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS------VIRIKELKRSHSSKYTIEASN 1649
I PP + N + KE TT S I+I L ++ + A N
Sbjct: 19009 ISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAEN 19068
Query: 1650 TAGTSSV-EVTLKVYDKPSKPEGPVIMREI---SRESVTIEWKPPLDDGGLELTKYAIEK 1705
G SS E + V + P P GP ++ ++ ++ + W+ P++DGG + Y +E
Sbjct: 19069 RYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEY 19128
Query: 1706 HEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTAL 1764
E + W K + + L+E Y +RV A+N G + +S EP+ +
Sbjct: 19129 KERSSILWSKANKILIADTQVKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPC 19188
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGKKWK-XXXXXXX 1821
D P I +SV + W +GG+ I Y VE ++ +G+ K
Sbjct: 19189 DPPG----QPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQE 19244
Query: 1822 XXARIQKLSINTTYQFRIYARNEI-GTSLPYTSDDKITIGKTLTPPSQPRNFVVSE--ST 1878
+ +L+ + Y+FR++ARN S P S I + + PP + +
Sbjct: 19245 TYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVV 19304
Query: 1879 SRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKE---KDE 1935
LK + P+ ++ + ++ ++ T+I+ S H + +K+ +D
Sbjct: 19305 KAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEII----STDNHTLLTVKDCIRRDT 19360
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
+ ++ +N G T S +V K P PP PLEI + + SWG P+ DGG
Sbjct: 19361 GQYVLTLKNVAG----TRSVAVNC-KVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGG 19415
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
A + Y+ R+ + W + + ++ + L + + Y+ R+ N+ G+ EPLES
Sbjct: 19416 ADIDYYHRKKRETSHLAW-TICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLES 19474
Score = 186 bits (454), Expect = 6e-46
Identities = 168/699 (24%), Positives = 290/699 (41%), Gaps = 43/699 (6%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKT 1436
KP PP P +++I SS+ + W +P G I Y+VE +++ EW I KT
Sbjct: 16340 KPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVNVGEWTMCTPPTGINKT 16399
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITT 1493
++ L Y FR A+N+ + + ++ +I E K+++P ++ L K I
Sbjct: 16400 NIEVEKLLEKHEYNFRICAINKAGVGEHADVPG--PIIVEEKLEAPDIDLDLELRKIINI 16457
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCI 1551
+ L G P P+V W + +++ A + Y
Sbjct: 16458 RAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLT 16517
Query: 1552 AFNDHGEVETSCVVGI--QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
N G V + P + + +I K V W + G I K
Sbjct: 16518 LENSSGTKSAFVTVRVLDTPSPPVNLKVTEI-TKDSVSITWEPPLLDGGSKIKNYIVEKR 16576
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT---LKVYDKP 1666
+T K S +I +L+ S + + A N G T +KV + P
Sbjct: 16577 -EATRKSYAAVVTNCHKNS-WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVP 16634
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
+P G + + +++R SV++ W P DGG ++ +Y +E + +W + A V + ++
Sbjct: 16635 -QPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARV-KSLQA- 16691
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVY 1785
I L + EY+FRV+A N G S+ + PIV K + P + +
Sbjct: 16692 VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLK 16751
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXA-RIQKLSINTTY-----QFRI 1839
+ S + P I + ++G K + + LSI T+ Q+ I
Sbjct: 16752 MEVPISGR--PKPTITW----TKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16805
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
N +G S + +T+ K PP P F + ++ S+TL W P GG ITN
Sbjct: 16806 TVANVVGQKT--ASIEIVTLDKP-DPPKGPVKF--DDVSAESITLSWNPPLYTGGCQITN 16860
Query: 1900 YIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
YI++ + W + TV + + + +K E FRI AEN G S ES +
Sbjct: 16861 YIVQKRDTTTTVWDVVSATVARTTLK--VTKLKTGTEYQFRIFAENRYGQSFALESDPIV 16918
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
+ P PP P + ++V+ W P +GG+P++GY++ ++ +W +V K
Sbjct: 16919 AQYPYKEPGPPGTPFATAISKDSMVI-QWHEPVNNGGSPVIGYHLERKERNSILWTKVNK 16977
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
++ +F ++L E Y R+YA N +G+ + ++ E
Sbjct: 16978 TIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSE 17016
Score = 186 bits (453), Expect = 8e-46
Identities = 173/698 (24%), Positives = 291/698 (41%), Gaps = 41/698 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK---NITKT 1436
KP PPG P +L+ SSI+I W++P G S I Y+VE + EW V + T
Sbjct: 15258 KPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKAT 15317
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITT 1493
+I L N Y+ R YA+N + + + K E ++ P +E K +T
Sbjct: 15318 SYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKA--EDRMLPPEIELDADLRKVVTI 15375
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRD-GKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCI 1551
+ L G P P+V W RD G+ L K + + + Y
Sbjct: 15376 RACCTLRLFVPIKGRPDPEVKWARDHGESLDKASIESASSYTLLIVGNVNRFDSGKYILT 15435
Query: 1552 AFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT---AVIEGIPPPEVIWYK 1608
N G V + P +D+K K +T +++G ++ Y
Sbjct: 15436 VENSSGSKSAFVNVRVLDTPG---PPQDLKVKEVTKTSVTLTWDPPLLDG--GSKIKNYI 15490
Query: 1609 NGNKLENDKEYNI--TTKEKTSVIRIKELKRSHSSKYTIEASNTAGT---SSVEVTLKVY 1663
+ K Y+ T KTS ++ +L+ S + + A N G + ++K
Sbjct: 15491 VEKRESTRKAYSTVATNCHKTSW-KVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKAS 15549
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
++P P G + + +++R SV++ W+ P DGG + Y +E +++W A V V
Sbjct: 15550 ERPLPP-GKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVK--V 15606
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
I L + EY FRV AQN G S+ + S P++ K + P+ + E
Sbjct: 15607 TEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGE 15666
Query: 1783 SVYITWFPSEKNGGSPIIDYK--VEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIY 1840
+ + P + +K V +KQ + I+ + +
Sbjct: 15667 DLKVD-VPFIGRPTPAVTWHKDNVPLKQTTRV-NAESTENNSLLTIKDACREDVGHYVVK 15724
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
N G ++ + I + K PP+ P + E T+ S+TL W P+ +GGS I NY
Sbjct: 15725 LTNSAGEAIETLN--VIVLDKP-GPPTGPVK--MDEVTADSITLSWGPPKYDGGSSINNY 15779
Query: 1901 IIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
I+E + +W + TV + + C +K E FRI+AEN G S S+
Sbjct: 15780 IVEKRDTSTTTWQIVSATVARTTIKAC--RLKTGCEYQFRIAAENRYGKSTYLNSEPTVA 15837
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
+ VP PP P+ + + + + W P DGG+ ++GY++ ++ +W+++ K
Sbjct: 15838 QYPFKVPGPPGTPV-VTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKT 15896
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
+ KF L E Y R+ A N +G+ +P + E
Sbjct: 15897 PIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSE 15934
Score = 184 bits (449), Expect = 2e-45
Identities = 168/697 (24%), Positives = 286/697 (41%), Gaps = 35/697 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK---NITKT 1436
KP PP +I++ +SI + W +P G S I+ YVVE + D EW V + T
Sbjct: 17422 KPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVT 17481
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE---KPLKNITT 1493
+ I L + Y+ R A+N+V + +A+ K E K+++P ++ + K I
Sbjct: 17482 RFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVK--PEDKLEAPELDLDSELRKGIVV 17539
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKC 1550
+ F G P P++TW R+ + T K E N Y
Sbjct: 17540 RAGGSARIHIPFKGRPMPEITWSREEGEF-TDKVQIEKGVNYTQLSIDNCDRNDAGKYIL 17598
Query: 1551 IAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLV--TAVIEGIPPPEVIWYK 1608
N G V + P N +K+ K +LV +I+G +V Y
Sbjct: 17599 KLENSSGSKSAFVTVKVLDTPGPP-QNLAVKEVRK-DSAFLVWEPPIIDG--GAKVKNYV 17654
Query: 1609 NGNKLENDKEY-NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD--K 1665
+ K Y N+++K + +++ L + + A N G T+ +
Sbjct: 17655 IDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAE 17714
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P P G V + ++S+ S ++ W+ P DGG + Y +E +W VA+ V
Sbjct: 17715 PPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAE--SKVCN 17772
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEA-LESEPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
+ L+ EY FRV A N G S+ + P++ K PS E +
Sbjct: 17773 AVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDL 17832
Query: 1785 YITWFPSEKNGGSPIIDYKV-EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
I P I K E ++ + I++ + + ++ + A N
Sbjct: 17833 KIE-IPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATN 17891
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
GT+ T + + + + PP P F E ++ V + W P GG I+NYI+E
Sbjct: 17892 SAGTA---TENLSVIVLEKPGPPVGPVRF--DEVSADFVVISWEPPAYTGGCQISNYIVE 17946
Query: 1904 FKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
+ +W + TV + + I +K E FRI AEN G S P +S++V ++
Sbjct: 17947 KRDTTTTTWHMVSATVARTTIK--ITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYP 18004
Query: 1963 ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
P PP P + + + ++ W P DGG ++GY++ ++ +W+++ K +
Sbjct: 18005 FKEPGPPGTPF-VTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKTPIQ 18063
Query: 2023 TLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPF 2059
KF L E Y ++ A N +G+ +P + E F
Sbjct: 18064 DTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECF 18100
Score = 184 bits (449), Expect = 2e-45
Identities = 215/966 (22%), Positives = 385/966 (39%), Gaps = 81/966 (8%)
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLT 1217
G+K ++ ++ EYS + ++ + +E P + L + + + A L
Sbjct: 22913 GQKYSFRVAAVNVKGMSEYSESI--AEIEPVERIEIPDLELADDLKKTVTIRAGASLRLM 22970
Query: 1218 VEIPDETLDV-TWYKK------KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
V + V TW K+ +++I+ TE ++L LI+ K D +YT
Sbjct: 22971 VSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL--------LIVDKVNRYDAGKYTIEA 23022
Query: 1271 LD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
+ K + + V+V + P ++K S ++ + ++ P + +N+ I+
Sbjct: 23023 ENQSGKKSATVLVKVYDTPGPCPSV----KVKEVSRDSVTITWE-IPTIDGGAPINNYIV 23077
Query: 1329 KKCKHTKPSIDSKSA--SLTIKKVENTDAGI---YKLRLENNCG---HADVEMNVTILDK 1380
+K + + + + S T+ ++ G +++ EN G + V + +
Sbjct: 23078 EKREAAMRAFKTVTTKCSKTLYRISGLVEGTMHYFRVLPENIYGIGEPCETSDAVLVSEV 23137
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKT--QT 1438
P P K ++++ S++ + W++P G S + YV+E + T W+ V + T +
Sbjct: 23138 PLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEH 23197
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE---KPLKNITTEP 1495
++ +L Y FR A NE +S+ ET +++ ++ PT++ P K I
Sbjct: 23198 TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV-TVQDLRV-LPTIDLSTMPQKTIHVPA 23255
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCI 1551
+EL G P P +W+ G KL+ ++ T+ Y
Sbjct: 23256 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 23315
Query: 1552 AFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK--N 1609
N G + V I KP I DE T++ PPE+ +
Sbjct: 23316 LKNVTGTTSETIKVIILDKPGPPTGPIKI-------DEIDATSITISWEPPELDGGAPLS 23368
Query: 1610 GNKLENDKEYN-----ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD 1664
G +E + ++ S + L + + + A+N G S + +
Sbjct: 23369 GYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIEC 23428
Query: 1665 K-----PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADV 1719
+ P PE I ++SR+ +T+ W PP DDGG ++T Y +E+ E +RW++V V
Sbjct: 23429 RSSIRIPGPPETLQIF-DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKV 23487
Query: 1720 DRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXX 1778
+ Y L E EY RV A N G + + S+PIV + P
Sbjct: 23488 PVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPI-APPGKPQNPRVTD 23546
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEI-KQEGKKWKXXXXXXXXXAR--IQKLSINTTY 1835
SV + W E GGS + Y +E+ K + +W + L Y
Sbjct: 23547 TTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEY 23606
Query: 1836 QFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESNG 1893
+FR+ A N G P + + + L P + E + ++ T P
Sbjct: 23607 RFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGK 23666
Query: 1894 GSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
PI + E + + ++ ++ + E I+ D + + EN G +
Sbjct: 23667 PFPICKWTKEGQDISKRA---MIATSETHTELVIKEADRGDSGTYDLVLENKCG----KK 23719
Query: 1954 SQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMW 2013
+ +++ + P+ P PLE + V SW P DGGA +LGY + R+V K W
Sbjct: 23720 AVYIKVRVIGS-PNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAW 23778
Query: 2014 MEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEP 2073
+ V ++ L EN Y R+ A N+ G+S+PL+S+EP V P + E P
Sbjct: 23779 YTIDS-RVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEP--VTPKTPLNPPEPP 23835
Query: 2074 GEQTEV 2079
EV
Sbjct: 23836 SNPPEV 23841
Score = 184 bits (448), Expect = 3e-45
Identities = 168/704 (23%), Positives = 281/704 (39%), Gaps = 46/704 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP P + + + ++ W +P + G S I+ YVVE Q+ T +W + I +
Sbjct: 11307 PGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCA 11366
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN---ITTE 1494
+ L + YRFR A N V + E E VI + + P VE + IT
Sbjct: 11367 FRVPGLIEGNEYRFRIKAANIVGEGEPRELAE--SVIAKDILHPPEVELDVTCRDVITVR 11424
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT--YEN--RXXXXXXXXXXXXXXXYKC 1550
+ I + G P+P +TW ++GK L K ++ R Y
Sbjct: 11425 VGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYII 11484
Query: 1551 IAFNDHGEVETSCVVGIQQKPVITISNEDIKQ--KHKVGDEWLVTAVIEGIPPPEVIWYK 1608
A N G + S +V + +P N + K W G E+ +
Sbjct: 11485 SAKNSSGHAQGSAIVNVLDRPG-PCQNLKVTNVTKENCTISWENPLDNGG---SEITNFI 11540
Query: 1609 NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG------TSSVEVTLKV 1662
+ N K ++I + T + L ++ + + A N G T + + +
Sbjct: 11541 VEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINP 11600
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
D+P +PE + + + + V ++W+ P DGG Y +E+ ++ W +V
Sbjct: 11601 IDRPGEPEN-LHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIK 11659
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
Y + + EN Y FRV +N G S+ +++E +V+K L P +
Sbjct: 11660 ETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAG 11719
Query: 1783 SVYITWFPSEKNGGSPII----DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFR 1838
I + P + D + K + K + ++
Sbjct: 11720 DT-IRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 11778
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPIT 1898
+ A N G+ + Y + + L P RN + + +S T+ W PE +GG I
Sbjct: 11779 VTATNTAGSFVAYATVN------VLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQ 11832
Query: 1899 NYIIEFKTVKGKSWTK----IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
NYI+E K W+ ++T G +V + E +E IFR+ AEN +G PTES
Sbjct: 11833 NYILEKCETKRMVWSTYSATVLTPGTTV-----TRLIEGNEYIFRVRAENKIGTGPPTES 11887
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
+ V + P P P E+ V + W PE+DGG + GY + ++ T W+
Sbjct: 11888 KPVIAKTKYDKPGRPDPP-EVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWV 11946
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
V K + + +++L +H Y R+ A NEIG+ EP P
Sbjct: 11947 PVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRP 11990
Score = 184 bits (448), Expect = 3e-45
Identities = 107/367 (29%), Positives = 174/367 (47%), Gaps = 6/367 (1%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G+ + A+++G P P V W+K+G ++E IT ++ + +++ R H YT
Sbjct: 21474 KSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITNVLGSTSLFVRDATRDHRGVYT 21533
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+EA N +G++ E+ +KV D P K GP+ I+ E +T+ W PL+DG +T Y IE
Sbjct: 21534 VEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHYIIE 21593
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTAL 1764
K E W + D + ++Y KL EY FRV A N G L+S+P+V +
Sbjct: 21594 KRETSRLAWALIED-KCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQY 21652
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKW-KXXXXXXXX 1822
VP I S+ +TW E +GGS I Y +E ++ + +W K
Sbjct: 21653 TVPD-APGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPIS 21711
Query: 1823 XAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSR 1880
R + L+ Y+F + A N G I + + PP P V++++
Sbjct: 21712 ETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKT 21771
Query: 1881 SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
+V+L+W++P +GG I YIIE W K+ + + +++ +E FR+
Sbjct: 21772 TVSLEWSKPVFDGGMEIIGYIIEMCKTDLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRV 21831
Query: 1941 SAENTVG 1947
SA N G
Sbjct: 21832 SAINGAG 21838
Score = 184 bits (447), Expect = 4e-45
Identities = 247/1098 (22%), Positives = 447/1098 (40%), Gaps = 107/1098 (9%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
GI F + Q V EG C L + + + W ++ + ++ E H
Sbjct: 5074 GIRLKFMSPLEDQTVKEGETATFVCEL-SHEKMHVVWFKNDAKLHTSRTVLISSEGKTHK 5132
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ +E T ++ + L ++K E +P ++ V + E
Sbjct: 5133 L----------EMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKDE 5182
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKA 807
+ L +V + + W K+ + + P K+DG I +K +KD+G Y
Sbjct: 5183 -ITLKCEV--SKDVPVKWFKDGEEIVPSPKYSIKADG-LRRILKIKKADLKDKGEYVCDC 5238
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
G +T A +TVE E E PL+ E+ V E ++ P W
Sbjct: 5239 ----GTDKTKANVTVEARLIE-VEKPLY---GVEVFVGETAHFEIELS---EPDVHGQWK 5287
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ ++ S DG+ L++ N + +G+ A+N+ KS+ A + +
Sbjct: 5288 LKGQPLTASPDCEIIEDGKKHILILHNCQLGM-TGEVSFQAANA--KSA--ANLKVKELP 5342
Query: 928 VTFVKHLQ--KSYETEEGKTVILECQTSHTVST-KWYHNKKEISGMDHREIIQEGRXXXX 984
+ F+ L K +E +E K EC+ S T +W +EI+G D E+I++G
Sbjct: 5343 LIFITPLSDVKVFEKDEAK---FECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSM 5399
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D +D+ TS L+++ +F+ L+D KEK+ A+ VE++ +
Sbjct: 5400 VIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELSHDN 5459
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
V W ++ + + ++ + G + ++ S+ D + S A++TV+E
Sbjct: 5460 IRVKWFKNDQRLHTTRS-VSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLE 5518
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P +LQ+ + ++ + E++K DA V+WFKDG EI+ S + + DGKK+ L
Sbjct: 5519 GDPYFTGKLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKTDGKKRMLI 5578
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G+Y+C+ G K + L +E+ I L ++ T + T EI ++
Sbjct: 5579 LKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFET-EISEDD 5637
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + T + + K +L++ C D + KS+ L+V+
Sbjct: 5638 IHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVK-- 5695
Query: 1285 EFPPKIVDYER---EYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
P+++ R + + G T + Y+ P EW + K ++ P +
Sbjct: 5696 ---PRVIGLLRPLKDVTVTAGETATFDCELSYEDIPV---EWYLKGKKLEPSDKVVPRSE 5749
Query: 1340 SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINI 1399
K +LT++ V+ DAG +L ++ HA N+ + + P KP LE
Sbjct: 5750 GKVHTLTLRDVKLEDAGEVQLTAKDFKTHA----NLFVKEPPVEFTKP--LE-------- 5795
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
D+ G + ++ V +E +W KN T+ S + + + R R +++
Sbjct: 5796 --DQTVEEGATAVLECEVS-RENAKVKWF--KNGTEILKS-KKYEIVADGRVRKLVIHDC 5849
Query: 1460 ---DISDASETTEYYKVIKETKIQSPTVE--KPLKNITTEPNEDIELTCIFGGVPQPKVT 1514
DI + + +K + P VE +PL ++ E C KV
Sbjct: 5850 TPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSR-ENAKVK 5908
Query: 1515 WYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV-GIQQKPVI 1573
W++DG ++K K Y+ KC+ +D E E SC V + ++
Sbjct: 5909 WFKDGAEIKKGK-KYD-----IISKGAVRILVINKCL-LDD--EAEYSCEVRTARTSGML 5959
Query: 1574 TISNED-IKQKHKVGDEWLVTAVIEGI-----PPPEVIWYKNGNKLENDKEYNITTKEKT 1627
T+ E+ + K+ E T I+ + P EVIWYK ++ Y I T+ +
Sbjct: 5960 TVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRK 6019
Query: 1628 SVIRIKELKRSHSSKYT--IEASNTAGTSSV-EVTLKVYDKPS-----KPEGPVIMREIS 1679
++ I+ + Y + +S T G V E+ + KP + E + IS
Sbjct: 6020 RILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSIS 6079
Query: 1680 RESVTIEWKPPLDDGGLE 1697
+ES ++WK DD LE
Sbjct: 6080 KESFPVQWK--RDDKTLE 6095
Score = 183 bits (446), Expect = 5e-45
Identities = 178/727 (24%), Positives = 290/727 (39%), Gaps = 68/727 (9%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV----KNITKT 1436
P PP P + + SSI++ W P G S I Y+VE QE TT+W V K IT
Sbjct: 9208 PGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTC 9267
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEP 1495
+ + NLK YRFR AVNE S+ S+TT + ++ ++ + +
Sbjct: 9268 ECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKA 9327
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------------ATYENRXXXXXXXXXXX 1543
I + + G P PK +W DGK K K T EN
Sbjct: 9328 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRS 9387
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPP 1602
Y A N G+ +C V + P +D+K G L + +
Sbjct: 9388 HTGKYSITAKNKAGQKTANCRVKVMDVPG---PPKDLKVSDITRGSCRLSWKMPDDDGGD 9444
Query: 1603 EVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
+ Y + + K + + ++ + +L + + A N G T++
Sbjct: 9445 RIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQ 9504
Query: 1662 ---VYDKPSKPEGPVIMRE--ISRESVTIEWKPPLDDGGLELTKYAIE--KHEPDNNR-- 1712
D P+ P+ ++ I++ +V + WKPP +DGG +T Y +E +P +
Sbjct: 9505 RTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKE 9564
Query: 1713 -WIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXX 1771
W + D + + ++ L E EY FRV A N G S+ + D+P
Sbjct: 9565 AWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSID 9624
Query: 1772 XXXXXXXIDNESVYI------------TWF---PSEKNGGSPIIDYKVEIKQEGKKWKXX 1816
+ +V I TWF P + + P++ Y + +
Sbjct: 9625 LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVL-YDTHVNK-------L 9676
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE 1876
I + + T + I A N +GT+ + + ++ + PP P F E
Sbjct: 9677 VVDDTCTLVIPQSRRSDTGLYTITAVNNLGTA---SKEMRLNVLGRPGPPVGPIKF---E 9730
Query: 1877 STSRS-VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
S S +TL W P+ +GGS ITNY+IE + K+W + + + I + E E
Sbjct: 9731 SVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKEC-TYTIPKLLEGHE 9789
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
+FRI A+N G+ P +S+ +VP P P + V N + +W PE+DGG
Sbjct: 9790 YVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPT-VSSVTRNSMTVNWEEPEYDGG 9848
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTL----KFNIRDLSENHTYMIRIYARNEIGLSE 2051
+P+ GY + ++D T W V + + + + + L E Y R+YA N G+
Sbjct: 9849 SPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGP 9908
Query: 2052 PLESDEP 2058
+P
Sbjct: 9909 ASLPSDP 9915
Score = 181 bits (440), Expect = 3e-44
Identities = 176/746 (23%), Positives = 300/746 (40%), Gaps = 44/746 (5%)
Query: 795 KKVKDEGVYTLKA---ENSEGIAETSAV-ITVEEPTEENAEP----PLFINRFQEITVKE 846
+K KDE ++ K E + +AE + I +P + P P R Q TV +
Sbjct: 1986 RKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQ 2045
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENI-ELVITNVDSEIDSGDYK 905
RV P P WY+N I S+ I + +N+ ELVI +V +E DS
Sbjct: 2046 GSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAE-DSASIM 2104
Query: 906 CVASNSAGKSSHGARVTIDVEK-VTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHN 963
A N AG++S A + + ++ +TF + LQ E+ EC+TS V KWY +
Sbjct: 2105 VKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKD 2164
Query: 964 KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE---TSTMLVVKETIPEFI 1020
E+ D + + + D C++ + E T+ L+V+ + EF+
Sbjct: 2165 GMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFV 2224
Query: 1021 RKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTS 1080
++LQD EV E LE ++ E + W + +K KY R + L +++ +
Sbjct: 2225 KELQDIEVPESYSGELECIVSPENIEGKWYHNDVELK-SNGKYTITSRRGRQNLTVKDVT 2283
Query: 1081 VHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWF 1140
D+GEYS ++ + T ++ + P I+ L +QKV +G+ E++++ W
Sbjct: 2284 KEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWM 2343
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL 1200
KDG E+Q S+ + + ID + L I D +DAG YS + + V S++
Sbjct: 2344 KDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVIT 2403
Query: 1201 RLPEFILVPANTDAYL--TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
L + + V T A L V +PD T V WY I+ ++ I K+ L+I +
Sbjct: 2404 PLKD-VNVIEGTKAVLECKVSVPDVT-SVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRT 2461
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
D+ Y ++ ++ L VE + KI+ R+ +V V+ + +
Sbjct: 2462 HASDEGPYKLIVGRVETNCNLSVEKI----KIIRGLRDLTCTETQNVVFEVEL-SHSGID 2516
Query: 1319 DEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL 1378
W K IK K K LT+ + D G Y N + + +
Sbjct: 2517 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAI 2576
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT 1438
KP + E + P++ G EW+
Sbjct: 2577 SKPLT--DQTVAESQEAVFECEVANPDSKG-----------------EWLRDGKHLPLTN 2617
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
+I++ R A DI + + K + K+++ ++K LKN+T +D
Sbjct: 2618 NIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2677
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKT 1524
T V W ++G L++
Sbjct: 2678 AVFTVELTHPNVKGVQWIKNGVVLES 2703
Score = 179 bits (435), Expect = 1e-43
Identities = 155/561 (27%), Positives = 248/561 (44%), Gaps = 26/561 (4%)
Query: 804 TLKAENSEGIAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
T+K E E S VI ++ T + P + + V E ++L +V+
Sbjct: 2278 TVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLES 2337
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
V + W ++ + + PS+ + D ++ L+I ++ E D+G+Y + G S+ G
Sbjct: 2338 VEGV-WMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKE-DAGNYSFTIP-ALGLSTSGRV 2394
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQE 978
V+ +T +K + EG +LEC+ S S KWY N ++I D + I +
Sbjct: 2395 SVYSVDVITPLKDVN----VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVK 2450
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
G D G K IV ET+ L V++ + IR L+D E + EV
Sbjct: 2451 GTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI--KIIRGLRDLTCTETQNVVFEV 2508
Query: 1039 EINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA 1098
E++ DV+W + IKP +KY E G I KL + N DEG+Y+ + +
Sbjct: 2509 ELSHSGIDVLWNFKDKEIKPS-SKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSG 2567
Query: 1099 EVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDG 1158
++TV I L +Q V + +A FE E+ D+ W +DG + +N+I+ DG
Sbjct: 2568 KLTVAG--GAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDG 2625
Query: 1159 KKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
K++L I LDD GEY+ +V SK +A L VE I TL+ + V DA TV
Sbjct: 2626 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLK---NLTVTETQDAVFTV 2682
Query: 1219 EIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
E+ + V W K V+E EK+ + +L I+ C D+ Y L ++
Sbjct: 2683 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASA 2742
Query: 1278 KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
+L VE V KI+ ++ + V V P +W S IK +
Sbjct: 2743 RLHVETV----KIIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHRLV 2797
Query: 1338 IDSKSASLTIKKVENTDAGIY 1358
+ K L ++ + +DAG Y
Sbjct: 2798 SERKVHKLMLQNISPSDAGEY 2818
Score = 179 bits (435), Expect = 1e-43
Identities = 153/697 (21%), Positives = 291/697 (41%), Gaps = 36/697 (5%)
Query: 1382 SPPGKPNILEIDSSS---INICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
+PPG P ++++ +S +++ W +P G II Y++E + D +W ++ + KT
Sbjct: 21755 NPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKTDLGDWHKVNAEACVKT 21814
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI-TTEP 1495
+ ++ +L+ Y+FR A+N D+ E T K + ++ K
Sbjct: 21815 RYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRA 21874
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAF 1553
I L + G P P W + L T ++ Y
Sbjct: 21875 GASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVE 21934
Query: 1554 NDHGEVETSCVVGIQQKPVIT--ISNEDIKQKHKVGDEWLV--TAVIEGIPPPEVIWYKN 1609
N+ G + V + P I+ +D+ + G L+ +++G + Y
Sbjct: 21935 NNSGSKSITFTVKVLDTPGPPGPITFKDVTR----GSATLMWDAPLLDG--GARIHHYVV 21988
Query: 1610 GNKLENDKEYNITTKEKT-SVIRIKELKRSHSSKYTIEASNTAGTSS---VEVTLKVYDK 1665
+ + + + + +++ T + ++ +L + + A N G + + ++
Sbjct: 21989 EKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQ 22048
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P+ P ++ + S+ S + W P DGG +T Y +E + ++ W++ + T
Sbjct: 22049 PAPPRRLDVV-DTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDLWVEAGHTKQ--LT 22105
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
+ +++L E EY FRV A+N G+SE E+ ++IK P+ I ++
Sbjct: 22106 FTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAG 22165
Query: 1785 YITWFPSEKNGG-SPIIDYKVEIKQ--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+G +P + +K+E + E + ++ + ++ +
Sbjct: 22166 SPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTL 22225
Query: 1842 RNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
N G S + IG+ P + P VS ++ S L W EP+ GG+ ITNYI
Sbjct: 22226 ENTAGVKT--FSVTVVVIGRP-GPVTGP--IEVSSVSAESCVLSWGEPKDGGGTEITNYI 22280
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
+E + +W ++V + + ++ + E FR+S+EN GVS P ES + E
Sbjct: 22281 VEKRESGTTAW-QLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEH 22339
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
PS PT P E+ V +N + W P DGG+ ++GY + ++ +W++ KV
Sbjct: 22340 PFVPPSAPTRP-EVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPC 22398
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ + L E Y R YA N G+S+ E+ P
Sbjct: 22399 LECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRP 22435
Score = 177 bits (431), Expect = 4e-43
Identities = 155/678 (22%), Positives = 278/678 (41%), Gaps = 27/678 (3%)
Query: 712 AVNREGEASLPIVLKIK---TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
A+ EG+ ++P K + E P++ E ++S V QG +VVG P P W
Sbjct: 2006 ALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEW 2065
Query: 769 CKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
KN ++ + D +++ +D +KA N G + A + V+
Sbjct: 2066 YKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA- 2124
Query: 826 TEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
+ F Q++ KEK T+ T P + WY++ + + + D
Sbjct: 2125 ----KQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDR 2180
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+ L I +D+ D+ DY CV + A++ ++ V FVK LQ E E +
Sbjct: 2181 KVHFLSILTIDTS-DAEDYSCVLVEDENVKT-TAKLIVEGAVVEFVKELQ-DIEVPESYS 2237
Query: 946 VILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ 1004
LEC S + KWYHN E+ I D G ++ +
Sbjct: 2238 GELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK 2297
Query: 1005 ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY- 1063
+T+ L +K ++ L D +V E D+ LEV+++ E+ + VW +DG+ ++P +
Sbjct: 2298 KTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHI 2357
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
+K+ H+ L I + + D G YS + + V ++IT L++ V +G K
Sbjct: 2358 VIDKQSHM--LLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTK 2415
Query: 1124 ATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
A E +++ D V+W+ + +I+ + +Q + G KQ+L I D G Y VG
Sbjct: 2416 AVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGR 2475
Query: 1183 SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKF 1242
+ L+VE+ I LR + + VE+ +DV W K I+ + K+
Sbjct: 2476 VETNCNLSVEKIKIIRGLR---DLTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKY 2532
Query: 1243 TLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
+ + K L + +DD+ +YT + ++ KL V + D +
Sbjct: 2533 KIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTD----QTVAES 2588
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
+ + A P EW+ + K + + + D L I + D G Y ++
Sbjct: 2589 QEAVFECEV-ANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKV 2647
Query: 1363 ENNCGHADVEMNVTILDK 1380
+ A +++ + K
Sbjct: 2648 ATSKTSAKLKVEAVKIKK 2665
Score = 177 bits (431), Expect = 4e-43
Identities = 173/747 (23%), Positives = 309/747 (41%), Gaps = 47/747 (6%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
SK Q V E + + EC VA P+ WL G+ + NI ESD H ++
Sbjct: 2577 SKPLTDQTVAESQEAVFECE-VANPDSKGEWLRDGKHLPLTNNIRS--ESDGHKRRLIIA 2633
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
T + E TY V + + V KIK + LK++ V + + + +
Sbjct: 2634 ATKLDDIGEYTYKVATSKTSAKLKVEAV-KIK----------KTLKNLTVTETQDAVFTV 2682
Query: 757 QVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
++ + W KN +++ G +S+ I K + DE VY + G
Sbjct: 2683 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI-KNCAIVDESVYGFRL----GR 2737
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
SA + VE I + +++T E T+ V+ + VP + W+ + I
Sbjct: 2738 LGASARLHVETVK--------IIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEI 2788
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
PS+ + + +L++ N+ S D+G+Y V G+ A++ ++ +T
Sbjct: 2789 KPSDKHRLVSERKVHKLMLQNI-SPSDAGEYTAVV----GQLECKAKLFVETLHIT---K 2840
Query: 934 LQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXX 992
K+ E E KT EC+ SH V + W N EI + +I+ +G+
Sbjct: 2841 TMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE 2900
Query: 993 DVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERD 1052
D + + + S L V + L+D +EKD EV +N E W ++
Sbjct: 2901 DSAEYTFVCGNDQVSATLTVTPIM--ITSMLKDINAEEKDTITFEVTVNYEGISYKWLKN 2958
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR 1112
G IK +K + L IRN D +Y+ + + TA + V E
Sbjct: 2959 GVEIK-STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKH 3017
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+++ KV + +A FE E+++ D V+W KD E+Q ++ I++ + +L I + D
Sbjct: 3018 IKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3077
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
AG+Y+ G + TA L VE + + + + V A + E+ ++ +D WYK
Sbjct: 3078 AGKYTVVAGGNVSTAKLFVEGRDVRIR-SIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3136
Query: 1233 KSVI--EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
I + E+ + + + + I + + D EYT V +S+ L V E PP++
Sbjct: 3137 GIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPE-PPQV 3195
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
+ + ++ G PQP W +++ K D + +L + +
Sbjct: 3196 LQELQPVTVQSGKPARFCAMISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEA 3255
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTI 1377
DA +Y +N+ G A ++++
Sbjct: 3256 FPEDAAVYTCEAKNDYGVATTSASLSV 3282
Score = 177 bits (431), Expect = 4e-43
Identities = 212/908 (23%), Positives = 369/908 (40%), Gaps = 68/908 (7%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTW------YKKKSVIEDTEKFTLIS 1246
P L ++V A + V I +VTW K ++ IE+TE FTL
Sbjct: 14277 PDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTL-- 14334
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSD 1304
LII +C D ++ + + K + + V V++ P +++ R I + S
Sbjct: 14335 ------LIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNL-RPTDITKDS- 14386
Query: 1305 VTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL--TIKKVENTDAG---IYK 1359
VTL D P + + + I++K + T+ S + + KV G ++
Sbjct: 14387 VTLHWD---LPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFR 14443
Query: 1360 LRLENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
+ EN G + V + PSPP NI++I S++++ W +P++ G S I YV
Sbjct: 14444 VMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYV 14503
Query: 1417 VEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+E Q + +W + + + ++NL Y F+ AVN S E+ ++KE
Sbjct: 14504 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPV--IVKE 14561
Query: 1477 TKIQSPTVEKPL--KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRX 1533
+ + + K + + ++I++ G P+P VTW + + LK T + +E
Sbjct: 14562 QTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTA 14621
Query: 1534 XXXXXXX---XXXXXXXYKCIAFN---DHGEVETSCVVGIQQKPVITISNEDIKQKHKVG 1587
Y A N + G+V T V I P I +++ V
Sbjct: 14622 TSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDF-VT 14680
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
W G+P + + ++ + T + + L ++ ++A
Sbjct: 14681 FSWDPPENDGGVPISNYV--VEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKA 14738
Query: 1648 SNTAG-----TSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYA 1702
N G TS+ V + P P P + ++++S+TI W PL DGG + Y
Sbjct: 14739 QNRYGVGPGITSAWIVANYPFKVPGPPGTPQV-TAVTKDSMTISWHEPLSDGGSPILGYH 14797
Query: 1703 IEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIK 1761
+E+ E + W V+ + L + Y FRVIA+N G S+ + SEP++
Sbjct: 14798 VERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLAL 14857
Query: 1762 TALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGKKWKXXXXX 1819
+D P I +V + W E GG I Y VE + G+ K
Sbjct: 14858 DPIDPPG----KPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSN 14913
Query: 1820 XXXXA-RIQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKTLTPPSQPRNFVVSES 1877
+ L+ + Y+FR+ A+N G S P D IT + P + ++
Sbjct: 14914 ILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDT 14973
Query: 1878 TSRSVTLKW-TEPESNGGSPIT-NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
+ E + +G P T + + K ++G + +I S + ++ +D
Sbjct: 14974 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN-LVNKDSTRRDS 15032
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
+ ++A N G + + V L++ P PP PL + V S + SW P DGG
Sbjct: 15033 GAYTLTATNPGGFAKHIFNVKV-LDR----PGPPEGPLAVTEVTSEKCVLSWFPPLDDGG 15087
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
A + Y + R+ ++ W V +V K + L + + Y+ R+ A N+ G+ EPLES
Sbjct: 15088 AKIDHYIVQKRETSRLAWTNVAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLES 15146
Query: 2056 DEPFKVIP 2063
+ V P
Sbjct: 15147 EPVLAVNP 15154
Score = 175 bits (426), Expect = 1e-42
Identities = 240/1060 (22%), Positives = 406/1060 (38%), Gaps = 87/1060 (8%)
Query: 645 VDEGSDILLECRLVAIPE-PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG+ +LEC+ V++P+ + W E+I PD+ + ++ L I
Sbjct: 2410 VIEGTKAVLECK-VSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQR----LVINRTHAS 2464
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
EG Y ++ E +L + KIK +I L+ + + ++V+ ++ +
Sbjct: 2465 DEGPYKLIVGRVETNCNLSVE-KIK--------IIRGLRDLTCTETQNVVFEVEL-SHSG 2514
Query: 764 PTITWC---KNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+ W K KP ++ G + +T+L K DEG YT A G TS +
Sbjct: 2515 IDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMK-DDEGKYTFYA----GENMTSGKL 2569
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV PL + TV E V NP W R+ + + + I
Sbjct: 2570 TVAGGA---ISKPL-----TDQTVAESQEAVFECEVA-NPDSKGEWLRDGKHLPLTNNIR 2620
Query: 881 QNFDGENIELVI--TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
DG L+I T +D +I YK S ++ K + VE V K L+
Sbjct: 2621 SESDGHKRRLIIAATKLD-DIGEYTYKVATSKTSAK--------LKVEAVKIKKTLKNLT 2671
Query: 939 ETEEGKTVI-LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
TE V +E + +W N + + I +G D V
Sbjct: 2672 VTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVY 2731
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
+ S L V ET+ + I+K +D E EV ++ +T V W IK
Sbjct: 2732 GFRLGRLGASARLHV-ETV-KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIK 2789
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
P +K+ + KL ++N S D GEY+ ++ C A++ V L I ++N +
Sbjct: 2790 PS-DKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL--HITKTMKNIE 2846
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + A+FE E++ + W K+G EI+ S ++ + GK +L I + +D+ EY+
Sbjct: 2847 VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT 2906
Query: 1178 CEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE 1237
GN + +A LTV I T L + +T + V + E + W K I+
Sbjct: 2907 FVCGNDQVSATLTVTP--IMITSMLKDINAEEKDTITF-EVTVNYEGISYKWLKNGVEIK 2963
Query: 1238 DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV--VEFPPKIVDYER 1295
T+K + + +L IR D +YT V A ST L VE +EF I D +
Sbjct: 2964 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDI-K 3022
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDA 1355
KR + + P +W+ + + ++ K + L I +DA
Sbjct: 3023 VLEKKRAMFECEVSE----PDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 3078
Query: 1356 GIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
G Y + N A + + + S + ++E + + +E + +
Sbjct: 3079 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 3138
Query: 1416 VVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+ +Q + +++ + I + S Y F A + S T Y
Sbjct: 3139 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGR-------NRSSVTLYVNAP- 3190
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENR 1532
+ P V + L+ +T + + + G PQPK++WY++ + L T K ++ +
Sbjct: 3191 ----EPPQVLQELQPVTVQSGKPARFCAMISGRPQPKISWYKEEQLLSTGFKCKFLHDGQ 3246
Query: 1533 XXXXXXXXXX-XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A ND+G TS + ++ V++ E +
Sbjct: 3247 EYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQ 3306
Query: 1592 VTAVIEGIPPP----------EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
T EG P +V WY K++ + + +T E T + I E
Sbjct: 3307 DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 3366
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRE 1681
YT A+N G S L + + P I +EI E
Sbjct: 3367 TYTFVANNAVGQVSSTANLSL-EAPESILHERIEQEIEME 3405
Score = 171 bits (415), Expect = 3e-41
Identities = 164/708 (23%), Positives = 296/708 (41%), Gaps = 36/708 (5%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKT 1436
+D P PPGKP + ++ +S+ + W +PE+ G + I YV+E + T EW+ V + + T
Sbjct: 7484 IDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVPTT 7543
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNIT-TEP 1495
Q + L Y FR AVN+ S+ SE ++ V+ K+ P+ + L+ I T+
Sbjct: 7544 QHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSD--PVLCREKLYPPSPPRWLEVINITKN 7601
Query: 1496 NEDIELTCIF--GGVPQPK-VTWYRDGKKL------KTAKATYENRXXXXXXXXXXXXXX 1546
D++ T GG P + RD ++ T K T
Sbjct: 7602 TADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVA 7661
Query: 1547 XYKCIAFNDHGEVETSCVVG---IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE 1603
I +D+ E+E S + P ++ D+ ++H V +W G P
Sbjct: 7662 AENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRH-VDLKWEPPKNDGGRPIQR 7720
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT---SSVEVTL 1660
+ K +L T R+ ++ ++ + A N AG S L
Sbjct: 7721 YVIEKK-ERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEIL 7779
Query: 1661 KVYDKPSKPEGPVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
+ D S P P+ + + R+ + I WKPP +GG + Y +E +W++V
Sbjct: 7780 SIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNS 7839
Query: 1719 VD-RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXX 1776
+D++ + + + EY+ RV A N +G SE E SE +V K P+
Sbjct: 7840 RPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDI 7899
Query: 1777 XXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQ-KLSINTTY 1835
I+ E + I P + P + + + K+ + A ++ S+
Sbjct: 7900 IVIEGEKLSIP-VPF-RAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADA 7957
Query: 1836 Q-FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
+ I N++G++ T+ + K + P ++ S+ T S L W PE +GG
Sbjct: 7958 GIYTITLENKLGSA---TASINV---KVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGG 8011
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
+PI +Y++E + +++ +++ G + ++++ E FR+ A N VG E
Sbjct: 8012 TPILHYVLERREAGRRTYIPVMS-GENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIEL 8070
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
++ + + P P +E+ + + +W P +DGG+ ++GY I + W
Sbjct: 8071 KNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWK 8130
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVI 2062
+ V L + + L E Y R+ A N G+SEP + P K +
Sbjct: 8131 RCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAV 8178
Score = 167 bits (407), Expect = 3e-40
Identities = 246/1096 (22%), Positives = 440/1096 (40%), Gaps = 86/1096 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P ++ ++Q V +GSD R+V P+P+ W G +I + I D C
Sbjct: 2032 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPED--NVCE 2089
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
L I +V + V A+N GE S L ++ K+ + L+ ++ ++ +++
Sbjct: 2090 -LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA--KQLITFTQELQDVVAKEKDTMA 2146
Query: 754 LSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
P + W K+ V SD H ++IL D Y+
Sbjct: 2147 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSIL-TIDTSDAEDYSCVLVED 2205
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
E + +T+A + VE E F+ Q+I V E + +L V+ + WY N+
Sbjct: 2206 ENV-KTTAKLIVEGAVVE------FVKELQDIEVPESYSGELECIVSPENIEG-KWYHND 2257
Query: 871 -EIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
E+ S + TIT +N L + +V E D G+Y V GK + ++ + +
Sbjct: 2258 VELKSNGKYTITSRRGRQN--LTVKDVTKE-DQGEYSFVID---GKKT-TCKLKMKPRPI 2310
Query: 929 TFVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
++ L + EG V LE + S +V W + +E+ D I+ + +
Sbjct: 2311 AILQGL-SDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIE 2369
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
D G + ST V + I L+D V E A+LE +++ +
Sbjct: 2370 DMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTS 2429
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELP 1106
V W + E IKP ++ +G ++L I T DEG Y I+ ++V ++
Sbjct: 2430 VKWYLNDEQIKP-DDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI- 2487
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVRW-FKDGSEIQFSNHIQLTIDGKKQKLKI 1165
+II L++ + FE+EL+ V W FKD EI+ S+ ++ GK KL +
Sbjct: 2488 -KIIRGLRDLTCTETQNVVFEVELSHSGIDVLWNFKD-KEIKPSSKYKIEAHGKIYKLTV 2545
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
+ DD G+Y+ G + + LTV +I+ L V + +A E+ +
Sbjct: 2546 LNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQ---TVAESQEAVFECEVANPDS 2602
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
W + + T SD KR LII DD EYT + +K++ KLKVE V
Sbjct: 2603 KGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAV- 2661
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
KI + + D V+ +WI N +++ + S+ SL
Sbjct: 2662 ---KIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSL 2718
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEM-NVTILDKPSPPGKPNILEIDSSSINICWDEP 1404
IK D +Y RL A + + V I+ KP ++ ++++++
Sbjct: 2719 RIKNCAIVDESVYGFRLGRLGASARLHVETVKIIKKPK-----DVTALENATVAFEVSVS 2773
Query: 1405 ENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDA 1464
+T + VE + D +S + + K +QN+ + + + A V +++
Sbjct: 2774 HDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLM--LQNISPSDAGEYTA-VVGQLECK-- 2828
Query: 1465 SETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
K+ ET + K +KNI + C P + W ++G +++
Sbjct: 2829 ------AKLFVETL----HITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEM 2877
Query: 1525 A---KATYENR-XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDI 1580
+ K + + Y + ND +V + V +IT +DI
Sbjct: 2878 SEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGND--QVSATLTV---TPIMITSMLKDI 2932
Query: 1581 KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHS 1640
+ K + VT EGI W KNG ++++ + + TK+ T + I+ + +
Sbjct: 2933 NAEEKDTITFEVTVNYEGI---SYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDA 2989
Query: 1641 SKYTIEASNTAGTSSVEVTLKVYD--------KPSKPEGPVIMREISRESVTIEWKPPLD 1692
+ YT A T+++ V + + K + + + E+S +T++W D
Sbjct: 2990 ADYTFVAGKATSTATLYVEARHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMK--D 3047
Query: 1693 DGGLELT-KYAIEKHE 1707
D L++T + I+K +
Sbjct: 3048 DQELQITDRIKIQKEK 3063
Score = 167 bits (406), Expect = 4e-40
Identities = 189/777 (24%), Positives = 330/777 (42%), Gaps = 67/777 (8%)
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
+P+ EWIV + ++ CK+ S+T K +E + ++++R EN G ++
Sbjct: 8348 KPDSEWIVVTSTLRHCKY----------SVT-KLIEGKEY-LFRVRAENRFGPGPPCVSK 8395
Query: 1376 TILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV 1430
++ K P P KP + ++ S+S+ + W+EP++ G S I+ Y +E +E+++T W V
Sbjct: 8396 PLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNG-SPILGYWLEKREVNSTHWSRV 8454
Query: 1431 KN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL 1488
+ + ++ L +Y FR A N S ++ P + +
Sbjct: 8455 NKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVT 8514
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXX 1544
+T + E GG ++ Y K+L K ++ T +
Sbjct: 8515 DTSSTTIELEWEPPAFNGG---GEIVGYFVDKQLVGTNKWSRCTEKMIKVRQYTVKEIRE 8571
Query: 1545 XXXYKC--IAFNDHGEV---ETSCV-VGIQQKPVITISNEDIKQKHKV--GDEWLVTAVI 1596
YK A N GE ET V V Q+P + +K ++ G + AV+
Sbjct: 8572 GADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVV 8631
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
G P P +W K +L+ D+ K+ +I IK+ R +Y I A+N+ G+
Sbjct: 8632 TGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELI-IKDALRKDHGRYVITATNSCGSKFA 8690
Query: 1657 EVTLKVYDKPSKPEGPVI-MREI--SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW 1713
++V+D P GPV+ ++ + +R+ + W P DDGG E+T + IE+ + + W
Sbjct: 8691 AARVEVFDVP----GPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTW 8746
Query: 1714 IKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
+ + +R + C I L E EY FRVIA+N G +E PI+ L P+
Sbjct: 8747 RQPIETER---SKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPER 8803
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK---KWKXXXXXXXXXARIQKL 1829
++ + W NGGSPI Y +E ++ K + ++ L
Sbjct: 8804 LTYTER-QRSTITLDWKEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENL 8862
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP 1889
+ Y+FR+ A NEIG S P + + + P + R V ++ P
Sbjct: 8863 DEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIP 8922
Query: 1890 ESNGGSPI-------TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
G P+ +IE T + + V+ + E I +D+ + ++A
Sbjct: 8923 ADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTA 8982
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
N +G + ++V +E + PSPP L + + + +W P +GG+ + Y
Sbjct: 8983 SNRLG----SVFRNVHVEVYDR-PSPP-RNLAVTDIKAESCYLTWDAPLDNGGSEITHYV 9036
Query: 2003 IAIRDVT--KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
I RD + K W EV V ++ I L N Y R+ A N+ G+S+ +SD+
Sbjct: 9037 IDKRDASRKKAEWEEVTNTAVEK-RYGIWKLIPNGQYEFRVRAVNKYGISDECKSDK 9092
Score = 164 bits (399), Expect = 3e-39
Identities = 239/1087 (21%), Positives = 452/1087 (41%), Gaps = 84/1087 (7%)
Query: 629 LEGIPPTFSKKPKAQYVDE----GSDILLECRLVAIPEPDIAWLFKGEEIVPD-ENISVA 683
L+ +P F K+ K + E GS + EC LV+ W+ G I ++ +A
Sbjct: 4613 LKAVPLKFVKEIKDIILTESEFVGSSAIFEC-LVSPSTAITTWMKDGSNIRESPKHRFIA 4671
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAV--NREGEASLPIVLKIKTGEKEPPQVIEPL 741
D ++ I +V+ G YT V N+E ++ +V+ E+ P + ++ L
Sbjct: 4672 DGKDRKLH-----IIDVQLSDAGEYTCVLRLGNKEKTSTAKLVV-----EELPVRFVKTL 4721
Query: 742 KSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD----GDTHSITILKPKK 796
+ + V +G+ + LS ++ N + W K+ K V P + G ++TI
Sbjct: 4722 EEEVTVVKGQPLYLSCEL--NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADD 4779
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D G YT+ EN+ + +S V VE + +P ++ VK KGT +
Sbjct: 4780 T-DAGTYTVTVENANNLECSSCVKVVEVIRDWLVKP------IRDQHVKPKGTAIFACDI 4832
Query: 857 TRNPVPSITWYRNNEII--SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
++ P+I W++ + I P++ DG ++ L I N E D +Y A GK
Sbjct: 4833 AKD-TPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPE-DIAEY---AVEIEGK 4887
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHR 973
+ A++T+ +V +K ++ E ++ + + S + +W + +
Sbjct: 4888 R-YPAKLTLGEREVELLKPIE-DVTIYEKESASFDAEISEADIPGQWKLKGELLRPSPTC 4945
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDV 1033
EI EG G + + T+ +L VKE +F L+D V E+
Sbjct: 4946 EIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQ 5005
Query: 1034 AILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
A E + E A+V+W + +IIK +K+D G L I ++ DEG Y+ +
Sbjct: 5006 ARFECVLTRE-ANVIWSKGPDIIK-SSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEG 5063
Query: 1094 ESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
+ +A + V + + ++ L++Q V +G ATF EL+ V WFK+ +++ S +
Sbjct: 5064 KKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVL 5123
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTD 1213
++ +GK KL++ + LDD + +V TA L V E FT++L + V + +
Sbjct: 5124 ISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKD-E 5182
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
L E+ + + V W+K I + K+++ +D +R L I+K D+ EY C
Sbjct: 5183 ITLKCEV-SKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTD 5241
Query: 1274 KSTTKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLLVDYQ-AFPQPNDEWIVNSKIIKKC 1331
K+ + VE ++++ E+ Y ++ T + + + P + +W + + +
Sbjct: 5242 KTKANVTVEA-----RLIEVEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTAS 5296
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
+ D K L + + G + N A++++ L +P + E
Sbjct: 5297 PDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVFE 5356
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS-VKNITKTQTSIQN--LKTNSS 1448
D + E E + ++ QEI + +K+ TK I++ + +
Sbjct: 5357 KDEAKF-----ECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAK 5411
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGV 1508
Y F A + T +I+ +++ T PLK++T + E T
Sbjct: 5412 YMFEA----------EDKHTSGKLIIEGIRLKFLT---PLKDVTAKEKESAVFTVELSH- 5457
Query: 1509 PQPKVTWYRDGKKLKTAKA-TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
+V W+++ ++L T ++ + ++ I G + + +
Sbjct: 5458 DNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVL 5517
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+ P T +D K DE ++ I P V W+K+G +++ K I T K
Sbjct: 5518 EGDPYFTGKLQDYTGVEK--DEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKTDGKK 5574
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI-SRESVTIE 1686
++ +K+ +S +YT + GT L + D+ K P+ E+ E+ E
Sbjct: 5575 RMLILKKALKSDIGQYTCD----CGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFE 5630
Query: 1687 WKPPLDD 1693
+ DD
Sbjct: 5631 TEISEDD 5637
Score = 164 bits (399), Expect = 3e-39
Identities = 221/972 (22%), Positives = 399/972 (41%), Gaps = 75/972 (7%)
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY-SCEV-GNSKC 1185
IE+ K D L W K +E +T ++ K ++ AG+ SCEV G K
Sbjct: 21793 IEMCKTD-LGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKA 21851
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLI 1245
LT E I+ + + A+ ++ + T W K S + + + +
Sbjct: 21852 VDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQ-GRPTPTAVWSKPDSNL--SLRADIH 21908
Query: 1246 SDVKKRTLIIRKCTEDDQCEYTCVLLD---AKSTT-KLKVEVVEFPPKIVDYEREYRIKR 1301
+ TL + C +D +YT + + +KS T +KV PP + ++ + R
Sbjct: 21909 TTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKD---VTR 21965
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS--IDSKSASLTIKKVENTDAGI-- 1357
GS TL+ D P + ++ +++K + ++ S + S+ + I KV + G+
Sbjct: 21966 GS-ATLMWDA---PLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPY 22021
Query: 1358 -YKLRLENNCGHAD-VEMNVTIL--DKPSPPGKPNILEIDSSSINICWDEPENTGNSTII 1413
+++ N G + EM I+ ++P+PP + ++++ SS + W +P++ G S I
Sbjct: 22022 YFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRIT 22081
Query: 1414 YYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
Y++E ++ + W+ + + +++ L + Y FR A N+ S+ E +
Sbjct: 22082 GYLLEMRQKGSDLWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSV-I 22140
Query: 1474 IKETKIQSPTVEKPLKN--ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK----TAKA 1527
IKE +I+ + N IT + + G P PKVTW + +LK +
Sbjct: 22141 IKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSIT 22200
Query: 1528 TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVG 1587
T ++R Y N G S V + +P ++ V
Sbjct: 22201 TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVS---SVS 22257
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKY--- 1643
E + V+ P + + N + +E T + S ++ ++K +H +KY
Sbjct: 22258 AE---SCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEY 22314
Query: 1644 --TIEASNTAGTSSVEVTLKV-----YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGL 1696
+ + N G S + + + PS P P + +S +++I W+ P DGG
Sbjct: 22315 SFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVY-HVSANAMSIRWEEPYHDGGS 22373
Query: 1697 ELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-S 1755
++ Y +EK E + W+K V Y + L E EY FR A N G S+A E S
Sbjct: 22374 KIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEAS 22433
Query: 1756 EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK---- 1811
PI+ + +D P + +V + W +GGS ++ Y +E K +
Sbjct: 22434 RPIMAQNPVDAPG----RPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDG 22489
Query: 1812 KWK--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGT-SLPYTSDDKITIGKTLTPPSQ 1868
+W + LS TY+FR+ A+N G S S +T PP
Sbjct: 22490 RWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 22549
Query: 1869 PRNF-VVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV--GGSVHEH 1925
+ + + + + GG P II K K + V++ G
Sbjct: 22550 ELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK-IIWTKGDKELDLCEKVSLQYTGKRATA 22608
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP-PTAPLEIRMVGSNIVM 1984
I+ D + ++ +N G T++ SV ++ + SP P L + V
Sbjct: 22609 VIKFCDRSDSGKYTLTVKNASG----TKAVSVMVK---VLDSPGPCGKLTVSRVTQEKCT 22661
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
+W P+ DGGA + Y + R+ ++ W+ V + + TL + + L +N+ Y+ R+ A
Sbjct: 22662 LAWSLPQEDGGAEITHYIVERRETSRLNWVIV-EGECPTLSYVVTRLIKNNEYIFRVRAV 22720
Query: 2045 NEIGLSEPLESD 2056
N+ G P+ES+
Sbjct: 22721 NKYGPGVPVESE 22732
Score = 164 bits (398), Expect = 4e-39
Identities = 180/733 (24%), Positives = 292/733 (39%), Gaps = 51/733 (6%)
Query: 1358 YKLRLENNCGHADVEMN---VTILDKPSPPGKP-NILEIDSS--SINICWDEPENTGNST 1411
++++ EN G + + V D PPG P N +D++ SI + W +P G +
Sbjct: 11971 FRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAP 12030
Query: 1412 IIYYVVEYQE--IDTTE---W---ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISD 1463
II YVVE + D + W + + + + ++ +L N Y FR A N+V I
Sbjct: 12031 IIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGR 12090
Query: 1464 ASETTEYYKVIKETKIQSPTVE---KPLKNITTEPNEDIELTCIFGGVPQPKVTWYR--- 1517
+E E K KE ++ P ++ K + I L I G P PKVTW +
Sbjct: 12091 PAELKEAIKP-KEI-LEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGI 12148
Query: 1518 DGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK--PVITI 1575
D K + Y N GE V + PV +
Sbjct: 12149 DNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL 12208
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKE 1634
D+ K W A E +V Y + + K ++ T E K + +
Sbjct: 12209 KVSDV-TKTSCHVSW---APPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTN 12264
Query: 1635 LKRSHSSKYTIEASNTAG---TSSVEVTLKVYDKPSKPEGP--VIMREISRESVTIEWKP 1689
L + + + A N G + V + D S+P+ P + E+++ S T+ W P
Sbjct: 12265 LVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEATEMTKNSATLAWLP 12324
Query: 1690 PLDDGGLELTKYAIEKHEPDN--NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PL DGG ++ Y I E + +RW + + V +D+ + + L E +Y FRV A+N V
Sbjct: 12325 PLRDGGAKIDGYIISYREEEQPADRWTEYS-VVKDL-SLVVTGLKEGKKYKFRVAARNAV 12382
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S E+E + +P + + I K P +K
Sbjct: 12383 GVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGK--PHPTCKWKKGED 12440
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ I+ ++ + + + A N GT T K+ + P
Sbjct: 12441 EVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTD---TQKIKVVVMDAPGP 12497
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P F +S+ + + +L W P +GGS ITNYI+E V W + +
Sbjct: 12498 PQPP--FDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDW--VTALASVTKTS 12553
Query: 1926 C-IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVM 1984
C + + E IFR+ AEN G+S P S + + VPS P + V + +
Sbjct: 12554 CRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEP-KNARVTKVNKDCIF 12612
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
+W P+ DGG+P++GY I ++ +W++ V + ++ L E Y RIYA
Sbjct: 12613 VAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYAL 12672
Query: 2045 NEIGLSEPLESDE 2057
N+ G S P + E
Sbjct: 12673 NKAGSSPPSKPTE 12685
Score = 161 bits (391), Expect = 2e-38
Identities = 169/711 (23%), Positives = 283/711 (39%), Gaps = 48/711 (6%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK--NITK 1435
LD PPGKP L I ++ + W +PE TG I Y+VE +++ W+ NI +
Sbjct: 14857 LDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILE 14916
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVD-ISDASETTEYYKVIKETKIQSPTVEKPLK---NI 1491
+ ++ L +++Y FR A N IS SE ++ + +++P ++ +K +
Sbjct: 14917 NEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSD--AITCRDDVEAPKIKVDVKFKDTV 14974
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXX---XXX 1547
+ E L G P P + W +DGK+L+ TAK +
Sbjct: 14975 ILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGA 15034
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWY 1607
Y A N G + V + +P E +V E V+ PP +
Sbjct: 15035 YTLTATNPGGFAKHIFNVKVLDRPG---PPEGPLAVTEVTSE---KCVLSWFPPLDDGGA 15088
Query: 1608 KNGNKLENDKEY------NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-----SSV 1656
K + + +E N+ ++ + + +++ +L + + + + A N G S
Sbjct: 15089 KIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEP 15148
Query: 1657 EVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV 1716
+ + Y P P+ P + I+++S+ + W P DGG E+ Y +E+ + RWIK
Sbjct: 15149 VLAVNPYGPPDPPKNPEVTT-ITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKC 15207
Query: 1717 ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXX 1776
Y + L E EY FR++A+N G S + P
Sbjct: 15208 NKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRV 15267
Query: 1777 XXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXAR---IQKLSIN 1832
S+ I W +GGS I Y VEI E +W+ A I L+ N
Sbjct: 15268 LDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTEN 15327
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES-TSRSV-TLKWTEPE 1890
Y+ RIYA N G P + PP + + + T R+ TL+ P
Sbjct: 15328 QEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPI 15387
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE-NIKEKDEIIFRISAENTVGVS 1949
P + + G+S K S + I N+ D + ++ EN+ G
Sbjct: 15388 KGRPDPEVKWARDH----GESLDKASIESASSYTLLIVGNVNRFDSGKYILTVENSSG-- 15441
Query: 1950 LPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVT 2009
++S V + T P PP L+++ V V +W P DGG+ + Y + R+ T
Sbjct: 15442 --SKSAFVNVRVLDT-PGPPQ-DLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKREST 15497
Query: 2010 KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
+ + V + + + + L E +Y R+ A NE G+ P E+ E K
Sbjct: 15498 RKAYSTVA-TNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVK 15547
Score = 160 bits (389), Expect = 4e-38
Identities = 192/881 (21%), Positives = 342/881 (38%), Gaps = 84/881 (9%)
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPK 1289
K V + E L + +II +C +Y+ + + T +V+V++ P
Sbjct: 9358 KDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGP 9417
Query: 1290 IVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-------WIVNSKIIKKCKHTKPSIDSKS 1342
D + SD+T ++ P+D+ +++ + I TK + D S
Sbjct: 9418 PKDL-------KVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGS 9470
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCG---HADVEMNVTILDK---PSPPGKPNILEIDSSS 1396
+ + + + +++R EN G + T D P PP K I I ++
Sbjct: 9471 TTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNT 9530
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTT-----EW--ISVKNITKTQTSIQNLKTNSSY 1449
+++ W P+N G S + +Y+VE D T W + +++ + Q ++++L Y
Sbjct: 9531 VHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEY 9590
Query: 1450 RFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNEDIELTCIFGGV 1508
FR AVN +S S T + P+++ LK + E ++ + GV
Sbjct: 9591 EFRVKAVNAAGVSKPSATVGPCDC--QRPDMPPSID--LKEFMEVEEGTNVNIVAKIKGV 9646
Query: 1509 PQPKVTWYR------DGKK-----LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG 1557
P P +TW++ D K+ K ++ Y A N+ G
Sbjct: 9647 PFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLG 9706
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK 1617
+ + +P + IK + D+ + PP + K N + +
Sbjct: 9707 TASKEMRLNVLGRPGPPVG--PIKFESVSADQ----MTLSWFPPKDDGGSKITNYVIEKR 9760
Query: 1618 EYN------ITTKEKTSVIRIKELKRSHSSKYTIEASNTAG-----TSSVEVTLKVYDKP 1666
E N ++++ K I +L H + I A N G S E ++ P
Sbjct: 9761 EANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVP 9820
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVE- 1724
P+ P + ++R S+T+ W+ P DGG +T Y +E + + RW +V D + +
Sbjct: 9821 GAPDKPTV-SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTL 9879
Query: 1725 --TYCIQKLNENCEYMFRVIAQNPVGFSEA-LESEPIVIKTALDVPSXXXXXXXXXXIDN 1781
+Y + L E +Y FRV A N G A L S+P + + P
Sbjct: 9880 GVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWT--K 9937
Query: 1782 ESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXAR--IQKLSINTTYQFR 1838
S + W P K+GGS + Y VE K+EGK +W+ + + L Y+FR
Sbjct: 9938 SSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFYKFR 9997
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESNGGSP 1896
+ A N G P D I + L P + V + ++ S P
Sbjct: 9998 VSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPP 10057
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQS 1956
+ + +T+ ++ + + S+ I+N + + ++ + A+N G E +
Sbjct: 10058 TVTWNMNERTLPQEATIETTAISSSM---VIKNCQRSHQGVYSLLAKNEAG-----ERKK 10109
Query: 1957 VRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV 2016
+ VP P P + + +W +PE DGG+P+ Y I R+ + W V
Sbjct: 10110 TIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPV 10169
Query: 2017 GKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
V ++ L + Y RI A N IG+ +E+ E
Sbjct: 10170 -TYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSE 10209
Score = 159 bits (387), Expect = 8e-38
Identities = 115/396 (29%), Positives = 184/396 (46%), Gaps = 15/396 (3%)
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
D P +PE VI +R +VT++WK P DGG ++T Y +EK + + RW+K + +
Sbjct: 18107 DPPGRPEAIVI----TRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLE 18162
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVG-FSEALESE-PIVIKTALDVPSXXXXXXXXXXIDN 1781
+ + L E+ Y FRVIA+N G FSE +S I + +D P+ I
Sbjct: 18163 TEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVV 18222
Query: 1782 ESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ T+ G PI D V ++GK+ + + IQK ++ R
Sbjct: 18223 HAGE-TFVLEADIRGKPIPD--VVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 18279
Query: 1842 RNEIG--TSLPYTSDDKITIGKTLTPPSQPRN-FVVSESTSRSVTLKWTEPESNGGSPIT 1898
I +++ T IT+ K L P P V+ T+ L W P +GG+ I+
Sbjct: 18280 GQYILKLSNVGGTKSIPITV-KVLDRPGSPEGPLKVTGVTAEKCYLAWNPPLQDGGANIS 18338
Query: 1899 NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
+YIIE + SWT++ T +++ + + + +E IFR+ A N G+ P ES V
Sbjct: 18339 HYIIEKRETSRLSWTQVSTEVQALN-YKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVT 18397
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
P PP+ P E+ + + ++ +W P DGG + GY + RD W + K
Sbjct: 18398 ACNPYKPPGPPSTP-EVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNK 18456
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
+ L+ + L+E H+Y R+ A N G+ EP E
Sbjct: 18457 KTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSE 18492
Score = 159 bits (385), Expect = 1e-37
Identities = 157/704 (22%), Positives = 281/704 (39%), Gaps = 35/704 (4%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITK 1435
+++PSPP + SS+ + W+ P G S I+ Y++E E WI ++K + +
Sbjct: 6792 IERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPE 6851
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTE- 1494
+ L+ + Y +R A N+ +SD SE + + PT++ E
Sbjct: 6852 LTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILG--PLTADDAFVEPTMDLSAFKDGLEV 6909
Query: 1495 --PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIA 1552
PN I + G P+P TW K L+T K I
Sbjct: 6910 IVPNP-ITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGI- 6967
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE-----VIWY 1607
+ E + G + V I+ ++ K GD + + PP + + Y
Sbjct: 6968 YTLKLENRVKTISG--EIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGY 7025
Query: 1608 KNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTSS---VEVTLKVY 1663
+ + K + T + + +L + + + A N G V+ + +
Sbjct: 7026 VVEKREVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMS 7085
Query: 1664 DKPSKPEGP--VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
+ P+ P V R+ + S+ + W PP +DGG + Y +E+ +++W+ +
Sbjct: 7086 TPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVA 7145
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXID 1780
+ + + L E Y +RV N G S+ + +E I + P +
Sbjct: 7146 ETKME-VTGLEEGKWYAYRVKTLNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLT 7204
Query: 1781 NESVYITWFPSEKNGG-SPIIDY-KVE-IKQEGKKWKXXXXXXXXXARIQKLSINTTYQF 1837
++ P+ G P I + K + I ++ K+ I + T +
Sbjct: 7205 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 7264
Query: 1838 RIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPI 1897
I A N G + T+ ++ + L P P F +++ T+ S L W P +GGS I
Sbjct: 7265 IIEAVNVCGRA---TAVVEVNV---LDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKI 7318
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
TNY++E + + W K+ + + + I K E IFR++AEN G P ++ +
Sbjct: 7319 TNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNK-EYIFRVAAENMYGAGEPVQASPI 7377
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
+ P PPT LE + + V +W P+ DGG+P+ GY + D W+
Sbjct: 7378 TAKYQFDPPGPPTR-LEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWVRCN 7436
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
K+ V + ++ L+ Y R+ A N G +P +S EP +
Sbjct: 7437 KMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILI 7480
Score = 158 bits (384), Expect = 2e-37
Identities = 122/395 (30%), Positives = 175/395 (44%), Gaps = 18/395 (4%)
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
D P +PE ++ +R SVT++WK P DGG ++T Y +EK E RW+K A +
Sbjct: 15943 DPPGRPEAIIV----TRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRWMK-ASFTNII 15997
Query: 1724 ETYC-IQKLNENCEYMFRVIAQNPVG-FSEALESE-PIVIKTALDVPSXXXXXXXXXXID 1780
+T+ + L E+ Y FRVIA+N G FSE ES I + +D P I
Sbjct: 15998 DTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIV 16057
Query: 1781 NESVYITWFPSEKNGGS-PIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRI 1839
+ ++ G P I + IK + + LS+ R+
Sbjct: 16058 VHAGESFKVDADIYGKPIPTIQW---IKGDQELSNTARLEIKSTDFATSLSVKDAV--RV 16112
Query: 1840 YARNEIGTSLPYTSDDKITIG-KTLTPPSQPRN-FVVSESTSRSVTLKWTEPESNGGSPI 1897
+ N I + + +T+ K L P P V+S T+ TL W P +GGS I
Sbjct: 16113 DSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDI 16172
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
NYI+E + WT +V + + E +E FRI A N GV P ES+ V
Sbjct: 16173 INYIVERRETSRLVWT-VVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPV 16231
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
+ VP P AP E+ V + ++ W P DGG+ +LGY + RD W
Sbjct: 16232 VAKNPFVVPDAPKAP-EVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCH 16290
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
K + L+ + L ENH Y R+ A N GLSEP
Sbjct: 16291 KRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEP 16325
Score = 156 bits (378), Expect = 9e-37
Identities = 106/368 (28%), Positives = 166/368 (45%), Gaps = 15/368 (4%)
Query: 1623 TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRES 1682
+K+ S +R+++ R Y I+ N G + T+ V D P P + +I + S
Sbjct: 8262 SKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN-FVFEDIRKTS 8320
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHE---PDNNRWIKVADVDRDVETYCIQKLNENCEYMF 1739
V +W+PPLDDGG E+ Y +EK + PD+ WI V R + Y + KL E EY+F
Sbjct: 8321 VLCKWEPPLDDGGSEIINYTLEKKDKTKPDSE-WIVVTSTLRHCK-YSVTKLIEGKEYLF 8378
Query: 1740 RVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
RV A+N G S+P+V K P N S+ + W K+ GSPI
Sbjct: 8379 RVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN-SMLVKW-NEPKDNGSPI 8436
Query: 1800 IDYKVEIKQ-EGKKWKXXXXXXXXX--ARIQKLSINTTYQFRIYARNEIGTSLPYTSDDK 1856
+ Y +E ++ W A + L TY FR+ A N G D
Sbjct: 8437 LGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDP 8496
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
T ++PP P V ++++S ++ L+W P NGG I Y ++ + V W++
Sbjct: 8497 KTAHDPISPPGPPIPRV-TDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNKWSRCT 8555
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIR 1976
V ++ ++ I+E + R+SA N G P E+Q V + A PP L++
Sbjct: 8556 EKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTV---AEPQEPPAVELDVS 8612
Query: 1977 MVGSNIVM 1984
+ G +M
Sbjct: 8613 VKGGIQIM 8620
Score = 155 bits (376), Expect = 2e-36
Identities = 180/814 (22%), Positives = 322/814 (39%), Gaps = 64/814 (7%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
K +D+ V + P +IV + +++ K T+ + +++
Sbjct: 7600 KNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFR 7659
Query: 1360 LRLENNCGHAD-VEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTII 1413
+ EN G +D E+ ++L K P PP ++++ +++ W+ P+N G I
Sbjct: 7660 VAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQ 7719
Query: 1414 YYVVEYQEIDTTEWISVKNITKTQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
YV+E +E T W+ + + ++ + +F+ A NE + SE TE
Sbjct: 7720 RYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGHPSEPTEIL 7779
Query: 1472 KVIKETKIQSPTVEKPLKN-------ITTEPNEDIELTCIFGG----VPQPKVTWYR-DG 1519
+ T SP ++ + + I +P E + I G P W R +
Sbjct: 7780 SIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNS 7839
Query: 1520 KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ-KPVITISNE 1578
+ +K K E I ++ E+ + V KP I +
Sbjct: 7840 RPIKDLKFKVEE--GVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETH 7897
Query: 1579 DIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
DI G++ + +P P V W+K+G +++ + ++ + + + R+
Sbjct: 7898 DIIVIE--GEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRA 7955
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLEL 1698
+ YTI N G+++ + +KV P P + +I++ S + W+PP DGG +
Sbjct: 7956 DAGIYTITLENKLGSATASINVKVIGLPG-PCKDIKASDITKSSCKLTWEPPEFDGGTPI 8014
Query: 1699 TKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
Y +E+ E +I V + + ++ ++ L N EY FRV A N VG E +E +
Sbjct: 8015 LHYVLERREAGRRTYIPVMSGENKL-SWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNP 8073
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWK--X 1815
VI P E++ ITW P +GGS I+ Y +E I + ++WK
Sbjct: 8074 VIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCN 8133
Query: 1816 XXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-V 1874
+ L YQFR+ A N G S P + K + P P+ +
Sbjct: 8134 EHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPT---KAVDPIDAPKVILRT 8190
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYI-----IEFKTVKGKSWTKIVTVGGSVHEH---- 1925
S R + S P +I I + +K ++ + G V E
Sbjct: 8191 SLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFV 8250
Query: 1926 -------CIENIKE-KDEIIFRISAENTVGV-SLPTESQSVRLEKHATVPSPPTAPLEIR 1976
I+N K+ + ++ R S G+ + E+ + TV T I
Sbjct: 8251 LPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPIN 8310
Query: 1977 MVGSNI----VMTSWGTPEWDGGAPLLGYNIAIRDVTK--TMWMEVGKVDVNTLKFNIRD 2030
V +I V+ W P DGG+ ++ Y + +D TK + W+ V + K+++
Sbjct: 8311 FVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTST-LRHCKYSVTK 8369
Query: 2031 LSENHTYMIRIYARNEIG-----LSEPLESDEPF 2059
L E Y+ R+ A N G +S+PL + +PF
Sbjct: 8370 LIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPF 8403
Score = 153 bits (371), Expect = 7e-36
Identities = 122/482 (25%), Positives = 207/482 (42%), Gaps = 33/482 (6%)
Query: 1594 AVIEGIPPPEVIWYKNGNKLEND-KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
A++ G P P+V W K G ++N ++ + + + + I R S KY++ N AG
Sbjct: 12131 AIVRGRPAPKVTWRKVG--IDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAG 12188
Query: 1653 TSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR 1712
+V V ++V D P P + + ++++ S + W PP +DGG ++T Y +EK E D
Sbjct: 12189 EKAVFVNVRVLDTPG-PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKT 12247
Query: 1713 WIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXX 1771
W V + ++ + L EY FRV A N G + +P++ L P
Sbjct: 12248 WSTVTPEVKKT-SFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPR 12306
Query: 1772 XXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQE---GKKWKXXXXXXXXXARIQK 1828
N S + W P ++GG+ I Y + ++E +W +
Sbjct: 12307 KLEATEMTKN-SATLAWLPPLRDGGAKIDGYIISYREEEQPADRWTEYSVVKDLSLVVTG 12365
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
L Y+FR+ ARN +G SLP ++ + L PP ++ E + K
Sbjct: 12366 LKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPP----KILMPEQITIKAGKKLRI 12421
Query: 1889 PESNGGSPITNYIIEFKTVKGKSWTKIVTVGG-SVHEH------CIENIKEKDEIIFRIS 1941
G P K KG+ ++VT +VH+ I+++ KD + ++
Sbjct: 12422 EAHVYGKPHPT----CKWKKGED--EVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLT 12475
Query: 1942 AENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGY 2001
AEN+ G T++Q +++ P PP P +I + ++ SW P DGG+ + Y
Sbjct: 12476 AENSSG----TDTQKIKVVV-MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNY 12530
Query: 2002 NIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
+ DV++ W+ V + L Y+ R+ A N G+SEPL S +
Sbjct: 12531 IVEKCDVSRGDWV-TALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQ 12589
Query: 2062 IP 2063
P
Sbjct: 12590 FP 12591
Score = 153 bits (370), Expect = 9e-36
Identities = 116/432 (26%), Positives = 195/432 (45%), Gaps = 20/432 (4%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY--DKPSKPEGPVIMREISRESVTIEWK 1688
+ + L+ ++ + A N G + Y P P G + R +T++W
Sbjct: 16986 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWT 17045
Query: 1689 PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET-YCIQKLNENCEYMFRVIAQNPV 1747
P+ DGG +T Y +EK + + RW+K A +ET + + L E+ Y FRVIA+N
Sbjct: 17046 KPVYDGGSMITGYIVEKRDLPDGRWMK-ASFTNVIETQFTVSGLTEDQRYEFRVIAKNAA 17104
Query: 1748 G-FSEALESE-PIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGS-PIIDYKV 1804
G S+ +S PI K +++P I + ++ +G P I++
Sbjct: 17105 GAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLR 17164
Query: 1805 EIKQEGKKWKXXXXXXXXXAR-IQKLSINTTY-QFRIYARNEIGT-SLPYTSDDKITIGK 1861
K+ + + A I K +I Q+ + A N G+ S P K
Sbjct: 17165 GDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNV-------K 17217
Query: 1862 TLTPPSQPRNFV-VSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG 1920
L P P V V+ TS +L W+ P +GGS I++Y++E + +WT +V
Sbjct: 17218 VLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLAWT-VVASEV 17276
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGS 1980
+ + + E +E +FRI A N GV P ES V ++ +P PP + LE+ +
Sbjct: 17277 VTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKS-LEVTNIAK 17335
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+ + W P+ DGG+ ++GY + RD + W++ K + L+ + L+E+H Y R
Sbjct: 17336 DSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFR 17395
Query: 2041 IYARNEIGLSEP 2052
+ A N G+ EP
Sbjct: 17396 VSAENAAGVGEP 17407
Score = 153 bits (370), Expect = 9e-36
Identities = 112/414 (27%), Positives = 181/414 (43%), Gaps = 14/414 (3%)
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P KP+ P + + +R SV++ W P D+GG ++T Y IE + D + W K +
Sbjct: 23536 PGKPQNPRVT-DTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIRE 23594
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV-IKTALDVPSXXXXXXXXXXID-NES 1783
Y + L + EY FRV+A N G E E V + L+ P I +
Sbjct: 23595 YTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQG 23654
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
I K PI + E + K+ I++ + + + N
Sbjct: 23655 GVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLEN 23714
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
+ G Y K+ + + P P + + RSV + W P +GG+ I YI+E
Sbjct: 23715 KCGKKAVYI---KVRVIGSPNSPEGPLEY--DDIQVRSVRVSWRPPADDGGADILGYILE 23769
Query: 1904 FKTVKGKSWTKIVT-VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQS-VRLEK 1961
+ V +W I + V G+ ++ +KE E FR+SAEN G+S P +S+ V +
Sbjct: 23770 RREVPKAAWYTIDSRVRGT--SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKT 23827
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
P PP+ P E+ V + V SW P+ DGG+ + GY I ++ + + K +
Sbjct: 23828 PLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKVVRHNKTQI 23887
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
T + + L + Y RI A+N++GLSE + EP V+ + +PGE
Sbjct: 23888 TTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEP--VVCKDPFDKPSQPGE 23939
Score = 151 bits (365), Expect = 4e-35
Identities = 177/746 (23%), Positives = 297/746 (39%), Gaps = 54/746 (7%)
Query: 1349 KVENTDAGI-YKLRL--ENNCGHADVEMN---VTILDKPSPPGKPNILEIDSSSINICWD 1402
K +N + GI Y+ R+ EN G N D PPG P + + + I + W
Sbjct: 16986 KAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWT 17045
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
+P G S I Y+VE +++ W+ S N+ +TQ ++ L + Y FR A N
Sbjct: 17046 KPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG 17105
Query: 1461 -ISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
IS S++T E ++ +++ ++ I E L G P P + W R
Sbjct: 17106 AISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRG 17165
Query: 1519 GKKLK-TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT 1574
K+++ +A+ +N + Y A N G V + +P
Sbjct: 17166 DKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPP 17225
Query: 1575 ISNEDIK--QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIR 1631
+ K W G ++ Y + + + + E T+ ++
Sbjct: 17226 EGPVQVTGVTSEKCSLTWSPPLQDGG---SDISHYVVEKRETSRLAWTVVASEVVTNSLK 17282
Query: 1632 IKELKRSHSSKYTIEASNTAGTSS-VEVTLKVYDKPSKPEGP---VIMREISRESVTIEW 1687
+ +L + + I A N G +E + P GP + + I+++S+T+ W
Sbjct: 17283 VTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCW 17342
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P DGG E+ Y +EK + RWIK + L E+ EY FRV A+N
Sbjct: 17343 NRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAA 17402
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDN--ESVYITWFPSEKNGGSPIIDYKVE 1805
G E S V A D +D S+ + W +GGS I+ Y VE
Sbjct: 17403 GVGEP--SPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVE 17460
Query: 1806 I-KQEGKKWKXXXXXXXXXA---RIQKLSINTTYQFRIYARNEIG----TSLPYT--SDD 1855
I K + ++W+ I KL+ + Y+ R+ A N++G TS+P T +D
Sbjct: 17461 ICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPED 17520
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
K+ + + VV S + + + G P+ I + +G+ K+
Sbjct: 17521 KLEAPELDLDSELRKGIVVRAGGSARIHIPFK------GRPMPE--ITWSREEGEFTDKV 17572
Query: 1916 -VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLE 1974
+ G + + I+N D + + EN+ G ++S V + K P PP L
Sbjct: 17573 QIEKGVNYTQLSIDNCDRNDAGKYILKLENSSG----SKSAFVTV-KVLDTPGPPQN-LA 17626
Query: 1975 IRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSEN 2034
++ V + W P DGGA + Y I R+ T+ + V T F + +L+E
Sbjct: 17627 VKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKT-SFKVENLTEG 17685
Query: 2035 HTYMIRIYARNEIGLSEPLESDEPFK 2060
Y R+ A NE G+ P+E+ + K
Sbjct: 17686 AIYYFRVMAENEFGVGVPVETVDAVK 17711
Score = 149 bits (362), Expect = 8e-35
Identities = 198/893 (22%), Positives = 344/893 (38%), Gaps = 49/893 (5%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVK 1249
+E P I+ + + ++V A L + VTW +K I++ + + V
Sbjct: 12104 LEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTW--RKVGIDNVVRKGQVDLVD 12161
Query: 1250 KRT-LIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
L+I T DD +Y+ L++ + + V V++ P + D + K V+
Sbjct: 12162 TMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVS 12221
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
+IV + + + + + K S + + + +++ N
Sbjct: 12222 WAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEY 12281
Query: 1367 GHA---DVEMNVTILD---KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
G DV V D +P PP K E+ +S + W P G + I Y++ Y+
Sbjct: 12282 GPGVPTDVPKPVLASDPLSEPDPPRKLEATEMTKNSATLAWLPPLRDGGAKIDGYIISYR 12341
Query: 1421 EID--TTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK 1478
E + W + + LK Y+FR A N V +S E Y+ KE +
Sbjct: 12342 EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA-KE-Q 12399
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATY--ENRXX 1534
+ P + P + IT + + + + G P P W + ++ T+ A + ++
Sbjct: 12400 LLPPKILMP-EQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI 12458
Query: 1535 XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK--QKHKVGDEWLV 1592
Y A N G V + P DI W +
Sbjct: 12459 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHI 12518
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
G I + + D + + KTS R+ +L + + A N G
Sbjct: 12519 PLEDGGSNITNYI-VEKCDVSRGDWVTALASVTKTS-CRVGKLIPGQEYIFRVRAENRFG 12576
Query: 1653 TSSVEVTLKV-----YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
S + K+ + PS+P+ + + ++++ + + W P DGG + Y IE+ E
Sbjct: 12577 ISEPLTSPKMVAQFPFGVPSEPKNARVTK-VNKDCIFVAWDRPDSDGGSPIIGYLIERKE 12635
Query: 1708 PDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP 1767
++ W+K D Y L E EY FR+ A N G S S+P TA +P
Sbjct: 12636 RNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSP--PSKPTEYVTA-RMP 12692
Query: 1768 SXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWKXXXXXXXXXARI 1826
+ +V + W + +GGS II Y VE K G KW +
Sbjct: 12693 VDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQE 12752
Query: 1827 Q----KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVV-SESTSRS 1881
+ L YQFR AR + S P D +TI PP + + S T ++
Sbjct: 12753 EYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKA 12812
Query: 1882 VTLKWTEPESNG-GSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
T + G P ++ + +K K + + ++ + ++ KD + I
Sbjct: 12813 GTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIK-MAMQRNLCTLELFSVNRKDSGDYTI 12871
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
+AEN+ G ++S +++L K P PP A ++I + S+ M SW P DGG+ +
Sbjct: 12872 TAENSSG----SKSATIKL-KVLDKPGPP-ASVKINKMYSDRAMLSWEPPLEDGGSEITN 12925
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
Y + R+ ++ W +V V ++ L E H Y RI A N+ G+ +P+
Sbjct: 12926 YIVDKRETSRPNWAQV-SATVPITSCSVEKLIEGHEYQFRICAENKYGVGDPV 12977
Score = 149 bits (361), Expect = 1e-34
Identities = 101/331 (30%), Positives = 156/331 (47%), Gaps = 12/331 (3%)
Query: 1733 ENCEYMFRVIAQNPVGFSEALESEPIVIK-TALDVPSXXXXXXXXXXIDNESVYITWFPS 1791
+NC + R + + S A S+ + + T LDVP + E + I+W P
Sbjct: 11074 KNC--LRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPP 11131
Query: 1792 EKNGGSPIIDYKVEIKQEGKK--WKXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTS 1848
+ +GGSP+I+Y VE KQ+ +K W +I L Y FR+ A N+IG
Sbjct: 11132 KDDGGSPVINYIVE-KQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVG 11190
Query: 1849 LPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVK 1908
P S + K +PPS P VV++ T + T+ WT P+S+GGSPIT Y +E + V
Sbjct: 11191 PPLDSTPTVAKHK-FSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVT 11249
Query: 1909 GKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQS-VRLEKHATVPS 1967
GK W ++ + + + + E + FR+ AEN G+S P+ S ++ + P
Sbjct: 11250 GK-WVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPG 11308
Query: 1968 PPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD-VNTLKF 2026
PP P +++ W P DGG+P+LGY + + W + K + + F
Sbjct: 11309 PPINP-KLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAF 11367
Query: 2027 NIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
+ L E + Y RI A N +G EP E E
Sbjct: 11368 RVPGLIEGNEYRFRIKAANIVGEGEPRELAE 11398
Score = 149 bits (360), Expect = 1e-34
Identities = 174/780 (22%), Positives = 293/780 (37%), Gaps = 59/780 (7%)
Query: 1358 YKLRLENNCGHADVE--MNVTILDKP-SPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
+++ EN+ G + T+ P PPG P+ +++ +I + W+ P G S I+
Sbjct: 21332 FRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVG 21391
Query: 1415 YVVEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD-ISDASETTEYY 1471
Y +E ++ W+ + ++++ Q ++ L Y FR A N V IS S+++
Sbjct: 21392 YSIEKRQ-GNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGI- 21449
Query: 1472 KVIKETKIQSPTVE---KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG----KKLKT 1524
++ + P VE + + + E + + + G P P+VTW++DG K++
Sbjct: 21450 -IMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNM 21508
Query: 1525 AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH 1584
Y A N G + V +Q P + I+ +
Sbjct: 21509 EITNVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVG--PIRFTN 21566
Query: 1585 KVGDE---WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
G++ W + +G P I + K E + ++K +K + +
Sbjct: 21567 ITGEKMTLWWDAPLNDGCAP---ITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGN 21623
Query: 1642 KY--TIEASNTAGT----SSVEVTLKV-YDKPSKPEGPVIMREISRESVTIEWKPPLDDG 1694
+Y + A N G S V ++ Y P P P I+ S+T+ W P DG
Sbjct: 21624 EYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPE-PSNITGNSITLTWARPESDG 21682
Query: 1695 GLELTKYAIEKHEPDNNRWIKVADVDRDVET-YCIQKLNENCEYMFRVIAQNPVGFSEAL 1753
G E+ +Y +E+ E + RW+KV ET + + L E EY F V+A+N G A
Sbjct: 21683 GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPAS 21742
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI-KQEGKK 1812
++ P +V + W +GG II Y +E+ K +
Sbjct: 21743 GISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKTDLGD 21802
Query: 1813 WKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQ-- 1868
W R + L Y+FR+ A N G I LT P
Sbjct: 21803 WHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDI 21862
Query: 1869 PRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE 1928
NF + +++ + G P T + K S + S +E
Sbjct: 21863 DANFKQTHVVRAGASIRLF--IAYQGRP-TPTAVWSKPDSNLSLRADIHTTDSFSTLTVE 21919
Query: 1929 NIKEKDEIIFRISAENTVGVSLPTESQSVRLE-KHATVPSPPTAPLEIRMVGSNIVMTSW 1987
N D + ++ EN G S+S+ K P PP P+ + V W
Sbjct: 21920 NCNRNDAGKYTLTVENNSG------SKSITFTVKVLDTPGPP-GPITFKDVTRGSATLMW 21972
Query: 1988 GTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P DGGA + Y + R+ ++ W + + + F + DL+E Y R+ A NE
Sbjct: 21973 DAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQI-FKVNDLAEGVPYYFRVSAVNEY 22031
Query: 2048 GLSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLR-EHNMDADIRSY 2106
G+ EP E EP A E+P + WL+ +H+ + I Y
Sbjct: 22032 GVGEPYEMPEPIV--------ATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGY 22083
Score = 146 bits (354), Expect = 8e-34
Identities = 117/440 (26%), Positives = 188/440 (42%), Gaps = 28/440 (6%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD------KPSKPEGPVIMREISRESVT 1684
++ L H ++ I A N AG S+ T Y KP P P ++ + SR S++
Sbjct: 15218 KVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVL-DTSRSSIS 15276
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
I W P+ DGG E+T Y +E P+ + W I +Y I L EN EY R+ A
Sbjct: 15277 IAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 15336
Query: 1744 QNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVY-ITWFPSEKNGGSPIID 1801
N G E AL + + P + + + F K P +
Sbjct: 15337 MNSEGLGEPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPDPEVK 15396
Query: 1802 YKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK 1861
+ + + K + ++ + ++ + N G+ + + +
Sbjct: 15397 WARDHGESLDKASIESASSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNV------R 15450
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
L P P++ V E T SVTL W P +GGS I NYI+E + K+++ TV +
Sbjct: 15451 VLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKRESTRKAYS---TVATN 15507
Query: 1922 VHEHC--IENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMV 1978
H+ ++ ++E FR+ AEN G+ LP E ++SV+ + P PP + + V
Sbjct: 15508 CHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASER---PLPP-GKITLMDV 15563
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
N V SW PE DGG+ +LGY + ++ W V V + I L + Y
Sbjct: 15564 TRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVT--EATITGLIQGEEYS 15621
Query: 2039 IRIYARNEIGLSEPLESDEP 2058
R+ A+NE G+S+P + P
Sbjct: 15622 FRVSAQNEKGISDPRQLSVP 15641
Score = 142 bits (344), Expect = 1e-32
Identities = 203/913 (22%), Positives = 365/913 (39%), Gaps = 83/913 (9%)
Query: 793 KPKKVKDEGVYTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINR-FQEITVKEKGT 849
K + V + V+ L +N E +AV+ E + L I + + I V E T
Sbjct: 2793 KHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKT 2852
Query: 850 IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS 909
V+ VPS+ W +N I SE G+ +L+I N +E DS +Y V
Sbjct: 2853 ASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE-DSAEYTFVCG 2910
Query: 910 NSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEIS 968
N T+ V + L K EE T+ E ++ +S KW N EI
Sbjct: 2911 NDQ------VSATLTVTPIMITSML-KDINAEEKDTITFEVTVNYEGISYKWLKNGVEIK 2963
Query: 969 GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEV 1028
D ++ + D + ++ L V+ EF + ++D +V
Sbjct: 2964 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDIKV 3023
Query: 1029 KEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
EK A+ E E++ V W +D + ++ ++ +K ++ +L I +T + D G+Y+
Sbjct: 3024 LEKKRAMFECEVSEPDITVQWMKDDQELQIT-DRIKIQKEKYVHRLLIPSTRMSDAGKYT 3082
Query: 1089 CILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQF 1148
+ TA++ V I + + +V + +A E E+ + D W+KDG EI F
Sbjct: 3083 VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINF 3142
Query: 1149 S--NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFI 1206
+ ++ + ++ I + DAGEY+ G ++ + L V P L+ + +
Sbjct: 3143 QVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPV 3202
Query: 1207 LVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V + A I ++WYK++ ++ K + D ++ TL++ + +D
Sbjct: 3203 TVQSGKPARFCAMISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAV 3262
Query: 1266 YTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD-YQAFPQP-ND 1319
YTC + A ++ L VEV P++V ++E + + +T L D + QP
Sbjct: 3263 YTCEAKNDYGVATTSASLSVEV----PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 3318
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
+ V+ +K ++K S + + E+T Y+L + + + E T +
Sbjct: 3319 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT----YQLEIAE--AYPEDEGTYTFVA 3372
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
N + SS+ N+ + PE+ I++ +E QEI+ + +K + + S
Sbjct: 3373 N-------NAVGQVSSTANLSLEAPES-----ILHERIE-QEIE----MEMKEFSSSFLS 3415
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQSPTVEKPLKNITTEPNED 1498
+ +S+ + +NE + SE+ Y K E + P K + N +
Sbjct: 3416 AEEEGLHSA-ELQLSKINET-LELLSESPVYPTKFDSEKEGTGPIFIKEVSNADISMGDV 3473
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-----NRXXXXXXXXXXXXXXXYKCIAF 1553
L+ G+P+PK+ W+ +G L T A Y+ + Y C+A
Sbjct: 3474 ATLSVTVIGIPKPKIQWFFNG-VLLTPSADYKFVFDGDDHSLIILFTKLEDEGEYTCMAS 3532
Query: 1554 NDHGEVETSCVVGIQQK----------PVITISNED---------IKQKHKVGDEWLVTA 1594
ND+G+ S + I K + S E +K+ + + A
Sbjct: 3533 NDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPA 3592
Query: 1595 VIE----GIPPPEVIWYKNGNKLENDKEYNITTKEKTS-VIRIKELKRSHSSKYTIEASN 1649
+ E G P P V W+K +L Y I S + + +R S Y +A N
Sbjct: 3593 IFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAEN 3652
Query: 1650 TAGTSSVEVTLKV 1662
G S+ L V
Sbjct: 3653 MLGESTCAAELLV 3665
Score = 141 bits (341), Expect = 3e-32
Identities = 102/345 (29%), Positives = 149/345 (43%), Gaps = 14/345 (4%)
Query: 1739 FRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSP 1798
+ + A N G ++A + IV+ LD P I ESV + W P + +GGS
Sbjct: 20050 YEITAANSSGTTKAFIN--IVV---LDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQ 20104
Query: 1799 IIDYKVEIKQEGKK--W-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDD 1855
+ +Y + +K+E W + ++ KL+ YQFRI A N G S +
Sbjct: 20105 VTNY-ILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGIS-DHIDSA 20162
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+T+ T P P V+ T S+T+ W EP SNGGS + Y +E K W K
Sbjct: 20163 CVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQKA 20222
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ + I FR+ AEN GV P+ L A P + I
Sbjct: 20223 NKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVLAIDAC---EPPRNVRI 20279
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENH 2035
+ N V SW P +DGG+ + GY + RD+ W + +V +F I L++N
Sbjct: 20280 TDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFTISGLTQNS 20339
Query: 2036 TYMIRIYARNEIG-LSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
Y R++ARN +G +S P E P I G + P E TEV
Sbjct: 20340 QYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEV 20384
Score = 136 bits (328), Expect = 1e-30
Identities = 196/790 (24%), Positives = 318/790 (40%), Gaps = 70/790 (8%)
Query: 1214 AYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL- 1271
A L+ +I L D+ WY+ + + K+ + SD + TL + ++D+ YTC+
Sbjct: 24053 AQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATN 24112
Query: 1272 ---DAKSTTKLKVEVV-EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
+ ++++KL ++ +F P E+ Y GS + L V Y P P W K+
Sbjct: 24113 EVGEVETSSKLLLQATPQFHPGYPLKEKYYGAV-GSTLRLHVMYIGRPVPAMTWFHGQKL 24171
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVE-NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
++ ++ L +K V+ T AG YK++L N G D ++V I DKP P
Sbjct: 24172 LQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTG 24231
Query: 1387 PNILE-IDSSSINICWDEPENTGNSTIIYYVVEYQEI-DTTEWISVKN-ITKTQTSIQNL 1443
P ++E + +S I W P + G S I YVVE E + EW V + I+ T I NL
Sbjct: 24232 PIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNL 24291
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTC 1503
N+ Y FR A N ISD E + VI ++ + P P K T +D +C
Sbjct: 24292 TENAGYYFRVSAQNTFGISDPLEVSSV--VIIKSPFEKPGA--PGKPTITAVTKD---SC 24344
Query: 1504 IFGGVPQ-----PKVTWY----RDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIA 1552
+ P K+ Y R+ K+ K T E Y +
Sbjct: 24345 VVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKC 24404
Query: 1553 FNDHGEVETSCV-VGIQQKPVITISNEDIKQKHK---VGDEWLVTAV--IEGIPPPEVIW 1606
N GE E S + I K + I K++ + V + T V + G P P V W
Sbjct: 24405 ENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKW 24464
Query: 1607 YKNGNKLEND-KEYNITT-KEKTSVIRIKELKRSHSSKYTIEASNTAGTSS------VEV 1658
Y+ G ++ D +Y I K + I + ++ Y + A+N G+ S VEV
Sbjct: 24465 YRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEV 24524
Query: 1659 TLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
K++ P EG + + E V+I K P + + + DNN +V
Sbjct: 24525 PAKIH-LPKTLEGMGAVHALRGEVVSI--KIPFSGKPDPVITWQKGQDLIDNNGHYQVI- 24580
Query: 1719 VDRDVETYCIQKLNENCEYMFRVI-AQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXX 1777
V R + E + F V+ A+N G ++ + + + A DVP
Sbjct: 24581 VTRSFTSLVFPNGVERKDAGFYVVCAKNRFG----IDQKTVELDVA-DVPDPPRGVKVSD 24635
Query: 1778 XIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWKXXXXXXXXXARIQKLSINTTYQ 1836
+SV +TW +GGS I +Y VE ++W + L T+YQ
Sbjct: 24636 A-SRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQ 24694
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
FR+ A N+ G S P + T+T + R E + + T+ +
Sbjct: 24695 FRVIAENKFGLSKPSEPSE-----PTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKE 24749
Query: 1897 I-TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQ 1955
+ Y+I +G+ G VH C+E +K + + + T V + E
Sbjct: 24750 LYEKYMIAEDLGRGEF--------GIVH-RCVETSSKKTYMAKFVKVKGTDQVLVKKEIS 24800
Query: 1956 SVRLEKHATV 1965
+ + +H +
Sbjct: 24801 ILNIARHRNI 24810
Score = 133 bits (321), Expect = 8e-30
Identities = 159/677 (23%), Positives = 272/677 (40%), Gaps = 67/677 (9%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
KKPK E + + E + P + W K EI P + + E +H L +
Sbjct: 2753 KKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHRLVSERKVHK----LML 2807
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
N+ G YT V E +A L + E + + +K++ V + ++ +
Sbjct: 2808 QNISPSDAGEYTAVVGQLECKAKLFV---------ETLHITKTMKNIEVPETKTASFECE 2858
Query: 758 VVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V P++ W KN ++ G H + I+ +D YT N +
Sbjct: 2859 VSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTS-TEDSAEYTFVCGNDQ--- 2913
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
SA +TV P + + ++I +EK TI V + S W +N I
Sbjct: 2914 -VSATLTVT--------PIMITSMLKDINAEEKDTITFEVTVNYEGI-SYKWLKNGVEIK 2963
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL 934
++ L I NV D+ DY VA GK++ A + ++ + F KH+
Sbjct: 2964 STDKCQMRTKKLTHSLNIRNVHFG-DAADYTFVA----GKATSTATLYVEARHIEFRKHI 3018
Query: 935 QKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD 993
K + E K + EC+ S ++ +W + +E+ D +I +E D
Sbjct: 3019 -KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3077
Query: 994 VGVIKCIVKDQETSTMLVVKETIPEFIRKLQ-DFEVKEKDVAILEVEINSETADVVWERD 1052
G +V ST + E IR ++ + +V EK A++E E+N + D W +D
Sbjct: 3078 AGKYT-VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3136
Query: 1053 GEIIK---PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL-RDESCTAEVTVVELPPE 1108
G I +++KY E+R H +++I T D GEY+ + R+ S PP+
Sbjct: 3137 GIEINFQVQERHKYVVERRIH--RMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQ 3194
Query: 1109 IITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
++ LQ V G A F ++ + + W+K+ + + DG++ L + +
Sbjct: 3195 VLQELQPVTVQSGKPARFCAMISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIE 3254
Query: 1168 CDLDDAGEYSCEVGN----SKCTAILTVEEPSI-NFTLRLPEF---ILVPANTD------ 1213
+DA Y+CE N + +A L+VE P + + +P + I+ P
Sbjct: 3255 AFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQ 3314
Query: 1214 -AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
A + L V+WY K I+ + F + L I + +D+ YT V +
Sbjct: 3315 PARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVANN 3374
Query: 1273 A----KSTTKLKVEVVE 1285
A ST L +E E
Sbjct: 3375 AVGQVSSTANLSLEAPE 3391
Score = 133 bits (321), Expect = 8e-30
Identities = 118/411 (28%), Positives = 171/411 (41%), Gaps = 31/411 (7%)
Query: 1666 PSKPEGPVIMREIS---RESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
P KP GP E+S ++S+ + W P+DDGG E+ Y +EK + + RW K
Sbjct: 18401 PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLT 18460
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV--PSXXXXXXXXXXID 1780
+ L E Y FRV A+N G E SEP V A D P
Sbjct: 18461 DLRLRVTGLTEGHSYEFRVAAENAAGVGEP--SEPSVFYRACDALYPPGPPSNPKVTDTS 18518
Query: 1781 NESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXAR---IQKLSINTTYQ 1836
SV + W +GG+P+ Y VE+K+ +W + + KL NT Y
Sbjct: 18519 RSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYN 18578
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPP-----SQPRNFVVSESTSRSVTLKWTEPES 1891
FRI A N G P T + + + PP + R VV + S TL+
Sbjct: 18579 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA---SATLRLFVTIK 18635
Query: 1892 NGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
P ++++ +G + + V S I+N+ D + ++ EN G
Sbjct: 18636 GRPEP----EVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSK- 18690
Query: 1951 PTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTK 2010
T +VR+ PS P L IR V + V SW P DGGA + Y + R+ T+
Sbjct: 18691 -TAFVNVRV---LDSPSAP-VNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTR 18745
Query: 2011 TMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
+ + T F I +L E +Y R+ A NE G+ P E+ EP KV
Sbjct: 18746 KAYATITNNCTKT-TFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKV 18795
Score = 126 bits (305), Expect = 7e-28
Identities = 84/279 (30%), Positives = 124/279 (44%), Gaps = 7/279 (2%)
Query: 1782 ESVYITWFPSEKNGGSPIIDYKVEIKQE-GKKWKXXXXXXXXXA-RIQKLSINTTYQFRI 1839
E++ + W P + +GGS I +Y +E + KW R+ +L Y FR+
Sbjct: 13594 EAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRV 13653
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N+ G S+ + P + P +V + SV+L WT+P+ GGSPIT
Sbjct: 13654 SAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIV-DVRHDSVSLTWTDPKKTGGSPITG 13712
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
Y +EFK W + + + + + E E FR+ A N GV P+ +
Sbjct: 13713 YHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVV 13772
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
A P P E+ + N V W P++DGG L GY + RD+ WM+ V
Sbjct: 13773 ---ALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHV 13829
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIG-LSEPLESDE 2057
+V F + DL E Y RI A+N G +S P ES E
Sbjct: 13830 NVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTE 13868
Score = 126 bits (304), Expect = 9e-28
Identities = 86/303 (28%), Positives = 131/303 (43%), Gaps = 7/303 (2%)
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-K 1812
+S PI +K LD P + E Y+ W P ++GG+ I Y +E ++ +
Sbjct: 18293 KSIPITVKV-LDRPGSPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLS 18351
Query: 1813 W-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
W + ++ KL Y FR+ A N+ G P S +T PP P
Sbjct: 18352 WTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGP-VTACNPYKPPGPPST 18410
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIK 1931
VS T S+ + W P +GG+ I YI+E + +G WTK + + +
Sbjct: 18411 PEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLT 18470
Query: 1932 EKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP 1990
E FR++AEN GV P+E S R P PP+ P ++ + V +W P
Sbjct: 18471 EGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNP-KVTDTSRSSVSLAWSKP 18529
Query: 1991 EWDGGAPLLGYNIAIRDVTKTMWME-VGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGL 2049
+DGGAP+ GY + +++ W + +F + L EN Y RI A N G+
Sbjct: 18530 IYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGV 18589
Query: 2050 SEP 2052
EP
Sbjct: 18590 GEP 18592
Score = 124 bits (300), Expect = 3e-27
Identities = 90/303 (29%), Positives = 135/303 (44%), Gaps = 11/303 (3%)
Query: 1757 PIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKX 1815
PI + T L PS I +SV ++W E NGG I Y +E ++ + WK
Sbjct: 21151 PITVIT-LGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKM 21209
Query: 1816 XXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK-TLTPPSQPRNFV 1873
++ L + YQFR+ A N G S P S I + K P P V
Sbjct: 21210 VCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSS--IIVAKHQFRIPGPPGKPV 21267
Query: 1874 VSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEK 1933
+ TS ++L W P +GGS +T + +E K W K+ T S E+ + E
Sbjct: 21268 IYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEG 21327
Query: 1934 DEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+ FR+ AEN+ G+S P++ L + PP P I + I + W P D
Sbjct: 21328 LDYQFRVYAENSAGLSSPSDPSKFTLA--VSPVDPPGTPDYIDVTRETITL-KWNPPLRD 21384
Query: 1994 GGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG-LSEP 2052
GG+ ++GY+I R + W+ DV+ ++ + LS Y RI ARN +G +S P
Sbjct: 21385 GGSKIVGYSIEKRQGNER-WVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPP 21443
Query: 2053 LES 2055
+S
Sbjct: 21444 SQS 21446
Score = 124 bits (298), Expect = 5e-27
Identities = 123/454 (27%), Positives = 188/454 (41%), Gaps = 34/454 (7%)
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
T+ ++ L ++ ++A N G S + L V + + P I +S TI+
Sbjct: 8854 TTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVP-PTIKLRLSVRGDTIK 8912
Query: 1687 WKP------PLDDGGLELTKYAIEKHE-----PDNNRWIKVADVDR-DVET-YCIQKLNE 1733
K P D GL + K K+E P + I +V R + +T I K
Sbjct: 8913 VKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVR 8972
Query: 1734 NCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEK 1793
+ + V A N +G + + + D PS I ES Y+TW
Sbjct: 8973 EDKGTYTVTASNRLG--SVFRNVHVEV---YDRPSPPRNLAVTD-IKAESCYLTWDAPLD 9026
Query: 1794 NGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXAR-IQKLSINTTYQFRIYARNEIGTSL 1849
NGGS I Y ++ + +K W+ I KL N Y+FR+ A N+ G S
Sbjct: 9027 NGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISD 9086
Query: 1850 PYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKG 1909
SD K+ I P P V T S+ + WT P NGGSPIT Y +E +
Sbjct: 9087 ECKSD-KVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPITGYWLEKREEGS 9145
Query: 1910 KSWTK-----IVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHAT 1964
W++ I VG E + + E + FR A N G+ P+E +
Sbjct: 9146 PYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPI 9205
Query: 1965 VP-SPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD--V 2021
P PP+ P E++ + + W P DGG+P+ GY + +++ T W V + D +
Sbjct: 9206 FPPGPPSCP-EVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLI 9264
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
T + + +L E Y R+ A NE G SEP ++
Sbjct: 9265 TTCECVVPNLKELRKYRFRVKAVNEAGESEPSDT 9298
Score = 123 bits (297), Expect = 6e-27
Identities = 83/293 (28%), Positives = 131/293 (44%), Gaps = 15/293 (5%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK--WKXXXXXXXX-XARIQKLSINTTY 1835
+ ++ + W P E +GG I +Y +E K E K+ W + +L Y
Sbjct: 11811 VSSDRCTVCWDPPEDDGGCEIQNYILE-KCETKRMVWSTYSATVLTPGTTVTRLIEGNEY 11869
Query: 1836 QFRIYARNEIGTSLPYTSDDKITIGKT-LTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
FR+ A N+IGT P ++ K I KT P +P V++ + +T+ W PE +GG
Sbjct: 11870 IFRVRAENKIGTGPP--TESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGG 11927
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT-E 1953
IT Y +E K W + ++N+ E FR+ AEN +G+ P+
Sbjct: 11928 KSITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLP 11987
Query: 1954 SQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMW 2013
S+ V + P PPT + +I + WG P +DGGAP++GY + +R
Sbjct: 11988 SRPVVAKDPIEPPGPPTNFRVVDTTKHSITL-GWGKPVYDGGAPIIGYVVEMRPKIADAS 12046
Query: 2014 MEVGKVDVNTL------KFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
+ G N +F + L EN Y R+ A+N++G+ P E E K
Sbjct: 12047 PDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIK 12099
Score = 121 bits (292), Expect = 2e-26
Identities = 144/607 (23%), Positives = 240/607 (39%), Gaps = 44/607 (7%)
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAK-ATYENRXXXXXXXXXX----XXXXXYKCIAF 1553
+ L ++ G P P +TW+ K L+ ++ T EN YK
Sbjct: 24149 LRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLS 24208
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV--IWYKNG- 1610
N G V+ V IQ KP I+ K +AVI PP + W N
Sbjct: 24209 NVFGTVDAILDVEIQDKPDKPTGPIVIEALLKN------SAVISWKPPADDGGSWITNYV 24262
Query: 1611 -NKLENDK--EYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAG------TSSVEVTL 1660
K E + E+ + + + RI L + + + A NT G SSV +
Sbjct: 24263 VEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIK 24322
Query: 1661 KVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVD 1720
++KP P P I ++++S + WKPP DGG ++ Y +EK E N+WI V +
Sbjct: 24323 SPFEKPGAPGKPTITA-VTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEE 24381
Query: 1721 RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXI 1779
+ ++ L E EY FRV +N G SE E SEPI K+ + + +
Sbjct: 24382 IRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLN 24441
Query: 1780 DNESVYITWFPSEKNGGSPIIDYK---VEIKQEGKKWKXXXXXXXXXARI-QKLSINTTY 1835
T PI+ + EI +G K++ I ++ +
Sbjct: 24442 VRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDAT 24501
Query: 1836 QFRIYARNEIGTSLPYTSDDKITI-GKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
+++ A N+ G S+ T+ ++ + K P + V V++K P S
Sbjct: 24502 VYQVRATNQ-GGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI--PFSGKP 24558
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
P+ + + +++ ++ KD + + A+N G+ +
Sbjct: 24559 DPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI----DQ 24614
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
++V L+ A VP PP +++ + V +W P DGG+ + Y + T W+
Sbjct: 24615 KTVELDV-ADVPDPPRG-VKVSDASRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWL 24672
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP--FKVIPGEGSHADEE 2072
VG+ ++ + +L +Y R+ A N+ GLS+P E EP K + DEE
Sbjct: 24673 RVGQA--RETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITKEDKTRAMNYDEE 24730
Query: 2073 PGEQTEV 2079
E EV
Sbjct: 24731 VDETREV 24737
Score = 119 bits (287), Expect = 1e-25
Identities = 88/313 (28%), Positives = 138/313 (44%), Gaps = 10/313 (3%)
Query: 1764 LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXX 1822
LD P + E + W P ++GGS II+Y VE ++ + W
Sbjct: 16137 LDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQT 16196
Query: 1823 XA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS 1881
+ ++ KL Y FRI A N+ G P S+ + + P + P+ V+ T S
Sbjct: 16197 LSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDA-PKAPEVTTVTKDS 16255
Query: 1882 VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRI 1940
+ + W P S+GGS I Y++E + +G WT+ + G + + + E + FR+
Sbjct: 16256 MIVVWERPASDGGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLR-VTGLIENHDYEFRV 16314
Query: 1941 SAENTVGVSLPTESQSVRLEKHATV-PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLL 1999
SAEN G+S P+ + + P PP P I + S++ + SW P +DGG +
Sbjct: 16315 SAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFL-SWSKPIYDGGCEIQ 16373
Query: 2000 GYNIAIRDVTKTMW-MEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
GY + DV W M +N + L E H Y RI A N+ G+ E +D P
Sbjct: 16374 GYIVEKCDVNVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGE--HADVP 16431
Query: 2059 FKVIPGEGSHADE 2071
+I E A +
Sbjct: 16432 GPIIVEEKLEAPD 16444
Score = 115 bits (276), Expect = 2e-24
Identities = 109/456 (23%), Positives = 179/456 (39%), Gaps = 28/456 (6%)
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
EY++ V +KE K+ K+ + A N G S VY+ + P I+
Sbjct: 12352 EYSVVKDLSLVVTGLKEGKKY---KFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMP 12408
Query: 1678 ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEY 1737
E +TI+ L + + K P +W K D + K + +
Sbjct: 12409 ---EQITIKAGKKL-----RIEAHVYGKPHP-TCKWKKGEDEVVTSSHLAVHKADSSSIL 12459
Query: 1738 MFRVIAQNPVGF-------SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
+ + + + G+ S +++ I + +D P ID ++ ++W
Sbjct: 12460 IIKDVTRKDSGYYSLTAENSSGTDTQKIKV-VVMDAPGPPQPPFDISDIDADACSLSWHI 12518
Query: 1791 SEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTS 1848
++GGS I +Y VE + W + R+ KL Y FR+ A N G S
Sbjct: 12519 PLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGIS 12578
Query: 1849 LPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVK 1908
P TS K+ PS+P+N V++ + + W P+S+GGSPI Y+IE K
Sbjct: 12579 EPLTSP-KMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN 12637
Query: 1909 GKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
W K E+ + E E FRI A N G S P++ A +P
Sbjct: 12638 SLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVT---ARMPVD 12694
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV--DVNTLKF 2026
P E+ V + V W P+ DGG+ ++GY + + W+ + ++
Sbjct: 12695 PPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEY 12754
Query: 2027 NIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVI 2062
L E Y R AR + +S P E +P ++
Sbjct: 12755 TATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 12790
Score = 108 bits (260), Expect = 2e-22
Identities = 117/515 (22%), Positives = 208/515 (40%), Gaps = 31/515 (6%)
Query: 1554 NDHGEVETSCVVGIQQK--PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWY--KN 1609
NDHG + C V + P I EDI+ K V +W + +G E+I Y +
Sbjct: 8288 NDHGIAKAPCTVSVLDTPGPPINFVFEDIR-KTSVLCKW-EPPLDDG--GSEIINYTLEK 8343
Query: 1610 GNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAG-----TSSVEVTLKVY 1663
+K + D E+ + T + + +L + + A N G S V +
Sbjct: 8344 KDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPF 8403
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDV 1723
P P+ P++ +++ S+ ++W P D+G + Y +EK E ++ W +V +
Sbjct: 8404 GPPDAPDKPIV-EDVTSNSMLVKWNEPKDNGS-PILGYWLEKREVNSTHWSRVNKSLLNA 8461
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALD-VPSXXXXXXXXXXIDNE 1782
+ L E Y+FRV A+N G + S P KTA D + +
Sbjct: 8462 LKANVDGLLEGLTYVFRVCAENAAGPGKF--SPPSDPKTAHDPISPPGPPIPRVTDTSST 8519
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXAR--IQKLSINTTYQFRI 1839
++ + W P NGG I+ Y V+ + G KW + ++++ Y+ R+
Sbjct: 8520 TIELEWEPPAFNGGGEIVGYFVDKQLVGTNKWSRCTEKMIKVRQYTVKEIREGADYKLRV 8579
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N G P +T+ + PP+ + V P G P+
Sbjct: 8580 SAVNAAGEG-PPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPT 8638
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
+ + + ++ G+ E I++ KD + I+A N+ G ++ + R+
Sbjct: 8639 KVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCG----SKFAAARV 8694
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
E VP P L+ + + + +W PE DGG+ + G+ I +D W + +
Sbjct: 8695 EVF-DVPG-PVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQ--PI 8750
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
+ K +I L E Y R+ A+N+ G P+E
Sbjct: 8751 ETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVE 8785
Score = 108 bits (259), Expect = 2e-22
Identities = 77/283 (27%), Positives = 123/283 (43%), Gaps = 11/283 (3%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGK---KWKXXXXXXXXXA-RIQKLSINTT 1834
I SV W P +GGS II+Y +E K + K +W + KL
Sbjct: 8316 IRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKE 8375
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
Y FR+ A N G P S + PP P +V + TS S+ +KW EP+ NG
Sbjct: 8376 YLFRVRAENRFGPGPPCVSKPLVA-KDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNG- 8433
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
SPI Y +E + V W+++ + + ++ + E +FR+ AEN G P +
Sbjct: 8434 SPILGYWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGLTYVFRVCAENAAG---PGKF 8490
Query: 1955 QSVRLEKHATVP-SPPTAPL-EIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM 2012
K A P SPP P+ + S + W P ++GG ++GY + + V
Sbjct: 8491 SPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNK 8550
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLES 2055
W + + ++ ++++ E Y +R+ A N G P E+
Sbjct: 8551 WSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGET 8593
Score = 107 bits (258), Expect = 3e-22
Identities = 105/448 (23%), Positives = 177/448 (39%), Gaps = 41/448 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P V L+ +G +V EC + GYP P +TW+R+ I+ S DFQ+ + +A L+
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF-QSGIARLM 955
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXXXXXXXXAD 627
IRE F ED+G FTC A N AG S++ L V+ + +T D
Sbjct: 956 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRD 1015
Query: 628 IL--------------EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEE 673
++ E P F KP Q + EG ++ C++ P+P + W G
Sbjct: 1016 VVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVP 1075
Query: 674 IVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE 733
+ V+ V+ +T G YT+V N+ GE S L E +
Sbjct: 1076 LTTGYRYKVSYNKQTGECKLVISMTFAD--DAGEYTIVVRNKHGETSASASL---LEEAD 1130
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
+++ + M+ + + + VG P + + K + T++
Sbjct: 1131 YELLMKSQQEMLYQTQVTAFVQEPEVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVV 1190
Query: 794 PKKVKDEGVYTLKAENS--EGIAETSAVITVEEPTEENAEPPLFIN-------------R 838
V+D+ + E + I T+EE EE+ E + ++ R
Sbjct: 1191 RTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDLR 1250
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF--DGENIELVITNVD 896
+ + E + +++ P+P I WY++ + I E +F DG L I V
Sbjct: 1251 IKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVL 1309
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTID 924
E D G Y ASN G + ++ ++
Sbjct: 1310 PE-DEGIYTAFASNIKGNAICSGKLYVE 1336
Score = 107 bits (258), Expect = 3e-22
Identities = 80/287 (27%), Positives = 127/287 (44%), Gaps = 12/287 (4%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXA-RIQKLSINTTYQ 1836
+ ES ++W + GG+ I +Y VE ++ G W+ ++ L+ Y
Sbjct: 22256 VSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYS 22315
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
FR+ + N G S P S I PPS P V ++ +++++W EP +GGS
Sbjct: 22316 FRVSSENRFGVSKPLESAP-IIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSK 22374
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQ 1955
I Y +E K W K V + + + E E FR A N GVS +E S+
Sbjct: 22375 IIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASR 22434
Query: 1956 SVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKT---M 2012
+ + P P E+ V + V W P +DGG+ ++GY I + V++
Sbjct: 22435 PIMAQNPVDAPGRP----EVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGR 22490
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG-LSEPLESDEP 2058
W++ V+ F + LSE TY R+ A+N G +S+ ES P
Sbjct: 22491 WLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGP 22537
Score = 104 bits (249), Expect = 4e-21
Identities = 81/313 (25%), Positives = 140/313 (44%), Gaps = 19/313 (6%)
Query: 523 DGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G V++ C++E Y + Q+TW+ ++ S+ +++ Y+D VA L ++++ D GT+
Sbjct: 25084 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYED-GVAILYVKDITKLDDGTY 25142
Query: 582 TCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
C N G SS EL V+ + D+ T+ +LE PP F+
Sbjct: 25143 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMR---LLER-PPEFTLP 25198
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHMYCSVLKIT 698
+ G ++ + PEP + W G++I P D + ESD +Y L I
Sbjct: 25199 LYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLY--QLTIN 25256
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV-----RQGESVI 753
+V + YTVVA N+ GE S L + + P+ ++ ++G+SV
Sbjct: 25257 SVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVC 25316
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYTLKAENS 810
+V G P PT+ W K+ +P+ P +G + ++ +D G Y + A N+
Sbjct: 25317 FEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNT 25376
Query: 811 EGIAETSAVITVE 823
G A + VE
Sbjct: 25377 AGSTSCQAHLQVE 25389
Score = 104 bits (249), Expect = 4e-21
Identities = 172/833 (20%), Positives = 327/833 (39%), Gaps = 71/833 (8%)
Query: 736 QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK 795
+++ +SM V +GES S G P PT+TW + + + T + +
Sbjct: 26065 RILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEIS 26124
Query: 796 KVK--DEGVYTLKAENSEGIAETSAVITVEEP--TEENAEPPLFINRFQEITVKEKGTIK 851
V+ DEG Y++ ENSEG E +T+++ TE+ P + + E VK +K
Sbjct: 26125 SVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRV-KSPEPRVKSPEAVK 26183
Query: 852 LVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNS 911
RV ++P PS + + +SP+ET + E ++ + + +I K AS
Sbjct: 26184 SPKRV-KSPEPS-----HPKAVSPTET--KPTPREKVQHLPVSAPPKITQF-LKAEASKE 26234
Query: 912 AGKSSHGARVTI-DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGM 970
K + ++ ++VT+ K +K E + T K + + G
Sbjct: 26235 IAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQ---FHYSADGTYELKINNLTESDQGE 26291
Query: 971 DHREIIQEGRXXXXXXXXXXXXDVGVIKCIVK-------DQETSTMLVVKETIPE----- 1018
EI EG + + + K DQ+T+ V ++T P+
Sbjct: 26292 YVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPI 26351
Query: 1019 -----FIRKLQDFEVKEKDVAILEVEINSETADV-VWERDGEII-KPKKNKYDFEKRGHI 1071
+ LQD V VA V+ E +W +DG+ I + K K +K G
Sbjct: 26352 SSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFF 26411
Query: 1072 RKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELT 1131
L I T D G Y+C +++ + + + +L + I + QKV+ + T EI
Sbjct: 26412 --LEIHKTDTSDSGLYTCTVKNSAGSVSSSC-KLTIKAIKDTEAQKVS--TQKTSEITPQ 26466
Query: 1132 KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY--SCEVGNSKCTAI- 1188
K A+V+ ++ S I+++ ++KL + + +A + S EV S T++
Sbjct: 26467 K-KAVVQEEISQKALR-SEEIKMSEAKSQEKLALKE----EASKVLISEEVKKSAATSLE 26520
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDE------------TLDVTWYKKKSVI 1236
++ I T + E + A A+ T +E DV W +
Sbjct: 26521 KSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVEL 26580
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-----VEFPPKIV 1291
++E++ +TL I++ + D+ TC+ + K + ++ + P +
Sbjct: 26581 TNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFI 26640
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
R I G +V + P P EW N+ I + S SL I+
Sbjct: 26641 SQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNAS 26700
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+D+G Y ++ +N G ++ +L P + +L S ++ + +
Sbjct: 26701 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLR-TSGDTSLQGSFSSQSVQMS 26759
Query: 1412 IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
+ ++ S+ + S Q++ + + + + IS+ ++
Sbjct: 26760 ASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESST 26819
Query: 1472 KVIKETKIQS--PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ + I+ P +E +I+ + + + + C F G P P+VTW G+K+
Sbjct: 26820 SKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI 26872
Score = 98.3 bits (234), Expect = 3e-19
Identities = 107/437 (24%), Positives = 182/437 (41%), Gaps = 33/437 (7%)
Query: 1046 DVVWERD-GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT--AEVTV 1102
++ W R+ GE +K EK + +L I N +D G+Y L + S + A VTV
Sbjct: 17558 EITWSREEGEFT----DKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTV 17613
Query: 1103 VELP-PEIITRLQNQKVNKGNK-ATFEIELTKGDALVR-WFKDGSEIQFSNHIQLTIDGK 1159
L P L ++V K + +E + G A V+ + D E + ++
Sbjct: 17614 KVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCS 17673
Query: 1160 KQKLK--------IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPAN 1211
K K IY + E+ V A+ E PS + L + +
Sbjct: 17674 KTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDV----SQ 17729
Query: 1212 TDAYLTVEIP--DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
T A L E P D V Y + + TEK++++++ K ++ + + ++
Sbjct: 17730 TSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVK 17789
Query: 1270 LLDAKSTTKLKVEVVEFPPKIVDYE-------REYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
+ K + +V V K + + Y I+ G D+ + + P+PN W+
Sbjct: 17790 AYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWV 17849
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
+ + +K+ + S L IK+ D G Y + N+ G A ++V +L+KP
Sbjct: 17850 KDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPG 17909
Query: 1383 PP-GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTSI 1440
PP G E+ + + I W+ P TG I Y+VE ++ TT W V + +T I
Sbjct: 17910 PPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKI 17969
Query: 1441 QNLKTNSSYRFRAYAVN 1457
LKT + Y+FR +A N
Sbjct: 17970 TKLKTGTEYQFRIFAEN 17986
Score = 95.5 bits (227), Expect = 2e-18
Identities = 60/204 (29%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 713 VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN 772
++R ++ I K+ +GE P + + +K + + GE+ LS Q+VG P P I W +
Sbjct: 24016 LSRPRRTAMSIKTKLTSGEA--PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFG 24073
Query: 773 KPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
K + + SDG TH++T++ ++ +DEGVYT A N G ETS+ + ++ + +
Sbjct: 24074 KELIQSRKYKMSSDGRTHTLTVMTEEQ-EDEGVYTCIATNEVGEVETSSKLLLQATPQFH 24132
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE 889
PL + + T++L PVP++TW+ +++ SE IT
Sbjct: 24133 PGYPLKEKYYGAVG----STLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTH 24188
Query: 890 LVITNVDSEIDSGDYKCVASNSAG 913
LV+ NV + +G YK SN G
Sbjct: 24189 LVMKNVQRKTHAGKYKVQLSNVFG 24212
Score = 90.2 bits (214), Expect = 7e-17
Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA--LP----TKSDGDT 786
+ P +PL+S++V +G + A + G P P ++W ++ + + LP + SDG
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
+TI K + G Y+LKA N G A ++A + V+ T PP F+ R Q +TV++
Sbjct: 64 -KLTIPAVTKA-NSGRYSLKATNGSGQATSTAELLVKAETA----PPNFVQRLQSMTVRQ 117
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
++L RVT P P + +YR+ I S + +G+ L+I E DSG Y
Sbjct: 118 GSQVRLQVRVTGIPNPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPE-DSGTYSV 176
Query: 907 VASNSAGKSSHGARVTIDVEK 927
A+NS G+++ A + + E+
Sbjct: 177 NATNSVGRATSTAELLVQGEE 197
Score = 89.8 bits (213), Expect = 9e-17
Identities = 58/201 (28%), Positives = 100/201 (49%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTH 787
+P V++P+ S +G + +VVG P P W + + + + K DG T
Sbjct: 1410 KPVFVLKPV-SFKCLEGANCRFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG-TQ 1467
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
S+ I+ P D G +T+ A+N G + S ++TVE E+ P+F+ + + + +KE
Sbjct: 1468 SLIIV-PATPSDSGEWTVVAQNRAGRSSISVILTVE--AVEHQVKPMFVEKLKNVNIKEG 1524
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEI--DSGDYK 905
+++ R T NP P I W +N++II P + +G E + +DS + DS Y
Sbjct: 1525 SRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL-KIDSTVSQDSAWYT 1583
Query: 906 CVASNSAGKSSHGARVTIDVE 926
A N AG+ + +V ++VE
Sbjct: 1584 ATAINKAGRDTTRCKVNVEVE 1604
Score = 89.0 bits (211), Expect = 2e-16
Identities = 54/175 (30%), Positives = 80/175 (45%), Gaps = 9/175 (5%)
Query: 1298 RIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK----CKHTKPSIDSKSAS--LTIKKVE 1351
++K G V + D P P EW N +I+K + TK + A L+I K
Sbjct: 8912 KVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAV 8971
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
D G Y + N G ++V + D+PSPP + +I + S + WD P + G S
Sbjct: 8972 REDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSE 9031
Query: 1412 IIYYVVEYQEID--TTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEVDISD 1463
I +YV++ ++ EW V N + + I L N Y FR AVN+ ISD
Sbjct: 9032 ITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISD 9086
Score = 88.6 bits (210), Expect = 2e-16
Identities = 61/202 (30%), Positives = 99/202 (49%), Gaps = 9/202 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYC 692
PTF++ ++ V EGS E + P P+++W G+ I V I SD
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR--- 62
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L I V K G Y++ A N G+A+ L +K E PP ++ L+SM VRQG V
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-ETAPPNFVQRLQSMTVRQGSQV 121
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L +V G P P + + ++ +++ +GD +S+ I + +D G Y++ A N
Sbjct: 122 RLQVRVTGIPNPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYP-EDSGTYSVNATN 180
Query: 810 SEGIAETSAVITVEEPTEENAE 831
S G A ++A + V+ E A+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAK 202
Score = 87.0 bits (206), Expect = 7e-16
Identities = 61/211 (28%), Positives = 96/211 (45%), Gaps = 9/211 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F KP + EG++ + ++V P P+ W G++IV D V I+ D
Sbjct: 1411 PVFVLKPVSFKCLEGANCRFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1470
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE-PPQVIEPLKSMIVRQGESV 752
++ T G +TVVA NR G +S+ ++L ++ E + P +E LK++ +++G +
Sbjct: 1471 IVPAT---PSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRL 1527
Query: 753 ILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKV-KDEGVYTLKAE 808
+ + GNP P I W KN+ P K + +G + V +D YT A
Sbjct: 1528 EMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAI 1587
Query: 809 NSEGIAETSAVITVE-EPTEENAEPPLFINR 838
N G T + VE E E E L I R
Sbjct: 1588 NKAGRDTTRCKVNVEVEFAEPEPERKLIIPR 1618
Score = 87.0 bits (206), Expect = 7e-16
Identities = 109/506 (21%), Positives = 193/506 (38%), Gaps = 39/506 (7%)
Query: 598 LIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
++ +A L D G+ + + + L + P K V E +++ C
Sbjct: 6112 VVKDATLQDMGTYVVMVGAARAAAHLTVIEKLRIVVPL-----KDTRVKEQQEVVFNCE- 6165
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
V W F+ EE + D + + ++ D+ +Y L+I + + Y V N G
Sbjct: 6166 VNTEGAKAKW-FRNEEAIFDSSKYIILQKDL-VY--TLRIRDAHLDDQANYNVSLTNHRG 6221
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-- 775
E I E+E +++EPLK + + +SV + V T+ W KN + V
Sbjct: 6222 ENVKSAANLIV--EEEDLRIVEPLKDIETMEKKSVTFWCK-VNRLNVTLKWTKNGEEVPF 6278
Query: 776 -KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPL 834
+ + D H +TI K DEG Y + A + +AE ++ +E PTE
Sbjct: 6279 DNRVSYRVDKYKHMLTI-KDCGFPDEGEYIVTAGQDKSVAE---LLIIEAPTE------- 6327
Query: 835 FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITN 894
F+ ++ TV E +++R ++ WYRN I + DG L+I +
Sbjct: 6328 FVEHLEDQTVTEFDDAVFSCQLSREKA-NVKWYRNGREIKEGKKYKFEKDGSIHRLIIKD 6386
Query: 895 VDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH 954
+ D +Y C + + AR+ ++ V ++ Q E V L
Sbjct: 6387 CRLD-DECEYACGVEDRKSR----ARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNKD 6441
Query: 955 TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKE 1014
V +W N + D +++ EG+ D G + I KD+E L +
Sbjct: 6442 KVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLEL-A 6500
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
P+ QD V + V ++ A+ W ++ E + K +
Sbjct: 6501 AAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTK----TIDTTAEQTS 6556
Query: 1074 LYIRNTSVHDEGEYSCILRDESCTAE 1099
I D+G Y +L+++ AE
Sbjct: 6557 FRILEAKKGDKGRYKIVLQNKHGKAE 6582
Score = 86.6 bits (205), Expect = 9e-16
Identities = 65/248 (26%), Positives = 109/248 (43%), Gaps = 16/248 (6%)
Query: 1219 EIPDETLDVTWYKKKSVIEDTEK-FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
+I D + D W + + + K FT+ S + + R C ++ + A+
Sbjct: 12041 KIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQ----VGIGRPAELKE 12096
Query: 1278 KLKVEVVEFPPKIVDYEREYR----IKRGSDVTLLVDYQAFPQPNDEW--IVNSKIIKKC 1331
+K + + PP+I D + R ++ G + L + P P W + +++K
Sbjct: 12097 AIKPKEILEPPEI-DLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRK- 12154
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
+ + A L I D+G Y L L N G V +NV +LD P P + +
Sbjct: 12155 --GQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSD 12212
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYR 1450
+ +S ++ W PEN G S + +Y+VE +E D W +V + KT + NL + Y
Sbjct: 12213 VTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYY 12272
Query: 1451 FRAYAVNE 1458
FR AVNE
Sbjct: 12273 FRVTAVNE 12280
Score = 86.2 bits (204), Expect = 1e-15
Identities = 76/300 (25%), Positives = 127/300 (42%), Gaps = 31/300 (10%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +++L+P G +F + G P+P+I+W+++ ++ + +D TL+
Sbjct: 3193 PQVLQELQPVTVQSGKPARFCAMISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEY-TLL 3251
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP-LSDHGSEMTVXXXXXXXXXXXXADI 628
+ E FPEDA +TC AKN G A+++ L VE P + EM V
Sbjct: 3252 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPV--------------- 3296
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
PP + EG +CR V+ + ++W K ++I P + D
Sbjct: 3297 ---YPPAIITPLQDTVTSEGQPARFQCR-VSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT 3352
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ L+I EGTYT VA N G+ S L ++ E + IE M +++
Sbjct: 3353 YQ----LEIAEAYPEDEGTYTFVANNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKE 3408
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKAL------PTKSDGDTHSITILKPKKVKDEGV 802
S LSA+ G + K N+ ++ L PTK D + + K+V + +
Sbjct: 3409 FSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTGPIFIKEVSNADI 3468
Score = 83.0 bits (196), Expect = 1e-14
Identities = 51/198 (25%), Positives = 92/198 (46%), Gaps = 3/198 (1%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
++ G +V L + Y+ P+P+ W+ + +K+ + + S +L+IK + G Y
Sbjct: 21078 VRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKY 21137
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKP-NILEIDSSSINICWDEPENTGNSTIIYYVV 1417
+ L+N V + V L PS P P EI + S+ + WD PE+ G I Y +
Sbjct: 21138 TVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITCYSI 21197
Query: 1418 EYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
E +E T W V ++ +T + NL ++ Y+FR A N +S + +
Sbjct: 21198 EKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVSQPL-VSSIIVAKHQ 21256
Query: 1477 TKIQSPTVEKPLKNITTE 1494
+I P + + N+T++
Sbjct: 21257 FRIPGPPGKPVIYNVTSD 21274
Score = 81.0 bits (191), Expect = 4e-14
Identities = 149/701 (21%), Positives = 259/701 (36%), Gaps = 54/701 (7%)
Query: 639 KPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKIT 698
KP++ V EG C P P + WL KG+ + V Y S +I+
Sbjct: 26069 KPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTK----YKSTFEIS 26124
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQV 758
+V+ EG Y+VV N EG+ L I+ V P + V+ E + S +
Sbjct: 26125 SVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPR---VKSPEPRVKSPEA 26181
Query: 759 VGNPR----PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V +P+ P + K P + PT + H + + P K+ LKAE S+ IA
Sbjct: 26182 VKSPKRVKSPEPSHPKAVSPTETKPTPREKVQH-LPVSAPPKI----TQFLKAEASKEIA 26236
Query: 815 E-----TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKL-VARVTRNPVPSITWYR 868
+ S+V+ +E T L N + GT +L + +T +
Sbjct: 26237 KLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEI 26296
Query: 869 NNEIISPSETITQNFDGENIELVITNVD--SEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+ E S+T Q F G+ + + V SE D K S K+ A I
Sbjct: 26297 SGE-GGTSKTNLQ-FMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPIS-S 26353
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHTVSTK-WYHNKKEISGMDHREIIQEGRXXXXX 985
K V LQ + + + T T W + K I+ ++ ++
Sbjct: 26354 KPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLE 26413
Query: 986 XXXXXXXDVGVIKCIVKDQETS-------TMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
D G+ C VK+ S T+ +K+T + + + E+ + A+++
Sbjct: 26414 IHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQE 26473
Query: 1039 EINSETADVVWERDGEI-IKPKKNKYDFEKRGHIRKLYIR---NTSVHDEGEYSCILRDE 1094
EI+ + R EI + K++ + K+ I S E S + +
Sbjct: 26474 EISQKAL-----RSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEI 26528
Query: 1095 SCTAEVT-VVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
+ T++ + V EI +N+G + + + G V+W +G E+ S +
Sbjct: 26529 TKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIA-GATDVKWVLNGVELTNSEEYR 26587
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTV--EEPSINFTLRLPEFIL 1207
+ G Q L I D G +C + G KC LT+ E + P
Sbjct: 26588 YGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQN 26647
Query: 1208 VPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
+ + T EI E + ++ W+K I + ++ +L IR + D +Y
Sbjct: 26648 INEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 26707
Query: 1267 TCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
T + + ++ P + + RE ++ D +L
Sbjct: 26708 TIKAKNFRGQCSATASLMVL-PLVEEPSREVVLRTSGDTSL 26747
Score = 78.6 bits (185), Expect = 2e-13
Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 6/187 (3%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK--SASLTIKKVENTDAG 1356
+K G + L + P P W + + + ID++ S+ ++ K + +D G
Sbjct: 11716 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 11775
Query: 1357 IYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
Y + N G V +LDKP P I+++ S +CWD PE+ G I Y+
Sbjct: 11776 KYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYI 11835
Query: 1417 VEYQEIDTTEWISVKNITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+E E W + T T++ L + Y FR A N++ TE VI
Sbjct: 11836 LEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKI---GTGPPTESKPVIA 11892
Query: 1476 ETKIQSP 1482
+TK P
Sbjct: 11893 KTKYDKP 11899
Score = 78.2 bits (184), Expect = 3e-13
Identities = 64/245 (26%), Positives = 104/245 (42%), Gaps = 31/245 (12%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
E+ P+FV K +G+ +F+ +V G P P+ WF I ++ +D
Sbjct: 1406 ERLYKPVFVLKPVSFKCLEGANCRFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1465
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I P D+G +T VA+N AG +S + L VEA
Sbjct: 1466 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA---------------------- 1503
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
+ + P F +K K + EGS + ++ R P PDI WL + IVP + + I
Sbjct: 1504 ---VEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRI 1560
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + LKI + YT A+N+ G + + ++ EP EP + +
Sbjct: 1561 EGTKGE--AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP----EPERKL 1614
Query: 745 IVRQG 749
I+ +G
Sbjct: 1615 IIPRG 1619
Score = 78.2 bits (184), Expect = 3e-13
Identities = 94/421 (22%), Positives = 164/421 (38%), Gaps = 35/421 (8%)
Query: 1074 LYIRNTSVHDEGEYSCILRDESC----TAEVTVVELPPEIITR-LQNQKVNKGNKAT-FE 1127
+ I+N +G YS + ++E+ T V V+++P + T L + N+ K T F
Sbjct: 10083 MVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFS 10142
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
E G + + + E +T +Q + L Y +
Sbjct: 10143 PEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQG--LIQGKAYFFRIAAENSIG 10200
Query: 1188 ILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW-------------YKKKS 1234
+ E S +R P I VP + E+ T+ +TW Y +S
Sbjct: 10201 MGPFVETSEALVIREP--ITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLES 10258
Query: 1235 VIEDTEKFTLISD--VKKRTLIIRKCTEDDQCEYTCVLLDAKS-------TTKLKVEVVE 1285
+ TEKF +++ + R ++ E D EY ++ T + +
Sbjct: 10259 RLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDEL 10318
Query: 1286 FPPKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
PP + +D+ + I+ G L Y P+P W + + + T + +
Sbjct: 10319 APPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLA 10378
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDE 1403
L K + +D+G Y + +EN+ G V ++D P PP G + E+ + I W
Sbjct: 10379 LEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDHPGPPVGPVSFDEVTKDYMVISWKP 10438
Query: 1404 PENTGNSTIIYYVVEYQEIDTTEWISVKNIT-KTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
P + G S I Y++E +E+ W+ V + + KT + L Y FR +A N IS
Sbjct: 10439 PLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGIS 10498
Query: 1463 D 1463
D
Sbjct: 10499 D 10499
Score = 76.6 bits (180), Expect = 9e-13
Identities = 64/231 (27%), Positives = 104/231 (45%), Gaps = 35/231 (15%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ--DFQMYYDDDN 564
+ AP F + L+ +GST FE + G+P P+++WFR +I S Q+ + D
Sbjct: 3 TQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
A L I V ++G ++ A N +G A+ST +E+ V
Sbjct: 63 -AKLTIPAVTKANSGRYSLKATNGSGQATST-------------AELLVKA--------- 99
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
E PP F ++ ++ V +GS + L+ R+ IP P + + G EI + ++
Sbjct: 100 -----ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPNPVVKFYRDGAEIQSSLDFQISQ 154
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP 735
E D++ L I GTY+V A N G A+ L ++ GE+E P
Sbjct: 155 EGDLYS----LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ-GEEEVP 200
Score = 76.2 bits (179), Expect = 1e-12
Identities = 55/212 (25%), Positives = 94/212 (44%), Gaps = 9/212 (4%)
Query: 1288 PKIVDYEREYR----IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
P IV++ EY IK G + + Q P P W + I+K + + + S
Sbjct: 21458 PPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITNVLGST 21517
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP-PGKPNILEIDSSSINICWD 1402
SL ++ G+Y + +N G A E+ V + D P G I + + WD
Sbjct: 21518 SLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWD 21577
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQ--TSIQNLKTNSSYRFRAYAVNEVD 1460
P N G + I +Y++E +E W +++ + Q T+I+ + N Y+FR AVN+
Sbjct: 21578 APLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGN-EYQFRVSAVNKFG 21636
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNIT 1492
+ ++ I+ T +P + +P NIT
Sbjct: 21637 VGRPLDSDPVVAQIQYTVPDAPGIPEP-SNIT 21667
Score = 74.9 bits (176), Expect = 3e-12
Identities = 123/586 (20%), Positives = 228/586 (38%), Gaps = 62/586 (10%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
+K K V E EC + P + WL G EI E + ++ +H L
Sbjct: 2839 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ----LI 2893
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
I N YT V N + A+L + P + LK + + +++
Sbjct: 2894 IMNTSTEDSAEYTFVCGNDQVSATLTVT---------PIMITSMLKDINAEEKDTITFEV 2944
Query: 757 QVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
V + W KN +K+ ++ THS+ I + D YT A G
Sbjct: 2945 -TVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNI-RNVHFGDAADYTFVA----GK 2998
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A ++A + VE E F ++I V EK V+ P ++ W ++++ +
Sbjct: 2999 ATSTATLYVEARHIE------FRKHIKDIKVLEKKRAMFECEVSE-PDITVQWMKDDQEL 3051
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ I + L+I + D+G Y VA + A++ ++ V ++
Sbjct: 3052 QITDRIKIQKEKYVHRLLIPSTRMS-DAGKYTVVAGGNVST----AKLFVEGRDVR-IRS 3105
Query: 934 LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGM--DHREIIQEGRXXXXXXXXXX 990
++K + E + ++E + + V WY + EI+ + + + E R
Sbjct: 3106 IKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETR 3165
Query: 991 XXDVGVIKCIV-KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV- 1048
D G + +++ + T+ V P+ +++LQ V+ A I+ +
Sbjct: 3166 QSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAMISGRPQPKIS 3225
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE------SCTAEVTV 1102
W ++ +++ K F G L + D Y+C +++ S + V V
Sbjct: 3226 WYKEEQLLSTGF-KCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEV 3284
Query: 1103 VEL----------PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
E+ PP IIT LQ+ ++G A F+ ++ D V W+ +I+ S
Sbjct: 3285 PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFF 3344
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEP 1194
++T +L+I + +D G Y+ VG TA L++E P
Sbjct: 3345 RMTQFEDTYQLEIAEAYPEDEGTYTFVANNAVGQVSSTANLSLEAP 3390
Score = 74.5 bits (175), Expect = 4e-12
Identities = 85/375 (22%), Positives = 162/375 (43%), Gaps = 33/375 (8%)
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ--LTIDG--KKQKLKIYDCDLDDAGEY 1176
G+K T I K RW K F+N ++ T+ G + Q+ + + AG +
Sbjct: 18134 GSKITGYIVEKKDLPDGRWMK----ASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNF 18189
Query: 1177 SCEVGNSKC-TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTWYKKKS 1234
S +S TA ++ P+ + + + I+V A L +I + + DV W K
Sbjct: 18190 SEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGK 18249
Query: 1235 VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDY 1293
+E+T + + S ++K TL+++ C D +Y L + T + + V K++D
Sbjct: 18250 ELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITV-----KVLDR 18304
Query: 1294 --EREYRIKRGSDVTLLVDYQAFPQPNDE-------WIVNSKIIKKCKHTKPSIDSKSAS 1344
E +K + VT Y A+ P + +I+ + + T+ S + ++ +
Sbjct: 18305 PGSPEGPLKV-TGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALN 18363
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHAD-VEMN-VTILDK---PSPPGKPNILEIDSSSINI 1399
+ K+ + I+++ N G + +E VT + P PP P + I S+ +
Sbjct: 18364 YKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVV 18423
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKTQTSIQNLKTNSSYRFRAYAVN 1457
W P + G + I Y++E ++ + W + K +T + + L SY FR A N
Sbjct: 18424 TWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAEN 18483
Query: 1458 EVDISDASETTEYYK 1472
+ + SE + +Y+
Sbjct: 18484 AAGVGEPSEPSVFYR 18498
Score = 73.7 bits (173), Expect = 6e-12
Identities = 41/112 (36%), Positives = 60/112 (53%), Gaps = 2/112 (1%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
++P P E P + L+ T +G +F+C+V G +++W+ + IKPS
Sbjct: 3283 EVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPS 3341
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ F+M +D L I E +PED GT+T VA NA G SST L +EAP S
Sbjct: 3342 RFFRMTQFEDTYQ-LEIAEAYPEDEGTYTFVANNAVGQVSSTANLSLEAPES 3392
Score = 72.9 bits (171), Expect = 1e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 1/96 (1%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
++ P FV++L+ GS V+ + +V G P P + ++R A I+ S DFQ+ + D +
Sbjct: 100 ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPNPVVKFYRDGAEIQSSLDFQISQEGD-L 158
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+L+I E +PED+GT++ A N+ G A+ST EL+V+
Sbjct: 159 YSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 72.9 bits (171), Expect = 1e-11
Identities = 54/205 (26%), Positives = 92/205 (44%), Gaps = 13/205 (6%)
Query: 476 DENNYTQYLQ-KKLNEKIDKL---PVFE-KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFE 530
+E ++ LQ K+NE ++ L PV+ K SE++ PIF++++ G
Sbjct: 3418 EEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTGPIFIKEVSNADISMGDVATLS 3477
Query: 531 CQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
V G P+P+I WF ++ PS D++ +D D+ +L+I ED G +TC+A N G
Sbjct: 3478 VTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDD-HSLIILFTKLEDEGEYTCMASNDYG 3536
Query: 591 FASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEG-IPPTFSKKPKAQYVDEGS 649
+ L + + H T + L G PP F K+ K +G
Sbjct: 3537 KTICSAYLKINSKGEGHKDTET------ESAVAKSLEKLGGPCPPHFLKELKPIRCAQGL 3590
Query: 650 DILLECRLVAIPEPDIAWLFKGEEI 674
+ E +V P P + W + +++
Sbjct: 3591 PAIFEYTVVGEPAPTVTWFKENKQL 3615
Score = 72.9 bits (171), Expect = 1e-11
Identities = 64/217 (29%), Positives = 88/217 (40%), Gaps = 28/217 (12%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
EG P F K+ + G L ++ IP+P I W F G + P + + D H
Sbjct: 3453 EGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDH 3512
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT---GEKE------------- 733
L I K EG YT +A N G+ LKI + G K+
Sbjct: 3513 S----LIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEK 3568
Query: 734 -----PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV--KALPTKSDGDT 786
PP ++ LK + QG I VVG P PT+TW K NK + T
Sbjct: 3569 LGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPN 3628
Query: 787 HSIT-ILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
S T I+ + +D G+Y KAEN G + +A + V
Sbjct: 3629 GSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3665
Score = 72.1 bits (169), Expect = 2e-11
Identities = 64/298 (21%), Positives = 122/298 (40%), Gaps = 11/298 (3%)
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTL 1244
TA VE P I+ + + I+V A L ++ + L + W + IE++ + +
Sbjct: 17118 TAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEI 17177
Query: 1245 ISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFP-PKIVDYEREYRIKR 1301
+ K LI++ D +Y + + + V+V++ P P +
Sbjct: 17178 KNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSE 17237
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
+T Q ++V + + T + + + SL + K+ + ++++
Sbjct: 17238 KCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIM 17297
Query: 1362 LENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
N G + + +L K P PP + I S+ +CW+ P++ G S II Y+
Sbjct: 17298 AVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYI 17357
Query: 1417 VEYQEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
VE ++ WI + + IT + + L + Y FR A N + + S T YYK
Sbjct: 17358 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYK 17415
Score = 71.7 bits (168), Expect = 3e-11
Identities = 76/297 (25%), Positives = 114/297 (38%), Gaps = 30/297 (10%)
Query: 673 EIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE--ASLPIVLKIKTG 730
E + E I IE +M + S + + +N E + P+
Sbjct: 3391 ESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYPTKFDS 3450
Query: 731 EKEP--PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN---KPVKALPTKSDGD 785
EKE P I+ + + + G+ LS V+G P+P I W N P DGD
Sbjct: 3451 EKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGD 3510
Query: 786 THSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE-------------- 831
HS+ IL K++DEG YT A N G SA + + E + +
Sbjct: 3511 DHSLIILF-TKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKL 3569
Query: 832 ----PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS--ETITQNFDG 885
PP F+ + I + V P P++TW++ N+ + S TI N +G
Sbjct: 3570 GGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNG 3629
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
I N DSG Y C A N G+S+ A + + +E K+ T E
Sbjct: 3630 SG--TFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAKSTPE 3684
Score = 71.7 bits (168), Expect = 3e-11
Identities = 72/330 (21%), Positives = 133/330 (40%), Gaps = 40/330 (12%)
Query: 646 DEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+EG + C++ + + W F ++ E + E + ++L + ++ K
Sbjct: 25083 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGV----AILYVKDITKLD 25138
Query: 705 EGTYTVVAVNREGEASLPIVLKIK------------TGEK------------EPPQVIEP 740
+GTY VN GE S L +K T +K PP+ P
Sbjct: 25139 DGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLP 25198
Query: 741 LKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV------KALPTKSDGDTHSITILKP 794
L + GE+V + +P P +TW K+ + + K +SD + +TI
Sbjct: 25199 LYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTI-NS 25257
Query: 795 KKVKDEGVYTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKL 852
D+ YT+ A N E + +T+ P ++ P+F +E ++
Sbjct: 25258 VTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCF 25317
Query: 853 VARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSA 912
RV+ P P++ W ++ + +S I +G + + D+G Y+ A+N+A
Sbjct: 25318 EIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTA 25377
Query: 913 GKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
G +S + + VE++ + K KS E E
Sbjct: 25378 GSTS--CQAHLQVERLRYKKQEFKSKEEHE 25405
Score = 69.3 bits (162), Expect = 1e-10
Identities = 54/172 (31%), Positives = 90/172 (52%), Gaps = 16/172 (9%)
Query: 678 ENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---P 734
E S+ ES + C+ + +T + QE + V A N +G++ P VL + K+
Sbjct: 17760 EKWSIVAESKV---CNAV-VTGLSSGQEYQFRVKAYNEKGKSD-PRVLGVPVIAKDLTIQ 17814
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P + P + ++ GE + + V+G PRP I+W K+ +P+K + +T + T+L
Sbjct: 17815 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHI 17874
Query: 795 KK-VKDE-GVYTLKAENSEGIA-ETSAVITVEEPTEENAEPPLFINRFQEIT 843
K+ KD+ G YT+ A NS G A E +VI +E+P PP+ RF E++
Sbjct: 17875 KEGNKDDFGKYTVTATNSAGTATENLSVIVLEKP-----GPPVGPVRFDEVS 17921
Score = 68.5 bits (160), Expect = 2e-10
Identities = 40/163 (24%), Positives = 79/163 (48%), Gaps = 12/163 (7%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASL-----TIKKVENTDAGIYKLRLENNCGHA 1369
P+ + + + I++KC+ + + SA++ T+ ++ + I+++R EN G
Sbjct: 11823 PEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGTG 11882
Query: 1370 DVEMNVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
+ ++ DKP P P + ++ + + W+ PE G +I Y +E +E +
Sbjct: 11883 PPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHS 11942
Query: 1425 TEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
T W+ V I + + +QNL + Y+FR A NE+ I + S
Sbjct: 11943 TRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPS 11985
Score = 68.5 bits (160), Expect = 2e-10
Identities = 75/299 (25%), Positives = 130/299 (43%), Gaps = 15/299 (5%)
Query: 319 EAAKVKKQVF--VPPKLPDVEKTELEQPLFSYEDIVESK-KDENEIIQEKQTLEELPKED 375
EA KV Q + P+ V + E+ Q E+I S+ K + ++ +++ + L E+
Sbjct: 26451 EAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEE 26510
Query: 376 VPEQYTITPRKSSAQKIDEIVDEVTIKKRLNP-FEIFYTPVEVRCGDTVFAVYSYVAETD 434
V + + KS + + + + R + + F T + + G + + TD
Sbjct: 26511 VKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATD 26570
Query: 435 EAINLVEGERLYILDTSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDK 494
++ G L T+++++ Y + A + DE T K E I K
Sbjct: 26571 VKW-VLNGVEL----TNSEEYRYGVSGSDQTLTIKQASH-RDEGILTCI--SKTKEGIVK 26622
Query: 495 LPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ 554
++ S+E S AP F+ + R ++ +G V F C++ G P P+I WF+ I S
Sbjct: 26623 CQ-YDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISS 26681
Query: 555 DFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTV 613
+ + NV +L IR D+G +T AKN G S+T L+V PL + S V
Sbjct: 26682 NVSI-SRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV-LPLVEEPSREVV 26738
Score = 67.3 bits (157), Expect = 6e-10
Identities = 62/257 (24%), Positives = 110/257 (42%), Gaps = 16/257 (6%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEF 1286
++W K ++++E K TL I+ ++ +YT +L +A + + V+
Sbjct: 21098 ISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITL 21157
Query: 1287 -PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK--CKHTKPSIDSKSA 1343
PP + + V L D P+ N + I+K T + S
Sbjct: 21158 GPPSKPKGPIRFDEIKADSVILSWD---VPEDNGGGEITCYSIEKRETSQTNWKMVCSSV 21214
Query: 1344 SLTIKKVEN--TDAGI-YKLRLENNCGHADVEMNVTILDK-----PSPPGKPNILEIDSS 1395
+ T KV N DA +++R EN G + ++ I+ K P PPGKP I + S
Sbjct: 21215 ARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSD 21274
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKTQTSIQNLKTNSSYRFRA 1453
+++ WD P G S + + VE +E ++ W ++ I+ + L Y+FR
Sbjct: 21275 GMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRV 21334
Query: 1454 YAVNEVDISDASETTEY 1470
YA N +S S+ +++
Sbjct: 21335 YAENSAGLSSPSDPSKF 21351
Score = 66.5 bits (155), Expect = 1e-09
Identities = 54/185 (29%), Positives = 84/185 (45%), Gaps = 9/185 (4%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNK-YDFEKRGHIRKL 1074
P F + LQ V E A E I+ +V W RDG++I KL
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1075 YIRNTSVHDEGEYSCILRDES----CTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEI 1128
I + + G YS + S TAE+ V PP + RLQ+ V +G++ ++
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 1129 ELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
+T + +V++++DG+EIQ S Q++ +G L I + +D+G YS NS A
Sbjct: 126 RVTGIPNPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 1188 ILTVE 1192
T E
Sbjct: 186 TSTAE 190
Score = 66.1 bits (154), Expect = 1e-09
Identities = 37/104 (35%), Positives = 56/104 (53%), Gaps = 2/104 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE +++ F +++ +G V F C++ GYP P+I W++ IK + +QM +
Sbjct: 1238 SESEAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQ 1297
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE--APL 604
D A+L I V PED G +T A N G A + +L VE APL
Sbjct: 1298 DGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPL 1341
Score = 65.3 bits (152), Expect = 2e-09
Identities = 66/217 (30%), Positives = 98/217 (45%), Gaps = 16/217 (7%)
Query: 1001 VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKK 1060
VK QE L+ KE P L D +E D+ L I + +V W + +++ P
Sbjct: 4228 VKIQEAEGGLI-KEDGPMIHTPLVDTVSEEGDIVHLTTSITN-AKEVNWYFENKLV-PSD 4284
Query: 1061 NKYDFEKRGHIRKLYIRNTSVHD-EGEYSC-ILRDESCTA---EVTVVELPPEIITR-LQ 1114
K+ + + L I + D +GEY C L D TA ++TVV+ +I R ++
Sbjct: 4285 EKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIE 4344
Query: 1115 NQKVNKGNKATFEIELTKG-DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDA 1173
+V G+ A F E+ + +WFK G EI S+ + L+I + D
Sbjct: 4345 PLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDC 4404
Query: 1174 GEYSC----EVGNSKCTAILTVEEPSINFTLR--LPE 1204
GEY+C E G+ CTA LTV P +R LPE
Sbjct: 4405 GEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLPE 4441
Score = 64.9 bits (151), Expect = 3e-09
Identities = 80/400 (20%), Positives = 138/400 (34%), Gaps = 13/400 (3%)
Query: 1282 EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
E + P IV ++ + S V P+P W + K I + K S D
Sbjct: 26349 EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKG 26408
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD-KPSPPGKPNILEIDSSSINIC 1400
L I K + +D+G+Y ++N+ G +TI K + K + + +
Sbjct: 26409 GFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKK 26468
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE-- 1458
E + ++ E + E +++K + +K +++ V+E
Sbjct: 26469 AVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEI 26528
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
S ASE + IK Q E + ++ + GV YR
Sbjct: 26529 TKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRY 26588
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK--PVITIS 1576
G T + CI+ G V+ + + ++
Sbjct: 26589 GVSGSDQTLTIKQASHRDEGILT--------CISKTKEGIVKCQYDLTLSKELSDAPAFI 26640
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELK 1636
++ Q G L T I G P PE+ W+KN + +I+ + I+
Sbjct: 26641 SQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNAS 26700
Query: 1637 RSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
S S KYTI+A N G S +L V +P V++R
Sbjct: 26701 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLR 26740
Score = 64.9 bits (151), Expect = 3e-09
Identities = 84/402 (20%), Positives = 149/402 (37%), Gaps = 60/402 (14%)
Query: 541 ITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ W + S++++ Y + TL I++ D G TC++K G +L +
Sbjct: 26571 VKWVLNGVELTNSEEYR-YGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTL 26629
Query: 601 EAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAI 660
LSD P F +P++Q ++EG ++L C +
Sbjct: 26630 SKELSD--------------------------APAFISQPRSQNINEGQNVLFTCEISGE 26663
Query: 661 PEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEAS 720
P P+I W I N+S++ +++ L+I N G YT+ A N G+ S
Sbjct: 26664 PSPEIEWFKNNLPISISSNVSISRSRNVYS----LEIRNASVSDSGKYTIKAKNFRGQCS 26719
Query: 721 LPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPT 780
L + P V EP + +++R L G+ +K + +
Sbjct: 26720 ATASLMVL------PLVEEPSREVVLRTSGDTSLQ----GSFSSQSVQMSASKQEASFSS 26769
Query: 781 KSDGDTHSITILKPKKVKDEGVYTLKAE----NSEGIAETSAVITVEEPTEENAE----- 831
S S+T +K + + + +++ +S S + +E T + +
Sbjct: 26770 FSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRG 26829
Query: 832 -PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE- 889
PP +I++ E + + T P P +TW I E F EN +
Sbjct: 26830 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQE--QGRFHIENTDD 26887
Query: 890 ---LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
L+I +V + D G Y N G S A V I + +
Sbjct: 26888 LTTLIIMDVQKQ-DGGLYTLSLGNEFGSDS--ATVNIHIRSI 26926
Score = 64.1 bits (149), Expect = 5e-09
Identities = 64/281 (22%), Positives = 113/281 (40%), Gaps = 14/281 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIEL-TKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P I R+++ +V G F + + +K A V+W+ +G E+Q S+ I T L+I
Sbjct: 25877 PRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEI 25936
Query: 1166 YDCDLDDAGEYSCEVGNSKCTA--ILTVEEPSINFTLRLPE--FILVPANTDAYLTVEIP 1221
DC DD+G Y N K A T++ ++T + VP + LT
Sbjct: 25937 LDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELT---R 25993
Query: 1222 DETLDVTWYKKKSVIEDTEKFTLI-SDVKKRTLIIRKCTEDDQCEYTCVLLDAKS----T 1276
E V +KK S +E + + S + + + E L+ KS +
Sbjct: 25994 TEAYAVPSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKS 26053
Query: 1277 TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
T K++ +I+ R + G D P P W+ +++ +
Sbjct: 26054 TTRKIKTT-LAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQV 26112
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ ++ I V+ +D G Y + +EN+ G + E +TI
Sbjct: 26113 TTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTI 26153
Score = 63.7 bits (148), Expect = 7e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 2/110 (1%)
Query: 495 LPVFEKPTSE-EQSM-APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKP 552
+P F+ E SM AP E+++ + GS F +V G P P+ W++ I+
Sbjct: 2015 IPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIER 2074
Query: 553 SQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
S Y+ +DNV LVIR+V ED+ + A N AG SS L+V+A
Sbjct: 2075 SDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2124
Score = 62.9 bits (146), Expect = 1e-08
Identities = 62/302 (20%), Positives = 121/302 (40%), Gaps = 13/302 (4%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVV 1284
V+W+K ++ +++ T+ +D L + K D YT L + +T + V+V+
Sbjct: 7921 VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVI 7980
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P D + K +T P +++ + + + S
Sbjct: 7981 GLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLS 8040
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHAD-VEMNVTIL--DKPSPPGKPNILEIDS---SSIN 1398
T+K + ++++ N G + +E+ ++ D PP P +E+ + ++
Sbjct: 8041 WTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMT 8100
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQT-SIQNLKTNSSYRFRAYAV 1456
I W P G S I+ Y++E W +++ T + + L+ Y+FR A
Sbjct: 8101 ITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAE 8160
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY 1516
N IS+ S T K + I +P V ++ + ++I L G P P +TW
Sbjct: 8161 NAAGISEPSRATPPTKAV--DPIDAPKVIL-RTSLEVKRGDEIALDASISGSPYPTITWI 8217
Query: 1517 RD 1518
+D
Sbjct: 8218 KD 8219
Score = 61.7 bits (143), Expect = 3e-08
Identities = 82/345 (23%), Positives = 146/345 (42%), Gaps = 28/345 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F ++ + V S+ L C++ P+P + W +G+EI+ D + I+ Y
Sbjct: 24431 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIAD-GLKYRIQEFKGGYHQ 24489
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK-EPPQVIEPLKSMIVRQGESV 752
++ I +V Y V A N+ G S L+++ K P+ +E + ++ +GE V
Sbjct: 24490 LI-IASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVV 24548
Query: 753 ILSAQVVGNPRPTITWCK------NNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ G P P ITW K NN + + T+S S+ + KD G Y +
Sbjct: 24549 SIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRS---FTSLVFPNGVERKDAGFYVVC 24605
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLV-ARVTRNPVPSIT 865
A+N GI + TVE + +PP R +++ + ++ L + IT
Sbjct: 24606 AKNRFGIDQK----TVELDVADVPDPP----RGVKVSDASRDSVNLTWTEPASDGGSKIT 24657
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTI 923
Y + + +E + + N+ + S ++ +A N G K S + TI
Sbjct: 24658 NYIVEKCATTAERWLRVGQARETRYTVINLFGK-TSYQFRVIAENKFGLSKPSEPSEPTI 24716
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEIS 968
E T + + E +E + V + + SH+ STK + K I+
Sbjct: 24717 TKEDKT--RAMNYDEEVDETREVSM-TKASHS-STKELYEKYMIA 24757
Score = 60.9 bits (141), Expect = 5e-08
Identities = 60/235 (25%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++++ T G Q CQ+ G P P I W+R + S+ ++M D TL
Sbjct: 24035 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKM-SSDGRTHTL 24093
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
+ ED G +TC+A N G ++++L+++A H
Sbjct: 24094 TVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFH--------------------- 24132
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
P + K K Y GS + L + P P + W F G++++ + ++ IE+
Sbjct: 24133 -----PGYPLKEK-YYGAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQNSE-NITIENTE 24184
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPL 741
H V+K +K G Y V N G +A L + ++ K + P VIE L
Sbjct: 24185 HYTHLVMKNVQ-RKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEAL 24238
Score = 60.5 bits (140), Expect = 6e-08
Identities = 48/209 (22%), Positives = 84/209 (40%), Gaps = 10/209 (4%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ G P K+ K G L C++V P PDI W G+E++ ++ +
Sbjct: 24030 LTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGR 24089
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV- 746
H L + ++ EG YT +A N GE L ++ + P PLK
Sbjct: 24090 TH----TLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGY--PLKEKYYG 24143
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDE---GVY 803
G ++ L +G P P +TW K ++ + +T T L K V+ + G Y
Sbjct: 24144 AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKY 24203
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEP 832
++ N G + + +++ ++ P
Sbjct: 24204 KVQLSNVFGTVDAILDVEIQDKPDKPTGP 24232
Score = 60.1 bits (139), Expect = 9e-08
Identities = 61/251 (24%), Positives = 95/251 (37%), Gaps = 34/251 (13%)
Query: 480 YTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRP 539
Y + KK+ + D + + E+P P F L K G V+F + +P P
Sbjct: 25171 YCRRTMKKIKRRTDTMRLLERP--------PEFTLPLYNKTAYVGENVRFGVTITVHPEP 25222
Query: 540 QITWFRQTAIIKPSQDFQMY--YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTE 597
+TW++ IKP + + Y D + L I V +D +T VA+N G S +
Sbjct: 25223 HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 25282
Query: 598 LIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
L V L ++ T + P F + EG + E R+
Sbjct: 25283 LTV--TLHPPPTDST-------------------LRPMFKRLLANAECQEGQSVCFEIRV 25321
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
IP P + W G+ + NI + I + Y L I + G Y V A N G
Sbjct: 25322 SGIPPPTLKWEKDGQPLSLGPNIEI-IHEGLDYY--ALHIRDTLPEDTGYYRVTATNTAG 25378
Query: 718 EASLPIVLKIK 728
S L+++
Sbjct: 25379 STSCQAHLQVE 25389
Score = 60.1 bits (139), Expect = 9e-08
Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 20/166 (12%)
Query: 1047 VVWERDGEIIKPKKN--KYDFEKRGHIRKLYIRNTSVHDEGEYSCILR----DESCTAEV 1100
V W + G+ IKP N KY FE + +L I + + D+ EY+ + R ++SC A++
Sbjct: 25224 VTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKL 25283
Query: 1101 TVVELPPEIITRLQ--------NQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNH 1151
TV PP + L+ N + +G FEI ++ ++W KDG + +
Sbjct: 25284 TVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPN 25343
Query: 1152 IQLTIDG-KKQKLKIYDCDLDDAGEY----SCEVGNSKCTAILTVE 1192
I++ +G L I D +D G Y + G++ C A L VE
Sbjct: 25344 IEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 25389
Score = 58.8 bits (136), Expect = 2e-07
Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 16/157 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA-----SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
ITN+ + +E + VVAVN +G + ++PIV K E P V S V+ G+
Sbjct: 16693 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIE---PDVKPAFSSYSVQVGQD 16749
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV-KDE-GVYTLKAEN 809
+ + + G P+PTITW K+ P+K + D+ +T L K+ KD+ G Y + N
Sbjct: 16750 LKMEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVAN 16809
Query: 810 SEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVK 845
G S ++T+++P +PP +F +++ +
Sbjct: 16810 VVGQKTASIEIVTLDKP-----DPPKGPVKFDDVSAE 16841
Score = 58.8 bits (136), Expect = 2e-07
Identities = 65/275 (23%), Positives = 110/275 (40%), Gaps = 31/275 (11%)
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSY-RFRAYAVNEVDISDASETTEYY-- 1471
Y + Y+ D + VK+ITK K + Y +YA E+ + E +YY
Sbjct: 25118 YEITYE--DGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYA--ELFVKGVREVYDYYCR 25173
Query: 1472 KVIKETKIQSPTVEK---------PLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ +K+ K ++ T+ PL N T E++ P+P VTWY+ G+K+
Sbjct: 25174 RTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKI 25233
Query: 1523 KTA----KATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGE--VETSCVVGIQQKPVI 1573
K K T+E+ Y +A N +GE + V + P
Sbjct: 25234 KPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTD 25293
Query: 1574 TISNEDIKQ-----KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KT 1627
+ K+ + + G + GIPPP + W K+G L I +
Sbjct: 25294 STLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDY 25353
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ I++ + Y + A+NTAG++S + L+V
Sbjct: 25354 YALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 25388
Score = 58.8 bits (136), Expect = 2e-07
Identities = 36/128 (28%), Positives = 56/128 (43%), Gaps = 2/128 (1%)
Query: 476 DENNYTQYLQKKLNEKI--DKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQV 533
D+ YT + K E KL V P + ++ P+F L +G +V FE +V
Sbjct: 25262 DDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRV 25321
Query: 534 EGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFAS 593
G P P + W + + + ++ ++ + L IR+ PED G + A N AG S
Sbjct: 25322 SGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTS 25381
Query: 594 STTELIVE 601
L VE
Sbjct: 25382 CQAHLQVE 25389
Score = 58.4 bits (135), Expect = 3e-07
Identities = 66/331 (19%), Positives = 119/331 (35%), Gaps = 16/331 (4%)
Query: 736 QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK 795
Q +EP+ V + N + + + K + + D LKP
Sbjct: 4151 QKVEPITEPEVESKYLISTEEVSYFNVQSRVKYLDATPVTKGVASAVVSDEKQDESLKPS 4210
Query: 796 KVKDEGVYTLKAENSEGIAETSAVITVEEPTEE--NAEPPLFINRFQEITVKEKGTIKLV 853
+ K+E +SE E A + ++E + P+ + +E + L
Sbjct: 4211 EEKEES-------SSESGTEEVATVKIQEAEGGLIKEDGPMIHTPLVDTVSEEGDIVHLT 4263
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+T + WY N+++ E D LVI V++E G+Y C A N +G
Sbjct: 4264 TSITN--AKEVNWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSG 4321
Query: 914 KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSHTVSTKWYHNKKEISGMD 971
K++ A++T+ +K + E G C Q++ V +W+ +EI D
Sbjct: 4322 KTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESD 4381
Query: 972 HREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRKLQDFEVK 1029
I D G C ++ S + T+P +K++ +
Sbjct: 4382 KCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTVPGGEKKVRKLLPE 4441
Query: 1030 EKDVAILEVEINSETADVVWERDGEIIKPKK 1060
K EV + S E + + ++PKK
Sbjct: 4442 RKPEPKEEVVLKSVLRKRPEEEEPK-VEPKK 4471
Score = 58.4 bits (135), Expect = 3e-07
Identities = 45/148 (30%), Positives = 70/148 (47%), Gaps = 8/148 (5%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---PPQVIEPLKSMIVRQGES 751
L +T +K+ ++ + V A N G SLP + KE PP+++ P + + ++ G+
Sbjct: 12361 LVVTGLKEGKKYKFRVAARNAVG-VSLPREAEGVYEAKEQLLPPKILMP-EQITIKAGKK 12418
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKS--DGDTHSITILKPKKVKDEGVYTLKAEN 809
+ + A V G P PT W K V + D+ SI I+K KD G Y+L AEN
Sbjct: 12419 LRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAEN 12478
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFIN 837
S G +T + V +PP I+
Sbjct: 12479 SSG-TDTQKIKVVVMDAPGPPQPPFDIS 12505
Score = 57.6 bits (133), Expect = 5e-07
Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E+ + AP F+ K + +G +V F CQV G P+P + W + + +++
Sbjct: 1025 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKV 1084
Query: 559 YYD-DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
Y+ LVI F +DAG +T V +N G S++ L+ EA
Sbjct: 1085 SYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEA 1129
Score = 57.2 bits (132), Expect = 6e-07
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 7/197 (3%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------ATYENRX 1533
Q+PT +PL+++ G P P+V+W+RDG+ + T+ + + R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDEWLV 1592
Y A N G+ ++ + ++ + + ++ + G + +
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ GIP P V +Y++G ++++ ++ I+ + + I E S Y++ A+N+ G
Sbjct: 124 QVRVTGIPNPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 1653 TSSVEVTLKVYDKPSKP 1669
++ L V + P
Sbjct: 184 RATSTAELLVQGEEEVP 200
Score = 57.2 bits (132), Expect = 6e-07
Identities = 26/91 (28%), Positives = 48/91 (52%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++L+P G FE V G P P +TWF++ + S + + ++ + T +
Sbjct: 3575 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFI 3634
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ + ED+G + C A+N G ++ EL+V
Sbjct: 3635 VNDPQREDSGLYICKAENMLGESTCAAELLV 3665
Score = 57.2 bits (132), Expect = 6e-07
Identities = 42/167 (25%), Positives = 69/167 (41%), Gaps = 5/167 (2%)
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC-TEDDQCEYTCVLLD- 1272
+LT I + +V WY + ++ EKF + D TL+I K TED Q EY C L+
Sbjct: 4261 HLTTSITNAK-EVNWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALND 4319
Query: 1273 -AKSTTKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
K+ T K+ VV+ ++ + E + G + Q+ P +W + I +
Sbjct: 4320 SGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE 4379
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+SL I + + D G Y + N G +T+
Sbjct: 4380 SDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4426
Score = 56.8 bits (131), Expect = 8e-07
Identities = 44/153 (28%), Positives = 76/153 (49%), Gaps = 10/153 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA----SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ N+ + +E T+ V+AVN G + S P+++K +T E K +I + G+++
Sbjct: 14527 VRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNI 14586
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAENS 810
+ V+G P+PT+TW K ++ +K + T + TIL + D G Y L A N
Sbjct: 14587 KVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNI 14646
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G E VIT++ + PP +F E++
Sbjct: 14647 VG--EVGDVITIQ--VHDIPGPPTGPIKFDEVS 14675
Score = 56.4 bits (130), Expect = 1e-06
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 5/136 (3%)
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A+ + V P E PP ++ + +TV E ++ L ++ P P++TWYR + I
Sbjct: 878 AKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQI 937
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
S F L+I +E DSG + C A N AG S + + V + F K
Sbjct: 938 ESSIDFQITFQSGIARLMIREAFAE-DSGRFTCSAVNEAGTVSTSCYLAVQVSE-EFEKE 995
Query: 934 ---LQKSYETEEGKTV 946
+ + + TEE + V
Sbjct: 996 TTAVTEKFTTEEKRFV 1011
Score = 56.4 bits (130), Expect = 1e-06
Identities = 87/445 (19%), Positives = 153/445 (34%), Gaps = 33/445 (7%)
Query: 540 QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELI 599
++TW++ +K + FQ +Y D L I + D G + C G + + + +
Sbjct: 26251 EVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFM 26310
Query: 600 VEAPLSDHGSEMTVXXXXXXXXXXXXADILE----GIPPTFSKKP----KAQYVDEGSDI 651
+A S H + + + P S KP Q SD
Sbjct: 26311 GQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDS 26370
Query: 652 LLECRLVAI--PEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYT 709
+ + + A P P W G+ I + + D + L+I G YT
Sbjct: 26371 VAKFAVKATGEPRPTAIWTKDGKAIT--QGGKYKLSEDKGGF--FLEIHKTDTSDSGLYT 26426
Query: 710 VVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNP-RPTITW 768
N G S L IK + Q + K+ + + ++ ++ R
Sbjct: 26427 CTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIK 26486
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL-KAENSEGIAETSAVITVEEPTE 827
K + L K + +L ++VK +L K+ E I +TS E
Sbjct: 26487 MSEAKSQEKLALKEEAS----KVLISEEVKKSAATSLEKSIVHEEITKTS---QASEEVR 26539
Query: 828 ENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGEN 887
+AE F ++++ E + L A + + W N ++ SE G +
Sbjct: 26540 THAEIKAFST---QMSINEGQRLVLKANIA--GATDVKWVLNGVELTNSEEYRYGVSGSD 26594
Query: 888 IELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
L I S D G C++ G K + ++ ++ +S EG+
Sbjct: 26595 QTLTIKQA-SHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQN 26653
Query: 946 VILECQTSHTVS--TKWYHNKKEIS 968
V+ C+ S S +W+ N IS
Sbjct: 26654 VLFTCEISGEPSPEIEWFKNNLPIS 26678
Score = 56.0 bits (129), Expect = 1e-06
Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 1/108 (0%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMY 559
P S+ AP F E+LR + S C+V G+P+P + W+RQ II +++
Sbjct: 24422 PKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQ 24481
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDH 607
L+I V +DA + A N G S T L VE P H
Sbjct: 24482 EFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIH 24529
Score = 56.0 bits (129), Expect = 1e-06
Identities = 70/320 (21%), Positives = 130/320 (40%), Gaps = 32/320 (10%)
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYE-------REYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
L + T++ K EV+ P +D+ R +R+ G + +++ Q+ P +W
Sbjct: 25853 LKTQKTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYH 25912
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD--VEMNVTILDKP 1381
N +++ + S +L I D+G Y+ N G A ++VT D
Sbjct: 25913 NGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYT 25972
Query: 1382 SPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS----VKN-ITKT 1436
+ + E+ S PE T T Y V +++ E S VK+ +T+T
Sbjct: 25973 TYASQRRDEEVPRSVF------PELT--RTEAYAVPSFKKTSEMEASSSVREVKSQMTET 26024
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
+ S+ + + ++S ++ A+ E + + S T + +T + + + KP +++T
Sbjct: 26025 RESLSSYEHSASAEMKSAALEEKSLEEKSTTRKI-----KTTLAARILTKP-RSMTVYEG 26078
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIA 1552
E +C G P P VTW R G+ L T+ T + + Y +
Sbjct: 26079 ESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVV 26138
Query: 1553 FNDHGEVETSCVVGIQQKPV 1572
N G+ E + IQ+ V
Sbjct: 26139 ENSEGKQEAEFTLTIQKARV 26158
Score = 55.6 bits (128), Expect = 2e-06
Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENR 1532
E + PT+ LKN+T E + L C G P P VTWYR+ +++++ + T+++
Sbjct: 891 EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG 950
Query: 1533 -XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+ C A N+ G V TSC + +Q
Sbjct: 951 IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 987
Score = 53.6 bits (123), Expect = 7e-06
Identities = 27/100 (27%), Positives = 48/100 (48%), Gaps = 2/100 (2%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
T +++ P V P +G T +F C+V GYP+P++ W+ +I+ S+ F++ Y
Sbjct: 1787 TDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY- 1845
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
D + L I + D G A+N G +L ++
Sbjct: 1846 -DGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1884
Score = 53.6 bits (123), Expect = 7e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 12/151 (7%)
Query: 686 SDMHMYCSVLKITNVK-----KFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---PPQV 737
SD C+ +K+T + +E ++ V A N +G S P L + K+ PP
Sbjct: 15595 SDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKG-ISDPRQLSVPVIAKDLVIPPAF 15653
Query: 738 IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV 797
+ V GE + + +G P P +TW K+N P+K + T + ++L K
Sbjct: 15654 KLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDA 15713
Query: 798 --KDEGVYTLKAENSEGIA-ETSAVITVEEP 825
+D G Y +K NS G A ET VI +++P
Sbjct: 15714 CREDVGHYVVKLTNSAGEAIETLNVIVLDKP 15744
Score = 52.8 bits (121), Expect = 1e-05
Identities = 35/169 (20%), Positives = 68/169 (40%), Gaps = 4/169 (2%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
AEN G++ + + E P +++T K +L ++ P+P I W
Sbjct: 24010 AENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKW 24069
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
YR + + S + DG L + + E D G Y C+A+N G+ +++ +
Sbjct: 24070 YRFGKELIQSRKYKMSSDGRTHTLTVMTEEQE-DEGVYTCIATNEVGEVETSSKLLLQAT 24128
Query: 927 KVTFVKH-LQKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDH 972
+ L++ Y G T+ L + W+H +K + ++
Sbjct: 24129 PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSEN 24177
Score = 52.0 bits (119), Expect = 2e-05
Identities = 36/131 (27%), Positives = 66/131 (50%), Gaps = 5/131 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLP-IVLKIKTGEK-EPP--QVIEPLKSMI-VRQGES 751
+ ++K Q+ ++ V AVN +G + + +I+ E+ E P ++ + LK + +R G S
Sbjct: 22907 VPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGAS 22966
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L V G P P ITW K + + +++S+ I+ D G YT++AEN
Sbjct: 22967 LRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQS 23026
Query: 812 GIAETSAVITV 822
G + ++ V
Sbjct: 23027 GKKSATVLVKV 23037
Score = 51.6 bits (118), Expect = 3e-05
Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 5/116 (4%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT--I 791
PP ++ LK++ V +GESV L + G P PT+TW + + +++ I +
Sbjct: 896 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 955
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
++ +D G +T A N G TS + V+ E E +F T +EK
Sbjct: 956 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKF---TTEEK 1008
Score = 51.6 bits (118), Expect = 3e-05
Identities = 35/117 (29%), Positives = 59/117 (50%), Gaps = 10/117 (8%)
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKSMI-VRQGESVILSAQV 758
+F+ T V ++ E S P+ + E PP++ +KS++ V+ G +V L A V
Sbjct: 12766 QFRAIARTAVNISPPSEPSDPVTI---LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATV 12822
Query: 759 VGNPRPTITWCKNN---KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
G P PT++W K+ KP + + + ++ + + KD G YT+ AENS G
Sbjct: 12823 FGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNR-KDSGDYTITAENSSG 12878
Score = 51.2 bits (117), Expect = 4e-05
Identities = 38/149 (25%), Positives = 69/149 (46%), Gaps = 8/149 (5%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLK--IKTGEKEPPQVIE--P--LKSMIVRQGE 750
+T + + ++A N G S P I T ++ P ++E P +I++ GE
Sbjct: 21418 VTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGE 21477
Query: 751 SVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSITILKPKKVKD-EGVYTLKAE 808
S+ + A V G P P +TW K+ + K + + S ++ +D GVYT++A+
Sbjct: 21478 SLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITNVLGSTSLFVRDATRDHRGVYTVEAK 21537
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFIN 837
N+ G A+ + V++ + P F N
Sbjct: 21538 NASGSAKAEIKVKVQDTPGKVVGPIRFTN 21566
Score = 51.2 bits (117), Expect = 4e-05
Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 4/120 (3%)
Query: 486 KKLNEKIDKLPVFEK--PTSEEQ-SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQIT 542
KK ++K + V K P + E S P+ V L+ S +F + G PRP
Sbjct: 26328 KKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI 26387
Query: 543 WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
W + I +++ +D L I + D+G +TC KN+AG SS+ +L ++A
Sbjct: 26388 WTKDGKAITQGGKYKL-SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKA 26446
Score = 50.8 bits (116), Expect = 5e-05
Identities = 40/140 (28%), Positives = 71/140 (50%), Gaps = 14/140 (10%)
Query: 696 KITNVKKFQEGTYTVVAVNREGE---ASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQG 749
K+T ++ Q + V+AVN GE A +P + +K EPP++I + ++ G
Sbjct: 10678 KVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKD-RLEPPELILDANMAREQHIKVG 10736
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI---TILKPKKVKDEGVYTLK 806
+++ LSA + G P P +TW K ++ PTK+ D + ++ +D G+Y+L
Sbjct: 10737 DTLRLSAIIKGVPFPKVTWKKEDRDA---PTKARIDVTPVGSKLEIRNAAHEDGGIYSLT 10793
Query: 807 AENSEGIAETSA-VITVEEP 825
EN G S V+ +++P
Sbjct: 10794 VENPAGSKTVSVKVLVLDKP 10813
Score = 50.4 bits (115), Expect = 7e-05
Identities = 51/230 (22%), Positives = 89/230 (38%), Gaps = 12/230 (5%)
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE----PPQVIEPLKSMIVRQ 748
+V + N+ + E + V N GE+ + + T + + P E L+++ VR
Sbjct: 24385 TVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRY 24444
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTK-----SDGDTHSITILKPKKVKDEGVY 803
+ L +V G+P+P + W + K + A K G H + I+ D VY
Sbjct: 24445 QSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL-IIASVTDDDATVY 24503
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
++A N G +A + VE P + + P + + + + + P P
Sbjct: 24504 QVRATNQGGSVSGTASLEVEVPAKIHL--PKTLEGMGAVHALRGEVVSIKIPFSGKPDPV 24561
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
ITW + ++I + LV N D+G Y A N G
Sbjct: 24562 ITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 24611
Score = 50.0 bits (114), Expect = 9e-05
Identities = 54/226 (23%), Positives = 96/226 (42%), Gaps = 22/226 (9%)
Query: 705 EGTYTVVAVNREGEA--SLP---IVLKIKTGEKEPPQVIEPLKSMIV-------RQGESV 752
E ++ + A+N+ G + S P + ++ P+VI+ KS + G S
Sbjct: 12664 EYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSK 12723
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
I+ V P W + N +P + ++ T L+ K A N
Sbjct: 12724 IIGYFVEACKLPGDKWVRCNTAPHQIPQEE----YTATGLEEKAQYQFRAIARTAVNISP 12779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQE--ITVKEKGTIKLVARVTRNPVPSITWYRNN 870
+E S +T+ EN P + ++ + +TVK + L A V P+P+++W ++
Sbjct: 12780 PSEPSDPVTI---LAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDG 12836
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
++ P+E I L + +V+ + DSGDY A NS+G S
Sbjct: 12837 TLLKPAEGIKMAMQRNLCTLELFSVNRK-DSGDYTITAENSSGSKS 12881
Score = 49.6 bits (113), Expect = 1e-04
Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 3/118 (2%)
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+ E E +A A+ V +E +P + + + + V E T + RVT P P +
Sbjct: 1769 RIEELERMAHEGALTGVTTDQKEKQKPDIVLYP-EPVRVLEGETARFRCRVTGYPQPKVN 1827
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
WY N ++I S+ +DG + L I + S D+G+ K A N G H ++ I
Sbjct: 1828 WYLNGQLIRKSKRFRVRYDGIHY-LDIVDCKS-YDTGEVKVTAENPEGVIEHKVKLEI 1883
Score = 49.6 bits (113), Expect = 1e-04
Identities = 44/129 (34%), Positives = 62/129 (48%), Gaps = 13/129 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-----VRQGES 751
+ N+ + Q + V AVN GE+ + L + + E P I+ S+ V+ GE
Sbjct: 8859 VENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEP 8918
Query: 752 VILSAQVVGNPRPTITWCKN----NKPVKALP-TKSD-GDTHSITILK-PKKVK-DEGVY 803
V + A V G P P I W KN KP AL TK + + + T L PK V+ D+G Y
Sbjct: 8919 VHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTY 8978
Query: 804 TLKAENSEG 812
T+ A N G
Sbjct: 8979 TVTASNRLG 8987
Score = 49.2 bits (112), Expect = 2e-04
Identities = 72/330 (21%), Positives = 128/330 (38%), Gaps = 42/330 (12%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E + F + K + EG + C++ P P IAW G+ I E + D
Sbjct: 1241 EAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGR 1300
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+ L+I V EG YT A N +G A I +G+ +EP +
Sbjct: 1301 ---ASLRIPVVLPEDEGIYTAFASNIKGNA-------ICSGKL----YVEPAAPL---GA 1343
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ I + + V R + P++ P + + P ++ + +
Sbjct: 1344 PTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR----------MSPARMSPARMSPARMSP 1393
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ ET +E E P+F+ + E + +V P+P W+ +
Sbjct: 1394 GRRLEET------DESQLERLYKPVFVLKPVSFKCLEGANCRFDLKVVGRPMPETFWFHD 1447
Query: 870 NEIISPSET--ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID-VE 926
+ I T + DG +++ S DSG++ VA N AG+SS +T++ VE
Sbjct: 1448 GQQIVNDYTHKVVIKEDGTQSLIIVPATPS--DSGEWTVVAQNRAGRSSISVILTVEAVE 1505
Query: 927 ---KVTFVKHLQKSYETEEGKTVILECQTS 953
K FV+ L K+ +EG + ++ + +
Sbjct: 1506 HQVKPMFVEKL-KNVNIKEGSRLEMKVRAT 1534
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/127 (26%), Positives = 55/127 (43%), Gaps = 3/127 (2%)
Query: 477 ENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGY 536
E++ +Y+ + LN+ K K T +++ AP+ K+ P G +F C+++
Sbjct: 4306 EDHQGEYVCEALNDS-GKTATSAKLTVVKRA-APVIKRKIEPLEVALGHLAKFTCEIQSA 4363
Query: 537 PRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTT 596
P + WF+ I S D +++L I D G +TC A N G S T
Sbjct: 4364 PNVRFQWFKAGREIYES-DKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTA 4422
Query: 597 ELIVEAP 603
L V P
Sbjct: 4423 TLTVTVP 4429
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPP---LFINRFQEITVKEKGTIKLVARVTRN 859
+ +KAEN G+ I +E +E PP L + + + VK T++ A +
Sbjct: 10983 FRVKAENIVGLGLPDTTIPIE--CQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGV 11040
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
PVP+ W + I E T D + L I N D+G+Y+ SN+AG +
Sbjct: 11041 PVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRR-DTGEYQITVSNAAGSKTVAV 11099
Query: 920 RVTI 923
+T+
Sbjct: 11100 HLTV 11103
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/130 (26%), Positives = 66/130 (50%), Gaps = 11/130 (8%)
Query: 691 YCSVLKITNVKKFQEGTYTVVA---VNREGEASLPIVLKIKTGEKEPPQVIEPLKS---M 744
Y V ++T ++++ + A V+ E++ PI++K + EPP+V+ +K +
Sbjct: 19246 YFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVK---DDVEPPRVMMDVKFRDVI 19302
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPV--KALPTKSDGDTHSITILKPKKVKDEGV 802
+V+ GE + ++A + G P P I+W K+ + +A D H++ +K +D G
Sbjct: 19303 VVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQ 19362
Query: 803 YTLKAENSEG 812
Y L +N G
Sbjct: 19363 YVLTLKNVAG 19372
Score = 48.8 bits (111), Expect = 2e-04
Identities = 42/198 (21%), Positives = 80/198 (40%), Gaps = 14/198 (7%)
Query: 1472 KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY-- 1529
K+ +++P + + +++ T D G P P+ WY++G K++ + Y
Sbjct: 2022 KIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWY 2081
Query: 1530 ---ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE--DIKQKH 1584
+N A N GE + + +Q K +IT + E D+ K
Sbjct: 2082 WPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKE 2141
Query: 1585 KVGDEWLVTAVIEGIPP-PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY 1643
K + + T E P +V WYK+G ++ +Y + + K + I + S + Y
Sbjct: 2142 K---DTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDY 2198
Query: 1644 T---IEASNTAGTSSVEV 1658
+ +E N T+ + V
Sbjct: 2199 SCVLVEDENVKTTAKLIV 2216
Score = 48.0 bits (109), Expect = 4e-04
Identities = 76/333 (22%), Positives = 128/333 (38%), Gaps = 34/333 (10%)
Query: 1090 ILRDESCTAEVTVVELP--PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEI 1146
++ D S T E P P IT+ QK+ +G F ++ V W K G +
Sbjct: 1017 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1076
Query: 1147 QFSNHIQLTIDGK--KQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTL 1200
+++ + + + KL I DDAGEY+ V G + +A L +EE +
Sbjct: 1077 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL-LEEADYELLM 1135
Query: 1201 RLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
+ + +L A++ ET Y + + E+ + + K T+++R E
Sbjct: 1136 KSQQEMLYQTQVTAFVQEPEVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE 1195
Query: 1261 DDQ-------------CEYTCV------LLDAKSTTKLKVEVVEFPPKIVDYE---REYR 1298
D + EY + LL+ K+ V++ E ++ + YR
Sbjct: 1196 DQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDLRIKNYR 1255
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC-KHTKPSIDSKSASLTIKKVENTDAGI 1357
I G VT +P P W + K IK ++ + ASL I V D GI
Sbjct: 1256 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1315
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
Y N G+A + ++ +P G P +
Sbjct: 1316 YTAFASNIKGNA-ICSGKLYVEPAAPLGAPTYI 1347
Score = 48.0 bits (109), Expect = 4e-04
Identities = 53/236 (22%), Positives = 100/236 (42%), Gaps = 15/236 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+TN+ E + V AVN G + P++ E +PP+ +E + M
Sbjct: 12262 VTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEATE-MTKNSATL 12320
Query: 752 VILSAQVVGNPRPT---ITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
L G + I++ + +P S S+ + K+ K + + + A
Sbjct: 12321 AWLPPLRDGGAKIDGYIISYREEEQPADRWTEYSVVKDLSLVVTGLKEGK-KYKFRVAAR 12379
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
N+ G++ V E E+ P + + ++IT+K +++ A V P P+ W +
Sbjct: 12380 NAVGVSLPREAEGVYEAKEQLLPPKILMP--EQITIKAGKKLRIEAHVYGKPHPTCKWKK 12437
Query: 869 -NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+E+++ S D +I L+I +V + DSG Y A NS+G + +V +
Sbjct: 12438 GEDEVVTSSHLAVHKADSSSI-LIIKDVTRK-DSGYYSLTAENSSGTDTQKIKVVV 12491
Score = 48.0 bits (109), Expect = 4e-04
Identities = 24/77 (31%), Positives = 44/77 (57%), Gaps = 1/77 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+ V + V G P P ++W + ++KP++ +M N+ TL + V +D+G +T
Sbjct: 12813 GTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQR-NLCTLELFSVNRKDSGDYTI 12871
Query: 584 VAKNAAGFASSTTELIV 600
A+N++G S+T +L V
Sbjct: 12872 TAENSSGSKSATIKLKV 12888
Score = 47.6 bits (108), Expect = 5e-04
Identities = 41/190 (21%), Positives = 72/190 (37%), Gaps = 7/190 (3%)
Query: 1478 KIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXX 1534
K P + PL + +E + + LT + V WY + K + + K +
Sbjct: 4239 KEDGPMIHTPLVDTVSEEGDIVHLTTSITNAKE--VNWYFENKLVPSDEKFKCLQDQNTY 4296
Query: 1535 XXXXXXXXXXXXX--YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLV 1592
Y C A ND G+ TS + + ++ I + + +G
Sbjct: 4297 TLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKF 4356
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
T I+ P W+K G ++ + +I + + S + I + +YT +ASN G
Sbjct: 4357 TCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYG 4416
Query: 1653 TSSVEVTLKV 1662
+ S TL V
Sbjct: 4417 SVSCTATLTV 4426
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/68 (35%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P PE W+ +G ++ ND + + KE T + I S S ++T+ A N AG S
Sbjct: 1434 VVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRS 1493
Query: 1655 SVEVTLKV 1662
S+ V L V
Sbjct: 1494 SISVILTV 1501
Score = 47.2 bits (107), Expect = 6e-04
Identities = 47/207 (22%), Positives = 87/207 (42%), Gaps = 17/207 (8%)
Query: 697 ITNVKKFQEGTYTVVAVNREGE---ASLPIVLKIKTGEKEPPQVIEPL--KSMIVRQGES 751
+T++ + E + V+A N G A +P +K+ + P ++ + + VRQG
Sbjct: 23597 LTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGV 23656
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L+ + G P P W K + + + +TH+ ++K D G Y L EN
Sbjct: 23657 IRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKC 23716
Query: 812 GIAETSAVITVEEPTEENA-EPPLFINRFQEITVK-------EKGTIKLVARV-TRNPVP 862
G + + I V N+ E PL + Q +V+ + G ++ + R VP
Sbjct: 23717 G--KKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVP 23774
Query: 863 SITWYRNNEIISPSETITQNFDGENIE 889
WY + + + + + EN+E
Sbjct: 23775 KAAWYTIDSRVRGTSLVVKGLK-ENVE 23800
Score = 46.8 bits (106), Expect = 9e-04
Identities = 39/124 (31%), Positives = 57/124 (45%), Gaps = 6/124 (4%)
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQGESVILSAQVVG 760
+E V AVN G S P + K+P P + +IV +GE + +
Sbjct: 7857 KEYVLRVRAVNAIG-VSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRA 7915
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVK-DEGVYTLKAENSEGIAETSA 818
P PT++W K+ K VKA + + H S + PK V+ D G+YT+ EN G A S
Sbjct: 7916 VPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASI 7975
Query: 819 VITV 822
+ V
Sbjct: 7976 NVKV 7979
Score = 46.4 bits (105), Expect = 0.001
Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 9/158 (5%)
Query: 1229 WYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK----LKVEV 1283
W+ + ++ D +I + ++LII T D E+T V + + L VE
Sbjct: 1444 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA 1503
Query: 1284 VEFP--PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
VE P V+ + IK GS + + V P P+ W+ NS II K+ K I+
Sbjct: 1504 VEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGT 1563
Query: 1342 --SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
A+L I + D+ Y N G V +
Sbjct: 1564 KGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1601
Score = 46.4 bits (105), Expect = 0.001
Identities = 39/149 (26%), Positives = 67/149 (44%), Gaps = 4/149 (2%)
Query: 803 YTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
+ +KA N EG A + + E L + ITV+ TI+++ARV P
Sbjct: 11380 FRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRP 11439
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
P ITW + +++ + + D +EL I D G Y A NS+G + A
Sbjct: 11440 EPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEA-VRADHGKYIISAKNSSGHAQGSAI 11498
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILE 949
V + +++ ++L+ + T+E T+ E
Sbjct: 11499 VNV-LDRPGPCQNLKVTNVTKENCTISWE 11526
Score = 46.4 bits (105), Expect = 0.001
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 5/116 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFI--NRFQEITVKEKGTIKLVARVTRNP 860
+ + A N +G++E S I EP E P L + + + +T++ +++L+ V+ P
Sbjct: 22918 FRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRP 22977
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P ITW + ++ I E+ L+I + + D+G Y A N +GK S
Sbjct: 22978 PPVITWSKQGIDLASRAIIDTT---ESYSLLIVDKVNRYDAGKYTIEAENQSGKKS 23030
Score = 46.0 bits (104), Expect = 0.001
Identities = 53/243 (21%), Positives = 84/243 (34%), Gaps = 21/243 (8%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQ--ITWFRQTAIIKPSQDFQMYYD 561
+E+ P F +KL FEC++ P + W ++ + +M +
Sbjct: 1651 KEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPISDPTMVVEWLHDGKPLEAANRLRMI-N 1709
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV--EAPLSDHGS---------- 609
+ +L + D+G TC A N G ++ LIV E L +
Sbjct: 1710 EFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQR 1769
Query: 610 -EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWL 668
E D E P P+ V EG CR+ P+P + W
Sbjct: 1770 IEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWY 1829
Query: 669 FKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
G+ I + V + +H L I + K + G V A N EG + L+I+
Sbjct: 1830 LNGQLIRKSKRFRVRYDG-IH----YLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1884
Query: 729 TGE 731
E
Sbjct: 1885 QRE 1887
Score = 46.0 bits (104), Expect = 0.001
Identities = 28/121 (23%), Positives = 52/121 (42%)
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
KF+ + + GE + I +K + + ++V G + + A V G
Sbjct: 9995 KFRVSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGK 10054
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
P PT+TW N + + T S ++K + +GVY+L A+N G + + ++
Sbjct: 10055 PPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVD 10114
Query: 822 V 822
V
Sbjct: 10115 V 10115
Score = 46.0 bits (104), Expect = 0.001
Identities = 27/79 (34%), Positives = 42/79 (53%), Gaps = 2/79 (2%)
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKP-VKALPTKSDGDTHSITILKPKKVK-DEGVY 803
VR G+++ + A+V G P P ITW K K V+ D + + + V+ D G Y
Sbjct: 11423 VRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKY 11482
Query: 804 TLKAENSEGIAETSAVITV 822
+ A+NS G A+ SA++ V
Sbjct: 11483 IISAKNSSGHAQGSAIVNV 11501
Score = 45.6 bits (103), Expect = 0.002
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G+ + I G P P V WY+ ++E+ ++ IT + + + I+E S ++T
Sbjct: 911 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 970
Query: 1647 ASNTAGTSSVEVTLKV 1662
A N AGT S L V
Sbjct: 971 AVNEAGTVSTSCYLAV 986
Score = 45.6 bits (103), Expect = 0.002
Identities = 40/182 (21%), Positives = 76/182 (41%), Gaps = 6/182 (3%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTH 787
EK+ P ++ + + V +GE+ +V G P+P + W N + + K + DG H
Sbjct: 1791 EKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IH 1849
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
+ I+ K D G + AEN EG+ E + +++ + + E V E
Sbjct: 1850 YLDIVDCKSY-DTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEP 1908
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCV 907
G ++ + PV + T + + +E IT E E + + + G Y+ +
Sbjct: 1909 GKLQFEVQKVDRPVDT-TETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 1967
Query: 908 AS 909
+
Sbjct: 1968 TA 1969
Score = 45.2 bits (102), Expect = 0.003
Identities = 41/179 (22%), Positives = 80/179 (44%), Gaps = 14/179 (7%)
Query: 747 RQGESVILSAQVVGNPRPTITWCK-NNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+ G S I+ V P T W + N++P+K L K + + P K E V +
Sbjct: 7813 KNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEG------VVPDK---EYVLRV 7863
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVK-EKGTIKLVARVTRNPVPSI 864
+A N+ G++E S + + + +P + + I ++ EK +I + R PVP++
Sbjct: 7864 RAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAV--PVPTV 7921
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+W+++ + + S+ +T D + L + D+G Y N G ++ V +
Sbjct: 7922 SWHKDGKEVKASDRLTMKNDHISAHLEVPK-SVRADAGIYTITLENKLGSATASINVKV 7979
Score = 45.2 bits (102), Expect = 0.003
Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G+++ L+ + P P ++W G + P E I +A++ ++ C+ L++ +V +
Sbjct: 12810 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL---CT-LELFSVNRKD 12865
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV 737
G YT+ A N G S I LK+ P V
Sbjct: 12866 SGDYTITAENSSGSKSATIKLKVLDKPGPPASV 12898
Score = 45.2 bits (102), Expect = 0.003
Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 9/99 (9%)
Query: 731 EKEPPQV-IEPL--KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDG 784
E +PP++ ++P +++V GES + A + G P PTI W K ++ + L KS
Sbjct: 16040 EVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTD 16099
Query: 785 DTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
S+++ +V D G Y LKA+N G E S + V+
Sbjct: 16100 FATSLSVKDAVRV-DSGNYILKAKNVAG--ERSVTVNVK 16135
Score = 45.2 bits (102), Expect = 0.003
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 1/81 (1%)
Query: 520 HTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAG 579
H P G V+ + G P P +WF + ++ S+ + VA L IRE D G
Sbjct: 23252 HVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVE-THTKVAKLTIRETTIRDTG 23310
Query: 580 TFTCVAKNAAGFASSTTELIV 600
+T KN G S T ++I+
Sbjct: 23311 EYTLELKNVTGTTSETIKVII 23331
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/125 (24%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
+E + + A+N +GI++ ++V ++ PP F F TV +K+
Sbjct: 15618 EEYSFRVSAQNEKGISDPRQ-LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIG 15676
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P++TW+++N + + + N L I + E D G Y +NSAG++
Sbjct: 15677 RPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACRE-DVGHYVVKLTNSAGEAIET 15735
Query: 919 ARVTI 923
V +
Sbjct: 15736 LNVIV 15740
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 13/136 (9%)
Query: 697 ITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIE---PLKSMIVRQ 748
++ +++ E + V A N+ G E LP+++K + EPP++ P ++ VR
Sbjct: 19937 VSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIK---EQLEPPEIDMKNFPSHTVYVRA 19993
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKA-LPTKSDGDTHSITI-LKPKKVKDEGVYTLK 806
G ++ + + G P P +T ++ P+KA + ++ ++TI LK D G Y +
Sbjct: 19994 GSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEIT 20053
Query: 807 AENSEGIAETSAVITV 822
A NS G + I V
Sbjct: 20054 AANSSGTTKAFINIVV 20069
Score = 44.8 bits (101), Expect = 0.003
Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 9/131 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK---EPPQV---IEPLKSMIVRQGE 750
++N+K + V AVN G+ PI + K E P++ + S+I + GE
Sbjct: 20732 VSNLKPGVNYYFRVSAVNCAGQGE-PIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGE 20790
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAE 808
V + G P PT+TW K+ K + + S +T S ++L +V D G Y L E
Sbjct: 20791 DVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIE 20850
Query: 809 NSEGIAETSAV 819
N G ++S V
Sbjct: 20851 NGVGEPKSSTV 20861
Score = 44.4 bits (100), Expect = 0.005
Identities = 100/457 (21%), Positives = 161/457 (35%), Gaps = 39/457 (8%)
Query: 1139 WFKDGSEI--QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVE 1192
WF DG +I +++ + + DG Q L I D+GE++ G S + ILTVE
Sbjct: 1444 WFHDGQQIVNDYTHKVVIKEDGT-QSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVE 1502
Query: 1193 --EPSIN--FTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE--KFTLIS 1246
E + F +L + + + D+ W K +I + K +
Sbjct: 1503 AVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEG 1562
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEV-VEFPP-----KIVDYEREYR 1298
+ L I D YT ++ + TT+ KV V VEF K++ YR
Sbjct: 1563 TKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYR 1622
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
K + L + + Q ++W + K K KP K SL +K+ +
Sbjct: 1623 AKEIAAPELEPLHLRYGQ--EQW-EEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAH---F 1676
Query: 1359 KLRLENNCGHADVEMNVTILDKPSPPGKPNILEI--DSSSINICWDEPENTGNSTIIYYV 1416
+ RL +D M V L P N L + + ++ + + + I
Sbjct: 1677 ECRLTPI---SDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRA 1733
Query: 1417 VEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
D T S I K + S+ R + E++ A E +
Sbjct: 1734 TNKYGTDHT---SATLIVKDEKSLVEESQLPEGRKGLQRIEELERM-AHEGALTGVTTDQ 1789
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG---KKLKTAKATYENRX 1533
+ Q P + + + E C G PQPKV WY +G +K K + Y+
Sbjct: 1790 KEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIH 1849
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
K A N G +E + IQQ+
Sbjct: 1850 YLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQR 1886
Score = 44.4 bits (100), Expect = 0.005
Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F + L + +G+T EC+V ++ WF+ I S+ +++ D V LVI
Sbjct: 5790 FTKPLEDQTVEEGATAVLECEVSR-ENAKVKWFKNGTEILKSKKYEIVADG-RVRKLVIH 5847
Query: 572 EVFPEDAGTFTCVAKN 587
+ PED T+TC AK+
Sbjct: 5848 DCTPEDIKTYTCDAKD 5863
Score = 44.4 bits (100), Expect = 0.005
Identities = 32/114 (28%), Positives = 48/114 (42%), Gaps = 5/114 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRF--QEITVKEKGTIKLVARVTRNP 860
+ + A N GI E V V E + P L ++ I V G I+++A V+ P
Sbjct: 9996 FRVSAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKP 10055
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
P++TW N + TI + +VI N G Y +A N AG+
Sbjct: 10056 PPTVTWNMNERTLPQEATIETT--AISSSMVIKNCQRS-HQGVYSLLAKNEAGE 10106
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/90 (25%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTI 1156
A V + PP +++ L+N V +G T E ++ + V W+++ +I+ S Q+T
Sbjct: 888 APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 947
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCT 1186
+L I + +D+G ++C N T
Sbjct: 948 QSGIARLMIREAFAEDSGRFTCSAVNEAGT 977
Score = 44.0 bits (99), Expect = 0.006
Identities = 38/133 (28%), Positives = 61/133 (45%), Gaps = 7/133 (5%)
Query: 795 KKVKDEGVYTLK--AENS--EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
K++++ Y L+ A N+ EG + +TV EP E A L ++ I + T+
Sbjct: 8567 KEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVE-LDVSVKGGIQIMAGKTL 8625
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
++ A VT PVP+ W + + + N G EL+I + + D G Y A+N
Sbjct: 8626 RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNV-GTKSELIIKDALRK-DHGRYVITATN 8683
Query: 911 SAGKSSHGARVTI 923
S G ARV +
Sbjct: 8684 SCGSKFAAARVEV 8696
Score = 44.0 bits (99), Expect = 0.006
Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 14/153 (9%)
Query: 700 VKKFQEGT---YTVVAVNREGEASLPIVLKIKTGEKE--PPQV-IEPLKSMIVRQGESVI 753
VK +EG Y V AVN G+ K T + E PP + ++ + +R GE+
Sbjct: 10281 VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFA 10340
Query: 754 LSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
L+ + G P+P ++W K+ V K+ T ++ +K K+ D G Y + ENS
Sbjct: 10341 LTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKR-SDSGKYCVVVENS 10399
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G + + V ++ PP+ F E+T
Sbjct: 10400 TGSRKGFCQVNV----VDHPGPPVGPVSFDEVT 10428
Score = 44.0 bits (99), Expect = 0.006
Identities = 38/148 (25%), Positives = 62/148 (41%), Gaps = 10/148 (6%)
Query: 779 PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPP---LF 835
PT G ++T LK E + + A NSEG+ E A + +E EPP L
Sbjct: 18558 PTGLQGKQFTVTKLKENT---EYNFRICAINSEGVGEP-ATLPGSVVAQERIEPPEIELD 18613
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV 895
+ + + ++ T++L + P P + W + I++ I LVI NV
Sbjct: 18614 ADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQI--EVTSSFTMLVIDNV 18671
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ DSG Y N++G + V +
Sbjct: 18672 -TRFDSGRYNLTLENNSGSKTAFVNVRV 18698
Score = 43.6 bits (98), Expect = 0.008
Identities = 44/191 (23%), Positives = 80/191 (41%), Gaps = 12/191 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PP+ K + V+EG+++ + ++ +P P + W FK PD V ++ ++
Sbjct: 9619 MPPSIDLKEFME-VEEGTNVNIVAKIKGVPFPTLTW-FKAPPKKPDNKEPVLYDTHVNKL 9676
Query: 692 C----SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
L I ++ G YT+ AVN G AS + L + G PP + P+K V
Sbjct: 9677 VVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV-LGRPGPP--VGPIKFESVS 9733
Query: 748 QGESVI--LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK-DEGVYT 804
+ + + G + T + + + + T PK ++ E V+
Sbjct: 9734 ADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFR 9793
Query: 805 LKAENSEGIAE 815
+ A+N GI E
Sbjct: 9794 IMAQNKYGIGE 9804
Score = 43.2 bits (97), Expect = 0.010
Identities = 40/134 (29%), Positives = 66/134 (49%), Gaps = 12/134 (8%)
Query: 475 MDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSM----AP-IFVE-KLRPKHTPD-GSTV 527
++E + Y K LN + P +PT E Q++ AP IF++ KL T G+ +
Sbjct: 7154 LEEGKWYAYRVKTLNRQGASKP--SRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKI 7211
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATLVIREVFPEDAGTFTCVAK 586
+ V G P P+ITW + I+K QD ++ ++ +T+ I + D GT+ A
Sbjct: 7212 ELPATVTGKPEPKITWTKADMILK--QDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAV 7269
Query: 587 NAAGFASSTTELIV 600
N G A++ E+ V
Sbjct: 7270 NVCGRATAVVEVNV 7283
Score = 43.2 bits (97), Expect = 0.010
Identities = 30/119 (25%), Positives = 58/119 (48%), Gaps = 7/119 (5%)
Query: 709 TVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL--KSMIVRQGESVILSA-QVVGNPRPT 765
T A++ E++ I+ K + + P V++P + ++ G++++L+A ++G P P
Sbjct: 13856 TAGAISAPSESTETIICKDEY--EAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPK 13913
Query: 766 ITWCKNNKPVKA--LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+W K K ++ + + T S+ +K KD G YT+ A N G +TV
Sbjct: 13914 SSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTV 13972
Score = 43.2 bits (97), Expect = 0.010
Identities = 32/106 (30%), Positives = 55/106 (51%), Gaps = 8/106 (7%)
Query: 712 AVNREGEASLPIVLKIKTGEKEPPQV-IEPL--KSMIVRQGESVILSAQVVGNPRPTITW 768
A+++ +++ PI K E E P++ ++P +++V GE+ L A V G P PTI W
Sbjct: 17106 AISKPSDSTGPITAK---DEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEW 17162
Query: 769 CKNNKPVK--ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ +K ++ A + D ++ I+K D G Y L+A N G
Sbjct: 17163 LRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAG 17208
Score = 43.2 bits (97), Expect = 0.010
Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 499 EKPTSEE--QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDF 556
EK T+ + ++A + K R +G + +F C +G P P +TW R+ ++ S
Sbjct: 26051 EKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARH 26110
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
Q+ +T I V D G ++ V +N+ G + L ++
Sbjct: 26111 QV-TTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ 26154
Score = 43.2 bits (97), Expect = 0.010
Identities = 18/66 (27%), Positives = 29/66 (43%)
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
+G P P V W + G L + +TT + S I ++ S Y++ N+ G
Sbjct: 26088 DGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEA 26147
Query: 1657 EVTLKV 1662
E TL +
Sbjct: 26148 EFTLTI 26153
Score = 42.7 bits (96), Expect = 0.014
Identities = 31/129 (24%), Positives = 61/129 (47%), Gaps = 12/129 (9%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPV 861
+ +KA N+ G+++ SA + + + P + + F E+ E+GT + +VA++ P
Sbjct: 9592 FRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEV---EEGTNVNIVAKIKGVPF 9648
Query: 862 PSITWYR-------NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
P++TW++ N E + + + + LVI D+G Y A N+ G
Sbjct: 9649 PTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQ-SRRSDTGLYTITAVNNLGT 9707
Query: 915 SSHGARVTI 923
+S R+ +
Sbjct: 9708 ASKEMRLNV 9716
Score = 42.7 bits (96), Expect = 0.014
Identities = 25/120 (20%), Positives = 57/120 (47%), Gaps = 4/120 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE-PPQV---IEPLKSMIVRQGESV 752
+ +++ ++ + + A+N G ++ ++ E+E P E ++++VR G S+
Sbjct: 14238 VPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSI 14297
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ + G P P +TW K+N +K + ++ ++ I+ D G + + EN G
Sbjct: 14298 RIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAG 14357
Score = 42.7 bits (96), Expect = 0.014
Identities = 25/75 (33%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTKSDGDTHSITILKPKKVKDE 800
++I++ GE+ L A V G P PT+ W K+ K ++ A D + + K +D
Sbjct: 14973 TVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDS 15032
Query: 801 GVYTLKAENSEGIAE 815
G YTL A N G A+
Sbjct: 15033 GAYTLTATNPGGFAK 15047
Score = 42.7 bits (96), Expect = 0.014
Identities = 37/154 (24%), Positives = 68/154 (44%), Gaps = 10/154 (6%)
Query: 695 LKITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+++ + + E + + A+N+ G + PI+++ K + +E K + +R G
Sbjct: 16401 IEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAG 16460
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ L + G P P + W K + ++ + + +L D G YTL EN
Sbjct: 16461 GSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLEN 16520
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
S G SA +TV + PP+ + + EIT
Sbjct: 16521 SSG--TKSAFVTVR--VLDTPSPPVNL-KVTEIT 16549
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/135 (24%), Positives = 60/135 (44%), Gaps = 7/135 (5%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE---PPQVIEPLKSMIVRQGESVI 753
I+ + +E + V AVN +G + P L + ++ P V P + V+ E +
Sbjct: 18858 ISGLTAGEEYVFRVAAVNEKGRSD-PRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLK 18916
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAENSE 811
+ G P+ T+ W K+ + +K + + ++T L K+ +D G Y L NS
Sbjct: 18917 IDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSA 18976
Query: 812 G-IAETSAVITVEEP 825
G I +I ++ P
Sbjct: 18977 GSITVPITIIVLDRP 18991
Score = 42.3 bits (95), Expect = 0.018
Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISD 1247
+T + P+ FT L +++ +T + +V+W++ VI T IS
Sbjct: 1 MTTQAPT--FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF 58
Query: 1248 VKKRT-LIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
R L I T+ + Y+ + A ST +L V+ PP V + +++G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
S V L V P P ++ + I+ + S + SL I + D+G Y +
Sbjct: 119 SQVRLQVRVTGIPNPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
N+ G A + + + P K + ++ I+
Sbjct: 179 TNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQIS 214
Score = 41.9 bits (94), Expect = 0.024
Identities = 26/100 (26%), Positives = 40/100 (40%), Gaps = 4/100 (4%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PPT K V EG + LEC + P P + W + +I + + +S +
Sbjct: 896 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGI---- 951
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
+ L I G +T AVN G S L ++ E+
Sbjct: 952 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEE 991
Score = 41.9 bits (94), Expect = 0.024
Identities = 39/131 (29%), Positives = 56/131 (42%), Gaps = 8/131 (6%)
Query: 700 VKKFQEGT---YTVVAVNREGEASLPIVLKIKTGEKEPPQVIE---PLKSMI-VRQGESV 752
VK+ +EG V AVN GE + E + P +E +K I + G+++
Sbjct: 8566 VKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTL 8625
Query: 753 ILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ A V G P PT W K + K + T S I+K KD G Y + A NS
Sbjct: 8626 RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSC 8685
Query: 812 GIAETSAVITV 822
G +A + V
Sbjct: 8686 GSKFAAARVEV 8696
Score = 41.9 bits (94), Expect = 0.024
Identities = 39/133 (29%), Positives = 59/133 (44%), Gaps = 7/133 (5%)
Query: 696 KITNVKKFQEGTYTVVAVNREG--EA-SLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGE 750
+I+ + + QE V A+N+ G EA S+P +K + + P + E K ++VR G
Sbjct: 17484 EISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAGG 17543
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
S + G P P ITW + G ++ + D G Y LK ENS
Sbjct: 17544 SARIHIPFKGRPMPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENS 17603
Query: 811 EGIAETSAVITVE 823
G SA +TV+
Sbjct: 17604 SG--SKSAFVTVK 17614
Score = 41.9 bits (94), Expect = 0.024
Identities = 50/230 (21%), Positives = 94/230 (40%), Gaps = 10/230 (4%)
Query: 702 KFQEGTYTVVA--VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI--VRQGESVILSAQ 757
++Q TY + A V++ EAS PI+ + P+V + +S + + + ++
Sbjct: 22413 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSK 22472
Query: 758 VVGN--PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN--SEGI 813
VVG R ++ + + +K T + ++T L + V A S+G
Sbjct: 22473 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 22532
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
T V +E AE ++ +T++ + L A V P P I W + ++ +
Sbjct: 22533 ESTGPVTCRDEYAPPKAELDARLHG-DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL 22591
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E ++ + G+ VI D DSG Y N++G + V +
Sbjct: 22592 DLCEKVSLQYTGKRATAVIKFCDRS-DSGKYTLTVKNASGTKAVSVMVKV 22640
Score = 41.9 bits (94), Expect = 0.024
Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 5/123 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN-RFQE-ITVKEKGTIKLVARVTRNP 860
+ + A N+ G E + V + TE P ++ R+QE I V++ G I+L + P
Sbjct: 23608 FRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKP 23667
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
P W + + IS I + + ELVI D DSG Y V N GK + +
Sbjct: 23668 FPICKWTKEGQDISKRAMIATS--ETHTELVIKEADRG-DSGTYDLVLENKCGKKAVYIK 23724
Query: 921 VTI 923
V +
Sbjct: 23725 VRV 23727
Score = 41.5 bits (93), Expect = 0.032
Identities = 39/159 (24%), Positives = 63/159 (39%), Gaps = 11/159 (6%)
Query: 450 TSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEK-IDKLPVFEKPTSEEQSM 508
T + W K EE + + L++ Y ++ K +N + K P ++
Sbjct: 9561 TKKEAWRQCNKRDVEELQFT-VEDLVEGGEY-EFRVKAVNAAGVSKPSATVGPCDCQRPD 9618
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD------ 562
P ++ +G+ V +++G P P +TWF+ KP + YD
Sbjct: 9619 MPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPP-KKPDNKEPVLYDTHVNKLV 9677
Query: 563 -DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
D+ TLVI + D G +T A N G AS L V
Sbjct: 9678 VDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9716
Score = 41.5 bits (93), Expect = 0.032
Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--D 799
K++I+R G ++ L V G P P ITW K N ++ T T L+ + V D
Sbjct: 13204 KTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYD 13263
Query: 800 EGVYTLKAENSEGIAETSAVITV 822
G Y L ENS G E + V+ V
Sbjct: 13264 AGKYILTLENSCGKKEYTIVVKV 13286
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/139 (20%), Positives = 61/139 (43%), Gaps = 6/139 (4%)
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
H++T L ++ ++ ++A+N +G++E +T + P + ++ + T+
Sbjct: 23197 HTVTSLNEG---EQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHV 23253
Query: 847 KG--TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDY 904
++LV + P P+ +W+ + SE +T + +L I D+G+Y
Sbjct: 23254 PAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIR-DTGEY 23312
Query: 905 KCVASNSAGKSSHGARVTI 923
N G +S +V I
Sbjct: 23313 TLELKNVTGTTSETIKVII 23331
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/75 (29%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ ++AEN+ GI+E S + + P + + E VK I L A ++ +P P
Sbjct: 8155 FRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLE--VKRGDEIALDASISGSPYP 8212
Query: 863 SITWYRNNEIISPSE 877
+ITW ++ +I P E
Sbjct: 8213 TITWIKDENVIVPEE 8227
Score = 41.1 bits (92), Expect = 0.042
Identities = 33/131 (25%), Positives = 57/131 (43%), Gaps = 5/131 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEK--EPPQVIEP--LKSMIVRQGES 751
+T+++ +E + V A+N G+ S + IK ++ P I+ ++ +VR G S
Sbjct: 21818 VTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGAS 21877
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L G P PT W K + + D+ S ++ D G YTL EN+
Sbjct: 21878 IRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNS 21937
Query: 812 GIAETSAVITV 822
G + + V
Sbjct: 21938 GSKSITFTVKV 21948
Score = 40.7 bits (91), Expect = 0.056
Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 4/91 (4%)
Query: 1575 ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKE 1634
+SN DI +GD ++ + GIP P++ W+ NG L +Y + I
Sbjct: 3463 VSNADIS----MGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILF 3518
Query: 1635 LKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
K +YT ASN G + LK+ K
Sbjct: 3519 TKLEDEGEYTCMASNDYGKTICSAYLKINSK 3549
Score = 40.7 bits (91), Expect = 0.056
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T++ +V+G P P ITW ++ ++ + + D V L I+E D G +
Sbjct: 11426 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRV-ELQIKEAVRADHGKYII 11484
Query: 584 VAKNAAGFASST 595
AKN++G A +
Sbjct: 11485 SAKNSSGHAQGS 11496
Score = 40.7 bits (91), Expect = 0.056
Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 3/78 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV-IREVFPEDAGTFT 582
G ++ E V G PRP I+W + +K Q ++ ++ +T++ I+E +D G +T
Sbjct: 17829 GEDLKIEIPVIGRPRPNISWVKDGEPLK--QTTRVNVEETATSTVLHIKEGNKDDFGKYT 17886
Query: 583 CVAKNAAGFASSTTELIV 600
A N+AG A+ +IV
Sbjct: 17887 VTATNSAGTATENLSVIV 17904
Score = 40.7 bits (91), Expect = 0.056
Identities = 33/125 (26%), Positives = 57/125 (45%), Gaps = 9/125 (7%)
Query: 705 EGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQ 757
E + V +VN+ G ++S P + K + E+EP I E K++IV+ G S ++
Sbjct: 19655 EYVFRVKSVNKVGASDPSDSSDPQIAKER--EEEPLFDIDSEMRKTLIVKAGASFTMTVP 19712
Query: 758 VVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETS 817
G P P + W K + ++ D+ + ++ D G YTL +N A +
Sbjct: 19713 FRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLT 19772
Query: 818 AVITV 822
V+ V
Sbjct: 19773 LVVKV 19777
Score = 40.7 bits (91), Expect = 0.056
Identities = 40/142 (28%), Positives = 66/142 (46%), Gaps = 11/142 (7%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASL----PIVLK--IKTGEKEPPQVIEPLKSMIVRQ 748
++++ +K+ + V A N +G + PI +K I T E + + P + VR
Sbjct: 21023 IEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDI--PGAQVTVRI 21080
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDE--GVYTLK 806
G +V L G P+P+I+W K+ P+K T + L K K E G YT+
Sbjct: 21081 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 21140
Query: 807 AENSE-GIAETSAVITVEEPTE 827
+N+ IA VIT+ P++
Sbjct: 21141 LDNAVCRIAVPITVITLGPPSK 21162
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/78 (25%), Positives = 43/78 (55%), Gaps = 1/78 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G +++ + V+G P P++TWF+ I+ + ++ + +L +R+ + G +T
Sbjct: 21476 GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEI-TNVLGSTSLFVRDATRDHRGVYTV 21534
Query: 584 VAKNAAGFASSTTELIVE 601
AKNA+G A + ++ V+
Sbjct: 21535 EAKNASGSAKAEIKVKVQ 21552
Score = 40.3 bits (90), Expect = 0.074
Identities = 31/127 (24%), Positives = 58/127 (45%), Gaps = 6/127 (4%)
Query: 802 VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-TVKEKGTIKLVARVTRNP 860
+Y + + E+ V T E +E+ + P+ + + TVK TI+L A V P
Sbjct: 11673 IYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKP 11732
Query: 861 VPSITWYRNNEI--ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P + W ++ + ++ S + + ++ + +T D G Y A+N+AG S
Sbjct: 11733 FPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKA-KRSDGGKYVVTATNTAG--SFV 11789
Query: 919 ARVTIDV 925
A T++V
Sbjct: 11790 AYATVNV 11796
Score = 40.3 bits (90), Expect = 0.074
Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ E + G P+P ITW + +K + + D ++ TL I+E +D G +
Sbjct: 16747 GQDLKMEVPISGRPKPTITWTKDGLPLKQTTRINV-TDSLDLTTLSIKETHKDDGGQYGI 16805
Query: 584 VAKNAAGFASSTTELI 599
N G +++ E++
Sbjct: 16806 TVANVVGQKTASIEIV 16821
Score = 40.3 bits (90), Expect = 0.074
Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATLVIREVFPEDAGTF 581
+G + C G P P++TW I + + + ++ D++ TL+I +V +D G +
Sbjct: 26845 EGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLY 26904
Query: 582 TCVAKNAAGFASSTTELIVEA 602
T N G S+T + + +
Sbjct: 26905 TLSLGNEFGSDSATVNIHIRS 26925
Score = 39.9 bits (89), Expect = 0.098
Identities = 28/106 (26%), Positives = 46/106 (43%), Gaps = 6/106 (5%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
I P+ + G D+ +E ++ P P+I+W+ GE + ++V +
Sbjct: 17813 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNV----EETAT 17868
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA--SLPIVLKIKTGEKEPP 735
+VL I K G YTV A N G A +L +++ K G P
Sbjct: 17869 STVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGP 17914
Score = 39.5 bits (88), Expect = 0.13
Identities = 33/134 (24%), Positives = 65/134 (48%), Gaps = 14/134 (10%)
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV----- 1658
V+W+KN KL + I+++ KT + +KE+ S+ + + T+ ++V
Sbjct: 5107 VVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADP 5166
Query: 1659 --TLKVYDKPSKPEGPVIMR-EISRESVTIEWKPPLDDGG--LELTKYAIEKHEPDNNRW 1713
T+K++DK + + + ++ E+S++ V ++W DG + KY+I+
Sbjct: 5167 YFTVKLHDKTAVEKDEITLKCEVSKD-VPVKW---FKDGEEIVPSPKYSIKADGLRRILK 5222
Query: 1714 IKVADVDRDVETYC 1727
IK AD+ E C
Sbjct: 5223 IKKADLKDKGEYVC 5236
Score = 39.5 bits (88), Expect = 0.13
Identities = 26/100 (26%), Positives = 46/100 (46%), Gaps = 4/100 (4%)
Query: 504 EEQSMAPIFVEKLRPKHTP---DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
+EQ P K P HT GS ++ + + G P P++T R +K + F
Sbjct: 19971 KEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEI 20030
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+N+ T+ ++E DAG + A N++G + ++V
Sbjct: 20031 TAENL-TINLKESVTADAGRYEITAANSSGTTKAFINIVV 20069
Score = 39.5 bits (88), Expect = 0.13
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTKSDGDTHSITILKPKKVKDEGVYT 804
R G SV L A + G P PTI W K++K ++ AL + + ++K + G Y
Sbjct: 20388 RAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYE 20447
Query: 805 LKAENSEGIAETSAVITVE 823
LK N+ +A SA I V+
Sbjct: 20448 LKLRNA--MASASATIRVQ 20464
Score = 39.5 bits (88), Expect = 0.13
Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G V E +G P+P I+W + +K S +F + +N TL I+ E G +T
Sbjct: 21081 GHNVHLELPYKGKPKPSISWLKDGLPLKES-EFVRFSKTENKITLSIKNAKKEHGGKYTV 21139
Query: 584 VAKNA 588
+ NA
Sbjct: 21140 ILDNA 21144
Score = 39.1 bits (87), Expect = 0.17
Identities = 34/142 (23%), Positives = 63/142 (44%), Gaps = 9/142 (6%)
Query: 808 ENSEGIAETSAVITVEEPTEENAEP-----PLFINRFQEITVKEKGTIKLVARVTRNPVP 862
E + V+T TEE A P P FI + + E G++ +V NP P
Sbjct: 1006 EEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKP 1065
Query: 863 SITWYRNNEIISPS--ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ W ++ ++ ++ N +LVI+ ++ D+G+Y V N G++S A
Sbjct: 1066 HVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFAD-DAGEYTIVVRNKHGETSASAS 1124
Query: 921 VTIDVEKVTFVKHLQKS-YETE 941
+ + + +K Q+ Y+T+
Sbjct: 1125 LLEEADYELLMKSQQEMLYQTQ 1146
Score = 39.1 bits (87), Expect = 0.17
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNIT-TKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P++ WYK+G ++++ + Y + ++ + +RI + YT ASN G +
Sbjct: 1268 MSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNA 1327
Query: 1655 SVEVTLKVYDKPSKPEG 1671
+ K+Y +P+ P G
Sbjct: 1328 I--CSGKLYVEPAAPLG 1342
Score = 39.1 bits (87), Expect = 0.17
Identities = 39/123 (31%), Positives = 55/123 (44%), Gaps = 8/123 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLK--IKTGE-KEPPQV---IEPLKSMIVRQGE 750
+T++ + QE + V A N+ G P LK IK E EPP++ K +IVR G
Sbjct: 12067 VTSLDENQEYEFRVCAQNQVG-IGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGC 12125
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSD-GDTHSITILKPKKVKDEGVYTLKAEN 809
+ L A V G P P +TW K + D DT + ++ D G Y+L N
Sbjct: 12126 PIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVN 12185
Query: 810 SEG 812
G
Sbjct: 12186 PAG 12188
Score = 38.7 bits (86), Expect = 0.23
Identities = 29/129 (22%), Positives = 54/129 (41%), Gaps = 4/129 (3%)
Query: 796 KVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEP-PLFINRFQEITVKEKGTIKLVA 854
+ K++ + + A N G+ E + + VE E A L + + V+ +I++
Sbjct: 14242 QTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFV 14301
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+ P P +TW ++N + I E+ L+I + D+G + N AGK
Sbjct: 14302 PIKGRPAPEVTWTKDNINLKNRANIENT---ESFTLLIIPECNRYDTGKFVMTIENPAGK 14358
Query: 915 SSHGARVTI 923
S V +
Sbjct: 14359 KSGFVNVRV 14367
Score = 38.7 bits (86), Expect = 0.23
Identities = 56/251 (22%), Positives = 103/251 (41%), Gaps = 28/251 (11%)
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
T K + TY V ++ E ++ + + G EP + EP+K+ L+
Sbjct: 14419 TATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDS-LNIM 14477
Query: 758 VVGNPRPTITWCKNNKP---------VKALPTKSDGDTHSITI------LKPKKVKDEGV 802
+ ++ W K ++A SD TH T+ ++ +E
Sbjct: 14478 DITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYT 14537
Query: 803 YTLKAENSEGIA--ETSAVITVEEPTEENAEPPLFINR-FQEITVKEKG-TIKLVARVTR 858
+ + A NS G + S + V+E T P L + +Q++ + + G IK+ V
Sbjct: 14538 FQVMAVNSAGRSAPRESRPVIVKEQT---MLPELDLRGIYQKLVIAKAGDNIKVEIPVLG 14594
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVIT-NVDSEIDSGDYKCVASNSAGKSSH 917
P P++TW + ++I+ ++ + NF+ ++ N DSG Y A N G+
Sbjct: 14595 RPKPTVTWKKGDQILKQTQRV--NFETTATSTILNINECVRSDSGPYPLTARNIVGEV-- 14650
Query: 918 GARVTIDVEKV 928
G +TI V +
Sbjct: 14651 GDVITIQVHDI 14661
Score = 38.7 bits (86), Expect = 0.23
Identities = 35/145 (24%), Positives = 58/145 (40%), Gaps = 8/145 (5%)
Query: 784 GDTHSITILKPKKV-KDEGVYTLKAENSEGIAET----SAVITVEEPTEENAEPPLFINR 838
G T +T + V K E + +KA+N G +E S+VI E E A+ N
Sbjct: 22099 GHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITN- 22157
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSE 898
Q IT K + ++ P P +TW + ++ ++ + L + +
Sbjct: 22158 -QLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKD-SMR 22215
Query: 899 IDSGDYKCVASNSAGKSSHGARVTI 923
DSG Y N+AG + V +
Sbjct: 22216 GDSGRYFLTLENTAGVKTFSVTVVV 22240
Score = 38.7 bits (86), Expect = 0.23
Identities = 26/104 (25%), Positives = 43/104 (41%), Gaps = 1/104 (0%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +E + H G V + G P P ITW + +I + +Q+ + +
Sbjct: 24531 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVF 24590
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAPLSDHGSEMT 612
V +DAG + AKN G T EL + + P G +++
Sbjct: 24591 PNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVS 24634
Score = 38.3 bits (85), Expect = 0.30
Identities = 43/185 (23%), Positives = 78/185 (42%), Gaps = 20/185 (10%)
Query: 1507 GVPQPKVTWYRDGKKL---KTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G P P+ W+ DG+++ T K + + +A N G
Sbjct: 1436 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1495
Query: 1562 SCVVGI-----QQKPVIT--ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE 1614
S ++ + Q KP+ + N +IK+ ++ E V A G P P+++W KN + +
Sbjct: 1496 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSRL--EMKVRAT--GNPNPDIVWLKNSDIIV 1551
Query: 1615 NDK--EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLKVYDKPSKPE 1670
K + I + + ++I S+ YT A N AG T+ +V ++V +PE
Sbjct: 1552 PHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPE 1611
Query: 1671 GPVIM 1675
+I+
Sbjct: 1612 RKLII 1616
Score = 38.3 bits (85), Expect = 0.30
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 9/97 (9%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK--NNKPVKALPTKSDGDTHSI--- 789
P I+ + M V +G +V + A++ G P PT+TW K KP P D + +
Sbjct: 9620 PPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD 9679
Query: 790 ---TILKPK-KVKDEGVYTLKAENSEGIAETSAVITV 822
T++ P+ + D G+YT+ A N+ G A + V
Sbjct: 9680 DTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9716
Score = 38.3 bits (85), Expect = 0.30
Identities = 49/181 (27%), Positives = 78/181 (43%), Gaps = 13/181 (7%)
Query: 640 PKAQY-VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKIT 698
P AQ V G ++ LE P+P I+WL G + E + + + L I
Sbjct: 21072 PGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENK----ITLSIK 21127
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQV 758
N KK G YTV+ N ++PI + I G P+ P++ ++ +SVILS V
Sbjct: 21128 NAKKEHGGKYTVILDNAVCRIAVPITV-ITLGPPSKPK--GPIRFDEIK-ADSVILSWDV 21183
Query: 759 VGNPRPTITWCKNNKPVKALPTKSDGDTHSI---TILKPKKVKD-EGVYTLKAENSEGIA 814
+ C + + + T S+ T P VKD E + ++AEN G++
Sbjct: 21184 PEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYGVS 21243
Query: 815 E 815
+
Sbjct: 21244 Q 21244
Score = 38.3 bits (85), Expect = 0.30
Identities = 21/70 (30%), Positives = 34/70 (48%), Gaps = 3/70 (4%)
Query: 1592 VTAVIEG--IPPPEVIWYKNGNKLENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEAS 1648
+T V+E + EV WYK+G KL+ + + + + T ++I L S +Y E S
Sbjct: 26238 LTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEIS 26297
Query: 1649 NTAGTSSVEV 1658
GTS +
Sbjct: 26298 GEGGTSKTNL 26307
Score = 37.9 bits (84), Expect = 0.39
Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV+F + G P P W + IK + + + D+ + + L I+ D G +
Sbjct: 11028 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFS-SVLTIKNCLRRDTGEYQI 11086
Query: 584 VAKNAAGFASSTTELIV 600
NAAG + L V
Sbjct: 11087 TVSNAAGSKTVAVHLTV 11103
Score = 37.9 bits (84), Expect = 0.39
Identities = 32/156 (20%), Positives = 69/156 (44%), Gaps = 10/156 (6%)
Query: 673 EIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
+ + +EN + + + S +T K++ T+ V A N GE + + + +
Sbjct: 13424 DFLTEENKWQRVMKSLSLQYSAKDLTEGKEY---TFRVSAENENGEGTPSEITVVARDDV 13480
Query: 733 EPPQV-IEPLKSM--IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI 789
P + ++ L + + ++ + L + G P P+++W K P+ A T+ ++ ++
Sbjct: 13481 VAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPL-ATDTRVSVESSAV 13539
Query: 790 T---ILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
I+ + D G YT+ +N G E + I V
Sbjct: 13540 NTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 13575
Score = 37.9 bits (84), Expect = 0.39
Identities = 24/116 (20%), Positives = 46/116 (39%), Gaps = 5/116 (4%)
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEIT--VKEKGTIKLVARVT 857
E + + AEN G S + V ++ P L + ++ KE +L +
Sbjct: 13453 EYTFRVSAENENGEGTPSEITVVAR--DDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIK 13510
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P PS++W + + ++ ++ N L++ + D+G Y N AG
Sbjct: 13511 GKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKS-DAGKYTITLKNVAG 13565
Score = 37.9 bits (84), Expect = 0.39
Identities = 37/131 (28%), Positives = 59/131 (45%), Gaps = 9/131 (6%)
Query: 798 KDEGVYTLKAENSEGIAETSAV---ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
K E + + A N G+ E + V I VEE E + L + + I ++ G+++L
Sbjct: 16409 KHEYNFRICAINKAGVGEHADVPGPIIVEEKLEA-PDIDLDLELRKIINIRAGGSLRLFV 16467
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+ P P + W + + I + I + LV+ NV + DSG Y NS+G
Sbjct: 16468 PIKGRPTPEVKWGKVDGEIRDAAII--DVTSSFTSLVLDNV-NRYDSGKYTLTLENSSGT 16524
Query: 915 SSHGARVTIDV 925
S A VT+ V
Sbjct: 16525 KS--AFVTVRV 16533
Score = 37.9 bits (84), Expect = 0.39
Identities = 36/141 (25%), Positives = 63/141 (44%), Gaps = 9/141 (6%)
Query: 789 ITILKPKKVKDEGVYTLK--AENSEGIAETSAVITVEEPTEENAEPPLFINRF--QEITV 844
+T + K+ + Y ++ A N G+ E ++V +P ++ P L ++ + I V
Sbjct: 17480 VTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVV 17539
Query: 845 KEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDY 904
+ G+ ++ P+P ITW R + I + + +L I N D D+G Y
Sbjct: 17540 RAGGSARIHIPFKGRPMPEITWSREEGEFTDKVQIEKGVN--YTQLSIDNCDRN-DAGKY 17596
Query: 905 KCVASNSAGKSSHGARVTIDV 925
NS+G S A VT+ V
Sbjct: 17597 ILKLENSSGSKS--AFVTVKV 17615
Score = 37.5 bits (83), Expect = 0.52
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 9/109 (8%)
Query: 509 APIFVEKLRPKHT------PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
A +FVE L T P+ T FEC+V + P + W + I+ S+ F++
Sbjct: 2829 AKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVV-Q 2886
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASST-TELIVEAPLSDHGSE 610
+ L+I ED+ +T V N A+ T T +++ + L D +E
Sbjct: 2887 GKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLKDINAE 2935
Score = 37.5 bits (83), Expect = 0.52
Identities = 20/81 (24%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ E V G P P W + + S ++ D + + L+I++V +D+G ++
Sbjct: 12416 GKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSS-SILIIKDVTRKDSGYYSL 12474
Query: 584 VAKNAAGFASSTTELIV-EAP 603
A+N++G + +++V +AP
Sbjct: 12475 TAENSSGTDTQKIKVVVMDAP 12495
Score = 37.5 bits (83), Expect = 0.52
Identities = 29/125 (23%), Positives = 54/125 (43%), Gaps = 5/125 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFI---NRFQEITVKEKGTIKLVA-RVTR 858
+ ++A+N+ G + T ++ E P + +T+K TI L A +
Sbjct: 13849 FRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILG 13908
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P+P +W + + I PS+ ITQ ++ + D+G+Y A+N G
Sbjct: 13909 KPLPKSSWSKAGKDIRPSD-ITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH 13967
Query: 919 ARVTI 923
+VT+
Sbjct: 13968 VKVTV 13972
Score = 37.5 bits (83), Expect = 0.52
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 3/68 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV-IREVFPEDAGTFT 582
G ++ E V G P+P +TW + I+K +Q ++ ++ +T++ I E D+G +
Sbjct: 14583 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQ--RVNFETTATSTILNINECVRSDSGPYP 14640
Query: 583 CVAKNAAG 590
A+N G
Sbjct: 14641 LTARNIVG 14648
Score = 37.5 bits (83), Expect = 0.52
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 4/88 (4%)
Query: 838 RFQEITVKEKG-TIKLVARVTRNPVPSITWYR-NNEIISPSETITQNFDGENIELVITNV 895
+F++ V G T +L A V P+P+I W R + EI + +N D + L+I
Sbjct: 17133 KFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFK--ALLIVKD 17190
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTI 923
ID G Y ASN AG S V +
Sbjct: 17191 AIRIDGGQYILRASNVAGSKSFPVNVKV 17218
Score = 37.5 bits (83), Expect = 0.52
Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T + E V G P P I W R I+ S ++ + D A L++++ D G +
Sbjct: 17143 GETFRLEADVHGKPLPTIEWLRGDKEIEESARCEI-KNTDFKALLIVKDAIRIDGGQYIL 17201
Query: 584 VAKNAAGFAS 593
A N AG S
Sbjct: 17202 RASNVAGSKS 17211
Score = 37.5 bits (83), Expect = 0.52
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 13/125 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREG---EASLPIVLKIKTGEKEPPQV---IEPLKSMIVRQGE 750
+T +K+ E + + A+N EG A+LP + + EPP++ + K +++R
Sbjct: 18568 VTKLKENTEYNFRICAINSEGVGEPATLPGSV-VAQERIEPPEIELDADLRKVVVLRASA 18626
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGD-THSITILKPKKVK--DEGVYTLKA 807
++ L + G P P + W K L ++ + T S T+L V D G Y L
Sbjct: 18627 TLRLFVTIKGRPEPEVKW---EKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTL 18683
Query: 808 ENSEG 812
EN+ G
Sbjct: 18684 ENNSG 18688
Score = 37.5 bits (83), Expect = 0.52
Identities = 17/73 (23%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKE--YNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
V G P PEV W G K+ + ++ ++I + + + I ++++ YT+ N
Sbjct: 26851 VACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 26910
Query: 1650 TAGTSSVEVTLKV 1662
G+ S V + +
Sbjct: 26911 EFGSDSATVNIHI 26923
Score = 37.1 bits (82), Expect = 0.69
Identities = 15/50 (30%), Positives = 24/50 (48%)
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
I E++ + +KN + C G P PK+ WY+DGK++K
Sbjct: 1237 ISESEAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK 1286
Score = 37.1 bits (82), Expect = 0.69
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 5/72 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFR-QTAIIKPSQDFQMYYDD----DNVATLVIREVFPEDA 578
G V V G P P+I W + +T I KP+ Q+ ++ + L I + ED
Sbjct: 8916 GEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDK 8975
Query: 579 GTFTCVAKNAAG 590
GT+T A N G
Sbjct: 8976 GTYTVTASNRLG 8987
Score = 37.1 bits (82), Expect = 0.69
Identities = 30/120 (25%), Positives = 51/120 (42%), Gaps = 7/120 (5%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPP---LFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A NSEG+ E A++ E+ PP L + + +T++ T++L + P P
Sbjct: 15336 AMNSEGLGEP-ALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPDPE 15394
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ W R++ +I + L+I + DSG Y NS+G S V +
Sbjct: 15395 VKWARDHGESLDKASIE---SASSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRV 15451
Score = 36.7 bits (81), Expect = 0.91
Identities = 23/58 (39%), Positives = 28/58 (48%), Gaps = 4/58 (6%)
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN---SKCTAI-LTV 1191
+W DGSEI+ H + D L I +C D GEY V N SK A+ LTV
Sbjct: 11046 KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTV 11103
Score = 36.7 bits (81), Expect = 0.91
Identities = 21/86 (24%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 839 FQEITVKEKGT-IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDS 897
+ E+ GT +KL A ++ P P+I WY++++ + + + + ++I + D
Sbjct: 20381 YTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDAD- 20439
Query: 898 EIDSGDYKCVASNSAGKSSHGARVTI 923
++SG Y+ N+ +S RV I
Sbjct: 20440 RLNSGCYELKLRNAMASASATIRVQI 20465
Score = 36.3 bits (80), Expect = 1.2
Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 8/107 (7%)
Query: 822 VEEPT--EENAEPPLFI---NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
V EP ++ EPP I N +E +K T++L A + P P +TW + +
Sbjct: 10706 VPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTK 10765
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
I G +E I N E D G Y N AG + +V +
Sbjct: 10766 ARIDVTPVGSKLE--IRNAAHE-DGGIYSLTVENPAGSKTVSVKVLV 10809
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G+ + + +P P W G EI DE+ +V E+D + SVL I N +
Sbjct: 11025 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTV--ETD--NFSSVLTIKNCLRRD 11080
Query: 705 EGTYTVVAVNREGEASLPIVLKI 727
G Y + N G ++ + L +
Sbjct: 11081 TGEYQITVSNAAGSKTVAVHLTV 11103
Score = 36.3 bits (80), Expect = 1.2
Identities = 20/77 (25%), Positives = 35/77 (45%), Gaps = 1/77 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ + G P P +TW + +K + ++N + L I++ ED G +
Sbjct: 15665 GEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENN-SLLTIKDACREDVGHYVV 15723
Query: 584 VAKNAAGFASSTTELIV 600
N+AG A T +IV
Sbjct: 15724 KLTNSAGEAIETLNVIV 15740
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/82 (28%), Positives = 35/82 (42%), Gaps = 3/82 (3%)
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD-GDTHSITILKPKKV--KDE 800
++V GE+ +L A + G P P + W K+ K ++ + + T T L K D
Sbjct: 18220 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 18279
Query: 801 GVYTLKAENSEGIAETSAVITV 822
G Y LK N G + V
Sbjct: 18280 GQYILKLSNVGGTKSIPITVKV 18301
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/81 (28%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS + + V G P P+I W + + + + Y AT VI+ D+G +T
Sbjct: 22565 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKR-ATAVIKFCDRSDSGKYTL 22623
Query: 584 VAKNAAGF-ASSTTELIVEAP 603
KNA+G A S ++++P
Sbjct: 22624 TVKNASGTKAVSVMVKVLDSP 22644
Score = 35.9 bits (79), Expect = 1.6
Identities = 27/79 (34%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQIT-WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
GS+ FEC V P IT W + + I+ S + D + L I +V DAG +T
Sbjct: 4636 GSSAIFECLVS--PSTAITTWMKDGSNIRESPKHRFIADGKD-RKLHIIDVQLSDAGEYT 4692
Query: 583 CVAKNAAGFASSTTELIVE 601
CV + +ST +L+VE
Sbjct: 4693 CVLRLGNKEKTSTAKLVVE 4711
Score = 35.9 bits (79), Expect = 1.6
Identities = 13/33 (39%), Positives = 22/33 (66%)
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
S+ V++G+ + L A + G+P PTITW K+ +
Sbjct: 8191 SLEVKRGDEIALDASISGSPYPTITWIKDENVI 8223
Score = 35.9 bits (79), Expect = 1.6
Identities = 29/134 (21%), Positives = 55/134 (41%), Gaps = 5/134 (3%)
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIK 851
+K K D Y + A N G + S +E A P L ++ ++T++
Sbjct: 10281 VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFA 10340
Query: 852 LVARVTRNPVPSITWYRNN-EIISPSETITQNFDGENIELVITNVDSE-IDSGDYKCVAS 909
L R + P P ++W+++ +++ T + L + + ++ DSG Y V
Sbjct: 10341 LTGRYSGKPKPKVSWFKDEADVLEDDRT---HIKTTPATLALEKIKAKRSDSGKYCVVVE 10397
Query: 910 NSAGKSSHGARVTI 923
NS G +V +
Sbjct: 10398 NSTGSRKGFCQVNV 10411
Score = 35.9 bits (79), Expect = 1.6
Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 10/86 (11%)
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKN-------NKPVKALPTKSDGDTHSITILKPKK 796
+ V+ G+++ L A V G P P + W K+ P + T++D S+T K K+
Sbjct: 11714 LTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLT--KAKR 11771
Query: 797 VKDEGVYTLKAENSEGIAETSAVITV 822
D G Y + A N+ G A + V
Sbjct: 11772 -SDGGKYVVTATNTAGSFVAYATVNV 11796
Score = 35.9 bits (79), Expect = 1.6
Identities = 14/53 (26%), Positives = 28/53 (52%)
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+V WY +LEN ++Y IT ++ +++ +K++ + Y + N G S
Sbjct: 25102 QVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDS 25154
Score = 35.5 bits (78), Expect = 2.1
Identities = 26/113 (23%), Positives = 51/113 (45%), Gaps = 10/113 (8%)
Query: 958 TKWYHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVV 1012
T W+H+ ++I + H+ +I+E D G + +++ S +L V
Sbjct: 1442 TFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTV 1501
Query: 1013 K----ETIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKK 1060
+ + P F+ KL++ +KE ++V D+VW ++ +II P K
Sbjct: 1502 EAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHK 1554
Score = 35.5 bits (78), Expect = 2.1
Identities = 22/98 (22%), Positives = 42/98 (42%), Gaps = 3/98 (3%)
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+QKP I + E ++ G+ + G P P+V WY NG + K + + +
Sbjct: 1792 KQKPDIVLYPEPVRVLE--GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV-RYDGI 1848
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
+ I + K + + + A N G +V L++ +
Sbjct: 1849 HYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQR 1886
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/103 (24%), Positives = 46/103 (44%), Gaps = 7/103 (6%)
Query: 505 EQSMAPIF---VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
E+ MAP F E R G +++ ++G P P++TW + +K + + +
Sbjct: 14272 EREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIE---N 14328
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
++ L+I E D G F +N AG S + +++ P
Sbjct: 14329 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTP 14371
Score = 35.5 bits (78), Expect = 2.1
Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 8/107 (7%)
Query: 634 PTFSKKPKAQ---YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
P S PK + V G +LE + P PD+ W G+E+ E + +E +
Sbjct: 18208 PNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKEL---EETAARMEIKSTI 18264
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI--KTGEKEPP 735
+ L + + + G Y + N G S+PI +K+ + G E P
Sbjct: 18265 QKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGSPEGP 18311
Score = 35.5 bits (78), Expect = 2.1
Identities = 24/101 (23%), Positives = 39/101 (38%), Gaps = 1/101 (0%)
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
P I ++ K G L P P+ +W K + + + K S D ++ +LT+
Sbjct: 24036 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTV 24095
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-PPGKP 1387
E D G+Y N G + + + P PG P
Sbjct: 24096 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP 24136
Score = 35.5 bits (78), Expect = 2.1
Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 4/80 (5%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEI-NSETADVVWERDG-EIIKPKKNKYDFEKRGHIRKL 1074
P ++++D K + A L +I D+ W R G E+I+ +K K + R H L
Sbjct: 24036 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT--L 24093
Query: 1075 YIRNTSVHDEGEYSCILRDE 1094
+ DEG Y+CI +E
Sbjct: 24094 TVMTEEQEDEGVYTCIATNE 24113
Score = 35.1 bits (77), Expect = 2.8
Identities = 37/161 (22%), Positives = 67/161 (41%), Gaps = 12/161 (7%)
Query: 446 YILD--TSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDKLPVFEKPTS 503
Y++D T W V K L+ + A+ L + YT + + NE + P +
Sbjct: 13421 YVVDFLTEENKWQRVMKSLSLQYS---AKDLTEGKEYTFRVSAE-NENGEGTPSEITVVA 13476
Query: 504 EEQSMAPIFVEKLRPKH---TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
+ +AP K P + S + + ++G P P ++W + + + D ++
Sbjct: 13477 RDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPL--ATDTRVSV 13534
Query: 561 DDDNV-ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ V TL++ + DAG +T KN AG T + V
Sbjct: 13535 ESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKV 13575
Score = 35.1 bits (77), Expect = 2.8
Identities = 19/81 (23%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS + + G P P++TW + +K + + D TL +++ D+G +
Sbjct: 22165 GSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDR-TTLTVKDSMRGDSGRYFL 22223
Query: 584 VAKNAAGFAS-STTELIVEAP 603
+N AG + S T +++ P
Sbjct: 22224 TLENTAGVKTFSVTVVVIGRP 22244
Score = 35.1 bits (77), Expect = 2.8
Identities = 24/90 (26%), Positives = 43/90 (47%), Gaps = 5/90 (5%)
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT---ILKPKK 796
P K++ V G V L + G P P +W ++ + +TH+ ++
Sbjct: 23247 PQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRE-SERVTVETHTKVAKLTIRETT 23305
Query: 797 VKDEGVYTLKAENSEG-IAETSAVITVEEP 825
++D G YTL+ +N G +ET VI +++P
Sbjct: 23306 IRDTGEYTLELKNVTGTTSETIKVIILDKP 23335
Score = 35.1 bits (77), Expect = 2.8
Identities = 39/180 (21%), Positives = 74/180 (41%), Gaps = 17/180 (9%)
Query: 1218 VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
+E D++ VTWY +E++EK+ + + L ++ T+ D Y C +++
Sbjct: 25094 IENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGED 25153
Query: 1278 KLKVEV-VEFPPKIVDY---EREYRIKRGSDVTLLVDYQ---AFPQPNDEWIVNSKI--- 1327
E+ V+ ++ DY +IKR +D L++ P N V +
Sbjct: 25154 SSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFG 25213
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVEN-------TDAGIYKLRLENNCGHADVEMNVTILDK 1380
+ H +P + + IK +N +D G+Y+L + + D E V +K
Sbjct: 25214 VTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 25273
Score = 34.7 bits (76), Expect = 3.7
Identities = 25/121 (20%), Positives = 53/121 (43%), Gaps = 2/121 (1%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ +KA N +G ++ + + +P L + F +++ +K+ V P P
Sbjct: 17786 FRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLP-FNTYSIQAGEDLKIEIPVIGRPRP 17844
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+I+W ++ E + + + + L I + + D G Y A+NSAG ++ V
Sbjct: 17845 NISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKD-DFGKYTVTATNSAGTATENLSVI 17903
Query: 923 I 923
+
Sbjct: 17904 V 17904
Score = 34.7 bits (76), Expect = 3.7
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 641 KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNV 700
K + G+ + L + P P I W +G ++ S AI Y S+L + V
Sbjct: 22957 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLA-----SRAIIDTTESY-SLLIVDKV 23010
Query: 701 KKFQEGTYTVVAVNREGEASLPIVLKI 727
++ G YT+ A N+ G+ S +++K+
Sbjct: 23011 NRYDAGKYTIEAENQSGKKSATVLVKV 23037
Score = 34.3 bits (75), Expect = 4.9
Identities = 22/94 (23%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
PT + V EG + + A+P P ++W G+E+ + ++ +++D H+ +
Sbjct: 7890 PTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLT--MKND-HI-SA 7945
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L++ + G YT+ N+ G A+ I +K+
Sbjct: 7946 HLEVPKSVRADAGIYTITLENKLGSATASINVKV 7979
Score = 34.3 bits (75), Expect = 4.9
Identities = 37/130 (28%), Positives = 54/130 (41%), Gaps = 11/130 (8%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN---RFQEITVKEKGTIKLVARVTRN 859
+ +KA N G +E S + V +E P + + R I VK + + A VT
Sbjct: 8870 FRVKAVNEIGESEPSLPLNVVIQDDE-VPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGL 8928
Query: 860 PVPSITWYRNNEII-SPSET--ITQ---NFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P+P I W +N +I P++ IT+ + EL I E D G Y ASN G
Sbjct: 8929 PMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRE-DKGTYTVTASNRLG 8987
Query: 914 KSSHGARVTI 923
V +
Sbjct: 8988 SVFRNVHVEV 8997
Score = 34.3 bits (75), Expect = 4.9
Identities = 26/120 (21%), Positives = 52/120 (43%), Gaps = 4/120 (3%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFIN--RFQEITVKEKG-TIKLVARVTRNPVPS 863
A N+ G+ + T + +PP ++++ V G + K+ A + P+P+
Sbjct: 16018 ARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPT 16077
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
I W + ++ +S + + L + + +DSG+Y A N AG+ S V +
Sbjct: 16078 IQWIKGDQELSNTARLEIKSTDFATSLSVKDA-VRVDSGNYILKAKNVAGERSVTVNVKV 16136
Score = 34.3 bits (75), Expect = 4.9
Identities = 25/100 (25%), Positives = 39/100 (39%), Gaps = 4/100 (4%)
Query: 727 IKTGEKEPPQVIEPLKSMIV--RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG 784
IK + EP + + + ++ + G + + G P P +TW +K S
Sbjct: 22141 IKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSIT 22200
Query: 785 DTHSITIL--KPKKVKDEGVYTLKAENSEGIAETSAVITV 822
T T L K D G Y L EN+ G+ S + V
Sbjct: 22201 TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVV 22240
Score = 34.3 bits (75), Expect = 4.9
Identities = 18/67 (26%), Positives = 28/67 (41%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
++ P EV WY NG +L+ + + T + I + S Y +N G +S
Sbjct: 25900 VQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEAS 25959
Query: 1656 VEVTLKV 1662
TL V
Sbjct: 25960 DYATLDV 25966
Score = 33.9 bits (74), Expect = 6.4
Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 2/64 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T F+C++ Y + W+ + ++PS D + + V TL +R+V EDAG
Sbjct: 5713 GETATFDCELS-YEDIPVEWYLKGKKLEPS-DKVVPRSEGKVHTLTLRDVKLEDAGEVQL 5770
Query: 584 VAKN 587
AK+
Sbjct: 5771 TAKD 5774
Score = 33.9 bits (74), Expect = 6.4
Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 517 RPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT-LVIREVFP 575
R +H G T++ ++G P P++TW ++ + D V + L IR
Sbjct: 10729 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDR----DAPTKARIDVTPVGSKLEIRNAAH 10784
Query: 576 EDAGTFTCVAKNAAGFASSTTELIV 600
ED G ++ +N AG + + +++V
Sbjct: 10785 EDGGIYSLTVENPAGSKTVSVKVLV 10809
Score = 33.9 bits (74), Expect = 6.4
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 3/72 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G++++ V G P P ITW +Q I S+ + ++ + L++ +V DAG +T
Sbjct: 22964 GASLRLMVSVSGRPPPVITWSKQ-GIDLASR--AIIDTTESYSLLIVDKVNRYDAGKYTI 23020
Query: 584 VAKNAAGFASST 595
A+N +G S+T
Sbjct: 23021 EAENQSGKKSAT 23032
Score = 33.9 bits (74), Expect = 6.4
Identities = 17/54 (31%), Positives = 28/54 (51%)
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
WF GS+++ S + + K KL I + + D GEY+ E+ N T T++
Sbjct: 23275 WFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIK 23328
Score = 33.5 bits (73), Expect = 8.5
Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 15/131 (11%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVL-KIK-TGEKEPPQVIEPLKS---MIVRQGES 751
+ N+K+ ++ + V AVN GE+ +I T +E P+V + + ++ + G
Sbjct: 9271 VPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQ 9330
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKA-------LPTKSDGDT---HSITILKPKKVKDEG 801
+ + A + G P P +W + K KA +P + +T S+ I+ K G
Sbjct: 9331 IRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTG 9390
Query: 802 VYTLKAENSEG 812
Y++ A+N G
Sbjct: 9391 KYSITAKNKAG 9401
Score = 33.5 bits (73), Expect = 8.5
Identities = 31/130 (23%), Positives = 53/130 (40%), Gaps = 9/130 (6%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN-RFQEITVKEKGT-IKLVARVTRNP 860
+ +KA N G +E S T+ EP +FI+ Q+ V + G+ I++ A + P
Sbjct: 9282 FRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRP 9341
Query: 861 VPSITWYRNNEI-------ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P +W + + + Q EN ++I +G Y A N AG
Sbjct: 9342 TPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAG 9401
Query: 914 KSSHGARVTI 923
+ + RV +
Sbjct: 9402 QKTANCRVKV 9411
Score = 33.5 bits (73), Expect = 8.5
Identities = 25/106 (23%), Positives = 47/106 (44%), Gaps = 7/106 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PP P+ + G + +E + P P W +E+V +++V ++D
Sbjct: 12401 LPPKILM-PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVH-KADS--- 12455
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPP 735
S+L I +V + G Y++ A N G + +V+ G +PP
Sbjct: 12456 SSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPP 12501
Score = 33.5 bits (73), Expect = 8.5
Identities = 18/69 (26%), Positives = 31/69 (44%), Gaps = 1/69 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + E V G P P + W + ++ + ++ D + LV ++ D+G +T
Sbjct: 14979 GEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKDSTRRDSGAYTL 15037
Query: 584 VAKNAAGFA 592
A N GFA
Sbjct: 15038 TATNPGGFA 15046
Score = 33.5 bits (73), Expect = 8.5
Identities = 53/198 (26%), Positives = 78/198 (39%), Gaps = 22/198 (11%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G D+ +E + P+P I W G + I+V D+ + L I K
Sbjct: 16744 VQVGQDLKMEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDL----TTLSIKETHKDD 16799
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G Y + N G+ + I + + + +PP+ P+K V ES+ LS NP
Sbjct: 16800 GGQYGITVANVVGQKTASIEI-VTLDKPDPPK--GPVKFDDV-SAESITLS----WNPPL 16851
Query: 765 TITWCK--NNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYTLK--AENSEG--IA 814
C+ N K T + D S T+ LK K+K Y + AEN G A
Sbjct: 16852 YTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFA 16911
Query: 815 ETSAVITVEEPTEENAEP 832
S I + P +E P
Sbjct: 16912 LESDPIVAQYPYKEPGPP 16929
Score = 33.5 bits (73), Expect = 8.5
Identities = 21/80 (26%), Positives = 42/80 (52%), Gaps = 4/80 (5%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
GSD++L+ + PEP I W KG++ + D V+++ +V+K + + G
Sbjct: 22565 GSDLVLDAAVGGKPEPKIIWT-KGDKEL-DLCEKVSLQYTGKRATAVIKFCD--RSDSGK 22620
Query: 708 YTVVAVNREGEASLPIVLKI 727
YT+ N G ++ +++K+
Sbjct: 22621 YTLTVKNASGTKAVSVMVKV 22640
>X90569-1|CAA62189.1| 7962|Homo sapiens elastic titin protein.
Length = 7962
Score = 263 bits (644), Expect = 6e-69
Identities = 273/1197 (22%), Positives = 473/1197 (39%), Gaps = 92/1197 (7%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
+ + P F KL+ H G V FEC++ G Q++W++ ++K + Q + NV
Sbjct: 3777 RKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSF-VHNV 3835
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXX 625
ATL I + G + C A N G ASS+ +LI LS+H
Sbjct: 3836 ATLQILQTDQSHIGQYNCSASNPLGTASSSAKLI----LSEH------------------ 3873
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
+PP F KP + + G +C + I W EI P N + +
Sbjct: 3874 -----EVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLV 3928
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLK-SM 744
+ + L + V K G YT A N G+ S L G +EPP+ I+ L+ S
Sbjct: 3929 EN----TATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQL----GVQEPPRFIKKLEPSR 3980
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK--KVKDEGV 802
IV+Q E ++ G+P + W K+ ++ S+ +L+ V+D G
Sbjct: 3981 IVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGD 4040
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
YT +A N+ G A +S + V+ EPP+F + I + + L + P
Sbjct: 4041 YTCEAHNAAGSASSSTSLKVK-------EPPIFRKKPHPIETLKGADVHLECELQGTPPF 4093
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
++WY++ + + + + I NVD+ D G+Y+C A+N G + +
Sbjct: 4094 HVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDA-ADIGEYQCKATNDVGSDTCVGSIA 4152
Query: 923 IDVEKVTFVKHLQKSYETEEGKTVILE--CQTSHTVSTKWYHNKKEI-SGMDHREIIQEG 979
+ FVK L T GK V L+ + + +S W+ +K EI D+ I
Sbjct: 4153 LKAPP-RFVKKL-SDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSE 4210
Query: 980 RXXXXXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQDFEVKEKDVAI 1035
+ G C +K+ QE L V E + K + +V D
Sbjct: 4211 NIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEP-ATIVEKPESIKVTTGDTCT 4269
Query: 1036 LEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD- 1093
LE + + W +DG+ + NKY + L I N + D G YS +++
Sbjct: 4270 LECTVAGTPELSTKWFKDGKEL-TSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNP 4328
Query: 1094 ---ESCTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQ 1147
+SCTA + V + +PP +L+ G+ E ++ + V WF +G+EI
Sbjct: 4329 VGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEIS 4388
Query: 1148 FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLP 1203
Q T+ L + + D+G+Y+C G+ +C+A LTV EP P
Sbjct: 4389 SGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDP 4448
Query: 1204 EFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
+L N + ++ V+W+K S + ++ + + L +
Sbjct: 4449 MDVLTGTNV-TFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQS 4507
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
EYTC++ + + ++ P K V +Y I++G + L + P + W
Sbjct: 4508 GEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWK 4567
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP- 1381
N + + + KS L I DAG Y +EN G + IL+ P
Sbjct: 4568 KNGINVTPSQRCNITTTEKSPILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPY 4627
Query: 1382 -SPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTS 1439
+P + + S+ C + T + +Y + + TT + + +N T
Sbjct: 4628 FVKQLEPVKVSVGDSASLQC--QLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLV- 4684
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDI 1499
+ N S + A N V + S +T + ++E K+ P+ + L+++ +
Sbjct: 4685 FNQVDINDSGEYICKAENSV--GEVSAST--FLTVQEQKL-PPSFSRQLRDVQETVGLPV 4739
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTA----KATYENRXXXXXXXXXXXXXXXYKCIAFND 1555
C G V+WY+DGK LK + + +N Y C A N
Sbjct: 4740 VFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNP 4799
Query: 1556 HGEVETSCVVGI---QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
G +S + + + P I + VG+ + G P +V W K+ +
Sbjct: 4800 IGSASSSARLILTEGKNPPFFDIRLAPVDA--VVGESADFECHVTGTQPIKVSWAKDSRE 4857
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
+ + +Y I+ E ++ + + ++ + S +YT A N G S L + ++ P
Sbjct: 4858 IRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPP 4914
Score = 262 bits (641), Expect = 1e-68
Identities = 273/1193 (22%), Positives = 473/1193 (39%), Gaps = 67/1193 (5%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P E P + L+ T +G +F+C+V G +++W+ + IKPS+ F+M
Sbjct: 1 PDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQ 59
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
+D L I E +PED GT+T VA NA G SST L +EAP S
Sbjct: 60 FEDTYQ-LEIAEAYPEDEGTYTFVANNAVGQVSSTANLSLEAPES-----------ILHE 107
Query: 621 XXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI 680
++ P +K + V G C + + P W G EI +
Sbjct: 108 RIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKC 167
Query: 681 SVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEP 740
S+ Y S L+I + G YT A N G S L + E PP +
Sbjct: 168 SIRSSK----YISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVT--EAYPPTFLSR 221
Query: 741 LKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPT--KSDGDTHSITILKPKKVK 798
KS+ G++ V G P W K+ + P SD + I L ++
Sbjct: 222 PKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQ 281
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
D GVY+ KA N G A + + + P FI + + + L +V
Sbjct: 282 DRGVYSCKASNKFGADICQAELII-------IDKPHFIKELEPVQSAINKKVHLECQVDE 334
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
+ ++TW ++ + + P + F+ + L I + DSG Y C ASN AG SS
Sbjct: 335 DRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLK-DSGTYVCTASNEAGSSSCS 393
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREII 976
A VT+ E +FVK + SY G++ L C+ S + W+ N KE+S + +
Sbjct: 394 ATVTVR-EPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMY 452
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKD---QETSTMLVVKETIPEFIRKLQDFEVKEKD 1032
D G C V D ST +V+KE P FI+ L+ ++
Sbjct: 453 FVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEP-PSFIKTLEPADIVRGT 511
Query: 1033 VAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
A+L+ E++ + ++ W +D + I+ K KY + + L I + + D GEY C++
Sbjct: 512 NALLQCEVSGTGPFEISWFKDKKQIRSSK-KYRLFSQKSLVCLEIFSFNSADVGEYECVV 570
Query: 1092 RDE--SCTAEVT-VVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQ 1147
+E C T +++ PP + ++ + G T + + + + V W K I+
Sbjct: 571 ANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIR 630
Query: 1148 FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLP 1203
I+++ L I D + G+Y+C E G+ L V+EP+ +
Sbjct: 631 EDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPA--KIIERA 688
Query: 1204 EFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
E I V A A L + L WYK + ++K+ + L D
Sbjct: 689 ELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHD 748
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDV--TLLVDYQ-AFPQP-N 1318
+YT + + ++ + I + + S V T +D + A P
Sbjct: 749 SGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMR 808
Query: 1319 DEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL 1378
W + K I + + +ASL I +V+ DAG + R N+ G D + +
Sbjct: 809 VSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQ 868
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT 1438
+ PS KP ++ S + + TI ++ + + K ++
Sbjct: 869 EPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSL 928
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
+ +KT+ S + N + S +KE + VEK + + +
Sbjct: 929 ELYLVKTSDSGTYTCKVSNVAGGVECSANL----FVKE---PATFVEKLEPSQLLKKGDA 981
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFN 1554
+L C G P K+TW+ + +++K + + E+ Y C A N
Sbjct: 982 TQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQN 1041
Query: 1555 DHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE 1614
+ G S +V +++ P T + I+ + + ++ A + G PP E+ W+K+ L
Sbjct: 1042 EAGSDHCSSIVIVKESPYFTKEFKPIEVLKEY--DVMLLAEVAGTPPFEITWFKDNTILR 1099
Query: 1615 NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ ++Y ++ ++I + + + +Y +N G+S + + + PS
Sbjct: 1100 SGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPS 1152
Score = 258 bits (632), Expect = 2e-67
Identities = 263/1191 (22%), Positives = 486/1191 (40%), Gaps = 95/1191 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
++ + P F+ KL+ + G++V EC+V G + WF+ I Q + + N
Sbjct: 3401 DRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSE-N 3459
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
V TL + + P D G +TCVA N AG + L V+ P S + +V
Sbjct: 3460 VCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSV----------- 3508
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
++L G+ TF+ V G+ P + W E+VP E+ ++++
Sbjct: 3509 --EVLPGMSLTFTS------VIRGT-----------PPFKVKWFKGSRELVPGESCNISL 3549
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + + L++ V+ + G Y+ + N G AS L + KEP ++ L
Sbjct: 3550 ED----FVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFV----KEPATFVKRLADF 3601
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK--PKKVKDEGV 802
V G ++L A G P +++W K+ + S T TIL+ ++D
Sbjct: 3602 SVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQ 3661
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
Y+ EN G A+++V EPP FI + + L +V P
Sbjct: 3662 YSCLIENEAGQDICEALVSV-------LEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEI 3714
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
I+WY+ + + + F LVI VD D G+Y C A NS G + A +
Sbjct: 3715 RISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHS-DVGEYSCKADNSVGAVASSAVLV 3773
Query: 923 IDVEKVT--FVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQE 978
I K+ F + L+ +ET G V EC+ S + WY + + + +
Sbjct: 3774 IKARKLPPFFARKLKDVHET-LGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFV 3832
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKD----QETSTMLVVKE-TIPEF--IRKLQ-DFEVKE 1030
+G C + +S L++ E +P F ++ + D + E
Sbjct: 3833 HNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGE 3892
Query: 1031 KDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC- 1089
V + + W +D I+P N Y + L + D G+Y+C
Sbjct: 3893 SGTFKCHV-TGTAPIKITWAKDNREIRPGGN-YKMTLVENTATLTVLKVGKGDAGQYTCY 3950
Query: 1090 ---ILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKAT-FEIELTKGDAL-VRWFKDGS 1144
I +SC+A++ V E PP I +L+ ++ K ++ T +E ++ + V W+KD +
Sbjct: 3951 ASNIAGKDSCSAQLGVQE-PPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDET 4009
Query: 1145 EIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTL 1200
EIQ S+ +++ L++++ ++D+G+Y+CE G++ + L V+EP I
Sbjct: 4010 EIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPI--FR 4067
Query: 1201 RLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
+ P I D +L E+ V+WYK K + +K+ ++S+ ++ I
Sbjct: 4068 KKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVD 4127
Query: 1260 EDDQCEYTC-VLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
D EY C D S T + ++ PP+ V + G +V L + +
Sbjct: 4128 AADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPIS 4187
Query: 1319 DEWIVN-SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
W + +I+++ + S A+L +VE +AG Y +++N+ G + +++
Sbjct: 4188 VVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV 4247
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKT 1436
L+ + KP +++ + + C E G + + + +E+ + + K
Sbjct: 4248 LEPATIVEKPESIKVTTG--DTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKV 4305
Query: 1437 Q-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N+ + S + N V + + + + P+ + LK
Sbjct: 4306 SGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQV-----SDRTVPPSFTRKLKETNGLS 4360
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCI 1551
+ + C G P V+W+ +G ++ + + +N Y CI
Sbjct: 4361 GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCI 4420
Query: 1552 AFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGN 1611
A N G E S + +++ P + D G T++++G PP V W+K +
Sbjct: 4421 ATNMAGSDECSAPLTVREPPSF-VQKPD-PMDVLTGTNVTFTSIVKGTPPFSVSWFKGSS 4478
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+L N++ ++ + + + ++ S S +YT SN AG +S L +
Sbjct: 4479 ELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYI 4529
Score = 257 bits (629), Expect = 4e-67
Identities = 259/1070 (24%), Positives = 450/1070 (42%), Gaps = 66/1070 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PP+F+++ K G + L CRL + W G + EN+ + ++
Sbjct: 2838 LPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDHENLQTSFVDNV--- 2894
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+ LKI G Y+ A N G AS L + +K P I+P+ S+ V GES
Sbjct: 2895 -ATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPV-SIDVIAGES 2952
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
V G ITW K+NK ++ G+T + ILK K D G YT +A
Sbjct: 2953 ADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGK-GDSGQYTCQAT 3011
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWY 867
N G SA ++V+ EPP F+ + + V ++G +I+L +++ +P ++W+
Sbjct: 3012 NDVGKDMCSAQLSVK-------EPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWF 3064
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
RN+ + S +F ++ L+ N S DSGDY C A N G +S +T+
Sbjct: 3065 RNDSELHESWKYNMSFI-NSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPP 3123
Query: 928 VTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
V K +G VIL+C+ S T W ++K++ +I +
Sbjct: 3124 VFTQK--PSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTNLH 3181
Query: 986 XXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS 1042
DVG C ++ +T + V + P F++KL D D L +
Sbjct: 3182 ILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEG 3241
Query: 1043 -ETADVVWERD-GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----C 1096
+ VVW +D GE+I+ +N +I L + + + G+Y C +++++ C
Sbjct: 3242 FQPISVVWLKDRGEVIRESENT-RISFIDNIATLQLGSPEASNSGKYICQIKNDAGMREC 3300
Query: 1097 TAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLT 1155
+A +TV+E P II + + V GN E +T L +WFKDG E+ + +T
Sbjct: 3301 SAVLTVLE-PARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHIT 3359
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRL--PEFILVPANTD 1213
K LKI ++ D G YS EV NS + TV S++ + R+ P FI + +
Sbjct: 3360 FINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTV---SVHVSDRIVPPSFIRKLKDVN 3416
Query: 1214 AYLTVEIPDE-------TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
A L + E + V W++ + I K TL + D Y
Sbjct: 3417 AILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIY 3476
Query: 1267 TCVLLDAKSTTKLK-VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS 1325
TCV + + + V V+ PP + G +T + P +W S
Sbjct: 3477 TCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGS 3536
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
+ + + S++ L + +V+ ++G Y + N+ G A ++ + + +
Sbjct: 3537 RELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVK 3596
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQTSIQNLK 1444
+ +++ S + E TG I + ++ + I +E S+ +T+ T ++ L+
Sbjct: 3597 RLADFSVETGSPIVL--EATYTGTPPISVSWIKDEYLISQSERCSI-TMTEKSTILEILE 3653
Query: 1445 -TNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTC 1503
T Y + + D E + ++ P +PL+++ E L C
Sbjct: 3654 STIEDYAQYSCLIENEAGQDICEAL-------VSVLEPPYFIEPLEHVEAVIGEPATLQC 3706
Query: 1504 IFGGVPQPKVTWYRDGKKLKTA---KATYENR-XXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
G P+ +++WY++ KL++A K ++N Y C A N G V
Sbjct: 3707 KVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAV 3766
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHK-VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+S V+ I+ + + +K H+ +G I G P +V WYK+G L++D
Sbjct: 3767 ASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDAN 3826
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT--SSVEVTLKVYDKP 1666
+ + ++I + +SH +Y ASN GT SS ++ L ++ P
Sbjct: 3827 LQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVP 3876
Score = 251 bits (615), Expect = 2e-65
Identities = 252/1068 (23%), Positives = 432/1068 (40%), Gaps = 60/1068 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P +K V G LEC++ PE + W G+ + + + + +
Sbjct: 2368 PAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKI---- 2423
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
S L+I +V++ GTYT N G++S V+ + + PP LK+ G S
Sbjct: 2424 SSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDV-SDRAVPPSFTRRLKNTGGVLGASC 2482
Query: 753 ILSAQVVGNPRPTITWC-KNNKPVKALPTKSDGDTHSITI-LKPKKVKDEGVYTLKAENS 810
IL +V G+ ++ W + K V ++ + T+ L D G YT A N
Sbjct: 2483 ILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANV 2542
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G E AV+TV+EP P F+ + + V + + + P + W+R
Sbjct: 2543 AGSDECRAVLTVQEP-------PSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGA 2595
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
+ + F+ EL + N+D SG+Y CV SN+AG++S R+ + E F
Sbjct: 2596 RELVKGDRCNIYFEDTVAELELFNIDIS-QSGEYTCVVSNNAGQASCTTRLFVK-EPAAF 2653
Query: 931 VKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+K L + E GK++ILE + T +S W + I+ + I+ +
Sbjct: 2654 LKRLS-DHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILN 2712
Query: 989 XXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI-NSET 1044
D G C ++++ + LV P F+ +L+ E D L+ ++ +
Sbjct: 2713 STKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPE 2772
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV- 1103
V W + ++P +Y ++ L +++D GEY+C + TA V
Sbjct: 2773 ITVSWYKGDTKLRPTP-EYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVF 2831
Query: 1104 -----ELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTID 1157
+LPP +L++ + G T L + V W++DG ++ ++Q +
Sbjct: 2832 RIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDHENLQTSFV 2891
Query: 1158 GKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSIN--FTLRLPEFILVPAN 1211
LKI DL +G+YSC +G + +A LT EP + F ++ P I V A
Sbjct: 2892 DNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIK-PVSIDVIAG 2950
Query: 1212 TDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
A + + + +TW K I +T+ L I K + D +YTC
Sbjct: 2951 ESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQA 3010
Query: 1271 LD--AKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVN-SK 1326
+ K ++ V E PPK V ++ K+G + L P+ W N S+
Sbjct: 3011 TNDVGKDMCSAQLSVKE-PPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSE 3069
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
+ + K+ I+S A LTI + D+G Y N G A +T+ P K
Sbjct: 3070 LHESWKYNMSFINSV-ALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQK 3128
Query: 1387 PNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTN 1446
P+ + S I E T +++ Q ++ ++ T I NL+ +
Sbjct: 3129 PSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTNLHILNLEAS 3188
Query: 1447 SSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG 1506
+ A NEV SD + +K + P K L + +T + +EL I
Sbjct: 3189 DVGEYHCKATNEVG-SDTCSCSVKFK-------EPPRFVKKLSDTSTLIGDAVELRAIVE 3240
Query: 1507 GVPQPKVTWYRD-GKKLKTAKAT----YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G V W +D G+ ++ ++ T +N Y C ND G E
Sbjct: 3241 GFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMREC 3300
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
S V+ + + I E + G+ + + V+ G P W+K+G +L D +++I
Sbjct: 3301 SAVLTVLEPARIIEKPEPMTV--TTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHI 3358
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
T K + ++I + S Y+ E N+ G S+ V++ V D+ P
Sbjct: 3359 TFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPP 3406
Score = 251 bits (614), Expect = 2e-65
Identities = 271/1159 (23%), Positives = 474/1159 (40%), Gaps = 79/1159 (6%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ E PPTF +PK+ G C + P + W G + P N ++ +
Sbjct: 210 VTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAEN 269
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
H +L+++N+ G Y+ A N+ G A + I + + +EP++S I
Sbjct: 270 KH----ILELSNLTIQDRGVYSCKASNKFG-ADICQAELIIIDKPHFIKELEPVQSAI-- 322
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSITILKP-KKVKDEGVYTL 805
+ V L QV + + T+TW K+ + + K + T+ P K+KD G Y
Sbjct: 323 -NKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVC 381
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSI 864
A N G + SA +TV EPP F+ + + G + +L ++ +PV +
Sbjct: 382 TASNEAGSSSCSATVTVR-------EPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQV 434
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
TW++NN+ +S S T+ F L IT+V E DSG Y C A N G S + I
Sbjct: 435 TWFKNNKELSESNTVRMYFVNSEAILDITDVKVE-DSGSYSCEAVNDVGSDSCSTEIVIK 493
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXX 982
E +F+K L+ + + G +L+C+ S T W+ +KK+I + +
Sbjct: 494 -EPPSFIKTLEPA-DIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLV 551
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTML--VVKETIPEFIRKLQDFEVKEKDVAILEV 1038
DVG +C+V ++ + M ++KE P F++K+ D L+
Sbjct: 552 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEP-PTFVKKVDDLIALGGQTVTLQA 610
Query: 1039 EI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES-- 1095
+ SE V W + E+I+ + K + L I + + G+Y+C+ +E+
Sbjct: 611 AVRGSEPISVTWMKGQEVIR-EDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS 669
Query: 1096 -CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQ 1153
+ +V+ P +II R + +V G+ AT E + L +W+KDG + S +
Sbjct: 670 QTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYR 729
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEY----SCEVGNSKCTAILTVEEPSIN--FTLRLPEFIL 1207
++ +LK Y +L D+G+Y S EVG+S C TV + I FT L
Sbjct: 730 ISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDS 789
Query: 1208 VPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
V N L +I + V+W+K I ++++ + +L I + +D +
Sbjct: 790 V-VNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNF 848
Query: 1267 TCVLLDA-KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS 1325
TC ++ S +V+ PP V + GS V L +Q W +
Sbjct: 849 TCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGN 908
Query: 1326 KII---KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
K + C TK +++S SL + V+ +D+G Y ++ N G + N+ + + +
Sbjct: 909 KELVSGGSCYITKEALES---SLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPAT 965
Query: 1383 PPGK---PNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQT 1438
K +L+ ++ C + TG I I + +EI + + + T
Sbjct: 966 FVEKLEPSQLLKKGDATQLAC----KVTGTPPIKITWFANDREIKESSKHRMSFVESTAV 1021
Query: 1439 -SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE 1497
+ ++ S + A NE S ++KE SP K K I
Sbjct: 1022 LRLTDVGIEDSGEYMCEAQNEAGSDHCSSIV----IVKE----SPYFTKEFKPIEVLKEY 1073
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATY--ENRXXXXXXXXXXXXXXXYKCIAF 1553
D+ L G P ++TW++D L++ + T+ ++ Y+C
Sbjct: 1074 DVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVT 1133
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKL 1613
N+ G S V +++ P E G A ++G P V W K+ +++
Sbjct: 1134 NEVGSSICSARVTLREPPSFIKKIESTSSLR--GGTAAFQATLKGSLPITVTWLKDSDEI 1191
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
D +T + + + + ++ H KY +A N AG L V + + E V
Sbjct: 1192 TEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAV 1251
Query: 1674 IMREISRESVTIEWKPPLDDGGLELT-KYAIEKHEPDNNRWIKVADVDR-DVETYCIQKL 1731
+ + T++ K G E+T K+ + E K++ D + +
Sbjct: 1252 SIDVTQGDPATLQVK---FSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEK 1308
Query: 1732 NENCEYMFRVIAQNPVGFS 1750
++ EY F V QN VG S
Sbjct: 1309 KDSGEYTFEV--QNDVGRS 1325
Score = 244 bits (597), Expect = 3e-63
Identities = 242/1086 (22%), Positives = 448/1086 (41%), Gaps = 65/1086 (5%)
Query: 633 PPTFSKKPK-AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PP F KK + ++ V + EC++ PE + W EI ++ +
Sbjct: 3969 PPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSV--- 4025
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+VL++ N+ G YT A N G AS LK+K EPP + + +G
Sbjct: 4026 -AVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVK----EPPIFRKKPHPIETLKGAD 4080
Query: 752 VILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
V L ++ G P ++W K+ + + K S+ SI IL D G Y KA
Sbjct: 4081 VHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAA-DIGEYQCKAT 4139
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
N G I ++ P P F+ + +I+ ++L + S+ W++
Sbjct: 4140 NDVGSDTCVGSIALKAP-------PRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFK 4192
Query: 869 NN-EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ EI+ S+ I ++ ENI + + ++G Y C N AG A +++ +E
Sbjct: 4193 DKGEIVRESDNIWISYS-ENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV-LEP 4250
Query: 928 VTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
T V+ +S + G T LEC + T +STKW+ + KE++ + +I +
Sbjct: 4251 ATIVEK-PESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLK 4309
Query: 986 XXXXXXXDVGVIKCIV-----KDQETSTMLVVKETIP-EFIRKLQDFEVKEKDVAILEVE 1039
D GV V KD T+++ V T+P F RKL++ ++E +
Sbjct: 4310 IINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECK 4369
Query: 1040 I-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----E 1094
+ S V W +G I + KY + L + D G+Y+CI + +
Sbjct: 4370 VYGSPPISVSWFHEGNEISSGR-KYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSD 4428
Query: 1095 SCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA--LVRWFKDGSEIQFSNHI 1152
C+A +TV E PP + + V G TF + KG V WFK SE+ +
Sbjct: 4429 ECSAPLTVRE-PPSFVQKPDPMDVLTGTNVTFT-SIVKGTPPFSVSWFKGSSELVPGDRC 4486
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFILV 1208
++++ +L+++D D +GEY+C E G + CT L ++ P+ F RL ++ +
Sbjct: 4487 NVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPA-KFVKRLNDYSIE 4545
Query: 1209 PANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC 1268
+ VTW K + +++ + + K L I T +D +Y C
Sbjct: 4546 KGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSPILEIPSSTVEDAGQYNC 4605
Query: 1269 VLLDA--KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
+ +A K + ++ ++E PP V ++ G +L P+ W
Sbjct: 4606 YIENASGKDSCSAQILILE-PPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDT 4664
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
++ K + A+L +V+ D+G Y + EN+ G +T+ ++ PP
Sbjct: 4665 KLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSF 4724
Query: 1387 PNILEIDSSSIN--ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLK 1444
L ++ + +D + + + + + + + + + T T + K
Sbjct: 4725 SRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTAT-LNIFK 4783
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI 1504
T+ S + I AS + ++ E K P + L + E + C
Sbjct: 4784 TDRSLAGQYSCTATNPIGSASSSARL--ILTEGK-NPPFFDIRLAPVDAVVGESADFECH 4840
Query: 1505 FGGVPQPKVTWYRDGKKLKTA---KATY-ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
G KV+W +D +++++ + +Y EN Y C A N+ G+
Sbjct: 4841 VTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDS 4900
Query: 1561 TSCVVGIQQKPVITISNEDIKQ--KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + I+++ + + + + + G+ + + + G P V WYKN +++
Sbjct: 4901 CTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSN 4960
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
IT K T V+++++ + + YT + SN AG++ ++ V +P KP PV + +
Sbjct: 4961 CEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSI-VIKEPKKP--PVFDQHL 5017
Query: 1679 SRESVT 1684
+ +V+
Sbjct: 5018 TPVTVS 5023
Score = 243 bits (595), Expect = 5e-63
Identities = 244/1062 (22%), Positives = 433/1062 (40%), Gaps = 60/1062 (5%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L+C++ ++W G+EI + +A + L+I V G +T A
Sbjct: 797 LDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGT----ASLEIIRVDMNDAGNFTCRA 852
Query: 713 VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN 772
N G L ++ EPP + S V G +V L + G+ TI W K N
Sbjct: 853 TNSVGSKDSSGALIVQ----EPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGN 908
Query: 773 KPVKALPTK--SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENA 830
K + + + + S L K D G YT K N G E SA + V+EP
Sbjct: 909 KELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPAT--- 965
Query: 831 EPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE 889
F+ + + + +KG +L +VT P ITW+ N+ I S +F
Sbjct: 966 ----FVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAV 1021
Query: 890 LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVIL- 948
L +T+V E DSG+Y C A N AG S H + + I E F K + +E ++L
Sbjct: 1022 LRLTDVGIE-DSGEYMCEAQNEAG-SDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLA 1079
Query: 949 ECQTSHTVSTKWYHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETS 1007
E + W+ + + SG ++ IQ+ D G +C V ++ S
Sbjct: 1080 EVAGTPPFEITWFKDNTILRSGRKYKTFIQD-HLVSLQILKFVAADAGEYQCRVTNEVGS 1138
Query: 1008 TMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKN-K 1062
++ + T+ P FI+K++ A + + S V W +D + I N +
Sbjct: 1139 SICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIR 1198
Query: 1063 YDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKV 1118
FE ++ LY+ V +G+Y C ++++ C+A ++V E P I + V
Sbjct: 1199 MTFEN--NVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKE-PATITEEAVSIDV 1255
Query: 1119 NKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
+G+ AT +++ + + +WFKDG E+ + ++++ LKI + D+GEY+
Sbjct: 1256 TQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYT 1315
Query: 1178 CEV----GNSKCTAILTVEEPSI--NFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYK 1231
EV G S C A + V + I +FT +L + + + + + + W+K
Sbjct: 1316 FEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFK 1375
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKI 1290
I +EK+ L I + D YTC + + + V+ PP
Sbjct: 1376 DDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYF 1435
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
V+ + + + V L +W ++K + D S SL +
Sbjct: 1436 VEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAA 1495
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNS 1410
+ TD+G Y +L N+ G A + + + + P KP+ + + + + + E + TG
Sbjct: 1496 KATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTF-ECQITGTP 1554
Query: 1411 TI-IYYVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASETT 1468
I + + ++ EI + + I T I + +S + A N+ + S
Sbjct: 1555 KIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIEL 1614
Query: 1469 EYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA- 1527
+ +KE PT + LK + D+EL C G P +VTW ++ ++++++K
Sbjct: 1615 K----VKEP----PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKY 1666
Query: 1528 TYENRXXXXXXXXXX---XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH 1584
T +R Y+CI N+ G S V +++ P E+
Sbjct: 1667 TLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVL 1726
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K + T + G PP + W K+ L+ D I+ + + ++I+ + HS +YT
Sbjct: 1727 KSSATFQST--VAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYT 1784
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+A N +G L V + E + ++ +T+E
Sbjct: 1785 CQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLE 1826
Score = 242 bits (592), Expect = 1e-62
Identities = 273/1209 (22%), Positives = 484/1209 (40%), Gaps = 96/1209 (7%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
VEK + + + EC V G P ++ W + I PS+ F M +++ NVA+ I+
Sbjct: 1809 VEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFEN-NVASFRIQS 1867
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGI 632
V +D+G +T +N F SS+ + + + + I
Sbjct: 1868 VMKQDSGQYTFKVEN--DFGSSSCDAYLRV-------------------------LDQNI 1900
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F+KK GS I +EC++ W G+EI + S H
Sbjct: 1901 PPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEI----STSAKYRLVCHERS 1956
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ-VIEPLKSMIVRQGES 751
L++ N++ YT N G+ + +L +K EPP +++P + + +
Sbjct: 1957 VSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVK----EPPSFLVKPGRQQAIPDS-T 2011
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAEN 809
V A + G P I W K++ + + P G S + L V G YT N
Sbjct: 2012 VEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 2071
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWYR 868
G + ++ V EPP F+ + + + + G + +L ++ +P + W+R
Sbjct: 2072 DVGSDSCTTMLLV-------TEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFR 2124
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
N + S+ F + + N+ +E DSGD+ C A N AG +S +V + V
Sbjct: 2125 NEHELPASDKYRMTFIDSVAVIQMNNLSTE-DSGDFICEAQNPAGSTSCSTKVIVKEPPV 2183
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
ET + V LEC+ S T WY +K+++ +I +
Sbjct: 2184 --FSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHI 2241
Query: 987 XXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-S 1042
D+G C +++ +T V + P F+ KL V + A L+ I +
Sbjct: 2242 LNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGA 2301
Query: 1043 ETADVVWERDGE-IIKPKKN-KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE- 1099
+ V W ++ E +I+ +N + F + ++ L + G+Y C ++++ E
Sbjct: 2302 QPIFVQWLKEKEEVIRESENIRITFVE--NVATLQFAKAEPANAGKYICQIKNDGGMREN 2359
Query: 1100 -VTVVELPPEIITRLQN-QKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTI 1156
T++ L P +I V G T E ++ L V W+KDG + S + +
Sbjct: 2360 MATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSF 2419
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSI--NFTLRLPEFILVPA 1210
K L+I + DAG Y+ +V G S CTA++ V + ++ +FT RL V
Sbjct: 2420 YNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGV-L 2478
Query: 1211 NTDAYLTVEIPDET-LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
L ++ + + V W+ +K+ I K+ TL + D YTCV
Sbjct: 2479 GASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCV 2538
Query: 1270 LLDAKSTTKLK-VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
+ + + + V V+ PP V + G +VT + P W ++ +
Sbjct: 2539 AANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGAREL 2598
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN 1388
K + A L + ++ + +G Y + NN G A + + + + + +
Sbjct: 2599 VKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLS 2658
Query: 1389 ILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNS 1447
++ I E TG I + + + I T+E ++ +T +T I + NS
Sbjct: 2659 DHSVEPGKSIIL--ESTYTGTLPISVTWKKDGFNITTSEKCNI--VTTEKTCILEI-LNS 2713
Query: 1448 SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
+ R E++ ++A + + T ++ P L+ + + + L C G
Sbjct: 2714 TKRDAGQYSCEIE-NEAGR--DVCGALVST-LEPPYFVTELEPLEAAVGDSVSLQCQVAG 2769
Query: 1508 VPQPKVTWYRDGKKLKTAKA--TY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
P+ V+WY+ KL+ TY N Y C A N G +
Sbjct: 2770 TPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKT 2829
Query: 1564 VVGIQQK---PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
V IQ++ P +DI+Q VG +T + G P +V WY++G L + +
Sbjct: 2830 VFRIQERQLPPSFARQLKDIEQT--VGLPVTLTCRLNGSAPIQVCWYRDGVLLRDHENLQ 2887
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP---EGPVIMRE 1677
+ + + ++I + SHS +Y+ ASN GT+S L + P PV +
Sbjct: 2888 TSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDV 2947
Query: 1678 ISRESVTIE 1686
I+ ES E
Sbjct: 2948 IAGESADFE 2956
Score = 242 bits (592), Expect = 1e-62
Identities = 271/1208 (22%), Positives = 492/1208 (40%), Gaps = 98/1208 (8%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
+EK P G+ EC V G P WF+ + + + + VA+L I
Sbjct: 3313 IEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFIN-KVASLKIPC 3371
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGI 632
D G ++ KN+ G ++ T +S H S+ V
Sbjct: 3372 AEMSDKGLYSFEVKNSVGKSNCT--------VSVHVSDRIV------------------- 3404
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F +K K G+ ++LECR+ + W G EIV + ++ C
Sbjct: 3405 PPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENV---C 3461
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L ++ ++ G YT VA N G VL + +EPP + S+ V G S+
Sbjct: 3462 T-LNLSLLEPSDTGIYTCVAANVAGSDECSAVLTV----QEPPSFEQTPDSVEVLPGMSL 3516
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAENS 810
++ + G P + W K ++ + + + +T L+ +V+ + G Y+ N
Sbjct: 3517 TFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTND 3576
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G A + + V+EP F+ R + +V+ I L A T P S++W ++
Sbjct: 3577 AGSASCTTHLFVKEPA-------TFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDE 3629
Query: 871 EIISPSE--TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
+IS SE +IT +E++ + ++ D Y C+ N AG+ A V++ +E
Sbjct: 3630 YLISQSERCSITMTEKSTILEILESTIE---DYAQYSCLIENEAGQDICEALVSV-LEPP 3685
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
F++ L+ E G+ L+C+ T + WY ++ ++ +
Sbjct: 3686 YFIEPLE-HVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVI 3744
Query: 987 XXXXXXDVGVIKCIVKDQ----ETSTMLVVK--ETIPEFIRKLQDFEVKEKDVAILEVEI 1040
DVG C + +S +LV+K + P F RKL+D E I
Sbjct: 3745 NKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRI 3804
Query: 1041 N-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N SE V W +DG ++K N ++ L I T G+Y+C + TA
Sbjct: 3805 NGSEPLQVSWYKDGVLLKDDAN-LQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTAS 3863
Query: 1100 ------VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
++ E+PP + + + G TF+ +T G A ++ W KD EI+ +
Sbjct: 3864 SSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVT-GTAPIKITWAKDNREIRPGGN 3922
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRL-PEFI 1206
++T+ L + DAG+Y+C G C+A L V+EP F +L P I
Sbjct: 3923 YKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPP-RFIKKLEPSRI 3981
Query: 1207 LVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
+ Y + V WYK ++ I+++ KF + L + + +D +Y
Sbjct: 3982 VKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDY 4041
Query: 1267 TCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS 1325
TC +A + + V+ PP +G+DV L + Q P + W +
Sbjct: 4042 TCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDK 4101
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
+ ++ K K ++ S+ I V+ D G Y+ + N+ G ++ + P
Sbjct: 4102 RELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVK 4161
Query: 1386 K-PNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISV-KNITKTQTSIQ 1441
K +I + + + E +++++ + + + ++ WIS +NI Q S
Sbjct: 4162 KLSDISTVVGKEVQL-QTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFS-- 4218
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIEL 1501
++ ++ ++ N+ + + T V++ I VEKP ++I + L
Sbjct: 4219 RVEPANAGKYTCQIKNDAGMQECFAT---LSVLEPATI----VEKP-ESIKVTTGDTCTL 4270
Query: 1502 TCIFGGVPQPKVTWYRDGKKLKT---AKATYENRXXXXXXXXXX-XXXXXYKCIAFNDHG 1557
C G P+ W++DGK+L + K ++ N+ Y N G
Sbjct: 4271 ECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVG 4330
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
+ + + + + V +K+ + + G ++ + G PP V W+ GN++ +
Sbjct: 4331 KDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSG 4390
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
++Y T + T + + L+ S S YT A+N AG+ L V + PS + P M
Sbjct: 4391 RKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMD 4450
Query: 1677 EISRESVT 1684
++ +VT
Sbjct: 4451 VLTGTNVT 4458
Score = 240 bits (587), Expect = 4e-62
Identities = 245/1068 (22%), Positives = 429/1068 (40%), Gaps = 65/1068 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F +KP++Q V+ + + L+ + I W +E+ SV +
Sbjct: 1432 PPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTS---- 1487
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE-PLKSMIVRQGES 751
+ L++ K GTY N G A+ L +K EPPQ I+ P +++R G+S
Sbjct: 1488 TSLELFAAKATDSGTYICQLSNDVGTATSKATLFVK----EPPQFIKKPSPVLVLRNGQS 1543
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI--LKPKKVKDEGVYTLKAEN 809
Q+ G P+ ++W + + A+ + + +V++ G Y +A N
Sbjct: 1544 TTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARN 1603
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G A S + V+EP P FI + + V + ++L VT P +TW +N
Sbjct: 1604 DAGTASCSIELKVKEP-------PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKN 1656
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
N I S+ T L IT D D+G+Y+C+ SN G S RV + E +
Sbjct: 1657 NREIRSSKKYTLTDRVSVFNLHITKCDPS-DTGEYQCIVSNEGGSCSCSTRVALK-EPPS 1714
Query: 930 FVKHLQKSYET-EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
F+K ++ + + T S +S W + + + D+ I
Sbjct: 1715 FIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRS 1774
Query: 989 XXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIRKLQDFEVKEKDVAILE-VEINSE 1043
G C K++ L+V+E + + K + +V EKD LE V +
Sbjct: 1775 VDNGHSGRYTCQAKNESGVERCYAFLLVQEPA-QIVEKAKSVDVTEKDPMTLECVVAGTP 1833
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----SCTAE 1099
V W +DG+ I P + + ++ I++ D G+Y+ + ++ SC A
Sbjct: 1834 ELKVKWLKDGKQIVPSRY-FSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAY 1892
Query: 1100 VTVVE--LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTI 1156
+ V++ +PP +L G+ E +++ + +WFKDG EI S +L
Sbjct: 1893 LRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVC 1952
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPEFILVPANT 1212
+ L++ + +L+D Y+C+V G+ C+ ILTV+EP +F ++ +P +T
Sbjct: 1953 HERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPP-SFLVKPGRQQAIPDST 2011
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC-VLL 1271
+ + + W+K + K + + L + +YTC V
Sbjct: 2012 VEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTN 2071
Query: 1272 DAKSTTKLKVEVVEFPPKIVD-YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS-KIIK 1329
D S + + +V PPK V E +K G L P+ W N ++
Sbjct: 2072 DVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPA 2131
Query: 1330 KCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI 1389
K+ IDS A + + + D+G + +N G V + + P P I
Sbjct: 2132 SDKYRMTFIDSV-AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPI 2190
Query: 1390 LE-IDSSSINI-CWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTN 1446
+E + ++ +++ C E T +++Y + Q + ++ I+ KN T I N+ T+
Sbjct: 2191 VETLKNAEVSLEC--ELSGTPPFEVVWYKDKRQLRSSKKYKIASKNF-HTSIHILNVDTS 2247
Query: 1447 SSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG 1506
+ A NEV SD T K + P L ++T E EL
Sbjct: 2248 DIGEYHCKAQNEVG-SDTCVCTVKLK-------EPPRFVSKLNSLTVVAGEPAELQASIE 2299
Query: 1507 GVPQPKVTWYRDGKKL----KTAKATY-ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G V W ++ +++ + + T+ EN Y C ND G E
Sbjct: 2300 GAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMREN 2359
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ + + VI + VG+ + + G P V WYK+G L + +++
Sbjct: 2360 MATLMVLEPAVIVEKAGPMTVT--VGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKF 2417
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
+ K S +RI ++R + YT + N G SS + V D+ P
Sbjct: 2418 SFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPP 2465
Score = 237 bits (580), Expect = 3e-61
Identities = 240/1090 (22%), Positives = 433/1090 (39%), Gaps = 63/1090 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P +KP+ V G+ LEC + PE W G E+ D + + +
Sbjct: 3309 PARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKV---- 3364
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ LKI + +G Y+ N G+++ + + + + PP I LK + G SV
Sbjct: 3365 ASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV-SDRIVPPSFIRKLKDVNAILGASV 3423
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAENS 810
+L +V G+ ++ W ++ + + P + ++ L ++ D G+YT A N
Sbjct: 3424 VLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANV 3483
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G E SAV+TV+EP P F + V ++ + + P + W++ +
Sbjct: 3484 AGSDECSAVLTVQEP-------PSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGS 3536
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
+ P E+ + + EL + V ++SGDY C+ +N AG +S + + E TF
Sbjct: 3537 RELVPGESCNISLEDFVTELELFEVQP-LESGDYSCLVTNDAGSASCTTHLFVK-EPATF 3594
Query: 931 VKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
VK L + E G ++LE + T +S W ++ IS + I +
Sbjct: 3595 VKRLA-DFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILE 3653
Query: 989 XXXXDVGVIKCIVKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SET 1044
D C++++ Q+ LV P FI L+ E + A L+ +++ +
Sbjct: 3654 STIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPE 3713
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----CTAEV 1100
+ W ++ ++ Y + + ++ L I D GEYSC D S ++ V
Sbjct: 3714 IRISWYKEHTKLRSAP-AYKMQFKNNVASLVINKVDHSDVGEYSC-KADNSVGAVASSAV 3771
Query: 1101 TVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTI 1156
V++ LPP +L++ G FE + + L V W+KDG ++ ++Q +
Sbjct: 3772 LVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSF 3831
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA------ILTVEEPSINFTLRLPEFILVPA 1210
L+I D G+Y+C N TA IL+ E F L+ L
Sbjct: 3832 VHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALG 3891
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
+ + + +TW K I + + TL + K + D +YTC
Sbjct: 3892 ESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYA 3951
Query: 1271 LDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLL-VDYQAFPQPNDEWIVNSKII 1328
+ ++ V+ PP+ + RI + + T P+ W + I
Sbjct: 3952 SNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEI 4011
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN 1388
++ + S A L + + D+G Y N G A ++ + + P KP+
Sbjct: 4012 QESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPH 4071
Query: 1389 ILE-IDSSSINI-CWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTN 1446
+E + + +++ C E + T + +Y + + ++ + T I N+
Sbjct: 4072 PIETLKGADVHLEC--ELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAA 4129
Query: 1447 SSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG 1506
++ A N+V S+T +K P K L +I+T ++++L
Sbjct: 4130 DIGEYQCKATNDV----GSDTCVGSIALKAP----PRFVKKLSDISTVVGKEVQLQTTIE 4181
Query: 1507 GVPQPKVTWYRD-GKKLKTAKATY----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G V W++D G+ ++ + + EN Y C ND G E
Sbjct: 4182 GAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQEC 4241
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ + + I E IK GD + + G P W+K+G +L +D +Y I
Sbjct: 4242 FATLSVLEPATIVEKPESIKVT--TGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKI 4299
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE---I 1678
+ K S ++I + S S Y+ E N G S +L+V D+ P ++E +
Sbjct: 4300 SFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL 4359
Query: 1679 SRESVTIEWK 1688
S SV +E K
Sbjct: 4360 SGSSVVMECK 4369
Score = 235 bits (574), Expect = 2e-60
Identities = 255/1071 (23%), Positives = 432/1071 (40%), Gaps = 75/1071 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F KK + S + + P I WL + + D+N+ ++ +
Sbjct: 1712 PPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSV---- 1767
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L+I +V G YT A N G L ++ EP Q++E KS+ V + + +
Sbjct: 1768 ATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQ----EPAQIVEKAKSVDVTEKDPM 1823
Query: 753 ILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L V G P + W K+ K P + + + S I K +D G YT K EN
Sbjct: 1824 TLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMK-QDSGQYTFKVEN 1882
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G + A + V ++N PP F + ++ +I + +V+ + S W+++
Sbjct: 1883 DFGSSSCDAYLRV---LDQNI-PPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKD 1938
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ IS S ++ L + N++ E D+ +Y C SN AG + +T+
Sbjct: 1939 GKEISTSAKYRLVCHERSVSLEVNNLELE-DTANYTCKVSNVAGDDACSGILTVKEPPSF 1997
Query: 930 FVKHLQKSY---ETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
VK ++ T E K ++ + + KW+ + E+ I EG
Sbjct: 1998 LVKPGRQQAIPDSTVEFKAIL---KGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNL 2054
Query: 987 XXXXXXDVGVIKCIVKDQETS----TMLVVKETIPEFIRKLQDFE-VKEKDVAILEVEI- 1040
G C V + S TML+V E P+F++KL+ + VK D + LE +I
Sbjct: 2055 YSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEP-PKFVKKLEASKIVKAGDSSRLECKIA 2113
Query: 1041 NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----SC 1096
S VVW R+ + P +KY + + + N S D G++ C ++ SC
Sbjct: 2114 GSPEIRVVWFRNEHEL-PASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSC 2172
Query: 1097 TAEVTVVELP-----PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSN 1150
+ +V V E P P I+ L+N +V+ E EL+ V W+KD +++ S
Sbjct: 2173 STKVIVKEPPVFSSFPPIVETLKNAEVS------LECELSGTPPFEVVWYKDKRQLRSSK 2226
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFI 1206
++ + I + D D GEY C EVG+ C + ++EP F +L
Sbjct: 2227 KYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPP-RFVSKLNSLT 2285
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQC 1264
+V A A L I + + V W K+K VI ++E + TL K +
Sbjct: 2286 VV-AGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAG 2344
Query: 1265 EYTCVLL-DAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
+Y C + D + +V P IV+ + G TL P+ + EW
Sbjct: 2345 KYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYK 2404
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
+ K++ + K S +K +SL I VE DAG Y +++NN G + V + D+ P
Sbjct: 2405 DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVP 2464
Query: 1384 PGKPNILEIDSSSINI-CWDEPENTGNSTIIYYVVEYQEIDTTEWIS-VKNITKTQTSIQ 1441
P L+ + C E + G+S I V + E T+ +S K T ++
Sbjct: 2465 PSFTRRLKNTGGVLGASCILECKVAGSSPI--SVAWFHE--KTKIVSGAKYQTTFSDNVC 2520
Query: 1442 NLKTNS--SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDI 1499
L+ NS S Y +++ + E T + P+ K + + P +++
Sbjct: 2521 TLQLNSLDSSDMGNYTCVAANVAGSDECRAVL-----TVQEPPSFVKEPEPLEVLPGKNV 2575
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENR-XXXXXXXXXXXXXXXYKCIAFND 1555
T + G P KV W+R ++L +E+ Y C+ N+
Sbjct: 2576 TFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNN 2635
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G + SC + K + G ++ + G P V W K+G +
Sbjct: 2636 AG--QASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITT 2693
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
++ NI T EKT ++ I + + +Y+ E N AG + + P
Sbjct: 2694 SEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPP 2744
Score = 232 bits (568), Expect = 9e-60
Identities = 254/1091 (23%), Positives = 436/1091 (39%), Gaps = 71/1091 (6%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
IPP+F+KK K +GS I LEC + I W +EI E + H
Sbjct: 1338 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFS----FHDN 1393
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+ L+I+ ++ GTYT A N+ G L + KEPP +E +S V
Sbjct: 1394 TAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTV----KEPPYFVEKPQSQDVNPNTR 1449
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKS--DGDTHSITILKPKKVKDEGVYTLKAEN 809
V L A V G TI W K+NK + + +S DT + L K D G Y + N
Sbjct: 1450 VQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSN 1509
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWYR 868
G A + A + V+ EPP FI + + V G + ++T P ++WY
Sbjct: 1510 DVGTATSKATLFVK-------EPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYL 1562
Query: 869 N-NEIISPSETITQNFDG-ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+ NEI + + DG ++ V+ +SG Y C A N AG +S + + E
Sbjct: 1563 DGNEITAIQKHGISFIDGLATFQISGARVE---NSGTYVCEARNDAGTASCSIELKVK-E 1618
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXX 984
TF++ L K E + V LEC+ + T W N +EI +
Sbjct: 1619 PPTFIREL-KPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNL 1677
Query: 985 XXXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G +CIV ++ ST + +KE P FI+K+++ K A + +
Sbjct: 1678 HITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEP-PSFIKKIENTTTVLKSSATFQSTV 1736
Query: 1041 -NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES---- 1095
S + W +D +I+ N Y + L IR+ G Y+C ++ES
Sbjct: 1737 AGSPPISITWLKDDQILDEDDNVY-ISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVER 1795
Query: 1096 CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQL 1154
C A + V E P +I+ + ++ V + + T E + L V+W KDG +I S + +
Sbjct: 1796 CYAFLLVQE-PAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSM 1854
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSI--NFTLRLPEFILV 1208
+ + +I D+G+Y+ +V G+S C A L V + +I +FT +L + V
Sbjct: 1855 SFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKV 1914
Query: 1209 PANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ ++ ++ + W+K I + K+ L+ + +L + +D YT
Sbjct: 1915 -LGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYT 1973
Query: 1268 CVLLDAKSTTKLK-VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
C + + + V+ PP + + S V + P +W +
Sbjct: 1974 CKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDV 2033
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
+ ++ ++ L + V+ + G Y + N+ G + + + P K
Sbjct: 2034 ELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKK 2093
Query: 1387 ---PNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-SIQN 1442
I++ SS C + + ++++ E+ E+ ++ + I + N
Sbjct: 2094 LEASKIVKAGDSSRLEC--KIAGSPEIRVVWFRNEH-ELPASDKYRMTFIDSVAVIQMNN 2150
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
L T S F A N + S ++KE + S P+ + T N ++ L
Sbjct: 2151 LSTEDSGDFICEAQNPAGSTSCSTKV----IVKEPPVFSSF--PPI--VETLKNAEVSLE 2202
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
C G P +V WY+D ++L+++K A+ Y C A N+ G
Sbjct: 2203 CELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGS 2262
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
C V +++ P + G+ + A IEG P V W K ++ + E
Sbjct: 2263 DTCVCTVKLKEPPRFVSKLNSLTV--VAGEPAELQASIEGAQPIFVQWLKEKEEVIRESE 2320
Query: 1619 -YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
IT E + ++ + + +++ KY + N G TL V + E M
Sbjct: 2321 NIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTV 2380
Query: 1678 ISRESVTIEWK 1688
E+ T+E K
Sbjct: 2381 TVGETCTLECK 2391
Score = 227 bits (556), Expect = 3e-58
Identities = 263/1190 (22%), Positives = 478/1190 (40%), Gaps = 98/1190 (8%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F++K+ + G T F+ ++G +TW + + I + +M +++ NVA+L
Sbjct: 1151 PSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFEN-NVASLY 1209
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
+ + + G + C AKN AG + L V+ P + +++ D+
Sbjct: 1210 LSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSI-------------DVT 1256
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+G P T L+ + E W G+E+ +++ +
Sbjct: 1257 QGDPAT-----------------LQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTV- 1298
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S+LKI + +K G YT N G +S + + PP + LK M +G
Sbjct: 1299 ---SILKIISTEKKDSGEYTFEVQNDVGRSSCKARINV-LDLIIPPSFTKKLKKMDSIKG 1354
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTK--SDGDTHSITILKPKKVKDEGVYTLKA 807
+ L V G+ +I W K+++ + A S D + + + D G YT A
Sbjct: 1355 SFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSA 1414
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
N G + S +TV+ EPP F+ + Q V ++L A V +I W+
Sbjct: 1415 TNKAGHNQCSGHLTVK-------EPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWF 1467
Query: 868 RNNEII--SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
++N+ + + ++ ++ ++EL DSG Y C SN G ++ A + +
Sbjct: 1468 KDNKELHSGAARSVWKDDTSTSLELFAAKA---TDSGTYICQLSNDVGTATSKATLFVK- 1523
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXX 983
E F+K G++ ECQ + T + WY + EI+ + I
Sbjct: 1524 EPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLAT 1583
Query: 984 XXXXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVE 1039
+ G C ++ S L VKE P FIR+L+ EV + LE E
Sbjct: 1584 FQISGARVENSGTYVCEARNDAGTASCSIELKVKEP-PTFIRELKPVEVVKYSDVELECE 1642
Query: 1040 I-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE---- 1094
+ + +V W ++ I+ K KY R + L+I D GEY CI+ +E
Sbjct: 1643 VTGTPPFEVTWLKNNREIRSSK-KYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSC 1701
Query: 1095 SCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQ 1153
SC+ V + E PP I +++N + ATF+ + + + W KD + +++
Sbjct: 1702 SCSTRVALKE-PPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVY 1760
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
++ L+I D +G Y+C E G +C A L V+EP+ + +
Sbjct: 1761 ISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPA-QIVEKAKSVDVTE 1819
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC- 1268
+ V L V W K I + F++ + + I+ + D +YT
Sbjct: 1820 KDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFK 1879
Query: 1269 VLLDAKSTT---KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS 1325
V D S++ L+V PP + GS + + + +W +
Sbjct: 1880 VENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDG 1939
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
K I + +S SL + +E D Y ++ N G +T+ + PS
Sbjct: 1940 KEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLV 1999
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLK 1444
KP + S + T I ++ + + + + +I ++ T + ++ ++
Sbjct: 2000 KPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGST-SFLNLYSVD 2058
Query: 1445 TNSSYRFRAYAVNEVDISDASET----TEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+ + ++ + N+V SD+ T TE K +K K+++ + K +
Sbjct: 2059 ASKTGQYTCHVTNDVG-SDSCTTMLLVTEPPKFVK--KLEASKIVK--------AGDSSR 2107
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTA---KATY-ENRXXXXXXXXXXXXXXXYKCIAFNDH 1556
L C G P+ +V W+R+ +L + + T+ ++ + C A N
Sbjct: 2108 LECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPA 2167
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
G S V +++ PV + S I + K E + + G PP EV+WYK+ +L +
Sbjct: 2168 GSTSCSTKVIVKEPPVFS-SFPPIVETLK-NAEVSLECELSGTPPFEVVWYKDKRQLRSS 2225
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
K+Y I +K + I I + S +Y +A N G+ + T+K+ + P
Sbjct: 2226 KKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPP 2275
Score = 223 bits (546), Expect = 4e-57
Identities = 224/984 (22%), Positives = 400/984 (40%), Gaps = 67/984 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P T +KP++ V G LEC + PE W G+E+ D ++ + +
Sbjct: 4250 PATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKV---- 4305
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
S LKI NV G Y+ N G+ S L++ + PP LK G SV
Sbjct: 4306 SGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQV-SDRTVPPSFTRKLKETNGLSGSSV 4364
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
++ +V G+P +++W + + T +T ++T+ ++ D G YT A N
Sbjct: 4365 VMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEE-SDSGDYTCIATN 4423
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G E SA +TV EP P F+ + + V + + V P S++W++
Sbjct: 4424 MAGSDECSAPLTVREP-------PSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKG 4476
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + P + + + EL + +VD+ SG+Y C+ SN AGK+S + I
Sbjct: 4477 SSELVPGDRCNVSLEDSVAELELFDVDTS-QSGEYTCIVSNEAGKASCTTHLYIKAP-AK 4534
Query: 930 FVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
FVK L Y E+GK +ILE + T +S W N ++ I +
Sbjct: 4535 FVKRLN-DYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSPILEIP 4593
Query: 988 XXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI-NS 1042
D G C +++ S +++ E P F+++L+ +V D A L+ ++ +
Sbjct: 4594 SSTVEDAGQYNCYIENASGKDSCSAQILILEP-PYFVKQLEPVKVSVGDSASLQCQLAGT 4652
Query: 1043 ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----SCTA 1098
V W + ++P Y R ++ L ++D GEY C + S +
Sbjct: 4653 PEIGVSWYKGDTKLRPTTT-YKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSAST 4711
Query: 1099 EVTVVE--LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLT 1155
+TV E LPP +L++ + G F+ ++ + + V W+KDG ++ S ++Q +
Sbjct: 4712 FLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTS 4771
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGN------SKCTAILTVEEPSINFTLRLPEFILVP 1209
L I+ D AG+YSC N S ILT + F +RL V
Sbjct: 4772 FLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV 4831
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ + + + V+W K I K+ + L + K + D +YTC
Sbjct: 4832 GESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCY 4891
Query: 1270 LLDA----KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQP-NDEWIVN 1324
++ T +L ++ PP E + + L A QP W N
Sbjct: 4892 AVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKN 4951
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+ I+ + + + + + L ++K DAG+Y ++ N+ G A ++ I + PP
Sbjct: 4952 NIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPP 5011
Query: 1385 G-KPNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
++ + S G+ I I ++ +EI ++ S + T++
Sbjct: 5012 VFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFS--FASGTAVLE 5069
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN----ITTEPN-- 1496
L+ + Y +++ S+TT+ IK+ +P +K + +EP
Sbjct: 5070 LRDVAKADSGDYVCKASNVA-GSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSI 5128
Query: 1497 ---EDIELTCI--FGGVPQPKVTWYRDG-KKLKTAKATYENRXXXXXXX----XXXXXXX 1546
E T I GG P P V W + ++L + ++
Sbjct: 5129 RVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSG 5188
Query: 1547 XYKCIAFNDHGEVETSCVVGIQQK 1570
Y+C+AFN+HGE+E++ + + ++
Sbjct: 5189 LYRCVAFNEHGEIESNVNLQVDER 5212
Score = 220 bits (538), Expect = 4e-56
Identities = 238/1072 (22%), Positives = 437/1072 (40%), Gaps = 75/1072 (6%)
Query: 633 PPTFSKKPK-AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA-IESDMHM 690
P TF +K + +Q + +G L C++ P I W EI ++ +ES
Sbjct: 963 PATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVES---- 1018
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+VL++T+V G Y A N G ++ + KE P + K + V +
Sbjct: 1019 -TAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIV----KESPYFTKEFKPIEVLKEY 1073
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKA-LPTKSDGDTHSITILKPKKV-KDEGVYTLKAE 808
V+L A+V G P ITW K+N +++ K+ H +++ K V D G Y +
Sbjct: 1074 DVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVT 1133
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
N G + SA +T+ EPP FI + + + GT A + + ++TW +
Sbjct: 1134 NEVGSSICSARVTLR-------EPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLK 1186
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
+++ I+ + I F+ L ++ ++ + D G Y C A N AG A +++ E
Sbjct: 1187 DSDEITEDDNIRMTFENNVASLYLSGIEVKHD-GKYVCQAKNDAGIQRCSALLSVK-EPA 1244
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEIS-GMDHR----------EI 975
T + S + +G L+ + S T ++ KW+ + +E++ G ++ +I
Sbjct: 1245 TITEE-AVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKI 1303
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFE-VKEKDVA 1034
I + DVG C K + L++ P F +KL+ + +K +
Sbjct: 1304 ISTEKKDSGEYTFEVQNDVGRSSC--KARINVLDLIIP---PSFTKKLKKMDSIKGSFID 1358
Query: 1035 ILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
+ + S + W +D + I + KY F + L I D G Y+C ++
Sbjct: 1359 LECIVAGSHPISIQWFKDDQEISASE-KYKFSFHDNTAFLEISQLEGTDSGTYTCSATNK 1417
Query: 1095 S----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA--LVRWFKDGSEIQF 1148
+ C+ +TV E PP + + Q+Q VN + + L G A ++WFKD E+
Sbjct: 1418 AGHNQCSGHLTVKE-PPYFVEKPQSQDVNPNTRVQLK-ALVGGTAPMTIKWFKDNKELHS 1475
Query: 1149 SNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
+ D L+++ D+G Y C +VG + A L V+EP P
Sbjct: 1476 GAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPV 1535
Query: 1205 FILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQC 1264
+L + + + V+WY + I +K + T I ++
Sbjct: 1536 LVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSG 1595
Query: 1265 EYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
Y C + T +E+ V+ PP + + + + SDV L + P W+
Sbjct: 1596 TYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK 1655
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
N++ I+ K + +L I K + +D G Y+ + N G V + + PS
Sbjct: 1656 NNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSF 1715
Query: 1384 PGK-PNILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQT-SI 1440
K N + SS + G+ I I ++ + Q +D + + + + T I
Sbjct: 1716 IKKIENTTTVLKSSATF---QSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQI 1772
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+++ S R+ A NE + E + +++E + VEK K++ + +
Sbjct: 1773 RSVDNGHSGRYTCQAKNESGV----ERCYAFLLVQE---PAQIVEK-AKSVDVTEKDPMT 1824
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAK---ATYENR-XXXXXXXXXXXXXXXYKCIAFNDH 1556
L C+ G P+ KV W +DGK++ ++ ++EN Y ND
Sbjct: 1825 LECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDF 1884
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G + + + + + + + KV G + + G P W+K+G ++
Sbjct: 1885 GSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEIST 1944
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+Y + E++ + + L+ ++ YT + SN AG + L V + PS
Sbjct: 1945 SAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPS 1996
Score = 219 bits (534), Expect = 1e-55
Identities = 226/1068 (21%), Positives = 428/1068 (40%), Gaps = 58/1068 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F KKP +G+D+ LEC L P ++W E+ + + E+ +
Sbjct: 4063 PPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSEN----FL 4118
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ + I NV G Y A N G + + +K PP+ ++ L + G+ V
Sbjct: 4119 TSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKA----PPRFVKKLSDISTVVGKEV 4174
Query: 753 ILSAQVVGNPRPTITWCKNN-KPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAEN 809
L + G ++ W K+ + V+ + +I L+ +V+ + G YT + +N
Sbjct: 4175 QLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKN 4234
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ E A ++V EP + + + I V T L V P S W+++
Sbjct: 4235 DAGMQECFATLSV-------LEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKD 4287
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV- 928
+ ++ +F + L I NV + DSG Y N GK S A + + V
Sbjct: 4288 GKELTSDNKYKISFFNKVSGLKIINV-APSDSGVYSFEVQNPVGKDSCTASLQVSDRTVP 4346
Query: 929 -TFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
+F + L+++ G +V++EC+ S +S W+H EIS +
Sbjct: 4347 PSFTRKLKETNGLS-GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALT 4405
Query: 986 XXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEI 1040
D G CI + E S L V+E P F++K +V +V +
Sbjct: 4406 VNMLEESDSGDYTCIATNMAGSDECSAPLTVREP-PSFVQKPDPMDVLTGTNVTFTSIVK 4464
Query: 1041 NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
+ V W + + P ++ + + +L + + GEY+CI+ +E+ A
Sbjct: 4465 GTPPFSVSWFKGSSELVPG-DRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASC 4523
Query: 1101 TV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTI 1156
T ++ P + + RL + + KG E T + V W K+G + S +T
Sbjct: 4524 TTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITT 4583
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPEFILVPANT 1212
K L+I ++DAG+Y+C + G C+A + + EP F +L E + V
Sbjct: 4584 TEKSPILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPY-FVKQL-EPVKVSVGD 4641
Query: 1213 DAYLTVEIPDET-LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV-- 1269
A L ++ + V+WYK + + T + + TL+ + +D EY C
Sbjct: 4642 SASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAE 4701
Query: 1270 --LLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
+ + ++T L V+ + PP R+ + G V + W + K
Sbjct: 4702 NSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKP 4761
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKP 1387
+K + + S +A+L I K + + AG Y N G A + + + +PP
Sbjct: 4762 LKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFD 4821
Query: 1388 -NILEIDSSSINICWDEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKT-QTSIQNLK 1444
+ +D+ E TG I + + + +EI + + + + ++ +
Sbjct: 4822 IRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVD 4881
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI 1504
S ++ YAVNEV + IKE I ++ + + +L
Sbjct: 4882 KGDSGQYTCYAVNEVGKDSCTAQLN----IKERLIPPSFTKRLSETVEETEGNSFKLEGR 4937
Query: 1505 FGGVPQPKVTWYRDGKKLK---TAKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVE 1560
G V WY++ +++ + T++N Y C ND G
Sbjct: 4938 VAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSAL 4997
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
+ + I++ + ++ + E++ ++ ++G P + W K G +++
Sbjct: 4998 CTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRC 5057
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + T+V+ ++++ ++ S Y +ASN AG+ + + + + DKP+
Sbjct: 5058 SFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPA 5105
Score = 218 bits (533), Expect = 2e-55
Identities = 225/903 (24%), Positives = 364/903 (40%), Gaps = 84/903 (9%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
VEK G T EC V G P WF+ + +++ + + V+ L I
Sbjct: 4254 VEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFN-KVSGLKIIN 4312
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGI 632
V P D+G ++ +N G S T L V S+ TV
Sbjct: 4313 VAPSDSGVYSFEVQNPVGKDSCTASLQV--------SDRTV------------------- 4345
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F++K K GS +++EC++ P ++W +G EI + + C
Sbjct: 4346 PPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNT---C 4402
Query: 693 SVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ L + +++ G YT +A N G E S P+ + +EPP ++ M V G
Sbjct: 4403 A-LTVNMLEESDSGDYTCIATNMAGSDECSAPLTV------REPPSFVQKPDPMDVLTGT 4455
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAE 808
+V ++ V G P +++W K + + + S+ L+ V G YT
Sbjct: 4456 NVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVS 4515
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
N G A + + ++ P + F+ R + ++++ + L T P S+TW +
Sbjct: 4516 NEAGKASCTTHLYIKAPAK-------FVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKK 4568
Query: 869 NNEIISPSE--TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
N ++PS+ IT +E+ + V+ D+G Y C N++GK S A++ I +E
Sbjct: 4569 NGINVTPSQRCNITTTEKSPILEIPSSTVE---DAGQYNCYIENASGKDSCSAQILI-LE 4624
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXXX 984
FVK L+ + G + L+CQ + T + WY ++ ++
Sbjct: 4625 PPYFVKQLE-PVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATL 4683
Query: 985 XXXXXXXXDVGVIKC----IVKDQETSTMLVVKE--TIPEFIRKLQDFEVKEKDVAILEV 1038
D G C V + ST L V+E P F R+L+D + + +
Sbjct: 4684 VFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDC 4743
Query: 1039 EIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI----LRD 1093
I+ SE V W +DG+ +K N + L I T G+YSC +
Sbjct: 4744 AISGSEPISVSWYKDGKPLKDSPN-VQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGS 4802
Query: 1094 ESCTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSN 1150
S +A + + E PP RL G A FE +T + V W KD EI+
Sbjct: 4803 ASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGG 4862
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI--NFTLRLPE 1204
Q++ L + D D+G+Y+C EVG CTA L ++E I +FT RL E
Sbjct: 4863 KYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSE 4922
Query: 1205 FILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
+ L + + + V WYK I+ T + L +RK +D
Sbjct: 4923 TVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDA 4982
Query: 1264 CEYTC-VLLDAKS---TTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPND 1319
YTC V DA S T+ + ++ + PP + + G V L Q
Sbjct: 4983 GLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRI 5042
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
+W+ + IK S S +A L ++ V D+G Y + N G + VTI D
Sbjct: 5043 QWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKD 5102
Query: 1380 KPS 1382
KP+
Sbjct: 5103 KPA 5105
Score = 217 bits (529), Expect = 5e-55
Identities = 266/1201 (22%), Positives = 467/1201 (38%), Gaps = 92/1201 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F++K+ T S+ F+ V G P ITW + D Q+ +DDNV
Sbjct: 1713 PSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLK---------DDQILDEDDNVYI-- 1761
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
F S L + + + H T A +L
Sbjct: 1762 --------------------SFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLL 1801
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
P +K K+ V E + LEC + PE + WL G++IVP S++ E+++
Sbjct: 1802 VQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVA 1861
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+ +I +V K G YT N G +S L++ + PP + L M G
Sbjct: 1862 SF----RIQSVMKQDSGQYTFKVENDFGSSSCDAYLRV-LDQNIPPSFTKKLTKMDKVLG 1916
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITI-LKPKKVKDEGVYTLKA 807
S+ + +V G+ + W K+ K + + + S+++ + +++D YT K
Sbjct: 1917 SSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKV 1976
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
N G S ++TV+EP +P R Q I T++ A + P I W+
Sbjct: 1977 SNVAGDDACSGILTVKEPPSFLVKP----GRQQAI---PDSTVEFKAILKGTPPFKIKWF 2029
Query: 868 RNN-EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+++ E++S + +G L + +VD+ +G Y C +N G S + + E
Sbjct: 2030 KDDVELVSGPKCFI-GLEGSTSFLNLYSVDAS-KTGQYTCHVTNDVGSDSCTTMLLV-TE 2086
Query: 927 KVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXX 984
FVK L+ S + G + LEC+ S + W+ N+ E+ D +
Sbjct: 2087 PPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVI 2146
Query: 985 XXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C ++ ST ++VKE P F E + LE E+
Sbjct: 2147 QMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEP-PVFSSFPPIVETLKNAEVSLECEL 2205
Query: 1041 N-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----S 1095
+ + +VVW +D ++ K KY + ++I N D GEY C ++E +
Sbjct: 2206 SGTPPFEVVWYKDKRQLRSSK-KYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDT 2264
Query: 1096 CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSE-IQFSNHIQ 1153
C V + E PP +++L + V G A + + + V+W K+ E I+ S +I+
Sbjct: 2265 CVCTVKLKE-PPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIR 2323
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVP 1209
+T L+ + +AG+Y C++ N + A L V EP++ P + V
Sbjct: 2324 ITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVG 2383
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
V E L V WYK ++ ++K K +L I D YT
Sbjct: 2384 ETCTLECKVAGTPE-LSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQ 2442
Query: 1270 LLD--AKSTTKLKVEVVE--FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI-VN 1324
+ + KS+ V+V + PP + G+ L + W
Sbjct: 2443 VQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEK 2502
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+KI+ K+ + + +L + ++++D G Y N G + +T+ + PS
Sbjct: 2503 TKIVSGAKY-QTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFV 2561
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTSIQNL 1443
+P LE+ N+ + + + +E+ + ++ T + + N+
Sbjct: 2562 KEPEPLEVLPGK-NVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNI 2620
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTC 1503
+ S + N + AS TT + +KE K L + + EP + I L
Sbjct: 2621 DISQSGEYTCVVSN--NAGQASCTTRLF--VKE----PAAFLKRLSDHSVEPGKSIILES 2672
Query: 1504 IFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
+ G VTW +DG + T++ T E Y C N+ G
Sbjct: 2673 TYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRD 2732
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
+V + P E ++ VGD + + G P V WYK KL EY
Sbjct: 2733 VCGALVSTLEPPYFVTELEPLEA--AVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEY 2790
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREIS 1679
+ + ++ + S +YT +A N+ GT+S + ++ ++ P +++I
Sbjct: 2791 RTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIE 2850
Query: 1680 R 1680
+
Sbjct: 2851 Q 2851
Score = 204 bits (498), Expect = 3e-51
Identities = 242/1076 (22%), Positives = 420/1076 (39%), Gaps = 69/1076 (6%)
Query: 633 PPTFSKKPKA-QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP--DENISVAIESDMH 689
PP F KK +A + V G LEC++ PE + W F+ E +P D+ I+S
Sbjct: 2087 PPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVW-FRNEHELPASDKYRMTFIDS--- 2142
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLP--IVLKIKTGEKEPPQVIEPLKSMIVR 747
+V+++ N+ G + A N G S +++K P ++E LK+
Sbjct: 2143 --VAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNA--- 2197
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYT 804
V L ++ G P + W K+ + + K S SI IL D G Y
Sbjct: 2198 ---EVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVD-TSDIGEYH 2253
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
KA+N G + V TV+ EPP F+++ +TV +L A + +
Sbjct: 2254 CKAQNEVG--SDTCVCTVKLK-----EPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFV 2306
Query: 865 TWYRNNE-IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W + E +I SE I F EN+ + ++G Y C N G + A + +
Sbjct: 2307 QWLKEKEEVIRESENIRITFV-ENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMV 2365
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRX 981
+E V+ T G+T LEC+ + T +S +WY + K ++ + +
Sbjct: 2366 -LEPAVIVEKAGPMTVTV-GETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKI 2423
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVV----KETIPEFIRKLQDFEVKEKDVAI 1035
D G V++ ++S VV + P F R+L++ I
Sbjct: 2424 SSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCI 2483
Query: 1036 LEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD- 1093
LE ++ S V W + I KY ++ L + + D G Y+C+ +
Sbjct: 2484 LECKVAGSSPISVAWFHEKTKIVSGA-KYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANV 2542
Query: 1094 ---ESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFS 1149
+ C A +TV E PP + + +V G TF + V WF+ E+
Sbjct: 2543 AGSDECRAVLTVQE-PPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKG 2601
Query: 1150 NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEF 1205
+ + + +L++++ D+ +GEY+C V N+ CT L V+EP+ F RL +
Sbjct: 2602 DRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAA-FLKRLSDH 2660
Query: 1206 ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
+ P + + + VTW K I +EK +++ K L I T+ D +
Sbjct: 2661 SVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQ 2720
Query: 1266 YTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
Y+C + + + V +E PP V G V+L P+ W
Sbjct: 2721 YSCEIENEAGRDVCGALVSTLE-PPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYK 2779
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
++ + + A+L KV D+G Y + EN+ G A + I ++ P
Sbjct: 2780 GDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLP 2839
Query: 1384 PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE---IDTTEWISVKNITKTQTSI 1440
P L+ ++ + S I V Y++ + E + + T +
Sbjct: 2840 PSFARQLKDIEQTVGLPVTLTCRLNGSAPIQ-VCWYRDGVLLRDHENLQTSFVDNVAT-L 2897
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+ L+T+ S+ + + AS + +E K +SP + +I E +
Sbjct: 2898 KILQTDLSHSGQYSCSASNPLGTASSSARL--TAREPK-KSPFFDIKPVSIDVIAGESAD 2954
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFNDH 1556
C G ++TW +D K+++ N Y C A ND
Sbjct: 2955 FECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDV 3014
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
G+ S + +++ P + + + K G+ + I G P +V W++N ++L
Sbjct: 3015 GKDMCSAQLSVKEPPKF-VKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHES 3073
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+YN++ +++ I E S Y EA N G +S L V P + P
Sbjct: 3074 WKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKP 3129
Score = 178 bits (433), Expect = 2e-43
Identities = 171/705 (24%), Positives = 310/705 (43%), Gaps = 56/705 (7%)
Query: 632 IPPTFSKKPKAQYVD-EGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
IPP+F+K+ + EG+ LE R+ +AW EI P N + +++
Sbjct: 4912 IPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNT-- 4969
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
VL++ G YT N G A + IK K+PP + L + V +GE
Sbjct: 4970 --LVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKE-PKKPPVFDQHLTPVTVSEGE 5026
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAE 808
V LS V G+ I W K + +K S +L+ + V D G Y KA
Sbjct: 5027 YVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKAS 5086
Query: 809 NSEGIAETSAVITVEE-----PTEENAEPP---LFINRFQEITVKEKGTIKLVARVTRNP 860
N G T + +T+++ P + A F++ Q I V EK T +A+V +P
Sbjct: 5087 NVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDP 5146
Query: 861 VPSITWYRNN-EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
+P++ W + ++ + + G+ +L I + ++ DSG Y+CVA N G+
Sbjct: 5147 IPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDT-TKTDSGLYRCVAFNEHGEIESNV 5205
Query: 920 RVTIDV----EKV-----TFVKH--LQKSYETEEGKTVILECQTSHTVSTKWYHNKKEIS 968
+ +D EK+ +K + K EE + I+E + V K Y +
Sbjct: 5206 NLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKN--VDPKEYEKYARMY 5263
Query: 969 GM-DHREIIQEGRXXXXXXXXXXXX-DVGVIKCIVKDQETSTMLV------VKETIP-EF 1019
G+ D R ++Q ++ I+ +D++ LV + +T P
Sbjct: 5264 GITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTEPVTL 5323
Query: 1020 IRKLQDFEVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
I+ +++ V + + A+ E++I N + W + E ++P +K++ G L ++
Sbjct: 5324 IKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPS-DKFEISIDGDRHTLRVK 5382
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALV 1137
N + D+G Y + +A++TV+E P LQ+ + +G T ++ + +
Sbjct: 5383 NCQLKDQGNYRLVCGPHIASAKLTVIE--PAWERHLQDVTLKEGQTCTMTVQFSVPNVKS 5440
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSIN 1197
WF++G ++ + ++ K KL I D +D G+Y+C+ + + +A L +E I
Sbjct: 5441 EWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQ 5500
Query: 1198 FTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRK 1257
FT R+ + I+V + A E+ + VTWYK + + +++K+ +D + + I
Sbjct: 5501 FTKRI-QNIVVSEHQSATFECEVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHN 5559
Query: 1258 CTEDDQCEYTCVLL-----DAKSTTKLKVEVVEF-----PPKIVD 1292
T DD+ Y+ + +A+ST +L + E PP I D
Sbjct: 5560 VTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLELKPPDIPD 5604
Score = 126 bits (303), Expect = 1e-27
Identities = 141/602 (23%), Positives = 245/602 (40%), Gaps = 42/602 (6%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
+E P+F + L P +G VQ C V+G +I W + IKPS D +
Sbjct: 5005 KEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPS-DRCSFSFAS 5063
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
A L +R+V D+G + C A N AG S TT+ S++T+
Sbjct: 5064 GTAVLELRDVAKADSGDYVCKASNVAG--SDTTK-----------SKVTIKDKPAVAPAT 5110
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
A + +G F +P++ V E + ++ P P++ W KG+ ++ V
Sbjct: 5111 KKAAV-DG-RLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWT-KGKWRQLNQGGRVF 5167
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS 743
I + L+I + K G Y VA N GE + L++ +K+ ++ L++
Sbjct: 5168 IHQKGDE--AKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQ-EKIEGDLRA 5224
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKP----KKVK 798
M+ + ++ + KN P + + G T +L+ K+ +
Sbjct: 5225 MLKK--TPILKKGAGEEEEIDIMELLKNVDPKEYEKYARMYGITDFRGLLQAFELLKQSQ 5282
Query: 799 DEGVYTLKAENSE----GIAETSAVITVEEPTEENAEPPLFINRFQEITV-KEKGTIKLV 853
+E + L+ E E E +++ + EP I + TV K+ + +
Sbjct: 5283 EEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTEPVTLIKDIENQTVLKDNDAVFEI 5342
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
P ++WY+ E + PS+ + DG+ L + N + D G+Y+ V
Sbjct: 5343 DIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLK-DQGNYRLVC----- 5396
Query: 914 KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDH 972
H A + V + + +HLQ +EG+T + Q S V ++W+ N + +
Sbjct: 5397 -GPHIASAKLTVIEPAWERHLQ-DVTLKEGQTCTMTVQFSVPNVKSEWFRNGRILKPQGR 5454
Query: 973 REIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKD 1032
+ E + D G C +D ETS L ++ +F +++Q+ V E
Sbjct: 5455 HKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKRIQNIVVSEHQ 5514
Query: 1033 VAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
A E E++ + A V W + G + KY+F G + I N + DEG YS I R
Sbjct: 5515 SATFECEVSFDDAIVTWYK-GPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIAR 5573
Query: 1093 DE 1094
E
Sbjct: 5574 LE 5575
Score = 105 bits (253), Expect = 1e-21
Identities = 148/709 (20%), Positives = 270/709 (38%), Gaps = 53/709 (7%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYI 1076
P I LQD E A + ++ V W + IKP + + + +L I
Sbjct: 10 PAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRF-FRMTQFEDTYQLEI 68
Query: 1077 RNTSVHDEGEYSCILRDE----SCTAEVTV------------------VELPPEIITRLQ 1114
DEG Y+ + + S TA +++ ++ P I +++
Sbjct: 69 AEAYPEDEGTYTFVANNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIE 128
Query: 1115 NQKVNKGNKATFEIELTKG-DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDA 1173
+V G+ A F E+ + +WFK G EI S+ + L+I + D
Sbjct: 129 PLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDC 188
Query: 1174 GEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDA-YLTVEIPDETLDVT 1228
GEY+C E G+ CTA LTV E L P+ + A ++ ++
Sbjct: 189 GEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETI 248
Query: 1229 WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE--VVEF 1286
W K + + + + + K L + T D+ Y+C + + E +++
Sbjct: 249 WQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDK 308
Query: 1287 PPKIVDYER-EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
P I + E + I + + VD + W + + + K K + K A+L
Sbjct: 309 PHFIKELEPVQSAINKKVHLECQVDEDR--KVTVTWSKDGQKLPPGKDYKICFEDKIATL 366
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK--PNILEIDSSSINI-CWD 1402
I + D+G Y N G + VT+ + PS K P+ L + S + C
Sbjct: 367 EIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKL 426
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
+ T E E +T V + + I ++K S + AVN D+
Sbjct: 427 KGSPVIQVTWFKNNKELSESNTVRMYFVNS--EAILDITDVKVEDSGSYSCEAVN--DVG 482
Query: 1463 DASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
S +TE VIKE P+ K L+ + L C G +++W++D K++
Sbjct: 483 SDSCSTEI--VIKEP----PSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQI 536
Query: 1523 KTAKA----TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE 1578
+++K + ++ Y+C+ N+ G+ +++ P +
Sbjct: 537 RSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVD 596
Query: 1579 DIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
D+ G + A + G P V W K + D + ++ +V+ I +++ S
Sbjct: 597 DLIALG--GQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQIS 654
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEW 1687
KYT A N AG+ + L V + E +++ + + T+E+
Sbjct: 655 FGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEY 703
Score = 77.0 bits (181), Expect = 7e-13
Identities = 46/120 (38%), Positives = 62/120 (51%), Gaps = 5/120 (4%)
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
G+ A FE ++ A+ W KDGS I+ S + DGK +KL I D L DAGEY+C
Sbjct: 7820 GSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVL 7879
Query: 1179 EVGNSK--CTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVI 1236
+GN + TA L VEE + F L E + V YL+ E+ E DV W K ++
Sbjct: 7880 RLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELNKER-DVVWRKDGKIV 7938
Score = 69.3 bits (162), Expect = 1e-10
Identities = 36/95 (37%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 510 PIFVEKLRP-KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
P FV+KL K G ++Q EC++ G P +++WFR + + S + M + + +VA L
Sbjct: 3029 PKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFIN-SVALL 3087
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
I E ED+G + C A N G AS +T L V+AP
Sbjct: 3088 TINEASAEDSGDYICEAHNGVGDASCSTALTVKAP 3122
Score = 68.1 bits (159), Expect = 3e-10
Identities = 50/162 (30%), Positives = 82/162 (50%), Gaps = 12/162 (7%)
Query: 1018 EFIRKLQDFEVKEKDV----AILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
+F+++++D + E + AI E ++ TA W +DG I+ + K+ F G RK
Sbjct: 7803 KFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIR-ESPKHRFIADGKDRK 7861
Query: 1074 LYIRNTSVHDEGEYSCILR----DESCTAEVTVVELPPEIITRLQNQ-KVNKGNKATFEI 1128
L+I + + D GEY+C+LR +++ TA++ V ELP + L+ + V KG
Sbjct: 7862 LHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSC 7921
Query: 1129 ELTKGDALVRWFKDGS-EIQFSNHIQLTIDGKKQKLKIYDCD 1169
EL K +V W KDG ++ I + G + L I D D
Sbjct: 7922 ELNKERDVV-WRKDGKIVVEKPGRIVPGVIGLMRALTINDAD 7962
Score = 62.9 bits (146), Expect = 1e-08
Identities = 61/267 (22%), Positives = 108/267 (40%), Gaps = 14/267 (5%)
Query: 1216 LTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ ++I + ++WYK +E ++KF + D + TL ++ C DQ Y V
Sbjct: 5342 IDIKINYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVC--GPH 5399
Query: 1276 TTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
K+ V+E P + ++ +K G T+ V + P EW N +I+K K
Sbjct: 5400 IASAKLTVIE--PAWERHLQDVTLKEGQTCTMTVQFSV-PNVKSEWFRNGRILKPQGRHK 5456
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP-PGKPNILEIDS 1394
++ K LTI V D G Y C + D+E + + + P I I
Sbjct: 5457 TEVEHKVHKLTIADVRAEDQGQY------TCKYEDLETSAELRIEAEPIQFTKRIQNIVV 5510
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQ-TSIQNLKTNSSYRFRA 1453
S E E + + I+ + E+ ++ + +N + +I N+ + +
Sbjct: 5511 SEHQSATFECEVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSV 5570
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQ 1480
A E +A T E Y KE K++
Sbjct: 5571 IARLE-PRGEARSTAELYLTTKEIKLE 5596
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 2/126 (1%)
Query: 475 MDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVE 534
+D N+ +Y+ K N + ++ T +EQ + P F +LR G V F+C +
Sbjct: 4688 VDINDSGEYICKAENS-VGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAIS 4746
Query: 535 GYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASS 594
G ++W++ +K S + Q + DN ATL I + AG ++C A N G ASS
Sbjct: 4747 GSEPISVSWYKDGKPLKDSPNVQTSF-LDNTATLNIFKTDRSLAGQYSCTATNPIGSASS 4805
Query: 595 TTELIV 600
+ LI+
Sbjct: 4806 SARLIL 4811
Score = 56.0 bits (129), Expect = 1e-06
Identities = 29/100 (29%), Positives = 49/100 (49%), Gaps = 1/100 (1%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
+E+ + P F +L+ G V C++ G Q+ W+R +++ ++ Q + D
Sbjct: 2834 QERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDHENLQTSFVD- 2892
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
NVATL I + +G ++C A N G ASS+ L P
Sbjct: 2893 NVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREP 2932
Score = 54.4 bits (125), Expect = 4e-06
Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
++++ P F +L+ G++ EC+V G + WF + I +Q + D N
Sbjct: 2460 DRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSD-N 2518
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
V TL + + D G +TCVA N AG L V+ P S
Sbjct: 2519 VCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPS 2559
Score = 52.4 bits (120), Expect = 2e-05
Identities = 31/130 (23%), Positives = 65/130 (50%), Gaps = 3/130 (2%)
Query: 475 MDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPK-HTPDGSTVQFECQV 533
+D+ + QY +NE + K + +E+ + P F ++L +G++ + E +V
Sbjct: 4880 VDKGDSGQYTCYAVNE-VGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRV 4938
Query: 534 EGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFAS 593
G + W++ I+P+ + ++ + + N L +R+ DAG +TC N AG A
Sbjct: 4939 AGSQPITVAWYKNNIEIQPTSNCEITFKN-NTLVLQVRKAGMNDAGLYTCKVSNDAGSAL 4997
Query: 594 STTELIVEAP 603
T+ ++++ P
Sbjct: 4998 CTSSIVIKEP 5007
Score = 48.8 bits (111), Expect = 2e-04
Identities = 25/102 (24%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
TS + PIF +K P T G+ V EC+++G P ++W++ ++ + +++
Sbjct: 4056 TSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKI-MS 4114
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
++ + ++ I V D G + C A N G + + ++AP
Sbjct: 4115 ENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAP 4156
Score = 47.6 bits (108), Expect = 5e-04
Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 1/101 (0%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
+Q++ P F +KL GS++ EC+V G WF+ I S +++ + +
Sbjct: 1897 DQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERS 1956
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
V +L + + ED +TC N AG + + L V+ P S
Sbjct: 1957 V-SLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPS 1996
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 2/95 (2%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA-IIKPSQDFQMYYDDDNVATL 568
P FV+KL T G V+ VEG+ + W + +I+ S++ ++ + D N+ATL
Sbjct: 3216 PRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFID-NIATL 3274
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ ++G + C KN AG + L V P
Sbjct: 3275 QLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEP 3309
Score = 46.8 bits (106), Expect = 9e-04
Identities = 28/102 (27%), Positives = 41/102 (40%), Gaps = 1/102 (0%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E+ E AP+ K+ P G +F C+++ P + WF+ I S D
Sbjct: 110 EQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYES-DKCS 168
Query: 559 YYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+++L I D G +TC A N G S T L V
Sbjct: 169 IRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 210
Score = 45.2 bits (102), Expect = 0.003
Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 1/102 (0%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
T+ E +P F K G + FEC V G +ITW + I+P ++ +
Sbjct: 2928 TAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITC- 2986
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
N L I +V D+G +TC A N G + +L V+ P
Sbjct: 2987 VGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEP 3028
Score = 44.4 bits (100), Expect = 0.005
Identities = 42/163 (25%), Positives = 68/163 (41%), Gaps = 9/163 (5%)
Query: 1196 INFTLRLPEFILVPAN---TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
+ F + + IL + + A + T TW K S I ++ K I+D K R
Sbjct: 7802 LKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRK 7861
Query: 1253 LIIRKCTEDDQCEYTCVLL--DAKSTTKLKVEVVEFPPKIV-DYEREYRIKRGSDVTLLV 1309
L I D EYTCVL + + T+ K+ V E P + V E E + +G + L
Sbjct: 7862 LHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSC 7921
Query: 1310 DYQAFPQPNDEWIVNSKI-IKKCKHTKPSIDSKSASLTIKKVE 1351
+ + + W + KI ++K P + +LTI +
Sbjct: 7922 ELN--KERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDAD 7962
Score = 42.3 bits (95), Expect = 0.018
Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 4/139 (2%)
Query: 830 AEPPLFINRFQEITVKEKGTI--KLVARVTRNPVPSIT-WYRNNEIISPSETITQNFDGE 886
A P F+ ++I + E + + +P +IT W ++ I S DG+
Sbjct: 7799 AVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIADGK 7858
Query: 887 NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTV 946
+ +L I +V D+G+Y CV + + A++ ++ V FVK L++ +G+ +
Sbjct: 7859 DRKLHIIDVQLS-DAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPL 7917
Query: 947 ILECQTSHTVSTKWYHNKK 965
L C+ + W + K
Sbjct: 7918 YLSCELNKERDVVWRKDGK 7936
Score = 40.3 bits (90), Expect = 0.074
Identities = 21/81 (25%), Positives = 37/81 (45%), Gaps = 1/81 (1%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+F +K P GS V +C++ G P ++ W + ++ S+ F++ + L
Sbjct: 3123 PVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFD-TNLH 3181
Query: 570 IREVFPEDAGTFTCVAKNAAG 590
I + D G + C A N G
Sbjct: 3182 ILNLEASDVGEYHCKATNEVG 3202
Score = 39.1 bits (87), Expect = 0.17
Identities = 61/258 (23%), Positives = 102/258 (39%), Gaps = 20/258 (7%)
Query: 173 PPQNIIEEAKSEPKLIEESEQPIAKTSEIDNE-VPE-KINVPDDKETSQTPTSFNKRSKL 230
PP+ ++ E K ++ E P K E E VPE K+ VP K+ PT K ++
Sbjct: 7165 PPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPT---KVPEV 7221
Query: 231 TPIKIERKEMEVSTPQHAETVDGPQFXXXXXXXXXXXXXXETSLVKLPKFQLK-SRIKYI 289
+ K++ + P E+ F E V++P+ + K +
Sbjct: 7222 PKAAVPEKKVPEAIPPKPESPPPEVFEEPEESPSAPPKKPEVPPVRVPEVPKEVVPEKKV 7281
Query: 290 TSWPPESIKPLISYMGSIKQNGILSRNIKEAAKVKKQVFVPP-KLPDVEKTELEQPLFSY 348
+ PP+ KP ++ + + + K K+ VPP K+P+V K + +
Sbjct: 7282 PAAPPK--KPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPE 7339
Query: 349 EDIVESKKDENEIIQEKQ--TLEELPKEDV-------PEQYTITPRKSSAQKIDEIVDEV 399
+ + E+ +E + LEE P E V P Q T+ P+ +K V V
Sbjct: 7340 AIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKNPVPEKKAPAV--V 7397
Query: 400 TIKKRLNPFEIFYTPVEV 417
K L P ++ P EV
Sbjct: 7398 AKKPELPPVKVPEVPKEV 7415
Score = 37.5 bits (83), Expect = 0.52
Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 3/63 (4%)
Query: 149 ERVTLEK--SDLFDSQEDESKPDVSQPPQNIIEEAKSEPKLIEESEQPIAKTSEIDNE-V 205
E V LE+ +++ + E + P V+ PP+N + E K+ + ++ E P K E+ E V
Sbjct: 7357 EEVALEEPPAEVVEEPEPAAPPQVTVPPKNPVPEKKAPAVVAKKPELPPVKVPEVPKEVV 7416
Query: 206 PEK 208
PEK
Sbjct: 7417 PEK 7419
Score = 36.7 bits (81), Expect = 0.91
Identities = 56/273 (20%), Positives = 103/273 (37%), Gaps = 14/273 (5%)
Query: 150 RVTLEKSDLFDSQEDESKPDVSQP--PQNIIEEAKSEPKLIEESEQPIAKTSEIDNEV-- 205
++T E+ L + E+ P P P+ + E K + E+P AK +E V
Sbjct: 6307 QITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVK 6366
Query: 206 PEKINVPDDKETSQTPTSFN-KRSKLTPIKIERKEMEVSTPQHAETVDGPQFXXXXXXXX 264
EK+++ K Q K +E + + V + E + +
Sbjct: 6367 EEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEP 6426
Query: 265 XXXXXXETSLVKLPKFQLKSRIKYITS-WPPESIKPLISYMGSIKQNGILSRNIKEAAKV 323
+ + + +YIT P +KP+ K ++ +K+A
Sbjct: 6427 TEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPE 6486
Query: 324 KK-QVFVPPKLPDVEKTELEQPLFSYEDIVE---SKKDENEIIQEKQTLEELPKEDVPEQ 379
+K V +P KL E+P +E+ + +K+++ ++ + + PK V E+
Sbjct: 6487 EKVPVPIPKKLKPPPPKVPEEPKKVFEEKIHISITKREKEQVTEPAAKVPMKPKRVVAEE 6546
Query: 380 YTITPRKSSAQKIDEIVDEVTIKKRLNPFEIFY 412
PRK A + V EV K L P E+ +
Sbjct: 6547 KVPVPRKEVAPPVR--VPEV--PKELEPEEVAF 6575
Score = 36.3 bits (80), Expect = 1.2
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 174 PQNIIEEAKSEPKLIEESEQPIAKTSEIDNEVPEKINVPDDKETSQTPTSFNKRSKLTPI 233
P + EE + EP EE + E++ P ++ K + PT K+ + P
Sbjct: 6899 PVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPA 6958
Query: 234 KIERKEMEVSTPQHAETVDGP 254
K+ +K E P + + P
Sbjct: 6959 KVSKKIPEEKVPVPVQKKEAP 6979
Score = 35.9 bits (79), Expect = 1.6
Identities = 50/244 (20%), Positives = 97/244 (39%), Gaps = 20/244 (8%)
Query: 170 VSQPPQNIIEEAKSEPKLIEESEQPIAKTSEIDNEVPEKINVPDDKETSQTPTSFNKRSK 229
V + P+ + E K + ++ E P AK E+ + EK+ V K+ P + K
Sbjct: 6615 VPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPK 6674
Query: 230 LTPIKIERKEMEVSTPQHAETVDGPQFXXXXXXXXXXXXXXETSLVKLPKFQLKSRIKYI 289
P+ E+ + V A P+ V+ P ++ K +
Sbjct: 6675 -KPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKK-VEAPPAKVPEVPKKL 6732
Query: 290 TSWPPESIKPLISYMGSIKQNGILSRNIKEAAKVKKQVFVPPKLPDVEKTELEQPLFSYE 349
PE KP + + + + K ++ V VP LP E+ E+ + E
Sbjct: 6733 I---PEEKKPT-----PVPKK--VEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEE 6782
Query: 350 DIVESKKD----ENEIIQEKQTLEELPKED--VPEQYTITPRKSSAQKIDEIVDEVTIKK 403
+++ +++ E E++ E++ E LP+E+ PE+ + P + + +E V E +
Sbjct: 6783 EVLPEEEEVLPEEEEVLPEEE--EVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLP 6840
Query: 404 RLNP 407
+ P
Sbjct: 6841 EVKP 6844
Score = 35.9 bits (79), Expect = 1.6
Identities = 27/79 (34%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQIT-WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
GS+ FEC V P IT W + + I+ S + D + L I +V DAG +T
Sbjct: 7820 GSSAIFECLVS--PSTAITTWMKDGSNIRESPKHRFIADGKD-RKLHIIDVQLSDAGEYT 7876
Query: 583 CVAKNAAGFASSTTELIVE 601
CV + +ST +L+VE
Sbjct: 7877 CVLRLGNKEKTSTAKLVVE 7895
Score = 35.1 bits (77), Expect = 2.8
Identities = 52/244 (21%), Positives = 90/244 (36%), Gaps = 20/244 (8%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXXXXXX 1538
P E+ L+++T + + +T F VP K W+R+G+ LK K E++
Sbjct: 5410 PAWERHLQDVTLKEGQTCTMTVQFS-VPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTI 5468
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE- 1597
+ D +ETS + I+ +P+ Q V + T E
Sbjct: 5469 ADVRAEDQGQYTCKYED---LETSAELRIEAEPIQFTKRI---QNIVVSEHQSATFECEV 5522
Query: 1598 GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI--------EASN 1649
V WYK +L ++YN + + I + Y++ EA +
Sbjct: 5523 SFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARS 5582
Query: 1650 TAGTSSVEVTLKVYDKPSK-PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
TA +K+ KP P+ V + + +V E PP+ + L E+ +P
Sbjct: 5583 TAELYLTTKEIKLELKPPDIPDSRVPIPTMPIRAVPPEEIPPVVAPPVPLLLPTPEEKKP 5642
Query: 1709 DNNR 1712
R
Sbjct: 5643 PPKR 5646
>X69490-1|CAA49245.1| 4650|Homo sapiens titin protein.
Length = 4650
Score = 252 bits (617), Expect = 1e-65
Identities = 197/757 (26%), Positives = 325/757 (42%), Gaps = 35/757 (4%)
Query: 1218 VEIPDETLDVTWYK--KKSVIEDTEKFTLISDVK---KRTLIIRKCTEDDQCEYTCVLLD 1272
+E+ ++ D WY+ + I +TE FT + D+K K + + EY+ + +
Sbjct: 605 LEMQEKDTD-QWYRVHTNATIRNTE-FT-VPDLKMGQKYSFRVAAVNVKGMSEYSESIAE 661
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
+ ++++ +E D ++ I+ G+ + L+V P P W + + I
Sbjct: 662 IEPVERIEIPDLELAD---DLKKTVTIRAGASLRLMVSVSGRPPPVITW--SKQGIDLAS 716
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ L + KV DAG Y + EN G + V + D P P + E+
Sbjct: 717 RAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEV 776
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRF 1451
S+ I W+ P G + I Y+VE +E + +V +KT I L + + F
Sbjct: 777 SRDSVTITWEIPTIDGGAPINNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMHYF 836
Query: 1452 RAYAVNEVDISDASETTEYYKV----IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
R N I + ET++ V + K++ V K + E + + G
Sbjct: 837 RVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGY 896
Query: 1508 VPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE---TSCV 1564
V + K+ T K T ++ A N+ G E T
Sbjct: 897 VLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYL---FRIRAQNEKGVSEPRETVTA 953
Query: 1565 VGIQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
V +Q P I +S K H G + I G PPP W+ G+KL +
Sbjct: 954 VTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVT 1013
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
+ T K + + I+E + +YT+E N GT+ + + + DKP P GP+ + EI
Sbjct: 1014 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTLETIKVIILDKPGPPTGPIKIDEIDA 1073
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD-VDRDVETYCIQKLNENCEYMF 1739
S+TI W+PP DGG L+ Y +E+ + W+ V++ V R T+ +L E EY+F
Sbjct: 1074 TSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTR--STFKFTRLTEGNEYVF 1131
Query: 1740 RVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
RV A N G L+SE I ++++ +P + + + +TW+P E +GGS +
Sbjct: 1132 RVAATNRFGIGSYLQSEVIECRSSIRIPG-PPETLQIFDVSRDGMTLTWYPPEDDGGSQV 1190
Query: 1800 IDYKVEIKQ-EGKKWKXXXXXXXXXARIQK--LSINTTYQFRIYARNEIGTSLPYTSDDK 1856
Y VE K+ +W R + L+ Y+ R+ A N G+ P
Sbjct: 1191 TGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKP 1250
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
I + PP +P+N V+++T SV+L W+ PE GGS +T Y+IE + V WTK
Sbjct: 1251 IVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCN 1310
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
T + E+ + ++ + E FR+ A N G P E
Sbjct: 1311 TTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAE 1347
Score = 243 bits (594), Expect = 6e-63
Identities = 176/609 (28%), Positives = 276/609 (45%), Gaps = 30/609 (4%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
DKPS PG+ IL I S+ + W++PE G I+ Y VEY++ + W + + I
Sbjct: 1656 DKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDK 1715
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
Q +I L + Y FR +A NE +S T K K T ++P + K +K++TT+
Sbjct: 1716 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKT-KLTSGEAPGIRKEMKDVTTKLG 1774
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXXXXXXXXXXX-YKCIA 1552
E +L+C G P P + WYR GK+L + K + + R Y CIA
Sbjct: 1775 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 1834
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIKQKH--KVGDEWLVTAVIEGIPPPEVIWYKNG 1610
N+ GEVETS + +Q P +K+K+ VG + + G P P + W+
Sbjct: 1835 TNEVGEVETSSKLLLQATPQFH-PGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQ 1893
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKR-SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
L+N + I E + + +K ++R +H+ KY ++ SN GT + +++ DKP KP
Sbjct: 1894 KLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKP 1953
Query: 1670 EGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQ 1729
GP+++ + + S I WKPP DDGG +T Y +EK E ++ V T I
Sbjct: 1954 TGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIV 2013
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW 1788
L EN Y FRV AQN G S+ LE S ++IK+ + P + +S + W
Sbjct: 2014 NLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPG-APGKPTITAVTKDSCVVAW 2072
Query: 1789 FPSEKNGGSPIIDYKVEIKQEGK--KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNE 1844
P +GG+ I +Y +E K+E K KW ++ L Y+FR+ N
Sbjct: 2073 KPPASDGGAKIRNYYLE-KREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENL 2131
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQP------RNFVVSESTSRSVTLKWTEPESNGGSPIT 1898
G S + IT K+ P P RN V ++ ++ K T PI
Sbjct: 2132 GGESEWSEISEPIT-PKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVT----GHPKPIV 2186
Query: 1899 NYIIEFKTVKGKSWT-KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
+ + K + +I G H+ I ++ + D ++++ A N G T S V
Sbjct: 2187 KWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 2246
Query: 1958 RLEKHATVP 1966
+ +P
Sbjct: 2247 EVPAKIHLP 2255
Score = 222 bits (542), Expect = 1e-56
Identities = 207/895 (23%), Positives = 362/895 (40%), Gaps = 51/895 (5%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKSVIEDTEKFTLISDVKKRT 1252
P+I+ + + I VPA L + I +W+ S + ++E+ T+ + K
Sbjct: 963 PTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAK 1022
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQ 1312
L IR+ T D EYT L + TT ++V+ K +I ++ + ++
Sbjct: 1023 LTIRETTIRDTGEYTLELKNVTGTTLETIKVIILD-KPGPPTGPIKIDEIDATSITISWE 1081
Query: 1313 AFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT---IKKVENTDAGIYKLRLE--NNCG 1367
P+ + ++ ++++ +P S S+T K T+ Y R+ N G
Sbjct: 1082 P-PELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFG 1140
Query: 1368 HADVEMNVTI-----LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI 1422
+ I + P PP I ++ + + W PE+ G S + Y+VE +E+
Sbjct: 1141 IGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEV 1200
Query: 1423 DTTEWISVKNITKTQTSIQN--LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ 1480
W+ V + T T ++ L Y R A+N S ++ ++ I
Sbjct: 1201 RADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSK--PIVAMDPIA 1258
Query: 1481 SP-TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR------DGKKLKTAKATYENRX 1533
P + P TT + + + + KVT Y D + T
Sbjct: 1259 PPGKPQNPRVTDTTRTSVSLAWS-VPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIR 1317
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVG-IQQKPVITISNEDIKQKH------KV 1586
++ +A N G E + V G ++ ++ + ++ +++ +
Sbjct: 1318 EYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQ 1377
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G +T I+G P P W K G + K I T E + + IKE R S Y +
Sbjct: 1378 GGVIRLTIPIKGKPFPICKWTKEGQDIS--KRAMIATSETHTELVIKEADRGDSGTYDLV 1435
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKH 1706
N G +V + ++V P+ PEGP+ +I SV + W+PP DDGG ++ Y +E+
Sbjct: 1436 LENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERR 1495
Query: 1707 EPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTALD 1765
E W + R + ++ L EN EY FRV A+N G S+ L+S EP+ KT L+
Sbjct: 1496 EVPKAAWYTIDSRVRGT-SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLN 1554
Query: 1766 VPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXX 1822
P + SV ++W + +GGS + Y +E K+
Sbjct: 1555 PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKVVRHNKTQITTT 1614
Query: 1823 XARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSV 1882
+ L + YQFRI A+N++G S + + + PSQP + + SV
Sbjct: 1615 MYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSV 1674
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TL+W +PE +GG I Y +E++ +W K + I + E E FR+ A
Sbjct: 1675 TLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFA 1734
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
EN G+S P + ++ ++ T P E++ V + + G A L
Sbjct: 1735 ENETGLSRPRRT-AMSIKTKLTSGEAPGIRKEMKDVTTKL-----------GEAAQLSCQ 1782
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
I R + W GK + + K+ + HT + + + G+ + ++E
Sbjct: 1783 IVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNE 1837
Score = 219 bits (534), Expect = 1e-55
Identities = 158/601 (26%), Positives = 279/601 (46%), Gaps = 37/601 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS- 1439
PS P +P + + +++++I W+EP + G S II Y VE +E +T W+ + + +
Sbjct: 68 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 127
Query: 1440 -IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP-------TVEKPLKNI 1491
+ L Y+FR YA+N +S ASE + ++ + + +P + I
Sbjct: 128 KVTGLVEGLEYQFRTYALNAAGVSKASEASR--PIMAQNPVDAPGRPGVTDVQRSTVSLI 185
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCI 1551
+ P D + + + V+ DG+ LK T + ++ +
Sbjct: 186 WSAPAYDGGSKVVGYIIERKPVSEVGDGRWLK-CNYTIVSDNFFTVTALSEGDTYEFRVL 244
Query: 1552 AFNDHGEV----ETSCVVGIQQKPVITISNEDIKQKH-----KVGDEWLVTAVIEGIPPP 1602
A N G + E++ V + + + D + + G + ++ A + G P P
Sbjct: 245 AKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEP 304
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++IW K +L+ ++ ++ K + IK RS S KYT+ N +GT +V V +KV
Sbjct: 305 KIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 364
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
D P P G + + +++E T+ W P +DGG E+T Y +E+ E W+ + + +
Sbjct: 365 LDSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWV-IVEGECP 422
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+Y + +L +N EY+FRV A N G +ESEPIV + + +PS E
Sbjct: 423 TLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGT-GKE 481
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKW---KXXXXXXXXXARIQKLSINTTYQFR 1838
+ I W E +GG+ I +Y V+ ++ E +W ++ L YQFR
Sbjct: 482 HIIIQWTKPESDGGNEISNYLVDKREKESLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFR 541
Query: 1839 IYARNEIGTSLPYTSDDKITIGK---TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGS 1895
+ A N G S P + I+ + T PPS PR V ++T S++L WT+P +GG+
Sbjct: 542 VTAVNAAGNSEPSERSNFISCREPSYTPGPPSAPR---VVDTTKHSISLAWTKPMYDGGT 598
Query: 1896 PITNYIIEFKTVKGKSWTKIVTVGGSVH--EHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
I Y++E + W ++ T ++ E + ++K + FR++A N G+S +E
Sbjct: 599 DIVGYVLEMQEKDTDQWYRVHT-NATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSE 657
Query: 1954 S 1954
S
Sbjct: 658 S 658
Score = 219 bits (534), Expect = 1e-55
Identities = 171/693 (24%), Positives = 291/693 (41%), Gaps = 26/693 (3%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP P +++ SI++ W +P G + I+ YV+E QE DT +W V I T+
Sbjct: 569 PGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE 628
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPN 1496
++ +LK Y FR AVN +S+ SE+ + ++ +I + LK +T
Sbjct: 629 FTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAG 688
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFN 1554
+ L G P P +TW + G L + T E+ Y A N
Sbjct: 689 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAEN 748
Query: 1555 DHGEVETSCVVGIQQKP--VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
G+ + +V + P ++ +++ + V W + + G P I K
Sbjct: 749 QSGKKSATVLVKVYDTPGPCPSVKVKEVS-RDSVTITWEIPTIDGGAPINNYIVEKREAA 807
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+ K +TTK ++ RI L + + N G T P P
Sbjct: 808 MRAFK--TVTTKCSKTLYRISGLVEGTMHYFRVLPENIYGIGEPCETSDAVLVSEVPLVP 865
Query: 1673 VIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQK 1730
+ ++++ +VT+ W+ PL DGG LT Y +E + RW+KV + V + +
Sbjct: 866 AKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTS 925
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV-PSXXXXXXXXXXIDNESVYITWF 1789
LNE +Y+FR+ AQN G SE E+ V L V P+ I +
Sbjct: 926 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVEL 985
Query: 1790 PSEKNGGSPIID---YKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
G P + +E ++ I++ +I T ++ + +N G
Sbjct: 986 VIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTG 1045
Query: 1847 TSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT 1906
T+L K+ I PP+ P + E + S+T+ W PE +GG+P++ Y++E +
Sbjct: 1046 TTLETI---KVIILDKPGPPTGP--IKIDEIDATSITISWEPPELDGGAPLSGYVVEQRD 1100
Query: 1907 VKGKSWTKIV-TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATV 1965
W + +V S + + E +E +FR++A N G+ +S+ + +
Sbjct: 1101 AHRPGWLPVSESVTRSTFK--FTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRI 1158
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP L+I V + + +W PE DGG+ + GY + ++V W+ V KV V +
Sbjct: 1159 PGPPET-LQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTR 1217
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ L+E Y R+ A N G +P +P
Sbjct: 1218 YRSTGLTEGLEYEHRVTAINARGSGKPSRPSKP 1250
Score = 215 bits (524), Expect = 2e-54
Identities = 228/896 (25%), Positives = 369/896 (41%), Gaps = 72/896 (8%)
Query: 1204 EFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
+ + + A +D L + + + W K ++ EK +L K+ T +I+ C D
Sbjct: 282 DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSD 341
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-- 1320
+YT + +A T + V V K++D S VT A+ P ++
Sbjct: 342 SGKYTLTVKNASGTKAVSVMV-----KVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGG 396
Query: 1321 -----WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA-DVEMN 1374
+IV + + + + S + ++ + I+++R N G VE
Sbjct: 397 AEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESE 456
Query: 1375 VTILDK----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV 1430
+ PSPPG P + I I W +PE+ G + I Y+V+ +E ++ W V
Sbjct: 457 PIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKESLRWTRV 516
Query: 1431 KN---ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP----- 1482
+ T+ + +L Y+FR AVN S+ SE + + + + P
Sbjct: 517 NKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSERSNFISCREPSYTPGPPSAPR 576
Query: 1483 ---TVEKPLKNITTEPNEDIELTCIFGGV--PQPKVT--WYRDGKKLKTAKATYENRXXX 1535
T + + T+P D T I G V Q K T WYR AT N
Sbjct: 577 VVDTTKHSISLAWTKPMYDGG-TDIVGYVLEMQEKDTDQWYR-----VHTNATIRN-TEF 629
Query: 1536 XXXXXXXXXXXXYKCIAFNDHGEVETS-CVVGIQQKPVITISN----EDIKQKHKV--GD 1588
++ A N G E S + I+ I I + +D+K+ + G
Sbjct: 630 TVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGA 689
Query: 1589 EWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEAS 1648
+ + G PPP + W K G L + I T E S++ + ++ R + KYTIEA
Sbjct: 690 SLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLIVDKVNRYDAGKYTIEAE 747
Query: 1649 NTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
N +G S V +KVYD P P V ++E+SR+SVTI W+ P DGG + Y +EK E
Sbjct: 748 NQSGKKSATVLVKVYDTPG-PCPSVKVKEVSRDSVTITWEIPTIDGGAPINNYIVEKREA 806
Query: 1709 DNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPS 1768
R K Y I L E + FRV+ +N G E E+ V+ + +VP
Sbjct: 807 AM-RAFKTVTTKCSKTLYRISGLVEGTMHYFRVLPENIYGIGEPCETSDAVLVS--EVP- 862
Query: 1769 XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARIQ 1827
+ +V + W +GGS + Y +E + G ++W
Sbjct: 863 LVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHT 922
Query: 1828 KLSINT--TYQFRIYARNEIGTSLPYTSDDKITIGK-----TLTPPSQPRNFVVSESTSR 1880
S+N Y FRI A+NE G S P + +T+ T+ + P+ + R
Sbjct: 923 VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQK-TIHVPAGR 981
Query: 1881 SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
V L P + P ++ ++ +S V V + I +D + +
Sbjct: 982 PVEL--VIPIAGRPPPAASWFFAGSKLR-ESERVTVETHTKVAKLTIRETTIRDTGEYTL 1038
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
+N G +L T + + L+K P PPT P++I + + + SW PE DGGAPL G
Sbjct: 1039 ELKNVTGTTLET-IKVIILDK----PGPPTGPIKIDEIDATSITISWEPPELDGGAPLSG 1093
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
Y + RD + W+ V + V F L+E + Y+ R+ A N G+ L+S+
Sbjct: 1094 YVVEQRDAHRPGWLPVSE-SVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 1148
Score = 196 bits (479), Expect = 5e-49
Identities = 168/659 (25%), Positives = 291/659 (44%), Gaps = 41/659 (6%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVE 1192
++W++ G E+ S +++ DG+ L + + +D G Y+C EVG + ++ L ++
Sbjct: 1791 IKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ 1850
Query: 1193 E-PSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKK 1250
P + L E + L V + +TW+ + +++++E T+ +
Sbjct: 1851 ATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHY 1910
Query: 1251 RTLIIRKCTEDDQC-EYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
L+++ +Y L + T L VE+ + P K + + S V
Sbjct: 1911 THLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAV-- 1968
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPS---IDSKSASLTIKKVENT--DAGIY-KLR 1361
+ ++ WI N +++KC+ + + + S + S+T ++ N +AG Y ++
Sbjct: 1969 -ISWKPPADDGGSWITNY-VVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVS 2026
Query: 1362 LENNCGHAD-VEMNVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
+N G +D +E++ ++ +KP PGKP I + S + W P + G + I Y
Sbjct: 2027 AQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNY 2086
Query: 1416 VVEYQEIDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
+E +E +WISV + I +T S++NL Y FR N S+ SE +E
Sbjct: 2087 YLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITP 2146
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRX 1533
+ IQ+P ++ L+N+ + L C G P+P V WYR GK++ Y +
Sbjct: 2147 KSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQE 2206
Query: 1534 XXXX------XXXXXXXXXXYKCIAFNDHGEVE--TSCVVGIQQKPVITISNEDIKQKHK 1585
Y+ A N G V S V + K + + E + H
Sbjct: 2207 FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHA 2266
Query: 1586 V-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN-ITTKEKTSVIRIKELKRSHSSKY 1643
+ G+ + G P P + W K + ++N+ Y I T+ TS++ ++R + Y
Sbjct: 2267 LRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFY 2326
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAI 1703
+ A N G V L V D P P G V + + SR+SV + W P DGG ++T Y +
Sbjct: 2327 VVCAKNRFGIDQKTVELDVADVPDPPRG-VKVSDASRDSVNLTWTEPASDGGSKITNYIV 2385
Query: 1704 EKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIK 1761
EK RW++V R+ Y + L Y FRVIA+N G S+ E SEP + K
Sbjct: 2386 EKCATTAERWLRVGQA-RETR-YTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITK 2442
Score = 184 bits (448), Expect = 3e-45
Identities = 216/967 (22%), Positives = 388/967 (40%), Gaps = 83/967 (8%)
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLT 1217
G+K ++ ++ EYS + ++ + +E P + L + + + A L
Sbjct: 637 GQKYSFRVAAVNVKGMSEYSESI--AEIEPVERIEIPDLELADDLKKTVTIRAGASLRLM 694
Query: 1218 VEIPDETLDV-TWYKK------KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
V + V TW K+ +++I+ TE ++L LI+ K D +YT
Sbjct: 695 VSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL--------LIVDKVNRYDAGKYTIEA 746
Query: 1271 LD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
+ K + + V+V + P ++K S ++ + ++ P + +N+ I+
Sbjct: 747 ENQSGKKSATVLVKVYDTPGPCPSV----KVKEVSRDSVTITWE-IPTIDGGAPINNYIV 801
Query: 1329 KKCKHTKPSIDSKSA--SLTIKKVENTDAGI---YKLRLENNCG---HADVEMNVTILDK 1380
+K + + + + S T+ ++ G +++ EN G + V + +
Sbjct: 802 EKREAAMRAFKTVTTKCSKTLYRISGLVEGTMHYFRVLPENIYGIGEPCETSDAVLVSEV 861
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKT--QT 1438
P P K ++++ S++ + W++P G S + YV+E + T W+ V + T +
Sbjct: 862 PLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEH 921
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE---KPLKNITTEP 1495
++ +L Y FR A NE +S+ ET +++ ++ PT++ P K I
Sbjct: 922 TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV-TVQDLRV-LPTIDLSTMPQKTIHVPA 979
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFN 1554
+EL G P P +W+ G KL+ + + T E
Sbjct: 980 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRET--------TIR 1031
Query: 1555 DHGE--VETSCVVG--IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK-- 1608
D GE +E V G ++ VI + DE T++ PPE+
Sbjct: 1032 DTGEYTLELKNVTGTTLETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPL 1091
Query: 1609 NGNKLENDKEYN-----ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+G +E + ++ S + L + + + A+N G S + +
Sbjct: 1092 SGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIE 1151
Query: 1664 DK-----PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
+ P PE I ++SR+ +T+ W PP DDGG ++T Y +E+ E +RW++V
Sbjct: 1152 CRSSIRIPGPPETLQIF-DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNK 1210
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXX 1777
V + Y L E EY RV A N G + + S+PIV + P
Sbjct: 1211 VPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPI-APPGKPQNPRVT 1269
Query: 1778 XIDNESVYITWFPSEKNGGSPIIDYKVEI-KQEGKKWKXXXXXXXXXAR--IQKLSINTT 1834
SV + W E GGS + Y +E+ K + +W + L
Sbjct: 1270 DTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAE 1329
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESN 1892
Y+FR+ A N G P + + + L P + E + ++ T P
Sbjct: 1330 YRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKG 1389
Query: 1893 GGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
PI + E + + ++ ++ + E I+ D + + EN G
Sbjct: 1390 KPFPICKWTKEGQDISKRA---MIATSETHTELVIKEADRGDSGTYDLVLENKCG----K 1442
Query: 1953 ESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM 2012
++ +++ + P+ P PLE + V SW P DGGA +LGY + R+V K
Sbjct: 1443 KAVYIKVRVIGS-PNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAA 1501
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEE 2072
W + V ++ L EN Y R+ A N+ G+S+PL+S+EP V P + E
Sbjct: 1502 WYTIDS-RVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEP--VTPKTPLNPPEP 1558
Query: 2073 PGEQTEV 2079
P EV
Sbjct: 1559 PSNPPEV 1565
Score = 153 bits (370), Expect = 9e-36
Identities = 112/414 (27%), Positives = 181/414 (43%), Gaps = 14/414 (3%)
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P KP+ P + + +R SV++ W P D+GG ++T Y IE + D + W K +
Sbjct: 1260 PGKPQNPRVT-DTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIRE 1318
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV-IKTALDVPSXXXXXXXXXXID-NES 1783
Y + L + EY FRV+A N G E E V + L+ P I +
Sbjct: 1319 YTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQG 1378
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
I K PI + E + K+ I++ + + + N
Sbjct: 1379 GVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLEN 1438
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
+ G Y K+ + + P P + + RSV + W P +GG+ I YI+E
Sbjct: 1439 KCGKKAVYI---KVRVIGSPNSPEGPLEY--DDIQVRSVRVSWRPPADDGGADILGYILE 1493
Query: 1904 FKTVKGKSWTKIVT-VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQS-VRLEK 1961
+ V +W I + V G+ ++ +KE E FR+SAEN G+S P +S+ V +
Sbjct: 1494 RREVPKAAWYTIDSRVRGT--SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKT 1551
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
P PP+ P E+ V + V SW P+ DGG+ + GY I ++ + + K +
Sbjct: 1552 PLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKVVRHNKTQI 1611
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
T + + L + Y RI A+N++GLSE + EP V+ + +PGE
Sbjct: 1612 TTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEP--VVCKDPFDKPSQPGE 1663
Score = 136 bits (328), Expect = 1e-30
Identities = 196/790 (24%), Positives = 318/790 (40%), Gaps = 70/790 (8%)
Query: 1214 AYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL- 1271
A L+ +I L D+ WY+ + + K+ + SD + TL + ++D+ YTC+
Sbjct: 1777 AQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATN 1836
Query: 1272 ---DAKSTTKLKVEVV-EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
+ ++++KL ++ +F P E+ Y GS + L V Y P P W K+
Sbjct: 1837 EVGEVETSSKLLLQATPQFHPGYPLKEKYYGAV-GSTLRLHVMYIGRPVPAMTWFHGQKL 1895
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVE-NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
++ ++ L +K V+ T AG YK++L N G D ++V I DKP P
Sbjct: 1896 LQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTG 1955
Query: 1387 PNILE-IDSSSINICWDEPENTGNSTIIYYVVEYQEI-DTTEWISVKN-ITKTQTSIQNL 1443
P ++E + +S I W P + G S I YVVE E + EW V + I+ T I NL
Sbjct: 1956 PIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNL 2015
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTC 1503
N+ Y FR A N ISD E + VI ++ + P P K T +D +C
Sbjct: 2016 TENAGYYFRVSAQNTFGISDPLEVSSV--VIIKSPFEKPGA--PGKPTITAVTKD---SC 2068
Query: 1504 IFGGVPQ-----PKVTWY----RDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIA 1552
+ P K+ Y R+ K+ K T E Y +
Sbjct: 2069 VVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKC 2128
Query: 1553 FNDHGEVETSCV-VGIQQKPVITISNEDIKQKHK---VGDEWLVTAV--IEGIPPPEVIW 1606
N GE E S + I K + I K++ + V + T V + G P P V W
Sbjct: 2129 ENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKW 2188
Query: 1607 YKNGNKLEND-KEYNITT-KEKTSVIRIKELKRSHSSKYTIEASNTAGTSS------VEV 1658
Y+ G ++ D +Y I K + I + ++ Y + A+N G+ S VEV
Sbjct: 2189 YRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEV 2248
Query: 1659 TLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
K++ P EG + + E V+I K P + + + DNN +V
Sbjct: 2249 PAKIH-LPKTLEGMGAVHALRGEVVSI--KIPFSGKPDPVITWQKGQDLIDNNGHYQVI- 2304
Query: 1719 VDRDVETYCIQKLNENCEYMFRVI-AQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXX 1777
V R + E + F V+ A+N G ++ + + + A DVP
Sbjct: 2305 VTRSFTSLVFPNGVERKDAGFYVVCAKNRFG----IDQKTVELDVA-DVPDPPRGVKVSD 2359
Query: 1778 XIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWKXXXXXXXXXARIQKLSINTTYQ 1836
+SV +TW +GGS I +Y VE ++W + L T+YQ
Sbjct: 2360 A-SRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQ 2418
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
FR+ A N+ G S P + T+T + R E + + T+ +
Sbjct: 2419 FRVIAENKFGLSKPSEPSE-----PTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKE 2473
Query: 1897 I-TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQ 1955
+ Y+I +G+ G VH C+E +K + + + T V + E
Sbjct: 2474 LYEKYMIAEDLGRGEF--------GIVH-RCVETSSKKTYMAKFVKVKGTDQVLVKKEIS 2524
Query: 1956 SVRLEKHATV 1965
+ + +H +
Sbjct: 2525 ILNIARHRNI 2534
Score = 121 bits (292), Expect = 2e-26
Identities = 144/607 (23%), Positives = 240/607 (39%), Gaps = 44/607 (7%)
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAK-ATYENRXXXXXXXXXX----XXXXXYKCIAF 1553
+ L ++ G P P +TW+ K L+ ++ T EN YK
Sbjct: 1873 LRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLS 1932
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV--IWYKNG- 1610
N G V+ V IQ KP I+ K +AVI PP + W N
Sbjct: 1933 NVFGTVDAILDVEIQDKPDKPTGPIVIEALLKN------SAVISWKPPADDGGSWITNYV 1986
Query: 1611 -NKLENDK--EYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAG------TSSVEVTL 1660
K E + E+ + + + RI L + + + A NT G SSV +
Sbjct: 1987 VEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIK 2046
Query: 1661 KVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVD 1720
++KP P P I ++++S + WKPP DGG ++ Y +EK E N+WI V +
Sbjct: 2047 SPFEKPGAPGKPTITA-VTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEE 2105
Query: 1721 RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXI 1779
+ ++ L E EY FRV +N G SE E SEPI K+ + + +
Sbjct: 2106 IRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLN 2165
Query: 1780 DNESVYITWFPSEKNGGSPIIDYK---VEIKQEGKKWKXXXXXXXXXARI-QKLSINTTY 1835
T PI+ + EI +G K++ I ++ +
Sbjct: 2166 VRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDAT 2225
Query: 1836 QFRIYARNEIGTSLPYTSDDKITI-GKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
+++ A N+ G S+ T+ ++ + K P + V V++K P S
Sbjct: 2226 VYQVRATNQ-GGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI--PFSGKP 2282
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
P+ + + +++ ++ KD + + A+N G+ +
Sbjct: 2283 DPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI----DQ 2338
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
++V L+ A VP PP +++ + V +W P DGG+ + Y + T W+
Sbjct: 2339 KTVELDV-ADVPDPPRG-VKVSDASRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWL 2396
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP--FKVIPGEGSHADEE 2072
VG+ ++ + +L +Y R+ A N+ GLS+P E EP K + DEE
Sbjct: 2397 RVGQA--RETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITKEDKTRAMNYDEE 2454
Query: 2073 PGEQTEV 2079
E EV
Sbjct: 2455 VDETREV 2461
Score = 108 bits (259), Expect = 2e-22
Identities = 108/453 (23%), Positives = 188/453 (41%), Gaps = 31/453 (6%)
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV-----YDKPSKPEGPVIM 1675
+ + K + I++ L + + + + N G S + + + PS P P +
Sbjct: 18 VNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVY 77
Query: 1676 REISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENC 1735
+S +++I W+ P DGG ++ Y +EK E + W+K V Y + L E
Sbjct: 78 H-VSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGL 136
Query: 1736 EYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKN 1794
EY FR A N G S+A E S PI+ + +D P + +V + W +
Sbjct: 137 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPG----RPGVTDVQRSTVSLIWSAPAYD 192
Query: 1795 GGSPIIDYKVEIKQEGK----KWK--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGT- 1847
GGS ++ Y +E K + +W + LS TY+FR+ A+N G
Sbjct: 193 GGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVI 252
Query: 1848 SLPYTSDDKITIGKTLTPPSQPRNF-VVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT 1906
S S +T PP + + + + + GG P II K
Sbjct: 253 SKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK-IIWTKG 311
Query: 1907 VKGKSWTKIVTV--GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHAT 1964
K + V++ G I+ D + ++ +N G T++ SV ++
Sbjct: 312 DKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASG----TKAVSVMVK---V 364
Query: 1965 VPSP-PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
+ SP P L + V +W P+ DGGA + Y + R+ ++ W+ V + + T
Sbjct: 365 LDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIV-EGECPT 423
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
L + + L +N+ Y+ R+ A N+ G P+ES+
Sbjct: 424 LSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESE 456
Score = 104 bits (249), Expect = 4e-21
Identities = 81/313 (25%), Positives = 140/313 (44%), Gaps = 19/313 (6%)
Query: 523 DGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G V++ C++E Y + Q+TW+ ++ S+ +++ Y+D VA L ++++ D GT+
Sbjct: 2808 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYED-GVAILYVKDITKLDDGTY 2866
Query: 582 TCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
C N G SS EL V+ + D+ T+ +LE PP F+
Sbjct: 2867 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMR---LLER-PPEFTLP 2922
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHMYCSVLKIT 698
+ G ++ + PEP + W G++I P D + ESD +Y L I
Sbjct: 2923 LYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLY--QLTIN 2980
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV-----RQGESVI 753
+V + YTVVA N+ GE S L + + P+ ++ ++G+SV
Sbjct: 2981 SVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVC 3040
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYTLKAENS 810
+V G P PT+ W K+ +P+ P +G + ++ +D G Y + A N+
Sbjct: 3041 FEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNT 3100
Query: 811 EGIAETSAVITVE 823
G A + VE
Sbjct: 3101 AGSTSCQAHLQVE 3113
Score = 103 bits (247), Expect = 7e-21
Identities = 172/833 (20%), Positives = 326/833 (39%), Gaps = 71/833 (8%)
Query: 736 QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK 795
+++ +SM V +GES S G P PT+TW + + + T + +
Sbjct: 3789 RILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGRVLSTSARHQVTTTKYKSTFEIS 3848
Query: 796 KVK--DEGVYTLKAENSEGIAETSAVITVEEP--TEENAEPPLFINRFQEITVKEKGTIK 851
V+ DEG Y++ ENSEG E +T+++ TE+ P + + E VK +K
Sbjct: 3849 SVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRV-KSPEPRVKSPEAVK 3907
Query: 852 LVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNS 911
RV ++P PS + + +SP+ET E ++ + + +I K AS
Sbjct: 3908 SPKRV-KSPEPS-----HPKAVSPTETKPTPI--EKVQHLPVSAPPKITQF-LKAEASKE 3958
Query: 912 AGKSSHGARVTI-DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGM 970
K + ++ ++VT+ K +K E + T K + + G
Sbjct: 3959 IAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQ---FHYSADGTYELKINNLTESDQGE 4015
Query: 971 DHREIIQEGRXXXXXXXXXXXXDVGVIKCIVK-------DQETSTMLVVKETIPE----- 1018
EI EG + + + K DQ+T+ V ++T P+
Sbjct: 4016 YVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPI 4075
Query: 1019 -----FIRKLQDFEVKEKDVAILEVEINSETADV-VWERDGEII-KPKKNKYDFEKRGHI 1071
+ LQD V VA V+ E +W +DG+ I + K K +K G
Sbjct: 4076 SSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFF 4135
Query: 1072 RKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELT 1131
L I T D G Y+C +++ + + + +L + I + QKV+ + T EI
Sbjct: 4136 --LEIHKTDTSDSGLYTCTVKNSAGSVSSSC-KLTIKAIKDTEAQKVS--TQKTSEITPQ 4190
Query: 1132 KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY--SCEVGNSKCTAI- 1188
K A+V+ ++ S I+++ ++KL + + +A + S EV S T++
Sbjct: 4191 K-KAVVQEEISQKALR-SEEIKMSEAKSQEKLALKE----EASKVLISEEVKKSAATSLE 4244
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDE------------TLDVTWYKKKSVI 1236
++ I T + E + A A+ T +E DV W +
Sbjct: 4245 KSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVEL 4304
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-----VEFPPKIV 1291
++E++ +TL I++ + D+ TC+ + K + ++ + P +
Sbjct: 4305 TNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFI 4364
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
R I G +V + P P EW N+ I + S SL I+
Sbjct: 4365 SQPRSQNINEGQNVLFTREISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNAS 4424
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+D+G Y ++ +N G ++ +L P + +L S ++ + +
Sbjct: 4425 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLR-TSGDTSLQGSFSSQSVQMS 4483
Query: 1412 IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
+ ++ S+ + S Q++ + + + + IS+ ++
Sbjct: 4484 ASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESST 4543
Query: 1472 KVIKETKIQS--PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ + I+ P +E +I+ + + + + C F G P P+VTW G+K+
Sbjct: 4544 SKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI 4596
Score = 95.5 bits (227), Expect = 2e-18
Identities = 60/204 (29%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 713 VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN 772
++R ++ I K+ +GE P + + +K + + GE+ LS Q+VG P P I W +
Sbjct: 1740 LSRPRRTAMSIKTKLTSGEA--PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFG 1797
Query: 773 KPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
K + + SDG TH++T++ ++ +DEGVYT A N G ETS+ + ++ + +
Sbjct: 1798 KELIQSRKYKMSSDGRTHTLTVMTEEQ-EDEGVYTCIATNEVGEVETSSKLLLQATPQFH 1856
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE 889
PL + + T++L PVP++TW+ +++ SE IT
Sbjct: 1857 PGYPLKEKYYGAVG----STLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTH 1912
Query: 890 LVITNVDSEIDSGDYKCVASNSAG 913
LV+ NV + +G YK SN G
Sbjct: 1913 LVMKNVQRKTHAGKYKVQLSNVFG 1936
Score = 92.3 bits (219), Expect = 2e-17
Identities = 73/265 (27%), Positives = 115/265 (43%), Gaps = 12/265 (4%)
Query: 1801 DYKVEIKQEGKK-WKXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKIT 1858
+Y VE ++ G W+ ++ L+ Y FR+ + N G S P S I
Sbjct: 2 NYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAP-II 60
Query: 1859 IGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV 1918
PPS P V ++ +++++W EP +GGS I Y +E K W K V
Sbjct: 61 AEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKV 120
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRM 1977
+ + + E E FR A N GVS +E S+ + + P P +
Sbjct: 121 PCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRP----GVTD 176
Query: 1978 VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKT---MWMEVGKVDVNTLKFNIRDLSEN 2034
V + V W P +DGG+ ++GY I + V++ W++ V+ F + LSE
Sbjct: 177 VQRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEG 236
Query: 2035 HTYMIRIYARNEIG-LSEPLESDEP 2058
TY R+ A+N G +S+ ES P
Sbjct: 237 DTYEFRVLAKNAAGVISKGSESTGP 261
Score = 79.0 bits (186), Expect = 2e-13
Identities = 149/701 (21%), Positives = 258/701 (36%), Gaps = 54/701 (7%)
Query: 639 KPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKIT 698
KP++ V EG C P P + WL KG + V Y S +I+
Sbjct: 3793 KPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGRVLSTSARHQVTTTK----YKSTFEIS 3848
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQV 758
+V+ EG Y+VV N EG+ L I+ V P + V+ E + S +
Sbjct: 3849 SVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPR---VKSPEPRVKSPEA 3905
Query: 759 VGNPR----PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V +P+ P + K P + PT + H + + P K+ LKAE S+ IA
Sbjct: 3906 VKSPKRVKSPEPSHPKAVSPTETKPTPIEKVQH-LPVSAPPKI----TQFLKAEASKEIA 3960
Query: 815 E-----TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKL-VARVTRNPVPSITWYR 868
+ S+V+ +E T L N + GT +L + +T +
Sbjct: 3961 KLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEI 4020
Query: 869 NNEIISPSETITQNFDGENIELVITNVD--SEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+ E S+T Q F G+ + + V SE D K S K+ A I
Sbjct: 4021 SGE-GGTSKTNLQ-FMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPIS-S 4077
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHTVSTK-WYHNKKEISGMDHREIIQEGRXXXXX 985
K V LQ + + + T T W + K I+ ++ ++
Sbjct: 4078 KPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLE 4137
Query: 986 XXXXXXXDVGVIKCIVKDQETS-------TMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
D G+ C VK+ S T+ +K+T + + + E+ + A+++
Sbjct: 4138 IHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQE 4197
Query: 1039 EINSETADVVWERDGEI-IKPKKNKYDFEKRGHIRKLYIR---NTSVHDEGEYSCILRDE 1094
EI+ + R EI + K++ + K+ I S E S + +
Sbjct: 4198 EISQKAL-----RSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEI 4252
Query: 1095 SCTAEVT-VVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
+ T++ + V EI +N+G + + + G V+W +G E+ S +
Sbjct: 4253 TKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIA-GATDVKWVLNGVELTNSEEYR 4311
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTV--EEPSINFTLRLPEFIL 1207
+ G Q L I D G +C + G KC LT+ E + P
Sbjct: 4312 YGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQN 4371
Query: 1208 VPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
+ + T EI E + ++ W+K I + ++ +L IR + D +Y
Sbjct: 4372 INEGQNVLFTREISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 4431
Query: 1267 TCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
T + + ++ P + + RE ++ D +L
Sbjct: 4432 TIKAKNFRGQCSATASLMVL-PLVEEPSREVVLRTSGDTSL 4471
Score = 71.7 bits (168), Expect = 3e-11
Identities = 72/330 (21%), Positives = 133/330 (40%), Gaps = 40/330 (12%)
Query: 646 DEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+EG + C++ + + W F ++ E + E + ++L + ++ K
Sbjct: 2807 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGV----AILYVKDITKLD 2862
Query: 705 EGTYTVVAVNREGEASLPIVLKIK------------TGEK------------EPPQVIEP 740
+GTY VN GE S L +K T +K PP+ P
Sbjct: 2863 DGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLP 2922
Query: 741 LKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV------KALPTKSDGDTHSITILKP 794
L + GE+V + +P P +TW K+ + + K +SD + +TI
Sbjct: 2923 LYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTI-NS 2981
Query: 795 KKVKDEGVYTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKL 852
D+ YT+ A N E + +T+ P ++ P+F +E ++
Sbjct: 2982 VTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCF 3041
Query: 853 VARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSA 912
RV+ P P++ W ++ + +S I +G + + D+G Y+ A+N+A
Sbjct: 3042 EIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTA 3101
Query: 913 GKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
G +S + + VE++ + K KS E E
Sbjct: 3102 GSTS--CQAHLQVERLRYKKQEFKSKEEHE 3129
Score = 64.5 bits (150), Expect = 4e-09
Identities = 80/400 (20%), Positives = 138/400 (34%), Gaps = 13/400 (3%)
Query: 1282 EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
E + P IV ++ + S V P+P W + K I + K S D
Sbjct: 4073 EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKG 4132
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD-KPSPPGKPNILEIDSSSINIC 1400
L I K + +D+G+Y ++N+ G +TI K + K + + +
Sbjct: 4133 GFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKK 4192
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE-- 1458
E + ++ E + E +++K + +K +++ V+E
Sbjct: 4193 AVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEI 4252
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
S ASE + IK Q E + ++ + GV YR
Sbjct: 4253 TKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRY 4312
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK--PVITIS 1576
G T + CI+ G V+ + + ++
Sbjct: 4313 GVSGSDQTLTIKQASHRDEGILT--------CISKTKEGIVKCQYDLTLSKELSDAPAFI 4364
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELK 1636
++ Q G L T I G P PE+ W+KN + +I+ + I+
Sbjct: 4365 SQPRSQNINEGQNVLFTREISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNAS 4424
Query: 1637 RSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
S S KYTI+A N G S +L V +P V++R
Sbjct: 4425 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLR 4464
Score = 63.7 bits (148), Expect = 7e-09
Identities = 74/299 (24%), Positives = 129/299 (43%), Gaps = 15/299 (5%)
Query: 319 EAAKVKKQVF--VPPKLPDVEKTELEQPLFSYEDIVESK-KDENEIIQEKQTLEELPKED 375
EA KV Q + P+ V + E+ Q E+I S+ K + ++ +++ + L E+
Sbjct: 4175 EAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEE 4234
Query: 376 VPEQYTITPRKSSAQKIDEIVDEVTIKKRLNP-FEIFYTPVEVRCGDTVFAVYSYVAETD 434
V + + KS + + + + R + + F T + + G + + TD
Sbjct: 4235 VKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATD 4294
Query: 435 EAINLVEGERLYILDTSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDK 494
++ G L T+++++ Y + A + DE T K E I K
Sbjct: 4295 VKW-VLNGVEL----TNSEEYRYGVSGSDQTLTIKQASH-RDEGILTCI--SKTKEGIVK 4346
Query: 495 LPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ 554
++ S+E S AP F+ + R ++ +G V F ++ G P P+I WF+ I S
Sbjct: 4347 CQ-YDLTLSKELSDAPAFISQPRSQNINEGQNVLFTREISGEPSPEIEWFKNNLPISISS 4405
Query: 555 DFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTV 613
+ + NV +L IR D+G +T AKN G S+T L+V PL + S V
Sbjct: 4406 NVSI-SRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV-LPLVEEPSREVV 4462
Score = 62.9 bits (146), Expect = 1e-08
Identities = 63/281 (22%), Positives = 113/281 (40%), Gaps = 14/281 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIEL-TKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P I R+++ +V G F + + +K A V+W+ +G E+Q S+ I T L+I
Sbjct: 3601 PRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEI 3660
Query: 1166 YDCDLDDAGEYSCEVGNSK--CTAILTVEEPSINFTLRLPE--FILVPANTDAYLTVEIP 1221
DC DD+G Y N K + T++ ++T + VP + LT
Sbjct: 3661 LDCHTDDSGTYRAVCTNYKGERSDYATLDVTGGDYTTYASQRRDEEVPRSVFPELT---R 3717
Query: 1222 DETLDVTWYKKKSVIEDTEKFTLI-SDVKKRTLIIRKCTEDDQCEYTCVLLDAKS----T 1276
E V +KK S +E + + S + + + E L+ KS +
Sbjct: 3718 TEAYAVPSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKS 3777
Query: 1277 TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
T K++ +I+ R + G D P P W+ +++ +
Sbjct: 3778 TTRKIKTT-LAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGRVLSTSARHQV 3836
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ ++ I V+ +D G Y + +EN+ G + E +TI
Sbjct: 3837 TTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTI 3877
Score = 61.7 bits (143), Expect = 3e-08
Identities = 82/345 (23%), Positives = 146/345 (42%), Gaps = 28/345 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F ++ + V S+ L C++ P+P + W +G+EI+ D + I+ Y
Sbjct: 2155 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIAD-GLKYRIQEFKGGYHQ 2213
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK-EPPQVIEPLKSMIVRQGESV 752
++ I +V Y V A N+ G S L+++ K P+ +E + ++ +GE V
Sbjct: 2214 LI-IASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVV 2272
Query: 753 ILSAQVVGNPRPTITWCK------NNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ G P P ITW K NN + + T+S S+ + KD G Y +
Sbjct: 2273 SIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRS---FTSLVFPNGVERKDAGFYVVC 2329
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLV-ARVTRNPVPSIT 865
A+N GI + TVE + +PP R +++ + ++ L + IT
Sbjct: 2330 AKNRFGIDQK----TVELDVADVPDPP----RGVKVSDASRDSVNLTWTEPASDGGSKIT 2381
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTI 923
Y + + +E + + N+ + S ++ +A N G K S + TI
Sbjct: 2382 NYIVEKCATTAERWLRVGQARETRYTVINLFGK-TSYQFRVIAENKFGLSKPSEPSEPTI 2440
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEIS 968
E T + + E +E + V + + SH+ STK + K I+
Sbjct: 2441 TKEDKT--RAMNYDEEVDETREVSM-TKASHS-STKELYEKYMIA 2481
Score = 60.9 bits (141), Expect = 5e-08
Identities = 60/235 (25%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++++ T G Q CQ+ G P P I W+R + S+ ++M D TL
Sbjct: 1759 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKM-SSDGRTHTL 1817
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
+ ED G +TC+A N G ++++L+++A H
Sbjct: 1818 TVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFH--------------------- 1856
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
P + K K Y GS + L + P P + W F G++++ + ++ IE+
Sbjct: 1857 -----PGYPLKEK-YYGAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQNSE-NITIENTE 1908
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPL 741
H V+K +K G Y V N G +A L + ++ K + P VIE L
Sbjct: 1909 HYTHLVMKNVQ-RKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEAL 1962
Score = 60.5 bits (140), Expect = 6e-08
Identities = 48/209 (22%), Positives = 84/209 (40%), Gaps = 10/209 (4%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ G P K+ K G L C++V P PDI W G+E++ ++ +
Sbjct: 1754 LTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGR 1813
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV- 746
H L + ++ EG YT +A N GE L ++ + P PLK
Sbjct: 1814 TH----TLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGY--PLKEKYYG 1867
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDE---GVY 803
G ++ L +G P P +TW K ++ + +T T L K V+ + G Y
Sbjct: 1868 AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKY 1927
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEP 832
++ N G + + +++ ++ P
Sbjct: 1928 KVQLSNVFGTVDAILDVEIQDKPDKPTGP 1956
Score = 60.1 bits (139), Expect = 9e-08
Identities = 61/251 (24%), Positives = 95/251 (37%), Gaps = 34/251 (13%)
Query: 480 YTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRP 539
Y + KK+ + D + + E+P P F L K G V+F + +P P
Sbjct: 2895 YCRRTMKKIKRRTDTMRLLERP--------PEFTLPLYNKTAYVGENVRFGVTITVHPEP 2946
Query: 540 QITWFRQTAIIKPSQDFQMY--YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTE 597
+TW++ IKP + + Y D + L I V +D +T VA+N G S +
Sbjct: 2947 HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 3006
Query: 598 LIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
L V L ++ T + P F + EG + E R+
Sbjct: 3007 LTV--TLHPPPTDST-------------------LRPMFKRLLANAECQEGQSVCFEIRV 3045
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
IP P + W G+ + NI + I + Y L I + G Y V A N G
Sbjct: 3046 SGIPPPTLKWEKDGQPLSLGPNIEI-IHEGLDYY--ALHIRDTLPEDTGYYRVTATNTAG 3102
Query: 718 EASLPIVLKIK 728
S L+++
Sbjct: 3103 STSCQAHLQVE 3113
Score = 60.1 bits (139), Expect = 9e-08
Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 20/166 (12%)
Query: 1047 VVWERDGEIIKPKKN--KYDFEKRGHIRKLYIRNTSVHDEGEYSCILR----DESCTAEV 1100
V W + G+ IKP N KY FE + +L I + + D+ EY+ + R ++SC A++
Sbjct: 2948 VTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKL 3007
Query: 1101 TVVELPPEIITRLQ--------NQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNH 1151
TV PP + L+ N + +G FEI ++ ++W KDG + +
Sbjct: 3008 TVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPN 3067
Query: 1152 IQLTIDG-KKQKLKIYDCDLDDAGEY----SCEVGNSKCTAILTVE 1192
I++ +G L I D +D G Y + G++ C A L VE
Sbjct: 3068 IEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVE 3113
Score = 60.1 bits (139), Expect = 9e-08
Identities = 83/402 (20%), Positives = 148/402 (36%), Gaps = 60/402 (14%)
Query: 541 ITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ W + S++++ Y + TL I++ D G TC++K G +L +
Sbjct: 4295 VKWVLNGVELTNSEEYR-YGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTL 4353
Query: 601 EAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAI 660
LSD P F +P++Q ++EG ++L +
Sbjct: 4354 SKELSD--------------------------APAFISQPRSQNINEGQNVLFTREISGE 4387
Query: 661 PEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEAS 720
P P+I W I N+S++ +++ L+I N G YT+ A N G+ S
Sbjct: 4388 PSPEIEWFKNNLPISISSNVSISRSRNVYS----LEIRNASVSDSGKYTIKAKNFRGQCS 4443
Query: 721 LPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPT 780
L + P V EP + +++R L G+ +K + +
Sbjct: 4444 ATASLMVL------PLVEEPSREVVLRTSGDTSLQ----GSFSSQSVQMSASKQEASFSS 4493
Query: 781 KSDGDTHSITILKPKKVKDEGVYTLKAE----NSEGIAETSAVITVEEPTEENAE----- 831
S S+T +K + + + +++ +S S + +E T + +
Sbjct: 4494 FSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRG 4553
Query: 832 -PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE- 889
PP +I++ E + + T P P +TW I E F EN +
Sbjct: 4554 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQE--QGRFHIENTDD 4611
Query: 890 ---LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
L+I +V + D G Y N G S A V I + +
Sbjct: 4612 LTTLIIMDVQKQ-DGGLYTLSLGNEFGSDS--ATVNIHIRSI 4650
Score = 58.8 bits (136), Expect = 2e-07
Identities = 65/275 (23%), Positives = 110/275 (40%), Gaps = 31/275 (11%)
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSY-RFRAYAVNEVDISDASETTEYY-- 1471
Y + Y+ D + VK+ITK K + Y +YA E+ + E +YY
Sbjct: 2842 YEITYE--DGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYA--ELFVKGVREVYDYYCR 2897
Query: 1472 KVIKETKIQSPTVEK---------PLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ +K+ K ++ T+ PL N T E++ P+P VTWY+ G+K+
Sbjct: 2898 RTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKI 2957
Query: 1523 KTA----KATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGE--VETSCVVGIQQKPVI 1573
K K T+E+ Y +A N +GE + V + P
Sbjct: 2958 KPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTD 3017
Query: 1574 TISNEDIKQ-----KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KT 1627
+ K+ + + G + GIPPP + W K+G L I +
Sbjct: 3018 STLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDY 3077
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ I++ + Y + A+NTAG++S + L+V
Sbjct: 3078 YALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 3112
Score = 58.8 bits (136), Expect = 2e-07
Identities = 36/128 (28%), Positives = 56/128 (43%), Gaps = 2/128 (1%)
Query: 476 DENNYTQYLQKKLNEKI--DKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQV 533
D+ YT + K E KL V P + ++ P+F L +G +V FE +V
Sbjct: 2986 DDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRV 3045
Query: 534 EGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFAS 593
G P P + W + + + ++ ++ + L IR+ PED G + A N AG S
Sbjct: 3046 SGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTS 3105
Query: 594 STTELIVE 601
L VE
Sbjct: 3106 CQAHLQVE 3113
Score = 56.0 bits (129), Expect = 1e-06
Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 1/108 (0%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMY 559
P S+ AP F E+LR + S C+V G+P+P + W+RQ II +++
Sbjct: 2146 PKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQ 2205
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDH 607
L+I V +DA + A N G S T L VE P H
Sbjct: 2206 EFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIH 2253
Score = 54.4 bits (125), Expect = 4e-06
Identities = 69/320 (21%), Positives = 129/320 (40%), Gaps = 32/320 (10%)
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYE-------REYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
L + T++ K EV+ P +D+ R +R+ G + +++ Q+ P +W
Sbjct: 3577 LKTQKTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYH 3636
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD--VEMNVTILDKP 1381
N +++ + S +L I D+G Y+ N G ++VT D
Sbjct: 3637 NGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGERSDYATLDVTGGDYT 3696
Query: 1382 SPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS----VKN-ITKT 1436
+ + E+ S PE T T Y V +++ E S VK+ +T+T
Sbjct: 3697 TYASQRRDEEVPRSVF------PELT--RTEAYAVPSFKKTSEMEASSSVREVKSQMTET 3748
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
+ S+ + + ++S ++ A+ E + + S T + +T + + + KP +++T
Sbjct: 3749 RESLSSYEHSASAEMKSAALEEKSLEEKSTTRKI-----KTTLAARILTKP-RSMTVYEG 3802
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIA 1552
E +C G P P VTW R G+ L T+ T + + Y +
Sbjct: 3803 ESARFSCDTDGEPVPTVTWLRKGRVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVV 3862
Query: 1553 FNDHGEVETSCVVGIQQKPV 1572
N G+ E + IQ+ V
Sbjct: 3863 ENSEGKQEAEFTLTIQKARV 3882
Score = 52.8 bits (121), Expect = 1e-05
Identities = 35/169 (20%), Positives = 68/169 (40%), Gaps = 4/169 (2%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
AEN G++ + + E P +++T K +L ++ P+P I W
Sbjct: 1734 AENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKW 1793
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
YR + + S + DG L + + E D G Y C+A+N G+ +++ +
Sbjct: 1794 YRFGKELIQSRKYKMSSDGRTHTLTVMTEEQE-DEGVYTCIATNEVGEVETSSKLLLQAT 1852
Query: 927 KVTFVKH-LQKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDH 972
+ L++ Y G T+ L + W+H +K + ++
Sbjct: 1853 PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSEN 1901
Score = 52.0 bits (119), Expect = 2e-05
Identities = 36/131 (27%), Positives = 66/131 (50%), Gaps = 5/131 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLP-IVLKIKTGEK-EPP--QVIEPLKSMI-VRQGES 751
+ ++K Q+ ++ V AVN +G + + +I+ E+ E P ++ + LK + +R G S
Sbjct: 631 VPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGAS 690
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L V G P P ITW K + + +++S+ I+ D G YT++AEN
Sbjct: 691 LRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQS 750
Query: 812 GIAETSAVITV 822
G + ++ V
Sbjct: 751 GKKSATVLVKV 761
Score = 51.6 bits (118), Expect = 3e-05
Identities = 86/445 (19%), Positives = 152/445 (34%), Gaps = 33/445 (7%)
Query: 540 QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELI 599
++TW++ +K + FQ +Y D L I + D G + C G + + + +
Sbjct: 3975 EVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFM 4034
Query: 600 VEAPLSDHGSEMTVXXXXXXXXXXXXADILE----GIPPTFSKKP----KAQYVDEGSDI 651
+A S H + + + P S KP Q SD
Sbjct: 4035 GQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDS 4094
Query: 652 LLECRLVAI--PEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYT 709
+ + + A P P W G+ I + + D + L+I G YT
Sbjct: 4095 VAKFAVKATGEPRPTAIWTKDGKAIT--QGGKYKLSEDKGGF--FLEIHKTDTSDSGLYT 4150
Query: 710 VVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNP-RPTITW 768
N G S L IK + Q + K+ + + ++ ++ R
Sbjct: 4151 CTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIK 4210
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL-KAENSEGIAETSAVITVEEPTE 827
K + L K + +L ++VK +L K+ E I +TS E
Sbjct: 4211 MSEAKSQEKLALKEEAS----KVLISEEVKKSAATSLEKSIVHEEITKTS---QASEEVR 4263
Query: 828 ENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGEN 887
+AE F ++++ E + L A + + W N ++ SE G +
Sbjct: 4264 THAEIKAFST---QMSINEGQRLVLKANIA--GATDVKWVLNGVELTNSEEYRYGVSGSD 4318
Query: 888 IELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
L I S D G C++ G K + ++ ++ +S EG+
Sbjct: 4319 QTLTIKQA-SHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQN 4377
Query: 946 VILECQTSHTVS--TKWYHNKKEIS 968
V+ + S S +W+ N IS
Sbjct: 4378 VLFTREISGEPSPEIEWFKNNLPIS 4402
Score = 51.2 bits (117), Expect = 4e-05
Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 4/120 (3%)
Query: 486 KKLNEKIDKLPVFEK--PTSEEQ-SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQIT 542
KK ++K + V K P + E S P+ V L+ S +F + G PRP
Sbjct: 4052 KKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI 4111
Query: 543 WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
W + I +++ +D L I + D+G +TC KN+AG SS+ +L ++A
Sbjct: 4112 WTKDGKAITQGGKYKL-SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKA 4170
Score = 50.4 bits (115), Expect = 7e-05
Identities = 51/230 (22%), Positives = 89/230 (38%), Gaps = 12/230 (5%)
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE----PPQVIEPLKSMIVRQ 748
+V + N+ + E + V N GE+ + + T + + P E L+++ VR
Sbjct: 2109 TVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRY 2168
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTK-----SDGDTHSITILKPKKVKDEGVY 803
+ L +V G+P+P + W + K + A K G H + I+ D VY
Sbjct: 2169 QSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL-IIASVTDDDATVY 2227
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
++A N G +A + VE P + + P + + + + + P P
Sbjct: 2228 QVRATNQGGSVSGTASLEVEVPAKIHL--PKTLEGMGAVHALRGEVVSIKIPFSGKPDPV 2285
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
ITW + ++I + LV N D+G Y A N G
Sbjct: 2286 ITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 2335
Score = 47.2 bits (107), Expect = 6e-04
Identities = 47/207 (22%), Positives = 87/207 (42%), Gaps = 17/207 (8%)
Query: 697 ITNVKKFQEGTYTVVAVNREGE---ASLPIVLKIKTGEKEPPQVIEPL--KSMIVRQGES 751
+T++ + E + V+A N G A +P +K+ + P ++ + + VRQG
Sbjct: 1321 LTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGV 1380
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L+ + G P P W K + + + +TH+ ++K D G Y L EN
Sbjct: 1381 IRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKC 1440
Query: 812 GIAETSAVITVEEPTEENA-EPPLFINRFQEITVK-------EKGTIKLVARV-TRNPVP 862
G + + I V N+ E PL + Q +V+ + G ++ + R VP
Sbjct: 1441 G--KKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVP 1498
Query: 863 SITWYRNNEIISPSETITQNFDGENIE 889
WY + + + + + EN+E
Sbjct: 1499 KAAWYTIDSRVRGTSLVVKGLK-ENVE 1524
Score = 46.4 bits (105), Expect = 0.001
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 5/116 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFI--NRFQEITVKEKGTIKLVARVTRNP 860
+ + A N +G++E S I EP E P L + + + +T++ +++L+ V+ P
Sbjct: 642 FRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRP 701
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P ITW + ++ I E+ L+I + + D+G Y A N +GK S
Sbjct: 702 PPVITWSKQGIDLASRAIIDTT---ESYSLLIVDKVNRYDAGKYTIEAENQSGKKS 754
Score = 43.2 bits (97), Expect = 0.010
Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 499 EKPTSEE--QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDF 556
EK T+ + ++A + K R +G + +F C +G P P +TW R+ ++ S
Sbjct: 3775 EKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGRVLSTSARH 3834
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
Q+ +T I V D G ++ V +N+ G + L ++
Sbjct: 3835 QV-TTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ 3878
Score = 43.2 bits (97), Expect = 0.010
Identities = 18/66 (27%), Positives = 29/66 (43%)
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
+G P P V W + G L + +TT + S I ++ S Y++ N+ G
Sbjct: 3812 DGEPVPTVTWLRKGRVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEA 3871
Query: 1657 EVTLKV 1662
E TL +
Sbjct: 3872 EFTLTI 3877
Score = 42.7 bits (96), Expect = 0.014
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 520 HTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAG 579
H P G V+ + G P P +WF + ++ S+ + VA L IRE D G
Sbjct: 976 HVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVE-THTKVAKLTIRETTIRDTG 1034
Query: 580 TFTCVAKNAAGFASSTTELIV 600
+T KN G T ++I+
Sbjct: 1035 EYTLELKNVTGTTLETIKVII 1055
Score = 41.9 bits (94), Expect = 0.024
Identities = 24/79 (30%), Positives = 36/79 (45%), Gaps = 2/79 (2%)
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDT--HSITILKPKKVKDEGVY 803
+R G ++L A V G P P I W K +K + S T + ++K D G Y
Sbjct: 286 IRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKY 345
Query: 804 TLKAENSEGIAETSAVITV 822
TL +N+ G S ++ V
Sbjct: 346 TLTVKNASGTKAVSVMVKV 364
Score = 41.9 bits (94), Expect = 0.024
Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 5/123 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN-RFQE-ITVKEKGTIKLVARVTRNP 860
+ + A N+ G E + V + TE P ++ R+QE I V++ G I+L + P
Sbjct: 1332 FRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKP 1391
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
P W + + IS I + + ELVI D DSG Y V N GK + +
Sbjct: 1392 FPICKWTKEGQDISKRAMIATS--ETHTELVIKEADRG-DSGTYDLVLENKCGKKAVYIK 1448
Query: 921 VTI 923
V +
Sbjct: 1449 VRV 1451
Score = 40.3 bits (90), Expect = 0.074
Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATLVIREVFPEDAGTF 581
+G + C G P P++TW I + + + ++ D++ TL+I +V +D G +
Sbjct: 4569 EGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLY 4628
Query: 582 TCVAKNAAGFASSTTELIVEA 602
T N G S+T + + +
Sbjct: 4629 TLSLGNEFGSDSATVNIHIRS 4649
Score = 39.9 bits (89), Expect = 0.098
Identities = 50/230 (21%), Positives = 93/230 (40%), Gaps = 10/230 (4%)
Query: 702 KFQEGTYTVVA--VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI--VRQGESVILSAQ 757
++Q TY + A V++ EAS PI+ + P V + +S + + + ++
Sbjct: 137 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPGVTDVQRSTVSLIWSAPAYDGGSK 196
Query: 758 VVGN--PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN--SEGI 813
VVG R ++ + + +K T + ++T L + V A S+G
Sbjct: 197 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 256
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
T V +E AE ++ +T++ + L A V P P I W + ++ +
Sbjct: 257 ESTGPVTCRDEYAPPKAELDARLHG-DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL 315
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E ++ + G+ VI D DSG Y N++G + V +
Sbjct: 316 DLCEKVSLQYTGKRATAVIKFCDRS-DSGKYTLTVKNASGTKAVSVMVKV 364
Score = 39.1 bits (87), Expect = 0.17
Identities = 27/139 (19%), Positives = 60/139 (43%), Gaps = 6/139 (4%)
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
H++T L ++ ++ ++A+N +G++E +T + P + ++ + T+
Sbjct: 921 HTVTSLNEG---EQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHV 977
Query: 847 KG--TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDY 904
++LV + P P+ +W+ + SE +T + +L I D+G+Y
Sbjct: 978 PAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIR-DTGEY 1036
Query: 905 KCVASNSAGKSSHGARVTI 923
N G + +V I
Sbjct: 1037 TLELKNVTGTTLETIKVII 1055
Score = 38.7 bits (86), Expect = 0.23
Identities = 26/104 (25%), Positives = 43/104 (41%), Gaps = 1/104 (0%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +E + H G V + G P P ITW + +I + +Q+ + +
Sbjct: 2255 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVF 2314
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAPLSDHGSEMT 612
V +DAG + AKN G T EL + + P G +++
Sbjct: 2315 PNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVS 2358
Score = 38.3 bits (85), Expect = 0.30
Identities = 21/70 (30%), Positives = 34/70 (48%), Gaps = 3/70 (4%)
Query: 1592 VTAVIEG--IPPPEVIWYKNGNKLENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEAS 1648
+T V+E + EV WYK+G KL+ + + + + T ++I L S +Y E S
Sbjct: 3962 LTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEIS 4021
Query: 1649 NTAGTSSVEV 1658
GTS +
Sbjct: 4022 GEGGTSKTNL 4031
Score = 37.5 bits (83), Expect = 0.52
Identities = 17/73 (23%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKE--YNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
V G P PEV W G K+ + ++ ++I + + + I ++++ YT+ N
Sbjct: 4575 VACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 4634
Query: 1650 TAGTSSVEVTLKV 1662
G+ S V + +
Sbjct: 4635 EFGSDSATVNIHI 4647
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/81 (28%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS + + V G P P+I W + + + + Y AT VI+ D+G +T
Sbjct: 289 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKR-ATAVIKFCDRSDSGKYTL 347
Query: 584 VAKNAAGF-ASSTTELIVEAP 603
KNA+G A S ++++P
Sbjct: 348 TVKNASGTKAVSVMVKVLDSP 368
Score = 35.9 bits (79), Expect = 1.6
Identities = 14/53 (26%), Positives = 28/53 (52%)
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+V WY +LEN ++Y IT ++ +++ +K++ + Y + N G S
Sbjct: 2826 QVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDS 2878
Score = 35.5 bits (78), Expect = 2.1
Identities = 17/60 (28%), Positives = 28/60 (46%)
Query: 1132 KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTV 1191
K + + W K E+ + L GK+ I CD D+G+Y+ V N+ T ++V
Sbjct: 301 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 360
Score = 35.5 bits (78), Expect = 2.1
Identities = 17/54 (31%), Positives = 29/54 (53%)
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
WF GS+++ S + + K KL I + + D GEY+ E+ N T + T++
Sbjct: 999 WFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTLETIK 1052
Score = 35.5 bits (78), Expect = 2.1
Identities = 24/101 (23%), Positives = 39/101 (38%), Gaps = 1/101 (0%)
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
P I ++ K G L P P+ +W K + + + K S D ++ +LT+
Sbjct: 1760 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTV 1819
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-PPGKP 1387
E D G+Y N G + + + P PG P
Sbjct: 1820 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP 1860
Score = 35.5 bits (78), Expect = 2.1
Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 4/80 (5%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEI-NSETADVVWERDG-EIIKPKKNKYDFEKRGHIRKL 1074
P ++++D K + A L +I D+ W R G E+I+ +K K + R H L
Sbjct: 1760 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT--L 1817
Query: 1075 YIRNTSVHDEGEYSCILRDE 1094
+ DEG Y+CI +E
Sbjct: 1818 TVMTEEQEDEGVYTCIATNE 1837
Score = 35.1 bits (77), Expect = 2.8
Identities = 39/180 (21%), Positives = 74/180 (41%), Gaps = 17/180 (9%)
Query: 1218 VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
+E D++ VTWY +E++EK+ + + L ++ T+ D Y C +++
Sbjct: 2818 IENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGED 2877
Query: 1278 KLKVEV-VEFPPKIVDY---EREYRIKRGSDVTLLVDYQ---AFPQPNDEWIVNSKI--- 1327
E+ V+ ++ DY +IKR +D L++ P N V +
Sbjct: 2878 SSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFG 2937
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVEN-------TDAGIYKLRLENNCGHADVEMNVTILDK 1380
+ H +P + + IK +N +D G+Y+L + + D E V +K
Sbjct: 2938 VTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 2997
Score = 34.7 bits (76), Expect = 3.7
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 641 KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNV 700
K + G+ + L + P P I W +G ++ S AI Y S+L + V
Sbjct: 681 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLA-----SRAIIDTTESY-SLLIVDKV 734
Query: 701 KKFQEGTYTVVAVNREGEASLPIVLKI 727
++ G YT+ A N+ G+ S +++K+
Sbjct: 735 NRYDAGKYTIEAENQSGKKSATVLVKV 761
Score = 34.7 bits (76), Expect = 3.7
Identities = 24/90 (26%), Positives = 42/90 (46%), Gaps = 5/90 (5%)
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT---ILKPKK 796
P K++ V G V L + G P P +W ++ + +TH+ ++
Sbjct: 971 PQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRE-SERVTVETHTKVAKLTIRETT 1029
Query: 797 VKDEGVYTLKAENSEGIA-ETSAVITVEEP 825
++D G YTL+ +N G ET VI +++P
Sbjct: 1030 IRDTGEYTLELKNVTGTTLETIKVIILDKP 1059
Score = 33.9 bits (74), Expect = 6.4
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 3/72 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G++++ V G P P ITW +Q I S+ + ++ + L++ +V DAG +T
Sbjct: 688 GASLRLMVSVSGRPPPVITWSKQ-GIDLASR--AIIDTTESYSLLIVDKVNRYDAGKYTI 744
Query: 584 VAKNAAGFASST 595
A+N +G S+T
Sbjct: 745 EAENQSGKKSAT 756
Score = 33.5 bits (73), Expect = 8.5
Identities = 21/80 (26%), Positives = 42/80 (52%), Gaps = 4/80 (5%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
GSD++L+ + PEP I W KG++ + D V+++ +V+K + + G
Sbjct: 289 GSDLVLDAAVGGKPEPKIIWT-KGDKEL-DLCEKVSLQYTGKRATAVIKFCD--RSDSGK 344
Query: 708 YTVVAVNREGEASLPIVLKI 727
YT+ N G ++ +++K+
Sbjct: 345 YTLTVKNASGTKAVSVMVKV 364
Score = 33.5 bits (73), Expect = 8.5
Identities = 18/67 (26%), Positives = 27/67 (40%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
++ P EV WY NG +L+ + + T + I + S Y +N G S
Sbjct: 3624 VQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGERS 3683
Query: 1656 VEVTLKV 1662
TL V
Sbjct: 3684 DYATLDV 3690
>X64697-1|CAA45938.1| 3100|Homo sapiens titin protein.
Length = 3100
Score = 252 bits (617), Expect = 1e-65
Identities = 197/757 (26%), Positives = 325/757 (42%), Gaps = 35/757 (4%)
Query: 1218 VEIPDETLDVTWYK--KKSVIEDTEKFTLISDVK---KRTLIIRKCTEDDQCEYTCVLLD 1272
+E+ ++ D WY+ + I +TE FT + D+K K + + EY+ + +
Sbjct: 605 LEMQEKDTD-QWYRVHTNATIRNTE-FT-VPDLKMGQKYSFRVAAVNVKGMSEYSESIAE 661
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
+ ++++ +E D ++ I+ G+ + L+V P P W + + I
Sbjct: 662 IEPVERIEIPDLELAD---DLKKTVTIRAGASLRLMVSVSGRPPPVITW--SKQGIDLAS 716
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ L + KV DAG Y + EN G + V + D P P + E+
Sbjct: 717 RAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEV 776
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRF 1451
S+ I W+ P G + I Y+VE +E + +V +KT I L + + F
Sbjct: 777 SRDSVTITWEIPTIDGGAPINNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMHYF 836
Query: 1452 RAYAVNEVDISDASETTEYYKV----IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
R N I + ET++ V + K++ V K + E + + G
Sbjct: 837 RVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGY 896
Query: 1508 VPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE---TSCV 1564
V + K+ T K T ++ A N+ G E T
Sbjct: 897 VLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYL---FRIRAQNEKGVSEPRETVTA 953
Query: 1565 VGIQQK---PVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
V +Q P I +S K H G + I G PPP W+ G+KL +
Sbjct: 954 VTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVT 1013
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
+ T K + + I+E + +YT+E N GT+ + + + DKP P GP+ + EI
Sbjct: 1014 VETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTLETIKVIILDKPGPPTGPIKIDEIDA 1073
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD-VDRDVETYCIQKLNENCEYMF 1739
S+TI W+PP DGG L+ Y +E+ + W+ V++ V R T+ +L E EY+F
Sbjct: 1074 TSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTR--STFKFTRLTEGNEYVF 1131
Query: 1740 RVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPI 1799
RV A N G L+SE I ++++ +P + + + +TW+P E +GGS +
Sbjct: 1132 RVAATNRFGIGSYLQSEVIECRSSIRIPG-PPETLQIFDVSRDGMTLTWYPPEDDGGSQV 1190
Query: 1800 IDYKVEIKQ-EGKKWKXXXXXXXXXARIQK--LSINTTYQFRIYARNEIGTSLPYTSDDK 1856
Y VE K+ +W R + L+ Y+ R+ A N G+ P
Sbjct: 1191 TGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKP 1250
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
I + PP +P+N V+++T SV+L W+ PE GGS +T Y+IE + V WTK
Sbjct: 1251 IVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCN 1310
Query: 1917 TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
T + E+ + ++ + E FR+ A N G P E
Sbjct: 1311 TTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAE 1347
Score = 243 bits (594), Expect = 6e-63
Identities = 176/609 (28%), Positives = 276/609 (45%), Gaps = 30/609 (4%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
DKPS PG+ IL I S+ + W++PE G I+ Y VEY++ + W + + I
Sbjct: 1656 DKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDK 1715
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
Q +I L + Y FR +A NE +S T K K T ++P + K +K++TT+
Sbjct: 1716 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKT-KLTSGEAPGIRKEMKDVTTKLG 1774
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXXXXXXXXXXX-YKCIA 1552
E +L+C G P P + WYR GK+L + K + + R Y CIA
Sbjct: 1775 EAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA 1834
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIKQKH--KVGDEWLVTAVIEGIPPPEVIWYKNG 1610
N+ GEVETS + +Q P +K+K+ VG + + G P P + W+
Sbjct: 1835 TNEVGEVETSSKLLLQATPQFH-PGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQ 1893
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKR-SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP 1669
L+N + I E + + +K ++R +H+ KY ++ SN GT + +++ DKP KP
Sbjct: 1894 KLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKP 1953
Query: 1670 EGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQ 1729
GP+++ + + S I WKPP DDGG +T Y +EK E ++ V T I
Sbjct: 1954 TGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIV 2013
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW 1788
L EN Y FRV AQN G S+ LE S ++IK+ + P + +S + W
Sbjct: 2014 NLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPG-APGKPTITAVTKDSCVVAW 2072
Query: 1789 FPSEKNGGSPIIDYKVEIKQEGK--KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNE 1844
P +GG+ I +Y +E K+E K KW ++ L Y+FR+ N
Sbjct: 2073 KPPASDGGAKIRNYYLE-KREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENL 2131
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQP------RNFVVSESTSRSVTLKWTEPESNGGSPIT 1898
G S + IT K+ P P RN V ++ ++ K T PI
Sbjct: 2132 GGESEWSEISEPIT-PKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVT----GHPKPIV 2186
Query: 1899 NYIIEFKTVKGKSWT-KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
+ + K + +I G H+ I ++ + D ++++ A N G T S V
Sbjct: 2187 KWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 2246
Query: 1958 RLEKHATVP 1966
+ +P
Sbjct: 2247 EVPAKIHLP 2255
Score = 222 bits (542), Expect = 1e-56
Identities = 207/895 (23%), Positives = 362/895 (40%), Gaps = 51/895 (5%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKSVIEDTEKFTLISDVKKRT 1252
P+I+ + + I VPA L + I +W+ S + ++E+ T+ + K
Sbjct: 963 PTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAK 1022
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQ 1312
L IR+ T D EYT L + TT ++V+ K +I ++ + ++
Sbjct: 1023 LTIRETTIRDTGEYTLELKNVTGTTLETIKVIILD-KPGPPTGPIKIDEIDATSITISWE 1081
Query: 1313 AFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT---IKKVENTDAGIYKLRLE--NNCG 1367
P+ + ++ ++++ +P S S+T K T+ Y R+ N G
Sbjct: 1082 P-PELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFG 1140
Query: 1368 HADVEMNVTI-----LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI 1422
+ I + P PP I ++ + + W PE+ G S + Y+VE +E+
Sbjct: 1141 IGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEV 1200
Query: 1423 DTTEWISVKNITKTQTSIQN--LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ 1480
W+ V + T T ++ L Y R A+N S ++ ++ I
Sbjct: 1201 RADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSK--PIVAMDPIA 1258
Query: 1481 SP-TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR------DGKKLKTAKATYENRX 1533
P + P TT + + + + KVT Y D + T
Sbjct: 1259 PPGKPQNPRVTDTTRTSVSLAWS-VPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIR 1317
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVG-IQQKPVITISNEDIKQKH------KV 1586
++ +A N G E + V G ++ ++ + ++ +++ +
Sbjct: 1318 EYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQ 1377
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G +T I+G P P W K G + K I T E + + IKE R S Y +
Sbjct: 1378 GGVIRLTIPIKGKPFPICKWTKEGQDIS--KRAMIATSETHTELVIKEADRGDSGTYDLV 1435
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKH 1706
N G +V + ++V P+ PEGP+ +I SV + W+PP DDGG ++ Y +E+
Sbjct: 1436 LENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERR 1495
Query: 1707 EPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTALD 1765
E W + R + ++ L EN EY FRV A+N G S+ L+S EP+ KT L+
Sbjct: 1496 EVPKAAWYTIDSRVRGT-SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLN 1554
Query: 1766 VPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXX 1822
P + SV ++W + +GGS + Y +E K+
Sbjct: 1555 PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKVVRHNKTQITTT 1614
Query: 1823 XARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSV 1882
+ L + YQFRI A+N++G S + + + PSQP + + SV
Sbjct: 1615 MYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSV 1674
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
TL+W +PE +GG I Y +E++ +W K + I + E E FR+ A
Sbjct: 1675 TLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFA 1734
Query: 1943 ENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
EN G+S P + ++ ++ T P E++ V + + G A L
Sbjct: 1735 ENETGLSRPRRT-AMSIKTKLTSGEAPGIRKEMKDVTTKL-----------GEAAQLSCQ 1782
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
I R + W GK + + K+ + HT + + + G+ + ++E
Sbjct: 1783 IVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNE 1837
Score = 219 bits (534), Expect = 1e-55
Identities = 158/601 (26%), Positives = 279/601 (46%), Gaps = 37/601 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS- 1439
PS P +P + + +++++I W+EP + G S II Y VE +E +T W+ + + +
Sbjct: 68 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 127
Query: 1440 -IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP-------TVEKPLKNI 1491
+ L Y+FR YA+N +S ASE + ++ + + +P + I
Sbjct: 128 KVTGLVEGLEYQFRTYALNAAGVSKASEASR--PIMAQNPVDAPGRPGVTDVQRSTVSLI 185
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCI 1551
+ P D + + + V+ DG+ LK T + ++ +
Sbjct: 186 WSAPAYDGGSKVVGYIIERKPVSEVGDGRWLK-CNYTIVSDNFFTVTALSEGDTYEFRVL 244
Query: 1552 AFNDHGEV----ETSCVVGIQQKPVITISNEDIKQKH-----KVGDEWLVTAVIEGIPPP 1602
A N G + E++ V + + + D + + G + ++ A + G P P
Sbjct: 245 AKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEP 304
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++IW K +L+ ++ ++ K + IK RS S KYT+ N +GT +V V +KV
Sbjct: 305 KIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKV 364
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
D P P G + + +++E T+ W P +DGG E+T Y +E+ E W+ + + +
Sbjct: 365 LDSPG-PCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWV-IVEGECP 422
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+Y + +L +N EY+FRV A N G +ESEPIV + + +PS E
Sbjct: 423 TLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGT-GKE 481
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKW---KXXXXXXXXXARIQKLSINTTYQFR 1838
+ I W E +GG+ I +Y V+ ++ E +W ++ L YQFR
Sbjct: 482 HIIIQWTKPESDGGNEISNYLVDKREKESLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFR 541
Query: 1839 IYARNEIGTSLPYTSDDKITIGK---TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGS 1895
+ A N G S P + I+ + T PPS PR V ++T S++L WT+P +GG+
Sbjct: 542 VTAVNAAGNSEPSERSNFISCREPSYTPGPPSAPR---VVDTTKHSISLAWTKPMYDGGT 598
Query: 1896 PITNYIIEFKTVKGKSWTKIVTVGGSVH--EHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
I Y++E + W ++ T ++ E + ++K + FR++A N G+S +E
Sbjct: 599 DIVGYVLEMQEKDTDQWYRVHT-NATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSE 657
Query: 1954 S 1954
S
Sbjct: 658 S 658
Score = 219 bits (534), Expect = 1e-55
Identities = 171/693 (24%), Positives = 291/693 (41%), Gaps = 26/693 (3%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP P +++ SI++ W +P G + I+ YV+E QE DT +W V I T+
Sbjct: 569 PGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE 628
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPN 1496
++ +LK Y FR AVN +S+ SE+ + ++ +I + LK +T
Sbjct: 629 FTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAG 688
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFN 1554
+ L G P P +TW + G L + T E+ Y A N
Sbjct: 689 ASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAEN 748
Query: 1555 DHGEVETSCVVGIQQKP--VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
G+ + +V + P ++ +++ + V W + + G P I K
Sbjct: 749 QSGKKSATVLVKVYDTPGPCPSVKVKEVS-RDSVTITWEIPTIDGGAPINNYIVEKREAA 807
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+ K +TTK ++ RI L + + N G T P P
Sbjct: 808 MRAFK--TVTTKCSKTLYRISGLVEGTMHYFRVLPENIYGIGEPCETSDAVLVSEVPLVP 865
Query: 1673 VIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQK 1730
+ ++++ +VT+ W+ PL DGG LT Y +E + RW+KV + V + +
Sbjct: 866 AKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTS 925
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV-PSXXXXXXXXXXIDNESVYITWF 1789
LNE +Y+FR+ AQN G SE E+ V L V P+ I +
Sbjct: 926 LNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVEL 985
Query: 1790 PSEKNGGSPIID---YKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
G P + +E ++ I++ +I T ++ + +N G
Sbjct: 986 VIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTG 1045
Query: 1847 TSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT 1906
T+L K+ I PP+ P + E + S+T+ W PE +GG+P++ Y++E +
Sbjct: 1046 TTLETI---KVIILDKPGPPTGP--IKIDEIDATSITISWEPPELDGGAPLSGYVVEQRD 1100
Query: 1907 VKGKSWTKIV-TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATV 1965
W + +V S + + E +E +FR++A N G+ +S+ + +
Sbjct: 1101 AHRPGWLPVSESVTRSTFK--FTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRI 1158
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP L+I V + + +W PE DGG+ + GY + ++V W+ V KV V +
Sbjct: 1159 PGPPET-LQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTR 1217
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ L+E Y R+ A N G +P +P
Sbjct: 1218 YRSTGLTEGLEYEHRVTAINARGSGKPSRPSKP 1250
Score = 215 bits (524), Expect = 2e-54
Identities = 228/896 (25%), Positives = 369/896 (41%), Gaps = 72/896 (8%)
Query: 1204 EFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
+ + + A +D L + + + W K ++ EK +L K+ T +I+ C D
Sbjct: 282 DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSD 341
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE-- 1320
+YT + +A T + V V K++D S VT A+ P ++
Sbjct: 342 SGKYTLTVKNASGTKAVSVMV-----KVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGG 396
Query: 1321 -----WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA-DVEMN 1374
+IV + + + + S + ++ + I+++R N G VE
Sbjct: 397 AEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESE 456
Query: 1375 VTILDK----PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV 1430
+ PSPPG P + I I W +PE+ G + I Y+V+ +E ++ W V
Sbjct: 457 PIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKESLRWTRV 516
Query: 1431 KN---ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP----- 1482
+ T+ + +L Y+FR AVN S+ SE + + + + P
Sbjct: 517 NKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSERSNFISCREPSYTPGPPSAPR 576
Query: 1483 ---TVEKPLKNITTEPNEDIELTCIFGGV--PQPKVT--WYRDGKKLKTAKATYENRXXX 1535
T + + T+P D T I G V Q K T WYR AT N
Sbjct: 577 VVDTTKHSISLAWTKPMYDGG-TDIVGYVLEMQEKDTDQWYR-----VHTNATIRN-TEF 629
Query: 1536 XXXXXXXXXXXXYKCIAFNDHGEVETS-CVVGIQQKPVITISN----EDIKQKHKV--GD 1588
++ A N G E S + I+ I I + +D+K+ + G
Sbjct: 630 TVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGA 689
Query: 1589 EWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEAS 1648
+ + G PPP + W K G L + I T E S++ + ++ R + KYTIEA
Sbjct: 690 SLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLIVDKVNRYDAGKYTIEAE 747
Query: 1649 NTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
N +G S V +KVYD P P V ++E+SR+SVTI W+ P DGG + Y +EK E
Sbjct: 748 NQSGKKSATVLVKVYDTPG-PCPSVKVKEVSRDSVTITWEIPTIDGGAPINNYIVEKREA 806
Query: 1709 DNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPS 1768
R K Y I L E + FRV+ +N G E E+ V+ + +VP
Sbjct: 807 AM-RAFKTVTTKCSKTLYRISGLVEGTMHYFRVLPENIYGIGEPCETSDAVLVS--EVP- 862
Query: 1769 XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARIQ 1827
+ +V + W +GGS + Y +E + G ++W
Sbjct: 863 LVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHT 922
Query: 1828 KLSINT--TYQFRIYARNEIGTSLPYTSDDKITIGK-----TLTPPSQPRNFVVSESTSR 1880
S+N Y FRI A+NE G S P + +T+ T+ + P+ + R
Sbjct: 923 VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQK-TIHVPAGR 981
Query: 1881 SVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRI 1940
V L P + P ++ ++ +S V V + I +D + +
Sbjct: 982 PVEL--VIPIAGRPPPAASWFFAGSKLR-ESERVTVETHTKVAKLTIRETTIRDTGEYTL 1038
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
+N G +L T + + L+K P PPT P++I + + + SW PE DGGAPL G
Sbjct: 1039 ELKNVTGTTLET-IKVIILDK----PGPPTGPIKIDEIDATSITISWEPPELDGGAPLSG 1093
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
Y + RD + W+ V + V F L+E + Y+ R+ A N G+ L+S+
Sbjct: 1094 YVVEQRDAHRPGWLPVSE-SVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSE 1148
Score = 196 bits (479), Expect = 5e-49
Identities = 168/659 (25%), Positives = 291/659 (44%), Gaps = 41/659 (6%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVE 1192
++W++ G E+ S +++ DG+ L + + +D G Y+C EVG + ++ L ++
Sbjct: 1791 IKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ 1850
Query: 1193 E-PSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKK 1250
P + L E + L V + +TW+ + +++++E T+ +
Sbjct: 1851 ATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHY 1910
Query: 1251 RTLIIRKCTEDDQC-EYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
L+++ +Y L + T L VE+ + P K + + S V
Sbjct: 1911 THLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAV-- 1968
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPS---IDSKSASLTIKKVENT--DAGIY-KLR 1361
+ ++ WI N +++KC+ + + + S + S+T ++ N +AG Y ++
Sbjct: 1969 -ISWKPPADDGGSWITNY-VVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVS 2026
Query: 1362 LENNCGHAD-VEMNVTIL-----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
+N G +D +E++ ++ +KP PGKP I + S + W P + G + I Y
Sbjct: 2027 AQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNY 2086
Query: 1416 VVEYQEIDTTEWISV--KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
+E +E +WISV + I +T S++NL Y FR N S+ SE +E
Sbjct: 2087 YLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITP 2146
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRX 1533
+ IQ+P ++ L+N+ + L C G P+P V WYR GK++ Y +
Sbjct: 2147 KSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQE 2206
Query: 1534 XXXX------XXXXXXXXXXYKCIAFNDHGEVE--TSCVVGIQQKPVITISNEDIKQKHK 1585
Y+ A N G V S V + K + + E + H
Sbjct: 2207 FKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHA 2266
Query: 1586 V-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN-ITTKEKTSVIRIKELKRSHSSKY 1643
+ G+ + G P P + W K + ++N+ Y I T+ TS++ ++R + Y
Sbjct: 2267 LRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFY 2326
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAI 1703
+ A N G V L V D P P G V + + SR+SV + W P DGG ++T Y +
Sbjct: 2327 VVCAKNRFGIDQKTVELDVADVPDPPRG-VKVSDASRDSVNLTWTEPASDGGSKITNYIV 2385
Query: 1704 EKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIK 1761
EK RW++V R+ Y + L Y FRVIA+N G S+ E SEP + K
Sbjct: 2386 EKCATTAERWLRVGQA-RETR-YTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITK 2442
Score = 184 bits (448), Expect = 3e-45
Identities = 216/967 (22%), Positives = 388/967 (40%), Gaps = 83/967 (8%)
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLT 1217
G+K ++ ++ EYS + ++ + +E P + L + + + A L
Sbjct: 637 GQKYSFRVAAVNVKGMSEYSESI--AEIEPVERIEIPDLELADDLKKTVTIRAGASLRLM 694
Query: 1218 VEIPDETLDV-TWYKK------KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
V + V TW K+ +++I+ TE ++L LI+ K D +YT
Sbjct: 695 VSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL--------LIVDKVNRYDAGKYTIEA 746
Query: 1271 LD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
+ K + + V+V + P ++K S ++ + ++ P + +N+ I+
Sbjct: 747 ENQSGKKSATVLVKVYDTPGPCPSV----KVKEVSRDSVTITWE-IPTIDGGAPINNYIV 801
Query: 1329 KKCKHTKPSIDSKSA--SLTIKKVENTDAGI---YKLRLENNCG---HADVEMNVTILDK 1380
+K + + + + S T+ ++ G +++ EN G + V + +
Sbjct: 802 EKREAAMRAFKTVTTKCSKTLYRISGLVEGTMHYFRVLPENIYGIGEPCETSDAVLVSEV 861
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKT--QT 1438
P P K ++++ S++ + W++P G S + YV+E + T W+ V + T +
Sbjct: 862 PLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEH 921
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE---KPLKNITTEP 1495
++ +L Y FR A NE +S+ ET +++ ++ PT++ P K I
Sbjct: 922 TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV-TVQDLRV-LPTIDLSTMPQKTIHVPA 979
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFN 1554
+EL G P P +W+ G KL+ + + T E
Sbjct: 980 GRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRET--------TIR 1031
Query: 1555 DHGE--VETSCVVG--IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK-- 1608
D GE +E V G ++ VI + DE T++ PPE+
Sbjct: 1032 DTGEYTLELKNVTGTTLETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPL 1091
Query: 1609 NGNKLENDKEYN-----ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+G +E + ++ S + L + + + A+N G S + +
Sbjct: 1092 SGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIE 1151
Query: 1664 DK-----PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
+ P PE I ++SR+ +T+ W PP DDGG ++T Y +E+ E +RW++V
Sbjct: 1152 CRSSIRIPGPPETLQIF-DVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNK 1210
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXX 1777
V + Y L E EY RV A N G + + S+PIV + P
Sbjct: 1211 VPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPI-APPGKPQNPRVT 1269
Query: 1778 XIDNESVYITWFPSEKNGGSPIIDYKVEI-KQEGKKWKXXXXXXXXXAR--IQKLSINTT 1834
SV + W E GGS + Y +E+ K + +W + L
Sbjct: 1270 DTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAE 1329
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES--TSRSVTLKWTEPESN 1892
Y+FR+ A N G P + + + L P + E + ++ T P
Sbjct: 1330 YRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKG 1389
Query: 1893 GGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
PI + E + + ++ ++ + E I+ D + + EN G
Sbjct: 1390 KPFPICKWTKEGQDISKRA---MIATSETHTELVIKEADRGDSGTYDLVLENKCG----K 1442
Query: 1953 ESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM 2012
++ +++ + P+ P PLE + V SW P DGGA +LGY + R+V K
Sbjct: 1443 KAVYIKVRVIGS-PNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAA 1501
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEE 2072
W + V ++ L EN Y R+ A N+ G+S+PL+S+EP V P + E
Sbjct: 1502 WYTIDS-RVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEP--VTPKTPLNPPEP 1558
Query: 2073 PGEQTEV 2079
P EV
Sbjct: 1559 PSNPPEV 1565
Score = 153 bits (370), Expect = 9e-36
Identities = 112/414 (27%), Positives = 181/414 (43%), Gaps = 14/414 (3%)
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P KP+ P + + +R SV++ W P D+GG ++T Y IE + D + W K +
Sbjct: 1260 PGKPQNPRVT-DTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIRE 1318
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV-IKTALDVPSXXXXXXXXXXID-NES 1783
Y + L + EY FRV+A N G E E V + L+ P I +
Sbjct: 1319 YTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQG 1378
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
I K PI + E + K+ I++ + + + N
Sbjct: 1379 GVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLEN 1438
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
+ G Y K+ + + P P + + RSV + W P +GG+ I YI+E
Sbjct: 1439 KCGKKAVYI---KVRVIGSPNSPEGPLEY--DDIQVRSVRVSWRPPADDGGADILGYILE 1493
Query: 1904 FKTVKGKSWTKIVT-VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQS-VRLEK 1961
+ V +W I + V G+ ++ +KE E FR+SAEN G+S P +S+ V +
Sbjct: 1494 RREVPKAAWYTIDSRVRGT--SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKT 1551
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
P PP+ P E+ V + V SW P+ DGG+ + GY I ++ + + K +
Sbjct: 1552 PLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKVVRHNKTQI 1611
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
T + + L + Y RI A+N++GLSE + EP V+ + +PGE
Sbjct: 1612 TTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEP--VVCKDPFDKPSQPGE 1663
Score = 136 bits (328), Expect = 1e-30
Identities = 196/790 (24%), Positives = 318/790 (40%), Gaps = 70/790 (8%)
Query: 1214 AYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL- 1271
A L+ +I L D+ WY+ + + K+ + SD + TL + ++D+ YTC+
Sbjct: 1777 AQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATN 1836
Query: 1272 ---DAKSTTKLKVEVV-EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
+ ++++KL ++ +F P E+ Y GS + L V Y P P W K+
Sbjct: 1837 EVGEVETSSKLLLQATPQFHPGYPLKEKYYGAV-GSTLRLHVMYIGRPVPAMTWFHGQKL 1895
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVE-NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
++ ++ L +K V+ T AG YK++L N G D ++V I DKP P
Sbjct: 1896 LQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTG 1955
Query: 1387 PNILE-IDSSSINICWDEPENTGNSTIIYYVVEYQEI-DTTEWISVKN-ITKTQTSIQNL 1443
P ++E + +S I W P + G S I YVVE E + EW V + I+ T I NL
Sbjct: 1956 PIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNL 2015
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTC 1503
N+ Y FR A N ISD E + VI ++ + P P K T +D +C
Sbjct: 2016 TENAGYYFRVSAQNTFGISDPLEVSSV--VIIKSPFEKPGA--PGKPTITAVTKD---SC 2068
Query: 1504 IFGGVPQ-----PKVTWY----RDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIA 1552
+ P K+ Y R+ K+ K T E Y +
Sbjct: 2069 VVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKC 2128
Query: 1553 FNDHGEVETSCV-VGIQQKPVITISNEDIKQKHK---VGDEWLVTAV--IEGIPPPEVIW 1606
N GE E S + I K + I K++ + V + T V + G P P V W
Sbjct: 2129 ENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKW 2188
Query: 1607 YKNGNKLEND-KEYNITT-KEKTSVIRIKELKRSHSSKYTIEASNTAGTSS------VEV 1658
Y+ G ++ D +Y I K + I + ++ Y + A+N G+ S VEV
Sbjct: 2189 YRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEV 2248
Query: 1659 TLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
K++ P EG + + E V+I K P + + + DNN +V
Sbjct: 2249 PAKIH-LPKTLEGMGAVHALRGEVVSI--KIPFSGKPDPVITWQKGQDLIDNNGHYQVI- 2304
Query: 1719 VDRDVETYCIQKLNENCEYMFRVI-AQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXX 1777
V R + E + F V+ A+N G ++ + + + A DVP
Sbjct: 2305 VTRSFTSLVFPNGVERKDAGFYVVCAKNRFG----IDQKTVELDVA-DVPDPPRGVKVSD 2359
Query: 1778 XIDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWKXXXXXXXXXARIQKLSINTTYQ 1836
+SV +TW +GGS I +Y VE ++W + L T+YQ
Sbjct: 2360 A-SRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQ 2418
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
FR+ A N+ G S P + T+T + R E + + T+ +
Sbjct: 2419 FRVIAENKFGLSKPSEPSE-----PTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKE 2473
Query: 1897 I-TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQ 1955
+ Y+I +G+ G VH C+E +K + + + T V + E
Sbjct: 2474 LYEKYMIAEDLGRGEF--------GIVH-RCVETSSKKTYMAKFVKVKGTDQVLVKKEIS 2524
Query: 1956 SVRLEKHATV 1965
+ + +H +
Sbjct: 2525 ILNIARHRNI 2534
Score = 121 bits (292), Expect = 2e-26
Identities = 144/607 (23%), Positives = 240/607 (39%), Gaps = 44/607 (7%)
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAK-ATYENRXXXXXXXXXX----XXXXXYKCIAF 1553
+ L ++ G P P +TW+ K L+ ++ T EN YK
Sbjct: 1873 LRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLS 1932
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV--IWYKNG- 1610
N G V+ V IQ KP I+ K +AVI PP + W N
Sbjct: 1933 NVFGTVDAILDVEIQDKPDKPTGPIVIEALLKN------SAVISWKPPADDGGSWITNYV 1986
Query: 1611 -NKLENDK--EYNITTKE-KTSVIRIKELKRSHSSKYTIEASNTAG------TSSVEVTL 1660
K E + E+ + + + RI L + + + A NT G SSV +
Sbjct: 1987 VEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIK 2046
Query: 1661 KVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVD 1720
++KP P P I ++++S + WKPP DGG ++ Y +EK E N+WI V +
Sbjct: 2047 SPFEKPGAPGKPTITA-VTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEE 2105
Query: 1721 RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXI 1779
+ ++ L E EY FRV +N G SE E SEPI K+ + + +
Sbjct: 2106 IRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLN 2165
Query: 1780 DNESVYITWFPSEKNGGSPIIDYK---VEIKQEGKKWKXXXXXXXXXARI-QKLSINTTY 1835
T PI+ + EI +G K++ I ++ +
Sbjct: 2166 VRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDAT 2225
Query: 1836 QFRIYARNEIGTSLPYTSDDKITI-GKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
+++ A N+ G S+ T+ ++ + K P + V V++K P S
Sbjct: 2226 VYQVRATNQ-GGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI--PFSGKP 2282
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
P+ + + +++ ++ KD + + A+N G+ +
Sbjct: 2283 DPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI----DQ 2338
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
++V L+ A VP PP +++ + V +W P DGG+ + Y + T W+
Sbjct: 2339 KTVELDV-ADVPDPPRG-VKVSDASRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWL 2396
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP--FKVIPGEGSHADEE 2072
VG+ ++ + +L +Y R+ A N+ GLS+P E EP K + DEE
Sbjct: 2397 RVGQA--RETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITKEDKTRAMNYDEE 2454
Query: 2073 PGEQTEV 2079
E EV
Sbjct: 2455 VDETREV 2461
Score = 108 bits (259), Expect = 2e-22
Identities = 108/453 (23%), Positives = 188/453 (41%), Gaps = 31/453 (6%)
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV-----YDKPSKPEGPVIM 1675
+ + K + I++ L + + + + N G S + + + PS P P +
Sbjct: 18 VNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVY 77
Query: 1676 REISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENC 1735
+S +++I W+ P DGG ++ Y +EK E + W+K V Y + L E
Sbjct: 78 H-VSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGL 136
Query: 1736 EYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKN 1794
EY FR A N G S+A E S PI+ + +D P + +V + W +
Sbjct: 137 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPG----RPGVTDVQRSTVSLIWSAPAYD 192
Query: 1795 GGSPIIDYKVEIKQEGK----KWK--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGT- 1847
GGS ++ Y +E K + +W + LS TY+FR+ A+N G
Sbjct: 193 GGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVI 252
Query: 1848 SLPYTSDDKITIGKTLTPPSQPRNF-VVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT 1906
S S +T PP + + + + + GG P II K
Sbjct: 253 SKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPK-IIWTKG 311
Query: 1907 VKGKSWTKIVTV--GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHAT 1964
K + V++ G I+ D + ++ +N G T++ SV ++
Sbjct: 312 DKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASG----TKAVSVMVK---V 364
Query: 1965 VPSP-PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
+ SP P L + V +W P+ DGGA + Y + R+ ++ W+ V + + T
Sbjct: 365 LDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIV-EGECPT 423
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
L + + L +N+ Y+ R+ A N+ G P+ES+
Sbjct: 424 LSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESE 456
Score = 99.1 bits (236), Expect = 2e-19
Identities = 77/300 (25%), Positives = 135/300 (45%), Gaps = 19/300 (6%)
Query: 523 DGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G V++ C++E Y + Q+TW+ ++ S+ +++ Y+D VA L ++++ D GT+
Sbjct: 2808 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYED-GVAILYVKDITKLDDGTY 2866
Query: 582 TCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
C N G SS EL V+ + D+ T+ +LE PP F+
Sbjct: 2867 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMR---LLER-PPEFTLP 2922
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHMYCSVLKIT 698
+ G ++ + PEP + W G++I P D + ESD +Y L I
Sbjct: 2923 LYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLY--QLTIN 2980
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV-----RQGESVI 753
+V + YTVVA N+ GE S L + + P+ ++ ++G+SV
Sbjct: 2981 SVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVC 3040
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYTLKAENS 810
+V G P PT+ W K+ +P+ P +G + ++ +D G Y + A N+
Sbjct: 3041 FEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNT 3100
Score = 95.5 bits (227), Expect = 2e-18
Identities = 60/204 (29%), Positives = 102/204 (50%), Gaps = 10/204 (4%)
Query: 713 VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN 772
++R ++ I K+ +GE P + + +K + + GE+ LS Q+VG P P I W +
Sbjct: 1740 LSRPRRTAMSIKTKLTSGEA--PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFG 1797
Query: 773 KPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
K + + SDG TH++T++ ++ +DEGVYT A N G ETS+ + ++ + +
Sbjct: 1798 KELIQSRKYKMSSDGRTHTLTVMTEEQ-EDEGVYTCIATNEVGEVETSSKLLLQATPQFH 1856
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE 889
PL + + T++L PVP++TW+ +++ SE IT
Sbjct: 1857 PGYPLKEKYYGAVG----STLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTH 1912
Query: 890 LVITNVDSEIDSGDYKCVASNSAG 913
LV+ NV + +G YK SN G
Sbjct: 1913 LVMKNVQRKTHAGKYKVQLSNVFG 1936
Score = 92.3 bits (219), Expect = 2e-17
Identities = 73/265 (27%), Positives = 115/265 (43%), Gaps = 12/265 (4%)
Query: 1801 DYKVEIKQEGKK-WKXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKIT 1858
+Y VE ++ G W+ ++ L+ Y FR+ + N G S P S I
Sbjct: 2 NYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAP-II 60
Query: 1859 IGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV 1918
PPS P V ++ +++++W EP +GGS I Y +E K W K V
Sbjct: 61 AEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKV 120
Query: 1919 GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRM 1977
+ + + E E FR A N GVS +E S+ + + P P +
Sbjct: 121 PCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRP----GVTD 176
Query: 1978 VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKT---MWMEVGKVDVNTLKFNIRDLSEN 2034
V + V W P +DGG+ ++GY I + V++ W++ V+ F + LSE
Sbjct: 177 VQRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEG 236
Query: 2035 HTYMIRIYARNEIG-LSEPLESDEP 2058
TY R+ A+N G +S+ ES P
Sbjct: 237 DTYEFRVLAKNAAGVISKGSESTGP 261
Score = 61.7 bits (143), Expect = 3e-08
Identities = 82/345 (23%), Positives = 146/345 (42%), Gaps = 28/345 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F ++ + V S+ L C++ P+P + W +G+EI+ D + I+ Y
Sbjct: 2155 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIAD-GLKYRIQEFKGGYHQ 2213
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK-EPPQVIEPLKSMIVRQGESV 752
++ I +V Y V A N+ G S L+++ K P+ +E + ++ +GE V
Sbjct: 2214 LI-IASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVV 2272
Query: 753 ILSAQVVGNPRPTITWCK------NNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ G P P ITW K NN + + T+S S+ + KD G Y +
Sbjct: 2273 SIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRS---FTSLVFPNGVERKDAGFYVVC 2329
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLV-ARVTRNPVPSIT 865
A+N GI + TVE + +PP R +++ + ++ L + IT
Sbjct: 2330 AKNRFGIDQK----TVELDVADVPDPP----RGVKVSDASRDSVNLTWTEPASDGGSKIT 2381
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTI 923
Y + + +E + + N+ + S ++ +A N G K S + TI
Sbjct: 2382 NYIVEKCATTAERWLRVGQARETRYTVINLFGK-TSYQFRVIAENKFGLSKPSEPSEPTI 2440
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEIS 968
E T + + E +E + V + + SH+ STK + K I+
Sbjct: 2441 TKEDKT--RAMNYDEEVDETREVSM-TKASHS-STKELYEKYMIA 2481
Score = 60.9 bits (141), Expect = 5e-08
Identities = 60/235 (25%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++++ T G Q CQ+ G P P I W+R + S+ ++M D TL
Sbjct: 1759 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKM-SSDGRTHTL 1817
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
+ ED G +TC+A N G ++++L+++A H
Sbjct: 1818 TVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFH--------------------- 1856
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
P + K K Y GS + L + P P + W F G++++ + ++ IE+
Sbjct: 1857 -----PGYPLKEK-YYGAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQNSE-NITIENTE 1908
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPL 741
H V+K +K G Y V N G +A L + ++ K + P VIE L
Sbjct: 1909 HYTHLVMKNVQ-RKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEAL 1962
Score = 60.5 bits (140), Expect = 6e-08
Identities = 48/209 (22%), Positives = 84/209 (40%), Gaps = 10/209 (4%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ G P K+ K G L C++V P PDI W G+E++ ++ +
Sbjct: 1754 LTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGR 1813
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV- 746
H L + ++ EG YT +A N GE L ++ + P PLK
Sbjct: 1814 TH----TLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGY--PLKEKYYG 1867
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDE---GVY 803
G ++ L +G P P +TW K ++ + +T T L K V+ + G Y
Sbjct: 1868 AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKY 1927
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEP 832
++ N G + + +++ ++ P
Sbjct: 1928 KVQLSNVFGTVDAILDVEIQDKPDKPTGP 1956
Score = 59.7 bits (138), Expect = 1e-07
Identities = 62/299 (20%), Positives = 117/299 (39%), Gaps = 38/299 (12%)
Query: 646 DEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+EG + C++ + + W F ++ E + E + ++L + ++ K
Sbjct: 2807 EEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGV----AILYVKDITKLD 2862
Query: 705 EGTYTVVAVNREGEASLPIVLKIK------------TGEK------------EPPQVIEP 740
+GTY VN GE S L +K T +K PP+ P
Sbjct: 2863 DGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLP 2922
Query: 741 LKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV------KALPTKSDGDTHSITILKP 794
L + GE+V + +P P +TW K+ + + K +SD + +TI
Sbjct: 2923 LYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTI-NS 2981
Query: 795 KKVKDEGVYTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKL 852
D+ YT+ A N E + +T+ P ++ P+F +E ++
Sbjct: 2982 VTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCF 3041
Query: 853 VARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNS 911
RV+ P P++ W ++ + +S I +G + + D+G Y+ A+N+
Sbjct: 3042 EIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNT 3100
Score = 57.2 bits (132), Expect = 6e-07
Identities = 43/153 (28%), Positives = 71/153 (46%), Gaps = 16/153 (10%)
Query: 1047 VVWERDGEIIKPKKN--KYDFEKRGHIRKLYIRNTSVHDEGEYSCILR----DESCTAEV 1100
V W + G+ IKP N KY FE + +L I + + D+ EY+ + R ++SC A++
Sbjct: 2948 VTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKL 3007
Query: 1101 TVVELPPEIITRLQ--------NQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNH 1151
TV PP + L+ N + +G FEI ++ ++W KDG + +
Sbjct: 3008 TVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPN 3067
Query: 1152 IQLTIDG-KKQKLKIYDCDLDDAGEYSCEVGNS 1183
I++ +G L I D +D G Y N+
Sbjct: 3068 IEIIHEGLDYYALHIRDTLPEDTGYYRVTATNT 3100
Score = 56.0 bits (129), Expect = 1e-06
Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 1/108 (0%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMY 559
P S+ AP F E+LR + S C+V G+P+P + W+RQ II +++
Sbjct: 2146 PKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQ 2205
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDH 607
L+I V +DA + A N G S T L VE P H
Sbjct: 2206 EFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIH 2253
Score = 55.6 bits (128), Expect = 2e-06
Identities = 58/237 (24%), Positives = 89/237 (37%), Gaps = 34/237 (14%)
Query: 480 YTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRP 539
Y + KK+ + D + + E+P P F L K G V+F + +P P
Sbjct: 2895 YCRRTMKKIKRRTDTMRLLERP--------PEFTLPLYNKTAYVGENVRFGVTITVHPEP 2946
Query: 540 QITWFRQTAIIKPSQDFQMY--YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTE 597
+TW++ IKP + + Y D + L I V +D +T VA+N G S +
Sbjct: 2947 HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAK 3006
Query: 598 LIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
L V L ++ T + P F + EG + E R+
Sbjct: 3007 LTV--TLHPPPTDST-------------------LRPMFKRLLANAECQEGQSVCFEIRV 3045
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVN 714
IP P + W G+ + NI + I + Y L I + G Y V A N
Sbjct: 3046 SGIPPPTLKWEKDGQPLSLGPNIEI-IHEGLDYY--ALHIRDTLPEDTGYYRVTATN 3099
Score = 52.8 bits (121), Expect = 1e-05
Identities = 35/169 (20%), Positives = 68/169 (40%), Gaps = 4/169 (2%)
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
AEN G++ + + E P +++T K +L ++ P+P I W
Sbjct: 1734 AENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKW 1793
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
YR + + S + DG L + + E D G Y C+A+N G+ +++ +
Sbjct: 1794 YRFGKELIQSRKYKMSSDGRTHTLTVMTEEQE-DEGVYTCIATNEVGEVETSSKLLLQAT 1852
Query: 927 KVTFVKH-LQKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDH 972
+ L++ Y G T+ L + W+H +K + ++
Sbjct: 1853 PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSEN 1901
Score = 52.0 bits (119), Expect = 2e-05
Identities = 36/131 (27%), Positives = 66/131 (50%), Gaps = 5/131 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLP-IVLKIKTGEK-EPP--QVIEPLKSMI-VRQGES 751
+ ++K Q+ ++ V AVN +G + + +I+ E+ E P ++ + LK + +R G S
Sbjct: 631 VPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGAS 690
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L V G P P ITW K + + +++S+ I+ D G YT++AEN
Sbjct: 691 LRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQS 750
Query: 812 GIAETSAVITV 822
G + ++ V
Sbjct: 751 GKKSATVLVKV 761
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/114 (26%), Positives = 50/114 (43%), Gaps = 2/114 (1%)
Query: 476 DENNYTQYLQKKLNEKI--DKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQV 533
D+ YT + K E KL V P + ++ P+F L +G +V FE +V
Sbjct: 2986 DDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRV 3045
Query: 534 EGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
G P P + W + + + ++ ++ + L IR+ PED G + A N
Sbjct: 3046 SGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATN 3099
Score = 50.4 bits (115), Expect = 7e-05
Identities = 51/230 (22%), Positives = 89/230 (38%), Gaps = 12/230 (5%)
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE----PPQVIEPLKSMIVRQ 748
+V + N+ + E + V N GE+ + + T + + P E L+++ VR
Sbjct: 2109 TVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRY 2168
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTK-----SDGDTHSITILKPKKVKDEGVY 803
+ L +V G+P+P + W + K + A K G H + I+ D VY
Sbjct: 2169 QSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL-IIASVTDDDATVY 2227
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
++A N G +A + VE P + + P + + + + + P P
Sbjct: 2228 QVRATNQGGSVSGTASLEVEVPAKIHL--PKTLEGMGAVHALRGEVVSIKIPFSGKPDPV 2285
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
ITW + ++I + LV N D+G Y A N G
Sbjct: 2286 ITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFG 2335
Score = 49.2 bits (112), Expect = 2e-04
Identities = 60/263 (22%), Positives = 101/263 (38%), Gaps = 31/263 (11%)
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSY-RFRAYAVNEVDISDASETTEYY-- 1471
Y + Y+ D + VK+ITK K + Y +YA E+ + E +YY
Sbjct: 2842 YEITYE--DGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYA--ELFVKGVREVYDYYCR 2897
Query: 1472 KVIKETKIQSPTVEK---------PLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ +K+ K ++ T+ PL N T E++ P+P VTWY+ G+K+
Sbjct: 2898 RTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKI 2957
Query: 1523 KTA----KATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGE--VETSCVVGIQQKPVI 1573
K K T+E+ Y +A N +GE + V + P
Sbjct: 2958 KPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTD 3017
Query: 1574 TISNEDIKQ-----KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KT 1627
+ K+ + + G + GIPPP + W K+G L I +
Sbjct: 3018 STLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDY 3077
Query: 1628 SVIRIKELKRSHSSKYTIEASNT 1650
+ I++ + Y + A+NT
Sbjct: 3078 YALHIRDTLPEDTGYYRVTATNT 3100
Score = 47.2 bits (107), Expect = 6e-04
Identities = 47/207 (22%), Positives = 87/207 (42%), Gaps = 17/207 (8%)
Query: 697 ITNVKKFQEGTYTVVAVNREGE---ASLPIVLKIKTGEKEPPQVIEPL--KSMIVRQGES 751
+T++ + E + V+A N G A +P +K+ + P ++ + + VRQG
Sbjct: 1321 LTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGV 1380
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ L+ + G P P W K + + + +TH+ ++K D G Y L EN
Sbjct: 1381 IRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKC 1440
Query: 812 GIAETSAVITVEEPTEENA-EPPLFINRFQEITVK-------EKGTIKLVARV-TRNPVP 862
G + + I V N+ E PL + Q +V+ + G ++ + R VP
Sbjct: 1441 G--KKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERREVP 1498
Query: 863 SITWYRNNEIISPSETITQNFDGENIE 889
WY + + + + + EN+E
Sbjct: 1499 KAAWYTIDSRVRGTSLVVKGLK-ENVE 1524
Score = 46.4 bits (105), Expect = 0.001
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 5/116 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFI--NRFQEITVKEKGTIKLVARVTRNP 860
+ + A N +G++E S I EP E P L + + + +T++ +++L+ V+ P
Sbjct: 642 FRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRP 701
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P ITW + ++ I E+ L+I + + D+G Y A N +GK S
Sbjct: 702 PPVITWSKQGIDLASRAIIDTT---ESYSLLIVDKVNRYDAGKYTIEAENQSGKKS 754
Score = 43.6 bits (98), Expect = 0.008
Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKL---ENDKEYNITTKEKTSVIRIKELKRSHSSK 1642
VG+ I P P V WYK+G K+ +NDK+Y + + + I + ++
Sbjct: 2930 VGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAE 2989
Query: 1643 YTIEASNTAGTSSVEVTLKV 1662
YT+ A N G S + L V
Sbjct: 2990 YTVVARNKYGEDSCKAKLTV 3009
Score = 42.7 bits (96), Expect = 0.014
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 520 HTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAG 579
H P G V+ + G P P +WF + ++ S+ + VA L IRE D G
Sbjct: 976 HVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVE-THTKVAKLTIRETTIRDTG 1034
Query: 580 TFTCVAKNAAGFASSTTELIV 600
+T KN G T ++I+
Sbjct: 1035 EYTLELKNVTGTTLETIKVII 1055
Score = 41.9 bits (94), Expect = 0.024
Identities = 24/79 (30%), Positives = 36/79 (45%), Gaps = 2/79 (2%)
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDT--HSITILKPKKVKDEGVY 803
+R G ++L A V G P P I W K +K + S T + ++K D G Y
Sbjct: 286 IRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKY 345
Query: 804 TLKAENSEGIAETSAVITV 822
TL +N+ G S ++ V
Sbjct: 346 TLTVKNASGTKAVSVMVKV 364
Score = 41.9 bits (94), Expect = 0.024
Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 5/123 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN-RFQE-ITVKEKGTIKLVARVTRNP 860
+ + A N+ G E + V + TE P ++ R+QE I V++ G I+L + P
Sbjct: 1332 FRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKP 1391
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
P W + + IS I + + ELVI D DSG Y V N GK + +
Sbjct: 1392 FPICKWTKEGQDISKRAMIATS--ETHTELVIKEADRG-DSGTYDLVLENKCGKKAVYIK 1448
Query: 921 VTI 923
V +
Sbjct: 1449 VRV 1451
Score = 39.9 bits (89), Expect = 0.098
Identities = 50/230 (21%), Positives = 93/230 (40%), Gaps = 10/230 (4%)
Query: 702 KFQEGTYTVVA--VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI--VRQGESVILSAQ 757
++Q TY + A V++ EAS PI+ + P V + +S + + + ++
Sbjct: 137 EYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPGVTDVQRSTVSLIWSAPAYDGGSK 196
Query: 758 VVGN--PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN--SEGI 813
VVG R ++ + + +K T + ++T L + V A S+G
Sbjct: 197 VVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGS 256
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
T V +E AE ++ +T++ + L A V P P I W + ++ +
Sbjct: 257 ESTGPVTCRDEYAPPKAELDARLHG-DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL 315
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E ++ + G+ VI D DSG Y N++G + V +
Sbjct: 316 DLCEKVSLQYTGKRATAVIKFCDRS-DSGKYTLTVKNASGTKAVSVMVKV 364
Score = 39.1 bits (87), Expect = 0.17
Identities = 27/139 (19%), Positives = 60/139 (43%), Gaps = 6/139 (4%)
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
H++T L ++ ++ ++A+N +G++E +T + P + ++ + T+
Sbjct: 921 HTVTSLNEG---EQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHV 977
Query: 847 KG--TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDY 904
++LV + P P+ +W+ + SE +T + +L I D+G+Y
Sbjct: 978 PAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIR-DTGEY 1036
Query: 905 KCVASNSAGKSSHGARVTI 923
N G + +V I
Sbjct: 1037 TLELKNVTGTTLETIKVII 1055
Score = 38.7 bits (86), Expect = 0.23
Identities = 26/104 (25%), Positives = 43/104 (41%), Gaps = 1/104 (0%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +E + H G V + G P P ITW + +I + +Q+ + +
Sbjct: 2255 PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVF 2314
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAPLSDHGSEMT 612
V +DAG + AKN G T EL + + P G +++
Sbjct: 2315 PNGVERKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVS 2358
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/81 (28%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS + + V G P P+I W + + + + Y AT VI+ D+G +T
Sbjct: 289 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKR-ATAVIKFCDRSDSGKYTL 347
Query: 584 VAKNAAGF-ASSTTELIVEAP 603
KNA+G A S ++++P
Sbjct: 348 TVKNASGTKAVSVMVKVLDSP 368
Score = 35.9 bits (79), Expect = 1.6
Identities = 14/53 (26%), Positives = 28/53 (52%)
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+V WY +LEN ++Y IT ++ +++ +K++ + Y + N G S
Sbjct: 2826 QVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDS 2878
Score = 35.5 bits (78), Expect = 2.1
Identities = 17/60 (28%), Positives = 28/60 (46%)
Query: 1132 KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTV 1191
K + + W K E+ + L GK+ I CD D+G+Y+ V N+ T ++V
Sbjct: 301 KPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSV 360
Score = 35.5 bits (78), Expect = 2.1
Identities = 17/54 (31%), Positives = 29/54 (53%)
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
WF GS+++ S + + K KL I + + D GEY+ E+ N T + T++
Sbjct: 999 WFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTLETIK 1052
Score = 35.5 bits (78), Expect = 2.1
Identities = 24/101 (23%), Positives = 39/101 (38%), Gaps = 1/101 (0%)
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
P I ++ K G L P P+ +W K + + + K S D ++ +LT+
Sbjct: 1760 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTV 1819
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-PPGKP 1387
E D G+Y N G + + + P PG P
Sbjct: 1820 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYP 1860
Score = 35.5 bits (78), Expect = 2.1
Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 4/80 (5%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEI-NSETADVVWERDG-EIIKPKKNKYDFEKRGHIRKL 1074
P ++++D K + A L +I D+ W R G E+I+ +K K + R H L
Sbjct: 1760 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT--L 1817
Query: 1075 YIRNTSVHDEGEYSCILRDE 1094
+ DEG Y+CI +E
Sbjct: 1818 TVMTEEQEDEGVYTCIATNE 1837
Score = 35.1 bits (77), Expect = 2.8
Identities = 39/180 (21%), Positives = 74/180 (41%), Gaps = 17/180 (9%)
Query: 1218 VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
+E D++ VTWY +E++EK+ + + L ++ T+ D Y C +++
Sbjct: 2818 IENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGED 2877
Query: 1278 KLKVEV-VEFPPKIVDY---EREYRIKRGSDVTLLVDYQ---AFPQPNDEWIVNSKI--- 1327
E+ V+ ++ DY +IKR +D L++ P N V +
Sbjct: 2878 SSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFG 2937
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVEN-------TDAGIYKLRLENNCGHADVEMNVTILDK 1380
+ H +P + + IK +N +D G+Y+L + + D E V +K
Sbjct: 2938 VTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 2997
Score = 34.7 bits (76), Expect = 3.7
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 641 KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNV 700
K + G+ + L + P P I W +G ++ S AI Y S+L + V
Sbjct: 681 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLA-----SRAIIDTTESY-SLLIVDKV 734
Query: 701 KKFQEGTYTVVAVNREGEASLPIVLKI 727
++ G YT+ A N+ G+ S +++K+
Sbjct: 735 NRYDAGKYTIEAENQSGKKSATVLVKV 761
Score = 34.7 bits (76), Expect = 3.7
Identities = 24/90 (26%), Positives = 42/90 (46%), Gaps = 5/90 (5%)
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT---ILKPKK 796
P K++ V G V L + G P P +W ++ + +TH+ ++
Sbjct: 971 PQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRE-SERVTVETHTKVAKLTIRETT 1029
Query: 797 VKDEGVYTLKAENSEGIA-ETSAVITVEEP 825
++D G YTL+ +N G ET VI +++P
Sbjct: 1030 IRDTGEYTLELKNVTGTTLETIKVIILDKP 1059
Score = 33.9 bits (74), Expect = 6.4
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 3/72 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G++++ V G P P ITW +Q I S+ + ++ + L++ +V DAG +T
Sbjct: 688 GASLRLMVSVSGRPPPVITWSKQ-GIDLASR--AIIDTTESYSLLIVDKVNRYDAGKYTI 744
Query: 584 VAKNAAGFASST 595
A+N +G S+T
Sbjct: 745 EAENQSGKKSAT 756
Score = 33.5 bits (73), Expect = 8.5
Identities = 21/80 (26%), Positives = 42/80 (52%), Gaps = 4/80 (5%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
GSD++L+ + PEP I W KG++ + D V+++ +V+K + + G
Sbjct: 289 GSDLVLDAAVGGKPEPKIIWT-KGDKEL-DLCEKVSLQYTGKRATAVIKFCD--RSDSGK 344
Query: 708 YTVVAVNREGEASLPIVLKI 727
YT+ N G ++ +++K+
Sbjct: 345 YTLTVKNASGTKAVSVMVKV 364
>X73114-1|CAA51545.1| 1123|Homo sapiens slow MyBP-C protein.
Length = 1123
Score = 238 bits (582), Expect = 2e-61
Identities = 185/735 (25%), Positives = 325/735 (44%), Gaps = 32/735 (4%)
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
VE+ +V W ++G+ I+P KY FE +G R L+I N + D+ EY DE C+
Sbjct: 274 VELADPKLEVKWYKNGQEIRPS-TKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCS 332
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEI--QFSNHIQLT 1155
E+ V E P + +L++ G + E E+++ DA V+WFK+G EI + ++
Sbjct: 333 TELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIR 392
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAY 1215
++GKK L I DA EYS + +A L+V+ + L + V +
Sbjct: 393 VEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTD-QTVNLGKEIC 451
Query: 1216 LTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
L EI E + W K ++++++ ++ + L+I +D+ +Y
Sbjct: 452 LKCEI-SENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNV 510
Query: 1276 TTKLKVEVVEFPPKIV----DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKK 1330
T KV V++ PPKI+ D + + G+ + L + P P W K I++
Sbjct: 511 TLPAKVHVID-PPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEG 569
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
+ S++L I E D+G+Y + L+N G A + V ++D P PP P +
Sbjct: 570 SGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVT 629
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLK--TNSS 1448
E+ + W+ P G S I+ Y +E ++ ++ W+ + +T+ + K +
Sbjct: 630 EVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVA 689
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQS-PTVEKPLKNITT---EPNEDIELTCI 1504
Y R +AVN + IS S + + + T + TV+ T P + I +
Sbjct: 690 YEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGL 749
Query: 1505 FGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETS-- 1562
G V + + + A ++ + A N G E
Sbjct: 750 DGYVLE---YCFEGTEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYY 806
Query: 1563 ----CVVGIQQKPVITISNEDIKQKH--KVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
V I + P I I +KQ + +VG+ + +G P PE+ W K+G +++ +
Sbjct: 807 SQPILVKEIIEPPKIRIPRH-LKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKN 865
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
+ NI E ++I I++ +RSHS KY ++ + + +++ D+P P+ V +
Sbjct: 866 -QINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQ-IVKIE 923
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCE 1736
++ E+V + W PP DDG +T Y I+K + + W V + I +L E
Sbjct: 924 DVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSA-TITELVIGNE 982
Query: 1737 YMFRVIAQNPVGFSE 1751
Y FRV ++N G SE
Sbjct: 983 YYFRVFSENMCGLSE 997
Score = 132 bits (318), Expect = 2e-29
Identities = 147/629 (23%), Positives = 267/629 (42%), Gaps = 30/629 (4%)
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXX 984
+ F K L +Y+ ++G V + + + KWY N +EI +G
Sbjct: 250 KSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRIL 309
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D D++ ST L V+E ++L+D + LE E++ +
Sbjct: 310 FINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDD 369
Query: 1045 ADVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
A+V W ++G EII K++Y G L I + D EYS + +A+++V
Sbjct: 370 ANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVD 429
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
P +I+T L +Q VN G + + E+++ + +W K+G +Q S+ +++ G+ KL
Sbjct: 430 LKPLKILTPLTDQTVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKL 488
Query: 1164 KIYDCDLDDAGEY--SCEVGNSKCTA-ILTVEEPSINFT-LRLPEFILVPANTDAYLTVE 1219
I + +D G+Y + + N A + ++ P I L + V A L +
Sbjct: 489 VIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIP 548
Query: 1220 IPDETLDVTWYKK--KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKS 1275
I E + + K+++E + + S TL+I DD Y L + ++
Sbjct: 549 ISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEA 608
Query: 1276 TTKLKVEVVEFP-PKIVDYEREYRIKRGSDVTLL-VDYQAFP--QPNDEWIVNSKIIKKC 1331
+KV+VV+FP P + E G D ++ + A+ P + + K +
Sbjct: 609 HASIKVKVVDFPDPPVAPTVTEV----GDDWCIMNWEPPAYDGGSPILGYFIERKKKQSS 664
Query: 1332 KHTKPSID-SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
+ + + D K + KK+ A ++ N G + M + P +L
Sbjct: 665 RWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLL 724
Query: 1391 EIDS---SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKT 1445
+DS +++ + W P++ G + + YV+EY T +WI I KT+ +I L T
Sbjct: 725 TVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWIVANKDLIDKTKFTITGLPT 784
Query: 1446 NSSYRFRAYAVNEVDISDA---SETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
++ R AVN S+ S+ ++I+ KI+ P K + E + L
Sbjct: 785 DAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLK--QTYIRRVGEAVNLV 842
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
F G P+P++TW +DG ++ + N
Sbjct: 843 IPFQGKPRPELTWKKDGAEIDKNQINIRN 871
Score = 119 bits (287), Expect = 1e-25
Identities = 167/792 (21%), Positives = 318/792 (40%), Gaps = 65/792 (8%)
Query: 831 EPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSITWYRNNEII--SPSETITQNFDGEN 887
EPP+ + + E T G ++L V+ + ++ W++N E I P +G+
Sbjct: 339 EPPIMVTKQLEDTTAYCGERVELECEVSEDDA-NVKWFKNGEEIIPGPKSRYRIRVEGKK 397
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVI 947
L+I ++ D+ +Y + + G+SS A++++D++ + + L GK +
Sbjct: 398 HILIIEGA-TKADAAEYSVMTTG--GQSS--AKLSVDLKPLKILTPLTDQ-TVNLGKEIC 451
Query: 948 LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETS 1007
L+C+ S + KW N + D +++ +GR D G D
Sbjct: 452 LKCEISENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY-VFAPDAYNV 510
Query: 1008 TMLVVKETI--PEFIRKLQDFEVKEKDVA----ILEVEINSETAD-VVWERDGEIIKPKK 1060
T+ I P+ I D + +A LE+ I+ E +W R + I
Sbjct: 511 TLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGS 570
Query: 1061 NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA----EVTVVELPPEIITRLQNQ 1116
+ E L I D G Y L++E+ A +V VV+ P + +
Sbjct: 571 GRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTE 630
Query: 1117 KVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGE 1175
+ +E G + ++ +F + + Q S ++L D K+ + +
Sbjct: 631 VGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETT-FEPKKMIEGVA 689
Query: 1176 YSCEVGNSKCTAILTVEEPSINFT----LRLPEFILVPANTDAYLTVEI--PDE--TLDV 1227
Y + I PS F P + V + TD +T+ PD +
Sbjct: 690 YEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGL 749
Query: 1228 TWYKKKSVIEDTEKFTLISD--VKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV---- 1281
Y + E TE + + + + K I D + ++A ++ K
Sbjct: 750 DGYVLEYCFEGTEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQP 809
Query: 1282 ----EVVEFPPKI--VDYEREYRIKR-GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
E++E PPKI + ++ I+R G V L++ +Q P+P W + I K +
Sbjct: 810 ILVKEIIE-PPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQIN 868
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
+ ++ + + I+K E + +G Y L+++ + +++ I+D+P PP I ++
Sbjct: 869 IRNSETDTI-IFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWG 927
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRA 1453
++ + W P++ GN+ I Y ++ + + EW +V ++ +T +I L + Y FR
Sbjct: 928 ENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSATITELVIGNEYYFRV 987
Query: 1454 YAVNEVDIS-DASETTEYYKVIKETKI------------QSPTVEKPLKNITTEPNEDIE 1500
++ N +S DA+ T E + ++ KI ++P +PL N +
Sbjct: 988 FSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNAT 1047
Query: 1501 LTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRX--XXXXXXXXXXXXXXYKCIAFNDH 1556
L C G P+PK+TW ++ + + N+ Y C A ND
Sbjct: 1048 LNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDL 1107
Query: 1557 GEVETSCVVGIQ 1568
G VE C + ++
Sbjct: 1108 GTVEIECKLEVK 1119
Score = 114 bits (274), Expect = 4e-24
Identities = 125/500 (25%), Positives = 209/500 (41%), Gaps = 47/500 (9%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYT 1644
G++ + I G PPP+ +W + G+K + I T+ +S + I +R S Y
Sbjct: 540 GNKLRLEIPISGEPPPKAMWSR-GDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYH 598
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
I N AG + + +KV D P P P + E+ + + W+PP DGG + Y IE
Sbjct: 599 INLKNEAGEAHASIKVKVVDFPDPPVAPTVT-EVGDDWCIMNWEPPAYDGGSPILGYFIE 657
Query: 1705 KHEPDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKT 1762
+ + ++RW+++ D+ ++ T+ +K+ E Y R+ A N +G S+ ++ S P V
Sbjct: 658 RKKKQSSRWMRLNFDLCKET-TFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLA 716
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXX 1821
P+ + + +V + W P + G + + Y +E EG + W
Sbjct: 717 VTSPPT----LLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWIVANKDLI 772
Query: 1822 XXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS--QPRNFVVSES 1877
+ I L + R+ A N G S P I + + + PP PR+
Sbjct: 773 DKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRH------ 826
Query: 1878 TSRSVTLKWTEPESNGGSPITNYIIEF--KTVKGKSWTKIVTVGGSVHEHCIENIK--EK 1933
LK T G + N +I F K +W K G + ++ I NI+ E
Sbjct: 827 ------LKQTYIRRVGEA--VNLVIPFQGKPRPELTWKK---DGAEIDKNQI-NIRNSET 874
Query: 1934 DEIIFRISAENTVGVSLPTESQSVRLEKHATV-------PSPPTAPLEIRMVGSNIVMTS 1986
D IIF AE + + + + + A++ P PP + G N+ +T
Sbjct: 875 DTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALT- 933
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P+ DG A + GY I D W V + + I +L + Y R+++ N
Sbjct: 934 WTPPKDDGNAAITGYTIQKADKKSMEWFTVIE-HYHRTSATITELVIGNEYYFRVFSENM 992
Query: 2047 IGLSEPLESDEPFKVIPGEG 2066
GLSE + VI +G
Sbjct: 993 CGLSEDATMTKESAVIARDG 1012
Score = 78.2 bits (184), Expect = 3e-13
Identities = 158/754 (20%), Positives = 260/754 (34%), Gaps = 53/754 (7%)
Query: 1218 VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
VE+ D L+V WYK I + K+ +R L I C D EY D K +T
Sbjct: 274 VELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCST 333
Query: 1278 KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKKCKHT-K 1335
+L V PP +V + E + L + N +W N + II K +
Sbjct: 334 EL---FVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYR 390
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSS 1395
++ K L I+ DA Y + A + +++ L K P + +
Sbjct: 391 IRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPL-KILTPLTDQTVNLGKE 449
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
C G T V QE D + + I K + + Y F A
Sbjct: 450 ICLKCEISENIPGKWTKNGLPV--QESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDA 507
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N V + + K+I + TV T + L G P PK W
Sbjct: 508 YN-VTLPAKVHVIDPPKIILDGLDADNTV-------TVIAGNKLRLEIPISGEPPPKAMW 559
Query: 1516 YRDGKKL-----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
R K + + +Y + Y N+ GE S V +
Sbjct: 560 SRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDF 619
Query: 1571 PVITISNEDIKQKHKVGDEWLV----TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE- 1625
P ++ +VGD+W + +G P ++ Y K + + +
Sbjct: 620 PDPPVA----PTVTEVGDDWCIMNWEPPAYDGGSP--ILGYFIERKKKQSSRWMRLNFDL 673
Query: 1626 -KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR--EISRES 1682
K + K++ + + I A N G S + + + + P ++ ++ +
Sbjct: 674 CKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTT 733
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR-DVETYCIQKLNENCEYMFRV 1741
VT+ W+PP G L Y +E WI VA+ D D + I L + + RV
Sbjct: 734 VTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWI-VANKDLIDKTKFTITGLPTDAKIFVRV 792
Query: 1742 IAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
A N G SE S+PI++K ++ P + YI N +I
Sbjct: 793 KAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHL------KQTYIRRVGEAVN---LVI 843
Query: 1801 DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
++ + + E K I+ +T R R+ G DK
Sbjct: 844 PFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVET 903
Query: 1861 -----KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+ + P P+ + + +V L WT P+ +G + IT Y I+ K W +
Sbjct: 904 ASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTV 963
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVS 1949
+ I + +E FR+ +EN G+S
Sbjct: 964 IEHYHRT-SATITELVIGNEYYFRVFSENMCGLS 996
Score = 67.7 bits (158), Expect = 4e-10
Identities = 87/365 (23%), Positives = 144/365 (39%), Gaps = 19/365 (5%)
Query: 844 VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
V + G ++ V + +P + WY+N + I PS G L I N DS
Sbjct: 264 VDKGGRVRFVVELA-DPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEY 322
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH-TVSTKWYH 962
Y +AG + + + K L+ + G+ V LEC+ S + KW+
Sbjct: 323 YV-----TAGDEKCSTELFVREPPIMVTKQLEDT-TAYCGERVELECEVSEDDANVKWFK 376
Query: 963 NKKE-ISGMDHREIIQ-EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFI 1020
N +E I G R I+ EG+ D + ++S L V + +
Sbjct: 377 NGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKIL 436
Query: 1021 RKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTS 1080
L D V L+ EI SE W ++G ++ + ++ +G I KL I N
Sbjct: 437 TPLTDQTVNLGKEICLKCEI-SENIPGKWTKNGLPVQ-ESDRLKVVHKGRIHKLVIANAL 494
Query: 1081 VHDEGEYSCILRDESCT--AEVTVVELPPEIITRLQNQK---VNKGNKATFEIELT-KGD 1134
DEG+Y + T A+V V++ P I+ L V GNK EI ++ +
Sbjct: 495 TEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPP 554
Query: 1135 ALVRWFK-DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
W + D + ++ S I+ L I + DD+G Y + N A +++
Sbjct: 555 PKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKV 614
Query: 1194 PSINF 1198
++F
Sbjct: 615 KVVDF 619
Score = 60.9 bits (141), Expect = 5e-08
Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 4/111 (3%)
Query: 491 KIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAII 550
KI K PV+E + S AP+F + L + G C V G P+P+ITW + I
Sbjct: 1013 KIYKNPVYE---DFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAI 1069
Query: 551 KPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
++M + + V TL IR+ P D GT+ C A N G +L V+
Sbjct: 1070 VDDPRYRM-FSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1119
Score = 60.1 bits (139), Expect = 9e-08
Identities = 62/281 (22%), Positives = 111/281 (39%), Gaps = 25/281 (8%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIV--PDENISVAIESDMHMYCSVLKITNVKKFQE 705
G + LEC V+ + ++ W GEEI+ P + +E H +L I K
Sbjct: 356 GERVELECE-VSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKH----ILIIEGATKADA 410
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
Y+V+ + A L + LK P +++ PL V G+ + L ++ N
Sbjct: 411 AEYSVMTTGGQSSAKLSVDLK-------PLKILTPLTDQTVNLGKEICLKCEISENIPG- 462
Query: 766 ITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
W KN PV+ L G H + I +DEG Y A ++ + A + V
Sbjct: 463 -KWTKNGLPVQESDRLKVVHKGRIHKLVIAN-ALTEDEGDYVF-APDAYNVT-LPAKVHV 518
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
+P + + ++ +TV ++L ++ P P W R ++ I +
Sbjct: 519 IDPPKIILDG---LDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRT 575
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ ++ ++ DSG Y N AG++ +V +
Sbjct: 576 ESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKV 616
Score = 46.0 bits (104), Expect = 0.001
Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 2/93 (2%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITIL 792
E P +PL + G + L+ V GNP+P ITW KN + P + L
Sbjct: 1027 EAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTL 1086
Query: 793 KPKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
+ +K D G Y KA N G E + V+
Sbjct: 1087 EIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1119
Score = 38.3 bits (85), Expect = 0.30
Identities = 17/67 (25%), Positives = 31/67 (46%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ G P P++ W KN + +D Y + + + + I++ Y +A N GT
Sbjct: 1052 VRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVE 1111
Query: 1656 VEVTLKV 1662
+E L+V
Sbjct: 1112 IECKLEV 1118
Score = 37.5 bits (83), Expect = 0.52
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 733 EPPQVIEP--LKSMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHS 788
EPP++ P LK +R+ GE+V L G PRP +TW K+ + K + +T +
Sbjct: 817 EPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDT 876
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
I ++ + G Y L+ + + ET+++
Sbjct: 877 IIFIRKAERSHSGKYDLQVK-VDKFVETASI 906
Score = 35.1 bits (77), Expect = 2.8
Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 4/95 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F++ Y G + L C + P+P I W+ IV D + + C+
Sbjct: 1029 PMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGV---CT 1085
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
L+I + GTY AVN G + L++K
Sbjct: 1086 -LEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1119
>BC117217-1|AAI17218.1| 1120|Homo sapiens MYBPC1 protein protein.
Length = 1120
Score = 238 bits (582), Expect = 2e-61
Identities = 185/735 (25%), Positives = 325/735 (44%), Gaps = 32/735 (4%)
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
VE+ +V W ++G+ I+P KY FE +G R L+I N + D+ EY DE C+
Sbjct: 248 VELADPKLEVKWYKNGQEIRPS-TKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCS 306
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEI--QFSNHIQLT 1155
E+ V E P + +L++ G + E E+++ DA V+WFK+G EI + ++
Sbjct: 307 TELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIR 366
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAY 1215
++GKK L I DA EYS + +A L+V+ + L + V +
Sbjct: 367 VEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTD-QTVNLGKEIC 425
Query: 1216 LTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
L EI E + W K ++++++ ++ + L+I +D+ +Y
Sbjct: 426 LKCEI-SENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNV 484
Query: 1276 TTKLKVEVVEFPPKIV----DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKK 1330
T KV V++ PPKI+ D + + G+ + L + P P W K I++
Sbjct: 485 TLPAKVHVID-PPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEG 543
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
+ S++L I E D+G+Y + L+N G A + V ++D P PP P +
Sbjct: 544 SGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVT 603
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLK--TNSS 1448
E+ + W+ P G S I+ Y +E ++ ++ W+ + +T+ + K +
Sbjct: 604 EVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVA 663
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQS-PTVEKPLKNITT---EPNEDIELTCI 1504
Y R +AVN + IS S + + + T + TV+ T P + I +
Sbjct: 664 YEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGL 723
Query: 1505 FGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETS-- 1562
G V + + + A ++ + A N G E
Sbjct: 724 DGYVLE---YCFEGTEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYY 780
Query: 1563 ----CVVGIQQKPVITISNEDIKQKH--KVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
V I + P I I +KQ + +VG+ + +G P PE+ W K+G +++ +
Sbjct: 781 SQPILVKEIIEPPKIRIPRH-LKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKN 839
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
+ NI E ++I I++ +RSHS KY ++ + + +++ D+P P+ V +
Sbjct: 840 -QINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQ-IVKIE 897
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCE 1736
++ E+V + W PP DDG +T Y I+K + + W V + I +L E
Sbjct: 898 DVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSA-TITELVIGNE 956
Query: 1737 YMFRVIAQNPVGFSE 1751
Y FRV ++N G SE
Sbjct: 957 YYFRVFSENMCGLSE 971
Score = 132 bits (318), Expect = 2e-29
Identities = 147/629 (23%), Positives = 267/629 (42%), Gaps = 30/629 (4%)
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXX 984
+ F K L +Y+ ++G V + + + KWY N +EI +G
Sbjct: 224 KSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRIL 283
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D D++ ST L V+E ++L+D + LE E++ +
Sbjct: 284 FINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDD 343
Query: 1045 ADVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
A+V W ++G EII K++Y G L I + D EYS + +A+++V
Sbjct: 344 ANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVD 403
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
P +I+T L +Q VN G + + E+++ + +W K+G +Q S+ +++ G+ KL
Sbjct: 404 LKPLKILTPLTDQTVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKL 462
Query: 1164 KIYDCDLDDAGEY--SCEVGNSKCTA-ILTVEEPSINFT-LRLPEFILVPANTDAYLTVE 1219
I + +D G+Y + + N A + ++ P I L + V A L +
Sbjct: 463 VIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIP 522
Query: 1220 IPDETLDVTWYKK--KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKS 1275
I E + + K+++E + + S TL+I DD Y L + ++
Sbjct: 523 ISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEA 582
Query: 1276 TTKLKVEVVEFP-PKIVDYEREYRIKRGSDVTLL-VDYQAFP--QPNDEWIVNSKIIKKC 1331
+KV+VV+FP P + E G D ++ + A+ P + + K +
Sbjct: 583 HASIKVKVVDFPDPPVAPTVTEV----GDDWCIMNWEPPAYDGGSPILGYFIERKKKQSS 638
Query: 1332 KHTKPSID-SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
+ + + D K + KK+ A ++ N G + M + P +L
Sbjct: 639 RWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLL 698
Query: 1391 EIDS---SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKT 1445
+DS +++ + W P++ G + + YV+EY T +WI I KT+ +I L T
Sbjct: 699 TVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWIVANKDLIDKTKFTITGLPT 758
Query: 1446 NSSYRFRAYAVNEVDISDA---SETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
++ R AVN S+ S+ ++I+ KI+ P K + E + L
Sbjct: 759 DAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLK--QTYIRRVGEAVNLV 816
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
F G P+P++TW +DG ++ + N
Sbjct: 817 IPFQGKPRPELTWKKDGAEIDKNQINIRN 845
Score = 119 bits (287), Expect = 1e-25
Identities = 167/792 (21%), Positives = 318/792 (40%), Gaps = 65/792 (8%)
Query: 831 EPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSITWYRNNEII--SPSETITQNFDGEN 887
EPP+ + + E T G ++L V+ + ++ W++N E I P +G+
Sbjct: 313 EPPIMVTKQLEDTTAYCGERVELECEVSEDDA-NVKWFKNGEEIIPGPKSRYRIRVEGKK 371
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVI 947
L+I ++ D+ +Y + + G+SS A++++D++ + + L GK +
Sbjct: 372 HILIIEGA-TKADAAEYSVMTTG--GQSS--AKLSVDLKPLKILTPLTDQ-TVNLGKEIC 425
Query: 948 LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETS 1007
L+C+ S + KW N + D +++ +GR D G D
Sbjct: 426 LKCEISENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY-VFAPDAYNV 484
Query: 1008 TMLVVKETI--PEFIRKLQDFEVKEKDVA----ILEVEINSETAD-VVWERDGEIIKPKK 1060
T+ I P+ I D + +A LE+ I+ E +W R + I
Sbjct: 485 TLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGS 544
Query: 1061 NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA----EVTVVELPPEIITRLQNQ 1116
+ E L I D G Y L++E+ A +V VV+ P + +
Sbjct: 545 GRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTE 604
Query: 1117 KVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGE 1175
+ +E G + ++ +F + + Q S ++L D K+ + +
Sbjct: 605 VGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETT-FEPKKMIEGVA 663
Query: 1176 YSCEVGNSKCTAILTVEEPSINFT----LRLPEFILVPANTDAYLTVEI--PDE--TLDV 1227
Y + I PS F P + V + TD +T+ PD +
Sbjct: 664 YEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGL 723
Query: 1228 TWYKKKSVIEDTEKFTLISD--VKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV---- 1281
Y + E TE + + + + K I D + ++A ++ K
Sbjct: 724 DGYVLEYCFEGTEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQP 783
Query: 1282 ----EVVEFPPKI--VDYEREYRIKR-GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
E++E PPKI + ++ I+R G V L++ +Q P+P W + I K +
Sbjct: 784 ILVKEIIE-PPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQIN 842
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
+ ++ + + I+K E + +G Y L+++ + +++ I+D+P PP I ++
Sbjct: 843 IRNSETDTI-IFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWG 901
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRA 1453
++ + W P++ GN+ I Y ++ + + EW +V ++ +T +I L + Y FR
Sbjct: 902 ENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSATITELVIGNEYYFRV 961
Query: 1454 YAVNEVDIS-DASETTEYYKVIKETKI------------QSPTVEKPLKNITTEPNEDIE 1500
++ N +S DA+ T E + ++ KI ++P +PL N +
Sbjct: 962 FSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNAT 1021
Query: 1501 LTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRX--XXXXXXXXXXXXXXYKCIAFNDH 1556
L C G P+PK+TW ++ + + N+ Y C A ND
Sbjct: 1022 LNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDL 1081
Query: 1557 GEVETSCVVGIQ 1568
G VE C + ++
Sbjct: 1082 GTVEIECKLEVK 1093
Score = 114 bits (274), Expect = 4e-24
Identities = 125/500 (25%), Positives = 209/500 (41%), Gaps = 47/500 (9%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYT 1644
G++ + I G PPP+ +W + G+K + I T+ +S + I +R S Y
Sbjct: 514 GNKLRLEIPISGEPPPKAMWSR-GDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYH 572
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
I N AG + + +KV D P P P + E+ + + W+PP DGG + Y IE
Sbjct: 573 INLKNEAGEAHASIKVKVVDFPDPPVAPTVT-EVGDDWCIMNWEPPAYDGGSPILGYFIE 631
Query: 1705 KHEPDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKT 1762
+ + ++RW+++ D+ ++ T+ +K+ E Y R+ A N +G S+ ++ S P V
Sbjct: 632 RKKKQSSRWMRLNFDLCKET-TFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLA 690
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXX 1821
P+ + + +V + W P + G + + Y +E EG + W
Sbjct: 691 VTSPPT----LLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWIVANKDLI 746
Query: 1822 XXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS--QPRNFVVSES 1877
+ I L + R+ A N G S P I + + + PP PR+
Sbjct: 747 DKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRH------ 800
Query: 1878 TSRSVTLKWTEPESNGGSPITNYIIEF--KTVKGKSWTKIVTVGGSVHEHCIENIK--EK 1933
LK T G + N +I F K +W K G + ++ I NI+ E
Sbjct: 801 ------LKQTYIRRVGEA--VNLVIPFQGKPRPELTWKK---DGAEIDKNQI-NIRNSET 848
Query: 1934 DEIIFRISAENTVGVSLPTESQSVRLEKHATV-------PSPPTAPLEIRMVGSNIVMTS 1986
D IIF AE + + + + + A++ P PP + G N+ +T
Sbjct: 849 DTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALT- 907
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P+ DG A + GY I D W V + + I +L + Y R+++ N
Sbjct: 908 WTPPKDDGNAAITGYTIQKADKKSMEWFTVIE-HYHRTSATITELVIGNEYYFRVFSENM 966
Query: 2047 IGLSEPLESDEPFKVIPGEG 2066
GLSE + VI +G
Sbjct: 967 CGLSEDATMTKESAVIARDG 986
Score = 78.2 bits (184), Expect = 3e-13
Identities = 158/754 (20%), Positives = 260/754 (34%), Gaps = 53/754 (7%)
Query: 1218 VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
VE+ D L+V WYK I + K+ +R L I C D EY D K +T
Sbjct: 248 VELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCST 307
Query: 1278 KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKKCKHT-K 1335
+L V PP +V + E + L + N +W N + II K +
Sbjct: 308 EL---FVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYR 364
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSS 1395
++ K L I+ DA Y + A + +++ L K P + +
Sbjct: 365 IRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPL-KILTPLTDQTVNLGKE 423
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
C G T V QE D + + I K + + Y F A
Sbjct: 424 ICLKCEISENIPGKWTKNGLPV--QESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDA 481
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N V + + K+I + TV T + L G P PK W
Sbjct: 482 YN-VTLPAKVHVIDPPKIILDGLDADNTV-------TVIAGNKLRLEIPISGEPPPKAMW 533
Query: 1516 YRDGKKL-----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
R K + + +Y + Y N+ GE S V +
Sbjct: 534 SRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDF 593
Query: 1571 PVITISNEDIKQKHKVGDEWLV----TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE- 1625
P ++ +VGD+W + +G P ++ Y K + + +
Sbjct: 594 PDPPVA----PTVTEVGDDWCIMNWEPPAYDGGSP--ILGYFIERKKKQSSRWMRLNFDL 647
Query: 1626 -KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR--EISRES 1682
K + K++ + + I A N G S + + + + P ++ ++ +
Sbjct: 648 CKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTT 707
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR-DVETYCIQKLNENCEYMFRV 1741
VT+ W+PP G L Y +E WI VA+ D D + I L + + RV
Sbjct: 708 VTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWI-VANKDLIDKTKFTITGLPTDAKIFVRV 766
Query: 1742 IAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
A N G SE S+PI++K ++ P + YI N +I
Sbjct: 767 KAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHL------KQTYIRRVGEAVN---LVI 817
Query: 1801 DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
++ + + E K I+ +T R R+ G DK
Sbjct: 818 PFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVET 877
Query: 1861 -----KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+ + P P+ + + +V L WT P+ +G + IT Y I+ K W +
Sbjct: 878 ASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTV 937
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVS 1949
+ I + +E FR+ +EN G+S
Sbjct: 938 IEHYHRT-SATITELVIGNEYYFRVFSENMCGLS 970
Score = 67.7 bits (158), Expect = 4e-10
Identities = 87/365 (23%), Positives = 144/365 (39%), Gaps = 19/365 (5%)
Query: 844 VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
V + G ++ V + +P + WY+N + I PS G L I N DS
Sbjct: 238 VDKGGRVRFVVELA-DPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEY 296
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH-TVSTKWYH 962
Y +AG + + + K L+ + G+ V LEC+ S + KW+
Sbjct: 297 YV-----TAGDEKCSTELFVREPPIMVTKQLEDT-TAYCGERVELECEVSEDDANVKWFK 350
Query: 963 NKKE-ISGMDHREIIQ-EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFI 1020
N +E I G R I+ EG+ D + ++S L V + +
Sbjct: 351 NGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKIL 410
Query: 1021 RKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTS 1080
L D V L+ EI SE W ++G ++ + ++ +G I KL I N
Sbjct: 411 TPLTDQTVNLGKEICLKCEI-SENIPGKWTKNGLPVQ-ESDRLKVVHKGRIHKLVIANAL 468
Query: 1081 VHDEGEYSCILRDESCT--AEVTVVELPPEIITRLQNQK---VNKGNKATFEIELT-KGD 1134
DEG+Y + T A+V V++ P I+ L V GNK EI ++ +
Sbjct: 469 TEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPP 528
Query: 1135 ALVRWFK-DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
W + D + ++ S I+ L I + DD+G Y + N A +++
Sbjct: 529 PKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKV 588
Query: 1194 PSINF 1198
++F
Sbjct: 589 KVVDF 593
Score = 60.9 bits (141), Expect = 5e-08
Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 4/111 (3%)
Query: 491 KIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAII 550
KI K PV+E + S AP+F + L + G C V G P+P+ITW + I
Sbjct: 987 KIYKNPVYE---DFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAI 1043
Query: 551 KPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
++M + + V TL IR+ P D GT+ C A N G +L V+
Sbjct: 1044 VDDPRYRM-FSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1093
Score = 60.1 bits (139), Expect = 9e-08
Identities = 62/281 (22%), Positives = 111/281 (39%), Gaps = 25/281 (8%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIV--PDENISVAIESDMHMYCSVLKITNVKKFQE 705
G + LEC V+ + ++ W GEEI+ P + +E H +L I K
Sbjct: 330 GERVELECE-VSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKH----ILIIEGATKADA 384
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
Y+V+ + A L + LK P +++ PL V G+ + L ++ N
Sbjct: 385 AEYSVMTTGGQSSAKLSVDLK-------PLKILTPLTDQTVNLGKEICLKCEISENIPG- 436
Query: 766 ITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
W KN PV+ L G H + I +DEG Y A ++ + A + V
Sbjct: 437 -KWTKNGLPVQESDRLKVVHKGRIHKLVIAN-ALTEDEGDYVF-APDAYNVT-LPAKVHV 492
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
+P + + ++ +TV ++L ++ P P W R ++ I +
Sbjct: 493 IDPPKIILDG---LDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRT 549
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ ++ ++ DSG Y N AG++ +V +
Sbjct: 550 ESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKV 590
Score = 46.0 bits (104), Expect = 0.001
Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 2/93 (2%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITIL 792
E P +PL + G + L+ V GNP+P ITW KN + P + L
Sbjct: 1001 EAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTL 1060
Query: 793 KPKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
+ +K D G Y KA N G E + V+
Sbjct: 1061 EIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1093
Score = 39.9 bits (89), Expect = 0.098
Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ G P P++ W KN + +D Y + + + + I++ Y +A N GT
Sbjct: 1026 VRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVE 1085
Query: 1656 VEVTLKV---YDKPSKPEGPVIM 1675
+E L+V Y + P PV +
Sbjct: 1086 IECKLEVKVIYQGVNTPGQPVFL 1108
Score = 37.5 bits (83), Expect = 0.52
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 733 EPPQVIEP--LKSMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHS 788
EPP++ P LK +R+ GE+V L G PRP +TW K+ + K + +T +
Sbjct: 791 EPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDT 850
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
I ++ + G Y L+ + + ET+++
Sbjct: 851 IIFIRKAERSHSGKYDLQVK-VDKFVETASI 880
Score = 35.1 bits (77), Expect = 2.8
Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 4/95 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F++ Y G + L C + P+P I W+ IV D + + C+
Sbjct: 1003 PMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGV---CT 1059
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
L+I + GTY AVN G + L++K
Sbjct: 1060 -LEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1093
Score = 34.3 bits (75), Expect = 4.9
Identities = 24/100 (24%), Positives = 41/100 (41%), Gaps = 3/100 (3%)
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
G + TL + P+P W+ N I + + +L I+K D G Y +
Sbjct: 1017 GYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCK 1076
Query: 1362 LENNCGHADVEMNV---TILDKPSPPGKPNILEIDSSSIN 1398
N+ G ++E + I + PG+P LE S++
Sbjct: 1077 AVNDLGTVEIECKLEVKVIYQGVNTPGQPVFLEGQQQSLH 1116
>BC092418-1|AAH92418.1| 1123|Homo sapiens myosin binding protein C,
slow type protein.
Length = 1123
Score = 238 bits (582), Expect = 2e-61
Identities = 185/735 (25%), Positives = 325/735 (44%), Gaps = 32/735 (4%)
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
VE+ +V W ++G+ I+P KY FE +G R L+I N + D+ EY DE C+
Sbjct: 274 VELADPKLEVKWYKNGQEIRPS-TKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCS 332
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEI--QFSNHIQLT 1155
E+ V E P + +L++ G + E E+++ DA V+WFK+G EI + ++
Sbjct: 333 TELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIR 392
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAY 1215
++GKK L I DA EYS + +A L+V+ + L + V +
Sbjct: 393 VEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTD-QTVNLGKEIC 451
Query: 1216 LTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
L EI E + W K ++++++ ++ + L+I +D+ +Y
Sbjct: 452 LKCEI-SENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNV 510
Query: 1276 TTKLKVEVVEFPPKIV----DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKK 1330
T KV V++ PPKI+ D + + G+ + L + P P W K I++
Sbjct: 511 TLPAKVHVID-PPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEG 569
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
+ S++L I E D+G+Y + L+N G A + V ++D P PP P +
Sbjct: 570 SGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVT 629
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLK--TNSS 1448
E+ + W+ P G S I+ Y +E ++ ++ W+ + +T+ + K +
Sbjct: 630 EVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVA 689
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQS-PTVEKPLKNITT---EPNEDIELTCI 1504
Y R +AVN + IS S + + + T + TV+ T P + I +
Sbjct: 690 YEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGL 749
Query: 1505 FGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETS-- 1562
G V + + + A ++ + A N G E
Sbjct: 750 DGYVLE---YCFEGTEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYY 806
Query: 1563 ----CVVGIQQKPVITISNEDIKQKH--KVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
V I + P I I +KQ + +VG+ + +G P PE+ W K+G +++ +
Sbjct: 807 SQPILVKEIIEPPKIRIPRH-LKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKN 865
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
+ NI E ++I I++ +RSHS KY ++ + + +++ D+P P+ V +
Sbjct: 866 -QINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQ-IVKIE 923
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCE 1736
++ E+V + W PP DDG +T Y I+K + + W V + I +L E
Sbjct: 924 DVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSA-TITELVIGNE 982
Query: 1737 YMFRVIAQNPVGFSE 1751
Y FRV ++N G SE
Sbjct: 983 YYFRVFSENMCGLSE 997
Score = 132 bits (318), Expect = 2e-29
Identities = 147/629 (23%), Positives = 267/629 (42%), Gaps = 30/629 (4%)
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXX 984
+ F K L +Y+ ++G V + + + KWY N +EI +G
Sbjct: 250 KSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRIL 309
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D D++ ST L V+E ++L+D + LE E++ +
Sbjct: 310 FINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDD 369
Query: 1045 ADVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
A+V W ++G EII K++Y G L I + D EYS + +A+++V
Sbjct: 370 ANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVD 429
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
P +I+T L +Q VN G + + E+++ + +W K+G +Q S+ +++ G+ KL
Sbjct: 430 LKPLKILTPLTDQTVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKL 488
Query: 1164 KIYDCDLDDAGEY--SCEVGNSKCTA-ILTVEEPSINFT-LRLPEFILVPANTDAYLTVE 1219
I + +D G+Y + + N A + ++ P I L + V A L +
Sbjct: 489 VIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIP 548
Query: 1220 IPDETLDVTWYKK--KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKS 1275
I E + + K+++E + + S TL+I DD Y L + ++
Sbjct: 549 ISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEA 608
Query: 1276 TTKLKVEVVEFP-PKIVDYEREYRIKRGSDVTLL-VDYQAFP--QPNDEWIVNSKIIKKC 1331
+KV+VV+FP P + E G D ++ + A+ P + + K +
Sbjct: 609 HASIKVKVVDFPDPPVAPTVTEV----GDDWCIMNWEPPAYDGGSPILGYFIERKKKQSS 664
Query: 1332 KHTKPSID-SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
+ + + D K + KK+ A ++ N G + M + P +L
Sbjct: 665 RWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLL 724
Query: 1391 EIDS---SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKT 1445
+DS +++ + W P++ G + + YV+EY T +WI I KT+ +I L T
Sbjct: 725 TVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWIVANKDLIDKTKFTITGLPT 784
Query: 1446 NSSYRFRAYAVNEVDISDA---SETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
++ R AVN S+ S+ ++I+ KI+ P K + E + L
Sbjct: 785 DAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLK--QTYIRRVGEAVNLV 842
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
F G P+P++TW +DG ++ + N
Sbjct: 843 IPFQGKPRPELTWKKDGAEIDKNQINIRN 871
Score = 119 bits (287), Expect = 1e-25
Identities = 167/792 (21%), Positives = 318/792 (40%), Gaps = 65/792 (8%)
Query: 831 EPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSITWYRNNEII--SPSETITQNFDGEN 887
EPP+ + + E T G ++L V+ + ++ W++N E I P +G+
Sbjct: 339 EPPIMVTKQLEDTTAYCGERVELECEVSEDDA-NVKWFKNGEEIIPGPKSRYRIRVEGKK 397
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVI 947
L+I ++ D+ +Y + + G+SS A++++D++ + + L GK +
Sbjct: 398 HILIIEGA-TKADAAEYSVMTTG--GQSS--AKLSVDLKPLKILTPLTDQ-TVNLGKEIC 451
Query: 948 LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETS 1007
L+C+ S + KW N + D +++ +GR D G D
Sbjct: 452 LKCEISENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDY-VFAPDAYNV 510
Query: 1008 TMLVVKETI--PEFIRKLQDFEVKEKDVA----ILEVEINSETAD-VVWERDGEIIKPKK 1060
T+ I P+ I D + +A LE+ I+ E +W R + I
Sbjct: 511 TLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGS 570
Query: 1061 NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA----EVTVVELPPEIITRLQNQ 1116
+ E L I D G Y L++E+ A +V VV+ P + +
Sbjct: 571 GRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTE 630
Query: 1117 KVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGE 1175
+ +E G + ++ +F + + Q S ++L D K+ + +
Sbjct: 631 VGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETT-FEPKKMIEGVA 689
Query: 1176 YSCEVGNSKCTAILTVEEPSINFT----LRLPEFILVPANTDAYLTVEI--PDE--TLDV 1227
Y + I PS F P + V + TD +T+ PD +
Sbjct: 690 YEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGL 749
Query: 1228 TWYKKKSVIEDTEKFTLISD--VKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV---- 1281
Y + E TE + + + + K I D + ++A ++ K
Sbjct: 750 DGYVLEYCFEGTEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQP 809
Query: 1282 ----EVVEFPPKI--VDYEREYRIKR-GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
E++E PPKI + ++ I+R G V L++ +Q P+P W + I K +
Sbjct: 810 ILVKEIIE-PPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQIN 868
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
+ ++ + + I+K E + +G Y L+++ + +++ I+D+P PP I ++
Sbjct: 869 IRNSETDTI-IFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWG 927
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRA 1453
++ + W P++ GN+ I Y ++ + + EW +V ++ +T +I L + Y FR
Sbjct: 928 ENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSATITELVIGNEYYFRV 987
Query: 1454 YAVNEVDIS-DASETTEYYKVIKETKI------------QSPTVEKPLKNITTEPNEDIE 1500
++ N +S DA+ T E + ++ KI ++P +PL N +
Sbjct: 988 FSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNAT 1047
Query: 1501 LTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRX--XXXXXXXXXXXXXXYKCIAFNDH 1556
L C G P+PK+TW ++ + + N+ Y C A ND
Sbjct: 1048 LNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDL 1107
Query: 1557 GEVETSCVVGIQ 1568
G VE C + ++
Sbjct: 1108 GTVEIECKLEVK 1119
Score = 114 bits (274), Expect = 4e-24
Identities = 125/500 (25%), Positives = 209/500 (41%), Gaps = 47/500 (9%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYT 1644
G++ + I G PPP+ +W + G+K + I T+ +S + I +R S Y
Sbjct: 540 GNKLRLEIPISGEPPPKAMWSR-GDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYH 598
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
I N AG + + +KV D P P P + E+ + + W+PP DGG + Y IE
Sbjct: 599 INLKNEAGEAHASIKVKVVDFPDPPVAPTVT-EVGDDWCIMNWEPPAYDGGSPILGYFIE 657
Query: 1705 KHEPDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKT 1762
+ + ++RW+++ D+ ++ T+ +K+ E Y R+ A N +G S+ ++ S P V
Sbjct: 658 RKKKQSSRWMRLNFDLCKET-TFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLA 716
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXX 1821
P+ + + +V + W P + G + + Y +E EG + W
Sbjct: 717 VTSPPT----LLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWIVANKDLI 772
Query: 1822 XXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS--QPRNFVVSES 1877
+ I L + R+ A N G S P I + + + PP PR+
Sbjct: 773 DKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRH------ 826
Query: 1878 TSRSVTLKWTEPESNGGSPITNYIIEF--KTVKGKSWTKIVTVGGSVHEHCIENIK--EK 1933
LK T G + N +I F K +W K G + ++ I NI+ E
Sbjct: 827 ------LKQTYIRRVGEA--VNLVIPFQGKPRPELTWKK---DGAEIDKNQI-NIRNSET 874
Query: 1934 DEIIFRISAENTVGVSLPTESQSVRLEKHATV-------PSPPTAPLEIRMVGSNIVMTS 1986
D IIF AE + + + + + A++ P PP + G N+ +T
Sbjct: 875 DTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALT- 933
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P+ DG A + GY I D W V + + I +L + Y R+++ N
Sbjct: 934 WTPPKDDGNAAITGYTIQKADKKSMEWFTVIE-HYHRTSATITELVIGNEYYFRVFSENM 992
Query: 2047 IGLSEPLESDEPFKVIPGEG 2066
GLSE + VI +G
Sbjct: 993 CGLSEDATMTKESAVIARDG 1012
Score = 78.2 bits (184), Expect = 3e-13
Identities = 158/754 (20%), Positives = 260/754 (34%), Gaps = 53/754 (7%)
Query: 1218 VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
VE+ D L+V WYK I + K+ +R L I C D EY D K +T
Sbjct: 274 VELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCST 333
Query: 1278 KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKKCKHT-K 1335
+L V PP +V + E + L + N +W N + II K +
Sbjct: 334 EL---FVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYR 390
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSS 1395
++ K L I+ DA Y + A + +++ L K P + +
Sbjct: 391 IRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPL-KILTPLTDQTVNLGKE 449
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
C G T V QE D + + I K + + Y F A
Sbjct: 450 ICLKCEISENIPGKWTKNGLPV--QESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDA 507
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N V + + K+I + TV T + L G P PK W
Sbjct: 508 YN-VTLPAKVHVIDPPKIILDGLDADNTV-------TVIAGNKLRLEIPISGEPPPKAMW 559
Query: 1516 YRDGKKL-----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
R K + + +Y + Y N+ GE S V +
Sbjct: 560 SRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDF 619
Query: 1571 PVITISNEDIKQKHKVGDEWLV----TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE- 1625
P ++ +VGD+W + +G P ++ Y K + + +
Sbjct: 620 PDPPVA----PTVTEVGDDWCIMNWEPPAYDGGSP--ILGYFIERKKKQSSRWMRLNFDL 673
Query: 1626 -KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR--EISRES 1682
K + K++ + + I A N G S + + + + P ++ ++ +
Sbjct: 674 CKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTT 733
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR-DVETYCIQKLNENCEYMFRV 1741
VT+ W+PP G L Y +E WI VA+ D D + I L + + RV
Sbjct: 734 VTMRWRPPDHIGAAGLDGYVLEYCFEGTEDWI-VANKDLIDKTKFTITGLPTDAKIFVRV 792
Query: 1742 IAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
A N G SE S+PI++K ++ P + YI N +I
Sbjct: 793 KAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHL------KQTYIRRVGEAVN---LVI 843
Query: 1801 DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
++ + + E K I+ +T R R+ G DK
Sbjct: 844 PFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVET 903
Query: 1861 -----KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+ + P P+ + + +V L WT P+ +G + IT Y I+ K W +
Sbjct: 904 ASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTV 963
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVS 1949
+ I + +E FR+ +EN G+S
Sbjct: 964 IEHYHRT-SATITELVIGNEYYFRVFSENMCGLS 996
Score = 67.7 bits (158), Expect = 4e-10
Identities = 87/365 (23%), Positives = 144/365 (39%), Gaps = 19/365 (5%)
Query: 844 VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
V + G ++ V + +P + WY+N + I PS G L I N DS
Sbjct: 264 VDKGGRVRFVVELA-DPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEY 322
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH-TVSTKWYH 962
Y +AG + + + K L+ + G+ V LEC+ S + KW+
Sbjct: 323 YV-----TAGDEKCSTELFVREPPIMVTKQLEDT-TAYCGERVELECEVSEDDANVKWFK 376
Query: 963 NKKE-ISGMDHREIIQ-EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFI 1020
N +E I G R I+ EG+ D + ++S L V + +
Sbjct: 377 NGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKIL 436
Query: 1021 RKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTS 1080
L D V L+ EI SE W ++G ++ + ++ +G I KL I N
Sbjct: 437 TPLTDQTVNLGKEICLKCEI-SENIPGKWTKNGLPVQ-ESDRLKVVHKGRIHKLVIANAL 494
Query: 1081 VHDEGEYSCILRDESCT--AEVTVVELPPEIITRLQNQK---VNKGNKATFEIELT-KGD 1134
DEG+Y + T A+V V++ P I+ L V GNK EI ++ +
Sbjct: 495 TEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPP 554
Query: 1135 ALVRWFK-DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
W + D + ++ S I+ L I + DD+G Y + N A +++
Sbjct: 555 PKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKV 614
Query: 1194 PSINF 1198
++F
Sbjct: 615 KVVDF 619
Score = 60.9 bits (141), Expect = 5e-08
Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 4/111 (3%)
Query: 491 KIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAII 550
KI K PV+E + S AP+F + L + G C V G P+P+ITW + I
Sbjct: 1013 KIYKNPVYE---DFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAI 1069
Query: 551 KPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
++M + + V TL IR+ P D GT+ C A N G +L V+
Sbjct: 1070 VDDPRYRM-FSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1119
Score = 60.1 bits (139), Expect = 9e-08
Identities = 62/281 (22%), Positives = 111/281 (39%), Gaps = 25/281 (8%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIV--PDENISVAIESDMHMYCSVLKITNVKKFQE 705
G + LEC V+ + ++ W GEEI+ P + +E H +L I K
Sbjct: 356 GERVELECE-VSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKH----ILIIEGATKADA 410
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
Y+V+ + A L + LK P +++ PL V G+ + L ++ N
Sbjct: 411 AEYSVMTTGGQSSAKLSVDLK-------PLKILTPLTDQTVNLGKEICLKCEISENIPG- 462
Query: 766 ITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
W KN PV+ L G H + I +DEG Y A ++ + A + V
Sbjct: 463 -KWTKNGLPVQESDRLKVVHKGRIHKLVIAN-ALTEDEGDYVF-APDAYNVT-LPAKVHV 518
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
+P + + ++ +TV ++L ++ P P W R ++ I +
Sbjct: 519 IDPPKIILDG---LDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRT 575
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ ++ ++ DSG Y N AG++ +V +
Sbjct: 576 ESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKV 616
Score = 46.0 bits (104), Expect = 0.001
Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 2/93 (2%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITIL 792
E P +PL + G + L+ V GNP+P ITW KN + P + L
Sbjct: 1027 EAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTL 1086
Query: 793 KPKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
+ +K D G Y KA N G E + V+
Sbjct: 1087 EIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1119
Score = 38.3 bits (85), Expect = 0.30
Identities = 17/67 (25%), Positives = 31/67 (46%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ G P P++ W KN + +D Y + + + + I++ Y +A N GT
Sbjct: 1052 VRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVE 1111
Query: 1656 VEVTLKV 1662
+E L+V
Sbjct: 1112 IECKLEV 1118
Score = 37.5 bits (83), Expect = 0.52
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 733 EPPQVIEP--LKSMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHS 788
EPP++ P LK +R+ GE+V L G PRP +TW K+ + K + +T +
Sbjct: 817 EPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDT 876
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
I ++ + G Y L+ + + ET+++
Sbjct: 877 IIFIRKAERSHSGKYDLQVK-VDKFVETASI 906
Score = 35.1 bits (77), Expect = 2.8
Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 4/95 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F++ Y G + L C + P+P I W+ IV D + + C+
Sbjct: 1029 PMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGV---CT 1085
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
L+I + GTY AVN G + L++K
Sbjct: 1086 -LEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1119
>BX928748-1|CAH74051.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone RP11-465I11 on chromosome 1. ).
Length = 5635
Score = 235 bits (574), Expect = 2e-60
Identities = 291/1201 (24%), Positives = 482/1201 (40%), Gaps = 129/1201 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ EC+V+G P P +TW + + ++ ++ D+ ++ L ++ + D G + C
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHI--LQLKNIHVSDTGRYVC 2363
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA N AG +L V AP S G+ + P S
Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRS--------------------PENIS------ 2397
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V E + + L C IP P I W FK V N SV I S M L++
Sbjct: 2398 -VVEKNSVSLTCEASGIPLPSITW-FKDGWPVSLSN-SVRILSGGRM----LRLMQTTME 2450
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGN 761
G YT V N GE L + PP ++ L+ + V++ +SV L+ +V GN
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLV----PPHIVGENTLEDVKVKEKQSVTLTCEVTGN 2506
Query: 762 PRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P ITW K+ +P+ +A S G IT + +V G YT A + G S
Sbjct: 2507 PVPEITWHKDGQPLQEDEAHHIISGGRFLQITNV---QVPHTGRYTCLASSPAGHKSRSF 2563
Query: 819 VITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+ V PT +++TV LV P +ITW+++ + +
Sbjct: 2564 SLNVFVSPTIAGVGSD---GNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2620
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL--- 934
I G ++++ D ++G Y CVA+N AG+ V + + + L
Sbjct: 2621 NIRILPGGRTLQILNAQED---NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGP 2677
Query: 935 ---QKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
K + + T+ LEC+ + S WY + + + DH I G
Sbjct: 2678 GLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2735
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIRKLQDF--------EVKEKDVAI---- 1035
D G C+ + E V +P +KL + + KDV I
Sbjct: 2736 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 1036 -LEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L E N + + W +DG + +K G R L I V D G Y+C+ +
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPL-TSSDKVLILPGG--RVLQIPRAKVEDAGRYTCVAVN 2852
Query: 1094 ES--CTAEVTVVELPPEII----TRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSE 1145
E+ + + V L P II + L + NK+ L+ G R W KDG
Sbjct: 2853 EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2912
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
+ +H + +G+ L+I + + D G Y C G++K L V P +
Sbjct: 2913 LLEDDHHKFLSNGR--ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970
Query: 1202 LPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E + V N LT E+ D++W K + I+ ++ RTL I +
Sbjct: 2971 -SENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG--GRTLQIIRAKV 3027
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE----YRIKRGSDVTLLVDYQAFP 1315
D EYTC+ ++ +K K + V PP I D++ E ++ G+ V+L + A P
Sbjct: 3028 SDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W N ++I + H + D + L IKK E +D G Y R N G D ++
Sbjct: 3088 PPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145
Query: 1376 TILDKPS--PPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+ PS P + I+E S+ + + D TG I ++ ++ I+ ++ + V+
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDA---TGIPPPTIAWLKNHKRIENSDSLEVRI 3202
Query: 1433 IT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
++ ++ I + + S + A N + +YY + + E P ++
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNM-----EGKAQKYYFLSIQVPPSVAGAEIP-SDV 3256
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXXXXXXXX 1547
+ E++EL C G+P P + W +DGK + + + N
Sbjct: 3257 SVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3316
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIW 1606
Y C+A N GE + + + P I + ++ ++ + D + + G PPP++ W
Sbjct: 3317 YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW 3376
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
KNG L + + VIRI + S + YT ASN AG + L+V+ P
Sbjct: 3377 LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPP 3434
Query: 1667 S 1667
+
Sbjct: 3435 N 3435
Score = 215 bits (525), Expect = 1e-54
Identities = 273/1202 (22%), Positives = 469/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 1027
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 1082
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 1083 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 1125
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA N G + + L + PP++
Sbjct: 1126 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV----PPKIQR 1175
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 800 EGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+E PT E+ EPP + FQE ++ A+ T
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 1293
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + + LVI +V + D+G+Y CVA N AG +
Sbjct: 1294 -PKPTIKWLHNGRELTGREPGISILEDGTL-LVIASV-TPYDNGEYICVAVNEAGTTERK 1350
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 1351 YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTM-----LVVKETIPEFIRKLQDFEVKE 1030
G+ D G C + TS ++V TI + V
Sbjct: 1411 NNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN 1468
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ + D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 1469 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 1525
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 1586 QPIMSSSQ-ALYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 1638
Query: 1204 EFI----LVPANTDAY----LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + + + KK
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK-- 1696
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLV 1309
L I E D+ +Y CV ++K EV V PP I D + + + + L
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + ++I + K ++ + + +V NT G+Y+ N G
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 1814
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 1815 KKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQ--- 1871
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 1872 -GNL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 1926
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR-XXXXXXXXXXXXX 1545
N T + ++L C G P P +TWY+D + L + T+ NR
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDA 1986
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLT 2044
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 2045 WLKDGSPVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 1666 PS 1667
P+
Sbjct: 2104 PN 2105
Score = 209 bits (511), Expect = 7e-53
Identities = 270/1179 (22%), Positives = 456/1179 (38%), Gaps = 93/1179 (7%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 1233
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 1234 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTVE------------DLEPPYNTT 1274
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F ++ Q ++ C P+P I WL G E+ E ++I D ++L
Sbjct: 1275 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREP-GISILEDG----TLL 1323
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVI 753
I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVTNVSVLLNQLTN 1379
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439
Query: 814 AETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
++ I V P P + F E++V + L +V P P I W+++ +
Sbjct: 1440 SQKYFNIDVLVP------PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 1494 LFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Query: 933 HLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ + LEC+T + WY + + I I +G+
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611
Query: 991 XXDVGVIKCIVKDQETST--MLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-- 1046
D C V + + V +P I + ++ V + + + A
Sbjct: 1612 --DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNP 1669
Query: 1047 ---VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
+ W +DG +K N E G +KL I + D G+Y C+ + E+
Sbjct: 1670 SPILTWLKDGVPVKANDN-IRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYE 1726
Query: 1103 --VELPPEIITRLQNQK--VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
V +PP I + V N + +T + W KDG I + ++ ++
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLN 1786
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVPANTD 1213
G+K L I + + G Y C N+ K +TV P + L E ++V
Sbjct: 1787 GRK--LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
A + +TW K + +T + L R L I K +D YTCV +A
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903
Query: 1274 KSTTKLKVEV-VEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
T+ +++ V PP + D + + + V L P P W +++++
Sbjct: 1904 AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSG 1963
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N++
Sbjct: 1964 S--TSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMV 2021
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ ++ E ++ + + + V + + ++ + + + + R
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQISDTGR 2080
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 2081 YTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Query: 1511 PKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
P +TW +DG L K + ENR Y C A N G+ E + V I
Sbjct: 2133 PTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW 2192
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I S+E + G+ + GIPPP +IW K G+ + D +
Sbjct: 2193 VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR 2252
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++I ++S ++ Y+ ASN AGT+ E L+VY +P+
Sbjct: 2253 QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPT 2291
Score = 200 bits (488), Expect = 4e-50
Identities = 249/1088 (22%), Positives = 430/1088 (39%), Gaps = 92/1088 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+ S V + + LEC IP P + WL G + N +
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+L +T+ + G YT VAVN GE I L++ PP ++ +++ V ++
Sbjct: 2067 --ILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV----PPNIMGEEQNVSVLISQA 2120
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
V L Q P PT+TW K+ P+ P S + S+ ++ +V+D G YT +A N
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YRNN 870
G E + + + P L ++TV E I L+ + P P++ W + +
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIWKKKGS 2235
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKV 928
+++ S + G +L I ++ + D+ Y CVASN AG K + +V I
Sbjct: 2236 PVLTDSMGRVRILSGGR-QLQI-SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTIT 2293
Query: 929 TFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
H + T GK++ LEC+ + W + + EI+ EG
Sbjct: 2294 NSGSHPTEIIVT-RGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQL 2350
Query: 987 XXXXXXDVGVIKCI------VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + D++ + +I R ++ V EK+ L E
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 1041 NS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ESC 1096
+ + W +DG + N G R L + T++ D G+Y+C++R+ E
Sbjct: 2411 SGIPLPSITWFKDGWPVS-LSNSVRILSGG--RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467
Query: 1097 TAEVTVVELPPEII--TRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQ 1153
V +PP I+ L++ KV + T E+T + W KDG +Q
Sbjct: 2468 KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHH 2527
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSIN--FTLRLPEFI 1206
+ G+ L+I + + G Y+C + S+ ++ P+I + PE +
Sbjct: 2528 IISGGR--FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV 2585
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V N+ L E +TW+K + +E ++ RTL I ED+
Sbjct: 2586 TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG--GRTLQILNAQEDNAGR 2643
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVD---------YEREYRIKRGSDVTLLVDYQAFPQ 1316
Y+CV + EV + P I++ +E +IK + +TL + A P
Sbjct: 2644 YSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPS 2703
Query: 1317 PNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+ W + + +K H +I + +L IK+ + +D G Y N G +++ +V
Sbjct: 2704 ASLSWYKDGQPLKSDDHV--NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVN 2761
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENT--GNSTIIYYVVEYQEIDTTEWISVKN-I 1433
I PP + EI + E ++ N +Y T W + +
Sbjct: 2762 I---QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 1434 TKTQ----------TSIQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQSP 1482
T + I K + R+ AVNE ++ +Y +V+ I+
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA----GEDSLQYDVRVLVPPIIKGA 2874
Query: 1483 TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXX 1540
+ P + +T N+ + C+ G P P+ +W +DG+ L N
Sbjct: 2875 NSDLP-EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQKP-VITISNEDIKQKHKVGDEWLVTAVIEGI 1599
Y C+A N G + + + P VI +E++ V + +T + G
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV--VVNNFISLTCEVSGF 2991
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
PPP++ W KN ++ + I +T ++I K S +YT A N AG S + +
Sbjct: 2992 PPPDLSWLKNEQPIKLNTNTLIVPGGRT--LQIIRAKVSDGGEYTCIAINQAGESKKKFS 3049
Query: 1660 LKVYDKPS 1667
L VY PS
Sbjct: 3050 LTVYVPPS 3057
Score = 197 bits (481), Expect = 3e-49
Identities = 269/1219 (22%), Positives = 480/1219 (39%), Gaps = 120/1219 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S ++ EC+ G P P ITW++ I S +Y D + +V D+ T+TC
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQ-ALYIDKGQYLHIPRAQV--SDSATYTCH 1619
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
N AG A + + V P ++EG T P +
Sbjct: 1620 VANVAGTAEKSFHVDVYVP-----------------------PMIEGNLAT----PLNKQ 1652
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + LEC+ P P + WL G + ++NI + L+I + ++
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK------LEIMSAQEID 1706
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGNP 762
G Y VA + GE + K + PP + + IV + L V G+P
Sbjct: 1707 RGQYICVATSVAGEKEI----KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 763 RPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
PTI W K+ + + ++ +V + G+Y A N+ G + +TV
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE-TITQ 881
P P + + E V + + L P PSITW ++++ ++ ++ +
Sbjct: 1823 HVP------PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-ET 940
G +++ T ++ D+G Y CVA+N+AG++ + + V + ++ K ET
Sbjct: 1877 QSSGRVLQIAKTLLE---DAGRYTCVATNAAGETQQ--HIQLHVHEPPSLEDAGKMLNET 1931
Query: 941 E-EGKTVILECQTS-HTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
V LEC+ + + V WY + + +SG + G+ D G+
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS--DAGIY 1989
Query: 998 KCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDG 1053
KC+ + +T L + P V + LE E A + W +DG
Sbjct: 1990 KCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ N G I L + + + D G Y+C+ + + + + V +PP I+
Sbjct: 2050 SPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107
Query: 1111 TRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
QN V L + DA+ + W KDG + L+I + LKI
Sbjct: 2108 GEEQNVSVLISQAVEL---LCQSDAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKIE 2162
Query: 1167 DCDLDDAGEYSCEVGN--SKCTAILTVE---EPSINFTLRLPEFILVPANTDAYLTVEIP 1221
D + D G Y+CE N K V P+I + L + ++ N + L
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSG 2222
Query: 1222 DETLDVTWYKKKS-VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
++ W KK S V+ D+ + ++S R L I + D Y+CV + T K
Sbjct: 2223 IPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 1280 KVEV-VEFPPKIVD---YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ + V P I + + E + RG ++L + Q P P W+ + + K K +
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE 2340
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK----PNILE 1391
I + L +K + +D G Y N G D + ++++ PS G NI
Sbjct: 2341 --ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISV 2398
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRF 1451
++ +S+++ E +I ++ + +S+ N + + + L+ +
Sbjct: 2399 VEKNSVSLTC-EASGIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTME 2450
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVP 1509
A V + A E K+ + + P + E L+++ + + + LTC G P
Sbjct: 2451 DAGQYTCVVRNAAGEER---KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP 2507
Query: 1510 QPKVTWYRDGKKLKTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
P++TW++DG+ L+ +A + Y C+A + G S + +
Sbjct: 2508 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Query: 1568 QQKPVIT-ISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTK 1624
P I + ++ + V + V E PP + W+K+G LE+++ I
Sbjct: 2568 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2627
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+T ++I + ++ +Y+ A+N AG +KVY P +G + +S + V
Sbjct: 2628 GRT--LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVK 2685
Query: 1685 IEWKPPLDDGGLELTKYAI 1703
I+ L LE YAI
Sbjct: 2686 IKVNNTLT---LECEAYAI 2701
Score = 196 bits (477), Expect = 9e-49
Identities = 270/1212 (22%), Positives = 474/1212 (39%), Gaps = 118/1212 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 890
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 891 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 944
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 945 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 993
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P ++ G Y
Sbjct: 994 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYV 1050
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P + L ++ EI+V + L V P P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 1167
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXX 983
V ++ K + + G+ V + C T +K + + E
Sbjct: 1168 HVPPK--IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225
Query: 984 XXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILE 1037
D G+ C+ + ET L V+E P + L+ ++ VA
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQR 1283
Query: 1038 VEI-----NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
+E + + W +G + ++ + G + L I + + +D GEY C+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAV 1341
Query: 1093 DESCTAEVTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSE 1145
+E+ T E V +PP I + Q V N+ E+E T ++ W+KD +
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQ 1400
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLR 1201
+ S+ IQ +GK LK++ +DAG YSC+ G S+ + V P
Sbjct: 1401 VTESSTIQTVNNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 1202 LPEFILVPANTDAYLTVEIPDETL-DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P + V N D L ++ D+ W+K K + L+ + + L ++
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD--RGQVLHLKNAR 1516
Query: 1260 EDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFP 1315
+D+ Y C + +A K +K+ + PP I + + + S + L + + P
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKL-TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLP 1575
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W + + I ID K L I + + +D+ Y + N G A+ +V
Sbjct: 1576 MPAITWYKDGQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVK 1431
+ P G N+ + + I E + GN S I+ ++ + + +
Sbjct: 1634 DVYVPPMIEG--NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAND----- 1686
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLK 1489
NI + + + L+ S+ V S A E Y+V + P +E
Sbjct: 1687 NI-RIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETS 1742
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXX 1547
N +EL C G P P + W +DG+ + + N
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGL 1802
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C+A N G+ + V + P I S +E + K+K + + GIP P +
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSIT 1859
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+ + N + N+ + V++I + + +YT A+N AG + + L V++
Sbjct: 1860 WLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Query: 1666 PSKPEGPVIMRE 1677
PS + ++ E
Sbjct: 1919 PSLEDAGKMLNE 1930
Score = 193 bits (470), Expect = 7e-48
Identities = 242/1089 (22%), Positives = 423/1089 (38%), Gaps = 92/1089 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C + P I W G + + NI + L+I N ++ G Y+ VA
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGG------RTLQILNAQEDNAGRYSCVA 2648
Query: 713 VNREGEASLPIVLK------IKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
N GE +K I G+ P + P K + ++ ++ L + P ++
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPG-LSP-KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 767 TWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+W K+ +P+K+ + H++ I K ++ D G YT A N G E + ++ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQI-KEAQISDTGRYTCVASNIAGEDELDFDVNIQVP 2765
Query: 826 T--EENAEPPLFINRFQEITVKE---KGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
++ E ++ + K+ I L P P++TWY++ ++ S+ +
Sbjct: 2766 PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVL 2825
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS--HGARVTIDVEKVTFVKHLQKSY 938
G +++ V+ D+G Y CVA N AG+ S + RV + L +
Sbjct: 2826 ILPGGRVLQIPRAKVE---DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEV 2882
Query: 939 ETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
K+ ++EC +S + + + W + + + DH + + GR D+G
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGR 2940
Query: 997 IKCIVKDQETSTMLVVKETI---PEFIR-KLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
C+ ++ S + P I K ++ V + L E++ D+ W +
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPE 1108
+ + IK N G R L I V D GEY+CI +++ ++ V +PP
Sbjct: 3001 NEQPIKLNTNTL-IVPGG--RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 1109 IITR----LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
I L V +G + E E ++ W+K+G I S H+++ DG Q L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QML 3115
Query: 1164 KIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I ++ D G+Y C N K + PSI R E I+ + LT
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTC 3173
Query: 1219 E---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ IP T + W K IE+++ + L I + D YTC+ + +
Sbjct: 3174 DATGIPPPT--IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Query: 1276 TT-KLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
K ++ PP + E + + G +V L+ + P P +W+ + K I +
Sbjct: 3232 KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN---- 1388
+ + + ++L I +D G Y N G D N+ + P+ G +
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
++ + +SINI E TG W+ + I+ L
Sbjct: 3352 LMTLVDTSINI---ECRATGTPP-----------PQINWLKNGLPLPLSSHIRLLAAGQV 3397
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTC 1503
R V++V + + K +Q P ++ + + IT + C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 1504 IFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVET 1561
I G P P + W RDG+ L A T Y CIA N+ GEV
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3517
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
++ + + P I S E + V + +T + GIP P++ W K+G L + +
Sbjct: 3518 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--V 3575
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREIS 1679
T V+RI + + +YT AS+ AG E ++V+ P + + P + +
Sbjct: 3576 QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR 3635
Query: 1680 RESVTIEWK 1688
VT+E K
Sbjct: 3636 NRQVTLECK 3644
Score = 184 bits (449), Expect = 2e-45
Identities = 262/1206 (21%), Positives = 456/1206 (37%), Gaps = 135/1206 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G+ + C+ G P P + W ++ + ++ S + I E DA +
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE--KSDAALY 2267
Query: 582 TCVAKNAAGFASS--TTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
+CVA N AG A ++ + +++ GS T ++ +GIPP
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPP----- 2321
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P ++ +G ++ KG EI+ DE +L++ N
Sbjct: 2322 PTVTWMKDGHPLIKA---------------KGVEIL-DEG-------------HILQLKN 2352
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS---MIVRQGESVILSA 756
+ G Y VAVN G L + PP +I +S + V + SV L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHA----PPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ G P P+ITW K+ PV + + L ++D G YT N+ G
Sbjct: 2409 EASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK 2468
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
++V P E N +++ VKEK ++ L VT NPVP ITW+++ + +
Sbjct: 2469 IFGLSVLVPPHIVGE-----NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQED 2523
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E G ++ ITNV +G Y C+AS+ AG S + + V + +
Sbjct: 2524 EAHHIISGGRFLQ--ITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPT--IAGVGS 2578
Query: 937 SYETEEGKTVILECQTS--------HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
E+ TVIL TS + W+ + + + I+ GR
Sbjct: 2579 DGNPED-VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRK-------LQDFEVKEK--DVAILE 1037
+ G C+ ++ E VK IP I K L EVK K + LE
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1038 VEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
E + +A + W +DG+ +K + + GH L I+ + D G Y+C+ + +
Sbjct: 2696 CEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2752
Query: 1097 TAEVTV---VELPPEI--ITRLQNQKVNKGNKATFEIELTKGDAL-----------VRWF 1140
E+ +++PP + + N N ++ + +L + W+
Sbjct: 2753 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI 1196
KDG + S+ + + G+ L+I ++DAG Y+C E G + V P I
Sbjct: 2813 KDGHPLTSSDKVLILPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Query: 1197 --NFTLRLPEFILVPANTDAYL-TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
LPE + V N A + + +W K + + + +S+ R L
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSN--GRIL 2928
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE-YRIKRGSDVTLLVDY 1311
I D Y CV + + K + V PP ++ + E + + ++L +
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
FP P+ W+ N + IK +T I +L I + + +D G Y N G +
Sbjct: 2989 SGFPPPDLSWLKNEQPIK--LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWIS 1429
+ ++T+ PS I + DS S+++ N T + E + W
Sbjct: 3047 KFSLTVYVPPS------IKDHDSESLSVV-----NVREGTSVSLECESNAVPPPVITWYK 3095
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEK 1486
+ T ++ L + V++ + K + P++E
Sbjct: 3096 NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEG 3155
Query: 1487 PLKNITTEP-NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXX 1541
P + + E + + LTC G+P P + W ++ K+++ + +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ 3215
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y CIA N G+ + + IQ P + + +G+ + GIP
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W K+G + + + I S + I S + KYT A+N AG L
Sbjct: 3276 PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 1662 VYDKPS 1667
VY P+
Sbjct: 3336 VYVTPT 3341
Score = 180 bits (439), Expect = 4e-44
Identities = 241/1193 (20%), Positives = 429/1193 (35%), Gaps = 91/1193 (7%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+T+ EC+ P ++W++ +K + N TL I+E D G +TCV
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---NGHTLQIKEAQISDTGRYTCV 2746
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG ++ ++ P S ++L+ + +A+
Sbjct: 2747 ASNIAGEDELDFDVNIQVPPS-------------FQKLWEIGNMLDT-----GRNGEAKD 2788
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + I L C A P P + W G + + + + VL+I K
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG------RVLQIPRAKVED 2842
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G YT VAVN GE SL +++ + + + V +S ++ G+P P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAP 2902
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+W K+ +P+ I + ++ D G Y AEN+ G A+ + V
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV 2962
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P P + + + +TV I L V+ P P ++W +N + I +
Sbjct: 2963 P------PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG 3016
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET---E 941
G ++++ V D G+Y C+A N AG+S +T+ V + H +S
Sbjct: 3017 GRTLQIIRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPP-SIKDHDSESLSVVNVR 3072
Query: 942 EGKTVILECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
EG +V LEC+++ WY N + I+ H EI+ +G+ V +
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 1000 IV---KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
I +D + + V E + E V + + W ++ + I
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRL 1113
+ + + KL I + D G Y+CI + A+ +++PP +
Sbjct: 3193 E-NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 3251
Query: 1114 QNQKVNKGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
V+ E+ L++W KDG I ++ + L IY
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 1171 DDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D G+Y+C N + + P+I E ++ +T +
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 1226 -DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + + L++ + + I + D YTCV + +
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429
Query: 1285 EFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
F P +D E + +GS ++ P P+ W+ + + + H ++ +
Sbjct: 3430 VFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL--TVSTH 3487
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
L + K E D+G Y N G + +L+ P G EI S +N
Sbjct: 3488 GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVIVN--- 3543
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD- 1460
N T I + ++ W+ +Q L R V +
Sbjct: 3544 ----NPLELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGR 3596
Query: 1461 -----ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
S A + + Y V ++P ++IT N + L C VP P +TW
Sbjct: 3597 YTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 1516 YRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
R+G++L+ Y C+A N G+ ++ + P I
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNI 3715
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRI 1632
+ + + ++ + EG+P P + W K+G L N Y+I + + I
Sbjct: 3716 KGGPQSLVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---ENGFLHI 3770
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ + + +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 3823
Score = 178 bits (434), Expect = 2e-43
Identities = 266/1185 (22%), Positives = 444/1185 (37%), Gaps = 112/1185 (9%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
++ +C V G P P I W + +I F++ N LVI + + G + C+A
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL---NGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 587 NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ-YV 645
N AG DH E V +PPT ++ V
Sbjct: 1809 NTAG---------------DHKKEFEVTVH---------------VPPTIKSSGLSERVV 1838
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ + L+C IP P I WL K ++ V ++ I+S VL+I
Sbjct: 1839 VKYKPVALQCIANGIPNPSITWL-KDDQPVNTAQGNLKIQSSGR----VLQIAKTLLEDA 1893
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGESVILSAQVVGNPR 763
G YT VA N GE I L + EPP + + K + V V L + GNP
Sbjct: 1894 GRYTCVATNAAGETQQHIQLHVH----EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPV 1949
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P ITW K+N+ + + + + I ++ ++ D G+Y A NS G E + V
Sbjct: 1950 PVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVH 2009
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
P + V ++L P PS+TW ++ +S Q
Sbjct: 2010 -------VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL 2062
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
G I L +T+ D+G Y CVA N+AG+ + + V + S +
Sbjct: 2063 SGGRI-LALTSAQIS-DTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA 2120
Query: 944 KTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++ + + W + + I E R D G C +
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLS-ISENR-SVLKIEDAQVQDTGRYTCEATN 2178
Query: 1004 --QETSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEINS-ETADVVWERDGE-II 1056
+T V +P I +L V E ++ L E + +++W++ G ++
Sbjct: 2179 VAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRL 1113
+ G R+L I D YSC+ + + TA+ V + P I
Sbjct: 2239 TDSMGRVRILSGG--RQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSG 2296
Query: 1114 QNQK---VNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
+ V +G + E E+ V W KDG + + +++ +G +LK +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLK--NIH 2354
Query: 1170 LDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G Y C N K + PSI R PE I V LT E
Sbjct: 2355 VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIP 2414
Query: 1225 L-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK-STTKLKVE 1282
L +TW+K + + ++S R L + + T +D +YTCV+ +A K+
Sbjct: 2415 LPSITWFKDGWPVSLSNSVRILSG--GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 1283 VVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V PP IV + ++K VTL + P P W + + ++ + I S
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ--EDEAHHIIS 2530
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSS 1395
L I V+ G Y + GH ++ + P+ G P + + +
Sbjct: 2531 GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
S E + +TI ++ + +++ I + +T I N + +++ R+ A
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-KDGTPLESNRNIRILPGGRT-LQILNAQEDNAGRYSCVA 2648
Query: 1456 VNEV-DISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
NE ++ E Y +I + + P + K + + N + L C +P +
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSP--KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 1514 TWYRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+WY+DG+ LK+ N Y C+A N GE E V IQ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 1572 ----VITISNE-DIKQKHKVGDEWLVTAV-----IEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ I N D + + D + + PPP + WYK+G+ L + + I
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLI 2826
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ V++I K + +YT A N AG S++ ++V P
Sbjct: 2827 LPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Score = 176 bits (429), Expect = 6e-43
Identities = 262/1150 (22%), Positives = 439/1150 (38%), Gaps = 122/1150 (10%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLV 658
+ A +SD G T D+ +PP + + V + L C+
Sbjct: 2070 LTSAQISDTG-RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSD 2128
Query: 659 AIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE 718
AIP P + WL G ++ +S++ SVLKI + + G YT A N G+
Sbjct: 2129 AIPPPTLTWLKDGHPLLKKPGLSISENR------SVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 719 ASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
+ I PP + + L + V +G + L + G P P + W K PV
Sbjct: 2183 TEKNYNVNIWV----PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 777 A-----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE-EPTEENA 830
+ S G I+I + D +Y+ A N G A+ + V PT N+
Sbjct: 2239 TDSMGRVRILSGGRQLQISIAEK---SDAALYSCVASNVAGTAKKEYNLQVYIRPTITNS 2295
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
+ EI V +I L V P P++TW ++ + ++ + +G ++L
Sbjct: 2296 G-----SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQL 2350
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQ-KSYETEEGKTVILE 949
+V D+G Y CVA N AG + +++ H ++ E +V L
Sbjct: 2351 KNIHVS---DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 950 CQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--E 1005
C+ S S W+ + +S + I+ GR D G C+V++ E
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNSVRILSGGR--MLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 1006 TSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKN 1061
+ + +P I L+D +VKEK L E+ + ++ W +DG+ ++ +
Sbjct: 2466 ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDE 2524
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELP----------P 1107
+ G R L I N V G Y+C+ +S + + V P P
Sbjct: 2525 AHHIISGG--RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNP 2582
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
E +T + N + +A + A + WFKDG+ ++ + +I++ G+ L+I +
Sbjct: 2583 EDVTVILNSPTSLVCEA-----YSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 1168 CDLDDAGEYSCEVGNSKCTAILTVE-----EPSIN----FTLRL-PEFILVPANTDAYLT 1217
D+AG YSC N I E P IN + L P+ + + N L
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1218 VE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E IP +L +WYK ++ + + ++ TL I++ D YTCV +
Sbjct: 2696 CEAYAIPSASL--SWYKDGQPLKSDDHVNIAAN--GHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 1275 STTKLKVEV-VEFPP---------KIVDYEREYRIKR---GSDVTLLVDYQAFPQPNDEW 1321
+L +V ++ PP ++D R K + ++L + A P P W
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K I L I + + DAG Y N G ++ +V +L P
Sbjct: 2812 YKDGHPL--TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Query: 1382 SPPGKPNILE------IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK 1435
G + L ++ S++ C ++ E D +++S I +
Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQ 2929
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N + R+ A N A +Y+ + + + +N+T
Sbjct: 2930 ----ILNTQITDIGRYVCVAEN-----TAGSAKKYFNL--NVHVPPSVIGPKSENLTVVV 2978
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
N I LTC G P P ++W ++ + KL T Y CIA
Sbjct: 2979 NNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGN 1611
N GE + + + P I + + V + V+ E +PPP + WYKNG
Sbjct: 3039 NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGR 3098
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS--KP 1669
+ I + ++ IK+ + S + +Y A N AG L VY PS P
Sbjct: 3099 MITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGP 3156
Query: 1670 EGPVIMREIS 1679
E VI+ IS
Sbjct: 3157 EREVIVETIS 3166
Score = 173 bits (422), Expect = 4e-42
Identities = 232/1115 (20%), Positives = 425/1115 (38%), Gaps = 83/1115 (7%)
Query: 594 STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL 653
S L +E G E T ++ + PT + EG + L
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTL 1000
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C+ P+P + W KGE ++ + + +D +Y + + + G Y A
Sbjct: 1001 PCKASGNPKPSVIWSKKGE-LISTSSAKFSAGADGSLY-----VVSPGGEESGEYVCTAT 1054
Query: 714 NREGEASLPIVLKIKT-----GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
N G A + L + G++ +P++ ++ GE V L +V P P ITW
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITW 1113
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
K + + + + + D G+Y A N G + + V P +
Sbjct: 1114 AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNFDGEN 887
P + ++ V ++ I A+ T P+P ITW + ++ E N DG
Sbjct: 1174 QRGP-----KHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHHVSNPDGT- 1225
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE-----E 942
L I D+G Y CVA+N AG +T+ V++ V+ L+ Y T
Sbjct: 1226 --LSIDQATPS-DAGIYTCVATNIAGTDE--TEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 943 GKTVILECQTSHTV--STKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ + C T + KW HN +E++G + I+++G D G C
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG--TLLVIASVTPYDNGEYIC 1338
Query: 1000 IVKDQETST--MLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVV-WERDG 1053
+ ++ +T +K +P I+ ++ + V + L E+ + ++ W +D
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ + + G I KL+ + D G YSC + + T++ V +PP II
Sbjct: 1399 VQVT-ESSTIQTVNNGKILKLF--RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 1111 -TRLQNQ-KVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T N+ V E ++ KG + WFKDG + F + + + Q L +
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLK 1513
Query: 1167 DCDLDDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
+ +D G Y C V N+ LT+ P + I V N+ L E
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 1223 ETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ +TWYK I + + I K + L I + D YTC + + T +
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Query: 1282 EVVEFPPKIVDYEREYRIKR----GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V + P +++ + + +TL P P W+ + +K + +
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-- 1689
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
I++ L I + D G Y + G +++ V +L P+ G
Sbjct: 1690 IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 1398 NICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
N+ + TG+ I ++ + Q ID + + + + I + +++ +R A
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N ++ K + T PT++ L + + L CI G+P P +TW
Sbjct: 1809 NTAG--------DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW 1860
Query: 1516 YRDGKKLKTAKATYENRXX---XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+D + + TA+ + + Y C+A N GE + + + + P
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + + + + V + + G P P + WYK+ L ++T + +I I
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGST--SMTFLNRGQIIDI 1978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + S + Y A N+AG + + +L+V+ PS
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 173 bits (421), Expect = 6e-42
Identities = 252/1208 (20%), Positives = 458/1208 (37%), Gaps = 111/1208 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S C+ YP ITWF+ ++ +++ ++ TL I ++AG ++CV
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PGGRTLQILNAQEDNAGRYSCV 2647
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG E+ V P + ++ P S PK
Sbjct: 2648 ATNEAGEMIKHYEVKVYIPPIINKGDLW--------------------GPGLS--PKEVK 2685
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+ + + LEC AIP ++W G+ + D+++++A L+I +
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH------TLQIKEAQISD 2739
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP--QVIEPLKSMIV--RQGES--------V 752
G YT VA N GE L + I+ PP Q + + +M+ R GE+ +
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNIQV----PPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L + P PT+TW K+ P+ + + + KV+D G YT A N G
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Query: 813 IAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ V P N++ P +E+TV + + + +P P +W ++
Sbjct: 2856 EDSLQYDVRVLVPPIIKGANSDLP------EEVTVLVNKSALIECLSSGSPAPRNSWQKD 2909
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + + +G ++++ T + D G Y CVA N+AG + + + V +
Sbjct: 2910 GQPLLEDDHHKFLSNGRILQILNTQIT---DIGRYVCVAENTAGSAKKYFNLNVHVPP-S 2965
Query: 930 FVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ ++ + L C+ S W N++ I + I+ GR
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 988 XXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR-----KLQDFEVKEKDVAILEVEI 1040
D G CI +Q E+ + +P I+ L V+E LE E
Sbjct: 3026 KVS--DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES 3083
Query: 1041 NSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N+ V+ W ++G +I + E + L+I+ V D G+Y C + + +
Sbjct: 3084 NAVPPPVITWYKNGRMITESTH---VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Query: 1100 VTV---VELPPEIITRLQNQKVNK-GNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQL 1154
V +PP I + V N T + T + W K+ I+ S+ +++
Sbjct: 3141 KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEV 3200
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPA 1210
I KL+I D+G Y+C N + A L+++ P +P + V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL 3260
Query: 1211 NTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ L T + W K I E + TL I D +YTCV
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--PQPNDEWIVNS 1325
+ + + V P + + ++ D ++ ++ +A P P W+ N
Sbjct: 3321 ATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP- 1384
+ H + + + + I + + +D +Y N G + N+ + P+
Sbjct: 3381 LPLPLSSHIR--LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDN 3438
Query: 1385 --GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
G I + SS ++ S + ++ + Q + ++V +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMV-LQLLK 3495
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYY--KVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+T S ++ A NE A E ++++ KV++ I + + I P +E
Sbjct: 3496 AETEDSGKYTCIASNE-----AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP---LE 3547
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
LTCI G+P PK+TW +DG+ L T Y C+A + G+
Sbjct: 3548 LTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGD 3607
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ +V + P I ++E + + + +PPP + W +NG +L+
Sbjct: 3608 DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR 3667
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
I + + ++I ++ YT ASN AG ++ E L V P+ GP + +
Sbjct: 3668 VRILSGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVIL 3725
Query: 1679 SRESVTIE 1686
+S +E
Sbjct: 3726 LNKSTVLE 3733
Score = 165 bits (402), Expect = 1e-39
Identities = 238/1078 (22%), Positives = 414/1078 (38%), Gaps = 81/1078 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 847
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 906
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 962
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 1015 SKKGELISTSSAKFSAGADG---SLYVVSPGGE-ESGEYVCTATNTAGYAKRKVQLTVYV 1070
Query: 926 EKVTF--VKHLQKSYETE----EGKTVILECQTSHTVS--TKWYHNKKEISGMDHREIIQ 977
F + L + E G+ V L C+ W + IS R
Sbjct: 1071 RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL 1130
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVA 1034
D G+ C+ + + VK + P+ R + +V+
Sbjct: 1131 P--SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ V+ W + G + + G L I + D G Y+C+ +
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATN 1245
Query: 1094 ESCTAEV----------TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ T E TV +L P T Q + N+ + + T ++W +G
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KPTIKWLHNG 1304
Query: 1144 SEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
E+ I + DG L I D GEY C E G ++ L V P +
Sbjct: 1305 RELTGREPGISILEDG--TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIK 1362
Query: 1199 TLRLPEFILVPAN--TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIR 1256
+ V N T+ + VE + + WYK ++ TE T+ + + L +
Sbjct: 1363 DKEQVTNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDN--VQVTESSTIQTVNNGKILKLF 1419
Query: 1257 KCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQA 1313
+ T +D Y+C ++ T++ + V PP I+ ++ E + DV L +
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKG 1479
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P P+ W + K + +D + L +K D G Y+ + N G ++
Sbjct: 1480 TPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+TI PS G +I ++ E E G I + + Q I ++
Sbjct: 1539 KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS--QALY 1596
Query: 1433 ITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
I K Q I + + S + + N ++ +E + + V I+ + PL N
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVAN---VAGTAEKSFHVDVYVPPMIEG-NLATPL-NK 1651
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYK 1549
+ L C G P P +TW +DG +K Y
Sbjct: 1652 QVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYI 1711
Query: 1550 CIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
C+A + GE E V + P I +E V + + + G PPP ++W K+
Sbjct: 1712 CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD 1771
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
G ++ + I + V I + + S++ Y A+NTAG E + V+ P+
Sbjct: 1772 GQLIDERDGFKILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 164 bits (399), Expect = 3e-39
Identities = 241/1072 (22%), Positives = 409/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 3301
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M +
Sbjct: 3302 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD- 3357
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 3358 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 3418 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 3473 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 3524
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3584
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 3585 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3699
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 3757
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 3758 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 3813
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3871
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 3932 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 3989
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 3990 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 4040
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 4159 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 4214
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 4215 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4266
Score = 160 bits (389), Expect = 4e-38
Identities = 222/1029 (21%), Positives = 397/1029 (38%), Gaps = 84/1029 (8%)
Query: 680 ISVAIESDMHMYCSV-LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+++ ++ + SV L I V EG Y +AV+ G + EPP VI
Sbjct: 468 VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS----EPPPVI 523
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKV 797
+ ++ V GE +L+ ++ +TW +N++ V+ A P + + LK K
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF 583
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y + G + S +TV+EP + P + Q T + + ++ T
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP-----KNQSFTGGSE--VSIMCSAT 636
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P I W N+ I S DG L I N + D+G Y C+ASNSAG
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG---TLFIKNAAPK-DAGIYGCLASNSAGTDKQ 692
Query: 918 GARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHRE 974
+ + I+ K+ V Q G ++EC+TS KW+ E+
Sbjct: 693 NSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF-- 747
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+I + D G C+ ++ T + + + P FI++ D ++
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807
Query: 1032 DVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
L + + W R D I + + L+I N D+G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 1090 ILRDE--SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDALV--RWFKD 1142
++ +E TV + P I V +G + T L G+ + RW K+
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-----NSKCTAILTVEEPSIN 1197
+ + + +I + DG L I L D GEY+C N+K T+++ P+I
Sbjct: 928 SAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 1198 FTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLII 1255
++ I +P + + V W KK +I + KF+ +D +L +
Sbjct: 985 HGQQILSTIEGIPVTLPCKAS---GNPKPSVIWSKKGELISTSSAKFSAGAD---GSLYV 1038
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER--------EYRIKRGSDVT 1306
++ EY C + K KV++ V P++ +R E + G +VT
Sbjct: 1039 VSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
L + ++ P P W +++I + S S+ I + +D+G+Y N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKITETRTSDSGMYLCVATNIA 1156
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G+ + + + P P L++ + D P N + + V+ + + +T
Sbjct: 1157 GNVTQAVKLNVHVPPKIQRGPKHLKV---QVGQRVDIPCNAQGTPL--PVITWSKGGSTM 1211
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE- 1485
+ ++ ++ + Y +I+ E TE ++E PTVE
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE-TEITLHVQE----PPTVED 1266
Query: 1486 -KPLKNITTE---PNEDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXX 1538
+P N T + N+ IE C G P+P + W +G++L + + E+
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIA 1326
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N+ G E + + PVI + + + +EG
Sbjct: 1327 SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P ++WYK + ++ + I T ++++ + +Y+ +A N AGTS
Sbjct: 1387 TPSPIIMWYK--DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 1659 TLKVYDKPS 1667
+ V P+
Sbjct: 1445 NIDVLVPPT 1453
Score = 151 bits (367), Expect = 2e-35
Identities = 241/1167 (20%), Positives = 421/1167 (36%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 3506
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 3561
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 3562 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 3592
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 3593 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 3647
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 3648 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 3708 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 3760
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 3761 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 3817
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 3878 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 3937
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 3938 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3994
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4050
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 4106
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S +L I D YTC+ + S+T K
Sbjct: 4107 PPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4162
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 4163 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 4218
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 4219 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 4267
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 4268 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4324
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K I ++ P V K + EP + L C G P P + W
Sbjct: 4325 TYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN 4384
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 4445 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 4499
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 4500 QKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 149 bits (362), Expect = 8e-35
Identities = 233/1097 (21%), Positives = 389/1097 (35%), Gaps = 84/1097 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + PK Q GS++ + C P+P IAW IV + SD
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT--SD----- 663
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N G Y +A N G L+ E P+++ ++V G+
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRY----IEAPKLMVVQSELLVALGDIT 719
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G P P + W K + ++ + ++ + D G YT A N G
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NN 870
A + V PP+FI +++++ + L V P P+I W R N
Sbjct: 780 RATGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I S +++ L I N+ + D G Y C A N GK VT+
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ EG+ + L C + +W N + + + +G
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
+ + V T VV +P Q E L + + +
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPS 1011
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
V+W + GE+I K+ G LY+ + + GEY C + + A+ V V
Sbjct: 1012 VIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 1104 ELPPEII---TRLQNQK-----VNKGNKATFEIEL-TKGDALVRWFKDGSEIQ-FSNHIQ 1153
+ P + L K V G + T E+ + ++ W K+ I FS
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHT 1128
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
G +KI + D+G Y C GN L V P R P+ + V
Sbjct: 1129 FLPSG---SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP--KIQRGPKHLKVQ 1183
Query: 1210 ANTDAYLTVEIPDETLDV-TWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L V TW K S ++ D E D TL I + T D YT
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATPSDAGIYT 1240
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIK-----RGSDVTLLVDYQAFPQPNDEW 1321
CV + T + ++ + V+ PP + D E Y + + P+P +W
Sbjct: 1241 CVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW 1300
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ N + + + SI L I V D G Y N G + + N+ + P
Sbjct: 1301 LHNGRELTG-REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Query: 1382 SPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
K + + + + + E E T + I++Y + TE +++ + +
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQVTESSTIQTVNNGK-- 1414
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNED 1498
I L + Y+ ++I+ S+ +Y+ + + + + N ++ N D
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQ--KYFNI--DVLVPPTIIGTNFPNEVSVVLNRD 1470
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCIAFND 1555
+ L C G P P + W++DGK L E Y+C N
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G+ + I P I N + + G+P P + WYK+G + +
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG---- 1671
+ +K + I + S S+ YT +N AGT+ + VY P EG
Sbjct: 1591 SSQ--ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY-VPPMIEGNLAT 1647
Query: 1672 PVIMREISRESVTIEWK 1688
P+ + + S+T+E K
Sbjct: 1648 PLNKQVVIAHSLTLECK 1664
Score = 147 bits (356), Expect = 4e-34
Identities = 238/1118 (21%), Positives = 422/1118 (37%), Gaps = 93/1118 (8%)
Query: 599 IVEAPLSDHGS-EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
I + LSD G E D+ E PP + P V G +L C +
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
++ + ++ W ++ E + +++ L++ +VK G Y + + G
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-----LELKSVKFNDAGEYHCMVSSEGG 598
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA 777
++ + L + +EPP+V K+ G V + G P+P I W N+ +
Sbjct: 599 SSAASVFLTV----QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 778 LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-AETSAVITVEEPTEENAEPPLFI 836
+ + +K KD G+Y A NS G + S + +E P + L +
Sbjct: 655 -SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLV 713
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
+ITV E + + P P + W++ + + PS + + + L+
Sbjct: 714 -ALGDITVME-------CKTSGIPPPQVKWFKGDLELRPSTFLIID---PLLGLLKIQET 762
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSH 954
++D+GDY CVA N AG+++ ++T+DV E G V L C Q
Sbjct: 763 QDLDAGDYTCVAINEAGRAT--GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Query: 955 TVSTKW--YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETST 1008
+ KW N S I + R D G C ++Q ++ T
Sbjct: 821 EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 1009 MLVVKETIPEFIRKLQDF-EVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDF 1065
+ V + I V E L + + + W ++ ++ +N Y
Sbjct: 881 TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML--LQNPYIT 938
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITRLQNQKVNKGN 1122
+ L+I + D GEY+C+ + + T T VV + P I Q +G
Sbjct: 939 VRSD--GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + V W K G I S+ DG L + +++GEY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTA 1053
Query: 1179 --EVGNSKCTAILTV-EEPSI-----NFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTW 1229
G +K LTV P + + P I V A + L E+ +TW
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 1230 YKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
K+ +I + + T + ++ I + D Y CV + V++ V P
Sbjct: 1114 AKETQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLT 1346
PKI + +++ G V + + Q P P W S ++ +H + + +L+
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEH---HVSNPDGTLS 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSSSINICW 1401
I + +DAGIY N G + E+ + + + P+ PP E ++ I +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-RIEF 1286
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
P I ++ +E+ E IS+ T I ++ + + AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILE-DGTLLVIASVTPYDNGEYICVAVNE-- 1343
Query: 1461 ISDASETTEYYKVIKETKIQSPTV---EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
A T Y + K+ P V ++ + N++ N+ L C G P P + WY+
Sbjct: 1344 ---AGTTERKYNL----KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Query: 1518 DGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
D ++ + T N Y C A N G + + + P I
Sbjct: 1397 DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
+N + + + + ++G P P++ W+K+G L + N+ ++ V+ +K
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
+R+ +Y SN AG + ++ L +Y PS G V
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553
Score = 121 bits (291), Expect = 3e-26
Identities = 205/965 (21%), Positives = 343/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 3618 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 3674
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 3675 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 3727
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 3728 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 3787
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 3788 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 3898
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 3899 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 4018 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 4074
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 4075 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 4131
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 4132 S---LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 4185
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 4242
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 4243 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 4302
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P +
Sbjct: 4303 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP-------VF 4351
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ D S W EP G + I+ V+ T +W + I+ L S
Sbjct: 4352 KGDYPS---NWIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS--- 4403
Query: 1451 FRAYAVNEVDISD-ASETTEYYKVIKET---KIQSPTV--EKPLKNITTEPNEDIELTCI 1504
Y D D T V++ + +QSP + +P++ + + I L C
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK-IILNCQ 4462
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 4523 PVIVQ 4527
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C GYP+P+I W I S ++M D TL I+ P+DAG + C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD----GTLFIKNAAPKDAGIYGC 681
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+A N+AG + L +EAP
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP 702
Score = 51.6 bits (118), Expect = 3e-05
Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V EC+ P P ITW++ +I S ++ D L I++
Sbjct: 3064 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 3120
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 3179
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 3180 PPTIAWLKNHKRIENSD-SLEVRILS 3204
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 773 VAINEAGRATGKITLDVGSP 792
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 489 NEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
++K ++ V PT + ++ V K +P V +C G P P ITW +
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKP--------VALQCIANGIPNPSITWLKDDQ 1865
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +Q V L I + EDAG +TCVA NAAG +L V P S
Sbjct: 1866 PVNTAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 4313
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF + + V+ P
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Score = 47.2 bits (107), Expect = 6e-04
Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 1658
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC+ G P P +TW + +K + + ++ + + +E+ D G + CVA
Sbjct: 1659 LTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT 1715
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q +
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI 1775
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVS 1798
Score = 47.2 bits (107), Expect = 6e-04
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G C+V+G P P I W R+ I+ S + + +L I EDAG +
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVNEDAGDY 4417
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA N AG + L +++P
Sbjct: 4418 TCVATNEAGVVERSMSLTLQSP 4439
Score = 45.6 bits (103), Expect = 0.002
Identities = 38/185 (20%), Positives = 69/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ V +++ PV + +G ++ ++G P
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFK-GDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 4379 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 1662 VYDKP 1666
+ P
Sbjct: 4436 LQSPP 4440
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 4239 CVANNAAGEDTHTVSLTV 4256
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 4044
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 4454 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 4509
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 4510 VARNLMGSVLVRVPVIVQ 4527
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 3910 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 3962
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 3963 GRYTCVARNAAGSAHRHVTLHVHEP 3987
>AL391824-1|CAI17865.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-268N14 on chromosome 1. ).
Length = 5635
Score = 235 bits (574), Expect = 2e-60
Identities = 291/1201 (24%), Positives = 482/1201 (40%), Gaps = 129/1201 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ EC+V+G P P +TW + + ++ ++ D+ ++ L ++ + D G + C
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHI--LQLKNIHVSDTGRYVC 2363
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA N AG +L V AP S G+ + P S
Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRS--------------------PENIS------ 2397
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V E + + L C IP P I W FK V N SV I S M L++
Sbjct: 2398 -VVEKNSVSLTCEASGIPLPSITW-FKDGWPVSLSN-SVRILSGGRM----LRLMQTTME 2450
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGN 761
G YT V N GE L + PP ++ L+ + V++ +SV L+ +V GN
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLV----PPHIVGENTLEDVKVKEKQSVTLTCEVTGN 2506
Query: 762 PRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P ITW K+ +P+ +A S G IT + +V G YT A + G S
Sbjct: 2507 PVPEITWHKDGQPLQEDEAHHIISGGRFLQITNV---QVPHTGRYTCLASSPAGHKSRSF 2563
Query: 819 VITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+ V PT +++TV LV P +ITW+++ + +
Sbjct: 2564 SLNVFVSPTIAGVGSD---GNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2620
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL--- 934
I G ++++ D ++G Y CVA+N AG+ V + + + L
Sbjct: 2621 NIRILPGGRTLQILNAQED---NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGP 2677
Query: 935 ---QKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
K + + T+ LEC+ + S WY + + + DH I G
Sbjct: 2678 GLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2735
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIRKLQDF--------EVKEKDVAI---- 1035
D G C+ + E V +P +KL + + KDV I
Sbjct: 2736 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 1036 -LEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L E N + + W +DG + +K G R L I V D G Y+C+ +
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPL-TSSDKVLILPGG--RVLQIPRAKVEDAGRYTCVAVN 2852
Query: 1094 ES--CTAEVTVVELPPEII----TRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSE 1145
E+ + + V L P II + L + NK+ L+ G R W KDG
Sbjct: 2853 EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2912
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
+ +H + +G+ L+I + + D G Y C G++K L V P +
Sbjct: 2913 LLEDDHHKFLSNGR--ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970
Query: 1202 LPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E + V N LT E+ D++W K + I+ ++ RTL I +
Sbjct: 2971 -SENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG--GRTLQIIRAKV 3027
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE----YRIKRGSDVTLLVDYQAFP 1315
D EYTC+ ++ +K K + V PP I D++ E ++ G+ V+L + A P
Sbjct: 3028 SDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W N ++I + H + D + L IKK E +D G Y R N G D ++
Sbjct: 3088 PPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145
Query: 1376 TILDKPS--PPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+ PS P + I+E S+ + + D TG I ++ ++ I+ ++ + V+
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDA---TGIPPPTIAWLKNHKRIENSDSLEVRI 3202
Query: 1433 IT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
++ ++ I + + S + A N + +YY + + E P ++
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNM-----EGKAQKYYFLSIQVPPSVAGAEIP-SDV 3256
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXXXXXXXX 1547
+ E++EL C G+P P + W +DGK + + + N
Sbjct: 3257 SVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3316
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIW 1606
Y C+A N GE + + + P I + ++ ++ + D + + G PPP++ W
Sbjct: 3317 YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW 3376
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
KNG L + + VIRI + S + YT ASN AG + L+V+ P
Sbjct: 3377 LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPP 3434
Query: 1667 S 1667
+
Sbjct: 3435 N 3435
Score = 215 bits (525), Expect = 1e-54
Identities = 273/1202 (22%), Positives = 469/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 1027
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 1082
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 1083 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 1125
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA N G + + L + PP++
Sbjct: 1126 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV----PPKIQR 1175
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 800 EGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+E PT E+ EPP + FQE ++ A+ T
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 1293
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + + LVI +V + D+G+Y CVA N AG +
Sbjct: 1294 -PKPTIKWLHNGRELTGREPGISILEDGTL-LVIASV-TPYDNGEYICVAVNEAGTTERK 1350
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 1351 YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTM-----LVVKETIPEFIRKLQDFEVKE 1030
G+ D G C + TS ++V TI + V
Sbjct: 1411 NNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN 1468
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ + D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 1469 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 1525
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 1586 QPIMSSSQ-ALYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 1638
Query: 1204 EFI----LVPANTDAY----LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + + + KK
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK-- 1696
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLV 1309
L I E D+ +Y CV ++K EV V PP I D + + + + L
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + ++I + K ++ + + +V NT G+Y+ N G
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 1814
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 1815 KKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQ--- 1871
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 1872 -GNL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 1926
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR-XXXXXXXXXXXXX 1545
N T + ++L C G P P +TWY+D + L + T+ NR
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDA 1986
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLT 2044
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 2045 WLKDGSPVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 1666 PS 1667
P+
Sbjct: 2104 PN 2105
Score = 209 bits (511), Expect = 7e-53
Identities = 270/1179 (22%), Positives = 456/1179 (38%), Gaps = 93/1179 (7%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 1233
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 1234 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTVE------------DLEPPYNTT 1274
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F ++ Q ++ C P+P I WL G E+ E ++I D ++L
Sbjct: 1275 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREP-GISILEDG----TLL 1323
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVI 753
I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVTNVSVLLNQLTN 1379
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439
Query: 814 AETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
++ I V P P + F E++V + L +V P P I W+++ +
Sbjct: 1440 SQKYFNIDVLVP------PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 1494 LFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Query: 933 HLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ + LEC+T + WY + + I I +G+
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611
Query: 991 XXDVGVIKCIVKDQETST--MLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-- 1046
D C V + + V +P I + ++ V + + + A
Sbjct: 1612 --DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNP 1669
Query: 1047 ---VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
+ W +DG +K N E G +KL I + D G+Y C+ + E+
Sbjct: 1670 SPILTWLKDGVPVKANDN-IRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYE 1726
Query: 1103 --VELPPEIITRLQNQK--VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
V +PP I + V N + +T + W KDG I + ++ ++
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLN 1786
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVPANTD 1213
G+K L I + + G Y C N+ K +TV P + L E ++V
Sbjct: 1787 GRK--LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
A + +TW K + +T + L R L I K +D YTCV +A
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903
Query: 1274 KSTTKLKVEV-VEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
T+ +++ V PP + D + + + V L P P W +++++
Sbjct: 1904 AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSG 1963
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N++
Sbjct: 1964 S--TSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMV 2021
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ ++ E ++ + + + V + + ++ + + + + R
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQISDTGR 2080
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 2081 YTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Query: 1511 PKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
P +TW +DG L K + ENR Y C A N G+ E + V I
Sbjct: 2133 PTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW 2192
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I S+E + G+ + GIPPP +IW K G+ + D +
Sbjct: 2193 VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR 2252
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++I ++S ++ Y+ ASN AGT+ E L+VY +P+
Sbjct: 2253 QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPT 2291
Score = 200 bits (488), Expect = 4e-50
Identities = 249/1088 (22%), Positives = 430/1088 (39%), Gaps = 92/1088 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+ S V + + LEC IP P + WL G + N +
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+L +T+ + G YT VAVN GE I L++ PP ++ +++ V ++
Sbjct: 2067 --ILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV----PPNIMGEEQNVSVLISQA 2120
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
V L Q P PT+TW K+ P+ P S + S+ ++ +V+D G YT +A N
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YRNN 870
G E + + + P L ++TV E I L+ + P P++ W + +
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIWKKKGS 2235
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKV 928
+++ S + G +L I ++ + D+ Y CVASN AG K + +V I
Sbjct: 2236 PVLTDSMGRVRILSGGR-QLQI-SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTIT 2293
Query: 929 TFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
H + T GK++ LEC+ + W + + EI+ EG
Sbjct: 2294 NSGSHPTEIIVT-RGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQL 2350
Query: 987 XXXXXXDVGVIKCI------VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + D++ + +I R ++ V EK+ L E
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 1041 NS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ESC 1096
+ + W +DG + N G R L + T++ D G+Y+C++R+ E
Sbjct: 2411 SGIPLPSITWFKDGWPVS-LSNSVRILSGG--RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467
Query: 1097 TAEVTVVELPPEII--TRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQ 1153
V +PP I+ L++ KV + T E+T + W KDG +Q
Sbjct: 2468 KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHH 2527
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSIN--FTLRLPEFI 1206
+ G+ L+I + + G Y+C + S+ ++ P+I + PE +
Sbjct: 2528 IISGGR--FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV 2585
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V N+ L E +TW+K + +E ++ RTL I ED+
Sbjct: 2586 TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG--GRTLQILNAQEDNAGR 2643
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVD---------YEREYRIKRGSDVTLLVDYQAFPQ 1316
Y+CV + EV + P I++ +E +IK + +TL + A P
Sbjct: 2644 YSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPS 2703
Query: 1317 PNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+ W + + +K H +I + +L IK+ + +D G Y N G +++ +V
Sbjct: 2704 ASLSWYKDGQPLKSDDHV--NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVN 2761
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENT--GNSTIIYYVVEYQEIDTTEWISVKN-I 1433
I PP + EI + E ++ N +Y T W + +
Sbjct: 2762 I---QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 1434 TKTQ----------TSIQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQSP 1482
T + I K + R+ AVNE ++ +Y +V+ I+
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA----GEDSLQYDVRVLVPPIIKGA 2874
Query: 1483 TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXX 1540
+ P + +T N+ + C+ G P P+ +W +DG+ L N
Sbjct: 2875 NSDLP-EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQKP-VITISNEDIKQKHKVGDEWLVTAVIEGI 1599
Y C+A N G + + + P VI +E++ V + +T + G
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV--VVNNFISLTCEVSGF 2991
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
PPP++ W KN ++ + I +T ++I K S +YT A N AG S + +
Sbjct: 2992 PPPDLSWLKNEQPIKLNTNTLIVPGGRT--LQIIRAKVSDGGEYTCIAINQAGESKKKFS 3049
Query: 1660 LKVYDKPS 1667
L VY PS
Sbjct: 3050 LTVYVPPS 3057
Score = 197 bits (481), Expect = 3e-49
Identities = 269/1219 (22%), Positives = 480/1219 (39%), Gaps = 120/1219 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S ++ EC+ G P P ITW++ I S +Y D + +V D+ T+TC
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQ-ALYIDKGQYLHIPRAQV--SDSATYTCH 1619
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
N AG A + + V P ++EG T P +
Sbjct: 1620 VANVAGTAEKSFHVDVYVP-----------------------PMIEGNLAT----PLNKQ 1652
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + LEC+ P P + WL G + ++NI + L+I + ++
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK------LEIMSAQEID 1706
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGNP 762
G Y VA + GE + K + PP + + IV + L V G+P
Sbjct: 1707 RGQYICVATSVAGEKEI----KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 763 RPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
PTI W K+ + + ++ +V + G+Y A N+ G + +TV
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE-TITQ 881
P P + + E V + + L P PSITW ++++ ++ ++ +
Sbjct: 1823 HVP------PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-ET 940
G +++ T ++ D+G Y CVA+N+AG++ + + V + ++ K ET
Sbjct: 1877 QSSGRVLQIAKTLLE---DAGRYTCVATNAAGETQQ--HIQLHVHEPPSLEDAGKMLNET 1931
Query: 941 E-EGKTVILECQTS-HTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
V LEC+ + + V WY + + +SG + G+ D G+
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS--DAGIY 1989
Query: 998 KCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDG 1053
KC+ + +T L + P V + LE E A + W +DG
Sbjct: 1990 KCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ N G I L + + + D G Y+C+ + + + + V +PP I+
Sbjct: 2050 SPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107
Query: 1111 TRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
QN V L + DA+ + W KDG + L+I + LKI
Sbjct: 2108 GEEQNVSVLISQAVEL---LCQSDAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKIE 2162
Query: 1167 DCDLDDAGEYSCEVGN--SKCTAILTVE---EPSINFTLRLPEFILVPANTDAYLTVEIP 1221
D + D G Y+CE N K V P+I + L + ++ N + L
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSG 2222
Query: 1222 DETLDVTWYKKKS-VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
++ W KK S V+ D+ + ++S R L I + D Y+CV + T K
Sbjct: 2223 IPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 1280 KVEV-VEFPPKIVD---YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ + V P I + + E + RG ++L + Q P P W+ + + K K +
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE 2340
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK----PNILE 1391
I + L +K + +D G Y N G D + ++++ PS G NI
Sbjct: 2341 --ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISV 2398
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRF 1451
++ +S+++ E +I ++ + +S+ N + + + L+ +
Sbjct: 2399 VEKNSVSLTC-EASGIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTME 2450
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVP 1509
A V + A E K+ + + P + E L+++ + + + LTC G P
Sbjct: 2451 DAGQYTCVVRNAAGEER---KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP 2507
Query: 1510 QPKVTWYRDGKKLKTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
P++TW++DG+ L+ +A + Y C+A + G S + +
Sbjct: 2508 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Query: 1568 QQKPVIT-ISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTK 1624
P I + ++ + V + V E PP + W+K+G LE+++ I
Sbjct: 2568 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2627
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+T ++I + ++ +Y+ A+N AG +KVY P +G + +S + V
Sbjct: 2628 GRT--LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVK 2685
Query: 1685 IEWKPPLDDGGLELTKYAI 1703
I+ L LE YAI
Sbjct: 2686 IKVNNTLT---LECEAYAI 2701
Score = 196 bits (477), Expect = 9e-49
Identities = 270/1212 (22%), Positives = 474/1212 (39%), Gaps = 118/1212 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 890
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 891 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 944
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 945 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 993
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P ++ G Y
Sbjct: 994 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYV 1050
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P + L ++ EI+V + L V P P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 1167
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXX 983
V ++ K + + G+ V + C T +K + + E
Sbjct: 1168 HVPPK--IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225
Query: 984 XXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILE 1037
D G+ C+ + ET L V+E P + L+ ++ VA
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQR 1283
Query: 1038 VEI-----NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
+E + + W +G + ++ + G + L I + + +D GEY C+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAV 1341
Query: 1093 DESCTAEVTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSE 1145
+E+ T E V +PP I + Q V N+ E+E T ++ W+KD +
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQ 1400
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLR 1201
+ S+ IQ +GK LK++ +DAG YSC+ G S+ + V P
Sbjct: 1401 VTESSTIQTVNNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 1202 LPEFILVPANTDAYLTVEIPDETL-DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P + V N D L ++ D+ W+K K + L+ + + L ++
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD--RGQVLHLKNAR 1516
Query: 1260 EDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFP 1315
+D+ Y C + +A K +K+ + PP I + + + S + L + + P
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKL-TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLP 1575
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W + + I ID K L I + + +D+ Y + N G A+ +V
Sbjct: 1576 MPAITWYKDGQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVK 1431
+ P G N+ + + I E + GN S I+ ++ + + +
Sbjct: 1634 DVYVPPMIEG--NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAND----- 1686
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLK 1489
NI + + + L+ S+ V S A E Y+V + P +E
Sbjct: 1687 NI-RIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETS 1742
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXX 1547
N +EL C G P P + W +DG+ + + N
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGL 1802
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C+A N G+ + V + P I S +E + K+K + + GIP P +
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSIT 1859
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+ + N + N+ + V++I + + +YT A+N AG + + L V++
Sbjct: 1860 WLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Query: 1666 PSKPEGPVIMRE 1677
PS + ++ E
Sbjct: 1919 PSLEDAGKMLNE 1930
Score = 193 bits (470), Expect = 7e-48
Identities = 242/1089 (22%), Positives = 423/1089 (38%), Gaps = 92/1089 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C + P I W G + + NI + L+I N ++ G Y+ VA
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGG------RTLQILNAQEDNAGRYSCVA 2648
Query: 713 VNREGEASLPIVLK------IKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
N GE +K I G+ P + P K + ++ ++ L + P ++
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPG-LSP-KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 767 TWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+W K+ +P+K+ + H++ I K ++ D G YT A N G E + ++ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQI-KEAQISDTGRYTCVASNIAGEDELDFDVNIQVP 2765
Query: 826 T--EENAEPPLFINRFQEITVKE---KGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
++ E ++ + K+ I L P P++TWY++ ++ S+ +
Sbjct: 2766 PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVL 2825
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS--HGARVTIDVEKVTFVKHLQKSY 938
G +++ V+ D+G Y CVA N AG+ S + RV + L +
Sbjct: 2826 ILPGGRVLQIPRAKVE---DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEV 2882
Query: 939 ETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
K+ ++EC +S + + + W + + + DH + + GR D+G
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGR 2940
Query: 997 IKCIVKDQETSTMLVVKETI---PEFIR-KLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
C+ ++ S + P I K ++ V + L E++ D+ W +
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPE 1108
+ + IK N G R L I V D GEY+CI +++ ++ V +PP
Sbjct: 3001 NEQPIKLNTNTL-IVPGG--RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 1109 IITR----LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
I L V +G + E E ++ W+K+G I S H+++ DG Q L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QML 3115
Query: 1164 KIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I ++ D G+Y C N K + PSI R E I+ + LT
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTC 3173
Query: 1219 E---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ IP T + W K IE+++ + L I + D YTC+ + +
Sbjct: 3174 DATGIPPPT--IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Query: 1276 TT-KLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
K ++ PP + E + + G +V L+ + P P +W+ + K I +
Sbjct: 3232 KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN---- 1388
+ + + ++L I +D G Y N G D N+ + P+ G +
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
++ + +SINI E TG W+ + I+ L
Sbjct: 3352 LMTLVDTSINI---ECRATGTPP-----------PQINWLKNGLPLPLSSHIRLLAAGQV 3397
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTC 1503
R V++V + + K +Q P ++ + + IT + C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 1504 IFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVET 1561
I G P P + W RDG+ L A T Y CIA N+ GEV
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3517
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
++ + + P I S E + V + +T + GIP P++ W K+G L + +
Sbjct: 3518 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--V 3575
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREIS 1679
T V+RI + + +YT AS+ AG E ++V+ P + + P + +
Sbjct: 3576 QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR 3635
Query: 1680 RESVTIEWK 1688
VT+E K
Sbjct: 3636 NRQVTLECK 3644
Score = 184 bits (449), Expect = 2e-45
Identities = 262/1206 (21%), Positives = 456/1206 (37%), Gaps = 135/1206 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G+ + C+ G P P + W ++ + ++ S + I E DA +
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE--KSDAALY 2267
Query: 582 TCVAKNAAGFASS--TTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
+CVA N AG A ++ + +++ GS T ++ +GIPP
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPP----- 2321
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P ++ +G ++ KG EI+ DE +L++ N
Sbjct: 2322 PTVTWMKDGHPLIKA---------------KGVEIL-DEG-------------HILQLKN 2352
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS---MIVRQGESVILSA 756
+ G Y VAVN G L + PP +I +S + V + SV L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHA----PPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ G P P+ITW K+ PV + + L ++D G YT N+ G
Sbjct: 2409 EASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK 2468
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
++V P E N +++ VKEK ++ L VT NPVP ITW+++ + +
Sbjct: 2469 IFGLSVLVPPHIVGE-----NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQED 2523
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E G ++ ITNV +G Y C+AS+ AG S + + V + +
Sbjct: 2524 EAHHIISGGRFLQ--ITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPT--IAGVGS 2578
Query: 937 SYETEEGKTVILECQTS--------HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
E+ TVIL TS + W+ + + + I+ GR
Sbjct: 2579 DGNPED-VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRK-------LQDFEVKEK--DVAILE 1037
+ G C+ ++ E VK IP I K L EVK K + LE
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1038 VEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
E + +A + W +DG+ +K + + GH L I+ + D G Y+C+ + +
Sbjct: 2696 CEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2752
Query: 1097 TAEVTV---VELPPEI--ITRLQNQKVNKGNKATFEIELTKGDAL-----------VRWF 1140
E+ +++PP + + N N ++ + +L + W+
Sbjct: 2753 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI 1196
KDG + S+ + + G+ L+I ++DAG Y+C E G + V P I
Sbjct: 2813 KDGHPLTSSDKVLILPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Query: 1197 --NFTLRLPEFILVPANTDAYL-TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
LPE + V N A + + +W K + + + +S+ R L
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSN--GRIL 2928
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE-YRIKRGSDVTLLVDY 1311
I D Y CV + + K + V PP ++ + E + + ++L +
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
FP P+ W+ N + IK +T I +L I + + +D G Y N G +
Sbjct: 2989 SGFPPPDLSWLKNEQPIK--LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWIS 1429
+ ++T+ PS I + DS S+++ N T + E + W
Sbjct: 3047 KFSLTVYVPPS------IKDHDSESLSVV-----NVREGTSVSLECESNAVPPPVITWYK 3095
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEK 1486
+ T ++ L + V++ + K + P++E
Sbjct: 3096 NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEG 3155
Query: 1487 PLKNITTEP-NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXX 1541
P + + E + + LTC G+P P + W ++ K+++ + +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ 3215
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y CIA N G+ + + IQ P + + +G+ + GIP
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W K+G + + + I S + I S + KYT A+N AG L
Sbjct: 3276 PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 1662 VYDKPS 1667
VY P+
Sbjct: 3336 VYVTPT 3341
Score = 180 bits (439), Expect = 4e-44
Identities = 241/1193 (20%), Positives = 429/1193 (35%), Gaps = 91/1193 (7%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+T+ EC+ P ++W++ +K + N TL I+E D G +TCV
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---NGHTLQIKEAQISDTGRYTCV 2746
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG ++ ++ P S ++L+ + +A+
Sbjct: 2747 ASNIAGEDELDFDVNIQVPPS-------------FQKLWEIGNMLDT-----GRNGEAKD 2788
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + I L C A P P + W G + + + + VL+I K
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG------RVLQIPRAKVED 2842
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G YT VAVN GE SL +++ + + + V +S ++ G+P P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAP 2902
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+W K+ +P+ I + ++ D G Y AEN+ G A+ + V
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV 2962
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P P + + + +TV I L V+ P P ++W +N + I +
Sbjct: 2963 P------PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG 3016
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET---E 941
G ++++ V D G+Y C+A N AG+S +T+ V + H +S
Sbjct: 3017 GRTLQIIRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPP-SIKDHDSESLSVVNVR 3072
Query: 942 EGKTVILECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
EG +V LEC+++ WY N + I+ H EI+ +G+ V +
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 1000 IV---KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
I +D + + V E + E V + + W ++ + I
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRL 1113
+ + + KL I + D G Y+CI + A+ +++PP +
Sbjct: 3193 E-NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 3251
Query: 1114 QNQKVNKGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
V+ E+ L++W KDG I ++ + L IY
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 1171 DDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D G+Y+C N + + P+I E ++ +T +
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 1226 -DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + + L++ + + I + D YTCV + +
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429
Query: 1285 EFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
F P +D E + +GS ++ P P+ W+ + + + H ++ +
Sbjct: 3430 VFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL--TVSTH 3487
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
L + K E D+G Y N G + +L+ P G EI S +N
Sbjct: 3488 GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVIVN--- 3543
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD- 1460
N T I + ++ W+ +Q L R V +
Sbjct: 3544 ----NPLELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGR 3596
Query: 1461 -----ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
S A + + Y V ++P ++IT N + L C VP P +TW
Sbjct: 3597 YTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 1516 YRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
R+G++L+ Y C+A N G+ ++ + P I
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNI 3715
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRI 1632
+ + + ++ + EG+P P + W K+G L N Y+I + + I
Sbjct: 3716 KGGPQSLVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---ENGFLHI 3770
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ + + +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 3823
Score = 178 bits (434), Expect = 2e-43
Identities = 266/1185 (22%), Positives = 444/1185 (37%), Gaps = 112/1185 (9%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
++ +C V G P P I W + +I F++ N LVI + + G + C+A
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL---NGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 587 NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ-YV 645
N AG DH E V +PPT ++ V
Sbjct: 1809 NTAG---------------DHKKEFEVTVH---------------VPPTIKSSGLSERVV 1838
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ + L+C IP P I WL K ++ V ++ I+S VL+I
Sbjct: 1839 VKYKPVALQCIANGIPNPSITWL-KDDQPVNTAQGNLKIQSSGR----VLQIAKTLLEDA 1893
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGESVILSAQVVGNPR 763
G YT VA N GE I L + EPP + + K + V V L + GNP
Sbjct: 1894 GRYTCVATNAAGETQQHIQLHVH----EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPV 1949
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P ITW K+N+ + + + + I ++ ++ D G+Y A NS G E + V
Sbjct: 1950 PVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVH 2009
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
P + V ++L P PS+TW ++ +S Q
Sbjct: 2010 -------VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL 2062
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
G I L +T+ D+G Y CVA N+AG+ + + V + S +
Sbjct: 2063 SGGRI-LALTSAQIS-DTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA 2120
Query: 944 KTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++ + + W + + I E R D G C +
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLS-ISENR-SVLKIEDAQVQDTGRYTCEATN 2178
Query: 1004 --QETSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEINS-ETADVVWERDGE-II 1056
+T V +P I +L V E ++ L E + +++W++ G ++
Sbjct: 2179 VAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRL 1113
+ G R+L I D YSC+ + + TA+ V + P I
Sbjct: 2239 TDSMGRVRILSGG--RQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSG 2296
Query: 1114 QNQK---VNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
+ V +G + E E+ V W KDG + + +++ +G +LK +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLK--NIH 2354
Query: 1170 LDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G Y C N K + PSI R PE I V LT E
Sbjct: 2355 VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIP 2414
Query: 1225 L-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK-STTKLKVE 1282
L +TW+K + + ++S R L + + T +D +YTCV+ +A K+
Sbjct: 2415 LPSITWFKDGWPVSLSNSVRILSG--GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 1283 VVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V PP IV + ++K VTL + P P W + + ++ + I S
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ--EDEAHHIIS 2530
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSS 1395
L I V+ G Y + GH ++ + P+ G P + + +
Sbjct: 2531 GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
S E + +TI ++ + +++ I + +T I N + +++ R+ A
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-KDGTPLESNRNIRILPGGRT-LQILNAQEDNAGRYSCVA 2648
Query: 1456 VNEV-DISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
NE ++ E Y +I + + P + K + + N + L C +P +
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSP--KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 1514 TWYRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+WY+DG+ LK+ N Y C+A N GE E V IQ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 1572 ----VITISNE-DIKQKHKVGDEWLVTAV-----IEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ I N D + + D + + PPP + WYK+G+ L + + I
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLI 2826
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ V++I K + +YT A N AG S++ ++V P
Sbjct: 2827 LPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Score = 176 bits (429), Expect = 6e-43
Identities = 262/1150 (22%), Positives = 439/1150 (38%), Gaps = 122/1150 (10%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLV 658
+ A +SD G T D+ +PP + + V + L C+
Sbjct: 2070 LTSAQISDTG-RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSD 2128
Query: 659 AIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE 718
AIP P + WL G ++ +S++ SVLKI + + G YT A N G+
Sbjct: 2129 AIPPPTLTWLKDGHPLLKKPGLSISENR------SVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 719 ASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
+ I PP + + L + V +G + L + G P P + W K PV
Sbjct: 2183 TEKNYNVNIWV----PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 777 A-----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE-EPTEENA 830
+ S G I+I + D +Y+ A N G A+ + V PT N+
Sbjct: 2239 TDSMGRVRILSGGRQLQISIAEK---SDAALYSCVASNVAGTAKKEYNLQVYIRPTITNS 2295
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
+ EI V +I L V P P++TW ++ + ++ + +G ++L
Sbjct: 2296 G-----SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQL 2350
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQ-KSYETEEGKTVILE 949
+V D+G Y CVA N AG + +++ H ++ E +V L
Sbjct: 2351 KNIHVS---DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 950 CQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--E 1005
C+ S S W+ + +S + I+ GR D G C+V++ E
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNSVRILSGGR--MLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 1006 TSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKN 1061
+ + +P I L+D +VKEK L E+ + ++ W +DG+ ++ +
Sbjct: 2466 ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDE 2524
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELP----------P 1107
+ G R L I N V G Y+C+ +S + + V P P
Sbjct: 2525 AHHIISGG--RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNP 2582
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
E +T + N + +A + A + WFKDG+ ++ + +I++ G+ L+I +
Sbjct: 2583 EDVTVILNSPTSLVCEA-----YSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 1168 CDLDDAGEYSCEVGNSKCTAILTVE-----EPSIN----FTLRL-PEFILVPANTDAYLT 1217
D+AG YSC N I E P IN + L P+ + + N L
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1218 VE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E IP +L +WYK ++ + + ++ TL I++ D YTCV +
Sbjct: 2696 CEAYAIPSASL--SWYKDGQPLKSDDHVNIAAN--GHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 1275 STTKLKVEV-VEFPP---------KIVDYEREYRIKR---GSDVTLLVDYQAFPQPNDEW 1321
+L +V ++ PP ++D R K + ++L + A P P W
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K I L I + + DAG Y N G ++ +V +L P
Sbjct: 2812 YKDGHPL--TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Query: 1382 SPPGKPNILE------IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK 1435
G + L ++ S++ C ++ E D +++S I +
Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQ 2929
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N + R+ A N A +Y+ + + + +N+T
Sbjct: 2930 ----ILNTQITDIGRYVCVAEN-----TAGSAKKYFNL--NVHVPPSVIGPKSENLTVVV 2978
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
N I LTC G P P ++W ++ + KL T Y CIA
Sbjct: 2979 NNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGN 1611
N GE + + + P I + + V + V+ E +PPP + WYKNG
Sbjct: 3039 NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGR 3098
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS--KP 1669
+ I + ++ IK+ + S + +Y A N AG L VY PS P
Sbjct: 3099 MITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGP 3156
Query: 1670 EGPVIMREIS 1679
E VI+ IS
Sbjct: 3157 EREVIVETIS 3166
Score = 173 bits (422), Expect = 4e-42
Identities = 232/1115 (20%), Positives = 425/1115 (38%), Gaps = 83/1115 (7%)
Query: 594 STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL 653
S L +E G E T ++ + PT + EG + L
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTL 1000
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C+ P+P + W KGE ++ + + +D +Y + + + G Y A
Sbjct: 1001 PCKASGNPKPSVIWSKKGE-LISTSSAKFSAGADGSLY-----VVSPGGEESGEYVCTAT 1054
Query: 714 NREGEASLPIVLKIKT-----GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
N G A + L + G++ +P++ ++ GE V L +V P P ITW
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITW 1113
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
K + + + + + D G+Y A N G + + V P +
Sbjct: 1114 AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNFDGEN 887
P + ++ V ++ I A+ T P+P ITW + ++ E N DG
Sbjct: 1174 QRGP-----KHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHHVSNPDGT- 1225
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE-----E 942
L I D+G Y CVA+N AG +T+ V++ V+ L+ Y T
Sbjct: 1226 --LSIDQATPS-DAGIYTCVATNIAGTDE--TEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 943 GKTVILECQTSHTV--STKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ + C T + KW HN +E++G + I+++G D G C
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG--TLLVIASVTPYDNGEYIC 1338
Query: 1000 IVKDQETST--MLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVV-WERDG 1053
+ ++ +T +K +P I+ ++ + V + L E+ + ++ W +D
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ + + G I KL+ + D G YSC + + T++ V +PP II
Sbjct: 1399 VQVT-ESSTIQTVNNGKILKLF--RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 1111 -TRLQNQ-KVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T N+ V E ++ KG + WFKDG + F + + + Q L +
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLK 1513
Query: 1167 DCDLDDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
+ +D G Y C V N+ LT+ P + I V N+ L E
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 1223 ETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ +TWYK I + + I K + L I + D YTC + + T +
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Query: 1282 EVVEFPPKIVDYEREYRIKR----GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V + P +++ + + +TL P P W+ + +K + +
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-- 1689
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
I++ L I + D G Y + G +++ V +L P+ G
Sbjct: 1690 IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 1398 NICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
N+ + TG+ I ++ + Q ID + + + + I + +++ +R A
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N ++ K + T PT++ L + + L CI G+P P +TW
Sbjct: 1809 NTAG--------DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW 1860
Query: 1516 YRDGKKLKTAKATYENRXX---XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+D + + TA+ + + Y C+A N GE + + + + P
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + + + + V + + G P P + WYK+ L ++T + +I I
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGST--SMTFLNRGQIIDI 1978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + S + Y A N+AG + + +L+V+ PS
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 173 bits (421), Expect = 6e-42
Identities = 252/1208 (20%), Positives = 458/1208 (37%), Gaps = 111/1208 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S C+ YP ITWF+ ++ +++ ++ TL I ++AG ++CV
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PGGRTLQILNAQEDNAGRYSCV 2647
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG E+ V P + ++ P S PK
Sbjct: 2648 ATNEAGEMIKHYEVKVYIPPIINKGDLW--------------------GPGLS--PKEVK 2685
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+ + + LEC AIP ++W G+ + D+++++A L+I +
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH------TLQIKEAQISD 2739
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP--QVIEPLKSMIV--RQGES--------V 752
G YT VA N GE L + I+ PP Q + + +M+ R GE+ +
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNIQV----PPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L + P PT+TW K+ P+ + + + KV+D G YT A N G
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Query: 813 IAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ V P N++ P +E+TV + + + +P P +W ++
Sbjct: 2856 EDSLQYDVRVLVPPIIKGANSDLP------EEVTVLVNKSALIECLSSGSPAPRNSWQKD 2909
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + + +G ++++ T + D G Y CVA N+AG + + + V +
Sbjct: 2910 GQPLLEDDHHKFLSNGRILQILNTQIT---DIGRYVCVAENTAGSAKKYFNLNVHVPP-S 2965
Query: 930 FVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ ++ + L C+ S W N++ I + I+ GR
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 988 XXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR-----KLQDFEVKEKDVAILEVEI 1040
D G CI +Q E+ + +P I+ L V+E LE E
Sbjct: 3026 KVS--DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES 3083
Query: 1041 NSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N+ V+ W ++G +I + E + L+I+ V D G+Y C + + +
Sbjct: 3084 NAVPPPVITWYKNGRMITESTH---VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Query: 1100 VTV---VELPPEIITRLQNQKVNK-GNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQL 1154
V +PP I + V N T + T + W K+ I+ S+ +++
Sbjct: 3141 KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEV 3200
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPA 1210
I KL+I D+G Y+C N + A L+++ P +P + V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL 3260
Query: 1211 NTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ L T + W K I E + TL I D +YTCV
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--PQPNDEWIVNS 1325
+ + + V P + + ++ D ++ ++ +A P P W+ N
Sbjct: 3321 ATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP- 1384
+ H + + + + I + + +D +Y N G + N+ + P+
Sbjct: 3381 LPLPLSSHIR--LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDN 3438
Query: 1385 --GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
G I + SS ++ S + ++ + Q + ++V +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMV-LQLLK 3495
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYY--KVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+T S ++ A NE A E ++++ KV++ I + + I P +E
Sbjct: 3496 AETEDSGKYTCIASNE-----AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP---LE 3547
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
LTCI G+P PK+TW +DG+ L T Y C+A + G+
Sbjct: 3548 LTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGD 3607
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ +V + P I ++E + + + +PPP + W +NG +L+
Sbjct: 3608 DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR 3667
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
I + + ++I ++ YT ASN AG ++ E L V P+ GP + +
Sbjct: 3668 VRILSGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVIL 3725
Query: 1679 SRESVTIE 1686
+S +E
Sbjct: 3726 LNKSTVLE 3733
Score = 165 bits (402), Expect = 1e-39
Identities = 238/1078 (22%), Positives = 414/1078 (38%), Gaps = 81/1078 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 847
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 906
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 962
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 1015 SKKGELISTSSAKFSAGADG---SLYVVSPGGE-ESGEYVCTATNTAGYAKRKVQLTVYV 1070
Query: 926 EKVTF--VKHLQKSYETE----EGKTVILECQTSHTVS--TKWYHNKKEISGMDHREIIQ 977
F + L + E G+ V L C+ W + IS R
Sbjct: 1071 RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL 1130
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVA 1034
D G+ C+ + + VK + P+ R + +V+
Sbjct: 1131 P--SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ V+ W + G + + G L I + D G Y+C+ +
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATN 1245
Query: 1094 ESCTAEV----------TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ T E TV +L P T Q + N+ + + T ++W +G
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KPTIKWLHNG 1304
Query: 1144 SEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
E+ I + DG L I D GEY C E G ++ L V P +
Sbjct: 1305 RELTGREPGISILEDG--TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIK 1362
Query: 1199 TLRLPEFILVPAN--TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIR 1256
+ V N T+ + VE + + WYK ++ TE T+ + + L +
Sbjct: 1363 DKEQVTNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDN--VQVTESSTIQTVNNGKILKLF 1419
Query: 1257 KCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQA 1313
+ T +D Y+C ++ T++ + V PP I+ ++ E + DV L +
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKG 1479
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P P+ W + K + +D + L +K D G Y+ + N G ++
Sbjct: 1480 TPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+TI PS G +I ++ E E G I + + Q I ++
Sbjct: 1539 KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS--QALY 1596
Query: 1433 ITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
I K Q I + + S + + N ++ +E + + V I+ + PL N
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVAN---VAGTAEKSFHVDVYVPPMIEG-NLATPL-NK 1651
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYK 1549
+ L C G P P +TW +DG +K Y
Sbjct: 1652 QVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYI 1711
Query: 1550 CIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
C+A + GE E V + P I +E V + + + G PPP ++W K+
Sbjct: 1712 CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD 1771
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
G ++ + I + V I + + S++ Y A+NTAG E + V+ P+
Sbjct: 1772 GQLIDERDGFKILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 164 bits (399), Expect = 3e-39
Identities = 241/1072 (22%), Positives = 409/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 3301
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M +
Sbjct: 3302 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD- 3357
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 3358 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 3418 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 3473 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 3524
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3584
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 3585 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3699
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 3757
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 3758 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 3813
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3871
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 3932 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 3989
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 3990 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 4040
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 4159 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 4214
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 4215 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4266
Score = 160 bits (389), Expect = 4e-38
Identities = 222/1029 (21%), Positives = 397/1029 (38%), Gaps = 84/1029 (8%)
Query: 680 ISVAIESDMHMYCSV-LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+++ ++ + SV L I V EG Y +AV+ G + EPP VI
Sbjct: 468 VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS----EPPPVI 523
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKV 797
+ ++ V GE +L+ ++ +TW +N++ V+ A P + + LK K
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF 583
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y + G + S +TV+EP + P + Q T + + ++ T
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP-----KNQSFTGGSE--VSIMCSAT 636
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P I W N+ I S DG L I N + D+G Y C+ASNSAG
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG---TLFIKNAAPK-DAGIYGCLASNSAGTDKQ 692
Query: 918 GARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHRE 974
+ + I+ K+ V Q G ++EC+TS KW+ E+
Sbjct: 693 NSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF-- 747
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+I + D G C+ ++ T + + + P FI++ D ++
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807
Query: 1032 DVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
L + + W R D I + + L+I N D+G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 1090 ILRDE--SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDALV--RWFKD 1142
++ +E TV + P I V +G + T L G+ + RW K+
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-----NSKCTAILTVEEPSIN 1197
+ + + +I + DG L I L D GEY+C N+K T+++ P+I
Sbjct: 928 SAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 1198 FTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLII 1255
++ I +P + + V W KK +I + KF+ +D +L +
Sbjct: 985 HGQQILSTIEGIPVTLPCKAS---GNPKPSVIWSKKGELISTSSAKFSAGAD---GSLYV 1038
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER--------EYRIKRGSDVT 1306
++ EY C + K KV++ V P++ +R E + G +VT
Sbjct: 1039 VSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
L + ++ P P W +++I + S S+ I + +D+G+Y N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKITETRTSDSGMYLCVATNIA 1156
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G+ + + + P P L++ + D P N + + V+ + + +T
Sbjct: 1157 GNVTQAVKLNVHVPPKIQRGPKHLKV---QVGQRVDIPCNAQGTPL--PVITWSKGGSTM 1211
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE- 1485
+ ++ ++ + Y +I+ E TE ++E PTVE
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE-TEITLHVQE----PPTVED 1266
Query: 1486 -KPLKNITTE---PNEDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXX 1538
+P N T + N+ IE C G P+P + W +G++L + + E+
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIA 1326
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N+ G E + + PVI + + + +EG
Sbjct: 1327 SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P ++WYK + ++ + I T ++++ + +Y+ +A N AGTS
Sbjct: 1387 TPSPIIMWYK--DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 1659 TLKVYDKPS 1667
+ V P+
Sbjct: 1445 NIDVLVPPT 1453
Score = 151 bits (367), Expect = 2e-35
Identities = 241/1167 (20%), Positives = 421/1167 (36%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 3506
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 3561
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 3562 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 3592
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 3593 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 3647
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 3648 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 3708 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 3760
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 3761 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 3817
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 3878 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 3937
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 3938 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3994
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4050
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 4106
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S +L I D YTC+ + S+T K
Sbjct: 4107 PPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4162
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 4163 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 4218
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 4219 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 4267
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 4268 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4324
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K I ++ P V K + EP + L C G P P + W
Sbjct: 4325 TYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN 4384
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 4445 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 4499
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 4500 QKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 149 bits (362), Expect = 8e-35
Identities = 233/1097 (21%), Positives = 389/1097 (35%), Gaps = 84/1097 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + PK Q GS++ + C P+P IAW IV + SD
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT--SD----- 663
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N G Y +A N G L+ E P+++ ++V G+
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRY----IEAPKLMVVQSELLVALGDIT 719
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G P P + W K + ++ + ++ + D G YT A N G
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NN 870
A + V PP+FI +++++ + L V P P+I W R N
Sbjct: 780 RATGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I S +++ L I N+ + D G Y C A N GK VT+
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ EG+ + L C + +W N + + + +G
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
+ + V T VV +P Q E L + + +
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPS 1011
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
V+W + GE+I K+ G LY+ + + GEY C + + A+ V V
Sbjct: 1012 VIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 1104 ELPPEII---TRLQNQK-----VNKGNKATFEIEL-TKGDALVRWFKDGSEIQ-FSNHIQ 1153
+ P + L K V G + T E+ + ++ W K+ I FS
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHT 1128
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
G +KI + D+G Y C GN L V P R P+ + V
Sbjct: 1129 FLPSG---SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP--KIQRGPKHLKVQ 1183
Query: 1210 ANTDAYLTVEIPDETLDV-TWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L V TW K S ++ D E D TL I + T D YT
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATPSDAGIYT 1240
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIK-----RGSDVTLLVDYQAFPQPNDEW 1321
CV + T + ++ + V+ PP + D E Y + + P+P +W
Sbjct: 1241 CVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW 1300
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ N + + + SI L I V D G Y N G + + N+ + P
Sbjct: 1301 LHNGRELTG-REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Query: 1382 SPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
K + + + + + E E T + I++Y + TE +++ + +
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQVTESSTIQTVNNGK-- 1414
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNED 1498
I L + Y+ ++I+ S+ +Y+ + + + + N ++ N D
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQ--KYFNI--DVLVPPTIIGTNFPNEVSVVLNRD 1470
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCIAFND 1555
+ L C G P P + W++DGK L E Y+C N
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G+ + I P I N + + G+P P + WYK+G + +
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG---- 1671
+ +K + I + S S+ YT +N AGT+ + VY P EG
Sbjct: 1591 SSQ--ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY-VPPMIEGNLAT 1647
Query: 1672 PVIMREISRESVTIEWK 1688
P+ + + S+T+E K
Sbjct: 1648 PLNKQVVIAHSLTLECK 1664
Score = 147 bits (356), Expect = 4e-34
Identities = 238/1118 (21%), Positives = 422/1118 (37%), Gaps = 93/1118 (8%)
Query: 599 IVEAPLSDHGS-EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
I + LSD G E D+ E PP + P V G +L C +
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
++ + ++ W ++ E + +++ L++ +VK G Y + + G
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-----LELKSVKFNDAGEYHCMVSSEGG 598
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA 777
++ + L + +EPP+V K+ G V + G P+P I W N+ +
Sbjct: 599 SSAASVFLTV----QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 778 LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-AETSAVITVEEPTEENAEPPLFI 836
+ + +K KD G+Y A NS G + S + +E P + L +
Sbjct: 655 -SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLV 713
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
+ITV E + + P P + W++ + + PS + + + L+
Sbjct: 714 -ALGDITVME-------CKTSGIPPPQVKWFKGDLELRPSTFLIID---PLLGLLKIQET 762
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSH 954
++D+GDY CVA N AG+++ ++T+DV E G V L C Q
Sbjct: 763 QDLDAGDYTCVAINEAGRAT--GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Query: 955 TVSTKW--YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETST 1008
+ KW N S I + R D G C ++Q ++ T
Sbjct: 821 EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 1009 MLVVKETIPEFIRKLQDF-EVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDF 1065
+ V + I V E L + + + W ++ ++ +N Y
Sbjct: 881 TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML--LQNPYIT 938
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITRLQNQKVNKGN 1122
+ L+I + D GEY+C+ + + T T VV + P I Q +G
Sbjct: 939 VRSD--GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + V W K G I S+ DG L + +++GEY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTA 1053
Query: 1179 --EVGNSKCTAILTV-EEPSI-----NFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTW 1229
G +K LTV P + + P I V A + L E+ +TW
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 1230 YKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
K+ +I + + T + ++ I + D Y CV + V++ V P
Sbjct: 1114 AKETQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLT 1346
PKI + +++ G V + + Q P P W S ++ +H + + +L+
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEH---HVSNPDGTLS 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSSSINICW 1401
I + +DAGIY N G + E+ + + + P+ PP E ++ I +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-RIEF 1286
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
P I ++ +E+ E IS+ T I ++ + + AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILE-DGTLLVIASVTPYDNGEYICVAVNE-- 1343
Query: 1461 ISDASETTEYYKVIKETKIQSPTV---EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
A T Y + K+ P V ++ + N++ N+ L C G P P + WY+
Sbjct: 1344 ---AGTTERKYNL----KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Query: 1518 DGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
D ++ + T N Y C A N G + + + P I
Sbjct: 1397 DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
+N + + + + ++G P P++ W+K+G L + N+ ++ V+ +K
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
+R+ +Y SN AG + ++ L +Y PS G V
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553
Score = 121 bits (291), Expect = 3e-26
Identities = 205/965 (21%), Positives = 343/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 3618 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 3674
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 3675 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 3727
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 3728 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 3787
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 3788 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 3898
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 3899 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 4018 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 4074
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 4075 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 4131
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 4132 S---LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 4185
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 4242
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 4243 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 4302
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P +
Sbjct: 4303 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP-------VF 4351
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ D S W EP G + I+ V+ T +W + I+ L S
Sbjct: 4352 KGDYPS---NWIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS--- 4403
Query: 1451 FRAYAVNEVDISD-ASETTEYYKVIKET---KIQSPTV--EKPLKNITTEPNEDIELTCI 1504
Y D D T V++ + +QSP + +P++ + + I L C
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK-IILNCQ 4462
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 4523 PVIVQ 4527
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C GYP+P+I W I S ++M D TL I+ P+DAG + C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD----GTLFIKNAAPKDAGIYGC 681
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+A N+AG + L +EAP
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP 702
Score = 51.6 bits (118), Expect = 3e-05
Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V EC+ P P ITW++ +I S ++ D L I++
Sbjct: 3064 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 3120
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 3179
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 3180 PPTIAWLKNHKRIENSD-SLEVRILS 3204
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 773 VAINEAGRATGKITLDVGSP 792
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 489 NEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
++K ++ V PT + ++ V K +P V +C G P P ITW +
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKP--------VALQCIANGIPNPSITWLKDDQ 1865
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +Q V L I + EDAG +TCVA NAAG +L V P S
Sbjct: 1866 PVNTAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 4313
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF + + V+ P
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Score = 47.2 bits (107), Expect = 6e-04
Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 1658
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC+ G P P +TW + +K + + ++ + + +E+ D G + CVA
Sbjct: 1659 LTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT 1715
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q +
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI 1775
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVS 1798
Score = 47.2 bits (107), Expect = 6e-04
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G C+V+G P P I W R+ I+ S + + +L I EDAG +
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVNEDAGDY 4417
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA N AG + L +++P
Sbjct: 4418 TCVATNEAGVVERSMSLTLQSP 4439
Score = 45.6 bits (103), Expect = 0.002
Identities = 38/185 (20%), Positives = 69/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ V +++ PV + +G ++ ++G P
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFK-GDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 4379 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 1662 VYDKP 1666
+ P
Sbjct: 4436 LQSPP 4440
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 4239 CVANNAAGEDTHTVSLTV 4256
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 4044
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 4454 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 4509
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 4510 VARNLMGSVLVRVPVIVQ 4527
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 3910 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 3962
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 3963 GRYTCVARNAAGSAHRHVTLHVHEP 3987
>AL135797-1|CAI17871.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-77J13 on chromosome 1. ).
Length = 5635
Score = 235 bits (574), Expect = 2e-60
Identities = 291/1201 (24%), Positives = 482/1201 (40%), Gaps = 129/1201 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ EC+V+G P P +TW + + ++ ++ D+ ++ L ++ + D G + C
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHI--LQLKNIHVSDTGRYVC 2363
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA N AG +L V AP S G+ + P S
Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRS--------------------PENIS------ 2397
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V E + + L C IP P I W FK V N SV I S M L++
Sbjct: 2398 -VVEKNSVSLTCEASGIPLPSITW-FKDGWPVSLSN-SVRILSGGRM----LRLMQTTME 2450
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGN 761
G YT V N GE L + PP ++ L+ + V++ +SV L+ +V GN
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLV----PPHIVGENTLEDVKVKEKQSVTLTCEVTGN 2506
Query: 762 PRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P ITW K+ +P+ +A S G IT + +V G YT A + G S
Sbjct: 2507 PVPEITWHKDGQPLQEDEAHHIISGGRFLQITNV---QVPHTGRYTCLASSPAGHKSRSF 2563
Query: 819 VITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+ V PT +++TV LV P +ITW+++ + +
Sbjct: 2564 SLNVFVSPTIAGVGSD---GNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2620
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL--- 934
I G ++++ D ++G Y CVA+N AG+ V + + + L
Sbjct: 2621 NIRILPGGRTLQILNAQED---NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGP 2677
Query: 935 ---QKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
K + + T+ LEC+ + S WY + + + DH I G
Sbjct: 2678 GLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2735
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIRKLQDF--------EVKEKDVAI---- 1035
D G C+ + E V +P +KL + + KDV I
Sbjct: 2736 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 1036 -LEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L E N + + W +DG + +K G R L I V D G Y+C+ +
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPL-TSSDKVLILPGG--RVLQIPRAKVEDAGRYTCVAVN 2852
Query: 1094 ES--CTAEVTVVELPPEII----TRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSE 1145
E+ + + V L P II + L + NK+ L+ G R W KDG
Sbjct: 2853 EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2912
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
+ +H + +G+ L+I + + D G Y C G++K L V P +
Sbjct: 2913 LLEDDHHKFLSNGR--ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970
Query: 1202 LPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E + V N LT E+ D++W K + I+ ++ RTL I +
Sbjct: 2971 -SENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG--GRTLQIIRAKV 3027
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE----YRIKRGSDVTLLVDYQAFP 1315
D EYTC+ ++ +K K + V PP I D++ E ++ G+ V+L + A P
Sbjct: 3028 SDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W N ++I + H + D + L IKK E +D G Y R N G D ++
Sbjct: 3088 PPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145
Query: 1376 TILDKPS--PPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+ PS P + I+E S+ + + D TG I ++ ++ I+ ++ + V+
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDA---TGIPPPTIAWLKNHKRIENSDSLEVRI 3202
Query: 1433 IT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
++ ++ I + + S + A N + +YY + + E P ++
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNM-----EGKAQKYYFLSIQVPPSVAGAEIP-SDV 3256
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXXXXXXXX 1547
+ E++EL C G+P P + W +DGK + + + N
Sbjct: 3257 SVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3316
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIW 1606
Y C+A N GE + + + P I + ++ ++ + D + + G PPP++ W
Sbjct: 3317 YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW 3376
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
KNG L + + VIRI + S + YT ASN AG + L+V+ P
Sbjct: 3377 LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPP 3434
Query: 1667 S 1667
+
Sbjct: 3435 N 3435
Score = 215 bits (525), Expect = 1e-54
Identities = 273/1202 (22%), Positives = 469/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 1027
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 1082
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 1083 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 1125
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA N G + + L + PP++
Sbjct: 1126 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV----PPKIQR 1175
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 800 EGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+E PT E+ EPP + FQE ++ A+ T
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 1293
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + + LVI +V + D+G+Y CVA N AG +
Sbjct: 1294 -PKPTIKWLHNGRELTGREPGISILEDGTL-LVIASV-TPYDNGEYICVAVNEAGTTERK 1350
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 1351 YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTM-----LVVKETIPEFIRKLQDFEVKE 1030
G+ D G C + TS ++V TI + V
Sbjct: 1411 NNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN 1468
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ + D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 1469 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 1525
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 1586 QPIMSSSQ-ALYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 1638
Query: 1204 EFI----LVPANTDAY----LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + + + KK
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK-- 1696
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLV 1309
L I E D+ +Y CV ++K EV V PP I D + + + + L
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + ++I + K ++ + + +V NT G+Y+ N G
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 1814
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 1815 KKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQ--- 1871
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 1872 -GNL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 1926
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR-XXXXXXXXXXXXX 1545
N T + ++L C G P P +TWY+D + L + T+ NR
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDA 1986
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLT 2044
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 2045 WLKDGSPVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 1666 PS 1667
P+
Sbjct: 2104 PN 2105
Score = 209 bits (511), Expect = 7e-53
Identities = 270/1179 (22%), Positives = 456/1179 (38%), Gaps = 93/1179 (7%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 1233
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 1234 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTVE------------DLEPPYNTT 1274
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F ++ Q ++ C P+P I WL G E+ E ++I D ++L
Sbjct: 1275 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREP-GISILEDG----TLL 1323
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVI 753
I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVTNVSVLLNQLTN 1379
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439
Query: 814 AETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
++ I V P P + F E++V + L +V P P I W+++ +
Sbjct: 1440 SQKYFNIDVLVP------PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 1494 LFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Query: 933 HLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ + LEC+T + WY + + I I +G+
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611
Query: 991 XXDVGVIKCIVKDQETST--MLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-- 1046
D C V + + V +P I + ++ V + + + A
Sbjct: 1612 --DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNP 1669
Query: 1047 ---VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
+ W +DG +K N E G +KL I + D G+Y C+ + E+
Sbjct: 1670 SPILTWLKDGVPVKANDN-IRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYE 1726
Query: 1103 --VELPPEIITRLQNQK--VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
V +PP I + V N + +T + W KDG I + ++ ++
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLN 1786
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVPANTD 1213
G+K L I + + G Y C N+ K +TV P + L E ++V
Sbjct: 1787 GRK--LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
A + +TW K + +T + L R L I K +D YTCV +A
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903
Query: 1274 KSTTKLKVEV-VEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
T+ +++ V PP + D + + + V L P P W +++++
Sbjct: 1904 AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSG 1963
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N++
Sbjct: 1964 S--TSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMV 2021
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ ++ E ++ + + + V + + ++ + + + + R
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQISDTGR 2080
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 2081 YTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Query: 1511 PKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
P +TW +DG L K + ENR Y C A N G+ E + V I
Sbjct: 2133 PTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW 2192
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I S+E + G+ + GIPPP +IW K G+ + D +
Sbjct: 2193 VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR 2252
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++I ++S ++ Y+ ASN AGT+ E L+VY +P+
Sbjct: 2253 QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPT 2291
Score = 200 bits (488), Expect = 4e-50
Identities = 249/1088 (22%), Positives = 430/1088 (39%), Gaps = 92/1088 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+ S V + + LEC IP P + WL G + N +
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+L +T+ + G YT VAVN GE I L++ PP ++ +++ V ++
Sbjct: 2067 --ILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV----PPNIMGEEQNVSVLISQA 2120
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
V L Q P PT+TW K+ P+ P S + S+ ++ +V+D G YT +A N
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YRNN 870
G E + + + P L ++TV E I L+ + P P++ W + +
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIWKKKGS 2235
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKV 928
+++ S + G +L I ++ + D+ Y CVASN AG K + +V I
Sbjct: 2236 PVLTDSMGRVRILSGGR-QLQI-SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTIT 2293
Query: 929 TFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
H + T GK++ LEC+ + W + + EI+ EG
Sbjct: 2294 NSGSHPTEIIVT-RGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQL 2350
Query: 987 XXXXXXDVGVIKCI------VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + D++ + +I R ++ V EK+ L E
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 1041 NS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ESC 1096
+ + W +DG + N G R L + T++ D G+Y+C++R+ E
Sbjct: 2411 SGIPLPSITWFKDGWPVS-LSNSVRILSGG--RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467
Query: 1097 TAEVTVVELPPEII--TRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQ 1153
V +PP I+ L++ KV + T E+T + W KDG +Q
Sbjct: 2468 KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHH 2527
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSIN--FTLRLPEFI 1206
+ G+ L+I + + G Y+C + S+ ++ P+I + PE +
Sbjct: 2528 IISGGR--FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV 2585
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V N+ L E +TW+K + +E ++ RTL I ED+
Sbjct: 2586 TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG--GRTLQILNAQEDNAGR 2643
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVD---------YEREYRIKRGSDVTLLVDYQAFPQ 1316
Y+CV + EV + P I++ +E +IK + +TL + A P
Sbjct: 2644 YSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPS 2703
Query: 1317 PNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+ W + + +K H +I + +L IK+ + +D G Y N G +++ +V
Sbjct: 2704 ASLSWYKDGQPLKSDDHV--NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVN 2761
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENT--GNSTIIYYVVEYQEIDTTEWISVKN-I 1433
I PP + EI + E ++ N +Y T W + +
Sbjct: 2762 I---QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 1434 TKTQ----------TSIQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQSP 1482
T + I K + R+ AVNE ++ +Y +V+ I+
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA----GEDSLQYDVRVLVPPIIKGA 2874
Query: 1483 TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXX 1540
+ P + +T N+ + C+ G P P+ +W +DG+ L N
Sbjct: 2875 NSDLP-EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQKP-VITISNEDIKQKHKVGDEWLVTAVIEGI 1599
Y C+A N G + + + P VI +E++ V + +T + G
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV--VVNNFISLTCEVSGF 2991
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
PPP++ W KN ++ + I +T ++I K S +YT A N AG S + +
Sbjct: 2992 PPPDLSWLKNEQPIKLNTNTLIVPGGRT--LQIIRAKVSDGGEYTCIAINQAGESKKKFS 3049
Query: 1660 LKVYDKPS 1667
L VY PS
Sbjct: 3050 LTVYVPPS 3057
Score = 197 bits (481), Expect = 3e-49
Identities = 269/1219 (22%), Positives = 480/1219 (39%), Gaps = 120/1219 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S ++ EC+ G P P ITW++ I S +Y D + +V D+ T+TC
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQ-ALYIDKGQYLHIPRAQV--SDSATYTCH 1619
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
N AG A + + V P ++EG T P +
Sbjct: 1620 VANVAGTAEKSFHVDVYVP-----------------------PMIEGNLAT----PLNKQ 1652
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + LEC+ P P + WL G + ++NI + L+I + ++
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK------LEIMSAQEID 1706
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGNP 762
G Y VA + GE + K + PP + + IV + L V G+P
Sbjct: 1707 RGQYICVATSVAGEKEI----KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 763 RPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
PTI W K+ + + ++ +V + G+Y A N+ G + +TV
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE-TITQ 881
P P + + E V + + L P PSITW ++++ ++ ++ +
Sbjct: 1823 HVP------PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-ET 940
G +++ T ++ D+G Y CVA+N+AG++ + + V + ++ K ET
Sbjct: 1877 QSSGRVLQIAKTLLE---DAGRYTCVATNAAGETQQ--HIQLHVHEPPSLEDAGKMLNET 1931
Query: 941 E-EGKTVILECQTS-HTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
V LEC+ + + V WY + + +SG + G+ D G+
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS--DAGIY 1989
Query: 998 KCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDG 1053
KC+ + +T L + P V + LE E A + W +DG
Sbjct: 1990 KCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ N G I L + + + D G Y+C+ + + + + V +PP I+
Sbjct: 2050 SPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107
Query: 1111 TRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
QN V L + DA+ + W KDG + L+I + LKI
Sbjct: 2108 GEEQNVSVLISQAVEL---LCQSDAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKIE 2162
Query: 1167 DCDLDDAGEYSCEVGN--SKCTAILTVE---EPSINFTLRLPEFILVPANTDAYLTVEIP 1221
D + D G Y+CE N K V P+I + L + ++ N + L
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSG 2222
Query: 1222 DETLDVTWYKKKS-VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
++ W KK S V+ D+ + ++S R L I + D Y+CV + T K
Sbjct: 2223 IPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 1280 KVEV-VEFPPKIVD---YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ + V P I + + E + RG ++L + Q P P W+ + + K K +
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE 2340
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK----PNILE 1391
I + L +K + +D G Y N G D + ++++ PS G NI
Sbjct: 2341 --ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISV 2398
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRF 1451
++ +S+++ E +I ++ + +S+ N + + + L+ +
Sbjct: 2399 VEKNSVSLTC-EASGIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTME 2450
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVP 1509
A V + A E K+ + + P + E L+++ + + + LTC G P
Sbjct: 2451 DAGQYTCVVRNAAGEER---KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP 2507
Query: 1510 QPKVTWYRDGKKLKTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
P++TW++DG+ L+ +A + Y C+A + G S + +
Sbjct: 2508 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Query: 1568 QQKPVIT-ISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTK 1624
P I + ++ + V + V E PP + W+K+G LE+++ I
Sbjct: 2568 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2627
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+T ++I + ++ +Y+ A+N AG +KVY P +G + +S + V
Sbjct: 2628 GRT--LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVK 2685
Query: 1685 IEWKPPLDDGGLELTKYAI 1703
I+ L LE YAI
Sbjct: 2686 IKVNNTLT---LECEAYAI 2701
Score = 196 bits (477), Expect = 9e-49
Identities = 270/1212 (22%), Positives = 474/1212 (39%), Gaps = 118/1212 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 890
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 891 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 944
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 945 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 993
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P ++ G Y
Sbjct: 994 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYV 1050
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P + L ++ EI+V + L V P P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 1167
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXX 983
V ++ K + + G+ V + C T +K + + E
Sbjct: 1168 HVPPK--IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225
Query: 984 XXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILE 1037
D G+ C+ + ET L V+E P + L+ ++ VA
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQR 1283
Query: 1038 VEI-----NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
+E + + W +G + ++ + G + L I + + +D GEY C+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAV 1341
Query: 1093 DESCTAEVTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSE 1145
+E+ T E V +PP I + Q V N+ E+E T ++ W+KD +
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQ 1400
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLR 1201
+ S+ IQ +GK LK++ +DAG YSC+ G S+ + V P
Sbjct: 1401 VTESSTIQTVNNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 1202 LPEFILVPANTDAYLTVEIPDETL-DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P + V N D L ++ D+ W+K K + L+ + + L ++
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD--RGQVLHLKNAR 1516
Query: 1260 EDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFP 1315
+D+ Y C + +A K +K+ + PP I + + + S + L + + P
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKL-TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLP 1575
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W + + I ID K L I + + +D+ Y + N G A+ +V
Sbjct: 1576 MPAITWYKDGQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVK 1431
+ P G N+ + + I E + GN S I+ ++ + + +
Sbjct: 1634 DVYVPPMIEG--NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAND----- 1686
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLK 1489
NI + + + L+ S+ V S A E Y+V + P +E
Sbjct: 1687 NI-RIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETS 1742
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXX 1547
N +EL C G P P + W +DG+ + + N
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGL 1802
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C+A N G+ + V + P I S +E + K+K + + GIP P +
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSIT 1859
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+ + N + N+ + V++I + + +YT A+N AG + + L V++
Sbjct: 1860 WLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Query: 1666 PSKPEGPVIMRE 1677
PS + ++ E
Sbjct: 1919 PSLEDAGKMLNE 1930
Score = 193 bits (470), Expect = 7e-48
Identities = 242/1089 (22%), Positives = 423/1089 (38%), Gaps = 92/1089 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C + P I W G + + NI + L+I N ++ G Y+ VA
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGG------RTLQILNAQEDNAGRYSCVA 2648
Query: 713 VNREGEASLPIVLK------IKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
N GE +K I G+ P + P K + ++ ++ L + P ++
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPG-LSP-KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 767 TWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+W K+ +P+K+ + H++ I K ++ D G YT A N G E + ++ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQI-KEAQISDTGRYTCVASNIAGEDELDFDVNIQVP 2765
Query: 826 T--EENAEPPLFINRFQEITVKE---KGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
++ E ++ + K+ I L P P++TWY++ ++ S+ +
Sbjct: 2766 PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVL 2825
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS--HGARVTIDVEKVTFVKHLQKSY 938
G +++ V+ D+G Y CVA N AG+ S + RV + L +
Sbjct: 2826 ILPGGRVLQIPRAKVE---DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEV 2882
Query: 939 ETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
K+ ++EC +S + + + W + + + DH + + GR D+G
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGR 2940
Query: 997 IKCIVKDQETSTMLVVKETI---PEFIR-KLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
C+ ++ S + P I K ++ V + L E++ D+ W +
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPE 1108
+ + IK N G R L I V D GEY+CI +++ ++ V +PP
Sbjct: 3001 NEQPIKLNTNTL-IVPGG--RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 1109 IITR----LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
I L V +G + E E ++ W+K+G I S H+++ DG Q L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QML 3115
Query: 1164 KIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I ++ D G+Y C N K + PSI R E I+ + LT
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTC 3173
Query: 1219 E---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ IP T + W K IE+++ + L I + D YTC+ + +
Sbjct: 3174 DATGIPPPT--IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Query: 1276 TT-KLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
K ++ PP + E + + G +V L+ + P P +W+ + K I +
Sbjct: 3232 KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN---- 1388
+ + + ++L I +D G Y N G D N+ + P+ G +
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
++ + +SINI E TG W+ + I+ L
Sbjct: 3352 LMTLVDTSINI---ECRATGTPP-----------PQINWLKNGLPLPLSSHIRLLAAGQV 3397
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTC 1503
R V++V + + K +Q P ++ + + IT + C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 1504 IFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVET 1561
I G P P + W RDG+ L A T Y CIA N+ GEV
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3517
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
++ + + P I S E + V + +T + GIP P++ W K+G L + +
Sbjct: 3518 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--V 3575
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREIS 1679
T V+RI + + +YT AS+ AG E ++V+ P + + P + +
Sbjct: 3576 QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR 3635
Query: 1680 RESVTIEWK 1688
VT+E K
Sbjct: 3636 NRQVTLECK 3644
Score = 184 bits (449), Expect = 2e-45
Identities = 262/1206 (21%), Positives = 456/1206 (37%), Gaps = 135/1206 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G+ + C+ G P P + W ++ + ++ S + I E DA +
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE--KSDAALY 2267
Query: 582 TCVAKNAAGFASS--TTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
+CVA N AG A ++ + +++ GS T ++ +GIPP
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPP----- 2321
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P ++ +G ++ KG EI+ DE +L++ N
Sbjct: 2322 PTVTWMKDGHPLIKA---------------KGVEIL-DEG-------------HILQLKN 2352
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS---MIVRQGESVILSA 756
+ G Y VAVN G L + PP +I +S + V + SV L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHA----PPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ G P P+ITW K+ PV + + L ++D G YT N+ G
Sbjct: 2409 EASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK 2468
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
++V P E N +++ VKEK ++ L VT NPVP ITW+++ + +
Sbjct: 2469 IFGLSVLVPPHIVGE-----NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQED 2523
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E G ++ ITNV +G Y C+AS+ AG S + + V + +
Sbjct: 2524 EAHHIISGGRFLQ--ITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPT--IAGVGS 2578
Query: 937 SYETEEGKTVILECQTS--------HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
E+ TVIL TS + W+ + + + I+ GR
Sbjct: 2579 DGNPED-VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRK-------LQDFEVKEK--DVAILE 1037
+ G C+ ++ E VK IP I K L EVK K + LE
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1038 VEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
E + +A + W +DG+ +K + + GH L I+ + D G Y+C+ + +
Sbjct: 2696 CEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2752
Query: 1097 TAEVTV---VELPPEI--ITRLQNQKVNKGNKATFEIELTKGDAL-----------VRWF 1140
E+ +++PP + + N N ++ + +L + W+
Sbjct: 2753 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI 1196
KDG + S+ + + G+ L+I ++DAG Y+C E G + V P I
Sbjct: 2813 KDGHPLTSSDKVLILPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Query: 1197 --NFTLRLPEFILVPANTDAYL-TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
LPE + V N A + + +W K + + + +S+ R L
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSN--GRIL 2928
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE-YRIKRGSDVTLLVDY 1311
I D Y CV + + K + V PP ++ + E + + ++L +
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
FP P+ W+ N + IK +T I +L I + + +D G Y N G +
Sbjct: 2989 SGFPPPDLSWLKNEQPIK--LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWIS 1429
+ ++T+ PS I + DS S+++ N T + E + W
Sbjct: 3047 KFSLTVYVPPS------IKDHDSESLSVV-----NVREGTSVSLECESNAVPPPVITWYK 3095
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEK 1486
+ T ++ L + V++ + K + P++E
Sbjct: 3096 NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEG 3155
Query: 1487 PLKNITTEP-NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXX 1541
P + + E + + LTC G+P P + W ++ K+++ + +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ 3215
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y CIA N G+ + + IQ P + + +G+ + GIP
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W K+G + + + I S + I S + KYT A+N AG L
Sbjct: 3276 PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 1662 VYDKPS 1667
VY P+
Sbjct: 3336 VYVTPT 3341
Score = 180 bits (439), Expect = 4e-44
Identities = 241/1193 (20%), Positives = 429/1193 (35%), Gaps = 91/1193 (7%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+T+ EC+ P ++W++ +K + N TL I+E D G +TCV
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---NGHTLQIKEAQISDTGRYTCV 2746
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG ++ ++ P S ++L+ + +A+
Sbjct: 2747 ASNIAGEDELDFDVNIQVPPS-------------FQKLWEIGNMLDT-----GRNGEAKD 2788
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + I L C A P P + W G + + + + VL+I K
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG------RVLQIPRAKVED 2842
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G YT VAVN GE SL +++ + + + V +S ++ G+P P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAP 2902
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+W K+ +P+ I + ++ D G Y AEN+ G A+ + V
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV 2962
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P P + + + +TV I L V+ P P ++W +N + I +
Sbjct: 2963 P------PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG 3016
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET---E 941
G ++++ V D G+Y C+A N AG+S +T+ V + H +S
Sbjct: 3017 GRTLQIIRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPP-SIKDHDSESLSVVNVR 3072
Query: 942 EGKTVILECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
EG +V LEC+++ WY N + I+ H EI+ +G+ V +
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 1000 IV---KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
I +D + + V E + E V + + W ++ + I
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRL 1113
+ + + KL I + D G Y+CI + A+ +++PP +
Sbjct: 3193 E-NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 3251
Query: 1114 QNQKVNKGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
V+ E+ L++W KDG I ++ + L IY
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 1171 DDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D G+Y+C N + + P+I E ++ +T +
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 1226 -DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + + L++ + + I + D YTCV + +
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429
Query: 1285 EFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
F P +D E + +GS ++ P P+ W+ + + + H ++ +
Sbjct: 3430 VFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL--TVSTH 3487
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
L + K E D+G Y N G + +L+ P G EI S +N
Sbjct: 3488 GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVIVN--- 3543
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD- 1460
N T I + ++ W+ +Q L R V +
Sbjct: 3544 ----NPLELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGR 3596
Query: 1461 -----ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
S A + + Y V ++P ++IT N + L C VP P +TW
Sbjct: 3597 YTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 1516 YRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
R+G++L+ Y C+A N G+ ++ + P I
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNI 3715
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRI 1632
+ + + ++ + EG+P P + W K+G L N Y+I + + I
Sbjct: 3716 KGGPQSLVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---ENGFLHI 3770
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ + + +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 3823
Score = 178 bits (434), Expect = 2e-43
Identities = 266/1185 (22%), Positives = 444/1185 (37%), Gaps = 112/1185 (9%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
++ +C V G P P I W + +I F++ N LVI + + G + C+A
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL---NGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 587 NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ-YV 645
N AG DH E V +PPT ++ V
Sbjct: 1809 NTAG---------------DHKKEFEVTVH---------------VPPTIKSSGLSERVV 1838
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ + L+C IP P I WL K ++ V ++ I+S VL+I
Sbjct: 1839 VKYKPVALQCIANGIPNPSITWL-KDDQPVNTAQGNLKIQSSGR----VLQIAKTLLEDA 1893
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGESVILSAQVVGNPR 763
G YT VA N GE I L + EPP + + K + V V L + GNP
Sbjct: 1894 GRYTCVATNAAGETQQHIQLHVH----EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPV 1949
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P ITW K+N+ + + + + I ++ ++ D G+Y A NS G E + V
Sbjct: 1950 PVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVH 2009
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
P + V ++L P PS+TW ++ +S Q
Sbjct: 2010 -------VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL 2062
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
G I L +T+ D+G Y CVA N+AG+ + + V + S +
Sbjct: 2063 SGGRI-LALTSAQIS-DTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA 2120
Query: 944 KTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++ + + W + + I E R D G C +
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLS-ISENR-SVLKIEDAQVQDTGRYTCEATN 2178
Query: 1004 --QETSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEINS-ETADVVWERDGE-II 1056
+T V +P I +L V E ++ L E + +++W++ G ++
Sbjct: 2179 VAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRL 1113
+ G R+L I D YSC+ + + TA+ V + P I
Sbjct: 2239 TDSMGRVRILSGG--RQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSG 2296
Query: 1114 QNQK---VNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
+ V +G + E E+ V W KDG + + +++ +G +LK +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLK--NIH 2354
Query: 1170 LDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G Y C N K + PSI R PE I V LT E
Sbjct: 2355 VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIP 2414
Query: 1225 L-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK-STTKLKVE 1282
L +TW+K + + ++S R L + + T +D +YTCV+ +A K+
Sbjct: 2415 LPSITWFKDGWPVSLSNSVRILSG--GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 1283 VVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V PP IV + ++K VTL + P P W + + ++ + I S
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ--EDEAHHIIS 2530
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSS 1395
L I V+ G Y + GH ++ + P+ G P + + +
Sbjct: 2531 GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
S E + +TI ++ + +++ I + +T I N + +++ R+ A
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-KDGTPLESNRNIRILPGGRT-LQILNAQEDNAGRYSCVA 2648
Query: 1456 VNEV-DISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
NE ++ E Y +I + + P + K + + N + L C +P +
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSP--KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 1514 TWYRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+WY+DG+ LK+ N Y C+A N GE E V IQ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 1572 ----VITISNE-DIKQKHKVGDEWLVTAV-----IEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ I N D + + D + + PPP + WYK+G+ L + + I
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLI 2826
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ V++I K + +YT A N AG S++ ++V P
Sbjct: 2827 LPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Score = 176 bits (429), Expect = 6e-43
Identities = 262/1150 (22%), Positives = 439/1150 (38%), Gaps = 122/1150 (10%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLV 658
+ A +SD G T D+ +PP + + V + L C+
Sbjct: 2070 LTSAQISDTG-RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSD 2128
Query: 659 AIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE 718
AIP P + WL G ++ +S++ SVLKI + + G YT A N G+
Sbjct: 2129 AIPPPTLTWLKDGHPLLKKPGLSISENR------SVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 719 ASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
+ I PP + + L + V +G + L + G P P + W K PV
Sbjct: 2183 TEKNYNVNIWV----PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 777 A-----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE-EPTEENA 830
+ S G I+I + D +Y+ A N G A+ + V PT N+
Sbjct: 2239 TDSMGRVRILSGGRQLQISIAEK---SDAALYSCVASNVAGTAKKEYNLQVYIRPTITNS 2295
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
+ EI V +I L V P P++TW ++ + ++ + +G ++L
Sbjct: 2296 G-----SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQL 2350
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQ-KSYETEEGKTVILE 949
+V D+G Y CVA N AG + +++ H ++ E +V L
Sbjct: 2351 KNIHVS---DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 950 CQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--E 1005
C+ S S W+ + +S + I+ GR D G C+V++ E
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNSVRILSGGR--MLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 1006 TSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKN 1061
+ + +P I L+D +VKEK L E+ + ++ W +DG+ ++ +
Sbjct: 2466 ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDE 2524
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELP----------P 1107
+ G R L I N V G Y+C+ +S + + V P P
Sbjct: 2525 AHHIISGG--RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNP 2582
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
E +T + N + +A + A + WFKDG+ ++ + +I++ G+ L+I +
Sbjct: 2583 EDVTVILNSPTSLVCEA-----YSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 1168 CDLDDAGEYSCEVGNSKCTAILTVE-----EPSIN----FTLRL-PEFILVPANTDAYLT 1217
D+AG YSC N I E P IN + L P+ + + N L
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1218 VE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E IP +L +WYK ++ + + ++ TL I++ D YTCV +
Sbjct: 2696 CEAYAIPSASL--SWYKDGQPLKSDDHVNIAAN--GHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 1275 STTKLKVEV-VEFPP---------KIVDYEREYRIKR---GSDVTLLVDYQAFPQPNDEW 1321
+L +V ++ PP ++D R K + ++L + A P P W
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K I L I + + DAG Y N G ++ +V +L P
Sbjct: 2812 YKDGHPL--TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Query: 1382 SPPGKPNILE------IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK 1435
G + L ++ S++ C ++ E D +++S I +
Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQ 2929
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N + R+ A N A +Y+ + + + +N+T
Sbjct: 2930 ----ILNTQITDIGRYVCVAEN-----TAGSAKKYFNL--NVHVPPSVIGPKSENLTVVV 2978
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
N I LTC G P P ++W ++ + KL T Y CIA
Sbjct: 2979 NNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGN 1611
N GE + + + P I + + V + V+ E +PPP + WYKNG
Sbjct: 3039 NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGR 3098
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS--KP 1669
+ I + ++ IK+ + S + +Y A N AG L VY PS P
Sbjct: 3099 MITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGP 3156
Query: 1670 EGPVIMREIS 1679
E VI+ IS
Sbjct: 3157 EREVIVETIS 3166
Score = 173 bits (422), Expect = 4e-42
Identities = 232/1115 (20%), Positives = 425/1115 (38%), Gaps = 83/1115 (7%)
Query: 594 STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL 653
S L +E G E T ++ + PT + EG + L
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTL 1000
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C+ P+P + W KGE ++ + + +D +Y + + + G Y A
Sbjct: 1001 PCKASGNPKPSVIWSKKGE-LISTSSAKFSAGADGSLY-----VVSPGGEESGEYVCTAT 1054
Query: 714 NREGEASLPIVLKIKT-----GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
N G A + L + G++ +P++ ++ GE V L +V P P ITW
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITW 1113
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
K + + + + + D G+Y A N G + + V P +
Sbjct: 1114 AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNFDGEN 887
P + ++ V ++ I A+ T P+P ITW + ++ E N DG
Sbjct: 1174 QRGP-----KHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHHVSNPDGT- 1225
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE-----E 942
L I D+G Y CVA+N AG +T+ V++ V+ L+ Y T
Sbjct: 1226 --LSIDQATPS-DAGIYTCVATNIAGTDE--TEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 943 GKTVILECQTSHTV--STKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ + C T + KW HN +E++G + I+++G D G C
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG--TLLVIASVTPYDNGEYIC 1338
Query: 1000 IVKDQETST--MLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVV-WERDG 1053
+ ++ +T +K +P I+ ++ + V + L E+ + ++ W +D
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ + + G I KL+ + D G YSC + + T++ V +PP II
Sbjct: 1399 VQVT-ESSTIQTVNNGKILKLF--RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 1111 -TRLQNQ-KVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T N+ V E ++ KG + WFKDG + F + + + Q L +
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLK 1513
Query: 1167 DCDLDDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
+ +D G Y C V N+ LT+ P + I V N+ L E
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 1223 ETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ +TWYK I + + I K + L I + D YTC + + T +
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Query: 1282 EVVEFPPKIVDYEREYRIKR----GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V + P +++ + + +TL P P W+ + +K + +
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-- 1689
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
I++ L I + D G Y + G +++ V +L P+ G
Sbjct: 1690 IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 1398 NICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
N+ + TG+ I ++ + Q ID + + + + I + +++ +R A
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N ++ K + T PT++ L + + L CI G+P P +TW
Sbjct: 1809 NTAG--------DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW 1860
Query: 1516 YRDGKKLKTAKATYENRXX---XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+D + + TA+ + + Y C+A N GE + + + + P
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + + + + V + + G P P + WYK+ L ++T + +I I
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGST--SMTFLNRGQIIDI 1978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + S + Y A N+AG + + +L+V+ PS
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 173 bits (421), Expect = 6e-42
Identities = 252/1208 (20%), Positives = 458/1208 (37%), Gaps = 111/1208 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S C+ YP ITWF+ ++ +++ ++ TL I ++AG ++CV
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PGGRTLQILNAQEDNAGRYSCV 2647
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG E+ V P + ++ P S PK
Sbjct: 2648 ATNEAGEMIKHYEVKVYIPPIINKGDLW--------------------GPGLS--PKEVK 2685
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+ + + LEC AIP ++W G+ + D+++++A L+I +
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH------TLQIKEAQISD 2739
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP--QVIEPLKSMIV--RQGES--------V 752
G YT VA N GE L + I+ PP Q + + +M+ R GE+ +
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNIQV----PPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L + P PT+TW K+ P+ + + + KV+D G YT A N G
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Query: 813 IAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ V P N++ P +E+TV + + + +P P +W ++
Sbjct: 2856 EDSLQYDVRVLVPPIIKGANSDLP------EEVTVLVNKSALIECLSSGSPAPRNSWQKD 2909
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + + +G ++++ T + D G Y CVA N+AG + + + V +
Sbjct: 2910 GQPLLEDDHHKFLSNGRILQILNTQIT---DIGRYVCVAENTAGSAKKYFNLNVHVPP-S 2965
Query: 930 FVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ ++ + L C+ S W N++ I + I+ GR
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 988 XXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR-----KLQDFEVKEKDVAILEVEI 1040
D G CI +Q E+ + +P I+ L V+E LE E
Sbjct: 3026 KVS--DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES 3083
Query: 1041 NSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N+ V+ W ++G +I + E + L+I+ V D G+Y C + + +
Sbjct: 3084 NAVPPPVITWYKNGRMITESTH---VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Query: 1100 VTV---VELPPEIITRLQNQKVNK-GNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQL 1154
V +PP I + V N T + T + W K+ I+ S+ +++
Sbjct: 3141 KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEV 3200
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPA 1210
I KL+I D+G Y+C N + A L+++ P +P + V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL 3260
Query: 1211 NTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ L T + W K I E + TL I D +YTCV
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--PQPNDEWIVNS 1325
+ + + V P + + ++ D ++ ++ +A P P W+ N
Sbjct: 3321 ATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP- 1384
+ H + + + + I + + +D +Y N G + N+ + P+
Sbjct: 3381 LPLPLSSHIR--LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDN 3438
Query: 1385 --GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
G I + SS ++ S + ++ + Q + ++V +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMV-LQLLK 3495
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYY--KVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+T S ++ A NE A E ++++ KV++ I + + I P +E
Sbjct: 3496 AETEDSGKYTCIASNE-----AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP---LE 3547
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
LTCI G+P PK+TW +DG+ L T Y C+A + G+
Sbjct: 3548 LTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGD 3607
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ +V + P I ++E + + + +PPP + W +NG +L+
Sbjct: 3608 DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR 3667
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
I + + ++I ++ YT ASN AG ++ E L V P+ GP + +
Sbjct: 3668 VRILSGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVIL 3725
Query: 1679 SRESVTIE 1686
+S +E
Sbjct: 3726 LNKSTVLE 3733
Score = 165 bits (402), Expect = 1e-39
Identities = 238/1078 (22%), Positives = 414/1078 (38%), Gaps = 81/1078 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 847
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 906
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 962
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 1015 SKKGELISTSSAKFSAGADG---SLYVVSPGGE-ESGEYVCTATNTAGYAKRKVQLTVYV 1070
Query: 926 EKVTF--VKHLQKSYETE----EGKTVILECQTSHTVS--TKWYHNKKEISGMDHREIIQ 977
F + L + E G+ V L C+ W + IS R
Sbjct: 1071 RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL 1130
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVA 1034
D G+ C+ + + VK + P+ R + +V+
Sbjct: 1131 P--SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ V+ W + G + + G L I + D G Y+C+ +
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATN 1245
Query: 1094 ESCTAEV----------TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ T E TV +L P T Q + N+ + + T ++W +G
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KPTIKWLHNG 1304
Query: 1144 SEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
E+ I + DG L I D GEY C E G ++ L V P +
Sbjct: 1305 RELTGREPGISILEDG--TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIK 1362
Query: 1199 TLRLPEFILVPAN--TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIR 1256
+ V N T+ + VE + + WYK ++ TE T+ + + L +
Sbjct: 1363 DKEQVTNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDN--VQVTESSTIQTVNNGKILKLF 1419
Query: 1257 KCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQA 1313
+ T +D Y+C ++ T++ + V PP I+ ++ E + DV L +
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKG 1479
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P P+ W + K + +D + L +K D G Y+ + N G ++
Sbjct: 1480 TPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+TI PS G +I ++ E E G I + + Q I ++
Sbjct: 1539 KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS--QALY 1596
Query: 1433 ITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
I K Q I + + S + + N ++ +E + + V I+ + PL N
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVAN---VAGTAEKSFHVDVYVPPMIEG-NLATPL-NK 1651
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYK 1549
+ L C G P P +TW +DG +K Y
Sbjct: 1652 QVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYI 1711
Query: 1550 CIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
C+A + GE E V + P I +E V + + + G PPP ++W K+
Sbjct: 1712 CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD 1771
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
G ++ + I + V I + + S++ Y A+NTAG E + V+ P+
Sbjct: 1772 GQLIDERDGFKILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 164 bits (399), Expect = 3e-39
Identities = 241/1072 (22%), Positives = 409/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 3301
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M +
Sbjct: 3302 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD- 3357
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 3358 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 3418 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 3473 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 3524
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3584
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 3585 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3699
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 3757
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 3758 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 3813
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3871
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 3932 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 3989
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 3990 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 4040
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 4159 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 4214
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 4215 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4266
Score = 160 bits (389), Expect = 4e-38
Identities = 222/1029 (21%), Positives = 397/1029 (38%), Gaps = 84/1029 (8%)
Query: 680 ISVAIESDMHMYCSV-LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+++ ++ + SV L I V EG Y +AV+ G + EPP VI
Sbjct: 468 VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS----EPPPVI 523
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKV 797
+ ++ V GE +L+ ++ +TW +N++ V+ A P + + LK K
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF 583
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y + G + S +TV+EP + P + Q T + + ++ T
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP-----KNQSFTGGSE--VSIMCSAT 636
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P I W N+ I S DG L I N + D+G Y C+ASNSAG
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG---TLFIKNAAPK-DAGIYGCLASNSAGTDKQ 692
Query: 918 GARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHRE 974
+ + I+ K+ V Q G ++EC+TS KW+ E+
Sbjct: 693 NSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF-- 747
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+I + D G C+ ++ T + + + P FI++ D ++
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807
Query: 1032 DVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
L + + W R D I + + L+I N D+G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 1090 ILRDE--SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDALV--RWFKD 1142
++ +E TV + P I V +G + T L G+ + RW K+
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-----NSKCTAILTVEEPSIN 1197
+ + + +I + DG L I L D GEY+C N+K T+++ P+I
Sbjct: 928 SAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 1198 FTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLII 1255
++ I +P + + V W KK +I + KF+ +D +L +
Sbjct: 985 HGQQILSTIEGIPVTLPCKAS---GNPKPSVIWSKKGELISTSSAKFSAGAD---GSLYV 1038
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER--------EYRIKRGSDVT 1306
++ EY C + K KV++ V P++ +R E + G +VT
Sbjct: 1039 VSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
L + ++ P P W +++I + S S+ I + +D+G+Y N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKITETRTSDSGMYLCVATNIA 1156
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G+ + + + P P L++ + D P N + + V+ + + +T
Sbjct: 1157 GNVTQAVKLNVHVPPKIQRGPKHLKV---QVGQRVDIPCNAQGTPL--PVITWSKGGSTM 1211
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE- 1485
+ ++ ++ + Y +I+ E TE ++E PTVE
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE-TEITLHVQE----PPTVED 1266
Query: 1486 -KPLKNITTE---PNEDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXX 1538
+P N T + N+ IE C G P+P + W +G++L + + E+
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIA 1326
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N+ G E + + PVI + + + +EG
Sbjct: 1327 SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P ++WYK + ++ + I T ++++ + +Y+ +A N AGTS
Sbjct: 1387 TPSPIIMWYK--DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 1659 TLKVYDKPS 1667
+ V P+
Sbjct: 1445 NIDVLVPPT 1453
Score = 151 bits (367), Expect = 2e-35
Identities = 241/1167 (20%), Positives = 421/1167 (36%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 3506
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 3561
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 3562 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 3592
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 3593 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 3647
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 3648 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 3708 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 3760
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 3761 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 3817
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 3878 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 3937
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 3938 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3994
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4050
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 4106
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S +L I D YTC+ + S+T K
Sbjct: 4107 PPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4162
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 4163 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 4218
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 4219 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 4267
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 4268 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4324
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K I ++ P V K + EP + L C G P P + W
Sbjct: 4325 TYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN 4384
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 4445 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 4499
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 4500 QKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 149 bits (362), Expect = 8e-35
Identities = 233/1097 (21%), Positives = 389/1097 (35%), Gaps = 84/1097 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + PK Q GS++ + C P+P IAW IV + SD
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT--SD----- 663
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N G Y +A N G L+ E P+++ ++V G+
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRY----IEAPKLMVVQSELLVALGDIT 719
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G P P + W K + ++ + ++ + D G YT A N G
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NN 870
A + V PP+FI +++++ + L V P P+I W R N
Sbjct: 780 RATGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I S +++ L I N+ + D G Y C A N GK VT+
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ EG+ + L C + +W N + + + +G
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
+ + V T VV +P Q E L + + +
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPS 1011
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
V+W + GE+I K+ G LY+ + + GEY C + + A+ V V
Sbjct: 1012 VIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 1104 ELPPEII---TRLQNQK-----VNKGNKATFEIEL-TKGDALVRWFKDGSEIQ-FSNHIQ 1153
+ P + L K V G + T E+ + ++ W K+ I FS
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHT 1128
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
G +KI + D+G Y C GN L V P R P+ + V
Sbjct: 1129 FLPSG---SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP--KIQRGPKHLKVQ 1183
Query: 1210 ANTDAYLTVEIPDETLDV-TWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L V TW K S ++ D E D TL I + T D YT
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATPSDAGIYT 1240
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIK-----RGSDVTLLVDYQAFPQPNDEW 1321
CV + T + ++ + V+ PP + D E Y + + P+P +W
Sbjct: 1241 CVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW 1300
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ N + + + SI L I V D G Y N G + + N+ + P
Sbjct: 1301 LHNGRELTG-REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Query: 1382 SPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
K + + + + + E E T + I++Y + TE +++ + +
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQVTESSTIQTVNNGK-- 1414
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNED 1498
I L + Y+ ++I+ S+ +Y+ + + + + N ++ N D
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQ--KYFNI--DVLVPPTIIGTNFPNEVSVVLNRD 1470
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCIAFND 1555
+ L C G P P + W++DGK L E Y+C N
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G+ + I P I N + + G+P P + WYK+G + +
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG---- 1671
+ +K + I + S S+ YT +N AGT+ + VY P EG
Sbjct: 1591 SSQ--ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY-VPPMIEGNLAT 1647
Query: 1672 PVIMREISRESVTIEWK 1688
P+ + + S+T+E K
Sbjct: 1648 PLNKQVVIAHSLTLECK 1664
Score = 147 bits (356), Expect = 4e-34
Identities = 238/1118 (21%), Positives = 422/1118 (37%), Gaps = 93/1118 (8%)
Query: 599 IVEAPLSDHGS-EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
I + LSD G E D+ E PP + P V G +L C +
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
++ + ++ W ++ E + +++ L++ +VK G Y + + G
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-----LELKSVKFNDAGEYHCMVSSEGG 598
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA 777
++ + L + +EPP+V K+ G V + G P+P I W N+ +
Sbjct: 599 SSAASVFLTV----QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 778 LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-AETSAVITVEEPTEENAEPPLFI 836
+ + +K KD G+Y A NS G + S + +E P + L +
Sbjct: 655 -SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLV 713
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
+ITV E + + P P + W++ + + PS + + + L+
Sbjct: 714 -ALGDITVME-------CKTSGIPPPQVKWFKGDLELRPSTFLIID---PLLGLLKIQET 762
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSH 954
++D+GDY CVA N AG+++ ++T+DV E G V L C Q
Sbjct: 763 QDLDAGDYTCVAINEAGRAT--GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Query: 955 TVSTKW--YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETST 1008
+ KW N S I + R D G C ++Q ++ T
Sbjct: 821 EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 1009 MLVVKETIPEFIRKLQDF-EVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDF 1065
+ V + I V E L + + + W ++ ++ +N Y
Sbjct: 881 TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML--LQNPYIT 938
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITRLQNQKVNKGN 1122
+ L+I + D GEY+C+ + + T T VV + P I Q +G
Sbjct: 939 VRSD--GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + V W K G I S+ DG L + +++GEY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTA 1053
Query: 1179 --EVGNSKCTAILTV-EEPSI-----NFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTW 1229
G +K LTV P + + P I V A + L E+ +TW
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 1230 YKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
K+ +I + + T + ++ I + D Y CV + V++ V P
Sbjct: 1114 AKETQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLT 1346
PKI + +++ G V + + Q P P W S ++ +H + + +L+
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEH---HVSNPDGTLS 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSSSINICW 1401
I + +DAGIY N G + E+ + + + P+ PP E ++ I +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-RIEF 1286
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
P I ++ +E+ E IS+ T I ++ + + AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILE-DGTLLVIASVTPYDNGEYICVAVNE-- 1343
Query: 1461 ISDASETTEYYKVIKETKIQSPTV---EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
A T Y + K+ P V ++ + N++ N+ L C G P P + WY+
Sbjct: 1344 ---AGTTERKYNL----KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Query: 1518 DGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
D ++ + T N Y C A N G + + + P I
Sbjct: 1397 DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
+N + + + + ++G P P++ W+K+G L + N+ ++ V+ +K
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
+R+ +Y SN AG + ++ L +Y PS G V
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553
Score = 121 bits (291), Expect = 3e-26
Identities = 205/965 (21%), Positives = 343/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 3618 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 3674
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 3675 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 3727
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 3728 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 3787
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 3788 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 3898
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 3899 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 4018 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 4074
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 4075 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 4131
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 4132 S---LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 4185
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 4242
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 4243 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 4302
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P +
Sbjct: 4303 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP-------VF 4351
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ D S W EP G + I+ V+ T +W + I+ L S
Sbjct: 4352 KGDYPS---NWIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS--- 4403
Query: 1451 FRAYAVNEVDISD-ASETTEYYKVIKET---KIQSPTV--EKPLKNITTEPNEDIELTCI 1504
Y D D T V++ + +QSP + +P++ + + I L C
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK-IILNCQ 4462
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 4523 PVIVQ 4527
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C GYP+P+I W I S ++M D TL I+ P+DAG + C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD----GTLFIKNAAPKDAGIYGC 681
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+A N+AG + L +EAP
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP 702
Score = 51.6 bits (118), Expect = 3e-05
Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V EC+ P P ITW++ +I S ++ D L I++
Sbjct: 3064 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 3120
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 3179
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 3180 PPTIAWLKNHKRIENSD-SLEVRILS 3204
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 773 VAINEAGRATGKITLDVGSP 792
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 489 NEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
++K ++ V PT + ++ V K +P V +C G P P ITW +
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKP--------VALQCIANGIPNPSITWLKDDQ 1865
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +Q V L I + EDAG +TCVA NAAG +L V P S
Sbjct: 1866 PVNTAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 4313
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF + + V+ P
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Score = 47.2 bits (107), Expect = 6e-04
Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 1658
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC+ G P P +TW + +K + + ++ + + +E+ D G + CVA
Sbjct: 1659 LTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT 1715
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q +
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI 1775
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVS 1798
Score = 47.2 bits (107), Expect = 6e-04
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G C+V+G P P I W R+ I+ S + + +L I EDAG +
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVNEDAGDY 4417
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA N AG + L +++P
Sbjct: 4418 TCVATNEAGVVERSMSLTLQSP 4439
Score = 45.6 bits (103), Expect = 0.002
Identities = 38/185 (20%), Positives = 69/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ V +++ PV + +G ++ ++G P
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFK-GDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 4379 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 1662 VYDKP 1666
+ P
Sbjct: 4436 LQSPP 4440
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 4239 CVANNAAGEDTHTVSLTV 4256
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 4044
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 4454 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 4509
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 4510 VARNLMGSVLVRVPVIVQ 4527
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 3910 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 3962
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 3963 GRYTCVARNAAGSAHRHVTLHVHEP 3987
>AL135796-1|CAI17854.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-164L12 on chromosome 1. ).
Length = 5635
Score = 235 bits (574), Expect = 2e-60
Identities = 291/1201 (24%), Positives = 482/1201 (40%), Gaps = 129/1201 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ EC+V+G P P +TW + + ++ ++ D+ ++ L ++ + D G + C
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHI--LQLKNIHVSDTGRYVC 2363
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA N AG +L V AP S G+ + P S
Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRS--------------------PENIS------ 2397
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V E + + L C IP P I W FK V N SV I S M L++
Sbjct: 2398 -VVEKNSVSLTCEASGIPLPSITW-FKDGWPVSLSN-SVRILSGGRM----LRLMQTTME 2450
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGN 761
G YT V N GE L + PP ++ L+ + V++ +SV L+ +V GN
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLV----PPHIVGENTLEDVKVKEKQSVTLTCEVTGN 2506
Query: 762 PRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P ITW K+ +P+ +A S G IT + +V G YT A + G S
Sbjct: 2507 PVPEITWHKDGQPLQEDEAHHIISGGRFLQITNV---QVPHTGRYTCLASSPAGHKSRSF 2563
Query: 819 VITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+ V PT +++TV LV P +ITW+++ + +
Sbjct: 2564 SLNVFVSPTIAGVGSD---GNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2620
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL--- 934
I G ++++ D ++G Y CVA+N AG+ V + + + L
Sbjct: 2621 NIRILPGGRTLQILNAQED---NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGP 2677
Query: 935 ---QKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
K + + T+ LEC+ + S WY + + + DH I G
Sbjct: 2678 GLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2735
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIRKLQDF--------EVKEKDVAI---- 1035
D G C+ + E V +P +KL + + KDV I
Sbjct: 2736 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 1036 -LEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L E N + + W +DG + +K G R L I V D G Y+C+ +
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPL-TSSDKVLILPGG--RVLQIPRAKVEDAGRYTCVAVN 2852
Query: 1094 ES--CTAEVTVVELPPEII----TRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSE 1145
E+ + + V L P II + L + NK+ L+ G R W KDG
Sbjct: 2853 EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2912
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
+ +H + +G+ L+I + + D G Y C G++K L V P +
Sbjct: 2913 LLEDDHHKFLSNGR--ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970
Query: 1202 LPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E + V N LT E+ D++W K + I+ ++ RTL I +
Sbjct: 2971 -SENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG--GRTLQIIRAKV 3027
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE----YRIKRGSDVTLLVDYQAFP 1315
D EYTC+ ++ +K K + V PP I D++ E ++ G+ V+L + A P
Sbjct: 3028 SDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W N ++I + H + D + L IKK E +D G Y R N G D ++
Sbjct: 3088 PPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145
Query: 1376 TILDKPS--PPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+ PS P + I+E S+ + + D TG I ++ ++ I+ ++ + V+
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDA---TGIPPPTIAWLKNHKRIENSDSLEVRI 3202
Query: 1433 IT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
++ ++ I + + S + A N + +YY + + E P ++
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNM-----EGKAQKYYFLSIQVPPSVAGAEIP-SDV 3256
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXXXXXXXX 1547
+ E++EL C G+P P + W +DGK + + + N
Sbjct: 3257 SVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3316
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIW 1606
Y C+A N GE + + + P I + ++ ++ + D + + G PPP++ W
Sbjct: 3317 YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW 3376
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
KNG L + + VIRI + S + YT ASN AG + L+V+ P
Sbjct: 3377 LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPP 3434
Query: 1667 S 1667
+
Sbjct: 3435 N 3435
Score = 215 bits (525), Expect = 1e-54
Identities = 273/1202 (22%), Positives = 469/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 1027
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 1082
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 1083 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 1125
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA N G + + L + PP++
Sbjct: 1126 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV----PPKIQR 1175
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 800 EGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+E PT E+ EPP + FQE ++ A+ T
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 1293
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + + LVI +V + D+G+Y CVA N AG +
Sbjct: 1294 -PKPTIKWLHNGRELTGREPGISILEDGTL-LVIASV-TPYDNGEYICVAVNEAGTTERK 1350
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 1351 YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTM-----LVVKETIPEFIRKLQDFEVKE 1030
G+ D G C + TS ++V TI + V
Sbjct: 1411 NNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN 1468
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ + D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 1469 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 1525
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 1586 QPIMSSSQ-ALYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 1638
Query: 1204 EFI----LVPANTDAY----LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + + + KK
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK-- 1696
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLV 1309
L I E D+ +Y CV ++K EV V PP I D + + + + L
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + ++I + K ++ + + +V NT G+Y+ N G
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 1814
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 1815 KKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQ--- 1871
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 1872 -GNL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 1926
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR-XXXXXXXXXXXXX 1545
N T + ++L C G P P +TWY+D + L + T+ NR
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDA 1986
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLT 2044
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 2045 WLKDGSPVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 1666 PS 1667
P+
Sbjct: 2104 PN 2105
Score = 209 bits (511), Expect = 7e-53
Identities = 270/1179 (22%), Positives = 456/1179 (38%), Gaps = 93/1179 (7%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 1233
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 1234 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTVE------------DLEPPYNTT 1274
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F ++ Q ++ C P+P I WL G E+ E ++I D ++L
Sbjct: 1275 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREP-GISILEDG----TLL 1323
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVI 753
I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVTNVSVLLNQLTN 1379
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439
Query: 814 AETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
++ I V P P + F E++V + L +V P P I W+++ +
Sbjct: 1440 SQKYFNIDVLVP------PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 1494 LFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Query: 933 HLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ + LEC+T + WY + + I I +G+
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611
Query: 991 XXDVGVIKCIVKDQETST--MLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-- 1046
D C V + + V +P I + ++ V + + + A
Sbjct: 1612 --DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNP 1669
Query: 1047 ---VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
+ W +DG +K N E G +KL I + D G+Y C+ + E+
Sbjct: 1670 SPILTWLKDGVPVKANDN-IRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYE 1726
Query: 1103 --VELPPEIITRLQNQK--VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
V +PP I + V N + +T + W KDG I + ++ ++
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLN 1786
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVPANTD 1213
G+K L I + + G Y C N+ K +TV P + L E ++V
Sbjct: 1787 GRK--LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
A + +TW K + +T + L R L I K +D YTCV +A
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903
Query: 1274 KSTTKLKVEV-VEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
T+ +++ V PP + D + + + V L P P W +++++
Sbjct: 1904 AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSG 1963
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N++
Sbjct: 1964 S--TSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMV 2021
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ ++ E ++ + + + V + + ++ + + + + R
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQISDTGR 2080
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 2081 YTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Query: 1511 PKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
P +TW +DG L K + ENR Y C A N G+ E + V I
Sbjct: 2133 PTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW 2192
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I S+E + G+ + GIPPP +IW K G+ + D +
Sbjct: 2193 VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR 2252
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++I ++S ++ Y+ ASN AGT+ E L+VY +P+
Sbjct: 2253 QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPT 2291
Score = 200 bits (488), Expect = 4e-50
Identities = 249/1088 (22%), Positives = 430/1088 (39%), Gaps = 92/1088 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+ S V + + LEC IP P + WL G + N +
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+L +T+ + G YT VAVN GE I L++ PP ++ +++ V ++
Sbjct: 2067 --ILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV----PPNIMGEEQNVSVLISQA 2120
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
V L Q P PT+TW K+ P+ P S + S+ ++ +V+D G YT +A N
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YRNN 870
G E + + + P L ++TV E I L+ + P P++ W + +
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIWKKKGS 2235
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKV 928
+++ S + G +L I ++ + D+ Y CVASN AG K + +V I
Sbjct: 2236 PVLTDSMGRVRILSGGR-QLQI-SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTIT 2293
Query: 929 TFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
H + T GK++ LEC+ + W + + EI+ EG
Sbjct: 2294 NSGSHPTEIIVT-RGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQL 2350
Query: 987 XXXXXXDVGVIKCI------VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + D++ + +I R ++ V EK+ L E
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 1041 NS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ESC 1096
+ + W +DG + N G R L + T++ D G+Y+C++R+ E
Sbjct: 2411 SGIPLPSITWFKDGWPVS-LSNSVRILSGG--RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467
Query: 1097 TAEVTVVELPPEII--TRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQ 1153
V +PP I+ L++ KV + T E+T + W KDG +Q
Sbjct: 2468 KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHH 2527
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSIN--FTLRLPEFI 1206
+ G+ L+I + + G Y+C + S+ ++ P+I + PE +
Sbjct: 2528 IISGGR--FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV 2585
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V N+ L E +TW+K + +E ++ RTL I ED+
Sbjct: 2586 TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG--GRTLQILNAQEDNAGR 2643
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVD---------YEREYRIKRGSDVTLLVDYQAFPQ 1316
Y+CV + EV + P I++ +E +IK + +TL + A P
Sbjct: 2644 YSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPS 2703
Query: 1317 PNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+ W + + +K H +I + +L IK+ + +D G Y N G +++ +V
Sbjct: 2704 ASLSWYKDGQPLKSDDHV--NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVN 2761
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENT--GNSTIIYYVVEYQEIDTTEWISVKN-I 1433
I PP + EI + E ++ N +Y T W + +
Sbjct: 2762 I---QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 1434 TKTQ----------TSIQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQSP 1482
T + I K + R+ AVNE ++ +Y +V+ I+
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA----GEDSLQYDVRVLVPPIIKGA 2874
Query: 1483 TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXX 1540
+ P + +T N+ + C+ G P P+ +W +DG+ L N
Sbjct: 2875 NSDLP-EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQKP-VITISNEDIKQKHKVGDEWLVTAVIEGI 1599
Y C+A N G + + + P VI +E++ V + +T + G
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV--VVNNFISLTCEVSGF 2991
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
PPP++ W KN ++ + I +T ++I K S +YT A N AG S + +
Sbjct: 2992 PPPDLSWLKNEQPIKLNTNTLIVPGGRT--LQIIRAKVSDGGEYTCIAINQAGESKKKFS 3049
Query: 1660 LKVYDKPS 1667
L VY PS
Sbjct: 3050 LTVYVPPS 3057
Score = 197 bits (481), Expect = 3e-49
Identities = 269/1219 (22%), Positives = 480/1219 (39%), Gaps = 120/1219 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S ++ EC+ G P P ITW++ I S +Y D + +V D+ T+TC
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQ-ALYIDKGQYLHIPRAQV--SDSATYTCH 1619
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
N AG A + + V P ++EG T P +
Sbjct: 1620 VANVAGTAEKSFHVDVYVP-----------------------PMIEGNLAT----PLNKQ 1652
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + LEC+ P P + WL G + ++NI + L+I + ++
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK------LEIMSAQEID 1706
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGNP 762
G Y VA + GE + K + PP + + IV + L V G+P
Sbjct: 1707 RGQYICVATSVAGEKEI----KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 763 RPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
PTI W K+ + + ++ +V + G+Y A N+ G + +TV
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE-TITQ 881
P P + + E V + + L P PSITW ++++ ++ ++ +
Sbjct: 1823 HVP------PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-ET 940
G +++ T ++ D+G Y CVA+N+AG++ + + V + ++ K ET
Sbjct: 1877 QSSGRVLQIAKTLLE---DAGRYTCVATNAAGETQQ--HIQLHVHEPPSLEDAGKMLNET 1931
Query: 941 E-EGKTVILECQTS-HTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
V LEC+ + + V WY + + +SG + G+ D G+
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS--DAGIY 1989
Query: 998 KCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDG 1053
KC+ + +T L + P V + LE E A + W +DG
Sbjct: 1990 KCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ N G I L + + + D G Y+C+ + + + + V +PP I+
Sbjct: 2050 SPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107
Query: 1111 TRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
QN V L + DA+ + W KDG + L+I + LKI
Sbjct: 2108 GEEQNVSVLISQAVEL---LCQSDAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKIE 2162
Query: 1167 DCDLDDAGEYSCEVGN--SKCTAILTVE---EPSINFTLRLPEFILVPANTDAYLTVEIP 1221
D + D G Y+CE N K V P+I + L + ++ N + L
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSG 2222
Query: 1222 DETLDVTWYKKKS-VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
++ W KK S V+ D+ + ++S R L I + D Y+CV + T K
Sbjct: 2223 IPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 1280 KVEV-VEFPPKIVD---YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ + V P I + + E + RG ++L + Q P P W+ + + K K +
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE 2340
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK----PNILE 1391
I + L +K + +D G Y N G D + ++++ PS G NI
Sbjct: 2341 --ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISV 2398
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRF 1451
++ +S+++ E +I ++ + +S+ N + + + L+ +
Sbjct: 2399 VEKNSVSLTC-EASGIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTME 2450
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVP 1509
A V + A E K+ + + P + E L+++ + + + LTC G P
Sbjct: 2451 DAGQYTCVVRNAAGEER---KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP 2507
Query: 1510 QPKVTWYRDGKKLKTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
P++TW++DG+ L+ +A + Y C+A + G S + +
Sbjct: 2508 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Query: 1568 QQKPVIT-ISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTK 1624
P I + ++ + V + V E PP + W+K+G LE+++ I
Sbjct: 2568 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2627
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+T ++I + ++ +Y+ A+N AG +KVY P +G + +S + V
Sbjct: 2628 GRT--LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVK 2685
Query: 1685 IEWKPPLDDGGLELTKYAI 1703
I+ L LE YAI
Sbjct: 2686 IKVNNTLT---LECEAYAI 2701
Score = 196 bits (477), Expect = 9e-49
Identities = 270/1212 (22%), Positives = 474/1212 (39%), Gaps = 118/1212 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 890
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 891 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 944
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 945 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 993
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P ++ G Y
Sbjct: 994 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYV 1050
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P + L ++ EI+V + L V P P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 1167
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXX 983
V ++ K + + G+ V + C T +K + + E
Sbjct: 1168 HVPPK--IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225
Query: 984 XXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILE 1037
D G+ C+ + ET L V+E P + L+ ++ VA
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQR 1283
Query: 1038 VEI-----NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
+E + + W +G + ++ + G + L I + + +D GEY C+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAV 1341
Query: 1093 DESCTAEVTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSE 1145
+E+ T E V +PP I + Q V N+ E+E T ++ W+KD +
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQ 1400
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLR 1201
+ S+ IQ +GK LK++ +DAG YSC+ G S+ + V P
Sbjct: 1401 VTESSTIQTVNNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 1202 LPEFILVPANTDAYLTVEIPDETL-DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P + V N D L ++ D+ W+K K + L+ + + L ++
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD--RGQVLHLKNAR 1516
Query: 1260 EDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFP 1315
+D+ Y C + +A K +K+ + PP I + + + S + L + + P
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKL-TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLP 1575
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W + + I ID K L I + + +D+ Y + N G A+ +V
Sbjct: 1576 MPAITWYKDGQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVK 1431
+ P G N+ + + I E + GN S I+ ++ + + +
Sbjct: 1634 DVYVPPMIEG--NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAND----- 1686
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLK 1489
NI + + + L+ S+ V S A E Y+V + P +E
Sbjct: 1687 NI-RIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETS 1742
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXX 1547
N +EL C G P P + W +DG+ + + N
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGL 1802
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C+A N G+ + V + P I S +E + K+K + + GIP P +
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSIT 1859
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+ + N + N+ + V++I + + +YT A+N AG + + L V++
Sbjct: 1860 WLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Query: 1666 PSKPEGPVIMRE 1677
PS + ++ E
Sbjct: 1919 PSLEDAGKMLNE 1930
Score = 193 bits (470), Expect = 7e-48
Identities = 242/1089 (22%), Positives = 423/1089 (38%), Gaps = 92/1089 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C + P I W G + + NI + L+I N ++ G Y+ VA
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGG------RTLQILNAQEDNAGRYSCVA 2648
Query: 713 VNREGEASLPIVLK------IKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
N GE +K I G+ P + P K + ++ ++ L + P ++
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPG-LSP-KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 767 TWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+W K+ +P+K+ + H++ I K ++ D G YT A N G E + ++ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQI-KEAQISDTGRYTCVASNIAGEDELDFDVNIQVP 2765
Query: 826 T--EENAEPPLFINRFQEITVKE---KGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
++ E ++ + K+ I L P P++TWY++ ++ S+ +
Sbjct: 2766 PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVL 2825
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS--HGARVTIDVEKVTFVKHLQKSY 938
G +++ V+ D+G Y CVA N AG+ S + RV + L +
Sbjct: 2826 ILPGGRVLQIPRAKVE---DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEV 2882
Query: 939 ETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
K+ ++EC +S + + + W + + + DH + + GR D+G
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGR 2940
Query: 997 IKCIVKDQETSTMLVVKETI---PEFIR-KLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
C+ ++ S + P I K ++ V + L E++ D+ W +
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPE 1108
+ + IK N G R L I V D GEY+CI +++ ++ V +PP
Sbjct: 3001 NEQPIKLNTNTL-IVPGG--RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 1109 IITR----LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
I L V +G + E E ++ W+K+G I S H+++ DG Q L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QML 3115
Query: 1164 KIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I ++ D G+Y C N K + PSI R E I+ + LT
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTC 3173
Query: 1219 E---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ IP T + W K IE+++ + L I + D YTC+ + +
Sbjct: 3174 DATGIPPPT--IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Query: 1276 TT-KLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
K ++ PP + E + + G +V L+ + P P +W+ + K I +
Sbjct: 3232 KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN---- 1388
+ + + ++L I +D G Y N G D N+ + P+ G +
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
++ + +SINI E TG W+ + I+ L
Sbjct: 3352 LMTLVDTSINI---ECRATGTPP-----------PQINWLKNGLPLPLSSHIRLLAAGQV 3397
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTC 1503
R V++V + + K +Q P ++ + + IT + C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 1504 IFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVET 1561
I G P P + W RDG+ L A T Y CIA N+ GEV
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3517
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
++ + + P I S E + V + +T + GIP P++ W K+G L + +
Sbjct: 3518 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--V 3575
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREIS 1679
T V+RI + + +YT AS+ AG E ++V+ P + + P + +
Sbjct: 3576 QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR 3635
Query: 1680 RESVTIEWK 1688
VT+E K
Sbjct: 3636 NRQVTLECK 3644
Score = 184 bits (449), Expect = 2e-45
Identities = 262/1206 (21%), Positives = 456/1206 (37%), Gaps = 135/1206 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G+ + C+ G P P + W ++ + ++ S + I E DA +
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE--KSDAALY 2267
Query: 582 TCVAKNAAGFASS--TTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
+CVA N AG A ++ + +++ GS T ++ +GIPP
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPP----- 2321
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P ++ +G ++ KG EI+ DE +L++ N
Sbjct: 2322 PTVTWMKDGHPLIKA---------------KGVEIL-DEG-------------HILQLKN 2352
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS---MIVRQGESVILSA 756
+ G Y VAVN G L + PP +I +S + V + SV L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHA----PPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ G P P+ITW K+ PV + + L ++D G YT N+ G
Sbjct: 2409 EASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK 2468
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
++V P E N +++ VKEK ++ L VT NPVP ITW+++ + +
Sbjct: 2469 IFGLSVLVPPHIVGE-----NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQED 2523
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E G ++ ITNV +G Y C+AS+ AG S + + V + +
Sbjct: 2524 EAHHIISGGRFLQ--ITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPT--IAGVGS 2578
Query: 937 SYETEEGKTVILECQTS--------HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
E+ TVIL TS + W+ + + + I+ GR
Sbjct: 2579 DGNPED-VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRK-------LQDFEVKEK--DVAILE 1037
+ G C+ ++ E VK IP I K L EVK K + LE
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1038 VEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
E + +A + W +DG+ +K + + GH L I+ + D G Y+C+ + +
Sbjct: 2696 CEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2752
Query: 1097 TAEVTV---VELPPEI--ITRLQNQKVNKGNKATFEIELTKGDAL-----------VRWF 1140
E+ +++PP + + N N ++ + +L + W+
Sbjct: 2753 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI 1196
KDG + S+ + + G+ L+I ++DAG Y+C E G + V P I
Sbjct: 2813 KDGHPLTSSDKVLILPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Query: 1197 --NFTLRLPEFILVPANTDAYL-TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
LPE + V N A + + +W K + + + +S+ R L
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSN--GRIL 2928
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE-YRIKRGSDVTLLVDY 1311
I D Y CV + + K + V PP ++ + E + + ++L +
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
FP P+ W+ N + IK +T I +L I + + +D G Y N G +
Sbjct: 2989 SGFPPPDLSWLKNEQPIK--LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWIS 1429
+ ++T+ PS I + DS S+++ N T + E + W
Sbjct: 3047 KFSLTVYVPPS------IKDHDSESLSVV-----NVREGTSVSLECESNAVPPPVITWYK 3095
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEK 1486
+ T ++ L + V++ + K + P++E
Sbjct: 3096 NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEG 3155
Query: 1487 PLKNITTEP-NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXX 1541
P + + E + + LTC G+P P + W ++ K+++ + +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ 3215
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y CIA N G+ + + IQ P + + +G+ + GIP
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W K+G + + + I S + I S + KYT A+N AG L
Sbjct: 3276 PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 1662 VYDKPS 1667
VY P+
Sbjct: 3336 VYVTPT 3341
Score = 180 bits (439), Expect = 4e-44
Identities = 241/1193 (20%), Positives = 429/1193 (35%), Gaps = 91/1193 (7%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+T+ EC+ P ++W++ +K + N TL I+E D G +TCV
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---NGHTLQIKEAQISDTGRYTCV 2746
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG ++ ++ P S ++L+ + +A+
Sbjct: 2747 ASNIAGEDELDFDVNIQVPPS-------------FQKLWEIGNMLDT-----GRNGEAKD 2788
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + I L C A P P + W G + + + + VL+I K
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG------RVLQIPRAKVED 2842
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G YT VAVN GE SL +++ + + + V +S ++ G+P P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAP 2902
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+W K+ +P+ I + ++ D G Y AEN+ G A+ + V
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV 2962
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P P + + + +TV I L V+ P P ++W +N + I +
Sbjct: 2963 P------PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG 3016
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET---E 941
G ++++ V D G+Y C+A N AG+S +T+ V + H +S
Sbjct: 3017 GRTLQIIRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPP-SIKDHDSESLSVVNVR 3072
Query: 942 EGKTVILECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
EG +V LEC+++ WY N + I+ H EI+ +G+ V +
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 1000 IV---KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
I +D + + V E + E V + + W ++ + I
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRL 1113
+ + + KL I + D G Y+CI + A+ +++PP +
Sbjct: 3193 E-NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 3251
Query: 1114 QNQKVNKGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
V+ E+ L++W KDG I ++ + L IY
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 1171 DDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D G+Y+C N + + P+I E ++ +T +
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 1226 -DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + + L++ + + I + D YTCV + +
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429
Query: 1285 EFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
F P +D E + +GS ++ P P+ W+ + + + H ++ +
Sbjct: 3430 VFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL--TVSTH 3487
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
L + K E D+G Y N G + +L+ P G EI S +N
Sbjct: 3488 GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVIVN--- 3543
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD- 1460
N T I + ++ W+ +Q L R V +
Sbjct: 3544 ----NPLELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGR 3596
Query: 1461 -----ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
S A + + Y V ++P ++IT N + L C VP P +TW
Sbjct: 3597 YTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 1516 YRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
R+G++L+ Y C+A N G+ ++ + P I
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNI 3715
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRI 1632
+ + + ++ + EG+P P + W K+G L N Y+I + + I
Sbjct: 3716 KGGPQSLVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---ENGFLHI 3770
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ + + +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 3823
Score = 178 bits (434), Expect = 2e-43
Identities = 266/1185 (22%), Positives = 444/1185 (37%), Gaps = 112/1185 (9%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
++ +C V G P P I W + +I F++ N LVI + + G + C+A
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL---NGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 587 NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ-YV 645
N AG DH E V +PPT ++ V
Sbjct: 1809 NTAG---------------DHKKEFEVTVH---------------VPPTIKSSGLSERVV 1838
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ + L+C IP P I WL K ++ V ++ I+S VL+I
Sbjct: 1839 VKYKPVALQCIANGIPNPSITWL-KDDQPVNTAQGNLKIQSSGR----VLQIAKTLLEDA 1893
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGESVILSAQVVGNPR 763
G YT VA N GE I L + EPP + + K + V V L + GNP
Sbjct: 1894 GRYTCVATNAAGETQQHIQLHVH----EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPV 1949
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P ITW K+N+ + + + + I ++ ++ D G+Y A NS G E + V
Sbjct: 1950 PVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVH 2009
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
P + V ++L P PS+TW ++ +S Q
Sbjct: 2010 -------VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL 2062
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
G I L +T+ D+G Y CVA N+AG+ + + V + S +
Sbjct: 2063 SGGRI-LALTSAQIS-DTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA 2120
Query: 944 KTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++ + + W + + I E R D G C +
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLS-ISENR-SVLKIEDAQVQDTGRYTCEATN 2178
Query: 1004 --QETSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEINS-ETADVVWERDGE-II 1056
+T V +P I +L V E ++ L E + +++W++ G ++
Sbjct: 2179 VAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRL 1113
+ G R+L I D YSC+ + + TA+ V + P I
Sbjct: 2239 TDSMGRVRILSGG--RQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSG 2296
Query: 1114 QNQK---VNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
+ V +G + E E+ V W KDG + + +++ +G +LK +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLK--NIH 2354
Query: 1170 LDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G Y C N K + PSI R PE I V LT E
Sbjct: 2355 VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIP 2414
Query: 1225 L-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK-STTKLKVE 1282
L +TW+K + + ++S R L + + T +D +YTCV+ +A K+
Sbjct: 2415 LPSITWFKDGWPVSLSNSVRILSG--GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 1283 VVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V PP IV + ++K VTL + P P W + + ++ + I S
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ--EDEAHHIIS 2530
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSS 1395
L I V+ G Y + GH ++ + P+ G P + + +
Sbjct: 2531 GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
S E + +TI ++ + +++ I + +T I N + +++ R+ A
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-KDGTPLESNRNIRILPGGRT-LQILNAQEDNAGRYSCVA 2648
Query: 1456 VNEV-DISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
NE ++ E Y +I + + P + K + + N + L C +P +
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSP--KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 1514 TWYRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+WY+DG+ LK+ N Y C+A N GE E V IQ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 1572 ----VITISNE-DIKQKHKVGDEWLVTAV-----IEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ I N D + + D + + PPP + WYK+G+ L + + I
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLI 2826
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ V++I K + +YT A N AG S++ ++V P
Sbjct: 2827 LPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Score = 176 bits (429), Expect = 6e-43
Identities = 262/1150 (22%), Positives = 439/1150 (38%), Gaps = 122/1150 (10%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLV 658
+ A +SD G T D+ +PP + + V + L C+
Sbjct: 2070 LTSAQISDTG-RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSD 2128
Query: 659 AIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE 718
AIP P + WL G ++ +S++ SVLKI + + G YT A N G+
Sbjct: 2129 AIPPPTLTWLKDGHPLLKKPGLSISENR------SVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 719 ASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
+ I PP + + L + V +G + L + G P P + W K PV
Sbjct: 2183 TEKNYNVNIWV----PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 777 A-----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE-EPTEENA 830
+ S G I+I + D +Y+ A N G A+ + V PT N+
Sbjct: 2239 TDSMGRVRILSGGRQLQISIAEK---SDAALYSCVASNVAGTAKKEYNLQVYIRPTITNS 2295
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
+ EI V +I L V P P++TW ++ + ++ + +G ++L
Sbjct: 2296 G-----SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQL 2350
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQ-KSYETEEGKTVILE 949
+V D+G Y CVA N AG + +++ H ++ E +V L
Sbjct: 2351 KNIHVS---DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 950 CQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--E 1005
C+ S S W+ + +S + I+ GR D G C+V++ E
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNSVRILSGGR--MLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 1006 TSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKN 1061
+ + +P I L+D +VKEK L E+ + ++ W +DG+ ++ +
Sbjct: 2466 ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDE 2524
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELP----------P 1107
+ G R L I N V G Y+C+ +S + + V P P
Sbjct: 2525 AHHIISGG--RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNP 2582
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
E +T + N + +A + A + WFKDG+ ++ + +I++ G+ L+I +
Sbjct: 2583 EDVTVILNSPTSLVCEA-----YSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 1168 CDLDDAGEYSCEVGNSKCTAILTVE-----EPSIN----FTLRL-PEFILVPANTDAYLT 1217
D+AG YSC N I E P IN + L P+ + + N L
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1218 VE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E IP +L +WYK ++ + + ++ TL I++ D YTCV +
Sbjct: 2696 CEAYAIPSASL--SWYKDGQPLKSDDHVNIAAN--GHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 1275 STTKLKVEV-VEFPP---------KIVDYEREYRIKR---GSDVTLLVDYQAFPQPNDEW 1321
+L +V ++ PP ++D R K + ++L + A P P W
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K I L I + + DAG Y N G ++ +V +L P
Sbjct: 2812 YKDGHPL--TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Query: 1382 SPPGKPNILE------IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK 1435
G + L ++ S++ C ++ E D +++S I +
Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQ 2929
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N + R+ A N A +Y+ + + + +N+T
Sbjct: 2930 ----ILNTQITDIGRYVCVAEN-----TAGSAKKYFNL--NVHVPPSVIGPKSENLTVVV 2978
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
N I LTC G P P ++W ++ + KL T Y CIA
Sbjct: 2979 NNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGN 1611
N GE + + + P I + + V + V+ E +PPP + WYKNG
Sbjct: 3039 NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGR 3098
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS--KP 1669
+ I + ++ IK+ + S + +Y A N AG L VY PS P
Sbjct: 3099 MITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGP 3156
Query: 1670 EGPVIMREIS 1679
E VI+ IS
Sbjct: 3157 EREVIVETIS 3166
Score = 173 bits (422), Expect = 4e-42
Identities = 232/1115 (20%), Positives = 425/1115 (38%), Gaps = 83/1115 (7%)
Query: 594 STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL 653
S L +E G E T ++ + PT + EG + L
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTL 1000
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C+ P+P + W KGE ++ + + +D +Y + + + G Y A
Sbjct: 1001 PCKASGNPKPSVIWSKKGE-LISTSSAKFSAGADGSLY-----VVSPGGEESGEYVCTAT 1054
Query: 714 NREGEASLPIVLKIKT-----GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
N G A + L + G++ +P++ ++ GE V L +V P P ITW
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITW 1113
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
K + + + + + D G+Y A N G + + V P +
Sbjct: 1114 AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNFDGEN 887
P + ++ V ++ I A+ T P+P ITW + ++ E N DG
Sbjct: 1174 QRGP-----KHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHHVSNPDGT- 1225
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE-----E 942
L I D+G Y CVA+N AG +T+ V++ V+ L+ Y T
Sbjct: 1226 --LSIDQATPS-DAGIYTCVATNIAGTDE--TEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 943 GKTVILECQTSHTV--STKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ + C T + KW HN +E++G + I+++G D G C
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG--TLLVIASVTPYDNGEYIC 1338
Query: 1000 IVKDQETST--MLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVV-WERDG 1053
+ ++ +T +K +P I+ ++ + V + L E+ + ++ W +D
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ + + G I KL+ + D G YSC + + T++ V +PP II
Sbjct: 1399 VQVT-ESSTIQTVNNGKILKLF--RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 1111 -TRLQNQ-KVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T N+ V E ++ KG + WFKDG + F + + + Q L +
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLK 1513
Query: 1167 DCDLDDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
+ +D G Y C V N+ LT+ P + I V N+ L E
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 1223 ETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ +TWYK I + + I K + L I + D YTC + + T +
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Query: 1282 EVVEFPPKIVDYEREYRIKR----GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V + P +++ + + +TL P P W+ + +K + +
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-- 1689
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
I++ L I + D G Y + G +++ V +L P+ G
Sbjct: 1690 IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 1398 NICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
N+ + TG+ I ++ + Q ID + + + + I + +++ +R A
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N ++ K + T PT++ L + + L CI G+P P +TW
Sbjct: 1809 NTAG--------DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW 1860
Query: 1516 YRDGKKLKTAKATYENRXX---XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+D + + TA+ + + Y C+A N GE + + + + P
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + + + + V + + G P P + WYK+ L ++T + +I I
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGST--SMTFLNRGQIIDI 1978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + S + Y A N+AG + + +L+V+ PS
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 173 bits (421), Expect = 6e-42
Identities = 252/1208 (20%), Positives = 458/1208 (37%), Gaps = 111/1208 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S C+ YP ITWF+ ++ +++ ++ TL I ++AG ++CV
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PGGRTLQILNAQEDNAGRYSCV 2647
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG E+ V P + ++ P S PK
Sbjct: 2648 ATNEAGEMIKHYEVKVYIPPIINKGDLW--------------------GPGLS--PKEVK 2685
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+ + + LEC AIP ++W G+ + D+++++A L+I +
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH------TLQIKEAQISD 2739
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP--QVIEPLKSMIV--RQGES--------V 752
G YT VA N GE L + I+ PP Q + + +M+ R GE+ +
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNIQV----PPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L + P PT+TW K+ P+ + + + KV+D G YT A N G
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Query: 813 IAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ V P N++ P +E+TV + + + +P P +W ++
Sbjct: 2856 EDSLQYDVRVLVPPIIKGANSDLP------EEVTVLVNKSALIECLSSGSPAPRNSWQKD 2909
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + + +G ++++ T + D G Y CVA N+AG + + + V +
Sbjct: 2910 GQPLLEDDHHKFLSNGRILQILNTQIT---DIGRYVCVAENTAGSAKKYFNLNVHVPP-S 2965
Query: 930 FVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ ++ + L C+ S W N++ I + I+ GR
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 988 XXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR-----KLQDFEVKEKDVAILEVEI 1040
D G CI +Q E+ + +P I+ L V+E LE E
Sbjct: 3026 KVS--DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES 3083
Query: 1041 NSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N+ V+ W ++G +I + E + L+I+ V D G+Y C + + +
Sbjct: 3084 NAVPPPVITWYKNGRMITESTH---VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Query: 1100 VTV---VELPPEIITRLQNQKVNK-GNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQL 1154
V +PP I + V N T + T + W K+ I+ S+ +++
Sbjct: 3141 KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEV 3200
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPA 1210
I KL+I D+G Y+C N + A L+++ P +P + V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL 3260
Query: 1211 NTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ L T + W K I E + TL I D +YTCV
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--PQPNDEWIVNS 1325
+ + + V P + + ++ D ++ ++ +A P P W+ N
Sbjct: 3321 ATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP- 1384
+ H + + + + I + + +D +Y N G + N+ + P+
Sbjct: 3381 LPLPLSSHIR--LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDN 3438
Query: 1385 --GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
G I + SS ++ S + ++ + Q + ++V +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMV-LQLLK 3495
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYY--KVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+T S ++ A NE A E ++++ KV++ I + + I P +E
Sbjct: 3496 AETEDSGKYTCIASNE-----AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP---LE 3547
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
LTCI G+P PK+TW +DG+ L T Y C+A + G+
Sbjct: 3548 LTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGD 3607
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ +V + P I ++E + + + +PPP + W +NG +L+
Sbjct: 3608 DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR 3667
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
I + + ++I ++ YT ASN AG ++ E L V P+ GP + +
Sbjct: 3668 VRILSGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVIL 3725
Query: 1679 SRESVTIE 1686
+S +E
Sbjct: 3726 LNKSTVLE 3733
Score = 165 bits (402), Expect = 1e-39
Identities = 238/1078 (22%), Positives = 414/1078 (38%), Gaps = 81/1078 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 847
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 906
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 962
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 1015 SKKGELISTSSAKFSAGADG---SLYVVSPGGE-ESGEYVCTATNTAGYAKRKVQLTVYV 1070
Query: 926 EKVTF--VKHLQKSYETE----EGKTVILECQTSHTVS--TKWYHNKKEISGMDHREIIQ 977
F + L + E G+ V L C+ W + IS R
Sbjct: 1071 RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL 1130
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVA 1034
D G+ C+ + + VK + P+ R + +V+
Sbjct: 1131 P--SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ V+ W + G + + G L I + D G Y+C+ +
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATN 1245
Query: 1094 ESCTAEV----------TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ T E TV +L P T Q + N+ + + T ++W +G
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KPTIKWLHNG 1304
Query: 1144 SEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
E+ I + DG L I D GEY C E G ++ L V P +
Sbjct: 1305 RELTGREPGISILEDG--TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIK 1362
Query: 1199 TLRLPEFILVPAN--TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIR 1256
+ V N T+ + VE + + WYK ++ TE T+ + + L +
Sbjct: 1363 DKEQVTNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDN--VQVTESSTIQTVNNGKILKLF 1419
Query: 1257 KCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQA 1313
+ T +D Y+C ++ T++ + V PP I+ ++ E + DV L +
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKG 1479
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P P+ W + K + +D + L +K D G Y+ + N G ++
Sbjct: 1480 TPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+TI PS G +I ++ E E G I + + Q I ++
Sbjct: 1539 KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS--QALY 1596
Query: 1433 ITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
I K Q I + + S + + N ++ +E + + V I+ + PL N
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVAN---VAGTAEKSFHVDVYVPPMIEG-NLATPL-NK 1651
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYK 1549
+ L C G P P +TW +DG +K Y
Sbjct: 1652 QVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYI 1711
Query: 1550 CIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
C+A + GE E V + P I +E V + + + G PPP ++W K+
Sbjct: 1712 CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD 1771
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
G ++ + I + V I + + S++ Y A+NTAG E + V+ P+
Sbjct: 1772 GQLIDERDGFKILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 164 bits (399), Expect = 3e-39
Identities = 241/1072 (22%), Positives = 409/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 3301
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M +
Sbjct: 3302 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD- 3357
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 3358 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 3418 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 3473 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 3524
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3584
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 3585 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3699
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 3757
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 3758 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 3813
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3871
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 3932 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 3989
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 3990 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 4040
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 4159 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 4214
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 4215 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4266
Score = 160 bits (389), Expect = 4e-38
Identities = 222/1029 (21%), Positives = 397/1029 (38%), Gaps = 84/1029 (8%)
Query: 680 ISVAIESDMHMYCSV-LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+++ ++ + SV L I V EG Y +AV+ G + EPP VI
Sbjct: 468 VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS----EPPPVI 523
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKV 797
+ ++ V GE +L+ ++ +TW +N++ V+ A P + + LK K
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF 583
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y + G + S +TV+EP + P + Q T + + ++ T
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP-----KNQSFTGGSE--VSIMCSAT 636
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P I W N+ I S DG L I N + D+G Y C+ASNSAG
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG---TLFIKNAAPK-DAGIYGCLASNSAGTDKQ 692
Query: 918 GARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHRE 974
+ + I+ K+ V Q G ++EC+TS KW+ E+
Sbjct: 693 NSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF-- 747
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+I + D G C+ ++ T + + + P FI++ D ++
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807
Query: 1032 DVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
L + + W R D I + + L+I N D+G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 1090 ILRDE--SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDALV--RWFKD 1142
++ +E TV + P I V +G + T L G+ + RW K+
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-----NSKCTAILTVEEPSIN 1197
+ + + +I + DG L I L D GEY+C N+K T+++ P+I
Sbjct: 928 SAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 1198 FTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLII 1255
++ I +P + + V W KK +I + KF+ +D +L +
Sbjct: 985 HGQQILSTIEGIPVTLPCKAS---GNPKPSVIWSKKGELISTSSAKFSAGAD---GSLYV 1038
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER--------EYRIKRGSDVT 1306
++ EY C + K KV++ V P++ +R E + G +VT
Sbjct: 1039 VSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
L + ++ P P W +++I + S S+ I + +D+G+Y N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKITETRTSDSGMYLCVATNIA 1156
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G+ + + + P P L++ + D P N + + V+ + + +T
Sbjct: 1157 GNVTQAVKLNVHVPPKIQRGPKHLKV---QVGQRVDIPCNAQGTPL--PVITWSKGGSTM 1211
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE- 1485
+ ++ ++ + Y +I+ E TE ++E PTVE
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE-TEITLHVQE----PPTVED 1266
Query: 1486 -KPLKNITTE---PNEDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXX 1538
+P N T + N+ IE C G P+P + W +G++L + + E+
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIA 1326
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N+ G E + + PVI + + + +EG
Sbjct: 1327 SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P ++WYK + ++ + I T ++++ + +Y+ +A N AGTS
Sbjct: 1387 TPSPIIMWYK--DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 1659 TLKVYDKPS 1667
+ V P+
Sbjct: 1445 NIDVLVPPT 1453
Score = 151 bits (367), Expect = 2e-35
Identities = 241/1167 (20%), Positives = 421/1167 (36%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 3506
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 3561
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 3562 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 3592
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 3593 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 3647
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 3648 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 3708 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 3760
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 3761 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 3817
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 3878 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 3937
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 3938 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3994
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4050
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 4106
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S +L I D YTC+ + S+T K
Sbjct: 4107 PPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4162
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 4163 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 4218
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 4219 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 4267
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 4268 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4324
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K I ++ P V K + EP + L C G P P + W
Sbjct: 4325 TYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN 4384
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 4445 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 4499
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 4500 QKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 149 bits (362), Expect = 8e-35
Identities = 233/1097 (21%), Positives = 389/1097 (35%), Gaps = 84/1097 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + PK Q GS++ + C P+P IAW IV + SD
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT--SD----- 663
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N G Y +A N G L+ E P+++ ++V G+
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRY----IEAPKLMVVQSELLVALGDIT 719
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G P P + W K + ++ + ++ + D G YT A N G
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NN 870
A + V PP+FI +++++ + L V P P+I W R N
Sbjct: 780 RATGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I S +++ L I N+ + D G Y C A N GK VT+
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ EG+ + L C + +W N + + + +G
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
+ + V T VV +P Q E L + + +
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPS 1011
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
V+W + GE+I K+ G LY+ + + GEY C + + A+ V V
Sbjct: 1012 VIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 1104 ELPPEII---TRLQNQK-----VNKGNKATFEIEL-TKGDALVRWFKDGSEIQ-FSNHIQ 1153
+ P + L K V G + T E+ + ++ W K+ I FS
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHT 1128
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
G +KI + D+G Y C GN L V P R P+ + V
Sbjct: 1129 FLPSG---SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP--KIQRGPKHLKVQ 1183
Query: 1210 ANTDAYLTVEIPDETLDV-TWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L V TW K S ++ D E D TL I + T D YT
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATPSDAGIYT 1240
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIK-----RGSDVTLLVDYQAFPQPNDEW 1321
CV + T + ++ + V+ PP + D E Y + + P+P +W
Sbjct: 1241 CVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW 1300
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ N + + + SI L I V D G Y N G + + N+ + P
Sbjct: 1301 LHNGRELTG-REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Query: 1382 SPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
K + + + + + E E T + I++Y + TE +++ + +
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQVTESSTIQTVNNGK-- 1414
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNED 1498
I L + Y+ ++I+ S+ +Y+ + + + + N ++ N D
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQ--KYFNI--DVLVPPTIIGTNFPNEVSVVLNRD 1470
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCIAFND 1555
+ L C G P P + W++DGK L E Y+C N
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G+ + I P I N + + G+P P + WYK+G + +
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG---- 1671
+ +K + I + S S+ YT +N AGT+ + VY P EG
Sbjct: 1591 SSQ--ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY-VPPMIEGNLAT 1647
Query: 1672 PVIMREISRESVTIEWK 1688
P+ + + S+T+E K
Sbjct: 1648 PLNKQVVIAHSLTLECK 1664
Score = 147 bits (356), Expect = 4e-34
Identities = 238/1118 (21%), Positives = 422/1118 (37%), Gaps = 93/1118 (8%)
Query: 599 IVEAPLSDHGS-EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
I + LSD G E D+ E PP + P V G +L C +
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
++ + ++ W ++ E + +++ L++ +VK G Y + + G
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-----LELKSVKFNDAGEYHCMVSSEGG 598
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA 777
++ + L + +EPP+V K+ G V + G P+P I W N+ +
Sbjct: 599 SSAASVFLTV----QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 778 LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-AETSAVITVEEPTEENAEPPLFI 836
+ + +K KD G+Y A NS G + S + +E P + L +
Sbjct: 655 -SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLV 713
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
+ITV E + + P P + W++ + + PS + + + L+
Sbjct: 714 -ALGDITVME-------CKTSGIPPPQVKWFKGDLELRPSTFLIID---PLLGLLKIQET 762
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSH 954
++D+GDY CVA N AG+++ ++T+DV E G V L C Q
Sbjct: 763 QDLDAGDYTCVAINEAGRAT--GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Query: 955 TVSTKW--YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETST 1008
+ KW N S I + R D G C ++Q ++ T
Sbjct: 821 EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 1009 MLVVKETIPEFIRKLQDF-EVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDF 1065
+ V + I V E L + + + W ++ ++ +N Y
Sbjct: 881 TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML--LQNPYIT 938
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITRLQNQKVNKGN 1122
+ L+I + D GEY+C+ + + T T VV + P I Q +G
Sbjct: 939 VRSD--GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + V W K G I S+ DG L + +++GEY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTA 1053
Query: 1179 --EVGNSKCTAILTV-EEPSI-----NFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTW 1229
G +K LTV P + + P I V A + L E+ +TW
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 1230 YKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
K+ +I + + T + ++ I + D Y CV + V++ V P
Sbjct: 1114 AKETQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLT 1346
PKI + +++ G V + + Q P P W S ++ +H + + +L+
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEH---HVSNPDGTLS 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSSSINICW 1401
I + +DAGIY N G + E+ + + + P+ PP E ++ I +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-RIEF 1286
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
P I ++ +E+ E IS+ T I ++ + + AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILE-DGTLLVIASVTPYDNGEYICVAVNE-- 1343
Query: 1461 ISDASETTEYYKVIKETKIQSPTV---EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
A T Y + K+ P V ++ + N++ N+ L C G P P + WY+
Sbjct: 1344 ---AGTTERKYNL----KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Query: 1518 DGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
D ++ + T N Y C A N G + + + P I
Sbjct: 1397 DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
+N + + + + ++G P P++ W+K+G L + N+ ++ V+ +K
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
+R+ +Y SN AG + ++ L +Y PS G V
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553
Score = 121 bits (291), Expect = 3e-26
Identities = 205/965 (21%), Positives = 343/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 3618 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 3674
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 3675 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 3727
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 3728 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 3787
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 3788 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 3898
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 3899 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 4018 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 4074
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 4075 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 4131
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 4132 S---LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 4185
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 4242
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 4243 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 4302
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P +
Sbjct: 4303 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP-------VF 4351
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ D S W EP G + I+ V+ T +W + I+ L S
Sbjct: 4352 KGDYPS---NWIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS--- 4403
Query: 1451 FRAYAVNEVDISD-ASETTEYYKVIKET---KIQSPTV--EKPLKNITTEPNEDIELTCI 1504
Y D D T V++ + +QSP + +P++ + + I L C
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK-IILNCQ 4462
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 4523 PVIVQ 4527
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C GYP+P+I W I S ++M D TL I+ P+DAG + C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD----GTLFIKNAAPKDAGIYGC 681
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+A N+AG + L +EAP
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP 702
Score = 51.6 bits (118), Expect = 3e-05
Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V EC+ P P ITW++ +I S ++ D L I++
Sbjct: 3064 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 3120
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 3179
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 3180 PPTIAWLKNHKRIENSD-SLEVRILS 3204
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 773 VAINEAGRATGKITLDVGSP 792
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 489 NEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
++K ++ V PT + ++ V K +P V +C G P P ITW +
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKP--------VALQCIANGIPNPSITWLKDDQ 1865
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +Q V L I + EDAG +TCVA NAAG +L V P S
Sbjct: 1866 PVNTAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 4313
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF + + V+ P
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Score = 47.2 bits (107), Expect = 6e-04
Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 1658
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC+ G P P +TW + +K + + ++ + + +E+ D G + CVA
Sbjct: 1659 LTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT 1715
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q +
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI 1775
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVS 1798
Score = 47.2 bits (107), Expect = 6e-04
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G C+V+G P P I W R+ I+ S + + +L I EDAG +
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVNEDAGDY 4417
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA N AG + L +++P
Sbjct: 4418 TCVATNEAGVVERSMSLTLQSP 4439
Score = 45.6 bits (103), Expect = 0.002
Identities = 38/185 (20%), Positives = 69/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ V +++ PV + +G ++ ++G P
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFK-GDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 4379 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 1662 VYDKP 1666
+ P
Sbjct: 4436 LQSPP 4440
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 4239 CVANNAAGEDTHTVSLTV 4256
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 4044
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 4454 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 4509
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 4510 VARNLMGSVLVRVPVIVQ 4527
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 3910 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 3962
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 3963 GRYTCVARNAAGSAHRHVTLHVHEP 3987
>AL133553-2|CAI17858.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-174L6 on chromosome 1. ).
Length = 5635
Score = 235 bits (574), Expect = 2e-60
Identities = 291/1201 (24%), Positives = 482/1201 (40%), Gaps = 129/1201 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ EC+V+G P P +TW + + ++ ++ D+ ++ L ++ + D G + C
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHI--LQLKNIHVSDTGRYVC 2363
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA N AG +L V AP S G+ + P S
Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRS--------------------PENIS------ 2397
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V E + + L C IP P I W FK V N SV I S M L++
Sbjct: 2398 -VVEKNSVSLTCEASGIPLPSITW-FKDGWPVSLSN-SVRILSGGRM----LRLMQTTME 2450
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGN 761
G YT V N GE L + PP ++ L+ + V++ +SV L+ +V GN
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLV----PPHIVGENTLEDVKVKEKQSVTLTCEVTGN 2506
Query: 762 PRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P ITW K+ +P+ +A S G IT + +V G YT A + G S
Sbjct: 2507 PVPEITWHKDGQPLQEDEAHHIISGGRFLQITNV---QVPHTGRYTCLASSPAGHKSRSF 2563
Query: 819 VITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+ V PT +++TV LV P +ITW+++ + +
Sbjct: 2564 SLNVFVSPTIAGVGSD---GNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2620
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL--- 934
I G ++++ D ++G Y CVA+N AG+ V + + + L
Sbjct: 2621 NIRILPGGRTLQILNAQED---NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGP 2677
Query: 935 ---QKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
K + + T+ LEC+ + S WY + + + DH I G
Sbjct: 2678 GLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2735
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIRKLQDF--------EVKEKDVAI---- 1035
D G C+ + E V +P +KL + + KDV I
Sbjct: 2736 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 1036 -LEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L E N + + W +DG + +K G R L I V D G Y+C+ +
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPL-TSSDKVLILPGG--RVLQIPRAKVEDAGRYTCVAVN 2852
Query: 1094 ES--CTAEVTVVELPPEII----TRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSE 1145
E+ + + V L P II + L + NK+ L+ G R W KDG
Sbjct: 2853 EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2912
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
+ +H + +G+ L+I + + D G Y C G++K L V P +
Sbjct: 2913 LLEDDHHKFLSNGR--ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970
Query: 1202 LPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E + V N LT E+ D++W K + I+ ++ RTL I +
Sbjct: 2971 -SENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG--GRTLQIIRAKV 3027
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE----YRIKRGSDVTLLVDYQAFP 1315
D EYTC+ ++ +K K + V PP I D++ E ++ G+ V+L + A P
Sbjct: 3028 SDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W N ++I + H + D + L IKK E +D G Y R N G D ++
Sbjct: 3088 PPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145
Query: 1376 TILDKPS--PPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+ PS P + I+E S+ + + D TG I ++ ++ I+ ++ + V+
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDA---TGIPPPTIAWLKNHKRIENSDSLEVRI 3202
Query: 1433 IT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
++ ++ I + + S + A N + +YY + + E P ++
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNM-----EGKAQKYYFLSIQVPPSVAGAEIP-SDV 3256
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXXXXXXXX 1547
+ E++EL C G+P P + W +DGK + + + N
Sbjct: 3257 SVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3316
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIW 1606
Y C+A N GE + + + P I + ++ ++ + D + + G PPP++ W
Sbjct: 3317 YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW 3376
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
KNG L + + VIRI + S + YT ASN AG + L+V+ P
Sbjct: 3377 LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPP 3434
Query: 1667 S 1667
+
Sbjct: 3435 N 3435
Score = 215 bits (525), Expect = 1e-54
Identities = 273/1202 (22%), Positives = 469/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 1027
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 1082
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 1083 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 1125
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA N G + + L + PP++
Sbjct: 1126 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV----PPKIQR 1175
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 800 EGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+E PT E+ EPP + FQE ++ A+ T
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 1293
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + + LVI +V + D+G+Y CVA N AG +
Sbjct: 1294 -PKPTIKWLHNGRELTGREPGISILEDGTL-LVIASV-TPYDNGEYICVAVNEAGTTERK 1350
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 1351 YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTM-----LVVKETIPEFIRKLQDFEVKE 1030
G+ D G C + TS ++V TI + V
Sbjct: 1411 NNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN 1468
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ + D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 1469 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 1525
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 1586 QPIMSSSQ-ALYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 1638
Query: 1204 EFI----LVPANTDAY----LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + + + KK
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK-- 1696
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLV 1309
L I E D+ +Y CV ++K EV V PP I D + + + + L
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + ++I + K ++ + + +V NT G+Y+ N G
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 1814
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 1815 KKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQ--- 1871
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 1872 -GNL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 1926
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR-XXXXXXXXXXXXX 1545
N T + ++L C G P P +TWY+D + L + T+ NR
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDA 1986
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLT 2044
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 2045 WLKDGSPVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 1666 PS 1667
P+
Sbjct: 2104 PN 2105
Score = 209 bits (511), Expect = 7e-53
Identities = 270/1179 (22%), Positives = 456/1179 (38%), Gaps = 93/1179 (7%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 1233
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 1234 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTVE------------DLEPPYNTT 1274
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F ++ Q ++ C P+P I WL G E+ E ++I D ++L
Sbjct: 1275 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREP-GISILEDG----TLL 1323
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVI 753
I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVTNVSVLLNQLTN 1379
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439
Query: 814 AETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
++ I V P P + F E++V + L +V P P I W+++ +
Sbjct: 1440 SQKYFNIDVLVP------PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 1494 LFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Query: 933 HLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ + LEC+T + WY + + I I +G+
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611
Query: 991 XXDVGVIKCIVKDQETST--MLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-- 1046
D C V + + V +P I + ++ V + + + A
Sbjct: 1612 --DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNP 1669
Query: 1047 ---VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
+ W +DG +K N E G +KL I + D G+Y C+ + E+
Sbjct: 1670 SPILTWLKDGVPVKANDN-IRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYE 1726
Query: 1103 --VELPPEIITRLQNQK--VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
V +PP I + V N + +T + W KDG I + ++ ++
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLN 1786
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVPANTD 1213
G+K L I + + G Y C N+ K +TV P + L E ++V
Sbjct: 1787 GRK--LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
A + +TW K + +T + L R L I K +D YTCV +A
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903
Query: 1274 KSTTKLKVEV-VEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
T+ +++ V PP + D + + + V L P P W +++++
Sbjct: 1904 AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSG 1963
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N++
Sbjct: 1964 S--TSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMV 2021
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ ++ E ++ + + + V + + ++ + + + + R
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQISDTGR 2080
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 2081 YTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Query: 1511 PKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
P +TW +DG L K + ENR Y C A N G+ E + V I
Sbjct: 2133 PTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW 2192
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I S+E + G+ + GIPPP +IW K G+ + D +
Sbjct: 2193 VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR 2252
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++I ++S ++ Y+ ASN AGT+ E L+VY +P+
Sbjct: 2253 QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPT 2291
Score = 200 bits (488), Expect = 4e-50
Identities = 249/1088 (22%), Positives = 430/1088 (39%), Gaps = 92/1088 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+ S V + + LEC IP P + WL G + N +
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+L +T+ + G YT VAVN GE I L++ PP ++ +++ V ++
Sbjct: 2067 --ILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV----PPNIMGEEQNVSVLISQA 2120
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
V L Q P PT+TW K+ P+ P S + S+ ++ +V+D G YT +A N
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YRNN 870
G E + + + P L ++TV E I L+ + P P++ W + +
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIWKKKGS 2235
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKV 928
+++ S + G +L I ++ + D+ Y CVASN AG K + +V I
Sbjct: 2236 PVLTDSMGRVRILSGGR-QLQI-SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTIT 2293
Query: 929 TFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
H + T GK++ LEC+ + W + + EI+ EG
Sbjct: 2294 NSGSHPTEIIVT-RGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQL 2350
Query: 987 XXXXXXDVGVIKCI------VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + D++ + +I R ++ V EK+ L E
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 1041 NS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ESC 1096
+ + W +DG + N G R L + T++ D G+Y+C++R+ E
Sbjct: 2411 SGIPLPSITWFKDGWPVS-LSNSVRILSGG--RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467
Query: 1097 TAEVTVVELPPEII--TRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQ 1153
V +PP I+ L++ KV + T E+T + W KDG +Q
Sbjct: 2468 KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHH 2527
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSIN--FTLRLPEFI 1206
+ G+ L+I + + G Y+C + S+ ++ P+I + PE +
Sbjct: 2528 IISGGR--FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV 2585
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V N+ L E +TW+K + +E ++ RTL I ED+
Sbjct: 2586 TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG--GRTLQILNAQEDNAGR 2643
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVD---------YEREYRIKRGSDVTLLVDYQAFPQ 1316
Y+CV + EV + P I++ +E +IK + +TL + A P
Sbjct: 2644 YSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPS 2703
Query: 1317 PNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+ W + + +K H +I + +L IK+ + +D G Y N G +++ +V
Sbjct: 2704 ASLSWYKDGQPLKSDDHV--NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVN 2761
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENT--GNSTIIYYVVEYQEIDTTEWISVKN-I 1433
I PP + EI + E ++ N +Y T W + +
Sbjct: 2762 I---QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 1434 TKTQ----------TSIQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQSP 1482
T + I K + R+ AVNE ++ +Y +V+ I+
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA----GEDSLQYDVRVLVPPIIKGA 2874
Query: 1483 TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXX 1540
+ P + +T N+ + C+ G P P+ +W +DG+ L N
Sbjct: 2875 NSDLP-EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQKP-VITISNEDIKQKHKVGDEWLVTAVIEGI 1599
Y C+A N G + + + P VI +E++ V + +T + G
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV--VVNNFISLTCEVSGF 2991
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
PPP++ W KN ++ + I +T ++I K S +YT A N AG S + +
Sbjct: 2992 PPPDLSWLKNEQPIKLNTNTLIVPGGRT--LQIIRAKVSDGGEYTCIAINQAGESKKKFS 3049
Query: 1660 LKVYDKPS 1667
L VY PS
Sbjct: 3050 LTVYVPPS 3057
Score = 197 bits (481), Expect = 3e-49
Identities = 269/1219 (22%), Positives = 480/1219 (39%), Gaps = 120/1219 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S ++ EC+ G P P ITW++ I S +Y D + +V D+ T+TC
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQ-ALYIDKGQYLHIPRAQV--SDSATYTCH 1619
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
N AG A + + V P ++EG T P +
Sbjct: 1620 VANVAGTAEKSFHVDVYVP-----------------------PMIEGNLAT----PLNKQ 1652
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + LEC+ P P + WL G + ++NI + L+I + ++
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK------LEIMSAQEID 1706
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGNP 762
G Y VA + GE + K + PP + + IV + L V G+P
Sbjct: 1707 RGQYICVATSVAGEKEI----KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 763 RPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
PTI W K+ + + ++ +V + G+Y A N+ G + +TV
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE-TITQ 881
P P + + E V + + L P PSITW ++++ ++ ++ +
Sbjct: 1823 HVP------PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-ET 940
G +++ T ++ D+G Y CVA+N+AG++ + + V + ++ K ET
Sbjct: 1877 QSSGRVLQIAKTLLE---DAGRYTCVATNAAGETQQ--HIQLHVHEPPSLEDAGKMLNET 1931
Query: 941 E-EGKTVILECQTS-HTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
V LEC+ + + V WY + + +SG + G+ D G+
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS--DAGIY 1989
Query: 998 KCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDG 1053
KC+ + +T L + P V + LE E A + W +DG
Sbjct: 1990 KCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ N G I L + + + D G Y+C+ + + + + V +PP I+
Sbjct: 2050 SPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107
Query: 1111 TRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
QN V L + DA+ + W KDG + L+I + LKI
Sbjct: 2108 GEEQNVSVLISQAVEL---LCQSDAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKIE 2162
Query: 1167 DCDLDDAGEYSCEVGN--SKCTAILTVE---EPSINFTLRLPEFILVPANTDAYLTVEIP 1221
D + D G Y+CE N K V P+I + L + ++ N + L
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSG 2222
Query: 1222 DETLDVTWYKKKS-VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
++ W KK S V+ D+ + ++S R L I + D Y+CV + T K
Sbjct: 2223 IPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 1280 KVEV-VEFPPKIVD---YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ + V P I + + E + RG ++L + Q P P W+ + + K K +
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE 2340
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK----PNILE 1391
I + L +K + +D G Y N G D + ++++ PS G NI
Sbjct: 2341 --ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISV 2398
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRF 1451
++ +S+++ E +I ++ + +S+ N + + + L+ +
Sbjct: 2399 VEKNSVSLTC-EASGIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTME 2450
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVP 1509
A V + A E K+ + + P + E L+++ + + + LTC G P
Sbjct: 2451 DAGQYTCVVRNAAGEER---KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP 2507
Query: 1510 QPKVTWYRDGKKLKTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
P++TW++DG+ L+ +A + Y C+A + G S + +
Sbjct: 2508 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Query: 1568 QQKPVIT-ISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTK 1624
P I + ++ + V + V E PP + W+K+G LE+++ I
Sbjct: 2568 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2627
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+T ++I + ++ +Y+ A+N AG +KVY P +G + +S + V
Sbjct: 2628 GRT--LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVK 2685
Query: 1685 IEWKPPLDDGGLELTKYAI 1703
I+ L LE YAI
Sbjct: 2686 IKVNNTLT---LECEAYAI 2701
Score = 196 bits (477), Expect = 9e-49
Identities = 270/1212 (22%), Positives = 474/1212 (39%), Gaps = 118/1212 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 890
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 891 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 944
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 945 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 993
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P ++ G Y
Sbjct: 994 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYV 1050
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P + L ++ EI+V + L V P P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 1167
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXX 983
V ++ K + + G+ V + C T +K + + E
Sbjct: 1168 HVPPK--IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225
Query: 984 XXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILE 1037
D G+ C+ + ET L V+E P + L+ ++ VA
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQR 1283
Query: 1038 VEI-----NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
+E + + W +G + ++ + G + L I + + +D GEY C+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAV 1341
Query: 1093 DESCTAEVTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSE 1145
+E+ T E V +PP I + Q V N+ E+E T ++ W+KD +
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQ 1400
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLR 1201
+ S+ IQ +GK LK++ +DAG YSC+ G S+ + V P
Sbjct: 1401 VTESSTIQTVNNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 1202 LPEFILVPANTDAYLTVEIPDETL-DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P + V N D L ++ D+ W+K K + L+ + + L ++
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD--RGQVLHLKNAR 1516
Query: 1260 EDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFP 1315
+D+ Y C + +A K +K+ + PP I + + + S + L + + P
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKL-TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLP 1575
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W + + I ID K L I + + +D+ Y + N G A+ +V
Sbjct: 1576 MPAITWYKDGQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVK 1431
+ P G N+ + + I E + GN S I+ ++ + + +
Sbjct: 1634 DVYVPPMIEG--NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAND----- 1686
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLK 1489
NI + + + L+ S+ V S A E Y+V + P +E
Sbjct: 1687 NI-RIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETS 1742
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXX 1547
N +EL C G P P + W +DG+ + + N
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGL 1802
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C+A N G+ + V + P I S +E + K+K + + GIP P +
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSIT 1859
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+ + N + N+ + V++I + + +YT A+N AG + + L V++
Sbjct: 1860 WLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Query: 1666 PSKPEGPVIMRE 1677
PS + ++ E
Sbjct: 1919 PSLEDAGKMLNE 1930
Score = 193 bits (470), Expect = 7e-48
Identities = 242/1089 (22%), Positives = 423/1089 (38%), Gaps = 92/1089 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C + P I W G + + NI + L+I N ++ G Y+ VA
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGG------RTLQILNAQEDNAGRYSCVA 2648
Query: 713 VNREGEASLPIVLK------IKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
N GE +K I G+ P + P K + ++ ++ L + P ++
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPG-LSP-KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 767 TWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+W K+ +P+K+ + H++ I K ++ D G YT A N G E + ++ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQI-KEAQISDTGRYTCVASNIAGEDELDFDVNIQVP 2765
Query: 826 T--EENAEPPLFINRFQEITVKE---KGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
++ E ++ + K+ I L P P++TWY++ ++ S+ +
Sbjct: 2766 PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVL 2825
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS--HGARVTIDVEKVTFVKHLQKSY 938
G +++ V+ D+G Y CVA N AG+ S + RV + L +
Sbjct: 2826 ILPGGRVLQIPRAKVE---DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEV 2882
Query: 939 ETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
K+ ++EC +S + + + W + + + DH + + GR D+G
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGR 2940
Query: 997 IKCIVKDQETSTMLVVKETI---PEFIR-KLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
C+ ++ S + P I K ++ V + L E++ D+ W +
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPE 1108
+ + IK N G R L I V D GEY+CI +++ ++ V +PP
Sbjct: 3001 NEQPIKLNTNTL-IVPGG--RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 1109 IITR----LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
I L V +G + E E ++ W+K+G I S H+++ DG Q L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QML 3115
Query: 1164 KIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I ++ D G+Y C N K + PSI R E I+ + LT
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTC 3173
Query: 1219 E---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ IP T + W K IE+++ + L I + D YTC+ + +
Sbjct: 3174 DATGIPPPT--IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Query: 1276 TT-KLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
K ++ PP + E + + G +V L+ + P P +W+ + K I +
Sbjct: 3232 KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN---- 1388
+ + + ++L I +D G Y N G D N+ + P+ G +
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
++ + +SINI E TG W+ + I+ L
Sbjct: 3352 LMTLVDTSINI---ECRATGTPP-----------PQINWLKNGLPLPLSSHIRLLAAGQV 3397
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTC 1503
R V++V + + K +Q P ++ + + IT + C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 1504 IFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVET 1561
I G P P + W RDG+ L A T Y CIA N+ GEV
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3517
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
++ + + P I S E + V + +T + GIP P++ W K+G L + +
Sbjct: 3518 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--V 3575
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREIS 1679
T V+RI + + +YT AS+ AG E ++V+ P + + P + +
Sbjct: 3576 QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR 3635
Query: 1680 RESVTIEWK 1688
VT+E K
Sbjct: 3636 NRQVTLECK 3644
Score = 184 bits (449), Expect = 2e-45
Identities = 262/1206 (21%), Positives = 456/1206 (37%), Gaps = 135/1206 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G+ + C+ G P P + W ++ + ++ S + I E DA +
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE--KSDAALY 2267
Query: 582 TCVAKNAAGFASS--TTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
+CVA N AG A ++ + +++ GS T ++ +GIPP
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPP----- 2321
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P ++ +G ++ KG EI+ DE +L++ N
Sbjct: 2322 PTVTWMKDGHPLIKA---------------KGVEIL-DEG-------------HILQLKN 2352
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS---MIVRQGESVILSA 756
+ G Y VAVN G L + PP +I +S + V + SV L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHA----PPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ G P P+ITW K+ PV + + L ++D G YT N+ G
Sbjct: 2409 EASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK 2468
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
++V P E N +++ VKEK ++ L VT NPVP ITW+++ + +
Sbjct: 2469 IFGLSVLVPPHIVGE-----NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQED 2523
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E G ++ ITNV +G Y C+AS+ AG S + + V + +
Sbjct: 2524 EAHHIISGGRFLQ--ITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPT--IAGVGS 2578
Query: 937 SYETEEGKTVILECQTS--------HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
E+ TVIL TS + W+ + + + I+ GR
Sbjct: 2579 DGNPED-VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRK-------LQDFEVKEK--DVAILE 1037
+ G C+ ++ E VK IP I K L EVK K + LE
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1038 VEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
E + +A + W +DG+ +K + + GH L I+ + D G Y+C+ + +
Sbjct: 2696 CEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2752
Query: 1097 TAEVTV---VELPPEI--ITRLQNQKVNKGNKATFEIELTKGDAL-----------VRWF 1140
E+ +++PP + + N N ++ + +L + W+
Sbjct: 2753 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI 1196
KDG + S+ + + G+ L+I ++DAG Y+C E G + V P I
Sbjct: 2813 KDGHPLTSSDKVLILPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Query: 1197 --NFTLRLPEFILVPANTDAYL-TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
LPE + V N A + + +W K + + + +S+ R L
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSN--GRIL 2928
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE-YRIKRGSDVTLLVDY 1311
I D Y CV + + K + V PP ++ + E + + ++L +
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
FP P+ W+ N + IK +T I +L I + + +D G Y N G +
Sbjct: 2989 SGFPPPDLSWLKNEQPIK--LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWIS 1429
+ ++T+ PS I + DS S+++ N T + E + W
Sbjct: 3047 KFSLTVYVPPS------IKDHDSESLSVV-----NVREGTSVSLECESNAVPPPVITWYK 3095
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEK 1486
+ T ++ L + V++ + K + P++E
Sbjct: 3096 NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEG 3155
Query: 1487 PLKNITTEP-NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXX 1541
P + + E + + LTC G+P P + W ++ K+++ + +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ 3215
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y CIA N G+ + + IQ P + + +G+ + GIP
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W K+G + + + I S + I S + KYT A+N AG L
Sbjct: 3276 PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 1662 VYDKPS 1667
VY P+
Sbjct: 3336 VYVTPT 3341
Score = 180 bits (439), Expect = 4e-44
Identities = 241/1193 (20%), Positives = 429/1193 (35%), Gaps = 91/1193 (7%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+T+ EC+ P ++W++ +K + N TL I+E D G +TCV
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---NGHTLQIKEAQISDTGRYTCV 2746
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG ++ ++ P S ++L+ + +A+
Sbjct: 2747 ASNIAGEDELDFDVNIQVPPS-------------FQKLWEIGNMLDT-----GRNGEAKD 2788
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + I L C A P P + W G + + + + VL+I K
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG------RVLQIPRAKVED 2842
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G YT VAVN GE SL +++ + + + V +S ++ G+P P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAP 2902
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+W K+ +P+ I + ++ D G Y AEN+ G A+ + V
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV 2962
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P P + + + +TV I L V+ P P ++W +N + I +
Sbjct: 2963 P------PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG 3016
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET---E 941
G ++++ V D G+Y C+A N AG+S +T+ V + H +S
Sbjct: 3017 GRTLQIIRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPP-SIKDHDSESLSVVNVR 3072
Query: 942 EGKTVILECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
EG +V LEC+++ WY N + I+ H EI+ +G+ V +
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 1000 IV---KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
I +D + + V E + E V + + W ++ + I
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRL 1113
+ + + KL I + D G Y+CI + A+ +++PP +
Sbjct: 3193 E-NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 3251
Query: 1114 QNQKVNKGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
V+ E+ L++W KDG I ++ + L IY
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 1171 DDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D G+Y+C N + + P+I E ++ +T +
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 1226 -DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + + L++ + + I + D YTCV + +
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429
Query: 1285 EFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
F P +D E + +GS ++ P P+ W+ + + + H ++ +
Sbjct: 3430 VFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL--TVSTH 3487
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
L + K E D+G Y N G + +L+ P G EI S +N
Sbjct: 3488 GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVIVN--- 3543
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD- 1460
N T I + ++ W+ +Q L R V +
Sbjct: 3544 ----NPLELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGR 3596
Query: 1461 -----ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
S A + + Y V ++P ++IT N + L C VP P +TW
Sbjct: 3597 YTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 1516 YRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
R+G++L+ Y C+A N G+ ++ + P I
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNI 3715
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRI 1632
+ + + ++ + EG+P P + W K+G L N Y+I + + I
Sbjct: 3716 KGGPQSLVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---ENGFLHI 3770
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ + + +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 3823
Score = 178 bits (434), Expect = 2e-43
Identities = 266/1185 (22%), Positives = 444/1185 (37%), Gaps = 112/1185 (9%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
++ +C V G P P I W + +I F++ N LVI + + G + C+A
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL---NGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 587 NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ-YV 645
N AG DH E V +PPT ++ V
Sbjct: 1809 NTAG---------------DHKKEFEVTVH---------------VPPTIKSSGLSERVV 1838
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ + L+C IP P I WL K ++ V ++ I+S VL+I
Sbjct: 1839 VKYKPVALQCIANGIPNPSITWL-KDDQPVNTAQGNLKIQSSGR----VLQIAKTLLEDA 1893
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGESVILSAQVVGNPR 763
G YT VA N GE I L + EPP + + K + V V L + GNP
Sbjct: 1894 GRYTCVATNAAGETQQHIQLHVH----EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPV 1949
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P ITW K+N+ + + + + I ++ ++ D G+Y A NS G E + V
Sbjct: 1950 PVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVH 2009
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
P + V ++L P PS+TW ++ +S Q
Sbjct: 2010 -------VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL 2062
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
G I L +T+ D+G Y CVA N+AG+ + + V + S +
Sbjct: 2063 SGGRI-LALTSAQIS-DTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA 2120
Query: 944 KTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++ + + W + + I E R D G C +
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLS-ISENR-SVLKIEDAQVQDTGRYTCEATN 2178
Query: 1004 --QETSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEINS-ETADVVWERDGE-II 1056
+T V +P I +L V E ++ L E + +++W++ G ++
Sbjct: 2179 VAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRL 1113
+ G R+L I D YSC+ + + TA+ V + P I
Sbjct: 2239 TDSMGRVRILSGG--RQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSG 2296
Query: 1114 QNQK---VNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
+ V +G + E E+ V W KDG + + +++ +G +LK +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLK--NIH 2354
Query: 1170 LDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G Y C N K + PSI R PE I V LT E
Sbjct: 2355 VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIP 2414
Query: 1225 L-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK-STTKLKVE 1282
L +TW+K + + ++S R L + + T +D +YTCV+ +A K+
Sbjct: 2415 LPSITWFKDGWPVSLSNSVRILSG--GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 1283 VVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V PP IV + ++K VTL + P P W + + ++ + I S
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ--EDEAHHIIS 2530
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSS 1395
L I V+ G Y + GH ++ + P+ G P + + +
Sbjct: 2531 GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
S E + +TI ++ + +++ I + +T I N + +++ R+ A
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-KDGTPLESNRNIRILPGGRT-LQILNAQEDNAGRYSCVA 2648
Query: 1456 VNEV-DISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
NE ++ E Y +I + + P + K + + N + L C +P +
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSP--KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 1514 TWYRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+WY+DG+ LK+ N Y C+A N GE E V IQ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 1572 ----VITISNE-DIKQKHKVGDEWLVTAV-----IEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ I N D + + D + + PPP + WYK+G+ L + + I
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLI 2826
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ V++I K + +YT A N AG S++ ++V P
Sbjct: 2827 LPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Score = 176 bits (429), Expect = 6e-43
Identities = 262/1150 (22%), Positives = 439/1150 (38%), Gaps = 122/1150 (10%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLV 658
+ A +SD G T D+ +PP + + V + L C+
Sbjct: 2070 LTSAQISDTG-RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSD 2128
Query: 659 AIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE 718
AIP P + WL G ++ +S++ SVLKI + + G YT A N G+
Sbjct: 2129 AIPPPTLTWLKDGHPLLKKPGLSISENR------SVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 719 ASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
+ I PP + + L + V +G + L + G P P + W K PV
Sbjct: 2183 TEKNYNVNIWV----PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 777 A-----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE-EPTEENA 830
+ S G I+I + D +Y+ A N G A+ + V PT N+
Sbjct: 2239 TDSMGRVRILSGGRQLQISIAEK---SDAALYSCVASNVAGTAKKEYNLQVYIRPTITNS 2295
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
+ EI V +I L V P P++TW ++ + ++ + +G ++L
Sbjct: 2296 G-----SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQL 2350
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQ-KSYETEEGKTVILE 949
+V D+G Y CVA N AG + +++ H ++ E +V L
Sbjct: 2351 KNIHVS---DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 950 CQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--E 1005
C+ S S W+ + +S + I+ GR D G C+V++ E
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNSVRILSGGR--MLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 1006 TSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKN 1061
+ + +P I L+D +VKEK L E+ + ++ W +DG+ ++ +
Sbjct: 2466 ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDE 2524
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELP----------P 1107
+ G R L I N V G Y+C+ +S + + V P P
Sbjct: 2525 AHHIISGG--RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNP 2582
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
E +T + N + +A + A + WFKDG+ ++ + +I++ G+ L+I +
Sbjct: 2583 EDVTVILNSPTSLVCEA-----YSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 1168 CDLDDAGEYSCEVGNSKCTAILTVE-----EPSIN----FTLRL-PEFILVPANTDAYLT 1217
D+AG YSC N I E P IN + L P+ + + N L
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1218 VE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E IP +L +WYK ++ + + ++ TL I++ D YTCV +
Sbjct: 2696 CEAYAIPSASL--SWYKDGQPLKSDDHVNIAAN--GHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 1275 STTKLKVEV-VEFPP---------KIVDYEREYRIKR---GSDVTLLVDYQAFPQPNDEW 1321
+L +V ++ PP ++D R K + ++L + A P P W
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K I L I + + DAG Y N G ++ +V +L P
Sbjct: 2812 YKDGHPL--TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Query: 1382 SPPGKPNILE------IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK 1435
G + L ++ S++ C ++ E D +++S I +
Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQ 2929
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N + R+ A N A +Y+ + + + +N+T
Sbjct: 2930 ----ILNTQITDIGRYVCVAEN-----TAGSAKKYFNL--NVHVPPSVIGPKSENLTVVV 2978
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
N I LTC G P P ++W ++ + KL T Y CIA
Sbjct: 2979 NNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGN 1611
N GE + + + P I + + V + V+ E +PPP + WYKNG
Sbjct: 3039 NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGR 3098
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS--KP 1669
+ I + ++ IK+ + S + +Y A N AG L VY PS P
Sbjct: 3099 MITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGP 3156
Query: 1670 EGPVIMREIS 1679
E VI+ IS
Sbjct: 3157 EREVIVETIS 3166
Score = 173 bits (422), Expect = 4e-42
Identities = 232/1115 (20%), Positives = 425/1115 (38%), Gaps = 83/1115 (7%)
Query: 594 STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL 653
S L +E G E T ++ + PT + EG + L
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTL 1000
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C+ P+P + W KGE ++ + + +D +Y + + + G Y A
Sbjct: 1001 PCKASGNPKPSVIWSKKGE-LISTSSAKFSAGADGSLY-----VVSPGGEESGEYVCTAT 1054
Query: 714 NREGEASLPIVLKIKT-----GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
N G A + L + G++ +P++ ++ GE V L +V P P ITW
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITW 1113
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
K + + + + + D G+Y A N G + + V P +
Sbjct: 1114 AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNFDGEN 887
P + ++ V ++ I A+ T P+P ITW + ++ E N DG
Sbjct: 1174 QRGP-----KHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHHVSNPDGT- 1225
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE-----E 942
L I D+G Y CVA+N AG +T+ V++ V+ L+ Y T
Sbjct: 1226 --LSIDQATPS-DAGIYTCVATNIAGTDE--TEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 943 GKTVILECQTSHTV--STKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ + C T + KW HN +E++G + I+++G D G C
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG--TLLVIASVTPYDNGEYIC 1338
Query: 1000 IVKDQETST--MLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVV-WERDG 1053
+ ++ +T +K +P I+ ++ + V + L E+ + ++ W +D
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ + + G I KL+ + D G YSC + + T++ V +PP II
Sbjct: 1399 VQVT-ESSTIQTVNNGKILKLF--RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 1111 -TRLQNQ-KVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T N+ V E ++ KG + WFKDG + F + + + Q L +
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLK 1513
Query: 1167 DCDLDDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
+ +D G Y C V N+ LT+ P + I V N+ L E
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 1223 ETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ +TWYK I + + I K + L I + D YTC + + T +
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Query: 1282 EVVEFPPKIVDYEREYRIKR----GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V + P +++ + + +TL P P W+ + +K + +
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-- 1689
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
I++ L I + D G Y + G +++ V +L P+ G
Sbjct: 1690 IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 1398 NICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
N+ + TG+ I ++ + Q ID + + + + I + +++ +R A
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N ++ K + T PT++ L + + L CI G+P P +TW
Sbjct: 1809 NTAG--------DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW 1860
Query: 1516 YRDGKKLKTAKATYENRXX---XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+D + + TA+ + + Y C+A N GE + + + + P
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + + + + V + + G P P + WYK+ L ++T + +I I
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGST--SMTFLNRGQIIDI 1978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + S + Y A N+AG + + +L+V+ PS
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 173 bits (421), Expect = 6e-42
Identities = 252/1208 (20%), Positives = 458/1208 (37%), Gaps = 111/1208 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S C+ YP ITWF+ ++ +++ ++ TL I ++AG ++CV
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PGGRTLQILNAQEDNAGRYSCV 2647
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG E+ V P + ++ P S PK
Sbjct: 2648 ATNEAGEMIKHYEVKVYIPPIINKGDLW--------------------GPGLS--PKEVK 2685
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+ + + LEC AIP ++W G+ + D+++++A L+I +
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH------TLQIKEAQISD 2739
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP--QVIEPLKSMIV--RQGES--------V 752
G YT VA N GE L + I+ PP Q + + +M+ R GE+ +
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNIQV----PPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L + P PT+TW K+ P+ + + + KV+D G YT A N G
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Query: 813 IAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ V P N++ P +E+TV + + + +P P +W ++
Sbjct: 2856 EDSLQYDVRVLVPPIIKGANSDLP------EEVTVLVNKSALIECLSSGSPAPRNSWQKD 2909
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + + +G ++++ T + D G Y CVA N+AG + + + V +
Sbjct: 2910 GQPLLEDDHHKFLSNGRILQILNTQIT---DIGRYVCVAENTAGSAKKYFNLNVHVPP-S 2965
Query: 930 FVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ ++ + L C+ S W N++ I + I+ GR
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 988 XXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR-----KLQDFEVKEKDVAILEVEI 1040
D G CI +Q E+ + +P I+ L V+E LE E
Sbjct: 3026 KVS--DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES 3083
Query: 1041 NSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N+ V+ W ++G +I + E + L+I+ V D G+Y C + + +
Sbjct: 3084 NAVPPPVITWYKNGRMITESTH---VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Query: 1100 VTV---VELPPEIITRLQNQKVNK-GNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQL 1154
V +PP I + V N T + T + W K+ I+ S+ +++
Sbjct: 3141 KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEV 3200
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPA 1210
I KL+I D+G Y+C N + A L+++ P +P + V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL 3260
Query: 1211 NTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ L T + W K I E + TL I D +YTCV
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--PQPNDEWIVNS 1325
+ + + V P + + ++ D ++ ++ +A P P W+ N
Sbjct: 3321 ATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP- 1384
+ H + + + + I + + +D +Y N G + N+ + P+
Sbjct: 3381 LPLPLSSHIR--LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDN 3438
Query: 1385 --GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
G I + SS ++ S + ++ + Q + ++V +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMV-LQLLK 3495
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYY--KVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+T S ++ A NE A E ++++ KV++ I + + I P +E
Sbjct: 3496 AETEDSGKYTCIASNE-----AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP---LE 3547
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
LTCI G+P PK+TW +DG+ L T Y C+A + G+
Sbjct: 3548 LTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGD 3607
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ +V + P I ++E + + + +PPP + W +NG +L+
Sbjct: 3608 DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR 3667
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
I + + ++I ++ YT ASN AG ++ E L V P+ GP + +
Sbjct: 3668 VRILSGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVIL 3725
Query: 1679 SRESVTIE 1686
+S +E
Sbjct: 3726 LNKSTVLE 3733
Score = 165 bits (402), Expect = 1e-39
Identities = 238/1078 (22%), Positives = 414/1078 (38%), Gaps = 81/1078 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 847
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 906
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 962
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 1015 SKKGELISTSSAKFSAGADG---SLYVVSPGGE-ESGEYVCTATNTAGYAKRKVQLTVYV 1070
Query: 926 EKVTF--VKHLQKSYETE----EGKTVILECQTSHTVS--TKWYHNKKEISGMDHREIIQ 977
F + L + E G+ V L C+ W + IS R
Sbjct: 1071 RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL 1130
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVA 1034
D G+ C+ + + VK + P+ R + +V+
Sbjct: 1131 P--SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ V+ W + G + + G L I + D G Y+C+ +
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATN 1245
Query: 1094 ESCTAEV----------TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ T E TV +L P T Q + N+ + + T ++W +G
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KPTIKWLHNG 1304
Query: 1144 SEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
E+ I + DG L I D GEY C E G ++ L V P +
Sbjct: 1305 RELTGREPGISILEDG--TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIK 1362
Query: 1199 TLRLPEFILVPAN--TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIR 1256
+ V N T+ + VE + + WYK ++ TE T+ + + L +
Sbjct: 1363 DKEQVTNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDN--VQVTESSTIQTVNNGKILKLF 1419
Query: 1257 KCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQA 1313
+ T +D Y+C ++ T++ + V PP I+ ++ E + DV L +
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKG 1479
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P P+ W + K + +D + L +K D G Y+ + N G ++
Sbjct: 1480 TPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+TI PS G +I ++ E E G I + + Q I ++
Sbjct: 1539 KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS--QALY 1596
Query: 1433 ITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
I K Q I + + S + + N ++ +E + + V I+ + PL N
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVAN---VAGTAEKSFHVDVYVPPMIEG-NLATPL-NK 1651
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYK 1549
+ L C G P P +TW +DG +K Y
Sbjct: 1652 QVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYI 1711
Query: 1550 CIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
C+A + GE E V + P I +E V + + + G PPP ++W K+
Sbjct: 1712 CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD 1771
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
G ++ + I + V I + + S++ Y A+NTAG E + V+ P+
Sbjct: 1772 GQLIDERDGFKILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 164 bits (399), Expect = 3e-39
Identities = 241/1072 (22%), Positives = 409/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 3301
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M +
Sbjct: 3302 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD- 3357
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 3358 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 3418 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 3473 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 3524
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3584
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 3585 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3699
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 3757
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 3758 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 3813
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3871
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 3932 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 3989
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 3990 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 4040
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 4159 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 4214
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 4215 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4266
Score = 160 bits (389), Expect = 4e-38
Identities = 222/1029 (21%), Positives = 397/1029 (38%), Gaps = 84/1029 (8%)
Query: 680 ISVAIESDMHMYCSV-LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+++ ++ + SV L I V EG Y +AV+ G + EPP VI
Sbjct: 468 VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS----EPPPVI 523
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKV 797
+ ++ V GE +L+ ++ +TW +N++ V+ A P + + LK K
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF 583
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y + G + S +TV+EP + P + Q T + + ++ T
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP-----KNQSFTGGSE--VSIMCSAT 636
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P I W N+ I S DG L I N + D+G Y C+ASNSAG
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG---TLFIKNAAPK-DAGIYGCLASNSAGTDKQ 692
Query: 918 GARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHRE 974
+ + I+ K+ V Q G ++EC+TS KW+ E+
Sbjct: 693 NSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF-- 747
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+I + D G C+ ++ T + + + P FI++ D ++
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807
Query: 1032 DVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
L + + W R D I + + L+I N D+G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 1090 ILRDE--SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDALV--RWFKD 1142
++ +E TV + P I V +G + T L G+ + RW K+
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-----NSKCTAILTVEEPSIN 1197
+ + + +I + DG L I L D GEY+C N+K T+++ P+I
Sbjct: 928 SAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 1198 FTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLII 1255
++ I +P + + V W KK +I + KF+ +D +L +
Sbjct: 985 HGQQILSTIEGIPVTLPCKAS---GNPKPSVIWSKKGELISTSSAKFSAGAD---GSLYV 1038
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER--------EYRIKRGSDVT 1306
++ EY C + K KV++ V P++ +R E + G +VT
Sbjct: 1039 VSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
L + ++ P P W +++I + S S+ I + +D+G+Y N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKITETRTSDSGMYLCVATNIA 1156
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G+ + + + P P L++ + D P N + + V+ + + +T
Sbjct: 1157 GNVTQAVKLNVHVPPKIQRGPKHLKV---QVGQRVDIPCNAQGTPL--PVITWSKGGSTM 1211
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE- 1485
+ ++ ++ + Y +I+ E TE ++E PTVE
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE-TEITLHVQE----PPTVED 1266
Query: 1486 -KPLKNITTE---PNEDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXX 1538
+P N T + N+ IE C G P+P + W +G++L + + E+
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIA 1326
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N+ G E + + PVI + + + +EG
Sbjct: 1327 SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P ++WYK + ++ + I T ++++ + +Y+ +A N AGTS
Sbjct: 1387 TPSPIIMWYK--DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 1659 TLKVYDKPS 1667
+ V P+
Sbjct: 1445 NIDVLVPPT 1453
Score = 151 bits (367), Expect = 2e-35
Identities = 241/1167 (20%), Positives = 421/1167 (36%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 3506
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 3561
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 3562 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 3592
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 3593 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 3647
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 3648 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 3708 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 3760
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 3761 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 3817
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 3878 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 3937
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 3938 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3994
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4050
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 4106
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S +L I D YTC+ + S+T K
Sbjct: 4107 PPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4162
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 4163 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 4218
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 4219 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 4267
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 4268 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4324
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K I ++ P V K + EP + L C G P P + W
Sbjct: 4325 TYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN 4384
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 4445 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 4499
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 4500 QKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 149 bits (362), Expect = 8e-35
Identities = 233/1097 (21%), Positives = 389/1097 (35%), Gaps = 84/1097 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + PK Q GS++ + C P+P IAW IV + SD
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT--SD----- 663
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N G Y +A N G L+ E P+++ ++V G+
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRY----IEAPKLMVVQSELLVALGDIT 719
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G P P + W K + ++ + ++ + D G YT A N G
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NN 870
A + V PP+FI +++++ + L V P P+I W R N
Sbjct: 780 RATGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I S +++ L I N+ + D G Y C A N GK VT+
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ EG+ + L C + +W N + + + +G
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
+ + V T VV +P Q E L + + +
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPS 1011
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
V+W + GE+I K+ G LY+ + + GEY C + + A+ V V
Sbjct: 1012 VIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 1104 ELPPEII---TRLQNQK-----VNKGNKATFEIEL-TKGDALVRWFKDGSEIQ-FSNHIQ 1153
+ P + L K V G + T E+ + ++ W K+ I FS
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHT 1128
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
G +KI + D+G Y C GN L V P R P+ + V
Sbjct: 1129 FLPSG---SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP--KIQRGPKHLKVQ 1183
Query: 1210 ANTDAYLTVEIPDETLDV-TWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L V TW K S ++ D E D TL I + T D YT
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATPSDAGIYT 1240
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIK-----RGSDVTLLVDYQAFPQPNDEW 1321
CV + T + ++ + V+ PP + D E Y + + P+P +W
Sbjct: 1241 CVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW 1300
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ N + + + SI L I V D G Y N G + + N+ + P
Sbjct: 1301 LHNGRELTG-REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Query: 1382 SPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
K + + + + + E E T + I++Y + TE +++ + +
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQVTESSTIQTVNNGK-- 1414
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNED 1498
I L + Y+ ++I+ S+ +Y+ + + + + N ++ N D
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQ--KYFNI--DVLVPPTIIGTNFPNEVSVVLNRD 1470
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCIAFND 1555
+ L C G P P + W++DGK L E Y+C N
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G+ + I P I N + + G+P P + WYK+G + +
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG---- 1671
+ +K + I + S S+ YT +N AGT+ + VY P EG
Sbjct: 1591 SSQ--ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY-VPPMIEGNLAT 1647
Query: 1672 PVIMREISRESVTIEWK 1688
P+ + + S+T+E K
Sbjct: 1648 PLNKQVVIAHSLTLECK 1664
Score = 147 bits (356), Expect = 4e-34
Identities = 238/1118 (21%), Positives = 422/1118 (37%), Gaps = 93/1118 (8%)
Query: 599 IVEAPLSDHGS-EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
I + LSD G E D+ E PP + P V G +L C +
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
++ + ++ W ++ E + +++ L++ +VK G Y + + G
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-----LELKSVKFNDAGEYHCMVSSEGG 598
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA 777
++ + L + +EPP+V K+ G V + G P+P I W N+ +
Sbjct: 599 SSAASVFLTV----QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 778 LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-AETSAVITVEEPTEENAEPPLFI 836
+ + +K KD G+Y A NS G + S + +E P + L +
Sbjct: 655 -SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLV 713
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
+ITV E + + P P + W++ + + PS + + + L+
Sbjct: 714 -ALGDITVME-------CKTSGIPPPQVKWFKGDLELRPSTFLIID---PLLGLLKIQET 762
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSH 954
++D+GDY CVA N AG+++ ++T+DV E G V L C Q
Sbjct: 763 QDLDAGDYTCVAINEAGRAT--GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Query: 955 TVSTKW--YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETST 1008
+ KW N S I + R D G C ++Q ++ T
Sbjct: 821 EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 1009 MLVVKETIPEFIRKLQDF-EVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDF 1065
+ V + I V E L + + + W ++ ++ +N Y
Sbjct: 881 TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML--LQNPYIT 938
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITRLQNQKVNKGN 1122
+ L+I + D GEY+C+ + + T T VV + P I Q +G
Sbjct: 939 VRSD--GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + V W K G I S+ DG L + +++GEY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTA 1053
Query: 1179 --EVGNSKCTAILTV-EEPSI-----NFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTW 1229
G +K LTV P + + P I V A + L E+ +TW
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 1230 YKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
K+ +I + + T + ++ I + D Y CV + V++ V P
Sbjct: 1114 AKETQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLT 1346
PKI + +++ G V + + Q P P W S ++ +H + + +L+
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEH---HVSNPDGTLS 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSSSINICW 1401
I + +DAGIY N G + E+ + + + P+ PP E ++ I +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-RIEF 1286
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
P I ++ +E+ E IS+ T I ++ + + AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILE-DGTLLVIASVTPYDNGEYICVAVNE-- 1343
Query: 1461 ISDASETTEYYKVIKETKIQSPTV---EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
A T Y + K+ P V ++ + N++ N+ L C G P P + WY+
Sbjct: 1344 ---AGTTERKYNL----KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Query: 1518 DGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
D ++ + T N Y C A N G + + + P I
Sbjct: 1397 DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
+N + + + + ++G P P++ W+K+G L + N+ ++ V+ +K
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
+R+ +Y SN AG + ++ L +Y PS G V
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553
Score = 121 bits (291), Expect = 3e-26
Identities = 205/965 (21%), Positives = 343/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 3618 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 3674
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 3675 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 3727
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 3728 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 3787
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 3788 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 3898
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 3899 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 4018 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 4074
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 4075 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 4131
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 4132 S---LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 4185
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 4242
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 4243 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 4302
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P +
Sbjct: 4303 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP-------VF 4351
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ D S W EP G + I+ V+ T +W + I+ L S
Sbjct: 4352 KGDYPS---NWIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS--- 4403
Query: 1451 FRAYAVNEVDISD-ASETTEYYKVIKET---KIQSPTV--EKPLKNITTEPNEDIELTCI 1504
Y D D T V++ + +QSP + +P++ + + I L C
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK-IILNCQ 4462
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 4523 PVIVQ 4527
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C GYP+P+I W I S ++M D TL I+ P+DAG + C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD----GTLFIKNAAPKDAGIYGC 681
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+A N+AG + L +EAP
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP 702
Score = 51.6 bits (118), Expect = 3e-05
Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V EC+ P P ITW++ +I S ++ D L I++
Sbjct: 3064 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 3120
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 3179
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 3180 PPTIAWLKNHKRIENSD-SLEVRILS 3204
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 773 VAINEAGRATGKITLDVGSP 792
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 489 NEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
++K ++ V PT + ++ V K +P V +C G P P ITW +
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKP--------VALQCIANGIPNPSITWLKDDQ 1865
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +Q V L I + EDAG +TCVA NAAG +L V P S
Sbjct: 1866 PVNTAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 4313
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF + + V+ P
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Score = 47.2 bits (107), Expect = 6e-04
Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 1658
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC+ G P P +TW + +K + + ++ + + +E+ D G + CVA
Sbjct: 1659 LTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT 1715
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q +
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI 1775
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVS 1798
Score = 47.2 bits (107), Expect = 6e-04
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G C+V+G P P I W R+ I+ S + + +L I EDAG +
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVNEDAGDY 4417
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA N AG + L +++P
Sbjct: 4418 TCVATNEAGVVERSMSLTLQSP 4439
Score = 45.6 bits (103), Expect = 0.002
Identities = 38/185 (20%), Positives = 69/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ V +++ PV + +G ++ ++G P
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFK-GDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 4379 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 1662 VYDKP 1666
+ P
Sbjct: 4436 LQSPP 4440
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 4239 CVANNAAGEDTHTVSLTV 4256
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 4044
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 4454 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 4509
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 4510 VARNLMGSVLVRVPVIVQ 4527
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 3910 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 3962
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 3963 GRYTCVARNAAGSAHRHVTLHVHEP 3987
>AL133515-1|CAI17853.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-153O3 on chromosome 1. ).
Length = 5635
Score = 235 bits (574), Expect = 2e-60
Identities = 291/1201 (24%), Positives = 482/1201 (40%), Gaps = 129/1201 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ EC+V+G P P +TW + + ++ ++ D+ ++ L ++ + D G + C
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHI--LQLKNIHVSDTGRYVC 2363
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA N AG +L V AP S G+ + P S
Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRS--------------------PENIS------ 2397
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V E + + L C IP P I W FK V N SV I S M L++
Sbjct: 2398 -VVEKNSVSLTCEASGIPLPSITW-FKDGWPVSLSN-SVRILSGGRM----LRLMQTTME 2450
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGN 761
G YT V N GE L + PP ++ L+ + V++ +SV L+ +V GN
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLV----PPHIVGENTLEDVKVKEKQSVTLTCEVTGN 2506
Query: 762 PRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P ITW K+ +P+ +A S G IT + +V G YT A + G S
Sbjct: 2507 PVPEITWHKDGQPLQEDEAHHIISGGRFLQITNV---QVPHTGRYTCLASSPAGHKSRSF 2563
Query: 819 VITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+ V PT +++TV LV P +ITW+++ + +
Sbjct: 2564 SLNVFVSPTIAGVGSD---GNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2620
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL--- 934
I G ++++ D ++G Y CVA+N AG+ V + + + L
Sbjct: 2621 NIRILPGGRTLQILNAQED---NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGP 2677
Query: 935 ---QKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
K + + T+ LEC+ + S WY + + + DH I G
Sbjct: 2678 GLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2735
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIRKLQDF--------EVKEKDVAI---- 1035
D G C+ + E V +P +KL + + KDV I
Sbjct: 2736 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 1036 -LEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L E N + + W +DG + +K G R L I V D G Y+C+ +
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPL-TSSDKVLILPGG--RVLQIPRAKVEDAGRYTCVAVN 2852
Query: 1094 ES--CTAEVTVVELPPEII----TRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSE 1145
E+ + + V L P II + L + NK+ L+ G R W KDG
Sbjct: 2853 EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2912
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
+ +H + +G+ L+I + + D G Y C G++K L V P +
Sbjct: 2913 LLEDDHHKFLSNGR--ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970
Query: 1202 LPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E + V N LT E+ D++W K + I+ ++ RTL I +
Sbjct: 2971 -SENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG--GRTLQIIRAKV 3027
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE----YRIKRGSDVTLLVDYQAFP 1315
D EYTC+ ++ +K K + V PP I D++ E ++ G+ V+L + A P
Sbjct: 3028 SDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W N ++I + H + D + L IKK E +D G Y R N G D ++
Sbjct: 3088 PPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145
Query: 1376 TILDKPS--PPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+ PS P + I+E S+ + + D TG I ++ ++ I+ ++ + V+
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDA---TGIPPPTIAWLKNHKRIENSDSLEVRI 3202
Query: 1433 IT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
++ ++ I + + S + A N + +YY + + E P ++
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNM-----EGKAQKYYFLSIQVPPSVAGAEIP-SDV 3256
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXXXXXXXX 1547
+ E++EL C G+P P + W +DGK + + + N
Sbjct: 3257 SVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3316
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIW 1606
Y C+A N GE + + + P I + ++ ++ + D + + G PPP++ W
Sbjct: 3317 YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW 3376
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
KNG L + + VIRI + S + YT ASN AG + L+V+ P
Sbjct: 3377 LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPP 3434
Query: 1667 S 1667
+
Sbjct: 3435 N 3435
Score = 215 bits (525), Expect = 1e-54
Identities = 273/1202 (22%), Positives = 469/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 1027
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 1082
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 1083 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 1125
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA N G + + L + PP++
Sbjct: 1126 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV----PPKIQR 1175
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 800 EGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+E PT E+ EPP + FQE ++ A+ T
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 1293
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + + LVI +V + D+G+Y CVA N AG +
Sbjct: 1294 -PKPTIKWLHNGRELTGREPGISILEDGTL-LVIASV-TPYDNGEYICVAVNEAGTTERK 1350
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 1351 YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTM-----LVVKETIPEFIRKLQDFEVKE 1030
G+ D G C + TS ++V TI + V
Sbjct: 1411 NNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN 1468
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ + D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 1469 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 1525
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 1586 QPIMSSSQ-ALYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 1638
Query: 1204 EFI----LVPANTDAY----LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + + + KK
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK-- 1696
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLV 1309
L I E D+ +Y CV ++K EV V PP I D + + + + L
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + ++I + K ++ + + +V NT G+Y+ N G
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 1814
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 1815 KKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQ--- 1871
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 1872 -GNL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 1926
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR-XXXXXXXXXXXXX 1545
N T + ++L C G P P +TWY+D + L + T+ NR
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDA 1986
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLT 2044
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 2045 WLKDGSPVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 1666 PS 1667
P+
Sbjct: 2104 PN 2105
Score = 209 bits (511), Expect = 7e-53
Identities = 270/1179 (22%), Positives = 456/1179 (38%), Gaps = 93/1179 (7%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 1233
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 1234 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTVE------------DLEPPYNTT 1274
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F ++ Q ++ C P+P I WL G E+ E ++I D ++L
Sbjct: 1275 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREP-GISILEDG----TLL 1323
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVI 753
I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVTNVSVLLNQLTN 1379
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439
Query: 814 AETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
++ I V P P + F E++V + L +V P P I W+++ +
Sbjct: 1440 SQKYFNIDVLVP------PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 1494 LFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Query: 933 HLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ + LEC+T + WY + + I I +G+
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611
Query: 991 XXDVGVIKCIVKDQETST--MLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-- 1046
D C V + + V +P I + ++ V + + + A
Sbjct: 1612 --DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNP 1669
Query: 1047 ---VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
+ W +DG +K N E G +KL I + D G+Y C+ + E+
Sbjct: 1670 SPILTWLKDGVPVKANDN-IRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYE 1726
Query: 1103 --VELPPEIITRLQNQK--VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
V +PP I + V N + +T + W KDG I + ++ ++
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLN 1786
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVPANTD 1213
G+K L I + + G Y C N+ K +TV P + L E ++V
Sbjct: 1787 GRK--LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
A + +TW K + +T + L R L I K +D YTCV +A
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903
Query: 1274 KSTTKLKVEV-VEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
T+ +++ V PP + D + + + V L P P W +++++
Sbjct: 1904 AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSG 1963
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N++
Sbjct: 1964 S--TSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMV 2021
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ ++ E ++ + + + V + + ++ + + + + R
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQISDTGR 2080
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 2081 YTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Query: 1511 PKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
P +TW +DG L K + ENR Y C A N G+ E + V I
Sbjct: 2133 PTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW 2192
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I S+E + G+ + GIPPP +IW K G+ + D +
Sbjct: 2193 VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR 2252
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++I ++S ++ Y+ ASN AGT+ E L+VY +P+
Sbjct: 2253 QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPT 2291
Score = 200 bits (488), Expect = 4e-50
Identities = 249/1088 (22%), Positives = 430/1088 (39%), Gaps = 92/1088 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+ S V + + LEC IP P + WL G + N +
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+L +T+ + G YT VAVN GE I L++ PP ++ +++ V ++
Sbjct: 2067 --ILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV----PPNIMGEEQNVSVLISQA 2120
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
V L Q P PT+TW K+ P+ P S + S+ ++ +V+D G YT +A N
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YRNN 870
G E + + + P L ++TV E I L+ + P P++ W + +
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIWKKKGS 2235
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKV 928
+++ S + G +L I ++ + D+ Y CVASN AG K + +V I
Sbjct: 2236 PVLTDSMGRVRILSGGR-QLQI-SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTIT 2293
Query: 929 TFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
H + T GK++ LEC+ + W + + EI+ EG
Sbjct: 2294 NSGSHPTEIIVT-RGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQL 2350
Query: 987 XXXXXXDVGVIKCI------VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + D++ + +I R ++ V EK+ L E
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 1041 NS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ESC 1096
+ + W +DG + N G R L + T++ D G+Y+C++R+ E
Sbjct: 2411 SGIPLPSITWFKDGWPVS-LSNSVRILSGG--RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467
Query: 1097 TAEVTVVELPPEII--TRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQ 1153
V +PP I+ L++ KV + T E+T + W KDG +Q
Sbjct: 2468 KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHH 2527
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSIN--FTLRLPEFI 1206
+ G+ L+I + + G Y+C + S+ ++ P+I + PE +
Sbjct: 2528 IISGGR--FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV 2585
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V N+ L E +TW+K + +E ++ RTL I ED+
Sbjct: 2586 TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG--GRTLQILNAQEDNAGR 2643
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVD---------YEREYRIKRGSDVTLLVDYQAFPQ 1316
Y+CV + EV + P I++ +E +IK + +TL + A P
Sbjct: 2644 YSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPS 2703
Query: 1317 PNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+ W + + +K H +I + +L IK+ + +D G Y N G +++ +V
Sbjct: 2704 ASLSWYKDGQPLKSDDHV--NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVN 2761
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENT--GNSTIIYYVVEYQEIDTTEWISVKN-I 1433
I PP + EI + E ++ N +Y T W + +
Sbjct: 2762 I---QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 1434 TKTQ----------TSIQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQSP 1482
T + I K + R+ AVNE ++ +Y +V+ I+
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA----GEDSLQYDVRVLVPPIIKGA 2874
Query: 1483 TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXX 1540
+ P + +T N+ + C+ G P P+ +W +DG+ L N
Sbjct: 2875 NSDLP-EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQKP-VITISNEDIKQKHKVGDEWLVTAVIEGI 1599
Y C+A N G + + + P VI +E++ V + +T + G
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV--VVNNFISLTCEVSGF 2991
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
PPP++ W KN ++ + I +T ++I K S +YT A N AG S + +
Sbjct: 2992 PPPDLSWLKNEQPIKLNTNTLIVPGGRT--LQIIRAKVSDGGEYTCIAINQAGESKKKFS 3049
Query: 1660 LKVYDKPS 1667
L VY PS
Sbjct: 3050 LTVYVPPS 3057
Score = 197 bits (481), Expect = 3e-49
Identities = 269/1219 (22%), Positives = 480/1219 (39%), Gaps = 120/1219 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S ++ EC+ G P P ITW++ I S +Y D + +V D+ T+TC
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQ-ALYIDKGQYLHIPRAQV--SDSATYTCH 1619
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
N AG A + + V P ++EG T P +
Sbjct: 1620 VANVAGTAEKSFHVDVYVP-----------------------PMIEGNLAT----PLNKQ 1652
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + LEC+ P P + WL G + ++NI + L+I + ++
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK------LEIMSAQEID 1706
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGNP 762
G Y VA + GE + K + PP + + IV + L V G+P
Sbjct: 1707 RGQYICVATSVAGEKEI----KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 763 RPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
PTI W K+ + + ++ +V + G+Y A N+ G + +TV
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE-TITQ 881
P P + + E V + + L P PSITW ++++ ++ ++ +
Sbjct: 1823 HVP------PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-ET 940
G +++ T ++ D+G Y CVA+N+AG++ + + V + ++ K ET
Sbjct: 1877 QSSGRVLQIAKTLLE---DAGRYTCVATNAAGETQQ--HIQLHVHEPPSLEDAGKMLNET 1931
Query: 941 E-EGKTVILECQTS-HTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
V LEC+ + + V WY + + +SG + G+ D G+
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS--DAGIY 1989
Query: 998 KCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDG 1053
KC+ + +T L + P V + LE E A + W +DG
Sbjct: 1990 KCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ N G I L + + + D G Y+C+ + + + + V +PP I+
Sbjct: 2050 SPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107
Query: 1111 TRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
QN V L + DA+ + W KDG + L+I + LKI
Sbjct: 2108 GEEQNVSVLISQAVEL---LCQSDAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKIE 2162
Query: 1167 DCDLDDAGEYSCEVGN--SKCTAILTVE---EPSINFTLRLPEFILVPANTDAYLTVEIP 1221
D + D G Y+CE N K V P+I + L + ++ N + L
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSG 2222
Query: 1222 DETLDVTWYKKKS-VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
++ W KK S V+ D+ + ++S R L I + D Y+CV + T K
Sbjct: 2223 IPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 1280 KVEV-VEFPPKIVD---YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ + V P I + + E + RG ++L + Q P P W+ + + K K +
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE 2340
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK----PNILE 1391
I + L +K + +D G Y N G D + ++++ PS G NI
Sbjct: 2341 --ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISV 2398
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRF 1451
++ +S+++ E +I ++ + +S+ N + + + L+ +
Sbjct: 2399 VEKNSVSLTC-EASGIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTME 2450
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVP 1509
A V + A E K+ + + P + E L+++ + + + LTC G P
Sbjct: 2451 DAGQYTCVVRNAAGEER---KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP 2507
Query: 1510 QPKVTWYRDGKKLKTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
P++TW++DG+ L+ +A + Y C+A + G S + +
Sbjct: 2508 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Query: 1568 QQKPVIT-ISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTK 1624
P I + ++ + V + V E PP + W+K+G LE+++ I
Sbjct: 2568 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2627
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+T ++I + ++ +Y+ A+N AG +KVY P +G + +S + V
Sbjct: 2628 GRT--LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVK 2685
Query: 1685 IEWKPPLDDGGLELTKYAI 1703
I+ L LE YAI
Sbjct: 2686 IKVNNTLT---LECEAYAI 2701
Score = 196 bits (477), Expect = 9e-49
Identities = 270/1212 (22%), Positives = 474/1212 (39%), Gaps = 118/1212 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 890
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 891 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 944
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 945 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 993
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P ++ G Y
Sbjct: 994 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYV 1050
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P + L ++ EI+V + L V P P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 1167
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXX 983
V ++ K + + G+ V + C T +K + + E
Sbjct: 1168 HVPPK--IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225
Query: 984 XXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILE 1037
D G+ C+ + ET L V+E P + L+ ++ VA
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQR 1283
Query: 1038 VEI-----NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
+E + + W +G + ++ + G + L I + + +D GEY C+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAV 1341
Query: 1093 DESCTAEVTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSE 1145
+E+ T E V +PP I + Q V N+ E+E T ++ W+KD +
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQ 1400
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLR 1201
+ S+ IQ +GK LK++ +DAG YSC+ G S+ + V P
Sbjct: 1401 VTESSTIQTVNNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 1202 LPEFILVPANTDAYLTVEIPDETL-DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P + V N D L ++ D+ W+K K + L+ + + L ++
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD--RGQVLHLKNAR 1516
Query: 1260 EDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFP 1315
+D+ Y C + +A K +K+ + PP I + + + S + L + + P
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKL-TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLP 1575
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W + + I ID K L I + + +D+ Y + N G A+ +V
Sbjct: 1576 MPAITWYKDGQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVK 1431
+ P G N+ + + I E + GN S I+ ++ + + +
Sbjct: 1634 DVYVPPMIEG--NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAND----- 1686
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLK 1489
NI + + + L+ S+ V S A E Y+V + P +E
Sbjct: 1687 NI-RIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETS 1742
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXX 1547
N +EL C G P P + W +DG+ + + N
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGL 1802
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C+A N G+ + V + P I S +E + K+K + + GIP P +
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSIT 1859
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+ + N + N+ + V++I + + +YT A+N AG + + L V++
Sbjct: 1860 WLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Query: 1666 PSKPEGPVIMRE 1677
PS + ++ E
Sbjct: 1919 PSLEDAGKMLNE 1930
Score = 193 bits (470), Expect = 7e-48
Identities = 242/1089 (22%), Positives = 423/1089 (38%), Gaps = 92/1089 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C + P I W G + + NI + L+I N ++ G Y+ VA
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGG------RTLQILNAQEDNAGRYSCVA 2648
Query: 713 VNREGEASLPIVLK------IKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
N GE +K I G+ P + P K + ++ ++ L + P ++
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPG-LSP-KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 767 TWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+W K+ +P+K+ + H++ I K ++ D G YT A N G E + ++ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQI-KEAQISDTGRYTCVASNIAGEDELDFDVNIQVP 2765
Query: 826 T--EENAEPPLFINRFQEITVKE---KGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
++ E ++ + K+ I L P P++TWY++ ++ S+ +
Sbjct: 2766 PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVL 2825
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS--HGARVTIDVEKVTFVKHLQKSY 938
G +++ V+ D+G Y CVA N AG+ S + RV + L +
Sbjct: 2826 ILPGGRVLQIPRAKVE---DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEV 2882
Query: 939 ETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
K+ ++EC +S + + + W + + + DH + + GR D+G
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGR 2940
Query: 997 IKCIVKDQETSTMLVVKETI---PEFIR-KLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
C+ ++ S + P I K ++ V + L E++ D+ W +
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPE 1108
+ + IK N G R L I V D GEY+CI +++ ++ V +PP
Sbjct: 3001 NEQPIKLNTNTL-IVPGG--RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 1109 IITR----LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
I L V +G + E E ++ W+K+G I S H+++ DG Q L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QML 3115
Query: 1164 KIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I ++ D G+Y C N K + PSI R E I+ + LT
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTC 3173
Query: 1219 E---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ IP T + W K IE+++ + L I + D YTC+ + +
Sbjct: 3174 DATGIPPPT--IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Query: 1276 TT-KLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
K ++ PP + E + + G +V L+ + P P +W+ + K I +
Sbjct: 3232 KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN---- 1388
+ + + ++L I +D G Y N G D N+ + P+ G +
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
++ + +SINI E TG W+ + I+ L
Sbjct: 3352 LMTLVDTSINI---ECRATGTPP-----------PQINWLKNGLPLPLSSHIRLLAAGQV 3397
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTC 1503
R V++V + + K +Q P ++ + + IT + C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 1504 IFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVET 1561
I G P P + W RDG+ L A T Y CIA N+ GEV
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3517
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
++ + + P I S E + V + +T + GIP P++ W K+G L + +
Sbjct: 3518 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--V 3575
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREIS 1679
T V+RI + + +YT AS+ AG E ++V+ P + + P + +
Sbjct: 3576 QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR 3635
Query: 1680 RESVTIEWK 1688
VT+E K
Sbjct: 3636 NRQVTLECK 3644
Score = 184 bits (449), Expect = 2e-45
Identities = 262/1206 (21%), Positives = 456/1206 (37%), Gaps = 135/1206 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G+ + C+ G P P + W ++ + ++ S + I E DA +
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE--KSDAALY 2267
Query: 582 TCVAKNAAGFASS--TTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
+CVA N AG A ++ + +++ GS T ++ +GIPP
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPP----- 2321
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P ++ +G ++ KG EI+ DE +L++ N
Sbjct: 2322 PTVTWMKDGHPLIKA---------------KGVEIL-DEG-------------HILQLKN 2352
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS---MIVRQGESVILSA 756
+ G Y VAVN G L + PP +I +S + V + SV L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHA----PPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ G P P+ITW K+ PV + + L ++D G YT N+ G
Sbjct: 2409 EASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK 2468
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
++V P E N +++ VKEK ++ L VT NPVP ITW+++ + +
Sbjct: 2469 IFGLSVLVPPHIVGE-----NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQED 2523
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E G ++ ITNV +G Y C+AS+ AG S + + V + +
Sbjct: 2524 EAHHIISGGRFLQ--ITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPT--IAGVGS 2578
Query: 937 SYETEEGKTVILECQTS--------HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
E+ TVIL TS + W+ + + + I+ GR
Sbjct: 2579 DGNPED-VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRK-------LQDFEVKEK--DVAILE 1037
+ G C+ ++ E VK IP I K L EVK K + LE
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1038 VEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
E + +A + W +DG+ +K + + GH L I+ + D G Y+C+ + +
Sbjct: 2696 CEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2752
Query: 1097 TAEVTV---VELPPEI--ITRLQNQKVNKGNKATFEIELTKGDAL-----------VRWF 1140
E+ +++PP + + N N ++ + +L + W+
Sbjct: 2753 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI 1196
KDG + S+ + + G+ L+I ++DAG Y+C E G + V P I
Sbjct: 2813 KDGHPLTSSDKVLILPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Query: 1197 --NFTLRLPEFILVPANTDAYL-TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
LPE + V N A + + +W K + + + +S+ R L
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSN--GRIL 2928
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE-YRIKRGSDVTLLVDY 1311
I D Y CV + + K + V PP ++ + E + + ++L +
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
FP P+ W+ N + IK +T I +L I + + +D G Y N G +
Sbjct: 2989 SGFPPPDLSWLKNEQPIK--LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWIS 1429
+ ++T+ PS I + DS S+++ N T + E + W
Sbjct: 3047 KFSLTVYVPPS------IKDHDSESLSVV-----NVREGTSVSLECESNAVPPPVITWYK 3095
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEK 1486
+ T ++ L + V++ + K + P++E
Sbjct: 3096 NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEG 3155
Query: 1487 PLKNITTEP-NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXX 1541
P + + E + + LTC G+P P + W ++ K+++ + +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ 3215
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y CIA N G+ + + IQ P + + +G+ + GIP
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W K+G + + + I S + I S + KYT A+N AG L
Sbjct: 3276 PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 1662 VYDKPS 1667
VY P+
Sbjct: 3336 VYVTPT 3341
Score = 180 bits (439), Expect = 4e-44
Identities = 241/1193 (20%), Positives = 429/1193 (35%), Gaps = 91/1193 (7%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+T+ EC+ P ++W++ +K + N TL I+E D G +TCV
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---NGHTLQIKEAQISDTGRYTCV 2746
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG ++ ++ P S ++L+ + +A+
Sbjct: 2747 ASNIAGEDELDFDVNIQVPPS-------------FQKLWEIGNMLDT-----GRNGEAKD 2788
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + I L C A P P + W G + + + + VL+I K
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG------RVLQIPRAKVED 2842
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G YT VAVN GE SL +++ + + + V +S ++ G+P P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAP 2902
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+W K+ +P+ I + ++ D G Y AEN+ G A+ + V
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV 2962
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P P + + + +TV I L V+ P P ++W +N + I +
Sbjct: 2963 P------PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG 3016
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET---E 941
G ++++ V D G+Y C+A N AG+S +T+ V + H +S
Sbjct: 3017 GRTLQIIRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPP-SIKDHDSESLSVVNVR 3072
Query: 942 EGKTVILECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
EG +V LEC+++ WY N + I+ H EI+ +G+ V +
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 1000 IV---KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
I +D + + V E + E V + + W ++ + I
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRL 1113
+ + + KL I + D G Y+CI + A+ +++PP +
Sbjct: 3193 E-NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 3251
Query: 1114 QNQKVNKGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
V+ E+ L++W KDG I ++ + L IY
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 1171 DDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D G+Y+C N + + P+I E ++ +T +
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 1226 -DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + + L++ + + I + D YTCV + +
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429
Query: 1285 EFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
F P +D E + +GS ++ P P+ W+ + + + H ++ +
Sbjct: 3430 VFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL--TVSTH 3487
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
L + K E D+G Y N G + +L+ P G EI S +N
Sbjct: 3488 GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVIVN--- 3543
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD- 1460
N T I + ++ W+ +Q L R V +
Sbjct: 3544 ----NPLELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGR 3596
Query: 1461 -----ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
S A + + Y V ++P ++IT N + L C VP P +TW
Sbjct: 3597 YTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 1516 YRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
R+G++L+ Y C+A N G+ ++ + P I
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNI 3715
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRI 1632
+ + + ++ + EG+P P + W K+G L N Y+I + + I
Sbjct: 3716 KGGPQSLVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---ENGFLHI 3770
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ + + +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 3823
Score = 178 bits (434), Expect = 2e-43
Identities = 266/1185 (22%), Positives = 444/1185 (37%), Gaps = 112/1185 (9%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
++ +C V G P P I W + +I F++ N LVI + + G + C+A
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL---NGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 587 NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ-YV 645
N AG DH E V +PPT ++ V
Sbjct: 1809 NTAG---------------DHKKEFEVTVH---------------VPPTIKSSGLSERVV 1838
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ + L+C IP P I WL K ++ V ++ I+S VL+I
Sbjct: 1839 VKYKPVALQCIANGIPNPSITWL-KDDQPVNTAQGNLKIQSSGR----VLQIAKTLLEDA 1893
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGESVILSAQVVGNPR 763
G YT VA N GE I L + EPP + + K + V V L + GNP
Sbjct: 1894 GRYTCVATNAAGETQQHIQLHVH----EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPV 1949
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P ITW K+N+ + + + + I ++ ++ D G+Y A NS G E + V
Sbjct: 1950 PVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVH 2009
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
P + V ++L P PS+TW ++ +S Q
Sbjct: 2010 -------VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL 2062
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
G I L +T+ D+G Y CVA N+AG+ + + V + S +
Sbjct: 2063 SGGRI-LALTSAQIS-DTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA 2120
Query: 944 KTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++ + + W + + I E R D G C +
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLS-ISENR-SVLKIEDAQVQDTGRYTCEATN 2178
Query: 1004 --QETSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEINS-ETADVVWERDGE-II 1056
+T V +P I +L V E ++ L E + +++W++ G ++
Sbjct: 2179 VAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRL 1113
+ G R+L I D YSC+ + + TA+ V + P I
Sbjct: 2239 TDSMGRVRILSGG--RQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSG 2296
Query: 1114 QNQK---VNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
+ V +G + E E+ V W KDG + + +++ +G +LK +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLK--NIH 2354
Query: 1170 LDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G Y C N K + PSI R PE I V LT E
Sbjct: 2355 VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIP 2414
Query: 1225 L-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK-STTKLKVE 1282
L +TW+K + + ++S R L + + T +D +YTCV+ +A K+
Sbjct: 2415 LPSITWFKDGWPVSLSNSVRILSG--GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 1283 VVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V PP IV + ++K VTL + P P W + + ++ + I S
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ--EDEAHHIIS 2530
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSS 1395
L I V+ G Y + GH ++ + P+ G P + + +
Sbjct: 2531 GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
S E + +TI ++ + +++ I + +T I N + +++ R+ A
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-KDGTPLESNRNIRILPGGRT-LQILNAQEDNAGRYSCVA 2648
Query: 1456 VNEV-DISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
NE ++ E Y +I + + P + K + + N + L C +P +
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSP--KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 1514 TWYRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+WY+DG+ LK+ N Y C+A N GE E V IQ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 1572 ----VITISNE-DIKQKHKVGDEWLVTAV-----IEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ I N D + + D + + PPP + WYK+G+ L + + I
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLI 2826
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ V++I K + +YT A N AG S++ ++V P
Sbjct: 2827 LPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Score = 176 bits (429), Expect = 6e-43
Identities = 262/1150 (22%), Positives = 439/1150 (38%), Gaps = 122/1150 (10%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLV 658
+ A +SD G T D+ +PP + + V + L C+
Sbjct: 2070 LTSAQISDTG-RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSD 2128
Query: 659 AIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE 718
AIP P + WL G ++ +S++ SVLKI + + G YT A N G+
Sbjct: 2129 AIPPPTLTWLKDGHPLLKKPGLSISENR------SVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 719 ASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
+ I PP + + L + V +G + L + G P P + W K PV
Sbjct: 2183 TEKNYNVNIWV----PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 777 A-----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE-EPTEENA 830
+ S G I+I + D +Y+ A N G A+ + V PT N+
Sbjct: 2239 TDSMGRVRILSGGRQLQISIAEK---SDAALYSCVASNVAGTAKKEYNLQVYIRPTITNS 2295
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
+ EI V +I L V P P++TW ++ + ++ + +G ++L
Sbjct: 2296 G-----SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQL 2350
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQ-KSYETEEGKTVILE 949
+V D+G Y CVA N AG + +++ H ++ E +V L
Sbjct: 2351 KNIHVS---DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 950 CQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--E 1005
C+ S S W+ + +S + I+ GR D G C+V++ E
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNSVRILSGGR--MLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 1006 TSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKN 1061
+ + +P I L+D +VKEK L E+ + ++ W +DG+ ++ +
Sbjct: 2466 ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDE 2524
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELP----------P 1107
+ G R L I N V G Y+C+ +S + + V P P
Sbjct: 2525 AHHIISGG--RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNP 2582
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
E +T + N + +A + A + WFKDG+ ++ + +I++ G+ L+I +
Sbjct: 2583 EDVTVILNSPTSLVCEA-----YSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 1168 CDLDDAGEYSCEVGNSKCTAILTVE-----EPSIN----FTLRL-PEFILVPANTDAYLT 1217
D+AG YSC N I E P IN + L P+ + + N L
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1218 VE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E IP +L +WYK ++ + + ++ TL I++ D YTCV +
Sbjct: 2696 CEAYAIPSASL--SWYKDGQPLKSDDHVNIAAN--GHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 1275 STTKLKVEV-VEFPP---------KIVDYEREYRIKR---GSDVTLLVDYQAFPQPNDEW 1321
+L +V ++ PP ++D R K + ++L + A P P W
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K I L I + + DAG Y N G ++ +V +L P
Sbjct: 2812 YKDGHPL--TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Query: 1382 SPPGKPNILE------IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK 1435
G + L ++ S++ C ++ E D +++S I +
Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQ 2929
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N + R+ A N A +Y+ + + + +N+T
Sbjct: 2930 ----ILNTQITDIGRYVCVAEN-----TAGSAKKYFNL--NVHVPPSVIGPKSENLTVVV 2978
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
N I LTC G P P ++W ++ + KL T Y CIA
Sbjct: 2979 NNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGN 1611
N GE + + + P I + + V + V+ E +PPP + WYKNG
Sbjct: 3039 NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGR 3098
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS--KP 1669
+ I + ++ IK+ + S + +Y A N AG L VY PS P
Sbjct: 3099 MITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGP 3156
Query: 1670 EGPVIMREIS 1679
E VI+ IS
Sbjct: 3157 EREVIVETIS 3166
Score = 173 bits (422), Expect = 4e-42
Identities = 232/1115 (20%), Positives = 425/1115 (38%), Gaps = 83/1115 (7%)
Query: 594 STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL 653
S L +E G E T ++ + PT + EG + L
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTL 1000
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C+ P+P + W KGE ++ + + +D +Y + + + G Y A
Sbjct: 1001 PCKASGNPKPSVIWSKKGE-LISTSSAKFSAGADGSLY-----VVSPGGEESGEYVCTAT 1054
Query: 714 NREGEASLPIVLKIKT-----GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
N G A + L + G++ +P++ ++ GE V L +V P P ITW
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITW 1113
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
K + + + + + D G+Y A N G + + V P +
Sbjct: 1114 AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNFDGEN 887
P + ++ V ++ I A+ T P+P ITW + ++ E N DG
Sbjct: 1174 QRGP-----KHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHHVSNPDGT- 1225
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE-----E 942
L I D+G Y CVA+N AG +T+ V++ V+ L+ Y T
Sbjct: 1226 --LSIDQATPS-DAGIYTCVATNIAGTDE--TEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 943 GKTVILECQTSHTV--STKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ + C T + KW HN +E++G + I+++G D G C
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG--TLLVIASVTPYDNGEYIC 1338
Query: 1000 IVKDQETST--MLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVV-WERDG 1053
+ ++ +T +K +P I+ ++ + V + L E+ + ++ W +D
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ + + G I KL+ + D G YSC + + T++ V +PP II
Sbjct: 1399 VQVT-ESSTIQTVNNGKILKLF--RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 1111 -TRLQNQ-KVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T N+ V E ++ KG + WFKDG + F + + + Q L +
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLK 1513
Query: 1167 DCDLDDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
+ +D G Y C V N+ LT+ P + I V N+ L E
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 1223 ETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ +TWYK I + + I K + L I + D YTC + + T +
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Query: 1282 EVVEFPPKIVDYEREYRIKR----GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V + P +++ + + +TL P P W+ + +K + +
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-- 1689
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
I++ L I + D G Y + G +++ V +L P+ G
Sbjct: 1690 IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 1398 NICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
N+ + TG+ I ++ + Q ID + + + + I + +++ +R A
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N ++ K + T PT++ L + + L CI G+P P +TW
Sbjct: 1809 NTAG--------DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW 1860
Query: 1516 YRDGKKLKTAKATYENRXX---XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+D + + TA+ + + Y C+A N GE + + + + P
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + + + + V + + G P P + WYK+ L ++T + +I I
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGST--SMTFLNRGQIIDI 1978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + S + Y A N+AG + + +L+V+ PS
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 173 bits (421), Expect = 6e-42
Identities = 252/1208 (20%), Positives = 458/1208 (37%), Gaps = 111/1208 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S C+ YP ITWF+ ++ +++ ++ TL I ++AG ++CV
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PGGRTLQILNAQEDNAGRYSCV 2647
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG E+ V P + ++ P S PK
Sbjct: 2648 ATNEAGEMIKHYEVKVYIPPIINKGDLW--------------------GPGLS--PKEVK 2685
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+ + + LEC AIP ++W G+ + D+++++A L+I +
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH------TLQIKEAQISD 2739
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP--QVIEPLKSMIV--RQGES--------V 752
G YT VA N GE L + I+ PP Q + + +M+ R GE+ +
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNIQV----PPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L + P PT+TW K+ P+ + + + KV+D G YT A N G
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Query: 813 IAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ V P N++ P +E+TV + + + +P P +W ++
Sbjct: 2856 EDSLQYDVRVLVPPIIKGANSDLP------EEVTVLVNKSALIECLSSGSPAPRNSWQKD 2909
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + + +G ++++ T + D G Y CVA N+AG + + + V +
Sbjct: 2910 GQPLLEDDHHKFLSNGRILQILNTQIT---DIGRYVCVAENTAGSAKKYFNLNVHVPP-S 2965
Query: 930 FVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ ++ + L C+ S W N++ I + I+ GR
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 988 XXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR-----KLQDFEVKEKDVAILEVEI 1040
D G CI +Q E+ + +P I+ L V+E LE E
Sbjct: 3026 KVS--DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES 3083
Query: 1041 NSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N+ V+ W ++G +I + E + L+I+ V D G+Y C + + +
Sbjct: 3084 NAVPPPVITWYKNGRMITESTH---VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Query: 1100 VTV---VELPPEIITRLQNQKVNK-GNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQL 1154
V +PP I + V N T + T + W K+ I+ S+ +++
Sbjct: 3141 KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEV 3200
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPA 1210
I KL+I D+G Y+C N + A L+++ P +P + V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL 3260
Query: 1211 NTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ L T + W K I E + TL I D +YTCV
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--PQPNDEWIVNS 1325
+ + + V P + + ++ D ++ ++ +A P P W+ N
Sbjct: 3321 ATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP- 1384
+ H + + + + I + + +D +Y N G + N+ + P+
Sbjct: 3381 LPLPLSSHIR--LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDN 3438
Query: 1385 --GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
G I + SS ++ S + ++ + Q + ++V +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMV-LQLLK 3495
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYY--KVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+T S ++ A NE A E ++++ KV++ I + + I P +E
Sbjct: 3496 AETEDSGKYTCIASNE-----AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP---LE 3547
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
LTCI G+P PK+TW +DG+ L T Y C+A + G+
Sbjct: 3548 LTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGD 3607
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ +V + P I ++E + + + +PPP + W +NG +L+
Sbjct: 3608 DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR 3667
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
I + + ++I ++ YT ASN AG ++ E L V P+ GP + +
Sbjct: 3668 VRILSGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVIL 3725
Query: 1679 SRESVTIE 1686
+S +E
Sbjct: 3726 LNKSTVLE 3733
Score = 165 bits (402), Expect = 1e-39
Identities = 238/1078 (22%), Positives = 414/1078 (38%), Gaps = 81/1078 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 847
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 906
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 962
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 1015 SKKGELISTSSAKFSAGADG---SLYVVSPGGE-ESGEYVCTATNTAGYAKRKVQLTVYV 1070
Query: 926 EKVTF--VKHLQKSYETE----EGKTVILECQTSHTVS--TKWYHNKKEISGMDHREIIQ 977
F + L + E G+ V L C+ W + IS R
Sbjct: 1071 RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL 1130
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVA 1034
D G+ C+ + + VK + P+ R + +V+
Sbjct: 1131 P--SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ V+ W + G + + G L I + D G Y+C+ +
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATN 1245
Query: 1094 ESCTAEV----------TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ T E TV +L P T Q + N+ + + T ++W +G
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KPTIKWLHNG 1304
Query: 1144 SEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
E+ I + DG L I D GEY C E G ++ L V P +
Sbjct: 1305 RELTGREPGISILEDG--TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIK 1362
Query: 1199 TLRLPEFILVPAN--TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIR 1256
+ V N T+ + VE + + WYK ++ TE T+ + + L +
Sbjct: 1363 DKEQVTNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDN--VQVTESSTIQTVNNGKILKLF 1419
Query: 1257 KCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQA 1313
+ T +D Y+C ++ T++ + V PP I+ ++ E + DV L +
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKG 1479
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P P+ W + K + +D + L +K D G Y+ + N G ++
Sbjct: 1480 TPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+TI PS G +I ++ E E G I + + Q I ++
Sbjct: 1539 KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS--QALY 1596
Query: 1433 ITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
I K Q I + + S + + N ++ +E + + V I+ + PL N
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVAN---VAGTAEKSFHVDVYVPPMIEG-NLATPL-NK 1651
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYK 1549
+ L C G P P +TW +DG +K Y
Sbjct: 1652 QVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYI 1711
Query: 1550 CIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
C+A + GE E V + P I +E V + + + G PPP ++W K+
Sbjct: 1712 CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD 1771
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
G ++ + I + V I + + S++ Y A+NTAG E + V+ P+
Sbjct: 1772 GQLIDERDGFKILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 164 bits (399), Expect = 3e-39
Identities = 241/1072 (22%), Positives = 409/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 3301
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M +
Sbjct: 3302 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD- 3357
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 3358 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 3418 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 3473 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 3524
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3584
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 3585 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3699
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 3757
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 3758 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 3813
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3871
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 3932 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 3989
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 3990 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 4040
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 4159 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 4214
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 4215 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4266
Score = 160 bits (389), Expect = 4e-38
Identities = 222/1029 (21%), Positives = 397/1029 (38%), Gaps = 84/1029 (8%)
Query: 680 ISVAIESDMHMYCSV-LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+++ ++ + SV L I V EG Y +AV+ G + EPP VI
Sbjct: 468 VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS----EPPPVI 523
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKV 797
+ ++ V GE +L+ ++ +TW +N++ V+ A P + + LK K
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF 583
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y + G + S +TV+EP + P + Q T + + ++ T
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP-----KNQSFTGGSE--VSIMCSAT 636
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P I W N+ I S DG L I N + D+G Y C+ASNSAG
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG---TLFIKNAAPK-DAGIYGCLASNSAGTDKQ 692
Query: 918 GARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHRE 974
+ + I+ K+ V Q G ++EC+TS KW+ E+
Sbjct: 693 NSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF-- 747
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+I + D G C+ ++ T + + + P FI++ D ++
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807
Query: 1032 DVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
L + + W R D I + + L+I N D+G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 1090 ILRDE--SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDALV--RWFKD 1142
++ +E TV + P I V +G + T L G+ + RW K+
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-----NSKCTAILTVEEPSIN 1197
+ + + +I + DG L I L D GEY+C N+K T+++ P+I
Sbjct: 928 SAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 1198 FTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLII 1255
++ I +P + + V W KK +I + KF+ +D +L +
Sbjct: 985 HGQQILSTIEGIPVTLPCKAS---GNPKPSVIWSKKGELISTSSAKFSAGAD---GSLYV 1038
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER--------EYRIKRGSDVT 1306
++ EY C + K KV++ V P++ +R E + G +VT
Sbjct: 1039 VSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
L + ++ P P W +++I + S S+ I + +D+G+Y N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKITETRTSDSGMYLCVATNIA 1156
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G+ + + + P P L++ + D P N + + V+ + + +T
Sbjct: 1157 GNVTQAVKLNVHVPPKIQRGPKHLKV---QVGQRVDIPCNAQGTPL--PVITWSKGGSTM 1211
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE- 1485
+ ++ ++ + Y +I+ E TE ++E PTVE
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE-TEITLHVQE----PPTVED 1266
Query: 1486 -KPLKNITTE---PNEDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXX 1538
+P N T + N+ IE C G P+P + W +G++L + + E+
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIA 1326
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N+ G E + + PVI + + + +EG
Sbjct: 1327 SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P ++WYK + ++ + I T ++++ + +Y+ +A N AGTS
Sbjct: 1387 TPSPIIMWYK--DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 1659 TLKVYDKPS 1667
+ V P+
Sbjct: 1445 NIDVLVPPT 1453
Score = 151 bits (367), Expect = 2e-35
Identities = 241/1167 (20%), Positives = 421/1167 (36%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 3506
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 3561
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 3562 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 3592
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 3593 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 3647
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 3648 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 3708 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 3760
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 3761 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 3817
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 3878 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 3937
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 3938 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3994
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4050
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 4106
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S +L I D YTC+ + S+T K
Sbjct: 4107 PPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4162
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 4163 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 4218
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 4219 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 4267
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 4268 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4324
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K I ++ P V K + EP + L C G P P + W
Sbjct: 4325 TYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN 4384
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 4445 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 4499
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 4500 QKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 149 bits (362), Expect = 8e-35
Identities = 233/1097 (21%), Positives = 389/1097 (35%), Gaps = 84/1097 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + PK Q GS++ + C P+P IAW IV + SD
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT--SD----- 663
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N G Y +A N G L+ E P+++ ++V G+
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRY----IEAPKLMVVQSELLVALGDIT 719
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G P P + W K + ++ + ++ + D G YT A N G
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NN 870
A + V PP+FI +++++ + L V P P+I W R N
Sbjct: 780 RATGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I S +++ L I N+ + D G Y C A N GK VT+
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ EG+ + L C + +W N + + + +G
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
+ + V T VV +P Q E L + + +
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPS 1011
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
V+W + GE+I K+ G LY+ + + GEY C + + A+ V V
Sbjct: 1012 VIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 1104 ELPPEII---TRLQNQK-----VNKGNKATFEIEL-TKGDALVRWFKDGSEIQ-FSNHIQ 1153
+ P + L K V G + T E+ + ++ W K+ I FS
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHT 1128
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
G +KI + D+G Y C GN L V P R P+ + V
Sbjct: 1129 FLPSG---SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP--KIQRGPKHLKVQ 1183
Query: 1210 ANTDAYLTVEIPDETLDV-TWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L V TW K S ++ D E D TL I + T D YT
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATPSDAGIYT 1240
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIK-----RGSDVTLLVDYQAFPQPNDEW 1321
CV + T + ++ + V+ PP + D E Y + + P+P +W
Sbjct: 1241 CVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW 1300
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ N + + + SI L I V D G Y N G + + N+ + P
Sbjct: 1301 LHNGRELTG-REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Query: 1382 SPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
K + + + + + E E T + I++Y + TE +++ + +
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQVTESSTIQTVNNGK-- 1414
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNED 1498
I L + Y+ ++I+ S+ +Y+ + + + + N ++ N D
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQ--KYFNI--DVLVPPTIIGTNFPNEVSVVLNRD 1470
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCIAFND 1555
+ L C G P P + W++DGK L E Y+C N
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G+ + I P I N + + G+P P + WYK+G + +
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG---- 1671
+ +K + I + S S+ YT +N AGT+ + VY P EG
Sbjct: 1591 SSQ--ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY-VPPMIEGNLAT 1647
Query: 1672 PVIMREISRESVTIEWK 1688
P+ + + S+T+E K
Sbjct: 1648 PLNKQVVIAHSLTLECK 1664
Score = 147 bits (356), Expect = 4e-34
Identities = 238/1118 (21%), Positives = 422/1118 (37%), Gaps = 93/1118 (8%)
Query: 599 IVEAPLSDHGS-EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
I + LSD G E D+ E PP + P V G +L C +
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
++ + ++ W ++ E + +++ L++ +VK G Y + + G
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-----LELKSVKFNDAGEYHCMVSSEGG 598
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA 777
++ + L + +EPP+V K+ G V + G P+P I W N+ +
Sbjct: 599 SSAASVFLTV----QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 778 LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-AETSAVITVEEPTEENAEPPLFI 836
+ + +K KD G+Y A NS G + S + +E P + L +
Sbjct: 655 -SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLV 713
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
+ITV E + + P P + W++ + + PS + + + L+
Sbjct: 714 -ALGDITVME-------CKTSGIPPPQVKWFKGDLELRPSTFLIID---PLLGLLKIQET 762
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSH 954
++D+GDY CVA N AG+++ ++T+DV E G V L C Q
Sbjct: 763 QDLDAGDYTCVAINEAGRAT--GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Query: 955 TVSTKW--YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETST 1008
+ KW N S I + R D G C ++Q ++ T
Sbjct: 821 EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 1009 MLVVKETIPEFIRKLQDF-EVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDF 1065
+ V + I V E L + + + W ++ ++ +N Y
Sbjct: 881 TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML--LQNPYIT 938
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITRLQNQKVNKGN 1122
+ L+I + D GEY+C+ + + T T VV + P I Q +G
Sbjct: 939 VRSD--GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + V W K G I S+ DG L + +++GEY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTA 1053
Query: 1179 --EVGNSKCTAILTV-EEPSI-----NFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTW 1229
G +K LTV P + + P I V A + L E+ +TW
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 1230 YKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
K+ +I + + T + ++ I + D Y CV + V++ V P
Sbjct: 1114 AKETQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLT 1346
PKI + +++ G V + + Q P P W S ++ +H + + +L+
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEH---HVSNPDGTLS 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSSSINICW 1401
I + +DAGIY N G + E+ + + + P+ PP E ++ I +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-RIEF 1286
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
P I ++ +E+ E IS+ T I ++ + + AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILE-DGTLLVIASVTPYDNGEYICVAVNE-- 1343
Query: 1461 ISDASETTEYYKVIKETKIQSPTV---EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
A T Y + K+ P V ++ + N++ N+ L C G P P + WY+
Sbjct: 1344 ---AGTTERKYNL----KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Query: 1518 DGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
D ++ + T N Y C A N G + + + P I
Sbjct: 1397 DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
+N + + + + ++G P P++ W+K+G L + N+ ++ V+ +K
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
+R+ +Y SN AG + ++ L +Y PS G V
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553
Score = 121 bits (291), Expect = 3e-26
Identities = 205/965 (21%), Positives = 343/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 3618 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 3674
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 3675 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 3727
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 3728 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 3787
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 3788 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 3898
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 3899 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 4018 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 4074
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 4075 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 4131
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 4132 S---LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 4185
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 4242
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 4243 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 4302
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P +
Sbjct: 4303 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP-------VF 4351
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ D S W EP G + I+ V+ T +W + I+ L S
Sbjct: 4352 KGDYPS---NWIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS--- 4403
Query: 1451 FRAYAVNEVDISD-ASETTEYYKVIKET---KIQSPTV--EKPLKNITTEPNEDIELTCI 1504
Y D D T V++ + +QSP + +P++ + + I L C
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK-IILNCQ 4462
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 4523 PVIVQ 4527
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C GYP+P+I W I S ++M D TL I+ P+DAG + C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD----GTLFIKNAAPKDAGIYGC 681
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+A N+AG + L +EAP
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP 702
Score = 51.6 bits (118), Expect = 3e-05
Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V EC+ P P ITW++ +I S ++ D L I++
Sbjct: 3064 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 3120
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 3179
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 3180 PPTIAWLKNHKRIENSD-SLEVRILS 3204
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 773 VAINEAGRATGKITLDVGSP 792
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 489 NEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
++K ++ V PT + ++ V K +P V +C G P P ITW +
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKP--------VALQCIANGIPNPSITWLKDDQ 1865
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +Q V L I + EDAG +TCVA NAAG +L V P S
Sbjct: 1866 PVNTAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 4313
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF + + V+ P
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Score = 47.2 bits (107), Expect = 6e-04
Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 1658
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC+ G P P +TW + +K + + ++ + + +E+ D G + CVA
Sbjct: 1659 LTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT 1715
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q +
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI 1775
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVS 1798
Score = 47.2 bits (107), Expect = 6e-04
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G C+V+G P P I W R+ I+ S + + +L I EDAG +
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVNEDAGDY 4417
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA N AG + L +++P
Sbjct: 4418 TCVATNEAGVVERSMSLTLQSP 4439
Score = 45.6 bits (103), Expect = 0.002
Identities = 38/185 (20%), Positives = 69/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ V +++ PV + +G ++ ++G P
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFK-GDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 4379 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 1662 VYDKP 1666
+ P
Sbjct: 4436 LQSPP 4440
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 4239 CVANNAAGEDTHTVSLTV 4256
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 4044
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 4454 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 4509
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 4510 VARNLMGSVLVRVPVIVQ 4527
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 3910 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 3962
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 3963 GRYTCVARNAAGSAHRHVTLHVHEP 3987
>AL121996-1|CAI17844.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-118G19 on chromosome 1q25.1-31.1. ).
Length = 5635
Score = 235 bits (574), Expect = 2e-60
Identities = 291/1201 (24%), Positives = 482/1201 (40%), Gaps = 129/1201 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ EC+V+G P P +TW + + ++ ++ D+ ++ L ++ + D G + C
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHI--LQLKNIHVSDTGRYVC 2363
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA N AG +L V AP S G+ + P S
Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRS--------------------PENIS------ 2397
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V E + + L C IP P I W FK V N SV I S M L++
Sbjct: 2398 -VVEKNSVSLTCEASGIPLPSITW-FKDGWPVSLSN-SVRILSGGRM----LRLMQTTME 2450
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGN 761
G YT V N GE L + PP ++ L+ + V++ +SV L+ +V GN
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLV----PPHIVGENTLEDVKVKEKQSVTLTCEVTGN 2506
Query: 762 PRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P ITW K+ +P+ +A S G IT + +V G YT A + G S
Sbjct: 2507 PVPEITWHKDGQPLQEDEAHHIISGGRFLQITNV---QVPHTGRYTCLASSPAGHKSRSF 2563
Query: 819 VITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+ V PT +++TV LV P +ITW+++ + +
Sbjct: 2564 SLNVFVSPTIAGVGSD---GNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2620
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL--- 934
I G ++++ D ++G Y CVA+N AG+ V + + + L
Sbjct: 2621 NIRILPGGRTLQILNAQED---NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGP 2677
Query: 935 ---QKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
K + + T+ LEC+ + S WY + + + DH I G
Sbjct: 2678 GLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2735
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIRKLQDF--------EVKEKDVAI---- 1035
D G C+ + E V +P +KL + + KDV I
Sbjct: 2736 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 1036 -LEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L E N + + W +DG + +K G R L I V D G Y+C+ +
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPL-TSSDKVLILPGG--RVLQIPRAKVEDAGRYTCVAVN 2852
Query: 1094 ES--CTAEVTVVELPPEII----TRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSE 1145
E+ + + V L P II + L + NK+ L+ G R W KDG
Sbjct: 2853 EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2912
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
+ +H + +G+ L+I + + D G Y C G++K L V P +
Sbjct: 2913 LLEDDHHKFLSNGR--ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970
Query: 1202 LPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E + V N LT E+ D++W K + I+ ++ RTL I +
Sbjct: 2971 -SENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG--GRTLQIIRAKV 3027
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE----YRIKRGSDVTLLVDYQAFP 1315
D EYTC+ ++ +K K + V PP I D++ E ++ G+ V+L + A P
Sbjct: 3028 SDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W N ++I + H + D + L IKK E +D G Y R N G D ++
Sbjct: 3088 PPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145
Query: 1376 TILDKPS--PPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+ PS P + I+E S+ + + D TG I ++ ++ I+ ++ + V+
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDA---TGIPPPTIAWLKNHKRIENSDSLEVRI 3202
Query: 1433 IT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
++ ++ I + + S + A N + +YY + + E P ++
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNM-----EGKAQKYYFLSIQVPPSVAGAEIP-SDV 3256
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXXXXXXXX 1547
+ E++EL C G+P P + W +DGK + + + N
Sbjct: 3257 SVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3316
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIW 1606
Y C+A N GE + + + P I + ++ ++ + D + + G PPP++ W
Sbjct: 3317 YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW 3376
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
KNG L + + VIRI + S + YT ASN AG + L+V+ P
Sbjct: 3377 LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPP 3434
Query: 1667 S 1667
+
Sbjct: 3435 N 3435
Score = 215 bits (525), Expect = 1e-54
Identities = 273/1202 (22%), Positives = 469/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 1027
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 1082
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 1083 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 1125
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA N G + + L + PP++
Sbjct: 1126 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV----PPKIQR 1175
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 800 EGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+E PT E+ EPP + FQE ++ A+ T
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 1293
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + + LVI +V + D+G+Y CVA N AG +
Sbjct: 1294 -PKPTIKWLHNGRELTGREPGISILEDGTL-LVIASV-TPYDNGEYICVAVNEAGTTERK 1350
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 1351 YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTM-----LVVKETIPEFIRKLQDFEVKE 1030
G+ D G C + TS ++V TI + V
Sbjct: 1411 NNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN 1468
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ + D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 1469 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 1525
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 1586 QPIMSSSQ-ALYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 1638
Query: 1204 EFI----LVPANTDAY----LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + + + KK
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK-- 1696
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLV 1309
L I E D+ +Y CV ++K EV V PP I D + + + + L
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + ++I + K ++ + + +V NT G+Y+ N G
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 1814
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 1815 KKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQ--- 1871
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 1872 -GNL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 1926
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR-XXXXXXXXXXXXX 1545
N T + ++L C G P P +TWY+D + L + T+ NR
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDA 1986
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLT 2044
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 2045 WLKDGSPVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 1666 PS 1667
P+
Sbjct: 2104 PN 2105
Score = 209 bits (511), Expect = 7e-53
Identities = 270/1179 (22%), Positives = 456/1179 (38%), Gaps = 93/1179 (7%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 1233
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 1234 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTVE------------DLEPPYNTT 1274
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F ++ Q ++ C P+P I WL G E+ E ++I D ++L
Sbjct: 1275 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREP-GISILEDG----TLL 1323
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVI 753
I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVTNVSVLLNQLTN 1379
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439
Query: 814 AETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
++ I V P P + F E++V + L +V P P I W+++ +
Sbjct: 1440 SQKYFNIDVLVP------PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 1494 LFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Query: 933 HLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ + LEC+T + WY + + I I +G+
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611
Query: 991 XXDVGVIKCIVKDQETST--MLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-- 1046
D C V + + V +P I + ++ V + + + A
Sbjct: 1612 --DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNP 1669
Query: 1047 ---VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
+ W +DG +K N E G +KL I + D G+Y C+ + E+
Sbjct: 1670 SPILTWLKDGVPVKANDN-IRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYE 1726
Query: 1103 --VELPPEIITRLQNQK--VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
V +PP I + V N + +T + W KDG I + ++ ++
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLN 1786
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVPANTD 1213
G+K L I + + G Y C N+ K +TV P + L E ++V
Sbjct: 1787 GRK--LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
A + +TW K + +T + L R L I K +D YTCV +A
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903
Query: 1274 KSTTKLKVEV-VEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
T+ +++ V PP + D + + + V L P P W +++++
Sbjct: 1904 AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSG 1963
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N++
Sbjct: 1964 S--TSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMV 2021
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ ++ E ++ + + + V + + ++ + + + + R
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQISDTGR 2080
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 2081 YTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Query: 1511 PKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
P +TW +DG L K + ENR Y C A N G+ E + V I
Sbjct: 2133 PTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW 2192
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I S+E + G+ + GIPPP +IW K G+ + D +
Sbjct: 2193 VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR 2252
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++I ++S ++ Y+ ASN AGT+ E L+VY +P+
Sbjct: 2253 QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPT 2291
Score = 200 bits (488), Expect = 4e-50
Identities = 249/1088 (22%), Positives = 430/1088 (39%), Gaps = 92/1088 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+ S V + + LEC IP P + WL G + N +
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+L +T+ + G YT VAVN GE I L++ PP ++ +++ V ++
Sbjct: 2067 --ILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV----PPNIMGEEQNVSVLISQA 2120
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
V L Q P PT+TW K+ P+ P S + S+ ++ +V+D G YT +A N
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YRNN 870
G E + + + P L ++TV E I L+ + P P++ W + +
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIWKKKGS 2235
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKV 928
+++ S + G +L I ++ + D+ Y CVASN AG K + +V I
Sbjct: 2236 PVLTDSMGRVRILSGGR-QLQI-SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTIT 2293
Query: 929 TFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
H + T GK++ LEC+ + W + + EI+ EG
Sbjct: 2294 NSGSHPTEIIVT-RGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQL 2350
Query: 987 XXXXXXDVGVIKCI------VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + D++ + +I R ++ V EK+ L E
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 1041 NS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ESC 1096
+ + W +DG + N G R L + T++ D G+Y+C++R+ E
Sbjct: 2411 SGIPLPSITWFKDGWPVS-LSNSVRILSGG--RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467
Query: 1097 TAEVTVVELPPEII--TRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQ 1153
V +PP I+ L++ KV + T E+T + W KDG +Q
Sbjct: 2468 KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHH 2527
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSIN--FTLRLPEFI 1206
+ G+ L+I + + G Y+C + S+ ++ P+I + PE +
Sbjct: 2528 IISGGR--FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV 2585
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V N+ L E +TW+K + +E ++ RTL I ED+
Sbjct: 2586 TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG--GRTLQILNAQEDNAGR 2643
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVD---------YEREYRIKRGSDVTLLVDYQAFPQ 1316
Y+CV + EV + P I++ +E +IK + +TL + A P
Sbjct: 2644 YSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPS 2703
Query: 1317 PNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+ W + + +K H +I + +L IK+ + +D G Y N G +++ +V
Sbjct: 2704 ASLSWYKDGQPLKSDDHV--NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVN 2761
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENT--GNSTIIYYVVEYQEIDTTEWISVKN-I 1433
I PP + EI + E ++ N +Y T W + +
Sbjct: 2762 I---QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 1434 TKTQ----------TSIQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQSP 1482
T + I K + R+ AVNE ++ +Y +V+ I+
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA----GEDSLQYDVRVLVPPIIKGA 2874
Query: 1483 TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXX 1540
+ P + +T N+ + C+ G P P+ +W +DG+ L N
Sbjct: 2875 NSDLP-EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQKP-VITISNEDIKQKHKVGDEWLVTAVIEGI 1599
Y C+A N G + + + P VI +E++ V + +T + G
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV--VVNNFISLTCEVSGF 2991
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
PPP++ W KN ++ + I +T ++I K S +YT A N AG S + +
Sbjct: 2992 PPPDLSWLKNEQPIKLNTNTLIVPGGRT--LQIIRAKVSDGGEYTCIAINQAGESKKKFS 3049
Query: 1660 LKVYDKPS 1667
L VY PS
Sbjct: 3050 LTVYVPPS 3057
Score = 197 bits (481), Expect = 3e-49
Identities = 269/1219 (22%), Positives = 480/1219 (39%), Gaps = 120/1219 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S ++ EC+ G P P ITW++ I S +Y D + +V D+ T+TC
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQ-ALYIDKGQYLHIPRAQV--SDSATYTCH 1619
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
N AG A + + V P ++EG T P +
Sbjct: 1620 VANVAGTAEKSFHVDVYVP-----------------------PMIEGNLAT----PLNKQ 1652
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + LEC+ P P + WL G + ++NI + L+I + ++
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK------LEIMSAQEID 1706
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGNP 762
G Y VA + GE + K + PP + + IV + L V G+P
Sbjct: 1707 RGQYICVATSVAGEKEI----KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 763 RPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
PTI W K+ + + ++ +V + G+Y A N+ G + +TV
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE-TITQ 881
P P + + E V + + L P PSITW ++++ ++ ++ +
Sbjct: 1823 HVP------PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-ET 940
G +++ T ++ D+G Y CVA+N+AG++ + + V + ++ K ET
Sbjct: 1877 QSSGRVLQIAKTLLE---DAGRYTCVATNAAGETQQ--HIQLHVHEPPSLEDAGKMLNET 1931
Query: 941 E-EGKTVILECQTS-HTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
V LEC+ + + V WY + + +SG + G+ D G+
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS--DAGIY 1989
Query: 998 KCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDG 1053
KC+ + +T L + P V + LE E A + W +DG
Sbjct: 1990 KCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ N G I L + + + D G Y+C+ + + + + V +PP I+
Sbjct: 2050 SPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107
Query: 1111 TRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
QN V L + DA+ + W KDG + L+I + LKI
Sbjct: 2108 GEEQNVSVLISQAVEL---LCQSDAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKIE 2162
Query: 1167 DCDLDDAGEYSCEVGN--SKCTAILTVE---EPSINFTLRLPEFILVPANTDAYLTVEIP 1221
D + D G Y+CE N K V P+I + L + ++ N + L
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSG 2222
Query: 1222 DETLDVTWYKKKS-VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
++ W KK S V+ D+ + ++S R L I + D Y+CV + T K
Sbjct: 2223 IPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 1280 KVEV-VEFPPKIVD---YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ + V P I + + E + RG ++L + Q P P W+ + + K K +
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE 2340
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK----PNILE 1391
I + L +K + +D G Y N G D + ++++ PS G NI
Sbjct: 2341 --ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISV 2398
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRF 1451
++ +S+++ E +I ++ + +S+ N + + + L+ +
Sbjct: 2399 VEKNSVSLTC-EASGIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTME 2450
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVP 1509
A V + A E K+ + + P + E L+++ + + + LTC G P
Sbjct: 2451 DAGQYTCVVRNAAGEER---KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP 2507
Query: 1510 QPKVTWYRDGKKLKTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
P++TW++DG+ L+ +A + Y C+A + G S + +
Sbjct: 2508 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Query: 1568 QQKPVIT-ISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTK 1624
P I + ++ + V + V E PP + W+K+G LE+++ I
Sbjct: 2568 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2627
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+T ++I + ++ +Y+ A+N AG +KVY P +G + +S + V
Sbjct: 2628 GRT--LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVK 2685
Query: 1685 IEWKPPLDDGGLELTKYAI 1703
I+ L LE YAI
Sbjct: 2686 IKVNNTLT---LECEAYAI 2701
Score = 196 bits (477), Expect = 9e-49
Identities = 270/1212 (22%), Positives = 474/1212 (39%), Gaps = 118/1212 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 890
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 891 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 944
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 945 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 993
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P ++ G Y
Sbjct: 994 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYV 1050
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P + L ++ EI+V + L V P P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 1167
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXX 983
V ++ K + + G+ V + C T +K + + E
Sbjct: 1168 HVPPK--IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225
Query: 984 XXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILE 1037
D G+ C+ + ET L V+E P + L+ ++ VA
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQR 1283
Query: 1038 VEI-----NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
+E + + W +G + ++ + G + L I + + +D GEY C+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAV 1341
Query: 1093 DESCTAEVTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSE 1145
+E+ T E V +PP I + Q V N+ E+E T ++ W+KD +
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQ 1400
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLR 1201
+ S+ IQ +GK LK++ +DAG YSC+ G S+ + V P
Sbjct: 1401 VTESSTIQTVNNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 1202 LPEFILVPANTDAYLTVEIPDETL-DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P + V N D L ++ D+ W+K K + L+ + + L ++
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD--RGQVLHLKNAR 1516
Query: 1260 EDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFP 1315
+D+ Y C + +A K +K+ + PP I + + + S + L + + P
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKL-TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLP 1575
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W + + I ID K L I + + +D+ Y + N G A+ +V
Sbjct: 1576 MPAITWYKDGQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVK 1431
+ P G N+ + + I E + GN S I+ ++ + + +
Sbjct: 1634 DVYVPPMIEG--NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAND----- 1686
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLK 1489
NI + + + L+ S+ V S A E Y+V + P +E
Sbjct: 1687 NI-RIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETS 1742
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXX 1547
N +EL C G P P + W +DG+ + + N
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGL 1802
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C+A N G+ + V + P I S +E + K+K + + GIP P +
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSIT 1859
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+ + N + N+ + V++I + + +YT A+N AG + + L V++
Sbjct: 1860 WLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Query: 1666 PSKPEGPVIMRE 1677
PS + ++ E
Sbjct: 1919 PSLEDAGKMLNE 1930
Score = 193 bits (470), Expect = 7e-48
Identities = 242/1089 (22%), Positives = 423/1089 (38%), Gaps = 92/1089 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C + P I W G + + NI + L+I N ++ G Y+ VA
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGG------RTLQILNAQEDNAGRYSCVA 2648
Query: 713 VNREGEASLPIVLK------IKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
N GE +K I G+ P + P K + ++ ++ L + P ++
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPG-LSP-KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 767 TWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+W K+ +P+K+ + H++ I K ++ D G YT A N G E + ++ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQI-KEAQISDTGRYTCVASNIAGEDELDFDVNIQVP 2765
Query: 826 T--EENAEPPLFINRFQEITVKE---KGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
++ E ++ + K+ I L P P++TWY++ ++ S+ +
Sbjct: 2766 PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVL 2825
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS--HGARVTIDVEKVTFVKHLQKSY 938
G +++ V+ D+G Y CVA N AG+ S + RV + L +
Sbjct: 2826 ILPGGRVLQIPRAKVE---DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEV 2882
Query: 939 ETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
K+ ++EC +S + + + W + + + DH + + GR D+G
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGR 2940
Query: 997 IKCIVKDQETSTMLVVKETI---PEFIR-KLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
C+ ++ S + P I K ++ V + L E++ D+ W +
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPE 1108
+ + IK N G R L I V D GEY+CI +++ ++ V +PP
Sbjct: 3001 NEQPIKLNTNTL-IVPGG--RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 1109 IITR----LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
I L V +G + E E ++ W+K+G I S H+++ DG Q L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QML 3115
Query: 1164 KIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I ++ D G+Y C N K + PSI R E I+ + LT
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTC 3173
Query: 1219 E---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ IP T + W K IE+++ + L I + D YTC+ + +
Sbjct: 3174 DATGIPPPT--IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Query: 1276 TT-KLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
K ++ PP + E + + G +V L+ + P P +W+ + K I +
Sbjct: 3232 KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN---- 1388
+ + + ++L I +D G Y N G D N+ + P+ G +
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
++ + +SINI E TG W+ + I+ L
Sbjct: 3352 LMTLVDTSINI---ECRATGTPP-----------PQINWLKNGLPLPLSSHIRLLAAGQV 3397
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTC 1503
R V++V + + K +Q P ++ + + IT + C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 1504 IFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVET 1561
I G P P + W RDG+ L A T Y CIA N+ GEV
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3517
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
++ + + P I S E + V + +T + GIP P++ W K+G L + +
Sbjct: 3518 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--V 3575
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREIS 1679
T V+RI + + +YT AS+ AG E ++V+ P + + P + +
Sbjct: 3576 QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR 3635
Query: 1680 RESVTIEWK 1688
VT+E K
Sbjct: 3636 NRQVTLECK 3644
Score = 184 bits (449), Expect = 2e-45
Identities = 262/1206 (21%), Positives = 456/1206 (37%), Gaps = 135/1206 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G+ + C+ G P P + W ++ + ++ S + I E DA +
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE--KSDAALY 2267
Query: 582 TCVAKNAAGFASS--TTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
+CVA N AG A ++ + +++ GS T ++ +GIPP
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPP----- 2321
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P ++ +G ++ KG EI+ DE +L++ N
Sbjct: 2322 PTVTWMKDGHPLIKA---------------KGVEIL-DEG-------------HILQLKN 2352
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS---MIVRQGESVILSA 756
+ G Y VAVN G L + PP +I +S + V + SV L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHA----PPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ G P P+ITW K+ PV + + L ++D G YT N+ G
Sbjct: 2409 EASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK 2468
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
++V P E N +++ VKEK ++ L VT NPVP ITW+++ + +
Sbjct: 2469 IFGLSVLVPPHIVGE-----NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQED 2523
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E G ++ ITNV +G Y C+AS+ AG S + + V + +
Sbjct: 2524 EAHHIISGGRFLQ--ITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPT--IAGVGS 2578
Query: 937 SYETEEGKTVILECQTS--------HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
E+ TVIL TS + W+ + + + I+ GR
Sbjct: 2579 DGNPED-VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRK-------LQDFEVKEK--DVAILE 1037
+ G C+ ++ E VK IP I K L EVK K + LE
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1038 VEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
E + +A + W +DG+ +K + + GH L I+ + D G Y+C+ + +
Sbjct: 2696 CEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2752
Query: 1097 TAEVTV---VELPPEI--ITRLQNQKVNKGNKATFEIELTKGDAL-----------VRWF 1140
E+ +++PP + + N N ++ + +L + W+
Sbjct: 2753 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI 1196
KDG + S+ + + G+ L+I ++DAG Y+C E G + V P I
Sbjct: 2813 KDGHPLTSSDKVLILPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Query: 1197 --NFTLRLPEFILVPANTDAYL-TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
LPE + V N A + + +W K + + + +S+ R L
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSN--GRIL 2928
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE-YRIKRGSDVTLLVDY 1311
I D Y CV + + K + V PP ++ + E + + ++L +
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
FP P+ W+ N + IK +T I +L I + + +D G Y N G +
Sbjct: 2989 SGFPPPDLSWLKNEQPIK--LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWIS 1429
+ ++T+ PS I + DS S+++ N T + E + W
Sbjct: 3047 KFSLTVYVPPS------IKDHDSESLSVV-----NVREGTSVSLECESNAVPPPVITWYK 3095
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEK 1486
+ T ++ L + V++ + K + P++E
Sbjct: 3096 NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEG 3155
Query: 1487 PLKNITTEP-NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXX 1541
P + + E + + LTC G+P P + W ++ K+++ + +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ 3215
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y CIA N G+ + + IQ P + + +G+ + GIP
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W K+G + + + I S + I S + KYT A+N AG L
Sbjct: 3276 PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 1662 VYDKPS 1667
VY P+
Sbjct: 3336 VYVTPT 3341
Score = 180 bits (439), Expect = 4e-44
Identities = 241/1193 (20%), Positives = 429/1193 (35%), Gaps = 91/1193 (7%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+T+ EC+ P ++W++ +K + N TL I+E D G +TCV
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---NGHTLQIKEAQISDTGRYTCV 2746
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG ++ ++ P S ++L+ + +A+
Sbjct: 2747 ASNIAGEDELDFDVNIQVPPS-------------FQKLWEIGNMLDT-----GRNGEAKD 2788
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + I L C A P P + W G + + + + VL+I K
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG------RVLQIPRAKVED 2842
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G YT VAVN GE SL +++ + + + V +S ++ G+P P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAP 2902
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+W K+ +P+ I + ++ D G Y AEN+ G A+ + V
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV 2962
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P P + + + +TV I L V+ P P ++W +N + I +
Sbjct: 2963 P------PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG 3016
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET---E 941
G ++++ V D G+Y C+A N AG+S +T+ V + H +S
Sbjct: 3017 GRTLQIIRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPP-SIKDHDSESLSVVNVR 3072
Query: 942 EGKTVILECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
EG +V LEC+++ WY N + I+ H EI+ +G+ V +
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 1000 IV---KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
I +D + + V E + E V + + W ++ + I
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRL 1113
+ + + KL I + D G Y+CI + A+ +++PP +
Sbjct: 3193 E-NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 3251
Query: 1114 QNQKVNKGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
V+ E+ L++W KDG I ++ + L IY
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 1171 DDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D G+Y+C N + + P+I E ++ +T +
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 1226 -DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + + L++ + + I + D YTCV + +
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429
Query: 1285 EFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
F P +D E + +GS ++ P P+ W+ + + + H ++ +
Sbjct: 3430 VFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL--TVSTH 3487
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
L + K E D+G Y N G + +L+ P G EI S +N
Sbjct: 3488 GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVIVN--- 3543
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD- 1460
N T I + ++ W+ +Q L R V +
Sbjct: 3544 ----NPLELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGR 3596
Query: 1461 -----ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
S A + + Y V ++P ++IT N + L C VP P +TW
Sbjct: 3597 YTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 1516 YRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
R+G++L+ Y C+A N G+ ++ + P I
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNI 3715
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRI 1632
+ + + ++ + EG+P P + W K+G L N Y+I + + I
Sbjct: 3716 KGGPQSLVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---ENGFLHI 3770
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ + + +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 3823
Score = 178 bits (434), Expect = 2e-43
Identities = 266/1185 (22%), Positives = 444/1185 (37%), Gaps = 112/1185 (9%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
++ +C V G P P I W + +I F++ N LVI + + G + C+A
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL---NGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 587 NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ-YV 645
N AG DH E V +PPT ++ V
Sbjct: 1809 NTAG---------------DHKKEFEVTVH---------------VPPTIKSSGLSERVV 1838
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ + L+C IP P I WL K ++ V ++ I+S VL+I
Sbjct: 1839 VKYKPVALQCIANGIPNPSITWL-KDDQPVNTAQGNLKIQSSGR----VLQIAKTLLEDA 1893
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGESVILSAQVVGNPR 763
G YT VA N GE I L + EPP + + K + V V L + GNP
Sbjct: 1894 GRYTCVATNAAGETQQHIQLHVH----EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPV 1949
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P ITW K+N+ + + + + I ++ ++ D G+Y A NS G E + V
Sbjct: 1950 PVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVH 2009
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
P + V ++L P PS+TW ++ +S Q
Sbjct: 2010 -------VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL 2062
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
G I L +T+ D+G Y CVA N+AG+ + + V + S +
Sbjct: 2063 SGGRI-LALTSAQIS-DTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA 2120
Query: 944 KTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++ + + W + + I E R D G C +
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLS-ISENR-SVLKIEDAQVQDTGRYTCEATN 2178
Query: 1004 --QETSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEINS-ETADVVWERDGE-II 1056
+T V +P I +L V E ++ L E + +++W++ G ++
Sbjct: 2179 VAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRL 1113
+ G R+L I D YSC+ + + TA+ V + P I
Sbjct: 2239 TDSMGRVRILSGG--RQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSG 2296
Query: 1114 QNQK---VNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
+ V +G + E E+ V W KDG + + +++ +G +LK +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLK--NIH 2354
Query: 1170 LDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G Y C N K + PSI R PE I V LT E
Sbjct: 2355 VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIP 2414
Query: 1225 L-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK-STTKLKVE 1282
L +TW+K + + ++S R L + + T +D +YTCV+ +A K+
Sbjct: 2415 LPSITWFKDGWPVSLSNSVRILSG--GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 1283 VVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V PP IV + ++K VTL + P P W + + ++ + I S
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ--EDEAHHIIS 2530
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSS 1395
L I V+ G Y + GH ++ + P+ G P + + +
Sbjct: 2531 GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
S E + +TI ++ + +++ I + +T I N + +++ R+ A
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-KDGTPLESNRNIRILPGGRT-LQILNAQEDNAGRYSCVA 2648
Query: 1456 VNEV-DISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
NE ++ E Y +I + + P + K + + N + L C +P +
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSP--KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 1514 TWYRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+WY+DG+ LK+ N Y C+A N GE E V IQ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 1572 ----VITISNE-DIKQKHKVGDEWLVTAV-----IEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ I N D + + D + + PPP + WYK+G+ L + + I
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLI 2826
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ V++I K + +YT A N AG S++ ++V P
Sbjct: 2827 LPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Score = 176 bits (429), Expect = 6e-43
Identities = 262/1150 (22%), Positives = 439/1150 (38%), Gaps = 122/1150 (10%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLV 658
+ A +SD G T D+ +PP + + V + L C+
Sbjct: 2070 LTSAQISDTG-RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSD 2128
Query: 659 AIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE 718
AIP P + WL G ++ +S++ SVLKI + + G YT A N G+
Sbjct: 2129 AIPPPTLTWLKDGHPLLKKPGLSISENR------SVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 719 ASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
+ I PP + + L + V +G + L + G P P + W K PV
Sbjct: 2183 TEKNYNVNIWV----PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 777 A-----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE-EPTEENA 830
+ S G I+I + D +Y+ A N G A+ + V PT N+
Sbjct: 2239 TDSMGRVRILSGGRQLQISIAEK---SDAALYSCVASNVAGTAKKEYNLQVYIRPTITNS 2295
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
+ EI V +I L V P P++TW ++ + ++ + +G ++L
Sbjct: 2296 G-----SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQL 2350
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQ-KSYETEEGKTVILE 949
+V D+G Y CVA N AG + +++ H ++ E +V L
Sbjct: 2351 KNIHVS---DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 950 CQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--E 1005
C+ S S W+ + +S + I+ GR D G C+V++ E
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNSVRILSGGR--MLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 1006 TSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKN 1061
+ + +P I L+D +VKEK L E+ + ++ W +DG+ ++ +
Sbjct: 2466 ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDE 2524
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELP----------P 1107
+ G R L I N V G Y+C+ +S + + V P P
Sbjct: 2525 AHHIISGG--RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNP 2582
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
E +T + N + +A + A + WFKDG+ ++ + +I++ G+ L+I +
Sbjct: 2583 EDVTVILNSPTSLVCEA-----YSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 1168 CDLDDAGEYSCEVGNSKCTAILTVE-----EPSIN----FTLRL-PEFILVPANTDAYLT 1217
D+AG YSC N I E P IN + L P+ + + N L
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1218 VE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E IP +L +WYK ++ + + ++ TL I++ D YTCV +
Sbjct: 2696 CEAYAIPSASL--SWYKDGQPLKSDDHVNIAAN--GHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 1275 STTKLKVEV-VEFPP---------KIVDYEREYRIKR---GSDVTLLVDYQAFPQPNDEW 1321
+L +V ++ PP ++D R K + ++L + A P P W
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K I L I + + DAG Y N G ++ +V +L P
Sbjct: 2812 YKDGHPL--TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Query: 1382 SPPGKPNILE------IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK 1435
G + L ++ S++ C ++ E D +++S I +
Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQ 2929
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N + R+ A N A +Y+ + + + +N+T
Sbjct: 2930 ----ILNTQITDIGRYVCVAEN-----TAGSAKKYFNL--NVHVPPSVIGPKSENLTVVV 2978
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
N I LTC G P P ++W ++ + KL T Y CIA
Sbjct: 2979 NNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGN 1611
N GE + + + P I + + V + V+ E +PPP + WYKNG
Sbjct: 3039 NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGR 3098
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS--KP 1669
+ I + ++ IK+ + S + +Y A N AG L VY PS P
Sbjct: 3099 MITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGP 3156
Query: 1670 EGPVIMREIS 1679
E VI+ IS
Sbjct: 3157 EREVIVETIS 3166
Score = 173 bits (422), Expect = 4e-42
Identities = 232/1115 (20%), Positives = 425/1115 (38%), Gaps = 83/1115 (7%)
Query: 594 STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL 653
S L +E G E T ++ + PT + EG + L
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTL 1000
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C+ P+P + W KGE ++ + + +D +Y + + + G Y A
Sbjct: 1001 PCKASGNPKPSVIWSKKGE-LISTSSAKFSAGADGSLY-----VVSPGGEESGEYVCTAT 1054
Query: 714 NREGEASLPIVLKIKT-----GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
N G A + L + G++ +P++ ++ GE V L +V P P ITW
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITW 1113
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
K + + + + + D G+Y A N G + + V P +
Sbjct: 1114 AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNFDGEN 887
P + ++ V ++ I A+ T P+P ITW + ++ E N DG
Sbjct: 1174 QRGP-----KHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHHVSNPDGT- 1225
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE-----E 942
L I D+G Y CVA+N AG +T+ V++ V+ L+ Y T
Sbjct: 1226 --LSIDQATPS-DAGIYTCVATNIAGTDE--TEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 943 GKTVILECQTSHTV--STKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ + C T + KW HN +E++G + I+++G D G C
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG--TLLVIASVTPYDNGEYIC 1338
Query: 1000 IVKDQETST--MLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVV-WERDG 1053
+ ++ +T +K +P I+ ++ + V + L E+ + ++ W +D
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ + + G I KL+ + D G YSC + + T++ V +PP II
Sbjct: 1399 VQVT-ESSTIQTVNNGKILKLF--RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 1111 -TRLQNQ-KVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T N+ V E ++ KG + WFKDG + F + + + Q L +
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLK 1513
Query: 1167 DCDLDDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
+ +D G Y C V N+ LT+ P + I V N+ L E
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 1223 ETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ +TWYK I + + I K + L I + D YTC + + T +
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Query: 1282 EVVEFPPKIVDYEREYRIKR----GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V + P +++ + + +TL P P W+ + +K + +
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-- 1689
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
I++ L I + D G Y + G +++ V +L P+ G
Sbjct: 1690 IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 1398 NICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
N+ + TG+ I ++ + Q ID + + + + I + +++ +R A
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N ++ K + T PT++ L + + L CI G+P P +TW
Sbjct: 1809 NTAG--------DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW 1860
Query: 1516 YRDGKKLKTAKATYENRXX---XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+D + + TA+ + + Y C+A N GE + + + + P
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + + + + V + + G P P + WYK+ L ++T + +I I
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGST--SMTFLNRGQIIDI 1978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + S + Y A N+AG + + +L+V+ PS
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 173 bits (421), Expect = 6e-42
Identities = 252/1208 (20%), Positives = 458/1208 (37%), Gaps = 111/1208 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S C+ YP ITWF+ ++ +++ ++ TL I ++AG ++CV
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PGGRTLQILNAQEDNAGRYSCV 2647
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG E+ V P + ++ P S PK
Sbjct: 2648 ATNEAGEMIKHYEVKVYIPPIINKGDLW--------------------GPGLS--PKEVK 2685
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+ + + LEC AIP ++W G+ + D+++++A L+I +
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH------TLQIKEAQISD 2739
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP--QVIEPLKSMIV--RQGES--------V 752
G YT VA N GE L + I+ PP Q + + +M+ R GE+ +
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNIQV----PPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L + P PT+TW K+ P+ + + + KV+D G YT A N G
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Query: 813 IAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ V P N++ P +E+TV + + + +P P +W ++
Sbjct: 2856 EDSLQYDVRVLVPPIIKGANSDLP------EEVTVLVNKSALIECLSSGSPAPRNSWQKD 2909
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + + +G ++++ T + D G Y CVA N+AG + + + V +
Sbjct: 2910 GQPLLEDDHHKFLSNGRILQILNTQIT---DIGRYVCVAENTAGSAKKYFNLNVHVPP-S 2965
Query: 930 FVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ ++ + L C+ S W N++ I + I+ GR
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 988 XXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR-----KLQDFEVKEKDVAILEVEI 1040
D G CI +Q E+ + +P I+ L V+E LE E
Sbjct: 3026 KVS--DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES 3083
Query: 1041 NSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N+ V+ W ++G +I + E + L+I+ V D G+Y C + + +
Sbjct: 3084 NAVPPPVITWYKNGRMITESTH---VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Query: 1100 VTV---VELPPEIITRLQNQKVNK-GNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQL 1154
V +PP I + V N T + T + W K+ I+ S+ +++
Sbjct: 3141 KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEV 3200
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPA 1210
I KL+I D+G Y+C N + A L+++ P +P + V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL 3260
Query: 1211 NTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ L T + W K I E + TL I D +YTCV
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--PQPNDEWIVNS 1325
+ + + V P + + ++ D ++ ++ +A P P W+ N
Sbjct: 3321 ATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP- 1384
+ H + + + + I + + +D +Y N G + N+ + P+
Sbjct: 3381 LPLPLSSHIR--LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDN 3438
Query: 1385 --GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
G I + SS ++ S + ++ + Q + ++V +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMV-LQLLK 3495
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYY--KVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+T S ++ A NE A E ++++ KV++ I + + I P +E
Sbjct: 3496 AETEDSGKYTCIASNE-----AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP---LE 3547
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
LTCI G+P PK+TW +DG+ L T Y C+A + G+
Sbjct: 3548 LTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGD 3607
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ +V + P I ++E + + + +PPP + W +NG +L+
Sbjct: 3608 DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR 3667
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
I + + ++I ++ YT ASN AG ++ E L V P+ GP + +
Sbjct: 3668 VRILSGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVIL 3725
Query: 1679 SRESVTIE 1686
+S +E
Sbjct: 3726 LNKSTVLE 3733
Score = 165 bits (402), Expect = 1e-39
Identities = 238/1078 (22%), Positives = 414/1078 (38%), Gaps = 81/1078 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 847
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 906
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 962
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 1015 SKKGELISTSSAKFSAGADG---SLYVVSPGGE-ESGEYVCTATNTAGYAKRKVQLTVYV 1070
Query: 926 EKVTF--VKHLQKSYETE----EGKTVILECQTSHTVS--TKWYHNKKEISGMDHREIIQ 977
F + L + E G+ V L C+ W + IS R
Sbjct: 1071 RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL 1130
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVA 1034
D G+ C+ + + VK + P+ R + +V+
Sbjct: 1131 P--SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ V+ W + G + + G L I + D G Y+C+ +
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATN 1245
Query: 1094 ESCTAEV----------TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ T E TV +L P T Q + N+ + + T ++W +G
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KPTIKWLHNG 1304
Query: 1144 SEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
E+ I + DG L I D GEY C E G ++ L V P +
Sbjct: 1305 RELTGREPGISILEDG--TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIK 1362
Query: 1199 TLRLPEFILVPAN--TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIR 1256
+ V N T+ + VE + + WYK ++ TE T+ + + L +
Sbjct: 1363 DKEQVTNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDN--VQVTESSTIQTVNNGKILKLF 1419
Query: 1257 KCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQA 1313
+ T +D Y+C ++ T++ + V PP I+ ++ E + DV L +
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKG 1479
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P P+ W + K + +D + L +K D G Y+ + N G ++
Sbjct: 1480 TPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+TI PS G +I ++ E E G I + + Q I ++
Sbjct: 1539 KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS--QALY 1596
Query: 1433 ITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
I K Q I + + S + + N ++ +E + + V I+ + PL N
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVAN---VAGTAEKSFHVDVYVPPMIEG-NLATPL-NK 1651
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYK 1549
+ L C G P P +TW +DG +K Y
Sbjct: 1652 QVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYI 1711
Query: 1550 CIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
C+A + GE E V + P I +E V + + + G PPP ++W K+
Sbjct: 1712 CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD 1771
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
G ++ + I + V I + + S++ Y A+NTAG E + V+ P+
Sbjct: 1772 GQLIDERDGFKILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 164 bits (399), Expect = 3e-39
Identities = 241/1072 (22%), Positives = 409/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 3301
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M +
Sbjct: 3302 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD- 3357
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 3358 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 3418 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 3473 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 3524
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3584
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 3585 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3699
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 3757
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 3758 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 3813
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3871
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 3932 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 3989
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 3990 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 4040
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 4159 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 4214
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 4215 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4266
Score = 160 bits (389), Expect = 4e-38
Identities = 222/1029 (21%), Positives = 397/1029 (38%), Gaps = 84/1029 (8%)
Query: 680 ISVAIESDMHMYCSV-LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+++ ++ + SV L I V EG Y +AV+ G + EPP VI
Sbjct: 468 VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS----EPPPVI 523
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKV 797
+ ++ V GE +L+ ++ +TW +N++ V+ A P + + LK K
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF 583
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y + G + S +TV+EP + P + Q T + + ++ T
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP-----KNQSFTGGSE--VSIMCSAT 636
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P I W N+ I S DG L I N + D+G Y C+ASNSAG
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG---TLFIKNAAPK-DAGIYGCLASNSAGTDKQ 692
Query: 918 GARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHRE 974
+ + I+ K+ V Q G ++EC+TS KW+ E+
Sbjct: 693 NSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF-- 747
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+I + D G C+ ++ T + + + P FI++ D ++
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807
Query: 1032 DVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
L + + W R D I + + L+I N D+G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 1090 ILRDE--SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDALV--RWFKD 1142
++ +E TV + P I V +G + T L G+ + RW K+
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-----NSKCTAILTVEEPSIN 1197
+ + + +I + DG L I L D GEY+C N+K T+++ P+I
Sbjct: 928 SAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 1198 FTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLII 1255
++ I +P + + V W KK +I + KF+ +D +L +
Sbjct: 985 HGQQILSTIEGIPVTLPCKAS---GNPKPSVIWSKKGELISTSSAKFSAGAD---GSLYV 1038
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER--------EYRIKRGSDVT 1306
++ EY C + K KV++ V P++ +R E + G +VT
Sbjct: 1039 VSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
L + ++ P P W +++I + S S+ I + +D+G+Y N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKITETRTSDSGMYLCVATNIA 1156
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G+ + + + P P L++ + D P N + + V+ + + +T
Sbjct: 1157 GNVTQAVKLNVHVPPKIQRGPKHLKV---QVGQRVDIPCNAQGTPL--PVITWSKGGSTM 1211
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE- 1485
+ ++ ++ + Y +I+ E TE ++E PTVE
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE-TEITLHVQE----PPTVED 1266
Query: 1486 -KPLKNITTE---PNEDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXX 1538
+P N T + N+ IE C G P+P + W +G++L + + E+
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIA 1326
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N+ G E + + PVI + + + +EG
Sbjct: 1327 SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P ++WYK + ++ + I T ++++ + +Y+ +A N AGTS
Sbjct: 1387 TPSPIIMWYK--DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 1659 TLKVYDKPS 1667
+ V P+
Sbjct: 1445 NIDVLVPPT 1453
Score = 151 bits (367), Expect = 2e-35
Identities = 241/1167 (20%), Positives = 421/1167 (36%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 3506
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 3561
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 3562 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 3592
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 3593 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 3647
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 3648 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 3708 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 3760
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 3761 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 3817
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 3878 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 3937
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 3938 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3994
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4050
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 4106
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S +L I D YTC+ + S+T K
Sbjct: 4107 PPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4162
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 4163 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 4218
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 4219 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 4267
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 4268 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4324
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K I ++ P V K + EP + L C G P P + W
Sbjct: 4325 TYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN 4384
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 4445 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 4499
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 4500 QKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 149 bits (362), Expect = 8e-35
Identities = 233/1097 (21%), Positives = 389/1097 (35%), Gaps = 84/1097 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + PK Q GS++ + C P+P IAW IV + SD
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT--SD----- 663
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N G Y +A N G L+ E P+++ ++V G+
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRY----IEAPKLMVVQSELLVALGDIT 719
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G P P + W K + ++ + ++ + D G YT A N G
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NN 870
A + V PP+FI +++++ + L V P P+I W R N
Sbjct: 780 RATGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I S +++ L I N+ + D G Y C A N GK VT+
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ EG+ + L C + +W N + + + +G
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
+ + V T VV +P Q E L + + +
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPS 1011
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
V+W + GE+I K+ G LY+ + + GEY C + + A+ V V
Sbjct: 1012 VIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 1104 ELPPEII---TRLQNQK-----VNKGNKATFEIEL-TKGDALVRWFKDGSEIQ-FSNHIQ 1153
+ P + L K V G + T E+ + ++ W K+ I FS
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHT 1128
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
G +KI + D+G Y C GN L V P R P+ + V
Sbjct: 1129 FLPSG---SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP--KIQRGPKHLKVQ 1183
Query: 1210 ANTDAYLTVEIPDETLDV-TWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L V TW K S ++ D E D TL I + T D YT
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATPSDAGIYT 1240
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIK-----RGSDVTLLVDYQAFPQPNDEW 1321
CV + T + ++ + V+ PP + D E Y + + P+P +W
Sbjct: 1241 CVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW 1300
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ N + + + SI L I V D G Y N G + + N+ + P
Sbjct: 1301 LHNGRELTG-REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Query: 1382 SPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
K + + + + + E E T + I++Y + TE +++ + +
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQVTESSTIQTVNNGK-- 1414
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNED 1498
I L + Y+ ++I+ S+ +Y+ + + + + N ++ N D
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQ--KYFNI--DVLVPPTIIGTNFPNEVSVVLNRD 1470
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCIAFND 1555
+ L C G P P + W++DGK L E Y+C N
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G+ + I P I N + + G+P P + WYK+G + +
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG---- 1671
+ +K + I + S S+ YT +N AGT+ + VY P EG
Sbjct: 1591 SSQ--ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY-VPPMIEGNLAT 1647
Query: 1672 PVIMREISRESVTIEWK 1688
P+ + + S+T+E K
Sbjct: 1648 PLNKQVVIAHSLTLECK 1664
Score = 147 bits (356), Expect = 4e-34
Identities = 238/1118 (21%), Positives = 422/1118 (37%), Gaps = 93/1118 (8%)
Query: 599 IVEAPLSDHGS-EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
I + LSD G E D+ E PP + P V G +L C +
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
++ + ++ W ++ E + +++ L++ +VK G Y + + G
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-----LELKSVKFNDAGEYHCMVSSEGG 598
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA 777
++ + L + +EPP+V K+ G V + G P+P I W N+ +
Sbjct: 599 SSAASVFLTV----QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 778 LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-AETSAVITVEEPTEENAEPPLFI 836
+ + +K KD G+Y A NS G + S + +E P + L +
Sbjct: 655 -SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLV 713
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
+ITV E + + P P + W++ + + PS + + + L+
Sbjct: 714 -ALGDITVME-------CKTSGIPPPQVKWFKGDLELRPSTFLIID---PLLGLLKIQET 762
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSH 954
++D+GDY CVA N AG+++ ++T+DV E G V L C Q
Sbjct: 763 QDLDAGDYTCVAINEAGRAT--GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Query: 955 TVSTKW--YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETST 1008
+ KW N S I + R D G C ++Q ++ T
Sbjct: 821 EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 1009 MLVVKETIPEFIRKLQDF-EVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDF 1065
+ V + I V E L + + + W ++ ++ +N Y
Sbjct: 881 TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML--LQNPYIT 938
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITRLQNQKVNKGN 1122
+ L+I + D GEY+C+ + + T T VV + P I Q +G
Sbjct: 939 VRSD--GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + V W K G I S+ DG L + +++GEY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTA 1053
Query: 1179 --EVGNSKCTAILTV-EEPSI-----NFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTW 1229
G +K LTV P + + P I V A + L E+ +TW
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 1230 YKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
K+ +I + + T + ++ I + D Y CV + V++ V P
Sbjct: 1114 AKETQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLT 1346
PKI + +++ G V + + Q P P W S ++ +H + + +L+
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEH---HVSNPDGTLS 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSSSINICW 1401
I + +DAGIY N G + E+ + + + P+ PP E ++ I +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-RIEF 1286
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
P I ++ +E+ E IS+ T I ++ + + AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILE-DGTLLVIASVTPYDNGEYICVAVNE-- 1343
Query: 1461 ISDASETTEYYKVIKETKIQSPTV---EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
A T Y + K+ P V ++ + N++ N+ L C G P P + WY+
Sbjct: 1344 ---AGTTERKYNL----KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Query: 1518 DGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
D ++ + T N Y C A N G + + + P I
Sbjct: 1397 DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
+N + + + + ++G P P++ W+K+G L + N+ ++ V+ +K
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
+R+ +Y SN AG + ++ L +Y PS G V
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553
Score = 121 bits (291), Expect = 3e-26
Identities = 205/965 (21%), Positives = 343/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 3618 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 3674
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 3675 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 3727
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 3728 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 3787
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 3788 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 3898
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 3899 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 4018 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 4074
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 4075 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 4131
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 4132 S---LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 4185
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 4242
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 4243 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 4302
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P +
Sbjct: 4303 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP-------VF 4351
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ D S W EP G + I+ V+ T +W + I+ L S
Sbjct: 4352 KGDYPS---NWIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS--- 4403
Query: 1451 FRAYAVNEVDISD-ASETTEYYKVIKET---KIQSPTV--EKPLKNITTEPNEDIELTCI 1504
Y D D T V++ + +QSP + +P++ + + I L C
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK-IILNCQ 4462
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 4523 PVIVQ 4527
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C GYP+P+I W I S ++M D TL I+ P+DAG + C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD----GTLFIKNAAPKDAGIYGC 681
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+A N+AG + L +EAP
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP 702
Score = 51.6 bits (118), Expect = 3e-05
Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V EC+ P P ITW++ +I S ++ D L I++
Sbjct: 3064 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 3120
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 3179
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 3180 PPTIAWLKNHKRIENSD-SLEVRILS 3204
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 773 VAINEAGRATGKITLDVGSP 792
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 489 NEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
++K ++ V PT + ++ V K +P V +C G P P ITW +
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKP--------VALQCIANGIPNPSITWLKDDQ 1865
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +Q V L I + EDAG +TCVA NAAG +L V P S
Sbjct: 1866 PVNTAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 4313
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF + + V+ P
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Score = 47.2 bits (107), Expect = 6e-04
Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 1658
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC+ G P P +TW + +K + + ++ + + +E+ D G + CVA
Sbjct: 1659 LTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT 1715
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q +
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI 1775
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVS 1798
Score = 47.2 bits (107), Expect = 6e-04
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G C+V+G P P I W R+ I+ S + + +L I EDAG +
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVNEDAGDY 4417
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA N AG + L +++P
Sbjct: 4418 TCVATNEAGVVERSMSLTLQSP 4439
Score = 45.6 bits (103), Expect = 0.002
Identities = 38/185 (20%), Positives = 69/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ V +++ PV + +G ++ ++G P
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFK-GDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 4379 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 1662 VYDKP 1666
+ P
Sbjct: 4436 LQSPP 4440
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 4239 CVANNAAGEDTHTVSLTV 4256
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 4044
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 4454 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 4509
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 4510 VARNLMGSVLVRVPVIVQ 4527
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 3910 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 3962
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 3963 GRYTCVARNAAGSAHRHVTLHVHEP 3987
>AL118512-1|CAI17864.1| 5635|Homo sapiens protein ( Human DNA sequence
from clone GS1-248A21 on chromosome 1q31.1-31.3. ).
Length = 5635
Score = 235 bits (574), Expect = 2e-60
Identities = 291/1201 (24%), Positives = 482/1201 (40%), Gaps = 129/1201 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ EC+V+G P P +TW + + ++ ++ D+ ++ L ++ + D G + C
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHI--LQLKNIHVSDTGRYVC 2363
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA N AG +L V AP S G+ + P S
Sbjct: 2364 VAVNVAGMTDKKYDLSVHAPPSIIGNHRS--------------------PENIS------ 2397
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V E + + L C IP P I W FK V N SV I S M L++
Sbjct: 2398 -VVEKNSVSLTCEASGIPLPSITW-FKDGWPVSLSN-SVRILSGGRM----LRLMQTTME 2450
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGN 761
G YT V N GE L + PP ++ L+ + V++ +SV L+ +V GN
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLV----PPHIVGENTLEDVKVKEKQSVTLTCEVTGN 2506
Query: 762 PRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P ITW K+ +P+ +A S G IT + +V G YT A + G S
Sbjct: 2507 PVPEITWHKDGQPLQEDEAHHIISGGRFLQITNV---QVPHTGRYTCLASSPAGHKSRSF 2563
Query: 819 VITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+ V PT +++TV LV P +ITW+++ + +
Sbjct: 2564 SLNVFVSPTIAGVGSD---GNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2620
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL--- 934
I G ++++ D ++G Y CVA+N AG+ V + + + L
Sbjct: 2621 NIRILPGGRTLQILNAQED---NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGP 2677
Query: 935 ---QKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
K + + T+ LEC+ + S WY + + + DH I G
Sbjct: 2678 GLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2735
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIRKLQDF--------EVKEKDVAI---- 1035
D G C+ + E V +P +KL + + KDV I
Sbjct: 2736 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 1036 -LEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L E N + + W +DG + +K G R L I V D G Y+C+ +
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPL-TSSDKVLILPGG--RVLQIPRAKVEDAGRYTCVAVN 2852
Query: 1094 ES--CTAEVTVVELPPEII----TRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSE 1145
E+ + + V L P II + L + NK+ L+ G R W KDG
Sbjct: 2853 EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2912
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
+ +H + +G+ L+I + + D G Y C G++K L V P +
Sbjct: 2913 LLEDDHHKFLSNGR--ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2970
Query: 1202 LPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E + V N LT E+ D++W K + I+ ++ RTL I +
Sbjct: 2971 -SENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG--GRTLQIIRAKV 3027
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE----YRIKRGSDVTLLVDYQAFP 1315
D EYTC+ ++ +K K + V PP I D++ E ++ G+ V+L + A P
Sbjct: 3028 SDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W N ++I + H + D + L IKK E +D G Y R N G D ++
Sbjct: 3088 PPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3145
Query: 1376 TILDKPS--PPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+ PS P + I+E S+ + + D TG I ++ ++ I+ ++ + V+
Sbjct: 3146 NVYVPPSIEGPEREVIVETISNPVTLTCDA---TGIPPPTIAWLKNHKRIENSDSLEVRI 3202
Query: 1433 IT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
++ ++ I + + S + A N + +YY + + E P ++
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNM-----EGKAQKYYFLSIQVPPSVAGAEIP-SDV 3256
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXXXXXXXX 1547
+ E++EL C G+P P + W +DGK + + + N
Sbjct: 3257 SVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3316
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIW 1606
Y C+A N GE + + + P I + ++ ++ + D + + G PPP++ W
Sbjct: 3317 YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW 3376
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
KNG L + + VIRI + S + YT ASN AG + L+V+ P
Sbjct: 3377 LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPP 3434
Query: 1667 S 1667
+
Sbjct: 3435 N 3435
Score = 215 bits (525), Expect = 1e-54
Identities = 273/1202 (22%), Positives = 469/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 1027
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 1082
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 1083 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 1125
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA N G + + L + PP++
Sbjct: 1126 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV----PPKIQR 1175
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 800 EGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+E PT E+ EPP + FQE ++ A+ T
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 1293
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + + LVI +V + D+G+Y CVA N AG +
Sbjct: 1294 -PKPTIKWLHNGRELTGREPGISILEDGTL-LVIASV-TPYDNGEYICVAVNEAGTTERK 1350
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 1351 YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTM-----LVVKETIPEFIRKLQDFEVKE 1030
G+ D G C + TS ++V TI + V
Sbjct: 1411 NNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN 1468
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ + D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 1469 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 1525
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 1586 QPIMSSSQ-ALYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 1638
Query: 1204 EFI----LVPANTDAY----LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + + + KK
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK-- 1696
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLV 1309
L I E D+ +Y CV ++K EV V PP I D + + + + L
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + ++I + K ++ + + +V NT G+Y+ N G
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 1814
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 1815 KKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQ--- 1871
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 1872 -GNL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 1926
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR-XXXXXXXXXXXXX 1545
N T + ++L C G P P +TWY+D + L + T+ NR
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDA 1986
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLT 2044
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 2045 WLKDGSPVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 1666 PS 1667
P+
Sbjct: 2104 PN 2105
Score = 209 bits (511), Expect = 7e-53
Identities = 270/1179 (22%), Positives = 456/1179 (38%), Gaps = 93/1179 (7%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 1233
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 1234 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTVE------------DLEPPYNTT 1274
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F ++ Q ++ C P+P I WL G E+ E ++I D ++L
Sbjct: 1275 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREP-GISILEDG----TLL 1323
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVI 753
I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVTNVSVLLNQLTN 1379
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439
Query: 814 AETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
++ I V P P + F E++V + L +V P P I W+++ +
Sbjct: 1440 SQKYFNIDVLVP------PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 1494 LFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 1551
Query: 933 HLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ + LEC+T + WY + + I I +G+
Sbjct: 1552 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611
Query: 991 XXDVGVIKCIVKDQETST--MLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-- 1046
D C V + + V +P I + ++ V + + + A
Sbjct: 1612 --DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNP 1669
Query: 1047 ---VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
+ W +DG +K N E G +KL I + D G+Y C+ + E+
Sbjct: 1670 SPILTWLKDGVPVKANDN-IRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYE 1726
Query: 1103 --VELPPEIITRLQNQK--VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
V +PP I + V N + +T + W KDG I + ++ ++
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLN 1786
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVPANTD 1213
G+K L I + + G Y C N+ K +TV P + L E ++V
Sbjct: 1787 GRK--LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPV 1844
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
A + +TW K + +T + L R L I K +D YTCV +A
Sbjct: 1845 ALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 1903
Query: 1274 KSTTKLKVEV-VEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
T+ +++ V PP + D + + + V L P P W +++++
Sbjct: 1904 AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSG 1963
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N++
Sbjct: 1964 S--TSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMV 2021
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ ++ E ++ + + + V + + ++ + + + + R
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQISDTGR 2080
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 2081 YTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 2132
Query: 1511 PKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
P +TW +DG L K + ENR Y C A N G+ E + V I
Sbjct: 2133 PTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW 2192
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P I S+E + G+ + GIPPP +IW K G+ + D +
Sbjct: 2193 VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGR 2252
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++I ++S ++ Y+ ASN AGT+ E L+VY +P+
Sbjct: 2253 QLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPT 2291
Score = 200 bits (488), Expect = 4e-50
Identities = 249/1088 (22%), Positives = 430/1088 (39%), Gaps = 92/1088 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+ S V + + LEC IP P + WL G + N +
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+L +T+ + G YT VAVN GE I L++ PP ++ +++ V ++
Sbjct: 2067 --ILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV----PPNIMGEEQNVSVLISQA 2120
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
V L Q P PT+TW K+ P+ P S + S+ ++ +V+D G YT +A N
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YRNN 870
G E + + + P L ++TV E I L+ + P P++ W + +
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIWKKKGS 2235
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKV 928
+++ S + G +L I ++ + D+ Y CVASN AG K + +V I
Sbjct: 2236 PVLTDSMGRVRILSGGR-QLQI-SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTIT 2293
Query: 929 TFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
H + T GK++ LEC+ + W + + EI+ EG
Sbjct: 2294 NSGSHPTEIIVT-RGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQL 2350
Query: 987 XXXXXXDVGVIKCI------VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + D++ + +I R ++ V EK+ L E
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 1041 NS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ESC 1096
+ + W +DG + N G R L + T++ D G+Y+C++R+ E
Sbjct: 2411 SGIPLPSITWFKDGWPVS-LSNSVRILSGG--RMLRLMQTTMEDAGQYTCVVRNAAGEER 2467
Query: 1097 TAEVTVVELPPEII--TRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQ 1153
V +PP I+ L++ KV + T E+T + W KDG +Q
Sbjct: 2468 KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHH 2527
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSIN--FTLRLPEFI 1206
+ G+ L+I + + G Y+C + S+ ++ P+I + PE +
Sbjct: 2528 IISGGR--FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDV 2585
Query: 1207 LVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V N+ L E +TW+K + +E ++ RTL I ED+
Sbjct: 2586 TVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG--GRTLQILNAQEDNAGR 2643
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVD---------YEREYRIKRGSDVTLLVDYQAFPQ 1316
Y+CV + EV + P I++ +E +IK + +TL + A P
Sbjct: 2644 YSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPS 2703
Query: 1317 PNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+ W + + +K H +I + +L IK+ + +D G Y N G +++ +V
Sbjct: 2704 ASLSWYKDGQPLKSDDHV--NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVN 2761
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENT--GNSTIIYYVVEYQEIDTTEWISVKN-I 1433
I PP + EI + E ++ N +Y T W + +
Sbjct: 2762 I---QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 1434 TKTQ----------TSIQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQSP 1482
T + I K + R+ AVNE ++ +Y +V+ I+
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA----GEDSLQYDVRVLVPPIIKGA 2874
Query: 1483 TVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXX 1540
+ P + +T N+ + C+ G P P+ +W +DG+ L N
Sbjct: 2875 NSDLP-EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQKP-VITISNEDIKQKHKVGDEWLVTAVIEGI 1599
Y C+A N G + + + P VI +E++ V + +T + G
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV--VVNNFISLTCEVSGF 2991
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
PPP++ W KN ++ + I +T ++I K S +YT A N AG S + +
Sbjct: 2992 PPPDLSWLKNEQPIKLNTNTLIVPGGRT--LQIIRAKVSDGGEYTCIAINQAGESKKKFS 3049
Query: 1660 LKVYDKPS 1667
L VY PS
Sbjct: 3050 LTVYVPPS 3057
Score = 197 bits (481), Expect = 3e-49
Identities = 269/1219 (22%), Positives = 480/1219 (39%), Gaps = 120/1219 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S ++ EC+ G P P ITW++ I S +Y D + +V D+ T+TC
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQ-ALYIDKGQYLHIPRAQV--SDSATYTCH 1619
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
N AG A + + V P ++EG T P +
Sbjct: 1620 VANVAGTAEKSFHVDVYVP-----------------------PMIEGNLAT----PLNKQ 1652
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + LEC+ P P + WL G + ++NI + L+I + ++
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK------LEIMSAQEID 1706
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGNP 762
G Y VA + GE + K + PP + + IV + L V G+P
Sbjct: 1707 RGQYICVATSVAGEKEI----KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 763 RPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
PTI W K+ + + ++ +V + G+Y A N+ G + +TV
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE-TITQ 881
P P + + E V + + L P PSITW ++++ ++ ++ +
Sbjct: 1823 HVP------PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-ET 940
G +++ T ++ D+G Y CVA+N+AG++ + + V + ++ K ET
Sbjct: 1877 QSSGRVLQIAKTLLE---DAGRYTCVATNAAGETQQ--HIQLHVHEPPSLEDAGKMLNET 1931
Query: 941 E-EGKTVILECQTS-HTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
V LEC+ + + V WY + + +SG + G+ D G+
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS--DAGIY 1989
Query: 998 KCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDG 1053
KC+ + +T L + P V + LE E A + W +DG
Sbjct: 1990 KCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ N G I L + + + D G Y+C+ + + + + V +PP I+
Sbjct: 2050 SPVSSFSNGLQVLSGGRI--LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107
Query: 1111 TRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
QN V L + DA+ + W KDG + L+I + LKI
Sbjct: 2108 GEEQNVSVLISQAVEL---LCQSDAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKIE 2162
Query: 1167 DCDLDDAGEYSCEVGN--SKCTAILTVE---EPSINFTLRLPEFILVPANTDAYLTVEIP 1221
D + D G Y+CE N K V P+I + L + ++ N + L
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSG 2222
Query: 1222 DETLDVTWYKKKS-VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
++ W KK S V+ D+ + ++S R L I + D Y+CV + T K
Sbjct: 2223 IPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAALYSCVASNVAGTAKK 2280
Query: 1280 KVEV-VEFPPKIVD---YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ + V P I + + E + RG ++L + Q P P W+ + + K K +
Sbjct: 2281 EYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE 2340
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK----PNILE 1391
I + L +K + +D G Y N G D + ++++ PS G NI
Sbjct: 2341 --ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISV 2398
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRF 1451
++ +S+++ E +I ++ + +S+ N + + + L+ +
Sbjct: 2399 VEKNSVSLTC-EASGIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTME 2450
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVP 1509
A V + A E K+ + + P + E L+++ + + + LTC G P
Sbjct: 2451 DAGQYTCVVRNAAGEER---KIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP 2507
Query: 1510 QPKVTWYRDGKKLKTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
P++TW++DG+ L+ +A + Y C+A + G S + +
Sbjct: 2508 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Query: 1568 QQKPVIT-ISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTK 1624
P I + ++ + V + V E PP + W+K+G LE+++ I
Sbjct: 2568 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2627
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+T ++I + ++ +Y+ A+N AG +KVY P +G + +S + V
Sbjct: 2628 GRT--LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVK 2685
Query: 1685 IEWKPPLDDGGLELTKYAI 1703
I+ L LE YAI
Sbjct: 2686 IKVNNTLT---LECEAYAI 2701
Score = 196 bits (477), Expect = 9e-49
Identities = 270/1212 (22%), Positives = 474/1212 (39%), Gaps = 118/1212 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 890
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 891 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 944
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 945 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 993
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P ++ G Y
Sbjct: 994 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYV 1050
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P + L ++ EI+V + L V P P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 1167
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXX 983
V ++ K + + G+ V + C T +K + + E
Sbjct: 1168 HVPPK--IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225
Query: 984 XXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILE 1037
D G+ C+ + ET L V+E P + L+ ++ VA
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQR 1283
Query: 1038 VEI-----NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
+E + + W +G + ++ + G + L I + + +D GEY C+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAV 1341
Query: 1093 DESCTAEVTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSE 1145
+E+ T E V +PP I + Q V N+ E+E T ++ W+KD +
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQ 1400
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLR 1201
+ S+ IQ +GK LK++ +DAG YSC+ G S+ + V P
Sbjct: 1401 VTESSTIQTVNNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 1202 LPEFILVPANTDAYLTVEIPDETL-DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P + V N D L ++ D+ W+K K + L+ + + L ++
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD--RGQVLHLKNAR 1516
Query: 1260 EDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFP 1315
+D+ Y C + +A K +K+ + PP I + + + S + L + + P
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKL-TIYIPPSIKGGNVTTDISVLINSLIKLECETRGLP 1575
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W + + I ID K L I + + +D+ Y + N G A+ +V
Sbjct: 1576 MPAITWYKDGQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVK 1431
+ P G N+ + + I E + GN S I+ ++ + + +
Sbjct: 1634 DVYVPPMIEG--NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKAND----- 1686
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLK 1489
NI + + + L+ S+ V S A E Y+V + P +E
Sbjct: 1687 NI-RIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETS 1742
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXX 1547
N +EL C G P P + W +DG+ + + N
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGL 1802
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C+A N G+ + V + P I S +E + K+K + + GIP P +
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSIT 1859
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+ + N + N+ + V++I + + +YT A+N AG + + L V++
Sbjct: 1860 WLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Query: 1666 PSKPEGPVIMRE 1677
PS + ++ E
Sbjct: 1919 PSLEDAGKMLNE 1930
Score = 193 bits (470), Expect = 7e-48
Identities = 242/1089 (22%), Positives = 423/1089 (38%), Gaps = 92/1089 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C + P I W G + + NI + L+I N ++ G Y+ VA
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGG------RTLQILNAQEDNAGRYSCVA 2648
Query: 713 VNREGEASLPIVLK------IKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
N GE +K I G+ P + P K + ++ ++ L + P ++
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPG-LSP-KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 767 TWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+W K+ +P+K+ + H++ I K ++ D G YT A N G E + ++ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQI-KEAQISDTGRYTCVASNIAGEDELDFDVNIQVP 2765
Query: 826 T--EENAEPPLFINRFQEITVKE---KGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
++ E ++ + K+ I L P P++TWY++ ++ S+ +
Sbjct: 2766 PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVL 2825
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS--HGARVTIDVEKVTFVKHLQKSY 938
G +++ V+ D+G Y CVA N AG+ S + RV + L +
Sbjct: 2826 ILPGGRVLQIPRAKVE---DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEV 2882
Query: 939 ETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
K+ ++EC +S + + + W + + + DH + + GR D+G
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGR 2940
Query: 997 IKCIVKDQETSTMLVVKETI---PEFIR-KLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
C+ ++ S + P I K ++ V + L E++ D+ W +
Sbjct: 2941 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPE 1108
+ + IK N G R L I V D GEY+CI +++ ++ V +PP
Sbjct: 3001 NEQPIKLNTNTL-IVPGG--RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Query: 1109 IITR----LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
I L V +G + E E ++ W+K+G I S H+++ DG Q L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QML 3115
Query: 1164 KIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I ++ D G+Y C N K + PSI R E I+ + LT
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTC 3173
Query: 1219 E---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ IP T + W K IE+++ + L I + D YTC+ + +
Sbjct: 3174 DATGIPPPT--IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3231
Query: 1276 TT-KLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
K ++ PP + E + + G +V L+ + P P +W+ + K I +
Sbjct: 3232 KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN---- 1388
+ + + ++L I +D G Y N G D N+ + P+ G +
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
++ + +SINI E TG W+ + I+ L
Sbjct: 3352 LMTLVDTSINI---ECRATGTPP-----------PQINWLKNGLPLPLSSHIRLLAAGQV 3397
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTC 1503
R V++V + + K +Q P ++ + + IT + C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457
Query: 1504 IFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVET 1561
I G P P + W RDG+ L A T Y CIA N+ GEV
Sbjct: 3458 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3517
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
++ + + P I S E + V + +T + GIP P++ W K+G L + +
Sbjct: 3518 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--V 3575
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREIS 1679
T V+RI + + +YT AS+ AG E ++V+ P + + P + +
Sbjct: 3576 QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR 3635
Query: 1680 RESVTIEWK 1688
VT+E K
Sbjct: 3636 NRQVTLECK 3644
Score = 184 bits (449), Expect = 2e-45
Identities = 262/1206 (21%), Positives = 456/1206 (37%), Gaps = 135/1206 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G+ + C+ G P P + W ++ + ++ S + I E DA +
Sbjct: 2210 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE--KSDAALY 2267
Query: 582 TCVAKNAAGFASS--TTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
+CVA N AG A ++ + +++ GS T ++ +GIPP
Sbjct: 2268 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPP----- 2321
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P ++ +G ++ KG EI+ DE +L++ N
Sbjct: 2322 PTVTWMKDGHPLIKA---------------KGVEIL-DEG-------------HILQLKN 2352
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS---MIVRQGESVILSA 756
+ G Y VAVN G L + PP +I +S + V + SV L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHA----PPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ G P P+ITW K+ PV + + L ++D G YT N+ G
Sbjct: 2409 EASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK 2468
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
++V P E N +++ VKEK ++ L VT NPVP ITW+++ + +
Sbjct: 2469 IFGLSVLVPPHIVGE-----NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQED 2523
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E G ++ ITNV +G Y C+AS+ AG S + + V + +
Sbjct: 2524 EAHHIISGGRFLQ--ITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPT--IAGVGS 2578
Query: 937 SYETEEGKTVILECQTS--------HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
E+ TVIL TS + W+ + + + I+ GR
Sbjct: 2579 DGNPED-VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRK-------LQDFEVKEK--DVAILE 1037
+ G C+ ++ E VK IP I K L EVK K + LE
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1038 VEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
E + +A + W +DG+ +K + + GH L I+ + D G Y+C+ + +
Sbjct: 2696 CEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2752
Query: 1097 TAEVTV---VELPPEI--ITRLQNQKVNKGNKATFEIELTKGDAL-----------VRWF 1140
E+ +++PP + + N N ++ + +L + W+
Sbjct: 2753 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI 1196
KDG + S+ + + G+ L+I ++DAG Y+C E G + V P I
Sbjct: 2813 KDGHPLTSSDKVLILPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2870
Query: 1197 --NFTLRLPEFILVPANTDAYL-TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
LPE + V N A + + +W K + + + +S+ R L
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSN--GRIL 2928
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE-YRIKRGSDVTLLVDY 1311
I D Y CV + + K + V PP ++ + E + + ++L +
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2988
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
FP P+ W+ N + IK +T I +L I + + +D G Y N G +
Sbjct: 2989 SGFPPPDLSWLKNEQPIK--LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWIS 1429
+ ++T+ PS I + DS S+++ N T + E + W
Sbjct: 3047 KFSLTVYVPPS------IKDHDSESLSVV-----NVREGTSVSLECESNAVPPPVITWYK 3095
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEK 1486
+ T ++ L + V++ + K + P++E
Sbjct: 3096 NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEG 3155
Query: 1487 PLKNITTEP-NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXX 1541
P + + E + + LTC G+P P + W ++ K+++ + +
Sbjct: 3156 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQ 3215
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y CIA N G+ + + IQ P + + +G+ + GIP
Sbjct: 3216 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W K+G + + + I S + I S + KYT A+N AG L
Sbjct: 3276 PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3335
Query: 1662 VYDKPS 1667
VY P+
Sbjct: 3336 VYVTPT 3341
Score = 180 bits (439), Expect = 4e-44
Identities = 241/1193 (20%), Positives = 429/1193 (35%), Gaps = 91/1193 (7%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+T+ EC+ P ++W++ +K + N TL I+E D G +TCV
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---NGHTLQIKEAQISDTGRYTCV 2746
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG ++ ++ P S ++L+ + +A+
Sbjct: 2747 ASNIAGEDELDFDVNIQVPPS-------------FQKLWEIGNMLDT-----GRNGEAKD 2788
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + I L C A P P + W G + + + + VL+I K
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG------RVLQIPRAKVED 2842
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G YT VAVN GE SL +++ + + + V +S ++ G+P P
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAP 2902
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+W K+ +P+ I + ++ D G Y AEN+ G A+ + V
Sbjct: 2903 RNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV 2962
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P P + + + +TV I L V+ P P ++W +N + I +
Sbjct: 2963 P------PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPG 3016
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET---E 941
G ++++ V D G+Y C+A N AG+S +T+ V + H +S
Sbjct: 3017 GRTLQIIRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPP-SIKDHDSESLSVVNVR 3072
Query: 942 EGKTVILECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
EG +V LEC+++ WY N + I+ H EI+ +G+ V +
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 1000 IV---KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
I +D + + V E + E V + + W ++ + I
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRL 1113
+ + + KL I + D G Y+CI + A+ +++PP +
Sbjct: 3193 E-NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 3251
Query: 1114 QNQKVNKGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
V+ E+ L++W KDG I ++ + L IY
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 1171 DDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D G+Y+C N + + P+I E ++ +T +
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 1226 -DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+ W K + + L++ + + I + D YTCV + +
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429
Query: 1285 EFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
F P +D E + +GS ++ P P+ W+ + + + H ++ +
Sbjct: 3430 VFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL--TVSTH 3487
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
L + K E D+G Y N G + +L+ P G EI S +N
Sbjct: 3488 GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVIVN--- 3543
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD- 1460
N T I + ++ W+ +Q L R V +
Sbjct: 3544 ----NPLELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGR 3596
Query: 1461 -----ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
S A + + Y V ++P ++IT N + L C VP P +TW
Sbjct: 3597 YTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPPPVITW 3655
Query: 1516 YRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
R+G++L+ Y C+A N G+ ++ + P I
Sbjct: 3656 LRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNI 3715
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRI 1632
+ + + ++ + EG+P P + W K+G L N Y+I + + I
Sbjct: 3716 KGGPQSLVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---ENGFLHI 3770
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ + + +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 3771 QSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 3823
Score = 178 bits (434), Expect = 2e-43
Identities = 266/1185 (22%), Positives = 444/1185 (37%), Gaps = 112/1185 (9%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
++ +C V G P P I W + +I F++ N LVI + + G + C+A
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL---NGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 587 NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ-YV 645
N AG DH E V +PPT ++ V
Sbjct: 1809 NTAG---------------DHKKEFEVTVH---------------VPPTIKSSGLSERVV 1838
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ + L+C IP P I WL K ++ V ++ I+S VL+I
Sbjct: 1839 VKYKPVALQCIANGIPNPSITWL-KDDQPVNTAQGNLKIQSSGR----VLQIAKTLLEDA 1893
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGESVILSAQVVGNPR 763
G YT VA N GE I L + EPP + + K + V V L + GNP
Sbjct: 1894 GRYTCVATNAAGETQQHIQLHVH----EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPV 1949
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P ITW K+N+ + + + + I ++ ++ D G+Y A NS G E + V
Sbjct: 1950 PVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVH 2009
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
P + V ++L P PS+TW ++ +S Q
Sbjct: 2010 -------VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL 2062
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
G I L +T+ D+G Y CVA N+AG+ + + V + S +
Sbjct: 2063 SGGRI-LALTSAQIS-DTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQA 2120
Query: 944 KTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++ + + W + + I E R D G C +
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLS-ISENR-SVLKIEDAQVQDTGRYTCEATN 2178
Query: 1004 --QETSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEINS-ETADVVWERDGE-II 1056
+T V +P I +L V E ++ L E + +++W++ G ++
Sbjct: 2179 VAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRL 1113
+ G R+L I D YSC+ + + TA+ V + P I
Sbjct: 2239 TDSMGRVRILSGG--RQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSG 2296
Query: 1114 QNQK---VNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
+ V +G + E E+ V W KDG + + +++ +G +LK +
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLK--NIH 2354
Query: 1170 LDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D G Y C N K + PSI R PE I V LT E
Sbjct: 2355 VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIP 2414
Query: 1225 L-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK-STTKLKVE 1282
L +TW+K + + ++S R L + + T +D +YTCV+ +A K+
Sbjct: 2415 LPSITWFKDGWPVSLSNSVRILSG--GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 1283 VVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V PP IV + ++K VTL + P P W + + ++ + I S
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ--EDEAHHIIS 2530
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSS 1395
L I V+ G Y + GH ++ + P+ G P + + +
Sbjct: 2531 GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 1396 SINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
S E + +TI ++ + +++ I + +T I N + +++ R+ A
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-KDGTPLESNRNIRILPGGRT-LQILNAQEDNAGRYSCVA 2648
Query: 1456 VNEV-DISDASETTEYY-KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
NE ++ E Y +I + + P + K + + N + L C +P +
Sbjct: 2649 TNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSP--KEVKIKVNNTLTLECEAYAIPSASL 2706
Query: 1514 TWYRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+WY+DG+ LK+ N Y C+A N GE E V IQ P
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Query: 1572 ----VITISNE-DIKQKHKVGDEWLVTAV-----IEGIPPPEVIWYKNGNKLENDKEYNI 1621
+ I N D + + D + + PPP + WYK+G+ L + + I
Sbjct: 2767 SFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLI 2826
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ V++I K + +YT A N AG S++ ++V P
Sbjct: 2827 LPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Score = 176 bits (429), Expect = 6e-43
Identities = 262/1150 (22%), Positives = 439/1150 (38%), Gaps = 122/1150 (10%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLV 658
+ A +SD G T D+ +PP + + V + L C+
Sbjct: 2070 LTSAQISDTG-RYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSD 2128
Query: 659 AIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE 718
AIP P + WL G ++ +S++ SVLKI + + G YT A N G+
Sbjct: 2129 AIPPPTLTWLKDGHPLLKKPGLSISENR------SVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 719 ASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
+ I PP + + L + V +G + L + G P P + W K PV
Sbjct: 2183 TEKNYNVNIWV----PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL 2238
Query: 777 A-----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE-EPTEENA 830
+ S G I+I + D +Y+ A N G A+ + V PT N+
Sbjct: 2239 TDSMGRVRILSGGRQLQISIAEK---SDAALYSCVASNVAGTAKKEYNLQVYIRPTITNS 2295
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
+ EI V +I L V P P++TW ++ + ++ + +G ++L
Sbjct: 2296 G-----SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQL 2350
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQ-KSYETEEGKTVILE 949
+V D+G Y CVA N AG + +++ H ++ E +V L
Sbjct: 2351 KNIHVS---DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 950 CQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--E 1005
C+ S S W+ + +S + I+ GR D G C+V++ E
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNSVRILSGGR--MLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 1006 TSTMLVVKETIPEFI---RKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKN 1061
+ + +P I L+D +VKEK L E+ + ++ W +DG+ ++ +
Sbjct: 2466 ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDE 2524
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELP----------P 1107
+ G R L I N V G Y+C+ +S + + V P P
Sbjct: 2525 AHHIISGG--RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNP 2582
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
E +T + N + +A + A + WFKDG+ ++ + +I++ G+ L+I +
Sbjct: 2583 EDVTVILNSPTSLVCEA-----YSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2635
Query: 1168 CDLDDAGEYSCEVGNSKCTAILTVE-----EPSIN----FTLRL-PEFILVPANTDAYLT 1217
D+AG YSC N I E P IN + L P+ + + N L
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2695
Query: 1218 VE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E IP +L +WYK ++ + + ++ TL I++ D YTCV +
Sbjct: 2696 CEAYAIPSASL--SWYKDGQPLKSDDHVNIAAN--GHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 1275 STTKLKVEV-VEFPP---------KIVDYEREYRIKR---GSDVTLLVDYQAFPQPNDEW 1321
+L +V ++ PP ++D R K + ++L + A P P W
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K I L I + + DAG Y N G ++ +V +L P
Sbjct: 2812 YKDGHPL--TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP 2869
Query: 1382 SPPGKPNILE------IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK 1435
G + L ++ S++ C ++ E D +++S I +
Sbjct: 2870 IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQ 2929
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
I N + R+ A N A +Y+ + + + +N+T
Sbjct: 2930 ----ILNTQITDIGRYVCVAEN-----TAGSAKKYFNL--NVHVPPSVIGPKSENLTVVV 2978
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
N I LTC G P P ++W ++ + KL T Y CIA
Sbjct: 2979 NNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGN 1611
N GE + + + P I + + V + V+ E +PPP + WYKNG
Sbjct: 3039 NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGR 3098
Query: 1612 KLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS--KP 1669
+ I + ++ IK+ + S + +Y A N AG L VY PS P
Sbjct: 3099 MITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGP 3156
Query: 1670 EGPVIMREIS 1679
E VI+ IS
Sbjct: 3157 EREVIVETIS 3166
Score = 173 bits (422), Expect = 4e-42
Identities = 232/1115 (20%), Positives = 425/1115 (38%), Gaps = 83/1115 (7%)
Query: 594 STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL 653
S L +E G E T ++ + PT + EG + L
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTL 1000
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C+ P+P + W KGE ++ + + +D +Y + + + G Y A
Sbjct: 1001 PCKASGNPKPSVIWSKKGE-LISTSSAKFSAGADGSLY-----VVSPGGEESGEYVCTAT 1054
Query: 714 NREGEASLPIVLKIKT-----GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
N G A + L + G++ +P++ ++ GE V L +V P P ITW
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITW 1113
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
K + + + + + D G+Y A N G + + V P +
Sbjct: 1114 AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNFDGEN 887
P + ++ V ++ I A+ T P+P ITW + ++ E N DG
Sbjct: 1174 QRGP-----KHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHHVSNPDGT- 1225
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE-----E 942
L I D+G Y CVA+N AG +T+ V++ V+ L+ Y T
Sbjct: 1226 --LSIDQATPS-DAGIYTCVATNIAGTDE--TEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 943 GKTVILECQTSHTV--STKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ + C T + KW HN +E++G + I+++G D G C
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG--TLLVIASVTPYDNGEYIC 1338
Query: 1000 IVKDQETST--MLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVV-WERDG 1053
+ ++ +T +K +P I+ ++ + V + L E+ + ++ W +D
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ + + G I KL+ + D G YSC + + T++ V +PP II
Sbjct: 1399 VQVT-ESSTIQTVNNGKILKLF--RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 1111 -TRLQNQ-KVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T N+ V E ++ KG + WFKDG + F + + + Q L +
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLK 1513
Query: 1167 DCDLDDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
+ +D G Y C V N+ LT+ P + I V N+ L E
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 1223 ETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ +TWYK I + + I K + L I + D YTC + + T +
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Query: 1282 EVVEFPPKIVDYEREYRIKR----GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V + P +++ + + +TL P P W+ + +K + +
Sbjct: 1632 HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-- 1689
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
I++ L I + D G Y + G +++ V +L P+ G
Sbjct: 1690 IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 1398 NICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
N+ + TG+ I ++ + Q ID + + + + I + +++ +R A
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYRCMAA 1808
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTW 1515
N ++ K + T PT++ L + + L CI G+P P +TW
Sbjct: 1809 NTAG--------DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW 1860
Query: 1516 YRDGKKLKTAKATYENRXX---XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+D + + TA+ + + Y C+A N GE + + + + P
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
+ + + + + V + + G P P + WYK+ L ++T + +I I
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGST--SMTFLNRGQIIDI 1978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+ + S + Y A N+AG + + +L+V+ PS
Sbjct: 1979 ESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 173 bits (421), Expect = 6e-42
Identities = 252/1208 (20%), Positives = 458/1208 (37%), Gaps = 111/1208 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S C+ YP ITWF+ ++ +++ ++ TL I ++AG ++CV
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PGGRTLQILNAQEDNAGRYSCV 2647
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG E+ V P + ++ P S PK
Sbjct: 2648 ATNEAGEMIKHYEVKVYIPPIINKGDLW--------------------GPGLS--PKEVK 2685
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+ + + LEC AIP ++W G+ + D+++++A L+I +
Sbjct: 2686 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH------TLQIKEAQISD 2739
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP--QVIEPLKSMIV--RQGES--------V 752
G YT VA N GE L + I+ PP Q + + +M+ R GE+ +
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNIQV----PPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2795
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L + P PT+TW K+ P+ + + + KV+D G YT A N G
Sbjct: 2796 SLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Query: 813 IAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ V P N++ P +E+TV + + + +P P +W ++
Sbjct: 2856 EDSLQYDVRVLVPPIIKGANSDLP------EEVTVLVNKSALIECLSSGSPAPRNSWQKD 2909
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + + +G ++++ T + D G Y CVA N+AG + + + V +
Sbjct: 2910 GQPLLEDDHHKFLSNGRILQILNTQIT---DIGRYVCVAENTAGSAKKYFNLNVHVPP-S 2965
Query: 930 FVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ ++ + L C+ S W N++ I + I+ GR
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 988 XXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR-----KLQDFEVKEKDVAILEVEI 1040
D G CI +Q E+ + +P I+ L V+E LE E
Sbjct: 3026 KVS--DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES 3083
Query: 1041 NSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
N+ V+ W ++G +I + E + L+I+ V D G+Y C + + +
Sbjct: 3084 NAVPPPVITWYKNGRMITESTH---VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDD 3140
Query: 1100 VTV---VELPPEIITRLQNQKVNK-GNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQL 1154
V +PP I + V N T + T + W K+ I+ S+ +++
Sbjct: 3141 KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEV 3200
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPA 1210
I KL+I D+G Y+C N + A L+++ P +P + V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLL 3260
Query: 1211 NTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ L T + W K I E + TL I D +YTCV
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--PQPNDEWIVNS 1325
+ + + V P + + ++ D ++ ++ +A P P W+ N
Sbjct: 3321 ATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP- 1384
+ H + + + + I + + +D +Y N G + N+ + P+
Sbjct: 3381 LPLPLSSHIR--LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDN 3438
Query: 1385 --GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
G I + SS ++ S + ++ + Q + ++V +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMV-LQLLK 3495
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYY--KVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+T S ++ A NE A E ++++ KV++ I + + I P +E
Sbjct: 3496 AETEDSGKYTCIASNE-----AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP---LE 3547
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
LTCI G+P PK+TW +DG+ L T Y C+A + G+
Sbjct: 3548 LTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGD 3607
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ +V + P I ++E + + + +PPP + W +NG +L+
Sbjct: 3608 DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR 3667
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI 1678
I + + ++I ++ YT ASN AG ++ E L V P+ GP + +
Sbjct: 3668 VRILSGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVIL 3725
Query: 1679 SRESVTIE 1686
+S +E
Sbjct: 3726 LNKSTVLE 3733
Score = 165 bits (402), Expect = 1e-39
Identities = 238/1078 (22%), Positives = 414/1078 (38%), Gaps = 81/1078 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 847
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 906
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 962
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 1015 SKKGELISTSSAKFSAGADG---SLYVVSPGGE-ESGEYVCTATNTAGYAKRKVQLTVYV 1070
Query: 926 EKVTF--VKHLQKSYETE----EGKTVILECQTSHTVS--TKWYHNKKEISGMDHREIIQ 977
F + L + E G+ V L C+ W + IS R
Sbjct: 1071 RPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL 1130
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVA 1034
D G+ C+ + + VK + P+ R + +V+
Sbjct: 1131 P--SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ V+ W + G + + G L I + D G Y+C+ +
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATN 1245
Query: 1094 ESCTAEV----------TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ T E TV +L P T Q + N+ + + T ++W +G
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KPTIKWLHNG 1304
Query: 1144 SEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
E+ I + DG L I D GEY C E G ++ L V P +
Sbjct: 1305 RELTGREPGISILEDG--TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIK 1362
Query: 1199 TLRLPEFILVPAN--TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIR 1256
+ V N T+ + VE + + WYK ++ TE T+ + + L +
Sbjct: 1363 DKEQVTNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDN--VQVTESSTIQTVNNGKILKLF 1419
Query: 1257 KCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQA 1313
+ T +D Y+C ++ T++ + V PP I+ ++ E + DV L +
Sbjct: 1420 RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKG 1479
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P P+ W + K + +D + L +K D G Y+ + N G ++
Sbjct: 1480 TPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDI 1538
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+TI PS G +I ++ E E G I + + Q I ++
Sbjct: 1539 KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS--QALY 1596
Query: 1433 ITKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
I K Q I + + S + + N ++ +E + + V I+ + PL N
Sbjct: 1597 IDKGQYLHIPRAQVSDSATYTCHVAN---VAGTAEKSFHVDVYVPPMIEG-NLATPL-NK 1651
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYK 1549
+ L C G P P +TW +DG +K Y
Sbjct: 1652 QVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYI 1711
Query: 1550 CIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
C+A + GE E V + P I +E V + + + G PPP ++W K+
Sbjct: 1712 CVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD 1771
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
G ++ + I + V I + + S++ Y A+NTAG E + V+ P+
Sbjct: 1772 GQLIDERDGFKILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 164 bits (399), Expect = 3e-39
Identities = 241/1072 (22%), Positives = 409/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 3301
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M +
Sbjct: 3302 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD- 3357
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 3358 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 3418 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 3473 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 3524
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3584
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 3585 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3699
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 3700 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 3757
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 3758 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 3813
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 3814 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3871
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 3872 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3931
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 3932 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 3989
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 3990 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 4040
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 4098
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 4159 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 4214
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 4215 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4266
Score = 160 bits (389), Expect = 4e-38
Identities = 222/1029 (21%), Positives = 397/1029 (38%), Gaps = 84/1029 (8%)
Query: 680 ISVAIESDMHMYCSV-LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+++ ++ + SV L I V EG Y +AV+ G + EPP VI
Sbjct: 468 VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS----EPPPVI 523
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKV 797
+ ++ V GE +L+ ++ +TW +N++ V+ A P + + LK K
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF 583
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y + G + S +TV+EP + P + Q T + + ++ T
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP-----KNQSFTGGSE--VSIMCSAT 636
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P I W N+ I S DG L I N + D+G Y C+ASNSAG
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG---TLFIKNAAPK-DAGIYGCLASNSAGTDKQ 692
Query: 918 GARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHRE 974
+ + I+ K+ V Q G ++EC+TS KW+ E+
Sbjct: 693 NSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF-- 747
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+I + D G C+ ++ T + + + P FI++ D ++
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807
Query: 1032 DVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
L + + W R D I + + L+I N D+G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 1090 ILRDE--SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDALV--RWFKD 1142
++ +E TV + P I V +G + T L G+ + RW K+
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-----NSKCTAILTVEEPSIN 1197
+ + + +I + DG L I L D GEY+C N+K T+++ P+I
Sbjct: 928 SAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 1198 FTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLII 1255
++ I +P + + V W KK +I + KF+ +D +L +
Sbjct: 985 HGQQILSTIEGIPVTLPCKAS---GNPKPSVIWSKKGELISTSSAKFSAGAD---GSLYV 1038
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER--------EYRIKRGSDVT 1306
++ EY C + K KV++ V P++ +R E + G +VT
Sbjct: 1039 VSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
L + ++ P P W +++I + S S+ I + +D+G+Y N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKITETRTSDSGMYLCVATNIA 1156
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G+ + + + P P L++ + D P N + + V+ + + +T
Sbjct: 1157 GNVTQAVKLNVHVPPKIQRGPKHLKV---QVGQRVDIPCNAQGTPL--PVITWSKGGSTM 1211
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE- 1485
+ ++ ++ + Y +I+ E TE ++E PTVE
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE-TEITLHVQE----PPTVED 1266
Query: 1486 -KPLKNITTE---PNEDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXX 1538
+P N T + N+ IE C G P+P + W +G++L + + E+
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIA 1326
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N+ G E + + PVI + + + +EG
Sbjct: 1327 SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P ++WYK + ++ + I T ++++ + +Y+ +A N AGTS
Sbjct: 1387 TPSPIIMWYK--DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 1659 TLKVYDKPS 1667
+ V P+
Sbjct: 1445 NIDVLVPPT 1453
Score = 151 bits (367), Expect = 2e-35
Identities = 241/1167 (20%), Positives = 421/1167 (36%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 3506
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 3561
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 3562 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 3592
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 3593 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 3647
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 3648 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 3708 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 3760
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 3761 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 3817
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 3878 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 3937
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 3938 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3994
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4050
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 4106
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S +L I D YTC+ + S+T K
Sbjct: 4107 PPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4162
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 4163 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 4218
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 4219 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 4267
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 4268 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4324
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K I ++ P V K + EP + L C G P P + W
Sbjct: 4325 TYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN 4384
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 4445 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 4499
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 4500 QKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 149 bits (362), Expect = 8e-35
Identities = 233/1097 (21%), Positives = 389/1097 (35%), Gaps = 84/1097 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + PK Q GS++ + C P+P IAW IV + SD
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT--SD----- 663
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N G Y +A N G L+ E P+++ ++V G+
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRY----IEAPKLMVVQSELLVALGDIT 719
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G P P + W K + ++ + ++ + D G YT A N G
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NN 870
A + V PP+FI +++++ + L V P P+I W R N
Sbjct: 780 RATGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I S +++ L I N+ + D G Y C A N GK VT+
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ EG+ + L C + +W N + + + +G
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
+ + V T VV +P Q E L + + +
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPS 1011
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
V+W + GE+I K+ G LY+ + + GEY C + + A+ V V
Sbjct: 1012 VIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 1104 ELPPEII---TRLQNQK-----VNKGNKATFEIEL-TKGDALVRWFKDGSEIQ-FSNHIQ 1153
+ P + L K V G + T E+ + ++ W K+ I FS
Sbjct: 1069 YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHT 1128
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
G +KI + D+G Y C GN L V P R P+ + V
Sbjct: 1129 FLPSG---SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP--KIQRGPKHLKVQ 1183
Query: 1210 ANTDAYLTVEIPDETLDV-TWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L V TW K S ++ D E D TL I + T D YT
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATPSDAGIYT 1240
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIK-----RGSDVTLLVDYQAFPQPNDEW 1321
CV + T + ++ + V+ PP + D E Y + + P+P +W
Sbjct: 1241 CVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW 1300
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ N + + + SI L I V D G Y N G + + N+ + P
Sbjct: 1301 LHNGRELTG-REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Query: 1382 SPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
K + + + + + E E T + I++Y + TE +++ + +
Sbjct: 1360 VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWY---KDNVQVTESSTIQTVNNGK-- 1414
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN-ITTEPNED 1498
I L + Y+ ++I+ S+ +Y+ + + + + N ++ N D
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQ--KYFNI--DVLVPPTIIGTNFPNEVSVVLNRD 1470
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCIAFND 1555
+ L C G P P + W++DGK L E Y+C N
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G+ + I P I N + + G+P P + WYK+G + +
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG---- 1671
+ +K + I + S S+ YT +N AGT+ + VY P EG
Sbjct: 1591 SSQ--ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY-VPPMIEGNLAT 1647
Query: 1672 PVIMREISRESVTIEWK 1688
P+ + + S+T+E K
Sbjct: 1648 PLNKQVVIAHSLTLECK 1664
Score = 147 bits (356), Expect = 4e-34
Identities = 238/1118 (21%), Positives = 422/1118 (37%), Gaps = 93/1118 (8%)
Query: 599 IVEAPLSDHGS-EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
I + LSD G E D+ E PP + P V G +L C +
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
++ + ++ W ++ E + +++ L++ +VK G Y + + G
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-----LELKSVKFNDAGEYHCMVSSEGG 598
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA 777
++ + L + +EPP+V K+ G V + G P+P I W N+ +
Sbjct: 599 SSAASVFLTV----QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 778 LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-AETSAVITVEEPTEENAEPPLFI 836
+ + +K KD G+Y A NS G + S + +E P + L +
Sbjct: 655 -SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLV 713
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
+ITV E + + P P + W++ + + PS + + + L+
Sbjct: 714 -ALGDITVME-------CKTSGIPPPQVKWFKGDLELRPSTFLIID---PLLGLLKIQET 762
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSH 954
++D+GDY CVA N AG+++ ++T+DV E G V L C Q
Sbjct: 763 QDLDAGDYTCVAINEAGRAT--GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Query: 955 TVSTKW--YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETST 1008
+ KW N S I + R D G C ++Q ++ T
Sbjct: 821 EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 1009 MLVVKETIPEFIRKLQDF-EVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDF 1065
+ V + I V E L + + + W ++ ++ +N Y
Sbjct: 881 TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML--LQNPYIT 938
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITRLQNQKVNKGN 1122
+ L+I + D GEY+C+ + + T T VV + P I Q +G
Sbjct: 939 VRSD--GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + V W K G I S+ DG L + +++GEY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVCTA 1053
Query: 1179 --EVGNSKCTAILTV-EEPSI-----NFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTW 1229
G +K LTV P + + P I V A + L E+ +TW
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 1230 YKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
K+ +I + + T + ++ I + D Y CV + V++ V P
Sbjct: 1114 AKETQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLT 1346
PKI + +++ G V + + Q P P W S ++ +H + + +L+
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEH---HVSNPDGTLS 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSSSINICW 1401
I + +DAGIY N G + E+ + + + P+ PP E ++ I +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-RIEF 1286
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
P I ++ +E+ E IS+ T I ++ + + AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILE-DGTLLVIASVTPYDNGEYICVAVNE-- 1343
Query: 1461 ISDASETTEYYKVIKETKIQSPTV---EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
A T Y + K+ P V ++ + N++ N+ L C G P P + WY+
Sbjct: 1344 ---AGTTERKYNL----KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Query: 1518 DGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
D ++ + T N Y C A N G + + + P I
Sbjct: 1397 DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
+N + + + + ++G P P++ W+K+G L + N+ ++ V+ +K
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
+R+ +Y SN AG + ++ L +Y PS G V
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553
Score = 121 bits (291), Expect = 3e-26
Identities = 205/965 (21%), Positives = 343/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 3618 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 3674
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 3675 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 3727
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 3728 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 3787
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 3788 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 3898
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 3899 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 3958 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4017
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 4018 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 4074
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 4075 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 4131
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 4132 S---LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 4185
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 4242
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 4243 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 4302
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P +
Sbjct: 4303 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP-------VF 4351
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ D S W EP G + I+ V+ T +W + I+ L S
Sbjct: 4352 KGDYPS---NWIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS--- 4403
Query: 1451 FRAYAVNEVDISD-ASETTEYYKVIKET---KIQSPTV--EKPLKNITTEPNEDIELTCI 1504
Y D D T V++ + +QSP + +P++ + + I L C
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK-IILNCQ 4462
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 4463 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4522
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 4523 PVIVQ 4527
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C GYP+P+I W I S ++M D TL I+ P+DAG + C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD----GTLFIKNAAPKDAGIYGC 681
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+A N+AG + L +EAP
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP 702
Score = 51.6 bits (118), Expect = 3e-05
Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V EC+ P P ITW++ +I S ++ D L I++
Sbjct: 3064 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 3120
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 3179
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 3180 PPTIAWLKNHKRIENSD-SLEVRILS 3204
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 773 VAINEAGRATGKITLDVGSP 792
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 489 NEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
++K ++ V PT + ++ V K +P V +C G P P ITW +
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKP--------VALQCIANGIPNPSITWLKDDQ 1865
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +Q V L I + EDAG +TCVA NAAG +L V P S
Sbjct: 1866 PVNTAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 4313
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF + + V+ P
Sbjct: 4314 VIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Score = 47.2 bits (107), Expect = 6e-04
Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 1658
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC+ G P P +TW + +K + + ++ + + +E+ D G + CVA
Sbjct: 1659 LTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT 1715
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q +
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI 1775
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVS 1798
Score = 47.2 bits (107), Expect = 6e-04
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G C+V+G P P I W R+ I+ S + + +L I EDAG +
Sbjct: 4362 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVNEDAGDY 4417
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA N AG + L +++P
Sbjct: 4418 TCVATNEAGVVERSMSLTLQSP 4439
Score = 45.6 bits (103), Expect = 0.002
Identities = 38/185 (20%), Positives = 69/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ V +++ PV + +G ++ ++G P
Sbjct: 4320 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFK-GDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 4379 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 1662 VYDKP 1666
+ P
Sbjct: 4436 LQSPP 4440
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 4239 CVANNAAGEDTHTVSLTV 4256
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 4044
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 4045 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 4454 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 4509
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 4510 VARNLMGSVLVRVPVIVQ 4527
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 3910 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 3962
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 3963 GRYTCVARNAAGSAHRHVTLHVHEP 3987
>AF156100-1|AAK68690.1| 5636|Homo sapiens hemicentin protein.
Length = 5636
Score = 233 bits (571), Expect = 4e-60
Identities = 291/1201 (24%), Positives = 479/1201 (39%), Gaps = 129/1201 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ EC+V+G P P +TW + + ++ ++ D+ ++ L ++ + D G + C
Sbjct: 2308 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHI--LQLKNIHVSDTGRYVC 2364
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA N AG +L V AP S G+ + P S
Sbjct: 2365 VAVNVAGMTDKKYDLSVHAPPSIIGNHRS--------------------PENIS------ 2398
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V E + + L C IP P W FK V N SV I S M L++
Sbjct: 2399 -VVEKNSVSLTCEASGIPLPSTTW-FKDGWPVSLSN-SVRILSGGRM----LRLMQTTME 2451
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGN 761
G YT V N GE L + PP ++ L+ + V++ +SV L+ +V GN
Sbjct: 2452 DAGQYTCVVRNAAGEERKIFGLSVLV----PPHIVGENTLEDVKVKEKQSVTLTCEVTGN 2507
Query: 762 PRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P ITW K+ +P+ +A S G IT + +V G YT A + G S
Sbjct: 2508 PVPEITWHKDGQPLQEDEAHHIISGGRFLQITNV---QVPHTGRYTCLASSPAGHKSRSF 2564
Query: 819 VITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+ V PT +++TV LV P +ITW+++ + +
Sbjct: 2565 SLNVFVSPTIAGVGSD---GNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNR 2621
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL--- 934
I G ++++ D ++G Y CVA+N AG+ V + + + L
Sbjct: 2622 NIRILPGGRTLQILNAQED---NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGP 2678
Query: 935 ---QKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
K + + T+ LEC+ + S WY + + + DH I G
Sbjct: 2679 GLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEA 2736
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIRKLQDF--------EVKEKDVAI---- 1035
D G C+ + E V +P +KL + + KDV I
Sbjct: 2737 QISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2796
Query: 1036 -LEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L E N + + W +DG + +K G R L I V D G Y+C+ +
Sbjct: 2797 SLYCETNAAPPPTLTWYKDGHPL-TSSDKVLILPGG--RVLQIPRAKVEDAGRYTCVAVN 2853
Query: 1094 ES--CTAEVTVVELPPEII----TRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSE 1145
E+ + + V L P II + L + NK+ L+ G R W KDG
Sbjct: 2854 EAGEDSLQYDVRVLVPPIIEGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQP 2913
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLR 1201
+ +H + +G+ L+I + + D G Y C G++K L V P +
Sbjct: 2914 LLEDDHHKFLSNGR--ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK 2971
Query: 1202 LPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E + V N LT E+ D++W K I+ ++ RTL I +
Sbjct: 2972 -SENLTVVVNNFISLTCEVSGFPPPDLSWLKNXQPIKLNTNTLIVPG--GRTLQIIRAKV 3028
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE----YRIKRGSDVTLLVDYQAFP 1315
D EYTC+ ++ +K K + V PP I D++ E ++ G+ V+L + A P
Sbjct: 3029 SDGGEYTCIAINXAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3088
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W N ++I + H + D + L IKK E +D G Y R N G D ++
Sbjct: 3089 PPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSDTGQYVCRAINVAGRDDKNFHL 3146
Query: 1376 TILDKPS--PPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKN 1432
+ PS P + I+E S+ + + D TG I ++ Y+ I+ ++ + V+
Sbjct: 3147 NVYVPPSIEGPEREVIVETISNPVTLTCDA---TGIPPPTIAWLKNYKRIENSDSLEVRI 3203
Query: 1433 IT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
++ ++ I + + S + A N + +YY + + E P ++
Sbjct: 3204 LSGGSKLQIARSQHSDSGNYTCIASNM-----EGKAQKYYFLSIQVPPSVAGAEIP-SDV 3257
Query: 1492 TTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXXXXXXXX 1547
+ E++EL C G+P P + W +DGK + + + N
Sbjct: 3258 SVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3317
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL-VTAVIEGIPPPEVIW 1606
Y C+A N GE + + + P I + ++ ++ D + + G PPP++ W
Sbjct: 3318 YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTYVDTSINIECRXTGTPPPQINW 3377
Query: 1607 YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
KNG L + + VIRI + S + YT ASN AG + L+V+ P
Sbjct: 3378 LKNGLPLPLSSHIRLLAAGQ--VIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPP 3435
Query: 1667 S 1667
+
Sbjct: 3436 N 3436
Score = 217 bits (531), Expect = 3e-55
Identities = 277/1202 (23%), Positives = 470/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 1027
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G
Sbjct: 1028 FSAGADGSLYVVSPEGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGD---------- 1077
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
L G+ KP V G ++ L C + ++P P I W + + I P
Sbjct: 1078 ---------LRGLS---QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 1125
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA N G + + L + PP++
Sbjct: 1126 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV----PPKIQR 1175
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 1235
Query: 800 EGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+E PT E+ EPP + FQE ++ A+ T
Sbjct: 1236 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 1293
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + E LVI +V + D+G+Y CVA N AG +
Sbjct: 1294 -PKPTIKWLHNGRELTGREPGISILE-EGTLLVIASV-TPYDNGEYICVAVNEAGTTERK 1350
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 1351 YNLKVHVPPVIKDKEQVSNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 1410
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTM-----LVVKETIPEFIRKLQDFEVKE 1030
G+ D G C + TS ++V TI + V
Sbjct: 1411 NNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPKEVSVVLN 1468
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ + D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 1469 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 1525
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 1526 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECKTRGLPMPAITWYKDG 1585
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 1586 QPIMSSSQ-ALYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 1638
Query: 1204 EFI----LVPANTDAY----LTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + F + + KK
Sbjct: 1639 PMIEGNLATPLNKQVVIAHSLTLECNAAGNPSPILTWLKDGVPVKANDNFRIEAGGKK-- 1696
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLV 1309
L I E D+ +Y CV ++K EV V PP I D + + + + L
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + ++I + K ++ + + +V NT G+Y+ N G
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 1814
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 1815 KKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQ--- 1871
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 1872 -GNL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 1926
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR-XXXXXXXXXXXXX 1545
N T + ++L C G P P +TWY+D L + T+ NR
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNCLLSGSTSMTFLNRGQIIDIESAQISDA 1986
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV--VVNNPVRLECEARGIPAPSLT 2044
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 2045 WLKDGSPVSSFSN-GLQVLSGGRILALTSTQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 1666 PS 1667
P+
Sbjct: 2104 PN 2105
Score = 206 bits (502), Expect = 9e-52
Identities = 275/1181 (23%), Positives = 459/1181 (38%), Gaps = 96/1181 (8%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 1233
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 1234 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTV------------EDLEPPYNTT 1274
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE-NISVAIESDMHMYCSV 694
F ++ Q ++ C P+P I WL G E+ E IS+ E ++
Sbjct: 1275 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREPGISILEEG------TL 1322
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESV 752
L I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 1323 LVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVSNVSVLLNQLT 1378
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 1379 NLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAG 1438
Query: 813 IAETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
++ I V P P + F +E++V + L +V P P I W+++ +
Sbjct: 1439 TSQKYFNIDVLVP------PTIIGTNFPKEVSVVLNRDVALECQVKGTPFPDIHWFKDGK 1492
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV 931
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 1493 PLFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKG 1550
Query: 932 KHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
++ + LEC+T + WY + + I I +G+
Sbjct: 1551 GNVTTDISVLINSLIKLECKTRGLPMPAITWYKDGQPIMSSSQALYIDKGQ--YLHIPRA 1608
Query: 990 XXXDVGVIKCIVKD--QETSTMLVVKETIPEFIR-KLQDFEVKEKDVA-ILEVEIN---S 1042
D C V + V +P I L K+ +A L +E N +
Sbjct: 1609 QVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECNAAGN 1668
Query: 1043 ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
+ + W +DG +K N + E G +KL I + D G+Y C+ + E+
Sbjct: 1669 PSPILTWLKDGVPVKANDN-FRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKY 1725
Query: 1103 ---VELPPEIITRLQNQK--VNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTI 1156
V +PP I + V N + +T + W KDG I + ++ +
Sbjct: 1726 EVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILL 1785
Query: 1157 DGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFILVPANT 1212
+G+ KL I + + G Y C G+ K +TV P + L E ++V
Sbjct: 1786 NGR--KLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKP 1843
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
A + +TW K + +T + L R L I K +D YTCV +
Sbjct: 1844 VALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATN 1902
Query: 1273 AKSTTKLKVEV-VEFPPKIVDYER--EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIK 1329
A T+ +++ V PP + D + + + V L P P W ++ ++
Sbjct: 1903 AAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNCLLS 1962
Query: 1330 KCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI 1389
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N+
Sbjct: 1963 --GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNM 2020
Query: 1390 LEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+ + ++ E ++ + + + V + + ++ + + + +
Sbjct: 2021 VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSTQISDTG 2079
Query: 1450 RFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVP 1509
R+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 2080 RYTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIP 2131
Query: 1510 QPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE-TSCVVG 1566
P +TW +DG L K + ENR Y C A N G+ E + V
Sbjct: 2132 PPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKKNYNVN 2191
Query: 1567 IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEK 1626
I P I S+E + G+ + GIPPP +IW K G+ + D +
Sbjct: 2192 IWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSG 2251
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++I ++S ++ Y+ ASN AGT+ E L+VY +P+
Sbjct: 2252 GRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPT 2292
Score = 196 bits (478), Expect = 7e-49
Identities = 249/1089 (22%), Positives = 428/1089 (39%), Gaps = 93/1089 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+ S V + + LEC IP P + WL G + N +
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
+L +T+ + G YT VAVN GE I L++ PP ++ +++ V ++
Sbjct: 2067 --ILALTSTQISDTGRYTCVAVNAAGEKQRDIDLRVYV----PPNIMGEEQNVSVLISQA 2120
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
V L Q P PT+TW K+ P+ P S + S+ ++ +V+D G YT +A N
Sbjct: 2121 VELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 812 GIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YRN 869
G E + + P L ++TV E I L+ + P P++ W +
Sbjct: 2181 GKTEKKNYNVNIWVPPNIGGSDEL-----TQLTVIEGNLISLLCESSGIPPPNLIWKKKG 2235
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEK 927
+ +++ S + G +L I ++ + D+ Y CVASN AG K + +V I
Sbjct: 2236 SPVLTDSMGRVRILSGGR-QLQI-SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTI 2293
Query: 928 VTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
H + T GK++ LEC+ + W + + EI+ EG
Sbjct: 2294 TNSGSHPTEIIVT-RGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQ 2350
Query: 986 XXXXXXXDVGVIKCI------VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVE 1039
D G C+ + D++ + +I R ++ V EK+ L E
Sbjct: 2351 LKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCE 2410
Query: 1040 INS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ES 1095
+ W +DG + N G R L + T++ D G+Y+C++R+ E
Sbjct: 2411 ASGIPLPSTTWFKDGWPVS-LSNSVRILSGG--RMLRLMQTTMEDAGQYTCVVRNAAGEE 2467
Query: 1096 CTAEVTVVELPPEII--TRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHI 1152
V +PP I+ L++ KV + T E+T + W KDG +Q
Sbjct: 2468 RKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAH 2527
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSIN--FTLRLPEF 1205
+ G+ L+I + + G Y+C + S+ ++ P+I + PE
Sbjct: 2528 HIISGGR--FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPED 2585
Query: 1206 ILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQC 1264
+ V N+ L E +TW+K + +E ++ RTL I ED+
Sbjct: 2586 VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG--GRTLQILNAQEDNAG 2643
Query: 1265 EYTCVLLDAKSTTKLKVEVVEFPPKIVD---------YEREYRIKRGSDVTLLVDYQAFP 1315
Y+CV + EV + P I++ +E +IK + +TL + A P
Sbjct: 2644 RYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIP 2703
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
+ W + + +K H +I + +L IK+ + +D G Y N G +++ +V
Sbjct: 2704 SASLSWYKDGQPLKSDDHV--NIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDV 2761
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWDEPENT--GNSTIIYYVVEYQEIDTTEWISVKN- 1432
I PP + EI + E ++ N +Y T W +
Sbjct: 2762 NI---QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHP 2818
Query: 1433 ITKTQ----------TSIQNLKTNSSYRFRAYAVNEVDISDASETTEY-YKVIKETKIQS 1481
+T + I K + R+ AVNE ++ +Y +V+ I+
Sbjct: 2819 LTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA----GEDSLQYDVRVLVPPIIEG 2874
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXX 1539
+ P + +T N+ + C+ G P P+ +W +DG+ L N
Sbjct: 2875 ANSDLP-EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILN 2933
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP-VITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N G + + + P VI +E++ V + +T + G
Sbjct: 2934 TQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV--VVNNFISLTCEVSG 2991
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
PPP++ W KN ++ + I +T ++I K S +YT A N AG S +
Sbjct: 2992 FPPPDLSWLKNXQPIKLNTNTLIVPGGRT--LQIIRAKVSDGGEYTCIAINXAGESKKKF 3049
Query: 1659 TLKVYDKPS 1667
+L VY PS
Sbjct: 3050 SLTVYVPPS 3058
Score = 193 bits (471), Expect = 5e-48
Identities = 269/1212 (22%), Positives = 472/1212 (38%), Gaps = 118/1212 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 853 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 890
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 891 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 944
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 945 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 993
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P+ ++ G Y
Sbjct: 994 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPEG-EESGEYV 1050
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P L ++ EI+V + L V P P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDLRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 1110
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 1111 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 1167
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXX 983
V ++ K + + G+ V + C T +K + + E
Sbjct: 1168 HVPPK--IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225
Query: 984 XXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILE 1037
D G+ C+ + ET L V+E P + L+ ++ VA
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQR 1283
Query: 1038 VEI-----NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
+E + + W +G + ++ + G + L I + + +D GEY C+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEEGTL--LVIASVTPYDNGEYICVAV 1341
Query: 1093 DESCTAEVTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSE 1145
+E+ T E V +PP I + Q V N+ E+E T ++ W+KD +
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVSNVSVLLNQLTNLFCEVEGTP-SPIIMWYKDNVQ 1400
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLR 1201
+ S+ IQ +GK LK++ +DAG YSC+ G S+ + V P
Sbjct: 1401 VTESSTIQTVNNGK--ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 1202 LPEFILVPANTDAYLTVEIPDETL-DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P+ + V N D L ++ D+ W+K K + L+ + + L ++
Sbjct: 1459 FPKEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD--RGQVLHLKNAR 1516
Query: 1260 EDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFP 1315
+D+ Y C + +A K +K+ + PP I + + + S + L + P
Sbjct: 1517 RNDKGRYQCTVSNAAGKQAKDIKL-TIYIPPSIKGGNVTTDISVLINSLIKLECKTRGLP 1575
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
P W + + I ID K L I + + +D+ Y + N G A+ +V
Sbjct: 1576 MPAITWYKDGQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVK 1431
+ P G N+ + + I E GN S I+ ++ + + +
Sbjct: 1634 DVYVPPMIEG--NLATPLNKQVVIAHSLTLECNAAGNPSPILTWLKDGVPVKAND----- 1686
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLK 1489
N + + + L+ S+ V S A E Y+V + P +E
Sbjct: 1687 NF-RIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETS 1742
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXX 1547
N +EL C G P P + W +DG+ + + N
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGL 1802
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C+A N G+ + V + P I S +E + K+K + + GIP P +
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSIT 1859
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+ + N + N+ + V++I + + +YT A+N AG + + L V++
Sbjct: 1860 WLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Query: 1666 PSKPEGPVIMRE 1677
PS + ++ E
Sbjct: 1919 PSLEDAGKMLNE 1930
Score = 193 bits (471), Expect = 5e-48
Identities = 268/1219 (21%), Positives = 469/1219 (38%), Gaps = 119/1219 (9%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S ++ EC+ G P P ITW++ I S +Y D + +V D+ T+TC
Sbjct: 1563 SLIKLECKTRGLPMPAITWYKDGQPIMSSSQ-ALYIDKGQYLHIPRAQV--SDSATYTCH 1619
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
N AG A + + V P ++EG T P +
Sbjct: 1620 VANVAGTAEKSFHVDVYVP-----------------------PMIEGNLAT----PLNKQ 1652
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + LEC P P + WL G + ++N + L+I + ++
Sbjct: 1653 VVIAHSLTLECNAAGNPSPILTWLKDGVPVKANDNFRIEAGGKK------LEIMSAQEID 1706
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVILSAQVVGNP 762
G Y VA + GE + K + PP + + IV + L V G+P
Sbjct: 1707 RGQYICVATSVAGEKEI----KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 763 RPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
PTI W K+ + + ++ +V + G+Y A N+ G + +TV
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE-TITQ 881
P P + + E V + + L P PSITW ++++ ++ ++ +
Sbjct: 1823 HVP------PTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-ET 940
G +++ T ++ D+G Y CVA+N+AG++ + + V + ++ K ET
Sbjct: 1877 QSSGRVLQIAKTLLE---DAGRYTCVATNAAGETQQ--HIQLHVHEPPSLEDAGKMLNET 1931
Query: 941 E-EGKTVILECQTS-HTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
V LEC+ + + V WY + +SG + G+ D G+
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNCLLSGSTSMTFLNRGQIIDIESAQIS--DAGIY 1989
Query: 998 KCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDG 1053
KC+ + +T L + P V + LE E A + W +DG
Sbjct: 1990 KCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDG 2049
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ N G I L + +T + D G Y+C+ + + + + V +PP I+
Sbjct: 2050 SPVSSFSNGLQVLSGGRI--LALTSTQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107
Query: 1111 TRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
QN V L + DA+ + W KDG + L+I + LKI
Sbjct: 2108 GEEQNVSVLISQAVEL---LCQSDAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKIE 2162
Query: 1167 DCDLDDAGEYSCEVGN------SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
D + D G Y+CE N K + P+I + L + ++ N + L
Sbjct: 2163 DAQVQDTGRYTCEATNVAGKTEKKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESS 2222
Query: 1221 PDETLDVTWYKKKS-VIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK 1278
++ W KK S V+ D+ + ++S R L I + D Y+CV + T K
Sbjct: 2223 GIPPPNLIWKKKGSPVLTDSMGRVRILSG--GRQLQISIAEKSDAALYSCVASNVAGTAK 2280
Query: 1279 LKVEV-VEFPPKIVD---YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
+ + V P I + + E + RG ++L + Q P P W+ + + K K
Sbjct: 2281 KEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGV 2340
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
+ I + L +K + +D G Y N G D + ++++ PS I+
Sbjct: 2341 E--ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPS------IIGNHR 2392
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAY 1454
S NI E NS + + +T W S++ L R
Sbjct: 2393 SPENISVVEK----NSVSLTCEASGIPLPSTTWFKDGWPVSLSNSVRILSGGRMLRLMQT 2448
Query: 1455 AVNEVDISDA---SETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVP 1509
+ + + E K+ + + P + E L+++ + + + LTC G P
Sbjct: 2449 TMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP 2508
Query: 1510 QPKVTWYRDGKKLKTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
P++TW++DG+ L+ +A + Y C+A + G S + +
Sbjct: 2509 VPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2568
Query: 1568 QQKPVIT-ISNEDIKQKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTK 1624
P I + ++ + V + V E PP + W+K+G LE+++ I
Sbjct: 2569 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2628
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+T ++I + ++ +Y+ A+N AG +KVY P +G + +S + V
Sbjct: 2629 GRT--LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVK 2686
Query: 1685 IEWKPPLDDGGLELTKYAI 1703
I+ L LE YAI
Sbjct: 2687 IKVNNTLT---LECEAYAI 2702
Score = 192 bits (468), Expect = 1e-47
Identities = 244/1089 (22%), Positives = 420/1089 (38%), Gaps = 92/1089 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C + P I W G + + NI + L+I N ++ G Y+ VA
Sbjct: 2596 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGG------RTLQILNAQEDNAGRYSCVA 2649
Query: 713 VNREGEASLPIVLK------IKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
N GE +K I G+ P + P K + ++ ++ L + P ++
Sbjct: 2650 TNEAGEMIKHYEVKVYIPPIINKGDLWGPG-LSP-KEVKIKVNNTLTLECEAYAIPSASL 2707
Query: 767 TWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+W K+ +P+K+ + H++ I K ++ D G YT A N G E + ++ P
Sbjct: 2708 SWYKDGQPLKSDDHVNIAANGHTLQI-KEAQISDTGRYTCVASNIAGEDELDFDVNIQVP 2766
Query: 826 T--EENAEPPLFINRFQEITVKE---KGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
++ E ++ + K+ I L P P++TWY++ ++ S+ +
Sbjct: 2767 PSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVL 2826
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS--HGARVTIDVEKVTFVKHLQKSY 938
G +++ V+ D+G Y CVA N AG+ S + RV + L +
Sbjct: 2827 ILPGGRVLQIPRAKVE---DAGRYTCVAVNEAGEDSLQYDVRVLVPPIIEGANSDLPEEV 2883
Query: 939 ETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
K+ ++EC +S + + + W + + + DH + + GR D+G
Sbjct: 2884 TVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQIT--DIGR 2941
Query: 997 IKCIVKDQETSTMLVVKETI---PEFIR-KLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
C+ ++ S + P I K ++ V + L E++ D+ W +
Sbjct: 2942 YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3001
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD---ESCTAEVTVVELPPE 1108
+ + IK N G R L I V D GEY+CI + ES V +PP
Sbjct: 3002 NXQPIKLNTNTL-IVPGG--RTLQIIRAKVSDGGEYTCIAINXAGESKKKFSLTVYVPPS 3058
Query: 1109 IITR----LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
I L V +G + E E ++ W+K+G I S H+++ DG Q L
Sbjct: 3059 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG--QML 3116
Query: 1164 KIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I ++ D G+Y C N K + PSI R E I+ + LT
Sbjct: 3117 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTC 3174
Query: 1219 E---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
+ IP T + W K IE+++ + L I + D YTC+ + +
Sbjct: 3175 DATGIPPPT--IAWLKNYKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEG 3232
Query: 1276 TT-KLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
K ++ PP + E + + G +V L+ + P P +W+ + K I +
Sbjct: 3233 KAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3292
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN---- 1388
+ + + ++L I +D G Y N G D N+ + P+ G +
Sbjct: 3293 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3352
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
++ +SINI E TG W+ + I+ L
Sbjct: 3353 LMTYVDTSINI---ECRXTGTPP-----------PQINWLKNGLPLPLSSHIRLLAAGQV 3398
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTC 1503
R V++V + + K +Q P ++ + + IT + C
Sbjct: 3399 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3458
Query: 1504 IFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVET 1561
I G P P + W RDG+ L A T Y CIA N+ GEV
Sbjct: 3459 ITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSK 3518
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
++ + + P I S E + V + +T + GIP P++ W K+G L + +
Sbjct: 3519 HFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--V 3576
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREIS 1679
T V+RI + + +YT AS+ AG E ++V+ P + + P + +
Sbjct: 3577 QTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR 3636
Query: 1680 RESVTIEWK 1688
VT+E K
Sbjct: 3637 NRQVTLECK 3645
Score = 182 bits (442), Expect = 2e-44
Identities = 261/1206 (21%), Positives = 455/1206 (37%), Gaps = 135/1206 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
+G+ + C+ G P P + W ++ + ++ S + I E DA +
Sbjct: 2211 EGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE--KSDAALY 2268
Query: 582 TCVAKNAAGFASS--TTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
+CVA N AG A ++ + +++ GS T ++ +GIPP
Sbjct: 2269 SCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV-QGIPP----- 2322
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P ++ +G ++ KG EI+ DE +L++ N
Sbjct: 2323 PTVTWMKDGHPLIKA---------------KGVEIL-DEG-------------HILQLKN 2353
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS---MIVRQGESVILSA 756
+ G Y VAVN G L + PP +I +S + V + SV L+
Sbjct: 2354 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHA----PPSIIGNHRSPENISVVEKNSVSLTC 2409
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ G P P+ TW K+ PV + + L ++D G YT N+ G
Sbjct: 2410 EASGIPLPSTTWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK 2469
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
++V P E N +++ VKEK ++ L VT NPVP ITW+++ + +
Sbjct: 2470 IFGLSVLVPPHIVGE-----NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQED 2524
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E G ++ ITNV +G Y C+AS+ AG S + + V + +
Sbjct: 2525 EAHHIISGGRFLQ--ITNVQVP-HTGRYTCLASSPAGHKSRSFSLNVFVSPT--IAGVGS 2579
Query: 937 SYETEEGKTVILECQTS--------HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
E+ TVIL TS + W+ + + + I+ GR
Sbjct: 2580 DGNPED-VTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR--TLQILN 2636
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRK-------LQDFEVKEK--DVAILE 1037
+ G C+ ++ E VK IP I K L EVK K + LE
Sbjct: 2637 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLE 2696
Query: 1038 VEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
E + +A + W +DG+ +K + + GH L I+ + D G Y+C+ + +
Sbjct: 2697 CEAYAIPSASLSWYKDGQPLK-SDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2753
Query: 1097 TAEVTV---VELPPEI--ITRLQNQKVNKGNKATFEIELTKGDAL-----------VRWF 1140
E+ +++PP + + N N ++ + +L + W+
Sbjct: 2754 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2813
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSI 1196
KDG + S+ + + G+ L+I ++DAG Y+C E G + V P I
Sbjct: 2814 KDGHPLTSSDKVLILPGGR--VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPI 2871
Query: 1197 --NFTLRLPEFILVPANTDAYL-TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
LPE + V N A + + +W K + + + +S+ R L
Sbjct: 2872 IEGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSN--GRIL 2929
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYERE-YRIKRGSDVTLLVDY 1311
I D Y CV + + K + V PP ++ + E + + ++L +
Sbjct: 2930 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEV 2989
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
FP P+ W+ N + IK +T I +L I + + +D G Y N G +
Sbjct: 2990 SGFPPPDLSWLKNXQPIK--LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINXAGESKK 3047
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWIS 1429
+ ++T+ PS I + DS S+++ N T + E + W
Sbjct: 3048 KFSLTVYVPPS------IKDHDSESLSVV-----NVREGTSVSLECESNAVPPPVITWYK 3096
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---SPTVEK 1486
+ T ++ L + V++ + K + P++E
Sbjct: 3097 NGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEG 3156
Query: 1487 PLKNITTEP-NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXXXX 1541
P + + E + + LTC G+P P + W ++ K+++ + +
Sbjct: 3157 PEREVIVETISNPVTLTCDATGIPPPTIAWLKNYKRIENSDSLEVRILSGGSKLQIARSQ 3216
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y CIA N G+ + + IQ P + + +G+ + GIP
Sbjct: 3217 HSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3276
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W K+G + + + I S + I S + KYT A+N AG L
Sbjct: 3277 PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLN 3336
Query: 1662 VYDKPS 1667
VY P+
Sbjct: 3337 VYVTPT 3342
Score = 180 bits (439), Expect = 4e-44
Identities = 245/1198 (20%), Positives = 432/1198 (36%), Gaps = 101/1198 (8%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+T+ EC+ P ++W++ +K + N TL I+E D G +TCV
Sbjct: 2691 NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAA---NGHTLQIKEAQISDTGRYTCV 2747
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG ++ ++ P S ++L+ + +A+
Sbjct: 2748 ASNIAGEDELDFDVNIQVPPS-------------FQKLWEIGNMLDT-----GRNGEAKD 2789
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V + I L C A P P + W G + + + + VL+I K
Sbjct: 2790 VIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGG------RVLQIPRAKVED 2843
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS-----MIVRQGESVILSAQVV 759
G YT VAVN GE SL +++ P +IE S + V +S ++
Sbjct: 2844 AGRYTCVAVNEAGEDSLQYDVRVLV-----PPIIEGANSDLPEEVTVLVNKSALIECLSS 2898
Query: 760 GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
G+P P +W K+ +P+ I + ++ D G Y AEN+ G A+
Sbjct: 2899 GSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFN 2958
Query: 820 ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETI 879
+ V P P + + + +TV I L V+ P P ++W +N + I +
Sbjct: 2959 LNVHVP------PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNXQPIKLNTNT 3012
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
G ++++ V D G+Y C+A N AG+S +T+ V + H +S
Sbjct: 3013 LIVPGGRTLQIIRAKVS---DGGEYTCIAINXAGESKKKFSLTVYVPP-SIKDHDSESLS 3068
Query: 940 T---EEGKTVILECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDV 994
EG +V LEC+++ WY N + I+ H EI+ +G+
Sbjct: 3069 VVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQ 3128
Query: 995 GVIKCIV---KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWER 1051
V + I +D + + V E + E V + + W +
Sbjct: 3129 YVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLK 3188
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPE 1108
+ + I+ + + KL I + D G Y+CI + A+ +++PP
Sbjct: 3189 NYKRIE-NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPS 3247
Query: 1109 IITRLQNQKVNKGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
+ V+ E+ L++W KDG I ++ + L I
Sbjct: 3248 VAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNI 3307
Query: 1166 YDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
Y D G+Y+C N + + P+I E ++ +T +
Sbjct: 3308 YGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTYVDTSINIECRX 3367
Query: 1221 PDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
+ W K + + L++ + + I + D YTCV +
Sbjct: 3368 TGTPPPQINWLKNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNK 3425
Query: 1280 KVEVVEFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
+ F P +D E + +GS ++ P P+ W+ + + + H
Sbjct: 3426 HYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL-- 3483
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS 1396
++ + L + K E D+G Y N G + +L+ P G EI S
Sbjct: 3484 TVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVI 3542
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
+N N T I + ++ W+ +Q L R V
Sbjct: 3543 VN-------NPLELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQV 3592
Query: 1457 NEVD------ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ S A + + Y V ++P ++IT N + L C VP
Sbjct: 3593 EDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPP 3651
Query: 1511 PKVTWYRDGKKLKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
P +TW R+G++L+ Y C+A N G+ ++ +
Sbjct: 3652 PVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVN 3711
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKT 1627
P I + + + ++ + EG+P P + W K+G L N Y+I +
Sbjct: 3712 VPPNIKGGPQSLVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---EN 3766
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ I+ + + +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 3767 GFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 3824
Score = 176 bits (428), Expect = 8e-43
Identities = 257/1122 (22%), Positives = 431/1122 (38%), Gaps = 120/1122 (10%)
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
D+ +PP + + V + L C+ AIP P + WL G ++ +S++
Sbjct: 2097 DLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENR 2156
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKSM 744
SVLKI + + G YT A N G+ PP + + L +
Sbjct: 2157 ------SVLKIEDAQVQDTGRYTCEATNVAGKTEKK---NYNVNIWVPPNIGGSDELTQL 2207
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKA-----LPTKSDGDTHSITILKPKKVKD 799
V +G + L + G P P + W K PV + S G I+I + D
Sbjct: 2208 TVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEK---SD 2264
Query: 800 EGVYTLKAENSEGIAETSAVITVE-EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
+Y+ A N G A+ + V PT N+ + EI V +I L V
Sbjct: 2265 AALYSCVASNVAGTAKKEYNLQVYIRPTITNSG-----SHPTEIIVTRGKSISLECEVQG 2319
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P++TW ++ + ++ + +G ++L +V D+G Y CVA N AG +
Sbjct: 2320 IPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVS---DTGRYVCVAVNVAGMTDKK 2376
Query: 919 ARVTIDVEKVTFVKHLQ-KSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREI 975
+++ H ++ E +V L C+ S ST W+ + +S + I
Sbjct: 2377 YDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSTTWFKDGWPVSLSNSVRI 2436
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFI---RKLQDFEVKE 1030
+ GR D G C+V++ E + + +P I L+D +VKE
Sbjct: 2437 LSGGR--MLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKE 2494
Query: 1031 KDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
K L E+ + ++ W +DG+ ++ + + G R L I N V G Y+C
Sbjct: 2495 KQSVTLTCEVTGNPVPEITWHKDGQPLQ-EDEAHHIISGG--RFLQITNVQVPHTGRYTC 2551
Query: 1090 ILRD----ESCTAEVTVVELP----------PEIITRLQNQKVNKGNKATFEIELTKGDA 1135
+ +S + + V P PE +T + N + +A + A
Sbjct: 2552 LASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEA-----YSYPPA 2606
Query: 1136 LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE--- 1192
+ WFKDG+ ++ + +I++ G+ L+I + D+AG YSC N I E
Sbjct: 2607 TITWFKDGTPLESNRNIRILPGGR--TLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKV 2664
Query: 1193 --EPSIN----FTLRL-PEFILVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKF 1242
P IN + L P+ + + N L E IP +L +WYK ++ +
Sbjct: 2665 YIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASL--SWYKDGQPLKSDDHV 2722
Query: 1243 TLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPP---------KIVD 1292
+ ++ TL I++ D YTCV + +L +V ++ PP ++D
Sbjct: 2723 NIAAN--GHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLD 2780
Query: 1293 YEREYRIKR---GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKK 1349
R K + ++L + A P P W + + K I L I +
Sbjct: 2781 TGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL--TSSDKVLILPGGRVLQIPR 2838
Query: 1350 VENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILE------IDSSSINICWDE 1403
+ DAG Y N G ++ +V +L P G + L ++ S++ C
Sbjct: 2839 AKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIEGANSDLPEEVTVLVNKSALIECLSS 2898
Query: 1404 PENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISD 1463
++ E D +++S I + I N + R+ A N
Sbjct: 2899 GSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQ----ILNTQITDIGRYVCVAEN-----T 2949
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK--K 1521
A +Y+ + + + +N+T N I LTC G P P ++W ++ + K
Sbjct: 2950 AGSAKKYFNL--NVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNXQPIK 3007
Query: 1522 LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK 1581
L T Y CIA N GE + + + P I + +
Sbjct: 3008 LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINXAGESKKKFSLTVYVPPSIKDHDSESL 3067
Query: 1582 QKHKVGDEWLVTAVIE--GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSH 1639
V + V+ E +PPP + WYKNG + I + ++ IK+ + S
Sbjct: 3068 SVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ--MLHIKKAEVSD 3125
Query: 1640 SSKYTIEASNTAGTSSVEVTLKVYDKPS--KPEGPVIMREIS 1679
+ +Y A N AG L VY PS PE VI+ IS
Sbjct: 3126 TGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETIS 3167
Score = 171 bits (416), Expect = 2e-41
Identities = 230/1119 (20%), Positives = 428/1119 (38%), Gaps = 91/1119 (8%)
Query: 594 STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL 653
S L +E G E T ++ + PT + EG + L
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTL 1000
Query: 654 ECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAV 713
C+ P+P + W KG E++ + + +D +Y + + + + G Y A
Sbjct: 1001 PCKASGNPKPSVIWSKKG-ELISTSSAKFSAGADGSLY-----VVSPEGEESGEYVCTAT 1054
Query: 714 NREGEASLPIVLKIKT-----GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
N G A + L + G+ +P++ + V GE V L +V P P ITW
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDLRGLSQDKPVE-ISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
K + + + + + D G+Y A N G + + V P +
Sbjct: 1114 AKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR-NNEIISPSETITQNFDGEN 887
P + ++ V ++ I A+ T P+P ITW + + ++ E N DG
Sbjct: 1174 QRGP-----KHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHHVSNPDG-- 1224
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE-----E 942
L I + D+G Y CVA+N AG +T+ V++ V+ L+ Y T
Sbjct: 1225 -TLSIDQA-TPSDAGIYTCVATNIAGTDE--TEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 943 GKTVILECQTSHT--VSTKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ + C T + KW HN +E++G + I++EG D G C
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEEG--TLLVIASVTPYDNGEYIC 1338
Query: 1000 IVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVV-WERDG 1053
+ ++ T +K +P I+ ++ + V + L E+ + ++ W +D
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVSNVSVLLNQLTNLFCEVEGTPSPIIMWYKD- 1397
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ + + G I KL+ + D G YSC + + T++ V +PP II
Sbjct: 1398 NVQVTESSTIQTVNNGKILKLF--RATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 1111 TRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
++V+ +E KG + WFKDG + F + + + Q L + +
Sbjct: 1456 GTNFPKEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPL-FLGDPNVELLDRGQVLHLKN 1514
Query: 1168 CDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFIL-------VPANTDAYLTVEI 1220
+D G Y C V N+ + I T+ +P I + ++ + +E
Sbjct: 1515 ARRNDKGRYQCTVSNA-----AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLEC 1569
Query: 1221 PDETLD---VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
L +TWYK I + + I K + L I + D YTC + + T
Sbjct: 1570 KTRGLPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCHVANVAGTA 1627
Query: 1278 KLKVEVVEFPPKIVDYEREYRIKR----GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH 1333
+ V + P +++ + + +TL + P P W+ + +K +
Sbjct: 1628 EKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECNAAGNPSPILTWLKDGVPVKANDN 1687
Query: 1334 TKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEID 1393
+ I++ L I + D G Y + G +++ V +L P+ G
Sbjct: 1688 FR--IEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFI 1745
Query: 1394 SSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFR 1452
N+ + TG+ I ++ + Q ID + + + + I + +++ +R
Sbjct: 1746 VMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGLYR 1804
Query: 1453 AYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIELTCIFGGVPQP 1511
A N ++ K + T PT++ L + + L CI G+P P
Sbjct: 1805 CMAANTAG--------DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNP 1856
Query: 1512 KVTWYRDGKKLKTAKATYENRXX---XXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+TW +D + + TA+ + + Y C+A N GE + + +
Sbjct: 1857 SITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH 1916
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
+ P + + + + + V + + G P P + WYK+ L ++T +
Sbjct: 1917 EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNCLLSGST--SMTFLNRGQ 1974
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
+I I+ + S + Y A N+AG + + +L+V+ PS
Sbjct: 1975 IIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 170 bits (413), Expect = 5e-41
Identities = 251/1206 (20%), Positives = 454/1206 (37%), Gaps = 107/1206 (8%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S C+ YP ITWF+ ++ +++ ++ TL I ++AG ++CV
Sbjct: 2592 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PGGRTLQILNAQEDNAGRYSCV 2648
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG E+ V P + ++ P S PK
Sbjct: 2649 ATNEAGEMIKHYEVKVYIPPIINKGDLW--------------------GPGLS--PKEVK 2686
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
+ + + LEC AIP ++W G+ + D+++++A L+I +
Sbjct: 2687 IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH------TLQIKEAQISD 2740
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP--QVIEPLKSMIV--RQGES--------V 752
G YT VA N GE L + I+ PP Q + + +M+ R GE+ +
Sbjct: 2741 TGRYTCVASNIAGEDELDFDVNIQV----PPSFQKLWEIGNMLDTGRNGEAKDVIINNPI 2796
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L + P PT+TW K+ P+ + + + KV+D G YT A N G
Sbjct: 2797 SLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2856
Query: 813 IAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+ V P E A L +E+TV + + + +P P +W ++ +
Sbjct: 2857 EDSLQYDVRVLVPPIIEGANSDLP----EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQ 2912
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV 931
+ + +G ++++ T + D G Y CVA N+AG + + + V + +
Sbjct: 2913 PLLEDDHHKFLSNGRILQILNTQIT---DIGRYVCVAENTAGSAKKYFNLNVHVPP-SVI 2968
Query: 932 KHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
++ + L C+ S W N + I + I+ GR
Sbjct: 2969 GPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNXQPIKLNTNTLIVPGGRTLQIIRAKV 3028
Query: 990 XXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR-----KLQDFEVKEKDVAILEVEINS 1042
D G CI + E+ + +P I+ L V+E LE E N+
Sbjct: 3029 S--DGGEYTCIAINXAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNA 3086
Query: 1043 ETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
V+ W ++G +I + E + L+I+ V D G+Y C + + +
Sbjct: 3087 VPPPVITWYKNGRMITESTH---VEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKN 3143
Query: 1102 V---VELPPEIITRLQNQKVNK-GNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTI 1156
V +PP I + V N T + T + W K+ I+ S+ +++ I
Sbjct: 3144 FHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNYKRIENSDSLEVRI 3203
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPANT 1212
KL+I D+G Y+C N + A L+++ P +P + V
Sbjct: 3204 LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGE 3263
Query: 1213 DAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
+ L T + W K I E + TL I D +YTCV
Sbjct: 3264 NVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVAT 3323
Query: 1272 D--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--PQPNDEWIVNSKI 1327
+ + + V P + + ++ D ++ ++ + P P W+ N
Sbjct: 3324 NPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTYVDTSINIECRXTGTPPPQINWLKNGLP 3383
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP--- 1384
+ H + + + + I + + +D +Y N G + N+ + P+
Sbjct: 3384 LPLSSHIR--LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSM 3441
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLK 1444
G I + SS ++ S + ++ + Q + ++V + +
Sbjct: 3442 GTEEITVLKGSSTSMACITDGTPAPS--MAWLRDGQPLGLDAHLTVSTHGMV-LQLLKAE 3498
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYY--KVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
T S ++ A NE A E ++++ KV++ I + + I P +ELT
Sbjct: 3499 TEDSGKYTCIASNE-----AGEVSKHFILKVLEPPHINGSEEHEEISVIVNNP---LELT 3550
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
CI G+P PK+TW +DG+ L T Y C+A + G+ +
Sbjct: 3551 CIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDD 3610
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
+V + P I ++E + + + +PPP + W +NG +L+
Sbjct: 3611 KEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVR 3670
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
I + + ++I ++ YT ASN AG ++ E L V P+ GP + +
Sbjct: 3671 ILSGGR--YLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLN 3728
Query: 1681 ESVTIE 1686
+S +E
Sbjct: 3729 KSTVLE 3734
Score = 168 bits (409), Expect = 2e-40
Identities = 234/1077 (21%), Positives = 403/1077 (37%), Gaps = 80/1077 (7%)
Query: 632 IPPTFSKKPKAQY--VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + Y V + + L+C + P P I WL G+ I + + +
Sbjct: 1731 VPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRK- 1789
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEP-LKSMIVRQ 748
L I + G Y +A N G+ + + PP + L +V +
Sbjct: 1790 -----LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHV----PPTIKSSGLSERVVVK 1840
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALP--TKSDGDTHSITILKPKKVKDEGVYTLK 806
+ V L G P P+ITW K+++PV K + I K ++D G YT
Sbjct: 1841 YKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTL-LEDAGRYTCV 1899
Query: 807 AENSEGIAETSAVITVEEPTE-ENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A N+ G + + V EP E+A + TV ++L + NPVP IT
Sbjct: 1900 ATNAAGETQQHIQLHVHEPPSLEDA------GKMLNETVLVSNPVQLECKAAGNPVPVIT 1953
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
WY++N ++S S ++T G+ I++ + D+G YKCVA NSAG + ++ V
Sbjct: 1954 WYKDNCLLSGSTSMTFLNRGQIIDIESAQIS---DAGIYKCVAINSAGATE--LFYSLQV 2008
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDH-REIIQEGRXX 982
+ V LEC+ S W + +S + +++ GR
Sbjct: 2009 HVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR-- 2066
Query: 983 XXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVAILEVE 1039
D G C+ + + + P + + Q+ V L +
Sbjct: 2067 ILALTSTQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQ 2126
Query: 1040 INS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA 1098
++ + W +DG + K E R ++ I + V D G Y+C + +
Sbjct: 2127 SDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLK---IEDAQVQDTGRYTCEATNVAGKT 2183
Query: 1099 EV----TVVELPPEI--ITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNH 1151
E + +PP I L V +GN + E + + W K GS + +
Sbjct: 2184 EKKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSM 2243
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA-----ILTVEEPSINFTLRLPEFI 1206
++ I ++L+I + DA YSC N TA + P+I + P I
Sbjct: 2244 GRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI 2303
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
+V L E IP T VTW K + + ++ + L ++ D
Sbjct: 2304 IVTRGKSISLECEVQGIPPPT--VTWMKDGHPLIKAKGVEILDE--GHILQLKNIHVSDT 2359
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER---EYRIKRGSDVTLLVDYQAFPQPND 1319
Y CV ++ T K ++ V PP I+ R + + V+L + P P+
Sbjct: 2360 GRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPST 2419
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
W + + + I S L + + DAG Y + N G +++L
Sbjct: 2420 TWFKDGWPVSLSNSVR--ILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLV 2477
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQT 1438
P G+ + ++ E TGN I + + Q + E + + +
Sbjct: 2478 PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRF-L 2536
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
I N++ + R+ A + S + + + T + P +++T N
Sbjct: 2537 QITNVQVPHTGRYTCLASSPAGHKSRSFSLNVF--VSPTIAGVGSDGNP-EDVTVILNSP 2593
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYKCIAFNDH 1556
L C P +TW++DG L++ + Y C+A N+
Sbjct: 2594 TSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEA 2653
Query: 1557 GEVETSCVVGIQQKPVITISN------EDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
GE+ V + P+I + + K KV + + IP + WYK+G
Sbjct: 2654 GEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDG 2713
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
L++D NI T ++IKE + S + +YT ASN AG ++ + + PS
Sbjct: 2714 QPLKSDDHVNIAANGHT--LQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPS 2768
Score = 167 bits (407), Expect = 3e-40
Identities = 235/1077 (21%), Positives = 417/1077 (38%), Gaps = 79/1077 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 847
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 848 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 906
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 962
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 963 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 1015 SKKGELISTSSAKFSAGADG---SLYVVSPEGE-ESGEYVCTATNTAGYAKRKVQLTVYV 1070
Query: 926 EKVTF--VKHLQKSYETE----EGKTVILECQTSHTVS--TKWYHNKKEISGMDHREIIQ 977
F ++ L + E G+ V L C+ W + IS R
Sbjct: 1071 RPRVFGDLRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL 1130
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEKDVA 1034
D G+ C+ + + VK + P+ R + +V+
Sbjct: 1131 P--SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ V+ W + G + + G L I + D G Y+C+ +
Sbjct: 1189 DIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQATPSDAGIYTCVATN 1245
Query: 1094 ESCTAEV----------TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ T E TV +L P T Q + N+ + + T ++W +G
Sbjct: 1246 IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTP-KPTIKWLHNG 1304
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFT 1199
E+ ++I + L I D GEY C E G ++ L V P +
Sbjct: 1305 RELT-GREPGISILEEGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKD 1363
Query: 1200 LRLPEFILVPAN--TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRK 1257
+ V N T+ + VE + + WYK ++ TE T+ + + L + +
Sbjct: 1364 KEQVSNVSVLLNQLTNLFCEVEGTPSPI-IMWYKDN--VQVTESSTIQTVNNGKILKLFR 1420
Query: 1258 CTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQAF 1314
T +D Y+C ++ T++ + V PP I+ ++ +E + DV L +
Sbjct: 1421 ATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPKEVSVVLNRDVALECQVKGT 1480
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMN 1374
P P+ W + K + +D + L +K D G Y+ + N G ++
Sbjct: 1481 PFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIK 1539
Query: 1375 VTILDKPSPPGKPNILEIDSSSINICWDEPENTG-NSTIIYYVVEYQEIDTTEWISVKNI 1433
+TI PS G +I ++ E + G I + + Q I ++ I
Sbjct: 1540 LTIYIPPSIKGGNVTTDISVLINSLIKLECKTRGLPMPAITWYKDGQPIMSSS--QALYI 1597
Query: 1434 TKTQ-TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNIT 1492
K Q I + + S + + N ++ +E + + V I+ + PL N
Sbjct: 1598 DKGQYLHIPRAQVSDSATYTCHVAN---VAGTAEKSFHVDVYVPPMIEG-NLATPL-NKQ 1652
Query: 1493 TEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYENRXXXXXXXXXXXXXXXYKC 1550
+ L C G P P +TW +DG +K Y C
Sbjct: 1653 VVIAHSLTLECNAAGNPSPILTWLKDGVPVKANDNFRIEAGGKKLEIMSAQEIDRGQYIC 1712
Query: 1551 IAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
+A + GE E V + P I +E V + + + G PPP ++W K+G
Sbjct: 1713 VATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDG 1772
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
++ + I + V I + + S++ Y A+NTAG E + V+ P+
Sbjct: 1773 QLIDERDGFKILLNGRKLV--IAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT 1827
Score = 163 bits (396), Expect = 6e-39
Identities = 241/1072 (22%), Positives = 408/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 3244 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 3302
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M
Sbjct: 3303 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTYVD- 3358
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 3359 TSINIECRXTGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3418
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 3419 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 3473
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 3474 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 3525
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 3526 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 3585
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 3586 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 3643
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 3644 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 3700
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 3701 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 3758
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 3759 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 3814
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 3815 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 3872
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 3873 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 3932
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 3933 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 3990
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 3991 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 4041
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 4042 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 4099
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 4100 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4159
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 4160 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 4215
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 4216 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 4267
Score = 159 bits (385), Expect = 1e-37
Identities = 222/1029 (21%), Positives = 395/1029 (38%), Gaps = 84/1029 (8%)
Query: 680 ISVAIESDMHMYCSV-LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+++ ++ + SV L I V EG Y +AV+ G + EPP VI
Sbjct: 468 VTLGVDQYLKESASVSLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVS----EPPPVI 523
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKV 797
+ ++ V GE +L+ ++ +TW +N++ V+ A P + + LK K
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF 583
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y + G + S +TV+EP + P + Q T + + ++ T
Sbjct: 584 NDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP-----KNQSFTGGSE--VSIMCSAT 636
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P I W N+ I S DG L I N + D+G Y C+ASNSAG
Sbjct: 637 GYPKPKIAWTVNDMFIVGSHRYRMTSDG---TLFIKNAAPK-DAGIYGCLASNSAGTDKQ 692
Query: 918 GARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHRE 974
+ + I+ K+ V Q G ++EC+TS KW+ E+
Sbjct: 693 NSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTF-- 747
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+I + D G C+ ++ T + + + P FI++ D ++
Sbjct: 748 LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIG 807
Query: 1032 DVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
L + + W R D I + + L+I N D+G Y C
Sbjct: 808 SNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYIC 867
Query: 1090 ILRDE--SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGDALV--RWFKD 1142
++ +E TV + P I V +G + T L G+ + RW K+
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-----NSKCTAILTVEEPSIN 1197
+ + + +I + DG L I L D GEY+C N+K T+++ P+I
Sbjct: 928 SAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 1198 FTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLII 1255
++ I +P + + V W KK +I + KF+ +D +L +
Sbjct: 985 HGQQILSTIEGIPVTLPCKAS---GNPKPSVIWSKKGELISTSSAKFSAGAD---GSLYV 1038
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIV--------DYEREYRIKRGSDVT 1306
++ EY C + K KV++ V P++ D E + G +VT
Sbjct: 1039 VSPEGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDLRGLSQDKPVEISVLAGEEVT 1098
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
L + ++ P P W +++I + S S+ I + +D+G+Y N
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKITETRTSDSGMYLCVATNIA 1156
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G+ + + + P P L++ + D P N + + V+ + + +T
Sbjct: 1157 GNVTQAVKLNVHVPPKIQRGPKHLKV---QVGQRVDIPCNAQGTPL--PVITWSKGGSTM 1211
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE- 1485
+ ++ ++ + Y +I+ E TE ++E PTVE
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE-TEITLHVQE----PPTVED 1266
Query: 1486 -KPLKNITTE---PNEDIELTCIFGGVPQPKVTWYRDGKKL---KTAKATYENRXXXXXX 1538
+P N T + N+ IE C G P+P + W +G++L + + E
Sbjct: 1267 LEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEEGTLLVIA 1326
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEG 1598
Y C+A N+ G E + + PVI + + + +EG
Sbjct: 1327 SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVSNVSVLLNQLTNLFCEVEG 1386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P ++WYK + ++ + I T ++++ + +Y+ +A N AGTS
Sbjct: 1387 TPSPIIMWYK--DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 1659 TLKVYDKPS 1667
+ V P+
Sbjct: 1445 NIDVLVPPT 1453
Score = 152 bits (368), Expect = 2e-35
Identities = 228/1072 (21%), Positives = 381/1072 (35%), Gaps = 81/1072 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + PK Q GS++ + C P+P IAW IV + SD
Sbjct: 611 PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT--SD----- 663
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N G Y +A N G L+ E P+++ ++V G+
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYI----EAPKLMVVQSELLVALGDIT 719
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G P P + W K + ++ + ++ + D G YT A N G
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NN 870
A + V PP+FI +++++ + L V P P+I W R N
Sbjct: 780 RATGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I S +++ L I N+ + D G Y C A N GK VT+
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPL 891
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
+ EG+ + L C + +W N + + + +G
Sbjct: 892 IGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQ 951
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA-D 1046
+ + V T VV +P Q E L + +
Sbjct: 952 LQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPS 1011
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
V+W + GE+I K+ G LY+ + + GEY C + + A+ V V
Sbjct: 1012 VIWSKKGELISTSSAKFSAGADG---SLYVVSPEGEESGEYVCTATNTAGYAKRKVQLTV 1068
Query: 1104 ELPPEIITRLQNQKVNK--------GNKATFEIELTK-GDALVRWFKDGSEIQ-FSNHIQ 1153
+ P + L+ +K G + T E+ ++ W K+ I FS
Sbjct: 1069 YVRPRVFGDLRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHT 1128
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPEFILVP 1209
G +KI + D+G Y C GN L V P R P+ + V
Sbjct: 1129 FLPSGS---MKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPK--IQRGPKHLKVQ 1183
Query: 1210 ANTDAYLTVEIPDETLDV-TWYKKKS-VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L V TW K S ++ D E D TL I + T D YT
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATPSDAGIYT 1240
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVT-LLVDY----QAFPQPNDEW 1321
CV + T + ++ + V+ PP + D E Y V +++ + P+P +W
Sbjct: 1241 CVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKW 1300
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ N + + + SI + L I V D G Y N G + + N+ + P
Sbjct: 1301 LHNGRELTG-REPGISILEEGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Query: 1382 SPPGKPNILEIDS--SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
K + + + + + E E T + I++Y + TE +++ + +
Sbjct: 1360 VIKDKEQVSNVSVLLNQLTNLFCEVEGTPSPIIMWYK---DNVQVTESSTIQTVNNGK-- 1414
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNE 1497
I L + Y+ ++I+ S+ +Y+ + + PT+ K ++ N
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGTSQ--KYFNI---DVLVPPTIIGTNFPKEVSVVLNR 1469
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXXXXXXYKCIAFN 1554
D+ L C G P P + W++DGK L E Y+C N
Sbjct: 1470 DVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSN 1529
Query: 1555 DHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE 1614
G+ + I P I N + + G+P P + WYK+G +
Sbjct: 1530 AAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECKTRGLPMPAITWYKDGQPIM 1589
Query: 1615 NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+ + +K + I + S S+ YT +N AGT+ + VY P
Sbjct: 1590 SSSQ--ALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP 1639
Score = 151 bits (365), Expect = 4e-35
Identities = 240/1118 (21%), Positives = 424/1118 (37%), Gaps = 93/1118 (8%)
Query: 599 IVEAPLSDHGS-EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRL 657
I + LSD G E D+ E PP + P V G +L C +
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 658 VAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
++ + ++ W ++ E + +++ L++ +VK G Y + + G
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLS-----LELKSVKFNDAGEYHCMVSSEGG 598
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA 777
++ + L + +EPP+V K+ G V + G P+P I W N+ +
Sbjct: 599 SSAASVFLTV----QEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 778 LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-AETSAVITVEEPTEENAEPPLFI 836
+ + +K KD G+Y A NS G + S + +E P + L +
Sbjct: 655 -SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLV 713
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
+ITV E + + P P + W++ + + PS + + + L+
Sbjct: 714 -ALGDITVME-------CKTSGIPPPQVKWFKGDLELRPSTFLIID---PLLGLLKIQET 762
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSH 954
++D+GDY CVA N AG+++ ++T+DV E G V L C Q
Sbjct: 763 QDLDAGDYTCVAINEAGRAT--GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP 820
Query: 955 TVSTKW--YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETST 1008
+ KW N S I + R D G C ++Q ++ T
Sbjct: 821 EPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 1009 MLVVKETIPEFIRKLQDF-EVKEKDVAILEVEI--NSETADVVWERDGEIIKPKKNKYDF 1065
+ V + I V E L + + + W ++ ++ +N Y
Sbjct: 881 TVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML--LQNPYIT 938
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITRLQNQKVNKGN 1122
+ L+I + D GEY+C+ + + T T VV + P I Q +G
Sbjct: 939 VRSD--GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
T + + V W K G I S+ DG L + + +++GEY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG---SLYVVSPEGEESGEYVCTA 1053
Query: 1179 --EVGNSKCTAILTV-EEPSINFTLR-----LPEFILVPANTDAYLTVEIPD-ETLDVTW 1229
G +K LTV P + LR P I V A + L E+ +TW
Sbjct: 1054 TNTAGYAKRKVQLTVYVRPRVFGDLRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 1113
Query: 1230 YKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
K+ +I + + T + ++ I + D Y CV + V++ V P
Sbjct: 1114 AKETQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP 1170
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLT 1346
PKI + +++ G V + + Q P P W S ++ +H + + +L+
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEH---HVSNPDGTLS 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS-----PPGKPNILEIDSSSINICW 1401
I + +DAGIY N G + E+ + + + P+ PP E ++ I +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ-RIEF 1286
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTE-WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
P I ++ +E+ E IS+ T I ++ + + AVNE
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILE-EGTLLVIASVTPYDNGEYICVAVNE-- 1343
Query: 1461 ISDASETTEYYKVIKETKIQSPTV---EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR 1517
A T Y + K+ P V ++ + N++ N+ L C G P P + WY+
Sbjct: 1344 ---AGTTERKYNL----KVHVPPVIKDKEQVSNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Query: 1518 DGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
D ++ + T N Y C A N G + + + P I
Sbjct: 1397 DNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIG 1456
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
+N + + + + ++G P P++ W+K+G L + N+ ++ V+ +K
Sbjct: 1457 TNFPKEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
+R+ +Y SN AG + ++ L +Y PS G V
Sbjct: 1516 RRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553
Score = 149 bits (362), Expect = 8e-35
Identities = 240/1167 (20%), Positives = 420/1167 (35%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 3451 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 3507
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 3508 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 3562
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 3563 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 3593
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 3594 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 3648
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 3649 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3708
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 3709 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 3761
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 3762 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 3818
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 3819 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3878
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 3879 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 3938
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 3939 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3995
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 3996 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 4051
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 4052 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 4107
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S +L I D YTC+ + S+T K
Sbjct: 4108 PPDITWHKDGRAIVESIRQRVLSSG----SLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4163
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 4164 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 4219
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 4220 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 4268
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 4269 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4325
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K ++ P V K + EP + L C G P P + W
Sbjct: 4326 TYVCTAENSVGFVKATGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN 4385
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 4386 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4445
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 4446 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 4500
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 4501 QKEDTSEFECVARNLMGSVLVRVPVIV 4527
Score = 122 bits (293), Expect = 2e-26
Identities = 207/965 (21%), Positives = 347/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 3619 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 3675
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 3676 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 3728
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 3729 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 3788
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 3789 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 3841
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 3842 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 3899
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 3900 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3958
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 3959 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 4018
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 4019 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 4075
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 4076 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 4132
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 4133 S---LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 4186
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 4187 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 4243
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 4244 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 4303
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P G
Sbjct: 4304 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKATGFVYVKEPPVFKG----- 4354
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ S+ W EP G + I+ V+ T +W + I+ L S
Sbjct: 4355 DYPSN-----WIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAI 4407
Query: 1451 FRAYAVNEVDISDAS-ETTEYYKVIKETK---IQSPTVE--KPLKNITTEPNEDIELTCI 1504
+ VNE D D + T V++ + +QSP + +P++ + + I L C
Sbjct: 4408 YGT--VNE-DAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKII-LNCQ 4463
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 4464 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 4523
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 4524 PVIVQ 4528
Score = 84.6 bits (200), Expect = 3e-15
Identities = 111/540 (20%), Positives = 204/540 (37%), Gaps = 34/540 (6%)
Query: 1163 LKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
L I L D G Y C G + V EP +++P + V A LT
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPP--VIQVPNNVTVTPGERAVLTC 541
Query: 1219 EIPDET-LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
I ++TW + + E I + +L ++ +D EY C++ ++
Sbjct: 542 LIISAVDYNLTWQRNDRDVRLAEP-ARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSS 600
Query: 1278 KLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
V + V+ PPK+ + GS+V+++ +P+P W VN I +
Sbjct: 601 AASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRM 660
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS 1396
+ D +L IK DAGIY N+ G + ++ P + L +
Sbjct: 661 TSDG---TLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGD 717
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
I + + + ++ + E+ + ++ + + IQ + + + A+
Sbjct: 718 ITVMECKTSGIPPPQVKWFKGDL-ELRPSTFLIIDPLLGL-LKIQETQDLDAGDYTCVAI 775
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY 1516
NE A T K+ + +++P +++ E ++ L C G P+P + W
Sbjct: 776 NE-----AGRATG--KITLDVGSPPVFIQEPA-DVSMEIGSNVTLPCYVQGYPEPTIKWR 827
Query: 1517 R------DGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ- 1569
R + + + Y C A N G++++ V +
Sbjct: 828 RLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGL 887
Query: 1570 -KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P+I IS + + L ++ G P PE W KN L + IT + S
Sbjct: 888 VAPLIGIS-PSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPY--ITVRSDGS 944
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWK 1688
+ I+ ++ +YT ASN AGT++ ++ V+ P+ G I+ I VT+ K
Sbjct: 945 -LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCK 1003
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 5/81 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C GYP+P+I W I S ++M D TL I+ P+DAG + C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD----GTLFIKNAAPKDAGIYGC 681
Query: 584 VAKNAAGFASSTTEL-IVEAP 603
+A N+AG + L +EAP
Sbjct: 682 LASNSAGTDKQNSTLRYIEAP 702
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 772
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 773 VAINEAGRATGKITLDVGSP 792
Score = 51.2 bits (117), Expect = 4e-05
Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V EC+ P P ITW++ +I S ++ D L I++
Sbjct: 3065 ESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 3121
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 3122 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 3180
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 3181 PPTIAWLKNYKRIENSD-SLEVRILS 3205
Score = 51.2 bits (117), Expect = 4e-05
Identities = 31/95 (32%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 4261 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 4314
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF +T + V+ P
Sbjct: 4315 VIERVSKEDSGTYVCTAENSVGFVKATGFVYVKEP 4349
Score = 49.2 bits (112), Expect = 2e-04
Identities = 44/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 1605 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 1658
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC G P P +TW + +K + +F++ + + +E+ D G + CVA
Sbjct: 1659 LTLECNAAGNPSPILTWLKDGVPVKANDNFRIEAGGKKLEIMSAQEI---DRGQYICVAT 1715
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q +
Sbjct: 1716 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI 1775
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVS 1798
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%)
Query: 489 NEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
++K ++ V PT + ++ V K +P V +C G P P ITW +
Sbjct: 1814 HKKEFEVTVHVPPTIKSSGLSERVVVKYKP--------VALQCIANGIPNPSITWLKDDQ 1865
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ +Q V L I + EDAG +TCVA NAAG +L V P S
Sbjct: 1866 PVNTAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Score = 47.2 bits (107), Expect = 6e-04
Identities = 27/82 (32%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G C+V+G P P I W R+ I+ S + + +L I EDAG +
Sbjct: 4363 PLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVNEDAGDY 4418
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA N AG + L +++P
Sbjct: 4419 TCVATNEAGVVERSMSLTLQSP 4440
Score = 46.8 bits (106), Expect = 9e-04
Identities = 38/185 (20%), Positives = 70/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 4261 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4320
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ + V +++ PV + +G ++ ++G P
Sbjct: 4321 KEDSGTYVCTAENSVGFVKATGFVYVKEPPVFK-GDYPSNWIEPLGGNAILNCEVKGDPT 4379
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 4380 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4436
Query: 1662 VYDKP 1666
+ P
Sbjct: 4437 LQSPP 4441
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 4183 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 4239
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 4240 CVANNAAGEDTHTVSLTV 4257
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 3989 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 4045
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 4046 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4091
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 4455 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 4510
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 4511 VARNLMGSVLVRVPVIVQ 4528
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 3911 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 3963
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 3964 GRYTCVARNAAGSAHRHVTLHVHEP 3988
>X73113-1|CAA51544.1| 1142|Homo sapiens fast MyBP-C protein.
Length = 1142
Score = 231 bits (564), Expect = 3e-59
Identities = 187/768 (24%), Positives = 335/768 (43%), Gaps = 41/768 (5%)
Query: 1019 FIRKLQD-FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
F +KL ++V + L VEI+ + W ++G+ IKP +KY FE G R L I
Sbjct: 258 FTKKLDPAYQVDRGNKIKLMVEISDPDLTLKWFKNGQEIKPS-SKYVFENVGKKRILTIN 316
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALV 1137
++ D+ Y ++DE C E+ V E P I+T L++Q+V G++ +E+++ A V
Sbjct: 317 KCTLADDAAYEVAVKDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMAVEVSEEGAQV 376
Query: 1138 RWFKDGSEI----QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
W KDG E+ F + DGK+ L D +D G Y +C A L VEE
Sbjct: 377 MWMKDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIVEE 436
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
+ + + + V A+ A E+ DE + WYK + +++ T+ + L
Sbjct: 437 KQLEVLQDIAD-LTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKL 495
Query: 1254 IIRKCTEDDQCEYTCV-------LLDAK-STTKLKVEVV--EFPPKI-VD-----YEREY 1297
+I +D+ +YT V L AK + ++KVE V + PPKI +D E
Sbjct: 496 VIDDVRPEDEGDYTFVPDGYALGSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSENAI 555
Query: 1298 RIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK-HTKPSIDSKSASLTIKKVENTDAG 1356
+ G+ + L V P P W+ ++ + T+ +S I+ + D G
Sbjct: 556 VVVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFVIESAQREDEG 615
Query: 1357 IYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
Y +++ N G + + ++D P PP I + + W+ P G + Y+
Sbjct: 616 RYTIKVTNPVGEDVASIFLQVVDVPDPPEAVRITSVGEDWAILVWEPPMYDGGKPVTGYL 675
Query: 1417 VEYQEIDTTEWISVKNITKTQTSIQNLKTNSS--YRFRAYAVNEVDISDASETTEYYKVI 1474
VE ++ + W+ + T+T+ ++ K Y R +AVN + +S S T+ + I
Sbjct: 676 VERKKKGSQRWMKLNFEVFTETTYESTKMIEGILYEMRVFAVNAIGVSQPSMNTKPFMPI 735
Query: 1475 KETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG-KKLKTAKATYENRX 1533
T + + + + TT GG+ V + +G ++ A R
Sbjct: 736 APTSEPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVERC 795
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV------GIQQKPVITISNEDIKQKH--K 1585
++ + N G E + + I + P I + ++Q + K
Sbjct: 796 GFTVKNLPTGARILFRVVGVNIAGRTEPATLAQPVTIREIAEPPKIRLPRH-LRQTYIRK 854
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
VG++ + +G P P+V+W K G L+ + ++ T + +V +++ RS S +Y +
Sbjct: 855 VGEQLNLVVPFQGKPRPQVVWTKGGAPLDTSR-VHVRTSDFDTVFFVRQAARSDSGEYEL 913
Query: 1646 EASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEK 1705
+ + ++V +K P V+++E+ + +EW+ P DDG E+ Y ++K
Sbjct: 914 SVQIENMKDTATIRIRVVEKAGPPIN-VMVKEVWGTNALVEWQAPKDDGNSEIMGYFVQK 972
Query: 1706 HEPDNNRWIKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFSEA 1752
+ W V +R+ T C + L EY FRV +N G S++
Sbjct: 973 ADKKTMEWFNV--YERNRHTSCTVSDLIVGNEYYFRVYTENICGLSDS 1018
Score = 142 bits (345), Expect = 9e-33
Identities = 152/647 (23%), Positives = 269/647 (41%), Gaps = 47/647 (7%)
Query: 920 RVTIDVEK-VTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQ 977
+ ++V+K F K L +Y+ + G + L + S ++ KW+ N +EI
Sbjct: 247 KAKVEVKKSAAFTKKLDPAYQVDRGNKIKLMVEISDPDLTLKWFKNGQEIKPSSKYVFEN 306
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILE 1037
G+ D + VKD++ T L VKE + L+D +V D +
Sbjct: 307 VGKKRILTINKCTLADDAAYEVAVKDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMA 366
Query: 1038 VEINSETADVVWERDG-EIIKPK--KNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
VE++ E A V+W +DG E+ + K +Y F+K G L + D G Y I
Sbjct: 367 VEVSEEGAQVMWMKDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGG 426
Query: 1095 SCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQL 1154
C AE+ V E E++ + + V +A F+ E++ +W+K+G E++ S I +
Sbjct: 427 QCEAELIVEEKQLEVLQDIADLTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITI 486
Query: 1155 TIDGKKQKLKIYDCDLDDAGEY------------SCEVG--NSKCTAILTVEEPSINFTL 1200
+ G+ KL I D +D G+Y S ++ K + E P I+
Sbjct: 487 SHVGRFHKLVIDDVRPEDEGDYTFVPDGYALGSLSAKLNFLEIKVEYVPKQEPPKIHLDC 546
Query: 1201 ---RLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKSVIEDTEKFTLISD-VKKRTLII 1255
I+V A L V I E V TW K V TE T I V + +I
Sbjct: 547 SGKTSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFVI 606
Query: 1256 RKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKR-GSDVTLLVDYQ 1312
+D+ YT + + + + ++VV+ P D RI G D +LV ++
Sbjct: 607 ESAQREDEGRYTIKVTNPVGEDVASIFLQVVDVP----DPPEAVRITSVGEDWAILV-WE 661
Query: 1313 AFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT---DAGIYKLRL--ENNCG 1367
+ + + +K K ++ + T E+T + +Y++R+ N G
Sbjct: 662 PPMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFTETTYESTKMIEGILYEMRVFAVNAIG 721
Query: 1368 HADVEMNVTILDKPSPPGKPNIL---EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
+ MN +P +P L ++ ++ + W P G I Y+VEY +
Sbjct: 722 VSQPSMNTKPFMPIAPTSEPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEYCLEGS 781
Query: 1425 TEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVN---EVDISDASETTEYYKVIKETKI 1479
EW+ + + + + +++NL T + FR VN + + ++ ++ + KI
Sbjct: 782 EEWVPANTEPVERCGFTVKNLPTGARILFRVVGVNIAGRTEPATLAQPVTIREIAEPPKI 841
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK 1526
+ P + + + E + L F G P+P+V W + G L T++
Sbjct: 842 RLPRHLR--QTYIRKVGEQLNLVVPFQGKPRPQVVWTKGGAPLDTSR 886
Score = 116 bits (278), Expect = 1e-24
Identities = 107/479 (22%), Positives = 192/479 (40%), Gaps = 35/479 (7%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKELKRSHSSKYTI 1645
G++ + I G PPP W K + I + S I+ +R +YTI
Sbjct: 560 GNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFVIESAQREDEGRYTI 619
Query: 1646 EASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEK 1705
+ +N G + L+V D P PE V + + + + W+PP+ DGG +T Y +E+
Sbjct: 620 KVTNPVGEDVASIFLQVVDVPDPPEA-VRITSVGEDWAILVWEPPMYDGGKPVTGYLVER 678
Query: 1706 HEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTAL 1764
+ + RW+K+ TY K+ E Y RV A N +G S+ ++ ++P +
Sbjct: 679 KKKGSQRWMKLNFEVFTETTYESTKMIEGILYEMRVFAVNAIGVSQPSMNTKPFM----P 734
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXX 1823
P+ + + + + W P + G I Y VE EG ++W
Sbjct: 735 IAPTSEPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVER 794
Query: 1824 A--RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS 1881
++ L FR+ N G + P T +TI + PP + ++ R
Sbjct: 795 CGFTVKNLPTGARILFRVVGVNIAGRTEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRK 854
Query: 1882 VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV-TVGGSVHEHCIENIKEKD-EIIFR 1939
V G + N ++ F +GK ++V T GG+ + +++ D + +F
Sbjct: 855 V-----------GEQL-NLVVPF---QGKPRPQVVWTKGGAPLDTSRVHVRTSDFDTVFF 899
Query: 1940 I-------SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW 1992
+ S E + V + + + + P + ++ V + W P+
Sbjct: 900 VRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPPINVMVKEVWGTNALVEWQAPKD 959
Query: 1993 DGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSE 2051
DG + ++GY + D W V + + +T + DL + Y R+Y N GLS+
Sbjct: 960 DGNSEIMGYFVQKADKKTMEWFNVYERNRHT-SCTVSDLIVGNEYYFRVYTENICGLSD 1017
Score = 86.6 bits (205), Expect = 9e-16
Identities = 103/432 (23%), Positives = 166/432 (38%), Gaps = 43/432 (9%)
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA-GTSSVEVT---LK 1661
WYKNG ++ K I+ + + I +++ YT A G+ S ++ +K
Sbjct: 471 WYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDGYALGSLSAKLNFLEIK 530
Query: 1662 VYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
V P K E P I + S + T E + G +I P W+K +V
Sbjct: 531 VEYVP-KQEPPKIHLDCSGK--TSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFT 587
Query: 1722 ------------DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
D ++ I+ E + + NPVG E + +DVP
Sbjct: 588 TTEGRTRIEKRVDCSSFVIESAQREDEGRYTIKVTNPVG-----EDVASIFLQVVDVPD- 641
Query: 1770 XXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARIQ- 1827
+ + + W P +GG P+ Y VE K++G ++W +
Sbjct: 642 PPEAVRITSVGEDWAILVWEPPMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFTETTYES 701
Query: 1828 -KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKW 1886
K+ Y+ R++A N IG S P + + P S+P + +V + T + TLKW
Sbjct: 702 TKMIEGILYEMRVFAVNAIGVSQPSMNTKPF---MPIAPTSEPLHLIVEDVTDTTTTLKW 758
Query: 1887 TEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTV 1946
P G I Y++E+ + W T ++N+ I+FR+ N
Sbjct: 759 RPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVERCGFTVKNLPTGARILFRVVGVNIA 818
Query: 1947 GVSLP-TESQSVRLEKHATVPS----PPTAPLEIRMVGS--NIVMTSWGTPE----W-DG 1994
G + P T +Q V + + A P IR VG N+V+ G P W G
Sbjct: 819 GRTEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKPRPQVVWTKG 878
Query: 1995 GAPLLGYNIAIR 2006
GAPL + +R
Sbjct: 879 GAPLDTSRVHVR 890
Score = 80.6 bits (190), Expect = 6e-14
Identities = 69/309 (22%), Positives = 124/309 (40%), Gaps = 25/309 (8%)
Query: 1282 EVVEFPPKIV---DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK-HTKPS 1337
E+ E PPKI + Y K G + L+V +Q P+P W + + H + S
Sbjct: 834 EIAE-PPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKPRPQVVWTKGGAPLDTSRVHVRTS 892
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
+++ +D+G Y+L ++ + + +++K PP + E+ ++
Sbjct: 893 --DFDTVFFVRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPPINVMVKEVWGTNA 950
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK-TQTSIQNLKTNSSYRFRAYAV 1456
+ W P++ GNS I+ Y V+ + T EW +V + T ++ +L + Y FR Y
Sbjct: 951 LVEWQAPKDDGNSEIMGYFVQKADKKTMEWFNVYERNRHTSCTVSDLIVGNEYYFRVYTE 1010
Query: 1457 NEVDISDASETTEYYKVIKETKI-------------QSPTVEKPLKNITTEPNEDIELTC 1503
N +SD+ ++ I +T I +P PL + L C
Sbjct: 1011 NICGLSDSPGVSKNTARILKTGITFKPFEYKEHDFRMAPKFLTPLIDRVVVAGYSAALNC 1070
Query: 1504 IFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
G P+PKV W ++ ++ K Y+ Y C A N+ GE
Sbjct: 1071 AVRGHPKPKVVWMKNKMEIREDPKFLITNYQGVLTLNIRRPSPFDAGTYTCRAVNELGEA 1130
Query: 1560 ETSCVVGIQ 1568
C + ++
Sbjct: 1131 LAECKLEVR 1139
Score = 62.5 bits (145), Expect = 2e-08
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 6/136 (4%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTS 1986
IE+ + +DE + I N VG + S+ L+ VP PP A + I VG + +
Sbjct: 606 IESAQREDEGRYTIKVTNPVGEDVA----SIFLQV-VDVPDPPEA-VRITSVGEDWAILV 659
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P +DGG P+ GY + + WM++ + + E Y +R++A N
Sbjct: 660 WEPPMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFTETTYESTKMIEGILYEMRVFAVNA 719
Query: 2047 IGLSEPLESDEPFKVI 2062
IG+S+P + +PF I
Sbjct: 720 IGVSQPSMNTKPFMPI 735
Score = 58.8 bits (136), Expect = 2e-07
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 1/96 (1%)
Query: 508 MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
MAP F+ L + G + C V G+P+P++ W + I+ F + + V T
Sbjct: 1047 MAPKFLTPLIDRVVVAGYSAALNCAVRGHPKPKVVWMKNKMEIREDPKF-LITNYQGVLT 1105
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
L IR P DAGT+TC A N G A + +L V P
Sbjct: 1106 LNIRRPSPFDAGTYTCRAVNELGEALAECKLEVRVP 1141
Score = 53.2 bits (122), Expect = 1e-05
Identities = 43/198 (21%), Positives = 74/198 (37%), Gaps = 7/198 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P ++ L W P +GG P+T Y++E K + W K+ + E
Sbjct: 640 PDPPEAVRITSVGEDWAILVWEPPMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFT--ET 697
Query: 1926 CIENIKEKDEIIF--RISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
E+ K + I++ R+ A N +GVS P+ + + P+ L + V
Sbjct: 698 TYESTKMIEGILYEMRVFAVNAIGVSQPSMNTKPFMP---IAPTSEPLHLIVEDVTDTTT 754
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
W P G + GY + W+ V F +++L + R+
Sbjct: 755 TLKWRPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVERCGFTVKNLPTGARILFRVVG 814
Query: 2044 RNEIGLSEPLESDEPFKV 2061
N G +EP +P +
Sbjct: 815 VNIAGRTEPATLAQPVTI 832
Score = 49.2 bits (112), Expect = 2e-04
Identities = 85/331 (25%), Positives = 127/331 (38%), Gaps = 48/331 (14%)
Query: 636 FSKKPKAQY-VDEGSDILLECRLVAIPEPDIA--WLFKGEEIVPDENISVAIESDMHMYC 692
F+KK Y VD G+ I L +V I +PD+ W G+EI P
Sbjct: 258 FTKKLDPAYQVDRGNKIKL---MVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKKR--- 311
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ-VIEPLKSMIVRQGES 751
+L I + Y V + + L + KEPP ++ PL+ V G+
Sbjct: 312 -ILTINKCTLADDAAYEVAVKDEKCFTELFV--------KEPPVLIVTPLEDQQVFVGDR 362
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPT-------KSDGDTHSITILKPKKVKDEGVYT 804
V ++ +V + W K+ + + K DG H I I +D G Y
Sbjct: 363 VEMAVEV-SEEGAQVMWMKDGVELTREDSFKARYRFKKDGKRH-ILIFSDVVQEDRGRYQ 420
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
+ + AE + VEE E + ++TVK V+ V
Sbjct: 421 VITNGGQCEAE----LIVEEKQLE------VLQDIADLTVKASEQAVFKCEVSDEKVTG- 469
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
WY+N + PS+ IT + G +LVI +V E D GDY V A S A++
Sbjct: 470 KWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPE-DEGDYTFVPDGYA-LGSLSAKLNFL 527
Query: 925 VEKVTFVK-------HLQKSYETEEGKTVIL 948
KV +V HL S +T E V++
Sbjct: 528 EIKVEYVPKQEPPKIHLDCSGKTSENAIVVV 558
Score = 48.8 bits (111), Expect = 2e-04
Identities = 53/262 (20%), Positives = 102/262 (38%), Gaps = 22/262 (8%)
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
+ W+ G E+ +++ +L ++V + G Y V+ + EA L +
Sbjct: 376 VMWMKDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIV- 434
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN---KPVKALPTK 781
E++ +V++ + + V+ E + +V + + T W KN +P K +
Sbjct: 435 ------EEKQLEVLQDIADLTVKASEQAVFKCEV-SDEKVTGKWYKNGVEVRPSKRITIS 487
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE---NAEPPLF--- 835
G H + ++ + +DEG YT + + SA + E E EPP
Sbjct: 488 HVGRFHKL-VIDDVRPEDEGDYTF-VPDGYALGSLSAKLNFLEIKVEYVPKQEPPKIHLD 545
Query: 836 -INRFQE--ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVI 892
+ E I V ++L +T P P TW + +E+ + +E T+ + +
Sbjct: 546 CSGKTSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFV 605
Query: 893 TNVDSEIDSGDYKCVASNSAGK 914
D G Y +N G+
Sbjct: 606 IESAQREDEGRYTIKVTNPVGE 627
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV----KALPTKSDGDTHSIT 790
P+ + PL +V G S L+ V G+P+P + W KN + K L T G ++
Sbjct: 1049 PKFLTPLIDRVVVAGYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLITNYQG-VLTLN 1107
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
I +P D G YT +A N G A + V P
Sbjct: 1108 IRRPSPF-DAGTYTCRAVNELGEALAECKLEVRVP 1141
Score = 43.6 bits (98), Expect = 0.008
Identities = 45/178 (25%), Positives = 76/178 (42%), Gaps = 21/178 (11%)
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNRE-GEASLPI-V 724
W G E+ P + I+++ H L I +V+ EG YT V G S +
Sbjct: 471 WYKNGVEVRPSKRITISHVGRFHK----LVIDDVRPEDEGDYTFVPDGYALGSLSAKLNF 526
Query: 725 LKIKTG---EKEPPQVIEPLK------SMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
L+IK ++EPP++ +++V G + L + G P P TW K ++
Sbjct: 527 LEIKVEYVPKQEPPKIHLDCSGKTSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVF 586
Query: 776 KALPTKSDGDTH---SITILKPKKVKDEGVYTLKAENSEGIAETS---AVITVEEPTE 827
++ + S +++ + +DEG YT+K N G S V+ V +P E
Sbjct: 587 TTTEGRTRIEKRVDCSSFVIESAQREDEGRYTIKVTNPVGEDVASIFLQVVDVPDPPE 644
Score = 41.1 bits (92), Expect = 0.042
Identities = 19/71 (26%), Positives = 33/71 (46%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ + G P P+V+W KN ++ D ++ IT + + I+ + YT A N
Sbjct: 1068 LNCAVRGHPKPKVVWMKNKMEIREDPKFLITNYQGVLTLNIRRPSPFDAGTYTCRAVNEL 1127
Query: 1652 GTSSVEVTLKV 1662
G + E L+V
Sbjct: 1128 GEALAECKLEV 1138
Score = 38.3 bits (85), Expect = 0.30
Identities = 34/133 (25%), Positives = 56/133 (42%), Gaps = 10/133 (7%)
Query: 708 YTVVAVNREGEASLPIVLKIKTGEK--EPPQVIEP--LKSMIVRQ-GESVILSAQVVGNP 762
+ VV VN G + + T + EPP++ P L+ +R+ GE + L G P
Sbjct: 810 FRVVGVNIAGRTEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKP 869
Query: 763 RPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
RP + W K P+ D ++ ++ D G Y L + E + +T+ T
Sbjct: 870 RPQVVWTKGGAPLDTSRVHVRTSDFDTVFFVRQAARSDSGEYELSVQ-IENMKDTA---T 925
Query: 822 VEEPTEENAEPPL 834
+ E A PP+
Sbjct: 926 IRIRVVEKAGPPI 938
Score = 35.1 bits (77), Expect = 2.8
Identities = 23/81 (28%), Positives = 32/81 (39%), Gaps = 4/81 (4%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G L C + P+P + W+ EI D + + L I F GT
Sbjct: 1063 GYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLIT----NYQGVLTLNIRRPSPFDAGT 1118
Query: 708 YTVVAVNREGEASLPIVLKIK 728
YT AVN GEA L+++
Sbjct: 1119 YTCRAVNELGEALAECKLEVR 1139
>BC130536-1|AAI30537.1| 1141|Homo sapiens myosin binding protein C,
fast type protein.
Length = 1141
Score = 231 bits (564), Expect = 3e-59
Identities = 187/767 (24%), Positives = 335/767 (43%), Gaps = 40/767 (5%)
Query: 1019 FIRKLQD-FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
F +KL ++V + L VEI+ + W ++G+ IKP +KY FE G R L I
Sbjct: 258 FTKKLDPAYQVDRGNKIKLMVEISDPDLTLKWFKNGQEIKPS-SKYVFENVGKKRILTIN 316
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALV 1137
++ D+ Y ++DE C E+ V E P I+T L++Q+V G++ +E+++ A V
Sbjct: 317 KCTLADDAAYEVAVKDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMAVEVSEEGAQV 376
Query: 1138 RWFKDGSEI----QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
W KDG E+ F + DGK+ L D +D G Y +C A L VEE
Sbjct: 377 MWMKDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIVEE 436
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
+ + + + V A+ A E+ DE + WYK + +++ T+ + L
Sbjct: 437 KQLEVLQDIAD-LTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITISHVGRFHKL 495
Query: 1254 IIRKCTEDDQCEYTCV------LLDAK-STTKLKVEVV--EFPPKI-VD-----YEREYR 1298
+I +D+ +YT V L AK + ++KVE V + PPKI +D E
Sbjct: 496 VIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKTSENAIV 555
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK-HTKPSIDSKSASLTIKKVENTDAGI 1357
+ G+ + L V P P W+ ++ + T+ +S I+ + D G
Sbjct: 556 VVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFVIESAQREDEGR 615
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
Y +++ N G + + ++D P PP I + + W+ P G + Y+V
Sbjct: 616 YTIKVTNPVGEDVASIFLQVVDVPDPPEAVRITSVGEDWAILVWEPPMYDGGKPVTGYLV 675
Query: 1418 EYQEIDTTEWISVKNITKTQTSIQNLKTNSS--YRFRAYAVNEVDISDASETTEYYKVIK 1475
E ++ + W+ + T+T+ ++ K Y R +AVN + +S S T+ + I
Sbjct: 676 ERKKKGSQRWMKLNFEVFTETTYESTKMIEGILYEMRVFAVNAIGVSQPSMNTKPFMPIA 735
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG-KKLKTAKATYENRXX 1534
T + + + + TT GG+ V + +G ++ A R
Sbjct: 736 PTSEPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVERCG 795
Query: 1535 XXXXXXXXXXXXXYKCIAFNDHGEVETSCVV------GIQQKPVITISNEDIKQKH--KV 1586
++ + N G E + + I + P I + ++Q + KV
Sbjct: 796 FTVKNLPTGARILFRVVGVNIAGRSEPATLAQPVTIREIAEPPKIRLPRH-LRQTYIRKV 854
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G++ + +G P P+V+W K G L+ + ++ T + +V +++ RS S +Y +
Sbjct: 855 GEQLNLVVPFQGKPRPQVVWTKGGAPLDTSR-VHVRTSDFDTVFFVRQAARSDSGEYELS 913
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKH 1706
+ + ++V +K P V+++E+ + +EW+ P DDG E+ Y ++K
Sbjct: 914 VQIENMKDTATIRIRVVEKAGPPIN-VMVKEVWGTNALVEWQAPKDDGNSEIMGYFVQKA 972
Query: 1707 EPDNNRWIKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFSEA 1752
+ W V +R+ T C + L EY FRV +N G S++
Sbjct: 973 DKKTMEWFNV--YERNRHTSCTVSDLIVGNEYYFRVYTENICGLSDS 1017
Score = 144 bits (348), Expect = 4e-33
Identities = 155/646 (23%), Positives = 268/646 (41%), Gaps = 46/646 (7%)
Query: 920 RVTIDVEK-VTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQ 977
+ ++V+K F K L +Y+ + G + L + S ++ KW+ N +EI
Sbjct: 247 KAKVEVKKSAAFTKKLDPAYQVDRGNKIKLMVEISDPDLTLKWFKNGQEIKPSSKYVFEN 306
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILE 1037
G+ D + VKD++ T L VKE + L+D +V D +
Sbjct: 307 VGKKRILTINKCTLADDAAYEVAVKDEKCFTELFVKEPPVLIVTPLEDQQVFVGDRVEMA 366
Query: 1038 VEINSETADVVWERDG-EIIKPK--KNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
VE++ E A V+W +DG E+ + K +Y F+K G L + D G Y I
Sbjct: 367 VEVSEEGAQVMWMKDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGG 426
Query: 1095 SCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQL 1154
C AE+ V E E++ + + V +A F+ E++ +W+K+G E++ S I +
Sbjct: 427 QCEAELIVEEKQLEVLQDIADLTVKASEQAVFKCEVSDEKVTGKWYKNGVEVRPSKRITI 486
Query: 1155 TIDGKKQKLKIYDCDLDDAGEY-----------SCEVG--NSKCTAILTVEEPSINFTL- 1200
+ G+ KL I D +D G+Y S ++ K + E P I+
Sbjct: 487 SHVGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCS 546
Query: 1201 --RLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKSVIEDTEKFTLISD-VKKRTLIIR 1256
I+V A L V I E V TW K V TE T I V + +I
Sbjct: 547 GKTSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFVIE 606
Query: 1257 KCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKR-GSDVTLLVDYQA 1313
+D+ YT + + + + ++VV+ P D RI G D +LV ++
Sbjct: 607 SAQREDEGRYTIKVTNPVGEDVASIFLQVVDVP----DPPEAVRITSVGEDWAILV-WEP 661
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT---DAGIYKLRL--ENNCGH 1368
+ + + +K K ++ + T E+T + +Y++R+ N G
Sbjct: 662 PMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFTETTYESTKMIEGILYEMRVFAVNAIGV 721
Query: 1369 ADVEMNVTILDKPSPPGKPNIL---EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTT 1425
+ MN +P +P L ++ ++ + W P G I Y+VEY +
Sbjct: 722 SQPSMNTKPFMPIAPTSEPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEYCLEGSE 781
Query: 1426 EWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT 1483
EW+ + + + + +++NL T + FR VN S+ + T I+E + P
Sbjct: 782 EWVPANTEPVERCGFTVKNLPTGARILFRVVGVNIAGRSEPA-TLAQPVTIREI-AEPPK 839
Query: 1484 VEKP---LKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK 1526
+ P + + E + L F G P+P+V W + G L T++
Sbjct: 840 IRLPRHLRQTYIRKVGEQLNLVVPFQGKPRPQVVWTKGGAPLDTSR 885
Score = 117 bits (281), Expect = 5e-25
Identities = 108/479 (22%), Positives = 192/479 (40%), Gaps = 35/479 (7%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKELKRSHSSKYTI 1645
G++ + I G PPP W K + I + S I+ +R +YTI
Sbjct: 559 GNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFVIESAQREDEGRYTI 618
Query: 1646 EASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEK 1705
+ +N G + L+V D P PE V + + + + W+PP+ DGG +T Y +E+
Sbjct: 619 KVTNPVGEDVASIFLQVVDVPDPPEA-VRITSVGEDWAILVWEPPMYDGGKPVTGYLVER 677
Query: 1706 HEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTAL 1764
+ + RW+K+ TY K+ E Y RV A N +G S+ ++ ++P +
Sbjct: 678 KKKGSQRWMKLNFEVFTETTYESTKMIEGILYEMRVFAVNAIGVSQPSMNTKPFM----P 733
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXX 1823
P+ + + + + W P + G I Y VE EG ++W
Sbjct: 734 IAPTSEPLHLIVEDVTDTTTTLKWRPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVER 793
Query: 1824 A--RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS 1881
++ L FR+ N G S P T +TI + PP + ++ R
Sbjct: 794 CGFTVKNLPTGARILFRVVGVNIAGRSEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRK 853
Query: 1882 VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIV-TVGGSVHEHCIENIKEKD-EIIFR 1939
V G + N ++ F +GK ++V T GG+ + +++ D + +F
Sbjct: 854 V-----------GEQL-NLVVPF---QGKPRPQVVWTKGGAPLDTSRVHVRTSDFDTVFF 898
Query: 1940 I-------SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW 1992
+ S E + V + + + + P + ++ V + W P+
Sbjct: 899 VRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPPINVMVKEVWGTNALVEWQAPKD 958
Query: 1993 DGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSE 2051
DG + ++GY + D W V + + +T + DL + Y R+Y N GLS+
Sbjct: 959 DGNSEIMGYFVQKADKKTMEWFNVYERNRHT-SCTVSDLIVGNEYYFRVYTENICGLSD 1016
Score = 88.2 bits (209), Expect = 3e-16
Identities = 103/431 (23%), Positives = 165/431 (38%), Gaps = 42/431 (9%)
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT---LKV 1662
WYKNG ++ K I+ + + I +++ YT A + S ++ +KV
Sbjct: 471 WYKNGVEVRPSKRITISHVGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKV 530
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR- 1721
P K E P I + S + T E + G +I P W+K +V
Sbjct: 531 EYVP-KQEPPKIHLDCSGK--TSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFTT 587
Query: 1722 -----------DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
D ++ I+ E + + NPVG E + +DVP
Sbjct: 588 TEGRTRIEKRVDCSSFVIESAQREDEGRYTIKVTNPVG-----EDVASIFLQVVDVPD-P 641
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARIQ-- 1827
+ + + W P +GG P+ Y VE K++G ++W +
Sbjct: 642 PEAVRITSVGEDWAILVWEPPMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFTETTYEST 701
Query: 1828 KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWT 1887
K+ Y+ R++A N IG S P + + P S+P + +V + T + TLKW
Sbjct: 702 KMIEGILYEMRVFAVNAIGVSQPSMNTKPF---MPIAPTSEPLHLIVEDVTDTTTTLKWR 758
Query: 1888 EPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
P G I Y++E+ + W T ++N+ I+FR+ N G
Sbjct: 759 PPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVERCGFTVKNLPTGARILFRVVGVNIAG 818
Query: 1948 VSLP-TESQSVRLEKHATVPS----PPTAPLEIRMVGS--NIVMTSWGTPE----W-DGG 1995
S P T +Q V + + A P IR VG N+V+ G P W GG
Sbjct: 819 RSEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKPRPQVVWTKGG 878
Query: 1996 APLLGYNIAIR 2006
APL + +R
Sbjct: 879 APLDTSRVHVR 889
Score = 80.6 bits (190), Expect = 6e-14
Identities = 69/309 (22%), Positives = 124/309 (40%), Gaps = 25/309 (8%)
Query: 1282 EVVEFPPKIV---DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK-HTKPS 1337
E+ E PPKI + Y K G + L+V +Q P+P W + + H + S
Sbjct: 833 EIAE-PPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKPRPQVVWTKGGAPLDTSRVHVRTS 891
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
+++ +D+G Y+L ++ + + +++K PP + E+ ++
Sbjct: 892 --DFDTVFFVRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPPINVMVKEVWGTNA 949
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK-TQTSIQNLKTNSSYRFRAYAV 1456
+ W P++ GNS I+ Y V+ + T EW +V + T ++ +L + Y FR Y
Sbjct: 950 LVEWQAPKDDGNSEIMGYFVQKADKKTMEWFNVYERNRHTSCTVSDLIVGNEYYFRVYTE 1009
Query: 1457 NEVDISDASETTEYYKVIKETKI-------------QSPTVEKPLKNITTEPNEDIELTC 1503
N +SD+ ++ I +T I +P PL + L C
Sbjct: 1010 NICGLSDSPGVSKNTARILKTGITFKPFEYKEHDFRMAPKFLTPLIDRVVVAGYSAALNC 1069
Query: 1504 IFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
G P+PKV W ++ ++ K Y+ Y C A N+ GE
Sbjct: 1070 AVRGHPKPKVVWMKNKMEIREDPKFLITNYQGVLTLNIRRPSPFDAGTYTCRAVNELGEA 1129
Query: 1560 ETSCVVGIQ 1568
C + ++
Sbjct: 1130 LAECKLEVR 1138
Score = 62.5 bits (145), Expect = 2e-08
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 6/136 (4%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTS 1986
IE+ + +DE + I N VG + S+ L+ VP PP A + I VG + +
Sbjct: 605 IESAQREDEGRYTIKVTNPVGEDVA----SIFLQV-VDVPDPPEA-VRITSVGEDWAILV 658
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P +DGG P+ GY + + WM++ + + E Y +R++A N
Sbjct: 659 WEPPMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFTETTYESTKMIEGILYEMRVFAVNA 718
Query: 2047 IGLSEPLESDEPFKVI 2062
IG+S+P + +PF I
Sbjct: 719 IGVSQPSMNTKPFMPI 734
Score = 58.8 bits (136), Expect = 2e-07
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 1/96 (1%)
Query: 508 MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
MAP F+ L + G + C V G+P+P++ W + I+ F + + V T
Sbjct: 1046 MAPKFLTPLIDRVVVAGYSAALNCAVRGHPKPKVVWMKNKMEIREDPKF-LITNYQGVLT 1104
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
L IR P DAGT+TC A N G A + +L V P
Sbjct: 1105 LNIRRPSPFDAGTYTCRAVNELGEALAECKLEVRVP 1140
Score = 54.4 bits (125), Expect = 4e-06
Identities = 44/198 (22%), Positives = 74/198 (37%), Gaps = 7/198 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P ++ L W P +GG P+T Y++E K + W K+ + E
Sbjct: 639 PDPPEAVRITSVGEDWAILVWEPPMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFT--ET 696
Query: 1926 CIENIKEKDEIIF--RISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
E+ K + I++ R+ A N +GVS P+ + + P+ L + V
Sbjct: 697 TYESTKMIEGILYEMRVFAVNAIGVSQPSMNTKPFMP---IAPTSEPLHLIVEDVTDTTT 753
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
W P G + GY + W+ V F +++L + R+
Sbjct: 754 TLKWRPPNRIGAGGIDGYLVEYCLEGSEEWVPANTEPVERCGFTVKNLPTGARILFRVVG 813
Query: 2044 RNEIGLSEPLESDEPFKV 2061
N G SEP +P +
Sbjct: 814 VNIAGRSEPATLAQPVTI 831
Score = 48.4 bits (110), Expect = 3e-04
Identities = 85/331 (25%), Positives = 127/331 (38%), Gaps = 49/331 (14%)
Query: 636 FSKKPKAQY-VDEGSDILLECRLVAIPEPDIA--WLFKGEEIVPDENISVAIESDMHMYC 692
F+KK Y VD G+ I L +V I +PD+ W G+EI P
Sbjct: 258 FTKKLDPAYQVDRGNKIKL---MVEISDPDLTLKWFKNGQEIKPSSKYVFENVGKKR--- 311
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ-VIEPLKSMIVRQGES 751
+L I + Y V + + L + KEPP ++ PL+ V G+
Sbjct: 312 -ILTINKCTLADDAAYEVAVKDEKCFTELFV--------KEPPVLIVTPLEDQQVFVGDR 362
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPT-------KSDGDTHSITILKPKKVKDEGVYT 804
V ++ +V + W K+ + + K DG H I I +D G Y
Sbjct: 363 VEMAVEV-SEEGAQVMWMKDGVELTREDSFKARYRFKKDGKRH-ILIFSDVVQEDRGRYQ 420
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
+ + AE + VEE E + ++TVK V+ V
Sbjct: 421 VITNGGQCEAE----LIVEEKQLE------VLQDIADLTVKASEQAVFKCEVSDEKVTG- 469
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
WY+N + PS+ IT + G +LVI +V E D GDY V A S A++
Sbjct: 470 KWYKNGVEVRPSKRITISHVGRFHKLVIDDVRPE-DEGDYTFVPDGYA--LSLSAKLNFL 526
Query: 925 VEKVTFVK-------HLQKSYETEEGKTVIL 948
KV +V HL S +T E V++
Sbjct: 527 EIKVEYVPKQEPPKIHLDCSGKTSENAIVVV 557
Score = 48.0 bits (109), Expect = 4e-04
Identities = 49/260 (18%), Positives = 102/260 (39%), Gaps = 19/260 (7%)
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
+ W+ G E+ +++ +L ++V + G Y V+ + EA L +
Sbjct: 376 VMWMKDGVELTREDSFKARYRFKKDGKRHILIFSDVVQEDRGRYQVITNGGQCEAELIV- 434
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN---KPVKALPTK 781
E++ +V++ + + V+ E + +V + + T W KN +P K +
Sbjct: 435 ------EEKQLEVLQDIADLTVKASEQAVFKCEV-SDEKVTGKWYKNGVEVRPSKRITIS 487
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAEN-SEGIAETSAVITVEEPTEENAEPPLF----I 836
G H + ++ + +DEG YT + + ++ + ++ EPP
Sbjct: 488 HVGRFHKL-VIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCS 546
Query: 837 NRFQE--ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITN 894
+ E I V ++L +T P P TW + +E+ + +E T+ + +
Sbjct: 547 GKTSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEGRTRIEKRVDCSSFVIE 606
Query: 895 VDSEIDSGDYKCVASNSAGK 914
D G Y +N G+
Sbjct: 607 SAQREDEGRYTIKVTNPVGE 626
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV----KALPTKSDGDTHSIT 790
P+ + PL +V G S L+ V G+P+P + W KN + K L T G ++
Sbjct: 1048 PKFLTPLIDRVVVAGYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLITNYQG-VLTLN 1106
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
I +P D G YT +A N G A + V P
Sbjct: 1107 IRRPSPF-DAGTYTCRAVNELGEALAECKLEVRVP 1140
Score = 44.0 bits (99), Expect = 0.006
Identities = 44/177 (24%), Positives = 75/177 (42%), Gaps = 20/177 (11%)
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPI-VL 725
W G E+ P + I+++ H L I +V+ EG YT V S + L
Sbjct: 471 WYKNGVEVRPSKRITISHVGRFHK----LVIDDVRPEDEGDYTFVPDGYALSLSAKLNFL 526
Query: 726 KIKTG---EKEPPQVIEPLK------SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
+IK ++EPP++ +++V G + L + G P P TW K ++
Sbjct: 527 EIKVEYVPKQEPPKIHLDCSGKTSENAIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFT 586
Query: 777 ALPTKSDGDTH---SITILKPKKVKDEGVYTLKAENSEGIAETS---AVITVEEPTE 827
++ + S +++ + +DEG YT+K N G S V+ V +P E
Sbjct: 587 TTEGRTRIEKRVDCSSFVIESAQREDEGRYTIKVTNPVGEDVASIFLQVVDVPDPPE 643
Score = 41.1 bits (92), Expect = 0.042
Identities = 19/71 (26%), Positives = 33/71 (46%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ + G P P+V+W KN ++ D ++ IT + + I+ + YT A N
Sbjct: 1067 LNCAVRGHPKPKVVWMKNKMEIREDPKFLITNYQGVLTLNIRRPSPFDAGTYTCRAVNEL 1126
Query: 1652 GTSSVEVTLKV 1662
G + E L+V
Sbjct: 1127 GEALAECKLEV 1137
Score = 38.7 bits (86), Expect = 0.23
Identities = 34/133 (25%), Positives = 57/133 (42%), Gaps = 10/133 (7%)
Query: 708 YTVVAVNREGEASLPIVLKIKTGEK--EPPQVIEP--LKSMIVRQ-GESVILSAQVVGNP 762
+ VV VN G + + + T + EPP++ P L+ +R+ GE + L G P
Sbjct: 809 FRVVGVNIAGRSEPATLAQPVTIREIAEPPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKP 868
Query: 763 RPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
RP + W K P+ D ++ ++ D G Y L + E + +T+ T
Sbjct: 869 RPQVVWTKGGAPLDTSRVHVRTSDFDTVFFVRQAARSDSGEYELSVQ-IENMKDTA---T 924
Query: 822 VEEPTEENAEPPL 834
+ E A PP+
Sbjct: 925 IRIRVVEKAGPPI 937
Score = 35.1 bits (77), Expect = 2.8
Identities = 23/81 (28%), Positives = 32/81 (39%), Gaps = 4/81 (4%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G L C + P+P + W+ EI D + + L I F GT
Sbjct: 1062 GYSAALNCAVRGHPKPKVVWMKNKMEIREDPKFLIT----NYQGVLTLNIRRPSPFDAGT 1117
Query: 708 YTVVAVNREGEASLPIVLKIK 728
YT AVN GEA L+++
Sbjct: 1118 YTCRAVNELGEALAECKLEVR 1138
>AK056557-1|BAB71216.1| 1252|Homo sapiens protein ( Homo sapiens cDNA
FLJ31995 fis, clone NT2RP7009236, weakly similar to
BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN
CORE ).
Length = 1252
Score = 217 bits (530), Expect = 4e-55
Identities = 275/1202 (22%), Positives = 469/1202 (39%), Gaps = 101/1202 (8%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 42 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSS---AK 98
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 99 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 153
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 154 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 196
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
+ S +KIT + G Y VA+N G + + L + PP++
Sbjct: 197 RHTFLPSGS------MKITETRTSDSGMYLCVAINIAGNVTQAVKLNVHV----PPKIQR 246
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
K + V+ G+ V + G P P ITW K + + + D
Sbjct: 247 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSD 306
Query: 800 EGVYTLKAENSEGIAETSAVITVEEP-TEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT A N G ET + V+EP T E+ EPP + FQE ++ A+ T
Sbjct: 307 AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP-YNTTFQERVANQRIEFPCPAKGT- 364
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P P+I W N ++ E + + LVI +V + D+G+Y CVA N AG +
Sbjct: 365 -PKPTIKWLHNGRELTGREPGISILEDGTL-LVIASV-TPYDNGEYICVAVNEAGTTERK 421
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVST--KWYHNKKEISGMDHREII 976
+ + V V K + + L C+ T S WY + +++ + +
Sbjct: 422 YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 481
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC-IVKDQETSTMLVVKETI--PEFIRKLQDFEVK---E 1030
GR D G C + TS + + P I EV
Sbjct: 482 NNGRILKLFRATPE--DAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLN 539
Query: 1031 KDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
+DVA LE ++ D+ W +DG+ + + RG + L+++N +D+G Y C
Sbjct: 540 RDVA-LECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQC 596
Query: 1090 ILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG 1143
+ + + + + +PP I ++ + ++E T+G + + W+KDG
Sbjct: 597 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 656
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
I S+ L ID K Q L I + D+ Y+C V N TA E S + + +P
Sbjct: 657 QPIMSSSQA-LYID-KGQYLHIPRAQVSDSATYTCHVANVAGTA-----EKSFHVDVYVP 709
Query: 1204 EFI----LVPANTDAY----LTVEIP---DETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
I P N LT+E + + +TW K ++ + + + KK
Sbjct: 710 PMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK-- 767
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDY-EREYRIKRGSDVTLL-V 1309
L I E D+ +Y CV ++K EV V PP I E Y I +++ L
Sbjct: 768 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 827
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + +++ + K ++ + + +V NT G+Y+ N G
Sbjct: 828 HVTGSPPPTIMWLKDGQLVDERDGFKILLNGRKLVIAQAQVSNT--GLYRCMAANTAGDH 885
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
E VT+ P+ + + N + I ++ + Q ++T +
Sbjct: 886 KEEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG-- 943
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
N+ K Q+S + L+ + A V + A ET ++ ++ + P++E K
Sbjct: 944 --NL-KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH---EPPSLEDAGK 997
Query: 1490 --NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXX 1546
N T + ++L C G P P +TWY+D + L + T+ NR
Sbjct: 998 MLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDA 1057
Query: 1547 X-YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
YKC+A N G E + + P I+ SN + V + + GIP P +
Sbjct: 1058 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVV--VNNPVRLECEARGIPAPSLT 1115
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W K+G+ + + + ++ + + S + +YT A N AG ++ L+VY
Sbjct: 1116 WLKDGSPVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 1174
Query: 1666 PS 1667
P+
Sbjct: 1175 PN 1176
Score = 188 bits (458), Expect = 2e-46
Identities = 243/1100 (22%), Positives = 417/1100 (37%), Gaps = 85/1100 (7%)
Query: 591 FASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSD 650
F S + I E SD G + V + +PP + PK V G
Sbjct: 200 FLPSGSMKITETRTSDSGMYLCVAINIAGNVTQA-VKLNVHVPPKIQRGPKHLKVQVGQR 258
Query: 651 ILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTV 710
+ + C P P I W G ++ D V+ L I G YT
Sbjct: 259 VDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD------GTLSIDQATPSDAGIYTC 312
Query: 711 VAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQ---GESVILSAQVVGNPRPT 765
VA N G I L ++ EPP V +EP + ++ + + G P+PT
Sbjct: 313 VATNIAGTDETEITLHVQ----EPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPT 368
Query: 766 ITWCKNNKPVKAL-PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
I W N + + P S + ++ ++ D G Y A N G E + V
Sbjct: 369 IKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV 428
Query: 825 PTEENAEPPLFINRFQ--EITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
P P+ ++ Q ++V L V P P I WY++N ++ S TI
Sbjct: 429 P-------PVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTV 481
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
+G ++L + D+G Y C A N AG S + + V +
Sbjct: 482 NNGRILKLFRATPE---DAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVL 538
Query: 943 GKTVILECQTSHTV--STKWYHNKKEIS-GMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
+ V LECQ T W+ + K + G + E++ G+ D G +C
Sbjct: 539 NRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRN--DKGRYQC 596
Query: 1000 IVKDQETSTMLVVKETI--PEFIRK---LQDFEVKEKDVAILEVEINS-ETADVVWERDG 1053
V + +K TI P I+ D V + LE E + W +DG
Sbjct: 597 TVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDG 656
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEII 1110
+ I +K + L+I V D Y+C + + + TAE + V +PP I
Sbjct: 657 QPIMSSSQALYIDKGQY---LHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIE 713
Query: 1111 TRLQ---NQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
L N++V + T E + + ++ W KDG ++ +++I++ GKK L+I
Sbjct: 714 GNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK--LEIM 771
Query: 1167 DCDLDDAGEYSC---EVGNSKCTA--ILTVEEPSINFTLRLPEFILVPANT---DAYLTV 1218
D G+Y C V K + + P+I FI++ N D ++T
Sbjct: 772 SAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTG 831
Query: 1219 EIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK 1278
P + W K ++++ + F ++ + +K L+I + + Y C+ + K
Sbjct: 832 SPPPT---IMWLKDGQLVDERDGFKILLNGRK--LVIAQAQVSNTGLYRCMAANTAGDHK 886
Query: 1279 LKVEV-VEFPPKIVDYEREYRIK-RGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
+ EV V PP I R+ + V L P P+ W+ + + + +
Sbjct: 887 EEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNL- 945
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS 1396
I S L I K DAG Y N G + + + + PS +L
Sbjct: 946 KIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLV 1005
Query: 1397 INICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA 1455
N E + GN +I + + + + + ++ N + I++ + + + ++ A
Sbjct: 1006 SNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI-IDIESAQISDAGIYKCVA 1064
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
+N A T +Y + +P++ + N + L C G+P P +TW
Sbjct: 1065 INS-----AGATELFYSLQVHV---APSISGSNNMVAVVVNNPVRLECEARGIPAPSLTW 1116
Query: 1516 YRDGKKLKT---AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+DG + + Y C+A N GE + + + P
Sbjct: 1117 LKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPN 1176
Query: 1573 ITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
I +++ E L + + IPPP + W K+G+ L K+ ++ E SV++I
Sbjct: 1177 IMGEEQNVSVLISQAVELLCQS--DAIPPPTLTWLKDGHPLL--KKPGLSISENRSVLKI 1232
Query: 1633 KELKRSHSSKYTIEASNTAG 1652
++ + + +YT EA+N AG
Sbjct: 1233 EDAQVQDTGRYTCEATNVAG 1252
Score = 177 bits (430), Expect = 5e-43
Identities = 247/1143 (21%), Positives = 444/1143 (38%), Gaps = 115/1143 (10%)
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA-PLSDHGSEMTVXXXXXXXXXXXX 625
+L I V +D G +TCVA N AG + TT ++V P HG ++
Sbjct: 15 SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQI-------------- 60
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
+EGIP T L C+ P+P + W KG E++ + +
Sbjct: 61 LSTIEGIPVT-----------------LPCKASGNPKPSVIWSKKG-ELISTSSAKFSAG 102
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT-----GEKEPPQVIEP 740
+D +Y + + + G Y A N G A + L + G++ +P
Sbjct: 103 ADGSLY-----VVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKP 157
Query: 741 LKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDE 800
++ + V GE V L +V P P ITW K + + + + + D
Sbjct: 158 VE-ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDS 216
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
G+Y A N G + + V P + P + ++ V ++ I A+ T P
Sbjct: 217 GMYLCVAINIAGNVTQAVKLNVHVPPKIQRGP-----KHLKVQVGQRVDIPCNAQGT--P 269
Query: 861 VPSITWYR-NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
+P ITW + + ++ E N DG L I + D+G Y CVA+N AG
Sbjct: 270 LPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQA-TPSDAGIYTCVATNIAGTDE--T 323
Query: 920 RVTIDVEKVTFVKHLQKSYETE-----EGKTVILECQTSHT--VSTKWYHNKKEISGMDH 972
+T+ V++ V+ L+ Y T + + C T + KW HN +E++G +
Sbjct: 324 EITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREP 383
Query: 973 R-EIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDF 1026
I+++G D G C+ ++ T +K +P I+ ++ +
Sbjct: 384 GISILEDG--TLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNV 441
Query: 1027 EVKEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEG 1085
V + L E+ + ++ W +D + + + G I KL+ + D G
Sbjct: 442 SVLLNQLTNLFCEVEGTPSPIIMWYKD-NVQVTESSTIQTVNNGRILKLF--RATPEDAG 498
Query: 1086 EYSCILRDESCTAEVTV---VELPPEII-TRLQNQ-KVNKGNKATFEIELTKGDAL--VR 1138
YSC + + T++ V +PP II T N+ V E ++ KG +
Sbjct: 499 RYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV-KGTPFPDIH 557
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAI----LTVEEP 1194
WFKDG + F + + + Q L + + +D G Y C V N+ LT+ P
Sbjct: 558 WFKDGKPL-FLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIP 616
Query: 1195 SINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKKRTL 1253
+ I V N+ L E + +TWYK I + + I K + L
Sbjct: 617 PSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYID--KGQYL 674
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKR----GSDVTLLV 1309
I + D YTC + + T + V + P +++ + + +TL
Sbjct: 675 HIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLEC 734
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W+ + +K + + I++ L I + D G Y + G
Sbjct: 735 KAAGNPSPILTWLKDGVPVKANDNIR--IEAGGKKLEIMSAQEIDRGQYICVATSVAGEK 792
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWI 1428
+++ V +L P+ G N+ + TG+ I ++ + Q +D +
Sbjct: 793 EIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLVDERDGF 852
Query: 1429 SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP- 1487
+ + + I + +++ +R A N A + E ++V T PT++
Sbjct: 853 KIL-LNGRKLVIAQAQVSNTGLYRCMAAN-----TAGDHKEEFEV---TVHVPPTIKSSG 903
Query: 1488 LKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXX---XXXXXXXXXX 1544
L + + L CI G+P P +TW +D + + TA+ + +
Sbjct: 904 LSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLED 963
Query: 1545 XXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV 1604
Y C+A N GE + + + + P + + + + + V + + G P P +
Sbjct: 964 AGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVI 1023
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD 1664
WYK+ L ++T + +I I+ + S + Y A N+AG + + +L+V+
Sbjct: 1024 TWYKDNRLLSGST--SMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHV 1081
Query: 1665 KPS 1667
PS
Sbjct: 1082 APS 1084
Score = 163 bits (396), Expect = 6e-39
Identities = 237/1069 (22%), Positives = 403/1069 (37%), Gaps = 93/1069 (8%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
PKH G V C +G P P ITW + + + + + D TL I + P
Sbjct: 248 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD---GTLSIDQATP 304
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPT 635
DAG +TCVA N AG + L V+ P TV D+ T
Sbjct: 305 SDAGIYTCVATNIAGTDETEITLHVQEP-------PTVE------------DLEPPYNTT 345
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F ++ Q ++ C P+P I WL G E+ E ++I D ++L
Sbjct: 346 FQERVANQRIE------FPCPAKGTPKPTIKWLHNGRELTGREP-GISILEDG----TLL 394
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI--EPLKSMIVRQGESVI 753
I +V + G Y VAVN G LK+ PP + E + ++ V +
Sbjct: 395 VIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV----PPVIKDKEQVTNVSVLLNQLTN 450
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L +V G P P I W K+N V T + I L +D G Y+ KA N G
Sbjct: 451 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGRILKLFRATPEDAGRYSCKAINIAGT 510
Query: 814 AETSAVITVEEPTEENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
++ I V P P + F E++V + L +V P P I W+++ +
Sbjct: 511 SQKYFNIDVLVP------PTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 564
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ + + D + L + N D G Y+C SN+AGK + ++TI +
Sbjct: 565 LFLGDPNVELLDRGQV-LHLKNARRN-DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGG 622
Query: 933 HLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ + LEC+T + WY + + I I +G+
Sbjct: 623 NVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 682
Query: 991 XXDVGVIKCIVKDQETST--MLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-- 1046
D C V + + V +P I + ++ V + + + A
Sbjct: 683 --DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNP 740
Query: 1047 ---VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
+ W +DG +K N E G +KL I + D G+Y C+ + E+
Sbjct: 741 SPILTWLKDGVPVKANDN-IRIEAGG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYE 797
Query: 1103 --VELPPEIITRLQNQK--VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
V +PP I + V N + +T + W KDG + + ++ ++
Sbjct: 798 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLVDERDGFKILLN 857
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLRLPEFILVPANTD 1213
G+K L I + + G Y C N+ K +TV P + L E ++V
Sbjct: 858 GRK--LVIAQAQVSNTGLYRCMAANTAGDHKEEFEVTVHVPPTIKSSGLSERVVVKYKPV 915
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
A + +TW K + +T + L R L I K +D YTCV +A
Sbjct: 916 ALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNA 974
Query: 1274 KSTTKLKVEV-VEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
T+ +++ V PP + D + + + V L P P W +++++
Sbjct: 975 AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSG 1034
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
T + ++ + I+ + +DAGIYK N+ G ++ ++ + PS G N++
Sbjct: 1035 S--TSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMV 1092
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ ++ E ++ + + + V + + ++ + + + + R
Sbjct: 1093 AVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQISDTGR 1151
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ AVN E + I P + +N++ ++ +EL C +P
Sbjct: 1152 YTCVAVNAAG--------EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPP 1203
Query: 1511 PKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG 1557
P +TW +DG L K + ENR Y C A N G
Sbjct: 1204 PTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG 1252
Score = 162 bits (394), Expect = 1e-38
Identities = 221/1023 (21%), Positives = 400/1023 (39%), Gaps = 77/1023 (7%)
Query: 695 LKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I V+ G YT VA N G + +V+ + + Q++ + +G V
Sbjct: 16 LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI------EGIPV 69
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYTLKAENSE 811
L + GNP+P++ W K + + K S G S+ ++ P ++ G Y A N+
Sbjct: 70 TLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYVCTATNTA 128
Query: 812 GIAETSAVITVE-EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G A+ +TV P + L ++ EI+V + L V P P ITW +
Sbjct: 129 GYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKET 188
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
++ISP ++++ T DSG Y CVA N AG + ++ + V
Sbjct: 189 QLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVAINIAGNVTQAVKLNVHVPPK-- 243
Query: 931 VKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXX 990
++ K + + G+ V + C T +K + + E
Sbjct: 244 IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQAT 303
Query: 991 XXDVGVIKCIVKD----QETSTMLVVKETIPEFIRKLQD--FEVKEKDVAILEVEI---- 1040
D G+ C+ + ET L V+E P + L+ ++ VA +E
Sbjct: 304 PSDAGIYTCVATNIAGTDETEITLHVQE--PPTVEDLEPPYNTTFQERVANQRIEFPCPA 361
Query: 1041 -NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
+ + W +G + ++ + G + L I + + +D GEY C+ +E+ T E
Sbjct: 362 KGTPKPTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAVNEAGTTE 419
Query: 1100 VTV---VELPPEIITRLQNQKV----NKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
V +PP I + Q V N+ E+E T ++ W+KD ++ S+ I
Sbjct: 420 RKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSP-IIMWYKDNVQVTESSTI 478
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPEFILV 1208
Q +G+ LK++ +DAG YSC+ G S+ + V P P + V
Sbjct: 479 QTVNNGRI--LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV 536
Query: 1209 PANTDAYLTVEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
N D L ++ D+ W+K + + + D + + L ++ +D+ Y
Sbjct: 537 VLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD-RGQVLHLKNARRNDKGRYQ 595
Query: 1268 CVLLDAKSTTKLKVEV-VEFPPKIV--DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
C + +A +++ + PP I + + + S + L + + P P W +
Sbjct: 596 CTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKD 655
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+ I ID K L I + + +D+ Y + N G A+ +V + P
Sbjct: 656 GQPIMSSSQAL-YID-KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIE 713
Query: 1385 GKPNILEIDSSSINICWD---EPENTGN-STIIYYVVEYQEIDTTEWISVKNITKTQTSI 1440
G N+ + + I E + GN S I+ ++ + + + I + +
Sbjct: 714 G--NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRI------EAGG 765
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE--KPLKNITTEPNED 1498
+ L+ S+ V S A E Y+V + P +E N
Sbjct: 766 KKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV---DVLVPPAIEGGDETSYFIVMVNNL 822
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDH 1556
+EL C G P P + W +DG+ + + N Y+C+A N
Sbjct: 823 LELDCHVTGSPPPTIMWLKDGQLVDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTA 882
Query: 1557 GEVETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE 1614
G+ + V + P I S +E + K+K + + GIP P + W K+ +
Sbjct: 883 GDHKEEFEVTVHVPPTIKSSGLSERVVVKYK---PVALQCIANGIPNPSITWLKDDQPV- 938
Query: 1615 NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI 1674
N + N+ + V++I + + +YT A+N AG + + L V++ PS + +
Sbjct: 939 NTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKM 998
Query: 1675 MRE 1677
+ E
Sbjct: 999 LNE 1001
Score = 47.6 bits (108), Expect = 5e-04
Identities = 44/203 (21%), Positives = 77/203 (37%), Gaps = 14/203 (6%)
Query: 469 VPAQYLMDENNYTQYLQKKLN--EKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGST 526
+P + D YT ++ EK + V+ P E P+ K +
Sbjct: 676 IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL------NKQVVIAHS 729
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ EC+ G P P +TW + +K + + ++ + + +E+ D G + CVA
Sbjct: 730 LTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEI---DRGQYICVAT 786
Query: 587 NAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYV 645
+ AG E+ ++ P + G E + + PPT Q V
Sbjct: 787 SVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLV 846
Query: 646 DE--GSDILLECRLVAIPEPDIA 666
DE G ILL R + I + ++
Sbjct: 847 DERDGFKILLNGRKLVIAQAQVS 869
>X64698-1|CAA45939.1| 1100|Homo sapiens titin protein.
Length = 1100
Score = 214 bits (522), Expect = 3e-54
Identities = 171/613 (27%), Positives = 266/613 (43%), Gaps = 37/613 (6%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT 1438
D P P PNI+++ S+++ W +P+ TG S I Y +E++E ++ W K KT
Sbjct: 81 DVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLW---KRANKTPI 137
Query: 1439 SIQNLKTNS-----SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITT 1493
+++ K Y FR A+N + S +E V+ I P + + NIT
Sbjct: 138 RMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSE--PVVALDPIDPPGKPEVI-NITR 194
Query: 1494 EPNEDIELTCIFGGVPQPKVTWY----RDGKKLKTAKATYENRXXXXXXXXXXXXXXXY- 1548
I + G K+T Y RD KA + N Y
Sbjct: 195 NSVTLIWTEPKYDG--GHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYE 252
Query: 1549 -KCIAFNDHGEV-------ETSCVVGIQQKPVITISNEDIKQ--KHKVGDEWLVTAV-IE 1597
+ A N G + ET + P I + + IK K GD ++ A+ I
Sbjct: 253 FRIRAKNTAGAISAPSESTETIICKDEYEAPTIVL-DPTIKDGLTIKAGDTIVLNAISIL 311
Query: 1598 GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVE 1657
G P P+ W K G + IT+ +S++ IK R + +YTI A+N GT
Sbjct: 312 GKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH 371
Query: 1658 VTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA 1717
V + V D P P GPV + +S E T+ W PPL+DGG + Y +EK E W V+
Sbjct: 372 VKVTVLDVPGPP-GPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVS 430
Query: 1718 DVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXX 1777
+ D + KL + EY+FRV A N G E ++SEP+ + P
Sbjct: 431 E-DIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSN 489
Query: 1778 XIDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXXXXXXXXAR--IQKLSINTT 1834
N + ++W +GGS I Y VE ++ + +W R + L +T
Sbjct: 490 VTKNTAT-VSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGST 548
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
Y+FR+ A N G P + D + + PP P N V+++T +S +L W +P +GG
Sbjct: 549 YEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHIDGG 608
Query: 1895 SPITNYIIEFKTVKGKSWTKIVT-VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
IT Y++E + V ++W K T + + + +++ K++ FRISA N GV P
Sbjct: 609 LEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAV 668
Query: 1954 SQSVRLEKHATVP 1966
V + + P
Sbjct: 669 IPDVEIVEREMAP 681
Score = 193 bits (470), Expect = 7e-48
Identities = 190/798 (23%), Positives = 323/798 (40%), Gaps = 45/798 (5%)
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT--KLKVEVVE 1285
+W K I ++ + S L I+ T D EYT + T +KV V++
Sbjct: 319 SWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD 378
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
P E + +T + P +I+ + + T S D +S
Sbjct: 379 VPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRH 438
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEMN--VTILDK---PSPPGKPNILEIDSSSINIC 1400
K+ + I+++ N+ G + + V ++D+ P PP KP + + ++ +
Sbjct: 439 VATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVS 498
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI-SVKN-ITKTQTSIQNLKTNSSYRFRAYAVNE 1458
W P + G S I Y VE +E + W+ ++K ++ + + L+ S+Y FR A N
Sbjct: 499 WKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENR 558
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIEL--TCIFGGVPQPKVTWY 1516
I SE ++ ++K+ P TT+ + + I GG+ ++T Y
Sbjct: 559 AGIGPPSEASDSV-LMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHIDGGL---EITGY 614
Query: 1517 -------RDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV--VGI 1567
D +K T ++ A ND G E + + V I
Sbjct: 615 VVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEI 674
Query: 1568 QQKPVITISNEDIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITT 1623
++ + D + + + G + I+G P PEV W K+ L+N NI
Sbjct: 675 VEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKN--RANIEN 732
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV 1683
E +++ I E R + K+ + N AG S V ++V D ++P + +I+++SV
Sbjct: 733 TESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDT-ARPSPQLRPTDITKDSV 791
Query: 1684 TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
T+ W PL DGG +T Y +EK E + A TY + L+E CEY FRV+A
Sbjct: 792 TLHWDLPLIDGGSRITNYIVEKREATRKSY-STATTKCHKCTYKVTGLSEGCEYFFRVMA 850
Query: 1744 QNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDY 1802
+N G E E+ EP+ A P I +V + W + +GGS I Y
Sbjct: 851 ENEYGIGEPTETTEPVKASEAPSPPDSLNIMD----ITKSTVSLAWPKPKHDGGSKITGY 906
Query: 1803 KVEIKQEGK-KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK 1861
+E +++G +W ++ L+ Y F++ A N G S P S I +
Sbjct: 907 VIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQ 966
Query: 1862 TLTPPSQPRNFVVSESTSRSV-TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG 1920
T+ P R +++ +K P P + + +K T
Sbjct: 967 TMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTAT 1026
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGS 1980
S + E ++ D + ++A N VG + ++ H +P PPT P++ V S
Sbjct: 1027 STILNINECVRS-DSGPYPLTARNIVG----EVGDVITIQVH-DIPGPPTGPIKFDEVSS 1080
Query: 1981 NIVMTSWGTPEWDGGAPL 1998
+ V SW PE DGG P+
Sbjct: 1081 DFVTFSWDPPENDGGVPI 1098
Score = 170 bits (413), Expect = 5e-41
Identities = 97/275 (35%), Positives = 141/275 (51%), Gaps = 9/275 (3%)
Query: 1684 TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
T++W PP DDGG E+T Y +EK + NN+W+ A + T+ + +L+E EY FRV A
Sbjct: 1 TLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKT-TFRVTRLHEGMEYTFRVSA 59
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
+N G E L+SEPIV + DVP + ++SV +TW +K GGSPI Y
Sbjct: 60 ENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIVD-VRHDSVSLTWTDPKKTGGSPITGYH 118
Query: 1804 VEIKQEGKK-WKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
+E K+ WK ++ L+ Y+FR+ A N G P + +
Sbjct: 119 LEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVAL 178
Query: 1861 KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG 1920
+ PP +P V T SVTL WTEP+ +GG +T YI+E + + KSW K V
Sbjct: 179 DPIDPPGKPE---VINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNV 235
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVG-VSLPTES 1954
+ ++ E + FRI A+NT G +S P+ES
Sbjct: 236 PECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSES 270
Score = 159 bits (385), Expect = 1e-37
Identities = 167/713 (23%), Positives = 274/713 (38%), Gaps = 47/713 (6%)
Query: 1375 VTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK--N 1432
V LD PPGKP ++ I +S+ + W EP+ G + Y+VE +++ + W+ N
Sbjct: 175 VVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVN 234
Query: 1433 ITKTQTSIQNLKTNSSYRFRAYAVNEVD-ISDASETTEYYKVIKETKIQSPTV--EKPLK 1489
+ + ++ +L Y FR A N IS SE+TE +I + + ++PT+ + +K
Sbjct: 235 VPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTE--TIICKDEYEAPTIVLDPTIK 292
Query: 1490 N-ITTEPNEDIELTCI-FGGVPQPKVTWYRDGKKLKTAKATY----ENRXXXXXXXXXXX 1543
+ +T + + I L I G P PK +W + GK ++ + T
Sbjct: 293 DGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRK 352
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKP----VITISNEDIKQKHKVGDEWLVTAVIEGI 1599
Y A N G V + P + ISN + K W G
Sbjct: 353 DAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAE---KATLTWTPPLEDGGS 409
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT----AGTSS 1655
P I K E + E R K ++Y S G
Sbjct: 410 PIKSYIL----EKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPV 465
Query: 1656 VEVTLKVYDK---PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR 1712
+K+ D+ P PE P + +++ + T+ WK P+DDGG E+T Y +E+ E + R
Sbjct: 466 QSEPVKMVDRFGPPGPPEKPEV-SNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLR 524
Query: 1713 WIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
W++ + L E Y FRV A+N G E+ V+ P
Sbjct: 525 WVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPS 584
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKW-KXXXXXXXXXAR--IQK 1828
+S + W +GG I Y VE ++ G + W K + +
Sbjct: 585 NPHVTDTTKKSASLAWGKPHIDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPD 644
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS-VTLKWT 1887
L Y FRI A N+ G P D + + + P + + R+ ++++
Sbjct: 645 LQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIF 704
Query: 1888 EPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
P +P + + +K ++ + S I D F ++ EN G
Sbjct: 705 VPIKGRPAPEVTWTKDNINLKNRA---NIENTESFTLLIIPECNRYDTGKFVMTIENPAG 761
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRD 2007
+ +VR+ A PSP P +I + V W P DGG+ + Y + R+
Sbjct: 762 KK--SGFVNVRVLDTAR-PSPQLRPTDIT---KDSVTLHWDLPLIDGGSRITNYIVEKRE 815
Query: 2008 VTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
T+ + + + + LSE Y R+ A NE G+ EP E+ EP K
Sbjct: 816 ATRKSY-STATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVK 867
Score = 137 bits (331), Expect = 5e-31
Identities = 156/686 (22%), Positives = 267/686 (38%), Gaps = 57/686 (8%)
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
W P++ G S I Y++E ++ +W++ + + KT + L Y FR A N+
Sbjct: 4 WAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKY 63
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI----FGGVPQPKVTW 1515
+ + ++ ++ P P NI ++ + LT GG P +T
Sbjct: 64 GVGEGLKSEP---IVARHPFDVPDAPPP-PNIVDVRHDSVSLTWTDPKKTGGSP---ITG 116
Query: 1516 Y------RDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ 1569
Y R+ K A T ++ +A N G + S +
Sbjct: 117 YHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPS----LPS 172
Query: 1570 KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND--KEYNITTKE-- 1625
+PV+ + D K +V + + + P Y G+KL ++ ++ +K
Sbjct: 173 EPVVALDPIDPPGKPEVINITRNSVTLIWTEPK----YDGGHKLTGYIVEKRDLPSKSWM 228
Query: 1626 KTSVIRIKE-------LKRSHSSKYTIEASNTAGTSSV--EVTLKVYDKPSKPEGPVIMR 1676
K + + + E L ++ I A NTAG S E T + K +++
Sbjct: 229 KANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLD 288
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN-NRWIKVADVDRDVET-----YCIQK 1730
++ +TI+ + + + + K + I+ +D+ + T I+
Sbjct: 289 PTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKY 348
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
+ + A NP G + E + + T LDVP + E +TW P
Sbjct: 349 ATRKDAGEYTITATNPFG----TKVEHVKV-TVLDVPGPPGPVEISN-VSAEKATLTWTP 402
Query: 1791 SEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQ-KLSINTTYQFRIYARNEIGTS 1848
++GGSPI Y +E ++ + W + KL Y FR+ A N G
Sbjct: 403 PLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKG 462
Query: 1849 LPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVK 1908
P S+ + + PP P VS T + T+ W P +GGS IT Y +E + K
Sbjct: 463 EPVQSEPVKMVDR-FGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKK 521
Query: 1909 GKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPS 1967
W + + S + ++E FR+SAEN G+ P+E S SV ++ A P
Sbjct: 522 SLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPG 581
Query: 1968 PPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM-EVGKVDVNTLKF 2026
PP+ P + +WG P DGG + GY + + V W+ + + +F
Sbjct: 582 PPSNP-HVTDTTKKSASLAWGKPHIDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQF 640
Query: 2027 NIRDLSENHTYMIRIYARNEIGLSEP 2052
+ DL Y RI A N+ G+ EP
Sbjct: 641 VVPDLQTKEKYNFRISAINDAGVGEP 666
Score = 128 bits (309), Expect = 2e-28
Identities = 128/538 (23%), Positives = 217/538 (40%), Gaps = 36/538 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK---TQ 1437
P PP P++ + S ++ W +P G I YVVE+Q++ WI T TQ
Sbjct: 580 PGPPSNPHVTDTTKKSASLAWGKPHIDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQ 639
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE 1497
+ +L+T Y FR A+N+ + + + + V +E + + +
Sbjct: 640 FVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGL 699
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXX-XXXXXYKCIAFNDH 1556
I + G P P+VTW +D LK +A EN K + ++
Sbjct: 700 SIRIFVPIKGRPAPEVTWTKDNINLKN-RANIENTESFTLLIIPECNRYDTGKFVMTIEN 758
Query: 1557 GEVETSCVVGIQ----QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK 1612
+ S V ++ +P + DI K V W + + G + Y +
Sbjct: 759 PAGKKSGFVNVRVLDTARPSPQLRPTDIT-KDSVTLHWDLPLIDGG---SRITNYIVEKR 814
Query: 1613 LENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS-VEVT--LKVYDKPSK 1668
K Y+ TTK ++ L + + A N G E T +K + PS
Sbjct: 815 EATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP 874
Query: 1669 PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCI 1728
P+ IM +I++ +V++ W P DGG ++T Y IE +++W + V + +E +
Sbjct: 875 PDSLNIM-DITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV-KGLECV-V 931
Query: 1729 QKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXI-----DNES 1783
+ L E EY F+V+A N G S ES P+++K +P + DN
Sbjct: 932 RNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIK 991
Query: 1784 VYITWFPSEKNGGSPIIDYKV--EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
V I K P + +K +I ++ ++ I + + + + + A
Sbjct: 992 VEIPVLGRPK----PTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTA 1047
Query: 1842 RNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
RN +G + I + PP+ P F E +S VT W PE++GG PI+N
Sbjct: 1048 RNIVGEVGDVIT---IQVHDIPGPPTGPIKF--DEVSSDFVTFSWDPPENDGGVPISN 1100
Score = 126 bits (303), Expect = 1e-27
Identities = 106/432 (24%), Positives = 181/432 (41%), Gaps = 19/432 (4%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
++ L+ + ++ + A N AG +S V +K P P + + +++S ++
Sbjct: 539 KVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASL 598
Query: 1686 EWKPPLDDGGLELTKYAIEKHEPDNNRWIK-VADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
W P DGGLE+T Y +E + + WIK + + + L +Y FR+ A
Sbjct: 599 AWGKPHIDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAI 658
Query: 1745 NPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G E A+ + +++ + + + I F K +P + +
Sbjct: 659 NDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWT 718
Query: 1804 VEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTL 1863
+ + I + + T +F + N G + + + + T
Sbjct: 719 KDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVN---VRVLDTA 775
Query: 1864 TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVH 1923
P Q R ++ T SVTL W P +GGS ITNYI+E + KS++ T
Sbjct: 776 RPSPQLRP---TDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKC- 831
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
+ + + E E FR+ AEN G+ PTE+ K + PSPP + L I + + V
Sbjct: 832 TYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEP--VKASEAPSPPDS-LNIMDITKSTV 888
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
+W P+ DGG+ + GY I + W + V L+ +R+L+E Y ++ A
Sbjct: 889 SLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHI--TTVKGLECVVRNLTEGEEYTFQVMA 946
Query: 2044 RNEIGLSEPLES 2055
N G S P ES
Sbjct: 947 VNSAGRSAPRES 958
Score = 124 bits (300), Expect = 3e-27
Identities = 83/275 (30%), Positives = 121/275 (44%), Gaps = 7/275 (2%)
Query: 1786 ITWFPSEKNGGSPIIDYKVEIKQE-GKKWKXXXXXXXXXA-RIQKLSINTTYQFRIYARN 1843
+ W P + +GGS I +Y +E + KW R+ +L Y FR+ A N
Sbjct: 2 LKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAEN 61
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
+ G S+ + P + P +V + SV+L WT+P+ GGSPIT Y +E
Sbjct: 62 KYGVGEGLKSEPIVARHPFDVPDAPPPPNIV-DVRHDSVSLTWTDPKKTGGSPITGYHLE 120
Query: 1904 FKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHA 1963
FK W + + + + + E E FR+ A N GV P+ + A
Sbjct: 121 FKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVV---A 177
Query: 1964 TVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNT 2023
P P E+ + N V W P++DGG L GY + RD+ WM+ V+V
Sbjct: 178 LDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPE 237
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIG-LSEPLESDE 2057
F + DL E Y RI A+N G +S P ES E
Sbjct: 238 CAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTE 272
Score = 119 bits (287), Expect = 1e-25
Identities = 118/478 (24%), Positives = 198/478 (41%), Gaps = 27/478 (5%)
Query: 1615 NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-----SSVEVTLKVYDKPSKP 1669
N+K + + + R+ L + + A N G S V +D P P
Sbjct: 27 NNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAP 86
Query: 1670 EGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQ 1729
P I+ ++ +SV++ W P GG +T Y +E E ++ W + + + +
Sbjct: 87 PPPNIV-DVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVT 145
Query: 1730 KLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW 1788
L E EY FRV+A N G + +L SEP+V +D P I SV + W
Sbjct: 146 GLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPG----KPEVINITRNSVTLIW 201
Query: 1789 FPSEKNGGSPIIDYKVEIKQ-EGKKWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEI 1845
+ +GG + Y VE + K W + L Y+FRI A+N
Sbjct: 202 TEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTA 261
Query: 1846 GT-SLPYTSDDKITIGKTLTPPSQPRNFVVSES-TSRSVTLKWTEPESNGGSPI--TNYI 1901
G S P S + I P+ + + + T ++ S G P+ +++
Sbjct: 262 GAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWS 321
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
K ++ T+I + S I+ KD + I+A N G T+ + V++
Sbjct: 322 KAGKDIRPSDITQITSTPTS-SMLTIKYATRKDAGEYTITATNPFG----TKVEHVKVTV 376
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV 2021
VP PP P+EI V + +W P DGG+P+ Y + R+ ++ +W V + D+
Sbjct: 377 -LDVPGPP-GPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSE-DI 433
Query: 2022 NTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
+ + L + + Y+ R+ A N G EP++S EP K++ G E E + V
Sbjct: 434 QSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQS-EPVKMVDRFGPPGPPEKPEVSNV 490
Score = 97.9 bits (233), Expect = 3e-19
Identities = 56/178 (31%), Positives = 84/178 (47%), Gaps = 6/178 (3%)
Query: 1883 TLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC--IENIKEKDEIIFRI 1940
TLKW P+ +GGS ITNYI+E + W VT +V + + + E E FR+
Sbjct: 1 TLKWAPPKDDGGSEITNYILEKRDSVNNKW---VTCASAVQKTTFRVTRLHEGMEYTFRV 57
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
SAEN GV +S+ + VP P P I V + V +W P+ GG+P+ G
Sbjct: 58 SAENKYGVGEGLKSEPIVARHPFDVPDAPPPP-NIVDVRHDSVSLTWTDPKKTGGSPITG 116
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
Y++ ++ +W K + F + L+E Y R+ A N G+ +P EP
Sbjct: 117 YHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEP 174
Score = 78.2 bits (184), Expect = 3e-13
Identities = 82/357 (22%), Positives = 150/357 (42%), Gaps = 35/357 (9%)
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTW------YKKKSVIEDTEKFTLIS 1246
P L ++V A + V I +VTW K ++ IE+TE FTL
Sbjct: 681 PDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTL-- 738
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
LII +C D ++ + + V V +++D R R +D+T
Sbjct: 739 ------LIIPECNRYDTGKFVMTIENPAGKKSGFVNV-----RVLDTARPSPQLRPTDIT 787
Query: 1307 L--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL--TIKKVENTDAG---IYK 1359
+ + P + + + I++K + T+ S + + KV G ++
Sbjct: 788 KDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFR 847
Query: 1360 LRLENNCG---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
+ EN G + V + PSPP NI++I S++++ W +P++ G S I YV
Sbjct: 848 VMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYV 907
Query: 1417 VEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+E Q + +W + + + ++NL Y F+ AVN S E+ ++KE
Sbjct: 908 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPV--IVKE 965
Query: 1477 TKIQSPTVEKPL--KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYE 1530
+ + + K + + ++I++ G P+P VTW + + LK T + +E
Sbjct: 966 QTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFE 1022
Score = 75.4 bits (177), Expect = 2e-12
Identities = 53/196 (27%), Positives = 80/196 (40%), Gaps = 3/196 (1%)
Query: 1299 IKRGSDVTL-LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGI 1357
IK G + L + P P W K I+ T+ + S+ LTIK DAG
Sbjct: 297 IKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGE 356
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
Y + N G + VT+LD P PPG I + + + W P G S I Y++
Sbjct: 357 YTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYIL 416
Query: 1418 EYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
E +E W V ++I + L + Y FR AVN + + +E K++
Sbjct: 417 EKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQ-SEPVKMVDR 475
Query: 1477 TKIQSPTVEKPLKNIT 1492
P + + N+T
Sbjct: 476 FGPPGPPEKPEVSNVT 491
Score = 59.3 bits (137), Expect = 1e-07
Identities = 41/196 (20%), Positives = 86/196 (43%), Gaps = 10/196 (5%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT---KLKVEV 1283
+T Y ++ + ++++T I+ VK ++R TE ++ + + +++ + + + +
Sbjct: 903 ITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVI 962
Query: 1284 VEFPPKIVD------YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
V+ + + Y++ K G ++ + + P+P W +I+K+ +
Sbjct: 963 VKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFE 1022
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKP-NILEIDSSS 1396
+ S L I + +D+G Y L N G + + + D P PP P E+ S
Sbjct: 1023 TTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDF 1082
Query: 1397 INICWDEPENTGNSTI 1412
+ WD PEN G I
Sbjct: 1083 VTFSWDPPENDGGVPI 1098
Score = 56.8 bits (131), Expect = 8e-07
Identities = 44/153 (28%), Positives = 76/153 (49%), Gaps = 10/153 (6%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA----SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ N+ + +E T+ V+AVN G + S P+++K +T E K +I + G+++
Sbjct: 931 VRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNI 990
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV--KDEGVYTLKAENS 810
+ V+G P+PT+TW K ++ +K + T + TIL + D G Y L A N
Sbjct: 991 KVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNI 1050
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G E VIT++ + PP +F E++
Sbjct: 1051 VG--EVGDVITIQ--VHDIPGPPTGPIKFDEVS 1079
Score = 43.2 bits (97), Expect = 0.010
Identities = 30/119 (25%), Positives = 58/119 (48%), Gaps = 7/119 (5%)
Query: 709 TVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL--KSMIVRQGESVILSA-QVVGNPRPT 765
T A++ E++ I+ K + + P V++P + ++ G++++L+A ++G P P
Sbjct: 260 TAGAISAPSESTETIICKDEY--EAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPK 317
Query: 766 ITWCKNNKPVKA--LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+W K K ++ + + T S+ +K KD G YT+ A N G +TV
Sbjct: 318 SSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTV 376
Score = 42.7 bits (96), Expect = 0.014
Identities = 25/120 (20%), Positives = 57/120 (47%), Gaps = 4/120 (3%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE-PPQV---IEPLKSMIVRQGESV 752
+ +++ ++ + + A+N G ++ ++ E+E P E ++++VR G S+
Sbjct: 642 VPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSI 701
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ + G P P +TW K+N +K + ++ ++ I+ D G + + EN G
Sbjct: 702 RIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAG 761
Score = 38.7 bits (86), Expect = 0.23
Identities = 29/129 (22%), Positives = 54/129 (41%), Gaps = 4/129 (3%)
Query: 796 KVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEP-PLFINRFQEITVKEKGTIKLVA 854
+ K++ + + A N G+ E + + VE E A L + + V+ +I++
Sbjct: 646 QTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFV 705
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+ P P +TW ++N + I E+ L+I + D+G + N AGK
Sbjct: 706 PIKGRPAPEVTWTKDNINLKNRANIENT---ESFTLLIIPECNRYDTGKFVMTIENPAGK 762
Query: 915 SSHGARVTI 923
S V +
Sbjct: 763 KSGFVNVRV 771
Score = 38.7 bits (86), Expect = 0.23
Identities = 56/251 (22%), Positives = 103/251 (41%), Gaps = 28/251 (11%)
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
T K + TY V ++ E ++ + + G EP + EP+K+ L+
Sbjct: 823 TATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDS-LNIM 881
Query: 758 VVGNPRPTITWCKNNKP---------VKALPTKSDGDTHSITI------LKPKKVKDEGV 802
+ ++ W K ++A SD TH T+ ++ +E
Sbjct: 882 DITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYT 941
Query: 803 YTLKAENSEGIA--ETSAVITVEEPTEENAEPPLFINR-FQEITVKEKG-TIKLVARVTR 858
+ + A NS G + S + V+E T P L + +Q++ + + G IK+ V
Sbjct: 942 FQVMAVNSAGRSAPRESRPVIVKEQT---MLPELDLRGIYQKLVIAKAGDNIKVEIPVLG 998
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVIT-NVDSEIDSGDYKCVASNSAGKSSH 917
P P++TW + ++I+ ++ + NF+ ++ N DSG Y A N G+
Sbjct: 999 RPKPTVTWKKGDQILKQTQRV--NFETTATSTILNINECVRSDSGPYPLTARNIVGEV-- 1054
Query: 918 GARVTIDVEKV 928
G +TI V +
Sbjct: 1055 GDVITIQVHDI 1065
Score = 37.5 bits (83), Expect = 0.52
Identities = 29/125 (23%), Positives = 54/125 (43%), Gaps = 5/125 (4%)
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFI---NRFQEITVKEKGTIKLVA-RVTR 858
+ ++A+N+ G + T ++ E P + +T+K TI L A +
Sbjct: 253 FRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILG 312
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P+P +W + + I PS+ ITQ ++ + D+G+Y A+N G
Sbjct: 313 KPLPKSSWSKAGKDIRPSD-ITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEH 371
Query: 919 ARVTI 923
+VT+
Sbjct: 372 VKVTV 376
Score = 37.5 bits (83), Expect = 0.52
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 3/68 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV-IREVFPEDAGTFT 582
G ++ E V G P+P +TW + I+K +Q ++ ++ +T++ I E D+G +
Sbjct: 987 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQ--RVNFETTATSTILNINECVRSDSGPYP 1044
Query: 583 CVAKNAAG 590
A+N G
Sbjct: 1045 LTARNIVG 1052
Score = 35.1 bits (77), Expect = 2.8
Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 505 EQSMAPIF---VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
E+ MAP F E R G +++ ++G P P++TW + +K + + +
Sbjct: 676 EREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIE---N 732
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAG 590
++ L+I E D G F +N AG
Sbjct: 733 TESFTLLIIPECNRYDTGKFVMTIENPAG 761
>DQ248309-1|ABB55264.1| 851|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.14 protein.
Length = 851
Score = 202 bits (493), Expect = 1e-50
Identities = 173/638 (27%), Positives = 282/638 (44%), Gaps = 38/638 (5%)
Query: 750 ESVILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ VIL ++ P + W K+ K P K K+DG + ILK D G YT
Sbjct: 14 DEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKKRML-ILKKALKSDIGQYTCD 71
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
G +TS + +E+ + P + V E T + ++ + + + W
Sbjct: 72 C----GTDKTSGKLDIEDREIKLVRP------LHSVEVMETETARFETEISEDDIHA-NW 120
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
E + + +G+ LV+ N + +G A+N KSS RV V
Sbjct: 121 KLKGEALLQTPDCEIKEEGKIHSLVLHNCRLD-QTGGVDFQAANV--KSSAHLRVKPRV- 176
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
+ ++ L K G+T +C+ S+ + +WY K++ D EG+
Sbjct: 177 -IGLLRPL-KDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLT 234
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G ++ KD +T L VKE EF + L+D V+E A+LE E++ E A
Sbjct: 235 LRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENA 294
Query: 1046 DVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
V W ++G EI+K KK Y+ G +RKL I + + D Y+C +D + + VV
Sbjct: 295 KVKWFKNGTEILKSKK--YEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVP 352
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
E + L + +V + A FE EL++ +A V+WFKDG+EI+ + G + L
Sbjct: 353 PHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILV 412
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
I C LDD EYSCEV ++ + +LTV E FT L I V L E+
Sbjct: 413 INKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLAN-IEVSETDTIKLVCEVSKPG 471
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+V WYK I +T ++ ++++ +KR L+I+ +D Y C L S T KV+V
Sbjct: 472 AEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRL--PSSRTDGKVKVH 529
Query: 1285 EFPPKIVDYEREYRIKRG--SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
E + + + I G ++ + ++FP +W + K ++ D K
Sbjct: 530 ELAAEFISKPQNLEILEGEKAEFVCSISKESFPV---QWKRDDKTLESGDKYDVIADGKK 586
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
L +K D G Y + + G A ++T+++K
Sbjct: 587 RVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEK 620
Score = 192 bits (468), Expect = 1e-47
Identities = 188/710 (26%), Positives = 296/710 (41%), Gaps = 47/710 (6%)
Query: 660 IPEPDIA--WLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
I E DI W KGE ++ + + E +H L + N + Q G A N +
Sbjct: 111 ISEDDIHANWKLKGEALLQTPDCEIKEEGKIHS----LVLHNCRLDQTGGVDFQAANVKS 166
Query: 718 EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNK--PV 775
A L + ++ G ++ PLK + V GE+ ++ P + K K P
Sbjct: 167 SAHLRVKPRV-IG------LLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPS 219
Query: 776 KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLF 835
+ +S+G H++T L+ K++D G L A++ + T A + V+EP E +P
Sbjct: 220 DKVVPRSEGKVHTLT-LRDVKLEDAGEVQLTAKDFK----THANLFVKEPPVEFTKP--- 271
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV 895
++ TV+E T L V+R + W++N I S+ DG +LVI +
Sbjct: 272 ---LEDQTVEEGATAVLECEVSRENA-KVKWFKNGTEILKSKKYEIVADGRVRKLVIHDC 327
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH- 954
E D Y C A + K+S + + V F++ L + E + EC+ S
Sbjct: 328 TPE-DIKTYTCDAKDF--KTS--CNLNVVPPHVEFLRPLT-DLQVREKEMARFECELSRE 381
Query: 955 TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKE 1014
KW+ + EI +II +G D C V+ TS ML V E
Sbjct: 382 NAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLE 441
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWER-DGEIIKPKKNKYDFEKRGHIRK 1073
F + L + EV E D L E++ A+V+W + D EII+ +Y+ G R
Sbjct: 442 EEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIET--GRYEILTEGRKRI 499
Query: 1074 LYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKG 1133
L I+N + D G Y+C L +V V EL E I++ QN ++ +G KA F ++K
Sbjct: 500 LVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKE 559
Query: 1134 DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
V+W +D ++ + + DGKK+ L + D L D G Y VG ++ A LTV E
Sbjct: 560 SFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE 619
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
+ + L + V + E+ E W++ + I D+ K+ ++ TL
Sbjct: 620 -KLRIVVPLKD-TRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTL 677
Query: 1254 IIRKCTEDDQCEYTCVLL-----DAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLL 1308
IR DDQ Y L + KS L VE E +IV+ ++ VT
Sbjct: 678 RIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE--EEDLRIVEPLKDIETMEKKSVTFW 735
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
+W N + + +D LTIK D G Y
Sbjct: 736 CKVNRL-NVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEY 784
Score = 183 bits (446), Expect = 5e-45
Identities = 141/560 (25%), Positives = 244/560 (43%), Gaps = 17/560 (3%)
Query: 835 FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITN 894
F + Q+ T EK + L +++ P + W+++ + I PS+ DG+ L++
Sbjct: 1 FTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKKRMLILKK 59
Query: 895 VDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH 954
+ D G Y C G ++ I+ ++ V+ L S E E +T E + S
Sbjct: 60 A-LKSDIGQYTC----DCGTDKTSGKLDIEDREIKLVRPLH-SVEVMETETARFETEISE 113
Query: 955 T-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVK 1013
+ W + + EI +EG+ G + + ++S L VK
Sbjct: 114 DDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVK 173
Query: 1014 ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
+ +R L+D V + A + E++ E V W G+ ++P +K G +
Sbjct: 174 PRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPS-DKVVPRSEGKVHT 232
Query: 1074 LYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKG 1133
L +R+ + D GE +D A + V E P E L++Q V +G A E E+++
Sbjct: 233 LTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRE 292
Query: 1134 DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
+A V+WFK+G+EI S ++ DG+ +KL I+DC +D Y+C+ + K + L V
Sbjct: 293 NAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVP 352
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
P + F L + + V A E+ E V W+K + I+ +K+ +IS R L
Sbjct: 353 PHVEFLRPLTD-LQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRIL 411
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKV--EVVEFPPKIVDYEREYRIKRGSDVTLLVDY 1311
+I KC DD+ EY+C + A+++ L V E F + + E +D LV
Sbjct: 412 VINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVSE-----TDTIKLVCE 466
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
+ P W + I + + + + L I+ DAG Y RL ++ V
Sbjct: 467 VSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKV 526
Query: 1372 EMNVTILDKPSPPGKPNILE 1391
+++ + S P ILE
Sbjct: 527 KVHELAAEFISKPQNLEILE 546
Score = 160 bits (388), Expect = 6e-38
Identities = 155/622 (24%), Positives = 257/622 (41%), Gaps = 45/622 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P F+K + Q V+EG+ +LEC V+ + W G EI+ + + + +
Sbjct: 265 PVEFTKPLEDQTVEEGATAVLECE-VSRENAKVKWFKNGTEILKSKKYEIVADGRVRK-- 321
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGE 750
L I + TYT A + + +L +V PP V + PL + VR+ E
Sbjct: 322 --LVIHDCTPEDIKTYTCDAKDFKTSCNLNVV---------PPHVEFLRPLTDLQVREKE 370
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKK--VKDEGVYTLKAE 808
++ + W K+ +K ++ IL K + DE Y+ +
Sbjct: 371 MARFECEL-SRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR 429
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
A TS ++TV E E +F I V E TIKLV V++ P + WY+
Sbjct: 430 T----ARTSGMLTVLE------EEAVFTKNLANIEVSETDTIKLVCEVSK-PGAEVIWYK 478
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
+E I + +G LVI N E D+G+Y C +S +V +
Sbjct: 479 GDEEIIETGRYEILTEGRKRILVIQNAHLE-DAGNYNCRLPSSRTDG----KVKVHELAA 533
Query: 929 TFVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
F+ Q + E EG+ C S + +W + K + D ++I +G+
Sbjct: 534 EFISKPQ-NLEILEGEKAEFVCSISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVK 592
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADV 1047
D+G +V + L V E + + L+D VKE+ + E+N+E A
Sbjct: 593 DATLQDMGTYVVMVGAARAAAHLTVIEKL-RIVVPLKDTRVKEQQEVVFNCEVNTEGAKA 651
Query: 1048 VWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL---RDESC--TAEVTV 1102
W R+ E I +KY ++ + L IR+ + D+ Y+ L R E+ A + V
Sbjct: 652 KWFRNEEAIFDS-SKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIV 710
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
E I+ L++ + + TF ++ + + ++W K+G E+ F N + +D K
Sbjct: 711 EEEDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHM 770
Query: 1163 LKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
L I DC D GEY G K A L + E F L E V DA + ++
Sbjct: 771 LTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVEHL-EDQTVTEFDDAVFSCQLSR 829
Query: 1223 ETLDVTWYKKKSVIEDTEKFTL 1244
E +V WY+ I++ +K +
Sbjct: 830 EKANVKWYRNGREIKEGKKIQI 851
Score = 155 bits (376), Expect = 2e-36
Identities = 158/700 (22%), Positives = 283/700 (40%), Gaps = 52/700 (7%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G +C L + + + W KG+++ P + + E +H L + +VK
Sbjct: 188 VTAGETATFDCEL-SYEDIPVEWYLKGKKLEPSDKVVPRSEGKVH----TLTLRDVKLED 242
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPP-QVIEPLKSMIVRQGESVILSAQVVGNPR 763
G + A + + A+L + KEPP + +PL+ V +G + +L +V
Sbjct: 243 AGEVQLTAKDFKTHANLFV--------KEPPVEFTKPLEDQTVEEGATAVLECEV-SREN 293
Query: 764 PTITWCKNNKPV---KALPTKSDGDTHSITI--LKPKKVKDEGVYTLKAENSEGIAETSA 818
+ W KN + K +DG + I P+ +K YT A++ + TS
Sbjct: 294 AKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIK---TYTCDAKDFK----TSC 346
Query: 819 VITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET 878
+ V P E F+ ++ V+EK + ++R + W+++ I +
Sbjct: 347 NLNVVPPHVE------FLRPLTDLQVREKEMARFECELSRENA-KVKWFKDGAEIKKGKK 399
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
G + +++ N D +Y C + ++S +T+ E+ F K+L +
Sbjct: 400 YDIISKGA-VRILVINKCLLDDEAEYSCEVRTA--RTS--GMLTVLEEEAVFTKNLA-NI 453
Query: 939 ETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
E E T+ L C+ S WY +EI EI+ EGR D G
Sbjct: 454 EVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNY 513
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
C + T + V E EFI K Q+ E+ E + A I+ E+ V W+RD + ++
Sbjct: 514 NCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQWKRDDKTLE 573
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
+KYD G R L +++ ++ D G Y ++ A +TV+E I+ L++ +
Sbjct: 574 -SGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE-KLRIVVPLKDTR 631
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + + F E+ A +WF++ I S+ + L+I D LDD Y+
Sbjct: 632 VKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYN 691
Query: 1178 CEVGNS-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
+ N K A L VEE + L + + + + ++ + + W K
Sbjct: 692 VSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWC-KVNRLNVTLKWTKN 750
Query: 1233 KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
+ + + D K L I+ C D+ EY KS +L ++E P + V+
Sbjct: 751 GEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELL--IIEAPTEFVE 808
Query: 1293 YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
+ + + D + N +W N + IK+ K
Sbjct: 809 HLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKEGK 847
Score = 116 bits (279), Expect = 9e-25
Identities = 144/611 (23%), Positives = 254/611 (41%), Gaps = 66/611 (10%)
Query: 1112 RLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLD 1171
+LQ+ + ++ + E++K DA V+WFKDG EI+ S + + DGKK+ L +
Sbjct: 4 KLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKS 63
Query: 1172 DAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYK 1231
D G+Y+C+ G K + L +E+ I L ++ T + T EI ++ + W
Sbjct: 64 DIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFET-EISEDDIHANWKL 122
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
K + T + + K +L++ C D + KS+ L+V+ P+++
Sbjct: 123 KGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVK-----PRVI 177
Query: 1292 DYER---EYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
R + + G T + Y+ P EW + K ++ P + K +LT
Sbjct: 178 GLLRPLKDVTVTAGETATFDCELSYEDIPV---EWYLKGKKLEPSDKVVPRSEGKVHTLT 234
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPEN 1406
++ V+ DAG +L ++ HA N+ + + P KP LE D+
Sbjct: 235 LRDVKLEDAGEVQLTAKDFKTHA----NLFVKEPPVEFTKP--LE----------DQTVE 278
Query: 1407 TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV---DISD 1463
G + ++ V +E +W KN T+ S + + + R R +++ DI
Sbjct: 279 EGATAVLECEVS-RENAKVKWF--KNGTEILKS-KKYEIVADGRVRKLVIHDCTPEDIKT 334
Query: 1464 ASETTEYYKVIKETKIQSPTVE--KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKK 1521
+ + +K + P VE +PL ++ E C KV W++DG +
Sbjct: 335 YTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSR-ENAKVKWFKDGAE 393
Query: 1522 LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV-GIQQKPVITISNED- 1579
+K K Y+ KC+ +D E E SC V + ++T+ E+
Sbjct: 394 IKKGK-KYD-----IISKGAVRILVINKCL-LDD--EAEYSCEVRTARTSGMLTVLEEEA 444
Query: 1580 IKQKHKVGDEWLVTAVIEGI-----PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKE 1634
+ K+ E T I+ + P EVIWYK ++ Y I T+ + ++ I+
Sbjct: 445 VFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQN 504
Query: 1635 LKRSHSSKYT--IEASNTAGTSSV-EVTLKVYDKPS-----KPEGPVIMREISRESVTIE 1686
+ Y + +S T G V E+ + KP + E + IS+ES ++
Sbjct: 505 AHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFPVQ 564
Query: 1687 WKPPLDDGGLE 1697
WK DD LE
Sbjct: 565 WK--RDDKTLE 573
Score = 44.4 bits (100), Expect = 0.005
Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F + L + +G+T EC+V ++ WF+ I S+ +++ D V LVI
Sbjct: 268 FTKPLEDQTVEEGATAVLECEVSR-ENAKVKWFKNGTEILKSKKYEIVADG-RVRKLVIH 325
Query: 572 EVFPEDAGTFTCVAKN 587
+ PED T+TC AK+
Sbjct: 326 DCTPEDIKTYTCDAKD 341
Score = 42.7 bits (96), Expect = 0.014
Identities = 96/501 (19%), Positives = 179/501 (35%), Gaps = 41/501 (8%)
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
+W + K IK K+ D K L +KK +D G Y +CG + I D
Sbjct: 30 KWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTC----DCGTDKTSGKLDIED 85
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS 1439
+ +P + ++ E E + + + ++ + + T +K K +
Sbjct: 86 REIKLVRP-LHSVEVMETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSL 144
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDI 1499
+ + R VD A+ + + +K I + +PLK++T E
Sbjct: 145 VL-------HNCRLDQTGGVDFQAANVKSSAHLRVKPRVIG---LLRPLKDVTVTAGETA 194
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
C P V WY GKKL+ + + + D GEV
Sbjct: 195 TFDCELSYEDIP-VEWYLKGKKLEPSDKVVPR-------SEGKVHTLTLRDVKLEDAGEV 246
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWL---VTAVIEGIPPPE---VIWYKNGNKL 1613
+ + + + + ++ + D+ + TAV+E E V W+KNG ++
Sbjct: 247 QLTAK-DFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEI 305
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
K+Y I + + I + YT +A + + ++ V + + + +P +
Sbjct: 306 LKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNV-VPPHVEFLRPLTDL 364
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNE 1733
+RE +E E + ++ ++ K E + I V V C+ L++
Sbjct: 365 QVRE--KEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCL--LDD 420
Query: 1734 NCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP-SXXXXXXXXXXIDNESVYITWFPSE 1792
EY V G LE E + K ++ S + + W+
Sbjct: 421 EAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWY--- 477
Query: 1793 KNGGSPIIDY-KVEIKQEGKK 1812
G II+ + EI EG+K
Sbjct: 478 -KGDEEIIETGRYEILTEGRK 497
Score = 33.9 bits (74), Expect = 6.4
Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 2/64 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T F+C++ Y + W+ + ++PS D + + V TL +R+V EDAG
Sbjct: 191 GETATFDCELS-YEDIPVEWYLKGKKLEPS-DKVVPRSEGKVHTLTLRDVKLEDAGEVQL 248
Query: 584 VAKN 587
AK+
Sbjct: 249 TAKD 252
>BC115397-1|AAI15398.1| 867|Homo sapiens IGSF22 protein protein.
Length = 867
Score = 196 bits (479), Expect = 5e-49
Identities = 167/757 (22%), Positives = 322/757 (42%), Gaps = 49/757 (6%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P+ +E + + +G+ + A+V GNP+P I+W K +P K +I K
Sbjct: 67 PEFVEKPQPVTAPEGDKAVFRARVQGNPKPHISW----KRESGIPIKESAKIFYDSINKE 122
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
+K E + + ++N + IA + + L + QE K K +
Sbjct: 123 HVLKLEPLTSDDSDNYKCIASNDHADAIYTVS-------LLVTEGQE-----KMDFKKML 170
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+ P P + ++ + E + I + D E +Y +
Sbjct: 171 KKRAPPAPK---KKQKKVANEKEML-------EILSKVPKKDFEKVCMEYGFTDFRGLLR 220
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC---QTSHTVSTKWYHNKKEIS--- 968
+ ++VE + +K L+ E++ TV+ +C V W + +
Sbjct: 221 KLKEMKKKVEVEAIRILKPLEDK-ESKVDTTVVFDCIMELKDPNVKMIWIKGTEPLRIQY 279
Query: 969 GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEV 1028
+ ++ Q G D G+ V D+ S L V + +F+ +++ +V
Sbjct: 280 SLGKYDVKQMGTKYMLVISNVNMNDAGIYSLSVGDKRMSAELTVLDEPLKFLGEMKPVKV 339
Query: 1029 KEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDF--EKRGHIRKLYIRNTSVHDEGE 1086
E+ A+ E+ ++ + + VW+ +G+ +K + +KY+ + G L I++ + D GE
Sbjct: 340 TERQTAVFEIRLSKKEPNFVWKFNGKELK-RDDKYEITVSEDGLTHTLKIKDARLSDSGE 398
Query: 1087 YSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEI 1146
+S + A++T+ +P + ++ L+N +V + ++A E ELT D +RW KDG +
Sbjct: 399 FSAEAGNLVQKAQLTIDRIPIKFVSNLKNVRVKERSRACLECELTSKDVTLRWKKDGQLL 458
Query: 1147 QFSNHIQLTIDGKKQKLKIYDCDLDDAGEY---SCEVGNSK---CTAILTVEEPSINFTL 1200
+ +GK+ +L I D L D GEY + + G+ TAI+TVEE
Sbjct: 459 MHGTKYSMNHEGKQAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAIVTVEERLATVKS 518
Query: 1201 RLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
+ + + + A L V + DE ++ W K I D ++ LI
Sbjct: 519 GMSD-VHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGVQIVKQGAVHKLIFPSMGP 577
Query: 1261 DDQCEYTCVLLDAKSTTKLKV-EVVEFPPKIVDYEREYRI--KRGSDVTLLVDYQAFPQP 1317
+ + +YT +S + + + P +++ + I K G + V ++ P P
Sbjct: 578 EHEGKYTFRAKGTESEASVFIADPPTIDPSVLEALAAHAITVKVGHTAHIKVPFRGKPLP 637
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
W + + + + A LTI D+G+ L+L+N+ G A +++++
Sbjct: 638 KVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSGLILLKLKNDHGSATATLHLSV 697
Query: 1378 LDKPSPP-GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNI--T 1434
LD+P PP G+ LE+ S +++ W P++ G + ++VE + + WI + +
Sbjct: 698 LDRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVERRAVGKKSWIKIGEVDGK 757
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
T S ++ +Y+FR AVN +SD ET E +
Sbjct: 758 VTNFSTNKVEEGKAYQFRILAVNSEGVSDPLETEEVF 794
Score = 140 bits (339), Expect = 5e-32
Identities = 129/605 (21%), Positives = 249/605 (41%), Gaps = 29/605 (4%)
Query: 1218 VEIPDETLDVTWYKKKSVIE---DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
+E+ D + + W K + K+ + K L+I +D Y+ + D +
Sbjct: 257 MELKDPNVKMIWIKGTEPLRIQYSLGKYDVKQMGTKYMLVISNVNMNDAGIYSLSVGDKR 316
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
+ +L V ++ P K + + ++ + +PN W N K +K+
Sbjct: 317 MSAELTV--LDEPLKFLGEMKPVKVTERQTAVFEIRLSK-KEPNFVWKFNGKELKRDDKY 373
Query: 1335 KPSI--DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ ++ D + +L IK +D+G + N A + ++ + S + E
Sbjct: 374 EITVSEDGLTHTLKIKDARLSDSGEFSAEAGNLVQKAQLTIDRIPIKFVSNLKNVRVKER 433
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK-TQTSIQNLKTNSSYRF 1451
+ + E E T + + + Q + S+ + K + I++ + + +
Sbjct: 434 SRACL-----ECELTSKDVTLRWKKDGQLLMHGTKYSMNHEGKQAELIIEDAQLSDGGEY 488
Query: 1452 RAYAVNEVDISDASETTEYYKV-IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
A+ + D TEYY I + + TV+ + ++ EL C+ +
Sbjct: 489 TVVAMQDGD------PTEYYSTAIVTVEERLATVKSGMSDVHAATGSPAEL-CVVLNDEK 541
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKC-IAFNDHGEVETSCVVGIQQ 1569
+ W +DGK++ + ++ F G E+ V I
Sbjct: 542 VEGVWLKDGKEITDLPGVQIVKQGAVHKLIFPSMGPEHEGKYTFRAKG-TESEASVFIAD 600
Query: 1570 KPVITISNEDIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE 1625
P I S + H KVG + G P P+V WYK+G ++ ++ ++ E
Sbjct: 601 PPTIDPSVLEALAAHAITVKVGHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGE 660
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+++ I R S ++ N G+++ + L V D+P P+G V E+S V +
Sbjct: 661 DQALLTISNCVREDSGLILLKLKNDHGSATATLHLSVLDRPKPPQGRVEFLELSGSCVHM 720
Query: 1686 EWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQN 1745
+WK P D+GG +T++ +E+ WIK+ +VD V + K+ E Y FR++A N
Sbjct: 721 KWKAPKDNGGRPVTQFIVERRAVGKKSWIKIGEVDGKVTNFSTNKVEEGKAYQFRILAVN 780
Query: 1746 PVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE 1805
G S+ LE+E + ++ P + E+V ITW ++GG+P++ Y VE
Sbjct: 781 SEGVSDPLETEEVFAGNPIE-PPGFASQPQVTDVTKEAVTITWNAPTQDGGAPVLGYIVE 839
Query: 1806 IKQEG 1810
+++G
Sbjct: 840 RRKKG 844
Score = 128 bits (308), Expect = 3e-28
Identities = 132/570 (23%), Positives = 232/570 (40%), Gaps = 32/570 (5%)
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGK 944
G LVI+NV+ D+G Y S S G A +T+ E + F+ + K + E +
Sbjct: 290 GTKYMLVISNVNMN-DAGIY----SLSVGDKRMSAELTVLDEPLKFLGEM-KPVKVTERQ 343
Query: 945 TVILECQTSHTVST-KWYHNKKEISGMDHREII--QEGRXXXXXXXXXXXXDVGVIKCIV 1001
T + E + S W N KE+ D EI ++G D G
Sbjct: 344 TAVFEIRLSKKEPNFVWKFNGKELKRDDKYEITVSEDGLTHTLKIKDARLSDSGEFSAEA 403
Query: 1002 KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKN 1061
+ L + +F+ L++ VKE+ A LE E+ S+ + W++DG+++
Sbjct: 404 GNLVQKAQLTIDRIPIKFVSNLKNVRVKERSRACLECELTSKDVTLRWKKDGQLLM-HGT 462
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES------CTAEVTVVELPPEIITRLQN 1115
KY G +L I + + D GEY+ + + TA VTV E + + + +
Sbjct: 463 KYSMNHEGKQAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAIVTVEERLATVKSGMSD 522
Query: 1116 QKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGE 1175
G+ A + L W KDG EI +Q+ G KL + G+
Sbjct: 523 VHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGVQIVKQGAVHKLIFPSMGPEHEGK 582
Query: 1176 YSCEV-GNSKCTAILTVEEPSINFTLR---LPEFILVPANTDAYLTVEIPDETLD-VTWY 1230
Y+ G ++ + P+I+ ++ I V A++ V + L VTWY
Sbjct: 583 YTFRAKGTESEASVFIADPPTIDPSVLEALAAHAITVKVGHTAHIKVPFRGKPLPKVTWY 642
Query: 1231 KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPP 1288
K + + E+ ++ + L I C +D L + +T L + V++ P
Sbjct: 643 KDGMEVTEEERVSMERGEDQALLTISNCVREDSGLILLKLKNDHGSATATLHLSVLD-RP 701
Query: 1289 KIVDYEREYRIKRGSDVTLL--VDYQAFPQPNDEWIVNSKIIKKCKHTK-PSIDSKSASL 1345
K E+ GS V + +P ++IV + + K K +D K +
Sbjct: 702 KPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVERRAVGKKSWIKIGEVDGKVTNF 761
Query: 1346 TIKKVENTDAGIYKLRLENNCGHAD-VEMNVTILDKP-SPPG---KPNILEIDSSSINIC 1400
+ KVE A +++ N+ G +D +E P PPG +P + ++ ++ I
Sbjct: 762 STNKVEEGKAYQFRILAVNSEGVSDPLETEEVFAGNPIEPPGFASQPQVTDVTKEAVTIT 821
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWISV 1430
W+ P G + ++ Y+VE ++ + W+ V
Sbjct: 822 WNAPTQDGGAPVLGYIVERRKKGSNLWVPV 851
Score = 95.9 bits (228), Expect = 1e-18
Identities = 55/157 (35%), Positives = 76/157 (48%), Gaps = 2/157 (1%)
Query: 1863 LTPPSQPRNFV-VSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
L P P+ V E + V +KW P+ NGG P+T +I+E + V KSW KI V G
Sbjct: 698 LDRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVERRAVGKKSWIKIGEVDGK 757
Query: 1922 VHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSN 1981
V ++E FRI A N+ GVS P E++ V P + P ++ V
Sbjct: 758 VTNFSTNKVEEGKAYQFRILAVNSEGVSDPLETEEVFAGNPIEPPGFASQP-QVTDVTKE 816
Query: 1982 IVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
V +W P DGGAP+LGY + R +W+ V K
Sbjct: 817 AVTITWNAPTQDGGAPVLGYIVERRKKGSNLWVPVNK 853
Score = 87.8 bits (208), Expect = 4e-16
Identities = 170/833 (20%), Positives = 292/833 (35%), Gaps = 72/833 (8%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKD-GSEIQFSNHIQLTIDGKKQKLK 1164
PE + + Q +G+KA F + + W ++ G I+ S I K+ LK
Sbjct: 67 PEFVEKPQPVTAPEGDKAVFRARVQGNPKPHISWKRESGIPIKESAKIFYDSINKEHVLK 126
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ DD+ Y C N AI TV ++ +
Sbjct: 127 LEPLTSDDSDNYKCIASNDHADAIYTVS------------LLVTEGQEKMDFKKMLKKRA 174
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK-LKVEV 1283
K+K V + E ++S V K+ + C E ++ +L K K ++VE
Sbjct: 175 PPAPKKKQKKVANEKEMLEILSKVPKKDFE-KVCMEYGFTDFRGLLRKLKEMKKKVEVEA 233
Query: 1284 VEFPPKIVDYEREYRIKRGSDVTLLVD-YQAFPQPNDE--WIVNSKIIKKCKHTKPSIDS 1340
+ + D E + D T++ D PN + WI ++ ++ +++ D
Sbjct: 234 IRILKPLEDKESKV------DTTVVFDCIMELKDPNVKMIWIKGTEPLR-IQYSLGKYDV 286
Query: 1341 KSAS----LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP---PGKP-NILEI 1392
K L I V DAGIY L + G + +T+LD+P KP + E
Sbjct: 287 KQMGTKYMLVISNVNMNDAGIYSLSV----GDKRMSAELTVLDEPLKFLGEMKPVKVTER 342
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRF 1451
++ I + E N + E + D E I+V T T I++ + + S F
Sbjct: 343 QTAVFEIRLSKKEP--NFVWKFNGKELKRDDKYE-ITVSEDGLTHTLKIKDARLSDSGEF 399
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQP 1511
A A N V + + K + LKN+ + L C
Sbjct: 400 SAEAGNLVQKAQLTIDRIPIKFVSN-----------LKNVRVKERSRACLECELTS-KDV 447
Query: 1512 KVTWYRDGKKLKTAKATYEN----RXXXXXXXXXXXXXXXYKCIAFNDHGEVE--TSCVV 1565
+ W +DG+ L N + Y +A D E ++ +V
Sbjct: 448 TLRWKKDGQLLMHGTKYSMNHEGKQAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAIV 507
Query: 1566 GIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE 1625
++++ + T+ + + H V+ E +W K+G ++ + I +
Sbjct: 508 TVEER-LATVKS-GMSDVHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGVQIVKQG 565
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ + H KYT A T +SV + PS E + T
Sbjct: 566 AVHKLIFPSMGPEHEGKYTFRAKGTESEASVFIADPPTIDPSVLEALAAHAITVKVGHTA 625
Query: 1686 EWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQN 1745
K P L + + E + + + D I + + +N
Sbjct: 626 HIKVPFRGKPLPKVTWYKDGMEVTEEERVSM-ERGEDQALLTISNCVREDSGLILLKLKN 684
Query: 1746 PVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE 1805
G + A + + LD P + V++ W + NGG P+ + VE
Sbjct: 685 DHGSATAT-----LHLSVLDRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVE 739
Query: 1806 IKQEGKK-WKXXXXXXXXXARIQ--KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKT 1862
+ GKK W K+ YQFRI A N G S P +++ + G
Sbjct: 740 RRAVGKKSWIKIGEVDGKVTNFSTNKVEEGKAYQFRILAVNSEGVSDPLETEE-VFAGNP 798
Query: 1863 LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+ PP V++ T +VT+ W P +GG+P+ YI+E + W +
Sbjct: 799 IEPPGFASQPQVTDVTKEAVTITWNAPTQDGGAPVLGYIVERRKKGSNLWVPV 851
Score = 69.7 bits (163), Expect = 1e-10
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 5/139 (3%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTS 1986
I N +D + + +N G + T SV L++ P PP +E + + V
Sbjct: 667 ISNCVREDSGLILLKLKNDHGSATATLHLSV-LDR----PKPPQGRVEFLELSGSCVHMK 721
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P+ +GG P+ + + R V K W+++G+VD F+ + E Y RI A N
Sbjct: 722 WKAPKDNGGRPVTQFIVERRAVGKKSWIKIGEVDGKVTNFSTNKVEEGKAYQFRILAVNS 781
Query: 2047 IGLSEPLESDEPFKVIPGE 2065
G+S+PLE++E F P E
Sbjct: 782 EGVSDPLETEEVFAGNPIE 800
Score = 57.6 bits (133), Expect = 5e-07
Identities = 70/291 (24%), Positives = 117/291 (40%), Gaps = 17/291 (5%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
++ IP F K V E S LEC L + + + W G+ ++ S+ E
Sbjct: 414 IDRIPIKFVSNLKNVRVKERSRACLECELTS-KDVTLRWKKDGQLLMHGTKYSMNHEGKQ 472
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ L I + + G YTVVA+ ++G+ + I T E+ V + +
Sbjct: 473 ----AELIIEDAQLSDGGEYTVVAM-QDGDPTEYYSTAIVTVEERLATVKSGMSDVHAAT 527
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTL 805
G L V+ + + W K+ K + LP G H + I + EG YT
Sbjct: 528 GSPAELCV-VLNDEKVEGVWLKDGKEITDLPGVQIVKQGAVHKL-IFPSMGPEHEGKYTF 585
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+A+ +E A +V + PT + + L ITVK T + P+P +T
Sbjct: 586 RAKGTESEA---SVFIADPPTIDPSV--LEALAAHAITVKVGHTAHIKVPFRGKPLPKVT 640
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
WY++ ++ E ++ + L I+N E DSG N G ++
Sbjct: 641 WYKDGMEVTEEERVSMERGEDQALLTISNCVRE-DSGLILLKLKNDHGSAT 690
Score = 56.4 bits (130), Expect = 1e-06
Identities = 32/93 (34%), Positives = 50/93 (53%), Gaps = 4/93 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAI-IKPSQDFQMYYDDDNVA-T 567
P FVEK +P P+G F +V+G P+P I+W R++ I IK S +++YD N
Sbjct: 67 PEFVEKPQPVTAPEGDKAVFRARVQGNPKPHISWKRESGIPIKESA--KIFYDSINKEHV 124
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
L + + +D+ + C+A N A T L+V
Sbjct: 125 LKLEPLTSDDSDNYKCIASNDHADAIYTVSLLV 157
Score = 55.2 bits (127), Expect = 2e-06
Identities = 48/158 (30%), Positives = 69/158 (43%), Gaps = 7/158 (4%)
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE 841
S TH T + K+ E V K S I E +++T P F+ + Q
Sbjct: 19 SSSTTHVQTFSQTTKIVGEEVVRRK---SSSIVEFFSLVTRSSNIPAGDSVPEFVEKPQP 75
Query: 842 ITVKEKGTIKLVARVTRNPVPSITWYRNNEI-ISPSETITQNFDGENIELVITNVDSEID 900
+T E ARV NP P I+W R + I I S I + + L + + S+ D
Sbjct: 76 VTAPEGDKAVFRARVQGNPKPHISWKRESGIPIKESAKIFYDSINKEHVLKLEPLTSD-D 134
Query: 901 SGDYKCVASNSAGKSSH--GARVTIDVEKVTFVKHLQK 936
S +YKC+ASN + + VT EK+ F K L+K
Sbjct: 135 SDNYKCIASNDHADAIYTVSLLVTEGQEKMDFKKMLKK 172
Score = 46.0 bits (104), Expect = 0.001
Identities = 45/196 (22%), Positives = 86/196 (43%), Gaps = 15/196 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P F + K V E + E RL + EP+ W F G+E+ D+ + + D +
Sbjct: 327 PLKFLGEMKPVKVTERQTAVFEIRL-SKKEPNFVWKFNGKELKRDDKYEITVSEDGLTH- 384
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
LKI + + G ++ A N +A L I ++ P + + LK++ V++
Sbjct: 385 -TLKIKDARLSDSGEFSAEAGNLVQKAQLTI-------DRIPIKFVSNLKNVRVKERSRA 436
Query: 753 ILSAQVVGNPRPTITWCKNNKPVK--ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
L ++ T+ W K+ + + + + + I++ ++ D G YT+ A
Sbjct: 437 CLECELTSKD-VTLRWKKDGQLLMHGTKYSMNHEGKQAELIIEDAQLSDGGEYTVVAMQD 495
Query: 811 EGIAE--TSAVITVEE 824
E ++A++TVEE
Sbjct: 496 GDPTEYYSTAIVTVEE 511
Score = 38.7 bits (86), Expect = 0.23
Identities = 23/86 (26%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T + G P P++TW++ + + M +D A L I ED+G
Sbjct: 622 GHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQ-ALLTISNCVREDSGLILL 680
Query: 584 VAKNAAGFASSTTEL-IVEAPLSDHG 608
KN G A++T L +++ P G
Sbjct: 681 KLKNDHGSATATLHLSVLDRPKPPQG 706
Score = 38.3 bits (85), Expect = 0.30
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 5/117 (4%)
Query: 1007 STMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEI-IKPK-KNKY 1063
S+ + +++PEF+ K Q E D A+ + + + W+R+ I IK K Y
Sbjct: 57 SSNIPAGDSVPEFVEKPQPVTAPEGDKAVFRARVQGNPKPHISWKRESGIPIKESAKIFY 116
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNK 1120
D + H+ KL + D Y CI ++ A TV L E ++ +K+ K
Sbjct: 117 DSINKEHVLKL--EPLTSDDSDNYKCIASNDHADAIYTVSLLVTEGQEKMDFKKMLK 171
Score = 36.3 bits (80), Expect = 1.2
Identities = 26/100 (26%), Positives = 43/100 (43%), Gaps = 3/100 (3%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F +KP+ EG + R+ P+P I+W K E +P + S I D
Sbjct: 67 PEFVEKPQPVTAPEGDKAVFRARVQGNPKPHISW--KRESGIPIKE-SAKIFYDSINKEH 123
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE 733
VLK+ + Y +A N +A + L + G+++
Sbjct: 124 VLKLEPLTSDDSDNYKCIASNDHADAIYTVSLLVTEGQEK 163
>AL670729-3|CAH71673.1| 6620|Homo sapiens obscurin, cytoskeletal
calmodulin and titin-interacting RhoGEF protein.
Length = 6620
Score = 192 bits (467), Expect = 2e-47
Identities = 166/673 (24%), Positives = 287/673 (42%), Gaps = 42/673 (6%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
++ +P F++ + + EG+ +L C L + + W KG E + D + + +
Sbjct: 3445 VKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP--VEWR-KGPENLRDGDRYILRQEGT 3501
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y V A+L I P + IE +K+ R+
Sbjct: 3502 R--CE-LQICGLAMADAGEYLCVCGQERTSATLTI-------RALPARFIEDVKNQEARE 3551
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTL 805
G + +L ++ N + W K ++ ++ + DG + I + + D G Y+
Sbjct: 3552 GATAVLQCEL--NSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQI-RGLAMADTGEYSC 3608
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
G TSA++TV A P F + E T V R + + +
Sbjct: 3609 VC----GQERTSAMLTVR------ALPIKFTEGLRNEEATEGATA--VLRCELSKMAPVE 3656
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W++ +E + + + DG EL I + +E D+G+Y C+ GK A +T+
Sbjct: 3657 WWKGHETLRDGDRHSLRQDGARCELQIRGLVAE-DAGEYLCMC----GKERTSAMLTVRA 3711
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
F++ L+ E EG T L C+ S +W + + D + Q+G
Sbjct: 3712 MPSKFIEGLRNE-EATEGDTATLWCELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQ 3770
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G C+ + TS L V+ FI +++ E +E A+L+ E+ S+ A
Sbjct: 3771 IRGLAVVDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCEL-SKAA 3829
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W + E ++ ++Y + G +L I SV D GEYSC+ E +A +TV
Sbjct: 3830 PVEWRKGSETLRGG-DRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAP 3888
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P LQ+ + +G+ AT + EL++ A V W K G ++Q + + + G +L +
Sbjct: 3889 QPVFREPLQSLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVL 3948
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D +D GEY+C G+ +A LTV + F LR + V A+L E+
Sbjct: 3949 QDLQREDTGEYTCTCGSQATSATLTVTAAPVRF-LRELQHQEVDEGGTAHLCCELSRAGA 4007
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-- 1283
V W K + K+ ++ D L++R ++D +YTC +S L V V
Sbjct: 4008 SVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRVPR 4067
Query: 1284 VEFPPKIVDYERE 1296
+F ++ E+E
Sbjct: 4068 PKFKTRLQSLEQE 4080
Score = 189 bits (461), Expect = 8e-47
Identities = 271/1259 (21%), Positives = 487/1259 (38%), Gaps = 118/1259 (9%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F L+ T + V EC++ P + W + ++ + + + + R
Sbjct: 2168 FSRPLQDVVTTEKEKVTLECELSR-PNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYR 2226
Query: 572 EVFPEDAGTFTCVAKNAAGFAS-----STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
F D G + C A +A AS T LI L++ E+
Sbjct: 2227 CEFA-DQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLR- 2284
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
++ +P T + + + E +LEC+ V+ + W +E+ P + +
Sbjct: 2285 --VKELPVTLVRPLRDKIAMEKHRGVLECQ-VSRASAQVRWFKGSQELQPGPKYELVSDG 2341
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+Y ++ I++V E TYT A + + A + E++ ++ L+ + V
Sbjct: 2342 ---LYRKLI-ISDVHAEDEDTYTCDAGDVKTSAQFFV-------EEQSITIVRGLQDVTV 2390
Query: 747 RQGESVILSAQV-VGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGV 802
+ + + + RP W ++A + + +G H + + + V
Sbjct: 2391 MEPAPAWFECETSIPSVRPP-KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPV 2449
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ + G + +SA + V + P + + T +E ++ L P
Sbjct: 2450 HF-----TVGKSRSSARLVVSDI------PVVLTRPLEPKTGRELQSVVLSCDFRPAP-K 2497
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
++ WY+++ +SPSE + +G+ EL I + D+G Y+C AG + VT
Sbjct: 2498 AVQWYKDDTPLSPSEKFKMSLEGQMAELRILRL-MPADAGVYRC----QAGSAHSSTEVT 2552
Query: 923 IDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRX 981
++ +VT LQ + TEEG C+ SH +W N + EI +GR
Sbjct: 2553 VEAREVTVTGPLQDAEATEEG-WASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRR 2611
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
D G+++ TS L V+ F++ L D +E+ L+ E++
Sbjct: 2612 HTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVS 2671
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
A VVW +DG + P +KYDF R L + + S D G Y+C + E A V
Sbjct: 2672 DPEAHVVWRKDGVQLGPS-DKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVR 2730
Query: 1102 VVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGK 1159
V +L I RL+ +V +G +FE L+ A W G + S+ Q T G+
Sbjct: 2731 VHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGR 2790
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVE 1219
K L + + DAGE V A L V E L + + P D L E
Sbjct: 2791 KYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGE-DVELRCE 2849
Query: 1220 IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
+ V W K + I ++K+ ++ + L+IR + D EYTC + +KST L
Sbjct: 2850 LSRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASL 2909
Query: 1280 KVEVVE--FPPKIVDYEREYRIKRGSDV-TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
VE F ++ + + E ++G+ V T ++ P W ++ +P
Sbjct: 2910 HVEEKANCFTEELTNLQVE---EKGTAVFTCKTEH---PAATVTWRKGLLELRASGKHQP 2963
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS 1396
S + + LTI +E D+ Y + G A + + + + +I+E D
Sbjct: 2964 SQEGLTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGR-----RVHIIE-DLED 3013
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
+++ G+S + + W K T + N + +
Sbjct: 3014 VDV------QEGSSATFRCRISPANYEPVHWFLDK--TPLHANELNEIDAQPGGYHVLTL 3065
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTV-EKP------LKNITTEPNEDIELTCIFGGVP 1509
++ + D+ T Y++ + + V EKP L + T ED+ L C
Sbjct: 3066 RQLALKDSG--TIYFEAGDQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCETSTCD 3123
Query: 1510 QPKVTWYRDGKKLKTA---KATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV 1565
P V W +DGK L+ + + ++E +R YKC A G +S +V
Sbjct: 3124 IP-VCWTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIV 3178
Query: 1566 GIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
+ +PV E +K + G + V+ + P V W N L +Y++ +
Sbjct: 3179 RVHARPVRF--QEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQE 3235
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ ++ L+ S +Y S + G + TL V P++ G + +E +
Sbjct: 3236 GAMLELVVRNLRPQDSGRY----SCSFGDQTTSATLTVTALPAQFIGKLRNKEAT----- 3286
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
+G + + K P W K ++ RD + YC+++ CE R +A
Sbjct: 3287 --------EGATATLRCELSKAAPVE--WRKGSETLRDGDRYCLRQDGAMCELQIRGLA 3335
Score = 180 bits (437), Expect = 7e-44
Identities = 169/669 (25%), Positives = 275/669 (41%), Gaps = 39/669 (5%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVIL 754
L I+ ++K TYT + A L + + +IE L+ + V++G S
Sbjct: 2972 LTISALEKADSDTYTCDIGQAQSRAQLLV-------QGRRVHIIEDLEDVDVQEGSSATF 3024
Query: 755 SAQVVGNPRPTITWCKNNKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENS 810
++ + W + P+ A G H +T L+ +KD G +A
Sbjct: 3025 RCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLT-LRQLALKDSGTIYFEA--- 3080
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G SA + V E +P +F + T+ E + LV + +P + W ++
Sbjct: 3081 -GDQRASAALRVTE------KPSVFSRELTDATITEGEDLTLVCETSTCDIP-VCWTKDG 3132
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
+ + S + +G +L+IT + DSG YKC A + S V + V F
Sbjct: 3133 KTLRGSARCQLSHEGHRAQLLITGATLQ-DSGRYKCEAGGACSSSI----VRVHARPVRF 3187
Query: 931 VKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ L K E EG L C S + KW + + D + QEG
Sbjct: 3188 QEAL-KDLEVLEGGAATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNL 3246
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVW 1049
D G C DQ TS L V +FI KL++ E E A L E+ S+ A V W
Sbjct: 3247 RPQDSGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCEL-SKAAPVEW 3305
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEI 1109
+ E ++ ++Y + G + +L IR ++ D EYSC+ +E +A +T+ +P
Sbjct: 3306 RKGSETLRDG-DRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHF 3364
Query: 1110 ITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
I RL++Q+ +G AT EL+K A V W K ++ + L DG +L+I
Sbjct: 3365 IGRLRHQESIEGATATLRCELSKA-APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423
Query: 1170 LDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+ DAGEYSC G + +A LTV+ FT L V T A L E+ + V W
Sbjct: 3424 VADAGEYSCVCGEERTSATLTVKALPAKFTEGLRNEEAVEGAT-AMLWCEL-SKVAPVEW 3481
Query: 1230 YKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPK 1289
K + D +++ L + + L I D EY CV +++ L + + P +
Sbjct: 3482 RKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRAL--PAR 3539
Query: 1290 IVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKK 1349
++ + + G+ L + + EW S+ ++ D L I+
Sbjct: 3540 FIEDVKNQEAREGATAVLQCELNSAAPV--EWRKGSETLRDGDRYSLRQDGTKCELQIRG 3597
Query: 1350 VENTDAGIY 1358
+ D G Y
Sbjct: 3598 LAMADTGEY 3606
Score = 170 bits (414), Expect = 4e-41
Identities = 196/889 (22%), Positives = 349/889 (39%), Gaps = 58/889 (6%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLV-AIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ +P F + K Q EG+ +L+C L A P + W E + + S+ +
Sbjct: 3797 VRALPARFIEDVKNQEAREGATAVLQCELSKAAP---VEWRKGSETLRGGDRYSLRQDGT 3853
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
C L+I + G Y+ V A+L + P EPL+S+
Sbjct: 3854 R---CE-LQIHGLSVADTGEYSCVCGQERTSATLTV-------RAPQPVFREPLQSLQAE 3902
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYT 804
+G + L ++ P T+ W K ++A + G T + +L+ + +D G YT
Sbjct: 3903 EGSTATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGCTAEL-VLQDLQREDTGEYT 3960
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P F+ Q V E GT L ++R S+
Sbjct: 3961 CTC----GSQATSATLTV------TAAPVRFLRELQHQEVDEGGTAHLCCELSRAGA-SV 4009
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + + + P DG EL++ V+ E D+GDY C G + A +++
Sbjct: 4010 EWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQE-DAGDYTC----DTGHTQSMASLSVR 4064
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHTVS---TKWYHNKKEISGMDHREIIQEGRX 981
V + F LQ S E E G L CQ S S +W E+ E+ +G
Sbjct: 4065 VPRPKFKTRLQ-SLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGAT 4123
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
D G C+ Q+T+ L V E +R L D EV + E++
Sbjct: 4124 RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVS 4183
Query: 1042 SETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
A V W G ++ + + G I L ++ + D G S L + + +A++
Sbjct: 4184 RAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQL 4243
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTID-G 1158
TV I+ LQ+ ++++G A+F+ L++ RW G +Q + +T++ G
Sbjct: 4244 TVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQG 4303
Query: 1159 KKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
L ++ L+DAG S VG C++ ++ + N +R E + +A
Sbjct: 4304 TLHLLTLHKVTLEDAGTVSFHVGT--CSSEAQLKVTAKNTVVRGLENVEALEGGEALFEC 4361
Query: 1219 EIPD-ETLDVTWYKKKSVIEDTEKFTLI--SDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
++ E TW + +E ++ + + L+++ D C T + D +
Sbjct: 4362 QLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGDMVT 4421
Query: 1276 TTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHT 1334
+ L V +I++ + ++ G+ +A P W +N ++
Sbjct: 4422 SAFLTVRGWRL--EILEPLKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSD 4479
Query: 1335 -KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEID 1393
+ D +L ++ + AG + C A +T+L P PP ++
Sbjct: 4480 WTVTADGSHHALLLRSAQPHHAG----EVTFACRDAVASARLTVLGLPDPPEDAEVVARS 4535
Query: 1394 SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFR 1452
S ++ + W P + G + Y VE +E T +W + + + + + L +YRFR
Sbjct: 4536 SHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFR 4595
Query: 1453 AYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIEL 1501
AV V + + ++ + K P P ++ ED+ L
Sbjct: 4596 VAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-ESRQVAAGEDVSL 4643
Score = 161 bits (392), Expect = 2e-38
Identities = 179/903 (19%), Positives = 342/903 (37%), Gaps = 56/903 (6%)
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
+DEG Y+ + G + V EP A+ L + Q E G ++
Sbjct: 863 QDEGTYSCRV----GEDSVDFRLRVSEPKVVFAKEQLARRKLQA----EAGASATLSCEV 914
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
+TWY++ + +S S + G LV+ + D+G+Y C AG
Sbjct: 915 AQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQA-GQADAGEYSC----EAGGQRL 969
Query: 918 GARVTIDVEKVTFVKH--LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHRE 974
+ + KV F K + E G + L C+ + WY + K++S
Sbjct: 970 SFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQTEVMWYKDGKKLSSSLKVH 1029
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKL---QDFEVKEK 1031
+ +G D G C + Q S L + E F ++ + + +
Sbjct: 1030 VEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAG 1089
Query: 1032 DVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
A+L E+ +V W +DG+ + +K E +G R+L + D GEYSC
Sbjct: 1090 ASAMLSCEVAQAQTEVTWYKDGKKLS-SSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148
Query: 1092 RDESCTAEVTVVELPPEIITRLQN----QKVNKGNKATFEIELTKGDALVRWFKDGSEIQ 1147
+ + + + E P + + Q+ + G A E+ + V W+KDG ++
Sbjct: 1149 GGQRVSFHLHITE-PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLS 1207
Query: 1148 FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR--LPEF 1205
S+ +++ + G ++L + DAGEYSCE G + + L + EP F +
Sbjct: 1208 SSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNE 1267
Query: 1206 ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
+ A A L+ E+ +VTWYK + + K + + R L++++ + D E
Sbjct: 1268 VRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327
Query: 1266 YTCVLLDAKSTTKLKV-EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
YTC + + L V E K R+ + + G+ TL + A Q W +
Sbjct: 1328 YTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEV-AQAQTEVTWYKD 1386
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL--ENNCGHADVEMNVTILDKPS 1382
K + + + L +++ D G Y + DV + K
Sbjct: 1387 GKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQ 1446
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
P + + +S+ C E T + + + +++ + + ++ + T+ +
Sbjct: 1447 PVHREVQAQAGASTTLSC----EVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQ 1502
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
+ E S+ ++ + E K + + + E L+
Sbjct: 1503 QAGQA-------VAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLS 1555
Query: 1503 CIFGGVPQPKVTWYRDGKKL-KTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
C Q +VTWY+DGKKL ++K E Y C A G+
Sbjct: 1556 CEVAQA-QTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKA----GD 1610
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDK 1617
S + + + V+ + ++ + T E EV WYK+G KL +
Sbjct: 1611 QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS 1670
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASN---TAGTSSVEVTLKVYDKPSKPEGPVI 1674
+ + T + +++ ++ + +Y+ EA + E+ ++ ++P + E P++
Sbjct: 1671 KVRVEAVGCTRRLVVQQAGQAEAGEYSCEAGGQQLSFRLQVAELEPQISERPCRRE-PLV 1729
Query: 1675 MRE 1677
++E
Sbjct: 1730 VKE 1732
Score = 161 bits (392), Expect = 2e-38
Identities = 200/904 (22%), Positives = 364/904 (40%), Gaps = 67/904 (7%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ +P F++ + + EG+ +L C L + + W +KG E + D + ++ D
Sbjct: 3621 VRALPIKFTEGLRNEEATEGATAVLRCELSKMAP--VEW-WKGHETLRDGDRH-SLRQD- 3675
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y + A L + P + IE L++ +
Sbjct: 3676 GARCE-LQIRGLVAEDAGEYLCMCGKERTSAMLTV-------RAMPSKFIEGLRNEEATE 3727
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKA 807
G++ L ++ + + W K ++ ++ DGD HS+ + +++ G+ + A
Sbjct: 3728 GDTATLWCEL--SKAAPVEWRKGHETLR------DGDRHSLRQDGSRCELQIRGLAVVDA 3779
Query: 808 ENSE---GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P FI + +E T L +++ +
Sbjct: 3780 GEYSCVCGQERTSATLTVR------ALPARFIEDVKNQEAREGATAVLQCELSK--AAPV 3831
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + +E + + + DG EL I + S D+G+Y CV G+ A +T+
Sbjct: 3832 EWRKGSETLRGGDRYSLRQDGTRCELQIHGL-SVADTGEYSCVC----GQERTSATLTVR 3886
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXX 983
+ F + LQ S + EEG T L+C+ S T + W ++ RE +G
Sbjct: 3887 APQPVFREPLQ-SLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAE 3945
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G C Q TS L V F+R+LQ EV E A L E++
Sbjct: 3946 LVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCCELSRA 4005
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
A V W + + P KY + G +L +R D G+Y+C A ++V
Sbjct: 4006 GASVEWRKGSLQLFPCA-KYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVR 4064
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
P+ TRLQ+ + G+ A +L+ + A+V+W K+G E+ ++ G +
Sbjct: 4065 VPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATR 4124
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP 1221
+L I+ + D GEY+C G K A L V EP + L + V A+ D + E+
Sbjct: 4125 ELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVD-AEVTADEDVEFSCEVS 4183
Query: 1222 DE-TLDVTWYKKKSVIEDTEKFTL-ISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
V W + ++ E + + D + TL ++ T +D + L + S+ +L
Sbjct: 4184 RAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQL 4243
Query: 1280 KVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
V E I++ ++ ++ G D + W + ++ + +++
Sbjct: 4244 TVRAPEV--TILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVE 4301
Query: 1340 SKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI--LEIDSSS 1396
+ LT+ KV DAG + C ++ ++ VT G N+ LE +
Sbjct: 4302 QGTLHLLTLHKVTLEDAGTVSFHV-GTCS-SEAQLKVT-AKNTVVRGLENVEALEGGEAL 4358
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
+PE ++ ++ + + E + +N + ++NL+ S R A
Sbjct: 4359 FECQLSQPEVAAHTWLLDDEPVHTS-ENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAG 4417
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG-GVPQPKVTW 1515
+ V T + ++ +++ + +PLKN TC VP + +W
Sbjct: 4418 DMV--------TSAFLTVRGWRLE---ILEPLKNAAVRAGAQACFTCTLSEAVPVGEASW 4466
Query: 1516 YRDG 1519
Y +G
Sbjct: 4467 YING 4470
Score = 161 bits (390), Expect = 3e-38
Identities = 157/735 (21%), Positives = 292/735 (39%), Gaps = 46/735 (6%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ G+ +L C VA + ++ W G+++ + + ++ L + K
Sbjct: 1087 EAGASAMLSCE-VAQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRR----LVLPQAGKADA 1141
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G Y+ A + L I KE Q + + G + +LS +V P+
Sbjct: 1142 GEYSCEAGGQRVSFHLHITEPKGVFAKE--QSVH--NEVQAEAGTTAMLSCEVA-QPQTE 1196
Query: 766 ITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+TW K+ K + + + + G T + + + K D G Y+ +A G S + +
Sbjct: 1197 VTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA-DAGEYSCEA----GGQRVSFQLHI 1251
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
EP A+ L N E+ + + L V + +TWY++ + +S S +
Sbjct: 1252 TEPKAVFAKEQLVHN---EVRTEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRIE 1307
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH--LQKSYET 940
G +LV+ + D+G+Y C AG + + K F K + +
Sbjct: 1308 AAGCMRQLVVQQA-GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA 1362
Query: 941 EEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
E G L C+ + WY + K++S + G D G C
Sbjct: 1363 EAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSC 1422
Query: 1000 IVKDQETSTMLVVKETIPEFIRKL---QDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
Q S L V E F ++ ++ + + L E+ +V+W +DG+ +
Sbjct: 1423 EAGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL 1482
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQ-- 1114
+K E G R+L ++ GEYSC + + + V E P + + Q
Sbjct: 1483 S-FSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAE-PKAVFAKEQPA 1540
Query: 1115 --NQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+ G AT E+ + V W+KDG ++ S+ +++ G ++L + + D
Sbjct: 1541 SREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQAD 1600
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEF--ILVPANTDAYLTVEIPDETLDVTWY 1230
AGEYSC+ G+ + + L V EP + F P + A A L+ E+ +VTWY
Sbjct: 1601 AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWY 1660
Query: 1231 KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
K + + K + + R L++++ + + EY+C +++V E P+I
Sbjct: 1661 KDGKKLSSSSKVRVEAVGCTRRLVVQQAGQAEAGEYSCEA--GGQQLSFRLQVAELEPQI 1718
Query: 1291 VD--YERE-YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
+ RE +K D+ L W+ + I++ K + + + +LT+
Sbjct: 1719 SERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTV 1778
Query: 1348 KKVENTDAGIYKLRL 1362
+ D+ IY R+
Sbjct: 1779 HGAQVLDSAIYSCRV 1793
Score = 152 bits (369), Expect = 1e-35
Identities = 142/641 (22%), Positives = 260/641 (40%), Gaps = 32/641 (4%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ G+ L C VA + ++ W G+++ + V L + + +
Sbjct: 1639 EAGASATLSCE-VAQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRR----LVVQQAGQAEA 1693
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G Y+ A ++ L + +++ E P EPL +V++ E +IL+A + T
Sbjct: 1694 GEYSCEAGGQQLSFRLQVA-ELEPQISERPCRREPL---VVKEHEDIILTATLATPSAAT 1749
Query: 766 ITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+TW K+ + K T S GDTH++T+ +V D +Y+ + +EG + V
Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTV-HGAQVLDSAIYSCRV-GAEG---QDFPVQV 1804
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
EE + F + + + GT+ L ++ + W N + +
Sbjct: 1805 EEVAAK------FCRLLEPVCGELGGTVTLACELSP-ACAEVVWRCGNTQLRVGKRFQMV 1857
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
+G L + + +E D+G+Y C + + A++T+ V +V + EE
Sbjct: 1858 AEGPVRSLTVLGLRAE-DAGEYVCESRDD----HTSAQLTVSVPRVVKFMSGLSTVVAEE 1912
Query: 943 GKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
G +C S + V+ W+ + + + I Q G D G I
Sbjct: 1913 GGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEA 1972
Query: 1002 KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKN 1061
+ +S L V+E F +KL+ V+E+ LEVE+ ++ W R+ + P KN
Sbjct: 1973 EGASSSAALRVREAPVLFKKKLEPQTVEERSSVTLEVELTRPWPELRWTRNATALAPGKN 2032
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKG 1121
+ G +L + N D G + C D+ A++TV ++ LQ + +
Sbjct: 2033 -VEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQ 2091
Query: 1122 NKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG 1181
AT E++L+ D W +DG Q L + G L + +D+G +
Sbjct: 2092 GTATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAE 2151
Query: 1182 NSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEK 1241
+A L V E ++F+ L + ++ L E+ +DV W K + +
Sbjct: 2152 GVHTSARLVVTELPVSFSRPLQD-VVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKT 2210
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
+ + R+L I +C DQ Y C DA+S+ +KV+
Sbjct: 2211 MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQ 2251
Score = 138 bits (334), Expect = 2e-31
Identities = 135/567 (23%), Positives = 235/567 (41%), Gaps = 35/567 (6%)
Query: 632 IPPTFSKKP---KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ P S++P + V E DI+L L + WL G EI + A + D
Sbjct: 1714 LEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDT 1773
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
H L + + Y+ V EG+ P+ +++ + +++EP+ +
Sbjct: 1774 H----TLTVHGAQVLDSAIYSC-RVGAEGQ-DFPV--QVEEVAAKFCRLLEPVCGEL--- 1822
Query: 749 GESVILSAQVVGNPRPTITWCKNN--KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G +V L+ ++ + C N + K ++G S+T+L + +D G Y +
Sbjct: 1823 GGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLG-LRAEDAGEYVCE 1881
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
+ + TSA +TV P F++ + +E G V+ + V ++ W
Sbjct: 1882 SRDDH----TSAQLTVSVPRVVK-----FMSGLSTVVAEEGGEATFQCVVSPSDV-AVVW 1931
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+R+ ++ PSE + G + L I+++ E D+G + + G SS A + +
Sbjct: 1932 FRDGALLQPSEKFAISQSGASHSLTISDLVLE-DAGQ---ITVEAEGASSSAA-LRVREA 1986
Query: 927 KVTFVKHLQKSYETEEGKTVILECQ-TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
V F K L+ EE +V LE + T +W N ++ + EI EG
Sbjct: 1987 PVLFKKKLEPQ-TVEERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLV 2045
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G C D +T L V+ +R LQ E +E+ A +EV+++
Sbjct: 2046 LHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADV 2105
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
D W RDG + + RG + L + D G +A + V EL
Sbjct: 2106 DGSWTRDGLRFQQGPTCH-LAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTEL 2164
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P LQ+ + K T E EL++ + VRW KDG E++ + + G + L I
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTI 2224
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVE 1192
Y C+ D G Y C+ +++ +A + V+
Sbjct: 2225 YRCEFADQGVYVCDAHDAQSSASVKVQ 2251
Score = 134 bits (325), Expect = 2e-30
Identities = 164/758 (21%), Positives = 285/758 (37%), Gaps = 49/758 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P F K +E + L+C V+ PE + W G ++ P + +
Sbjct: 2646 PVVFLKALDDLSAEERGTLALQCE-VSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRG-- 2702
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L + +V G YT + E A + V + G + + LK+M V +GES
Sbjct: 2703 --LVVHDVSPEDAGLYTCHVGSEETRARVR-VHDLHVG------ITKRLKTMEVLEGESC 2753
Query: 753 ----ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
+LS + +P K G + I +++ D G
Sbjct: 2754 SFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKY-ILVVREAAPSDAGEVVFSVR 2812
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
G+ +++I E P I ++ V ++L ++R P + W +
Sbjct: 2813 ---GLTSKASLIVRERPAA-------IIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLK 2861
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
+ + I S+ +G LVI + D+G+Y C A KS+ A + ++ +
Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLK-DAGEYTCEVE--ASKST--ASLHVEEKAN 2916
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXX 987
F + L + + EE T + C+T H +T W E+ + QEG
Sbjct: 2917 CFTEELT-NLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADV 1047
D C + ++ L+V+ I L+D +V+E A I+ +
Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEP 3035
Query: 1048 V-WERDGEIIKPKK-NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W D + + N+ D + G+ L +R ++ D G D+ +A + V E
Sbjct: 3036 VHWFLDKTPLHANELNEIDAQPGGY-HVLTLRQLALKDSGTIYFEAGDQRASAALRVTEK 3094
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P L + + +G T E + D V W KDG ++ S QL+ +G + +L I
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSHEGHRAQLLI 3154
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
L D+G Y CE G + ++I+ V + F L + ++ A L +
Sbjct: 3155 TGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGGA-ATLRCVLSSVAA 3213
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
V W +V+ +K++L + L++R D Y+C D TT + V
Sbjct: 3214 PVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD--QTTSATLTVTA 3271
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P + + R G+ TL + +A P EW S+ ++ D
Sbjct: 3272 LPAQFIGKLRNKEATEGATATLRCELSKAAPV---EWRKGSETLRDGDRYCLRQDGAMCE 3328
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
L I+ + DA Y CG ++TI P+
Sbjct: 3329 LQIRGLAMVDAAEYSC----VCGEERTSASLTIRPMPA 3362
Score = 131 bits (316), Expect = 3e-29
Identities = 147/691 (21%), Positives = 264/691 (38%), Gaps = 38/691 (5%)
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
E GT ++ +TWY++ + +S S + G LV+ + D+G+Y
Sbjct: 1547 EAGTSATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEA-GQADAGEYS 1605
Query: 906 CVASNSAGKSSHGARVTIDVEKVTFVKH--LQKSYETEEGKTVILECQTSHT-VSTKWYH 962
C AG + + KV F K + + E G + L C+ + WY
Sbjct: 1606 C----KAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYK 1661
Query: 963 NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRK 1022
+ K++S + G + G C Q+ S L V E P+ +
Sbjct: 1662 DGKKLSSSSKVRVEAVGCTRRLVVQQAGQAEAGEYSCEAGGQQLSFRLQVAELEPQISER 1721
Query: 1023 ---LQDFEVKEKDVAILEVEINSETA-DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRN 1078
+ VKE + IL + + +A V W +DG I+ K +++ +G L +
Sbjct: 1722 PCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSK-RHETASQGDTHTLTVHG 1780
Query: 1079 TSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR 1138
V D YSC + E V V E+ + L+ G T EL+ A V
Sbjct: 1781 AQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSPACAEVV 1840
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPS-IN 1197
W ++++ Q+ +G + L + +DAGEY CE + +A LTV P +
Sbjct: 1841 WRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVK 1900
Query: 1198 FTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRK 1257
F L + + V P + + V W++ ++++ +EKF + +L I
Sbjct: 1901 FMSGLSTVVAEEGGEATFQCVVSPSD-VAVVWFRDGALLQPSEKFAISQSGASHSLTISD 1959
Query: 1258 CTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQP 1317
+D + T A S+ L+V E P ++ S VTL V+ P P
Sbjct: 1960 LVLEDAGQITVEAEGASSSAALRVR--EAPVLFKKKLEPQTVEERSSVTLEVELTR-PWP 2016
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
W N+ + K+ + + L + V D G + ++ A + + +
Sbjct: 2017 ELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQ 2076
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQ 1437
+ E ++++ + + G+ T + +Q+ T ++V+ T
Sbjct: 2077 VRLVRGLQAVEAREQGTATMEVQLSHADVDGSWT--RDGLRFQQGPTCH-LAVRGPMHTL 2133
Query: 1438 TSIQNLKTNSS--YRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
T + L+ S F+A V+ T V+ E + + +PL+++ T
Sbjct: 2134 T-LSGLRPEDSGLMVFKAEGVH----------TSARLVVTELPV---SFSRPLQDVVTTE 2179
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK 1526
E + L C P V W +DG +L+ K
Sbjct: 2180 KEKVTLECELSR-PNVDVRWLKDGVELRAGK 2209
Score = 126 bits (305), Expect = 7e-28
Identities = 122/542 (22%), Positives = 224/542 (41%), Gaps = 23/542 (4%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTL 805
G S LS +V + +TW K+ K + + + ++ G T + + + + D G Y+
Sbjct: 1549 GTSATLSCEVA-QAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQA-DAGEYSC 1606
Query: 806 KAENSEGIAETSAVITVEEPTEENA-EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
KA G S + V EP A E P +E+ + + L V + +
Sbjct: 1607 KA----GDQRLSFHLHVAEPKVVFAKEQPAH----REVQAEAGASATLSCEVAQAQT-EV 1657
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
TWY++ + +S S + G LV+ + ++G+Y C A + S +V
Sbjct: 1658 TWYKDGKKLSSSSKVRVEAVGCTRRLVVQQA-GQAEAGEYSCEAGGQ--QLSFRLQVAEL 1714
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXX 982
+++ ++ +E + +IL T + W + EI E +G
Sbjct: 1715 EPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTH 1774
Query: 983 XXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS 1042
D + C V + + V+E +F R L+ + L E++
Sbjct: 1775 TLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSP 1834
Query: 1043 ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
A+VVW ++ K ++ G +R L + D GEY C RD+ +A++TV
Sbjct: 1835 ACAEVVWRCGNTQLRVGK-RFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTV 1893
Query: 1103 -VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
V + ++ L +G +ATF+ ++ D V WF+DG+ +Q S ++ G
Sbjct: 1894 SVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASH 1953
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP 1221
L I D L+DAG+ + E + +A L V E + F +L E V + L VE+
Sbjct: 1954 SLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL-EPQTVEERSSVTLEVELT 2012
Query: 1222 DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
++ W + + + + + ++ + L++ D+ + C D K+ KL V
Sbjct: 2013 RPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTV 2072
Query: 1282 EV 1283
E+
Sbjct: 2073 EM 2074
Score = 122 bits (293), Expect = 2e-26
Identities = 206/1051 (19%), Positives = 385/1051 (36%), Gaps = 70/1051 (6%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
K P+ V G D + C +A+P + WL EE+V ++++ E H L I
Sbjct: 425 KLPRKTAVRVG-DTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRH----TLTI 479
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVRQGESVILSA 756
+ G +A G+ + K P Q ++P+ R SVILS
Sbjct: 480 SQCCLEDVGQVAFMA----GDCQTSTQFCVSAPRKPPLQPPVDPVVK--ARMESSVILSW 533
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT-ILKPK----KVKDEGVYTLKAENSE 811
+ +T K L T + H + P+ V +EG + +
Sbjct: 534 SPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALN 593
Query: 812 GIAETSAVITVEEPTEENAEPPLFINR-FQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
++ + E P + P L + + + E G + +T + W+ +
Sbjct: 594 SFGQSPYL---EFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLT--VASAGEWFLDG 648
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN--SAGKSSHGARVTIDVEKV 928
+ + S + D L I V + + K VA+ S+ + A + K
Sbjct: 649 QALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKP 708
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ E ++ E + + W + + +S E+
Sbjct: 709 PAAAAREVLARLHEEAQLLAEL-SDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRD 767
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQD---FEVKEKDVAILEVEINSETA 1045
D G+ +C+ + + L V + + F+ K + A E E +
Sbjct: 768 VARDDAGLYECVSRGGRIAYQLSV-QGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHV 826
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W +DG + ++ E G +L + DEG YSC + ++S + V E
Sbjct: 827 HVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSE- 885
Query: 1106 PPEII---TRLQNQKVNK--GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKK 1160
P+++ +L +K+ G AT E+ + V W+KDG ++ S+ + + G
Sbjct: 886 -PKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944
Query: 1161 QKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR--LPEFILVPANTDAYLTV 1218
++L + DAGEYSCE G + + L V+EP + F + A A L+
Sbjct: 945 RRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSC 1004
Query: 1219 EIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK 1278
E+ +V WYK + + K + + +R L++++ + D +Y+C + + +
Sbjct: 1005 EVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFR 1064
Query: 1279 LKV-EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
L + E K E + + G+ L + A Q W + K +
Sbjct: 1065 LHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGME 1123
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
+ + L + + DAG Y G V ++ I + P G + + S
Sbjct: 1124 VKGCTRRLVLPQAGKADAGEYSC----EAGGQRVSFHLHITE---PKG---VFAKEQSVH 1173
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVN 1457
N + G + ++ V + + T + K ++ + +K + R V
Sbjct: 1174 N---EVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVK-GCTRRLVVQQVG 1229
Query: 1458 EVDISDASETTEYYKVIKETKIQSPTV----EKPLKN-ITTEPNEDIELTCIFGGVPQPK 1512
+ D + S +V + I P E+ + N + TE L+C Q +
Sbjct: 1230 KADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQA-QTE 1288
Query: 1513 VTWYRDGKKL-KTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
VTWY+DGKKL ++K E Y C A G S + +
Sbjct: 1289 VTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEA----GGQRLSFHLDVS 1344
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+ + + +K + + T E EV WYK+G KL + + + T
Sbjct: 1345 EPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCT 1404
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
+ +++ ++ + +Y+ EA + S++V
Sbjct: 1405 RRLVVQQACQADTGEYSCEAGGQRLSFSLDV 1435
Score = 122 bits (293), Expect = 2e-26
Identities = 150/720 (20%), Positives = 283/720 (39%), Gaps = 38/720 (5%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSV-LKITNVKKFQ 704
+ G+ L C VA + ++ W G+++ + V +E+ + C+ L + +
Sbjct: 1547 EAGTSATLSCE-VAQAQTEVTWYKDGKKL--SSSSKVRMEA---VGCTRRLVVQEAGQAD 1600
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G Y+ A ++ L + KE P E + G S LS +V +
Sbjct: 1601 AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEVA-QAQT 1655
Query: 765 TITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
+TW K+ K + + + ++ G T + + + + + G Y+ +A G + S +
Sbjct: 1656 EVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQA-EAGEYSCEA----GGQQLSFRLQ 1710
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
V E + +E P R + + VKE I L A + ++TW ++ I S+
Sbjct: 1711 VAELEPQISERPC---RREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHET 1767
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE 941
G+ L + +DS Y C G V ++ F + L+ E
Sbjct: 1768 ASQGDTHTLTVHGAQV-LDSAIYSC----RVGAEGQDFPVQVEEVAAKFCRLLEPVCG-E 1821
Query: 942 EGKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
G TV L C+ S + W ++ +++ EG D G C
Sbjct: 1822 LGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCE 1881
Query: 1001 VKDQETSTMLVVK-ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPK 1059
+D TS L V + +F+ L +E A + ++ VVW RDG +++P
Sbjct: 1882 SRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPS 1941
Query: 1060 KNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVN 1119
+ K+ + G L I + + D G+ + S +A + V E P +L+ Q V
Sbjct: 1942 E-KFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVE 2000
Query: 1120 KGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE 1179
+ + T E+ELT+ +RW ++ + + ++++ +G + +L +++ D G + CE
Sbjct: 2001 ERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCE 2060
Query: 1180 VGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDT 1239
+ K A LTVE + L + + A + V++ +D +W + +
Sbjct: 2061 TPDDKTQAKLTVEMRQVRLVRGL-QAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQQG 2119
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKST-TKLKVEVVEFPPKIVDYEREYR 1298
L TL + +D ++ A+ T ++ V E P ++
Sbjct: 2120 PTCHLAVRGPMHTLTLSGLRPEDS---GLMVFKAEGVHTSARLVVTELPVSFSRPLQDVV 2176
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
VTL + P + W+ + ++ K + SLTI + E D G+Y
Sbjct: 2177 TTEKEKVTLECELSR-PNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVY 2235
Score = 115 bits (277), Expect = 2e-24
Identities = 136/655 (20%), Positives = 244/655 (37%), Gaps = 46/655 (7%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSIT 790
P PL+ ++ + E V L ++ P + W K+ ++A T + G S+T
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLECEL-SRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLT 2223
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAV----------ITVEEPTE-----ENAE---- 831
I + + D+GVY A +++ A + E+ E ENAE
Sbjct: 2224 IYRCE-FADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQ 2282
Query: 832 ------PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
P + ++ EK L +V+R + W++ ++ + P DG
Sbjct: 2283 LRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASA-QVRWFKGSQELQPGPKYELVSDG 2341
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+L+I++V +E D Y C AG A+ ++ + +T V+ LQ E
Sbjct: 2342 LYRKLIISDVHAE-DEDTYTC----DAGDVKTSAQFFVEEQSITIVRGLQ-DVTVMEPAP 2395
Query: 946 VILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
EC+TS KW K + + + QEG G + V
Sbjct: 2396 AWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGK 2455
Query: 1004 QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY 1063
+S LVV + R L+ +E +L + V W +D + P + K+
Sbjct: 2456 SRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQWYKDDTPLSPSE-KF 2514
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
G + +L I D G Y C + EVTV + LQ+ + +
Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEEGW 2574
Query: 1124 ATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
A+F EL+ D V W +G + + +++ G++ L + DAG
Sbjct: 2575 ASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKV 2634
Query: 1184 KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFT 1243
+A L V + F L + T A L E+ D V W K + ++K+
Sbjct: 2635 STSARLEVRVKPVVFLKALDDLSAEERGTLA-LQCEVSDPEAHVVWRKDGVQLGPSDKYD 2693
Query: 1244 LISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGS 1303
+ R L++ + +D YTC + T+ +V V + I + + G
Sbjct: 2694 FLHTAGTRGLVVHDVSPEDAGLYTCHV--GSEETRARVRVHDLHVGITKRLKTMEVLEGE 2751
Query: 1304 DVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAG 1356
+ ++ +++ P W V K + + + + L +++ +DAG
Sbjct: 2752 SCSFECVLSHESASDP-AMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAG 2805
Score = 105 bits (253), Expect = 1e-21
Identities = 83/355 (23%), Positives = 147/355 (41%), Gaps = 38/355 (10%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P+ AP+F+ +L+ + DG V F+C V G P P + WF+ +++ + +
Sbjct: 5117 PSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINE 5176
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDH--GSEMTVXXXXX 618
D L+I V P D G + C+A+N+ G +S+ EL V+ +D+ ++ T
Sbjct: 5177 DQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYF 5236
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL---------ECRLVAIPEPDIAWLF 669
+ EG T + Q V+E D+ + + ++ P P + W
Sbjct: 5237 SAQGYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFK 5296
Query: 670 KGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT 729
G+ + +I + + +H L+I +V + G Y N G A L ++
Sbjct: 5297 DGQPLTASAHIRMTDKKILH----TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRG 5352
Query: 730 GEKE-------------PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
++ PP+++E V++G S+ S +V G P PT+ W +
Sbjct: 5353 PDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERG 5412
Query: 777 AL---------PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
L S HS+ +L + + +G YT A N+ G A SA + V
Sbjct: 5413 VLWIGPDTPGYTVASSAQQHSLVLLDVGR-QHQGTYTCIASNAAGQALCSASLHV 5466
Score = 104 bits (250), Expect = 3e-21
Identities = 162/749 (21%), Positives = 289/749 (38%), Gaps = 66/749 (8%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+EG + +C +V+ + + W G + P E +++ H L I+++
Sbjct: 1911 EEGGEATFQC-VVSPSDVAVVWFRDGALLQPSEKFAISQSGASHS----LTISDLVLEDA 1965
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G TV A EG AS L+++ + P + L+ V + SV L ++ P P
Sbjct: 1966 GQITVEA---EG-ASSSAALRVR---EAPVLFKKKLEPQTVEERSSVTLEVELT-RPWPE 2017
Query: 766 ITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+ W +N P K + ++G H + +L D G + + + + T A +TV
Sbjct: 2018 LRWTRNATALAPGKNVEIHAEGARHRL-VLHNVGFADRGFFGCETPDDK----TQAKLTV 2072
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E + Q + +E+GT + +++ V +W R+ T
Sbjct: 2073 E------MRQVRLVRGLQAVEAREQGTATMEVQLSHADVDG-SWTRDGLRFQQGPTCHLA 2125
Query: 883 FDGENIELVITNVDSEIDSG-----------DYKCVASNSAGKSSHGAR--VTIDVEKVT 929
G L ++ + E DSG + V + S + VT + EKVT
Sbjct: 2126 VRGPMHTLTLSGLRPE-DSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVT 2184
Query: 930 F----------VKHLQKSYETEEGKTVILECQ---TSHTVSTKWYHNKKEI-----SGMD 971
V+ L+ E GKT+ + Q S T+ + ++
Sbjct: 2185 LECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQS 2244
Query: 972 HREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+ +GR D G I+ + ++ E+ L VKE +R L+D EK
Sbjct: 2245 SASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEK 2304
Query: 1032 DVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
+LE +++ +A V W + + ++P KY+ G RKL I + DE Y+C
Sbjct: 2305 HRGVLECQVSRASAQVRWFKGSQELQPGP-KYELVSDGLYRKLIISDVHAEDEDTYTCDA 2363
Query: 1092 RDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSN 1150
D +A+ V E I+ LQ+ V + A FE E + +W + +Q
Sbjct: 2364 GDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGG 2423
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPA 1210
++ L +G +L + G VG S+ +A L V + + T L E
Sbjct: 2424 NVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPL-EPKTGRE 2482
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
L+ + V WYK + + +EKF + + + L I + D Y C
Sbjct: 2483 LQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 2542
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
A S+T++ VE E + E + + + + ++ EW +N +
Sbjct: 2543 GSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYN 2599
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
+ S + +L +K ++ DAGI +
Sbjct: 2600 DSFHEISHKGRRHTLVLKSIQRADAGIVR 2628
Score = 98.3 bits (234), Expect = 3e-19
Identities = 119/564 (21%), Positives = 219/564 (38%), Gaps = 39/564 (6%)
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVK 798
++ V +G+ LS V G P+P W K+ + V + D + + + K
Sbjct: 245 RTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
D G+YT A N G +S ++ V EP A P F R Q++ V+EK + + V +
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLVVVREP----AVP--FKKRLQDLEVREKESATFLCEVPQ 358
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P W++ + S +G L + NV ++ D Y C ++ G
Sbjct: 359 -PSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSAD-DDAVYIC-------ETPEG 409
Query: 919 ARVTIDVE-KVTFVKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISGMDHREII 976
+R ++ + ++ L + G T + + + V W N++E+ I
Sbjct: 410 SRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAIS 469
Query: 977 QEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEK-DVAI 1035
EG DVG + + D +TST V ++ D VK + + ++
Sbjct: 470 AEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSV 529
Query: 1036 LEVEINSETADVVWERDGEIIKPKK-NKYDF---EKRGHIRKLYIRNTSVHDEGEYSCIL 1091
+ + DG +++ KK Y + + + + V +EG + +
Sbjct: 530 ILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRV 589
Query: 1092 RDESCTAEVTVVELP------PEIITR--LQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ + +E P P++ R L+ + +G + TF ++LT A WF DG
Sbjct: 590 SALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASA-GEWFLDG 648
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
++ S+ ++ D + L I + G V N ++I + T P
Sbjct: 649 QALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKP 708
Query: 1204 -----EFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
+L + +A L E+ D+ VTW K + K+ + + +R L++R
Sbjct: 709 PAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDV 768
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVE 1282
DD Y CV + +L V+
Sbjct: 769 ARDDAGLYECVSRGGRIAYQLSVQ 792
Score = 89.4 bits (212), Expect = 1e-16
Identities = 108/524 (20%), Positives = 208/524 (39%), Gaps = 37/524 (7%)
Query: 1139 WFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEE 1193
W KDG + + H+ + LKI C D G Y+C VG + + ++ V E
Sbjct: 271 WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVRE 330
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
P++ F RL + + V A E+P + + W+K+++ + + K+ + + +R L
Sbjct: 331 PAVPFKKRLQD-LEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRL 389
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQA 1313
+R + DD Y C + T E+ + R+ ++ G V+ A
Sbjct: 390 TVRNVSADDDAVYICETPEGSRTV---AELAVQGNLLRKLPRKTAVRVGDTAMFCVEL-A 445
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P W+ N + + S + +LTI + D G + +C +
Sbjct: 446 VPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAF-MAGDC-QTSTQF 503
Query: 1374 NVTILDKP--SPPGKPNILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTTEWI-- 1428
V+ KP PP P + SS+ + W P + TI Y+VE +++ T WI
Sbjct: 504 CVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRC 563
Query: 1429 -SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP 1487
+ + + ++ ++ +++FR A+N S E + + +++P K
Sbjct: 564 HEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPL--KA 621
Query: 1488 LKNIT-TEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXX 1543
++ + E ++LT G W+ DG+ LK A + YE +R
Sbjct: 622 VQAVEGGEVTFSVDLTVASAG------EWFLDGQALK-ASSVYEIHCDRTRHTLTIREVP 674
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV----GDEWLVTAVIEGI 1599
+ F +G +E+S + ++ P +T + +V +E + A +
Sbjct: 675 ASLHGAQLKFVANG-IESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSD- 732
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY 1643
V W K+G L +Y + V+ ++++ R + Y
Sbjct: 733 QAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLY 776
Score = 81.4 bits (192), Expect = 3e-14
Identities = 54/209 (25%), Positives = 96/209 (45%), Gaps = 15/209 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F +PKA V G D L C++V P P ++W + + +A + D++
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYR--- 66
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT----GEKEPPQVIEPLKSMIVRQG 749
L I ++ G Y A N GEA + L++ E+ P ++ P S+ VR+G
Sbjct: 67 -LTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRP-TSIRVREG 124
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTHSITILKPKKVKDEGVYT 804
+V G+PRP ++W K+ + + + + G+ ++ I + + +D G Y
Sbjct: 125 SEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRI-RAARPRDGGTYE 183
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPP 833
++AEN G A +A + V+ + A P
Sbjct: 184 VRAENPLGAASAAAALVVDSDAADTASRP 212
Score = 81.0 bits (191), Expect = 4e-14
Identities = 90/392 (22%), Positives = 152/392 (38%), Gaps = 27/392 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVAT 567
AP F+ + +GS F C+V G PRP ++W + + ++ ++ +
Sbjct: 109 APHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASA 168
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
L IR P D GT+ A+N G AS+ L+V++ +D S +
Sbjct: 169 LRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRRE 228
Query: 628 IL--EGIPPT-FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
+ EG P + S + V EG L C + P+P+ W K ++V + V
Sbjct: 229 AMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWK-KDGQLVTEGRRHVVY 287
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + VLKI K+ G YT A N G+ +++ ++ E P + L+ +
Sbjct: 288 EDAQENF--VLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR--EPAVP-FKKRLQDL 342
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEG 801
VR+ ES + V P W K + A + +G +T+ + D+
Sbjct: 343 EVREKESATFLCE-VPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTV-RNVSADDDA 400
Query: 802 VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPV 861
VY E EG + T A + V+ + + T G + PV
Sbjct: 401 VYI--CETPEG-SRTVAELAVQGN---------LLRKLPRKTAVRVGDTAMFCVELAVPV 448
Query: 862 PSITWYRNNEIISPSETITQNFDGENIELVIT 893
+ W RN E + + + +G L I+
Sbjct: 449 GPVHWLRNQEEVVAGGRVAISAEGTRHTLTIS 480
Score = 78.6 bits (185), Expect = 2e-13
Identities = 55/195 (28%), Positives = 89/195 (45%), Gaps = 7/195 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P+ + K+ +V G+ LS Q+VGNP P ++W K+ +PV A DGD + +TI
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIK 851
L + D G Y +A N+ G A + + V+ + P F+ R I V+E
Sbjct: 70 L-DLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 852 LVARVTRNPVPSITWYRNNEIISPSETITQNFD--GENIELVITNVDSEIDSGDYKCVAS 909
RV +P P+++W ++ + + + GE L I D G Y+ A
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPR-DGGTYEVRAE 187
Query: 910 NSAGKSSHGARVTID 924
N G +S A + +D
Sbjct: 188 NPLGAASAAAALVVD 202
Score = 71.7 bits (168), Expect = 3e-11
Identities = 57/248 (22%), Positives = 106/248 (42%), Gaps = 8/248 (3%)
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI---LRDESCTAEVTV 1102
+ VW++DG+++ + +E L I D G Y+C L ++ ++ + V
Sbjct: 268 ETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVV 327
Query: 1103 VELPP-EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
V P RLQ+ +V + ATF E+ + WFK+ + + S + +G ++
Sbjct: 328 VREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTER 387
Query: 1162 KLKIYDCDLDDAGEYSCEV-GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+L + + DD Y CE S+ A L V+ N +LP V A VE+
Sbjct: 388 RLTVRNVSADDDAVYICETPEGSRTVAELAVQG---NLLRKLPRKTAVRVGDTAMFCVEL 444
Query: 1221 PDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLK 1280
V W + + + + + ++ + TL I +C +D + + D +++T+
Sbjct: 445 AVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFC 504
Query: 1281 VEVVEFPP 1288
V PP
Sbjct: 505 VSAPRKPP 512
Score = 70.5 bits (165), Expect = 6e-11
Identities = 60/207 (28%), Positives = 95/207 (45%), Gaps = 22/207 (10%)
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVI-LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDT- 786
T E + PQV+E L+ + V G + +V G P P + W K+ +P+ A D
Sbjct: 5254 TDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKK 5313
Query: 787 --HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV---EEPTEENAE-------PPL 834
H++ I+ + +D G Y N+ G A +SA + V +EP E+ A PP
Sbjct: 5314 ILHTLEIISVTR-EDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPR 5372
Query: 835 FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-----IISP-SETITQNFDGENI 888
+ RF VK+ +I +V PVP++ W R I P + T +
Sbjct: 5373 MLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQH 5432
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKS 915
LV+ +V + G Y C+ASN+AG++
Sbjct: 5433 SLVLLDVGRQ-HQGTYTCIASNAAGQA 5458
Score = 68.5 bits (160), Expect = 2e-10
Identities = 50/194 (25%), Positives = 79/194 (40%), Gaps = 11/194 (5%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK---SDGDTHSIT 790
PP E L GE+V L+ +V G P+P I+W K+ K V+ P D D
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
IL D G Y A ++ G T I V+ PP F+N+ + E
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ-------VPPRFVNKVRASPFVEGEDA 6125
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETI-TQNFDGENIELVITNVDSEIDSGDYKCVAS 909
+ + P P I WY++ +++ T + + +++ S+ D G Y+C
Sbjct: 6126 QFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELV 6185
Query: 910 NSAGKSSHGARVTI 923
N G + A + I
Sbjct: 6186 NRLGSARASAELRI 6199
Score = 68.1 bits (159), Expect = 3e-10
Identities = 33/96 (34%), Positives = 49/96 (51%), Gaps = 1/96 (1%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATL 568
P FV K+R +G QF C +EG P PQI W++ A++ FQ + + L
Sbjct: 6108 PRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVL 6167
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
VIR ED G + C N G A ++ EL +++P+
Sbjct: 6168 VIRAASKEDLGLYECELVNRLGSARASAELRIQSPM 6203
Score = 64.9 bits (151), Expect = 3e-09
Identities = 43/188 (22%), Positives = 76/188 (40%), Gaps = 9/188 (4%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK-----ATYENRXXXX 1536
P E+ L + T E E ++L C G P+P ++WY+DGK ++ +
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVI 1596
Y C A + G T + +Q P N+ G++ T I
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPP--RFVNKVRASPFVEGEDAQFTCTI 6131
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTS--VIRIKELKRSHSSKYTIEASNTAGTS 1654
EG P P++ WYK+G L ++ ++ ++ V+ I+ + Y E N G++
Sbjct: 6132 EGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSA 6191
Query: 1655 SVEVTLKV 1662
L++
Sbjct: 6192 RASAELRI 6199
Score = 61.3 bits (142), Expect = 4e-08
Identities = 57/221 (25%), Positives = 89/221 (40%), Gaps = 26/221 (11%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F+ + + G CQ+ G P PQ++W + + F++ D D +
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGD-LY 65
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
L I ++ D+G + C A+NA G A + L V+A + +E
Sbjct: 66 RLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAA--CAEQA-------------- 109
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
P F +P + V EGS+ CR+ P P ++W G + + V +E
Sbjct: 110 -------PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEE 162
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
S L+I + GTY V A N G AS L +
Sbjct: 163 LGE--ASALRIRAARPRDGGTYEVRAENPLGAASAAAALVV 201
Score = 60.1 bits (139), Expect = 9e-08
Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 7/156 (4%)
Query: 1597 EGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
E +P E WY NG ++ +D ++ +T + ++ + H+ + T + ++
Sbjct: 4457 EAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASAR 4516
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
+ V L + D P E V+ R S +VT+ W P+ DGG L Y +E E +W
Sbjct: 4517 LTV-LGLPDPPEDAE--VVAR--SSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRL 4571
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE 1751
++ E + L Y FRV A PVG E
Sbjct: 4572 CHELVPGPEC-VVDGLAPGETYRFRVAAVGPVGAGE 4606
Score = 59.3 bits (137), Expect = 1e-07
Identities = 50/213 (23%), Positives = 98/213 (46%), Gaps = 10/213 (4%)
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS--PSETITQNFDGENIE 889
PP F + T + T+KL RVT P P I+WY++ + + P + ++ DG +
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDG-SCA 6071
Query: 890 LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILE 949
L++ ++ +DSG Y C A+++AG S ++ + V FV ++ S EG+
Sbjct: 6072 LILDSLTG-VDSGQYMCFAASAAGNCSTLGKILVQVPP-RFVNKVRAS-PFVEGEDAQFT 6128
Query: 950 C--QTSHTVSTKWYHNKKEISGMDHREIIQEGRX--XXXXXXXXXXXDVGVIKCIVKDQE 1005
C + + +WY + ++ + + + E R D+G+ +C + ++
Sbjct: 6129 CTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRL 6188
Query: 1006 TSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
S + I + + Q+ +E+ VA +EV
Sbjct: 6189 GSARASAELRIQSPMLQAQEQCHREQLVAAVEV 6221
Score = 57.2 bits (132), Expect = 6e-07
Identities = 27/94 (28%), Positives = 48/94 (51%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F E+L G TV+ C+V G P+P I+W++ ++ + D D L+
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ + D+G + C A +AAG S+ +++V+ P
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVP 6107
Score = 55.2 bits (127), Expect = 2e-06
Identities = 43/197 (21%), Positives = 86/197 (43%), Gaps = 11/197 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F ++ + G + L CR+ P+P I+W G+ + D + + IE D C
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPH-HILIE-DPDGSC 6070
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+++ + ++ G Y A + G S + ++ PP+ + +++ +GE
Sbjct: 6071 ALI-LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQV----PPRFVNKVRASPFVEGEDA 6125
Query: 753 ILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTH-SITILKPKKVKDEGVYTLKAE 808
+ + G P P I W K+ + T S+ + + +++ +D G+Y +
Sbjct: 6126 QFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELV 6185
Query: 809 NSEGIAETSAVITVEEP 825
N G A SA + ++ P
Sbjct: 6186 NRLGSARASAELRIQSP 6202
Score = 54.4 bits (125), Expect = 4e-06
Identities = 30/119 (25%), Positives = 54/119 (45%), Gaps = 3/119 (2%)
Query: 815 ETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
ET A + EP + P+F+ Q V++ + VT P+PS+ W+++ +
Sbjct: 5105 ETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGK 5164
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
++ + N D + +I D G Y+C+A NS G SS A + +D+ +
Sbjct: 5165 LLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDY 5223
Score = 53.2 bits (122), Expect = 1e-05
Identities = 69/334 (20%), Positives = 125/334 (37%), Gaps = 24/334 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
+Q P+F G ++ EC V + W + + + + D
Sbjct: 4893 KQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDG 4952
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I + DAG +TC N G + + ++V GSE
Sbjct: 4953 TCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVVVS------GSESEAESSSGGELDDA 5006
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLEC-RLVAIPEPDIAW-LFKGEE---IVPDEN 679
+ F K A+ DE ++ L A PE W ++ +E + E
Sbjct: 5007 FRRAARRLHRLFRTKSPAEVSDE--ELFLSADEGPAEPEEPADWQTYREDEHFICIRFEA 5064
Query: 680 ISVA---IESDMHMYCSVLKITNVKKFQEGTYTV-VAVNREGEASL--PIVLKIKTGEKE 733
++ A + M+ ++ +K ++G V + +++E A + P L
Sbjct: 5065 LTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDA 5124
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHSI 789
P + L++ V+ G V V G P P++ W K+ K ++ + + H +
Sbjct: 5125 APVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
I+ D GVY AENS G++ T A + V+
Sbjct: 5185 -IITAVVPADMGVYRCLAENSMGVSSTKAELRVD 5217
Score = 48.8 bits (111), Expect = 2e-04
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 6/118 (5%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHE 1924
P P + V +S +VTL W P S+GG + Y +E K W V G E
Sbjct: 4523 PDPPEDAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGP--E 4580
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRL-EKHATVPSPPTAPLEIRMVGS 1980
++ + + FR++A VG P Q+VRL E VP P+AP E R V +
Sbjct: 4581 CVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-ESRQVAA 4637
Score = 46.8 bits (106), Expect = 9e-04
Identities = 35/155 (22%), Positives = 57/155 (36%), Gaps = 4/155 (2%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKR-TLIIRKCTEDDQCEYTCVLLDAKST-TKLKVEVV 1284
++WYK ++ LI D LI+ T D +Y C A + L +V
Sbjct: 6045 ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILV 6104
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA- 1343
+ PP+ V+ R G D + P P W + ++ + + +S
Sbjct: 6105 QVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL 6164
Query: 1344 -SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
L I+ D G+Y+ L N G A + I
Sbjct: 6165 LVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/180 (23%), Positives = 75/180 (41%), Gaps = 15/180 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F+ + + F V A L +I + T V WE+D + + ++ + G + +L
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGA-RFRLAQDGDLYRLT 68
Query: 1076 IRNTSVHDEGEYSCILRDE----------SCTAEVTVVELPPEIITRLQNQKVNKGNKAT 1125
I + ++ D G+Y C R+ AE E P + R + +V +G++AT
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 1126 FEIELTKGD-ALVRWFKDGSEIQFSNHIQLTID--GKKQKLKIYDCDLDDAGEYSCEVGN 1182
F + V W KDG + + ++ ++ G+ L+I D G Y N
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAEN 188
Score = 46.0 bits (104), Expect = 0.001
Identities = 48/203 (23%), Positives = 78/203 (38%), Gaps = 13/203 (6%)
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP+ L + G +T ++ W+KDG +Q H L D
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 1165 IYDCDLD-DAGEYSC----EVGN-SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I D D+G+Y C GN S IL P +R F+ DA T
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFV---EGEDAQFTC 6129
Query: 1219 EIPDETL-DVTWYKKKSVIEDTEKFTLISDVKK--RTLIIRKCTEDDQCEYTCVLLDAKS 1275
I + WYK +++ KF +S+ + L+IR +++D Y C L++
Sbjct: 6130 TIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLG 6189
Query: 1276 TTKLKVEVVEFPPKIVDYEREYR 1298
+ + E+ P + E+ +R
Sbjct: 6190 SARASAELRIQSPMLQAQEQCHR 6212
Score = 45.6 bits (103), Expect = 0.002
Identities = 45/201 (22%), Positives = 81/201 (40%), Gaps = 15/201 (7%)
Query: 1200 LRLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
L P+ +V DA L+ +I + T V+W K + + +F L D L I
Sbjct: 13 LTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDL 72
Query: 1259 TEDDQCEYTC----VLLDAKSTTKLKVEV----VEFPPKIVDYEREYRIKRGSDVTLLVD 1310
D +Y C + +A + L+V+ E P + R++ GS+ T
Sbjct: 73 ALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCR 132
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPSID--SKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P+P W + + + + + ++ ++++L I+ D G Y++R EN G
Sbjct: 133 VGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGA 192
Query: 1369 ADVEMNVTI----LDKPSPPG 1385
A + + D S PG
Sbjct: 193 ASAAAALVVDSDAADTASRPG 213
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+ L PK + +V C P+ + W++ + PS+ F+M + +A L I
Sbjct: 2470 VLTRPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQ-MAELRI 2527
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+ P DAG + C AG A S+TE+ VEA
Sbjct: 2528 LRLMPADAGVYRC----QAGSAHSSTEVTVEA 2555
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/90 (30%), Positives = 41/90 (45%)
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
PE V A D L +E+ E +V W+K I+ +F ++S +++ L+I+ T +D
Sbjct: 4630 PESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAED 4689
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
Q EY C L V P VD
Sbjct: 4690 QGEYHCGLAQGSICPAAATFQVALSPASVD 4719
Score = 44.0 bits (99), Expect = 0.006
Identities = 27/95 (28%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 1092 RDESCTAEVTVVELPPEIITRLQNQKVNKGNK-ATFEIELTKGDALVR--WFKDGSEIQF 1148
R++ T T P+++ L++ +V G + A F++++ KG R WFKDG +
Sbjct: 5245 REQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKV-KGYPAPRLYWFKDGQPLTA 5303
Query: 1149 SNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
S HI++T L+I +D+G+Y+ + N+
Sbjct: 5304 SAHIRMTDKKILHTLEIISVTREDSGQYAAYISNA 5338
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 1031 KDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI 1090
+DV+ LE+E+ +E +V+W + E I+P +++ +G + L I+ + D+GEY C
Sbjct: 4639 EDVS-LELEVVAEAGEVIWHKGMERIQP-GGRFEVVSQGRQQMLVIKGFTAEDQGEYHCG 4696
Query: 1091 LRDES-CTAEVTV-VELPP 1107
L S C A T V L P
Sbjct: 4697 LAQGSICPAAATFQVALSP 4715
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 1965 VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTL 2024
+P PP E+ S+ V SW P DGG L GY + +++ W ++ V
Sbjct: 4522 LPDPPE-DAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHEL-VPGP 4579
Query: 2025 KFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
+ + L+ TY R+ A +G EP+
Sbjct: 4580 ECVVDGLAPGETYRFRVAAVGPVGAGEPV 4608
Score = 42.7 bits (96), Expect = 0.014
Identities = 28/80 (35%), Positives = 40/80 (50%), Gaps = 4/80 (5%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGK-KQKL 1163
P +T LQNQ+V G +F+ +T G + VRWFKDG ++ +H + D + +L
Sbjct: 5126 PVFLTELQNQEVQDGYPVSFDCVVT-GQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184
Query: 1164 KIYDCDLDDAGEYSCEVGNS 1183
I D G Y C NS
Sbjct: 5185 IITAVVPADMGVYRCLAENS 5204
Score = 42.3 bits (95), Expect = 0.018
Identities = 23/94 (24%), Positives = 42/94 (44%), Gaps = 1/94 (1%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVI 892
P F+ R + V L ++ NP P ++W ++ + ++ DG+ L I
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 893 TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
++ DSG Y C A N+ G++ + +D E
Sbjct: 70 LDLALG-DSGQYVCRARNAIGEAFAAVGLQVDAE 102
Score = 41.9 bits (94), Expect = 0.024
Identities = 41/187 (21%), Positives = 67/187 (35%), Gaps = 15/187 (8%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXX 1544
K +D L+C G P P+V+W +D + + A +
Sbjct: 17 KAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGD 76
Query: 1545 XXXYKCIAFNDHGEVETSCVVGI-------QQKPVITISNEDIKQKHKVGDEWLVTAVIE 1597
Y C A N GE + + + +Q P + I+ + G E +
Sbjct: 77 SGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVRE--GSEATFRCRVG 134
Query: 1598 GIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
G P P V W K+G +L + +E + S +RI+ + Y + A N G +S
Sbjct: 135 GSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAAS 194
Query: 1656 VEVTLKV 1662
L V
Sbjct: 195 AAAALVV 201
Score = 41.9 bits (94), Expect = 0.024
Identities = 30/102 (29%), Positives = 38/102 (37%), Gaps = 2/102 (1%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
IL +PP F K +A EG D C + P P I W G + E
Sbjct: 6102 ILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPR 6161
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT 729
+ VL I K G Y VNR G A L+I++
Sbjct: 6162 SGLL--VLVIRAASKEDLGLYECELVNRLGSARASAELRIQS 6201
Score = 40.7 bits (91), Expect = 0.056
Identities = 23/81 (28%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-- 1653
++G P P + W+K+G L +T K+ + I + R S +Y SN G
Sbjct: 5284 VKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAY 5343
Query: 1654 SSVEVTLKVYDKP-SKPEGPV 1673
SS + ++ D+P KP V
Sbjct: 5344 SSARLLVRGPDEPEEKPASDV 5364
Score = 39.9 bits (89), Expect = 0.098
Identities = 23/78 (29%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +TR + V+ G AT ++ V W KD + +L DG +L I
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 1166 YDCDLDDAGEYSCEVGNS 1183
D L D+G+Y C N+
Sbjct: 70 LDLALGDSGQYVCRARNA 87
Score = 39.9 bits (89), Expect = 0.098
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 1582 QKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS-VIRIKELKRS 1638
Q +V D + V+ V+ G P P V W+K+G LE D Y I ++ + I + +
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKV 1662
Y A N+ G SS + L+V
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRV 5216
Score = 39.1 bits (87), Expect = 0.17
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F++ L + T+ +C+V P + W + + PS + + LV+
Sbjct: 2648 VFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTA-GTRGLVV 2705
Query: 571 REVFPEDAGTFTC 583
+V PEDAG +TC
Sbjct: 2706 HDVSPEDAGLYTC 2718
Score = 38.7 bits (86), Expect = 0.23
Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 509 API-FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
AP+ F+ +L+ + +G T C++ + W + + + P +QM D A
Sbjct: 3977 APVRFLRELQHQEVDEGGTAHLCCELSR-AGASVEWRKGSLQLFPCAKYQMV-QDGAAAE 4034
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFAS 593
L++R V EDAG +TC + AS
Sbjct: 4035 LLVRGVEQEDAGDYTCDTGHTQSMAS 4060
Score = 38.3 bits (85), Expect = 0.30
Identities = 38/182 (20%), Positives = 71/182 (39%), Gaps = 14/182 (7%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYEN---RXXXXXXXXXXX 1543
+ T + L+C G P+P+ W +DG+ + + YE+
Sbjct: 245 RTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPP- 1602
Y C A N G+ +S +V + ++P + Q +V ++ T + E +P P
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLV-VVREPAVPFKKR--LQDLEVREKESATFLCE-VPQPS 360
Query: 1603 -EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY---TIEASNTAGTSSVEV 1658
E W+K +L +Y I + + ++ + + Y T E S T +V+
Sbjct: 361 TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQG 420
Query: 1659 TL 1660
L
Sbjct: 421 NL 422
Score = 38.3 bits (85), Expect = 0.30
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1114 QNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDA 1173
++++V G + E+E+ V W K IQ ++ G++Q L I +D
Sbjct: 4631 ESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQ 4690
Query: 1174 GEYSCEVG-NSKCTAILTVE 1192
GEY C + S C A T +
Sbjct: 4691 GEYHCGLAQGSICPAAATFQ 4710
Score = 37.5 bits (83), Expect = 0.52
Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
++ + G P PE +W K+G + + + + ++ V++I K+S YT ASN
Sbjct: 257 LSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNL 316
Query: 1651 AGTSSVEVTLKVYDKPSKP 1669
G + V L V +P+ P
Sbjct: 317 VGQTYSSV-LVVVREPAVP 334
Score = 37.5 bits (83), Expect = 0.52
Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F+ L +G F+C V + WFR A+++PS+ F + + +L I
Sbjct: 1901 FMSGLSTVVAEEGGEATFQCVVSPSD-VAVVWFRDGALLQPSEKFAISQSGAS-HSLTIS 1958
Query: 572 EVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++ EDAG T A G +SS + EAP+
Sbjct: 1959 DLVLEDAGQITV---EAEGASSSAALRVREAPV 1988
Score = 37.5 bits (83), Expect = 0.52
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V+F C+V + W Q ++ ++ ++ D + TL ++ V PEDAGT +
Sbjct: 4176 VEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLG 4235
Query: 587 NAAGFASSTT---ELIVEAPLSD 606
N A A T E+ + PL D
Sbjct: 4236 NHASSAQLTVRAPEVTILEPLQD 4258
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 3/54 (5%)
Query: 1131 TKGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+K D RW KDG E+ +HI DG L I D DAG Y+C+V N
Sbjct: 4923 SKADVRARWLKDGVELTDGRHHHIDQLGDG-TCSLLITGLDRADAGCYTCQVSN 4975
Score = 35.1 bits (77), Expect = 2.8
Identities = 24/101 (23%), Positives = 44/101 (43%), Gaps = 2/101 (1%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTI-KLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E T + + P + +++ V + K +V P P + W+++ + ++ S I
Sbjct: 5251 ESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMT 5310
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
L I +V E DSG Y SN+ G + AR+ +
Sbjct: 5311 DKKILHTLEIISVTRE-DSGQYAAYISNAMGAAYSSARLLV 5350
Score = 34.7 bits (76), Expect = 3.7
Identities = 14/47 (29%), Positives = 22/47 (46%)
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
T +P L+N + + C+ G P P V W++DGK L+
Sbjct: 5121 TSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLE 5167
Score = 34.3 bits (75), Expect = 4.9
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 5/95 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+F E L+ +GST +C++ P + W + ++ + + A LV
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCELSE-PTATVVWSKGGLQLQANGRREPRLQGCT-AELV 3947
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++++ ED G +TC + A+S T + AP+
Sbjct: 3948 LQDLQREDTGEYTCTCGSQ---ATSATLTVTAAPV 3979
Score = 33.5 bits (73), Expect = 8.5
Identities = 34/172 (19%), Positives = 64/172 (37%), Gaps = 4/172 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VGD + + +P V W +N ++ I+ + + I + +
Sbjct: 433 RVGDTAMFCVEL-AVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVA 491
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLD-DGGLELTKYAI 1703
A + ++ V+ P PV+ + SV + W PP + + + Y +
Sbjct: 492 FMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARME-SSVILSWSPPPHGERPVTIDGYLV 550
Query: 1704 EKHEPDNNRWIKVADVD-RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE 1754
EK + WI+ + + + + E + FRV A N G S LE
Sbjct: 551 EKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLE 602
Score = 33.5 bits (73), Expect = 8.5
Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+T C+V P+ ++TW++ + S +M LV+++V DAG ++C
Sbjct: 1181 GTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGCT-RRLVVQQVGKADAGEYSC 1238
Query: 584 VA 585
A
Sbjct: 1239 EA 1240
Score = 33.5 bits (73), Expect = 8.5
Identities = 21/92 (22%), Positives = 40/92 (43%), Gaps = 3/92 (3%)
Query: 1781 NESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKX-XXXXXXXXARIQKLSINTTYQFR 1838
+ +V ++W +GG + Y+VE+K+ +W+ + L+ TY+FR
Sbjct: 4536 SHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFR 4595
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTP-PSQP 1869
+ A +G P + + + P P QP
Sbjct: 4596 VAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQP 4627
>AL359510-13|CAI15072.1| 6620|Homo sapiens obscurin, cytoskeletal
calmodulin and titin-interacting RhoGEF protein.
Length = 6620
Score = 192 bits (467), Expect = 2e-47
Identities = 166/673 (24%), Positives = 287/673 (42%), Gaps = 42/673 (6%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
++ +P F++ + + EG+ +L C L + + W KG E + D + + +
Sbjct: 3445 VKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP--VEWR-KGPENLRDGDRYILRQEGT 3501
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y V A+L I P + IE +K+ R+
Sbjct: 3502 R--CE-LQICGLAMADAGEYLCVCGQERTSATLTI-------RALPARFIEDVKNQEARE 3551
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTL 805
G + +L ++ N + W K ++ ++ + DG + I + + D G Y+
Sbjct: 3552 GATAVLQCEL--NSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQI-RGLAMADTGEYSC 3608
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
G TSA++TV A P F + E T V R + + +
Sbjct: 3609 VC----GQERTSAMLTVR------ALPIKFTEGLRNEEATEGATA--VLRCELSKMAPVE 3656
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W++ +E + + + DG EL I + +E D+G+Y C+ GK A +T+
Sbjct: 3657 WWKGHETLRDGDRHSLRQDGARCELQIRGLVAE-DAGEYLCMC----GKERTSAMLTVRA 3711
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
F++ L+ E EG T L C+ S +W + + D + Q+G
Sbjct: 3712 MPSKFIEGLRNE-EATEGDTATLWCELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQ 3770
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G C+ + TS L V+ FI +++ E +E A+L+ E+ S+ A
Sbjct: 3771 IRGLAVVDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCEL-SKAA 3829
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W + E ++ ++Y + G +L I SV D GEYSC+ E +A +TV
Sbjct: 3830 PVEWRKGSETLRGG-DRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAP 3888
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P LQ+ + +G+ AT + EL++ A V W K G ++Q + + + G +L +
Sbjct: 3889 QPVFREPLQSLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVL 3948
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D +D GEY+C G+ +A LTV + F LR + V A+L E+
Sbjct: 3949 QDLQREDTGEYTCTCGSQATSATLTVTAAPVRF-LRELQHQEVDEGGTAHLCCELSRAGA 4007
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-- 1283
V W K + K+ ++ D L++R ++D +YTC +S L V V
Sbjct: 4008 SVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRVPR 4067
Query: 1284 VEFPPKIVDYERE 1296
+F ++ E+E
Sbjct: 4068 PKFKTRLQSLEQE 4080
Score = 189 bits (461), Expect = 8e-47
Identities = 271/1259 (21%), Positives = 487/1259 (38%), Gaps = 118/1259 (9%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F L+ T + V EC++ P + W + ++ + + + + R
Sbjct: 2168 FSRPLQDVVTTEKEKVTLECELSR-PNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYR 2226
Query: 572 EVFPEDAGTFTCVAKNAAGFAS-----STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
F D G + C A +A AS T LI L++ E+
Sbjct: 2227 CEFA-DQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLR- 2284
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
++ +P T + + + E +LEC+ V+ + W +E+ P + +
Sbjct: 2285 --VKELPVTLVRPLRDKIAMEKHRGVLECQ-VSRASAQVRWFKGSQELQPGPKYELVSDG 2341
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+Y ++ I++V E TYT A + + A + E++ ++ L+ + V
Sbjct: 2342 ---LYRKLI-ISDVHAEDEDTYTCDAGDVKTSAQFFV-------EEQSITIVRGLQDVTV 2390
Query: 747 RQGESVILSAQV-VGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGV 802
+ + + + RP W ++A + + +G H + + + V
Sbjct: 2391 MEPAPAWFECETSIPSVRPP-KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPV 2449
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ + G + +SA + V + P + + T +E ++ L P
Sbjct: 2450 HF-----TVGKSRSSARLVVSDI------PVVLTRPLEPKTGRELQSVVLSCDFRPAP-K 2497
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
++ WY+++ +SPSE + +G+ EL I + D+G Y+C AG + VT
Sbjct: 2498 AVQWYKDDTPLSPSEKFKMSLEGQMAELRILRL-MPADAGVYRC----QAGSAHSSTEVT 2552
Query: 923 IDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRX 981
++ +VT LQ + TEEG C+ SH +W N + EI +GR
Sbjct: 2553 VEAREVTVTGPLQDAEATEEG-WASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRR 2611
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
D G+++ TS L V+ F++ L D +E+ L+ E++
Sbjct: 2612 HTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVS 2671
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
A VVW +DG + P +KYDF R L + + S D G Y+C + E A V
Sbjct: 2672 DPEAHVVWRKDGVQLGPS-DKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVR 2730
Query: 1102 VVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGK 1159
V +L I RL+ +V +G +FE L+ A W G + S+ Q T G+
Sbjct: 2731 VHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGR 2790
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVE 1219
K L + + DAGE V A L V E L + + P D L E
Sbjct: 2791 KYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGE-DVELRCE 2849
Query: 1220 IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
+ V W K + I ++K+ ++ + L+IR + D EYTC + +KST L
Sbjct: 2850 LSRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASL 2909
Query: 1280 KVEVVE--FPPKIVDYEREYRIKRGSDV-TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
VE F ++ + + E ++G+ V T ++ P W ++ +P
Sbjct: 2910 HVEEKANCFTEELTNLQVE---EKGTAVFTCKTEH---PAATVTWRKGLLELRASGKHQP 2963
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS 1396
S + + LTI +E D+ Y + G A + + + + +I+E D
Sbjct: 2964 SQEGLTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGR-----RVHIIE-DLED 3013
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
+++ G+S + + W K T + N + +
Sbjct: 3014 VDV------QEGSSATFRCRISPANYEPVHWFLDK--TPLHANELNEIDAQPGGYHVLTL 3065
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTV-EKP------LKNITTEPNEDIELTCIFGGVP 1509
++ + D+ T Y++ + + V EKP L + T ED+ L C
Sbjct: 3066 RQLALKDSG--TIYFEAGDQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCETSTCD 3123
Query: 1510 QPKVTWYRDGKKLKTA---KATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV 1565
P V W +DGK L+ + + ++E +R YKC A G +S +V
Sbjct: 3124 IP-VCWTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIV 3178
Query: 1566 GIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
+ +PV E +K + G + V+ + P V W N L +Y++ +
Sbjct: 3179 RVHARPVRF--QEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQE 3235
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ ++ L+ S +Y S + G + TL V P++ G + +E +
Sbjct: 3236 GAMLELVVRNLRPQDSGRY----SCSFGDQTTSATLTVTALPAQFIGKLRNKEAT----- 3286
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
+G + + K P W K ++ RD + YC+++ CE R +A
Sbjct: 3287 --------EGATATLRCELSKAAPVE--WRKGSETLRDGDRYCLRQDGAMCELQIRGLA 3335
Score = 180 bits (437), Expect = 7e-44
Identities = 169/669 (25%), Positives = 275/669 (41%), Gaps = 39/669 (5%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVIL 754
L I+ ++K TYT + A L + + +IE L+ + V++G S
Sbjct: 2972 LTISALEKADSDTYTCDIGQAQSRAQLLV-------QGRRVHIIEDLEDVDVQEGSSATF 3024
Query: 755 SAQVVGNPRPTITWCKNNKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENS 810
++ + W + P+ A G H +T L+ +KD G +A
Sbjct: 3025 RCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLT-LRQLALKDSGTIYFEA--- 3080
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G SA + V E +P +F + T+ E + LV + +P + W ++
Sbjct: 3081 -GDQRASAALRVTE------KPSVFSRELTDATITEGEDLTLVCETSTCDIP-VCWTKDG 3132
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
+ + S + +G +L+IT + DSG YKC A + S V + V F
Sbjct: 3133 KTLRGSARCQLSHEGHRAQLLITGATLQ-DSGRYKCEAGGACSSSI----VRVHARPVRF 3187
Query: 931 VKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ L K E EG L C S + KW + + D + QEG
Sbjct: 3188 QEAL-KDLEVLEGGAATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNL 3246
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVW 1049
D G C DQ TS L V +FI KL++ E E A L E+ S+ A V W
Sbjct: 3247 RPQDSGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCEL-SKAAPVEW 3305
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEI 1109
+ E ++ ++Y + G + +L IR ++ D EYSC+ +E +A +T+ +P
Sbjct: 3306 RKGSETLRDG-DRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHF 3364
Query: 1110 ITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
I RL++Q+ +G AT EL+K A V W K ++ + L DG +L+I
Sbjct: 3365 IGRLRHQESIEGATATLRCELSKA-APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423
Query: 1170 LDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+ DAGEYSC G + +A LTV+ FT L V T A L E+ + V W
Sbjct: 3424 VADAGEYSCVCGEERTSATLTVKALPAKFTEGLRNEEAVEGAT-AMLWCEL-SKVAPVEW 3481
Query: 1230 YKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPK 1289
K + D +++ L + + L I D EY CV +++ L + + P +
Sbjct: 3482 RKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRAL--PAR 3539
Query: 1290 IVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKK 1349
++ + + G+ L + + EW S+ ++ D L I+
Sbjct: 3540 FIEDVKNQEAREGATAVLQCELNSAAPV--EWRKGSETLRDGDRYSLRQDGTKCELQIRG 3597
Query: 1350 VENTDAGIY 1358
+ D G Y
Sbjct: 3598 LAMADTGEY 3606
Score = 170 bits (414), Expect = 4e-41
Identities = 196/889 (22%), Positives = 349/889 (39%), Gaps = 58/889 (6%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLV-AIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ +P F + K Q EG+ +L+C L A P + W E + + S+ +
Sbjct: 3797 VRALPARFIEDVKNQEAREGATAVLQCELSKAAP---VEWRKGSETLRGGDRYSLRQDGT 3853
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
C L+I + G Y+ V A+L + P EPL+S+
Sbjct: 3854 R---CE-LQIHGLSVADTGEYSCVCGQERTSATLTV-------RAPQPVFREPLQSLQAE 3902
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYT 804
+G + L ++ P T+ W K ++A + G T + +L+ + +D G YT
Sbjct: 3903 EGSTATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGCTAEL-VLQDLQREDTGEYT 3960
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P F+ Q V E GT L ++R S+
Sbjct: 3961 CTC----GSQATSATLTV------TAAPVRFLRELQHQEVDEGGTAHLCCELSRAGA-SV 4009
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + + + P DG EL++ V+ E D+GDY C G + A +++
Sbjct: 4010 EWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQE-DAGDYTC----DTGHTQSMASLSVR 4064
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHTVS---TKWYHNKKEISGMDHREIIQEGRX 981
V + F LQ S E E G L CQ S S +W E+ E+ +G
Sbjct: 4065 VPRPKFKTRLQ-SLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGAT 4123
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
D G C+ Q+T+ L V E +R L D EV + E++
Sbjct: 4124 RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVS 4183
Query: 1042 SETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
A V W G ++ + + G I L ++ + D G S L + + +A++
Sbjct: 4184 RAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQL 4243
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTID-G 1158
TV I+ LQ+ ++++G A+F+ L++ RW G +Q + +T++ G
Sbjct: 4244 TVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQG 4303
Query: 1159 KKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
L ++ L+DAG S VG C++ ++ + N +R E + +A
Sbjct: 4304 TLHLLTLHKVTLEDAGTVSFHVGT--CSSEAQLKVTAKNTVVRGLENVEALEGGEALFEC 4361
Query: 1219 EIPD-ETLDVTWYKKKSVIEDTEKFTLI--SDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
++ E TW + +E ++ + + L+++ D C T + D +
Sbjct: 4362 QLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGDMVT 4421
Query: 1276 TTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHT 1334
+ L V +I++ + ++ G+ +A P W +N ++
Sbjct: 4422 SAFLTVRGWRL--EILEPLKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSD 4479
Query: 1335 -KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEID 1393
+ D +L ++ + AG + C A +T+L P PP ++
Sbjct: 4480 WTVTADGSHHALLLRSAQPHHAG----EVTFACRDAVASARLTVLGLPDPPEDAEVVARS 4535
Query: 1394 SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFR 1452
S ++ + W P + G + Y VE +E T +W + + + + + L +YRFR
Sbjct: 4536 SHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFR 4595
Query: 1453 AYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIEL 1501
AV V + + ++ + K P P ++ ED+ L
Sbjct: 4596 VAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-ESRQVAAGEDVSL 4643
Score = 161 bits (392), Expect = 2e-38
Identities = 179/903 (19%), Positives = 342/903 (37%), Gaps = 56/903 (6%)
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
+DEG Y+ + G + V EP A+ L + Q E G ++
Sbjct: 863 QDEGTYSCRV----GEDSVDFRLRVSEPKVVFAKEQLARRKLQA----EAGASATLSCEV 914
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
+TWY++ + +S S + G LV+ + D+G+Y C AG
Sbjct: 915 AQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQA-GQADAGEYSC----EAGGQRL 969
Query: 918 GARVTIDVEKVTFVKH--LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHRE 974
+ + KV F K + E G + L C+ + WY + K++S
Sbjct: 970 SFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQTEVMWYKDGKKLSSSLKVH 1029
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKL---QDFEVKEK 1031
+ +G D G C + Q S L + E F ++ + + +
Sbjct: 1030 VEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAG 1089
Query: 1032 DVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
A+L E+ +V W +DG+ + +K E +G R+L + D GEYSC
Sbjct: 1090 ASAMLSCEVAQAQTEVTWYKDGKKLS-SSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148
Query: 1092 RDESCTAEVTVVELPPEIITRLQN----QKVNKGNKATFEIELTKGDALVRWFKDGSEIQ 1147
+ + + + E P + + Q+ + G A E+ + V W+KDG ++
Sbjct: 1149 GGQRVSFHLHITE-PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLS 1207
Query: 1148 FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR--LPEF 1205
S+ +++ + G ++L + DAGEYSCE G + + L + EP F +
Sbjct: 1208 SSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNE 1267
Query: 1206 ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
+ A A L+ E+ +VTWYK + + K + + R L++++ + D E
Sbjct: 1268 VRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327
Query: 1266 YTCVLLDAKSTTKLKV-EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
YTC + + L V E K R+ + + G+ TL + A Q W +
Sbjct: 1328 YTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEV-AQAQTEVTWYKD 1386
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL--ENNCGHADVEMNVTILDKPS 1382
K + + + L +++ D G Y + DV + K
Sbjct: 1387 GKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQ 1446
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
P + + +S+ C E T + + + +++ + + ++ + T+ +
Sbjct: 1447 PVHREVQAQAGASTTLSC----EVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQ 1502
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
+ E S+ ++ + E K + + + E L+
Sbjct: 1503 QAGQA-------VAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLS 1555
Query: 1503 CIFGGVPQPKVTWYRDGKKL-KTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
C Q +VTWY+DGKKL ++K E Y C A G+
Sbjct: 1556 CEVAQA-QTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKA----GD 1610
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDK 1617
S + + + V+ + ++ + T E EV WYK+G KL +
Sbjct: 1611 QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS 1670
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASN---TAGTSSVEVTLKVYDKPSKPEGPVI 1674
+ + T + +++ ++ + +Y+ EA + E+ ++ ++P + E P++
Sbjct: 1671 KVRVEAVGCTRRLVVQQAGQAEAGEYSCEAGGQQLSFRLQVAELEPQISERPCRRE-PLV 1729
Query: 1675 MRE 1677
++E
Sbjct: 1730 VKE 1732
Score = 161 bits (392), Expect = 2e-38
Identities = 200/904 (22%), Positives = 364/904 (40%), Gaps = 67/904 (7%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ +P F++ + + EG+ +L C L + + W +KG E + D + ++ D
Sbjct: 3621 VRALPIKFTEGLRNEEATEGATAVLRCELSKMAP--VEW-WKGHETLRDGDRH-SLRQD- 3675
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y + A L + P + IE L++ +
Sbjct: 3676 GARCE-LQIRGLVAEDAGEYLCMCGKERTSAMLTV-------RAMPSKFIEGLRNEEATE 3727
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKA 807
G++ L ++ + + W K ++ ++ DGD HS+ + +++ G+ + A
Sbjct: 3728 GDTATLWCEL--SKAAPVEWRKGHETLR------DGDRHSLRQDGSRCELQIRGLAVVDA 3779
Query: 808 ENSE---GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P FI + +E T L +++ +
Sbjct: 3780 GEYSCVCGQERTSATLTVR------ALPARFIEDVKNQEAREGATAVLQCELSK--AAPV 3831
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + +E + + + DG EL I + S D+G+Y CV G+ A +T+
Sbjct: 3832 EWRKGSETLRGGDRYSLRQDGTRCELQIHGL-SVADTGEYSCVC----GQERTSATLTVR 3886
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXX 983
+ F + LQ S + EEG T L+C+ S T + W ++ RE +G
Sbjct: 3887 APQPVFREPLQ-SLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAE 3945
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G C Q TS L V F+R+LQ EV E A L E++
Sbjct: 3946 LVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCCELSRA 4005
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
A V W + + P KY + G +L +R D G+Y+C A ++V
Sbjct: 4006 GASVEWRKGSLQLFPCA-KYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVR 4064
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
P+ TRLQ+ + G+ A +L+ + A+V+W K+G E+ ++ G +
Sbjct: 4065 VPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATR 4124
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP 1221
+L I+ + D GEY+C G K A L V EP + L + V A+ D + E+
Sbjct: 4125 ELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVD-AEVTADEDVEFSCEVS 4183
Query: 1222 DE-TLDVTWYKKKSVIEDTEKFTL-ISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
V W + ++ E + + D + TL ++ T +D + L + S+ +L
Sbjct: 4184 RAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQL 4243
Query: 1280 KVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
V E I++ ++ ++ G D + W + ++ + +++
Sbjct: 4244 TVRAPEV--TILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVE 4301
Query: 1340 SKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI--LEIDSSS 1396
+ LT+ KV DAG + C ++ ++ VT G N+ LE +
Sbjct: 4302 QGTLHLLTLHKVTLEDAGTVSFHV-GTCS-SEAQLKVT-AKNTVVRGLENVEALEGGEAL 4358
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
+PE ++ ++ + + E + +N + ++NL+ S R A
Sbjct: 4359 FECQLSQPEVAAHTWLLDDEPVHTS-ENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAG 4417
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG-GVPQPKVTW 1515
+ V T + ++ +++ + +PLKN TC VP + +W
Sbjct: 4418 DMV--------TSAFLTVRGWRLE---ILEPLKNAAVRAGAQACFTCTLSEAVPVGEASW 4466
Query: 1516 YRDG 1519
Y +G
Sbjct: 4467 YING 4470
Score = 161 bits (390), Expect = 3e-38
Identities = 157/735 (21%), Positives = 292/735 (39%), Gaps = 46/735 (6%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ G+ +L C VA + ++ W G+++ + + ++ L + K
Sbjct: 1087 EAGASAMLSCE-VAQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRR----LVLPQAGKADA 1141
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G Y+ A + L I KE Q + + G + +LS +V P+
Sbjct: 1142 GEYSCEAGGQRVSFHLHITEPKGVFAKE--QSVH--NEVQAEAGTTAMLSCEVA-QPQTE 1196
Query: 766 ITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+TW K+ K + + + + G T + + + K D G Y+ +A G S + +
Sbjct: 1197 VTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA-DAGEYSCEA----GGQRVSFQLHI 1251
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
EP A+ L N E+ + + L V + +TWY++ + +S S +
Sbjct: 1252 TEPKAVFAKEQLVHN---EVRTEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRIE 1307
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH--LQKSYET 940
G +LV+ + D+G+Y C AG + + K F K + +
Sbjct: 1308 AAGCMRQLVVQQA-GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA 1362
Query: 941 EEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
E G L C+ + WY + K++S + G D G C
Sbjct: 1363 EAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSC 1422
Query: 1000 IVKDQETSTMLVVKETIPEFIRKL---QDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
Q S L V E F ++ ++ + + L E+ +V+W +DG+ +
Sbjct: 1423 EAGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL 1482
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQ-- 1114
+K E G R+L ++ GEYSC + + + V E P + + Q
Sbjct: 1483 S-FSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAE-PKAVFAKEQPA 1540
Query: 1115 --NQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+ G AT E+ + V W+KDG ++ S+ +++ G ++L + + D
Sbjct: 1541 SREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQAD 1600
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEF--ILVPANTDAYLTVEIPDETLDVTWY 1230
AGEYSC+ G+ + + L V EP + F P + A A L+ E+ +VTWY
Sbjct: 1601 AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWY 1660
Query: 1231 KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
K + + K + + R L++++ + + EY+C +++V E P+I
Sbjct: 1661 KDGKKLSSSSKVRVEAVGCTRRLVVQQAGQAEAGEYSCEA--GGQQLSFRLQVAELEPQI 1718
Query: 1291 VD--YERE-YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
+ RE +K D+ L W+ + I++ K + + + +LT+
Sbjct: 1719 SERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTV 1778
Query: 1348 KKVENTDAGIYKLRL 1362
+ D+ IY R+
Sbjct: 1779 HGAQVLDSAIYSCRV 1793
Score = 152 bits (369), Expect = 1e-35
Identities = 142/641 (22%), Positives = 260/641 (40%), Gaps = 32/641 (4%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ G+ L C VA + ++ W G+++ + V L + + +
Sbjct: 1639 EAGASATLSCE-VAQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRR----LVVQQAGQAEA 1693
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G Y+ A ++ L + +++ E P EPL +V++ E +IL+A + T
Sbjct: 1694 GEYSCEAGGQQLSFRLQVA-ELEPQISERPCRREPL---VVKEHEDIILTATLATPSAAT 1749
Query: 766 ITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+TW K+ + K T S GDTH++T+ +V D +Y+ + +EG + V
Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTV-HGAQVLDSAIYSCRV-GAEG---QDFPVQV 1804
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
EE + F + + + GT+ L ++ + W N + +
Sbjct: 1805 EEVAAK------FCRLLEPVCGELGGTVTLACELSP-ACAEVVWRCGNTQLRVGKRFQMV 1857
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
+G L + + +E D+G+Y C + + A++T+ V +V + EE
Sbjct: 1858 AEGPVRSLTVLGLRAE-DAGEYVCESRDD----HTSAQLTVSVPRVVKFMSGLSTVVAEE 1912
Query: 943 GKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
G +C S + V+ W+ + + + I Q G D G I
Sbjct: 1913 GGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEA 1972
Query: 1002 KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKN 1061
+ +S L V+E F +KL+ V+E+ LEVE+ ++ W R+ + P KN
Sbjct: 1973 EGASSSAALRVREAPVLFKKKLEPQTVEERSSVTLEVELTRPWPELRWTRNATALAPGKN 2032
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKG 1121
+ G +L + N D G + C D+ A++TV ++ LQ + +
Sbjct: 2033 -VEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQ 2091
Query: 1122 NKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG 1181
AT E++L+ D W +DG Q L + G L + +D+G +
Sbjct: 2092 GTATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAE 2151
Query: 1182 NSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEK 1241
+A L V E ++F+ L + ++ L E+ +DV W K + +
Sbjct: 2152 GVHTSARLVVTELPVSFSRPLQD-VVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKT 2210
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
+ + R+L I +C DQ Y C DA+S+ +KV+
Sbjct: 2211 MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQ 2251
Score = 138 bits (334), Expect = 2e-31
Identities = 135/567 (23%), Positives = 235/567 (41%), Gaps = 35/567 (6%)
Query: 632 IPPTFSKKP---KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ P S++P + V E DI+L L + WL G EI + A + D
Sbjct: 1714 LEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDT 1773
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
H L + + Y+ V EG+ P+ +++ + +++EP+ +
Sbjct: 1774 H----TLTVHGAQVLDSAIYSC-RVGAEGQ-DFPV--QVEEVAAKFCRLLEPVCGEL--- 1822
Query: 749 GESVILSAQVVGNPRPTITWCKNN--KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G +V L+ ++ + C N + K ++G S+T+L + +D G Y +
Sbjct: 1823 GGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLG-LRAEDAGEYVCE 1881
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
+ + TSA +TV P F++ + +E G V+ + V ++ W
Sbjct: 1882 SRDDH----TSAQLTVSVPRVVK-----FMSGLSTVVAEEGGEATFQCVVSPSDV-AVVW 1931
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+R+ ++ PSE + G + L I+++ E D+G + + G SS A + +
Sbjct: 1932 FRDGALLQPSEKFAISQSGASHSLTISDLVLE-DAGQ---ITVEAEGASSSAA-LRVREA 1986
Query: 927 KVTFVKHLQKSYETEEGKTVILECQ-TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
V F K L+ EE +V LE + T +W N ++ + EI EG
Sbjct: 1987 PVLFKKKLEPQ-TVEERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLV 2045
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G C D +T L V+ +R LQ E +E+ A +EV+++
Sbjct: 2046 LHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADV 2105
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
D W RDG + + RG + L + D G +A + V EL
Sbjct: 2106 DGSWTRDGLRFQQGPTCH-LAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTEL 2164
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P LQ+ + K T E EL++ + VRW KDG E++ + + G + L I
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTI 2224
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVE 1192
Y C+ D G Y C+ +++ +A + V+
Sbjct: 2225 YRCEFADQGVYVCDAHDAQSSASVKVQ 2251
Score = 134 bits (325), Expect = 2e-30
Identities = 164/758 (21%), Positives = 285/758 (37%), Gaps = 49/758 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P F K +E + L+C V+ PE + W G ++ P + +
Sbjct: 2646 PVVFLKALDDLSAEERGTLALQCE-VSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRG-- 2702
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L + +V G YT + E A + V + G + + LK+M V +GES
Sbjct: 2703 --LVVHDVSPEDAGLYTCHVGSEETRARVR-VHDLHVG------ITKRLKTMEVLEGESC 2753
Query: 753 ----ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
+LS + +P K G + I +++ D G
Sbjct: 2754 SFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKY-ILVVREAAPSDAGEVVFSVR 2812
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
G+ +++I E P I ++ V ++L ++R P + W +
Sbjct: 2813 ---GLTSKASLIVRERPAA-------IIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLK 2861
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
+ + I S+ +G LVI + D+G+Y C A KS+ A + ++ +
Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLK-DAGEYTCEVE--ASKST--ASLHVEEKAN 2916
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXX 987
F + L + + EE T + C+T H +T W E+ + QEG
Sbjct: 2917 CFTEELT-NLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADV 1047
D C + ++ L+V+ I L+D +V+E A I+ +
Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEP 3035
Query: 1048 V-WERDGEIIKPKK-NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W D + + N+ D + G+ L +R ++ D G D+ +A + V E
Sbjct: 3036 VHWFLDKTPLHANELNEIDAQPGGY-HVLTLRQLALKDSGTIYFEAGDQRASAALRVTEK 3094
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P L + + +G T E + D V W KDG ++ S QL+ +G + +L I
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSHEGHRAQLLI 3154
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
L D+G Y CE G + ++I+ V + F L + ++ A L +
Sbjct: 3155 TGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGGA-ATLRCVLSSVAA 3213
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
V W +V+ +K++L + L++R D Y+C D TT + V
Sbjct: 3214 PVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD--QTTSATLTVTA 3271
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P + + R G+ TL + +A P EW S+ ++ D
Sbjct: 3272 LPAQFIGKLRNKEATEGATATLRCELSKAAPV---EWRKGSETLRDGDRYCLRQDGAMCE 3328
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
L I+ + DA Y CG ++TI P+
Sbjct: 3329 LQIRGLAMVDAAEYSC----VCGEERTSASLTIRPMPA 3362
Score = 131 bits (316), Expect = 3e-29
Identities = 147/691 (21%), Positives = 264/691 (38%), Gaps = 38/691 (5%)
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
E GT ++ +TWY++ + +S S + G LV+ + D+G+Y
Sbjct: 1547 EAGTSATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEA-GQADAGEYS 1605
Query: 906 CVASNSAGKSSHGARVTIDVEKVTFVKH--LQKSYETEEGKTVILECQTSHT-VSTKWYH 962
C AG + + KV F K + + E G + L C+ + WY
Sbjct: 1606 C----KAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYK 1661
Query: 963 NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRK 1022
+ K++S + G + G C Q+ S L V E P+ +
Sbjct: 1662 DGKKLSSSSKVRVEAVGCTRRLVVQQAGQAEAGEYSCEAGGQQLSFRLQVAELEPQISER 1721
Query: 1023 ---LQDFEVKEKDVAILEVEINSETA-DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRN 1078
+ VKE + IL + + +A V W +DG I+ K +++ +G L +
Sbjct: 1722 PCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSK-RHETASQGDTHTLTVHG 1780
Query: 1079 TSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR 1138
V D YSC + E V V E+ + L+ G T EL+ A V
Sbjct: 1781 AQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSPACAEVV 1840
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPS-IN 1197
W ++++ Q+ +G + L + +DAGEY CE + +A LTV P +
Sbjct: 1841 WRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVK 1900
Query: 1198 FTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRK 1257
F L + + V P + + V W++ ++++ +EKF + +L I
Sbjct: 1901 FMSGLSTVVAEEGGEATFQCVVSPSD-VAVVWFRDGALLQPSEKFAISQSGASHSLTISD 1959
Query: 1258 CTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQP 1317
+D + T A S+ L+V E P ++ S VTL V+ P P
Sbjct: 1960 LVLEDAGQITVEAEGASSSAALRVR--EAPVLFKKKLEPQTVEERSSVTLEVELTR-PWP 2016
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
W N+ + K+ + + L + V D G + ++ A + + +
Sbjct: 2017 ELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQ 2076
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQ 1437
+ E ++++ + + G+ T + +Q+ T ++V+ T
Sbjct: 2077 VRLVRGLQAVEAREQGTATMEVQLSHADVDGSWT--RDGLRFQQGPTCH-LAVRGPMHTL 2133
Query: 1438 TSIQNLKTNSS--YRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
T + L+ S F+A V+ T V+ E + + +PL+++ T
Sbjct: 2134 T-LSGLRPEDSGLMVFKAEGVH----------TSARLVVTELPV---SFSRPLQDVVTTE 2179
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK 1526
E + L C P V W +DG +L+ K
Sbjct: 2180 KEKVTLECELSR-PNVDVRWLKDGVELRAGK 2209
Score = 126 bits (305), Expect = 7e-28
Identities = 122/542 (22%), Positives = 224/542 (41%), Gaps = 23/542 (4%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTL 805
G S LS +V + +TW K+ K + + + ++ G T + + + + D G Y+
Sbjct: 1549 GTSATLSCEVA-QAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQA-DAGEYSC 1606
Query: 806 KAENSEGIAETSAVITVEEPTEENA-EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
KA G S + V EP A E P +E+ + + L V + +
Sbjct: 1607 KA----GDQRLSFHLHVAEPKVVFAKEQPAH----REVQAEAGASATLSCEVAQAQT-EV 1657
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
TWY++ + +S S + G LV+ + ++G+Y C A + S +V
Sbjct: 1658 TWYKDGKKLSSSSKVRVEAVGCTRRLVVQQA-GQAEAGEYSCEAGGQ--QLSFRLQVAEL 1714
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXX 982
+++ ++ +E + +IL T + W + EI E +G
Sbjct: 1715 EPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTH 1774
Query: 983 XXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS 1042
D + C V + + V+E +F R L+ + L E++
Sbjct: 1775 TLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSP 1834
Query: 1043 ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
A+VVW ++ K ++ G +R L + D GEY C RD+ +A++TV
Sbjct: 1835 ACAEVVWRCGNTQLRVGK-RFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTV 1893
Query: 1103 -VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
V + ++ L +G +ATF+ ++ D V WF+DG+ +Q S ++ G
Sbjct: 1894 SVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASH 1953
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP 1221
L I D L+DAG+ + E + +A L V E + F +L E V + L VE+
Sbjct: 1954 SLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL-EPQTVEERSSVTLEVELT 2012
Query: 1222 DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
++ W + + + + + ++ + L++ D+ + C D K+ KL V
Sbjct: 2013 RPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTV 2072
Query: 1282 EV 1283
E+
Sbjct: 2073 EM 2074
Score = 122 bits (293), Expect = 2e-26
Identities = 206/1051 (19%), Positives = 385/1051 (36%), Gaps = 70/1051 (6%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
K P+ V G D + C +A+P + WL EE+V ++++ E H L I
Sbjct: 425 KLPRKTAVRVG-DTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRH----TLTI 479
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVRQGESVILSA 756
+ G +A G+ + K P Q ++P+ R SVILS
Sbjct: 480 SQCCLEDVGQVAFMA----GDCQTSTQFCVSAPRKPPLQPPVDPVVK--ARMESSVILSW 533
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT-ILKPK----KVKDEGVYTLKAENSE 811
+ +T K L T + H + P+ V +EG + +
Sbjct: 534 SPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALN 593
Query: 812 GIAETSAVITVEEPTEENAEPPLFINR-FQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
++ + E P + P L + + + E G + +T + W+ +
Sbjct: 594 SFGQSPYL---EFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLT--VASAGEWFLDG 648
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN--SAGKSSHGARVTIDVEKV 928
+ + S + D L I V + + K VA+ S+ + A + K
Sbjct: 649 QALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKP 708
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ E ++ E + + W + + +S E+
Sbjct: 709 PAAAAREVLARLHEEAQLLAEL-SDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRD 767
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQD---FEVKEKDVAILEVEINSETA 1045
D G+ +C+ + + L V + + F+ K + A E E +
Sbjct: 768 VARDDAGLYECVSRGGRIAYQLSV-QGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHV 826
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W +DG + ++ E G +L + DEG YSC + ++S + V E
Sbjct: 827 HVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSE- 885
Query: 1106 PPEII---TRLQNQKVNK--GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKK 1160
P+++ +L +K+ G AT E+ + V W+KDG ++ S+ + + G
Sbjct: 886 -PKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944
Query: 1161 QKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR--LPEFILVPANTDAYLTV 1218
++L + DAGEYSCE G + + L V+EP + F + A A L+
Sbjct: 945 RRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSC 1004
Query: 1219 EIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK 1278
E+ +V WYK + + K + + +R L++++ + D +Y+C + + +
Sbjct: 1005 EVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFR 1064
Query: 1279 LKV-EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
L + E K E + + G+ L + A Q W + K +
Sbjct: 1065 LHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGME 1123
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
+ + L + + DAG Y G V ++ I + P G + + S
Sbjct: 1124 VKGCTRRLVLPQAGKADAGEYSC----EAGGQRVSFHLHITE---PKG---VFAKEQSVH 1173
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVN 1457
N + G + ++ V + + T + K ++ + +K + R V
Sbjct: 1174 N---EVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVK-GCTRRLVVQQVG 1229
Query: 1458 EVDISDASETTEYYKVIKETKIQSPTV----EKPLKN-ITTEPNEDIELTCIFGGVPQPK 1512
+ D + S +V + I P E+ + N + TE L+C Q +
Sbjct: 1230 KADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQA-QTE 1288
Query: 1513 VTWYRDGKKL-KTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
VTWY+DGKKL ++K E Y C A G S + +
Sbjct: 1289 VTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEA----GGQRLSFHLDVS 1344
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+ + + +K + + T E EV WYK+G KL + + + T
Sbjct: 1345 EPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCT 1404
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
+ +++ ++ + +Y+ EA + S++V
Sbjct: 1405 RRLVVQQACQADTGEYSCEAGGQRLSFSLDV 1435
Score = 122 bits (293), Expect = 2e-26
Identities = 150/720 (20%), Positives = 283/720 (39%), Gaps = 38/720 (5%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSV-LKITNVKKFQ 704
+ G+ L C VA + ++ W G+++ + V +E+ + C+ L + +
Sbjct: 1547 EAGTSATLSCE-VAQAQTEVTWYKDGKKL--SSSSKVRMEA---VGCTRRLVVQEAGQAD 1600
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G Y+ A ++ L + KE P E + G S LS +V +
Sbjct: 1601 AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEVA-QAQT 1655
Query: 765 TITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
+TW K+ K + + + ++ G T + + + + + G Y+ +A G + S +
Sbjct: 1656 EVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQA-EAGEYSCEA----GGQQLSFRLQ 1710
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
V E + +E P R + + VKE I L A + ++TW ++ I S+
Sbjct: 1711 VAELEPQISERPC---RREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHET 1767
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE 941
G+ L + +DS Y C G V ++ F + L+ E
Sbjct: 1768 ASQGDTHTLTVHGAQV-LDSAIYSC----RVGAEGQDFPVQVEEVAAKFCRLLEPVCG-E 1821
Query: 942 EGKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
G TV L C+ S + W ++ +++ EG D G C
Sbjct: 1822 LGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCE 1881
Query: 1001 VKDQETSTMLVVK-ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPK 1059
+D TS L V + +F+ L +E A + ++ VVW RDG +++P
Sbjct: 1882 SRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPS 1941
Query: 1060 KNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVN 1119
+ K+ + G L I + + D G+ + S +A + V E P +L+ Q V
Sbjct: 1942 E-KFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVE 2000
Query: 1120 KGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE 1179
+ + T E+ELT+ +RW ++ + + ++++ +G + +L +++ D G + CE
Sbjct: 2001 ERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCE 2060
Query: 1180 VGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDT 1239
+ K A LTVE + L + + A + V++ +D +W + +
Sbjct: 2061 TPDDKTQAKLTVEMRQVRLVRGL-QAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQQG 2119
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKST-TKLKVEVVEFPPKIVDYEREYR 1298
L TL + +D ++ A+ T ++ V E P ++
Sbjct: 2120 PTCHLAVRGPMHTLTLSGLRPEDS---GLMVFKAEGVHTSARLVVTELPVSFSRPLQDVV 2176
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
VTL + P + W+ + ++ K + SLTI + E D G+Y
Sbjct: 2177 TTEKEKVTLECELSR-PNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVY 2235
Score = 115 bits (277), Expect = 2e-24
Identities = 136/655 (20%), Positives = 244/655 (37%), Gaps = 46/655 (7%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSIT 790
P PL+ ++ + E V L ++ P + W K+ ++A T + G S+T
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLECEL-SRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLT 2223
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAV----------ITVEEPTE-----ENAE---- 831
I + + D+GVY A +++ A + E+ E ENAE
Sbjct: 2224 IYRCE-FADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQ 2282
Query: 832 ------PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
P + ++ EK L +V+R + W++ ++ + P DG
Sbjct: 2283 LRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASA-QVRWFKGSQELQPGPKYELVSDG 2341
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+L+I++V +E D Y C AG A+ ++ + +T V+ LQ E
Sbjct: 2342 LYRKLIISDVHAE-DEDTYTC----DAGDVKTSAQFFVEEQSITIVRGLQ-DVTVMEPAP 2395
Query: 946 VILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
EC+TS KW K + + + QEG G + V
Sbjct: 2396 AWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGK 2455
Query: 1004 QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY 1063
+S LVV + R L+ +E +L + V W +D + P + K+
Sbjct: 2456 SRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQWYKDDTPLSPSE-KF 2514
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
G + +L I D G Y C + EVTV + LQ+ + +
Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEEGW 2574
Query: 1124 ATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
A+F EL+ D V W +G + + +++ G++ L + DAG
Sbjct: 2575 ASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKV 2634
Query: 1184 KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFT 1243
+A L V + F L + T A L E+ D V W K + ++K+
Sbjct: 2635 STSARLEVRVKPVVFLKALDDLSAEERGTLA-LQCEVSDPEAHVVWRKDGVQLGPSDKYD 2693
Query: 1244 LISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGS 1303
+ R L++ + +D YTC + T+ +V V + I + + G
Sbjct: 2694 FLHTAGTRGLVVHDVSPEDAGLYTCHV--GSEETRARVRVHDLHVGITKRLKTMEVLEGE 2751
Query: 1304 DVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAG 1356
+ ++ +++ P W V K + + + + L +++ +DAG
Sbjct: 2752 SCSFECVLSHESASDP-AMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAG 2805
Score = 105 bits (253), Expect = 1e-21
Identities = 83/355 (23%), Positives = 147/355 (41%), Gaps = 38/355 (10%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P+ AP+F+ +L+ + DG V F+C V G P P + WF+ +++ + +
Sbjct: 5117 PSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINE 5176
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDH--GSEMTVXXXXX 618
D L+I V P D G + C+A+N+ G +S+ EL V+ +D+ ++ T
Sbjct: 5177 DQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYF 5236
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL---------ECRLVAIPEPDIAWLF 669
+ EG T + Q V+E D+ + + ++ P P + W
Sbjct: 5237 SAQGYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFK 5296
Query: 670 KGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT 729
G+ + +I + + +H L+I +V + G Y N G A L ++
Sbjct: 5297 DGQPLTASAHIRMTDKKILH----TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRG 5352
Query: 730 GEKE-------------PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
++ PP+++E V++G S+ S +V G P PT+ W +
Sbjct: 5353 PDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERG 5412
Query: 777 AL---------PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
L S HS+ +L + + +G YT A N+ G A SA + V
Sbjct: 5413 VLWIGPDTPGYTVASSAQQHSLVLLDVGR-QHQGTYTCIASNAAGQALCSASLHV 5466
Score = 104 bits (250), Expect = 3e-21
Identities = 162/749 (21%), Positives = 289/749 (38%), Gaps = 66/749 (8%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+EG + +C +V+ + + W G + P E +++ H L I+++
Sbjct: 1911 EEGGEATFQC-VVSPSDVAVVWFRDGALLQPSEKFAISQSGASHS----LTISDLVLEDA 1965
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G TV A EG AS L+++ + P + L+ V + SV L ++ P P
Sbjct: 1966 GQITVEA---EG-ASSSAALRVR---EAPVLFKKKLEPQTVEERSSVTLEVELT-RPWPE 2017
Query: 766 ITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+ W +N P K + ++G H + +L D G + + + + T A +TV
Sbjct: 2018 LRWTRNATALAPGKNVEIHAEGARHRL-VLHNVGFADRGFFGCETPDDK----TQAKLTV 2072
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E + Q + +E+GT + +++ V +W R+ T
Sbjct: 2073 E------MRQVRLVRGLQAVEAREQGTATMEVQLSHADVDG-SWTRDGLRFQQGPTCHLA 2125
Query: 883 FDGENIELVITNVDSEIDSG-----------DYKCVASNSAGKSSHGAR--VTIDVEKVT 929
G L ++ + E DSG + V + S + VT + EKVT
Sbjct: 2126 VRGPMHTLTLSGLRPE-DSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVT 2184
Query: 930 F----------VKHLQKSYETEEGKTVILECQ---TSHTVSTKWYHNKKEI-----SGMD 971
V+ L+ E GKT+ + Q S T+ + ++
Sbjct: 2185 LECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQS 2244
Query: 972 HREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+ +GR D G I+ + ++ E+ L VKE +R L+D EK
Sbjct: 2245 SASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEK 2304
Query: 1032 DVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
+LE +++ +A V W + + ++P KY+ G RKL I + DE Y+C
Sbjct: 2305 HRGVLECQVSRASAQVRWFKGSQELQPGP-KYELVSDGLYRKLIISDVHAEDEDTYTCDA 2363
Query: 1092 RDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSN 1150
D +A+ V E I+ LQ+ V + A FE E + +W + +Q
Sbjct: 2364 GDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGG 2423
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPA 1210
++ L +G +L + G VG S+ +A L V + + T L E
Sbjct: 2424 NVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPL-EPKTGRE 2482
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
L+ + V WYK + + +EKF + + + L I + D Y C
Sbjct: 2483 LQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 2542
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
A S+T++ VE E + E + + + + ++ EW +N +
Sbjct: 2543 GSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYN 2599
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
+ S + +L +K ++ DAGI +
Sbjct: 2600 DSFHEISHKGRRHTLVLKSIQRADAGIVR 2628
Score = 98.3 bits (234), Expect = 3e-19
Identities = 119/564 (21%), Positives = 219/564 (38%), Gaps = 39/564 (6%)
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVK 798
++ V +G+ LS V G P+P W K+ + V + D + + + K
Sbjct: 245 RTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
D G+YT A N G +S ++ V EP A P F R Q++ V+EK + + V +
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLVVVREP----AVP--FKKRLQDLEVREKESATFLCEVPQ 358
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P W++ + S +G L + NV ++ D Y C ++ G
Sbjct: 359 -PSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSAD-DDAVYIC-------ETPEG 409
Query: 919 ARVTIDVE-KVTFVKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISGMDHREII 976
+R ++ + ++ L + G T + + + V W N++E+ I
Sbjct: 410 SRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAIS 469
Query: 977 QEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEK-DVAI 1035
EG DVG + + D +TST V ++ D VK + + ++
Sbjct: 470 AEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSV 529
Query: 1036 LEVEINSETADVVWERDGEIIKPKK-NKYDF---EKRGHIRKLYIRNTSVHDEGEYSCIL 1091
+ + DG +++ KK Y + + + + V +EG + +
Sbjct: 530 ILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRV 589
Query: 1092 RDESCTAEVTVVELP------PEIITR--LQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ + +E P P++ R L+ + +G + TF ++LT A WF DG
Sbjct: 590 SALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASA-GEWFLDG 648
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
++ S+ ++ D + L I + G V N ++I + T P
Sbjct: 649 QALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKP 708
Query: 1204 -----EFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
+L + +A L E+ D+ VTW K + K+ + + +R L++R
Sbjct: 709 PAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDV 768
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVE 1282
DD Y CV + +L V+
Sbjct: 769 ARDDAGLYECVSRGGRIAYQLSVQ 792
Score = 89.4 bits (212), Expect = 1e-16
Identities = 108/524 (20%), Positives = 208/524 (39%), Gaps = 37/524 (7%)
Query: 1139 WFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEE 1193
W KDG + + H+ + LKI C D G Y+C VG + + ++ V E
Sbjct: 271 WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVRE 330
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
P++ F RL + + V A E+P + + W+K+++ + + K+ + + +R L
Sbjct: 331 PAVPFKKRLQD-LEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRL 389
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQA 1313
+R + DD Y C + T E+ + R+ ++ G V+ A
Sbjct: 390 TVRNVSADDDAVYICETPEGSRTV---AELAVQGNLLRKLPRKTAVRVGDTAMFCVEL-A 445
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P W+ N + + S + +LTI + D G + +C +
Sbjct: 446 VPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAF-MAGDC-QTSTQF 503
Query: 1374 NVTILDKP--SPPGKPNILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTTEWI-- 1428
V+ KP PP P + SS+ + W P + TI Y+VE +++ T WI
Sbjct: 504 CVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRC 563
Query: 1429 -SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP 1487
+ + + ++ ++ +++FR A+N S E + + +++P K
Sbjct: 564 HEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPL--KA 621
Query: 1488 LKNIT-TEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXX 1543
++ + E ++LT G W+ DG+ LK A + YE +R
Sbjct: 622 VQAVEGGEVTFSVDLTVASAG------EWFLDGQALK-ASSVYEIHCDRTRHTLTIREVP 674
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV----GDEWLVTAVIEGI 1599
+ F +G +E+S + ++ P +T + +V +E + A +
Sbjct: 675 ASLHGAQLKFVANG-IESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSD- 732
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY 1643
V W K+G L +Y + V+ ++++ R + Y
Sbjct: 733 QAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLY 776
Score = 81.4 bits (192), Expect = 3e-14
Identities = 54/209 (25%), Positives = 96/209 (45%), Gaps = 15/209 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F +PKA V G D L C++V P P ++W + + +A + D++
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYR--- 66
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT----GEKEPPQVIEPLKSMIVRQG 749
L I ++ G Y A N GEA + L++ E+ P ++ P S+ VR+G
Sbjct: 67 -LTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRP-TSIRVREG 124
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTHSITILKPKKVKDEGVYT 804
+V G+PRP ++W K+ + + + + G+ ++ I + + +D G Y
Sbjct: 125 SEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRI-RAARPRDGGTYE 183
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPP 833
++AEN G A +A + V+ + A P
Sbjct: 184 VRAENPLGAASAAAALVVDSDAADTASRP 212
Score = 81.0 bits (191), Expect = 4e-14
Identities = 90/392 (22%), Positives = 152/392 (38%), Gaps = 27/392 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVAT 567
AP F+ + +GS F C+V G PRP ++W + + ++ ++ +
Sbjct: 109 APHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASA 168
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
L IR P D GT+ A+N G AS+ L+V++ +D S +
Sbjct: 169 LRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRRE 228
Query: 628 IL--EGIPPT-FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
+ EG P + S + V EG L C + P+P+ W K ++V + V
Sbjct: 229 AMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWK-KDGQLVTEGRRHVVY 287
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + VLKI K+ G YT A N G+ +++ ++ E P + L+ +
Sbjct: 288 EDAQENF--VLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR--EPAVP-FKKRLQDL 342
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEG 801
VR+ ES + V P W K + A + +G +T+ + D+
Sbjct: 343 EVREKESATFLCE-VPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTV-RNVSADDDA 400
Query: 802 VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPV 861
VY E EG + T A + V+ + + T G + PV
Sbjct: 401 VYI--CETPEG-SRTVAELAVQGN---------LLRKLPRKTAVRVGDTAMFCVELAVPV 448
Query: 862 PSITWYRNNEIISPSETITQNFDGENIELVIT 893
+ W RN E + + + +G L I+
Sbjct: 449 GPVHWLRNQEEVVAGGRVAISAEGTRHTLTIS 480
Score = 78.6 bits (185), Expect = 2e-13
Identities = 55/195 (28%), Positives = 89/195 (45%), Gaps = 7/195 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P+ + K+ +V G+ LS Q+VGNP P ++W K+ +PV A DGD + +TI
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIK 851
L + D G Y +A N+ G A + + V+ + P F+ R I V+E
Sbjct: 70 L-DLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 852 LVARVTRNPVPSITWYRNNEIISPSETITQNFD--GENIELVITNVDSEIDSGDYKCVAS 909
RV +P P+++W ++ + + + GE L I D G Y+ A
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPR-DGGTYEVRAE 187
Query: 910 NSAGKSSHGARVTID 924
N G +S A + +D
Sbjct: 188 NPLGAASAAAALVVD 202
Score = 71.7 bits (168), Expect = 3e-11
Identities = 57/248 (22%), Positives = 106/248 (42%), Gaps = 8/248 (3%)
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI---LRDESCTAEVTV 1102
+ VW++DG+++ + +E L I D G Y+C L ++ ++ + V
Sbjct: 268 ETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVV 327
Query: 1103 VELPP-EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
V P RLQ+ +V + ATF E+ + WFK+ + + S + +G ++
Sbjct: 328 VREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTER 387
Query: 1162 KLKIYDCDLDDAGEYSCEV-GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+L + + DD Y CE S+ A L V+ N +LP V A VE+
Sbjct: 388 RLTVRNVSADDDAVYICETPEGSRTVAELAVQG---NLLRKLPRKTAVRVGDTAMFCVEL 444
Query: 1221 PDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLK 1280
V W + + + + + ++ + TL I +C +D + + D +++T+
Sbjct: 445 AVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFC 504
Query: 1281 VEVVEFPP 1288
V PP
Sbjct: 505 VSAPRKPP 512
Score = 70.5 bits (165), Expect = 6e-11
Identities = 60/207 (28%), Positives = 95/207 (45%), Gaps = 22/207 (10%)
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVI-LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDT- 786
T E + PQV+E L+ + V G + +V G P P + W K+ +P+ A D
Sbjct: 5254 TDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKK 5313
Query: 787 --HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV---EEPTEENAE-------PPL 834
H++ I+ + +D G Y N+ G A +SA + V +EP E+ A PP
Sbjct: 5314 ILHTLEIISVTR-EDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPR 5372
Query: 835 FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-----IISP-SETITQNFDGENI 888
+ RF VK+ +I +V PVP++ W R I P + T +
Sbjct: 5373 MLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQH 5432
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKS 915
LV+ +V + G Y C+ASN+AG++
Sbjct: 5433 SLVLLDVGRQ-HQGTYTCIASNAAGQA 5458
Score = 68.5 bits (160), Expect = 2e-10
Identities = 50/194 (25%), Positives = 79/194 (40%), Gaps = 11/194 (5%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK---SDGDTHSIT 790
PP E L GE+V L+ +V G P+P I+W K+ K V+ P D D
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
IL D G Y A ++ G T I V+ PP F+N+ + E
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ-------VPPRFVNKVRASPFVEGEDA 6125
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETI-TQNFDGENIELVITNVDSEIDSGDYKCVAS 909
+ + P P I WY++ +++ T + + +++ S+ D G Y+C
Sbjct: 6126 QFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELV 6185
Query: 910 NSAGKSSHGARVTI 923
N G + A + I
Sbjct: 6186 NRLGSARASAELRI 6199
Score = 68.1 bits (159), Expect = 3e-10
Identities = 33/96 (34%), Positives = 49/96 (51%), Gaps = 1/96 (1%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATL 568
P FV K+R +G QF C +EG P PQI W++ A++ FQ + + L
Sbjct: 6108 PRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVL 6167
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
VIR ED G + C N G A ++ EL +++P+
Sbjct: 6168 VIRAASKEDLGLYECELVNRLGSARASAELRIQSPM 6203
Score = 64.9 bits (151), Expect = 3e-09
Identities = 43/188 (22%), Positives = 76/188 (40%), Gaps = 9/188 (4%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK-----ATYENRXXXX 1536
P E+ L + T E E ++L C G P+P ++WY+DGK ++ +
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVI 1596
Y C A + G T + +Q P N+ G++ T I
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPP--RFVNKVRASPFVEGEDAQFTCTI 6131
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTS--VIRIKELKRSHSSKYTIEASNTAGTS 1654
EG P P++ WYK+G L ++ ++ ++ V+ I+ + Y E N G++
Sbjct: 6132 EGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSA 6191
Query: 1655 SVEVTLKV 1662
L++
Sbjct: 6192 RASAELRI 6199
Score = 61.3 bits (142), Expect = 4e-08
Identities = 57/221 (25%), Positives = 89/221 (40%), Gaps = 26/221 (11%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F+ + + G CQ+ G P PQ++W + + F++ D D +
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGD-LY 65
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
L I ++ D+G + C A+NA G A + L V+A + +E
Sbjct: 66 RLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAA--CAEQA-------------- 109
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
P F +P + V EGS+ CR+ P P ++W G + + V +E
Sbjct: 110 -------PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEE 162
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
S L+I + GTY V A N G AS L +
Sbjct: 163 LGE--ASALRIRAARPRDGGTYEVRAENPLGAASAAAALVV 201
Score = 60.1 bits (139), Expect = 9e-08
Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 7/156 (4%)
Query: 1597 EGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
E +P E WY NG ++ +D ++ +T + ++ + H+ + T + ++
Sbjct: 4457 EAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASAR 4516
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
+ V L + D P E V+ R S +VT+ W P+ DGG L Y +E E +W
Sbjct: 4517 LTV-LGLPDPPEDAE--VVAR--SSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRL 4571
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE 1751
++ E + L Y FRV A PVG E
Sbjct: 4572 CHELVPGPEC-VVDGLAPGETYRFRVAAVGPVGAGE 4606
Score = 59.3 bits (137), Expect = 1e-07
Identities = 50/213 (23%), Positives = 98/213 (46%), Gaps = 10/213 (4%)
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS--PSETITQNFDGENIE 889
PP F + T + T+KL RVT P P I+WY++ + + P + ++ DG +
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDG-SCA 6071
Query: 890 LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILE 949
L++ ++ +DSG Y C A+++AG S ++ + V FV ++ S EG+
Sbjct: 6072 LILDSLTG-VDSGQYMCFAASAAGNCSTLGKILVQVPP-RFVNKVRAS-PFVEGEDAQFT 6128
Query: 950 C--QTSHTVSTKWYHNKKEISGMDHREIIQEGRX--XXXXXXXXXXXDVGVIKCIVKDQE 1005
C + + +WY + ++ + + + E R D+G+ +C + ++
Sbjct: 6129 CTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRL 6188
Query: 1006 TSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
S + I + + Q+ +E+ VA +EV
Sbjct: 6189 GSARASAELRIQSPMLQAQEQCHREQLVAAVEV 6221
Score = 57.2 bits (132), Expect = 6e-07
Identities = 27/94 (28%), Positives = 48/94 (51%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F E+L G TV+ C+V G P+P I+W++ ++ + D D L+
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ + D+G + C A +AAG S+ +++V+ P
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVP 6107
Score = 55.2 bits (127), Expect = 2e-06
Identities = 43/197 (21%), Positives = 86/197 (43%), Gaps = 11/197 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F ++ + G + L CR+ P+P I+W G+ + D + + IE D C
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPH-HILIE-DPDGSC 6070
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+++ + ++ G Y A + G S + ++ PP+ + +++ +GE
Sbjct: 6071 ALI-LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQV----PPRFVNKVRASPFVEGEDA 6125
Query: 753 ILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTH-SITILKPKKVKDEGVYTLKAE 808
+ + G P P I W K+ + T S+ + + +++ +D G+Y +
Sbjct: 6126 QFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELV 6185
Query: 809 NSEGIAETSAVITVEEP 825
N G A SA + ++ P
Sbjct: 6186 NRLGSARASAELRIQSP 6202
Score = 54.4 bits (125), Expect = 4e-06
Identities = 30/119 (25%), Positives = 54/119 (45%), Gaps = 3/119 (2%)
Query: 815 ETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
ET A + EP + P+F+ Q V++ + VT P+PS+ W+++ +
Sbjct: 5105 ETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGK 5164
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
++ + N D + +I D G Y+C+A NS G SS A + +D+ +
Sbjct: 5165 LLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDY 5223
Score = 53.2 bits (122), Expect = 1e-05
Identities = 69/334 (20%), Positives = 125/334 (37%), Gaps = 24/334 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
+Q P+F G ++ EC V + W + + + + D
Sbjct: 4893 KQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDG 4952
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I + DAG +TC N G + + ++V GSE
Sbjct: 4953 TCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVVVS------GSESEAESSSGGELDDA 5006
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLEC-RLVAIPEPDIAW-LFKGEE---IVPDEN 679
+ F K A+ DE ++ L A PE W ++ +E + E
Sbjct: 5007 FRRAARRLHRLFRTKSPAEVSDE--ELFLSADEGPAEPEEPADWQTYREDEHFICIRFEA 5064
Query: 680 ISVA---IESDMHMYCSVLKITNVKKFQEGTYTV-VAVNREGEASL--PIVLKIKTGEKE 733
++ A + M+ ++ +K ++G V + +++E A + P L
Sbjct: 5065 LTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDA 5124
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHSI 789
P + L++ V+ G V V G P P++ W K+ K ++ + + H +
Sbjct: 5125 APVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
I+ D GVY AENS G++ T A + V+
Sbjct: 5185 -IITAVVPADMGVYRCLAENSMGVSSTKAELRVD 5217
Score = 48.8 bits (111), Expect = 2e-04
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 6/118 (5%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHE 1924
P P + V +S +VTL W P S+GG + Y +E K W V G E
Sbjct: 4523 PDPPEDAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGP--E 4580
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRL-EKHATVPSPPTAPLEIRMVGS 1980
++ + + FR++A VG P Q+VRL E VP P+AP E R V +
Sbjct: 4581 CVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-ESRQVAA 4637
Score = 46.8 bits (106), Expect = 9e-04
Identities = 35/155 (22%), Positives = 57/155 (36%), Gaps = 4/155 (2%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKR-TLIIRKCTEDDQCEYTCVLLDAKST-TKLKVEVV 1284
++WYK ++ LI D LI+ T D +Y C A + L +V
Sbjct: 6045 ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILV 6104
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA- 1343
+ PP+ V+ R G D + P P W + ++ + + +S
Sbjct: 6105 QVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL 6164
Query: 1344 -SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
L I+ D G+Y+ L N G A + I
Sbjct: 6165 LVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/180 (23%), Positives = 75/180 (41%), Gaps = 15/180 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F+ + + F V A L +I + T V WE+D + + ++ + G + +L
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGA-RFRLAQDGDLYRLT 68
Query: 1076 IRNTSVHDEGEYSCILRDE----------SCTAEVTVVELPPEIITRLQNQKVNKGNKAT 1125
I + ++ D G+Y C R+ AE E P + R + +V +G++AT
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 1126 FEIELTKGD-ALVRWFKDGSEIQFSNHIQLTID--GKKQKLKIYDCDLDDAGEYSCEVGN 1182
F + V W KDG + + ++ ++ G+ L+I D G Y N
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAEN 188
Score = 46.0 bits (104), Expect = 0.001
Identities = 48/203 (23%), Positives = 78/203 (38%), Gaps = 13/203 (6%)
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP+ L + G +T ++ W+KDG +Q H L D
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 1165 IYDCDLD-DAGEYSC----EVGN-SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I D D+G+Y C GN S IL P +R F+ DA T
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFV---EGEDAQFTC 6129
Query: 1219 EIPDETL-DVTWYKKKSVIEDTEKFTLISDVKK--RTLIIRKCTEDDQCEYTCVLLDAKS 1275
I + WYK +++ KF +S+ + L+IR +++D Y C L++
Sbjct: 6130 TIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLG 6189
Query: 1276 TTKLKVEVVEFPPKIVDYEREYR 1298
+ + E+ P + E+ +R
Sbjct: 6190 SARASAELRIQSPMLQAQEQCHR 6212
Score = 45.6 bits (103), Expect = 0.002
Identities = 45/201 (22%), Positives = 81/201 (40%), Gaps = 15/201 (7%)
Query: 1200 LRLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
L P+ +V DA L+ +I + T V+W K + + +F L D L I
Sbjct: 13 LTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDL 72
Query: 1259 TEDDQCEYTC----VLLDAKSTTKLKVEV----VEFPPKIVDYEREYRIKRGSDVTLLVD 1310
D +Y C + +A + L+V+ E P + R++ GS+ T
Sbjct: 73 ALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCR 132
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPSID--SKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P+P W + + + + + ++ ++++L I+ D G Y++R EN G
Sbjct: 133 VGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGA 192
Query: 1369 ADVEMNVTI----LDKPSPPG 1385
A + + D S PG
Sbjct: 193 ASAAAALVVDSDAADTASRPG 213
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+ L PK + +V C P+ + W++ + PS+ F+M + +A L I
Sbjct: 2470 VLTRPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQ-MAELRI 2527
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+ P DAG + C AG A S+TE+ VEA
Sbjct: 2528 LRLMPADAGVYRC----QAGSAHSSTEVTVEA 2555
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/90 (30%), Positives = 41/90 (45%)
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
PE V A D L +E+ E +V W+K I+ +F ++S +++ L+I+ T +D
Sbjct: 4630 PESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAED 4689
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
Q EY C L V P VD
Sbjct: 4690 QGEYHCGLAQGSICPAAATFQVALSPASVD 4719
Score = 44.0 bits (99), Expect = 0.006
Identities = 27/95 (28%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 1092 RDESCTAEVTVVELPPEIITRLQNQKVNKGNK-ATFEIELTKGDALVR--WFKDGSEIQF 1148
R++ T T P+++ L++ +V G + A F++++ KG R WFKDG +
Sbjct: 5245 REQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKV-KGYPAPRLYWFKDGQPLTA 5303
Query: 1149 SNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
S HI++T L+I +D+G+Y+ + N+
Sbjct: 5304 SAHIRMTDKKILHTLEIISVTREDSGQYAAYISNA 5338
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 1031 KDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI 1090
+DV+ LE+E+ +E +V+W + E I+P +++ +G + L I+ + D+GEY C
Sbjct: 4639 EDVS-LELEVVAEAGEVIWHKGMERIQP-GGRFEVVSQGRQQMLVIKGFTAEDQGEYHCG 4696
Query: 1091 LRDES-CTAEVTV-VELPP 1107
L S C A T V L P
Sbjct: 4697 LAQGSICPAAATFQVALSP 4715
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 1965 VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTL 2024
+P PP E+ S+ V SW P DGG L GY + +++ W ++ V
Sbjct: 4522 LPDPPE-DAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHEL-VPGP 4579
Query: 2025 KFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
+ + L+ TY R+ A +G EP+
Sbjct: 4580 ECVVDGLAPGETYRFRVAAVGPVGAGEPV 4608
Score = 42.7 bits (96), Expect = 0.014
Identities = 28/80 (35%), Positives = 40/80 (50%), Gaps = 4/80 (5%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGK-KQKL 1163
P +T LQNQ+V G +F+ +T G + VRWFKDG ++ +H + D + +L
Sbjct: 5126 PVFLTELQNQEVQDGYPVSFDCVVT-GQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184
Query: 1164 KIYDCDLDDAGEYSCEVGNS 1183
I D G Y C NS
Sbjct: 5185 IITAVVPADMGVYRCLAENS 5204
Score = 42.3 bits (95), Expect = 0.018
Identities = 23/94 (24%), Positives = 42/94 (44%), Gaps = 1/94 (1%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVI 892
P F+ R + V L ++ NP P ++W ++ + ++ DG+ L I
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 893 TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
++ DSG Y C A N+ G++ + +D E
Sbjct: 70 LDLALG-DSGQYVCRARNAIGEAFAAVGLQVDAE 102
Score = 41.9 bits (94), Expect = 0.024
Identities = 41/187 (21%), Positives = 67/187 (35%), Gaps = 15/187 (8%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXX 1544
K +D L+C G P P+V+W +D + + A +
Sbjct: 17 KAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGD 76
Query: 1545 XXXYKCIAFNDHGEVETSCVVGI-------QQKPVITISNEDIKQKHKVGDEWLVTAVIE 1597
Y C A N GE + + + +Q P + I+ + G E +
Sbjct: 77 SGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVRE--GSEATFRCRVG 134
Query: 1598 GIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
G P P V W K+G +L + +E + S +RI+ + Y + A N G +S
Sbjct: 135 GSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAAS 194
Query: 1656 VEVTLKV 1662
L V
Sbjct: 195 AAAALVV 201
Score = 41.9 bits (94), Expect = 0.024
Identities = 30/102 (29%), Positives = 38/102 (37%), Gaps = 2/102 (1%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
IL +PP F K +A EG D C + P P I W G + E
Sbjct: 6102 ILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPR 6161
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT 729
+ VL I K G Y VNR G A L+I++
Sbjct: 6162 SGLL--VLVIRAASKEDLGLYECELVNRLGSARASAELRIQS 6201
Score = 40.7 bits (91), Expect = 0.056
Identities = 23/81 (28%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-- 1653
++G P P + W+K+G L +T K+ + I + R S +Y SN G
Sbjct: 5284 VKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAY 5343
Query: 1654 SSVEVTLKVYDKP-SKPEGPV 1673
SS + ++ D+P KP V
Sbjct: 5344 SSARLLVRGPDEPEEKPASDV 5364
Score = 39.9 bits (89), Expect = 0.098
Identities = 23/78 (29%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +TR + V+ G AT ++ V W KD + +L DG +L I
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 1166 YDCDLDDAGEYSCEVGNS 1183
D L D+G+Y C N+
Sbjct: 70 LDLALGDSGQYVCRARNA 87
Score = 39.9 bits (89), Expect = 0.098
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 1582 QKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS-VIRIKELKRS 1638
Q +V D + V+ V+ G P P V W+K+G LE D Y I ++ + I + +
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKV 1662
Y A N+ G SS + L+V
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRV 5216
Score = 39.1 bits (87), Expect = 0.17
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F++ L + T+ +C+V P + W + + PS + + LV+
Sbjct: 2648 VFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTA-GTRGLVV 2705
Query: 571 REVFPEDAGTFTC 583
+V PEDAG +TC
Sbjct: 2706 HDVSPEDAGLYTC 2718
Score = 38.7 bits (86), Expect = 0.23
Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 509 API-FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
AP+ F+ +L+ + +G T C++ + W + + + P +QM D A
Sbjct: 3977 APVRFLRELQHQEVDEGGTAHLCCELSR-AGASVEWRKGSLQLFPCAKYQMV-QDGAAAE 4034
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFAS 593
L++R V EDAG +TC + AS
Sbjct: 4035 LLVRGVEQEDAGDYTCDTGHTQSMAS 4060
Score = 38.3 bits (85), Expect = 0.30
Identities = 38/182 (20%), Positives = 71/182 (39%), Gaps = 14/182 (7%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYEN---RXXXXXXXXXXX 1543
+ T + L+C G P+P+ W +DG+ + + YE+
Sbjct: 245 RTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPP- 1602
Y C A N G+ +S +V + ++P + Q +V ++ T + E +P P
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLV-VVREPAVPFKKR--LQDLEVREKESATFLCE-VPQPS 360
Query: 1603 -EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY---TIEASNTAGTSSVEV 1658
E W+K +L +Y I + + ++ + + Y T E S T +V+
Sbjct: 361 TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQG 420
Query: 1659 TL 1660
L
Sbjct: 421 NL 422
Score = 38.3 bits (85), Expect = 0.30
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1114 QNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDA 1173
++++V G + E+E+ V W K IQ ++ G++Q L I +D
Sbjct: 4631 ESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQ 4690
Query: 1174 GEYSCEVG-NSKCTAILTVE 1192
GEY C + S C A T +
Sbjct: 4691 GEYHCGLAQGSICPAAATFQ 4710
Score = 37.5 bits (83), Expect = 0.52
Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
++ + G P PE +W K+G + + + + ++ V++I K+S YT ASN
Sbjct: 257 LSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNL 316
Query: 1651 AGTSSVEVTLKVYDKPSKP 1669
G + V L V +P+ P
Sbjct: 317 VGQTYSSV-LVVVREPAVP 334
Score = 37.5 bits (83), Expect = 0.52
Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F+ L +G F+C V + WFR A+++PS+ F + + +L I
Sbjct: 1901 FMSGLSTVVAEEGGEATFQCVVSPSD-VAVVWFRDGALLQPSEKFAISQSGAS-HSLTIS 1958
Query: 572 EVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++ EDAG T A G +SS + EAP+
Sbjct: 1959 DLVLEDAGQITV---EAEGASSSAALRVREAPV 1988
Score = 37.5 bits (83), Expect = 0.52
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V+F C+V + W Q ++ ++ ++ D + TL ++ V PEDAGT +
Sbjct: 4176 VEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLG 4235
Query: 587 NAAGFASSTT---ELIVEAPLSD 606
N A A T E+ + PL D
Sbjct: 4236 NHASSAQLTVRAPEVTILEPLQD 4258
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 3/54 (5%)
Query: 1131 TKGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+K D RW KDG E+ +HI DG L I D DAG Y+C+V N
Sbjct: 4923 SKADVRARWLKDGVELTDGRHHHIDQLGDG-TCSLLITGLDRADAGCYTCQVSN 4975
Score = 35.1 bits (77), Expect = 2.8
Identities = 24/101 (23%), Positives = 44/101 (43%), Gaps = 2/101 (1%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTI-KLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E T + + P + +++ V + K +V P P + W+++ + ++ S I
Sbjct: 5251 ESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMT 5310
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
L I +V E DSG Y SN+ G + AR+ +
Sbjct: 5311 DKKILHTLEIISVTRE-DSGQYAAYISNAMGAAYSSARLLV 5350
Score = 34.7 bits (76), Expect = 3.7
Identities = 14/47 (29%), Positives = 22/47 (46%)
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
T +P L+N + + C+ G P P V W++DGK L+
Sbjct: 5121 TSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLE 5167
Score = 34.3 bits (75), Expect = 4.9
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 5/95 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+F E L+ +GST +C++ P + W + ++ + + A LV
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCELSE-PTATVVWSKGGLQLQANGRREPRLQGCT-AELV 3947
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++++ ED G +TC + A+S T + AP+
Sbjct: 3948 LQDLQREDTGEYTCTCGSQ---ATSATLTVTAAPV 3979
Score = 33.5 bits (73), Expect = 8.5
Identities = 34/172 (19%), Positives = 64/172 (37%), Gaps = 4/172 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VGD + + +P V W +N ++ I+ + + I + +
Sbjct: 433 RVGDTAMFCVEL-AVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVA 491
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLD-DGGLELTKYAI 1703
A + ++ V+ P PV+ + SV + W PP + + + Y +
Sbjct: 492 FMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARME-SSVILSWSPPPHGERPVTIDGYLV 550
Query: 1704 EKHEPDNNRWIKVADVD-RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE 1754
EK + WI+ + + + + E + FRV A N G S LE
Sbjct: 551 EKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLE 602
Score = 33.5 bits (73), Expect = 8.5
Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+T C+V P+ ++TW++ + S +M LV+++V DAG ++C
Sbjct: 1181 GTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGCT-RRLVVQQVGKADAGEYSC 1238
Query: 584 VA 585
A
Sbjct: 1239 EA 1240
Score = 33.5 bits (73), Expect = 8.5
Identities = 21/92 (22%), Positives = 40/92 (43%), Gaps = 3/92 (3%)
Query: 1781 NESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKX-XXXXXXXXARIQKLSINTTYQFR 1838
+ +V ++W +GG + Y+VE+K+ +W+ + L+ TY+FR
Sbjct: 4536 SHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFR 4595
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTP-PSQP 1869
+ A +G P + + + P P QP
Sbjct: 4596 VAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQP 4627
>AL353593-3|CAI19285.1| 6620|Homo sapiens obscurin, cytoskeletal
calmodulin and titin-interacting RhoGEF protein.
Length = 6620
Score = 192 bits (467), Expect = 2e-47
Identities = 166/673 (24%), Positives = 287/673 (42%), Gaps = 42/673 (6%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
++ +P F++ + + EG+ +L C L + + W KG E + D + + +
Sbjct: 3445 VKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP--VEWR-KGPENLRDGDRYILRQEGT 3501
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y V A+L I P + IE +K+ R+
Sbjct: 3502 R--CE-LQICGLAMADAGEYLCVCGQERTSATLTI-------RALPARFIEDVKNQEARE 3551
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTL 805
G + +L ++ N + W K ++ ++ + DG + I + + D G Y+
Sbjct: 3552 GATAVLQCEL--NSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQI-RGLAMADTGEYSC 3608
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
G TSA++TV A P F + E T V R + + +
Sbjct: 3609 VC----GQERTSAMLTVR------ALPIKFTEGLRNEEATEGATA--VLRCELSKMAPVE 3656
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W++ +E + + + DG EL I + +E D+G+Y C+ GK A +T+
Sbjct: 3657 WWKGHETLRDGDRHSLRQDGARCELQIRGLVAE-DAGEYLCMC----GKERTSAMLTVRA 3711
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
F++ L+ E EG T L C+ S +W + + D + Q+G
Sbjct: 3712 MPSKFIEGLRNE-EATEGDTATLWCELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQ 3770
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G C+ + TS L V+ FI +++ E +E A+L+ E+ S+ A
Sbjct: 3771 IRGLAVVDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCEL-SKAA 3829
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W + E ++ ++Y + G +L I SV D GEYSC+ E +A +TV
Sbjct: 3830 PVEWRKGSETLRGG-DRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAP 3888
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P LQ+ + +G+ AT + EL++ A V W K G ++Q + + + G +L +
Sbjct: 3889 QPVFREPLQSLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVL 3948
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D +D GEY+C G+ +A LTV + F LR + V A+L E+
Sbjct: 3949 QDLQREDTGEYTCTCGSQATSATLTVTAAPVRF-LRELQHQEVDEGGTAHLCCELSRAGA 4007
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-- 1283
V W K + K+ ++ D L++R ++D +YTC +S L V V
Sbjct: 4008 SVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRVPR 4067
Query: 1284 VEFPPKIVDYERE 1296
+F ++ E+E
Sbjct: 4068 PKFKTRLQSLEQE 4080
Score = 189 bits (461), Expect = 8e-47
Identities = 271/1259 (21%), Positives = 487/1259 (38%), Gaps = 118/1259 (9%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F L+ T + V EC++ P + W + ++ + + + + R
Sbjct: 2168 FSRPLQDVVTTEKEKVTLECELSR-PNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYR 2226
Query: 572 EVFPEDAGTFTCVAKNAAGFAS-----STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
F D G + C A +A AS T LI L++ E+
Sbjct: 2227 CEFA-DQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLR- 2284
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
++ +P T + + + E +LEC+ V+ + W +E+ P + +
Sbjct: 2285 --VKELPVTLVRPLRDKIAMEKHRGVLECQ-VSRASAQVRWFKGSQELQPGPKYELVSDG 2341
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+Y ++ I++V E TYT A + + A + E++ ++ L+ + V
Sbjct: 2342 ---LYRKLI-ISDVHAEDEDTYTCDAGDVKTSAQFFV-------EEQSITIVRGLQDVTV 2390
Query: 747 RQGESVILSAQV-VGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGV 802
+ + + + RP W ++A + + +G H + + + V
Sbjct: 2391 MEPAPAWFECETSIPSVRPP-KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPV 2449
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ + G + +SA + V + P + + T +E ++ L P
Sbjct: 2450 HF-----TVGKSRSSARLVVSDI------PVVLTRPLEPKTGRELQSVVLSCDFRPAP-K 2497
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
++ WY+++ +SPSE + +G+ EL I + D+G Y+C AG + VT
Sbjct: 2498 AVQWYKDDTPLSPSEKFKMSLEGQMAELRILRL-MPADAGVYRC----QAGSAHSSTEVT 2552
Query: 923 IDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRX 981
++ +VT LQ + TEEG C+ SH +W N + EI +GR
Sbjct: 2553 VEAREVTVTGPLQDAEATEEG-WASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRR 2611
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
D G+++ TS L V+ F++ L D +E+ L+ E++
Sbjct: 2612 HTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVS 2671
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
A VVW +DG + P +KYDF R L + + S D G Y+C + E A V
Sbjct: 2672 DPEAHVVWRKDGVQLGPS-DKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVR 2730
Query: 1102 VVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGK 1159
V +L I RL+ +V +G +FE L+ A W G + S+ Q T G+
Sbjct: 2731 VHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGR 2790
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVE 1219
K L + + DAGE V A L V E L + + P D L E
Sbjct: 2791 KYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGE-DVELRCE 2849
Query: 1220 IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
+ V W K + I ++K+ ++ + L+IR + D EYTC + +KST L
Sbjct: 2850 LSRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASL 2909
Query: 1280 KVEVVE--FPPKIVDYEREYRIKRGSDV-TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
VE F ++ + + E ++G+ V T ++ P W ++ +P
Sbjct: 2910 HVEEKANCFTEELTNLQVE---EKGTAVFTCKTEH---PAATVTWRKGLLELRASGKHQP 2963
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS 1396
S + + LTI +E D+ Y + G A + + + + +I+E D
Sbjct: 2964 SQEGLTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGR-----RVHIIE-DLED 3013
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
+++ G+S + + W K T + N + +
Sbjct: 3014 VDV------QEGSSATFRCRISPANYEPVHWFLDK--TPLHANELNEIDAQPGGYHVLTL 3065
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTV-EKP------LKNITTEPNEDIELTCIFGGVP 1509
++ + D+ T Y++ + + V EKP L + T ED+ L C
Sbjct: 3066 RQLALKDSG--TIYFEAGDQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCETSTCD 3123
Query: 1510 QPKVTWYRDGKKLKTA---KATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV 1565
P V W +DGK L+ + + ++E +R YKC A G +S +V
Sbjct: 3124 IP-VCWTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIV 3178
Query: 1566 GIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
+ +PV E +K + G + V+ + P V W N L +Y++ +
Sbjct: 3179 RVHARPVRF--QEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQE 3235
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ ++ L+ S +Y S + G + TL V P++ G + +E +
Sbjct: 3236 GAMLELVVRNLRPQDSGRY----SCSFGDQTTSATLTVTALPAQFIGKLRNKEAT----- 3286
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
+G + + K P W K ++ RD + YC+++ CE R +A
Sbjct: 3287 --------EGATATLRCELSKAAPVE--WRKGSETLRDGDRYCLRQDGAMCELQIRGLA 3335
Score = 180 bits (437), Expect = 7e-44
Identities = 169/669 (25%), Positives = 275/669 (41%), Gaps = 39/669 (5%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVIL 754
L I+ ++K TYT + A L + + +IE L+ + V++G S
Sbjct: 2972 LTISALEKADSDTYTCDIGQAQSRAQLLV-------QGRRVHIIEDLEDVDVQEGSSATF 3024
Query: 755 SAQVVGNPRPTITWCKNNKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENS 810
++ + W + P+ A G H +T L+ +KD G +A
Sbjct: 3025 RCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLT-LRQLALKDSGTIYFEA--- 3080
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G SA + V E +P +F + T+ E + LV + +P + W ++
Sbjct: 3081 -GDQRASAALRVTE------KPSVFSRELTDATITEGEDLTLVCETSTCDIP-VCWTKDG 3132
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
+ + S + +G +L+IT + DSG YKC A + S V + V F
Sbjct: 3133 KTLRGSARCQLSHEGHRAQLLITGATLQ-DSGRYKCEAGGACSSSI----VRVHARPVRF 3187
Query: 931 VKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ L K E EG L C S + KW + + D + QEG
Sbjct: 3188 QEAL-KDLEVLEGGAATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNL 3246
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVW 1049
D G C DQ TS L V +FI KL++ E E A L E+ S+ A V W
Sbjct: 3247 RPQDSGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCEL-SKAAPVEW 3305
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEI 1109
+ E ++ ++Y + G + +L IR ++ D EYSC+ +E +A +T+ +P
Sbjct: 3306 RKGSETLRDG-DRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHF 3364
Query: 1110 ITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
I RL++Q+ +G AT EL+K A V W K ++ + L DG +L+I
Sbjct: 3365 IGRLRHQESIEGATATLRCELSKA-APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423
Query: 1170 LDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+ DAGEYSC G + +A LTV+ FT L V T A L E+ + V W
Sbjct: 3424 VADAGEYSCVCGEERTSATLTVKALPAKFTEGLRNEEAVEGAT-AMLWCEL-SKVAPVEW 3481
Query: 1230 YKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPK 1289
K + D +++ L + + L I D EY CV +++ L + + P +
Sbjct: 3482 RKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRAL--PAR 3539
Query: 1290 IVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKK 1349
++ + + G+ L + + EW S+ ++ D L I+
Sbjct: 3540 FIEDVKNQEAREGATAVLQCELNSAAPV--EWRKGSETLRDGDRYSLRQDGTKCELQIRG 3597
Query: 1350 VENTDAGIY 1358
+ D G Y
Sbjct: 3598 LAMADTGEY 3606
Score = 170 bits (414), Expect = 4e-41
Identities = 196/889 (22%), Positives = 349/889 (39%), Gaps = 58/889 (6%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLV-AIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ +P F + K Q EG+ +L+C L A P + W E + + S+ +
Sbjct: 3797 VRALPARFIEDVKNQEAREGATAVLQCELSKAAP---VEWRKGSETLRGGDRYSLRQDGT 3853
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
C L+I + G Y+ V A+L + P EPL+S+
Sbjct: 3854 R---CE-LQIHGLSVADTGEYSCVCGQERTSATLTV-------RAPQPVFREPLQSLQAE 3902
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYT 804
+G + L ++ P T+ W K ++A + G T + +L+ + +D G YT
Sbjct: 3903 EGSTATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGCTAEL-VLQDLQREDTGEYT 3960
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P F+ Q V E GT L ++R S+
Sbjct: 3961 CTC----GSQATSATLTV------TAAPVRFLRELQHQEVDEGGTAHLCCELSRAGA-SV 4009
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + + + P DG EL++ V+ E D+GDY C G + A +++
Sbjct: 4010 EWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQE-DAGDYTC----DTGHTQSMASLSVR 4064
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHTVS---TKWYHNKKEISGMDHREIIQEGRX 981
V + F LQ S E E G L CQ S S +W E+ E+ +G
Sbjct: 4065 VPRPKFKTRLQ-SLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGAT 4123
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
D G C+ Q+T+ L V E +R L D EV + E++
Sbjct: 4124 RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVS 4183
Query: 1042 SETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
A V W G ++ + + G I L ++ + D G S L + + +A++
Sbjct: 4184 RAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQL 4243
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTID-G 1158
TV I+ LQ+ ++++G A+F+ L++ RW G +Q + +T++ G
Sbjct: 4244 TVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQG 4303
Query: 1159 KKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
L ++ L+DAG S VG C++ ++ + N +R E + +A
Sbjct: 4304 TLHLLTLHKVTLEDAGTVSFHVGT--CSSEAQLKVTAKNTVVRGLENVEALEGGEALFEC 4361
Query: 1219 EIPD-ETLDVTWYKKKSVIEDTEKFTLI--SDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
++ E TW + +E ++ + + L+++ D C T + D +
Sbjct: 4362 QLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGDMVT 4421
Query: 1276 TTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHT 1334
+ L V +I++ + ++ G+ +A P W +N ++
Sbjct: 4422 SAFLTVRGWRL--EILEPLKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSD 4479
Query: 1335 -KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEID 1393
+ D +L ++ + AG + C A +T+L P PP ++
Sbjct: 4480 WTVTADGSHHALLLRSAQPHHAG----EVTFACRDAVASARLTVLGLPDPPEDAEVVARS 4535
Query: 1394 SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFR 1452
S ++ + W P + G + Y VE +E T +W + + + + + L +YRFR
Sbjct: 4536 SHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFR 4595
Query: 1453 AYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIEL 1501
AV V + + ++ + K P P ++ ED+ L
Sbjct: 4596 VAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-ESRQVAAGEDVSL 4643
Score = 161 bits (392), Expect = 2e-38
Identities = 179/903 (19%), Positives = 342/903 (37%), Gaps = 56/903 (6%)
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
+DEG Y+ + G + V EP A+ L + Q E G ++
Sbjct: 863 QDEGTYSCRV----GEDSVDFRLRVSEPKVVFAKEQLARRKLQA----EAGASATLSCEV 914
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
+TWY++ + +S S + G LV+ + D+G+Y C AG
Sbjct: 915 AQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQA-GQADAGEYSC----EAGGQRL 969
Query: 918 GARVTIDVEKVTFVKH--LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHRE 974
+ + KV F K + E G + L C+ + WY + K++S
Sbjct: 970 SFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSCEVAQAQTEVMWYKDGKKLSSSLKVH 1029
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKL---QDFEVKEK 1031
+ +G D G C + Q S L + E F ++ + + +
Sbjct: 1030 VEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAG 1089
Query: 1032 DVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
A+L E+ +V W +DG+ + +K E +G R+L + D GEYSC
Sbjct: 1090 ASAMLSCEVAQAQTEVTWYKDGKKLS-SSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148
Query: 1092 RDESCTAEVTVVELPPEIITRLQN----QKVNKGNKATFEIELTKGDALVRWFKDGSEIQ 1147
+ + + + E P + + Q+ + G A E+ + V W+KDG ++
Sbjct: 1149 GGQRVSFHLHITE-PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLS 1207
Query: 1148 FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR--LPEF 1205
S+ +++ + G ++L + DAGEYSCE G + + L + EP F +
Sbjct: 1208 SSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNE 1267
Query: 1206 ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
+ A A L+ E+ +VTWYK + + K + + R L++++ + D E
Sbjct: 1268 VRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327
Query: 1266 YTCVLLDAKSTTKLKV-EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
YTC + + L V E K R+ + + G+ TL + A Q W +
Sbjct: 1328 YTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEV-AQAQTEVTWYKD 1386
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL--ENNCGHADVEMNVTILDKPS 1382
K + + + L +++ D G Y + DV + K
Sbjct: 1387 GKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQ 1446
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
P + + +S+ C E T + + + +++ + + ++ + T+ +
Sbjct: 1447 PVHREVQAQAGASTTLSC----EVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQ 1502
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
+ E S+ ++ + E K + + + E L+
Sbjct: 1503 QAGQA-------VAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLS 1555
Query: 1503 CIFGGVPQPKVTWYRDGKKL-KTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
C Q +VTWY+DGKKL ++K E Y C A G+
Sbjct: 1556 CEVAQA-QTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKA----GD 1610
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDK 1617
S + + + V+ + ++ + T E EV WYK+G KL +
Sbjct: 1611 QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS 1670
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASN---TAGTSSVEVTLKVYDKPSKPEGPVI 1674
+ + T + +++ ++ + +Y+ EA + E+ ++ ++P + E P++
Sbjct: 1671 KVRVEAVGCTRRLVVQQAGQAEAGEYSCEAGGQQLSFRLQVAELEPQISERPCRRE-PLV 1729
Query: 1675 MRE 1677
++E
Sbjct: 1730 VKE 1732
Score = 161 bits (392), Expect = 2e-38
Identities = 200/904 (22%), Positives = 364/904 (40%), Gaps = 67/904 (7%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ +P F++ + + EG+ +L C L + + W +KG E + D + ++ D
Sbjct: 3621 VRALPIKFTEGLRNEEATEGATAVLRCELSKMAP--VEW-WKGHETLRDGDRH-SLRQD- 3675
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y + A L + P + IE L++ +
Sbjct: 3676 GARCE-LQIRGLVAEDAGEYLCMCGKERTSAMLTV-------RAMPSKFIEGLRNEEATE 3727
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKA 807
G++ L ++ + + W K ++ ++ DGD HS+ + +++ G+ + A
Sbjct: 3728 GDTATLWCEL--SKAAPVEWRKGHETLR------DGDRHSLRQDGSRCELQIRGLAVVDA 3779
Query: 808 ENSE---GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P FI + +E T L +++ +
Sbjct: 3780 GEYSCVCGQERTSATLTVR------ALPARFIEDVKNQEAREGATAVLQCELSK--AAPV 3831
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + +E + + + DG EL I + S D+G+Y CV G+ A +T+
Sbjct: 3832 EWRKGSETLRGGDRYSLRQDGTRCELQIHGL-SVADTGEYSCVC----GQERTSATLTVR 3886
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXX 983
+ F + LQ S + EEG T L+C+ S T + W ++ RE +G
Sbjct: 3887 APQPVFREPLQ-SLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAE 3945
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G C Q TS L V F+R+LQ EV E A L E++
Sbjct: 3946 LVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCCELSRA 4005
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
A V W + + P KY + G +L +R D G+Y+C A ++V
Sbjct: 4006 GASVEWRKGSLQLFPCA-KYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVR 4064
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
P+ TRLQ+ + G+ A +L+ + A+V+W K+G E+ ++ G +
Sbjct: 4065 VPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATR 4124
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP 1221
+L I+ + D GEY+C G K A L V EP + L + V A+ D + E+
Sbjct: 4125 ELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVD-AEVTADEDVEFSCEVS 4183
Query: 1222 DE-TLDVTWYKKKSVIEDTEKFTL-ISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
V W + ++ E + + D + TL ++ T +D + L + S+ +L
Sbjct: 4184 RAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQL 4243
Query: 1280 KVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
V E I++ ++ ++ G D + W + ++ + +++
Sbjct: 4244 TVRAPEV--TILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVE 4301
Query: 1340 SKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI--LEIDSSS 1396
+ LT+ KV DAG + C ++ ++ VT G N+ LE +
Sbjct: 4302 QGTLHLLTLHKVTLEDAGTVSFHV-GTCS-SEAQLKVT-AKNTVVRGLENVEALEGGEAL 4358
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
+PE ++ ++ + + E + +N + ++NL+ S R A
Sbjct: 4359 FECQLSQPEVAAHTWLLDDEPVHTS-ENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAG 4417
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG-GVPQPKVTW 1515
+ V T + ++ +++ + +PLKN TC VP + +W
Sbjct: 4418 DMV--------TSAFLTVRGWRLE---ILEPLKNAAVRAGAQACFTCTLSEAVPVGEASW 4466
Query: 1516 YRDG 1519
Y +G
Sbjct: 4467 YING 4470
Score = 161 bits (390), Expect = 3e-38
Identities = 157/735 (21%), Positives = 292/735 (39%), Gaps = 46/735 (6%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ G+ +L C VA + ++ W G+++ + + ++ L + K
Sbjct: 1087 EAGASAMLSCE-VAQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRR----LVLPQAGKADA 1141
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G Y+ A + L I KE Q + + G + +LS +V P+
Sbjct: 1142 GEYSCEAGGQRVSFHLHITEPKGVFAKE--QSVH--NEVQAEAGTTAMLSCEVA-QPQTE 1196
Query: 766 ITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+TW K+ K + + + + G T + + + K D G Y+ +A G S + +
Sbjct: 1197 VTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA-DAGEYSCEA----GGQRVSFQLHI 1251
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
EP A+ L N E+ + + L V + +TWY++ + +S S +
Sbjct: 1252 TEPKAVFAKEQLVHN---EVRTEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRIE 1307
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH--LQKSYET 940
G +LV+ + D+G+Y C AG + + K F K + +
Sbjct: 1308 AAGCMRQLVVQQA-GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA 1362
Query: 941 EEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
E G L C+ + WY + K++S + G D G C
Sbjct: 1363 EAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSC 1422
Query: 1000 IVKDQETSTMLVVKETIPEFIRKL---QDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
Q S L V E F ++ ++ + + L E+ +V+W +DG+ +
Sbjct: 1423 EAGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL 1482
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQ-- 1114
+K E G R+L ++ GEYSC + + + V E P + + Q
Sbjct: 1483 S-FSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAE-PKAVFAKEQPA 1540
Query: 1115 --NQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+ G AT E+ + V W+KDG ++ S+ +++ G ++L + + D
Sbjct: 1541 SREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQAD 1600
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEF--ILVPANTDAYLTVEIPDETLDVTWY 1230
AGEYSC+ G+ + + L V EP + F P + A A L+ E+ +VTWY
Sbjct: 1601 AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWY 1660
Query: 1231 KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
K + + K + + R L++++ + + EY+C +++V E P+I
Sbjct: 1661 KDGKKLSSSSKVRVEAVGCTRRLVVQQAGQAEAGEYSCEA--GGQQLSFRLQVAELEPQI 1718
Query: 1291 VD--YERE-YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
+ RE +K D+ L W+ + I++ K + + + +LT+
Sbjct: 1719 SERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTV 1778
Query: 1348 KKVENTDAGIYKLRL 1362
+ D+ IY R+
Sbjct: 1779 HGAQVLDSAIYSCRV 1793
Score = 152 bits (369), Expect = 1e-35
Identities = 142/641 (22%), Positives = 260/641 (40%), Gaps = 32/641 (4%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ G+ L C VA + ++ W G+++ + V L + + +
Sbjct: 1639 EAGASATLSCE-VAQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRR----LVVQQAGQAEA 1693
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G Y+ A ++ L + +++ E P EPL +V++ E +IL+A + T
Sbjct: 1694 GEYSCEAGGQQLSFRLQVA-ELEPQISERPCRREPL---VVKEHEDIILTATLATPSAAT 1749
Query: 766 ITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+TW K+ + K T S GDTH++T+ +V D +Y+ + +EG + V
Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTV-HGAQVLDSAIYSCRV-GAEG---QDFPVQV 1804
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
EE + F + + + GT+ L ++ + W N + +
Sbjct: 1805 EEVAAK------FCRLLEPVCGELGGTVTLACELSP-ACAEVVWRCGNTQLRVGKRFQMV 1857
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
+G L + + +E D+G+Y C + + A++T+ V +V + EE
Sbjct: 1858 AEGPVRSLTVLGLRAE-DAGEYVCESRDD----HTSAQLTVSVPRVVKFMSGLSTVVAEE 1912
Query: 943 GKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
G +C S + V+ W+ + + + I Q G D G I
Sbjct: 1913 GGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEA 1972
Query: 1002 KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKN 1061
+ +S L V+E F +KL+ V+E+ LEVE+ ++ W R+ + P KN
Sbjct: 1973 EGASSSAALRVREAPVLFKKKLEPQTVEERSSVTLEVELTRPWPELRWTRNATALAPGKN 2032
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKG 1121
+ G +L + N D G + C D+ A++TV ++ LQ + +
Sbjct: 2033 -VEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQ 2091
Query: 1122 NKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG 1181
AT E++L+ D W +DG Q L + G L + +D+G +
Sbjct: 2092 GTATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAE 2151
Query: 1182 NSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEK 1241
+A L V E ++F+ L + ++ L E+ +DV W K + +
Sbjct: 2152 GVHTSARLVVTELPVSFSRPLQD-VVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKT 2210
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
+ + R+L I +C DQ Y C DA+S+ +KV+
Sbjct: 2211 MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQ 2251
Score = 138 bits (334), Expect = 2e-31
Identities = 135/567 (23%), Positives = 235/567 (41%), Gaps = 35/567 (6%)
Query: 632 IPPTFSKKP---KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ P S++P + V E DI+L L + WL G EI + A + D
Sbjct: 1714 LEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDT 1773
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
H L + + Y+ V EG+ P+ +++ + +++EP+ +
Sbjct: 1774 H----TLTVHGAQVLDSAIYSC-RVGAEGQ-DFPV--QVEEVAAKFCRLLEPVCGEL--- 1822
Query: 749 GESVILSAQVVGNPRPTITWCKNN--KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G +V L+ ++ + C N + K ++G S+T+L + +D G Y +
Sbjct: 1823 GGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLG-LRAEDAGEYVCE 1881
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
+ + TSA +TV P F++ + +E G V+ + V ++ W
Sbjct: 1882 SRDDH----TSAQLTVSVPRVVK-----FMSGLSTVVAEEGGEATFQCVVSPSDV-AVVW 1931
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+R+ ++ PSE + G + L I+++ E D+G + + G SS A + +
Sbjct: 1932 FRDGALLQPSEKFAISQSGASHSLTISDLVLE-DAGQ---ITVEAEGASSSAA-LRVREA 1986
Query: 927 KVTFVKHLQKSYETEEGKTVILECQ-TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
V F K L+ EE +V LE + T +W N ++ + EI EG
Sbjct: 1987 PVLFKKKLEPQ-TVEERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLV 2045
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G C D +T L V+ +R LQ E +E+ A +EV+++
Sbjct: 2046 LHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADV 2105
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
D W RDG + + RG + L + D G +A + V EL
Sbjct: 2106 DGSWTRDGLRFQQGPTCH-LAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTEL 2164
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P LQ+ + K T E EL++ + VRW KDG E++ + + G + L I
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTI 2224
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVE 1192
Y C+ D G Y C+ +++ +A + V+
Sbjct: 2225 YRCEFADQGVYVCDAHDAQSSASVKVQ 2251
Score = 134 bits (325), Expect = 2e-30
Identities = 164/758 (21%), Positives = 285/758 (37%), Gaps = 49/758 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P F K +E + L+C V+ PE + W G ++ P + +
Sbjct: 2646 PVVFLKALDDLSAEERGTLALQCE-VSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRG-- 2702
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L + +V G YT + E A + V + G + + LK+M V +GES
Sbjct: 2703 --LVVHDVSPEDAGLYTCHVGSEETRARVR-VHDLHVG------ITKRLKTMEVLEGESC 2753
Query: 753 ----ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
+LS + +P K G + I +++ D G
Sbjct: 2754 SFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKY-ILVVREAAPSDAGEVVFSVR 2812
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
G+ +++I E P I ++ V ++L ++R P + W +
Sbjct: 2813 ---GLTSKASLIVRERPAA-------IIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLK 2861
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
+ + I S+ +G LVI + D+G+Y C A KS+ A + ++ +
Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLK-DAGEYTCEVE--ASKST--ASLHVEEKAN 2916
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXX 987
F + L + + EE T + C+T H +T W E+ + QEG
Sbjct: 2917 CFTEELT-NLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADV 1047
D C + ++ L+V+ I L+D +V+E A I+ +
Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEP 3035
Query: 1048 V-WERDGEIIKPKK-NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W D + + N+ D + G+ L +R ++ D G D+ +A + V E
Sbjct: 3036 VHWFLDKTPLHANELNEIDAQPGGY-HVLTLRQLALKDSGTIYFEAGDQRASAALRVTEK 3094
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P L + + +G T E + D V W KDG ++ S QL+ +G + +L I
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSHEGHRAQLLI 3154
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
L D+G Y CE G + ++I+ V + F L + ++ A L +
Sbjct: 3155 TGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGGA-ATLRCVLSSVAA 3213
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
V W +V+ +K++L + L++R D Y+C D TT + V
Sbjct: 3214 PVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD--QTTSATLTVTA 3271
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P + + R G+ TL + +A P EW S+ ++ D
Sbjct: 3272 LPAQFIGKLRNKEATEGATATLRCELSKAAPV---EWRKGSETLRDGDRYCLRQDGAMCE 3328
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
L I+ + DA Y CG ++TI P+
Sbjct: 3329 LQIRGLAMVDAAEYSC----VCGEERTSASLTIRPMPA 3362
Score = 131 bits (316), Expect = 3e-29
Identities = 147/691 (21%), Positives = 264/691 (38%), Gaps = 38/691 (5%)
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
E GT ++ +TWY++ + +S S + G LV+ + D+G+Y
Sbjct: 1547 EAGTSATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEA-GQADAGEYS 1605
Query: 906 CVASNSAGKSSHGARVTIDVEKVTFVKH--LQKSYETEEGKTVILECQTSHT-VSTKWYH 962
C AG + + KV F K + + E G + L C+ + WY
Sbjct: 1606 C----KAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYK 1661
Query: 963 NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRK 1022
+ K++S + G + G C Q+ S L V E P+ +
Sbjct: 1662 DGKKLSSSSKVRVEAVGCTRRLVVQQAGQAEAGEYSCEAGGQQLSFRLQVAELEPQISER 1721
Query: 1023 ---LQDFEVKEKDVAILEVEINSETA-DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRN 1078
+ VKE + IL + + +A V W +DG I+ K +++ +G L +
Sbjct: 1722 PCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSK-RHETASQGDTHTLTVHG 1780
Query: 1079 TSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR 1138
V D YSC + E V V E+ + L+ G T EL+ A V
Sbjct: 1781 AQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSPACAEVV 1840
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPS-IN 1197
W ++++ Q+ +G + L + +DAGEY CE + +A LTV P +
Sbjct: 1841 WRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVK 1900
Query: 1198 FTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRK 1257
F L + + V P + + V W++ ++++ +EKF + +L I
Sbjct: 1901 FMSGLSTVVAEEGGEATFQCVVSPSD-VAVVWFRDGALLQPSEKFAISQSGASHSLTISD 1959
Query: 1258 CTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQP 1317
+D + T A S+ L+V E P ++ S VTL V+ P P
Sbjct: 1960 LVLEDAGQITVEAEGASSSAALRVR--EAPVLFKKKLEPQTVEERSSVTLEVELTR-PWP 2016
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
W N+ + K+ + + L + V D G + ++ A + + +
Sbjct: 2017 ELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQ 2076
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQ 1437
+ E ++++ + + G+ T + +Q+ T ++V+ T
Sbjct: 2077 VRLVRGLQAVEAREQGTATMEVQLSHADVDGSWT--RDGLRFQQGPTCH-LAVRGPMHTL 2133
Query: 1438 TSIQNLKTNSS--YRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
T + L+ S F+A V+ T V+ E + + +PL+++ T
Sbjct: 2134 T-LSGLRPEDSGLMVFKAEGVH----------TSARLVVTELPV---SFSRPLQDVVTTE 2179
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAK 1526
E + L C P V W +DG +L+ K
Sbjct: 2180 KEKVTLECELSR-PNVDVRWLKDGVELRAGK 2209
Score = 126 bits (305), Expect = 7e-28
Identities = 122/542 (22%), Positives = 224/542 (41%), Gaps = 23/542 (4%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTL 805
G S LS +V + +TW K+ K + + + ++ G T + + + + D G Y+
Sbjct: 1549 GTSATLSCEVA-QAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQA-DAGEYSC 1606
Query: 806 KAENSEGIAETSAVITVEEPTEENA-EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
KA G S + V EP A E P +E+ + + L V + +
Sbjct: 1607 KA----GDQRLSFHLHVAEPKVVFAKEQPAH----REVQAEAGASATLSCEVAQAQT-EV 1657
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
TWY++ + +S S + G LV+ + ++G+Y C A + S +V
Sbjct: 1658 TWYKDGKKLSSSSKVRVEAVGCTRRLVVQQA-GQAEAGEYSCEAGGQ--QLSFRLQVAEL 1714
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXX 982
+++ ++ +E + +IL T + W + EI E +G
Sbjct: 1715 EPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTH 1774
Query: 983 XXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS 1042
D + C V + + V+E +F R L+ + L E++
Sbjct: 1775 TLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSP 1834
Query: 1043 ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
A+VVW ++ K ++ G +R L + D GEY C RD+ +A++TV
Sbjct: 1835 ACAEVVWRCGNTQLRVGK-RFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTV 1893
Query: 1103 -VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
V + ++ L +G +ATF+ ++ D V WF+DG+ +Q S ++ G
Sbjct: 1894 SVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASH 1953
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP 1221
L I D L+DAG+ + E + +A L V E + F +L E V + L VE+
Sbjct: 1954 SLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL-EPQTVEERSSVTLEVELT 2012
Query: 1222 DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
++ W + + + + + ++ + L++ D+ + C D K+ KL V
Sbjct: 2013 RPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTV 2072
Query: 1282 EV 1283
E+
Sbjct: 2073 EM 2074
Score = 122 bits (293), Expect = 2e-26
Identities = 206/1051 (19%), Positives = 385/1051 (36%), Gaps = 70/1051 (6%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
K P+ V G D + C +A+P + WL EE+V ++++ E H L I
Sbjct: 425 KLPRKTAVRVG-DTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRH----TLTI 479
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVRQGESVILSA 756
+ G +A G+ + K P Q ++P+ R SVILS
Sbjct: 480 SQCCLEDVGQVAFMA----GDCQTSTQFCVSAPRKPPLQPPVDPVVK--ARMESSVILSW 533
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT-ILKPK----KVKDEGVYTLKAENSE 811
+ +T K L T + H + P+ V +EG + +
Sbjct: 534 SPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALN 593
Query: 812 GIAETSAVITVEEPTEENAEPPLFINR-FQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
++ + E P + P L + + + E G + +T + W+ +
Sbjct: 594 SFGQSPYL---EFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLT--VASAGEWFLDG 648
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN--SAGKSSHGARVTIDVEKV 928
+ + S + D L I V + + K VA+ S+ + A + K
Sbjct: 649 QALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKP 708
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ E ++ E + + W + + +S E+
Sbjct: 709 PAAAAREVLARLHEEAQLLAEL-SDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRD 767
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQD---FEVKEKDVAILEVEINSETA 1045
D G+ +C+ + + L V + + F+ K + A E E +
Sbjct: 768 VARDDAGLYECVSRGGRIAYQLSV-QGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHV 826
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W +DG + ++ E G +L + DEG YSC + ++S + V E
Sbjct: 827 HVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSE- 885
Query: 1106 PPEII---TRLQNQKVNK--GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKK 1160
P+++ +L +K+ G AT E+ + V W+KDG ++ S+ + + G
Sbjct: 886 -PKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944
Query: 1161 QKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR--LPEFILVPANTDAYLTV 1218
++L + DAGEYSCE G + + L V+EP + F + A A L+
Sbjct: 945 RRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASATLSC 1004
Query: 1219 EIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK 1278
E+ +V WYK + + K + + +R L++++ + D +Y+C + + +
Sbjct: 1005 EVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFR 1064
Query: 1279 LKV-EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
L + E K E + + G+ L + A Q W + K +
Sbjct: 1065 LHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGME 1123
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
+ + L + + DAG Y G V ++ I + P G + + S
Sbjct: 1124 VKGCTRRLVLPQAGKADAGEYSC----EAGGQRVSFHLHITE---PKG---VFAKEQSVH 1173
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVN 1457
N + G + ++ V + + T + K ++ + +K + R V
Sbjct: 1174 N---EVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVK-GCTRRLVVQQVG 1229
Query: 1458 EVDISDASETTEYYKVIKETKIQSPTV----EKPLKN-ITTEPNEDIELTCIFGGVPQPK 1512
+ D + S +V + I P E+ + N + TE L+C Q +
Sbjct: 1230 KADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQA-QTE 1288
Query: 1513 VTWYRDGKKL-KTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
VTWY+DGKKL ++K E Y C A G S + +
Sbjct: 1289 VTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEA----GGQRLSFHLDVS 1344
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+ + + +K + + T E EV WYK+G KL + + + T
Sbjct: 1345 EPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCT 1404
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
+ +++ ++ + +Y+ EA + S++V
Sbjct: 1405 RRLVVQQACQADTGEYSCEAGGQRLSFSLDV 1435
Score = 122 bits (293), Expect = 2e-26
Identities = 150/720 (20%), Positives = 283/720 (39%), Gaps = 38/720 (5%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSV-LKITNVKKFQ 704
+ G+ L C VA + ++ W G+++ + V +E+ + C+ L + +
Sbjct: 1547 EAGTSATLSCE-VAQAQTEVTWYKDGKKL--SSSSKVRMEA---VGCTRRLVVQEAGQAD 1600
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G Y+ A ++ L + KE P E + G S LS +V +
Sbjct: 1601 AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEVA-QAQT 1655
Query: 765 TITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
+TW K+ K + + + ++ G T + + + + + G Y+ +A G + S +
Sbjct: 1656 EVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQA-EAGEYSCEA----GGQQLSFRLQ 1710
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
V E + +E P R + + VKE I L A + ++TW ++ I S+
Sbjct: 1711 VAELEPQISERPC---RREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHET 1767
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE 941
G+ L + +DS Y C G V ++ F + L+ E
Sbjct: 1768 ASQGDTHTLTVHGAQV-LDSAIYSC----RVGAEGQDFPVQVEEVAAKFCRLLEPVCG-E 1821
Query: 942 EGKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
G TV L C+ S + W ++ +++ EG D G C
Sbjct: 1822 LGGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCE 1881
Query: 1001 VKDQETSTMLVVK-ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPK 1059
+D TS L V + +F+ L +E A + ++ VVW RDG +++P
Sbjct: 1882 SRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPS 1941
Query: 1060 KNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVN 1119
+ K+ + G L I + + D G+ + S +A + V E P +L+ Q V
Sbjct: 1942 E-KFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVE 2000
Query: 1120 KGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE 1179
+ + T E+ELT+ +RW ++ + + ++++ +G + +L +++ D G + CE
Sbjct: 2001 ERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCE 2060
Query: 1180 VGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDT 1239
+ K A LTVE + L + + A + V++ +D +W + +
Sbjct: 2061 TPDDKTQAKLTVEMRQVRLVRGL-QAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQQG 2119
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKST-TKLKVEVVEFPPKIVDYEREYR 1298
L TL + +D ++ A+ T ++ V E P ++
Sbjct: 2120 PTCHLAVRGPMHTLTLSGLRPEDS---GLMVFKAEGVHTSARLVVTELPVSFSRPLQDVV 2176
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
VTL + P + W+ + ++ K + SLTI + E D G+Y
Sbjct: 2177 TTEKEKVTLECELSR-PNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVY 2235
Score = 115 bits (277), Expect = 2e-24
Identities = 136/655 (20%), Positives = 244/655 (37%), Gaps = 46/655 (7%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSIT 790
P PL+ ++ + E V L ++ P + W K+ ++A T + G S+T
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLECEL-SRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLT 2223
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAV----------ITVEEPTE-----ENAE---- 831
I + + D+GVY A +++ A + E+ E ENAE
Sbjct: 2224 IYRCE-FADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQ 2282
Query: 832 ------PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
P + ++ EK L +V+R + W++ ++ + P DG
Sbjct: 2283 LRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASA-QVRWFKGSQELQPGPKYELVSDG 2341
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+L+I++V +E D Y C AG A+ ++ + +T V+ LQ E
Sbjct: 2342 LYRKLIISDVHAE-DEDTYTC----DAGDVKTSAQFFVEEQSITIVRGLQ-DVTVMEPAP 2395
Query: 946 VILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
EC+TS KW K + + + QEG G + V
Sbjct: 2396 AWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGK 2455
Query: 1004 QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY 1063
+S LVV + R L+ +E +L + V W +D + P + K+
Sbjct: 2456 SRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQWYKDDTPLSPSE-KF 2514
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
G + +L I D G Y C + EVTV + LQ+ + +
Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEEGW 2574
Query: 1124 ATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
A+F EL+ D V W +G + + +++ G++ L + DAG
Sbjct: 2575 ASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKV 2634
Query: 1184 KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFT 1243
+A L V + F L + T A L E+ D V W K + ++K+
Sbjct: 2635 STSARLEVRVKPVVFLKALDDLSAEERGTLA-LQCEVSDPEAHVVWRKDGVQLGPSDKYD 2693
Query: 1244 LISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGS 1303
+ R L++ + +D YTC + T+ +V V + I + + G
Sbjct: 2694 FLHTAGTRGLVVHDVSPEDAGLYTCHV--GSEETRARVRVHDLHVGITKRLKTMEVLEGE 2751
Query: 1304 DVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAG 1356
+ ++ +++ P W V K + + + + L +++ +DAG
Sbjct: 2752 SCSFECVLSHESASDP-AMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAG 2805
Score = 105 bits (253), Expect = 1e-21
Identities = 83/355 (23%), Positives = 147/355 (41%), Gaps = 38/355 (10%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P+ AP+F+ +L+ + DG V F+C V G P P + WF+ +++ + +
Sbjct: 5117 PSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINE 5176
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDH--GSEMTVXXXXX 618
D L+I V P D G + C+A+N+ G +S+ EL V+ +D+ ++ T
Sbjct: 5177 DQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYF 5236
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL---------ECRLVAIPEPDIAWLF 669
+ EG T + Q V+E D+ + + ++ P P + W
Sbjct: 5237 SAQGYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFK 5296
Query: 670 KGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT 729
G+ + +I + + +H L+I +V + G Y N G A L ++
Sbjct: 5297 DGQPLTASAHIRMTDKKILH----TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRG 5352
Query: 730 GEKE-------------PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
++ PP+++E V++G S+ S +V G P PT+ W +
Sbjct: 5353 PDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERG 5412
Query: 777 AL---------PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
L S HS+ +L + + +G YT A N+ G A SA + V
Sbjct: 5413 VLWIGPDTPGYTVASSAQQHSLVLLDVGR-QHQGTYTCIASNAAGQALCSASLHV 5466
Score = 104 bits (250), Expect = 3e-21
Identities = 162/749 (21%), Positives = 289/749 (38%), Gaps = 66/749 (8%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+EG + +C +V+ + + W G + P E +++ H L I+++
Sbjct: 1911 EEGGEATFQC-VVSPSDVAVVWFRDGALLQPSEKFAISQSGASHS----LTISDLVLEDA 1965
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G TV A EG AS L+++ + P + L+ V + SV L ++ P P
Sbjct: 1966 GQITVEA---EG-ASSSAALRVR---EAPVLFKKKLEPQTVEERSSVTLEVELT-RPWPE 2017
Query: 766 ITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+ W +N P K + ++G H + +L D G + + + + T A +TV
Sbjct: 2018 LRWTRNATALAPGKNVEIHAEGARHRL-VLHNVGFADRGFFGCETPDDK----TQAKLTV 2072
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E + Q + +E+GT + +++ V +W R+ T
Sbjct: 2073 E------MRQVRLVRGLQAVEAREQGTATMEVQLSHADVDG-SWTRDGLRFQQGPTCHLA 2125
Query: 883 FDGENIELVITNVDSEIDSG-----------DYKCVASNSAGKSSHGAR--VTIDVEKVT 929
G L ++ + E DSG + V + S + VT + EKVT
Sbjct: 2126 VRGPMHTLTLSGLRPE-DSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVT 2184
Query: 930 F----------VKHLQKSYETEEGKTVILECQ---TSHTVSTKWYHNKKEI-----SGMD 971
V+ L+ E GKT+ + Q S T+ + ++
Sbjct: 2185 LECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQS 2244
Query: 972 HREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+ +GR D G I+ + ++ E+ L VKE +R L+D EK
Sbjct: 2245 SASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEK 2304
Query: 1032 DVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
+LE +++ +A V W + + ++P KY+ G RKL I + DE Y+C
Sbjct: 2305 HRGVLECQVSRASAQVRWFKGSQELQPGP-KYELVSDGLYRKLIISDVHAEDEDTYTCDA 2363
Query: 1092 RDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSN 1150
D +A+ V E I+ LQ+ V + A FE E + +W + +Q
Sbjct: 2364 GDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGG 2423
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPA 1210
++ L +G +L + G VG S+ +A L V + + T L E
Sbjct: 2424 NVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPL-EPKTGRE 2482
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
L+ + V WYK + + +EKF + + + L I + D Y C
Sbjct: 2483 LQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 2542
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
A S+T++ VE E + E + + + + ++ EW +N +
Sbjct: 2543 GSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYN 2599
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
+ S + +L +K ++ DAGI +
Sbjct: 2600 DSFHEISHKGRRHTLVLKSIQRADAGIVR 2628
Score = 98.3 bits (234), Expect = 3e-19
Identities = 119/564 (21%), Positives = 219/564 (38%), Gaps = 39/564 (6%)
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVK 798
++ V +G+ LS V G P+P W K+ + V + D + + + K
Sbjct: 245 RTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
D G+YT A N G +S ++ V EP A P F R Q++ V+EK + + V +
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLVVVREP----AVP--FKKRLQDLEVREKESATFLCEVPQ 358
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P W++ + S +G L + NV ++ D Y C ++ G
Sbjct: 359 -PSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSAD-DDAVYIC-------ETPEG 409
Query: 919 ARVTIDVE-KVTFVKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISGMDHREII 976
+R ++ + ++ L + G T + + + V W N++E+ I
Sbjct: 410 SRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAIS 469
Query: 977 QEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEK-DVAI 1035
EG DVG + + D +TST V ++ D VK + + ++
Sbjct: 470 AEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARMESSV 529
Query: 1036 LEVEINSETADVVWERDGEIIKPKK-NKYDF---EKRGHIRKLYIRNTSVHDEGEYSCIL 1091
+ + DG +++ KK Y + + + + V +EG + +
Sbjct: 530 ILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRV 589
Query: 1092 RDESCTAEVTVVELP------PEIITR--LQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ + +E P P++ R L+ + +G + TF ++LT A WF DG
Sbjct: 590 SALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASA-GEWFLDG 648
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
++ S+ ++ D + L I + G V N ++I + T P
Sbjct: 649 QALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKP 708
Query: 1204 -----EFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
+L + +A L E+ D+ VTW K + K+ + + +R L++R
Sbjct: 709 PAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDV 768
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVE 1282
DD Y CV + +L V+
Sbjct: 769 ARDDAGLYECVSRGGRIAYQLSVQ 792
Score = 89.4 bits (212), Expect = 1e-16
Identities = 108/524 (20%), Positives = 208/524 (39%), Gaps = 37/524 (7%)
Query: 1139 WFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEE 1193
W KDG + + H+ + LKI C D G Y+C VG + + ++ V E
Sbjct: 271 WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVRE 330
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
P++ F RL + + V A E+P + + W+K+++ + + K+ + + +R L
Sbjct: 331 PAVPFKKRLQD-LEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRL 389
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQA 1313
+R + DD Y C + T E+ + R+ ++ G V+ A
Sbjct: 390 TVRNVSADDDAVYICETPEGSRTV---AELAVQGNLLRKLPRKTAVRVGDTAMFCVEL-A 445
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P W+ N + + S + +LTI + D G + +C +
Sbjct: 446 VPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAF-MAGDC-QTSTQF 503
Query: 1374 NVTILDKP--SPPGKPNILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTTEWI-- 1428
V+ KP PP P + SS+ + W P + TI Y+VE +++ T WI
Sbjct: 504 CVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRC 563
Query: 1429 -SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP 1487
+ + + ++ ++ +++FR A+N S E + + +++P K
Sbjct: 564 HEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPL--KA 621
Query: 1488 LKNIT-TEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXX 1543
++ + E ++LT G W+ DG+ LK A + YE +R
Sbjct: 622 VQAVEGGEVTFSVDLTVASAG------EWFLDGQALK-ASSVYEIHCDRTRHTLTIREVP 674
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV----GDEWLVTAVIEGI 1599
+ F +G +E+S + ++ P +T + +V +E + A +
Sbjct: 675 ASLHGAQLKFVANG-IESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSD- 732
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY 1643
V W K+G L +Y + V+ ++++ R + Y
Sbjct: 733 QAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLY 776
Score = 81.4 bits (192), Expect = 3e-14
Identities = 54/209 (25%), Positives = 96/209 (45%), Gaps = 15/209 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F +PKA V G D L C++V P P ++W + + +A + D++
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYR--- 66
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT----GEKEPPQVIEPLKSMIVRQG 749
L I ++ G Y A N GEA + L++ E+ P ++ P S+ VR+G
Sbjct: 67 -LTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRP-TSIRVREG 124
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTHSITILKPKKVKDEGVYT 804
+V G+PRP ++W K+ + + + + G+ ++ I + + +D G Y
Sbjct: 125 SEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRI-RAARPRDGGTYE 183
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPP 833
++AEN G A +A + V+ + A P
Sbjct: 184 VRAENPLGAASAAAALVVDSDAADTASRP 212
Score = 81.0 bits (191), Expect = 4e-14
Identities = 90/392 (22%), Positives = 152/392 (38%), Gaps = 27/392 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVAT 567
AP F+ + +GS F C+V G PRP ++W + + ++ ++ +
Sbjct: 109 APHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASA 168
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
L IR P D GT+ A+N G AS+ L+V++ +D S +
Sbjct: 169 LRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRRE 228
Query: 628 IL--EGIPPT-FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
+ EG P + S + V EG L C + P+P+ W K ++V + V
Sbjct: 229 AMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWK-KDGQLVTEGRRHVVY 287
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + VLKI K+ G YT A N G+ +++ ++ E P + L+ +
Sbjct: 288 EDAQENF--VLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR--EPAVP-FKKRLQDL 342
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEG 801
VR+ ES + V P W K + A + +G +T+ + D+
Sbjct: 343 EVREKESATFLCE-VPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTV-RNVSADDDA 400
Query: 802 VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPV 861
VY E EG + T A + V+ + + T G + PV
Sbjct: 401 VYI--CETPEG-SRTVAELAVQGN---------LLRKLPRKTAVRVGDTAMFCVELAVPV 448
Query: 862 PSITWYRNNEIISPSETITQNFDGENIELVIT 893
+ W RN E + + + +G L I+
Sbjct: 449 GPVHWLRNQEEVVAGGRVAISAEGTRHTLTIS 480
Score = 78.6 bits (185), Expect = 2e-13
Identities = 55/195 (28%), Positives = 89/195 (45%), Gaps = 7/195 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P+ + K+ +V G+ LS Q+VGNP P ++W K+ +PV A DGD + +TI
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIK 851
L + D G Y +A N+ G A + + V+ + P F+ R I V+E
Sbjct: 70 L-DLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 852 LVARVTRNPVPSITWYRNNEIISPSETITQNFD--GENIELVITNVDSEIDSGDYKCVAS 909
RV +P P+++W ++ + + + GE L I D G Y+ A
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPR-DGGTYEVRAE 187
Query: 910 NSAGKSSHGARVTID 924
N G +S A + +D
Sbjct: 188 NPLGAASAAAALVVD 202
Score = 71.7 bits (168), Expect = 3e-11
Identities = 57/248 (22%), Positives = 106/248 (42%), Gaps = 8/248 (3%)
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI---LRDESCTAEVTV 1102
+ VW++DG+++ + +E L I D G Y+C L ++ ++ + V
Sbjct: 268 ETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVV 327
Query: 1103 VELPP-EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
V P RLQ+ +V + ATF E+ + WFK+ + + S + +G ++
Sbjct: 328 VREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTER 387
Query: 1162 KLKIYDCDLDDAGEYSCEV-GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+L + + DD Y CE S+ A L V+ N +LP V A VE+
Sbjct: 388 RLTVRNVSADDDAVYICETPEGSRTVAELAVQG---NLLRKLPRKTAVRVGDTAMFCVEL 444
Query: 1221 PDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLK 1280
V W + + + + + ++ + TL I +C +D + + D +++T+
Sbjct: 445 AVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFC 504
Query: 1281 VEVVEFPP 1288
V PP
Sbjct: 505 VSAPRKPP 512
Score = 70.5 bits (165), Expect = 6e-11
Identities = 60/207 (28%), Positives = 95/207 (45%), Gaps = 22/207 (10%)
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVI-LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDT- 786
T E + PQV+E L+ + V G + +V G P P + W K+ +P+ A D
Sbjct: 5254 TDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKK 5313
Query: 787 --HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV---EEPTEENAE-------PPL 834
H++ I+ + +D G Y N+ G A +SA + V +EP E+ A PP
Sbjct: 5314 ILHTLEIISVTR-EDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPR 5372
Query: 835 FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-----IISP-SETITQNFDGENI 888
+ RF VK+ +I +V PVP++ W R I P + T +
Sbjct: 5373 MLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQH 5432
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKS 915
LV+ +V + G Y C+ASN+AG++
Sbjct: 5433 SLVLLDVGRQ-HQGTYTCIASNAAGQA 5458
Score = 68.5 bits (160), Expect = 2e-10
Identities = 50/194 (25%), Positives = 79/194 (40%), Gaps = 11/194 (5%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK---SDGDTHSIT 790
PP E L GE+V L+ +V G P+P I+W K+ K V+ P D D
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
IL D G Y A ++ G T I V+ PP F+N+ + E
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ-------VPPRFVNKVRASPFVEGEDA 6125
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETI-TQNFDGENIELVITNVDSEIDSGDYKCVAS 909
+ + P P I WY++ +++ T + + +++ S+ D G Y+C
Sbjct: 6126 QFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELV 6185
Query: 910 NSAGKSSHGARVTI 923
N G + A + I
Sbjct: 6186 NRLGSARASAELRI 6199
Score = 68.1 bits (159), Expect = 3e-10
Identities = 33/96 (34%), Positives = 49/96 (51%), Gaps = 1/96 (1%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATL 568
P FV K+R +G QF C +EG P PQI W++ A++ FQ + + L
Sbjct: 6108 PRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVL 6167
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
VIR ED G + C N G A ++ EL +++P+
Sbjct: 6168 VIRAASKEDLGLYECELVNRLGSARASAELRIQSPM 6203
Score = 64.9 bits (151), Expect = 3e-09
Identities = 43/188 (22%), Positives = 76/188 (40%), Gaps = 9/188 (4%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK-----ATYENRXXXX 1536
P E+ L + T E E ++L C G P+P ++WY+DGK ++ +
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVI 1596
Y C A + G T + +Q P N+ G++ T I
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPP--RFVNKVRASPFVEGEDAQFTCTI 6131
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTS--VIRIKELKRSHSSKYTIEASNTAGTS 1654
EG P P++ WYK+G L ++ ++ ++ V+ I+ + Y E N G++
Sbjct: 6132 EGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSA 6191
Query: 1655 SVEVTLKV 1662
L++
Sbjct: 6192 RASAELRI 6199
Score = 61.3 bits (142), Expect = 4e-08
Identities = 57/221 (25%), Positives = 89/221 (40%), Gaps = 26/221 (11%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F+ + + G CQ+ G P PQ++W + + F++ D D +
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGD-LY 65
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
L I ++ D+G + C A+NA G A + L V+A + +E
Sbjct: 66 RLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAA--CAEQA-------------- 109
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
P F +P + V EGS+ CR+ P P ++W G + + V +E
Sbjct: 110 -------PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEE 162
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
S L+I + GTY V A N G AS L +
Sbjct: 163 LGE--ASALRIRAARPRDGGTYEVRAENPLGAASAAAALVV 201
Score = 60.1 bits (139), Expect = 9e-08
Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 7/156 (4%)
Query: 1597 EGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
E +P E WY NG ++ +D ++ +T + ++ + H+ + T + ++
Sbjct: 4457 EAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASAR 4516
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
+ V L + D P E V+ R S +VT+ W P+ DGG L Y +E E +W
Sbjct: 4517 LTV-LGLPDPPEDAE--VVAR--SSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRL 4571
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE 1751
++ E + L Y FRV A PVG E
Sbjct: 4572 CHELVPGPEC-VVDGLAPGETYRFRVAAVGPVGAGE 4606
Score = 59.3 bits (137), Expect = 1e-07
Identities = 50/213 (23%), Positives = 98/213 (46%), Gaps = 10/213 (4%)
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS--PSETITQNFDGENIE 889
PP F + T + T+KL RVT P P I+WY++ + + P + ++ DG +
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDG-SCA 6071
Query: 890 LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILE 949
L++ ++ +DSG Y C A+++AG S ++ + V FV ++ S EG+
Sbjct: 6072 LILDSLTG-VDSGQYMCFAASAAGNCSTLGKILVQVPP-RFVNKVRAS-PFVEGEDAQFT 6128
Query: 950 C--QTSHTVSTKWYHNKKEISGMDHREIIQEGRX--XXXXXXXXXXXDVGVIKCIVKDQE 1005
C + + +WY + ++ + + + E R D+G+ +C + ++
Sbjct: 6129 CTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRL 6188
Query: 1006 TSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
S + I + + Q+ +E+ VA +EV
Sbjct: 6189 GSARASAELRIQSPMLQAQEQCHREQLVAAVEV 6221
Score = 57.2 bits (132), Expect = 6e-07
Identities = 27/94 (28%), Positives = 48/94 (51%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F E+L G TV+ C+V G P+P I+W++ ++ + D D L+
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ + D+G + C A +AAG S+ +++V+ P
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVP 6107
Score = 55.2 bits (127), Expect = 2e-06
Identities = 43/197 (21%), Positives = 86/197 (43%), Gaps = 11/197 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F ++ + G + L CR+ P+P I+W G+ + D + + IE D C
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPH-HILIE-DPDGSC 6070
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+++ + ++ G Y A + G S + ++ PP+ + +++ +GE
Sbjct: 6071 ALI-LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQV----PPRFVNKVRASPFVEGEDA 6125
Query: 753 ILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTH-SITILKPKKVKDEGVYTLKAE 808
+ + G P P I W K+ + T S+ + + +++ +D G+Y +
Sbjct: 6126 QFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELV 6185
Query: 809 NSEGIAETSAVITVEEP 825
N G A SA + ++ P
Sbjct: 6186 NRLGSARASAELRIQSP 6202
Score = 54.4 bits (125), Expect = 4e-06
Identities = 30/119 (25%), Positives = 54/119 (45%), Gaps = 3/119 (2%)
Query: 815 ETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
ET A + EP + P+F+ Q V++ + VT P+PS+ W+++ +
Sbjct: 5105 ETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGK 5164
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
++ + N D + +I D G Y+C+A NS G SS A + +D+ +
Sbjct: 5165 LLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDY 5223
Score = 53.2 bits (122), Expect = 1e-05
Identities = 69/334 (20%), Positives = 125/334 (37%), Gaps = 24/334 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
+Q P+F G ++ EC V + W + + + + D
Sbjct: 4893 KQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDG 4952
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I + DAG +TC N G + + ++V GSE
Sbjct: 4953 TCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVVVS------GSESEAESSSGGELDDA 5006
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLEC-RLVAIPEPDIAW-LFKGEE---IVPDEN 679
+ F K A+ DE ++ L A PE W ++ +E + E
Sbjct: 5007 FRRAARRLHRLFRTKSPAEVSDE--ELFLSADEGPAEPEEPADWQTYREDEHFICIRFEA 5064
Query: 680 ISVA---IESDMHMYCSVLKITNVKKFQEGTYTV-VAVNREGEASL--PIVLKIKTGEKE 733
++ A + M+ ++ +K ++G V + +++E A + P L
Sbjct: 5065 LTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDA 5124
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHSI 789
P + L++ V+ G V V G P P++ W K+ K ++ + + H +
Sbjct: 5125 APVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
I+ D GVY AENS G++ T A + V+
Sbjct: 5185 -IITAVVPADMGVYRCLAENSMGVSSTKAELRVD 5217
Score = 48.8 bits (111), Expect = 2e-04
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 6/118 (5%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHE 1924
P P + V +S +VTL W P S+GG + Y +E K W V G E
Sbjct: 4523 PDPPEDAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGP--E 4580
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRL-EKHATVPSPPTAPLEIRMVGS 1980
++ + + FR++A VG P Q+VRL E VP P+AP E R V +
Sbjct: 4581 CVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-ESRQVAA 4637
Score = 46.8 bits (106), Expect = 9e-04
Identities = 35/155 (22%), Positives = 57/155 (36%), Gaps = 4/155 (2%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKR-TLIIRKCTEDDQCEYTCVLLDAKST-TKLKVEVV 1284
++WYK ++ LI D LI+ T D +Y C A + L +V
Sbjct: 6045 ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILV 6104
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA- 1343
+ PP+ V+ R G D + P P W + ++ + + +S
Sbjct: 6105 QVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL 6164
Query: 1344 -SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
L I+ D G+Y+ L N G A + I
Sbjct: 6165 LVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/180 (23%), Positives = 75/180 (41%), Gaps = 15/180 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F+ + + F V A L +I + T V WE+D + + ++ + G + +L
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGA-RFRLAQDGDLYRLT 68
Query: 1076 IRNTSVHDEGEYSCILRDE----------SCTAEVTVVELPPEIITRLQNQKVNKGNKAT 1125
I + ++ D G+Y C R+ AE E P + R + +V +G++AT
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 1126 FEIELTKGD-ALVRWFKDGSEIQFSNHIQLTID--GKKQKLKIYDCDLDDAGEYSCEVGN 1182
F + V W KDG + + ++ ++ G+ L+I D G Y N
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAEN 188
Score = 46.0 bits (104), Expect = 0.001
Identities = 48/203 (23%), Positives = 78/203 (38%), Gaps = 13/203 (6%)
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP+ L + G +T ++ W+KDG +Q H L D
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 1165 IYDCDLD-DAGEYSC----EVGN-SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
I D D+G+Y C GN S IL P +R F+ DA T
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFV---EGEDAQFTC 6129
Query: 1219 EIPDETL-DVTWYKKKSVIEDTEKFTLISDVKK--RTLIIRKCTEDDQCEYTCVLLDAKS 1275
I + WYK +++ KF +S+ + L+IR +++D Y C L++
Sbjct: 6130 TIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLG 6189
Query: 1276 TTKLKVEVVEFPPKIVDYEREYR 1298
+ + E+ P + E+ +R
Sbjct: 6190 SARASAELRIQSPMLQAQEQCHR 6212
Score = 45.6 bits (103), Expect = 0.002
Identities = 45/201 (22%), Positives = 81/201 (40%), Gaps = 15/201 (7%)
Query: 1200 LRLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
L P+ +V DA L+ +I + T V+W K + + +F L D L I
Sbjct: 13 LTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDL 72
Query: 1259 TEDDQCEYTC----VLLDAKSTTKLKVEV----VEFPPKIVDYEREYRIKRGSDVTLLVD 1310
D +Y C + +A + L+V+ E P + R++ GS+ T
Sbjct: 73 ALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCR 132
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPSID--SKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P+P W + + + + + ++ ++++L I+ D G Y++R EN G
Sbjct: 133 VGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGA 192
Query: 1369 ADVEMNVTI----LDKPSPPG 1385
A + + D S PG
Sbjct: 193 ASAAAALVVDSDAADTASRPG 213
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+ L PK + +V C P+ + W++ + PS+ F+M + +A L I
Sbjct: 2470 VLTRPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQ-MAELRI 2527
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+ P DAG + C AG A S+TE+ VEA
Sbjct: 2528 LRLMPADAGVYRC----QAGSAHSSTEVTVEA 2555
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/90 (30%), Positives = 41/90 (45%)
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
PE V A D L +E+ E +V W+K I+ +F ++S +++ L+I+ T +D
Sbjct: 4630 PESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAED 4689
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
Q EY C L V P VD
Sbjct: 4690 QGEYHCGLAQGSICPAAATFQVALSPASVD 4719
Score = 44.0 bits (99), Expect = 0.006
Identities = 27/95 (28%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 1092 RDESCTAEVTVVELPPEIITRLQNQKVNKGNK-ATFEIELTKGDALVR--WFKDGSEIQF 1148
R++ T T P+++ L++ +V G + A F++++ KG R WFKDG +
Sbjct: 5245 REQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKV-KGYPAPRLYWFKDGQPLTA 5303
Query: 1149 SNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
S HI++T L+I +D+G+Y+ + N+
Sbjct: 5304 SAHIRMTDKKILHTLEIISVTREDSGQYAAYISNA 5338
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 1031 KDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI 1090
+DV+ LE+E+ +E +V+W + E I+P +++ +G + L I+ + D+GEY C
Sbjct: 4639 EDVS-LELEVVAEAGEVIWHKGMERIQP-GGRFEVVSQGRQQMLVIKGFTAEDQGEYHCG 4696
Query: 1091 LRDES-CTAEVTV-VELPP 1107
L S C A T V L P
Sbjct: 4697 LAQGSICPAAATFQVALSP 4715
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 1965 VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTL 2024
+P PP E+ S+ V SW P DGG L GY + +++ W ++ V
Sbjct: 4522 LPDPPE-DAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHEL-VPGP 4579
Query: 2025 KFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
+ + L+ TY R+ A +G EP+
Sbjct: 4580 ECVVDGLAPGETYRFRVAAVGPVGAGEPV 4608
Score = 42.7 bits (96), Expect = 0.014
Identities = 28/80 (35%), Positives = 40/80 (50%), Gaps = 4/80 (5%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGK-KQKL 1163
P +T LQNQ+V G +F+ +T G + VRWFKDG ++ +H + D + +L
Sbjct: 5126 PVFLTELQNQEVQDGYPVSFDCVVT-GQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184
Query: 1164 KIYDCDLDDAGEYSCEVGNS 1183
I D G Y C NS
Sbjct: 5185 IITAVVPADMGVYRCLAENS 5204
Score = 42.3 bits (95), Expect = 0.018
Identities = 23/94 (24%), Positives = 42/94 (44%), Gaps = 1/94 (1%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVI 892
P F+ R + V L ++ NP P ++W ++ + ++ DG+ L I
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 893 TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
++ DSG Y C A N+ G++ + +D E
Sbjct: 70 LDLALG-DSGQYVCRARNAIGEAFAAVGLQVDAE 102
Score = 41.9 bits (94), Expect = 0.024
Identities = 41/187 (21%), Positives = 67/187 (35%), Gaps = 15/187 (8%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXX 1544
K +D L+C G P P+V+W +D + + A +
Sbjct: 17 KAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTILDLALGD 76
Query: 1545 XXXYKCIAFNDHGEVETSCVVGI-------QQKPVITISNEDIKQKHKVGDEWLVTAVIE 1597
Y C A N GE + + + +Q P + I+ + G E +
Sbjct: 77 SGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVRE--GSEATFRCRVG 134
Query: 1598 GIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
G P P V W K+G +L + +E + S +RI+ + Y + A N G +S
Sbjct: 135 GSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAAS 194
Query: 1656 VEVTLKV 1662
L V
Sbjct: 195 AAAALVV 201
Score = 41.9 bits (94), Expect = 0.024
Identities = 30/102 (29%), Positives = 38/102 (37%), Gaps = 2/102 (1%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
IL +PP F K +A EG D C + P P I W G + E
Sbjct: 6102 ILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPR 6161
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT 729
+ VL I K G Y VNR G A L+I++
Sbjct: 6162 SGLL--VLVIRAASKEDLGLYECELVNRLGSARASAELRIQS 6201
Score = 40.7 bits (91), Expect = 0.056
Identities = 23/81 (28%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-- 1653
++G P P + W+K+G L +T K+ + I + R S +Y SN G
Sbjct: 5284 VKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAY 5343
Query: 1654 SSVEVTLKVYDKP-SKPEGPV 1673
SS + ++ D+P KP V
Sbjct: 5344 SSARLLVRGPDEPEEKPASDV 5364
Score = 39.9 bits (89), Expect = 0.098
Identities = 23/78 (29%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +TR + V+ G AT ++ V W KD + +L DG +L I
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 1166 YDCDLDDAGEYSCEVGNS 1183
D L D+G+Y C N+
Sbjct: 70 LDLALGDSGQYVCRARNA 87
Score = 39.9 bits (89), Expect = 0.098
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 1582 QKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS-VIRIKELKRS 1638
Q +V D + V+ V+ G P P V W+K+G LE D Y I ++ + I + +
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKV 1662
Y A N+ G SS + L+V
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRV 5216
Score = 39.1 bits (87), Expect = 0.17
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F++ L + T+ +C+V P + W + + PS + + LV+
Sbjct: 2648 VFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTA-GTRGLVV 2705
Query: 571 REVFPEDAGTFTC 583
+V PEDAG +TC
Sbjct: 2706 HDVSPEDAGLYTC 2718
Score = 38.7 bits (86), Expect = 0.23
Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 509 API-FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
AP+ F+ +L+ + +G T C++ + W + + + P +QM D A
Sbjct: 3977 APVRFLRELQHQEVDEGGTAHLCCELSR-AGASVEWRKGSLQLFPCAKYQMV-QDGAAAE 4034
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFAS 593
L++R V EDAG +TC + AS
Sbjct: 4035 LLVRGVEQEDAGDYTCDTGHTQSMAS 4060
Score = 38.3 bits (85), Expect = 0.30
Identities = 38/182 (20%), Positives = 71/182 (39%), Gaps = 14/182 (7%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYEN---RXXXXXXXXXXX 1543
+ T + L+C G P+P+ W +DG+ + + YE+
Sbjct: 245 RTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPP- 1602
Y C A N G+ +S +V + ++P + Q +V ++ T + E +P P
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLV-VVREPAVPFKKR--LQDLEVREKESATFLCE-VPQPS 360
Query: 1603 -EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY---TIEASNTAGTSSVEV 1658
E W+K +L +Y I + + ++ + + Y T E S T +V+
Sbjct: 361 TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQG 420
Query: 1659 TL 1660
L
Sbjct: 421 NL 422
Score = 38.3 bits (85), Expect = 0.30
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1114 QNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDA 1173
++++V G + E+E+ V W K IQ ++ G++Q L I +D
Sbjct: 4631 ESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQ 4690
Query: 1174 GEYSCEVG-NSKCTAILTVE 1192
GEY C + S C A T +
Sbjct: 4691 GEYHCGLAQGSICPAAATFQ 4710
Score = 37.5 bits (83), Expect = 0.52
Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
++ + G P PE +W K+G + + + + ++ V++I K+S YT ASN
Sbjct: 257 LSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNL 316
Query: 1651 AGTSSVEVTLKVYDKPSKP 1669
G + V L V +P+ P
Sbjct: 317 VGQTYSSV-LVVVREPAVP 334
Score = 37.5 bits (83), Expect = 0.52
Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F+ L +G F+C V + WFR A+++PS+ F + + +L I
Sbjct: 1901 FMSGLSTVVAEEGGEATFQCVVSPSD-VAVVWFRDGALLQPSEKFAISQSGAS-HSLTIS 1958
Query: 572 EVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++ EDAG T A G +SS + EAP+
Sbjct: 1959 DLVLEDAGQITV---EAEGASSSAALRVREAPV 1988
Score = 37.5 bits (83), Expect = 0.52
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V+F C+V + W Q ++ ++ ++ D + TL ++ V PEDAGT +
Sbjct: 4176 VEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLG 4235
Query: 587 NAAGFASSTT---ELIVEAPLSD 606
N A A T E+ + PL D
Sbjct: 4236 NHASSAQLTVRAPEVTILEPLQD 4258
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 3/54 (5%)
Query: 1131 TKGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+K D RW KDG E+ +HI DG L I D DAG Y+C+V N
Sbjct: 4923 SKADVRARWLKDGVELTDGRHHHIDQLGDG-TCSLLITGLDRADAGCYTCQVSN 4975
Score = 35.1 bits (77), Expect = 2.8
Identities = 24/101 (23%), Positives = 44/101 (43%), Gaps = 2/101 (1%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTI-KLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E T + + P + +++ V + K +V P P + W+++ + ++ S I
Sbjct: 5251 ESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMT 5310
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
L I +V E DSG Y SN+ G + AR+ +
Sbjct: 5311 DKKILHTLEIISVTRE-DSGQYAAYISNAMGAAYSSARLLV 5350
Score = 34.7 bits (76), Expect = 3.7
Identities = 14/47 (29%), Positives = 22/47 (46%)
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
T +P L+N + + C+ G P P V W++DGK L+
Sbjct: 5121 TSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLE 5167
Score = 34.3 bits (75), Expect = 4.9
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 5/95 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+F E L+ +GST +C++ P + W + ++ + + A LV
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCELSE-PTATVVWSKGGLQLQANGRREPRLQGCT-AELV 3947
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++++ ED G +TC + A+S T + AP+
Sbjct: 3948 LQDLQREDTGEYTCTCGSQ---ATSATLTVTAAPV 3979
Score = 33.5 bits (73), Expect = 8.5
Identities = 34/172 (19%), Positives = 64/172 (37%), Gaps = 4/172 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VGD + + +P V W +N ++ I+ + + I + +
Sbjct: 433 RVGDTAMFCVEL-AVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVA 491
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLD-DGGLELTKYAI 1703
A + ++ V+ P PV+ + SV + W PP + + + Y +
Sbjct: 492 FMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARME-SSVILSWSPPPHGERPVTIDGYLV 550
Query: 1704 EKHEPDNNRWIKVADVD-RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE 1754
EK + WI+ + + + + E + FRV A N G S LE
Sbjct: 551 EKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLE 602
Score = 33.5 bits (73), Expect = 8.5
Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+T C+V P+ ++TW++ + S +M LV+++V DAG ++C
Sbjct: 1181 GTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGCT-RRLVVQQVGKADAGEYSC 1238
Query: 584 VA 585
A
Sbjct: 1239 EA 1240
Score = 33.5 bits (73), Expect = 8.5
Identities = 21/92 (22%), Positives = 40/92 (43%), Gaps = 3/92 (3%)
Query: 1781 NESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKX-XXXXXXXXARIQKLSINTTYQFR 1838
+ +V ++W +GG + Y+VE+K+ +W+ + L+ TY+FR
Sbjct: 4536 SHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFR 4595
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTP-PSQP 1869
+ A +G P + + + P P QP
Sbjct: 4596 VAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQP 4627
>AJ002535-1|CAC44768.1| 6620|Homo sapiens obscurin protein.
Length = 6620
Score = 192 bits (467), Expect = 2e-47
Identities = 166/673 (24%), Positives = 287/673 (42%), Gaps = 42/673 (6%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
++ +P F++ + + EG+ +L C L + + W KG E + D + + +
Sbjct: 3445 VKALPAKFTEGLRNEEAVEGATAMLWCELSKVAP--VEWR-KGPENLRDGDRYILRQEGT 3501
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y V A+L I P + IE +K+ R+
Sbjct: 3502 R--CE-LQICGLAMADAGEYLCVCGQERTSATLTI-------RALPARFIEDVKNQEARE 3551
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTL 805
G + +L ++ N + W K ++ ++ + DG + I + + D G Y+
Sbjct: 3552 GATAVLQCEL--NSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQI-RGLAMADTGEYSC 3608
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
G TSA++TV A P F + E T V R + + +
Sbjct: 3609 VC----GQERTSAMLTVR------ALPIKFTEGLRNEEATEGATA--VLRCELSKMAPVE 3656
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W++ +E + + + DG EL I + +E D+G+Y C+ GK A +T+
Sbjct: 3657 WWKGHETLRDGDRHSLRQDGARCELQIRGLVAE-DAGEYLCMC----GKERTSAMLTVRA 3711
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
F++ L+ E EG T L C+ S +W + + D + Q+G
Sbjct: 3712 MPSKFIEGLRNE-EATEGDTATLWCELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQ 3770
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G C+ + TS L V+ FI +++ E +E A+L+ E+ S+ A
Sbjct: 3771 IRGLAVVDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEAREGATAVLQCEL-SKAA 3829
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W + E ++ ++Y + G +L I SV D GEYSC+ E +A +TV
Sbjct: 3830 PVEWRKGSETLRGG-DRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAP 3888
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P LQ+ + +G+ AT + EL++ A V W K G ++Q + + + G +L +
Sbjct: 3889 QPVFREPLQSLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVL 3948
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
D +D GEY+C G+ +A LTV + F LR + V A+L E+
Sbjct: 3949 QDLQREDTGEYTCTCGSQATSATLTVTAAPVRF-LRELQHQEVDEGGTAHLCCELSRAGA 4007
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-- 1283
V W K + K+ ++ D L++R ++D +YTC +S L V V
Sbjct: 4008 SVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRVPR 4067
Query: 1284 VEFPPKIVDYERE 1296
+F ++ E+E
Sbjct: 4068 PKFKTRLQSLEQE 4080
Score = 188 bits (458), Expect = 2e-46
Identities = 270/1259 (21%), Positives = 487/1259 (38%), Gaps = 118/1259 (9%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F L+ T + V EC++ P + W + ++ + + + + R
Sbjct: 2168 FSRPLQDVVTTEKEKVTLECELSR-PNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYR 2226
Query: 572 EVFPEDAGTFTCVAKNAAGFAS-----STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
F D G + C A +A AS T LI L++ E+
Sbjct: 2227 CEFA-DQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLR- 2284
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
++ +P T + + + E +LEC+ V+ + W +E+ P + +
Sbjct: 2285 --VKELPVTLVRPLRDKIAMEKHRGVLECQ-VSRASAQVRWFKGSQELQPGPKYELVSDG 2341
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+Y ++ I++V E TYT A + + A + E++ ++ L+ + V
Sbjct: 2342 ---LYRKLI-ISDVHAEDEDTYTCDAGDVKTSAQFFV-------EEQSITIVRGLQDVTV 2390
Query: 747 RQGESVILSAQV-VGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGV 802
+ + + + RP W ++A + + +G H + + + V
Sbjct: 2391 MEPAPAWFECETSIPSVRPP-KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPV 2449
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ + G + +SA + V + P + + T +E ++ L P
Sbjct: 2450 HF-----TVGKSRSSARLVVSDI------PVVLTRPLEPKTGRELQSVVLSCDFRPAP-K 2497
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
++ WY+++ +SPSE + +G+ EL I + D+G Y+C AG + VT
Sbjct: 2498 AVQWYKDDTPLSPSEKFKMSLEGQMAELRILRL-MPADAGVYRC----QAGSAHSSTEVT 2552
Query: 923 IDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRX 981
++ +VT LQ + TEEG C+ SH +W N + EI +GR
Sbjct: 2553 VEAREVTVTGPLQDAEATEEG-WASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRR 2611
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
D G+++ TS L V+ F++ L D +E+ L+ E++
Sbjct: 2612 HTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVS 2671
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
A VVW +DG + P +KYDF R L + + S D G Y+C + E A V
Sbjct: 2672 DPEAHVVWRKDGVQLGPS-DKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVR 2730
Query: 1102 VVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGK 1159
V +L I RL+ +V +G +FE L+ A W G + S+ Q T G+
Sbjct: 2731 VHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGR 2790
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVE 1219
K L + + DAGE V A L V E L + + P D L E
Sbjct: 2791 KYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGE-DVELRCE 2849
Query: 1220 IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
+ V W K + I ++K+ ++ + L+IR + D EYTC + +KST L
Sbjct: 2850 LSRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASL 2909
Query: 1280 KVEVVE--FPPKIVDYEREYRIKRGSDV-TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
VE F ++ + + E ++G+ V T ++ P W ++ +P
Sbjct: 2910 HVEEKANCFTEELTNLQVE---EKGTAVFTCKTEH---PAATVTWRKGLLELRASGKHQP 2963
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS 1396
S + + LTI +E D+ Y + G A + + + + +I+E D
Sbjct: 2964 SQEGLTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGR-----RVHIIE-DLED 3013
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
+++ G+S + + W K T + N + +
Sbjct: 3014 VDV------QEGSSATFRCRISPANYEPVHWFLDK--TPLHANELNEIDAQPGGYHVLTL 3065
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTV-EKP------LKNITTEPNEDIELTCIFGGVP 1509
++ + D+ T Y++ + + V EKP L + T ED+ L C
Sbjct: 3066 RQLALKDSG--TIYFEAGDQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCETSTCD 3123
Query: 1510 QPKVTWYRDGKKLKTA---KATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV 1565
P + W +DGK L+ + + ++E +R YKC A G +S +V
Sbjct: 3124 IP-MCWTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIV 3178
Query: 1566 GIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
+ +PV E +K + G + V+ + P V W N L +Y++ +
Sbjct: 3179 RVHARPVRF--QEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQE 3235
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ ++ L+ S +Y S + G + TL V P++ G + +E +
Sbjct: 3236 GAMLELVVRNLRPQDSGRY----SCSFGDQTTSATLTVTALPAQFIGKLRNKEAT----- 3286
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
+G + + K P W K ++ RD + YC+++ CE R +A
Sbjct: 3287 --------EGATATLRCELSKTAPVE--WRKGSETLRDGDRYCLRQDGAMCELQIRGLA 3335
Score = 181 bits (440), Expect = 3e-44
Identities = 170/669 (25%), Positives = 276/669 (41%), Gaps = 39/669 (5%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVIL 754
L I+ ++K TYT + A L + + +IE L+ + V++G S
Sbjct: 2972 LTISALEKADSDTYTCDIGQAQSRAQLLV-------QGRRVHIIEDLEDVDVQEGSSATF 3024
Query: 755 SAQVVGNPRPTITWCKNNKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENS 810
++ + W + P+ A G H +T L+ +KD G +A
Sbjct: 3025 RCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLT-LRQLALKDSGTIYFEA--- 3080
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G SA + V E +P +F + T+ E + LV + +P + W ++
Sbjct: 3081 -GDQRASAALRVTE------KPSVFSRELTDATITEGEDLTLVCETSTCDIP-MCWTKDG 3132
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
+ + S + +G +L+IT + DSG YKC A + S V + V F
Sbjct: 3133 KTLRGSARCQLSHEGHRAQLLITGATLQ-DSGRYKCEAGGACSSSI----VRVHARPVRF 3187
Query: 931 VKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ L K E EG L C S + KW + + D + QEG
Sbjct: 3188 QEAL-KDLEVLEGGAATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNL 3246
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVW 1049
D G C DQ TS L V +FI KL++ E E A L E+ S+TA V W
Sbjct: 3247 RPQDSGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCEL-SKTAPVEW 3305
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEI 1109
+ E ++ ++Y + G + +L IR ++ D EYSC+ +E +A +T+ +P
Sbjct: 3306 RKGSETLRDG-DRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEERTSASLTIRPMPAHF 3364
Query: 1110 ITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
I RL++Q+ +G AT EL+K A V W K ++ + L DG +L+I
Sbjct: 3365 IGRLRHQESIEGATATLRCELSKA-APVEWRKGRESLRDGDRHSLRQDGAVCELQICGLA 3423
Query: 1170 LDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+ DAGEYSC G + +A LTV+ FT L V T A L E+ + V W
Sbjct: 3424 VADAGEYSCVCGEERTSATLTVKALPAKFTEGLRNEEAVEGAT-AMLWCEL-SKVAPVEW 3481
Query: 1230 YKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPK 1289
K + D +++ L + + L I D EY CV +++ L + + P +
Sbjct: 3482 RKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVCGQERTSATLTIRAL--PAR 3539
Query: 1290 IVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKK 1349
++ + + G+ L + + EW S+ ++ D L I+
Sbjct: 3540 FIEDVKNQEAREGATAVLQCELNSAAPV--EWRKGSETLRDGDRYSLRQDGTKCELQIRG 3597
Query: 1350 VENTDAGIY 1358
+ D G Y
Sbjct: 3598 LAMADTGEY 3606
Score = 171 bits (415), Expect = 3e-41
Identities = 196/889 (22%), Positives = 349/889 (39%), Gaps = 58/889 (6%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLV-AIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ +P F + K Q EG+ +L+C L A P + W E + + S+ +
Sbjct: 3797 VRALPARFIEDVKNQEAREGATAVLQCELSKAAP---VEWRKGSETLRGGDRYSLRQDGT 3853
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
C L+I + G Y+ V A+L + P EPL+S+
Sbjct: 3854 R---CE-LQIHGLSVADTGEYSCVCGQERTSATLTV-------RAPQPVFREPLQSLQAE 3902
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYT 804
+G + L ++ P T+ W K ++A + G T + +L+ + +D G YT
Sbjct: 3903 EGSTATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGCTAEL-VLQDLQREDTGEYT 3960
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P F+ Q V E GT L ++R S+
Sbjct: 3961 CTC----GSQATSATLTV------TAAPVRFLRELQHQEVDEGGTAHLCCELSRAGA-SV 4009
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + + + P DG EL++ V+ E D+GDY C G + A +++
Sbjct: 4010 EWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQE-DAGDYTC----DTGHTQSMASLSVR 4064
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHTVS---TKWYHNKKEISGMDHREIIQEGRX 981
V + F LQ S E E G L CQ S S +W E+ E+ +G
Sbjct: 4065 VPRPKFKTRLQ-SLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGAT 4123
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
D G C+ Q+T+ L V E +R L D EV + E++
Sbjct: 4124 RELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVS 4183
Query: 1042 SETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
A V W G ++ + + G I L ++ + D G S L + + +A++
Sbjct: 4184 RAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQL 4243
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTID-G 1158
TV I+ LQ+ ++++G A+F+ L++ RW G +Q + +T++ G
Sbjct: 4244 TVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQG 4303
Query: 1159 KKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
L ++ L+DAG S VG C++ ++ + N +R E + +A
Sbjct: 4304 TLHLLTLHKVTLEDAGTVSFHVGT--CSSEAQLKVTAKNTVVRGLENVEALEGGEALFEC 4361
Query: 1219 EIPD-ETLDVTWYKKKSVIEDTEKFTLI--SDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
++ E TW + +E ++ + + L+++ D C T + D +
Sbjct: 4362 QLSQPEVAAHTWLLDDEPVRTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAGDMVT 4421
Query: 1276 TTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHT 1334
+ L V +I++ + ++ G+ +A P W +N ++
Sbjct: 4422 SAFLTVRGWRL--EILEPLKNAAVRAGAQARFTCTLSEAVPVGEASWYINGAAVQPDDSD 4479
Query: 1335 -KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEID 1393
+ D +L ++ + AG + C A +T+L P PP ++
Sbjct: 4480 WTVTADGSHQALLLRSAQPHHAG----EVTFACRDAVASARLTVLGLPDPPEDAEVVAHS 4535
Query: 1394 SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFR 1452
S ++ + W P + G + Y VE +E T +W + + + + + L +YRFR
Sbjct: 4536 SHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFR 4595
Query: 1453 AYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIEL 1501
AV V + + ++ + K P P ++ ED+ L
Sbjct: 4596 VAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-ESRQVAAGEDVSL 4643
Score = 165 bits (401), Expect = 2e-39
Identities = 159/735 (21%), Positives = 292/735 (39%), Gaps = 46/735 (6%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ G+ +L C VA + ++ W G+++ + + ++ L + K
Sbjct: 1087 EAGASAMLSCE-VAQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRR----LVLPQAGKADA 1141
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G Y+ A + L I KE Q + + G + +LS +V P+
Sbjct: 1142 GEYSCEAGGQRVSFHLHITEPKGVFAKE--QSVH--NEVQAEAGTTAMLSCEVA-QPQTE 1196
Query: 766 ITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+TW K+ K + + + + G T + + + K D G Y+ +A G S + +
Sbjct: 1197 VTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKA-DAGEYSCEA----GGQRVSFQLHI 1251
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
EP A+ L N E+ + + L V + +TWY++ + +S S +
Sbjct: 1252 TEPKAVFAKEQLVHN---EVRTEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRIE 1307
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH--LQKSYET 940
G +LV+ + D+G+Y C AG + + K F K + +
Sbjct: 1308 AAGCMRQLVVQQA-GQADAGEYTC----EAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQA 1362
Query: 941 EEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
E G L C+ + WY + K++S + G D G C
Sbjct: 1363 EAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSC 1422
Query: 1000 IVKDQETSTMLVVKETIPEFIRKL---QDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
Q S L V E F ++ ++ + + L E+ +V+W +DG+ +
Sbjct: 1423 EAGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKL 1482
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQ-- 1114
+K E G R+L ++ D GEYSC + + + V E P + + Q
Sbjct: 1483 S-FSSKVRMEAVGCTRRLVVQQAGQADAGEYSCEAGSQRLSFHLHVAE-PKAVFAKEQPA 1540
Query: 1115 --NQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+ G AT E+ + V W+KDG ++ S+ +++ G ++L + + D
Sbjct: 1541 SREVQAEAGTSATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQAD 1600
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEF--ILVPANTDAYLTVEIPDETLDVTWY 1230
AGEYSC+ G+ + + L V EP + F P + A A L+ E+ +VTWY
Sbjct: 1601 AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWY 1660
Query: 1231 KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
K + + K + + R L++++ + D EY+C ++ V E P+I
Sbjct: 1661 KDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA--GGQRLSFRLHVAELEPQI 1718
Query: 1291 VD--YERE-YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
+ RE +K D+ L W+ + I++ K + + + +LT+
Sbjct: 1719 SERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTV 1778
Query: 1348 KKVENTDAGIYKLRL 1362
+ D+ IY R+
Sbjct: 1779 HGAQVLDSAIYSCRV 1793
Score = 163 bits (395), Expect = 8e-39
Identities = 201/904 (22%), Positives = 363/904 (40%), Gaps = 67/904 (7%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ +P F++ + + EG+ +L C L + + W +KG E + D + ++ D
Sbjct: 3621 VRALPIKFTEGLRNEEATEGATAVLRCELSKMAP--VEW-WKGHETLRDGDRH-SLRQD- 3675
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y + A L + P + IE L++ +
Sbjct: 3676 GARCE-LQIRGLVAEDAGEYLCMCGKERTSAMLTV-------RAMPSKFIEGLRNEEATE 3727
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKA 807
G++ L ++ + + W K ++ ++ DGD HS+ + +++ G+ + A
Sbjct: 3728 GDTATLWCEL--SKAAPVEWRKGHETLR------DGDRHSLRQDGSRCELQIRGLAVVDA 3779
Query: 808 ENSE---GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P FI + +E T L +++ +
Sbjct: 3780 GEYSCVCGQERTSATLTVR------ALPARFIEDVKNQEAREGATAVLQCELSK--AAPV 3831
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + +E + + + DG EL I + S D+G+Y CV G+ A +T+
Sbjct: 3832 EWRKGSETLRGGDRYSLRQDGTRCELQIHGL-SVADTGEYSCVC----GQERTSATLTVR 3886
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXX 983
+ F + LQ S + EEG T L+C+ S T + W ++ RE +G
Sbjct: 3887 APQPVFREPLQ-SLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAE 3945
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G C Q TS L V F+R+LQ EV E A L E++
Sbjct: 3946 LVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCCELSRA 4005
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
A V W + + P KY + G +L +R D G+Y+C A ++V
Sbjct: 4006 GASVEWRKGSLQLFPCA-KYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVR 4064
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
P+ TRLQ+ + G+ A +L+ + A+V+W K+G E+ ++ G +
Sbjct: 4065 VPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATR 4124
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP 1221
+L I+ + D GEY+C G K A L V EP + L + V A+ D + E+
Sbjct: 4125 ELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEVTIVRGLVD-AEVTADEDVEFSCEVS 4183
Query: 1222 DE-TLDVTWYKKKSVIEDTEKFTL-ISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
V W + ++ E + + D + TL ++ T +D + L + S+ +L
Sbjct: 4184 RAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQL 4243
Query: 1280 KVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
V E I++ ++ ++ G D + W + ++ + +++
Sbjct: 4244 TVRAPEV--TILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVE 4301
Query: 1340 SKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI--LEIDSSS 1396
+ LT+ KV DAG + C ++ ++ VT G N+ LE +
Sbjct: 4302 QGTLHLLTLHKVTLEDAGTVSFHV-GTCS-SEAQLKVT-AKNTVVRGLENVEALEGGEAL 4358
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
+PE + T + + + E + +N + ++NL+ S R A
Sbjct: 4359 FECQLSQPEVAAH-TWLLDDEPVRTSENAEVVFFENGLRHLLLLKNLRPQDSCRVTFLAG 4417
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFG-GVPQPKVTW 1515
+ V T + ++ +++ + +PLKN TC VP + +W
Sbjct: 4418 DMV--------TSAFLTVRGWRLE---ILEPLKNAAVRAGAQARFTCTLSEAVPVGEASW 4466
Query: 1516 YRDG 1519
Y +G
Sbjct: 4467 YING 4470
Score = 160 bits (389), Expect = 4e-38
Identities = 179/903 (19%), Positives = 341/903 (37%), Gaps = 56/903 (6%)
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
+DEG Y+ + G + V EP A+ L + Q E G ++
Sbjct: 863 QDEGTYSCRV----GEDSVDFRLRVSEPKVVFAKEQLARRKLQA----EAGASATLSCEV 914
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
+TWY++ + +S S + G LV+ + D+G+Y C AG
Sbjct: 915 AQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQA-GQADAGEYSC----EAGGQRL 969
Query: 918 GARVTIDVEKVTFVKH--LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHRE 974
+ + KV F K + E G L C+ + WY + K++S
Sbjct: 970 SFHLDVKEPKVVFAKDQVAHSEVQAEAGANATLSCEVAQAQAEVMWYKDGKKLSSSLKVH 1029
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKL---QDFEVKEK 1031
+ +G D G C + Q S L + E F ++ + + +
Sbjct: 1030 VEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAG 1089
Query: 1032 DVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
A+L E+ +V W +DG+ + +K E +G R+L + D GEYSC
Sbjct: 1090 ASAMLSCEVAQAQTEVTWYKDGKKLS-SSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA 1148
Query: 1092 RDESCTAEVTVVELPPEIITRLQN----QKVNKGNKATFEIELTKGDALVRWFKDGSEIQ 1147
+ + + + E P + + Q+ + G A E+ + V W+KDG ++
Sbjct: 1149 GGQRVSFHLHITE-PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLS 1207
Query: 1148 FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR--LPEF 1205
S+ +++ + G ++L + DAGEYSCE G + + L + EP F +
Sbjct: 1208 SSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNE 1267
Query: 1206 ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
+ A A L+ E+ +VTWYK + + K + + R L++++ + D E
Sbjct: 1268 VRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327
Query: 1266 YTCVLLDAKSTTKLKV-EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
YTC + + L V E K R+ + + G+ TL + A Q W +
Sbjct: 1328 YTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEV-AQAQTEVTWYKD 1386
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL--ENNCGHADVEMNVTILDKPS 1382
K + + + L +++ D G Y + DV + K
Sbjct: 1387 GKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQ 1446
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
P + + +S+ C E T + + + +++ + + ++ + T+ +
Sbjct: 1447 PVHREVQAQAGASTTLSC----EVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQ 1502
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
+ E S+ ++ + E K + + + E L+
Sbjct: 1503 QAGQAD-------AGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLS 1555
Query: 1503 CIFGGVPQPKVTWYRDGKKL-KTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
C Q +VTWY+DGKKL ++K E Y C A G+
Sbjct: 1556 CEVAQA-QTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKA----GD 1610
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDK 1617
S + + + V+ + ++ + T E EV WYK+G KL +
Sbjct: 1611 QRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSS 1670
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASN---TAGTSSVEVTLKVYDKPSKPEGPVI 1674
+ + T + +++ ++ + +Y+ EA + E+ ++ ++P + E P++
Sbjct: 1671 KVRVEAVGCTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHVAELEPQISERPCRRE-PLV 1729
Query: 1675 MRE 1677
++E
Sbjct: 1730 VKE 1732
Score = 148 bits (359), Expect = 2e-34
Identities = 142/641 (22%), Positives = 257/641 (40%), Gaps = 32/641 (4%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ G+ L C VA + ++ W G+++ + V L + +
Sbjct: 1639 EAGASATLSCE-VAQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRR----LVVQQAGQADA 1693
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G Y+ A + L + +++ E P EPL +V++ E +IL+A + T
Sbjct: 1694 GEYSCEAGGQRLSFRLHVA-ELEPQISERPCRREPL---VVKEHEDIILTATLATPSAAT 1749
Query: 766 ITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+TW K+ + K T S GDTH++T+ +V D +Y+ + +EG + V
Sbjct: 1750 VTWLKDGVEIRRSKRHETASQGDTHTLTV-HGAQVLDSAIYSCRV-GAEG---QDFPVQV 1804
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
EE + F + + + GT+ L ++ + W N +
Sbjct: 1805 EEVAAK------FCRLLEPVCGELGGTVTLACELSP-ACAEVVWRCGNTQPRVGKRFQMV 1857
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
+G L + + +E D+G+Y C + + A++T+ V +V + EE
Sbjct: 1858 AEGPVRSLTVLGLRAE-DAGEYVCESRDD----HTSAQLTVSVPRVVKFMSGLSTVVAEE 1912
Query: 943 GKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
G +C S + V+ W+ + + + I Q G D G I
Sbjct: 1913 GGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEA 1972
Query: 1002 KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKN 1061
+ +S L V+E F +KL+ V+E+ LEVE+ ++ W R+ + P KN
Sbjct: 1973 EGASSSAALRVREAPVLFKKKLEPQTVEERSSVTLEVELTRPWPELRWTRNATALAPGKN 2032
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKG 1121
+ G +L + N D G + C D+ A++TV ++ LQ + +
Sbjct: 2033 -VEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQ 2091
Query: 1122 NKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG 1181
AT E++L+ D W +DG Q L + G L + +D+G +
Sbjct: 2092 GTATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAE 2151
Query: 1182 NSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEK 1241
+A L V E ++F+ L + ++ L E+ +DV W K + +
Sbjct: 2152 GVHTSARLVVTELPVSFSRPLQD-VVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKT 2210
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
+ + R+L I +C DQ Y C DA+S+ +KV+
Sbjct: 2211 MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQ 2251
Score = 141 bits (342), Expect = 2e-32
Identities = 136/567 (23%), Positives = 236/567 (41%), Gaps = 35/567 (6%)
Query: 632 IPPTFSKKP---KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ P S++P + V E DI+L L + WL G EI + A + D
Sbjct: 1714 LEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDT 1773
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
H L + + Y+ V EG+ P+ +++ + +++EP+ +
Sbjct: 1774 H----TLTVHGAQVLDSAIYSC-RVGAEGQ-DFPV--QVEEVAAKFCRLLEPVCGEL--- 1822
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPV--KALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G +V L+ ++ + C N +P K ++G S+T+L + +D G Y +
Sbjct: 1823 GGTVTLACELSPACAEVVWRCGNTQPRVGKRFQMVAEGPVRSLTVLG-LRAEDAGEYVCE 1881
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
+ + TSA +TV P F++ + +E G V+ + V ++ W
Sbjct: 1882 SRDDH----TSAQLTVSVPRVVK-----FMSGLSTVVAEEGGEATFQCVVSPSDV-AVVW 1931
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+R+ ++ PSE + G + L I+++ E D+G + + G SS A + +
Sbjct: 1932 FRDGALLQPSEKFAISQSGASHSLTISDLVLE-DAGQ---ITVEAEGASSSAA-LRVREA 1986
Query: 927 KVTFVKHLQKSYETEEGKTVILECQ-TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
V F K L+ EE +V LE + T +W N ++ + EI EG
Sbjct: 1987 PVLFKKKLEPQ-TVEERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLV 2045
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G C D +T L V+ +R LQ E +E+ A +EV+++
Sbjct: 2046 LHNVGFADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQLSHADV 2105
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
D W RDG + + RG + L + D G +A + V EL
Sbjct: 2106 DGSWTRDGLRFQQGPTCH-LAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTEL 2164
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P LQ+ + K T E EL++ + VRW KDG E++ + + G + L I
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTI 2224
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVE 1192
Y C+ D G Y C+ +++ +A + V+
Sbjct: 2225 YRCEFADQGVYVCDAHDAQSSASVKVQ 2251
Score = 132 bits (320), Expect = 1e-29
Identities = 161/757 (21%), Positives = 282/757 (37%), Gaps = 47/757 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P F K +E + L+C V+ PE + W G ++ P + +
Sbjct: 2646 PVVFLKALDDLSAEERGTLALQCE-VSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRG-- 2702
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L + +V G YT + E A + V + G + + LK+M V +GES
Sbjct: 2703 --LVVHDVSPEDAGLYTCHVGSEETRARVR-VHDLHVG------ITKRLKTMEVLEGESC 2753
Query: 753 ----ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
+LS + +P K G + I +++ D G
Sbjct: 2754 SFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKY-ILVVREAAPSDAGEVVFSVR 2812
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
G+ +++I E P I ++ V ++L ++R P + W +
Sbjct: 2813 ---GLTSKASLIVRERPAA-------IIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLK 2861
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
+ + I S+ +G LVI + D+G+Y C A KS+ A + ++ +
Sbjct: 2862 DRKAIRKSQKYDVVCEGTMAMLVIRGASLK-DAGEYTCEVE--ASKST--ASLHVEEKAN 2916
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVST-KWYHNKKEISGMDHREIIQEGRXXXXXXX 987
F + L + + EE T + C+T H +T W E+ + QEG
Sbjct: 2917 CFTEELT-NLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTIS 2975
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADV 1047
D C + ++ L+V+ I L+D +V+E A I+ +
Sbjct: 2976 ALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEP 3035
Query: 1048 V-WERDGEIIKPKK-NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W D + + N+ D + G+ L +R ++ D G D+ +A + V E
Sbjct: 3036 VHWFLDKTPLHANELNEIDAQPGGY-HVLTLRQLALKDSGTIYFEAGDQRASAALRVTEK 3094
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P L + + +G T E + D + W KDG ++ S QL+ +G + +L I
Sbjct: 3095 PSVFSRELTDATITEGEDLTLVCETSTCDIPMCWTKDGKTLRGSARCQLSHEGHRAQLLI 3154
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
L D+G Y CE G + ++I+ V + F L + ++ A L +
Sbjct: 3155 TGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGGA-ATLRCVLSSVAA 3213
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
V W +V+ +K++L + L++R D Y+C D TT + V
Sbjct: 3214 PVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGD--QTTSATLTVTA 3271
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
P + + R G+ TL + EW S+ ++ D L
Sbjct: 3272 LPAQFIGKLRNKEATEGATATLRCELSKTAPV--EWRKGSETLRDGDRYCLRQDGAMCEL 3329
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
I+ + DA Y CG ++TI P+
Sbjct: 3330 QIRGLAMVDAAEYSC----VCGEERTSASLTIRPMPA 3362
Score = 128 bits (310), Expect = 2e-28
Identities = 141/643 (21%), Positives = 256/643 (39%), Gaps = 32/643 (4%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G+ L C VA + ++ W G+++ + S + + L + + G
Sbjct: 1457 GASTTLSCE-VAQAQTEVMWYKDGKKL----SFSSKVRMEAVGCTRRLVVQQAGQADAGE 1511
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
Y+ A ++ L + KE P E + G S LS +V + +T
Sbjct: 1512 YSCEAGSQRLSFHLHVAEPKAVFAKEQPASRE----VQAEAGTSATLSCEVA-QAQTEVT 1566
Query: 768 WCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
W K+ K + + + ++ G T + + + + D G Y+ KA G S + V E
Sbjct: 1567 WYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQA-DAGEYSCKA----GDQRLSFHLHVAE 1621
Query: 825 PTEENA-EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
P A E P +E+ + + L V + +TWY++ + +S S +
Sbjct: 1622 PKVVFAKEQPAH----REVQAEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRVEA 1676
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
G LV+ + D+G+Y C A + S V +++ ++ +E
Sbjct: 1677 VGCTRRLVVQQA-GQADAGEYSCEAGGQ--RLSFRLHVAELEPQISERPCRREPLVVKEH 1733
Query: 944 KTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
+ +IL T + W + EI E +G D + C V
Sbjct: 1734 EDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRV 1793
Query: 1002 KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKN 1061
+ + V+E +F R L+ + L E++ A+VVW R G
Sbjct: 1794 GAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSPACAEVVW-RCGNTQPRVGK 1852
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV-VELPPEIITRLQNQKVNK 1120
++ G +R L + D GEY C RD+ +A++TV V + ++ L +
Sbjct: 1853 RFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVKFMSGLSTVVAEE 1912
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
G +ATF+ ++ D V WF+DG+ +Q S ++ G L I D L+DAG+ + E
Sbjct: 1913 GGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEA 1972
Query: 1181 GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE 1240
+ +A L V E + F +L E V + L VE+ ++ W + + + +
Sbjct: 1973 EGASSSAALRVREAPVLFKKKL-EPQTVEERSSVTLEVELTRPWPELRWTRNATALAPGK 2031
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV 1283
+ ++ + L++ D+ + C D K+ KL VE+
Sbjct: 2032 NVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTVEM 2074
Score = 122 bits (293), Expect = 2e-26
Identities = 206/1051 (19%), Positives = 386/1051 (36%), Gaps = 70/1051 (6%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
K P+ V G D + C +A+P + WL EE+V ++++ E H L I
Sbjct: 425 KLPRKTAVRVG-DTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRH----TLTI 479
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVRQGESVILSA 756
+ G +A G+ + K P Q ++P+ R SVILS
Sbjct: 480 SQCCLEDVGQVAFMA----GDCQTSTRFCVSAPRKPPLQPPVDPVVK--ARMESSVILSW 533
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT-ILKPK----KVKDEGVYTLKAENSE 811
+ +T K L T + H + P+ V +EG + +
Sbjct: 534 SPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALN 593
Query: 812 GIAETSAVITVEEPTEENAEPPLFINR-FQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
++ + E P + P L + + + E G + +T + W+ +
Sbjct: 594 SFGQSPYL---EFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLT--VASAGEWFLDG 648
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN--SAGKSSHGARVTIDVEKV 928
+ + S + D L I V + + K VA+ S+ + A + K
Sbjct: 649 QALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKP 708
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ E ++ E + + W + + +S E+
Sbjct: 709 PAAAAREVLARLHEEAQLLAEL-SDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRD 767
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQD---FEVKEKDVAILEVEINSETA 1045
D G+ +C+ + + L V + + F+ K + A E E +
Sbjct: 768 VARDDAGLYECVSRGGRIAYQLSV-QGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHV 826
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W +DG + ++ E G +L + DEG YSC + ++S + V E
Sbjct: 827 HVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSE- 885
Query: 1106 PPEII---TRLQNQKVNK--GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKK 1160
P+++ +L +K+ G AT E+ + V W+KDG ++ S+ + + G
Sbjct: 886 -PKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCT 944
Query: 1161 QKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR--LPEFILVPANTDAYLTV 1218
++L + DAGEYSCE G + + L V+EP + F + A +A L+
Sbjct: 945 RRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGANATLSC 1004
Query: 1219 EIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK 1278
E+ +V WYK + + K + + +R L++++ + D +Y+C + + +
Sbjct: 1005 EVAQAQAEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFR 1064
Query: 1279 LKV-EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
L + E K E + + G+ L + A Q W + K +
Sbjct: 1065 LHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKLSSSSKVGME 1123
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSI 1397
+ + L + + DAG Y G V ++ I + P G + + S
Sbjct: 1124 VKGCTRRLVLPQAGKADAGEYSC----EAGGQRVSFHLHITE---PKG---VFAKEQSVH 1173
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVN 1457
N + G + ++ V + + T + K ++ + +K + R V
Sbjct: 1174 N---EVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVK-GCTRRLVVQQVG 1229
Query: 1458 EVDISDASETTEYYKVIKETKIQSPTV----EKPLKN-ITTEPNEDIELTCIFGGVPQPK 1512
+ D + S +V + I P E+ + N + TE L+C Q +
Sbjct: 1230 KADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQA-QTE 1288
Query: 1513 VTWYRDGKKL-KTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
VTWY+DGKKL ++K E Y C A G S + +
Sbjct: 1289 VTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEA----GGQRLSFHLDVS 1344
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+ + + +K + + T E EV WYK+G KL + + + T
Sbjct: 1345 EPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCT 1404
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
+ +++ ++ + +Y+ EA + S++V
Sbjct: 1405 RRLVVQQACQADTGEYSCEAGGQRLSFSLDV 1435
Score = 120 bits (289), Expect = 6e-26
Identities = 151/720 (20%), Positives = 281/720 (39%), Gaps = 38/720 (5%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSV-LKITNVKKFQ 704
+ G+ L C VA + ++ W G+++ + V +E+ + C+ L + +
Sbjct: 1547 EAGTSATLSCE-VAQAQTEVTWYKDGKKL--SSSSKVRMEA---VGCTRRLVVQEAGQAD 1600
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
G Y+ A ++ L + KE P E + G S LS +V +
Sbjct: 1601 AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHRE----VQAEAGASATLSCEVA-QAQT 1655
Query: 765 TITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
+TW K+ K + + + ++ G T + + + + D G Y+ +A G S +
Sbjct: 1656 EVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQA-DAGEYSCEA----GGQRLSFRLH 1710
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
V E + +E P R + + VKE I L A + ++TW ++ I S+
Sbjct: 1711 VAELEPQISERPC---RREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHET 1767
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE 941
G+ L + +DS Y C G V ++ F + L+ E
Sbjct: 1768 ASQGDTHTLTVHGAQV-LDSAIYSC----RVGAEGQDFPVQVEEVAAKFCRLLEPVCG-E 1821
Query: 942 EGKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
G TV L C+ S + W + +++ EG D G C
Sbjct: 1822 LGGTVTLACELSPACAEVVWRCGNTQPRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCE 1881
Query: 1001 VKDQETSTMLVVK-ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPK 1059
+D TS L V + +F+ L +E A + ++ VVW RDG +++P
Sbjct: 1882 SRDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPS 1941
Query: 1060 KNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVN 1119
+ K+ + G L I + + D G+ + S +A + V E P +L+ Q V
Sbjct: 1942 E-KFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVE 2000
Query: 1120 KGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE 1179
+ + T E+ELT+ +RW ++ + + ++++ +G + +L +++ D G + CE
Sbjct: 2001 ERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCE 2060
Query: 1180 VGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDT 1239
+ K A LTVE + L + + A + V++ +D +W + +
Sbjct: 2061 TPDDKTQAKLTVEMRQVRLVRGL-QAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQQG 2119
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKST-TKLKVEVVEFPPKIVDYEREYR 1298
L TL + +D ++ A+ T ++ V E P ++
Sbjct: 2120 PTCHLAVRGPMHTLTLSGLRPEDS---GLMVFKAEGVHTSARLVVTELPVSFSRPLQDVV 2176
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
VTL + P + W+ + ++ K + SLTI + E D G+Y
Sbjct: 2177 TTEKEKVTLECELSR-PNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVY 2235
Score = 115 bits (277), Expect = 2e-24
Identities = 136/655 (20%), Positives = 244/655 (37%), Gaps = 46/655 (7%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSIT 790
P PL+ ++ + E V L ++ P + W K+ ++A T + G S+T
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLECEL-SRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLT 2223
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAV----------ITVEEPTE-----ENAE---- 831
I + + D+GVY A +++ A + E+ E ENAE
Sbjct: 2224 IYRCE-FADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQ 2282
Query: 832 ------PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
P + ++ EK L +V+R + W++ ++ + P DG
Sbjct: 2283 LRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASA-QVRWFKGSQELQPGPKYELVSDG 2341
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+L+I++V +E D Y C AG A+ ++ + +T V+ LQ E
Sbjct: 2342 LYRKLIISDVHAE-DEDTYTC----DAGDVKTSAQFFVEEQSITIVRGLQ-DVTVMEPAP 2395
Query: 946 VILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
EC+TS KW K + + + QEG G + V
Sbjct: 2396 AWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGK 2455
Query: 1004 QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY 1063
+S LVV + R L+ +E +L + V W +D + P + K+
Sbjct: 2456 SRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQWYKDDTPLSPSE-KF 2514
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
G + +L I D G Y C + EVTV + LQ+ + +
Sbjct: 2515 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEEGW 2574
Query: 1124 ATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
A+F EL+ D V W +G + + +++ G++ L + DAG
Sbjct: 2575 ASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKV 2634
Query: 1184 KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFT 1243
+A L V + F L + T A L E+ D V W K + ++K+
Sbjct: 2635 STSARLEVRVKPVVFLKALDDLSAEERGTLA-LQCEVSDPEAHVVWRKDGVQLGPSDKYD 2693
Query: 1244 LISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGS 1303
+ R L++ + +D YTC + T+ +V V + I + + G
Sbjct: 2694 FLHTAGTRGLVVHDVSPEDAGLYTCHV--GSEETRARVRVHDLHVGITKRLKTMEVLEGE 2751
Query: 1304 DVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAG 1356
+ ++ +++ P W V K + + + + L +++ +DAG
Sbjct: 2752 SCSFECVLSHESASDP-AMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAG 2805
Score = 105 bits (253), Expect = 1e-21
Identities = 83/355 (23%), Positives = 147/355 (41%), Gaps = 38/355 (10%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P+ AP+F+ +L+ + DG V F+C V G P P + WF+ +++ + +
Sbjct: 5117 PSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINE 5176
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDH--GSEMTVXXXXX 618
D L+I V P D G + C+A+N+ G +S+ EL V+ +D+ ++ T
Sbjct: 5177 DQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYF 5236
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILL---------ECRLVAIPEPDIAWLF 669
+ EG T + Q V+E D+ + + ++ P P + W
Sbjct: 5237 SAQGYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFK 5296
Query: 670 KGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT 729
G+ + +I + + +H L+I +V + G Y N G A L ++
Sbjct: 5297 DGQPLTASAHIRMTDKKILH----TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRG 5352
Query: 730 GEKE-------------PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK 776
++ PP+++E V++G S+ S +V G P PT+ W +
Sbjct: 5353 PDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERG 5412
Query: 777 AL---------PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
L S HS+ +L + + +G YT A N+ G A SA + V
Sbjct: 5413 VLWIGPDTPGYTVASSAQQHSLVLLDVGR-QHQGTYTCIASNAAGQALCSASLHV 5466
Score = 104 bits (250), Expect = 3e-21
Identities = 162/749 (21%), Positives = 289/749 (38%), Gaps = 66/749 (8%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+EG + +C +V+ + + W G + P E +++ H L I+++
Sbjct: 1911 EEGGEATFQC-VVSPSDVAVVWFRDGALLQPSEKFAISQSGASHS----LTISDLVLEDA 1965
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G TV A EG AS L+++ + P + L+ V + SV L ++ P P
Sbjct: 1966 GQITVEA---EG-ASSSAALRVR---EAPVLFKKKLEPQTVEERSSVTLEVELT-RPWPE 2017
Query: 766 ITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+ W +N P K + ++G H + +L D G + + + + T A +TV
Sbjct: 2018 LRWTRNATALAPGKNVEIHAEGARHRL-VLHNVGFADRGFFGCETPDDK----TQAKLTV 2072
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E + Q + +E+GT + +++ V +W R+ T
Sbjct: 2073 E------MRQVRLVRGLQAVEAREQGTATMEVQLSHADVDG-SWTRDGLRFQQGPTCHLA 2125
Query: 883 FDGENIELVITNVDSEIDSG-----------DYKCVASNSAGKSSHGAR--VTIDVEKVT 929
G L ++ + E DSG + V + S + VT + EKVT
Sbjct: 2126 VRGPMHTLTLSGLRPE-DSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVT 2184
Query: 930 F----------VKHLQKSYETEEGKTVILECQ---TSHTVSTKWYHNKKEI-----SGMD 971
V+ L+ E GKT+ + Q S T+ + ++
Sbjct: 2185 LECELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQS 2244
Query: 972 HREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEK 1031
+ +GR D G I+ + ++ E+ L VKE +R L+D EK
Sbjct: 2245 SASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEK 2304
Query: 1032 DVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
+LE +++ +A V W + + ++P KY+ G RKL I + DE Y+C
Sbjct: 2305 HRGVLECQVSRASAQVRWFKGSQELQPGP-KYELVSDGLYRKLIISDVHAEDEDTYTCDA 2363
Query: 1092 RDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSN 1150
D +A+ V E I+ LQ+ V + A FE E + +W + +Q
Sbjct: 2364 GDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGG 2423
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPA 1210
++ L +G +L + G VG S+ +A L V + + T L E
Sbjct: 2424 NVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPL-EPKTGRE 2482
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
L+ + V WYK + + +EKF + + + L I + D Y C
Sbjct: 2483 LQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 2542
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
A S+T++ VE E + E + + + + ++ EW +N +
Sbjct: 2543 GSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYN 2599
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
+ S + +L +K ++ DAGI +
Sbjct: 2600 DSFHEISHKGRRHTLVLKSIQRADAGIVR 2628
Score = 97.9 bits (233), Expect = 3e-19
Identities = 119/564 (21%), Positives = 219/564 (38%), Gaps = 39/564 (6%)
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVK 798
++ V +G+ LS V G P+P W K+ + V + D + + + K
Sbjct: 245 RTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
D G+YT A N G +S ++ V EP A P F R Q++ V+EK + + V +
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLVVVREP----AVP--FKKRLQDLEVREKESATFLCEVPQ 358
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P W++ + S +G L + NV ++ D Y C ++ G
Sbjct: 359 -PSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSAD-DDAVYIC-------ETPEG 409
Query: 919 ARVTIDVE-KVTFVKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISGMDHREII 976
+R ++ + ++ L + G T + + + V W N++E+ I
Sbjct: 410 SRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAIS 469
Query: 977 QEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEK-DVAI 1035
EG DVG + + D +TST V ++ D VK + + ++
Sbjct: 470 AEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTRFCVSAPRKPPLQPPVDPVVKARMESSV 529
Query: 1036 LEVEINSETADVVWERDGEIIKPKK-NKYDF---EKRGHIRKLYIRNTSVHDEGEYSCIL 1091
+ + DG +++ KK Y + + + + V +EG + +
Sbjct: 530 ILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRV 589
Query: 1092 RDESCTAEVTVVELP------PEIITR--LQNQKVNKGNKATFEIELTKGDALVRWFKDG 1143
+ + +E P P++ R L+ + +G + TF ++LT A WF DG
Sbjct: 590 SALNSFGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASA-GEWFLDG 648
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
++ S+ ++ D + L I + G V N ++I + T P
Sbjct: 649 QALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKP 708
Query: 1204 -----EFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
+L + +A L E+ D+ VTW K + K+ + + +R L++R
Sbjct: 709 PAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDV 768
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVE 1282
DD Y CV + +L V+
Sbjct: 769 ARDDAGLYECVSRGGRIAYQLSVQ 792
Score = 88.6 bits (210), Expect = 2e-16
Identities = 108/524 (20%), Positives = 207/524 (39%), Gaps = 37/524 (7%)
Query: 1139 WFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGNSKCTAILTVEE 1193
W KDG + + H+ + LKI C D G Y+C VG + + ++ V E
Sbjct: 271 WKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVRE 330
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
P++ F RL + + V A E+P + + W+K+++ + + K+ + + +R L
Sbjct: 331 PAVPFKKRLQD-LEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRL 389
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQA 1313
+R + DD Y C + T E+ + R+ ++ G V+ A
Sbjct: 390 TVRNVSADDDAVYICETPEGSRTV---AELAVQGNLLRKLPRKTAVRVGDTAMFCVEL-A 445
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
P W+ N + + S + +LTI + D G + +C
Sbjct: 446 VPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAF-MAGDC-QTSTRF 503
Query: 1374 NVTILDKP--SPPGKPNILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTTEWI-- 1428
V+ KP PP P + SS+ + W P + TI Y+VE +++ T WI
Sbjct: 504 CVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRC 563
Query: 1429 -SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP 1487
+ + + ++ ++ +++FR A+N S E + + +++P K
Sbjct: 564 HEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAPKLAVRTPL--KA 621
Query: 1488 LKNIT-TEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE---NRXXXXXXXXXXX 1543
++ + E ++LT G W+ DG+ LK A + YE +R
Sbjct: 622 VQAVEGGEVTFSVDLTVASAG------EWFLDGQALK-ASSVYEIHCDRTRHTLTIREVP 674
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV----GDEWLVTAVIEGI 1599
+ F +G +E+S + ++ P +T + +V +E + A +
Sbjct: 675 ASLHGAQLKFVANG-IESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSD- 732
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY 1643
V W K+G L +Y + V+ ++++ R + Y
Sbjct: 733 QAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLY 776
Score = 81.4 bits (192), Expect = 3e-14
Identities = 54/209 (25%), Positives = 96/209 (45%), Gaps = 15/209 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F +PKA V G D L C++V P P ++W + + +A + D++
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVTAGARFRLAQDGDLYR--- 66
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT----GEKEPPQVIEPLKSMIVRQG 749
L I ++ G Y A N GEA + L++ E+ P ++ P S+ VR+G
Sbjct: 67 -LTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRP-TSIRVREG 124
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTHSITILKPKKVKDEGVYT 804
+V G+PRP ++W K+ + + + + G+ ++ I + + +D G Y
Sbjct: 125 SEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRI-RAARPRDGGTYE 183
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPP 833
++AEN G A +A + V+ + A P
Sbjct: 184 VRAENPLGAASAAAALVVDSDAADTASRP 212
Score = 81.0 bits (191), Expect = 4e-14
Identities = 90/392 (22%), Positives = 152/392 (38%), Gaps = 27/392 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVAT 567
AP F+ + +GS F C+V G PRP ++W + + ++ ++ +
Sbjct: 109 APHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASA 168
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
L IR P D GT+ A+N G AS+ L+V++ +D S +
Sbjct: 169 LRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRRE 228
Query: 628 IL--EGIPPT-FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
+ EG P + S + V EG L C + P+P+ W K ++V + V
Sbjct: 229 AMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWK-KDGQLVTEGRRHVVY 287
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + VLKI K+ G YT A N G+ +++ ++ E P + L+ +
Sbjct: 288 EDAQENF--VLKILFCKQSDRGLYTCTASNLVGQTYSSVLVVVR--EPAVP-FKKRLQDL 342
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEG 801
VR+ ES + V P W K + A + +G +T+ + D+
Sbjct: 343 EVREKESATFLCE-VPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTV-RNVSADDDA 400
Query: 802 VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPV 861
VY E EG + T A + V+ + + T G + PV
Sbjct: 401 VYI--CETPEG-SRTVAELAVQGN---------LLRKLPRKTAVRVGDTAMFCVELAVPV 448
Query: 862 PSITWYRNNEIISPSETITQNFDGENIELVIT 893
+ W RN E + + + +G L I+
Sbjct: 449 GPVHWLRNQEEVVAGGRVAISAEGTRHTLTIS 480
Score = 78.6 bits (185), Expect = 2e-13
Identities = 55/195 (28%), Positives = 89/195 (45%), Gaps = 7/195 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P+ + K+ +V G+ LS Q+VGNP P ++W K+ +PV A DGD + +TI
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVTAGARFRLAQDGDLYRLTI 69
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIK 851
L + D G Y +A N+ G A + + V+ + P F+ R I V+E
Sbjct: 70 L-DLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 852 LVARVTRNPVPSITWYRNNEIISPSETITQNFD--GENIELVITNVDSEIDSGDYKCVAS 909
RV +P P+++W ++ + + + GE L I D G Y+ A
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPR-DGGTYEVRAE 187
Query: 910 NSAGKSSHGARVTID 924
N G +S A + +D
Sbjct: 188 NPLGAASAAAALVVD 202
Score = 72.1 bits (169), Expect = 2e-11
Identities = 57/248 (22%), Positives = 106/248 (42%), Gaps = 8/248 (3%)
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI---LRDESCTAEVTV 1102
+ VW++DG+++ + +E L I D G Y+C L ++ ++ + V
Sbjct: 268 ETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTYSSVLVV 327
Query: 1103 VELPP-EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
V P RLQ+ +V + ATF E+ + WFK+ + + S + +G ++
Sbjct: 328 VREPAVPFKKRLQDLEVREKESATFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTER 387
Query: 1162 KLKIYDCDLDDAGEYSCEV-GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+L + + DD Y CE S+ A L V+ N +LP V A VE+
Sbjct: 388 RLTVRNVSADDDAVYICETPEGSRTVAELAVQG---NLLRKLPRKTAVRVGDTAMFCVEL 444
Query: 1221 PDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLK 1280
V W + + + + + ++ + TL I +C +D + + D +++T+
Sbjct: 445 AVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTRFC 504
Query: 1281 VEVVEFPP 1288
V PP
Sbjct: 505 VSAPRKPP 512
Score = 70.5 bits (165), Expect = 6e-11
Identities = 60/207 (28%), Positives = 95/207 (45%), Gaps = 22/207 (10%)
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVI-LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDT- 786
T E + PQV+E L+ + V G + +V G P P + W K+ +P+ A D
Sbjct: 5254 TDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKK 5313
Query: 787 --HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV---EEPTEENAE-------PPL 834
H++ I+ + +D G Y N+ G A +SA + V +EP E+ A PP
Sbjct: 5314 ILHTLEIISVTR-EDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPR 5372
Query: 835 FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-----IISP-SETITQNFDGENI 888
+ RF VK+ +I +V PVP++ W R I P + T +
Sbjct: 5373 MLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQH 5432
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKS 915
LV+ +V + G Y C+ASN+AG++
Sbjct: 5433 SLVLLDVGRQ-HQGTYTCIASNAAGQA 5458
Score = 67.3 bits (157), Expect = 6e-10
Identities = 50/194 (25%), Positives = 78/194 (40%), Gaps = 11/194 (5%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK---SDGDTHSIT 790
PP E L GE+V L+ +V G P+P I+W K+ K V+ P D D
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
IL D G Y A ++ G T I V+ PP F+N+ E
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ-------VPPRFVNKVLASPFVEGEDA 6125
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETI-TQNFDGENIELVITNVDSEIDSGDYKCVAS 909
+ + P P I WY++ +++ T + + +++ S+ D G Y+C
Sbjct: 6126 QFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELV 6185
Query: 910 NSAGKSSHGARVTI 923
N G + A + I
Sbjct: 6186 NRLGSARASAELRI 6199
Score = 66.9 bits (156), Expect = 7e-10
Identities = 43/188 (22%), Positives = 77/188 (40%), Gaps = 9/188 (4%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY-----ENRXXXX 1536
P E+ L + T E E ++L C G P+P ++WY+DGK ++ +
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVI 1596
Y C A + G T + +Q P N+ + G++ T I
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFV--NKVLASPFVEGEDAQFTCTI 6131
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTS--VIRIKELKRSHSSKYTIEASNTAGTS 1654
EG P P++ WYK+G L ++ ++ ++ V+ I+ + Y E N G++
Sbjct: 6132 EGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSA 6191
Query: 1655 SVEVTLKV 1662
L++
Sbjct: 6192 RASAELRI 6199
Score = 65.3 bits (152), Expect = 2e-09
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 1/96 (1%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATL 568
P FV K+ +G QF C +EG P PQI W++ A++ FQ + + L
Sbjct: 6108 PRFVNKVLASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVL 6167
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
VIR ED G + C N G A ++ EL +++P+
Sbjct: 6168 VIRAASKEDLGLYECELVNRLGSARASAELRIQSPM 6203
Score = 61.3 bits (142), Expect = 4e-08
Identities = 57/221 (25%), Positives = 89/221 (40%), Gaps = 26/221 (11%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F+ + + G CQ+ G P PQ++W + + F++ D D +
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVTAGARFRLAQDGD-LY 65
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
L I ++ D+G + C A+NA G A + L V+A + +E
Sbjct: 66 RLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAA--CAEQA-------------- 109
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
P F +P + V EGS+ CR+ P P ++W G + + V +E
Sbjct: 110 -------PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEE 162
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
S L+I + GTY V A N G AS L +
Sbjct: 163 LGE--ASALRIRAARPRDGGTYEVRAENPLGAASAAAALVV 201
Score = 60.1 bits (139), Expect = 9e-08
Identities = 40/156 (25%), Positives = 66/156 (42%), Gaps = 7/156 (4%)
Query: 1597 EGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
E +P E WY NG ++ +D ++ +T + ++ + H+ + T + ++
Sbjct: 4457 EAVPVGEASWYINGAAVQPDDSDWTVTADGSHQALLLRSAQPHHAGEVTFACRDAVASAR 4516
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
L V P PE ++ S +VT+ W P+ DGG L Y +E E +W
Sbjct: 4517 ----LTVLGLPDPPEDAEVVAH-SSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRL 4571
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE 1751
++ E + L Y FRV A PVG E
Sbjct: 4572 CHELVPGPEC-VVDGLAPGETYRFRVAAVGPVGAGE 4606
Score = 59.7 bits (138), Expect = 1e-07
Identities = 47/211 (22%), Positives = 93/211 (44%), Gaps = 6/211 (2%)
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS--PSETITQNFDGENIE 889
PP F + T + T+KL RVT P P I+WY++ + + P + ++ DG +
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDG-SCA 6071
Query: 890 LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILE 949
L++ ++ +DSG Y C A+++AG S ++ + V K L + E
Sbjct: 6072 LILDSLTG-VDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVLASPFVEGEDAQFTCT 6130
Query: 950 CQTSHTVSTKWYHNKKEISGMDHREIIQEGRX--XXXXXXXXXXXDVGVIKCIVKDQETS 1007
+ + +WY + ++ + + + E R D+G+ +C + ++ S
Sbjct: 6131 IEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGS 6190
Query: 1008 TMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
+ I + + Q+ +E+ VA +EV
Sbjct: 6191 ARASAELRIQSPMLQAQEQCHREQLVAAVEV 6221
Score = 57.2 bits (132), Expect = 6e-07
Identities = 27/94 (28%), Positives = 48/94 (51%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F E+L G TV+ C+V G P+P I+W++ ++ + D D L+
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ + D+G + C A +AAG S+ +++V+ P
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVP 6107
Score = 54.4 bits (125), Expect = 4e-06
Identities = 30/119 (25%), Positives = 54/119 (45%), Gaps = 3/119 (2%)
Query: 815 ETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
ET A + EP + P+F+ Q V++ + VT P+PS+ W+++ +
Sbjct: 5105 ETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGK 5164
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
++ + N D + +I D G Y+C+A NS G SS A + +D+ +
Sbjct: 5165 LLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDY 5223
Score = 53.6 bits (123), Expect = 7e-06
Identities = 43/197 (21%), Positives = 85/197 (43%), Gaps = 11/197 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F ++ + G + L CR+ P+P I+W G+ + D + + IE D C
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPH-HILIE-DPDGSC 6070
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+++ + ++ G Y A + G S + ++ PP+ + + + +GE
Sbjct: 6071 ALI-LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQV----PPRFVNKVLASPFVEGEDA 6125
Query: 753 ILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTH-SITILKPKKVKDEGVYTLKAE 808
+ + G P P I W K+ + T S+ + + +++ +D G+Y +
Sbjct: 6126 QFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELV 6185
Query: 809 NSEGIAETSAVITVEEP 825
N G A SA + ++ P
Sbjct: 6186 NRLGSARASAELRIQSP 6202
Score = 53.2 bits (122), Expect = 1e-05
Identities = 69/334 (20%), Positives = 125/334 (37%), Gaps = 24/334 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
+Q P+F G ++ EC V + W + + + + D
Sbjct: 4893 KQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDG 4952
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I + DAG +TC N G + + ++V GSE
Sbjct: 4953 TCSLLIAGLDRADAGCYTCQVSNKFGQVTHSACVVVS------GSESEAESSSGGELDDA 5006
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLEC-RLVAIPEPDIAW-LFKGEE---IVPDEN 679
+ F K A+ DE ++ L A PE W ++ +E + E
Sbjct: 5007 FRRAARRLHRLFRTKSPAEVSDE--ELFLSADEGPAEPEEPADWQTYREDEHFICIRFEA 5064
Query: 680 ISVA---IESDMHMYCSVLKITNVKKFQEGTYTV-VAVNREGEASL--PIVLKIKTGEKE 733
++ A + M+ ++ +K ++G V + +++E A + P L
Sbjct: 5065 LTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDA 5124
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHSI 789
P + L++ V+ G V V G P P++ W K+ K ++ + + H +
Sbjct: 5125 APVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
I+ D GVY AENS G++ T A + V+
Sbjct: 5185 -IITAVVPADMGVYRCLAENSMGVSSTKAELRVD 5217
Score = 48.8 bits (111), Expect = 2e-04
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 6/118 (5%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHE 1924
P P + V +S +VTL W P S+GG + Y +E K W V G E
Sbjct: 4523 PDPPEDAEVVAHSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGP--E 4580
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRL-EKHATVPSPPTAPLEIRMVGS 1980
++ + + FR++A VG P Q+VRL E VP P+AP E R V +
Sbjct: 4581 CVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-ESRQVAA 4637
Score = 46.8 bits (106), Expect = 9e-04
Identities = 48/204 (23%), Positives = 80/204 (39%), Gaps = 15/204 (7%)
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP+ L + G +T ++ W+KDG +Q H L D
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 1165 IYDCDLD-DAGEYSC----EVGNSKCTAILTVEEPS--INFTLRLPEFILVPANTDAYLT 1217
I D D+G+Y C GN + V+ P +N L P F+ DA T
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVLASP-FV---EGEDAQFT 6128
Query: 1218 VEIPDETL-DVTWYKKKSVIEDTEKFTLISDVKK--RTLIIRKCTEDDQCEYTCVLLDAK 1274
I + WYK +++ KF +S+ + L+IR +++D Y C L++
Sbjct: 6129 CTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRL 6188
Query: 1275 STTKLKVEVVEFPPKIVDYEREYR 1298
+ + E+ P + E+ +R
Sbjct: 6189 GSARASAELRIQSPMLQAQEQCHR 6212
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/180 (23%), Positives = 75/180 (41%), Gaps = 15/180 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F+ + + F V A L +I + T V WE+D + + ++ + G + +L
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVTAGA-RFRLAQDGDLYRLT 68
Query: 1076 IRNTSVHDEGEYSCILRDE----------SCTAEVTVVELPPEIITRLQNQKVNKGNKAT 1125
I + ++ D G+Y C R+ AE E P + R + +V +G++AT
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 1126 FEIELTKGD-ALVRWFKDGSEIQFSNHIQLTID--GKKQKLKIYDCDLDDAGEYSCEVGN 1182
F + V W KDG + + ++ ++ G+ L+I D G Y N
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAEN 188
Score = 45.6 bits (103), Expect = 0.002
Identities = 45/201 (22%), Positives = 81/201 (40%), Gaps = 15/201 (7%)
Query: 1200 LRLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
L P+ +V DA L+ +I + T V+W K + + +F L D L I
Sbjct: 13 LTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVTAGARFRLAQDGDLYRLTILDL 72
Query: 1259 TEDDQCEYTC----VLLDAKSTTKLKVEV----VEFPPKIVDYEREYRIKRGSDVTLLVD 1310
D +Y C + +A + L+V+ E P + R++ GS+ T
Sbjct: 73 ALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEATFRCR 132
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPSID--SKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P+P W + + + + + ++ ++++L I+ D G Y++R EN G
Sbjct: 133 VGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGA 192
Query: 1369 ADVEMNVTI----LDKPSPPG 1385
A + + D S PG
Sbjct: 193 ASAAAALVVDSDAADTASRPG 213
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+ L PK + +V C P+ + W++ + PS+ F+M + +A L I
Sbjct: 2470 VLTRPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQ-MAELRI 2527
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+ P DAG + C AG A S+TE+ VEA
Sbjct: 2528 LRLMPADAGVYRC----QAGSAHSSTEVTVEA 2555
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/90 (30%), Positives = 41/90 (45%)
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
PE V A D L +E+ E +V W+K I+ +F ++S +++ L+I+ T +D
Sbjct: 4630 PESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAED 4689
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
Q EY C L V P VD
Sbjct: 4690 QGEYHCGLAQGSICPAAATFQVALSPASVD 4719
Score = 44.0 bits (99), Expect = 0.006
Identities = 27/95 (28%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 1092 RDESCTAEVTVVELPPEIITRLQNQKVNKGNK-ATFEIELTKGDALVR--WFKDGSEIQF 1148
R++ T T P+++ L++ +V G + A F++++ KG R WFKDG +
Sbjct: 5245 REQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKV-KGYPAPRLYWFKDGQPLTA 5303
Query: 1149 SNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
S HI++T L+I +D+G+Y+ + N+
Sbjct: 5304 SAHIRMTDKKILHTLEIISVTREDSGQYAAYISNA 5338
Score = 44.0 bits (99), Expect = 0.006
Identities = 34/155 (21%), Positives = 56/155 (36%), Gaps = 4/155 (2%)
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKR-TLIIRKCTEDDQCEYTCVLLDAKST-TKLKVEVV 1284
++WYK ++ LI D LI+ T D +Y C A + L +V
Sbjct: 6045 ISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILV 6104
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA- 1343
+ PP+ V+ G D + P P W + ++ + + +S
Sbjct: 6105 QVPPRFVNKVLASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL 6164
Query: 1344 -SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
L I+ D G+Y+ L N G A + I
Sbjct: 6165 LVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 43.6 bits (98), Expect = 0.008
Identities = 43/188 (22%), Positives = 70/188 (37%), Gaps = 17/188 (9%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-----NRXXXXXXXXXXX 1543
K +D L+C G P P+V+W +D + + TA A + +
Sbjct: 17 KAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPV-TAGARFRLAQDGDLYRLTILDLALG 75
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGI-------QQKPVITISNEDIKQKHKVGDEWLVTAVI 1596
Y C A N GE + + + +Q P + I+ + G E +
Sbjct: 76 DSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVRE--GSEATFRCRV 133
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
G P P V W K+G +L + +E + S +RI+ + Y + A N G +
Sbjct: 134 GGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAA 193
Query: 1655 SVEVTLKV 1662
S L V
Sbjct: 194 SAAAALVV 201
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 1031 KDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI 1090
+DV+ LE+E+ +E +V+W + E I+P +++ +G + L I+ + D+GEY C
Sbjct: 4639 EDVS-LELEVVAEAGEVIWHKGMERIQP-GGRFEVVSQGRQQMLVIKGFTAEDQGEYHCG 4696
Query: 1091 LRDES-CTAEVTV-VELPP 1107
L S C A T V L P
Sbjct: 4697 LAQGSICPAAATFQVALSP 4715
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 1965 VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTL 2024
+P PP E+ S+ V SW P DGG L GY + +++ W ++ V
Sbjct: 4522 LPDPPE-DAEVVAHSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHEL-VPGP 4579
Query: 2025 KFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
+ + L+ TY R+ A +G EP+
Sbjct: 4580 ECVVDGLAPGETYRFRVAAVGPVGAGEPV 4608
Score = 42.7 bits (96), Expect = 0.014
Identities = 28/80 (35%), Positives = 40/80 (50%), Gaps = 4/80 (5%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGK-KQKL 1163
P +T LQNQ+V G +F+ +T G + VRWFKDG ++ +H + D + +L
Sbjct: 5126 PVFLTELQNQEVQDGYPVSFDCVVT-GQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 5184
Query: 1164 KIYDCDLDDAGEYSCEVGNS 1183
I D G Y C NS
Sbjct: 5185 IITAVVPADMGVYRCLAENS 5204
Score = 42.3 bits (95), Expect = 0.018
Identities = 23/94 (24%), Positives = 42/94 (44%), Gaps = 1/94 (1%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVI 892
P F+ R + V L ++ NP P ++W ++ + ++ DG+ L I
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVTAGARFRLAQDGDLYRLTI 69
Query: 893 TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
++ DSG Y C A N+ G++ + +D E
Sbjct: 70 LDLALG-DSGQYVCRARNAIGEAFAAVGLQVDAE 102
Score = 40.7 bits (91), Expect = 0.056
Identities = 23/81 (28%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-- 1653
++G P P + W+K+G L +T K+ + I + R S +Y SN G
Sbjct: 5284 VKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAY 5343
Query: 1654 SSVEVTLKVYDKP-SKPEGPV 1673
SS + ++ D+P KP V
Sbjct: 5344 SSARLLVRGPDEPEEKPASDV 5364
Score = 40.3 bits (90), Expect = 0.074
Identities = 30/102 (29%), Positives = 37/102 (36%), Gaps = 2/102 (1%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
IL +PP F K A EG D C + P P I W G + E
Sbjct: 6102 ILVQVPPRFVNKVLASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPR 6161
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT 729
+ VL I K G Y VNR G A L+I++
Sbjct: 6162 SGLL--VLVIRAASKEDLGLYECELVNRLGSARASAELRIQS 6201
Score = 39.9 bits (89), Expect = 0.098
Identities = 23/78 (29%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +TR + V+ G AT ++ V W KD + +L DG +L I
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVTAGARFRLAQDGDLYRLTI 69
Query: 1166 YDCDLDDAGEYSCEVGNS 1183
D L D+G+Y C N+
Sbjct: 70 LDLALGDSGQYVCRARNA 87
Score = 39.9 bits (89), Expect = 0.098
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 1582 QKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS-VIRIKELKRS 1638
Q +V D + V+ V+ G P P V W+K+G LE D Y I ++ + I + +
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKV 1662
Y A N+ G SS + L+V
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRV 5216
Score = 39.1 bits (87), Expect = 0.17
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F++ L + T+ +C+V P + W + + PS + + LV+
Sbjct: 2648 VFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTA-GTRGLVV 2705
Query: 571 REVFPEDAGTFTC 583
+V PEDAG +TC
Sbjct: 2706 HDVSPEDAGLYTC 2718
Score = 38.7 bits (86), Expect = 0.23
Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 509 API-FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
AP+ F+ +L+ + +G T C++ + W + + + P +QM D A
Sbjct: 3977 APVRFLRELQHQEVDEGGTAHLCCELSR-AGASVEWRKGSLQLFPCAKYQMV-QDGAAAE 4034
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFAS 593
L++R V EDAG +TC + AS
Sbjct: 4035 LLVRGVEQEDAGDYTCDTGHTQSMAS 4060
Score = 38.3 bits (85), Expect = 0.30
Identities = 38/182 (20%), Positives = 71/182 (39%), Gaps = 14/182 (7%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK--ATYEN---RXXXXXXXXXXX 1543
+ T + L+C G P+P+ W +DG+ + + YE+
Sbjct: 245 RTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPP- 1602
Y C A N G+ +S +V + ++P + Q +V ++ T + E +P P
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLV-VVREPAVPFKKR--LQDLEVREKESATFLCE-VPQPS 360
Query: 1603 -EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY---TIEASNTAGTSSVEV 1658
E W+K +L +Y I + + ++ + + Y T E S T +V+
Sbjct: 361 TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAELAVQG 420
Query: 1659 TL 1660
L
Sbjct: 421 NL 422
Score = 38.3 bits (85), Expect = 0.30
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1114 QNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDA 1173
++++V G + E+E+ V W K IQ ++ G++Q L I +D
Sbjct: 4631 ESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQ 4690
Query: 1174 GEYSCEVG-NSKCTAILTVE 1192
GEY C + S C A T +
Sbjct: 4691 GEYHCGLAQGSICPAAATFQ 4710
Score = 37.5 bits (83), Expect = 0.52
Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
++ + G P PE +W K+G + + + + ++ V++I K+S YT ASN
Sbjct: 257 LSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNL 316
Query: 1651 AGTSSVEVTLKVYDKPSKP 1669
G + V L V +P+ P
Sbjct: 317 VGQTYSSV-LVVVREPAVP 334
Score = 37.5 bits (83), Expect = 0.52
Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F+ L +G F+C V + WFR A+++PS+ F + + +L I
Sbjct: 1901 FMSGLSTVVAEEGGEATFQCVVSPSD-VAVVWFRDGALLQPSEKFAISQSGAS-HSLTIS 1958
Query: 572 EVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++ EDAG T A G +SS + EAP+
Sbjct: 1959 DLVLEDAGQITV---EAEGASSSAALRVREAPV 1988
Score = 37.5 bits (83), Expect = 0.52
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V+F C+V + W Q ++ ++ ++ D + TL ++ V PEDAGT +
Sbjct: 4176 VEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLG 4235
Query: 587 NAAGFASSTT---ELIVEAPLSD 606
N A A T E+ + PL D
Sbjct: 4236 NHASSAQLTVRAPEVTILEPLQD 4258
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 3/54 (5%)
Query: 1131 TKGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+K D RW KDG E+ +HI DG L I D DAG Y+C+V N
Sbjct: 4923 SKADVRARWLKDGVELTDGRHHHIDQLGDG-TCSLLIAGLDRADAGCYTCQVSN 4975
Score = 35.1 bits (77), Expect = 2.8
Identities = 24/101 (23%), Positives = 44/101 (43%), Gaps = 2/101 (1%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTI-KLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E T + + P + +++ V + K +V P P + W+++ + ++ S I
Sbjct: 5251 ESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMT 5310
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
L I +V E DSG Y SN+ G + AR+ +
Sbjct: 5311 DKKILHTLEIISVTRE-DSGQYAAYISNAMGAAYSSARLLV 5350
Score = 34.7 bits (76), Expect = 3.7
Identities = 14/47 (29%), Positives = 22/47 (46%)
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
T +P L+N + + C+ G P P V W++DGK L+
Sbjct: 5121 TSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLE 5167
Score = 34.3 bits (75), Expect = 4.9
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 5/95 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+F E L+ +GST +C++ P + W + ++ + + A LV
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCELSE-PTATVVWSKGGLQLQANGRREPRLQGCT-AELV 3947
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++++ ED G +TC + A+S T + AP+
Sbjct: 3948 LQDLQREDTGEYTCTCGSQ---ATSATLTVTAAPV 3979
Score = 33.5 bits (73), Expect = 8.5
Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+T C+V P+ ++TW++ + S +M LV+++V DAG ++C
Sbjct: 1181 GTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGCT-RRLVVQQVGKADAGEYSC 1238
Query: 584 VA 585
A
Sbjct: 1239 EA 1240
Score = 33.5 bits (73), Expect = 8.5
Identities = 21/92 (22%), Positives = 40/92 (43%), Gaps = 3/92 (3%)
Query: 1781 NESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKX-XXXXXXXXARIQKLSINTTYQFR 1838
+ +V ++W +GG + Y+VE+K+ +W+ + L+ TY+FR
Sbjct: 4536 SHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFR 4595
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTP-PSQP 1869
+ A +G P + + + P P QP
Sbjct: 4596 VAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQP 4627
>AJ314905-1|CAC85752.1| 2212|Homo sapiens obscurin protein.
Length = 2212
Score = 184 bits (449), Expect = 2e-45
Identities = 178/740 (24%), Positives = 310/740 (41%), Gaps = 60/740 (8%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ +P F + K Q EG+ +L+C L + + W KG E + D + ++ D
Sbjct: 801 IRALPARFIEDVKNQEAREGATAVLQCELNSAAP--VEWR-KGSETLRDGD-RYSLRQD- 855
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y+ V A L + P + E L++ +
Sbjct: 856 GTKCE-LQIRGLAMADTGEYSCVCGQERTSAMLTV-------RALPIKFTEGLRNEEATE 907
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI--------LKPKKVKDE 800
G + +L ++ + + W K ++ ++ DGD HS+ ++ +D
Sbjct: 908 GATAVLRCEL--SKMAPVEWWKGHETLR------DGDRHSLRQDGARCELQIRGLVAEDA 959
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
G Y G TSA++TV A P FI + E T L +++
Sbjct: 960 GEYLCMC----GKERTSAMLTVR------AMPSKFIEGLRNEEATEGDTATLWCELSK-- 1007
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ W + +E + + + DG EL I + + +D+G+Y CV G+ A
Sbjct: 1008 AAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGL-AVVDAGEYSCVC----GQERTSAT 1062
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGR 980
+T+ F++ + K+ E EG T +L+C+ S +W + + G D + Q+G
Sbjct: 1063 LTVRALPARFIEDV-KNQEAREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQDGT 1121
Query: 981 XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + TS L V+ F + L+ E E A L+ E+
Sbjct: 1122 RCELQIHGLSVADTGEYSCVCGQERTSATLTVRALPARFTQDLKTKEASEGATATLQCEL 1181
Query: 1041 NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
S+ A V W++ E ++ +Y ++ G +L I + SV D GEYSC+ E +A +
Sbjct: 1182 -SKVAPVEWKKGPETLR-DGGRYSLKQDGTRCELQIHDLSVADAGEYSCMCGQERTSATL 1239
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKK 1160
TV LP L+N++ +G AT + EL+K A V W K ++ + L DG
Sbjct: 1240 TVRALPARFTEGLRNEEAMEGATATLQCELSKA-APVEWRKGLEALRDGDKYSLRQDGAV 1298
Query: 1161 QKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+L+I+ + D G YSC G + +A LTV F + + A A +T++
Sbjct: 1299 CELQIHGLAMADNGVYSCVCGQERTSATLTVRALPARF---IEDMRNQKATEGATVTLQC 1355
Query: 1221 P-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
+ V W K + ++D ++++L D L IR D EY+C+ +++ L
Sbjct: 1356 KLRKAAPVEWRKGPNTLKDGDRYSLKQDGTSCELQIRGLVIADAGEYSCICEQERTSATL 1415
Query: 1280 KVEVVEFPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHTKPSI 1338
V + P + ++ R + G+ L + +A P EW S+ ++
Sbjct: 1416 TVRAL--PARFIEDVRNHEATEGATAVLQCELSKAAPV---EWRKGSETLRDGDRYSLRQ 1470
Query: 1339 DSKSASLTIKKVENTDAGIY 1358
D L I+ + D G Y
Sbjct: 1471 DGTRCELQIRGLAVEDTGEY 1490
Score = 174 bits (424), Expect = 3e-42
Identities = 178/754 (23%), Positives = 305/754 (40%), Gaps = 51/754 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P F + K V EG L C L ++ P + W + + P + S+ E M
Sbjct: 452 PVRFQEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQEGAM---- 506
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L + N++ G Y+ ++ A+L + P Q I L++ +G +
Sbjct: 507 LELVVRNLRPQDSGRYSCSFGDQTTSATLTVTAL-------PAQFIGKLRNKEATEGATA 559
Query: 753 ILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L ++ + + W K ++ ++ + DG + I + + D Y+
Sbjct: 560 TLRCEL--SKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQI-RGLAMVDAAEYSCVC-- 614
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G TSA +T+ P FI R + E T L +++ + W +
Sbjct: 615 --GEERTSASLTIRPM------PAHFIGRLRHQESIEGATATLRCELSK--AAPVEWRKG 664
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
E + + + DG EL I + + D+G+Y CV G+ A +T+
Sbjct: 665 RESLRDGDRHSLRQDGAVCELQICGL-AVADAGEYSCVC----GEERTSATLTVKALPAK 719
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
F + L+ E EG T +L C+ S +W + + D + QEG
Sbjct: 720 FTEGLRNE-EAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGL 778
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVW 1049
D G C+ + TS L ++ FI +++ E +E A+L+ E+NS A V W
Sbjct: 779 AMADAGEYLCVCGQERTSATLTIRALPARFIEDVKNQEAREGATAVLQCELNS-AAPVEW 837
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEI 1109
+ E ++ ++Y + G +L IR ++ D GEYSC+ E +A +TV LP +
Sbjct: 838 RKGSETLR-DGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRALPIKF 896
Query: 1110 ITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
L+N++ +G A EL+K A V W+K ++ + L DG + +L+I
Sbjct: 897 TEGLRNEEATEGATAVLRCELSK-MAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLV 955
Query: 1170 LDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+DAGEY C G + +A+LTV F L +T A L E+ + V W
Sbjct: 956 AEDAGEYLCMCGKERTSAMLTVRAMPSKFIEGLRNEEATEGDT-ATLWCEL-SKAAPVEW 1013
Query: 1230 YKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPK 1289
K + D ++ +L D + L IR D EY+CV +++ L V + P +
Sbjct: 1014 RKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRAL--PAR 1071
Query: 1290 IVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIK 1348
++ + + G+ L + +A P EW S+ ++ D L I
Sbjct: 1072 FIEDVKNQEAREGATAVLQCELSKAAPV---EWRKGSETLRGGDRYSLRQDGTRCELQIH 1128
Query: 1349 KVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
+ D G Y CG +T+ P+
Sbjct: 1129 GLSVADTGEYSC----VCGQERTSATLTVRALPA 1158
Score = 173 bits (420), Expect = 8e-42
Identities = 164/674 (24%), Positives = 279/674 (41%), Gaps = 57/674 (8%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLV-AIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ +P F++ + + EG+ L+C L A P + W KG E + D + ++ D
Sbjct: 1241 VRALPARFTEGLRNEEAMEGATATLQCELSKAAP---VEWR-KGLEALRDGD-KYSLRQD 1295
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ C L+I + G Y+ V A+L + P + IE +++
Sbjct: 1296 GAV-CE-LQIHGLAMADNGVYSCVCGQERTSATLTV-------RALPARFIEDMRNQKAT 1346
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYT 804
+G +V L ++ + W K +K K DG + + I + + D G Y+
Sbjct: 1347 EGATVTLQCKL--RKAAPVEWRKGPNTLKDGDRYSLKQDGTSCELQI-RGLVIADAGEYS 1403
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
E TSA +TV A P FI + E T L +++ +
Sbjct: 1404 CICEQER----TSATLTVR------ALPARFIEDVRNHEATEGATAVLQCELSK--AAPV 1451
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + +E + + + DG EL I + E D+G+Y CV G+ A +T+
Sbjct: 1452 EWRKGSETLRDGDRYSLRQDGTRCELQIRGLAVE-DTGEYLCVC----GQERTSATLTVR 1506
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXX 984
F+ ++ E EG T L C+ S +W + + D + Q+G
Sbjct: 1507 ALPARFIDNMTNQ-EAREGATATLHCELSKVAPVEWRKGPETLRDGDRHSLRQDGTRCEL 1565
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D G C+ + TS L ++E E A+L+ E+ S+
Sbjct: 1566 QIRGLSVADAGEYSCVCGQERTSATLTIREAT-------------EGATAMLQCEL-SKV 1611
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
A V W + E ++ ++Y+ + G +L I SV D GEYSC+ E +A +TV
Sbjct: 1612 APVEWRKGPETLRDG-DRYNLRQDGTRCELQIHGLSVADTGEYSCVCGQEKTSATLTVKA 1670
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P LQ+ + +G+ AT + EL++ A V W K G ++Q + + + G +L
Sbjct: 1671 PQPVFREPLQSLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELV 1730
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+ D +D GEY+C G+ +A LTV + F LR + V A+L E+
Sbjct: 1731 LQDLQREDTGEYTCTCGSQATSATLTVTAAPVRF-LRELQHQEVDEGGTAHLCCELSRAG 1789
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV- 1283
V W K + K+ ++ D L++R ++D +YTC +S L V V
Sbjct: 1790 ASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRVP 1849
Query: 1284 -VEFPPKIVDYERE 1296
+F ++ E+E
Sbjct: 1850 RPKFKTRLQSLEQE 1863
Score = 169 bits (411), Expect = 9e-41
Identities = 196/905 (21%), Positives = 360/905 (39%), Gaps = 73/905 (8%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ +P F++ K + EG+ L+C L + + W KG E + D +++ D
Sbjct: 1153 VRALPARFTQDLKTKEASEGATATLQCELSKVAP--VEWK-KGPETLRDGG-RYSLKQD- 1207
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I ++ G Y+ + A+L + P + E L++ +
Sbjct: 1208 GTRCE-LQIHDLSVADAGEYSCMCGQERTSATLTV-------RALPARFTEGLRNEEAME 1259
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTL 805
G + L ++ + + W K + ++ + DG + I + D GVY+
Sbjct: 1260 GATATLQCEL--SKAAPVEWRKGLEALRDGDKYSLRQDGAVCELQI-HGLAMADNGVYSC 1316
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
G TSA +TV A P FI + E T+ L ++ R P +
Sbjct: 1317 VC----GQERTSATLTVR------ALPARFIEDMRNQKATEGATVTLQCKL-RKAAP-VE 1364
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W + + + + DG + EL I + D+G+Y C+ ++S A +T+
Sbjct: 1365 WRKGPNTLKDGDRYSLKQDGTSCELQIRGLVIA-DAGEYSCICEQE--RTS--ATLTVRA 1419
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
F++ + +++E EG T +L+C+ S +W + + D + Q+G
Sbjct: 1420 LPARFIEDV-RNHEATEGATAVLQCELSKAAPVEWRKGSETLRDGDRYSLRQDGTRCELQ 1478
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G C+ + TS L V+ FI + + E +E A L E+ S+ A
Sbjct: 1479 IRGLAVEDTGEYLCVCGQERTSATLTVRALPARFIDNMTNQEAREGATATLHCEL-SKVA 1537
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W + E ++ +++ + G +L IR SV D GEYSC+ E +A +T+ E
Sbjct: 1538 PVEWRKGPETLRDG-DRHSLRQDGTRCELQIRGLSVADAGEYSCVCGQERTSATLTIRE- 1595
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
+G A + EL+K A V W K ++ + L DG + +L+I
Sbjct: 1596 ------------ATEGATAMLQCELSKV-APVEWRKGPETLRDGDRYNLRQDGTRCELQI 1642
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
+ + D GEYSC G K +A LTV+ P F L +T A L E+ + T
Sbjct: 1643 HGLSVADTGEYSCVCGQEKTSATLTVKAPQPVFREPLQSLQAEEGST-ATLQCELSEPTA 1701
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
V W K ++ + L+++ +D EYTC T + V
Sbjct: 1702 TVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC--GSQATSATLTVTA 1759
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
P + + + + G L + + EW S + C + D +A L
Sbjct: 1760 APVRFLRELQHQEVDEGGTAHLCCELSR-AGASVEWRKGSLQLFPCAKYQMVQDGAAAEL 1818
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEMNVTI-LDKPSPPGKPNILEIDSSSINICWDEP 1404
++ VE DAG Y + GH ++++ + +P + LE ++ I +
Sbjct: 1819 LVRGVEQEDAGDYTC----DTGHTQSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQL 1874
Query: 1405 ENTGNSTIIYYVVEYQEIDTTEWISVKNITKT-QTSIQNLKTNSSYRFRAYAVNEVDISD 1463
+ + ++ ++ E E+ +++ T + I L+ + + ++
Sbjct: 1875 SDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEYAC-------VTG 1927
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+T +V E ++ T+ + L + +ED+E +C V W G L+
Sbjct: 1928 GQKTAASLRVTGEPEV---TIVRGLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLPLQ 1984
Query: 1524 TAKAT 1528
+ + T
Sbjct: 1985 SNEVT 1989
Score = 144 bits (348), Expect = 4e-33
Identities = 151/658 (22%), Positives = 260/658 (39%), Gaps = 37/658 (5%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD---GDTHS 788
+ P +I+PL+ V GE V L ++ P + W K+ K ++ K D T +
Sbjct: 91 ERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRK-SQKYDVVCEGTMA 148
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+ +++ +KD G YT + E S +++A + VEE F + V+EKG
Sbjct: 149 MLVIRGASLKDAGEYTCEVEAS----KSTASLHVEEKAN------CFTEELTNLQVEEKG 198
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVA 908
T + T +P ++TW + + S + +G + L I+ ++ + DS Y C
Sbjct: 199 TAVFTCK-TEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALE-KADSDTYTC-- 254
Query: 909 SNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKE 966
G++ A++ + + + + + +EG + C+ S + W+ +K
Sbjct: 255 --DIGQAQSRAQLLVQAGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTP 312
Query: 967 ISGMDHREI-IQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQD 1025
+ + EI Q G D G I DQ S L V E F R+L D
Sbjct: 313 LHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASAALRVTEKPSVFSRELTD 372
Query: 1026 FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEG 1085
+ E + L E ++ V W +DG+ ++ + GH +L I ++ D G
Sbjct: 373 ATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSA-RCQLSHEGHRAQLLITGATLQDSG 431
Query: 1086 EYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSE 1145
Y C ++ V V P L++ +V +G AT L+ A V+W +
Sbjct: 432 RYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGGAATLRCVLSSVAAPVKWCYGNNV 491
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEF 1205
++ + L +G +L + + D+G YSC G+ +A LTV F +L
Sbjct: 492 LRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGDQTTSATLTVTALPAQFIGKLRNK 551
Query: 1206 ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
T A L E+ + V W K + D +++ L D L IR D E
Sbjct: 552 EATEGAT-ATLRCEL-SKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAE 609
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVN 1324
Y+CV + +++ L + P + R G+ TL + +A P EW
Sbjct: 610 YSCVCGEERTSASLTIR--PMPAHFIGRLRHQESIEGATATLRCELSKAAPV---EWRKG 664
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
+ ++ D L I + DAG Y CG +T+ P+
Sbjct: 665 RESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPA 718
Score = 142 bits (345), Expect = 9e-33
Identities = 176/764 (23%), Positives = 303/764 (39%), Gaps = 75/764 (9%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLV-AIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ +P F + + EG+ +L+C L A P + W KG E + D + ++ D
Sbjct: 1417 VRALPARFIEDVRNHEATEGATAVLQCELSKAAP---VEWR-KGSETLRDGD-RYSLRQD 1471
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
C L+I + G Y V A+L + P + I+ + + R
Sbjct: 1472 -GTRCE-LQIRGLAVEDTGEYLCVCGQERTSATLTV-------RALPARFIDNMTNQEAR 1522
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI--------LKPKKVKD 799
+G + L ++ + + W K + ++ DGD HS+ ++ V D
Sbjct: 1523 EGATATLHCEL--SKVAPVEWRKGPETLR------DGDRHSLRQDGTRCELQIRGLSVAD 1574
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRN 859
G Y+ G TSA +T+ E TE T L +++
Sbjct: 1575 AGEYSCVC----GQERTSATLTIREATEG-------------------ATAMLQCELSK- 1610
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
V + W + E + + DG EL I + S D+G+Y CV G+ A
Sbjct: 1611 -VAPVEWRKGPETLRDGDRYNLRQDGTRCELQIHGL-SVADTGEYSCVC----GQEKTSA 1664
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQE 978
+T+ + F + LQ S + EEG T L+C+ S T + W ++ RE +
Sbjct: 1665 TLTVKAPQPVFREPLQ-SLQAEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQ 1723
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
G D G C Q TS L V F+R+LQ EV E A L
Sbjct: 1724 GCTAELVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCC 1783
Query: 1039 EINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA 1098
E++ A V W + + P KY + G +L +R D G+Y+C A
Sbjct: 1784 ELSRAGASVEWRKGSLQLFPCA-KYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMA 1842
Query: 1099 EVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRWFKDGSEIQFSNHIQLTI 1156
++V P+ TRLQ+ + G+ A +L+ + A+V+W K+G E+ ++
Sbjct: 1843 SLSVRVPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRS 1902
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-EPSINFTLRLPEFILVPANTDAY 1215
G ++L I+ + D GEY+C G K A L V EP + L + V A+ D
Sbjct: 1903 QGATRELLIHQLEAKDTGEYACVTGGQKTAASLRVTGEPEVTIVRGLVD-AEVTADEDVE 1961
Query: 1216 LTVEIPDE-TLDVTWYKKKSVIEDTEKFTL-ISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
+ E+ V W + ++ E + + D + TL ++ T +D + L +
Sbjct: 1962 FSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNH 2021
Query: 1274 KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH 1333
S+ +L V E I++ ++ ++ G D + W + ++ +
Sbjct: 2022 ASSAQLTVRAPEV--TILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEM 2079
Query: 1334 TKPSIDSKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+++ + LT+ KV DAG + C ++ ++ VT
Sbjct: 2080 NDITVEQGTLHLLTLHKVTLEDAGTVSFHV-GTCS-SEAQLKVT 2121
Score = 104 bits (249), Expect = 4e-21
Identities = 103/444 (23%), Positives = 173/444 (38%), Gaps = 9/444 (2%)
Query: 936 KSYETEEGKTVILECQTSHTVSTK---WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXX 992
K+ E EG++ EC SH ++ W K + + ++GR
Sbjct: 10 KTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPS 69
Query: 993 DVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERD 1052
D G + V+ + L+V+E I+ L+D V + L E++ V W +D
Sbjct: 70 DAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTPVHWLKD 129
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR 1112
+ I+ K KYD G + L IR S+ D GEY+C + TA + V E
Sbjct: 130 RKAIR-KSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEE 188
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
L N +V + A F + A V W K E++ S Q + +G +L I + D
Sbjct: 189 LTNLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKAD 248
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI-PDETLDVTWYK 1231
+ Y+C++G ++ A L V+ + E + V + A I P V W+
Sbjct: 249 SDTYTCDIGQAQSRAQLLVQAGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFL 308
Query: 1232 KKSVIEDTEKFTLISDV-KKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
K+ + E + + L +R+ D D +++ L+ V E P
Sbjct: 309 DKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASAALR--VTEKPSVF 366
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
+ I G D+TL+ + P W + K ++ + S + A L I
Sbjct: 367 SRELTDATITEGEDLTLVCETSTCDIPVC-WTKDGKTLRGSARCQLSHEGHRAQLLITGA 425
Query: 1351 ENTDAGIYKLRLENNCGHADVEMN 1374
D+G YK C + V ++
Sbjct: 426 TLQDSGRYKCEAGGACSSSIVRVH 449
Score = 99.1 bits (236), Expect = 2e-19
Identities = 81/288 (28%), Positives = 123/288 (42%), Gaps = 5/288 (1%)
Query: 1021 RKLQDFEVKEKDVAILEVEINSETAD--VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRN 1078
++L+ EV E + E ++ E+A +W G+ + +++ ++G L +R
Sbjct: 7 KRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVG-SSSRFQATRQGRKYILVVRE 65
Query: 1079 TSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR 1138
+ D GE +R + A + V E P II L++Q V G EL++ V
Sbjct: 66 AAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTPVH 125
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINF 1198
W KD I+ S + +G L I L DAGEY+CEV SK TA L VEE + F
Sbjct: 126 WLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCF 185
Query: 1199 TLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
T L + V A T + VTW K + + K + L I
Sbjct: 186 TEELTN-LQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISAL 244
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
+ D YTC + A+S +L V+ I D E + ++ GS T
Sbjct: 245 EKADSDTYTCDIGQAQSRAQLLVQAGRRVHIIEDLE-DVDVQEGSSAT 291
Score = 82.6 bits (195), Expect = 1e-14
Identities = 141/652 (21%), Positives = 248/652 (38%), Gaps = 70/652 (10%)
Query: 1109 IITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
I RL+ +V +G +FE L+ A W G + S+ Q T G+K L +
Sbjct: 5 ITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVR 64
Query: 1167 DCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD 1226
+ DAGE V A L V E L + + P D L E+
Sbjct: 65 EAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGE-DVELRCELSRAGTP 123
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE- 1285
V W K + I ++K+ ++ + L+IR + D EYTC + +KST L VE
Sbjct: 124 VHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKAN 183
Query: 1286 -FPPKIVDYEREYRIKRGSDV-TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
F ++ + + E ++G+ V T ++ P W ++ +PS + +
Sbjct: 184 CFTEELTNLQVE---EKGTAVFTCKTEH---PAATVTWRKGLLELRASGKHQPSQEGLTL 237
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDE 1403
LTI +E D+ Y C + +L + + +I+E D +++
Sbjct: 238 RLTISALEKADSDTY------TCDIGQAQSRAQLLVQAGR--RVHIIE-DLEDVDV---- 284
Query: 1404 PENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISD 1463
G+S + + W K T + N + + ++ + D
Sbjct: 285 --QEGSSATFRCRISPANYEPVHWFLDK--TPLHANELNEIDAQPGGYHVLTLRQLALKD 340
Query: 1464 ASETTEYYKVIKETKIQSPTV-EKP------LKNITTEPNEDIELTCIFGGVPQPKVTWY 1516
+ T Y++ + + V EKP L + T ED+ L C P V W
Sbjct: 341 SG--TIYFEAGDQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCETSTCDIP-VCWT 397
Query: 1517 RDGKKLKTA---KATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
+DGK L+ + + ++E +R YKC A G +S +V + +PV
Sbjct: 398 KDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCEA----GGACSSSIVRVHARPV 453
Query: 1573 ITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIR 1631
E +K + G + V+ + P V W N L +Y++ + +
Sbjct: 454 RF--QEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQEGAMLELV 510
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPL 1691
++ L+ S +Y S + G + TL V P++ G + +E +
Sbjct: 511 VRNLRPQDSGRY----SCSFGDQTTSATLTVTALPAQFIGKLRNKEAT------------ 554
Query: 1692 DDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
+G + + K P W K ++ RD + YC+++ CE R +A
Sbjct: 555 -EGATATLRCELSKAAPVE--WRKGSETLRDGDRYCLRQDGAMCELQIRGLA 603
Score = 38.7 bits (86), Expect = 0.23
Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 509 API-FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
AP+ F+ +L+ + +G T C++ + W + + + P +QM D A
Sbjct: 1760 APVRFLRELQHQEVDEGGTAHLCCELSR-AGASVEWRKGSLQLFPCAKYQMV-QDGAAAE 1817
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFAS 593
L++R V EDAG +TC + AS
Sbjct: 1818 LLVRGVEQEDAGDYTCDTGHTQSMAS 1843
Score = 37.5 bits (83), Expect = 0.52
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V+F C+V + W Q ++ ++ ++ D + TL ++ V PEDAGT +
Sbjct: 1960 VEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLG 2019
Query: 587 NAAGFASSTT---ELIVEAPLSD 606
N A A T E+ + PL D
Sbjct: 2020 NHASSAQLTVRAPEVTILEPLQD 2042
Score = 36.7 bits (81), Expect = 0.91
Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 2/85 (2%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
++ L + G V+ C++ P + W + I+ SQ + + + +A LVIR
Sbjct: 97 IKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQKYDVVCEG-TMAMLVIRG 154
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTE 597
+DAG +TC + + AS E
Sbjct: 155 ASLKDAGEYTCEVEASKSTASLHVE 179
Score = 34.3 bits (75), Expect = 4.9
Identities = 19/88 (21%), Positives = 40/88 (45%), Gaps = 3/88 (3%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F+E +R + +G+TV +C++ + W + +K + + D + L IR
Sbjct: 1336 FIEDMRNQKATEGATVTLQCKLR--KAAPVEWRKGPNTLKDGDRYSLKQDGTS-CELQIR 1392
Query: 572 EVFPEDAGTFTCVAKNAAGFASSTTELI 599
+ DAG ++C+ + A+ T +
Sbjct: 1393 GLVIADAGEYSCICEQERTSATLTVRAL 1420
Score = 34.3 bits (75), Expect = 4.9
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 5/95 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+F E L+ +GST +C++ P + W + ++ + + A LV
Sbjct: 1673 PVFREPLQSLQAEEGSTATLQCELSE-PTATVVWSKGGLQLQANGRREPRLQGCT-AELV 1730
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++++ ED G +TC + A+S T + AP+
Sbjct: 1731 LQDLQREDTGEYTCTCGSQ---ATSATLTVTAAPV 1762
>AB046776-1|BAB13382.1| 1596|Homo sapiens KIAA1556 protein protein.
Length = 1596
Score = 184 bits (449), Expect = 2e-45
Identities = 178/740 (24%), Positives = 310/740 (41%), Gaps = 60/740 (8%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ +P F + K Q EG+ +L+C L + + W KG E + D + ++ D
Sbjct: 808 IRALPARFIEDVKNQEAREGATAVLQCELNSAAP--VEWR-KGSETLRDGD-RYSLRQD- 862
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y+ V A L + P + E L++ +
Sbjct: 863 GTKCE-LQIRGLAMADTGEYSCVCGQERTSAMLTV-------RALPIKFTEGLRNEEATE 914
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI--------LKPKKVKDE 800
G + +L ++ + + W K ++ ++ DGD HS+ ++ +D
Sbjct: 915 GATAVLRCEL--SKMAPVEWWKGHETLR------DGDRHSLRQDGARCELQIRGLVAEDA 966
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
G Y G TSA++TV A P FI + E T L +++
Sbjct: 967 GEYLCMC----GKERTSAMLTVR------AMPSKFIEGLRNEEATEGDTATLWCELSK-- 1014
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ W + +E + + + DG EL I + + +D+G+Y CV G+ A
Sbjct: 1015 AAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGL-AVVDAGEYSCVC----GQERTSAT 1069
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGR 980
+T+ F++ + K+ E EG T +L+C+ S +W + + G D + Q+G
Sbjct: 1070 LTVRALPARFIEDV-KNQEAREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQDGT 1128
Query: 981 XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G C+ + TS L V+ F + L+ E E A L+ E+
Sbjct: 1129 RCELQIHGLSVADTGEYSCVCGQERTSATLTVRALPARFTQDLKTKEASEGATATLQCEL 1188
Query: 1041 NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
S+ A V W++ E ++ +Y ++ G +L I + SV D GEYSC+ E +A +
Sbjct: 1189 -SKVAPVEWKKGPETLR-DGGRYSLKQDGTRCELQIHDLSVADAGEYSCMCGQERTSATL 1246
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKK 1160
TV LP L+N++ +G AT + EL+K A V W K ++ + L DG
Sbjct: 1247 TVRALPARFTEGLRNEEAMEGATATLQCELSKA-APVEWRKGLEALRDGDKYSLRQDGAV 1305
Query: 1161 QKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+L+I+ + D G YSC G + +A LTV F + + A A +T++
Sbjct: 1306 CELQIHGLAMADNGVYSCVCGQERTSATLTVRALPARF---IEDMRNQKATEGATVTLQC 1362
Query: 1221 P-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
+ V W K + ++D ++++L D L IR D EY+C+ +++ L
Sbjct: 1363 KLRKAAPVEWRKGPNTLKDGDRYSLKQDGTSCELQIRGLVIADAGEYSCICEQERTSATL 1422
Query: 1280 KVEVVEFPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHTKPSI 1338
V + P + ++ R + G+ L + +A P EW S+ ++
Sbjct: 1423 TVRAL--PARFIEDVRNHEATEGATAVLQCELSKAAPV---EWRKGSETLRDGDRYSLRQ 1477
Query: 1339 DSKSASLTIKKVENTDAGIY 1358
D L I+ + D G Y
Sbjct: 1478 DGTRCELQIRGLAVEDTGEY 1497
Score = 174 bits (424), Expect = 3e-42
Identities = 178/754 (23%), Positives = 305/754 (40%), Gaps = 51/754 (6%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P F + K V EG L C L ++ P + W + + P + S+ E M
Sbjct: 459 PVRFQEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQEGAM---- 513
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L + N++ G Y+ ++ A+L + P Q I L++ +G +
Sbjct: 514 LELVVRNLRPQDSGRYSCSFGDQTTSATLTVTAL-------PAQFIGKLRNKEATEGATA 566
Query: 753 ILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L ++ + + W K ++ ++ + DG + I + + D Y+
Sbjct: 567 TLRCEL--SKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQI-RGLAMVDAAEYSCVC-- 621
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G TSA +T+ P FI R + E T L +++ + W +
Sbjct: 622 --GEERTSASLTIRPM------PAHFIGRLRHQESIEGATATLRCELSK--AAPVEWRKG 671
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
E + + + DG EL I + + D+G+Y CV G+ A +T+
Sbjct: 672 RESLRDGDRHSLRQDGAVCELQICGL-AVADAGEYSCVC----GEERTSATLTVKALPAK 726
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
F + L+ E EG T +L C+ S +W + + D + QEG
Sbjct: 727 FTEGLRNE-EAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGL 785
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVW 1049
D G C+ + TS L ++ FI +++ E +E A+L+ E+NS A V W
Sbjct: 786 AMADAGEYLCVCGQERTSATLTIRALPARFIEDVKNQEAREGATAVLQCELNS-AAPVEW 844
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEI 1109
+ E ++ ++Y + G +L IR ++ D GEYSC+ E +A +TV LP +
Sbjct: 845 RKGSETLR-DGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCGQERTSAMLTVRALPIKF 903
Query: 1110 ITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD 1169
L+N++ +G A EL+K A V W+K ++ + L DG + +L+I
Sbjct: 904 TEGLRNEEATEGATAVLRCELSK-MAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLV 962
Query: 1170 LDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+DAGEY C G + +A+LTV F L +T A L E+ + V W
Sbjct: 963 AEDAGEYLCMCGKERTSAMLTVRAMPSKFIEGLRNEEATEGDT-ATLWCEL-SKAAPVEW 1020
Query: 1230 YKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPK 1289
K + D ++ +L D + L IR D EY+CV +++ L V + P +
Sbjct: 1021 RKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRAL--PAR 1078
Query: 1290 IVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIK 1348
++ + + G+ L + +A P EW S+ ++ D L I
Sbjct: 1079 FIEDVKNQEAREGATAVLQCELSKAAPV---EWRKGSETLRGGDRYSLRQDGTRCELQIH 1135
Query: 1349 KVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
+ D G Y CG +T+ P+
Sbjct: 1136 GLSVADTGEYSC----VCGQERTSATLTVRALPA 1165
Score = 174 bits (424), Expect = 3e-42
Identities = 166/683 (24%), Positives = 285/683 (41%), Gaps = 46/683 (6%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ +P F++ + + EG+ +L C L + + W +KG E + D + ++ D
Sbjct: 896 VRALPIKFTEGLRNEEATEGATAVLRCELSKMAP--VEW-WKGHETLRDGDRH-SLRQD- 950
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
C L+I + G Y + A L + P + IE L++ +
Sbjct: 951 GARCE-LQIRGLVAEDAGEYLCMCGKERTSAMLTV-------RAMPSKFIEGLRNEEATE 1002
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKA 807
G++ L ++ + + W K ++ ++ DGD HS+ + +++ G+ + A
Sbjct: 1003 GDTATLWCEL--SKAAPVEWRKGHETLR------DGDRHSLRQDGSRCELQIRGLAVVDA 1054
Query: 808 ENSE---GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P FI + +E T L +++ +
Sbjct: 1055 GEYSCVCGQERTSATLTVR------ALPARFIEDVKNQEAREGATAVLQCELSK--AAPV 1106
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + +E + + + DG EL I + S D+G+Y CV G+ A +T+
Sbjct: 1107 EWRKGSETLRGGDRYSLRQDGTRCELQIHGL-SVADTGEYSCVC----GQERTSATLTVR 1161
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXX 984
F + L K+ E EG T L+C+ S +W + + + Q+G
Sbjct: 1162 ALPARFTQDL-KTKEASEGATATLQCELSKVAPVEWKKGPETLRDGGRYSLKQDGTRCEL 1220
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D G C+ + TS L V+ F L++ E E A L+ E+ S+
Sbjct: 1221 QIHDLSVADAGEYSCMCGQERTSATLTVRALPARFTEGLRNEEAMEGATATLQCEL-SKA 1279
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
A V W + E ++ +KY + G + +L I ++ D G YSC+ E +A +TV
Sbjct: 1280 APVEWRKGLEALRDG-DKYSLRQDGAVCELQIHGLAMADNGVYSCVCGQERTSATLTVRA 1338
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
LP I ++NQK +G T + +L K A V W K + ++ + L DG +L+
Sbjct: 1339 LPARFIEDMRNQKATEGATVTLQCKLRKA-APVEWRKGPNTLKDGDRYSLKQDGTSCELQ 1397
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
I + DAGEYSC + +A LTV F + T A L E+ +
Sbjct: 1398 IRGLVIADAGEYSCICEQERTSATLTVRALPARFIEDVRNHEATEGAT-AVLQCEL-SKA 1455
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
V W K + D ++++L D + L IR +D EY CV +++ L V +
Sbjct: 1456 APVEWRKGSETLRDGDRYSLRQDGTRCELQIRGLAVEDTGEYLCVCGQERTSATLTVRAL 1515
Query: 1285 EFPPKIVDYEREYRIKRGSDVTL 1307
P + +D + G+ TL
Sbjct: 1516 --PARFIDNMTNQEAREGATATL 1536
Score = 147 bits (356), Expect = 4e-34
Identities = 153/658 (23%), Positives = 263/658 (39%), Gaps = 38/658 (5%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD---GDTHS 788
+ P +I+PL+ V GE V L ++ P + W K+ K ++ K D T +
Sbjct: 99 ERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRK-SQKYDVVCEGTMA 156
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+ +++ +KD G YT + E S +++A + VEE F + V+EKG
Sbjct: 157 MLVIRGASLKDAGEYTCEVEAS----KSTASLHVEEKAN------CFTEELTNLQVEEKG 206
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVA 908
T + T +P ++TW + + S + +G + L I+ ++ + DS Y C
Sbjct: 207 TAVFTCK-TEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALE-KADSDTYTC-- 262
Query: 909 SNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKE 966
G++ A++ + +V ++ L+ + +EG + C+ S + W+ +K
Sbjct: 263 --DIGQAQSRAQLLVQGRRVHIIEDLE-DVDVQEGSSATFRCRISPANYEPVHWFLDKTP 319
Query: 967 ISGMDHREI-IQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQD 1025
+ + EI Q G D G I DQ S L V E F R+L D
Sbjct: 320 LHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASAALRVTEKPSVFSRELTD 379
Query: 1026 FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEG 1085
+ E + L E ++ V W +DG+ ++ + GH +L I ++ D G
Sbjct: 380 ATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSA-RCQLSHEGHRAQLLITGATLQDSG 438
Query: 1086 EYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSE 1145
Y C ++ V V P L++ +V +G AT L+ A V+W +
Sbjct: 439 RYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGGAATLRCVLSSVAAPVKWCYGNNV 498
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEF 1205
++ + L +G +L + + D+G YSC G+ +A LTV F +L
Sbjct: 499 LRPGDKYSLRQEGAMLELVVRNLRPQDSGRYSCSFGDQTTSATLTVTALPAQFIGKLRNK 558
Query: 1206 ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
T A L E+ + V W K + D +++ L D L IR D E
Sbjct: 559 EATEGAT-ATLRCEL-SKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAE 616
Query: 1266 YTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQPNDEWIVN 1324
Y+CV + +++ L + P + R G+ TL + +A P EW
Sbjct: 617 YSCVCGEERTSASLTIR--PMPAHFIGRLRHQESIEGATATLRCELSKAAPV---EWRKG 671
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
+ ++ D L I + DAG Y CG +T+ P+
Sbjct: 672 RESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPA 725
Score = 128 bits (308), Expect = 3e-28
Identities = 135/568 (23%), Positives = 226/568 (39%), Gaps = 52/568 (9%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLV-AIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ +P F + K Q EG+ +L+C L A P + W E + + S+ +
Sbjct: 1072 VRALPARFIEDVKNQEAREGATAVLQCELSKAAP---VEWRKGSETLRGGDRYSLRQDGT 1128
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
C L+I + G Y+ V A+L + P + + LK+
Sbjct: 1129 R---CE-LQIHGLSVADTGEYSCVCGQERTSATLTV-------RALPARFTQDLKTKEAS 1177
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYT 804
+G + L ++ + + W K + ++ K DG + I V D G Y+
Sbjct: 1178 EGATATLQCEL--SKVAPVEWKKGPETLRDGGRYSLKQDGTRCELQI-HDLSVADAGEYS 1234
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
G TSA +TV A P F + E T L +++ +
Sbjct: 1235 CMC----GQERTSATLTVR------ALPARFTEGLRNEEAMEGATATLQCELSK--AAPV 1282
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
W + E + + + DG EL I + + D+G Y CV G+ A +T+
Sbjct: 1283 EWRKGLEALRDGDKYSLRQDGAVCELQIHGL-AMADNGVYSCVC----GQERTSATLTVR 1337
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXX 984
F++ ++ TE G TV L+C+ +W + D + Q+G
Sbjct: 1338 ALPARFIEDMRNQKATE-GATVTLQCKLRKAAPVEWRKGPNTLKDGDRYSLKQDGTSCEL 1396
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D G CI + + TS L V+ FI +++ E E A+L+ E+ S+
Sbjct: 1397 QIRGLVIADAGEYSCICEQERTSATLTVRALPARFIEDVRNHEATEGATAVLQCEL-SKA 1455
Query: 1045 ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
A V W + E ++ ++Y + G +L IR +V D GEY C+ E +A +TV
Sbjct: 1456 APVEWRKGSETLRDG-DRYSLRQDGTRCELQIRGLAVEDTGEYLCVCGQERTSATLTVRA 1514
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
LP I + NQ+ +G AT EL+K A V W K ++ DG + L+
Sbjct: 1515 LPARFIDNMTNQEAREGATATLHCELSK-VAPVEWRKGPETLR---------DGDRHSLR 1564
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
+ L+ G E+G+ C+ T +
Sbjct: 1565 -QENRLNPGGGGCSELGSCHCSPAWTAK 1591
Score = 108 bits (260), Expect = 2e-22
Identities = 106/460 (23%), Positives = 181/460 (39%), Gaps = 9/460 (1%)
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK---WYHNKKEISGMDHREI 975
ARV + V K L K+ E EG++ EC SH ++ W K + +
Sbjct: 2 ARVRVHDLHVGITKRL-KTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQA 60
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAI 1035
++GR D G + V+ + L+V+E I+ L+D V +
Sbjct: 61 TRQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVE 120
Query: 1036 LEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES 1095
L E++ V W +D + I+ K KYD G + L IR S+ D GEY+C +
Sbjct: 121 LRCELSRAGTPVHWLKDRKAIR-KSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASK 179
Query: 1096 CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLT 1155
TA + V E L N +V + A F + A V W K E++ S Q +
Sbjct: 180 STASLHVEEKANCFTEELTNLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPS 239
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAY 1215
+G +L I + D+ Y+C++G ++ A L V+ ++ L + + ++ +
Sbjct: 240 QEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATF 299
Query: 1216 LTVEIPDETLDVTWYKKKSVIEDTEKFTLISDV-KKRTLIIRKCTEDDQCEYTCVLLDAK 1274
P V W+ K+ + E + + L +R+ D D +
Sbjct: 300 RCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQR 359
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
++ L+ V E P + I G D+TL+ + P W + K ++
Sbjct: 360 ASAALR--VTEKPSVFSRELTDATITEGEDLTLVCETSTCDIPVC-WTKDGKTLRGSARC 416
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMN 1374
+ S + A L I D+G YK C + V ++
Sbjct: 417 QLSHEGHRAQLLITGATLQDSGRYKCEAGGACSSSIVRVH 456
Score = 85.4 bits (202), Expect = 2e-15
Identities = 145/663 (21%), Positives = 254/663 (38%), Gaps = 71/663 (10%)
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLT 1155
A V V +L I RL+ +V +G +FE L+ A W G + S+ Q T
Sbjct: 2 ARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQAT 61
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAY 1215
G+K L + + DAGE V A L V E L + + P D
Sbjct: 62 RQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGE-DVE 120
Query: 1216 LTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
L E+ V W K + I ++K+ ++ + L+IR + D EYTC + +KS
Sbjct: 121 LRCELSRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKS 180
Query: 1276 TTKLKVEVVE--FPPKIVDYEREYRIKRGSDV-TLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
T L VE F ++ + + E ++G+ V T ++ P W ++
Sbjct: 181 TASLHVEEKANCFTEELTNLQVE---EKGTAVFTCKTEH---PAATVTWRKGLLELRASG 234
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+PS + + LTI +E D+ Y + G A + + + + +I+E
Sbjct: 235 KHQPSQEGLTLRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGR-----RVHIIE- 284
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFR 1452
D +++ G+S + + W K T + N +
Sbjct: 285 DLEDVDV------QEGSSATFRCRISPANYEPVHWFLDK--TPLHANELNEIDAQPGGYH 336
Query: 1453 AYAVNEVDISDASETTEYYKVIKETKIQSPTV-EKP------LKNITTEPNEDIELTCIF 1505
+ ++ + D+ T Y++ + + V EKP L + T ED+ L C
Sbjct: 337 VLTLRQLALKDSG--TIYFEAGDQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCET 394
Query: 1506 GGVPQPKVTWYRDGKKLKTA---KATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
P V W +DGK L+ + + ++E +R YKC A G +
Sbjct: 395 STCDIP-VCWTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCEA----GGACS 449
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKV-GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
S +V + +PV E +K + G + V+ + P V W N L +Y+
Sbjct: 450 SSIVRVHARPVRF--QEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYS 506
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
+ + + ++ L+ S +Y S + G + TL V P++ G + +E +
Sbjct: 507 LRQEGAMLELVVRNLRPQDSGRY----SCSFGDQTTSATLTVTALPAQFIGKLRNKEAT- 561
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
+G + + K P W K ++ RD + YC+++ CE R
Sbjct: 562 ------------EGATATLRCELSKAAPVE--WRKGSETLRDGDRYCLRQDGAMCELQIR 607
Query: 1741 VIA 1743
+A
Sbjct: 608 GLA 610
Score = 36.7 bits (81), Expect = 0.91
Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 2/85 (2%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
++ L + G V+ C++ P + W + I+ SQ + + + +A LVIR
Sbjct: 105 IKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQKYDVVCEG-TMAMLVIRG 162
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTE 597
+DAG +TC + + AS E
Sbjct: 163 ASLKDAGEYTCEVEASKSTASLHVE 187
Score = 34.3 bits (75), Expect = 4.9
Identities = 19/88 (21%), Positives = 40/88 (45%), Gaps = 3/88 (3%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F+E +R + +G+TV +C++ + W + +K + + D + L IR
Sbjct: 1343 FIEDMRNQKATEGATVTLQCKLR--KAAPVEWRKGPNTLKDGDRYSLKQDGTS-CELQIR 1399
Query: 572 EVFPEDAGTFTCVAKNAAGFASSTTELI 599
+ DAG ++C+ + A+ T +
Sbjct: 1400 GLVIADAGEYSCICEQERTSATLTVRAL 1427
>AK095113-1|BAC04488.1| 903|Homo sapiens protein ( Homo sapiens cDNA
FLJ37794 fis, clone BRHIP3000488. ).
Length = 903
Score = 182 bits (444), Expect = 9e-45
Identities = 134/598 (22%), Positives = 267/598 (44%), Gaps = 25/598 (4%)
Query: 923 IDVEKVTFVKHLQKSYETEEGKTVILEC---QTSHTVSTKWYHNKKEIS---GMDHREII 976
++VE + +K L+ ET+ TV+ +C V W + + + ++
Sbjct: 229 VEVEAIRILKPLEDK-ETKVDTTVVFDCIMELKDPNVKMIWIKGTEPLRIQYSLGKYDVK 287
Query: 977 QEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAIL 1036
Q G D G+ V D+ S L V + +F+ +++ +V E+ A+
Sbjct: 288 QMGTKYMLVISNVNMNDAGIYSLSVGDKRMSAELTVLDEPLKFLGEMKPVKVTERQTAVF 347
Query: 1037 EVEINSETADVVWERDGEIIKPKKNKYDF--EKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
E+ ++ + + VW+ +G+ +K + +KY+ + G L I++ + D GE+S +
Sbjct: 348 EIRLSKKEPNFVWKFNGKELK-RDDKYEITVSEDGLTHTLKIKDARLSDSGEFSAEAGNL 406
Query: 1095 SCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQL 1154
A++T+ +P + ++ L+N +V + ++A E ELT D +RW KDG + +
Sbjct: 407 VQKAQLTIDRIPIKFVSNLKNVRVKERSRACLECELTSKDVTLRWKKDGQLLMHGTKYSM 466
Query: 1155 TIDGKKQKLKIYDCDLDDAGEY---SCEVGNSK---CTAILTVEEPSINFTLRLPEFILV 1208
+GK+ +L I D L D GEY + + G+ TAI+TVEE + + +
Sbjct: 467 NHEGKQAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAIVTVEERLATVKSGMSD-VHA 525
Query: 1209 PANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC 1268
+ A L V + DE ++ W K I D ++ LI + + +YT
Sbjct: 526 ATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGVQIVKQGAVHKLIFPSMGPEHEGKYTF 585
Query: 1269 VLLDAKSTTKLKV-EVVEFPPKIVDYEREYRI--KRGSDVTLLVDYQAFPQPNDEWIVNS 1325
+S + + + P +++ + I K G + V ++ P P W +
Sbjct: 586 RAKGTESEASVFIADPPTIDPSVLEALAAHAITVKVGHTAHIKVPFRGKPLPKVTWYKDG 645
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
+ + + A LTI D+G+ L+L+N+ G A +++++L+ P
Sbjct: 646 MEVTEEERVSMERGEDQALLTISNCVREDSGLILLKLKNDHGSATATLHLSVLEPPGFAS 705
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNL 1443
+P + ++ ++ I W+ P G + ++ Y+VE ++ + W+ V I T+ ++ L
Sbjct: 706 QPQVTDVTKEAVTITWNAPTQDGGAPVLGYIVERRKKGSNLWVPVNKDPIQGTKCTVDGL 765
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIEL 1501
++ Y FR AVN+ S + V+ + ++ P + + L +++ N I L
Sbjct: 766 LEDTEYEFRVIAVNKAGPGQPSVPSS--SVVAKDPVKPPGLVQDL-HVSDSSNSSISL 820
Score = 108 bits (259), Expect = 2e-22
Identities = 139/666 (20%), Positives = 259/666 (38%), Gaps = 41/666 (6%)
Query: 1218 VEIPDETLDVTWYKKKSVIE---DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
+E+ D + + W K + K+ + K L+I +D Y+ + D +
Sbjct: 257 MELKDPNVKMIWIKGTEPLRIQYSLGKYDVKQMGTKYMLVISNVNMNDAGIYSLSVGDKR 316
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
+ +L V ++ P K + + ++ + +PN W N K +K+
Sbjct: 317 MSAELTV--LDEPLKFLGEMKPVKVTERQTAVFEIRLSK-KEPNFVWKFNGKELKRDDKY 373
Query: 1335 KPSI--DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ ++ D + +L IK +D+G + N A + ++ + S + E
Sbjct: 374 EITVSEDGLTHTLKIKDARLSDSGEFSAEAGNLVQKAQLTIDRIPIKFVSNLKNVRVKER 433
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK-TQTSIQNLKTNSSYRF 1451
+ + E E T + + + Q + S+ + K + I++ + + +
Sbjct: 434 SRACL-----ECELTSKDVTLRWKKDGQLLMHGTKYSMNHEGKQAELIIEDAQLSDGGEY 488
Query: 1452 RAYAVNEVDISDASETTEYYKV-IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
A+ + D TEYY I + + TV+ + ++ EL C+ +
Sbjct: 489 TVVAMQDGD------PTEYYSTAIVTVEERLATVKSGMSDVHAATGSPAEL-CVVLNDEK 541
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKC-IAFNDHGEVETSCVVGIQQ 1569
+ W +DGK++ + ++ F G E+ V I
Sbjct: 542 VEGVWLKDGKEITDLPGVQIVKQGAVHKLIFPSMGPEHEGKYTFRAKG-TESEASVFIAD 600
Query: 1570 KPVITISNEDIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE 1625
P I S + H KVG + G P P+V WYK+G ++ ++ ++ E
Sbjct: 601 PPTIDPSVLEALAAHAITVKVGHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGE 660
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+++ I R S ++ N G+++ + L V + P P + ++++E+VTI
Sbjct: 661 DQALLTISNCVREDSGLILLKLKNDHGSATATLHLSVLEPPGFASQPQV-TDVTKEAVTI 719
Query: 1686 EWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYC-IQKLNENCEYMFRVIAQ 1744
W P DGG + Y +E+ + +N W+ V + D T C + L E+ EY FRVIA
Sbjct: 720 TWNAPTQDGGAPVLGYIVERRKKGSNLWVPV-NKDPIQGTKCTVDGLLEDTEYEFRVIAV 778
Query: 1745 NPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G + ++ S +V K + P N S+ + W E G P Y
Sbjct: 779 NKAGPGQPSVPSSSVVAKDPVKPPGLVQDLHVSDS-SNSSISLAW--REPAEGDPPSGYI 835
Query: 1804 VEI-KQEGKKWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIG 1860
+E+ ++ K+W + L Y FRI A NE G P D +
Sbjct: 836 LEMWAEDTKEWSKCTKIPISGTCYTVGGLIERQKYFFRIRAVNEAGVGEPVELDKGV--- 892
Query: 1861 KTLTPP 1866
+ + PP
Sbjct: 893 RAMPPP 898
Score = 106 bits (255), Expect = 8e-22
Identities = 182/872 (20%), Positives = 319/872 (36%), Gaps = 76/872 (8%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKD-GSEIQFSNHIQLTIDGKKQKL 1163
PE++ + Q +G+KA F + +G+A + W ++ G I+ S I K+ L
Sbjct: 67 PELVEKPQPVTAPEGDKAVFRARV-QGNAKPHISWKRESGIPIKESAKIFYDSINKEHVL 125
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDE 1223
K+ DD+ Y C N AI TV ++ +
Sbjct: 126 KLEPLTSDDSDNYKCIASNDHADAIYTVS------------LLVTEGQEKMDFKKMLKKR 173
Query: 1224 TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK-LKVE 1282
K+K V + E ++S V K+ + C E ++ +L K K ++VE
Sbjct: 174 APPAPKKKQKKVANEKEMLEILSKVPKKDFE-KVCMEHGFTDFRGLLRKLKEMKKKVEVE 232
Query: 1283 VVEFPPKIVDYEREYRIKRGSDVTLLVD-YQAFPQPNDE--WIVNSKIIKKCKHTKPSID 1339
+ + D E + D T++ D PN + WI ++ ++ +++ D
Sbjct: 233 AIRILKPLEDKETKV------DTTVVFDCIMELKDPNVKMIWIKGTEPLR-IQYSLGKYD 285
Query: 1340 SKSAS----LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP---PGKP-NILE 1391
K L I V DAGIY L + G + +T+LD+P KP + E
Sbjct: 286 VKQMGTKYMLVISNVNMNDAGIYSLSV----GDKRMSAELTVLDEPLKFLGEMKPVKVTE 341
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYR 1450
++ I + E N + E + D E I+V T T I++ + + S
Sbjct: 342 RQTAVFEIRLSKKEP--NFVWKFNGKELKRDDKYE-ITVSEDGLTHTLKIKDARLSDSGE 398
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
F A A N V + + K + LKN+ + L C
Sbjct: 399 FSAEAGNLVQKAQLTIDRIPIKFVSN-----------LKNVRVKERSRACLECELTS-KD 446
Query: 1511 PKVTWYRDGKKLKTAKATYEN----RXXXXXXXXXXXXXXXYKCIAFNDHGEVE--TSCV 1564
+ W +DG+ L N + Y +A D E ++ +
Sbjct: 447 VTLRWKKDGQLLMHGTKYSMNHEGKQAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAI 506
Query: 1565 VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
V ++++ + T+ + + H V+ E +W K+G ++ + I +
Sbjct: 507 VTVEER-LATVKS-GMSDVHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGVQIVKQ 564
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + H KYT A T +SV + PS E + T
Sbjct: 565 GAVHKLIFPSMGPEHEGKYTFRAKGTESEASVFIADPPTIDPSVLEALAAHAITVKVGHT 624
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
K P L + + E + + + D I + + +
Sbjct: 625 AHIKVPFRGKPLPKVTWYKDGMEVTEEERVSM-ERGEDQALLTISNCVREDSGLILLKLK 683
Query: 1745 NPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKV 1804
N G + A + ++ P + E+V ITW ++GG+P++ Y V
Sbjct: 684 NDHGSATA------TLHLSVLEPPGFASQPQVTDVTKEAVTITWNAPTQDGGAPVLGYIV 737
Query: 1805 EIKQEGKK-WKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK 1861
E +++G W + + L +T Y+FR+ A N+ G P +
Sbjct: 738 ERRKKGSNLWVPVNKDPIQGTKCTVDGLLEDTEYEFRVIAVNKAGPGQPSVPSSSVVAKD 797
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
+ PP ++ VS+S++ S++L W EP G P + YI+E K W+K + S
Sbjct: 798 PVKPPGLVQDLHVSDSSNSSISLAWREPAE--GDPPSGYILEMWAEDTKEWSKCTKIPIS 855
Query: 1922 VHEHCIENIKEKDEIIFRISAENTVGVSLPTE 1953
+ + + E+ + FRI A N GV P E
Sbjct: 856 GTCYTVGGLIERQKYFFRIRAVNEAGVGEPVE 887
Score = 93.9 bits (223), Expect = 6e-18
Identities = 118/524 (22%), Positives = 215/524 (41%), Gaps = 51/524 (9%)
Query: 728 KTGEKEPPQVIEPLKSMIVRQGESVILSAQV-VGNPRPTITWCKNNKPVKALPTKSDGD- 785
K E E ++++PL+ + +V+ + + +P + W K +P++ + D
Sbjct: 227 KKVEVEAIRILKPLEDKETKVDTTVVFDCIMELKDPNVKMIWIKGTEPLRIQYSLGKYDV 286
Query: 786 ----THSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE 841
T + ++ + D G+Y+L S G SA +TV + EP F+ +
Sbjct: 287 KQMGTKYMLVISNVNMNDAGIYSL----SVGDKRMSAELTVLD------EPLKFLGEMKP 336
Query: 842 ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET--ITQNFDGENIELVITNVDSEI 899
+ V E+ T R+++ P+ W N + + + IT + DG L I +
Sbjct: 337 VKVTERQTAVFEIRLSKKE-PNFVWKFNGKELKRDDKYEITVSEDGLTHTLKIKDARLS- 394
Query: 900 DSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQ-TSHTVST 958
DSG++ A N K A++TID + FV +L K+ +E LEC+ TS V+
Sbjct: 395 DSGEFSAEAGNLVQK----AQLTIDRIPIKFVSNL-KNVRVKERSRACLECELTSKDVTL 449
Query: 959 KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI-VKDQE-----TSTMLVV 1012
+W + + + + EG+ D G + ++D + ++ ++ V
Sbjct: 450 RWKKDGQLLMHGTKYSMNHEGKQAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAIVTV 509
Query: 1013 KETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
+E + + D A L V +N E + VW +DG+ I K+G +
Sbjct: 510 EERLATVKSGMSDVHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPG-VQIVKQGAVH 568
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTVVELP---PEIITRLQNQ--KVNKGNKATFE 1127
KL + EG+Y+ + A V + + P P ++ L V G+ A +
Sbjct: 569 KLIFPSMGPEHEGKYTFRAKGTESEASVFIADPPTIDPSVLEALAAHAITVKVGHTAHIK 628
Query: 1128 IELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKC 1185
+ +G L V W+KDG E+ + + + L I +C +D+G ++ N
Sbjct: 629 VPF-RGKPLPKVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSGLILLKLKNDHG 687
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+A T+ L P F P TD + E + +TW
Sbjct: 688 SATATLHLS----VLEPPGFASQPQVTD------VTKEAVTITW 721
Score = 83.8 bits (198), Expect = 6e-15
Identities = 51/204 (25%), Positives = 86/204 (42%), Gaps = 2/204 (0%)
Query: 1863 LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
L PP V++ T +VT+ W P +GG+P+ YI+E + W +
Sbjct: 698 LEPPGFASQPQVTDVTKEAVTITWNAPTQDGGAPVLGYIVERRKKGSNLWVPVNKDPIQG 757
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNI 1982
+ ++ + E E FR+ A N G P+ S + K P L + ++
Sbjct: 758 TKCTVDGLLEDTEYEFRVIAVNKAGPGQPSVPSSSVVAKDPVKPPGLVQDLHVSDSSNSS 817
Query: 1983 VMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+ +W P G P GY + + W + K+ ++ + + L E Y RI
Sbjct: 818 ISLAWREPA--EGDPPSGYILEMWAEDTKEWSKCTKIPISGTCYTVGGLIERQKYFFRIR 875
Query: 2043 ARNEIGLSEPLESDEPFKVIPGEG 2066
A NE G+ EP+E D+ + +P G
Sbjct: 876 AVNEAGVGEPVELDKGVRAMPPPG 899
Score = 61.7 bits (143), Expect = 3e-08
Identities = 77/327 (23%), Positives = 131/327 (40%), Gaps = 18/327 (5%)
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
++ IP F K V E S LEC L + + + W G+ ++ S+ E
Sbjct: 414 IDRIPIKFVSNLKNVRVKERSRACLECELTS-KDVTLRWKKDGQLLMHGTKYSMNHEGKQ 472
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ L I + + G YTVVA+ ++G+ + I T E+ V + +
Sbjct: 473 ----AELIIEDAQLSDGGEYTVVAM-QDGDPTEYYSTAIVTVEERLATVKSGMSDVHAAT 527
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTL 805
G L V+ + + W K+ K + LP G H + I + EG YT
Sbjct: 528 GSPAELCV-VLNDEKVEGVWLKDGKEITDLPGVQIVKQGAVHKL-IFPSMGPEHEGKYTF 585
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+A+ +E A +V + PT + + L ITVK T + P+P +T
Sbjct: 586 RAKGTESEA---SVFIADPPTIDPSV--LEALAAHAITVKVGHTAHIKVPFRGKPLPKVT 640
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
WY++ ++ E ++ + L I+N E DSG N G ++ +++ +
Sbjct: 641 WYKDGMEVTEEERVSMERGEDQALLTISNCVRE-DSGLILLKLKNDHGSATATLHLSV-L 698
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQT 952
E F Q + T+E T+ T
Sbjct: 699 EPPGFASQPQVTDVTKEAVTITWNAPT 725
Score = 56.0 bits (129), Expect = 1e-06
Identities = 31/107 (28%), Positives = 48/107 (44%), Gaps = 2/107 (1%)
Query: 1948 VSLPTESQSVRLEKHATVPSPP--TAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAI 2005
+ L + S H +V PP + ++ V V +W P DGGAP+LGY +
Sbjct: 680 LKLKNDHGSATATLHLSVLEPPGFASQPQVTDVTKEAVTITWNAPTQDGGAPVLGYIVER 739
Query: 2006 RDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
R +W+ V K + K + L E+ Y R+ A N+ G +P
Sbjct: 740 RKKGSNLWVPVNKDPIQGTKCTVDGLLEDTEYEFRVIAVNKAGPGQP 786
Score = 50.8 bits (116), Expect = 5e-05
Identities = 30/93 (32%), Positives = 48/93 (51%), Gaps = 4/93 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAI-IKPSQDFQMYYDDDNVA-T 567
P VEK +P P+G F +V+G +P I+W R++ I IK S +++YD N
Sbjct: 67 PELVEKPQPVTAPEGDKAVFRARVQGNAKPHISWKRESGIPIKESA--KIFYDSINKEHV 124
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
L + + +D+ + C+A N A T L+V
Sbjct: 125 LKLEPLTSDDSDNYKCIASNDHADAIYTVSLLV 157
Score = 49.6 bits (113), Expect = 1e-04
Identities = 46/158 (29%), Positives = 67/158 (42%), Gaps = 7/158 (4%)
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE 841
S TH T + K+ E V K S I E +++T P + + Q
Sbjct: 19 SSSTTHVQTFSQTTKIVGEEVVRRK---SSSIVEFFSLVTRSSNIPAGDSVPELVEKPQP 75
Query: 842 ITVKEKGTIKLVARVTRNPVPSITWYRNNEI-ISPSETITQNFDGENIELVITNVDSEID 900
+T E ARV N P I+W R + I I S I + + L + + S+ D
Sbjct: 76 VTAPEGDKAVFRARVQGNAKPHISWKRESGIPIKESAKIFYDSINKEHVLKLEPLTSD-D 134
Query: 901 SGDYKCVASNSAGKSSH--GARVTIDVEKVTFVKHLQK 936
S +YKC+ASN + + VT EK+ F K L+K
Sbjct: 135 SDNYKCIASNDHADAIYTVSLLVTEGQEKMDFKKMLKK 172
Score = 46.0 bits (104), Expect = 0.001
Identities = 45/196 (22%), Positives = 86/196 (43%), Gaps = 15/196 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P F + K V E + E RL + EP+ W F G+E+ D+ + + D +
Sbjct: 327 PLKFLGEMKPVKVTERQTAVFEIRL-SKKEPNFVWKFNGKELKRDDKYEITVSEDGLTH- 384
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
LKI + + G ++ A N +A L I ++ P + + LK++ V++
Sbjct: 385 -TLKIKDARLSDSGEFSAEAGNLVQKAQLTI-------DRIPIKFVSNLKNVRVKERSRA 436
Query: 753 ILSAQVVGNPRPTITWCKNNKPVK--ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
L ++ T+ W K+ + + + + + I++ ++ D G YT+ A
Sbjct: 437 CLECELTSKD-VTLRWKKDGQLLMHGTKYSMNHEGKQAELIIEDAQLSDGGEYTVVAMQD 495
Query: 811 EGIAE--TSAVITVEE 824
E ++A++TVEE
Sbjct: 496 GDPTEYYSTAIVTVEE 511
Score = 39.5 bits (88), Expect = 0.13
Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 1/80 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G T + G P P++TW++ + + M +D A L I ED+G
Sbjct: 622 GHTAHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQ-ALLTISNCVREDSGLILL 680
Query: 584 VAKNAAGFASSTTELIVEAP 603
KN G A++T L V P
Sbjct: 681 KLKNDHGSATATLHLSVLEP 700
>AJ306906-1|CAC37630.1| 2673|Homo sapiens fibulin-6 protein.
Length = 2673
Score = 181 bits (441), Expect = 2e-44
Identities = 232/1072 (21%), Positives = 401/1072 (37%), Gaps = 85/1072 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P K + V + I L C + P PD++WL K E+ + ++ +
Sbjct: 2 PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWL-KNEQPIKLNTNTLIVPGGR---- 56
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L+I K G YT +A+N+ GE+ L + E L + VR+G SV
Sbjct: 57 -TLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSV 115
Query: 753 ILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
L + P P ITW KN + + ++ + D + I K +V D G Y +A N
Sbjct: 116 SLEXESNAVPPPVITWYKNGRMITESTHVEILADGQMLHI-KKAEVSDTGQYVCRAINVA 174
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKE-KGTIKLVARVTRNPVPSITWYRNN 870
G + + + V PP +E+ V+ + L T P P+I W +N+
Sbjct: 175 GRDDKNFHLNV-------YVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNH 227
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
+ I S+++ +L I DSG+Y C+ASN GK+ ++I V
Sbjct: 228 KRIENSDSLEVRILSGGSKLQIAR-SQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVA 286
Query: 931 VKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ G+ V L C + T +W + K I+ + I
Sbjct: 287 GAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYG 346
Query: 989 XXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE--- 1043
D G C+ + E + + + IR +D EK + +++ IN E
Sbjct: 347 ALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKD--EAEKLMTLVDTSINIECRA 404
Query: 1044 ----TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
+ W ++G + P + G + + I V D Y+C+ + +
Sbjct: 405 TGTPPPQINWLKNG-LPLPLSSHIRLLAAGQV--IRIVRAQVSDVAVYTCVASNRAGVDN 461
Query: 1100 V---TVVELPPEIITRLQNQKVN--KGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHI 1152
V PP + + +++ KG+ + +T G + W +DG + H
Sbjct: 462 KHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC-ITDGTPAPSMAWLRDGQPLGLDAH- 519
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPSINFTLRLPEFIL 1207
LT+ L++ + +D+G+Y+C N SK + +E P IN + E +
Sbjct: 520 -LTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISV 578
Query: 1208 VPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ N + +TW K + T++ + L I +D YT
Sbjct: 579 IVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGG--GEVLRISTAQVEDTGRYT 636
Query: 1268 CVLLD-AKSTTKLKVEVVEFPPKI--VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
C+ A K + V PP I D R+ + R VTL A P P W+ N
Sbjct: 637 CLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRN 696
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+ ++ + I S L I + D Y N G E +T+ P+
Sbjct: 697 GERLQATPRVR--ILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIK 754
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLK 1444
G P L I +N ST++ + E W + + ++
Sbjct: 755 GGPQSLVI---LLN----------KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL 801
Query: 1445 TNSSYRFRAYAVNEVD----ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
N ++ V + ++ + T+ ++ + + P++ N+T N
Sbjct: 802 ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHV-PPSIAPGPTNMTVIVNVQTT 860
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXX----XXXXXXXXXYKCIAFNDH 1556
L C G+P+P + W ++G L + R Y+C N
Sbjct: 861 LACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGA 920
Query: 1557 GEVETSCVVGIQQKPVITISNED-IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK-LE 1614
G+ + + + +Q P I D + KH ++T G+P P + W KNG + L
Sbjct: 921 GDDKRTVDLTVQVPPSIADEPTDFLVTKHAPA---VITCTASGVPFPSIHWTKNGIRLLP 977
Query: 1615 NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
Y I + + I I + +H+ +YT A N AG++ VTL V++ P
Sbjct: 978 RGDGYRILS---SGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP 1026
Score = 164 bits (399), Expect = 3e-39
Identities = 241/1072 (22%), Positives = 409/1072 (38%), Gaps = 79/1072 (7%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP+ + + P V G ++ L C IP P I WL G+ I E + + ++
Sbjct: 281 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG- 339
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
S L I G YT VA N GE L + E K M +
Sbjct: 340 ---STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD- 395
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ + + G P P I W KN P+ + + +V D VYT A N
Sbjct: 396 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 455
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G+ + V P N + + +EITV + + + P PS+ W R+
Sbjct: 456 RAGVDNKHYNLQVFAPP--NMDNSMGT---EEITVLKGSSTSMACITDGTPAPSMAWLRD 510
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + +T + G ++L+ + DSG Y C+ASN AG+ S + KV
Sbjct: 511 GQPLGLDAHLTVSTHGMVLQLLKAETE---DSGKYTCIASNEAGEVSKHF-----ILKVL 562
Query: 930 FVKHLQKSYETEEGKTVI-----LECQTSHTVSTK--WYHNKKEISGMDHREIIQEGRXX 982
H+ S E EE ++ L C S + K W + + + D + + G
Sbjct: 563 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVL 622
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILE 1037
D G C+ + +V+ +P I + +D V LE
Sbjct: 623 RISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLE 680
Query: 1038 VEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES- 1095
+ ++ V+ W R+GE ++ + G R L I N + D Y+C+ + +
Sbjct: 681 CKSDAVPPPVITWLRNGERLQATP-RVRILSGG--RYLQINNADLGDTANYTCVASNIAG 737
Query: 1096 -CTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNH 1151
T E + V +PP I Q+ + NK+T + +G R W KDG+ + NH
Sbjct: 738 KTTREFILTVNVPPNIKGGPQSLVILL-NKSTVLECIAEGVPTPRITWRKDGAVLA-GNH 795
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFI 1206
+ +I + L I + D G Y C N+ T ++ PSI P +
Sbjct: 796 ARYSIL-ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSI---APGPTNM 851
Query: 1207 LVPANTDAYLTVE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQ 1263
V N L E IP +++ W K ++ + + +L+I + DD
Sbjct: 852 TVIVNVQTTLACEATGIPKPSIN--WRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDT 909
Query: 1264 CEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
Y C + + K V++ V+ PP I D ++ + + + + P P+ W
Sbjct: 910 ATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT 969
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N I+ S ++ I + AG Y N G A + + + + P
Sbjct: 970 KNG--IRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPV 1027
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
+P+ L + ++ + E T + I + E I+V + + +
Sbjct: 1028 IQPQPSELHVILNNPILLPCEATGTPSPFITWQ---------KEGINVNTSGRNHAVLPS 1078
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP-LKNITTEPNEDIEL 1501
S R A + ++ T K+ + +Q P V P LK ++ I L
Sbjct: 1079 GGLQISRAVREDAGTYMCVAQNPAGTALGKI--KLNVQVPPVISPHLKEYVIAVDKPITL 1136
Query: 1502 TCIFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+C G+P P +TW++DG+ + ++ + + Y C+A N G
Sbjct: 1137 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQITFVQPGDAGHYTCMAANVAGSSS 1196
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
TS + + P I S E ++ + ++ V +GIP P + W K+ L N
Sbjct: 1197 TSTKLTVHVPPRIR-STEGHYTVNE-NSQAILPCVADGIPTPAINWKKDNVLLAN--LLG 1252
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
T E + ++ + S YT A+N AG + V+L V+ P+ E P
Sbjct: 1253 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELP 1304
Score = 152 bits (368), Expect = 2e-35
Identities = 240/1167 (20%), Positives = 421/1167 (36%), Gaps = 118/1167 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS+ C +G P P + W R + D + + L + + ED+G +TC
Sbjct: 488 GSSTSMACITDGTPAPSMAWLRDGQPL--GLDAHLTVSTHGMV-LQLLKAETEDSGKYTC 544
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
+A N AG S L V P +GSE I GIP PK
Sbjct: 545 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIP-----APKMT 599
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
++ +G +P+ D G E VL+I+ +
Sbjct: 600 WMKDGR---------PLPQTDQVQTLGGGE--------------------VLRISTAQVE 630
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI---EPLKSMIVRQGESVILSAQVVG 760
G YT +A + G+ ++++ PP + EP + + V + V L +
Sbjct: 631 DTGRYTCLASSPAGDDDKEYLVRVHV----PPNIAGTDEP-RDITVLRNRQVTLECKSDA 685
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
P P ITW +N + ++A P + + D YT A N G ++
Sbjct: 686 VPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 745
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV P P + I + + ++ +A P P ITW ++ +++ +
Sbjct: 746 TVNVPPNIKGGPQSLV-----ILLNKSTVLECIAEGV--PTPRITWRKDGAVLAGNHARY 798
Query: 881 QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET 940
+ + + +V D+G Y C+A+N+AG + + V +
Sbjct: 799 SILENGFLHIQSAHV---TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIV 855
Query: 941 EEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
T+ E S W N ++ ++ + D +C
Sbjct: 856 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 915
Query: 1001 VKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEII 1056
V + + T+ + + P + DF V + A++ + + W ++G +
Sbjct: 916 VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRL 975
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA--EVTV-VELPPEIITRL 1113
P+ + Y G I I T ++ G Y+C+ R+ + +A VT+ V PP I +
Sbjct: 976 LPRGDGYRILSSGAIE---ILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 1032
Query: 1114 QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDL 1170
V N E T + W K+G + S NH L G L+I
Sbjct: 1033 SELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG----LQISRAVR 1088
Query: 1171 DDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL- 1225
+DAG Y C N TA+ L V+ P + + L E+++ D +T+ + L
Sbjct: 1089 EDAGTYMCVAQNPAGTALGKIKLNVQVPPV-ISPHLKEYVIA---VDKPITLSCEADGLP 1144
Query: 1226 --DVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLK 1280
D+TW+K ++++E + L S + T + D YTC+ + S+T K
Sbjct: 1145 PPDITWHKDGRAIVESIRQRVLSSGSLQITFV----QPGDAGHYTCMAANVAGSSSTSTK 1200
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC--KHTKPSI 1338
+ V PP+I E Y + S L P P W ++ ++ K+T
Sbjct: 1201 L-TVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTA--- 1256
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
L ++ V D+G Y N G +++T+ P+ P
Sbjct: 1257 -EPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG---------- 1305
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
D N G + + W NI N + + +
Sbjct: 1306 ---DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 1362
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEK-PLKNITTEP-NEDIELTCIFGGVPQPKVTWY 1516
+ A + + K I ++ P V K + EP + L C G P P + W
Sbjct: 1363 TYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSHWIEPLGGNAILNCEVKGDPTPTIQWN 1422
Query: 1517 RDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
R G ++ + + Y C+A N+ G VE S + +Q P+IT+
Sbjct: 1423 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 1482
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKEL 1635
E ++ G + ++ G P P + W + G+ + D N+ + + I +
Sbjct: 1483 --EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS---LYIADA 1537
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ +S++ A N G+ V V + V
Sbjct: 1538 QKEDTSEFECVARNLMGSVLVRVPVIV 1564
Score = 130 bits (313), Expect = 7e-29
Identities = 150/649 (23%), Positives = 250/649 (38%), Gaps = 54/649 (8%)
Query: 1072 RKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEIITR----LQNQKVNKGNKA 1124
R L I V D GEY+CI +++ ++ V +PP I L V +G
Sbjct: 56 RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSV 115
Query: 1125 TFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN- 1182
+ E E ++ W+K+G I S H+++ DG Q L I ++ D G+Y C N
Sbjct: 116 SLEXESNAVPPPVITWYKNGRMITESTHVEILADG--QMLHIKKAEVSDTGQYVCRAINV 173
Query: 1183 ----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVE---IPDETLDVTWYKKKSV 1235
K + PSI R E I+ + LT + IP T + W K
Sbjct: 174 AGRDDKNFHLNVYVPPSIEGPER--EVIVETISNPVTLTCDATGIPPPT--IAWLKNHKR 229
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT-KLKVEVVEFPPKIVDYE 1294
IE+++ + L I + D YTC+ + + K ++ PP + E
Sbjct: 230 IENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 289
Query: 1295 --REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
+ + G +V L+ + P P +W+ + K I + + + + ++L I
Sbjct: 290 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 349
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN----ILEIDSSSINICWDEPENTG 1408
+D G Y N G D N+ + P+ G + ++ + +SINI E TG
Sbjct: 350 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINI---ECRATG 406
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETT 1468
W+ + I+ L R V++V + +
Sbjct: 407 TPP-----------PQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 455
Query: 1469 EYYKVIKETKIQ---SPTVEKPL--KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
K +Q P ++ + + IT + CI G P P + W RDG+ L
Sbjct: 456 RAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLG 515
Query: 1524 T-AKATYENRXXXXXXXXXXXXXXX-YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK 1581
A T Y CIA N+ GEV ++ + + P I S E +
Sbjct: 516 LDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEE 575
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
V + +T + GIP P++ W K+G L + + T V+RI + +
Sbjct: 576 ISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ--VQTLGGGEVLRISTAQVEDTG 633
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKP--SKPEGPVIMREISRESVTIEWK 1688
+YT AS+ AG E ++V+ P + + P + + VT+E K
Sbjct: 634 RYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECK 682
Score = 126 bits (303), Expect = 1e-27
Identities = 175/887 (19%), Positives = 314/887 (35%), Gaps = 59/887 (6%)
Query: 832 PPLFIN-RFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
PP I + + +TV I L V+ P P ++W +N + I + G +++
Sbjct: 1 PPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI 60
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYET---EEGKTVI 947
+ V D G+Y C+A N AG+S +T+ V + H +S EG +V
Sbjct: 61 IRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPP-SIKDHDSESLSVVNVREGTSVS 116
Query: 948 LECQTSHTVST--KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV---K 1002
LE +++ WY N + I+ H EI+ +G+ V + I +
Sbjct: 117 LEXESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGR 176
Query: 1003 DQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNK 1062
D + + V E + E V + + W ++ + I+ +
Sbjct: 177 DDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIE-NSDS 235
Query: 1063 YDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRLQNQKVN 1119
+ KL I + D G Y+CI + A+ +++PP + V+
Sbjct: 236 LEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVS 295
Query: 1120 KGNKATFEIELTKGDA---LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY 1176
E+ L++W KDG I ++ + L IY D G+Y
Sbjct: 296 VLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKY 355
Query: 1177 SCEVGN-----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTWY 1230
+C N + + P+I E ++ +T + + W
Sbjct: 356 TCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWL 415
Query: 1231 KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
K + + L++ + + I + D YTCV + + F P
Sbjct: 416 KNGLPLPLSSHIRLLA--AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPN 473
Query: 1291 VDYE---REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
+D E + +GS ++ P P+ W+ + + + H ++ + L +
Sbjct: 474 MDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL--TVSTHGMVLQL 531
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENT 1407
K E D+G Y N G + +L+ P G EI S +N N
Sbjct: 532 LKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI-SVIVN-------NP 583
Query: 1408 GNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD------I 1461
T I + ++ W+ +Q L R V +
Sbjct: 584 LELTCIASGIPAPKMT---WMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLAS 640
Query: 1462 SDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKK 1521
S A + + Y V ++P ++IT N + L C VP P +TW R+G++
Sbjct: 641 SPAGDDDKEYLVRVHVPPNIAGTDEP-RDITVLRNRQVTLECKSDAVPPPVITWLRNGER 699
Query: 1522 LKTAKAT--YENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNED 1579
L+ Y C+A N G+ ++ + P I +
Sbjct: 700 LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQS 759
Query: 1580 IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRIKELKRS 1638
+ + ++ + EG+P P + W K+G L N Y+I + + I+ +
Sbjct: 760 LVIL--LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL---ENGFLHIQSAHVT 814
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+ +Y A+N AGT + L+V+ PS GP M I T+
Sbjct: 815 DTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTL 861
Score = 121 bits (291), Expect = 3e-26
Identities = 205/965 (21%), Positives = 343/965 (35%), Gaps = 83/965 (8%)
Query: 632 IPPTFS--KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PP + +P+ V + LEC+ A+P P I WL GE + + +
Sbjct: 656 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGG--- 712
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I N YT VA N G+ + +L + PP + +S+++
Sbjct: 713 ---RYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PPNIKGGPQSLVILLN 765
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+S +L G P P ITW K+ + + + ++ V D G Y A N
Sbjct: 766 KSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATN 825
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ G + V P P +TV L T P PSI W +N
Sbjct: 826 AAGTDRRRIDLQVHVPPSIAPGPT-------NMTVIVNVQTTLACEATGIPKPSINWRKN 878
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+++ + + LVI + + D+ Y+C +N AG +T+ V
Sbjct: 879 GHLLNVDQNQNSYRLLSSGSLVIISPSVD-DTATYECTVTNGAGDDKRTVDLTVQVPPS- 936
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ + + ++ C S + K I + + +
Sbjct: 937 -IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 995
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIR-KLQDFEVKEKDVAILEVEINSETAD 1046
G C+ ++ S V + P I+ + + V + +L E +
Sbjct: 996 QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSP 1055
Query: 1047 -VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV--- 1102
+ W+++G + + G ++ I D G Y C+ ++ + TA +
Sbjct: 1056 FITWQKEGINVNTSGRNHAVLPSGGLQ---ISRAVREDAGTYMCVAQNPAGTALGKIKLN 1112
Query: 1103 VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL----VRWFKDGSEIQFSNHIQLTIDG 1158
V++PP I L+ + T E D L + W KDG I S ++ G
Sbjct: 1113 VQVPPVISPHLKEYVIAVDKPITLSCE---ADGLPPPDITWHKDGRAIVESIRQRVLSSG 1169
Query: 1159 KKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPE-FILVPANTD 1213
L+I DAG Y+C G+S + LTV P +R E V N+
Sbjct: 1170 S---LQITFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPP---RIRSTEGHYTVNENSQ 1223
Query: 1214 AYLT-VEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V T + W K ++ + K+T LI+ +D YTCV
Sbjct: 1224 AILPCVADGIPTPAINWKKDNVLLANLLGKYTA---EPYGELILENVVLEDSGFYTCVAN 1280
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+A V + V P + + + +G + L P P W N+ II
Sbjct: 1281 NAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA 1340
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
H S++ S L I++V D+G Y EN+ G V + + P +
Sbjct: 1341 --HFD-SVNGHS-ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP-------VF 1389
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ D S W EP G + I+ V+ T +W + I+ L S
Sbjct: 1390 KGDYPS---HWIEP--LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS--- 1441
Query: 1451 FRAYAVNEVDISD-ASETTEYYKVIKET---KIQSPTV--EKPLKNITTEPNEDIELTCI 1504
Y D D T V++ + +QSP + +P++ + + I L C
Sbjct: 1442 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGK-IILNCQ 1500
Query: 1505 FGGVPQPKVTWYRDGKKLK-TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
G PQP +TW R G + + + ++C+A N G V
Sbjct: 1501 ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRV 1560
Query: 1564 VVGIQ 1568
V +Q
Sbjct: 1561 PVIVQ 1565
Score = 110 bits (264), Expect = 6e-23
Identities = 155/756 (20%), Positives = 283/756 (37%), Gaps = 49/756 (6%)
Query: 960 WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIP 1017
W N++ I + I+ GR D G CI +Q E+ + +P
Sbjct: 36 WLKNEQPIKLNTNTLIVPGGRTLQIIRAKVS--DGGEYTCIAINQAGESKKKFSLTVYVP 93
Query: 1018 EFIR-----KLQDFEVKEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHI 1071
I+ L V+E LE E N+ V+ W ++G +I + E
Sbjct: 94 PSIKDHDSESLSVVNVREGTSVSLEXESNAVPPPVITWYKNGRMITESTH---VEILADG 150
Query: 1072 RKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNK-GNKATFE 1127
+ L+I+ V D G+Y C + + + V +PP I + V N T
Sbjct: 151 QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLT 210
Query: 1128 IELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT 1186
+ T + W K+ I+ S+ +++ I KL+I D+G Y+C N +
Sbjct: 211 CDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGK 270
Query: 1187 A----ILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEK 1241
A L+++ P +P + V + L T + W K I E
Sbjct: 271 AQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGET 330
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRI 1299
+ TL I D +YTCV + + + V P + + ++
Sbjct: 331 ERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKL 390
Query: 1300 KRGSDVTLLVDYQAF--PQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGI 1357
D ++ ++ +A P P W+ N + H + + + + I + + +D +
Sbjct: 391 MTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIR--LLAAGQVIRIVRAQVSDVAV 448
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPP---GKPNILEIDSSSINICWDEPENTGNSTIIY 1414
Y N G + N+ + P+ G I + SS ++ S +
Sbjct: 449 YTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPS--MA 506
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYY--K 1472
++ + Q + ++V + +T S ++ A NE A E ++++ K
Sbjct: 507 WLRDGQPLGLDAHLTVSTHGMV-LQLLKAETEDSGKYTCIASNE-----AGEVSKHFILK 560
Query: 1473 VIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYE 1530
V++ I + + I P +ELTCI G+P PK+TW +DG+ L T
Sbjct: 561 VLEPPHINGSEEHEEISVIVNNP---LELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLG 617
Query: 1531 NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEW 1590
Y C+A + G+ + +V + P I ++E +
Sbjct: 618 GGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQV 677
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
+ + +PPP + W +NG +L+ I + + ++I ++ YT ASN
Sbjct: 678 TLECKSDAVPPPVITWLRNGERLQATPRVRILSGGR--YLQINNADLGDTANYTCVASNI 735
Query: 1651 AGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
AG ++ E L V P+ GP + + +S +E
Sbjct: 736 AGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLE 771
Score = 48.8 bits (111), Expect = 2e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 7/95 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV-ATL 568
P F E G ++ C+ G P P++TW II P+ ++D N + L
Sbjct: 1298 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII-PA-----HFDSVNGHSEL 1351
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
VI V ED+GT+ C A+N+ GF + + V+ P
Sbjct: 1352 VIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 1386
Score = 47.6 bits (108), Expect = 5e-04
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 6/88 (6%)
Query: 518 PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFP 575
P H P G C+V+G P P I W R+ I+ S + + +L I
Sbjct: 1394 PSHWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN----GSLAIYGTVN 1449
Query: 576 EDAGTFTCVAKNAAGFASSTTELIVEAP 603
EDAG +TCVA N AG + L +++P
Sbjct: 1450 EDAGDYTCVATNEAGVVERSMSLTLQSP 1477
Score = 47.2 bits (107), Expect = 6e-04
Identities = 41/146 (28%), Positives = 57/146 (39%), Gaps = 5/146 (3%)
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
E L + +G++V E + P P ITW++ +I S ++ D L I++
Sbjct: 102 ESLSVVNVREGTSVSLEXESNAVPPPVITWYKNGRMITESTHVEILADGQ---MLHIKKA 158
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
D G + C A N AG L V P S G E V D GIP
Sbjct: 159 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCD-ATGIP 217
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVA 659
P K E SD LE R+++
Sbjct: 218 PPTIAWLKNHKRIENSD-SLEVRILS 242
Score = 45.6 bits (103), Expect = 0.002
Identities = 46/194 (23%), Positives = 72/194 (37%), Gaps = 12/194 (6%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
+++ EC+ G P PQI W + + S ++ V +V +V D +TCV
Sbjct: 396 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRL-LAAGQVIRIVRAQV--SDVAVYTCV 452
Query: 585 AKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQY 644
A N AG + L V AP + S T A I +G P P +
Sbjct: 453 ASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTP-----APSMAW 507
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI----ESDMHMYCSVLKITNV 700
+ +G + L+ L + L K E + +A E H VL+ ++
Sbjct: 508 LRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHI 567
Query: 701 KKFQEGTYTVVAVN 714
+E V VN
Sbjct: 568 NGSEEHEEISVIVN 581
Score = 45.2 bits (102), Expect = 0.003
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+ S C +G P P I W + ++ + Y + L++ V ED+G +T
Sbjct: 1220 ENSQAILPCVADGIPTPAINWKKDNVLLA---NLLGKYTAEPYGELILENVVLEDSGFYT 1276
Query: 583 CVAKNAAGFASSTTELIV 600
CVA NAAG + T L V
Sbjct: 1277 CVANNAAGEDTHTVSLTV 1294
Score = 45.2 bits (102), Expect = 0.003
Identities = 38/185 (20%), Positives = 69/185 (37%), Gaps = 4/185 (2%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
PT + +++ E + L+C G+P PK+TW + + +
Sbjct: 1298 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 1357
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A N G V+ V +++ PV + +G ++ ++G P
Sbjct: 1358 KEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFK-GDYPSHWIEPLGGNAILNCEVKGDPT 1416
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P + W + G +E + I S + I + YT A+N AG ++L
Sbjct: 1417 PTIQWNRKGVDIE--ISHRIRQLGNGS-LAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 1473
Query: 1662 VYDKP 1666
+ P
Sbjct: 1474 LQSPP 1478
Score = 44.4 bits (100), Expect = 0.005
Identities = 26/86 (30%), Positives = 39/86 (45%), Gaps = 5/86 (5%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
+ C+V G+P P ++W + IK + + + TL I D G +TC+A
Sbjct: 20 ISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIV---PGGRTLQIIRAKVSDGGEYTCIAI 76
Query: 587 NAAGFASSTTELIVEAP--LSDHGSE 610
N AG + L V P + DH SE
Sbjct: 77 NQAGESKKKFSLTVYVPPSIKDHDSE 102
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ + H + + C+ G P P ITW ++ + S L
Sbjct: 1026 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQ 1082
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP--LSDHGSEMTV 613
I EDAGT+ CVA+N AG A +L V+ P +S H E +
Sbjct: 1083 ISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 1128
Score = 42.3 bits (95), Expect = 0.018
Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + CQ G P+P ITW RQ I S D ++ +N +L I + ED F C
Sbjct: 1492 GGKIILNCQATGEPQPTITWSRQGHSI--SWDDRVNVLSNN--SLYIADAQKEDTSEFEC 1547
Query: 584 VAKNAAGFASSTTELIVE 601
VA+N G +IV+
Sbjct: 1548 VARNLMGSVLVRVPVIVQ 1565
Score = 40.7 bits (91), Expect = 0.056
Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 1/67 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G V+ C G P P I W + I S + + N +TL I D G +TC
Sbjct: 299 GENVELVCNANGIPTPLIQWLKDGKPIA-SGETERIRVSANGSTLNIYGALTSDTGKYTC 357
Query: 584 VAKNAAG 590
VA N AG
Sbjct: 358 VATNPAG 364
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 7/85 (8%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
KH P T C G P P I W + + P D + L + A
Sbjct: 948 KHAPAVIT----CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL---NHA 1000
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TCVA+NAAG A L V P
Sbjct: 1001 GRYTCVARNAAGSAHRHVTLHVHEP 1025
>AJ277892-3|CAD12457.1| 5604|Homo sapiens Novex-3 Titin Isoform
protein.
Length = 5604
Score = 181 bits (440), Expect = 3e-44
Identities = 176/746 (23%), Positives = 300/746 (40%), Gaps = 44/746 (5%)
Query: 795 KKVKDEGVYTLKA---ENSEGIAETSAV-ITVEEPTEENAEP----PLFINRFQEITVKE 846
+K KDE ++ K E + +AE + I +P + P P R Q TV +
Sbjct: 2032 RKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQ 2091
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENI-ELVITNVDSEIDSGDYK 905
RV P P WY+N I S+ I + +N+ ELVI +V +E DS
Sbjct: 2092 GSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAE-DSASIM 2150
Query: 906 CVASNSAGKSSHGARVTIDVEK-VTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHN 963
A N AG++S A + + ++ +TF + LQ E+ EC+TS V KWY +
Sbjct: 2151 VKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKD 2210
Query: 964 KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE---TSTMLVVKETIPEFI 1020
E+ D + + + D C++ + E T+ L+V+ + EF+
Sbjct: 2211 GMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFV 2270
Query: 1021 RKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTS 1080
++LQD EV E LE ++ E + W + +K KY R + L +++ +
Sbjct: 2271 KELQDIEVPESYSGELECIVSPENIEGKWYHNDVELK-SNGKYTITSRRGRQNLTVKDVT 2329
Query: 1081 VHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWF 1140
D+GEYS ++ + T ++ + P I+ L +QKV +G+ E++++ W
Sbjct: 2330 KEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWM 2389
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL 1200
KDG E+Q S+ + + ID + L I D +DAG YS + + V S++
Sbjct: 2390 KDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVIT 2449
Query: 1201 RLPEFILVPANTDAYL--TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
L + + V T A L V +PD T V WY I+ ++ I K+ L+I +
Sbjct: 2450 PLKD-VNVIEGTKAVLECKVSVPDVT-SVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRT 2507
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
D+ Y ++ ++ L VE + KI+ R+ +V V+ + +
Sbjct: 2508 HASDEGPYKLIVGRVETNCNLSVEKI----KIIRGLRDLTCTETQNVVFEVEL-SHSGID 2562
Query: 1319 DEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL 1378
W K IK K K LT+ + D G Y N + + +
Sbjct: 2563 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAGGAI 2622
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT 1438
KP + E + P++ G EW+
Sbjct: 2623 SKPLT--DQTVAESQEAVFECEVANPDSKG-----------------EWLRDGKHLPLTN 2663
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
+I++ R A DI + + K + K+++ ++K LKN+T +D
Sbjct: 2664 NIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2723
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKT 1524
T V W ++G L++
Sbjct: 2724 AVFTVELTHPNVKGVQWIKNGVVLES 2749
Score = 180 bits (437), Expect = 7e-44
Identities = 245/1076 (22%), Positives = 413/1076 (38%), Gaps = 92/1076 (8%)
Query: 645 VDEGSDILLECRLVAIPE-PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG+ +LEC+ V++P+ + W E+I PD+ + ++ L I
Sbjct: 2456 VIEGTKAVLECK-VSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQR----LVINRTHAS 2510
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
EG Y ++ E +L + KIK +I L+ + + ++V+ ++ +
Sbjct: 2511 DEGPYKLIVGRVETNCNLSVE-KIK--------IIRGLRDLTCTETQNVVFEVEL-SHSG 2560
Query: 764 PTITWC---KNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+ W K KP ++ G + +T+L K DEG YT A E I TS +
Sbjct: 2561 IDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMK-DDEGKYTFYA--GENI--TSGKL 2615
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV PL + TV E V NP W R+ + + + I
Sbjct: 2616 TVAGGA---ISKPL-----TDQTVAESQEAVFECEVA-NPDSKGEWLRDGKHLPLTNNIR 2666
Query: 881 QNFDGENIELVI--TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
DG L+I T +D +I YK S ++ K + VE V K L+
Sbjct: 2667 SESDGHKRRLIIAATKLD-DIGEYTYKVATSKTSAK--------LKVEAVKIKKTLKNLT 2717
Query: 939 ETEEGKTVI-LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
TE V +E + +W N + + I +G D V
Sbjct: 2718 VTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVY 2777
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
+ S L V ET+ + I+K +D E EV ++ +T V W IK
Sbjct: 2778 GFRLGRLGASARLHV-ETV-KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIK 2835
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
P +K+ + KL ++N S D GEY+ ++ C A++ V L I ++N +
Sbjct: 2836 PS-DKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL--HITKTMKNIE 2892
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + A+FE E++ + W K+G EI+ S ++ + GK +L I + +D+ EY+
Sbjct: 2893 VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT 2952
Query: 1178 CEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE 1237
GN + +A LTV I T L + +T + V + E + W K I+
Sbjct: 2953 FVCGNDQVSATLTVTP--IMITSMLKDINAEEKDTITF-EVTVNYEGISYKWLKNGVEIK 3009
Query: 1238 DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV--VEFPPKIVDYER 1295
T+K + + +L IR D +YT V A ST L VE +EF I D +
Sbjct: 3010 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDI-K 3068
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDA 1355
KR + + P +W+ + + ++ K + L I +DA
Sbjct: 3069 VLEKKRAMFECEVSE----PDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 3124
Query: 1356 GIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
G Y + N A + + + S + ++E + + +E + +
Sbjct: 3125 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 3184
Query: 1416 VVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+ +Q + +++ + I + S Y F A + S T Y
Sbjct: 3185 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGR-------NRSSVTLYVNAP- 3236
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENR 1532
+ P V + L+ +T + + + G PQPK++WY++ + L T K ++ +
Sbjct: 3237 ----EPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQ 3292
Query: 1533 XXXXXXXXXX-XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A ND+G TS + ++ V++ E +
Sbjct: 3293 EYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQ 3352
Query: 1592 VTAVIEGIPPP----------EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
T EG P +V WY K++ + + +T E T + I E
Sbjct: 3353 DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 3412
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLE 1697
YT ASN G S L + PE I+ E + + +E K +G E
Sbjct: 3413 TYTFVASNAVGQVSSTANLSL----EAPES--ILHERIEQEIEMEMKELFSEGESE 3462
Score = 179 bits (436), Expect = 9e-44
Identities = 174/747 (23%), Positives = 309/747 (41%), Gaps = 47/747 (6%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
SK Q V E + + EC VA P+ WL G+ + NI ESD H ++
Sbjct: 2623 SKPLTDQTVAESQEAVFECE-VANPDSKGEWLRDGKHLPLTNNIRS--ESDGHKRRLIIA 2679
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
T + E TY V + + V KIK + LK++ V + + + +
Sbjct: 2680 ATKLDDIGEYTYKVATSKTSAKLKVEAV-KIK----------KTLKNLTVTETQDAVFTV 2728
Query: 757 QVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
++ + W KN +++ G +S+ I K + DE VY + G
Sbjct: 2729 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI-KNCAIVDESVYGFRL----GR 2783
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
SA + VE I + +++T E T+ V+ + VP + W+ N I
Sbjct: 2784 LGASARLHVETVK--------IIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKNVEI 2834
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
PS+ + + +L++ N+ S D+G+Y V G+ A++ ++ +T
Sbjct: 2835 KPSDKHRLVSERKVHKLMLQNI-SPSDAGEYTAVV----GQLECKAKLFVETLHIT---K 2886
Query: 934 LQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXX 992
K+ E E KT EC+ SH V + W N EI + +I+ +G+
Sbjct: 2887 TMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE 2946
Query: 993 DVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERD 1052
D + + + S L V + L+D +EKD EV +N E W ++
Sbjct: 2947 DSAEYTFVCGNDQVSATLTVTPIM--ITSMLKDINAEEKDTITFEVTVNYEGISYKWLKN 3004
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR 1112
G IK +K + L IRN D +Y+ + + TA + V E
Sbjct: 3005 GVEIK-STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKH 3063
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+++ KV + +A FE E+++ D V+W KD E+Q ++ I++ + +L I + D
Sbjct: 3064 IKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3123
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
AG+Y+ G + TA L VE + + + + V A + E+ ++ +D WYK
Sbjct: 3124 AGKYTVVAGGNVSTAKLFVEGRDVRIR-SIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3182
Query: 1233 KSVI--EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
I + E+ + + + + I + + D EYT V +S+ L V E PP++
Sbjct: 3183 GIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPE-PPQV 3241
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
+ + ++ G PQP W +++ K D + +L + +
Sbjct: 3242 LQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEA 3301
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTI 1377
DA +Y +N+ G A ++++
Sbjct: 3302 FPEDAAVYTCEAKNDYGVATTSASLSV 3328
Score = 178 bits (434), Expect = 2e-43
Identities = 156/561 (27%), Positives = 249/561 (44%), Gaps = 26/561 (4%)
Query: 804 TLKAENSEGIAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
T+K E E S VI ++ T + P + + V E ++L +V+
Sbjct: 2324 TVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLES 2383
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
V + W ++ + + PS+ + D ++ L+I ++ E D+G+Y + G S+ G
Sbjct: 2384 VEGV-WMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKE-DAGNYSFTIP-ALGLSTSGRV 2440
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQE 978
V+ +T +K + EG +LEC+ S S KWY N ++I D + I +
Sbjct: 2441 SVYSVDVITPLKDVN----VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVK 2496
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
G D G K IV ET+ L V++ + IR L+D E + EV
Sbjct: 2497 GTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI--KIIRGLRDLTCTETQNVVFEV 2554
Query: 1039 EINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA 1098
E++ DV+W + IKP +KY E G I KL + N DEG+Y+ + +
Sbjct: 2555 ELSHSGIDVLWNFKDKEIKPS-SKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSG 2613
Query: 1099 EVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDG 1158
++TV I L +Q V + +A FE E+ D+ W +DG + +N+I+ DG
Sbjct: 2614 KLTVAG--GAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDG 2671
Query: 1159 KKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
K++L I LDD GEY+ +V SK +A L VE I TL+ + V DA TV
Sbjct: 2672 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLK---NLTVTETQDAVFTV 2728
Query: 1219 EIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
E+ + V W K V+E EK+ + +L I+ C D+ Y L ++
Sbjct: 2729 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASA 2788
Query: 1278 KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
+L VE V KI+ ++ + V V P + N +I KH S
Sbjct: 2789 RLHVETV----KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKHRLVS 2844
Query: 1338 IDSKSASLTIKKVENTDAGIY 1358
+ K L ++ + +DAG Y
Sbjct: 2845 -ERKVHKLMLQNISPSDAGEY 2864
Score = 176 bits (429), Expect = 6e-43
Identities = 155/678 (22%), Positives = 278/678 (41%), Gaps = 27/678 (3%)
Query: 712 AVNREGEASLPIVLKIK---TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
A+ EG+ ++P K + E P++ E ++S V QG +VVG P P W
Sbjct: 2052 ALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEW 2111
Query: 769 CKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
KN ++ + D +++ +D +KA N G + A + V+
Sbjct: 2112 YKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA- 2170
Query: 826 TEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
+ F Q++ KEK T+ T P + WY++ + + + D
Sbjct: 2171 ----KQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDR 2226
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+ L I +D+ D+ DY CV + A++ ++ V FVK LQ E E +
Sbjct: 2227 KVHFLSILTIDTS-DAEDYSCVLVEDENVKT-TAKLIVEGAVVEFVKELQ-DIEVPESYS 2283
Query: 946 VILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ 1004
LEC S + KWYHN E+ I D G ++ +
Sbjct: 2284 GELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK 2343
Query: 1005 ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY- 1063
+T+ L +K ++ L D +V E D+ LEV+++ E+ + VW +DG+ ++P +
Sbjct: 2344 KTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHI 2403
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
+K+ H+ L I + + D G YS + + V ++IT L++ V +G K
Sbjct: 2404 VIDKQSHM--LLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTK 2461
Query: 1124 ATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
A E +++ D V+W+ + +I+ + +Q + G KQ+L I D G Y VG
Sbjct: 2462 AVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGR 2521
Query: 1183 SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKF 1242
+ L+VE+ I LR + + VE+ +DV W K I+ + K+
Sbjct: 2522 VETNCNLSVEKIKIIRGLR---DLTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKY 2578
Query: 1243 TLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
+ + K L + +DD+ +YT + ++ KL V + D +
Sbjct: 2579 KIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAGGAISKPLTD----QTVAES 2634
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
+ + A P EW+ + K + + + D L I + D G Y ++
Sbjct: 2635 QEAVFECEV-ANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKV 2693
Query: 1363 ENNCGHADVEMNVTILDK 1380
+ A +++ + K
Sbjct: 2694 ATSKTSAKLKVEAVKIKK 2711
Score = 166 bits (404), Expect = 7e-40
Identities = 246/1096 (22%), Positives = 440/1096 (40%), Gaps = 86/1096 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P ++ ++Q V +GSD R+V P+P+ W G +I + I D C
Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPED--NVCE 2135
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
L I +V + V A+N GE S L ++ K+ + L+ ++ ++ +++
Sbjct: 2136 -LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA--KQLITFTQELQDVVAKEKDTMA 2192
Query: 754 LSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
P + W K+ V SD H ++IL D Y+
Sbjct: 2193 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSIL-TIDTSDAEDYSCVLVED 2251
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
E + +T+A + VE E F+ Q+I V E + +L V+ + WY N+
Sbjct: 2252 ENV-KTTAKLIVEGAVVE------FVKELQDIEVPESYSGELECIVSPENIEG-KWYHND 2303
Query: 871 -EIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
E+ S + TIT +N L + +V E D G+Y V GK + ++ + +
Sbjct: 2304 VELKSNGKYTITSRRGRQN--LTVKDVTKE-DQGEYSFVID---GKKT-TCKLKMKPRPI 2356
Query: 929 TFVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
++ L + EG V LE + S +V W + +E+ D I+ + +
Sbjct: 2357 AILQGL-SDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIE 2415
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
D G + ST V + I L+D V E A+LE +++ +
Sbjct: 2416 DMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTS 2475
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELP 1106
V W + E IKP ++ +G ++L I T DEG Y I+ ++V ++
Sbjct: 2476 VKWYLNDEQIKP-DDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI- 2533
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVRW-FKDGSEIQFSNHIQLTIDGKKQKLKI 1165
+II L++ + FE+EL+ V W FKD EI+ S+ ++ GK KL +
Sbjct: 2534 -KIIRGLRDLTCTETQNVVFEVELSHSGIDVLWNFKD-KEIKPSSKYKIEAHGKIYKLTV 2591
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
+ DD G+Y+ G + + LTV +I+ L V + +A E+ +
Sbjct: 2592 LNMMKDDEGKYTFYAGENITSGKLTVAGGAISKPLTDQ---TVAESQEAVFECEVANPDS 2648
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
W + + T SD KR LII DD EYT + +K++ KLKVE V
Sbjct: 2649 KGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAV- 2707
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
KI + + D V+ +WI N +++ + S+ SL
Sbjct: 2708 ---KIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSL 2764
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEM-NVTILDKPSPPGKPNILEIDSSSINICWDEP 1404
IK D +Y RL A + + V I+ KP ++ ++++++
Sbjct: 2765 RIKNCAIVDESVYGFRLGRLGASARLHVETVKIIKKPK-----DVTALENATVAFEVSVS 2819
Query: 1405 ENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDA 1464
+T + VE + D +S + + K +QN+ + + + A V +++
Sbjct: 2820 HDTVPVKWFHKNVEIKPSDKHRLVSERKVHKLM--LQNISPSDAGEYTA-VVGQLECK-- 2874
Query: 1465 SETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
K+ ET + K +KNI + C P + W ++G +++
Sbjct: 2875 ------AKLFVETL----HITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEM 2923
Query: 1525 A---KATYENR-XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDI 1580
+ K + + Y + ND +V + V +IT +DI
Sbjct: 2924 SEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGND--QVSATLTV---TPIMITSMLKDI 2978
Query: 1581 KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHS 1640
+ K + VT EGI W KNG ++++ + + TK+ T + I+ + +
Sbjct: 2979 NAEEKDTITFEVTVNYEGI---SYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDA 3035
Query: 1641 SKYTIEASNTAGTSSVEVTLKVYD--------KPSKPEGPVIMREISRESVTIEWKPPLD 1692
+ YT A T+++ V + + K + + + E+S +T++W D
Sbjct: 3036 ADYTFVAGKATSTATLYVEARHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMK--D 3093
Query: 1693 DGGLELT-KYAIEKHE 1707
D L++T + I+K +
Sbjct: 3094 DQELQITDRIKIQKEK 3109
Score = 133 bits (322), Expect = 6e-30
Identities = 159/677 (23%), Positives = 272/677 (40%), Gaps = 67/677 (9%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
KKPK E + + E + P + W K EI P + + E +H L +
Sbjct: 2799 KKPKDVTALENATVAFEVSVSHDTVP-VKWFHKNVEIKPSDKHRLVSERKVHK----LML 2853
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
N+ G YT V E +A L + E + + +K++ V + ++ +
Sbjct: 2854 QNISPSDAGEYTAVVGQLECKAKLFV---------ETLHITKTMKNIEVPETKTASFECE 2904
Query: 758 VVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V P++ W KN ++ G H + I+ +D YT N +
Sbjct: 2905 VSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTS-TEDSAEYTFVCGNDQ--- 2959
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
SA +TV P + + ++I +EK TI V + S W +N I
Sbjct: 2960 -VSATLTVT--------PIMITSMLKDINAEEKDTITFEVTVNYEGI-SYKWLKNGVEIK 3009
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL 934
++ L I NV D+ DY VA GK++ A + ++ + F KH+
Sbjct: 3010 STDKCQMRTKKLTHSLNIRNVHFG-DAADYTFVA----GKATSTATLYVEARHIEFRKHI 3064
Query: 935 QKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD 993
K + E K + EC+ S ++ +W + +E+ D +I +E D
Sbjct: 3065 -KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3123
Query: 994 VGVIKCIVKDQETSTMLVVKETIPEFIRKLQ-DFEVKEKDVAILEVEINSETADVVWERD 1052
G +V ST + E IR ++ + +V EK A++E E+N + D W +D
Sbjct: 3124 AGKYT-VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3182
Query: 1053 GEIIK---PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL-RDESCTAEVTVVELPPE 1108
G I +++KY E+R H +++I T D GEY+ + R+ S PP+
Sbjct: 3183 GIEINFQVQERHKYVVERRIH--RMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQ 3240
Query: 1109 IITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
++ LQ V G A F ++ + + W+K+ + + DG++ L + +
Sbjct: 3241 VLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIE 3300
Query: 1168 CDLDDAGEYSCEVGN----SKCTAILTVEEPSI-NFTLRLPEF---ILVPANTD------ 1213
+DA Y+CE N + +A L+VE P + + +P + I+ P
Sbjct: 3301 AFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQ 3360
Query: 1214 -AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
A + L V+WY K I+ + F + L I + +D+ YT V +
Sbjct: 3361 PARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASN 3420
Query: 1273 A----KSTTKLKVEVVE 1285
A ST L +E E
Sbjct: 3421 AVGQVSSTANLSLEAPE 3437
Score = 107 bits (258), Expect = 3e-22
Identities = 105/448 (23%), Positives = 177/448 (39%), Gaps = 41/448 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P V L+ +G +V EC + GYP P +TW+R+ I+ S DFQ+ + +A L+
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF-QSGIARLM 1001
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXXXXXXXXAD 627
IRE F ED+G FTC A N AG S++ L V+ + +T D
Sbjct: 1002 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRD 1061
Query: 628 IL--------------EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEE 673
++ E P F KP Q + EG ++ C++ P+P + W G
Sbjct: 1062 VVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVP 1121
Query: 674 IVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE 733
+ V+ V+ +T G YT+V N+ GE S L E +
Sbjct: 1122 LTTGYRYKVSYNKQTGECKLVISMTFAD--DAGEYTIVVRNKHGETSASASL---LEEAD 1176
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
+++ + M+ + + + VG P + + K + T++
Sbjct: 1177 YELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVV 1236
Query: 794 PKKVKDEGVYTLKAENS--EGIAETSAVITVEEPTEENAEPPLFIN-------------R 838
V+D+ + E + I T+EE EE+ E + ++ R
Sbjct: 1237 RTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDLR 1296
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF--DGENIELVITNVD 896
+ + E + +++ P+P I WY++ + I E +F DG L I V
Sbjct: 1297 IKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVL 1355
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTID 924
E D G Y ASN G + ++ ++
Sbjct: 1356 PE-DEGIYTAFASNIKGNAICSGKLYVE 1382
Score = 93.9 bits (223), Expect = 6e-18
Identities = 69/268 (25%), Positives = 122/268 (45%), Gaps = 19/268 (7%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
I+ ++ G YT VA +L + EPPQV++ L+ + V+ G+ A
Sbjct: 3207 ISETRQSDAGEYTFVAGRNRSSVTLYV------NAPEPPQVLQELQPVTVQSGKPARFCA 3260
Query: 757 QVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
+ G P+P I+W K + + DG +++ +++ +D VYT +A+N G+
Sbjct: 3261 VISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFP-EDAAVYTCEAKNDYGV 3319
Query: 814 AETSAVITVEEPT------EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
A TSA ++VE P E PP I Q+ E + RV+ + ++WY
Sbjct: 3320 ATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWY 3378
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
++ I PS + +L I E D G Y VASN+ G+ S A ++++ +
Sbjct: 3379 SKDKKIKPSRFFRMTQFEDTYQLEIAEAYPE-DEGTYTFVASNAVGQVSSTANLSLEAPE 3437
Query: 928 VTFVKHLQKSYETEEGKTVILECQTSHT 955
+ +++ E E K + E ++ H+
Sbjct: 3438 SILHERIEQEIEMEM-KELFSEGESEHS 3464
Score = 91.5 bits (217), Expect = 3e-17
Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA--LP----TKSDGDT 786
+ P +PL+S++V +G + A + G P P ++W ++ + + LP + SDG
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
+TI K + G Y+LKA N G A ++A + V+ T PP F+ R Q +TV++
Sbjct: 64 -KLTIPAVTKA-NSGRYSLKATNGSGQATSTAELLVKAETA----PPNFVQRLQSMTVRQ 117
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
++L RVT P P + +YR+ I S + +G+ L+I E DSG Y
Sbjct: 118 GSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPE-DSGTYSV 176
Query: 907 VASNSAGKSSHGARVTIDVEK 927
A+NS G+++ A + + E+
Sbjct: 177 NATNSVGRATSTAELLVQGEE 197
Score = 91.5 bits (217), Expect = 3e-17
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTH 787
+P V++P+ S +G++ +VVG P P W + + + + K DG T
Sbjct: 1456 KPVFVLKPV-SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG-TQ 1513
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
S+ I+ P D G +T+ A+N G + S ++TVE E+ P+F+ + + + +KE
Sbjct: 1514 SLIIV-PATPSDSGEWTVVAQNRAGRSSISVILTVE--AVEHQVKPMFVEKLKNVNIKEG 1570
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEI--DSGDYK 905
+++ R T NP P I W +N++II P + +G E + +DS + DS Y
Sbjct: 1571 SQLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL-KIDSTVSQDSAWYT 1629
Query: 906 CVASNSAGKSSHGARVTIDVE 926
A N AG+ + +V ++VE
Sbjct: 1630 ATAINKAGRDTTRCKVNVEVE 1650
Score = 88.2 bits (209), Expect = 3e-16
Identities = 61/202 (30%), Positives = 99/202 (49%), Gaps = 9/202 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYC 692
PTF++ ++ V EGS E + P P+++W G+ I V I SD
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR--- 62
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L I V K G Y++ A N G+A+ L +K E PP ++ L+SM VRQG V
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-ETAPPNFVQRLQSMTVRQGSQV 121
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L +V G P P + + ++ +++ +GD +S+ I + +D G Y++ A N
Sbjct: 122 RLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYP-EDSGTYSVNATN 180
Query: 810 SEGIAETSAVITVEEPTEENAE 831
S G A ++A + V+ E A+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAK 202
Score = 86.6 bits (205), Expect = 9e-16
Identities = 156/772 (20%), Positives = 296/772 (38%), Gaps = 84/772 (10%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
+K K V E EC + P + WL G EI E + ++ +H L
Sbjct: 2885 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ----LI 2939
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
I N YT V N + A+L + P + LK + + +++
Sbjct: 2940 IMNTSTEDSAEYTFVCGNDQVSATLTVT---------PIMITSMLKDINAEEKDTITFEV 2990
Query: 757 QVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
V + W KN +K+ ++ THS+ I + D YT A G
Sbjct: 2991 -TVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNI-RNVHFGDAADYTFVA----GK 3044
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A ++A + VE E F ++I V EK V+ P ++ W ++++ +
Sbjct: 3045 ATSTATLYVEARHIE------FRKHIKDIKVLEKKRAMFECEVSE-PDITVQWMKDDQEL 3097
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ I + L+I + D+G Y VA + A++ ++ V ++
Sbjct: 3098 QITDRIKIQKEKYVHRLLIPSTRMS-DAGKYTVVAGGNVST----AKLFVEGRDVR-IRS 3151
Query: 934 LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGM--DHREIIQEGRXXXXXXXXXX 990
++K + E + ++E + + V WY + EI+ + + + E R
Sbjct: 3152 IKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETR 3211
Query: 991 XXDVGVIKCIV-KDQETSTMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVV 1048
D G + +++ + T+ V P+ +++LQ V+ K V +
Sbjct: 3212 QSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKIS 3271
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE------SCTAEVTV 1102
W ++ +++ K F G L + D Y+C +++ S + V V
Sbjct: 3272 WYKEEQLLSTGF-KCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEV 3330
Query: 1103 VEL----------PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
E+ PP IIT LQ+ ++G A F+ ++ D V W+ +I+ S
Sbjct: 3331 PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFF 3390
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANT 1212
++T +L+I + +D G Y+ N A+ V + N +L PE IL +
Sbjct: 3391 RMTQFEDTYQLEIAEAYPEDEGTYTFVASN----AVGQVSS-TANLSLEAPESIL---HE 3442
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
+E+ + L + S + + F+ D+ +++ ++ Y +
Sbjct: 3443 RIEQEIEMEMKELFSEGESEHSERDTRDAFSDSEDIDHKSMAAKR--------YASRISS 3494
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII---- 1328
S + F P + G V A P P W N++ I
Sbjct: 3495 TSSWPEY------FKPSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGL 3548
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
++ + + S+SL IK+V++ D+G Y+L N+ G A+ ++ ++ K
Sbjct: 3549 RRIIKAESDLHHHSSSLEIKRVQDRDSGSYRLLAINSEGSAESTASLLVIQK 3600
Score = 86.2 bits (204), Expect = 1e-15
Identities = 61/211 (28%), Positives = 94/211 (44%), Gaps = 9/211 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F KP + EG + ++V P P+ W G++IV D V I+ D
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE-PPQVIEPLKSMIVRQGESV 752
++ T G +TVVA NR G +S+ ++L ++ E + P +E LK++ +++G +
Sbjct: 1517 IVPAT---PSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSQL 1573
Query: 753 ILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKV-KDEGVYTLKAE 808
+ + GNP P I W KN+ P K + +G + V +D YT A
Sbjct: 1574 EMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAI 1633
Query: 809 NSEGIAETSAVITVE-EPTEENAEPPLFINR 838
N G T + VE E E E L I R
Sbjct: 1634 NKAGRDTTRCKVNVEVEFAEPEPERKLIIPR 1664
Score = 83.0 bits (196), Expect = 1e-14
Identities = 75/292 (25%), Positives = 118/292 (40%), Gaps = 21/292 (7%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
EP ++N PP FI + V E T+ + V PVP + WYRN ++ P E I
Sbjct: 5175 EP-KDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMER 5233
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI--DVEKVTFV------KHLQ 935
G L I+N+ + G+Y C A N G++ A V I E+V + +H+
Sbjct: 5234 VGNVCSLEISNIQKG-EGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVM 5292
Query: 936 K-------SYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ S T + ++LE + S K + + +I + +
Sbjct: 5293 EFDLEHTTSSRTPSPQEIVLEVELSEK-DVKEFEKQVKIVTVPEFTPDHKSMIVSLDVLP 5351
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVE-INSETADV 1047
D + +D+E L V E P FI + DF++ E A+ + I T +V
Sbjct: 5352 FNFVDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEV 5411
Query: 1048 VWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
W ++ I+P KY + L IRN + D Y C R +C E
Sbjct: 5412 KWYKEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRC--RAVNCVGE 5461
Score = 81.0 bits (191), Expect = 4e-14
Identities = 65/245 (26%), Positives = 104/245 (42%), Gaps = 31/245 (12%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
E+ P+FV K +G T +F+ +V G P P+ WF I ++ +D
Sbjct: 1452 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1511
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I P D+G +T VA+N AG +S + L VEA
Sbjct: 1512 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA---------------------- 1549
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
+ + P F +K K + EGS + ++ R P PDI WL + IVP + + I
Sbjct: 1550 ---VEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRI 1606
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + LKI + YT A+N+ G + + ++ EP EP + +
Sbjct: 1607 EGTKGE--AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP----EPERKL 1660
Query: 745 IVRQG 749
I+ +G
Sbjct: 1661 IIPRG 1665
Score = 77.8 bits (183), Expect = 4e-13
Identities = 65/247 (26%), Positives = 105/247 (42%), Gaps = 29/247 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +++L+P G +F + G P+P+I+W+++ ++ + +D TL+
Sbjct: 3239 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEY-TLL 3297
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP-LSDHGSEMTVXXXXXXXXXXXXADI 628
+ E FPEDA +TC AKN G A+++ L VE P + EM V
Sbjct: 3298 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPV--------------- 3342
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
PP + EG +CR V+ + ++W K ++I P + D
Sbjct: 3343 ---YPPAIITPLQDTVTSEGQPARFQCR-VSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT 3398
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE----KEPPQVIEPLKSM 744
+ L+I EGTYT VA N G+ S L ++ E + Q IE
Sbjct: 3399 YQ----LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKE 3454
Query: 745 IVRQGES 751
+ +GES
Sbjct: 3455 LFSEGES 3461
Score = 76.2 bits (179), Expect = 1e-12
Identities = 64/231 (27%), Positives = 104/231 (45%), Gaps = 35/231 (15%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ--DFQMYYDDDN 564
+ AP F + L+ +GST FE + G+P P+++WFR +I S Q+ + D
Sbjct: 3 TQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
A L I V ++G ++ A N +G A+ST +E+ V
Sbjct: 63 -AKLTIPAVTKANSGRYSLKATNGSGQATST-------------AELLVKA--------- 99
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
E PP F ++ ++ V +GS + L+ R+ IP P + + G EI + ++
Sbjct: 100 -----ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQ 154
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP 735
E D++ L I GTY+V A N G A+ L ++ GE+E P
Sbjct: 155 EGDLYS----LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ-GEEEVP 200
Score = 73.7 bits (173), Expect = 6e-12
Identities = 41/112 (36%), Positives = 60/112 (53%), Gaps = 2/112 (1%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
++P P E P + L+ T +G +F+C+V G +++W+ + IKPS
Sbjct: 3329 EVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPS 3387
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ F+M +D L I E +PED GT+T VA NA G SST L +EAP S
Sbjct: 3388 RFFRMTQFEDTYQ-LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPES 3438
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 1/96 (1%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
++ P FV++L+ GS V+ + +V G P P + ++R A I+ S DFQ+ + D +
Sbjct: 100 ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD-L 158
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+L+I E +PED+GT++ A N+ G A+ST EL+V+
Sbjct: 159 YSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 72.1 bits (169), Expect = 2e-11
Identities = 78/323 (24%), Positives = 139/323 (43%), Gaps = 27/323 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F ++ ++Q V EG C P+P + W + + +P N + I S + Y
Sbjct: 3943 PPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTW-YNNDMPIP-RNQNFIIHS-LENY- 3998
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGE 750
S+L +++V EG+ T V N+ G +LK+K +K + + + + E
Sbjct: 3999 SILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDVKAHKVPVFHDYLDEEEE 4058
Query: 751 SVILSAQVVG-NPRPTITWCKNNKPVKALP-TKSDGDTH--------SITILKPKKVKD- 799
++ Q G +P + N +K P GDT +T P +D
Sbjct: 4059 LALVFDQAKGAHPSMSQEGQTNLHLLKTNPPVPPSGDTELLSFPVEIQVTAATPIPEQDK 4118
Query: 800 EGVYTLKAENSEGIAETSAVITVEEP------TEENAEPPLFINRF-QEITVKEKGTIKL 852
E + E E A +T ++ EPP + + +E +I L
Sbjct: 4119 ESKEVFQTEELEPKAMPQDQVTQSPKHRFVFLSDITNEPPKMLQEMPKHARCREGDSIIL 4178
Query: 853 VARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSA 912
++ P P +TW++N ++ ++ + +L I +V+S+ DSG YKCVA N++
Sbjct: 4179 ECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQ-DSGKYKCVAENNS 4237
Query: 913 GKSSHGARVTIDVEKVTFVKHLQ 935
G + +T VE VT+ ++ Q
Sbjct: 4238 GAVESVSDLT--VEPVTYRENSQ 4258
Score = 70.1 bits (164), Expect = 8e-11
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 1/105 (0%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E P+F++K +YV EG ++ CRL+A P P++ W I + ESD+H
Sbjct: 3500 EYFKPSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLH 3559
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKE 733
+ S L+I V+ G+Y ++A+N EG A S +L I+ G+ E
Sbjct: 3560 HHSSSLEIKRVQDRDSGSYRLLAINSEGSAESTASLLVIQKGQDE 3604
Score = 66.1 bits (154), Expect = 1e-09
Identities = 37/104 (35%), Positives = 56/104 (53%), Gaps = 2/104 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE +++ F +++ +G V F C++ GYP P+I W++ IK + +QM +
Sbjct: 1284 SESEAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQ 1343
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE--APL 604
D A+L I V PED G +T A N G A + +L VE APL
Sbjct: 1344 DGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPL 1387
Score = 65.7 bits (153), Expect = 2e-09
Identities = 54/185 (29%), Positives = 83/185 (44%), Gaps = 9/185 (4%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNK-YDFEKRGHIRKL 1074
P F + LQ V E A E I+ +V W RDG++I KL
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1075 YIRNTSVHDEGEYSCILRDES----CTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEI 1128
I + + G YS + S TAE+ V PP + RLQ+ V +G++ ++
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 1129 ELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
+T +V++++DG+EIQ S Q++ +G L I + +D+G YS NS A
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 1188 ILTVE 1192
T E
Sbjct: 186 TSTAE 190
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/87 (35%), Positives = 54/87 (62%), Gaps = 5/87 (5%)
Query: 518 PKHTP--DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA-TLVIREVF 574
PKH +G ++ EC + G P+P +TWF+ ++K +Q FQ +++ N + L I++V
Sbjct: 4165 PKHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQ--FEEVNCSHQLYIKDVN 4222
Query: 575 PEDAGTFTCVAKNAAGFASSTTELIVE 601
+D+G + CVA+N +G S ++L VE
Sbjct: 4223 SQDSGKYKCVAENNSGAVESVSDLTVE 4249
Score = 64.1 bits (149), Expect = 5e-09
Identities = 63/276 (22%), Positives = 119/276 (43%), Gaps = 32/276 (11%)
Query: 337 EKTELEQPLFSYEDIVESKKDENEIIQEKQTL--EELPKEDVPEQYTITPRKSSAQKIDE 394
+ E E+ S++ IV+ + + EI ++ L E LPK+ + + + + +++E
Sbjct: 3782 QNIESEELPTSFQTIVDEEIFQTEIRMSQEALVKESLPKDHLYGEILVNENTQARGQLEE 3841
Query: 395 IVDEVTIKKRLNPF-------EIFYTPVEVRCGDTVFAVYSYVAETDEAINLVEGERLYI 447
I+ TI + E++ TP V T A S+ +N+ E E +
Sbjct: 3842 IMANTTIGESSTYITNVCEKEEVYETPENVSQAITPHASESF----GTLVNVEESEEIAS 3897
Query: 448 LDTSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEE-Q 506
D +Q + A +DE K +K + + FE + Q
Sbjct: 3898 ERIKKDDLRELQ---------LSASTRIDEF--------KTEQKEENMRFFENSFRKRPQ 3940
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
P F++++ + +G + F C +GYP+P +TW+ I +Q+F + + +N +
Sbjct: 3941 RCPPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNF-IIHSLENYS 3999
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
L + V ++ G+ TCV N G +T+ L V+A
Sbjct: 4000 ILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKA 4035
Score = 63.7 bits (148), Expect = 7e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 2/110 (1%)
Query: 495 LPVFEKPTSE-EQSM-APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKP 552
+P F+ E SM AP E+++ + GS F +V G P P+ W++ I+
Sbjct: 2061 IPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIER 2120
Query: 553 SQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
S Y+ +DNV LVIR+V ED+ + A N AG SS L+V+A
Sbjct: 2121 SDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2170
Score = 58.8 bits (136), Expect = 2e-07
Identities = 107/460 (23%), Positives = 186/460 (40%), Gaps = 73/460 (15%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
++ M P F+E L + + +T+ F +VEG P P + W+R ++++P + +M
Sbjct: 5177 KDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKM-ERVG 5235
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
NV +L I + + G + C A N G A S + + E V
Sbjct: 5236 NVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQ-----EERVVALPPPVTHQH 5290
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
LE T S+ P Q +I+LE V + E D+ K +IV +
Sbjct: 5291 VMEFDLE--HTTSSRTPSPQ------EIVLE---VELSEKDVKEFEKQVKIVTVPEFTPD 5339
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE-ASLPIVLKIKTGEKEPPQVIEPLK 742
+S M + VL V + +REGE L I L++ + PP+ I P+
Sbjct: 5340 HKS-MIVSLDVLPFNFVDPNMD--------SREGEDKELKIDLEV---FEMPPRFIMPIC 5387
Query: 743 SMIVRQGESVILSAQVVGNPRPTITW-----CKNNKPVKALPTKSDGDTHSITILKPKKV 797
+ + + V+G P P + W C +K + ++ G +H++ I + +
Sbjct: 5388 DFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEKG-SHTLKI-RNVCL 5445
Query: 798 KDEGVYTLKAENSEGIA-----------ETSAVI------TVEEPTEENAEPPLFINRFQ 840
D Y +A N G A E AVI T+ EE + + F
Sbjct: 5446 SDSATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVLKSNYTDSFF 5505
Query: 841 EITVKEKGTIKLVARVT--RNPVPSITWYRNNEIISPSETITQNFDGENIE--------- 889
E V E G + + ++ P+ + +++ SP T+ DG+ ++
Sbjct: 5506 EFQVVE-GPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGRRFTVEES 5564
Query: 890 ------LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
L IT++ + D G+Y+CVA+N +G + A +T+
Sbjct: 5565 GTGFHNLFITSL-VKSDEGEYRCVATNKSGMAESFAALTL 5603
Score = 57.6 bits (133), Expect = 5e-07
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 7/197 (3%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------ATYENRX 1533
Q+PT +PL+++ G P P+V+W+RDG+ + T+ + + R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDEWLV 1592
Y A N G+ ++ + ++ + + ++ + G + +
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ GIP P V +Y++G ++++ ++ I+ + + I E S Y++ A+N+ G
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 1653 TSSVEVTLKVYDKPSKP 1669
++ L V + P
Sbjct: 184 RATSTAELLVQGEEEVP 200
Score = 57.6 bits (133), Expect = 5e-07
Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E+ + AP F+ K + +G +V F CQV G P+P + W + + +++
Sbjct: 1071 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKV 1130
Query: 559 YYD-DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
Y+ LVI F +DAG +T V +N G S++ L+ EA
Sbjct: 1131 SYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEA 1175
Score = 56.4 bits (130), Expect = 1e-06
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 5/136 (3%)
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A+ + V P E PP ++ + +TV E ++ L ++ P P++TWYR + I
Sbjct: 924 AKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQI 983
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
S F L+I +E DSG + C A N AG S + + V + F K
Sbjct: 984 ESSIDFQITFQSGIARLMIREAFAE-DSGRFTCSAVNEAGTVSTSCYLAVQVSE-EFEKE 1041
Query: 934 ---LQKSYETEEGKTV 946
+ + + TEE + V
Sbjct: 1042 TTAVTEKFTTEEKRFV 1057
Score = 56.4 bits (130), Expect = 1e-06
Identities = 66/340 (19%), Positives = 121/340 (35%), Gaps = 29/340 (8%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
E PP ++ + ++ + + +V+ + P P +W N +++ + K S
Sbjct: 5180 EMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCS 5239
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK-------PSPPGKPNILEIDSSSI 1397
L I ++ + G Y N G A NV I+ + P P +++E D
Sbjct: 5240 LEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEHT 5299
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
T + I VE E D E+ VK +T + + + S +
Sbjct: 5300 T-----SSRTPSPQEIVLEVELSEKDVKEFEKQVKIVTVPEFTPDHKSMIVSLDVLPFNF 5354
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY 1516
+ ++ + K+ E P P+ + N D C G+P P+V WY
Sbjct: 5355 VDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWY 5414
Query: 1517 RDGKKLKTAKATY-----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEV---------ETS 1562
++ ++ Y + Y+C A N GE ++
Sbjct: 5415 KEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRCRAVNCVGEAICRGFLTMGDSE 5474
Query: 1563 CVVGIQQKPVITISN--EDIKQKHKVGDEWLVTAVIEGIP 1600
I +K +T+S+ E++ K D + V+EG P
Sbjct: 5475 IFAVIAKKSKVTLSSLMEELVLKSNYTDSFFEFQVVEGPP 5514
Score = 55.6 bits (128), Expect = 2e-06
Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENR 1532
E + PT+ LKN+T E + L C G P P VTWYR+ +++++ + T+++
Sbjct: 937 EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG 996
Query: 1533 -XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+ C A N+ G V TSC + +Q
Sbjct: 997 IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033
Score = 53.6 bits (123), Expect = 7e-06
Identities = 27/100 (27%), Positives = 48/100 (48%), Gaps = 2/100 (2%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
T +++ P V P +G T +F C+V GYP+P++ W+ +I+ S+ F++ Y
Sbjct: 1833 TDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY- 1891
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
D + L I + D G A+N G +L ++
Sbjct: 1892 -DGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1930
Score = 51.6 bits (118), Expect = 3e-05
Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 5/116 (4%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT--I 791
PP ++ LK++ V +GESV L + G P PT+TW + + +++ I +
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 1001
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
++ +D G +T A N G TS + V+ E E +F T +EK
Sbjct: 1002 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKF---TTEEK 1054
Score = 50.8 bits (116), Expect = 5e-05
Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 3/94 (3%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD---NVA 566
P F +KL K+ +G V F C++ P P++TWF I + + D + +
Sbjct: 3504 PSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLHHHSS 3563
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+L I+ V D+G++ +A N+ G A ST L+V
Sbjct: 3564 SLEIKRVQDRDSGSYRLLAINSEGSAESTASLLV 3597
Score = 50.4 bits (115), Expect = 7e-05
Identities = 73/330 (22%), Positives = 129/330 (39%), Gaps = 42/330 (12%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E + F + K + EG + C++ P P IAW G+ I E + D
Sbjct: 1287 EAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGR 1346
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+ L+I V EG YT A N +G A I +G+ +EP +
Sbjct: 1347 ---ASLRIPVVLPEDEGIYTAFASNIKGNA-------ICSGKL----YVEPAAPL---GA 1389
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ I + + V R + P++ P + + P ++ + +
Sbjct: 1390 PTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR----------MSPARMSPARMSPARMSP 1439
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ ET +E E P+F+ + E T + +V P+P W+ +
Sbjct: 1440 GRRLEET------DESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHD 1493
Query: 870 NEIISPSET--ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID-VE 926
+ I T + DG +++ S DSG++ VA N AG+SS +T++ VE
Sbjct: 1494 GQQIVNDYTHKVVIKEDGTQSLIIVPATPS--DSGEWTVVAQNRAGRSSISVILTVEAVE 1551
Query: 927 ---KVTFVKHLQKSYETEEGKTVILECQTS 953
K FV+ L K+ +EG + ++ + +
Sbjct: 1552 HQVKPMFVEKL-KNVNIKEGSQLEMKVRAT 1580
Score = 49.6 bits (113), Expect = 1e-04
Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 3/118 (2%)
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+ E E +A A+ V +E +P + + + + V E T + RVT P P +
Sbjct: 1815 RIEELERMAHEGALTGVTTDQKEKQKPDIVLYP-EPVRVLEGETARFRCRVTGYPQPKVN 1873
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
WY N ++I S+ +DG + L I + S D+G+ K A N G H ++ I
Sbjct: 1874 WYLNGQLIRKSKRFRVRYDGIHY-LDIVDCKS-YDTGEVKVTAENPEGVIEHKVKLEI 1929
Score = 49.2 bits (112), Expect = 2e-04
Identities = 29/90 (32%), Positives = 50/90 (55%), Gaps = 3/90 (3%)
Query: 1029 KEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEY 1087
+E D ILE I+ E VV W ++G ++K + K+ FE+ +LYI++ + D G+Y
Sbjct: 4171 REGDSIILECLISGEPQPVVTWFQNGVLLK-QNQKFQFEEVNCSHQLYIKDVNSQDSGKY 4229
Query: 1088 SCILRDESCTAEVTVVELPPEIITRLQNQK 1117
C+ + S E +V +L E +T +N +
Sbjct: 4230 KCVAENNSGAVE-SVSDLTVEPVTYRENSQ 4258
Score = 48.8 bits (111), Expect = 2e-04
Identities = 42/198 (21%), Positives = 80/198 (40%), Gaps = 14/198 (7%)
Query: 1472 KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY-- 1529
K+ +++P + + +++ T D G P P+ WY++G K++ + Y
Sbjct: 2068 KIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWY 2127
Query: 1530 ---ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE--DIKQKH 1584
+N A N GE + + +Q K +IT + E D+ K
Sbjct: 2128 WPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKE 2187
Query: 1585 KVGDEWLVTAVIEGIPP-PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY 1643
K + + T E P +V WYK+G ++ +Y + + K + I + S + Y
Sbjct: 2188 K---DTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDY 2244
Query: 1644 T---IEASNTAGTSSVEV 1658
+ +E N T+ + V
Sbjct: 2245 SCVLVEDENVKTTAKLIV 2262
Score = 48.0 bits (109), Expect = 4e-04
Identities = 76/333 (22%), Positives = 128/333 (38%), Gaps = 34/333 (10%)
Query: 1090 ILRDESCTAEVTVVELP--PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEI 1146
++ D S T E P P IT+ QK+ +G F ++ V W K G +
Sbjct: 1063 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1122
Query: 1147 QFSNHIQLTIDGK--KQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTL 1200
+++ + + + KL I DDAGEY+ V G + +A L +EE +
Sbjct: 1123 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL-LEEADYELLM 1181
Query: 1201 RLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
+ + +L A++ ET Y + + E+ + + K T+++R E
Sbjct: 1182 KSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE 1241
Query: 1261 DDQ-------------CEYTCV------LLDAKSTTKLKVEVVEFPPKIVDYE---REYR 1298
D + EY + LL+ K+ V++ E ++ + YR
Sbjct: 1242 DQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDLRIKNYR 1301
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC-KHTKPSIDSKSASLTIKKVENTDAGI 1357
I G VT +P P W + K IK ++ + ASL I V D GI
Sbjct: 1302 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1361
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
Y N G+A + ++ +P G P +
Sbjct: 1362 YTAFASNIKGNA-ICSGKLYVEPAAPLGAPTYI 1393
Score = 48.0 bits (109), Expect = 4e-04
Identities = 54/243 (22%), Positives = 85/243 (34%), Gaps = 21/243 (8%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVE--GYPRPQITWFRQTAIIKPSQDFQMYYD 561
+E+ P F +KL FEC++ G P + W ++ + +M +
Sbjct: 1697 KEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMI-N 1755
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV--EAPLSDHGS---------- 609
+ +L + D+G TC A N G ++ LIV E L +
Sbjct: 1756 EFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQR 1815
Query: 610 -EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWL 668
E D E P P+ V EG CR+ P+P + W
Sbjct: 1816 IEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWY 1875
Query: 669 FKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
G+ I + V + +H L I + K + G V A N EG + L+I+
Sbjct: 1876 LNGQLIRKSKRFRVRYDG-IH----YLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1930
Query: 729 TGE 731
E
Sbjct: 1931 QRE 1933
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/68 (35%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P PE W+ +G ++ ND + + KE T + I S S ++T+ A N AG S
Sbjct: 1480 VVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRS 1539
Query: 1655 SVEVTLKV 1662
S+ V L V
Sbjct: 1540 SISVILTV 1547
Score = 47.2 bits (107), Expect = 6e-04
Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 9/158 (5%)
Query: 1229 WYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK----LKVEV 1283
W+ + ++ D +I + ++LII T D E+T V + + L VE
Sbjct: 1490 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA 1549
Query: 1284 VEFP--PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
VE P V+ + IK GS + + V P P+ W+ NS II K+ K I+
Sbjct: 1550 VEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGT 1609
Query: 1342 --SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
A+L I + D+ Y N G V +
Sbjct: 1610 KGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1647
Score = 46.8 bits (106), Expect = 9e-04
Identities = 67/289 (23%), Positives = 117/289 (40%), Gaps = 29/289 (10%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQ 1161
E+PP I L +KV + F +E+ +G + V+W+++ S ++ I++ G
Sbjct: 5180 EMPPSFIEPLTKRKVYENTTLGFIVEV-EGLPVPGVKWYRNKSLLEPDERIKMERVGNVC 5238
Query: 1162 KLKIYDCDLDDAGEYSCE----VGNSKCTA---ILTVEE------PSI------NFTLRL 1202
L+I + + GEY C +G +K A I+ EE P + F L
Sbjct: 5239 SLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEH 5298
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
P+ + L VE+ ++ DV ++K+ I +FT D K + + +
Sbjct: 5299 TTSSRTPSPQEIVLEVELSEK--DVKEFEKQVKIVTVPEFT--PDHKSMIVSLDVLPFNF 5354
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
K+ +EV E PP+ + +++I SD P P +W
Sbjct: 5355 VDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWY 5414
Query: 1323 VNSKIIK--KCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
I+ K+ S + S +L I+ V +D+ Y+ R N G A
Sbjct: 5415 KEYMCIEPDNIKYV-ISEEKGSHTLKIRNVCLSDSATYRCRAVNCVGEA 5462
Score = 45.6 bits (103), Expect = 0.002
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G+ + I G P P V WY+ ++E+ ++ IT + + + I+E S ++T
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 1647 ASNTAGTSSVEVTLKV 1662
A N AGT S L V
Sbjct: 1017 AVNEAGTVSTSCYLAV 1032
Score = 45.6 bits (103), Expect = 0.002
Identities = 40/182 (21%), Positives = 76/182 (41%), Gaps = 6/182 (3%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTH 787
EK+ P ++ + + V +GE+ +V G P+P + W N + + K + DG H
Sbjct: 1837 EKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IH 1895
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
+ I+ K D G + AEN EG+ E + +++ + + E V E
Sbjct: 1896 YLDIVDCKSY-DTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEP 1954
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCV 907
G ++ + PV + T + + +E IT E E + + + G Y+ +
Sbjct: 1955 GKLQFEVQKVDRPVDT-TETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 2013
Query: 908 AS 909
+
Sbjct: 2014 TA 2015
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/90 (25%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTI 1156
A V + PP +++ L+N V +G T E ++ + V W+++ +I+ S Q+T
Sbjct: 934 APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCT 1186
+L I + +D+G ++C N T
Sbjct: 994 QSGIARLMIREAFAEDSGRFTCSAVNEAGT 1023
Score = 43.2 bits (97), Expect = 0.010
Identities = 105/491 (21%), Positives = 175/491 (35%), Gaps = 42/491 (8%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEI--QFSNHIQLTIDGKKQK 1162
P + + + K +G A F++++ G + WF DG +I +++ + + DG Q
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVV-GRPMPETFWFHDGQQIVNDYTHKVVIKEDGT-QS 1514
Query: 1163 LKIYDCDLDDAGEYSC----EVGNSKCTAILTVE--EPSIN--FTLRLPEFILVPANTDA 1214
L I D+GE++ G S + ILTVE E + F +L + +
Sbjct: 1515 LIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSQLE 1574
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTE--KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
+ D+ W K +I + K + + L I D YT ++
Sbjct: 1575 MKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAIN 1634
Query: 1273 --AKSTTKLKVEV-VEFPP-----KIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
+ TT+ KV V VEF K++ YR K + L + + Q ++W
Sbjct: 1635 KAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQ--EQW-EE 1691
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+ K K KP K SL +++ ++ RL D M V L P
Sbjct: 1692 GDLYDKEKQQKPFFKKKLTSL---RLKRFGPAHFECRLTPI---GDPTMVVEWLHDGKPL 1745
Query: 1385 GKPNILEI--DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
N L + + ++ + + + I D T S I K + S+
Sbjct: 1746 EAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHT---SATLIVKDEKSLVE 1802
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
R + E++ A E + + Q P + + + E
Sbjct: 1803 ESQLPEGRKGLQRIEELERM-AHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFR 1861
Query: 1503 CIFGGVPQPKVTWYRDG---KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
C G PQPKV WY +G +K K + Y+ K A N G +
Sbjct: 1862 CRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVI 1921
Query: 1560 ETSCVVGIQQK 1570
E + IQQ+
Sbjct: 1922 EHKVKLEIQQR 1932
Score = 43.2 bits (97), Expect = 0.010
Identities = 26/97 (26%), Positives = 46/97 (47%), Gaps = 1/97 (1%)
Query: 1282 EVVEFPPKIV-DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
++ PPK++ + + R + G + L PQP W N ++K+ + + +
Sbjct: 4152 DITNEPPKMLQEMPKHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVN 4211
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
S L IK V + D+G YK ENN G + ++T+
Sbjct: 4212 CSHQLYIKDVNSQDSGKYKCVAENNSGAVESVSDLTV 4248
Score = 42.7 bits (96), Expect = 0.014
Identities = 19/66 (28%), Positives = 34/66 (51%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
GD ++ +I G P P V W++NG L+ ++++ + + IK++ S KY
Sbjct: 4173 GDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQDSGKYKCV 4232
Query: 1647 ASNTAG 1652
A N +G
Sbjct: 4233 AENNSG 4238
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISD 1247
+T + P+ FT L +++ +T + +V+W++ VI T IS
Sbjct: 1 MTTQAPT--FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF 58
Query: 1248 VKKRT-LIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
R L I T+ + Y+ + A ST +L V+ PP V + +++G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
S V L V P P ++ + I+ + S + SL I + D+G Y +
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
N+ G A + + + P K + ++ I+
Sbjct: 179 TNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQIS 214
Score = 41.9 bits (94), Expect = 0.024
Identities = 26/100 (26%), Positives = 40/100 (40%), Gaps = 4/100 (4%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PPT K V EG + LEC + P P + W + +I + + +S +
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGI---- 997
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
+ L I G +T AVN G S L ++ E+
Sbjct: 998 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEE 1037
Score = 41.1 bits (92), Expect = 0.042
Identities = 24/98 (24%), Positives = 46/98 (46%), Gaps = 2/98 (2%)
Query: 728 KTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPT--KSDGD 785
K ++ PP ++ ++S V +G+S G P+P +TW N+ P+ +
Sbjct: 3937 KRPQRCPPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLE 3996
Query: 786 THSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
+SI L ++EG T N G +T++++ V+
Sbjct: 3997 NYSILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVK 4034
Score = 40.7 bits (91), Expect = 0.056
Identities = 24/77 (31%), Positives = 34/77 (44%), Gaps = 4/77 (5%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYEN---RXXXXXXXXXXXX 1544
K+ + I L C+ G PQP VTW+++G LK K +E
Sbjct: 4166 KHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQD 4225
Query: 1545 XXXYKCIAFNDHGEVET 1561
YKC+A N+ G VE+
Sbjct: 4226 SGKYKCVAENNSGAVES 4242
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 6/93 (6%)
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
+DI P + PK EG I+LEC + P+P + W G ++ +N E
Sbjct: 4151 SDITNEPPKMLQEMPKHARCREGDSIILECLISGEPQPVVTWFQNG--VLLKQNQKFQFE 4208
Query: 686 SDMHMYCS-VLKITNVKKFQEGTYTVVAVNREG 717
+ CS L I +V G Y VA N G
Sbjct: 4209 ---EVNCSHQLYIKDVNSQDSGKYKCVAENNSG 4238
Score = 39.1 bits (87), Expect = 0.17
Identities = 34/142 (23%), Positives = 63/142 (44%), Gaps = 9/142 (6%)
Query: 808 ENSEGIAETSAVITVEEPTEENAEP-----PLFINRFQEITVKEKGTIKLVARVTRNPVP 862
E + V+T TEE A P P FI + + E G++ +V NP P
Sbjct: 1052 EEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKP 1111
Query: 863 SITWYRNNEIISPS--ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ W ++ ++ ++ N +LVI+ ++ D+G+Y V N G++S A
Sbjct: 1112 HVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFAD-DAGEYTIVVRNKHGETSASAS 1170
Query: 921 VTIDVEKVTFVKHLQKS-YETE 941
+ + + +K Q+ Y+T+
Sbjct: 1171 LLEEADYELLMKSQQEMLYQTQ 1192
Score = 39.1 bits (87), Expect = 0.17
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNIT-TKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P++ WYK+G ++++ + Y + ++ + +RI + YT ASN G +
Sbjct: 1314 MSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNA 1373
Query: 1655 SVEVTLKVYDKPSKPEG 1671
+ K+Y +P+ P G
Sbjct: 1374 I--CSGKLYVEPAAPLG 1388
Score = 38.7 bits (86), Expect = 0.23
Identities = 23/112 (20%), Positives = 43/112 (38%), Gaps = 4/112 (3%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXX 1537
P+ + +++ + C F G PQP VTWY + + + + EN
Sbjct: 3944 PSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLENYSILTL 4003
Query: 1538 XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDE 1589
C+ FN +G V+T+ ++ ++ K + + H DE
Sbjct: 4004 SSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDVKAHKVPVFHDYLDE 4055
Score = 38.3 bits (85), Expect = 0.30
Identities = 39/181 (21%), Positives = 75/181 (41%), Gaps = 12/181 (6%)
Query: 1507 GVPQPKVTWYRDGKKL---KTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G P P+ W+ DG+++ T K + + +A N G
Sbjct: 1482 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1541
Query: 1562 SCVVGIQ--QKPVITISNEDIKQKH-KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK- 1617
S ++ ++ + V + E +K + K G + + G P P+++W KN + + K
Sbjct: 1542 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPNPDIVWLKNSDIIVPHKY 1601
Query: 1618 -EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLKVYDKPSKPEGPVI 1674
+ I + + ++I S+ YT A N AG T+ +V ++V +PE +I
Sbjct: 1602 PKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLI 1661
Query: 1675 M 1675
+
Sbjct: 1662 I 1662
Score = 37.9 bits (84), Expect = 0.39
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+EG+P P V WY+N + LE D+ + + I +++ +Y A N G
Sbjct: 5206 VEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCSLEISNIQKGEGGEYMCHAVNIIG 5262
Score = 37.9 bits (84), Expect = 0.39
Identities = 20/56 (35%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 1598 GIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
GIP PEV WYK +E D +Y I+ ++ + ++I+ + S S+ Y A N G
Sbjct: 5405 GIPTPEVKWYKEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRCRAVNCVG 5460
Score = 37.9 bits (84), Expect = 0.39
Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 2/89 (2%)
Query: 1012 VKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGH 1070
V E P FI+ + D A + + S V W +DG++++ ++ + G
Sbjct: 5509 VVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGRRFTVEESGTG- 5567
Query: 1071 IRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
L+I + DEGEY C+ ++S AE
Sbjct: 5568 FHNLFITSLVKSDEGEYRCVATNKSGMAE 5596
Score = 37.5 bits (83), Expect = 0.52
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 9/109 (8%)
Query: 509 APIFVEKLRPKHT------PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
A +FVE L T P+ T FEC+V + P + W + I+ S+ F++
Sbjct: 2875 AKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVV-Q 2932
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASST-TELIVEAPLSDHGSE 610
+ L+I ED+ +T V N A+ T T +++ + L D +E
Sbjct: 2933 GKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLKDINAE 2981
Score = 37.1 bits (82), Expect = 0.69
Identities = 15/50 (30%), Positives = 24/50 (48%)
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
I E++ + +KN + C G P PK+ WY+DGK++K
Sbjct: 1283 ISESEAVESGFDLRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK 1332
Score = 37.1 bits (82), Expect = 0.69
Identities = 31/119 (26%), Positives = 49/119 (41%), Gaps = 10/119 (8%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS--ETITQNFD--GENI 888
P F + V E + R+ P P +TW+ NN I I D +
Sbjct: 3504 PSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLHHHSS 3563
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI-----DVEKVTFVKHLQKSYETEE 942
L I V DSG Y+ +A NS G + A + + D + + F+K ++++E E
Sbjct: 3564 SLEIKRVQDR-DSGSYRLLAINSEGSAESTASLLVIQKGQDEKYLEFLKRAERTHENVE 3621
Score = 36.7 bits (81), Expect = 0.91
Identities = 20/79 (25%), Positives = 31/79 (39%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
GD +G P P V WY N + ++ + I + E S++ + + + T
Sbjct: 3958 GDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLENYSILTLSSVHHQNEGSITCV 4017
Query: 1647 ASNTAGTSSVEVTLKVYDK 1665
N GT LKV K
Sbjct: 4018 LFNQYGTVKTTSMLKVKAK 4036
Score = 36.3 bits (80), Expect = 1.2
Identities = 30/136 (22%), Positives = 60/136 (44%), Gaps = 12/136 (8%)
Query: 937 SYETEEGKTVILECQT--SHTVSTKWYHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXD 993
S++ EG+T + + T W+H+ ++I + H+ +I+E D
Sbjct: 1465 SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSD 1524
Query: 994 VGVIKCIVKDQ----ETSTMLVVK----ETIPEFIRKLQDFEVKEKDVAILEVEINSE-T 1044
G + +++ S +L V+ + P F+ KL++ +KE ++V
Sbjct: 1525 SGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSQLEMKVRATGNPN 1584
Query: 1045 ADVVWERDGEIIKPKK 1060
D+VW ++ +II P K
Sbjct: 1585 PDIVWLKNSDIIVPHK 1600
Score = 35.9 bits (79), Expect = 1.6
Identities = 18/63 (28%), Positives = 27/63 (42%), Gaps = 4/63 (6%)
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAKATYENRXX----XXXXXXXXXXXXXYKCIAFNDHGE 1558
C+ G P+P V WY+DGK ++ + T E Y+C+A N G
Sbjct: 5535 CLVRGSPRPTVYWYKDGKLVQGRRFTVEESGTGFHNLFITSLVKSDEGEYRCVATNKSGM 5594
Query: 1559 VET 1561
E+
Sbjct: 5595 AES 5597
Score = 35.5 bits (78), Expect = 2.1
Identities = 22/98 (22%), Positives = 42/98 (42%), Gaps = 3/98 (3%)
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+QKP I + E ++ G+ + G P P+V WY NG + K + + +
Sbjct: 1838 KQKPDIVLYPEPVRVLE--GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV-RYDGI 1894
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
+ I + K + + + A N G +V L++ +
Sbjct: 1895 HYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQR 1932
>AC023270-1|AAX88844.1| 5604|Homo sapiens unknown protein.
Length = 5604
Score = 181 bits (440), Expect = 3e-44
Identities = 176/746 (23%), Positives = 300/746 (40%), Gaps = 44/746 (5%)
Query: 795 KKVKDEGVYTLKA---ENSEGIAETSAV-ITVEEPTEENAEP----PLFINRFQEITVKE 846
+K KDE ++ K E + +AE + I +P + P P R Q TV +
Sbjct: 2032 RKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQ 2091
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENI-ELVITNVDSEIDSGDYK 905
RV P P WY+N I S+ I + +N+ ELVI +V +E DS
Sbjct: 2092 GSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAE-DSASIM 2150
Query: 906 CVASNSAGKSSHGARVTIDVEK-VTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHN 963
A N AG++S A + + ++ +TF + LQ E+ EC+TS V KWY +
Sbjct: 2151 VKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKD 2210
Query: 964 KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE---TSTMLVVKETIPEFI 1020
E+ D + + + D C++ + E T+ L+V+ + EF+
Sbjct: 2211 GMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAKLIVEGAVVEFV 2270
Query: 1021 RKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTS 1080
++LQD EV E LE ++ E + W + +K KY R + L +++ +
Sbjct: 2271 KELQDIEVPESYSGELECIVSPENIEGKWYHNDVELK-SNGKYTITSRRGRQNLTVKDVT 2329
Query: 1081 VHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWF 1140
D+GEYS ++ + T ++ + P I+ L +QKV +G+ E++++ W
Sbjct: 2330 KEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWM 2389
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL 1200
KDG E+Q S+ + + ID + L I D +DAG YS + + V S++
Sbjct: 2390 KDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVIT 2449
Query: 1201 RLPEFILVPANTDAYL--TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC 1258
L + + V T A L V +PD T V WY I+ ++ I K+ L+I +
Sbjct: 2450 PLKD-VNVIEGTKAVLECKVSVPDVT-SVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRT 2507
Query: 1259 TEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
D+ Y ++ ++ L VE + KI+ R+ +V V+ + +
Sbjct: 2508 HASDEGPYKLIVGRVETNCNLSVEKI----KIIRGLRDLTCTETQNVVFEVEL-SHSGID 2562
Query: 1319 DEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL 1378
W K IK K K LT+ + D G Y N + + +
Sbjct: 2563 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAI 2622
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT 1438
KP + E + P++ G EW+
Sbjct: 2623 SKPLT--DQTVAESQEAVFECEVANPDSKG-----------------EWLRDGKHLPLTN 2663
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNED 1498
+I++ R A DI + + K + K+++ ++K LKN+T +D
Sbjct: 2664 NIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD 2723
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKT 1524
T V W ++G L++
Sbjct: 2724 AVFTVELTHPNVKGVQWIKNGVVLES 2749
Score = 179 bits (436), Expect = 9e-44
Identities = 244/1076 (22%), Positives = 412/1076 (38%), Gaps = 92/1076 (8%)
Query: 645 VDEGSDILLECRLVAIPE-PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG+ +LEC+ V++P+ + W E+I PD+ + ++ L I
Sbjct: 2456 VIEGTKAVLECK-VSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQR----LVINRTHAS 2510
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
EG Y ++ E +L + KIK +I L+ + + ++V+ ++ +
Sbjct: 2511 DEGPYKLIVGRVETNCNLSVE-KIK--------IIRGLRDLTCTETQNVVFEVEL-SHSG 2560
Query: 764 PTITWC---KNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+ W K KP ++ G + +T+L K DEG YT A G TS +
Sbjct: 2561 IDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMK-DDEGKYTFYA----GENMTSGKL 2615
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV PL + TV E V NP W R+ + + + I
Sbjct: 2616 TVAGGA---ISKPL-----TDQTVAESQEAVFECEVA-NPDSKGEWLRDGKHLPLTNNIR 2666
Query: 881 QNFDGENIELVI--TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
DG L+I T +D +I YK S ++ K + VE V K L+
Sbjct: 2667 SESDGHKRRLIIAATKLD-DIGEYTYKVATSKTSAK--------LKVEAVKIKKTLKNLT 2717
Query: 939 ETEEGKTVI-LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
TE V +E + +W N + + I +G D V
Sbjct: 2718 VTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVY 2777
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
+ S L V ET+ + I+K +D E EV ++ +T V W IK
Sbjct: 2778 GFRLGRLGASARLHV-ETV-KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIK 2835
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
P +K+ + KL ++N S D GEY+ ++ C A++ V L I ++N +
Sbjct: 2836 PS-DKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL--HITKTMKNIE 2892
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + A+FE E++ + W K+G EI+ S ++ + GK +L I + +D+ EY+
Sbjct: 2893 VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT 2952
Query: 1178 CEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE 1237
GN + +A LTV I T L + +T + V + E + W K I+
Sbjct: 2953 FVCGNDQVSATLTVTP--IMITSMLKDINAEEKDTITF-EVTVNYEGISYKWLKNGVEIK 3009
Query: 1238 DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV--VEFPPKIVDYER 1295
T+K + + +L IR D +YT V A ST L VE +EF I D +
Sbjct: 3010 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDI-K 3068
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDA 1355
KR + + P +W+ + + ++ K + L I +DA
Sbjct: 3069 VLEKKRAMFECEVSE----PDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 3124
Query: 1356 GIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
G Y + N A + + + S + ++E + + +E + +
Sbjct: 3125 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 3184
Query: 1416 VVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+ +Q + +++ + I + S Y F A + S T Y
Sbjct: 3185 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGR-------NRSSVTLYVNAP- 3236
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENR 1532
+ P V + L+ +T + + + G PQPK++WY++ + L T K ++ +
Sbjct: 3237 ----EPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQ 3292
Query: 1533 XXXXXXXXXX-XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A ND+G TS + ++ V++ E +
Sbjct: 3293 EYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQ 3352
Query: 1592 VTAVIEGIPPP----------EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
T EG P +V WY K++ + + +T E T + I E
Sbjct: 3353 DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 3412
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLE 1697
YT ASN G S L + PE I+ E + + +E K +G E
Sbjct: 3413 TYTFVASNAVGQVSSTANLSL----EAPES--ILHERIEQEIEMEMKELFSEGESE 3462
Score = 179 bits (435), Expect = 1e-43
Identities = 155/561 (27%), Positives = 248/561 (44%), Gaps = 26/561 (4%)
Query: 804 TLKAENSEGIAETSAVITVEEPT---EENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
T+K E E S VI ++ T + P + + V E ++L +V+
Sbjct: 2324 TVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLES 2383
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
V + W ++ + + PS+ + D ++ L+I ++ E D+G+Y + G S+ G
Sbjct: 2384 VEGV-WMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKE-DAGNYSFTIP-ALGLSTSGRV 2440
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQE 978
V+ +T +K + EG +LEC+ S S KWY N ++I D + I +
Sbjct: 2441 SVYSVDVITPLKDVN----VIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVK 2496
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
G D G K IV ET+ L V++ + IR L+D E + EV
Sbjct: 2497 GTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI--KIIRGLRDLTCTETQNVVFEV 2554
Query: 1039 EINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA 1098
E++ DV+W + IKP +KY E G I KL + N DEG+Y+ + +
Sbjct: 2555 ELSHSGIDVLWNFKDKEIKPS-SKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSG 2613
Query: 1099 EVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDG 1158
++TV I L +Q V + +A FE E+ D+ W +DG + +N+I+ DG
Sbjct: 2614 KLTVAG--GAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDG 2671
Query: 1159 KKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
K++L I LDD GEY+ +V SK +A L VE I TL+ + V DA TV
Sbjct: 2672 HKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAVKIKKTLK---NLTVTETQDAVFTV 2728
Query: 1219 EIPDETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
E+ + V W K V+E EK+ + +L I+ C D+ Y L ++
Sbjct: 2729 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASA 2788
Query: 1278 KLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
+L VE V KI+ ++ + V V P +W S IK +
Sbjct: 2789 RLHVETV----KIIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHRLV 2843
Query: 1338 IDSKSASLTIKKVENTDAGIY 1358
+ K L ++ + +DAG Y
Sbjct: 2844 SERKVHKLMLQNISPSDAGEY 2864
Score = 177 bits (431), Expect = 4e-43
Identities = 155/678 (22%), Positives = 278/678 (41%), Gaps = 27/678 (3%)
Query: 712 AVNREGEASLPIVLKIK---TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW 768
A+ EG+ ++P K + E P++ E ++S V QG +VVG P P W
Sbjct: 2052 ALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEW 2111
Query: 769 CKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
KN ++ + D +++ +D +KA N G + A + V+
Sbjct: 2112 YKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA- 2170
Query: 826 TEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
+ F Q++ KEK T+ T P + WY++ + + + D
Sbjct: 2171 ----KQLITFTQELQDVVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDR 2226
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+ L I +D+ D+ DY CV + A++ ++ V FVK LQ E E +
Sbjct: 2227 KVHFLSILTIDTS-DAEDYSCVLVEDENVKT-TAKLIVEGAVVEFVKELQ-DIEVPESYS 2283
Query: 946 VILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ 1004
LEC S + KWYHN E+ I D G ++ +
Sbjct: 2284 GELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK 2343
Query: 1005 ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY- 1063
+T+ L +K ++ L D +V E D+ LEV+++ E+ + VW +DG+ ++P +
Sbjct: 2344 KTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHI 2403
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
+K+ H+ L I + + D G YS + + V ++IT L++ V +G K
Sbjct: 2404 VIDKQSHM--LLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTK 2461
Query: 1124 ATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
A E +++ D V+W+ + +I+ + +Q + G KQ+L I D G Y VG
Sbjct: 2462 AVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGR 2521
Query: 1183 SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKF 1242
+ L+VE+ I LR + + VE+ +DV W K I+ + K+
Sbjct: 2522 VETNCNLSVEKIKIIRGLR---DLTCTETQNVVFEVELSHSGIDVLWNFKDKEIKPSSKY 2578
Query: 1243 TLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
+ + K L + +DD+ +YT + ++ KL V + D +
Sbjct: 2579 KIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTD----QTVAES 2634
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
+ + A P EW+ + K + + + D L I + D G Y ++
Sbjct: 2635 QEAVFECEV-ANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKV 2693
Query: 1363 ENNCGHADVEMNVTILDK 1380
+ A +++ + K
Sbjct: 2694 ATSKTSAKLKVEAVKIKK 2711
Score = 177 bits (431), Expect = 4e-43
Identities = 173/747 (23%), Positives = 309/747 (41%), Gaps = 47/747 (6%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
SK Q V E + + EC VA P+ WL G+ + NI ESD H ++
Sbjct: 2623 SKPLTDQTVAESQEAVFECE-VANPDSKGEWLRDGKHLPLTNNIRS--ESDGHKRRLIIA 2679
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
T + E TY V + + V KIK + LK++ V + + + +
Sbjct: 2680 ATKLDDIGEYTYKVATSKTSAKLKVEAV-KIK----------KTLKNLTVTETQDAVFTV 2728
Query: 757 QVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
++ + W KN +++ G +S+ I K + DE VY + G
Sbjct: 2729 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI-KNCAIVDESVYGFRL----GR 2783
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
SA + VE I + +++T E T+ V+ + VP + W+ + I
Sbjct: 2784 LGASARLHVETVK--------IIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEI 2834
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
PS+ + + +L++ N+ S D+G+Y V G+ A++ ++ +T
Sbjct: 2835 KPSDKHRLVSERKVHKLMLQNI-SPSDAGEYTAVV----GQLECKAKLFVETLHIT---K 2886
Query: 934 LQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXX 992
K+ E E KT EC+ SH V + W N EI + +I+ +G+
Sbjct: 2887 TMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE 2946
Query: 993 DVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERD 1052
D + + + S L V + L+D +EKD EV +N E W ++
Sbjct: 2947 DSAEYTFVCGNDQVSATLTVTPIM--ITSMLKDINAEEKDTITFEVTVNYEGISYKWLKN 3004
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR 1112
G IK +K + L IRN D +Y+ + + TA + V E
Sbjct: 3005 GVEIK-STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKH 3063
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+++ KV + +A FE E+++ D V+W KD E+Q ++ I++ + +L I + D
Sbjct: 3064 IKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3123
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
AG+Y+ G + TA L VE + + + + V A + E+ ++ +D WYK
Sbjct: 3124 AGKYTVVAGGNVSTAKLFVEGRDVRIR-SIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3182
Query: 1233 KSVI--EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
I + E+ + + + + I + + D EYT V +S+ L V E PP++
Sbjct: 3183 GIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPE-PPQV 3241
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
+ + ++ G PQP W +++ K D + +L + +
Sbjct: 3242 LQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEA 3301
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTI 1377
DA +Y +N+ G A ++++
Sbjct: 3302 FPEDAAVYTCEAKNDYGVATTSASLSV 3328
Score = 167 bits (407), Expect = 3e-40
Identities = 246/1096 (22%), Positives = 440/1096 (40%), Gaps = 86/1096 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P ++ ++Q V +GSD R+V P+P+ W G +I + I D C
Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPED--NVCE 2135
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
L I +V + V A+N GE S L ++ K+ + L+ ++ ++ +++
Sbjct: 2136 -LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA--KQLITFTQELQDVVAKEKDTMA 2192
Query: 754 LSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
P + W K+ V SD H ++IL D Y+
Sbjct: 2193 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSIL-TIDTSDAEDYSCVLVED 2251
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
E + +T+A + VE E F+ Q+I V E + +L V+ + WY N+
Sbjct: 2252 ENV-KTTAKLIVEGAVVE------FVKELQDIEVPESYSGELECIVSPENIEG-KWYHND 2303
Query: 871 -EIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV 928
E+ S + TIT +N L + +V E D G+Y V GK + ++ + +
Sbjct: 2304 VELKSNGKYTITSRRGRQN--LTVKDVTKE-DQGEYSFVID---GKKT-TCKLKMKPRPI 2356
Query: 929 TFVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
++ L + EG V LE + S +V W + +E+ D I+ + +
Sbjct: 2357 AILQGL-SDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIE 2415
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
D G + ST V + I L+D V E A+LE +++ +
Sbjct: 2416 DMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTS 2475
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELP 1106
V W + E IKP ++ +G ++L I T DEG Y I+ ++V ++
Sbjct: 2476 VKWYLNDEQIKP-DDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNCNLSVEKI- 2533
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVRW-FKDGSEIQFSNHIQLTIDGKKQKLKI 1165
+II L++ + FE+EL+ V W FKD EI+ S+ ++ GK KL +
Sbjct: 2534 -KIIRGLRDLTCTETQNVVFEVELSHSGIDVLWNFKD-KEIKPSSKYKIEAHGKIYKLTV 2591
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
+ DD G+Y+ G + + LTV +I+ L V + +A E+ +
Sbjct: 2592 LNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQ---TVAESQEAVFECEVANPDS 2648
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVE 1285
W + + T SD KR LII DD EYT + +K++ KLKVE V
Sbjct: 2649 KGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAV- 2707
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
KI + + D V+ +WI N +++ + S+ SL
Sbjct: 2708 ---KIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSL 2764
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEM-NVTILDKPSPPGKPNILEIDSSSINICWDEP 1404
IK D +Y RL A + + V I+ KP ++ ++++++
Sbjct: 2765 RIKNCAIVDESVYGFRLGRLGASARLHVETVKIIKKPK-----DVTALENATVAFEVSVS 2819
Query: 1405 ENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDA 1464
+T + VE + D +S + + K +QN+ + + + A V +++
Sbjct: 2820 HDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLM--LQNISPSDAGEYTA-VVGQLECK-- 2874
Query: 1465 SETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
K+ ET + K +KNI + C P + W ++G +++
Sbjct: 2875 ------AKLFVETL----HITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEM 2923
Query: 1525 A---KATYENR-XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDI 1580
+ K + + Y + ND +V + V +IT +DI
Sbjct: 2924 SEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGND--QVSATLTV---TPIMITSMLKDI 2978
Query: 1581 KQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHS 1640
+ K + VT EGI W KNG ++++ + + TK+ T + I+ + +
Sbjct: 2979 NAEEKDTITFEVTVNYEGI---SYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDA 3035
Query: 1641 SKYTIEASNTAGTSSVEVTLKVYD--------KPSKPEGPVIMREISRESVTIEWKPPLD 1692
+ YT A T+++ V + + K + + + E+S +T++W D
Sbjct: 3036 ADYTFVAGKATSTATLYVEARHIEFRKHIKDIKVLEKKRAMFECEVSEPDITVQWMK--D 3093
Query: 1693 DGGLELT-KYAIEKHE 1707
D L++T + I+K +
Sbjct: 3094 DQELQITDRIKIQKEK 3109
Score = 133 bits (322), Expect = 6e-30
Identities = 159/677 (23%), Positives = 272/677 (40%), Gaps = 67/677 (9%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
KKPK E + + E + P + W K EI P + + E +H L +
Sbjct: 2799 KKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHRLVSERKVHK----LML 2853
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
N+ G YT V E +A L + E + + +K++ V + ++ +
Sbjct: 2854 QNISPSDAGEYTAVVGQLECKAKLFV---------ETLHITKTMKNIEVPETKTASFECE 2904
Query: 758 VVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V P++ W KN ++ G H + I+ +D YT N +
Sbjct: 2905 VSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTS-TEDSAEYTFVCGNDQ--- 2959
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
SA +TV P + + ++I +EK TI V + S W +N I
Sbjct: 2960 -VSATLTVT--------PIMITSMLKDINAEEKDTITFEVTVNYEGI-SYKWLKNGVEIK 3009
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL 934
++ L I NV D+ DY VA GK++ A + ++ + F KH+
Sbjct: 3010 STDKCQMRTKKLTHSLNIRNVHFG-DAADYTFVA----GKATSTATLYVEARHIEFRKHI 3064
Query: 935 QKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD 993
K + E K + EC+ S ++ +W + +E+ D +I +E D
Sbjct: 3065 -KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 3123
Query: 994 VGVIKCIVKDQETSTMLVVKETIPEFIRKLQ-DFEVKEKDVAILEVEINSETADVVWERD 1052
G +V ST + E IR ++ + +V EK A++E E+N + D W +D
Sbjct: 3124 AGKYT-VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 3182
Query: 1053 GEIIK---PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL-RDESCTAEVTVVELPPE 1108
G I +++KY E+R H +++I T D GEY+ + R+ S PP+
Sbjct: 3183 GIEINFQVQERHKYVVERRIH--RMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQ 3240
Query: 1109 IITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
++ LQ V G A F ++ + + W+K+ + + DG++ L + +
Sbjct: 3241 VLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIE 3300
Query: 1168 CDLDDAGEYSCEVGN----SKCTAILTVEEPSI-NFTLRLPEF---ILVPANTD------ 1213
+DA Y+CE N + +A L+VE P + + +P + I+ P
Sbjct: 3301 AFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQ 3360
Query: 1214 -AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
A + L V+WY K I+ + F + L I + +D+ YT V +
Sbjct: 3361 PARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASN 3420
Query: 1273 A----KSTTKLKVEVVE 1285
A ST L +E E
Sbjct: 3421 AVGQVSSTANLSLEAPE 3437
Score = 108 bits (260), Expect = 2e-22
Identities = 106/448 (23%), Positives = 177/448 (39%), Gaps = 41/448 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P V L+ +G +V EC + GYP P +TW+R+ I+ S DFQ+ + +A L+
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF-QSGIARLM 1001
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXXXXXXXXAD 627
IRE F ED+G FTC A N AG S++ L V+ + +T D
Sbjct: 1002 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRD 1061
Query: 628 IL--------------EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEE 673
++ E P F KP Q + EG ++ C++ P+P + W G
Sbjct: 1062 VVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVP 1121
Query: 674 IVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE 733
+ V+ V+ +T G YT+V N+ GE S L E +
Sbjct: 1122 LTTGYRYKVSYNKQTGECKLVISMTFAD--DAGEYTIVVRNKHGETSASASL---LEEAD 1176
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
+++ + M+ + + + VG P + + K + T++
Sbjct: 1177 YELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVV 1236
Query: 794 PKKVKDEGVYTLKAENS--EGIAETSAVITVEEPTEENAEPPL-------------FINR 838
V+D+ + E + I T+EE EE+ E + F +R
Sbjct: 1237 RTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSR 1296
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF--DGENIELVITNVD 896
+ + E + +++ P+P I WY++ + I E +F DG L I V
Sbjct: 1297 IKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDG-RASLRIPVVL 1355
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTID 924
E D G Y ASN G + ++ ++
Sbjct: 1356 PE-DEGIYTAFASNIKGNAICSGKLYVE 1382
Score = 93.9 bits (223), Expect = 6e-18
Identities = 69/268 (25%), Positives = 122/268 (45%), Gaps = 19/268 (7%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
I+ ++ G YT VA +L + EPPQV++ L+ + V+ G+ A
Sbjct: 3207 ISETRQSDAGEYTFVAGRNRSSVTLYV------NAPEPPQVLQELQPVTVQSGKPARFCA 3260
Query: 757 QVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
+ G P+P I+W K + + DG +++ +++ +D VYT +A+N G+
Sbjct: 3261 VISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFP-EDAAVYTCEAKNDYGV 3319
Query: 814 AETSAVITVEEPT------EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
A TSA ++VE P E PP I Q+ E + RV+ + ++WY
Sbjct: 3320 ATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWY 3378
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
++ I PS + +L I E D G Y VASN+ G+ S A ++++ +
Sbjct: 3379 SKDKKIKPSRFFRMTQFEDTYQLEIAEAYPE-DEGTYTFVASNAVGQVSSTANLSLEAPE 3437
Query: 928 VTFVKHLQKSYETEEGKTVILECQTSHT 955
+ +++ E E K + E ++ H+
Sbjct: 3438 SILHERIEQEIEMEM-KELFSEGESEHS 3464
Score = 91.5 bits (217), Expect = 3e-17
Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA--LP----TKSDGDT 786
+ P +PL+S++V +G + A + G P P ++W ++ + + LP + SDG
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
+TI K + G Y+LKA N G A ++A + V+ T PP F+ R Q +TV++
Sbjct: 64 -KLTIPAVTKA-NSGRYSLKATNGSGQATSTAELLVKAETA----PPNFVQRLQSMTVRQ 117
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
++L RVT P P + +YR+ I S + +G+ L+I E DSG Y
Sbjct: 118 GSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPE-DSGTYSV 176
Query: 907 VASNSAGKSSHGARVTIDVEK 927
A+NS G+++ A + + E+
Sbjct: 177 NATNSVGRATSTAELLVQGEE 197
Score = 91.5 bits (217), Expect = 3e-17
Identities = 58/201 (28%), Positives = 101/201 (50%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTH 787
+P V++P+ S +G++ +VVG P P W + + + + K DG T
Sbjct: 1456 KPVFVLKPV-SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG-TQ 1513
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
S+ I+ P D G +T+ A+N G + S ++TVE E+ P+F+ + + + +KE
Sbjct: 1514 SLIIV-PATPSDSGEWTVVAQNRAGRSSISVILTVE--AVEHQVKPMFVEKLKNVNIKEG 1570
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEI--DSGDYK 905
+++ R T NP P I W +N++II P + +G E + +DS + DS Y
Sbjct: 1571 SRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL-KIDSTVSQDSAWYT 1629
Query: 906 CVASNSAGKSSHGARVTIDVE 926
A N AG+ + +V ++VE
Sbjct: 1630 ATAINKAGRDTTRCKVNVEVE 1650
Score = 88.2 bits (209), Expect = 3e-16
Identities = 61/202 (30%), Positives = 99/202 (49%), Gaps = 9/202 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYC 692
PTF++ ++ V EGS E + P P+++W G+ I V I SD
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR--- 62
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L I V K G Y++ A N G+A+ L +K E PP ++ L+SM VRQG V
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-ETAPPNFVQRLQSMTVRQGSQV 121
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L +V G P P + + ++ +++ +GD +S+ I + +D G Y++ A N
Sbjct: 122 RLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYP-EDSGTYSVNATN 180
Query: 810 SEGIAETSAVITVEEPTEENAE 831
S G A ++A + V+ E A+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAK 202
Score = 86.6 bits (205), Expect = 9e-16
Identities = 156/772 (20%), Positives = 296/772 (38%), Gaps = 84/772 (10%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
+K K V E EC + P + WL G EI E + ++ +H L
Sbjct: 2885 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ----LI 2939
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
I N YT V N + A+L + P + LK + + +++
Sbjct: 2940 IMNTSTEDSAEYTFVCGNDQVSATLTVT---------PIMITSMLKDINAEEKDTITFEV 2990
Query: 757 QVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
V + W KN +K+ ++ THS+ I + D YT A G
Sbjct: 2991 -TVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNI-RNVHFGDAADYTFVA----GK 3044
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A ++A + VE E F ++I V EK V+ P ++ W ++++ +
Sbjct: 3045 ATSTATLYVEARHIE------FRKHIKDIKVLEKKRAMFECEVSE-PDITVQWMKDDQEL 3097
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ I + L+I + D+G Y VA + A++ ++ V ++
Sbjct: 3098 QITDRIKIQKEKYVHRLLIPSTRMS-DAGKYTVVAGGNVST----AKLFVEGRDVR-IRS 3151
Query: 934 LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGM--DHREIIQEGRXXXXXXXXXX 990
++K + E + ++E + + V WY + EI+ + + + E R
Sbjct: 3152 IKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETR 3211
Query: 991 XXDVGVIKCIV-KDQETSTMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVV 1048
D G + +++ + T+ V P+ +++LQ V+ K V +
Sbjct: 3212 QSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKIS 3271
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE------SCTAEVTV 1102
W ++ +++ K F G L + D Y+C +++ S + V V
Sbjct: 3272 WYKEEQLLSTGF-KCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEV 3330
Query: 1103 VEL----------PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
E+ PP IIT LQ+ ++G A F+ ++ D V W+ +I+ S
Sbjct: 3331 PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFF 3390
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANT 1212
++T +L+I + +D G Y+ N A+ V + N +L PE IL +
Sbjct: 3391 RMTQFEDTYQLEIAEAYPEDEGTYTFVASN----AVGQVSS-TANLSLEAPESIL---HE 3442
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
+E+ + L + S + + F+ D+ +++ ++ Y +
Sbjct: 3443 RIEQEIEMEMKELFSEGESEHSERDTRDAFSDSEDIDHKSMAAKR--------YASRISS 3494
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII---- 1328
S + F P + G V A P P W N++ I
Sbjct: 3495 TSSWPEY------FKPSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGL 3548
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
++ + + S+SL IK+V++ D+G Y+L N+ G A+ ++ ++ K
Sbjct: 3549 RRIIKAESDLHHHSSSLEIKRVQDRDSGSYRLLAINSEGSAESTASLLVIQK 3600
Score = 85.8 bits (203), Expect = 2e-15
Identities = 61/211 (28%), Positives = 94/211 (44%), Gaps = 9/211 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F KP + EG + ++V P P+ W G++IV D V I+ D
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE-PPQVIEPLKSMIVRQGESV 752
++ T G +TVVA NR G +S+ ++L ++ E + P +E LK++ +++G +
Sbjct: 1517 IVPAT---PSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRL 1573
Query: 753 ILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKV-KDEGVYTLKAE 808
+ + GNP P I W KN+ P K + +G + V +D YT A
Sbjct: 1574 EMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAI 1633
Query: 809 NSEGIAETSAVITVE-EPTEENAEPPLFINR 838
N G T + VE E E E L I R
Sbjct: 1634 NKAGRDTTRCKVNVEVEFAEPEPERKLIIPR 1664
Score = 83.0 bits (196), Expect = 1e-14
Identities = 75/292 (25%), Positives = 118/292 (40%), Gaps = 21/292 (7%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
EP ++N PP FI + V E T+ + V PVP + WYRN ++ P E I
Sbjct: 5175 EP-KDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMER 5233
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI--DVEKVTFV------KHLQ 935
G L I+N+ + G+Y C A N G++ A V I E+V + +H+
Sbjct: 5234 VGNVCSLEISNIQKG-EGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVM 5292
Query: 936 K-------SYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ S T + ++LE + S K + + +I + +
Sbjct: 5293 EFDLEHTTSSRTPSPQEIVLEVELSEK-DVKEFEKQVKIVTVPEFTPDHKSMIVSLDVLP 5351
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVE-INSETADV 1047
D + +D+E L V E P FI + DF++ E A+ + I T +V
Sbjct: 5352 FNFVDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEV 5411
Query: 1048 VWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
W ++ I+P KY + L IRN + D Y C R +C E
Sbjct: 5412 KWYKEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRC--RAVNCVGE 5461
Score = 80.2 bits (189), Expect = 7e-14
Identities = 65/245 (26%), Positives = 104/245 (42%), Gaps = 31/245 (12%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
E+ P+FV K +G T +F+ +V G P P+ WF I ++ +D
Sbjct: 1452 ERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDG 1511
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I P D+G +T VA+N AG +S + L VEA
Sbjct: 1512 TQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA---------------------- 1549
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
+ + P F +K K + EGS + ++ R P PDI WL + IVP + + I
Sbjct: 1550 ---VEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRI 1606
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSM 744
E + LKI + YT A+N+ G + + ++ EP EP + +
Sbjct: 1607 EGTKGE--AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEP----EPERKL 1660
Query: 745 IVRQG 749
I+ +G
Sbjct: 1661 IIPRG 1665
Score = 77.8 bits (183), Expect = 4e-13
Identities = 65/247 (26%), Positives = 105/247 (42%), Gaps = 29/247 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +++L+P G +F + G P+P+I+W+++ ++ + +D TL+
Sbjct: 3239 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEY-TLL 3297
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP-LSDHGSEMTVXXXXXXXXXXXXADI 628
+ E FPEDA +TC AKN G A+++ L VE P + EM V
Sbjct: 3298 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPV--------------- 3342
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
PP + EG +CR V+ + ++W K ++I P + D
Sbjct: 3343 ---YPPAIITPLQDTVTSEGQPARFQCR-VSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT 3398
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE----KEPPQVIEPLKSM 744
+ L+I EGTYT VA N G+ S L ++ E + Q IE
Sbjct: 3399 YQ----LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKE 3454
Query: 745 IVRQGES 751
+ +GES
Sbjct: 3455 LFSEGES 3461
Score = 76.2 bits (179), Expect = 1e-12
Identities = 64/231 (27%), Positives = 104/231 (45%), Gaps = 35/231 (15%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ--DFQMYYDDDN 564
+ AP F + L+ +GST FE + G+P P+++WFR +I S Q+ + D
Sbjct: 3 TQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
A L I V ++G ++ A N +G A+ST +E+ V
Sbjct: 63 -AKLTIPAVTKANSGRYSLKATNGSGQATST-------------AELLVKA--------- 99
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
E PP F ++ ++ V +GS + L+ R+ IP P + + G EI + ++
Sbjct: 100 -----ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQ 154
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP 735
E D++ L I GTY+V A N G A+ L ++ GE+E P
Sbjct: 155 EGDLYS----LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ-GEEEVP 200
Score = 73.7 bits (173), Expect = 6e-12
Identities = 41/112 (36%), Positives = 60/112 (53%), Gaps = 2/112 (1%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
++P P E P + L+ T +G +F+C+V G +++W+ + IKPS
Sbjct: 3329 EVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPS 3387
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ F+M +D L I E +PED GT+T VA NA G SST L +EAP S
Sbjct: 3388 RFFRMTQFEDTYQ-LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPES 3438
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 1/96 (1%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
++ P FV++L+ GS V+ + +V G P P + ++R A I+ S DFQ+ + D +
Sbjct: 100 ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD-L 158
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+L+I E +PED+GT++ A N+ G A+ST EL+V+
Sbjct: 159 YSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 72.1 bits (169), Expect = 2e-11
Identities = 78/323 (24%), Positives = 139/323 (43%), Gaps = 27/323 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP+F ++ ++Q V EG C P+P + W + + +P N + I S + Y
Sbjct: 3943 PPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTW-YNNDMPIP-RNQNFIIHS-LENY- 3998
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGE 750
S+L +++V EG+ T V N+ G +LK+K +K + + + + E
Sbjct: 3999 SILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDVKAHKVPVFHDYLDEEEE 4058
Query: 751 SVILSAQVVG-NPRPTITWCKNNKPVKALP-TKSDGDTH--------SITILKPKKVKD- 799
++ Q G +P + N +K P GDT +T P +D
Sbjct: 4059 LALVFDQAKGAHPSMSQEGQTNLHLLKTNPPVPPSGDTELLSFPVEIQVTAATPIPEQDK 4118
Query: 800 EGVYTLKAENSEGIAETSAVITVEEP------TEENAEPPLFINRF-QEITVKEKGTIKL 852
E + E E A +T ++ EPP + + +E +I L
Sbjct: 4119 ESKEVFQTEELEPKAMPQDQVTQSPKHRFVFLSDITNEPPKMLQEMPKHARCREGDSIIL 4178
Query: 853 VARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSA 912
++ P P +TW++N ++ ++ + +L I +V+S+ DSG YKCVA N++
Sbjct: 4179 ECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQ-DSGKYKCVAENNS 4237
Query: 913 GKSSHGARVTIDVEKVTFVKHLQ 935
G + +T VE VT+ ++ Q
Sbjct: 4238 GAVESVSDLT--VEPVTYRENSQ 4258
Score = 70.1 bits (164), Expect = 8e-11
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 1/105 (0%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E P+F++K +YV EG ++ CRL+A P P++ W I + ESD+H
Sbjct: 3500 EYFKPSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLH 3559
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKE 733
+ S L+I V+ G+Y ++A+N EG A S +L I+ G+ E
Sbjct: 3560 HHSSSLEIKRVQDRDSGSYRLLAINSEGSAESTASLLVIQKGQDE 3604
Score = 67.3 bits (157), Expect = 6e-10
Identities = 37/104 (35%), Positives = 56/104 (53%), Gaps = 2/104 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE +++ F +++ +G V F C++ GYP P+I W++ IK + +QM +
Sbjct: 1284 SESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQ 1343
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE--APL 604
D A+L I V PED G +T A N G A + +L VE APL
Sbjct: 1344 DGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPL 1387
Score = 65.7 bits (153), Expect = 2e-09
Identities = 54/185 (29%), Positives = 83/185 (44%), Gaps = 9/185 (4%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNK-YDFEKRGHIRKL 1074
P F + LQ V E A E I+ +V W RDG++I KL
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1075 YIRNTSVHDEGEYSCILRDES----CTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEI 1128
I + + G YS + S TAE+ V PP + RLQ+ V +G++ ++
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 1129 ELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
+T +V++++DG+EIQ S Q++ +G L I + +D+G YS NS A
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 1188 ILTVE 1192
T E
Sbjct: 186 TSTAE 190
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/87 (35%), Positives = 54/87 (62%), Gaps = 5/87 (5%)
Query: 518 PKHTP--DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA-TLVIREVF 574
PKH +G ++ EC + G P+P +TWF+ ++K +Q FQ +++ N + L I++V
Sbjct: 4165 PKHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQ--FEEVNCSHQLYIKDVN 4222
Query: 575 PEDAGTFTCVAKNAAGFASSTTELIVE 601
+D+G + CVA+N +G S ++L VE
Sbjct: 4223 SQDSGKYKCVAENNSGAVESVSDLTVE 4249
Score = 64.1 bits (149), Expect = 5e-09
Identities = 63/276 (22%), Positives = 119/276 (43%), Gaps = 32/276 (11%)
Query: 337 EKTELEQPLFSYEDIVESKKDENEIIQEKQTL--EELPKEDVPEQYTITPRKSSAQKIDE 394
+ E E+ S++ IV+ + + EI ++ L E LPK+ + + + + +++E
Sbjct: 3782 QNIESEELPTSFQTIVDEEIFQTEIRMSQEALVKESLPKDHLYGEILVNENTQARGQLEE 3841
Query: 395 IVDEVTIKKRLNPF-------EIFYTPVEVRCGDTVFAVYSYVAETDEAINLVEGERLYI 447
I+ TI + E++ TP V T A S+ +N+ E E +
Sbjct: 3842 IMANTTIGESSTYITNVCEKEEVYETPENVSQAITPHASESF----GTLVNVEESEEIAS 3897
Query: 448 LDTSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEE-Q 506
D +Q + A +DE K +K + + FE + Q
Sbjct: 3898 ERIKKDDLRELQ---------LSASTRIDEF--------KTEQKEENMRFFENSFRKRPQ 3940
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
P F++++ + +G + F C +GYP+P +TW+ I +Q+F + + +N +
Sbjct: 3941 RCPPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNF-IIHSLENYS 3999
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
L + V ++ G+ TCV N G +T+ L V+A
Sbjct: 4000 ILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKA 4035
Score = 63.7 bits (148), Expect = 7e-09
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 2/110 (1%)
Query: 495 LPVFEKPTSE-EQSM-APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKP 552
+P F+ E SM AP E+++ + GS F +V G P P+ W++ I+
Sbjct: 2061 IPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIER 2120
Query: 553 SQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
S Y+ +DNV LVIR+V ED+ + A N AG SS L+V+A
Sbjct: 2121 SDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQA 2170
Score = 58.8 bits (136), Expect = 2e-07
Identities = 107/460 (23%), Positives = 186/460 (40%), Gaps = 73/460 (15%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
++ M P F+E L + + +T+ F +VEG P P + W+R ++++P + +M
Sbjct: 5177 KDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKM-ERVG 5235
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
NV +L I + + G + C A N G A S + + E V
Sbjct: 5236 NVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQ-----EERVVALPPPVTHQH 5290
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
LE T S+ P Q +I+LE V + E D+ K +IV +
Sbjct: 5291 VMEFDLE--HTTSSRTPSPQ------EIVLE---VELSEKDVKEFEKQVKIVTVPEFTPD 5339
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE-ASLPIVLKIKTGEKEPPQVIEPLK 742
+S M + VL V + +REGE L I L++ + PP+ I P+
Sbjct: 5340 HKS-MIVSLDVLPFNFVDPNMD--------SREGEDKELKIDLEV---FEMPPRFIMPIC 5387
Query: 743 SMIVRQGESVILSAQVVGNPRPTITW-----CKNNKPVKALPTKSDGDTHSITILKPKKV 797
+ + + V+G P P + W C +K + ++ G +H++ I + +
Sbjct: 5388 DFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEKG-SHTLKI-RNVCL 5445
Query: 798 KDEGVYTLKAENSEGIA-----------ETSAVI------TVEEPTEENAEPPLFINRFQ 840
D Y +A N G A E AVI T+ EE + + F
Sbjct: 5446 SDSATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVLKSNYTDSFF 5505
Query: 841 EITVKEKGTIKLVARVT--RNPVPSITWYRNNEIISPSETITQNFDGENIE--------- 889
E V E G + + ++ P+ + +++ SP T+ DG+ ++
Sbjct: 5506 EFQVVE-GPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGRRFTVEES 5564
Query: 890 ------LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
L IT++ + D G+Y+CVA+N +G + A +T+
Sbjct: 5565 GTGFHNLFITSL-VKSDEGEYRCVATNKSGMAESFAALTL 5603
Score = 57.6 bits (133), Expect = 5e-07
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 7/197 (3%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------ATYENRX 1533
Q+PT +PL+++ G P P+V+W+RDG+ + T+ + + R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDEWLV 1592
Y A N G+ ++ + ++ + + ++ + G + +
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ GIP P V +Y++G ++++ ++ I+ + + I E S Y++ A+N+ G
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 1653 TSSVEVTLKVYDKPSKP 1669
++ L V + P
Sbjct: 184 RATSTAELLVQGEEEVP 200
Score = 57.6 bits (133), Expect = 5e-07
Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E+ + AP F+ K + +G +V F CQV G P+P + W + + +++
Sbjct: 1071 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKV 1130
Query: 559 YYD-DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
Y+ LVI F +DAG +T V +N G S++ L+ EA
Sbjct: 1131 SYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEA 1175
Score = 56.4 bits (130), Expect = 1e-06
Identities = 38/136 (27%), Positives = 61/136 (44%), Gaps = 5/136 (3%)
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A+ + V P E PP ++ + +TV E ++ L ++ P P++TWYR + I
Sbjct: 924 AKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQI 983
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
S F L+I +E DSG + C A N AG S + + V + F K
Sbjct: 984 ESSIDFQITFQSGIARLMIREAFAE-DSGRFTCSAVNEAGTVSTSCYLAVQVSE-EFEKE 1041
Query: 934 ---LQKSYETEEGKTV 946
+ + + TEE + V
Sbjct: 1042 TTAVTEKFTTEEKRFV 1057
Score = 56.4 bits (130), Expect = 1e-06
Identities = 66/340 (19%), Positives = 121/340 (35%), Gaps = 29/340 (8%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
E PP ++ + ++ + + +V+ + P P +W N +++ + K S
Sbjct: 5180 EMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCS 5239
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK-------PSPPGKPNILEIDSSSI 1397
L I ++ + G Y N G A NV I+ + P P +++E D
Sbjct: 5240 LEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEHT 5299
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
T + I VE E D E+ VK +T + + + S +
Sbjct: 5300 T-----SSRTPSPQEIVLEVELSEKDVKEFEKQVKIVTVPEFTPDHKSMIVSLDVLPFNF 5354
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY 1516
+ ++ + K+ E P P+ + N D C G+P P+V WY
Sbjct: 5355 VDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWY 5414
Query: 1517 RDGKKLKTAKATY-----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEV---------ETS 1562
++ ++ Y + Y+C A N GE ++
Sbjct: 5415 KEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRCRAVNCVGEAICRGFLTMGDSE 5474
Query: 1563 CVVGIQQKPVITISN--EDIKQKHKVGDEWLVTAVIEGIP 1600
I +K +T+S+ E++ K D + V+EG P
Sbjct: 5475 IFAVIAKKSKVTLSSLMEELVLKSNYTDSFFEFQVVEGPP 5514
Score = 55.6 bits (128), Expect = 2e-06
Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENR 1532
E + PT+ LKN+T E + L C G P P VTWYR+ +++++ + T+++
Sbjct: 937 EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSG 996
Query: 1533 -XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+ C A N+ G V TSC + +Q
Sbjct: 997 IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033
Score = 53.6 bits (123), Expect = 7e-06
Identities = 27/100 (27%), Positives = 48/100 (48%), Gaps = 2/100 (2%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
T +++ P V P +G T +F C+V GYP+P++ W+ +I+ S+ F++ Y
Sbjct: 1833 TDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY- 1891
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
D + L I + D G A+N G +L ++
Sbjct: 1892 -DGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1930
Score = 51.6 bits (118), Expect = 3e-05
Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 5/116 (4%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT--I 791
PP ++ LK++ V +GESV L + G P PT+TW + + +++ I +
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 1001
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
++ +D G +T A N G TS + V+ E E +F T +EK
Sbjct: 1002 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKF---TTEEK 1054
Score = 51.2 bits (117), Expect = 4e-05
Identities = 73/330 (22%), Positives = 129/330 (39%), Gaps = 42/330 (12%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E + F + K + EG + C++ P P IAW G+ I E + D
Sbjct: 1287 EAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGR 1346
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+ L+I V EG YT A N +G A I +G+ +EP +
Sbjct: 1347 ---ASLRIPVVLPEDEGIYTAFASNIKGNA-------ICSGKL----YVEPAAPL---GA 1389
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ I + + V R + P++ P + + P ++ + +
Sbjct: 1390 PTYIPTLEPVSRIRSLSPRSVSRSPIRMSPAR----------MSPARMSPARMSPARMSP 1439
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ ET +E E P+F+ + E T + +V P+P W+ +
Sbjct: 1440 GRRLEET------DESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHD 1493
Query: 870 NEIISPSET--ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID-VE 926
+ I T + DG +++ S DSG++ VA N AG+SS +T++ VE
Sbjct: 1494 GQQIVNDYTHKVVIKEDGTQSLIIVPATPS--DSGEWTVVAQNRAGRSSISVILTVEAVE 1551
Query: 927 ---KVTFVKHLQKSYETEEGKTVILECQTS 953
K FV+ L K+ +EG + ++ + +
Sbjct: 1552 HQVKPMFVEKL-KNVNIKEGSRLEMKVRAT 1580
Score = 50.8 bits (116), Expect = 5e-05
Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 3/94 (3%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD---NVA 566
P F +KL K+ +G V F C++ P P++TWF I + + D + +
Sbjct: 3504 PSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLHHHSS 3563
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+L I+ V D+G++ +A N+ G A ST L+V
Sbjct: 3564 SLEIKRVQDRDSGSYRLLAINSEGSAESTASLLV 3597
Score = 49.6 bits (113), Expect = 1e-04
Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 3/118 (2%)
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+ E E +A A+ V +E +P + + + + V E T + RVT P P +
Sbjct: 1815 RIEELERMAHEGALTGVTTDQKEKQKPDIVLYP-EPVRVLEGETARFRCRVTGYPQPKVN 1873
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
WY N ++I S+ +DG + L I + S D+G+ K A N G H ++ I
Sbjct: 1874 WYLNGQLIRKSKRFRVRYDGIHY-LDIVDCKS-YDTGEVKVTAENPEGVIEHKVKLEI 1929
Score = 49.2 bits (112), Expect = 2e-04
Identities = 29/90 (32%), Positives = 50/90 (55%), Gaps = 3/90 (3%)
Query: 1029 KEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEY 1087
+E D ILE I+ E VV W ++G ++K + K+ FE+ +LYI++ + D G+Y
Sbjct: 4171 REGDSIILECLISGEPQPVVTWFQNGVLLK-QNQKFQFEEVNCSHQLYIKDVNSQDSGKY 4229
Query: 1088 SCILRDESCTAEVTVVELPPEIITRLQNQK 1117
C+ + S E +V +L E +T +N +
Sbjct: 4230 KCVAENNSGAVE-SVSDLTVEPVTYRENSQ 4258
Score = 48.8 bits (111), Expect = 2e-04
Identities = 42/198 (21%), Positives = 80/198 (40%), Gaps = 14/198 (7%)
Query: 1472 KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY-- 1529
K+ +++P + + +++ T D G P P+ WY++G K++ + Y
Sbjct: 2068 KIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWY 2127
Query: 1530 ---ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE--DIKQKH 1584
+N A N GE + + +Q K +IT + E D+ K
Sbjct: 2128 WPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKE 2187
Query: 1585 KVGDEWLVTAVIEGIPP-PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKY 1643
K + + T E P +V WYK+G ++ +Y + + K + I + S + Y
Sbjct: 2188 K---DTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDY 2244
Query: 1644 T---IEASNTAGTSSVEV 1658
+ +E N T+ + V
Sbjct: 2245 SCVLVEDENVKTTAKLIV 2262
Score = 48.0 bits (109), Expect = 4e-04
Identities = 76/333 (22%), Positives = 128/333 (38%), Gaps = 34/333 (10%)
Query: 1090 ILRDESCTAEVTVVELP--PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEI 1146
++ D S T E P P IT+ QK+ +G F ++ V W K G +
Sbjct: 1063 VMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPL 1122
Query: 1147 QFSNHIQLTIDGK--KQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTL 1200
+++ + + + KL I DDAGEY+ V G + +A L +EE +
Sbjct: 1123 TTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL-LEEADYELLM 1181
Query: 1201 RLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
+ + +L A++ ET Y + + E+ + + K T+++R E
Sbjct: 1182 KSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVE 1241
Query: 1261 DDQ-------------CEYTCV------LLDAKSTTKLKVEVVEFPPKIVDYE---REYR 1298
D + EY + LL+ K+ V++ E ++ + YR
Sbjct: 1242 DQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYR 1301
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC-KHTKPSIDSKSASLTIKKVENTDAGI 1357
I G VT +P P W + K IK ++ + ASL I V D GI
Sbjct: 1302 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGI 1361
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
Y N G+A + ++ +P G P +
Sbjct: 1362 YTAFASNIKGNA-ICSGKLYVEPAAPLGAPTYI 1393
Score = 48.0 bits (109), Expect = 4e-04
Identities = 54/243 (22%), Positives = 85/243 (34%), Gaps = 21/243 (8%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVE--GYPRPQITWFRQTAIIKPSQDFQMYYD 561
+E+ P F +KL FEC++ G P + W ++ + +M +
Sbjct: 1697 KEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMI-N 1755
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV--EAPLSDHGS---------- 609
+ +L + D+G TC A N G ++ LIV E L +
Sbjct: 1756 EFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQR 1815
Query: 610 -EMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWL 668
E D E P P+ V EG CR+ P+P + W
Sbjct: 1816 IEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWY 1875
Query: 669 FKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
G+ I + V + +H L I + K + G V A N EG + L+I+
Sbjct: 1876 LNGQLIRKSKRFRVRYDG-IH----YLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQ 1930
Query: 729 TGE 731
E
Sbjct: 1931 QRE 1933
Score = 47.2 bits (107), Expect = 6e-04
Identities = 24/68 (35%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P PE W+ +G ++ ND + + KE T + I S S ++T+ A N AG S
Sbjct: 1480 VVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRS 1539
Query: 1655 SVEVTLKV 1662
S+ V L V
Sbjct: 1540 SISVILTV 1547
Score = 46.8 bits (106), Expect = 9e-04
Identities = 67/289 (23%), Positives = 117/289 (40%), Gaps = 29/289 (10%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQ 1161
E+PP I L +KV + F +E+ +G + V+W+++ S ++ I++ G
Sbjct: 5180 EMPPSFIEPLTKRKVYENTTLGFIVEV-EGLPVPGVKWYRNKSLLEPDERIKMERVGNVC 5238
Query: 1162 KLKIYDCDLDDAGEYSCE----VGNSKCTA---ILTVEE------PSI------NFTLRL 1202
L+I + + GEY C +G +K A I+ EE P + F L
Sbjct: 5239 SLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEH 5298
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
P+ + L VE+ ++ DV ++K+ I +FT D K + + +
Sbjct: 5299 TTSSRTPSPQEIVLEVELSEK--DVKEFEKQVKIVTVPEFT--PDHKSMIVSLDVLPFNF 5354
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
K+ +EV E PP+ + +++I SD P P +W
Sbjct: 5355 VDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWY 5414
Query: 1323 VNSKIIK--KCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
I+ K+ S + S +L I+ V +D+ Y+ R N G A
Sbjct: 5415 KEYMCIEPDNIKYV-ISEEKGSHTLKIRNVCLSDSATYRCRAVNCVGEA 5462
Score = 46.4 bits (105), Expect = 0.001
Identities = 41/158 (25%), Positives = 64/158 (40%), Gaps = 9/158 (5%)
Query: 1229 WYKK-KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK----LKVEV 1283
W+ + ++ D +I + ++LII T D E+T V + + L VE
Sbjct: 1490 WFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA 1549
Query: 1284 VEFP--PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
VE P V+ + IK GS + + V P P+ W+ NS II K+ K I+
Sbjct: 1550 VEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGT 1609
Query: 1342 --SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
A+L I + D+ Y N G V +
Sbjct: 1610 KGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1647
Score = 45.6 bits (103), Expect = 0.002
Identities = 23/76 (30%), Positives = 37/76 (48%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G+ + I G P P V WY+ ++E+ ++ IT + + + I+E S ++T
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 1647 ASNTAGTSSVEVTLKV 1662
A N AGT S L V
Sbjct: 1017 AVNEAGTVSTSCYLAV 1032
Score = 45.6 bits (103), Expect = 0.002
Identities = 40/182 (21%), Positives = 76/182 (41%), Gaps = 6/182 (3%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTH 787
EK+ P ++ + + V +GE+ +V G P+P + W N + + K + DG H
Sbjct: 1837 EKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IH 1895
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
+ I+ K D G + AEN EG+ E + +++ + + E V E
Sbjct: 1896 YLDIVDCKSY-DTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEP 1954
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCV 907
G ++ + PV + T + + +E IT E E + + + G Y+ +
Sbjct: 1955 GKLQFEVQKVDRPVDT-TETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAI 2013
Query: 908 AS 909
+
Sbjct: 2014 TA 2015
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/90 (25%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTI 1156
A V + PP +++ L+N V +G T E ++ + V W+++ +I+ S Q+T
Sbjct: 934 APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITF 993
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCT 1186
+L I + +D+G ++C N T
Sbjct: 994 QSGIARLMIREAFAEDSGRFTCSAVNEAGT 1023
Score = 43.2 bits (97), Expect = 0.010
Identities = 105/491 (21%), Positives = 175/491 (35%), Gaps = 42/491 (8%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEI--QFSNHIQLTIDGKKQK 1162
P + + + K +G A F++++ G + WF DG +I +++ + + DG Q
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVV-GRPMPETFWFHDGQQIVNDYTHKVVIKEDGT-QS 1514
Query: 1163 LKIYDCDLDDAGEYSC----EVGNSKCTAILTVE--EPSIN--FTLRLPEFILVPANTDA 1214
L I D+GE++ G S + ILTVE E + F +L + +
Sbjct: 1515 LIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLE 1574
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTE--KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
+ D+ W K +I + K + + L I D YT ++
Sbjct: 1575 MKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAIN 1634
Query: 1273 --AKSTTKLKVEV-VEFPP-----KIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
+ TT+ KV V VEF K++ YR K + L + + Q ++W
Sbjct: 1635 KAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQ--EQW-EE 1691
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+ K K KP K SL +++ ++ RL D M V L P
Sbjct: 1692 GDLYDKEKQQKPFFKKKLTSL---RLKRFGPAHFECRLTPI---GDPTMVVEWLHDGKPL 1745
Query: 1385 GKPNILEI--DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
N L + + ++ + + + I D T S I K + S+
Sbjct: 1746 EAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHT---SATLIVKDEKSLVE 1802
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELT 1502
R + E++ A E + + Q P + + + E
Sbjct: 1803 ESQLPEGRKGLQRIEELERM-AHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFR 1861
Query: 1503 CIFGGVPQPKVTWYRDG---KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
C G PQPKV WY +G +K K + Y+ K A N G +
Sbjct: 1862 CRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVI 1921
Query: 1560 ETSCVVGIQQK 1570
E + IQQ+
Sbjct: 1922 EHKVKLEIQQR 1932
Score = 43.2 bits (97), Expect = 0.010
Identities = 26/97 (26%), Positives = 46/97 (47%), Gaps = 1/97 (1%)
Query: 1282 EVVEFPPKIV-DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
++ PPK++ + + R + G + L PQP W N ++K+ + + +
Sbjct: 4152 DITNEPPKMLQEMPKHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVN 4211
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
S L IK V + D+G YK ENN G + ++T+
Sbjct: 4212 CSHQLYIKDVNSQDSGKYKCVAENNSGAVESVSDLTV 4248
Score = 42.7 bits (96), Expect = 0.014
Identities = 19/66 (28%), Positives = 34/66 (51%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
GD ++ +I G P P V W++NG L+ ++++ + + IK++ S KY
Sbjct: 4173 GDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQDSGKYKCV 4232
Query: 1647 ASNTAG 1652
A N +G
Sbjct: 4233 AENNSG 4238
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISD 1247
+T + P+ FT L +++ +T + +V+W++ VI T IS
Sbjct: 1 MTTQAPT--FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF 58
Query: 1248 VKKRT-LIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
R L I T+ + Y+ + A ST +L V+ PP V + +++G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
S V L V P P ++ + I+ + S + SL I + D+G Y +
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
N+ G A + + + P K + ++ I+
Sbjct: 179 TNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQIS 214
Score = 41.9 bits (94), Expect = 0.024
Identities = 26/100 (26%), Positives = 40/100 (40%), Gaps = 4/100 (4%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PPT K V EG + LEC + P P + W + +I + + +S +
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGI---- 997
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
+ L I G +T AVN G S L ++ E+
Sbjct: 998 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEE 1037
Score = 41.1 bits (92), Expect = 0.042
Identities = 24/98 (24%), Positives = 46/98 (46%), Gaps = 2/98 (2%)
Query: 728 KTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPT--KSDGD 785
K ++ PP ++ ++S V +G+S G P+P +TW N+ P+ +
Sbjct: 3937 KRPQRCPPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLE 3996
Query: 786 THSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
+SI L ++EG T N G +T++++ V+
Sbjct: 3997 NYSILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVK 4034
Score = 40.7 bits (91), Expect = 0.056
Identities = 24/77 (31%), Positives = 34/77 (44%), Gaps = 4/77 (5%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYEN---RXXXXXXXXXXXX 1544
K+ + I L C+ G PQP VTW+++G LK K +E
Sbjct: 4166 KHARCREGDSIILECLISGEPQPVVTWFQNGVLLKQNQKFQFEEVNCSHQLYIKDVNSQD 4225
Query: 1545 XXXYKCIAFNDHGEVET 1561
YKC+A N+ G VE+
Sbjct: 4226 SGKYKCVAENNSGAVES 4242
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 6/93 (6%)
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
+DI P + PK EG I+LEC + P+P + W G ++ +N E
Sbjct: 4151 SDITNEPPKMLQEMPKHARCREGDSIILECLISGEPQPVVTWFQNG--VLLKQNQKFQFE 4208
Query: 686 SDMHMYCS-VLKITNVKKFQEGTYTVVAVNREG 717
+ CS L I +V G Y VA N G
Sbjct: 4209 ---EVNCSHQLYIKDVNSQDSGKYKCVAENNSG 4238
Score = 39.1 bits (87), Expect = 0.17
Identities = 34/142 (23%), Positives = 63/142 (44%), Gaps = 9/142 (6%)
Query: 808 ENSEGIAETSAVITVEEPTEENAEP-----PLFINRFQEITVKEKGTIKLVARVTRNPVP 862
E + V+T TEE A P P FI + + E G++ +V NP P
Sbjct: 1052 EEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKP 1111
Query: 863 SITWYRNNEIISPS--ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ W ++ ++ ++ N +LVI+ ++ D+G+Y V N G++S A
Sbjct: 1112 HVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFAD-DAGEYTIVVRNKHGETSASAS 1170
Query: 921 VTIDVEKVTFVKHLQKS-YETE 941
+ + + +K Q+ Y+T+
Sbjct: 1171 LLEEADYELLMKSQQEMLYQTQ 1192
Score = 39.1 bits (87), Expect = 0.17
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNIT-TKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P++ WYK+G ++++ + Y + ++ + +RI + YT ASN G +
Sbjct: 1314 MSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNA 1373
Query: 1655 SVEVTLKVYDKPSKPEG 1671
+ K+Y +P+ P G
Sbjct: 1374 I--CSGKLYVEPAAPLG 1388
Score = 38.7 bits (86), Expect = 0.23
Identities = 23/112 (20%), Positives = 43/112 (38%), Gaps = 4/112 (3%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXX 1537
P+ + +++ + C F G PQP VTWY + + + + EN
Sbjct: 3944 PSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLENYSILTL 4003
Query: 1538 XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDE 1589
C+ FN +G V+T+ ++ ++ K + + H DE
Sbjct: 4004 SSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDVKAHKVPVFHDYLDE 4055
Score = 38.3 bits (85), Expect = 0.30
Identities = 43/185 (23%), Positives = 78/185 (42%), Gaps = 20/185 (10%)
Query: 1507 GVPQPKVTWYRDGKKL---KTAKATY--ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G P P+ W+ DG+++ T K + + +A N G
Sbjct: 1482 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1541
Query: 1562 SCVVGI-----QQKPVIT--ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE 1614
S ++ + Q KP+ + N +IK+ ++ E V A G P P+++W KN + +
Sbjct: 1542 SVILTVEAVEHQVKPMFVEKLKNVNIKEGSRL--EMKVRAT--GNPNPDIVWLKNSDIIV 1597
Query: 1615 NDK--EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLKVYDKPSKPE 1670
K + I + + ++I S+ YT A N AG T+ +V ++V +PE
Sbjct: 1598 PHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPE 1657
Query: 1671 GPVIM 1675
+I+
Sbjct: 1658 RKLII 1662
Score = 37.9 bits (84), Expect = 0.39
Identities = 15/50 (30%), Positives = 24/50 (48%)
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
I E++ + +KN + C G P PK+ WY+DGK++K
Sbjct: 1283 ISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK 1332
Score = 37.9 bits (84), Expect = 0.39
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+EG+P P V WY+N + LE D+ + + I +++ +Y A N G
Sbjct: 5206 VEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCSLEISNIQKGEGGEYMCHAVNIIG 5262
Score = 37.9 bits (84), Expect = 0.39
Identities = 20/56 (35%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 1598 GIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
GIP PEV WYK +E D +Y I+ ++ + ++I+ + S S+ Y A N G
Sbjct: 5405 GIPTPEVKWYKEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRCRAVNCVG 5460
Score = 37.9 bits (84), Expect = 0.39
Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 2/89 (2%)
Query: 1012 VKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGH 1070
V E P FI+ + D A + + S V W +DG++++ ++ + G
Sbjct: 5509 VVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGRRFTVEESGTG- 5567
Query: 1071 IRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
L+I + DEGEY C+ ++S AE
Sbjct: 5568 FHNLFITSLVKSDEGEYRCVATNKSGMAE 5596
Score = 37.5 bits (83), Expect = 0.52
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 9/109 (8%)
Query: 509 APIFVEKLRPKHT------PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
A +FVE L T P+ T FEC+V + P + W + I+ S+ F++
Sbjct: 2875 AKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVV-Q 2932
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASST-TELIVEAPLSDHGSE 610
+ L+I ED+ +T V N A+ T T +++ + L D +E
Sbjct: 2933 GKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLKDINAE 2981
Score = 37.1 bits (82), Expect = 0.69
Identities = 31/119 (26%), Positives = 49/119 (41%), Gaps = 10/119 (8%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS--ETITQNFD--GENI 888
P F + V E + R+ P P +TW+ NN I I D +
Sbjct: 3504 PSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLHHHSS 3563
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI-----DVEKVTFVKHLQKSYETEE 942
L I V DSG Y+ +A NS G + A + + D + + F+K ++++E E
Sbjct: 3564 SLEIKRVQDR-DSGSYRLLAINSEGSAESTASLLVIQKGQDEKYLEFLKRAERTHENVE 3621
Score = 36.7 bits (81), Expect = 0.91
Identities = 20/79 (25%), Positives = 31/79 (39%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
GD +G P P V WY N + ++ + I + E S++ + + + T
Sbjct: 3958 GDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLENYSILTLSSVHHQNEGSITCV 4017
Query: 1647 ASNTAGTSSVEVTLKVYDK 1665
N GT LKV K
Sbjct: 4018 LFNQYGTVKTTSMLKVKAK 4036
Score = 35.9 bits (79), Expect = 1.6
Identities = 30/136 (22%), Positives = 60/136 (44%), Gaps = 12/136 (8%)
Query: 937 SYETEEGKTVILECQT--SHTVSTKWYHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXD 993
S++ EG+T + + T W+H+ ++I + H+ +I+E D
Sbjct: 1465 SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSD 1524
Query: 994 VGVIKCIVKDQ----ETSTMLVVK----ETIPEFIRKLQDFEVKEKDVAILEVEINSE-T 1044
G + +++ S +L V+ + P F+ KL++ +KE ++V
Sbjct: 1525 SGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPN 1584
Query: 1045 ADVVWERDGEIIKPKK 1060
D+VW ++ +II P K
Sbjct: 1585 PDIVWLKNSDIIVPHK 1600
Score = 35.9 bits (79), Expect = 1.6
Identities = 18/63 (28%), Positives = 27/63 (42%), Gaps = 4/63 (6%)
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAKATYENRXX----XXXXXXXXXXXXXYKCIAFNDHGE 1558
C+ G P+P V WY+DGK ++ + T E Y+C+A N G
Sbjct: 5535 CLVRGSPRPTVYWYKDGKLVQGRRFTVEESGTGFHNLFITSLVKSDEGEYRCVATNKSGM 5594
Query: 1559 VET 1561
E+
Sbjct: 5595 AES 5597
Score = 35.5 bits (78), Expect = 2.1
Identities = 22/98 (22%), Positives = 42/98 (42%), Gaps = 3/98 (3%)
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+QKP I + E ++ G+ + G P P+V WY NG + K + + +
Sbjct: 1838 KQKPDIVLYPEPVRVLE--GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV-RYDGI 1894
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
+ I + K + + + A N G +V L++ +
Sbjct: 1895 HYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQR 1932
>AJ277892-5|CAD12459.1| 2154|Homo sapiens Titin Novex-1 Isoform
protein.
Length = 2154
Score = 179 bits (436), Expect = 9e-44
Identities = 174/747 (23%), Positives = 309/747 (41%), Gaps = 47/747 (6%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
SK Q V E + + EC VA P+ WL G+ + NI ESD H ++
Sbjct: 179 SKPLTDQTVAESQEAVFECE-VANPDSKGEWLRDGKHLPLTNNIRS--ESDGHKRRLIIA 235
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
T + E TY V + + V KIK + LK++ V + + + +
Sbjct: 236 ATKLDDIGEYTYKVATSKTSAKLKVEAV-KIK----------KTLKNLTVTETQDAVFTV 284
Query: 757 QVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
++ + W KN +++ G +S+ I K + DE VY + G
Sbjct: 285 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI-KNCAIVDESVYGFRL----GR 339
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
SA + VE I + +++T E T+ V+ + VP + W+ N I
Sbjct: 340 LGASARLHVETVK--------IIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKNVEI 390
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
PS+ + + +L++ N+ S D+G+Y V G+ A++ ++ +T
Sbjct: 391 KPSDKHRLVSERKVHKLMLQNI-SPSDAGEYTAVV----GQLECKAKLFVETLHIT---K 442
Query: 934 LQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXX 992
K+ E E KT EC+ SH V + W N EI + +I+ +G+
Sbjct: 443 TMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE 502
Query: 993 DVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERD 1052
D + + + S L V + L+D +EKD EV +N E W ++
Sbjct: 503 DSAEYTFVCGNDQVSATLTVTPIM--ITSMLKDINAEEKDTITFEVTVNYEGISYKWLKN 560
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR 1112
G IK +K + L IRN D +Y+ + + TA + V E
Sbjct: 561 GVEIK-STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKH 619
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+++ KV + +A FE E+++ D V+W KD E+Q ++ I++ + +L I + D
Sbjct: 620 IKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 679
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
AG+Y+ G + TA L VE + + + + V A + E+ ++ +D WYK
Sbjct: 680 AGKYTVVAGGNVSTAKLFVEGRDVRIR-SIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 738
Query: 1233 KSVI--EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
I + E+ + + + + I + + D EYT V +S+ L V E PP++
Sbjct: 739 GIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPE-PPQV 797
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
+ + ++ G PQP W +++ K D + +L + +
Sbjct: 798 LQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEA 857
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTI 1377
DA +Y +N+ G A ++++
Sbjct: 858 FPEDAAVYTCEAKNDYGVATTSASLSV 884
Score = 178 bits (433), Expect = 2e-43
Identities = 239/1046 (22%), Positives = 406/1046 (38%), Gaps = 88/1046 (8%)
Query: 645 VDEGSDILLECRLVAIPE-PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG+ +LEC+ V++P+ + W E+I PD+ + ++ L I
Sbjct: 12 VIEGTKAVLECK-VSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQR----LVINRTHAS 66
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
EG Y ++ E +L V KIK +I L+ + + ++V+ + + +
Sbjct: 67 DEGPYKLIVGRVETNCNLS-VEKIK--------IIRGLRDLTCTETQNVVFEVE-LSHSG 116
Query: 764 PTITW---CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+ W K KP ++ G + +T+L K DEG YT A E I TS +
Sbjct: 117 IDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMK-DDEGKYTFYA--GENI--TSGKL 171
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV PL + TV E V NP W R+ + + + I
Sbjct: 172 TVAGGA---ISKPL-----TDQTVAESQEAVFECEVA-NPDSKGEWLRDGKHLPLTNNIR 222
Query: 881 QNFDGENIELVI--TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
DG L+I T +D +I YK S ++ K + VE V K L+
Sbjct: 223 SESDGHKRRLIIAATKLD-DIGEYTYKVATSKTSAK--------LKVEAVKIKKTLKNLT 273
Query: 939 ETEEGKTVI-LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
TE V +E + +W N + + I +G D V
Sbjct: 274 VTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVY 333
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
+ S L V ET+ + I+K +D E EV ++ +T V W IK
Sbjct: 334 GFRLGRLGASARLHV-ETV-KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIK 391
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
P +K+ + KL ++N S D GEY+ ++ C A++ V L I ++N +
Sbjct: 392 P-SDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL--HITKTMKNIE 448
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + A+FE E++ + W K+G EI+ S ++ + GK +L I + +D+ EY+
Sbjct: 449 VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT 508
Query: 1178 CEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE 1237
GN + +A LTV I T L + +T + V + E + W K I+
Sbjct: 509 FVCGNDQVSATLTV--TPIMITSMLKDINAEEKDTITF-EVTVNYEGISYKWLKNGVEIK 565
Query: 1238 DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV--VEFPPKIVDYER 1295
T+K + + +L IR D +YT V A ST L VE +EF I D +
Sbjct: 566 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDI-K 624
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDA 1355
KR + + P +W+ + + ++ K + L I +DA
Sbjct: 625 VLEKKR----AMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 680
Query: 1356 GIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
G Y + N A + + + S + ++E + + +E + +
Sbjct: 681 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 740
Query: 1416 VVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+ +Q + +++ + I + S Y F V + S T Y
Sbjct: 741 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTF-------VAGRNRSSVTLYVNA-- 791
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENR 1532
+ P V + L+ +T + + + G PQPK++WY++ + L T K ++ +
Sbjct: 792 ---PEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQ 848
Query: 1533 XXXXXXXXXX-XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A ND+G TS + ++ V++ E +
Sbjct: 849 EYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQ 908
Query: 1592 VTAVIEGIPPP----------EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
T EG P +V WY K++ + + +T E T + I E
Sbjct: 909 DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 968
Query: 1642 KYTIEASNTAG--TSSVEVTLKVYDK 1665
YT ASN G +S+ ++L+ + K
Sbjct: 969 TYTFVASNAVGQVSSTANLSLEGFSK 994
Score = 159 bits (387), Expect = 8e-38
Identities = 127/426 (29%), Positives = 190/426 (44%), Gaps = 16/426 (3%)
Query: 936 KSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD 993
K EG +LEC+ S S KWY N ++I D + I +G D
Sbjct: 8 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASD 67
Query: 994 VGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDG 1053
G K IV ET+ L V++ + IR L+D E + EVE++ DV+W
Sbjct: 68 EGPYKLIVGRVETNCNLSVEKI--KIIRGLRDLTCTETQNVVFEVELSHSGIDVLWNFKD 125
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRL 1113
+ IKP +KY E G I KL + N DEG+Y+ + + ++TV I L
Sbjct: 126 KEIKPS-SKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAG--GAISKPL 182
Query: 1114 QNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDA 1173
+Q V + +A FE E+ D+ W +DG + +N+I+ DG K++L I LDD
Sbjct: 183 TDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDI 242
Query: 1174 GEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTWYKK 1232
GEY+ +V SK +A L VE I TL+ + V DA TVE+ + V W K
Sbjct: 243 GEYTYKVATSKTSAKLKVEAVKIKKTLK---NLTVTETQDAVFTVELTHPNVKGVQWIKN 299
Query: 1233 KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
V+E EK+ + +L I+ C D+ Y L ++ +L VE V KI+
Sbjct: 300 GVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVETV----KIIK 355
Query: 1293 YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
++ + V V P + N +I KH S + K L ++ +
Sbjct: 356 KPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKHRLVS-ERKVHKLMLQNISP 414
Query: 1353 TDAGIY 1358
+DAG Y
Sbjct: 415 SDAGEY 420
Score = 149 bits (362), Expect = 8e-35
Identities = 131/544 (24%), Positives = 222/544 (40%), Gaps = 27/544 (4%)
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV 895
I +++ V E L +V+ V S+ WY N+E I P + + G LVI
Sbjct: 4 ITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRT 63
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT 955
+ D G YK + + VEK+ ++ L + E + V+ E + SH+
Sbjct: 64 HAS-DEGPYKLIVGRVE------TNCNLSVEKIKIIRGL-RDLTCTETQNVVFEVELSHS 115
Query: 956 -VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKE 1014
+ W KEI +I G+ D G + TS L V
Sbjct: 116 GIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAG 175
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKL 1074
+ L D V E A+ E E+ + + W RDG+ + P N E GH R+L
Sbjct: 176 --GAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHL-PLTNNIRSESDGHKRRL 232
Query: 1075 YIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGD 1134
I T + D GEY+ + +A++ V + +I L+N V + A F +ELT +
Sbjct: 233 IIAATKLDDIGEYTYKVATSKTSAKLKVEAV--KIKKTLKNLTVTETQDAVFTVELTHPN 290
Query: 1135 AL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
V+W K+G ++ + +++ G L+I +C + D Y +G +A L VE
Sbjct: 291 VKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET 350
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
I ++ P+ + N V + +T+ V W+ K I+ ++K L+S+ K L
Sbjct: 351 VKI---IKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKHRLVSERKVHKL 407
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQA 1313
+++ + D EYT V+ + KL VE + + + E + + +
Sbjct: 408 MLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIE----VPETKTASFECEVSH 463
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
F P+ W+ N I+ + K + K L I D+ Y CG+ V
Sbjct: 464 FNVPS-MWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTF----VCGNDQVSA 518
Query: 1374 NVTI 1377
+T+
Sbjct: 519 TLTV 522
Score = 147 bits (355), Expect = 6e-34
Identities = 203/937 (21%), Positives = 363/937 (38%), Gaps = 66/937 (7%)
Query: 737 VIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD--GDTHSITILKP 794
VI PLK + V +G +L +V ++ W N++ +K T ++
Sbjct: 3 VITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINR 62
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
DEG Y L G ET+ ++VE+ I +++T E +
Sbjct: 63 THASDEGPYKLIV----GRVETNCNLSVEKIK--------IIRGLRDLTCTETQNVVFEV 110
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
++ + + + W ++ I PS G+ +L + N+ + D G Y + AG+
Sbjct: 111 ELSHSGI-DVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKD-DEGKY----TFYAGE 164
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVST-KWYHNKKEISGMDHR 973
+ ++T+ ++ Q E++E + EC+ ++ S +W + K + ++
Sbjct: 165 NITSGKLTVAGGAISKPLTDQTVAESQE---AVFECEVANPDSKGEWLRDGKHLPLTNNI 221
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDV 1033
+G D+G V +TS L V+ + + L++ V E
Sbjct: 222 RSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAV--KIKKTLKNLTVTETQD 279
Query: 1034 AILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
A+ VE+ + V W ++G +++ KY +G I L I+N ++ DE Y L
Sbjct: 280 AVFTVELTHPNVKGVQWIKNGVVLE-SNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLG 338
Query: 1093 DESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
+A + V + +II + ++ + FE+ ++ V+WF EI+ S+
Sbjct: 339 RLGASARLHVETV--KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKH 396
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANT 1212
+L + K KL + + DAGEY+ VG +C A L VE I T++ E VP
Sbjct: 397 RLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIE---VPETK 453
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
A E+ + W K IE +EKF ++ K LII + +D EYT V +
Sbjct: 454 TASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGN 513
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
+ + L V + + D E + +VT V+Y+ + +W+ N IK
Sbjct: 514 DQVSATLTVTPIMITSMLKDINAEEKDTITFEVT--VNYEGI---SYKWLKNGVEIKSTD 568
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ + SL I+ V DA Y A + + ++ +LE
Sbjct: 569 KCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDIKVLEK 628
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFR 1452
+ EP+ T + ++ + QE+ T+ I ++ K + T S +
Sbjct: 629 KRAMFECEVSEPDIT-----VQWMKDDQELQITDRIKIQK-EKYVHRLLIPSTRMSDAGK 682
Query: 1453 AYAVNEVDISDASETTEYYKV-IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQP 1511
V ++S A E V I+ K + +EK + E NED
Sbjct: 683 YTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNED-----------DV 731
Query: 1512 KVTWYRDGKKL-----KTAKATYENR-XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV 1565
WY+DG ++ + K E R Y +A + V + V
Sbjct: 732 DAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSV--TLYV 789
Query: 1566 GIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE 1625
+ P + + + + G AVI G P P++ WYK L +
Sbjct: 790 NAPEPPQVLQELQPVTVQS--GKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDG 847
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ + + E ++ YT EA N G ++ +L V
Sbjct: 848 QEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSV 884
Score = 135 bits (326), Expect = 2e-30
Identities = 180/799 (22%), Positives = 307/799 (38%), Gaps = 94/799 (11%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
KKPK E + + E + P + W K EI P + + E +H L +
Sbjct: 355 KKPKDVTALENATVAFEVSVSHDTVP-VKWFHKNVEIKPSDKHRLVSERKVHK----LML 409
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
N+ G YT V E +A L + E + + +K++ V + ++ +
Sbjct: 410 QNISPSDAGEYTAVVGQLECKAKLFV---------ETLHITKTMKNIEVPETKTASFECE 460
Query: 758 VVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V P++ W KN ++ G H + I+ +D YT N +
Sbjct: 461 VSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTS-TEDSAEYTFVCGNDQ--- 515
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
SA +TV P + + ++I +EK TI V + S W +N I
Sbjct: 516 -VSATLTVT--------PIMITSMLKDINAEEKDTITFEVTVNYEGI-SYKWLKNGVEIK 565
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL 934
++ L I NV D+ DY VA GK++ A + ++ + F KH+
Sbjct: 566 STDKCQMRTKKLTHSLNIRNVHFG-DAADYTFVA----GKATSTATLYVEARHIEFRKHI 620
Query: 935 QKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD 993
K + E K + EC+ S ++ +W + +E+ D +I +E D
Sbjct: 621 -KDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 679
Query: 994 VGVIKCIVKDQETSTMLVVKETIPEFIRKLQ-DFEVKEKDVAILEVEINSETADVVWERD 1052
G +V ST + E IR ++ + +V EK A++E E+N + D W +D
Sbjct: 680 AGKYT-VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 738
Query: 1053 GEIIK---PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL-RDESCTAEVTVVELPPE 1108
G I +++KY E+R H +++I T D GEY+ + R+ S PP+
Sbjct: 739 GIEINFQVQERHKYVVERRIH--RMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQ 796
Query: 1109 IITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
++ LQ V G A F ++ + + W+K+ + + DG++ L + +
Sbjct: 797 VLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIE 856
Query: 1168 CDLDDAGEYSCEVGN----SKCTAILTVEEPSI-NFTLRLPEF---ILVPANTD------ 1213
+DA Y+CE N + +A L+VE P + + +P + I+ P
Sbjct: 857 AFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQ 916
Query: 1214 -AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
A + L V+WY K I+ + F + L I + +D+ YT V +
Sbjct: 917 PARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASN 976
Query: 1273 A----KSTTKLKVE------------------VVEF-------PPKIVDYEREYRIKRGS 1303
A ST L +E V F P + R+ G
Sbjct: 977 AVGQVSSTANLSLEGFSKFEENTSNSQWHVSLSVSFKKEPLGQKPSFIQPLSSLRVHNGE 1036
Query: 1304 DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKS--ASLTIKKVENTDAGIYKLR 1361
V P+P +W N ++I K + + A + I + AG Y +
Sbjct: 1037 TVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEESTGMALMLIVDAYSEHAGQYSCK 1096
Query: 1362 LENNCGHADVEMNVTILDK 1380
N+ G A +T+ K
Sbjct: 1097 AANSAGEATCAATLTVTPK 1115
Score = 120 bits (289), Expect = 6e-26
Identities = 161/706 (22%), Positives = 286/706 (40%), Gaps = 58/706 (8%)
Query: 1018 EFIRKLQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYI 1076
+ I L+D V E A+LE +++ + V W + E IKP K G ++L I
Sbjct: 2 DVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVK-GTKQRLVI 60
Query: 1077 RNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL 1136
T DEG Y I+ ++V ++ +II L++ + FE+EL+
Sbjct: 61 NRTHASDEGPYKLIVGRVETNCNLSVEKI--KIIRGLRDLTCTETQNVVFEVELSHSGID 118
Query: 1137 VRW-FKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPS 1195
V W FKD EI+ S+ ++ GK KL + + DD G+Y+ G + + LTV +
Sbjct: 119 VLWNFKD-KEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAGGA 177
Query: 1196 INFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLII 1255
I+ L V + +A E+ + W + + T SD KR LII
Sbjct: 178 ISKPLTDQT---VAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLII 234
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFP 1315
DD EYT + +K++ KLKVE V KI + + D V+
Sbjct: 235 AATKLDDIGEYTYKVATSKTSAKLKVEAV----KIKKTLKNLTVTETQDAVFTVELTHPN 290
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMN- 1374
+WI N +++ + S+ SL IK D +Y RL A + +
Sbjct: 291 VKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET 350
Query: 1375 VTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNIT 1434
V I+ KP ++ ++++++ +T + VE + D +S + +
Sbjct: 351 VKIIKKPK-----DVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKHRLVSERKVH 405
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTE 1494
K +QN+ + + + A V +++ K+ ET + K +KNI
Sbjct: 406 KLM--LQNISPSDAGEYTA-VVGQLECKA--------KLFVETL----HITKTMKNIEVP 450
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXXXXXXXXXXXXXXX-YKC 1550
+ C P + W ++G +++ + K + + Y
Sbjct: 451 ETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTF 509
Query: 1551 IAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
+ ND T V I +IT +DI + K + VT EGI W KNG
Sbjct: 510 VCGNDQVSA-TLTVTPI----MITSMLKDINAEEKDTITFEVTVNYEGI---SYKWLKNG 561
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD------ 1664
++++ + + TK+ T + I+ + ++ YT A T+++ V + +
Sbjct: 562 VEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIK 621
Query: 1665 --KPSKPEGPVIMREISRESVTIEWKPPLDDGGLELT-KYAIEKHE 1707
K + + + E+S +T++W DD L++T + I+K +
Sbjct: 622 DIKVLEKKRAMFECEVSEPDITVQWMK--DDQELQITDRIKIQKEK 665
Score = 103 bits (246), Expect = 9e-21
Identities = 94/351 (26%), Positives = 150/351 (42%), Gaps = 57/351 (16%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +++L+P G +F + G P+P+I+W+++ ++ + +D TL+
Sbjct: 795 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEY-TLL 853
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP-LSDHGSEMTVXXXXXXXXXXXXADI 628
+ E FPEDA +TC AKN G A+++ L VE P + EM V
Sbjct: 854 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPV--------------- 898
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
PP + EG +CR V+ + ++W K ++I P + D
Sbjct: 899 ---YPPAIITPLQDTVTSEGQPARFQCR-VSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT 954
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK-------------------- 728
+ L+I EGTYT VA N G+ S L ++
Sbjct: 955 YQ----LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEGFSKFEENTSNSQWHVSLSV 1010
Query: 729 TGEKEP----PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK--- 781
+ +KEP P I+PL S+ V GE+V A+V G P+P I W N + + LPTK
Sbjct: 1011 SFKKEPLGQKPSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLI--LPTKDVV 1068
Query: 782 ---SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
+ ++ ++ + G Y+ KA NS G A +A +TV E+
Sbjct: 1069 FHFEESTGMALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTVTPKAPES 1119
Score = 99.5 bits (237), Expect = 1e-19
Identities = 77/287 (26%), Positives = 126/287 (43%), Gaps = 8/287 (2%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
++P P E P + L+ T +G +F+C+V G +++W+ + IKPS
Sbjct: 885 EVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPS 943
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTV 613
+ F+M +D L I E +PED GT+T VA NA G SST L +E S +
Sbjct: 944 RFFRMTQFEDTYQ-LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEG-FSKFEENTSN 1001
Query: 614 XXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEE 673
+ L G P+F + + V G + R+ IP+P+I W +
Sbjct: 1002 SQWHVSLSVSFKKEPL-GQKPSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQL 1060
Query: 674 IVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI--KTGE 731
I+P +++ E M +++ I + G Y+ A N GEA+ L + K E
Sbjct: 1061 ILPTKDVVFHFEESTGM--ALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTVTPKAPE 1118
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKAL 778
+ IE M +++ S LSA+ G + K N+ ++ L
Sbjct: 1119 SILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELL 1165
Score = 81.0 bits (191), Expect = 4e-14
Identities = 84/344 (24%), Positives = 146/344 (42%), Gaps = 42/344 (12%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP ++ + V G + P+P I+W +K E+++ D Y
Sbjct: 794 PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISW-YKEEQLL-STGFKCKFLHDGQEYT 851
Query: 693 SVLKITNVKKFQE--GTYTVVAVNREGEASLPIVLKIKTGE-----KE----PPQVIEPL 741
+L ++ F E YT A N G A+ L ++ E +E PP +I PL
Sbjct: 852 LLL----IEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 907
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKD 799
+ + +G+ +V G + K+ K P + DT+ + I + +D
Sbjct: 908 QDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYP-ED 966
Query: 800 EGVYTLKAENSEGIAETSAVITVE--EPTEENA---------------EP----PLFINR 838
EG YT A N+ G ++A +++E EEN EP P FI
Sbjct: 967 EGTYTFVASNAVGQVSSTANLSLEGFSKFEENTSNSQWHVSLSVSFKKEPLGQKPSFIQP 1026
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSE 898
+ V T++ ARV+ P P I W+ N ++I P++ + +F+ ++ VD+
Sbjct: 1027 LSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEESTGMALMLIVDAY 1086
Query: 899 ID-SGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE 941
+ +G Y C A+NSAG+++ A +T+ + + H + E E
Sbjct: 1087 SEHAGQYSCKAANSAGEATCAATLTVTPKAPESILHERIEQEIE 1130
Score = 74.5 bits (175), Expect = 4e-12
Identities = 123/584 (21%), Positives = 226/584 (38%), Gaps = 62/584 (10%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
+K K V E EC + P + WL G EI E + ++ +H L
Sbjct: 441 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ----LI 495
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
I N YT V N + A+L + P + LK + + +++
Sbjct: 496 IMNTSTEDSAEYTFVCGNDQVSATLTVT---------PIMITSMLKDINAEEKDTITFEV 546
Query: 757 QVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
V + W KN +K+ ++ THS+ I + D YT A G
Sbjct: 547 -TVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNI-RNVHFGDAADYTFVA----GK 600
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A ++A + VE E F ++I V EK V+ P ++ W ++++ +
Sbjct: 601 ATSTATLYVEARHIE------FRKHIKDIKVLEKKRAMFECEVSE-PDITVQWMKDDQEL 653
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ I + L+I + D+G Y VA + A++ ++ V ++
Sbjct: 654 QITDRIKIQKEKYVHRLLIPSTRMS-DAGKYTVVAGGNVST----AKLFVEGRDVR-IRS 707
Query: 934 LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGM--DHREIIQEGRXXXXXXXXXX 990
++K + E + ++E + + V WY + EI+ + + + E R
Sbjct: 708 IKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETR 767
Query: 991 XXDVGVIKCIV-KDQETSTMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVV 1048
D G + +++ + T+ V P+ +++LQ V+ K V +
Sbjct: 768 QSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKIS 827
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE------SCTAEVTV 1102
W ++ +++ K F G L + D Y+C +++ S + V V
Sbjct: 828 WYKEEQLLSTGF-KCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEV 886
Query: 1103 VEL----------PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
E+ PP IIT LQ+ ++G A F+ ++ D V W+ +I+ S
Sbjct: 887 PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFF 946
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEY----SCEVGNSKCTAILTVE 1192
++T +L+I + +D G Y S VG TA L++E
Sbjct: 947 RMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLE 990
Score = 73.7 bits (173), Expect = 6e-12
Identities = 77/300 (25%), Positives = 115/300 (38%), Gaps = 30/300 (10%)
Query: 670 KGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE--ASLPIVLKI 727
K E + E I IE +M + S + + +N E + P+
Sbjct: 1115 KAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYSTK 1174
Query: 728 KTGEKEP--PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN---KPVKALPTKS 782
EKE P I+ + + + G+ LS V+G P+P I W N P
Sbjct: 1175 FDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVF 1234
Query: 783 DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE----------- 831
DGD HS+ IL K++DEG YT A N G SA + + E + +
Sbjct: 1235 DGDDHSLIILF-TKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSL 1293
Query: 832 -------PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS--ETITQN 882
PP F+ + I + V P P++TW++ N+ + S TI N
Sbjct: 1294 EKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHN 1353
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
+G I N DSG Y C A N G+S+ A + + +E K+ T E
Sbjct: 1354 PNGSG--TFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAKSTPE 1411
Score = 73.3 bits (172), Expect = 9e-12
Identities = 54/205 (26%), Positives = 92/205 (44%), Gaps = 13/205 (6%)
Query: 476 DENNYTQYLQ-KKLNEKIDKL---PVFE-KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFE 530
+E ++ LQ K+NE ++ L PV+ K SE++ PIF++++ G
Sbjct: 1145 EEGLHSAELQLSKINETLELLSESPVYSTKFDSEKEGTGPIFIKEVSNADISMGDVATLS 1204
Query: 531 CQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
V G P+P+I WF ++ PS D++ +D D+ +L+I ED G +TC+A N G
Sbjct: 1205 VTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDD-HSLIILFTKLEDEGEYTCMASNDYG 1263
Query: 591 FASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEG-IPPTFSKKPKAQYVDEGS 649
+ L + + H T + L G PP F K+ K +G
Sbjct: 1264 KTICSAYLKINSKGEGHKDTET------ESAVAKSLEKLGGPCPPHFLKELKPIRCAQGL 1317
Query: 650 DILLECRLVAIPEPDIAWLFKGEEI 674
+ E +V P P + W + +++
Sbjct: 1318 PAIFEYTVVGEPAPTVTWFKENKQL 1342
Score = 72.9 bits (171), Expect = 1e-11
Identities = 64/217 (29%), Positives = 88/217 (40%), Gaps = 28/217 (12%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
EG P F K+ + G L ++ IP+P I W F G + P + + D H
Sbjct: 1180 EGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDH 1239
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT---GEKE------------- 733
L I K EG YT +A N G+ LKI + G K+
Sbjct: 1240 S----LIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEK 1295
Query: 734 -----PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV--KALPTKSDGDT 786
PP ++ LK + QG I VVG P PT+TW K NK + T
Sbjct: 1296 LGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPN 1355
Query: 787 HSIT-ILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
S T I+ + +D G+Y KAEN G + +A + V
Sbjct: 1356 GSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 1392
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/191 (29%), Positives = 87/191 (45%), Gaps = 13/191 (6%)
Query: 1012 VKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHI 1071
+KE P L D +E D+ L I + +V W + +++ P K+ + +
Sbjct: 1965 IKEDGPMIHTPLVDTVSEEGDIVHLTTSITN-AKEVNWYFENKLV-PSDEKFKCLQDQNT 2022
Query: 1072 RKLYIRNTSVHD-EGEYSC-ILRDESCTA---EVTVVELPPEIITR-LQNQKVNKGNKAT 1125
L I + D +GEY C L D TA ++TVV+ +I R ++ +V G+ A
Sbjct: 2023 YTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAK 2082
Query: 1126 FEIELTKG-DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EV 1180
F E+ + +WFK G EI S+ + L+I + D GEY+C E
Sbjct: 2083 FTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEY 2142
Query: 1181 GNSKCTAILTV 1191
G+ CTA LTV
Sbjct: 2143 GSVSCTATLTV 2153
Score = 57.2 bits (132), Expect = 6e-07
Identities = 26/91 (28%), Positives = 48/91 (52%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++L+P G FE V G P P +TWF++ + S + + ++ + T +
Sbjct: 1302 PHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTIIHNPNGSGTFI 1361
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ + ED+G + C A+N G ++ EL+V
Sbjct: 1362 VNDPQREDSGLYICKAENMLGESTCAAELLV 1392
Score = 57.2 bits (132), Expect = 6e-07
Identities = 42/167 (25%), Positives = 69/167 (41%), Gaps = 5/167 (2%)
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKC-TEDDQCEYTCVLLD- 1272
+LT I + +V WY + ++ EKF + D TL+I K TED Q EY C L+
Sbjct: 1988 HLTTSITNAK-EVNWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALND 2046
Query: 1273 -AKSTTKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
K+ T K+ VV+ ++ + E + G + Q+ P +W + I +
Sbjct: 2047 SGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE 2106
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+SL I + + D G Y + N G +T+
Sbjct: 2107 SDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 2153
Score = 55.6 bits (128), Expect = 2e-06
Identities = 49/229 (21%), Positives = 84/229 (36%), Gaps = 13/229 (5%)
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE--NAEPPLFINRFQEITVKEKGT 849
LKP + K+E +SE E A + ++E + P+ + +E
Sbjct: 1934 LKPSEEKEES-------SSESGTEEVATVKIQEAEGGFIKEDGPMIHTPLVDTVSEEGDI 1986
Query: 850 IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS 909
+ L +T + WY N+++ E D LVI V++E G+Y C A
Sbjct: 1987 VHLTTSITN--AKEVNWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEAL 2044
Query: 910 NSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSHTVSTKWYHNKKEI 967
N +GK++ A++T+ +K + E G C Q++ V +W+ +EI
Sbjct: 2045 NDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREI 2104
Query: 968 SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI 1016
D I D G C ++ S T+
Sbjct: 2105 YESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 2153
Score = 52.4 bits (120), Expect = 2e-05
Identities = 59/267 (22%), Positives = 105/267 (39%), Gaps = 37/267 (13%)
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
Y V S + E E +E + P + PL++ T + C G KV
Sbjct: 873 YGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KV 931
Query: 1514 TWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ- 1568
+WY KK+K ++ +E+ Y +A N G+V ++ + ++
Sbjct: 932 SWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEG 991
Query: 1569 -----------QKPV---ITISNEDIKQKHKV-----------GDEWLVTAVIEGIPPPE 1603
Q V ++ E + QK G+ A + GIP PE
Sbjct: 992 FSKFEENTSNSQWHVSLSVSFKKEPLGQKPSFIQPLSSLRVHNGETVRFHARVSGIPKPE 1051
Query: 1604 VIWYKNGNKLENDKEYNITTKEKT--SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
+ W+ N + K+ +E T +++ I + H+ +Y+ +A+N+AG ++ TL
Sbjct: 1052 IQWFHNQQLILPTKDVVFHFEESTGMALMLIVDAYSEHAGQYSCKAANSAGEATCAATLT 1111
Query: 1662 VYDKPSKPEGPVIMREISRESVTIEWK 1688
V P PE I+ E + + +E K
Sbjct: 1112 V--TPKAPES--ILHERIEQEIEMEMK 1134
Score = 52.0 bits (119), Expect = 2e-05
Identities = 46/198 (23%), Positives = 83/198 (41%), Gaps = 15/198 (7%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTH 787
+++ P + PL + +G+ V L+ + + W NK V + D +T+
Sbjct: 1966 KEDGPMIHTPLVDTVSEEGDIVHLTTSITNAKE--VNWYFENKLVPSDEKFKCLQDQNTY 2023
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
++ I K +G Y +A N G TSA +TV + P+ + + + V
Sbjct: 2024 TLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVK-----RAAPVIKRKIEPLEVALG 2078
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSE--TITQNFDGENIELVITNVDSEIDSGDYK 905
K + P W++ I S+ +I + ++E++ T V +D G+Y
Sbjct: 2079 HLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQV---VDCGEYT 2135
Query: 906 CVASNSAGKSSHGARVTI 923
C ASN G S A +T+
Sbjct: 2136 CKASNEYGSVSCTATLTV 2153
Score = 47.6 bits (108), Expect = 5e-04
Identities = 41/190 (21%), Positives = 72/190 (37%), Gaps = 7/190 (3%)
Query: 1478 KIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXX 1534
K P + PL + +E + + LT + V WY + K + + K +
Sbjct: 1966 KEDGPMIHTPLVDTVSEEGDIVHLTTSITNAKE--VNWYFENKLVPSDEKFKCLQDQNTY 2023
Query: 1535 XXXXXXXXXXXXX--YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLV 1592
Y C A ND G+ TS + + ++ I + + +G
Sbjct: 2024 TLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKF 2083
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
T I+ P W+K G ++ + +I + + S + I + +YT +ASN G
Sbjct: 2084 TCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYG 2143
Query: 1653 TSSVEVTLKV 1662
+ S TL V
Sbjct: 2144 SVSCTATLTV 2153
Score = 46.8 bits (106), Expect = 9e-04
Identities = 33/124 (26%), Positives = 54/124 (43%), Gaps = 3/124 (2%)
Query: 477 ENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGY 536
E++ +Y+ + LN+ K K T +++ AP+ K+ P G +F C+++
Sbjct: 2033 EDHQGEYVCEALNDS-GKTATSAKLTVVKRA-APVIKRKIEPLEVALGHLAKFTCEIQSA 2090
Query: 537 PRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTT 596
P + WF+ I S D +++L I D G +TC A N G S T
Sbjct: 2091 PNVRFQWFKAGREIYES-DKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTA 2149
Query: 597 ELIV 600
L V
Sbjct: 2150 TLTV 2153
Score = 46.4 bits (105), Expect = 0.001
Identities = 46/174 (26%), Positives = 67/174 (38%), Gaps = 12/174 (6%)
Query: 940 TEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD-VGVIK 998
+EEG V L ++ WY K + + + +Q+ D G
Sbjct: 1981 SEEGDIVHLTTSITNAKEVNWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYV 2040
Query: 999 CIV-----KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERD 1052
C K ++ + VVK P RK++ EV +A EI S W +
Sbjct: 2041 CEALNDSGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKA 2100
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE----SCTAEVTV 1102
G I + +K +I L I T V D GEY+C +E SCTA +TV
Sbjct: 2101 GREIY-ESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 2153
Score = 41.1 bits (92), Expect = 0.042
Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 2/81 (2%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P FI+++ + ++ DVA L V I + W +G ++ P + Y F G
Sbjct: 1182 TGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSAD-YKFVFDGDDHS 1240
Query: 1074 LYIRNTSVHDEGEYSCILRDE 1094
L I T + DEGEY+C+ ++
Sbjct: 1241 LIILFTKLEDEGEYTCMASND 1261
Score = 40.7 bits (91), Expect = 0.056
Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 4/91 (4%)
Query: 1575 ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKE 1634
+SN DI +GD ++ + GIP P++ W+ NG L +Y + I
Sbjct: 1190 VSNADIS----MGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILF 1245
Query: 1635 LKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
K +YT ASN G + LK+ K
Sbjct: 1246 TKLEDEGEYTCMASNDYGKTICSAYLKINSK 1276
Score = 38.3 bits (85), Expect = 0.30
Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 5/90 (5%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P I + N ++ G+ AT + + ++WF +G + S + DG L I
Sbjct: 1184 PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLII 1243
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTV 1191
L+D GEY+C + G + C+A L +
Sbjct: 1244 LFTKLEDEGEYTCMASNDYGKTICSAYLKI 1273
Score = 37.5 bits (83), Expect = 0.52
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 9/109 (8%)
Query: 509 APIFVEKLRPKHT------PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
A +FVE L T P+ T FEC+V + P + W + I+ S+ F++
Sbjct: 431 AKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVV-Q 488
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASST-TELIVEAPLSDHGSE 610
+ L+I ED+ +T V N A+ T T +++ + L D +E
Sbjct: 489 GKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLKDINAE 537
Score = 36.7 bits (81), Expect = 0.91
Identities = 41/183 (22%), Positives = 70/183 (38%), Gaps = 16/183 (8%)
Query: 1475 KETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT---YEN 1531
KE Q P+ +PL ++ E + G+P+P++ W+ + + + K +E
Sbjct: 1014 KEPLGQKPSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEE 1073
Query: 1532 RXXXX---XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQ----KH 1584
Y C A N GE + + + K +I +E I+Q +
Sbjct: 1074 STGMALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTVTPKAPESILHERIEQEIEMEM 1133
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI------TTKEKTSVIRIKELKRS 1638
K ++A EG+ E+ K LE E + + KE T I IKE+ +
Sbjct: 1134 KEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYSTKFDSEKEGTGPIFIKEVSNA 1193
Query: 1639 HSS 1641
S
Sbjct: 1194 DIS 1196
>AJ277892-4|CAD12458.1| 1294|Homo sapiens Titin Novex-2 Isoform
protein.
Length = 1294
Score = 179 bits (436), Expect = 9e-44
Identities = 174/747 (23%), Positives = 309/747 (41%), Gaps = 47/747 (6%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
SK Q V E + + EC VA P+ WL G+ + NI ESD H ++
Sbjct: 179 SKPLTDQTVAESQEAVFECE-VANPDSKGEWLRDGKHLPLTNNIRS--ESDGHKRRLIIA 235
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
T + E TY V + + V KIK + LK++ V + + + +
Sbjct: 236 ATKLDDIGEYTYKVATSKTSAKLKVEAV-KIK----------KTLKNLTVTETQDAVFTV 284
Query: 757 QVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
++ + W KN +++ G +S+ I K + DE VY + G
Sbjct: 285 ELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRI-KNCAIVDESVYGFRL----GR 339
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
SA + VE I + +++T E T+ V+ + VP + W+ N I
Sbjct: 340 LGASARLHVETVK--------IIKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKNVEI 390
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
PS+ + + +L++ N+ S D+G+Y V G+ A++ ++ +T
Sbjct: 391 KPSDKHRLVSERKVHKLMLQNI-SPSDAGEYTAVV----GQLECKAKLFVETLHIT---K 442
Query: 934 LQKSYETEEGKTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXX 992
K+ E E KT EC+ SH V + W N EI + +I+ +G+
Sbjct: 443 TMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE 502
Query: 993 DVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERD 1052
D + + + S L V + L+D +EKD EV +N E W ++
Sbjct: 503 DSAEYTFVCGNDQVSATLTVTPIM--ITSMLKDINAEEKDTITFEVTVNYEGISYKWLKN 560
Query: 1053 GEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR 1112
G IK +K + L IRN D +Y+ + + TA + V E
Sbjct: 561 GVEIK-STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKH 619
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+++ KV + +A FE E+++ D V+W KD E+Q ++ I++ + +L I + D
Sbjct: 620 IKDIKVLEKKRAMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSD 679
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK 1232
AG+Y+ G + TA L VE + + + + V A + E+ ++ +D WYK
Sbjct: 680 AGKYTVVAGGNVSTAKLFVEGRDVRIR-SIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKD 738
Query: 1233 KSVI--EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKI 1290
I + E+ + + + + I + + D EYT V +S+ L V E PP++
Sbjct: 739 GIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPE-PPQV 797
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
+ + ++ G PQP W +++ K D + +L + +
Sbjct: 798 LQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEA 857
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTI 1377
DA +Y +N+ G A ++++
Sbjct: 858 FPEDAAVYTCEAKNDYGVATTSASLSV 884
Score = 178 bits (434), Expect = 2e-43
Identities = 241/1064 (22%), Positives = 411/1064 (38%), Gaps = 88/1064 (8%)
Query: 645 VDEGSDILLECRLVAIPE-PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG+ +LEC+ V++P+ + W E+I PD+ + ++ L I
Sbjct: 12 VIEGTKAVLECK-VSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQR----LVINRTHAS 66
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
EG Y ++ E +L V KIK +I L+ + + ++V+ + + +
Sbjct: 67 DEGPYKLIVGRVETNCNLS-VEKIK--------IIRGLRDLTCTETQNVVFEVE-LSHSG 116
Query: 764 PTITW---CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+ W K KP ++ G + +T+L K DEG YT A E I TS +
Sbjct: 117 IDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMK-DDEGKYTFYA--GENI--TSGKL 171
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
TV PL + TV E V NP W R+ + + + I
Sbjct: 172 TVAGGA---ISKPL-----TDQTVAESQEAVFECEVA-NPDSKGEWLRDGKHLPLTNNIR 222
Query: 881 QNFDGENIELVI--TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
DG L+I T +D +I YK S ++ K + VE V K L+
Sbjct: 223 SESDGHKRRLIIAATKLD-DIGEYTYKVATSKTSAK--------LKVEAVKIKKTLKNLT 273
Query: 939 ETEEGKTVI-LECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVI 997
TE V +E + +W N + + I +G D V
Sbjct: 274 VTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVY 333
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIK 1057
+ S L V ET+ + I+K +D E EV ++ +T V W IK
Sbjct: 334 GFRLGRLGASARLHV-ETV-KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIK 391
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQK 1117
P +K+ + KL ++N S D GEY+ ++ C A++ V L I ++N +
Sbjct: 392 P-SDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETL--HITKTMKNIE 448
Query: 1118 VNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
V + A+FE E++ + W K+G EI+ S ++ + GK +L I + +D+ EY+
Sbjct: 449 VPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT 508
Query: 1178 CEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE 1237
GN + +A LTV I T L + +T + V + E + W K I+
Sbjct: 509 FVCGNDQVSATLTV--TPIMITSMLKDINAEEKDTITF-EVTVNYEGISYKWLKNGVEIK 565
Query: 1238 DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV--VEFPPKIVDYER 1295
T+K + + +L IR D +YT V A ST L VE +EF I D +
Sbjct: 566 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDI-K 624
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDA 1355
KR + + P +W+ + + ++ K + L I +DA
Sbjct: 625 VLEKKR----AMFECEVSEPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDA 680
Query: 1356 GIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
G Y + N A + + + S + ++E + + +E + +
Sbjct: 681 GKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGI 740
Query: 1416 VVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIK 1475
+ +Q + +++ + I + S Y F V + S T Y
Sbjct: 741 EINFQVQERHKYVVERRIHRMFISETRQSDAGEYTF-------VAGRNRSSVTLYVNA-- 791
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENR 1532
+ P V + L+ +T + + + G PQPK++WY++ + L T K ++ +
Sbjct: 792 ---PEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQ 848
Query: 1533 XXXXXXXXXX-XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A ND+G TS + ++ V++ E +
Sbjct: 849 EYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQ 908
Query: 1592 VTAVIEGIPPP----------EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
T EG P +V WY K++ + + +T E T + I E
Sbjct: 909 DTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEG 968
Query: 1642 KYTIEASNTAG--TSSVEVTLKVYDKPSKPEGPVIMREISRESV 1683
YT ASN G +S+ ++L+V + G + ++V
Sbjct: 969 TYTFVASNAVGQVSSTANLSLEVQALDRQSSGKDVRESTKSQAV 1012
Score = 165 bits (401), Expect = 2e-39
Identities = 206/926 (22%), Positives = 373/926 (40%), Gaps = 83/926 (8%)
Query: 793 KPKKVKDEGVYTLKAEN--SEGIAETSAVITVEEPTEENAEPPLFINR-FQEITVKEKGT 849
K + V + V+ L +N E +AV+ E + L I + + I V E T
Sbjct: 395 KHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKT 454
Query: 850 IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS 909
V+ VPS+ W +N I SE G+ +L+I N +E DS +Y V
Sbjct: 455 ASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE-DSAEYTFVCG 512
Query: 910 NSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEIS 968
N T+ V + L K EE T+ E ++ +S KW N EI
Sbjct: 513 NDQ------VSATLTVTPIMITSML-KDINAEEKDTITFEVTVNYEGISYKWLKNGVEIK 565
Query: 969 GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEV 1028
D ++ + D + ++ L V+ EF + ++D +V
Sbjct: 566 STDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDIKV 625
Query: 1029 KEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
EK A+ E E++ V W +D + ++ ++ +K ++ +L I +T + D G+Y+
Sbjct: 626 LEKKRAMFECEVSEPDITVQWMKDDQELQIT-DRIKIQKEKYVHRLLIPSTRMSDAGKYT 684
Query: 1089 CILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQF 1148
+ TA++ V I + + +V + +A E E+ + D W+KDG EI F
Sbjct: 685 VVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINF 744
Query: 1149 S--NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFI 1206
+ ++ + ++ I + DAGEY+ G ++ + L V P L+ + +
Sbjct: 745 QVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPV 804
Query: 1207 LVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCE 1265
V + A I ++WYK++ ++ K + D ++ TL++ + +D
Sbjct: 805 TVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAV 864
Query: 1266 YTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD----------Y 1311
YTC + A ++ L VEV P++V ++E + + +T L D +
Sbjct: 865 YTCEAKNDYGVATTSASLSVEV----PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARF 920
Query: 1312 QAFPQPND---EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
Q D W K IK + + + + L I + D G Y N G
Sbjct: 921 QCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQ 980
Query: 1369 ----ADVEMNVTILDKPSPPGKPNILEIDSSSI---NICWDEPENTGNSTIIYYVVEYQ- 1420
A++ + V LD+ S GK S ++ + +E + + + Y+
Sbjct: 981 VSSTANLSLEVQALDRQSS-GKDVRESTKSQAVADSSFTKEESKISQKEIKSFQGSSYEY 1039
Query: 1421 EIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK-VIKETKI 1479
E+ E +S +I T S+Q+ + + +S +E+TE K KE+
Sbjct: 1040 EVQVFESVSQSSI-HTAASVQDTQL----------CHTASLSQIAESTELSKECAKESTG 1088
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXX 1539
++P + L+++T + + + C+ VTW +G K++ ++ +++
Sbjct: 1089 EAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEESERLKQSQNGNIQFL 1148
Query: 1540 XX----XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQ------------K 1583
Y CI ND GE TS V+ ++ P +I +E I+Q K
Sbjct: 1149 TICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEGAPE-SILHERIEQEIEMEMKAAPVIK 1207
Query: 1584 HKV-------GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELK 1636
K+ G T I+ P W+K G ++ + +I + + S + I +
Sbjct: 1208 RKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQ 1267
Query: 1637 RSHSSKYTIEASNTAGTSSVEVTLKV 1662
+YT +ASN G+ S TL V
Sbjct: 1268 VVDCGEYTCKASNEYGSVSCTATLTV 1293
Score = 159 bits (387), Expect = 8e-38
Identities = 127/426 (29%), Positives = 190/426 (44%), Gaps = 16/426 (3%)
Query: 936 KSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD 993
K EG +LEC+ S S KWY N ++I D + I +G D
Sbjct: 8 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASD 67
Query: 994 VGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDG 1053
G K IV ET+ L V++ + IR L+D E + EVE++ DV+W
Sbjct: 68 EGPYKLIVGRVETNCNLSVEKI--KIIRGLRDLTCTETQNVVFEVELSHSGIDVLWNFKD 125
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRL 1113
+ IKP +KY E G I KL + N DEG+Y+ + + ++TV I L
Sbjct: 126 KEIKPS-SKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAG--GAISKPL 182
Query: 1114 QNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDA 1173
+Q V + +A FE E+ D+ W +DG + +N+I+ DG K++L I LDD
Sbjct: 183 TDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDDI 242
Query: 1174 GEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTWYKK 1232
GEY+ +V SK +A L VE I TL+ + V DA TVE+ + V W K
Sbjct: 243 GEYTYKVATSKTSAKLKVEAVKIKKTLK---NLTVTETQDAVFTVELTHPNVKGVQWIKN 299
Query: 1233 KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
V+E EK+ + +L I+ C D+ Y L ++ +L VE V KI+
Sbjct: 300 GVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVETV----KIIK 355
Query: 1293 YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
++ + V V P + N +I KH S + K L ++ +
Sbjct: 356 KPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKHRLVS-ERKVHKLMLQNISP 414
Query: 1353 TDAGIY 1358
+DAG Y
Sbjct: 415 SDAGEY 420
Score = 149 bits (362), Expect = 8e-35
Identities = 131/544 (24%), Positives = 222/544 (40%), Gaps = 27/544 (4%)
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV 895
I +++ V E L +V+ V S+ WY N+E I P + + G LVI
Sbjct: 4 ITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRT 63
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT 955
+ D G YK + + VEK+ ++ L + E + V+ E + SH+
Sbjct: 64 HAS-DEGPYKLIVGRVE------TNCNLSVEKIKIIRGL-RDLTCTETQNVVFEVELSHS 115
Query: 956 -VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKE 1014
+ W KEI +I G+ D G + TS L V
Sbjct: 116 GIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAG 175
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKL 1074
+ L D V E A+ E E+ + + W RDG+ + P N E GH R+L
Sbjct: 176 --GAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHL-PLTNNIRSESDGHKRRL 232
Query: 1075 YIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGD 1134
I T + D GEY+ + +A++ V + +I L+N V + A F +ELT +
Sbjct: 233 IIAATKLDDIGEYTYKVATSKTSAKLKVEAV--KIKKTLKNLTVTETQDAVFTVELTHPN 290
Query: 1135 AL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
V+W K+G ++ + +++ G L+I +C + D Y +G +A L VE
Sbjct: 291 VKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET 350
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
I ++ P+ + N V + +T+ V W+ K I+ ++K L+S+ K L
Sbjct: 351 VKI---IKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKHRLVSERKVHKL 407
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQA 1313
+++ + D EYT V+ + KL VE + + + E + + +
Sbjct: 408 MLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIE----VPETKTASFECEVSH 463
Query: 1314 FPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
F P+ W+ N I+ + K + K L I D+ Y CG+ V
Sbjct: 464 FNVPS-MWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTF----VCGNDQVSA 518
Query: 1374 NVTI 1377
+T+
Sbjct: 519 TLTV 522
Score = 147 bits (355), Expect = 6e-34
Identities = 203/937 (21%), Positives = 363/937 (38%), Gaps = 66/937 (7%)
Query: 737 VIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD--GDTHSITILKP 794
VI PLK + V +G +L +V ++ W N++ +K T ++
Sbjct: 3 VITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINR 62
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
DEG Y L G ET+ ++VE+ I +++T E +
Sbjct: 63 THASDEGPYKLIV----GRVETNCNLSVEKIK--------IIRGLRDLTCTETQNVVFEV 110
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
++ + + + W ++ I PS G+ +L + N+ + D G Y + AG+
Sbjct: 111 ELSHSGI-DVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKD-DEGKY----TFYAGE 164
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVST-KWYHNKKEISGMDHR 973
+ ++T+ ++ Q E++E + EC+ ++ S +W + K + ++
Sbjct: 165 NITSGKLTVAGGAISKPLTDQTVAESQE---AVFECEVANPDSKGEWLRDGKHLPLTNNI 221
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDV 1033
+G D+G V +TS L V+ + + L++ V E
Sbjct: 222 RSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKVEAV--KIKKTLKNLTVTETQD 279
Query: 1034 AILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
A+ VE+ + V W ++G +++ KY +G I L I+N ++ DE Y L
Sbjct: 280 AVFTVELTHPNVKGVQWIKNGVVLE-SNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLG 338
Query: 1093 DESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
+A + V + +II + ++ + FE+ ++ V+WF EI+ S+
Sbjct: 339 RLGASARLHVETV--KIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKH 396
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANT 1212
+L + K KL + + DAGEY+ VG +C A L VE I T++ E VP
Sbjct: 397 RLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIE---VPETK 453
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
A E+ + W K IE +EKF ++ K LII + +D EYT V +
Sbjct: 454 TASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGN 513
Query: 1273 AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
+ + L V + + D E + +VT V+Y+ + +W+ N IK
Sbjct: 514 DQVSATLTVTPIMITSMLKDINAEEKDTITFEVT--VNYEGI---SYKWLKNGVEIKSTD 568
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ + SL I+ V DA Y A + + ++ +LE
Sbjct: 569 KCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKDIKVLEK 628
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFR 1452
+ EP+ T + ++ + QE+ T+ I ++ K + T S +
Sbjct: 629 KRAMFECEVSEPDIT-----VQWMKDDQELQITDRIKIQK-EKYVHRLLIPSTRMSDAGK 682
Query: 1453 AYAVNEVDISDASETTEYYKV-IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQP 1511
V ++S A E V I+ K + +EK + E NED
Sbjct: 683 YTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNED-----------DV 731
Query: 1512 KVTWYRDGKKL-----KTAKATYENR-XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV 1565
WY+DG ++ + K E R Y +A + V + V
Sbjct: 732 DAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSV--TLYV 789
Query: 1566 GIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE 1625
+ P + + + + G AVI G P P++ WYK L +
Sbjct: 790 NAPEPPQVLQELQPVTVQS--GKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDG 847
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ + + E ++ YT EA N G ++ +L V
Sbjct: 848 QEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSV 884
Score = 120 bits (289), Expect = 6e-26
Identities = 161/706 (22%), Positives = 286/706 (40%), Gaps = 58/706 (8%)
Query: 1018 EFIRKLQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYI 1076
+ I L+D V E A+LE +++ + V W + E IKP K G ++L I
Sbjct: 2 DVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVK-GTKQRLVI 60
Query: 1077 RNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL 1136
T DEG Y I+ ++V ++ +II L++ + FE+EL+
Sbjct: 61 NRTHASDEGPYKLIVGRVETNCNLSVEKI--KIIRGLRDLTCTETQNVVFEVELSHSGID 118
Query: 1137 VRW-FKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPS 1195
V W FKD EI+ S+ ++ GK KL + + DD G+Y+ G + + LTV +
Sbjct: 119 VLWNFKD-KEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENITSGKLTVAGGA 177
Query: 1196 INFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLII 1255
I+ L V + +A E+ + W + + T SD KR LII
Sbjct: 178 ISKPLTDQT---VAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLII 234
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFP 1315
DD EYT + +K++ KLKVE V KI + + D V+
Sbjct: 235 AATKLDDIGEYTYKVATSKTSAKLKVEAV----KIKKTLKNLTVTETQDAVFTVELTHPN 290
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMN- 1374
+WI N +++ + S+ SL IK D +Y RL A + +
Sbjct: 291 VKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVET 350
Query: 1375 VTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNIT 1434
V I+ KP ++ ++++++ +T + VE + D +S + +
Sbjct: 351 VKIIKKPK-----DVTALENATVAFEVSVSHDTVPVKWFHKNVEIKPSDKHRLVSERKVH 405
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTE 1494
K +QN+ + + + A V +++ K+ ET + K +KNI
Sbjct: 406 KLM--LQNISPSDAGEYTA-VVGQLECKA--------KLFVETL----HITKTMKNIEVP 450
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXXXXXXXXXXXXXXX-YKC 1550
+ C P + W ++G +++ + K + + Y
Sbjct: 451 ETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTF 509
Query: 1551 IAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
+ ND T V I +IT +DI + K + VT EGI W KNG
Sbjct: 510 VCGNDQVSA-TLTVTPI----MITSMLKDINAEEKDTITFEVTVNYEGI---SYKWLKNG 561
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD------ 1664
++++ + + TK+ T + I+ + ++ YT A T+++ V + +
Sbjct: 562 VEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIK 621
Query: 1665 --KPSKPEGPVIMREISRESVTIEWKPPLDDGGLELT-KYAIEKHE 1707
K + + + E+S +T++W DD L++T + I+K +
Sbjct: 622 DIKVLEKKRAMFECEVSEPDITVQWMK--DDQELQITDRIKIQKEK 665
Score = 105 bits (252), Expect = 2e-21
Identities = 96/420 (22%), Positives = 170/420 (40%), Gaps = 38/420 (9%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +++L+P G +F + G P+P+I+W+++ ++ + +D TL+
Sbjct: 795 PQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEY-TLL 853
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP-LSDHGSEMTVXXXXXXXXXXXXADI 628
+ E FPEDA +TC AKN G A+++ L VE P + EM V
Sbjct: 854 LIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPV--------------- 898
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
PP + EG +CR V+ + ++W K ++I P + D
Sbjct: 899 ---YPPAIITPLQDTVTSEGQPARFQCR-VSGTDLKVSWYSKDKKIKPSRFFRMTQFEDT 954
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGE----ASLPIVLKIKTGEKEPPQVIEPLKSM 744
+ L+I EGTYT VA N G+ A+L + ++ + V E KS
Sbjct: 955 YQ----LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEVQALDRQSSGKDVRESTKSQ 1010
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYT 804
V +++ + V+ + S H+ ++ ++ +
Sbjct: 1011 AVADSSFTKEESKISQKEIKSFQGSSYEYEVQVFESVSQSSIHTAASVQDTQLCHTASLS 1070
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
AE++E ++ E E E P Q++TVK T + + + + +
Sbjct: 1071 QIAESTE--------LSKECAKESTGEAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDV 1122
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
TW I SE + Q+ +G L I NV +D G Y C+ N G+ + A ++++
Sbjct: 1123 TWTHEGAKIEESERLKQSQNGNIQFLTICNVQL-VDQGLYSCIVHNDCGERTTSAVLSVE 1181
Score = 90.6 bits (215), Expect = 5e-17
Identities = 156/779 (20%), Positives = 297/779 (38%), Gaps = 69/779 (8%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
+K K V E EC + P + WL G EI E + ++ +H L
Sbjct: 441 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQ----LI 495
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSA 756
I N YT V N + A+L + P + LK + + +++
Sbjct: 496 IMNTSTEDSAEYTFVCGNDQVSATLTVT---------PIMITSMLKDINAEEKDTITFEV 546
Query: 757 QVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
V + W KN +K+ ++ THS+ I + D YT A G
Sbjct: 547 -TVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNI-RNVHFGDAADYTFVA----GK 600
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A ++A + VE E F ++I V EK V+ P ++ W ++++ +
Sbjct: 601 ATSTATLYVEARHIE------FRKHIKDIKVLEKKRAMFECEVSE-PDITVQWMKDDQEL 653
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ I + L+I + D+G Y VA + A++ ++ V ++
Sbjct: 654 QITDRIKIQKEKYVHRLLIPSTRMS-DAGKYTVVAGGNVST----AKLFVEGRDVR-IRS 707
Query: 934 LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGM--DHREIIQEGRXXXXXXXXXX 990
++K + E + ++E + + V WY + EI+ + + + E R
Sbjct: 708 IKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETR 767
Query: 991 XXDVGVIKCIV-KDQETSTMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVV 1048
D G + +++ + T+ V P+ +++LQ V+ K V +
Sbjct: 768 QSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKIS 827
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE------SCTAEVTV 1102
W ++ +++ K F G L + D Y+C +++ S + V V
Sbjct: 828 WYKEEQLLSTGF-KCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEV 886
Query: 1103 VEL----------PPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
E+ PP IIT LQ+ ++G A F+ ++ D V W+ +I+ S
Sbjct: 887 PEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFF 946
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEY----SCEVGNSKCTAILTVEEPSINFTLRLPEFILV 1208
++T +L+I + +D G Y S VG TA L++E +++ + +
Sbjct: 947 RMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEVQALD-RQSSGKDVRE 1005
Query: 1209 PANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKF--TLISDVKKRTLIIRKCTEDDQCEY 1266
+ A E ++ + KS + ++ + V + ++ +D Q +
Sbjct: 1006 STKSQAVADSSFTKEESKISQKEIKSFQGSSYEYEVQVFESVSQSSIHTAASVQDTQLCH 1065
Query: 1267 TCVLLDAKSTTKLKVEVVE----FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
T L +T+L E + PKI + ++ +K G L + + W
Sbjct: 1066 TASLSQIAESTELSKECAKESTGEAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWT 1125
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
I++ + K S + LTI V+ D G+Y + N+CG +++ P
Sbjct: 1126 HEGAKIEESERLKQSQNGNIQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEGAP 1184
Score = 70.5 bits (165), Expect = 6e-11
Identities = 40/116 (34%), Positives = 59/116 (50%), Gaps = 2/116 (1%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
++P P E P + L+ T +G +F+C+V G +++W+ + IKPS
Sbjct: 885 EVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPS 943
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGS 609
+ F+M +D L I E +PED GT+T VA NA G SST L +E D S
Sbjct: 944 RFFRMTQFEDTYQ-LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEVQALDRQS 998
Score = 46.8 bits (106), Expect = 9e-04
Identities = 49/214 (22%), Positives = 89/214 (41%), Gaps = 22/214 (10%)
Query: 728 KTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDG 784
K E P++ L+ + V+ G++ + + +TW ++ L +G
Sbjct: 1084 KESTGEAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEESERLKQSQNG 1143
Query: 785 DTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE--------EPTEENAE----- 831
+ +TI + V D+G+Y+ N G TSAV++VE E E+ E
Sbjct: 1144 NIQFLTICNVQLV-DQGLYSCIVHNDCGERTTSAVLSVEGAPESILHERIEQEIEMEMKA 1202
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE--TITQNFDGENIE 889
P+ + + + V K + P W++ I S+ +I + ++E
Sbjct: 1203 APVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLE 1262
Query: 890 LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
++ T V +D G+Y C ASN G S A +T+
Sbjct: 1263 ILRTQV---VDCGEYTCKASNEYGSVSCTATLTV 1293
Score = 46.8 bits (106), Expect = 9e-04
Identities = 28/102 (27%), Positives = 41/102 (40%), Gaps = 1/102 (0%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E+ E AP+ K+ P G +F C+++ P + WF+ I S D
Sbjct: 1193 EQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYES-DKCS 1251
Query: 559 YYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+++L I D G +TC A N G S T L V
Sbjct: 1252 IRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 1293
Score = 46.0 bits (104), Expect = 0.001
Identities = 52/240 (21%), Positives = 85/240 (35%), Gaps = 15/240 (6%)
Query: 488 LNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQT 547
L++ + + ++ E AP L+ G T QF C ++ +TW +
Sbjct: 1069 LSQIAESTELSKECAKESTGEAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEG 1128
Query: 548 AIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDH 607
A I+ S+ + + N+ L I V D G ++C+ N G E A LS
Sbjct: 1129 AKIEESERLKQS-QNGNIQFLTICNVQLVDQGLYSCIVHNDCG------ERTTSAVLSVE 1181
Query: 608 GSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAW 667
G+ ++ ++ P +K + V G C + + P W
Sbjct: 1182 GAPESILHERIEQEI----EMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQW 1237
Query: 668 LFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
G EI + S+ Y S L+I + G YT A N G S L +
Sbjct: 1238 FKAGREIYESDKCSIRSSK----YISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 1293
Score = 37.5 bits (83), Expect = 0.52
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 9/109 (8%)
Query: 509 APIFVEKLRPKHT------PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
A +FVE L T P+ T FEC+V + P + W + I+ S+ F++
Sbjct: 431 AKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVV-Q 488
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASST-TELIVEAPLSDHGSE 610
+ L+I ED+ +T V N A+ T T +++ + L D +E
Sbjct: 489 GKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSMLKDINAE 537
>AB209136-1|BAD92373.1| 2023|Homo sapiens Down syndrome cell adhesion
molecule isoform CHD2-42 precursor variant protein.
Length = 2023
Score = 169 bits (412), Expect = 7e-41
Identities = 283/1388 (20%), Positives = 521/1388 (37%), Gaps = 125/1388 (9%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P +++ + G+ V L + +G+P P W K+N P++ + T + +++
Sbjct: 236 PSILDGFEHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLEL--SGRFQKTVTGLLIEN 293
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
+ D G Y + N G A+ + V++P + P +++ + L
Sbjct: 294 IRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP-------RKVKSSVGSQVSLSC 346
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
VT ++WYRN EI++P + + G N E +I + + D G Y+C
Sbjct: 347 SVTGTEDQELSWYRNGEILNPGKNV--RITGINHENLIMDHMVKSDGGAYQCFVRKDKLS 404
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEI-SGMD 971
+ +V ++ + + + V L C T + W + I G
Sbjct: 405 AQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 463
Query: 972 HR---EIIQEGR-XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI--PEFIRKLQD 1025
HR I EG D GV +C + + + + P IR +++
Sbjct: 464 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKN 523
Query: 1026 F-EVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ +D I I + W ++ ++ + FE G ++ ++ DE
Sbjct: 524 ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV--DE 581
Query: 1085 GEYSC--ILRDESCTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRW 1139
GEY+C +++ + T++ V V P I + + + G + + GD + W
Sbjct: 582 GEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 641
Query: 1140 FKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT 1199
KDG I S + + L+I + L G Y+C N VE S
Sbjct: 642 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAA----AVEHQSQLIV 697
Query: 1200 LRLPEFILVPANTDA-YLTVEIPDETLD------VTW-YKKKSVIEDTEKFTL---ISDV 1248
P+F++ P + D Y I + + + + W + K + + + L I +
Sbjct: 698 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL 757
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
+L+I+ E+D Y C + + +K V+ P I Y +G
Sbjct: 758 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKE 817
Query: 1307 LLVDYQAFPQPNDEW-----IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
+ W I+N ++ + TK + ++L I D+G +
Sbjct: 818 MSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCH 877
Query: 1362 LENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
N+ G + +T+ + P PP + I ++ + +I + W + GNS I Y +E +
Sbjct: 878 AINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFD-GNSPITGYDIECKN 935
Query: 1422 IDTTEWIS---VKNITK--TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ W S K+++ +I ++ +S+Y R YA N + S+ S E E
Sbjct: 936 -KSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--NELTITADE 992
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXX 1536
P E L+ I+++ + + + + Y+ G + + ++
Sbjct: 993 AAPDGPPQEVHLEPISSQ-SIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISV 1051
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSC---VVGIQQKPVITISNEDI------------K 1581
F +G V +C G + +IT + ED+
Sbjct: 1052 DTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT 1111
Query: 1582 QKHKVGDEW--LVTAVIEGIPPP-EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
+ W L + GI VI++ N E + NITT + + + E +
Sbjct: 1112 SPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTN 1171
Query: 1639 HSSKYTIEASNTAGTSSVEV-TLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLE 1697
+S + G S ++ T D P P G V S V + W PPL G+
Sbjct: 1172 YSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG-VKAAAASASMVFVSWLPPLKLNGI- 1229
Query: 1698 LTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVG---FSEALE 1754
+ KY + P I + D +Y I L+ N +Y V+A G SE +
Sbjct: 1230 IRKYTVFCSHP-YPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIIT 1288
Query: 1755 SEPIVIKTA--------LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
EP+ A + P + + S + W + + G+P + +
Sbjct: 1289 VEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM--KDSNGTPSL-----V 1341
Query: 1807 KQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
+G++ I+ + + + A N G SD+ I + PP
Sbjct: 1342 TIDGRR----SIFSNGSFIIRTVKAEDSGYYSCIANNNWG------SDEIILNLQVQVPP 1391
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
QPR VS++TS S+TL W P NGGS I YI+++ + W + S +
Sbjct: 1392 DQPR-LTVSKTTSSSITLSWL-PGDNGGSSIRGYILQYSEDNSEQWGSF-PISPSERSYR 1448
Query: 1927 IENIKEKDEIIFRISAENTVG---VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
+EN+K F ++A+N VG +S E++++ E + A + V N++
Sbjct: 1449 LENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLI 1508
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
W DGG P+ + + R T+W + ++ + + DL E Y +++
Sbjct: 1509 --GWN----DGGCPITSFTLEYRPFGTTVWTTAQRTSLSK-SYILYDLQEATWYELQMRV 1561
Query: 2044 RNEIGLSE 2051
N G +E
Sbjct: 1562 CNSAGCAE 1569
Score = 130 bits (314), Expect = 5e-29
Identities = 192/828 (23%), Positives = 326/828 (39%), Gaps = 88/828 (10%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G + L C+ + PEPD WL +N+ + + + L I N++ G+
Sbjct: 250 GQRVELPCKALGHPEPDYRWL--------KDNMPLELSGRFQKTVTGLLIENIRPSDSGS 301
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
Y NR G A + L +K K I P K + G V LS V G ++
Sbjct: 302 YVCEVSNRYGTAKVIGRLYVKQPLK---ATISPRK-VKSSVGSQVSLSCSVTGTEDQELS 357
Query: 768 WCKNNKPVK-ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPT 826
W +N + + + G H I+ D G Y + A+ + +E+ T
Sbjct: 358 WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGT 417
Query: 827 EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQNFD 884
P I+ F E V + L+ V P+P+ITW +++ I S I+Q
Sbjct: 418 ------PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 471
Query: 885 GENIELVITNVDSE--IDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
E + N+ S D G Y+C A+NSAG + AR I+V ++ + K+
Sbjct: 472 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQAR--INVRGPASIRPM-KNITAIA 528
Query: 943 GKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC- 999
G+ + C+ S KWY N + +HR++ E D G C
Sbjct: 529 GRDTYIHCRVIGYPYYSIKWYKN-SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN 587
Query: 1000 -IVKDQ-ETSTMLVVKETIPEFIRKLQ--DFEVKEKDVAILEVEINSETADVVWERDGEI 1055
+V+ Q TS + V +P FI+ + F + ++ V + W++DG
Sbjct: 588 VLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRP 647
Query: 1056 IKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITR 1112
I P + L I N S+ G Y+CI R+E+ E +V +PP+ + +
Sbjct: 648 I-PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ 706
Query: 1113 LQNQKVNKGNKATF--EIELTKGDALVRWFKDGSEI-QF-----SNHIQLTIDGKKQKLK 1164
++Q G E +V F G+ + QF + IQ+ +G L
Sbjct: 707 PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG---SLL 763
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP--- 1221
I +D+G Y C+V N + S+ T+++P I NT +
Sbjct: 764 IKHVVEEDSGYYLCKVSNDVGADV----SKSMYLTVKIPAMITSYPNTTLATQGQKKEMS 819
Query: 1222 -----DETLDVTWYKKKSVIEDTEKFTLIS--DVKKR---TLIIRKCTEDDQCEYTCVLL 1271
++ + V W K+ +I L+S +V + TL I +D ++C +
Sbjct: 820 CTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAI 879
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
++ + +++ V+ PP E IK T+ + + N I I +
Sbjct: 880 NSYGEDRGIIQLTVQEPPD----PPEIEIKDVKARTITLRWTMGFDGNSP-ITGYDI--E 932
Query: 1331 CKHTKPSIDSKSASLTIKKVENT-------DAGIYKLRL--ENNCGHADVEMNVTI-LDK 1380
CK+ S DS + + N+ + Y +R+ +N G ++ +TI D+
Sbjct: 933 CKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADE 992
Query: 1381 PSPPGKP---NILEIDSSSINICWDEP-ENTGNSTIIYYVVEYQEIDT 1424
+P G P ++ I S SI + W P ++ N I Y + Y+E T
Sbjct: 993 AAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYST 1040
Score = 105 bits (253), Expect = 1e-21
Identities = 229/1171 (19%), Positives = 436/1171 (37%), Gaps = 124/1171 (10%)
Query: 1001 VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV----WERDGEII 1056
++ Q+ V++E P +R ++D + +VA+ + I S + WE+D +
Sbjct: 122 IRSQDVHIKAVLRE--PYTVR-VEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKD-TVS 177
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDE-GEYSCILRD-------ESCTAEVTVVE---L 1105
+++ G LYI++ D Y CI R +S +A + V +
Sbjct: 178 LVSGSRFLITSTG---ALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANS 234
Query: 1106 PPEIITRLQNQKVNKGNKATFEIE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P I+ +++K G + + L + RW KD ++ S Q T+ G L
Sbjct: 235 APSILDGFEHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LL 290
Query: 1165 IYDCDLDDAGEYSCEVGN----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
I + D+G Y CEV N +K L V++P + T+ P + + L+ +
Sbjct: 291 IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQP-LKATIS-PRKVKSSVGSQVSLSCSV 348
Query: 1221 PD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
E +++WY+ ++ + K I+ + LI+ + D Y C + K + +
Sbjct: 349 TGTEDQELSWYRNGEIL-NPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQD 407
Query: 1280 KVEVV--EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKKCKHTKP 1336
V+VV + PKI+ E + V+L+ + + P P W ++ I+K H
Sbjct: 408 YVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRIS 467
Query: 1337 SIDSKSAS----LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ + + L I + D G+Y+ N+ G + + + S NI I
Sbjct: 468 QMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAI 527
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFR 1452
G T I+ V + +W N+ + N + +
Sbjct: 528 --------------AGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL- 572
Query: 1453 AYAVNEVDISDASETTEYYKVIKETK-----IQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
+ EVD + + + ++ ++ P +P + + + + C+
Sbjct: 573 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVS 632
Query: 1508 VPQP-KVTWYRDGKKLK-TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETS 1562
P +TW +DG+ + + T +N Y CIA N+ VE
Sbjct: 633 GDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ 692
Query: 1563 CVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIW-YKNGNKLENDKEYNI 1621
+ ++ P + D Q G ++ EG P P ++W + G + + +
Sbjct: 693 SQLIVRVPPKFVVQPRD--QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIAL 750
Query: 1622 TTKEKT---SVIRIKELKRSHSSKYTIEASNTAG---TSSVEVTLKVYDK-PSKPEGPVI 1674
+ + + IK + S Y + SN G + S+ +T+K+ S P +
Sbjct: 751 NGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLA 810
Query: 1675 MREISRE-SVTIEWKPPLDDGGLELTKYAIEKH--EPDNNRW-IKVADVDRDV-ETYCIQ 1729
+ +E S T + P+ + ++ E P+ R+ + +V +V T I
Sbjct: 811 TQGQKKEMSCTAHGEKPI------IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQIL 864
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWF 1789
F A N G E I+ T + P + ++ + W
Sbjct: 865 PTVREDSGFFSCHAINSYG-----EDRGIIQLTVQEPPDPPEIEIKD--VKARTITLRWT 917
Query: 1790 PSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSI-----NTTYQFRIYARNE 1844
+G SPI Y +E K + W ++ +I ++TY R+YA+N
Sbjct: 918 MGF-DGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNR 976
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESN-GGSPITNYIIE 1903
IG S P S++ P P+ + +S+S+ + W P+ + I Y I
Sbjct: 977 IGKSEP--SNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIG 1034
Query: 1904 FK--TVKGKSWTKIVTV--GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
++ + G I++V G + ++N+ + + + A N G SQ +
Sbjct: 1035 YREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG--PSSQEIIT 1092
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDVTKTMWMEVGK 2018
VPS P ++ + SW T + L G+ + M E+G+
Sbjct: 1093 TTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIY--WANLMDGELGE 1150
Query: 2019 V-DVNTLKFNIR-DLSENHT-YMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
+ ++ T + ++ D E +T Y I++ A G + + S++ F ++ PG
Sbjct: 1151 IKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG--DGVRSEQIFT------RTKEDVPGP 1202
Query: 2076 QTEVXXXXXXXXXXXXXWLREHNMDADIRSY 2106
V WL ++ IR Y
Sbjct: 1203 PAGVKAAAASASMVFVSWLPPLKLNGIIRKY 1233
Score = 72.1 bits (169), Expect = 2e-11
Identities = 111/483 (22%), Positives = 188/483 (38%), Gaps = 39/483 (8%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP--DENISVAIE 685
+LE P + V + L C + P P I W + I+ IS I
Sbjct: 412 VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 471
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
S+ ++ S L I++ + G Y A N G +VL P I P+K++
Sbjct: 472 SEGNV-VSYLNISSSQVRDGGVYRCTANNSAG-----VVLYQARINVRGPASIRPMKNIT 525
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVY 803
G + +V+G P +I W KN+ P + + ++ + +K DEG Y
Sbjct: 526 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE-NNGTLKLSDVQKEVDEGEY 584
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
T ++ + +V +TV+ P P + F ++ ++ I V P+
Sbjct: 585 TCNVLVQPQLSTSQSVHVTVKVP------PFIQPFEFPRFSIGQRVFIPCVVVSGDLPI- 637
Query: 863 SITWYRNNEIISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
+ITW ++ I S +T N D + L I+N+ S + +G+Y C+A N A H +++
Sbjct: 638 TITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNL-SLMHNGNYTCIARNEAAAVEHQSQL 695
Query: 922 TIDVEKVTFVKHLQKSYETEEGKTVILECQT-SHTVSTKWYHNKKEISGMDHREIIQEGR 980
+ V V+ + + GK VIL C + V T + K + I GR
Sbjct: 696 IVRVPPKFVVQ--PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGR 753
Query: 981 XXXXXXXX-----XXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEV-KEK 1031
D G C V + + S + + IP I + + +
Sbjct: 754 IQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQG 813
Query: 1032 DVAILEVEINSETADVV-WERDGEIIKPKKNKY--DFEKRGH--IRKLYIRNTSVHDEGE 1086
+ + E +V WE++ II P+ +Y ++ G I L I T D G
Sbjct: 814 QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 873
Query: 1087 YSC 1089
+SC
Sbjct: 874 FSC 876
Score = 49.6 bits (113), Expect = 1e-04
Identities = 31/137 (22%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
+I N+ + ++ + VVAV G + ++ ++ K P +++ ++ + ++L
Sbjct: 1258 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1317
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGD----THSITILKPKKVKDEGVYTLKAENSE 811
+ VG+P P + W K++ +L T DG ++ I++ K +D G Y+ A N+
Sbjct: 1318 CKAVGDPSPAVKWMKDSNGTPSLVT-IDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNW 1376
Query: 812 GIAETSAVITVEEPTEE 828
G E + V+ P ++
Sbjct: 1377 GSDEIILNLQVQVPPDQ 1393
Score = 49.2 bits (112), Expect = 2e-04
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 5/102 (4%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
S+ + AP ++ + G V+ C+ G+P P W + ++ S FQ
Sbjct: 229 SDPANSAPSILDGFEHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQ----- 283
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
V L+I + P D+G++ C N G A L V+ PL
Sbjct: 284 KTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPL 325
Score = 48.8 bits (111), Expect = 2e-04
Identities = 50/230 (21%), Positives = 87/230 (37%), Gaps = 14/230 (6%)
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIA 666
H T + ++ +PP F +P+ Q G ++L C P P I
Sbjct: 674 HNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIV 733
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCS-VLKITNVKKFQEGTYTVVAVNREG-EASLPIV 724
W F VP +A+ + + + L I +V + G Y N G + S +
Sbjct: 734 WKFSKGAGVPQFQ-PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY 792
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK------AL 778
L +K P + + + QG+ +S G + W K ++ + +
Sbjct: 793 LTVKI----PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLV 848
Query: 779 PTKSDGDTHSITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
TK G+ T+ + P +D G ++ A NS G +TV+EP +
Sbjct: 849 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 898
Score = 46.0 bits (104), Expect = 0.001
Identities = 53/223 (23%), Positives = 94/223 (42%), Gaps = 10/223 (4%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEA--SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L++ ++K+ + V+A R G+ S I + K PP ++ + S
Sbjct: 1161 LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSW 1220
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ ++ G R +C + P ++ D+ S I + + V+ + A S G
Sbjct: 1221 LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV-AVTSAG 1279
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQ-EITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+S +ITVE P A+ P I F +T I L + +P P++ W +++
Sbjct: 1280 RGNSSEIITVE-PL---AKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSN 1335
Query: 872 IISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
TI + N +I V +E DSG Y C+A+N+ G
Sbjct: 1336 GTPSLVTIDGRRSIFSNGSFIIRTVKAE-DSGYYSCIANNNWG 1377
Score = 40.3 bits (90), Expect = 0.074
Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQDFQMYYDDDNVA-- 566
P FV + R + G V C EGYP P I W F + A + Q + ++
Sbjct: 701 PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG 760
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGF-ASSTTELIVEAP 603
+L+I+ V ED+G + C N G S + L V+ P
Sbjct: 761 SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP 798
Score = 39.5 bits (88), Expect = 0.13
Identities = 29/100 (29%), Positives = 37/100 (37%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQD--FQMYYDDDNVA 566
P + K V C V+G P P ITW I+K QM + NV
Sbjct: 418 PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 477
Query: 567 T-LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ L I D G + C A N+AG + V P S
Sbjct: 478 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 517
Score = 36.3 bits (80), Expect = 1.2
Identities = 17/78 (21%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C V G +++W+R I+ P ++ ++ N L++ + D G + C
Sbjct: 339 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRI--TGINHENLIMDHMVKSDGGAYQC 396
Query: 584 VAKNAAGFASSTTELIVE 601
+ A ++++E
Sbjct: 397 FVRKDKLSAQDYVQVVLE 414
Score = 34.3 bits (75), Expect = 4.9
Identities = 20/83 (24%), Positives = 33/83 (39%)
Query: 521 TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGT 580
TP + C+ G P P + W + + + + +IR V ED+G
Sbjct: 1308 TPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1367
Query: 581 FTCVAKNAAGFASSTTELIVEAP 603
++C+A N G L V+ P
Sbjct: 1368 YSCIANNNWGSDEIILNLQVQVP 1390
>AF217525-1|AAF27525.1| 2012|Homo sapiens Down syndrome cell adhesion
molecule protein.
Length = 2012
Score = 169 bits (410), Expect = 1e-40
Identities = 283/1388 (20%), Positives = 520/1388 (37%), Gaps = 125/1388 (9%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P +++ G+ V L + +G+P P W K+N P++ + T + +++
Sbjct: 225 PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLEL--SGRFQKTVTGLLIEN 282
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
+ D G Y + N G A+ + V++P + P +++ + L
Sbjct: 283 IRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP-------RKVKSSVGSQVSLSC 335
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
VT ++WYRN EI++P + + G N E +I + + D G Y+C
Sbjct: 336 SVTGTEDQELSWYRNGEILNPGKNV--RITGINHENLIMDHMVKSDGGAYQCFVRKDKLS 393
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEI-SGMD 971
+ +V ++ + + + V L C T + W + I G
Sbjct: 394 AQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 452
Query: 972 HR---EIIQEGR-XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI--PEFIRKLQD 1025
HR I EG D GV +C + + + + P IR +++
Sbjct: 453 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKN 512
Query: 1026 F-EVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ +D I I + W ++ ++ + FE G ++ ++ DE
Sbjct: 513 ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV--DE 570
Query: 1085 GEYSC--ILRDESCTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRW 1139
GEY+C +++ + T++ V V P I + + + G + + GD + W
Sbjct: 571 GEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 630
Query: 1140 FKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT 1199
KDG I S + + L+I + L G Y+C N VE S
Sbjct: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAA----AVEHQSQLIV 686
Query: 1200 LRLPEFILVPANTDA-YLTVEIPDETLD------VTW-YKKKSVIEDTEKFTL---ISDV 1248
P+F++ P + D Y I + + + + W + K + + + L I +
Sbjct: 687 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL 746
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
+L+I+ E+D Y C + + +K V+ P I Y +G
Sbjct: 747 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKE 806
Query: 1307 LLVDYQAFPQPNDEW-----IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
+ W I+N ++ + TK + ++L I D+G +
Sbjct: 807 MSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCH 866
Query: 1362 LENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
N+ G + +T+ + P PP + I ++ + +I + W + GNS I Y +E +
Sbjct: 867 AINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFD-GNSPITGYDIECKN 924
Query: 1422 IDTTEWIS---VKNITK--TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ W S K+++ +I ++ +S+Y R YA N + S+ S E E
Sbjct: 925 -KSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--NELTITADE 981
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXX 1536
P E L+ I+++ + + + + Y+ G + + ++
Sbjct: 982 AAPDGPPQEVHLEPISSQ-SIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISV 1040
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSC---VVGIQQKPVITISNEDI------------K 1581
F +G V +C G + +IT + ED+
Sbjct: 1041 DTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT 1100
Query: 1582 QKHKVGDEW--LVTAVIEGIPPP-EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
+ W L + GI VI++ N E + NITT + + + E +
Sbjct: 1101 SPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTN 1160
Query: 1639 HSSKYTIEASNTAGTSSVEV-TLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLE 1697
+S + G S ++ T D P P G V S V + W PPL G+
Sbjct: 1161 YSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG-VKAAAASASMVFVSWLPPLKLNGI- 1218
Query: 1698 LTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVG---FSEALE 1754
+ KY + P I + D +Y I L+ N +Y V+A G SE +
Sbjct: 1219 IRKYTVFCSHP-YPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIIT 1277
Query: 1755 SEPIVIKTA--------LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
EP+ A + P + + S + W + + G+P + +
Sbjct: 1278 VEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM--KDSNGTPSL-----V 1330
Query: 1807 KQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
+G++ I+ + + + A N G SD+ I + PP
Sbjct: 1331 TIDGRR----SIFSNGSFIIRTVKAEDSGYYSCIANNNWG------SDEIILNLQVQVPP 1380
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
QPR VS++TS S+TL W P NGGS I YI+++ + W + S +
Sbjct: 1381 DQPR-LTVSKTTSSSITLSWL-PGDNGGSSIRGYILQYSEDNSEQWGSF-PISPSERSYR 1437
Query: 1927 IENIKEKDEIIFRISAENTVG---VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
+EN+K F ++A+N VG +S E++++ E + A + V N++
Sbjct: 1438 LENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLI 1497
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
W DGG P+ + + R T+W + ++ + + DL E Y +++
Sbjct: 1498 --GWN----DGGCPITSFTLEYRPFGTTVWTTAQRTSLSK-SYILYDLQEATWYELQMRV 1550
Query: 2044 RNEIGLSE 2051
N G +E
Sbjct: 1551 CNSAGCAE 1558
Score = 130 bits (314), Expect = 5e-29
Identities = 192/828 (23%), Positives = 326/828 (39%), Gaps = 88/828 (10%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G + L C+ + PEPD WL +N+ + + + L I N++ G+
Sbjct: 239 GQRVELPCKALGHPEPDYRWL--------KDNMPLELSGRFQKTVTGLLIENIRPSDSGS 290
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
Y NR G A + L +K K I P K + G V LS V G ++
Sbjct: 291 YVCEVSNRYGTAKVIGRLYVKQPLK---ATISPRK-VKSSVGSQVSLSCSVTGTEDQELS 346
Query: 768 WCKNNKPVK-ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPT 826
W +N + + + G H I+ D G Y + A+ + +E+ T
Sbjct: 347 WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGT 406
Query: 827 EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQNFD 884
P I+ F E V + L+ V P+P+ITW +++ I S I+Q
Sbjct: 407 ------PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 460
Query: 885 GENIELVITNVDSE--IDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
E + N+ S D G Y+C A+NSAG + AR I+V ++ + K+
Sbjct: 461 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQAR--INVRGPASIRPM-KNITAIA 517
Query: 943 GKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC- 999
G+ + C+ S KWY N + +HR++ E D G C
Sbjct: 518 GRDTYIHCRVIGYPYYSIKWYKN-SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN 576
Query: 1000 -IVKDQ-ETSTMLVVKETIPEFIRKLQ--DFEVKEKDVAILEVEINSETADVVWERDGEI 1055
+V+ Q TS + V +P FI+ + F + ++ V + W++DG
Sbjct: 577 VLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRP 636
Query: 1056 IKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITR 1112
I P + L I N S+ G Y+CI R+E+ E +V +PP+ + +
Sbjct: 637 I-PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ 695
Query: 1113 LQNQKVNKGNKATF--EIELTKGDALVRWFKDGSEI-QF-----SNHIQLTIDGKKQKLK 1164
++Q G E +V F G+ + QF + IQ+ +G L
Sbjct: 696 PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG---SLL 752
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP--- 1221
I +D+G Y C+V N + S+ T+++P I NT +
Sbjct: 753 IKHVVEEDSGYYLCKVSNDVGADV----SKSMYLTVKIPAMITSYPNTTLATQGQKKEMS 808
Query: 1222 -----DETLDVTWYKKKSVIEDTEKFTLIS--DVKKR---TLIIRKCTEDDQCEYTCVLL 1271
++ + V W K+ +I L+S +V + TL I +D ++C +
Sbjct: 809 CTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAI 868
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
++ + +++ V+ PP E IK T+ + + N I I +
Sbjct: 869 NSYGEDRGIIQLTVQEPPD----PPEIEIKDVKARTITLRWTMGFDGNSP-ITGYDI--E 921
Query: 1331 CKHTKPSIDSKSASLTIKKVENT-------DAGIYKLRL--ENNCGHADVEMNVTI-LDK 1380
CK+ S DS + + N+ + Y +R+ +N G ++ +TI D+
Sbjct: 922 CKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADE 981
Query: 1381 PSPPGKP---NILEIDSSSINICWDEP-ENTGNSTIIYYVVEYQEIDT 1424
+P G P ++ I S SI + W P ++ N I Y + Y+E T
Sbjct: 982 AAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYST 1029
Score = 105 bits (251), Expect = 2e-21
Identities = 229/1171 (19%), Positives = 435/1171 (37%), Gaps = 124/1171 (10%)
Query: 1001 VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV----WERDGEII 1056
++ Q+ V++E P +R ++D + +VA+ + I S + WE+D +
Sbjct: 111 IRSQDVHIKAVLRE--PYTVR-VEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKD-TVS 166
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDE-GEYSCILRD-------ESCTAEVTVVE---L 1105
+++ G LYI++ D Y CI R +S +A + V +
Sbjct: 167 LVSGSRFLITSTG---ALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANS 223
Query: 1106 PPEIITRLQNQKVNKGNKATFEIE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P I+ ++K G + + L + RW KD ++ S Q T+ G L
Sbjct: 224 APSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LL 279
Query: 1165 IYDCDLDDAGEYSCEVGN----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
I + D+G Y CEV N +K L V++P + T+ P + + L+ +
Sbjct: 280 IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQP-LKATIS-PRKVKSSVGSQVSLSCSV 337
Query: 1221 PD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
E +++WY+ ++ + K I+ + LI+ + D Y C + K + +
Sbjct: 338 TGTEDQELSWYRNGEIL-NPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQD 396
Query: 1280 KVEVV--EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKKCKHTKP 1336
V+VV + PKI+ E + V+L+ + + P P W ++ I+K H
Sbjct: 397 YVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRIS 456
Query: 1337 SIDSKSAS----LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ + + L I + D G+Y+ N+ G + + + S NI I
Sbjct: 457 QMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAI 516
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFR 1452
G T I+ V + +W N+ + N + +
Sbjct: 517 --------------AGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL- 561
Query: 1453 AYAVNEVDISDASETTEYYKVIKETK-----IQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
+ EVD + + + ++ ++ P +P + + + + C+
Sbjct: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVS 621
Query: 1508 VPQP-KVTWYRDGKKLK-TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETS 1562
P +TW +DG+ + + T +N Y CIA N+ VE
Sbjct: 622 GDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ 681
Query: 1563 CVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIW-YKNGNKLENDKEYNI 1621
+ ++ P + D Q G ++ EG P P ++W + G + + +
Sbjct: 682 SQLIVRVPPKFVVQPRD--QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIAL 739
Query: 1622 TTKEKT---SVIRIKELKRSHSSKYTIEASNTAG---TSSVEVTLKVYDK-PSKPEGPVI 1674
+ + + IK + S Y + SN G + S+ +T+K+ S P +
Sbjct: 740 NGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLA 799
Query: 1675 MREISRE-SVTIEWKPPLDDGGLELTKYAIEKH--EPDNNRW-IKVADVDRDV-ETYCIQ 1729
+ +E S T + P+ + ++ E P+ R+ + +V +V T I
Sbjct: 800 TQGQKKEMSCTAHGEKPI------IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQIL 853
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWF 1789
F A N G E I+ T + P + ++ + W
Sbjct: 854 PTVREDSGFFSCHAINSYG-----EDRGIIQLTVQEPPDPPEIEIKD--VKARTITLRWT 906
Query: 1790 PSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSI-----NTTYQFRIYARNE 1844
+G SPI Y +E K + W ++ +I ++TY R+YA+N
Sbjct: 907 MGF-DGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNR 965
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESN-GGSPITNYIIE 1903
IG S P S++ P P+ + +S+S+ + W P+ + I Y I
Sbjct: 966 IGKSEP--SNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
Query: 1904 FK--TVKGKSWTKIVTV--GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
++ + G I++V G + ++N+ + + + A N G SQ +
Sbjct: 1024 YREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG--PSSQEIIT 1081
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDVTKTMWMEVGK 2018
VPS P ++ + SW T + L G+ + M E+G+
Sbjct: 1082 TTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIY--WANLMDGELGE 1139
Query: 2019 V-DVNTLKFNIR-DLSENHT-YMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
+ ++ T + ++ D E +T Y I++ A G + + S++ F ++ PG
Sbjct: 1140 IKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG--DGVRSEQIFT------RTKEDVPGP 1191
Query: 2076 QTEVXXXXXXXXXXXXXWLREHNMDADIRSY 2106
V WL ++ IR Y
Sbjct: 1192 PAGVKAAAASASMVFVSWLPPLKLNGIIRKY 1222
Score = 72.1 bits (169), Expect = 2e-11
Identities = 111/483 (22%), Positives = 188/483 (38%), Gaps = 39/483 (8%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP--DENISVAIE 685
+LE P + V + L C + P P I W + I+ IS I
Sbjct: 401 VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 460
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
S+ ++ S L I++ + G Y A N G +VL P I P+K++
Sbjct: 461 SEGNV-VSYLNISSSQVRDGGVYRCTANNSAG-----VVLYQARINVRGPASIRPMKNIT 514
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVY 803
G + +V+G P +I W KN+ P + + ++ + +K DEG Y
Sbjct: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE-NNGTLKLSDVQKEVDEGEY 573
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
T ++ + +V +TV+ P P + F ++ ++ I V P+
Sbjct: 574 TCNVLVQPQLSTSQSVHVTVKVP------PFIQPFEFPRFSIGQRVFIPCVVVSGDLPI- 626
Query: 863 SITWYRNNEIISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
+ITW ++ I S +T N D + L I+N+ S + +G+Y C+A N A H +++
Sbjct: 627 TITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNL-SLMHNGNYTCIARNEAAAVEHQSQL 684
Query: 922 TIDVEKVTFVKHLQKSYETEEGKTVILECQT-SHTVSTKWYHNKKEISGMDHREIIQEGR 980
+ V V+ + + GK VIL C + V T + K + I GR
Sbjct: 685 IVRVPPKFVVQ--PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGR 742
Query: 981 XXXXXXXX-----XXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEV-KEK 1031
D G C V + + S + + IP I + + +
Sbjct: 743 IQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQG 802
Query: 1032 DVAILEVEINSETADVV-WERDGEIIKPKKNKY--DFEKRGH--IRKLYIRNTSVHDEGE 1086
+ + E +V WE++ II P+ +Y ++ G I L I T D G
Sbjct: 803 QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 862
Query: 1087 YSC 1089
+SC
Sbjct: 863 FSC 865
Score = 49.6 bits (113), Expect = 1e-04
Identities = 31/137 (22%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
+I N+ + ++ + VVAV G + ++ ++ K P +++ ++ + ++L
Sbjct: 1247 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1306
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGD----THSITILKPKKVKDEGVYTLKAENSE 811
+ VG+P P + W K++ +L T DG ++ I++ K +D G Y+ A N+
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVT-IDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNW 1365
Query: 812 GIAETSAVITVEEPTEE 828
G E + V+ P ++
Sbjct: 1366 GSDEIILNLQVQVPPDQ 1382
Score = 48.8 bits (111), Expect = 2e-04
Identities = 50/230 (21%), Positives = 87/230 (37%), Gaps = 14/230 (6%)
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIA 666
H T + ++ +PP F +P+ Q G ++L C P P I
Sbjct: 663 HNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIV 722
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCS-VLKITNVKKFQEGTYTVVAVNREG-EASLPIV 724
W F VP +A+ + + + L I +V + G Y N G + S +
Sbjct: 723 WKFSKGAGVPQFQ-PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY 781
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK------AL 778
L +K P + + + QG+ +S G + W K ++ + +
Sbjct: 782 LTVKI----PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLV 837
Query: 779 PTKSDGDTHSITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
TK G+ T+ + P +D G ++ A NS G +TV+EP +
Sbjct: 838 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 887
Score = 48.4 bits (110), Expect = 3e-04
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 5/102 (4%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
S+ + AP ++ + G V+ C+ G+P P W + ++ S FQ
Sbjct: 218 SDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQK---- 273
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
V L+I + P D+G++ C N G A L V+ PL
Sbjct: 274 -TVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPL 314
Score = 46.0 bits (104), Expect = 0.001
Identities = 53/223 (23%), Positives = 94/223 (42%), Gaps = 10/223 (4%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEA--SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L++ ++K+ + V+A R G+ S I + K PP ++ + S
Sbjct: 1150 LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSW 1209
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ ++ G R +C + P ++ D+ S I + + V+ + A S G
Sbjct: 1210 LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV-AVTSAG 1268
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQ-EITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+S +ITVE P A+ P I F +T I L + +P P++ W +++
Sbjct: 1269 RGNSSEIITVE-PL---AKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSN 1324
Query: 872 IISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
TI + N +I V +E DSG Y C+A+N+ G
Sbjct: 1325 GTPSLVTIDGRRSIFSNGSFIIRTVKAE-DSGYYSCIANNNWG 1366
Score = 40.3 bits (90), Expect = 0.074
Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQDFQMYYDDDNVA-- 566
P FV + R + G V C EGYP P I W F + A + Q + ++
Sbjct: 690 PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG 749
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGF-ASSTTELIVEAP 603
+L+I+ V ED+G + C N G S + L V+ P
Sbjct: 750 SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP 787
Score = 39.5 bits (88), Expect = 0.13
Identities = 29/100 (29%), Positives = 37/100 (37%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQD--FQMYYDDDNVA 566
P + K V C V+G P P ITW I+K QM + NV
Sbjct: 407 PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 466
Query: 567 T-LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ L I D G + C A N+AG + V P S
Sbjct: 467 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 506
Score = 36.3 bits (80), Expect = 1.2
Identities = 17/78 (21%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C V G +++W+R I+ P ++ ++ N L++ + D G + C
Sbjct: 328 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRI--TGINHENLIMDHMVKSDGGAYQC 385
Query: 584 VAKNAAGFASSTTELIVE 601
+ A ++++E
Sbjct: 386 FVRKDKLSAQDYVQVVLE 403
Score = 34.3 bits (75), Expect = 4.9
Identities = 20/83 (24%), Positives = 33/83 (39%)
Query: 521 TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGT 580
TP + C+ G P P + W + + + + +IR V ED+G
Sbjct: 1297 TPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356
Query: 581 FTCVAKNAAGFASSTTELIVEAP 603
++C+A N G L V+ P
Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVP 1379
>AF023450-1|AAC17967.1| 1571|Homo sapiens Down syndrome cell adhesion
molecule protein.
Length = 1571
Score = 169 bits (410), Expect = 1e-40
Identities = 283/1388 (20%), Positives = 520/1388 (37%), Gaps = 125/1388 (9%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P +++ G+ V L + +G+P P W K+N P++ + T + +++
Sbjct: 225 PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLEL--SGRFQKTVTGLLIEN 282
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
+ D G Y + N G A+ + V++P + P +++ + L
Sbjct: 283 IRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP-------RKVKSSVGSQVSLSC 335
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
VT ++WYRN EI++P + + G N E +I + + D G Y+C
Sbjct: 336 SVTGTEDQELSWYRNGEILNPGKNV--RITGINHENLIMDHMVKSDGGAYQCFVRKDKLS 393
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEI-SGMD 971
+ +V ++ + + + V L C T + W + I G
Sbjct: 394 AQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 452
Query: 972 HR---EIIQEGR-XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI--PEFIRKLQD 1025
HR I EG D GV +C + + + + P IR +++
Sbjct: 453 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKN 512
Query: 1026 F-EVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ +D I I + W ++ ++ + FE G ++ ++ DE
Sbjct: 513 ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV--DE 570
Query: 1085 GEYSC--ILRDESCTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRW 1139
GEY+C +++ + T++ V V P I + + + G + + GD + W
Sbjct: 571 GEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 630
Query: 1140 FKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT 1199
KDG I S + + L+I + L G Y+C N VE S
Sbjct: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAA----AVEHQSQLIV 686
Query: 1200 LRLPEFILVPANTDA-YLTVEIPDETLD------VTW-YKKKSVIEDTEKFTL---ISDV 1248
P+F++ P + D Y I + + + + W + K + + + L I +
Sbjct: 687 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL 746
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
+L+I+ E+D Y C + + +K V+ P I Y +G
Sbjct: 747 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKE 806
Query: 1307 LLVDYQAFPQPNDEW-----IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
+ W I+N ++ + TK + ++L I D+G +
Sbjct: 807 MSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCH 866
Query: 1362 LENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
N+ G + +T+ + P PP + I ++ + +I + W + GNS I Y +E +
Sbjct: 867 AINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFD-GNSPITGYDIECKN 924
Query: 1422 IDTTEWIS---VKNITK--TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ W S K+++ +I ++ +S+Y R YA N + S+ S E E
Sbjct: 925 -KSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--NELTITADE 981
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXX 1536
P E L+ I+++ + + + + Y+ G + + ++
Sbjct: 982 AAPDGPPQEVHLEPISSQ-SIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISV 1040
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSC---VVGIQQKPVITISNEDI------------K 1581
F +G V +C G + +IT + ED+
Sbjct: 1041 DTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT 1100
Query: 1582 QKHKVGDEW--LVTAVIEGIPPP-EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
+ W L + GI VI++ N E + NITT + + + E +
Sbjct: 1101 SPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTN 1160
Query: 1639 HSSKYTIEASNTAGTSSVEV-TLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLE 1697
+S + G S ++ T D P P G V S V + W PPL G+
Sbjct: 1161 YSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG-VKAAAASASMVFVSWLPPLKLNGI- 1218
Query: 1698 LTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVG---FSEALE 1754
+ KY + P I + D +Y I L+ N +Y V+A G SE +
Sbjct: 1219 IRKYTVFCSHP-YPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIIT 1277
Query: 1755 SEPIVIKTA--------LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
EP+ A + P + + S + W + + G+P + +
Sbjct: 1278 VEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM--KDSNGTPSL-----V 1330
Query: 1807 KQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
+G++ I+ + + + A N G SD+ I + PP
Sbjct: 1331 TIDGRR----SIFSNGSFIIRTVKAEDSGYYSCIANNNWG------SDEIILNLQVQVPP 1380
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
QPR VS++TS S+TL W P NGGS I YI+++ + W + S +
Sbjct: 1381 DQPR-LTVSKTTSSSITLSWL-PGDNGGSSIRGYILQYSEDNSEQWGSF-PISPSERSYR 1437
Query: 1927 IENIKEKDEIIFRISAENTVG---VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
+EN+K F ++A+N VG +S E++++ E + A + V N++
Sbjct: 1438 LENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLI 1497
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
W DGG P+ + + R T+W + ++ + + DL E Y +++
Sbjct: 1498 --GWN----DGGCPITSFTLEYRPFGTTVWTTAQRTSLSK-SYILYDLQEATWYELQMRV 1550
Query: 2044 RNEIGLSE 2051
N G +E
Sbjct: 1551 CNSAGCAE 1558
Score = 130 bits (314), Expect = 5e-29
Identities = 192/828 (23%), Positives = 326/828 (39%), Gaps = 88/828 (10%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G + L C+ + PEPD WL +N+ + + + L I N++ G+
Sbjct: 239 GQRVELPCKALGHPEPDYRWL--------KDNMPLELSGRFQKTVTGLLIENIRPSDSGS 290
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
Y NR G A + L +K K I P K + G V LS V G ++
Sbjct: 291 YVCEVSNRYGTAKVIGRLYVKQPLK---ATISPRK-VKSSVGSQVSLSCSVTGTEDQELS 346
Query: 768 WCKNNKPVK-ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPT 826
W +N + + + G H I+ D G Y + A+ + +E+ T
Sbjct: 347 WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGT 406
Query: 827 EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQNFD 884
P I+ F E V + L+ V P+P+ITW +++ I S I+Q
Sbjct: 407 ------PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 460
Query: 885 GENIELVITNVDSE--IDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
E + N+ S D G Y+C A+NSAG + AR I+V ++ + K+
Sbjct: 461 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQAR--INVRGPASIRPM-KNITAIA 517
Query: 943 GKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC- 999
G+ + C+ S KWY N + +HR++ E D G C
Sbjct: 518 GRDTYIHCRVIGYPYYSIKWYKN-SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN 576
Query: 1000 -IVKDQ-ETSTMLVVKETIPEFIRKLQ--DFEVKEKDVAILEVEINSETADVVWERDGEI 1055
+V+ Q TS + V +P FI+ + F + ++ V + W++DG
Sbjct: 577 VLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRP 636
Query: 1056 IKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITR 1112
I P + L I N S+ G Y+CI R+E+ E +V +PP+ + +
Sbjct: 637 I-PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ 695
Query: 1113 LQNQKVNKGNKATF--EIELTKGDALVRWFKDGSEI-QF-----SNHIQLTIDGKKQKLK 1164
++Q G E +V F G+ + QF + IQ+ +G L
Sbjct: 696 PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG---SLL 752
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP--- 1221
I +D+G Y C+V N + S+ T+++P I NT +
Sbjct: 753 IKHVVEEDSGYYLCKVSNDVGADV----SKSMYLTVKIPAMITSYPNTTLATQGQKKEMS 808
Query: 1222 -----DETLDVTWYKKKSVIEDTEKFTLIS--DVKKR---TLIIRKCTEDDQCEYTCVLL 1271
++ + V W K+ +I L+S +V + TL I +D ++C +
Sbjct: 809 CTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAI 868
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
++ + +++ V+ PP E IK T+ + + N I I +
Sbjct: 869 NSYGEDRGIIQLTVQEPPD----PPEIEIKDVKARTITLRWTMGFDGNSP-ITGYDI--E 921
Query: 1331 CKHTKPSIDSKSASLTIKKVENT-------DAGIYKLRL--ENNCGHADVEMNVTI-LDK 1380
CK+ S DS + + N+ + Y +R+ +N G ++ +TI D+
Sbjct: 922 CKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADE 981
Query: 1381 PSPPGKP---NILEIDSSSINICWDEP-ENTGNSTIIYYVVEYQEIDT 1424
+P G P ++ I S SI + W P ++ N I Y + Y+E T
Sbjct: 982 AAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYST 1029
Score = 105 bits (251), Expect = 2e-21
Identities = 229/1171 (19%), Positives = 435/1171 (37%), Gaps = 124/1171 (10%)
Query: 1001 VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV----WERDGEII 1056
++ Q+ V++E P +R ++D + +VA+ + I S + WE+D +
Sbjct: 111 IRSQDVHIKAVLRE--PYTVR-VEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKD-TVS 166
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDE-GEYSCILRD-------ESCTAEVTVVE---L 1105
+++ G LYI++ D Y CI R +S +A + V +
Sbjct: 167 LVSGSRFLITSTG---ALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANS 223
Query: 1106 PPEIITRLQNQKVNKGNKATFEIE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P I+ ++K G + + L + RW KD ++ S Q T+ G L
Sbjct: 224 APSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LL 279
Query: 1165 IYDCDLDDAGEYSCEVGN----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
I + D+G Y CEV N +K L V++P + T+ P + + L+ +
Sbjct: 280 IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQP-LKATIS-PRKVKSSVGSQVSLSCSV 337
Query: 1221 PD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
E +++WY+ ++ + K I+ + LI+ + D Y C + K + +
Sbjct: 338 TGTEDQELSWYRNGEIL-NPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQD 396
Query: 1280 KVEVV--EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKKCKHTKP 1336
V+VV + PKI+ E + V+L+ + + P P W ++ I+K H
Sbjct: 397 YVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRIS 456
Query: 1337 SIDSKSAS----LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ + + L I + D G+Y+ N+ G + + + S NI I
Sbjct: 457 QMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAI 516
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFR 1452
G T I+ V + +W N+ + N + +
Sbjct: 517 --------------AGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL- 561
Query: 1453 AYAVNEVDISDASETTEYYKVIKETK-----IQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
+ EVD + + + ++ ++ P +P + + + + C+
Sbjct: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVS 621
Query: 1508 VPQP-KVTWYRDGKKLK-TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETS 1562
P +TW +DG+ + + T +N Y CIA N+ VE
Sbjct: 622 GDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ 681
Query: 1563 CVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIW-YKNGNKLENDKEYNI 1621
+ ++ P + D Q G ++ EG P P ++W + G + + +
Sbjct: 682 SQLIVRVPPKFVVQPRD--QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIAL 739
Query: 1622 TTKEKT---SVIRIKELKRSHSSKYTIEASNTAG---TSSVEVTLKVYDK-PSKPEGPVI 1674
+ + + IK + S Y + SN G + S+ +T+K+ S P +
Sbjct: 740 NGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLA 799
Query: 1675 MREISRE-SVTIEWKPPLDDGGLELTKYAIEKH--EPDNNRW-IKVADVDRDV-ETYCIQ 1729
+ +E S T + P+ + ++ E P+ R+ + +V +V T I
Sbjct: 800 TQGQKKEMSCTAHGEKPI------IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQIL 853
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWF 1789
F A N G E I+ T + P + ++ + W
Sbjct: 854 PTVREDSGFFSCHAINSYG-----EDRGIIQLTVQEPPDPPEIEIKD--VKARTITLRWT 906
Query: 1790 PSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSI-----NTTYQFRIYARNE 1844
+G SPI Y +E K + W ++ +I ++TY R+YA+N
Sbjct: 907 MGF-DGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNR 965
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESN-GGSPITNYIIE 1903
IG S P S++ P P+ + +S+S+ + W P+ + I Y I
Sbjct: 966 IGKSEP--SNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
Query: 1904 FK--TVKGKSWTKIVTV--GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
++ + G I++V G + ++N+ + + + A N G SQ +
Sbjct: 1024 YREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG--PSSQEIIT 1081
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDVTKTMWMEVGK 2018
VPS P ++ + SW T + L G+ + M E+G+
Sbjct: 1082 TTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIY--WANLMDGELGE 1139
Query: 2019 V-DVNTLKFNIR-DLSENHT-YMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
+ ++ T + ++ D E +T Y I++ A G + + S++ F ++ PG
Sbjct: 1140 IKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG--DGVRSEQIFT------RTKEDVPGP 1191
Query: 2076 QTEVXXXXXXXXXXXXXWLREHNMDADIRSY 2106
V WL ++ IR Y
Sbjct: 1192 PAGVKAAAASASMVFVSWLPPLKLNGIIRKY 1222
Score = 72.1 bits (169), Expect = 2e-11
Identities = 111/483 (22%), Positives = 188/483 (38%), Gaps = 39/483 (8%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP--DENISVAIE 685
+LE P + V + L C + P P I W + I+ IS I
Sbjct: 401 VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 460
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
S+ ++ S L I++ + G Y A N G +VL P I P+K++
Sbjct: 461 SEGNV-VSYLNISSSQVRDGGVYRCTANNSAG-----VVLYQARINVRGPASIRPMKNIT 514
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVY 803
G + +V+G P +I W KN+ P + + ++ + +K DEG Y
Sbjct: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE-NNGTLKLSDVQKEVDEGEY 573
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
T ++ + +V +TV+ P P + F ++ ++ I V P+
Sbjct: 574 TCNVLVQPQLSTSQSVHVTVKVP------PFIQPFEFPRFSIGQRVFIPCVVVSGDLPI- 626
Query: 863 SITWYRNNEIISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
+ITW ++ I S +T N D + L I+N+ S + +G+Y C+A N A H +++
Sbjct: 627 TITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNL-SLMHNGNYTCIARNEAAAVEHQSQL 684
Query: 922 TIDVEKVTFVKHLQKSYETEEGKTVILECQT-SHTVSTKWYHNKKEISGMDHREIIQEGR 980
+ V V+ + + GK VIL C + V T + K + I GR
Sbjct: 685 IVRVPPKFVVQ--PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGR 742
Query: 981 XXXXXXXX-----XXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEV-KEK 1031
D G C V + + S + + IP I + + +
Sbjct: 743 IQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQG 802
Query: 1032 DVAILEVEINSETADVV-WERDGEIIKPKKNKY--DFEKRGH--IRKLYIRNTSVHDEGE 1086
+ + E +V WE++ II P+ +Y ++ G I L I T D G
Sbjct: 803 QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 862
Query: 1087 YSC 1089
+SC
Sbjct: 863 FSC 865
Score = 49.6 bits (113), Expect = 1e-04
Identities = 31/137 (22%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
+I N+ + ++ + VVAV G + ++ ++ K P +++ ++ + ++L
Sbjct: 1247 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1306
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGD----THSITILKPKKVKDEGVYTLKAENSE 811
+ VG+P P + W K++ +L T DG ++ I++ K +D G Y+ A N+
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVT-IDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNW 1365
Query: 812 GIAETSAVITVEEPTEE 828
G E + V+ P ++
Sbjct: 1366 GSDEIILNLQVQVPPDQ 1382
Score = 48.8 bits (111), Expect = 2e-04
Identities = 50/230 (21%), Positives = 87/230 (37%), Gaps = 14/230 (6%)
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIA 666
H T + ++ +PP F +P+ Q G ++L C P P I
Sbjct: 663 HNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIV 722
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCS-VLKITNVKKFQEGTYTVVAVNREG-EASLPIV 724
W F VP +A+ + + + L I +V + G Y N G + S +
Sbjct: 723 WKFSKGAGVPQFQ-PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY 781
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK------AL 778
L +K P + + + QG+ +S G + W K ++ + +
Sbjct: 782 LTVKI----PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLV 837
Query: 779 PTKSDGDTHSITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
TK G+ T+ + P +D G ++ A NS G +TV+EP +
Sbjct: 838 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 887
Score = 48.4 bits (110), Expect = 3e-04
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 5/102 (4%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
S+ + AP ++ + G V+ C+ G+P P W + ++ S FQ
Sbjct: 218 SDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQK---- 273
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
V L+I + P D+G++ C N G A L V+ PL
Sbjct: 274 -TVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPL 314
Score = 46.0 bits (104), Expect = 0.001
Identities = 53/223 (23%), Positives = 94/223 (42%), Gaps = 10/223 (4%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEA--SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L++ ++K+ + V+A R G+ S I + K PP ++ + S
Sbjct: 1150 LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSW 1209
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ ++ G R +C + P ++ D+ S I + + V+ + A S G
Sbjct: 1210 LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV-AVTSAG 1268
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQ-EITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+S +ITVE P A+ P I F +T I L + +P P++ W +++
Sbjct: 1269 RGNSSEIITVE-PL---AKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSN 1324
Query: 872 IISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
TI + N +I V +E DSG Y C+A+N+ G
Sbjct: 1325 GTPSLVTIDGRRSIFSNGSFIIRTVKAE-DSGYYSCIANNNWG 1366
Score = 41.9 bits (94), Expect = 0.024
Identities = 85/392 (21%), Positives = 132/392 (33%), Gaps = 29/392 (7%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT 1438
D P PP +S + + W P N I Y V T IS +
Sbjct: 1187 DVPGPPAGVKAAAASASMVFVSWLPPLKL-NGIIRKYTVFCSHPYPTV-ISEFEASPDSF 1244
Query: 1439 S--IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP- 1495
S I NL N Y AV ++SE + E ++P T P
Sbjct: 1245 SYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI-----ITVEPLAKAPARILTFSGTVTTPW 1299
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGK---KLKT--AKATYENRXXXXXXXXXXXXXXXYKC 1550
+DI L C G P P V W +D L T + + + Y C
Sbjct: 1300 MKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC 1359
Query: 1551 IAFNDHGEVETSCVVGIQ---QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWY 1607
IA N+ G E + +Q +P +T+S + WL ++ Y
Sbjct: 1360 IANNNWGSDEIILNLQVQVPPDQPRLTVSK---TTSSSITLSWLPGDNGGSSIRGYILQY 1416
Query: 1608 KNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVE--VTLKVYDK 1665
N E + I+ E++ R++ LK K+T+ A N G + + K K
Sbjct: 1417 SEDNS-EQWGSFPISPSERS--YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGK 1473
Query: 1666 -PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE 1724
P + + I+ V + +DGG +T + +E W +
Sbjct: 1474 EPQFSKEQELFASINTTRVRLN-LIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLS-K 1531
Query: 1725 TYCIQKLNENCEYMFRVIAQNPVGFSEALESE 1756
+Y + L E Y ++ N G +E E
Sbjct: 1532 SYILYDLQEATWYELQMRVCNSAGCAEKQAKE 1563
Score = 40.3 bits (90), Expect = 0.074
Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQDFQMYYDDDNVA-- 566
P FV + R + G V C EGYP P I W F + A + Q + ++
Sbjct: 690 PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG 749
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGF-ASSTTELIVEAP 603
+L+I+ V ED+G + C N G S + L V+ P
Sbjct: 750 SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP 787
Score = 39.5 bits (88), Expect = 0.13
Identities = 29/100 (29%), Positives = 37/100 (37%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQD--FQMYYDDDNVA 566
P + K V C V+G P P ITW I+K QM + NV
Sbjct: 407 PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 466
Query: 567 T-LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ L I D G + C A N+AG + V P S
Sbjct: 467 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 506
Score = 36.3 bits (80), Expect = 1.2
Identities = 17/78 (21%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C V G +++W+R I+ P ++ ++ N L++ + D G + C
Sbjct: 328 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRI--TGINHENLIMDHMVKSDGGAYQC 385
Query: 584 VAKNAAGFASSTTELIVE 601
+ A ++++E
Sbjct: 386 FVRKDKLSAQDYVQVVLE 403
Score = 34.3 bits (75), Expect = 4.9
Identities = 20/83 (24%), Positives = 33/83 (39%)
Query: 521 TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGT 580
TP + C+ G P P + W + + + + +IR V ED+G
Sbjct: 1297 TPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356
Query: 581 FTCVAKNAAGFASSTTELIVEAP 603
++C+A N G L V+ P
Sbjct: 1357 YSCIANNNWGSDEIILNLQVQVP 1379
>AF023449-1|AAC17966.1| 1896|Homo sapiens Down syndrome cell adhesion
molecule protein.
Length = 1896
Score = 169 bits (410), Expect = 1e-40
Identities = 283/1388 (20%), Positives = 520/1388 (37%), Gaps = 125/1388 (9%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P +++ G+ V L + +G+P P W K+N P++ + T + +++
Sbjct: 211 PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLEL--SGRFQKTVTGLLIEN 268
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
+ D G Y + N G A+ + V++P + P +++ + L
Sbjct: 269 IRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP-------RKVKSSVGSQVSLSC 321
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
VT ++WYRN EI++P + + G N E +I + + D G Y+C
Sbjct: 322 SVTGTEDQELSWYRNGEILNPGKNV--RITGINHENLIMDHMVKSDGGAYQCFVRKDKLS 379
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEI-SGMD 971
+ +V ++ + + + V L C T + W + I G
Sbjct: 380 AQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 438
Query: 972 HR---EIIQEGR-XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI--PEFIRKLQD 1025
HR I EG D GV +C + + + + P IR +++
Sbjct: 439 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKN 498
Query: 1026 F-EVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ +D I I + W ++ ++ + FE G ++ ++ DE
Sbjct: 499 ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV--DE 556
Query: 1085 GEYSC--ILRDESCTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRW 1139
GEY+C +++ + T++ V V P I + + + G + + GD + W
Sbjct: 557 GEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 616
Query: 1140 FKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT 1199
KDG I S + + L+I + L G Y+C N VE S
Sbjct: 617 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAA----AVEHQSQLIV 672
Query: 1200 LRLPEFILVPANTDA-YLTVEIPDETLD------VTW-YKKKSVIEDTEKFTL---ISDV 1248
P+F++ P + D Y I + + + + W + K + + + L I +
Sbjct: 673 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL 732
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
+L+I+ E+D Y C + + +K V+ P I Y +G
Sbjct: 733 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKE 792
Query: 1307 LLVDYQAFPQPNDEW-----IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
+ W I+N ++ + TK + ++L I D+G +
Sbjct: 793 MSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCH 852
Query: 1362 LENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
N+ G + +T+ + P PP + I ++ + +I + W + GNS I Y +E +
Sbjct: 853 AINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFD-GNSPITGYDIECKN 910
Query: 1422 IDTTEWIS---VKNITK--TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ W S K+++ +I ++ +S+Y R YA N + S+ S E E
Sbjct: 911 -KSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--NELTITADE 967
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXX 1536
P E L+ I+++ + + + + Y+ G + + ++
Sbjct: 968 AAPDGPPQEVHLEPISSQ-SIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISV 1026
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSC---VVGIQQKPVITISNEDI------------K 1581
F +G V +C G + +IT + ED+
Sbjct: 1027 DTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT 1086
Query: 1582 QKHKVGDEW--LVTAVIEGIPPP-EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
+ W L + GI VI++ N E + NITT + + + E +
Sbjct: 1087 SPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTN 1146
Query: 1639 HSSKYTIEASNTAGTSSVEV-TLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLE 1697
+S + G S ++ T D P P G V S V + W PPL G+
Sbjct: 1147 YSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG-VKAAAASASMVFVSWLPPLKLNGI- 1204
Query: 1698 LTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVG---FSEALE 1754
+ KY + P I + D +Y I L+ N +Y V+A G SE +
Sbjct: 1205 IRKYTVFCSHP-YPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIIT 1263
Query: 1755 SEPIVIKTA--------LDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
EP+ A + P + + S + W + + G+P + +
Sbjct: 1264 VEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM--KDSNGTPSL-----V 1316
Query: 1807 KQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
+G++ I+ + + + A N G SD+ I + PP
Sbjct: 1317 TIDGRR----SIFSNGSFIIRTVKAEDSGYYSCIANNNWG------SDEIILNLQVQVPP 1366
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
QPR VS++TS S+TL W P NGGS I YI+++ + W + S +
Sbjct: 1367 DQPR-LTVSKTTSSSITLSWL-PGDNGGSSIRGYILQYSEDNSEQWGSF-PISPSERSYR 1423
Query: 1927 IENIKEKDEIIFRISAENTVG---VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
+EN+K F ++A+N VG +S E++++ E + A + V N++
Sbjct: 1424 LENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLI 1483
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
W DGG P+ + + R T+W + ++ + + DL E Y +++
Sbjct: 1484 --GWN----DGGCPITSFTLEYRPFGTTVWTTAQRTSLSK-SYILYDLQEATWYELQMRV 1536
Query: 2044 RNEIGLSE 2051
N G +E
Sbjct: 1537 CNSAGCAE 1544
Score = 130 bits (314), Expect = 5e-29
Identities = 192/828 (23%), Positives = 326/828 (39%), Gaps = 88/828 (10%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G + L C+ + PEPD WL +N+ + + + L I N++ G+
Sbjct: 225 GQRVELPCKALGHPEPDYRWL--------KDNMPLELSGRFQKTVTGLLIENIRPSDSGS 276
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
Y NR G A + L +K K I P K + G V LS V G ++
Sbjct: 277 YVCEVSNRYGTAKVIGRLYVKQPLK---ATISPRK-VKSSVGSQVSLSCSVTGTEDQELS 332
Query: 768 WCKNNKPVK-ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPT 826
W +N + + + G H I+ D G Y + A+ + +E+ T
Sbjct: 333 WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGT 392
Query: 827 EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQNFD 884
P I+ F E V + L+ V P+P+ITW +++ I S I+Q
Sbjct: 393 ------PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 446
Query: 885 GENIELVITNVDSE--IDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
E + N+ S D G Y+C A+NSAG + AR I+V ++ + K+
Sbjct: 447 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQAR--INVRGPASIRPM-KNITAIA 503
Query: 943 GKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC- 999
G+ + C+ S KWY N + +HR++ E D G C
Sbjct: 504 GRDTYIHCRVIGYPYYSIKWYKN-SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN 562
Query: 1000 -IVKDQ-ETSTMLVVKETIPEFIRKLQ--DFEVKEKDVAILEVEINSETADVVWERDGEI 1055
+V+ Q TS + V +P FI+ + F + ++ V + W++DG
Sbjct: 563 VLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRP 622
Query: 1056 IKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITR 1112
I P + L I N S+ G Y+CI R+E+ E +V +PP+ + +
Sbjct: 623 I-PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ 681
Query: 1113 LQNQKVNKGNKATF--EIELTKGDALVRWFKDGSEI-QF-----SNHIQLTIDGKKQKLK 1164
++Q G E +V F G+ + QF + IQ+ +G L
Sbjct: 682 PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG---SLL 738
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP--- 1221
I +D+G Y C+V N + S+ T+++P I NT +
Sbjct: 739 IKHVVEEDSGYYLCKVSNDVGADV----SKSMYLTVKIPAMITSYPNTTLATQGQKKEMS 794
Query: 1222 -----DETLDVTWYKKKSVIEDTEKFTLIS--DVKKR---TLIIRKCTEDDQCEYTCVLL 1271
++ + V W K+ +I L+S +V + TL I +D ++C +
Sbjct: 795 CTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAI 854
Query: 1272 DAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
++ + +++ V+ PP E IK T+ + + N I I +
Sbjct: 855 NSYGEDRGIIQLTVQEPPD----PPEIEIKDVKARTITLRWTMGFDGNSP-ITGYDI--E 907
Query: 1331 CKHTKPSIDSKSASLTIKKVENT-------DAGIYKLRL--ENNCGHADVEMNVTI-LDK 1380
CK+ S DS + + N+ + Y +R+ +N G ++ +TI D+
Sbjct: 908 CKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADE 967
Query: 1381 PSPPGKP---NILEIDSSSINICWDEP-ENTGNSTIIYYVVEYQEIDT 1424
+P G P ++ I S SI + W P ++ N I Y + Y+E T
Sbjct: 968 AAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYST 1015
Score = 105 bits (251), Expect = 2e-21
Identities = 229/1171 (19%), Positives = 435/1171 (37%), Gaps = 124/1171 (10%)
Query: 1001 VKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV----WERDGEII 1056
++ Q+ V++E P +R ++D + +VA+ + I S + WE+D +
Sbjct: 97 IRSQDVHIKAVLRE--PYTVR-VEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKD-TVS 152
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDE-GEYSCILRD-------ESCTAEVTVVE---L 1105
+++ G LYI++ D Y CI R +S +A + V +
Sbjct: 153 LVSGSRFLITSTG---ALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANS 209
Query: 1106 PPEIITRLQNQKVNKGNKATFEIE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P I+ ++K G + + L + RW KD ++ S Q T+ G L
Sbjct: 210 APSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LL 265
Query: 1165 IYDCDLDDAGEYSCEVGN----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
I + D+G Y CEV N +K L V++P + T+ P + + L+ +
Sbjct: 266 IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQP-LKATIS-PRKVKSSVGSQVSLSCSV 323
Query: 1221 PD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
E +++WY+ ++ + K I+ + LI+ + D Y C + K + +
Sbjct: 324 TGTEDQELSWYRNGEIL-NPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQD 382
Query: 1280 KVEVV--EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKKCKHTKP 1336
V+VV + PKI+ E + V+L+ + + P P W ++ I+K H
Sbjct: 383 YVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRIS 442
Query: 1337 SIDSKSAS----LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ + + L I + D G+Y+ N+ G + + + S NI I
Sbjct: 443 QMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAI 502
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFR 1452
G T I+ V + +W N+ + N + +
Sbjct: 503 --------------AGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL- 547
Query: 1453 AYAVNEVDISDASETTEYYKVIKETK-----IQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
+ EVD + + + ++ ++ P +P + + + + C+
Sbjct: 548 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVS 607
Query: 1508 VPQP-KVTWYRDGKKLK-TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETS 1562
P +TW +DG+ + + T +N Y CIA N+ VE
Sbjct: 608 GDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ 667
Query: 1563 CVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIW-YKNGNKLENDKEYNI 1621
+ ++ P + D Q G ++ EG P P ++W + G + + +
Sbjct: 668 SQLIVRVPPKFVVQPRD--QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIAL 725
Query: 1622 TTKEKT---SVIRIKELKRSHSSKYTIEASNTAG---TSSVEVTLKVYDK-PSKPEGPVI 1674
+ + + IK + S Y + SN G + S+ +T+K+ S P +
Sbjct: 726 NGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLA 785
Query: 1675 MREISRE-SVTIEWKPPLDDGGLELTKYAIEKH--EPDNNRW-IKVADVDRDV-ETYCIQ 1729
+ +E S T + P+ + ++ E P+ R+ + +V +V T I
Sbjct: 786 TQGQKKEMSCTAHGEKPI------IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQIL 839
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWF 1789
F A N G E I+ T + P + ++ + W
Sbjct: 840 PTVREDSGFFSCHAINSYG-----EDRGIIQLTVQEPPDPPEIEIKD--VKARTITLRWT 892
Query: 1790 PSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSI-----NTTYQFRIYARNE 1844
+G SPI Y +E K + W ++ +I ++TY R+YA+N
Sbjct: 893 MGF-DGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNR 951
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESN-GGSPITNYIIE 1903
IG S P S++ P P+ + +S+S+ + W P+ + I Y I
Sbjct: 952 IGKSEP--SNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIG 1009
Query: 1904 FK--TVKGKSWTKIVTV--GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
++ + G I++V G + ++N+ + + + A N G SQ +
Sbjct: 1010 YREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG--PSSQEIIT 1067
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDVTKTMWMEVGK 2018
VPS P ++ + SW T + L G+ + M E+G+
Sbjct: 1068 TTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIY--WANLMDGELGE 1125
Query: 2019 V-DVNTLKFNIR-DLSENHT-YMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
+ ++ T + ++ D E +T Y I++ A G + + S++ F ++ PG
Sbjct: 1126 IKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG--DGVRSEQIFT------RTKEDVPGP 1177
Query: 2076 QTEVXXXXXXXXXXXXXWLREHNMDADIRSY 2106
V WL ++ IR Y
Sbjct: 1178 PAGVKAAAASASMVFVSWLPPLKLNGIIRKY 1208
Score = 72.1 bits (169), Expect = 2e-11
Identities = 111/483 (22%), Positives = 188/483 (38%), Gaps = 39/483 (8%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP--DENISVAIE 685
+LE P + V + L C + P P I W + I+ IS I
Sbjct: 387 VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 446
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
S+ ++ S L I++ + G Y A N G +VL P I P+K++
Sbjct: 447 SEGNV-VSYLNISSSQVRDGGVYRCTANNSAG-----VVLYQARINVRGPASIRPMKNIT 500
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVY 803
G + +V+G P +I W KN+ P + + ++ + +K DEG Y
Sbjct: 501 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE-NNGTLKLSDVQKEVDEGEY 559
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
T ++ + +V +TV+ P P + F ++ ++ I V P+
Sbjct: 560 TCNVLVQPQLSTSQSVHVTVKVP------PFIQPFEFPRFSIGQRVFIPCVVVSGDLPI- 612
Query: 863 SITWYRNNEIISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
+ITW ++ I S +T N D + L I+N+ S + +G+Y C+A N A H +++
Sbjct: 613 TITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNL-SLMHNGNYTCIARNEAAAVEHQSQL 670
Query: 922 TIDVEKVTFVKHLQKSYETEEGKTVILECQT-SHTVSTKWYHNKKEISGMDHREIIQEGR 980
+ V V+ + + GK VIL C + V T + K + I GR
Sbjct: 671 IVRVPPKFVVQ--PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGR 728
Query: 981 XXXXXXXX-----XXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEV-KEK 1031
D G C V + + S + + IP I + + +
Sbjct: 729 IQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQG 788
Query: 1032 DVAILEVEINSETADVV-WERDGEIIKPKKNKY--DFEKRGH--IRKLYIRNTSVHDEGE 1086
+ + E +V WE++ II P+ +Y ++ G I L I T D G
Sbjct: 789 QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 848
Query: 1087 YSC 1089
+SC
Sbjct: 849 FSC 851
Score = 49.6 bits (113), Expect = 1e-04
Identities = 31/137 (22%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
+I N+ + ++ + VVAV G + ++ ++ K P +++ ++ + ++L
Sbjct: 1233 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1292
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGD----THSITILKPKKVKDEGVYTLKAENSE 811
+ VG+P P + W K++ +L T DG ++ I++ K +D G Y+ A N+
Sbjct: 1293 CKAVGDPSPAVKWMKDSNGTPSLVT-IDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNW 1351
Query: 812 GIAETSAVITVEEPTEE 828
G E + V+ P ++
Sbjct: 1352 GSDEIILNLQVQVPPDQ 1368
Score = 48.8 bits (111), Expect = 2e-04
Identities = 50/230 (21%), Positives = 87/230 (37%), Gaps = 14/230 (6%)
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIA 666
H T + ++ +PP F +P+ Q G ++L C P P I
Sbjct: 649 HNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIV 708
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCS-VLKITNVKKFQEGTYTVVAVNREG-EASLPIV 724
W F VP +A+ + + + L I +V + G Y N G + S +
Sbjct: 709 WKFSKGAGVPQFQ-PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY 767
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK------AL 778
L +K P + + + QG+ +S G + W K ++ + +
Sbjct: 768 LTVKI----PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLV 823
Query: 779 PTKSDGDTHSITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
TK G+ T+ + P +D G ++ A NS G +TV+EP +
Sbjct: 824 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 873
Score = 48.4 bits (110), Expect = 3e-04
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 5/102 (4%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
S+ + AP ++ + G V+ C+ G+P P W + ++ S FQ
Sbjct: 204 SDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQK---- 259
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
V L+I + P D+G++ C N G A L V+ PL
Sbjct: 260 -TVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPL 300
Score = 46.0 bits (104), Expect = 0.001
Identities = 53/223 (23%), Positives = 94/223 (42%), Gaps = 10/223 (4%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEA--SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L++ ++K+ + V+A R G+ S I + K PP ++ + S
Sbjct: 1136 LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSW 1195
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ ++ G R +C + P ++ D+ S I + + V+ + A S G
Sbjct: 1196 LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV-AVTSAG 1254
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQ-EITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+S +ITVE P A+ P I F +T I L + +P P++ W +++
Sbjct: 1255 RGNSSEIITVE-PL---AKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSN 1310
Query: 872 IISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
TI + N +I V +E DSG Y C+A+N+ G
Sbjct: 1311 GTPSLVTIDGRRSIFSNGSFIIRTVKAE-DSGYYSCIANNNWG 1352
Score = 40.3 bits (90), Expect = 0.074
Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQDFQMYYDDDNVA-- 566
P FV + R + G V C EGYP P I W F + A + Q + ++
Sbjct: 676 PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG 735
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGF-ASSTTELIVEAP 603
+L+I+ V ED+G + C N G S + L V+ P
Sbjct: 736 SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP 773
Score = 39.5 bits (88), Expect = 0.13
Identities = 29/100 (29%), Positives = 37/100 (37%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQD--FQMYYDDDNVA 566
P + K V C V+G P P ITW I+K QM + NV
Sbjct: 393 PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 452
Query: 567 T-LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ L I D G + C A N+AG + V P S
Sbjct: 453 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 492
Score = 36.3 bits (80), Expect = 1.2
Identities = 17/78 (21%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C V G +++W+R I+ P ++ ++ N L++ + D G + C
Sbjct: 314 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRI--TGINHENLIMDHMVKSDGGAYQC 371
Query: 584 VAKNAAGFASSTTELIVE 601
+ A ++++E
Sbjct: 372 FVRKDKLSAQDYVQVVLE 389
Score = 34.3 bits (75), Expect = 4.9
Identities = 20/83 (24%), Positives = 33/83 (39%)
Query: 521 TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGT 580
TP + C+ G P P + W + + + + +IR V ED+G
Sbjct: 1283 TPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1342
Query: 581 FTCVAKNAAGFASSTTELIVEAP 603
++C+A N G L V+ P
Sbjct: 1343 YSCIANNNWGSDEIILNLQVQVP 1365
>AF289030-1|AAL56711.1| 1746|Homo sapiens Down syndrome cell adhesion
molecule splice variant protein.
Length = 1746
Score = 162 bits (394), Expect = 1e-38
Identities = 279/1364 (20%), Positives = 511/1364 (37%), Gaps = 125/1364 (9%)
Query: 759 VGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
+G+P P W K+N P++ + T + +++ + D G Y + N G A+
Sbjct: 1 LGHPEPDYRWLKDNMPLEL--SGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIG 58
Query: 819 VITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET 878
+ V++P + P +++ + L VT ++WYRN EI++P +
Sbjct: 59 RLYVKQPLKATISP-------RKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN 111
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
+ G N E +I + + D G Y+C + +V ++ + +
Sbjct: 112 V--RITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV 169
Query: 939 ETEEGKTVILECQTSHTV--STKWYHNKKEI-SGMDHR---EIIQEGRXXXXXXXXXXXX 992
+ V L C T + W + I G HR I EG
Sbjct: 170 -VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQV 228
Query: 993 -DVGVIKCIVKDQETSTMLVVKETI--PEFIRKLQDFE-VKEKDVAILEVEINSETADVV 1048
D GV +C + + + + P IR +++ + +D I I +
Sbjct: 229 RDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIK 288
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC--ILRDESCTAE-VTVVEL 1105
W ++ ++ + FE G ++ ++ DEGEY+C +++ + T++ V V
Sbjct: 289 WYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV--DEGEYTCNVLVQPQLSTSQSVHVTVK 346
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDA--LVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
P I + + + G + + GD + W KDG I S + + L
Sbjct: 347 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSL 406
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDA-YLTVEIPD 1222
+I + L G Y+C N VE S P+F++ P + D Y I +
Sbjct: 407 RISNLSLMHNGNYTCIARNEAAA----VEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILN 462
Query: 1223 ETLD------VTW-YKKKSVIEDTEKFTL---ISDVKKRTLIIRKCTEDDQCEYTCVLLD 1272
+ + + W + K + + + L I + +L+I+ E+D Y C + +
Sbjct: 463 CSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSN 522
Query: 1273 --AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEW-----IVNS 1325
+K V+ P I Y +G + W I+N
Sbjct: 523 DVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINP 582
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
++ + TK + ++L I D+G + N+ G + +T+ + P PP
Sbjct: 583 EMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP- 641
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS---VKNITK--TQTSI 1440
+ I ++ + +I + W + GNS I Y +E + + W S K+++ +I
Sbjct: 642 EIEIKDVKARTITLRWTMGFD-GNSPITGYDIECKN-KSDSWDSAQRTKDVSPQLNSATI 699
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
++ +S+Y R YA N + S+ S E E P E L+ I+++ + +
Sbjct: 700 IDIHPSSTYSIRMYAKNRIGKSEPS--NELTITADEAAPDGPPQEVHLEPISSQ-SIRVT 756
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
+ + Y+ G + + ++ F +G V
Sbjct: 757 WKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVV 816
Query: 1561 TSC---VVGIQQKPVITISNEDI------------KQKHKVGDEW--LVTAVIEGIPPP- 1602
+C G + +IT + ED+ + W L + GI
Sbjct: 817 QACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGF 876
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV-TLK 1661
VI++ N E + NITT + + + E ++S + G S ++ T
Sbjct: 877 RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT 936
Query: 1662 VYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
D P P G V S V + W PPL G+ + KY + P I +
Sbjct: 937 KEDVPGPPAG-VKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHP-YPTVISEFEASP 993
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVG---FSEALESEPIVIKTA--------LDVPSXX 1770
D +Y I L+ N +Y V+A G SE + EP+ A + P
Sbjct: 994 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1053
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLS 1830
+ + S + W + + G+P + + +G++ I+ +
Sbjct: 1054 DIVLPCKAVGDPSPAVKWM--KDSNGTPSL-----VTIDGRR----SIFSNGSFIIRTVK 1102
Query: 1831 INTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPE 1890
+ + A N G SD+ I + PP QPR VS++TS S+TL W P
Sbjct: 1103 AEDSGYYSCIANNNWG------SDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSWL-PG 1154
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG--- 1947
NGGS I YI+++ + W + S + +EN+K F ++A+N VG
Sbjct: 1155 DNGGSSIRGYILQYSEDNSEQWGSF-PISPSERSYRLENLKCGTWYKFTLTAQNGVGPGR 1213
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRD 2007
+S E++++ E + A + V N++ W DGG P+ + + R
Sbjct: 1214 ISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLI--GWN----DGGCPITSFTLEYRP 1267
Query: 2008 VTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSE 2051
T+W + ++ + + DL E Y +++ N G +E
Sbjct: 1268 FGTTVWTTAQRTSLSK-SYILYDLQEATWYELQMRVCNSAGCAE 1310
Score = 124 bits (299), Expect = 4e-27
Identities = 189/815 (23%), Positives = 320/815 (39%), Gaps = 88/815 (10%)
Query: 661 PEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEAS 720
PEPD WL +N+ + + + L I N++ G+Y NR G A
Sbjct: 4 PEPDYRWL--------KDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAK 55
Query: 721 LPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALP 779
+ L +K K I P K + G V LS V G ++W +N + +
Sbjct: 56 VIGRLYVKQPLK---ATISPRK-VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN 111
Query: 780 TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRF 839
+ G H I+ D G Y + A+ + +E+ T P I+ F
Sbjct: 112 VRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGT------PKIISAF 165
Query: 840 QEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQNFDGENIELVITNVDS 897
E V + L+ V P+P+ITW +++ I S I+Q E + N+ S
Sbjct: 166 SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISS 225
Query: 898 E--IDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT--S 953
D G Y+C A+NSAG + AR I+V ++ + K+ G+ + C+
Sbjct: 226 SQVRDGGVYRCTANNSAGVVLYQAR--INVRGPASIRPM-KNITAIAGRDTYIHCRVIGY 282
Query: 954 HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC--IVKDQ-ETSTML 1010
S KWY N + +HR++ E D G C +V+ Q TS +
Sbjct: 283 PYYSIKWYKN-SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSV 341
Query: 1011 VVKETIPEFIRKLQ--DFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKR 1068
V +P FI+ + F + ++ V + W++DG I P +
Sbjct: 342 HVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPI-PGSLGVTIDNI 400
Query: 1069 GHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRLQNQKVNKGNKAT 1125
L I N S+ G Y+CI R+E+ E +V +PP+ + + ++Q G
Sbjct: 401 DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVI 460
Query: 1126 F--EIELTKGDALVRWFKDGSEI-QF-----SNHIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
E +V F G+ + QF + IQ+ +G L I +D+G Y
Sbjct: 461 LNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG---SLLIKHVVEEDSGYYL 517
Query: 1178 CEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP--------DETLDVTW 1229
C+V N + S+ T+++P I NT + ++ + V W
Sbjct: 518 CKVSNDVGADV----SKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRW 573
Query: 1230 YKKKSVIEDTEKFTLIS--DVKKR---TLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV- 1283
K+ +I L+S +V + TL I +D ++C +++ + +++
Sbjct: 574 EKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLT 633
Query: 1284 VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
V+ PP E IK T+ + + N I I +CK+ S DS
Sbjct: 634 VQEPPD----PPEIEIKDVKARTITLRWTMGFDGNSP-ITGYDI--ECKNKSDSWDSAQR 686
Query: 1344 SLTIKKVENT-------DAGIYKLRL--ENNCGHADVEMNVTI-LDKPSPPGKP---NIL 1390
+ + N+ + Y +R+ +N G ++ +TI D+ +P G P ++
Sbjct: 687 TKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLE 746
Query: 1391 EIDSSSINICWDEP-ENTGNSTIIYYVVEYQEIDT 1424
I S SI + W P ++ N I Y + Y+E T
Sbjct: 747 PISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYST 781
Score = 102 bits (245), Expect = 1e-20
Identities = 199/1018 (19%), Positives = 375/1018 (36%), Gaps = 101/1018 (9%)
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN----SKCTAILTVEE 1193
RW KD ++ S Q T+ G L I + D+G Y CEV N +K L V++
Sbjct: 9 RWLKDNMPLELSGRFQKTVTG----LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQ 64
Query: 1194 PSINFTLRLPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
P + T+ P + + L+ + E +++WY+ ++ + K I+ +
Sbjct: 65 P-LKATIS-PRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEIL-NPGKNVRITGINHEN 121
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV--EFPPKIVDYEREYRIKRGSDVTLLVD 1310
LI+ + D Y C + K + + V+VV + PKI+ E + V+L+ +
Sbjct: 122 LIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCN 181
Query: 1311 YQAFPQPNDEWIVNSK-IIKKCKHTKPSIDSKSAS----LTIKKVENTDAGIYKLRLENN 1365
+ P P W ++ I+K H + + + L I + D G+Y+ N+
Sbjct: 182 VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNS 241
Query: 1366 CGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTT 1425
G + + + S NI I G T I+ V +
Sbjct: 242 AGVVLYQARINVRGPASIRPMKNITAI--------------AGRDTYIHCRVIGYPYYSI 287
Query: 1426 EWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETK-----IQ 1480
+W N+ + N + + + EVD + + + ++ ++
Sbjct: 288 KWYKNSNLLPFNHRQVAFENNGTLKL-SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVK 346
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQP-KVTWYRDGKKLK-TAKATYEN---RXXX 1535
P +P + + + + C+ P +TW +DG+ + + T +N
Sbjct: 347 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSL 406
Query: 1536 XXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV 1595
Y CIA N+ VE + ++ P + D Q G ++
Sbjct: 407 RISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRD--QDGIYGKAVILNCS 464
Query: 1596 IEGIPPPEVIW-YKNGNKLENDKEYNITTKEKT---SVIRIKELKRSHSSKYTIEASNTA 1651
EG P P ++W + G + + + + + + IK + S Y + SN
Sbjct: 465 AEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDV 524
Query: 1652 G---TSSVEVTLKVYDK-PSKPEGPVIMREISRE-SVTIEWKPPLDDGGLELTKYAIEKH 1706
G + S+ +T+K+ S P + + +E S T + P+ + ++ E
Sbjct: 525 GADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPI------IVRWEKEDR 578
Query: 1707 --EPDNNRW-IKVADVDRDV-ETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT 1762
P+ R+ + +V +V T I F A N G E I+ T
Sbjct: 579 IINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYG-----EDRGIIQLT 633
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXX 1822
+ P + ++ + W +G SPI Y +E K + W
Sbjct: 634 VQEPPDPPEIEIKD--VKARTITLRWTMGF-DGNSPITGYDIECKNKSDSWDSAQRTKDV 690
Query: 1823 XARIQKLSI-----NTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES 1877
++ +I ++TY R+YA+N IG S P S++ P P+ +
Sbjct: 691 SPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEP--SNELTITADEAAPDGPPQEVHLEPI 748
Query: 1878 TSRSVTLKWTEPESN-GGSPITNYIIEFK--TVKGKSWTKIVTV--GGSVHEHCIENIKE 1932
+S+S+ + W P+ + I Y I ++ + G I++V G + ++N+ +
Sbjct: 749 SSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNK 808
Query: 1933 KDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW 1992
+ + A N G SQ + VPS P ++ + SW T
Sbjct: 809 FTQYGLVVQACNRAGTG--PSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSK 866
Query: 1993 DG-GAPLLGYNIAIRDVTKTMWMEVGKV-DVNTLKFNIR-DLSENHT-YMIRIYARNEIG 2048
+ L G+ + M E+G++ ++ T + ++ D E +T Y I++ A G
Sbjct: 867 EALNGILQGFRVIY--WANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG 924
Query: 2049 LSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLREHNMDADIRSY 2106
+ + S++ F ++ PG V WL ++ IR Y
Sbjct: 925 --DGVRSEQIFT------RTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKY 974
Score = 85.8 bits (203), Expect = 2e-15
Identities = 127/581 (21%), Positives = 226/581 (38%), Gaps = 57/581 (9%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
GS + L C + + +++W GE + P +N+ + + ++ + ++ K G
Sbjct: 80 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLI-----MDHMVKSDGGA 134
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
Y R+ + S +++ E P++I +V E V L V G P PTIT
Sbjct: 135 YQCFV--RKDKLSAQDYVQVVL-EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTIT 191
Query: 768 WCKNNKPVK-------ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
W ++ P+ + S+G+ S + +V+D GVY A NS G+ A I
Sbjct: 192 WTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI 251
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
V P I + IT + RV P SI WY+N+ ++ P
Sbjct: 252 NVRGPAS--------IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL-PFNHRQ 302
Query: 881 QNFDGENIELVITNVDSEIDSGDYKC-VASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
F+ N L +++V E+D G+Y C V +S VT+ V F++ +
Sbjct: 303 VAFE-NNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVP--PFIQPFEFP-R 358
Query: 940 TEEGKTVILEC---QTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
G+ V + C ++ W + + I G I G
Sbjct: 359 FSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGN 418
Query: 997 IKCIVKDQ----ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWER 1051
CI +++ E + L+V+ P+F+ + +D + IL +VW+
Sbjct: 419 YTCIARNEAAAVEHQSQLIVR-VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKF 477
Query: 1052 DGEIIKPKKNKYDFEKRGHI---RKLYIRNTSVHDEGEYSCILRDESCTAEVT-----VV 1103
P+ R + L I++ D G Y C + ++ A+V+ V
Sbjct: 478 SKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSND-VGADVSKSMYLTV 536
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIEL-TKGDALVRWFKDGSEI--QFSNHIQLTID-GK 1159
++P I + +G K + +VRW K+ I + + ++ T + G+
Sbjct: 537 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGE 596
Query: 1160 K--QKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEP 1194
+ L+I +D+G +SC G + LTV+EP
Sbjct: 597 EVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEP 637
Score = 72.1 bits (169), Expect = 2e-11
Identities = 111/483 (22%), Positives = 188/483 (38%), Gaps = 39/483 (8%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP--DENISVAIE 685
+LE P + V + L C + P P I W + I+ IS I
Sbjct: 153 VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 212
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
S+ ++ S L I++ + G Y A N G +VL P I P+K++
Sbjct: 213 SEGNV-VSYLNISSSQVRDGGVYRCTANNSAG-----VVLYQARINVRGPASIRPMKNIT 266
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVY 803
G + +V+G P +I W KN+ P + + ++ + +K DEG Y
Sbjct: 267 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE-NNGTLKLSDVQKEVDEGEY 325
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
T ++ + +V +TV+ P P + F ++ ++ I V P+
Sbjct: 326 TCNVLVQPQLSTSQSVHVTVKVP------PFIQPFEFPRFSIGQRVFIPCVVVSGDLPI- 378
Query: 863 SITWYRNNEIISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
+ITW ++ I S +T N D + L I+N+ S + +G+Y C+A N A H +++
Sbjct: 379 TITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNL-SLMHNGNYTCIARNEAAAVEHQSQL 436
Query: 922 TIDVEKVTFVKHLQKSYETEEGKTVILECQT-SHTVSTKWYHNKKEISGMDHREIIQEGR 980
+ V V+ + + GK VIL C + V T + K + I GR
Sbjct: 437 IVRVPPKFVVQ--PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGR 494
Query: 981 XXXXXXXX-----XXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEV-KEK 1031
D G C V + + S + + IP I + + +
Sbjct: 495 IQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQG 554
Query: 1032 DVAILEVEINSETADVV-WERDGEIIKPKKNKY--DFEKRGH--IRKLYIRNTSVHDEGE 1086
+ + E +V WE++ II P+ +Y ++ G I L I T D G
Sbjct: 555 QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 614
Query: 1087 YSC 1089
+SC
Sbjct: 615 FSC 617
Score = 49.6 bits (113), Expect = 1e-04
Identities = 31/137 (22%), Positives = 67/137 (48%), Gaps = 5/137 (3%)
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
+I N+ + ++ + VVAV G + ++ ++ K P +++ ++ + ++L
Sbjct: 999 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1058
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGD----THSITILKPKKVKDEGVYTLKAENSE 811
+ VG+P P + W K++ +L T DG ++ I++ K +D G Y+ A N+
Sbjct: 1059 CKAVGDPSPAVKWMKDSNGTPSLVT-IDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNW 1117
Query: 812 GIAETSAVITVEEPTEE 828
G E + V+ P ++
Sbjct: 1118 GSDEIILNLQVQVPPDQ 1134
Score = 48.8 bits (111), Expect = 2e-04
Identities = 50/230 (21%), Positives = 87/230 (37%), Gaps = 14/230 (6%)
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIA 666
H T + ++ +PP F +P+ Q G ++L C P P I
Sbjct: 415 HNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIV 474
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCS-VLKITNVKKFQEGTYTVVAVNREG-EASLPIV 724
W F VP +A+ + + + L I +V + G Y N G + S +
Sbjct: 475 WKFSKGAGVPQFQ-PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY 533
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK------AL 778
L +K P + + + QG+ +S G + W K ++ + +
Sbjct: 534 LTVKI----PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLV 589
Query: 779 PTKSDGDTHSITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
TK G+ T+ + P +D G ++ A NS G +TV+EP +
Sbjct: 590 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 639
Score = 46.0 bits (104), Expect = 0.001
Identities = 53/223 (23%), Positives = 94/223 (42%), Gaps = 10/223 (4%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEA--SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L++ ++K+ + V+A R G+ S I + K PP ++ + S
Sbjct: 902 LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSW 961
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+ ++ G R +C + P ++ D+ S I + + V+ + A S G
Sbjct: 962 LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV-AVTSAG 1020
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQ-EITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+S +ITVE P A+ P I F +T I L + +P P++ W +++
Sbjct: 1021 RGNSSEIITVE-PL---AKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSN 1076
Query: 872 IISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
TI + N +I V +E DSG Y C+A+N+ G
Sbjct: 1077 GTPSLVTIDGRRSIFSNGSFIIRTVKAE-DSGYYSCIANNNWG 1118
Score = 40.3 bits (90), Expect = 0.074
Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQDFQMYYDDDNVA-- 566
P FV + R + G V C EGYP P I W F + A + Q + ++
Sbjct: 442 PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG 501
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGF-ASSTTELIVEAP 603
+L+I+ V ED+G + C N G S + L V+ P
Sbjct: 502 SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP 539
Score = 39.5 bits (88), Expect = 0.13
Identities = 29/100 (29%), Positives = 37/100 (37%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQD--FQMYYDDDNVA 566
P + K V C V+G P P ITW I+K QM + NV
Sbjct: 159 PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 218
Query: 567 T-LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ L I D G + C A N+AG + V P S
Sbjct: 219 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 258
Score = 38.7 bits (86), Expect = 0.23
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Query: 535 GYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASS 594
G+P P W + ++ S FQ V L+I + P D+G++ C N G A
Sbjct: 2 GHPEPDYRWLKDNMPLELSGRFQK-----TVTGLLIENIRPSDSGSYVCEVSNRYGTAKV 56
Query: 595 TTELIVEAPL 604
L V+ PL
Sbjct: 57 IGRLYVKQPL 66
Score = 36.3 bits (80), Expect = 1.2
Identities = 17/78 (21%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C V G +++W+R I+ P ++ ++ N L++ + D G + C
Sbjct: 80 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRI--TGINHENLIMDHMVKSDGGAYQC 137
Query: 584 VAKNAAGFASSTTELIVE 601
+ A ++++E
Sbjct: 138 FVRKDKLSAQDYVQVVLE 155
Score = 34.3 bits (75), Expect = 4.9
Identities = 20/83 (24%), Positives = 33/83 (39%)
Query: 521 TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGT 580
TP + C+ G P P + W + + + + +IR V ED+G
Sbjct: 1049 TPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1108
Query: 581 FTCVAKNAAGFASSTTELIVEAP 603
++C+A N G L V+ P
Sbjct: 1109 YSCIANNNWGSDEIILNLQVQVP 1131
>X66276-1|CAA46987.1| 1138|Homo sapiens C protein protein.
Length = 1138
Score = 161 bits (392), Expect = 2e-38
Identities = 112/436 (25%), Positives = 197/436 (45%), Gaps = 12/436 (2%)
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
VE+ +V W ++G+ ++P KY FE L I N + D+ EY DE C+
Sbjct: 273 VELADPKLEVKWNKNGQELRPS-TKYIFEDTRCQSILNIDNCQMTDDSEYYVTAGDEKCS 331
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQF-SNHIQLTI 1156
E+ V E P + +L++ G + E E+++ DA V+WFK+G EI ++ +
Sbjct: 332 TELLVREPPIMVTKQLEDTTDYCGERVELECEVSEDDAQVKWFKNGEEIILVQTRYRIRV 391
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
+GKK L I DA +YS + +A L+V+ + L + V + L
Sbjct: 392 EGKKHILIIEGATKADAADYSVMTTGGQSSAKLSVDLKPLKILTPLTDQT-VNLGKEICL 450
Query: 1217 TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKST 1276
EI E + W K ++++++ ++ + L+I +D+ +Y T
Sbjct: 451 KCEI-SENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIDHALTEDEGDYVFAPDAYNVT 509
Query: 1277 TKLKVEVVEFPPKIV----DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKKC 1331
KV V++ PPKI+ D + + G+ + L + P P W K I++
Sbjct: 510 LPAKVHVID-PPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGS 568
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILE 1391
+ S++L I E D+G+Y + L+N G A + V ++D P PP P + E
Sbjct: 569 GRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTE 628
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLK--TNSSY 1449
+ + W+ P G S I+ Y +E ++ ++ W+ + +T+ + K +Y
Sbjct: 629 VGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAY 688
Query: 1450 RFRAYAVNEVDISDAS 1465
R +AVN + IS S
Sbjct: 689 EVRIFAVNAIGISKPS 704
Score = 103 bits (247), Expect = 7e-21
Identities = 142/647 (21%), Positives = 266/647 (41%), Gaps = 49/647 (7%)
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXX 984
+ F K L Y+ ++G V + + + KW N +E+ + I ++ R
Sbjct: 249 KSAAFAKILDPVYQVDKGGRVRFVVELADPKLEVKWNKNGQELRPST-KYIFEDTRCQSI 307
Query: 985 XXXXX-XXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D D++ ST L+V+E ++L+D + LE E++ +
Sbjct: 308 LNIDNCQMTDDSEYYVTAGDEKCSTELLVREPPIMVTKQLEDTTDYCGERVELECEVSED 367
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
A V W ++GE I + +Y G L I + D +YS + +A+++V
Sbjct: 368 DAQVKWFKNGEEIILVQTRYRIRVEGKKHILIIEGATKADAADYSVMTTGGQSSAKLSVD 427
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
P +I+T L +Q VN G + + E+++ + +W K+G +Q S+ +++ G+ KL
Sbjct: 428 LKPLKILTPLTDQTVNLGKEICLKCEISE-NIPGKWTKNGLPVQESDRLKVVHKGRIHKL 486
Query: 1164 KIYDCDLDDAGEY--SCEVGNSKCTA-ILTVEEPSINFT-LRLPEFILVPANTDAYLTVE 1219
I +D G+Y + + N A + ++ P I L + V A L +
Sbjct: 487 VIDHALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIP 546
Query: 1220 IPDETLDVTWYKK--KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKS 1275
I E + + K+++E + + S TL+I DD Y L + ++
Sbjct: 547 ISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEA 606
Query: 1276 TTKLKVEVVEFP-PKIVDYEREYRIKRGSDVTLL-VDYQAFP--QPNDEWIVNSKIIKKC 1331
+KV+VV+FP P + E G D ++ + A+ P + + K +
Sbjct: 607 HASIKVKVVDFPDPPVAPTVTEV----GDDWCIMNWEPPAYDGGSPILGYFIERKKKQSS 662
Query: 1332 KHTKPSID-SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
+ + + D K + KK+ A ++ N G + M + P +L
Sbjct: 663 RWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLL 722
Query: 1391 EIDS---SSINICWDEPENTGNSTIIYYVVEY------------------QEIDTTEWIS 1429
+DS +++ + W P++ G + + YV+EY ++ +WI
Sbjct: 723 TVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGSTSAKQSDENGEAAYDLPAEDWIV 782
Query: 1430 VKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDA---SETTEYYKVIKETKIQSPTV 1484
I KT+ +I L T++ R AVN S+ S+ ++I+ KI SP
Sbjct: 783 ANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIHSPKH 842
Query: 1485 EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
K + + + L F G P+P++TW +DG ++ + N
Sbjct: 843 LK--QTYIRRVGDRVILVIPFQGKPRPELTWKKDGAEIDKNQINIRN 887
Score = 100 bits (240), Expect = 5e-20
Identities = 52/178 (29%), Positives = 97/178 (54%), Gaps = 6/178 (3%)
Query: 1576 SNEDIKQKH--KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
S + +KQ + +VGD ++ +G P PE+ W K+G +++ + + NI E ++I I+
Sbjct: 839 SPKHLKQTYIRRVGDRVILVIPFQGKPRPELTWKKDGAEIDKN-QINIRNSETDTIIFIR 897
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDD 1693
+ +RSHS KY ++ + + +++ D+P P+ V + ++ +V + W PP DD
Sbjct: 898 KAERSHSGKYDLQVKVDKFVETASIDIRIIDRPGPPQ-IVKIEDVWGRNVALTWTPPKDD 956
Query: 1694 GGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE 1751
G +T Y I+K + + W++V ++ +E +L EY FRV ++N G SE
Sbjct: 957 GNAAITGYTIQKADKKSMEWLRV--IEHIIEPVPHTELVIGNEYYFRVFSENMCGLSE 1012
Score = 87.4 bits (207), Expect = 5e-16
Identities = 60/228 (26%), Positives = 108/228 (47%), Gaps = 11/228 (4%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYT 1644
G++ + I G PPP+ +W + G+K + I T+ +S + I +R S Y
Sbjct: 538 GNKLRLEIPISGEPPPKAMWSR-GDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYH 596
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
I N AG + + +KV D P P P + E+ + + W+PP DGG + Y IE
Sbjct: 597 INLKNEAGEAHASIKVKVVDFPDPPVAPTVT-EVGDDWCIMNWEPPAYDGGSPILGYFIE 655
Query: 1705 KHEPDNNRWIKV-ADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKT 1762
+ + ++RW+++ D+ ++ T+ +K+ E Y R+ A N +G S+ ++ S P V
Sbjct: 656 RKKKQSSRWMRLNFDLCKET-TFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLA 714
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG 1810
P+ + + +V + W P + G + + Y +E EG
Sbjct: 715 VTSPPT----LLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEG 758
Score = 85.0 bits (201), Expect = 3e-15
Identities = 72/307 (23%), Positives = 134/307 (43%), Gaps = 22/307 (7%)
Query: 1282 EVVEFPPKIVD--YEREYRIKR-GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSI 1338
E++E PPKI + ++ I+R G V L++ +Q P+P W + I K + +
Sbjct: 830 EIIE-PPKIHSPKHLKQTYIRRVGDRVILVIPFQGKPRPELTWKKDGAEIDKNQINIRNS 888
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
++ + + I+K E + +G Y L+++ + +++ I+D+P PP I ++ ++
Sbjct: 889 ETDTI-IFIRKAERSHSGKYDLQVKVDKFVETASIDIRIIDRPGPPQIVKIEDVWGRNVA 947
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
+ W P++ GN+ I Y ++ + + EW+ V L + Y FR ++ N
Sbjct: 948 LTWTPPKDDGNAAITGYTIQKADKKSMEWLRVIEHIIEPVPHTELVIGNEYYFRVFSENM 1007
Query: 1459 VDIS-DASETTEYYKVIKETKI------------QSPTVEKPLKNITTEPNEDIELTCIF 1505
+S DA+ T E + ++ KI ++P +PL N L C
Sbjct: 1008 CGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNRLCHSGYMATLNCSV 1067
Query: 1506 GGVPQPKVTWYRDGKKL--KTAKATYENRX--XXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
G P+PK+TW ++ + + N Y C A ND G VE
Sbjct: 1068 RGNPKPKITWMKNKVAIVDDPRYRMFSNLGVCTLEIGKPSPYDGGTYCCKAVNDLGTVEI 1127
Query: 1562 SCVVGIQ 1568
C + ++
Sbjct: 1128 ECKLEVK 1134
Score = 67.7 bits (158), Expect = 4e-10
Identities = 40/132 (30%), Positives = 67/132 (50%), Gaps = 7/132 (5%)
Query: 1929 NIKEKDEI-IFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSW 1987
+I E+D+ ++ I+ +N G + S+++ K P PP AP + VG + + +W
Sbjct: 585 DIAERDDSGVYHINLKNEAGEA----HASIKV-KVVDFPDPPVAPT-VTEVGDDWCIMNW 638
Query: 1988 GTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P +DGG+P+LGY I + + WM + F + + E Y +RI+A N I
Sbjct: 639 EPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAI 698
Query: 2048 GLSEPLESDEPF 2059
G+S+P PF
Sbjct: 699 GISKPSMPSRPF 710
Score = 64.9 bits (151), Expect = 3e-09
Identities = 162/805 (20%), Positives = 279/805 (34%), Gaps = 87/805 (10%)
Query: 1192 EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKR 1251
E+ S F L V VE+ D L+V W K + + K+ + D + +
Sbjct: 247 EKKSAAFAKILDPVYQVDKGGRVRFVVELADPKLEVKWNKNGQELRPSTKY-IFEDTRCQ 305
Query: 1252 TLI-IRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD 1310
+++ I C D EY D K +T+L +V PP +V + E + L
Sbjct: 306 SILNIDNCQMTDDSEYYVTAGDEKCSTEL---LVREPPIMVTKQLEDTTDYCGERVELEC 362
Query: 1311 YQAFPQPNDEWIVNSK-IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
+ +W N + II + ++ K L I+ DA Y + A
Sbjct: 363 EVSEDDAQVKWFKNGEEIILVQTRYRIRVEGKKHILIIEGATKADAADYSVMTTGGQSSA 422
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
+ +++ L K P + + C G T V QE D + +
Sbjct: 423 KLSVDLKPL-KILTPLTDQTVNLGKEICLKCEISENIPGKWTKNGLPV--QESDRLKVVH 479
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
I K + Y F A N V + + K+I + TV
Sbjct: 480 KGRIHKLVIDHALTEDEGDYVFAPDAYN-VTLPAKVHVIDPPKIILDGLDADNTV----- 533
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA-----TYENRXXXXXXXXXXXX 1544
T + L G P PK W R K + +Y +
Sbjct: 534 --TVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDD 591
Query: 1545 XXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT----AVIEGIP 1600
Y N+ GE S V + P ++ +VGD+W + +G
Sbjct: 592 SGVYHINLKNEAGEAHASIKVKVVDFPDPPVA----PTVTEVGDDWCIMNWEPPAYDGGS 647
Query: 1601 PPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P ++ Y K + + + K + K++ + + I A N G S +
Sbjct: 648 P--ILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSM 705
Query: 1659 TLKVYDKPSKPEGPVIMR--EISRESVTIEWKPPLDDGGLELTKYAIE---------KHE 1707
+ + + P ++ ++ +VT+ W+PP G L Y +E K
Sbjct: 706 PSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGSTSAKQS 765
Query: 1708 PDNNR---------WIKVADVDR-DVETYCIQKLNENCEYMFRVIAQNPVGFSEA-LESE 1756
+N WI VA+ D D + I L + + RV A N G SE S+
Sbjct: 766 DENGEAAYDLPAEDWI-VANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQ 824
Query: 1757 PIVIKTALDVPSXXX----XXXXXXXIDNESVYITWFPSEKNGGSPIIDYK---VEIKQE 1809
PI++K ++ P + + + + F + P + +K EI +
Sbjct: 825 PILVKEIIEPPKIHSPKHLKQTYIRRVGDRVILVIPFQGKPR---PELTWKKDGAEIDKN 881
Query: 1810 GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQP 1869
+ R + S + Y ++ + T+ I I + + P P
Sbjct: 882 QINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVETA-------SIDI-RIIDRPGPP 933
Query: 1870 RNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIEN 1929
+ + + R+V L WT P+ +G + IT Y I+ K W +++ EH IE
Sbjct: 934 QIVKIEDVWGRNVALTWTPPKDDGNAAITGYTIQKADKKSMEWLRVI-------EHIIEP 986
Query: 1930 IKEKDEII-----FRISAENTVGVS 1949
+ + +I FR+ +EN G+S
Sbjct: 987 VPHTELVIGNEYYFRVFSENMCGLS 1011
Score = 58.4 bits (135), Expect = 3e-07
Identities = 66/245 (26%), Positives = 94/245 (38%), Gaps = 31/245 (12%)
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
+ I +NE G + + K+ + PP P V+E + W P +GGSP
Sbjct: 595 YHINLKNEAGEA---HASIKVKVVDFPDPPVAP---TVTEVGDDWCIMNWEPPAYDGGSP 648
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIF--RISAENTVGVSLPTES 1954
I Y IE K + W ++ E E K + + + RI A N +G+S P S
Sbjct: 649 ILGYFIERKKKQSSRWMRLNF--DLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKP--S 704
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI----------- 2003
R V SPPT L + V V W P+ G A L GY +
Sbjct: 705 MPSRPFVPLAVTSPPTL-LTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGSTSAK 763
Query: 2004 -------AIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESD 2056
A D+ W+ K ++ KF I L + +R+ A N G SEP
Sbjct: 764 QSDENGEAAYDLPAEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYS 823
Query: 2057 EPFKV 2061
+P V
Sbjct: 824 QPILV 828
Score = 56.0 bits (129), Expect = 1e-06
Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 4/111 (3%)
Query: 491 KIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAII 550
KI K PV+E + S AP+F + L + G C V G P+P+ITW + I
Sbjct: 1028 KIYKNPVYE---DFDFSEAPMFTQPLVNRLCHSGYMATLNCSVRGNPKPKITWMKNKVAI 1084
Query: 551 KPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
++M + + V TL I + P D GT+ C A N G +L V+
Sbjct: 1085 VDDPRYRM-FSNLGVCTLEIGKPSPYDGGTYCCKAVNDLGTVEIECKLEVK 1134
Score = 45.6 bits (103), Expect = 0.002
Identities = 30/94 (31%), Positives = 41/94 (43%), Gaps = 4/94 (4%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK---SDGDTHSI 789
E P +PL + + G L+ V GNP+P ITW KN + P S+ ++
Sbjct: 1042 EAPMFTQPLVNRLCHSGYMATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNLGVCTL 1101
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
I KP D G Y KA N G E + V+
Sbjct: 1102 EIGKPSPY-DGGTYCCKAVNDLGTVEIECKLEVK 1134
Score = 43.2 bits (97), Expect = 0.010
Identities = 28/101 (27%), Positives = 44/101 (43%), Gaps = 3/101 (2%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + G N+ +T W P+ DG A + GY I D W+ V + + +
Sbjct: 930 PGPPQIVKIEDVWGRNVALT-WTPPKDDGNAAITGYTIQKADKKSMEWLRVIEHIIEPVP 988
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEG 2066
+L + Y R+++ N GLSE + VI +G
Sbjct: 989 HT--ELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDG 1027
Score = 39.5 bits (88), Expect = 0.13
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 733 EPPQVIEP--LKSMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHS 788
EPP++ P LK +R+ G+ VIL G PRP +TW K+ + K + +T +
Sbjct: 833 EPPKIHSPKHLKQTYIRRVGDRVILVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDT 892
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
I ++ + G Y L+ + + ET+++
Sbjct: 893 IIFIRKAERSHSGKYDLQVK-VDKFVETASI 922
Score = 36.3 bits (80), Expect = 1.2
Identities = 45/189 (23%), Positives = 79/189 (41%), Gaps = 23/189 (12%)
Query: 643 QYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
Q V+ G +I L+C + IP W G + + + V + +H L I +
Sbjct: 440 QTVNLGKEICLKCEISENIPGK---WTKNGLPVQESDRLKVVHKGRIHK----LVIDHAL 492
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI----EPLKSMIVRQGESVILSAQ 757
EG Y V A + + + L K +PP++I + ++ V G + L
Sbjct: 493 TEDEGDY-VFAPD-----AYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIP 546
Query: 758 VVGNPRPTITWCKNNKPVK----ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
+ G P P W + +K + + T+S D+ ++ I ++ D GVY + +N G
Sbjct: 547 ISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAER-DDSGVYHINLKNEAGE 605
Query: 814 AETSAVITV 822
A S + V
Sbjct: 606 AHASIKVKV 614
Score = 34.7 bits (76), Expect = 3.7
Identities = 17/67 (25%), Positives = 29/67 (43%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ G P P++ W KN + +D Y + + + I + Y +A N GT
Sbjct: 1067 VRGNPKPKITWMKNKVAIVDDPRYRMFSNLGVCTLEIGKPSPYDGGTYCCKAVNDLGTVE 1126
Query: 1656 VEVTLKV 1662
+E L+V
Sbjct: 1127 IECKLEV 1133
>BC131529-1|AAI31530.1| 868|Homo sapiens eEF1A2 binding protein
protein.
Length = 868
Score = 157 bits (382), Expect = 3e-37
Identities = 106/473 (22%), Positives = 196/473 (41%), Gaps = 11/473 (2%)
Query: 1488 LKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXX 1547
L ++ +P E L+C P TW++DG KL T +
Sbjct: 79 LADMEVQPGEAATLSCTLTSDLGPG-TWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGT 137
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS-NEDIKQKH--KVGDEWLVTAVIEGIPPPEV 1604
G+ ++ + +Q P I E +++ K G +V + P +
Sbjct: 138 QAGRYTFVAGDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQA 197
Query: 1605 IWYKNGNKL--ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
W K+G ++ +D+E + + + + + R +Y++ + G+ E+TL+V
Sbjct: 198 AWRKDGAEVVGSSDREAQVDLGDGYTRLCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQV 257
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
DKP P+GP+ +++ R V + W+PP D+GG + Y +E+ + + W+KV + D
Sbjct: 258 IDKPDPPQGPMEVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPAD 317
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
T+ + +Y FRV A G EALESE I++ A + ++
Sbjct: 318 STTFTDAHVEPGRKYTFRVRAVTSEGAGEALESEEILV--APEALPKAPSAPAILSASSQ 375
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXAR--IQKLSINTTYQFRI 1839
+ +TW G + I+ Y +E +++G W R + + Y+FR+
Sbjct: 376 GITLTWTAPRGPGSAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRV 435
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A G P D + + PP RN V++ ++ S+TL W P++ G
Sbjct: 436 TAVAPSGPGEPGPPSDAVFARDPMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQG 495
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
Y++E + W V + + ++ + R++A N G S P+
Sbjct: 496 YVVELCSSDSLQWLPCHVGTVPVTTYTAKGLRPGEGYFVRVTAVNEGGQSQPS 548
Score = 98.7 bits (235), Expect = 2e-19
Identities = 150/686 (21%), Positives = 264/686 (38%), Gaps = 41/686 (5%)
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
L + +V G AT LT WFKDG ++ + + DG L I
Sbjct: 79 LADMEVQPGEAATLSCTLTSDLGPGTWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQ 138
Query: 1173 AGEYSCEVGNSKCTAILTVEE-PSI--NFTLRLPEFILVPANTDAYLTVEIPDET-LDVT 1228
AG Y+ G+ + A LTV++ P+I + T +L E ++V A + + +
Sbjct: 139 AGRYTFVAGDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQAA 198
Query: 1229 WYKKKSVI---EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEV 1283
W K + + D E + D R L + D +Y+ L + + L ++V
Sbjct: 199 WRKDGAEVVGSSDREAQVDLGDGYTR-LCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQV 257
Query: 1284 VEFP-PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS-IDSK 1341
++ P P E + + G + + + ++V + + K +
Sbjct: 258 IDKPDPPQGPMEVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPAD 317
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP----PGKPNILEIDSSSI 1397
S + T VE +++R + G + + IL P P P IL S I
Sbjct: 318 STTFTDAHVEPGRKYTFRVRAVTSEGAGEALESEEILVAPEALPKAPSAPAILSASSQGI 377
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYA 1455
+ W P G++ I+ Y++E ++ + W +V + + + + ++ +++ Y FR A
Sbjct: 378 TLTWTAPRGPGSAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTA 437
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF-----GGVPQ 1510
V + ++ V ++ P + + L+ +T N I L+ G Q
Sbjct: 438 VAPSGPGEPGPPSD--AVFARDPMRPPGLVRNLQ-VTDRSNTSITLSWAGPDTQEGDEAQ 494
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHGEVETSCVVGIQ 1568
V L+ Y + A N+ G+ + S + +
Sbjct: 495 GYVVELCSSDSLQWLPCHVGTVPVTTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLV 554
Query: 1569 QKPVITISNE---DIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
Q +T+ + D K KVGD V E +P PEV W K+G L K
Sbjct: 555 QAMPVTVCPKFLVDSSTKDLLTVKVGDTVRVPVSFEAMPMPEVTWLKDG--LPLPKRSVT 612
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS-SVEVTLKVYDKPSKPEGPVIMREISR 1680
TK+ + + I S S YT+ G + ++V P P GP+ ++E
Sbjct: 613 VTKDGLTQLLIPVAGLSDSGLYTVVLRTLQGKEVAHSFRIRVAACPQAP-GPIHLQENVP 671
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
+VT EW+P D+ YA+ + W + AD + + + EY FR
Sbjct: 672 GTVTAEWEPSPDEAQDVPLHYAVFTRSSAHGPWHEAAD-RIYTNRFTLLGILPGHEYHFR 730
Query: 1741 VIAQNPVGFSEALE-SEPIVIKTALD 1765
V+A+N +G S+ + S+P I D
Sbjct: 731 VVAKNELGASKPSDTSQPWCIPRQRD 756
Score = 90.6 bits (215), Expect = 5e-17
Identities = 101/474 (21%), Positives = 169/474 (35%), Gaps = 36/474 (7%)
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+K+G KL + I ++ + + +YT AG E TL V D
Sbjct: 105 WFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQAGRYTF----VAGDQQSEATLTVQDS 160
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK-----VADVD 1720
P+ P + ++ RE + ++ P+ + K + H P W K V D
Sbjct: 161 PTI--APDVTEKL-REPLVVKAGKPV------IVKIPFQSHLPIQAAWRKDGAEVVGSSD 211
Query: 1721 RDVETYCIQKLNENCEYMFRVIAQNPVG-FSEALESEPIVIKTAL-----DVPSXXXXXX 1774
R+ + C + G +S L SE ++ L D P
Sbjct: 212 REAQVDLGDGYTRLC---LPSAGRKDCGQYSVTLRSEGGSVQAELTLQVIDKPDPPQGPM 268
Query: 1775 XXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSINT 1833
V + W P NGG + Y VE +Q G+ W +
Sbjct: 269 EVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPADSTTFTDAHVEP 328
Query: 1834 --TYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPES 1891
Y FR+ A G S++ + + L P P + ++S+ +TL WT P
Sbjct: 329 GRKYTFRVRAVTSEGAGEALESEEILVAPEAL--PKAPSAPAILSASSQGITLTWTAPRG 386
Query: 1892 NGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLP 1951
G + I Y+IE + +WT + + ++++ + FR++A G P
Sbjct: 387 PGSAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTAVAPSGPGEP 446
Query: 1952 TESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKT 2011
+ P L++ + + SW P+ G GY + +
Sbjct: 447 GPPSDAVFARDPMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQGYVVELCSSDSL 506
Query: 2012 MWM--EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIP 2063
W+ VG V V T + + L Y +R+ A NE G S+P D + +P
Sbjct: 507 QWLPCHVGTVPVTT--YTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLVQAMP 558
Score = 78.2 bits (184), Expect = 3e-13
Identities = 97/435 (22%), Positives = 166/435 (38%), Gaps = 27/435 (6%)
Query: 1637 RSHSSKYTIEASNTAGTS--SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDG 1694
R ++ + S AG + S E+ + P P P I+ S + +T+ W P G
Sbjct: 330 RKYTFRVRAVTSEGAGEALESEEILVAPEALPKAPSAPAIL-SASSQGITLTWTAPRGPG 388
Query: 1695 GLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE 1754
+ Y IE+ + +N W V D + + + + C+Y FRV A P G E
Sbjct: 389 SAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTAVAPSGPGEPGP 448
Query: 1755 SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI-KQEGKKW 1813
V P N S+ ++W + G Y VE+ + +W
Sbjct: 449 PSDAVFARDPMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQGYVVELCSSDSLQW 508
Query: 1814 K--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
+ L Y R+ A NE G S P D T+ + + P+
Sbjct: 509 LPCHVGTVPVTTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALD---TLVQAMPVTVCPK- 564
Query: 1872 FVVSESTSRSVTLKWTE----PESNGGSPI--TNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
F+V ST +T+K + P S P+ ++ + + +S T VT G + +
Sbjct: 565 FLVDSSTKDLLTVKVGDTVRVPVSFEAMPMPEVTWLKDGLPLPKRSVT--VTKDG-LTQL 621
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMT 1985
I D ++ + G + + S R+ + A P P P+ ++ V
Sbjct: 622 LIPVAGLSDSGLYTVVLRTLQGKEV---AHSFRI-RVAACPQAP-GPIHLQENVPGTVTA 676
Query: 1986 SWG-TPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
W +P+ PL Y + R W E + T +F + + H Y R+ A+
Sbjct: 677 EWEPSPDEAQDVPL-HYAVFTRSSAHGPWHEAAD-RIYTNRFTLLGILPGHEYHFRVVAK 734
Query: 2045 NEIGLSEPLESDEPF 2059
NE+G S+P ++ +P+
Sbjct: 735 NELGASKPSDTSQPW 749
Score = 70.5 bits (165), Expect = 6e-11
Identities = 67/326 (20%), Positives = 120/326 (36%), Gaps = 8/326 (2%)
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPA 1210
H+ GK +L IY D + + + P +F+ L + + P
Sbjct: 28 HLGSRRSGKDGRLDIYGERRDATRSSTSRYKPGTGSFSKDAQGPMGHFSQGLADMEVQPG 87
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
A L+ + + TW+K + + D +L I YT V
Sbjct: 88 EA-ATLSCTLTSDLGPGTWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQAGRYTFVA 146
Query: 1271 LDAKSTTKLKVE-VVEFPPKIVDYERE-YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
D +S L V+ P + + RE +K G V + + +Q+ W + +
Sbjct: 147 GDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQAAWRKDGAEV 206
Query: 1329 KKCKHTKPSIDSKSA--SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-G 1385
+ +D L + D G Y + L + G E+ + ++DKP PP G
Sbjct: 207 VGSSDREAQVDLGDGYTRLCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQVIDKPDPPQG 266
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSI--QNL 1443
+ + + + + W P + G T+ YVVE ++ + W+ V T+ ++
Sbjct: 267 PMEVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPADSTTFTDAHV 326
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTE 1469
+ Y FR AV +A E+ E
Sbjct: 327 EPGRKYTFRVRAVTSEGAGEALESEE 352
Score = 62.9 bits (146), Expect = 1e-08
Identities = 39/111 (35%), Positives = 55/111 (49%), Gaps = 6/111 (5%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
K P + +P + S P F+ LR P G C V+G PRP +TWF+ ++ +
Sbjct: 761 KAPCYREP---DLSQKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGN 817
Query: 554 QDFQMYYDD-DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+Y D V +L I V P+D+G + VA+N G A ST LIV P
Sbjct: 818 P--AVYSTDLLGVCSLTIPSVSPKDSGEYKAVAENTLGQAVSTATLIVIEP 866
Score = 56.4 bits (130), Expect = 1e-06
Identities = 32/96 (33%), Positives = 51/96 (53%), Gaps = 2/96 (2%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITIL 792
+ P+ + L+S ++ QG +S V G+PRP +TW KN++ ++ P D + L
Sbjct: 772 QKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSL 831
Query: 793 KPKKV--KDEGVYTLKAENSEGIAETSAVITVEEPT 826
V KD G Y AEN+ G A ++A + V EP+
Sbjct: 832 TIPSVSPKDSGEYKAVAENTLGQAVSTATLIVIEPS 867
Score = 53.2 bits (122), Expect = 1e-05
Identities = 48/247 (19%), Positives = 98/247 (39%), Gaps = 18/247 (7%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
+K G V + V ++A P P W+ + + K T L I +D+G+Y
Sbjct: 577 VKVGDTVRVPVSFEAMPMPEVTWLKDGLPLPKRSVTVTK--DGLTQLLIPVAGLSDSGLY 634
Query: 1359 KLRLENNCG-HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
+ L G + + P PG ++ E ++ W+ + ++Y V
Sbjct: 635 TVVLRTLQGKEVAHSFRIRVAACPQAPGPIHLQENVPGTVTAEWEPSPDEAQDVPLHYAV 694
Query: 1418 EYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ W + I + ++ + Y FR A NE+ S S+T++ + + ++
Sbjct: 695 FTRSSAHGPWHEAADRIYTNRFTLLGILPGHEYHFRVVAKNELGASKPSDTSQPWCIPRQ 754
Query: 1477 T---KIQSPTVEKP-----------LKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+++P +P L++ + ++C G P+P VTW+++ + L
Sbjct: 755 RDRFTVKAPCYREPDLSQKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSL 814
Query: 1523 KTAKATY 1529
+ A Y
Sbjct: 815 EGNPAVY 821
Score = 49.2 bits (112), Expect = 2e-04
Identities = 40/167 (23%), Positives = 73/167 (43%), Gaps = 10/167 (5%)
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRN 1078
F + L D EV+ + A L + S+ W +DG + + F++ G + L+I +
Sbjct: 75 FSQGLADMEVQPGEAATLSCTLTSDLGPGTWFKDGVKLTTQDGVI-FKQDGLVHSLFITH 133
Query: 1079 TSVHDEGEYSCILRDESCTAEVTVVELP---PEIITRLQNQKVNKGNKATFEIELTKGDA 1135
G Y+ + D+ A +TV + P P++ +L+ V K K +++
Sbjct: 134 VQGTQAGRYTFVAGDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVI-VKIPFQSH 192
Query: 1136 L---VRWFKDGSEIQFSN--HIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
L W KDG+E+ S+ Q+ + +L + D G+YS
Sbjct: 193 LPIQAAWRKDGAEVVGSSDREAQVDLGDGYTRLCLPSAGRKDCGQYS 239
Score = 39.5 bits (88), Expect = 0.13
Identities = 22/78 (28%), Positives = 33/78 (42%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G E ++ ++G P P V W+KN LE + T + I + S +Y
Sbjct: 788 GCECCMSCAVQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSLTIPSVSPKDSGEYKAV 847
Query: 1647 ASNTAGTSSVEVTLKVYD 1664
A NT G + TL V +
Sbjct: 848 AENTLGQAVSTATLIVIE 865
Score = 38.3 bits (85), Expect = 0.30
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 7/128 (5%)
Query: 800 EGVYT-LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE--ITVKEKGTIKLVARV 856
EG + + A N G ++ SA+ T+ + P ++ + +TVK T+++
Sbjct: 530 EGYFVRVTAVNEGGQSQPSALDTLVQAMPVTVCPKFLVDSSTKDLLTVKVGDTVRVPVSF 589
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS- 915
P+P +TW ++ + P ++T DG + ++ V DSG Y V GK
Sbjct: 590 EAMPMPEVTWLKDG-LPLPKRSVTVTKDG--LTQLLIPVAGLSDSGLYTVVLRTLQGKEV 646
Query: 916 SHGARVTI 923
+H R+ +
Sbjct: 647 AHSFRIRV 654
Score = 35.9 bits (79), Expect = 1.6
Identities = 19/68 (27%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 856 VTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS 915
V +P P +TW++N+ + + + L I +V + DSG+YK VA N+ G++
Sbjct: 797 VQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSLTIPSVSPK-DSGEYKAVAENTLGQA 855
Query: 916 SHGARVTI 923
A + +
Sbjct: 856 VSTATLIV 863
Score = 34.7 bits (76), Expect = 3.7
Identities = 25/95 (26%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
P+ + R + + +G + + Q P+P+ W N + ++ + SLTI
Sbjct: 774 PRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSLTI 833
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
V D+G YK EN G A V I+ +PS
Sbjct: 834 PSVSPKDSGEYKAVAENTLGQA-VSTATLIVIEPS 867
Score = 34.7 bits (76), Expect = 3.7
Identities = 23/86 (26%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F ++ + +G + + C + P P + W FK + + E +D+ CS
Sbjct: 774 PRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTW-FKNDRSL--EGNPAVYSTDLLGVCS 830
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEA 719
L I +V G Y VA N G+A
Sbjct: 831 -LTIPSVSPKDSGEYKAVAENTLGQA 855
>AY245430-1|AAO92932.1| 868|Homo sapiens eEF1A2 binding protein
protein.
Length = 868
Score = 157 bits (382), Expect = 3e-37
Identities = 106/473 (22%), Positives = 196/473 (41%), Gaps = 11/473 (2%)
Query: 1488 LKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXX 1547
L ++ +P E L+C P TW++DG KL T +
Sbjct: 79 LADMEVQPGEAATLSCTLTSDLGPG-TWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGT 137
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITIS-NEDIKQKH--KVGDEWLVTAVIEGIPPPEV 1604
G+ ++ + +Q P I E +++ K G +V + P +
Sbjct: 138 QAGRYTFVAGDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQA 197
Query: 1605 IWYKNGNKL--ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
W K+G ++ +D+E + + + + + R +Y++ + G+ E+TL+V
Sbjct: 198 AWRKDGAEVVGSSDREAQVDLGDGYTRLCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQV 257
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
DKP P+GP+ +++ R V + W+PP D+GG + Y +E+ + + W+KV + D
Sbjct: 258 IDKPDPPQGPMEVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPAD 317
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
T+ + +Y FRV A G EALESE I++ A + ++
Sbjct: 318 STTFTDAHVEPGRKYTFRVRAVTSEGAGEALESEEILV--APEALPKAPSAPAILSASSQ 375
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXAR--IQKLSINTTYQFRI 1839
+ +TW G + I+ Y +E +++G W R + + Y+FR+
Sbjct: 376 GITLTWTAPRGPGSAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRV 435
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A G P D + + PP RN V++ ++ S+TL W P++ G
Sbjct: 436 TAVAPSGPGEPGPPSDAVFARDPMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQG 495
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
Y++E + W V + + ++ + R++A N G S P+
Sbjct: 496 YVVELCSSDSLQWLPCHVGTVPVTTYTAKGLRPGEGYFVRVTAVNEGGQSQPS 548
Score = 98.7 bits (235), Expect = 2e-19
Identities = 150/686 (21%), Positives = 264/686 (38%), Gaps = 41/686 (5%)
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
L + +V G AT LT WFKDG ++ + + DG L I
Sbjct: 79 LADMEVQPGEAATLSCTLTSDLGPGTWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQ 138
Query: 1173 AGEYSCEVGNSKCTAILTVEE-PSI--NFTLRLPEFILVPANTDAYLTVEIPDET-LDVT 1228
AG Y+ G+ + A LTV++ P+I + T +L E ++V A + + +
Sbjct: 139 AGRYTFVAGDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQAA 198
Query: 1229 WYKKKSVI---EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEV 1283
W K + + D E + D R L + D +Y+ L + + L ++V
Sbjct: 199 WRKDGAEVVGSSDREAQVDLGDGYTR-LCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQV 257
Query: 1284 VEFP-PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS-IDSK 1341
++ P P E + + G + + + ++V + + K +
Sbjct: 258 IDKPDPPQGPMEVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPAD 317
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP----PGKPNILEIDSSSI 1397
S + T VE +++R + G + + IL P P P IL S I
Sbjct: 318 STTFTDAHVEPGRKYTFRVRAVTSEGAGEALESEEILVAPEALPKAPSAPAILSASSQGI 377
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYA 1455
+ W P G++ I+ Y++E ++ + W +V + + + + ++ +++ Y FR A
Sbjct: 378 TLTWTAPRGPGSAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTA 437
Query: 1456 VNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIF-----GGVPQ 1510
V + ++ V ++ P + + L+ +T N I L+ G Q
Sbjct: 438 VAPSGPGEPGPPSD--AVFARDPMRPPGLVRNLQ-VTDRSNTSITLSWAGPDTQEGDEAQ 494
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHGEVETSCVVGIQ 1568
V L+ Y + A N+ G+ + S + +
Sbjct: 495 GYVVELCSSDSLQWLPCHVGTVPVTTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLV 554
Query: 1569 QKPVITISNE---DIKQKH----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
Q +T+ + D K KVGD V E +P PEV W K+G L K
Sbjct: 555 QAMPVTVCPKFLVDSSTKDLLTVKVGDTVRVPVSFEAMPMPEVTWLKDG--LPLPKRSVT 612
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS-SVEVTLKVYDKPSKPEGPVIMREISR 1680
TK+ + + I S S YT+ G + ++V P P GP+ ++E
Sbjct: 613 VTKDGLTQLLIPVAGLSDSGLYTVVLRTLQGKEVAHSFRIRVAACPQAP-GPIHLQENVP 671
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
+VT EW+P D+ YA+ + W + AD + + + EY FR
Sbjct: 672 GTVTAEWEPSPDEAQDVPLHYAVFTRSSAHGPWHEAAD-RIYTNRFTLLGILPGHEYHFR 730
Query: 1741 VIAQNPVGFSEALE-SEPIVIKTALD 1765
V+A+N +G S+ + S+P I D
Sbjct: 731 VVAKNELGASKPSDTSQPWCIPRQRD 756
Score = 90.6 bits (215), Expect = 5e-17
Identities = 101/474 (21%), Positives = 169/474 (35%), Gaps = 36/474 (7%)
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+K+G KL + I ++ + + +YT AG E TL V D
Sbjct: 105 WFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQAGRYTF----VAGDQQSEATLTVQDS 160
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK-----VADVD 1720
P+ P + ++ RE + ++ P+ + K + H P W K V D
Sbjct: 161 PTI--APDVTEKL-REPLVVKAGKPV------IVKIPFQSHLPIQAAWRKDGAEVVGSSD 211
Query: 1721 RDVETYCIQKLNENCEYMFRVIAQNPVG-FSEALESEPIVIKTAL-----DVPSXXXXXX 1774
R+ + C + G +S L SE ++ L D P
Sbjct: 212 REAQVDLGDGYTRLC---LPSAGRKDCGQYSVTLRSEGGSVQAELTLQVIDKPDPPQGPM 268
Query: 1775 XXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSINT 1833
V + W P NGG + Y VE +Q G+ W +
Sbjct: 269 EVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPADSTTFTDAHVEP 328
Query: 1834 --TYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPES 1891
Y FR+ A G S++ + + L P P + ++S+ +TL WT P
Sbjct: 329 GRKYTFRVRAVTSEGAGEALESEEILVAPEAL--PKAPSAPAILSASSQGITLTWTAPRG 386
Query: 1892 NGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLP 1951
G + I Y+IE + +WT + + ++++ + FR++A G P
Sbjct: 387 PGSAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTAVAPSGPGEP 446
Query: 1952 TESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKT 2011
+ P L++ + + SW P+ G GY + +
Sbjct: 447 GPPSDAVFARDPMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQGYVVELCSSDSL 506
Query: 2012 MWM--EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIP 2063
W+ VG V V T + + L Y +R+ A NE G S+P D + +P
Sbjct: 507 QWLPCHVGTVPVTT--YTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLVQAMP 558
Score = 78.2 bits (184), Expect = 3e-13
Identities = 97/435 (22%), Positives = 166/435 (38%), Gaps = 27/435 (6%)
Query: 1637 RSHSSKYTIEASNTAGTS--SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDG 1694
R ++ + S AG + S E+ + P P P I+ S + +T+ W P G
Sbjct: 330 RKYTFRVRAVTSEGAGEALESEEILVAPEALPKAPSAPAIL-SASSQGITLTWTAPRGPG 388
Query: 1695 GLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE 1754
+ Y IE+ + +N W V D + + + + C+Y FRV A P G E
Sbjct: 389 SAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTAVAPSGPGEPGP 448
Query: 1755 SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI-KQEGKKW 1813
V P N S+ ++W + G Y VE+ + +W
Sbjct: 449 PSDAVFARDPMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQGYVVELCSSDSLQW 508
Query: 1814 K--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
+ L Y R+ A NE G S P D T+ + + P+
Sbjct: 509 LPCHVGTVPVTTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALD---TLVQAMPVTVCPK- 564
Query: 1872 FVVSESTSRSVTLKWTE----PESNGGSPI--TNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
F+V ST +T+K + P S P+ ++ + + +S T VT G + +
Sbjct: 565 FLVDSSTKDLLTVKVGDTVRVPVSFEAMPMPEVTWLKDGLPLPKRSVT--VTKDG-LTQL 621
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMT 1985
I D ++ + G + + S R+ + A P P P+ ++ V
Sbjct: 622 LIPVAGLSDSGLYTVVLRTLQGKEV---AHSFRI-RVAACPQAP-GPIHLQENVPGTVTA 676
Query: 1986 SWG-TPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
W +P+ PL Y + R W E + T +F + + H Y R+ A+
Sbjct: 677 EWEPSPDEAQDVPL-HYAVFTRSSAHGPWHEAAD-RIYTNRFTLLGILPGHEYHFRVVAK 734
Query: 2045 NEIGLSEPLESDEPF 2059
NE+G S+P ++ +P+
Sbjct: 735 NELGASKPSDTSQPW 749
Score = 70.5 bits (165), Expect = 6e-11
Identities = 67/326 (20%), Positives = 120/326 (36%), Gaps = 8/326 (2%)
Query: 1151 HIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPA 1210
H+ GK +L IY D + + + P +F+ L + + P
Sbjct: 28 HLGSRRSGKDGRLDIYGERRDATRSSTSRYKPGTGSFSKDAQGPMGHFSQGLADMEVQPG 87
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
A L+ + + TW+K + + D +L I YT V
Sbjct: 88 EA-ATLSCTLTSDLGPGTWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQAGRYTFVA 146
Query: 1271 LDAKSTTKLKVE-VVEFPPKIVDYERE-YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
D +S L V+ P + + RE +K G V + + +Q+ W + +
Sbjct: 147 GDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQAAWRKDGAEV 206
Query: 1329 KKCKHTKPSIDSKSA--SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-G 1385
+ +D L + D G Y + L + G E+ + ++DKP PP G
Sbjct: 207 VGSSDREAQVDLGDGYTRLCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQVIDKPDPPQG 266
Query: 1386 KPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSI--QNL 1443
+ + + + + W P + G T+ YVVE ++ + W+ V T+ ++
Sbjct: 267 PMEVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPADSTTFTDAHV 326
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTE 1469
+ Y FR AV +A E+ E
Sbjct: 327 EPGRKYTFRVRAVTSEGAGEALESEE 352
Score = 62.9 bits (146), Expect = 1e-08
Identities = 39/111 (35%), Positives = 55/111 (49%), Gaps = 6/111 (5%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
K P + +P + S P F+ LR P G C V+G PRP +TWF+ ++ +
Sbjct: 761 KAPCYREP---DLSQKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGN 817
Query: 554 QDFQMYYDD-DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+Y D V +L I V P+D+G + VA+N G A ST LIV P
Sbjct: 818 P--AVYSTDLLGVCSLTIPSVSPKDSGEYKAVAENTLGQAVSTATLIVIEP 866
Score = 56.4 bits (130), Expect = 1e-06
Identities = 32/96 (33%), Positives = 51/96 (53%), Gaps = 2/96 (2%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITIL 792
+ P+ + L+S ++ QG +S V G+PRP +TW KN++ ++ P D + L
Sbjct: 772 QKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSL 831
Query: 793 KPKKV--KDEGVYTLKAENSEGIAETSAVITVEEPT 826
V KD G Y AEN+ G A ++A + V EP+
Sbjct: 832 TIPSVSPKDSGEYKAVAENTLGQAVSTATLIVIEPS 867
Score = 53.2 bits (122), Expect = 1e-05
Identities = 48/247 (19%), Positives = 98/247 (39%), Gaps = 18/247 (7%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
+K G V + V ++A P P W+ + + K T L I +D+G+Y
Sbjct: 577 VKVGDTVRVPVSFEAMPMPEVTWLKDGLPLPKRSVTVTK--DGLTQLLIPVAGLSDSGLY 634
Query: 1359 KLRLENNCG-HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
+ L G + + P PG ++ E ++ W+ + ++Y V
Sbjct: 635 TVVLRTLQGKEVAHSFRIRVAACPQAPGPIHLQENVPGTVTAEWEPSPDEAQDVPLHYAV 694
Query: 1418 EYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ W + I + ++ + Y FR A NE+ S S+T++ + + ++
Sbjct: 695 FTRSSAHGPWHEAADRIYTNRFTLLGILPGHEYHFRVVAKNELGASKPSDTSQPWCIPRQ 754
Query: 1477 T---KIQSPTVEKP-----------LKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+++P +P L++ + ++C G P+P VTW+++ + L
Sbjct: 755 RDRFTVKAPCYREPDLSQKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSL 814
Query: 1523 KTAKATY 1529
+ A Y
Sbjct: 815 EGNPAVY 821
Score = 49.2 bits (112), Expect = 2e-04
Identities = 40/167 (23%), Positives = 73/167 (43%), Gaps = 10/167 (5%)
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRN 1078
F + L D EV+ + A L + S+ W +DG + + F++ G + L+I +
Sbjct: 75 FSQGLADMEVQPGEAATLSCTLTSDLGPGTWFKDGVKLTTQDGVI-FKQDGLVHSLFITH 133
Query: 1079 TSVHDEGEYSCILRDESCTAEVTVVELP---PEIITRLQNQKVNKGNKATFEIELTKGDA 1135
G Y+ + D+ A +TV + P P++ +L+ V K K +++
Sbjct: 134 VQGTQAGRYTFVAGDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVI-VKIPFQSH 192
Query: 1136 L---VRWFKDGSEIQFSN--HIQLTIDGKKQKLKIYDCDLDDAGEYS 1177
L W KDG+E+ S+ Q+ + +L + D G+YS
Sbjct: 193 LPIQAAWRKDGAEVVGSSDREAQVDLGDGYTRLCLPSAGRKDCGQYS 239
Score = 39.5 bits (88), Expect = 0.13
Identities = 22/78 (28%), Positives = 33/78 (42%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G E ++ ++G P P V W+KN LE + T + I + S +Y
Sbjct: 788 GCECCMSCAVQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSLTIPSVSPKDSGEYKAV 847
Query: 1647 ASNTAGTSSVEVTLKVYD 1664
A NT G + TL V +
Sbjct: 848 AENTLGQAVSTATLIVIE 865
Score = 38.3 bits (85), Expect = 0.30
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 7/128 (5%)
Query: 800 EGVYT-LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE--ITVKEKGTIKLVARV 856
EG + + A N G ++ SA+ T+ + P ++ + +TVK T+++
Sbjct: 530 EGYFVRVTAVNEGGQSQPSALDTLVQAMPVTVCPKFLVDSSTKDLLTVKVGDTVRVPVSF 589
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS- 915
P+P +TW ++ + P ++T DG + ++ V DSG Y V GK
Sbjct: 590 EAMPMPEVTWLKDG-LPLPKRSVTVTKDG--LTQLLIPVAGLSDSGLYTVVLRTLQGKEV 646
Query: 916 SHGARVTI 923
+H R+ +
Sbjct: 647 AHSFRIRV 654
Score = 35.9 bits (79), Expect = 1.6
Identities = 19/68 (27%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 856 VTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS 915
V +P P +TW++N+ + + + L I +V + DSG+YK VA N+ G++
Sbjct: 797 VQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSLTIPSVSPK-DSGEYKAVAENTLGQA 855
Query: 916 SHGARVTI 923
A + +
Sbjct: 856 VSTATLIV 863
Score = 34.7 bits (76), Expect = 3.7
Identities = 25/95 (26%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
P+ + R + + +G + + Q P+P+ W N + ++ + SLTI
Sbjct: 774 PRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSLTI 833
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
V D+G YK EN G A V I+ +PS
Sbjct: 834 PSVSPKDSGEYKAVAENTLGQA-VSTATLIVIEPS 867
Score = 34.7 bits (76), Expect = 3.7
Identities = 23/86 (26%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F ++ + +G + + C + P P + W FK + + E +D+ CS
Sbjct: 774 PRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTW-FKNDRSL--EGNPAVYSTDLLGVCS 830
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEA 719
L I +V G Y VA N G+A
Sbjct: 831 -LTIPSVSPKDSGEYKAVAENTLGQA 855
>AL834139-1|CAD38854.1| 1340|Homo sapiens hypothetical protein
protein.
Length = 1340
Score = 150 bits (364), Expect = 5e-35
Identities = 228/992 (22%), Positives = 393/992 (39%), Gaps = 92/992 (9%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLK--SMIVRQGESV 752
L++ V GTY+ VAV+ GEA L + EPP + + + + + G +
Sbjct: 369 LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM----EPPHIEDSGQPTELSLTPGAPM 424
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK--KVKDEGVYTLKAENS 810
L G P+P ITW K+ + + T+ + ++ + +L+ + +V+D G+YT AE+
Sbjct: 425 ELLCDAQGTPQPNITWHKDGQAL----TRLENNSRATRVLRVENVQVRDAGLYTCLAESP 480
Query: 811 EGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
G E S + V+ P N P RF + G + L V P P ITW+R+
Sbjct: 481 AGAIEKSFRVRVQAPP--NIVGPRG-PRF--VVGLAPGQLVLECSVEAEPAPKITWHRDG 535
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
I+ + TQ F L + + S DSGDY C A N+AG +S RV ++ V
Sbjct: 536 -IVLQEDAHTQ-FPERGRFLQLQAL-STADSGDYSCTARNAAGSTSVAFRV--EIHTVPT 590
Query: 931 VKHLQKSYETEEGKTVILECQTSHTVS--TKWYHNKKEISGMDHR-EIIQEGRXXXXXXX 987
++ + +T +L CQ + W ++ + R EI+ EG
Sbjct: 591 IRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG---SLRIQ 647
Query: 988 XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETAD 1046
D G C+ + S R+ +D V +A+L E + S
Sbjct: 648 PVLAQDAGHYLCLASNSAGSD------------RQGRDLRV----LALLPCEASGSPKPL 691
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVV 1103
VVW +DG+ + + + + L + D ++ C++ +E A V
Sbjct: 692 VVWWKDGQKLDFRLQQGAYRLLPS-NALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTV 750
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEI-QFSNHIQLTIDGKKQ 1161
+PP I + V T A V W K G+++ + +++ G
Sbjct: 751 HVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSG--- 807
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTA----ILTVEEPSINFTLRLPEFILVPANTDAYLT 1217
L+I AG Y+C NS A LTV+ + LP + A + L
Sbjct: 808 ALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV--VKPLPSVVRAVAEEEVLLP 865
Query: 1218 VE---IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E IP T +TW K+ + ++ + R I + +D Y C+ ++
Sbjct: 866 CEASGIPRPT--ITWQKEGLNVATGVSTQVLPGGQLR---IAHASPEDAGNYLCIAKNSA 920
Query: 1275 STTKLKVE-VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH 1333
+ K VV+ PP I + + GS L + P+PN W + + + +
Sbjct: 921 GSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAE- 979
Query: 1334 TKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEID 1393
K +I S L +K +E DAG Y EN G A +++TIL P P +
Sbjct: 980 GKFTI-QPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLR 1038
Query: 1394 SSSINICWDEPENTGNST-IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFR 1452
+ W G+ T I + V + + TE +S ++ T + S +
Sbjct: 1039 LG--DRLWLRCAARGSPTPRIGWTVNDRPV--TEGVSEQDGGSTLQRAA-VSREDSGTYV 1093
Query: 1453 AYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP-NEDIELTCIFGGVPQP 1511
+A N V + A + +KE +P ++ + EP I+L C+ G P P
Sbjct: 1094 CWAENRVGRTQAVS----FVHVKE----APVLQGEAFSYLVEPVGGSIQLDCVVRGDPVP 1145
Query: 1512 KVTWYRDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
+ W +DG L+ + ++ Y+C+A N+ G + ++ +Q
Sbjct: 1146 DIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSA 1205
Query: 1571 PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVI 1630
PV + +D+ + GD+ + G P P + W + G L + + T S +
Sbjct: 1206 PVFQVEPQDMTVRS--GDDVALRCQATGEPTPTIEWLQAGQPLRASR--RLRTLPDGS-L 1260
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ ++ + Y A N G+++ L V
Sbjct: 1261 WLENVETGDAGTYDCVAHNLLGSATARAFLVV 1292
Score = 105 bits (253), Expect = 1e-21
Identities = 128/565 (22%), Positives = 222/565 (39%), Gaps = 51/565 (9%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PPT + V + ++L C IP P ++W G ++ + S
Sbjct: 752 VPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPS----- 806
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
L+I G YT A N G A + L ++ V++PL S++ E
Sbjct: 807 -GALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP-----VVKPLPSVVRAVAEE 860
Query: 752 -VILSAQVVGNPRPTITWCKNNKPV-KALPTK-SDGDTHSITILKPKKVKDEGVYTLKAE 808
V+L + G PRPTITW K V + T+ G I P +D G Y A+
Sbjct: 861 EVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASP---EDAGNYLCIAK 917
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
NS G A + V+ PP+ N +++ E L + +P P+ITW +
Sbjct: 918 NSAGSAMGKTRLVVQ-------VPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDK 970
Query: 869 NNEIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ + +S +E T G EL++ N++ + D+G Y C A N+ G++ +TI V
Sbjct: 971 DGQPVSGAEGKFTIQPSG---ELLVKNLEGQ-DAGTYTCTAENAVGRARRRVHLTILVLP 1026
Query: 928 VTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
V +S + + + S T W N + ++ + ++
Sbjct: 1027 VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQRA 1082
Query: 988 XXXXXDVGVIKCIVKDQETSTMLV----VKETIPEFIRKLQDFEVKEKDVAI-LEVEINS 1042
D G C +++ T V VKE P + + V+ +I L+ +
Sbjct: 1083 AVSREDSGTYVCWAENRVGRTQAVSFVHVKEA-PVLQGEAFSYLVEPVGGSIQLDCVVRG 1141
Query: 1043 E-TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE-- 1099
+ D+ W +DG ++ ++ + L I T D G Y C+ +E A+
Sbjct: 1142 DPVPDIHWIKDGLPLRGSHLRHQLQN----GSLTIHRTERDDAGRYQCLAENEMGVAKKV 1197
Query: 1100 -VTVVELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTID 1157
+ V++ P Q+ V G+ + T + + W + G ++ S ++ D
Sbjct: 1198 VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD 1257
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGN 1182
G L + + + DAG Y C N
Sbjct: 1258 G---SLWLENVETGDAGTYDCVAHN 1279
Score = 98.7 bits (235), Expect = 2e-19
Identities = 102/463 (22%), Positives = 183/463 (39%), Gaps = 41/463 (8%)
Query: 650 DILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYT 709
++LL C IP P I W +G N++ + + + + L+I + G Y
Sbjct: 861 EVLLPCEASGIPRPTITWQKEGL------NVATGVSTQV-LPGGQLRIAHASPEDAGNYL 913
Query: 710 VVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWC 769
+A N G A L ++ PP + L + +G L + G+P P ITW
Sbjct: 914 CIAKNSAGSAMGKTRLVVQV----PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWD 969
Query: 770 KNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
K+ +PV K ++K + +D G YT AEN+ G A +T+
Sbjct: 970 KDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI------- 1022
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE 889
P+F + +++ + L +P P I W N+ + +E +++ G ++
Sbjct: 1023 LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPV--TEGVSEQDGGSTLQ 1080
Query: 890 LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE-GKTVIL 948
S DSG Y C A N G++ A + V++ ++ SY E G ++ L
Sbjct: 1081 RAAV---SREDSGTYVCWAENRVGRTQ--AVSFVHVKEAPVLQGEAFSYLVEPVGGSIQL 1135
Query: 949 EC--QTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ-- 1004
+C + W + + G R +Q G D G +C+ +++
Sbjct: 1136 DCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNG---SLTIHRTERDDAGRYQCLAENEMG 1192
Query: 1005 -ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNK 1062
+++V ++ P F + QD V+ D L + E T + W + G+ ++ +
Sbjct: 1193 VAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRL 1252
Query: 1063 YDFEKRGHIRKLYIRNTSVHDEGEYSCILRD--ESCTAEVTVV 1103
L++ N D G Y C+ + S TA +V
Sbjct: 1253 RTLPD----GSLWLENVETGDAGTYDCVAHNLLGSATARAFLV 1291
Score = 86.2 bits (204), Expect = 1e-15
Identities = 75/290 (25%), Positives = 122/290 (42%), Gaps = 23/290 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F+ P + + G + L C P P I W + E +S E D S
Sbjct: 1026 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT--EGVS---EQDGG---S 1077
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
L+ V + GTY A NR G + +K + P E ++ G S+
Sbjct: 1078 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK---EAPVLQGEAFSYLVEPVGGSIQ 1134
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI 813
L V G+P P I W K+ P++ + S+TI + ++ D G Y AEN G+
Sbjct: 1135 LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTER-DDAGRYQCLAENEMGV 1193
Query: 814 AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII 873
A+ ++ ++ EP Q++TV+ + L + T P P+I W + + +
Sbjct: 1194 AKKVVILVLQSAPVFQVEP-------QDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 1246
Query: 874 SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
S + DG L + NV++ D+G Y CVA N G ++ A + +
Sbjct: 1247 RASRRLRTLPDGS---LWLENVETG-DAGTYDCVAHNLLGSATARAFLVV 1292
Score = 82.6 bits (195), Expect = 1e-14
Identities = 131/641 (20%), Positives = 229/641 (35%), Gaps = 50/641 (7%)
Query: 1035 ILEVEINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+LE + +E A + W RDG +++ + F +RG R L ++ S D G+YSC R+
Sbjct: 516 VLECSVEAEPAPKITWHRDGIVLQEDAHT-QFPERG--RFLQLQALSTADSGDYSCTARN 572
Query: 1094 ESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQ-F 1148
+ + V + P I + V+ A + A LV W KD +
Sbjct: 573 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 632
Query: 1149 SNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILV 1208
S ++ +G L+I DAG Y C NS LR+ L+
Sbjct: 633 SPRFEILPEGS---LRIQPVLAQDAGHYLCLASNS-------AGSDRQGRDLRV--LALL 680
Query: 1209 PANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC 1268
P P V W+K ++ + + L++ D ++ C
Sbjct: 681 PCEASGS-----PKPL--VVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFEC 733
Query: 1269 VLL-DAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
V+ + +L V PP I D + ++ + + V L P P W
Sbjct: 734 VVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ 793
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKP 1387
+ + + + S S +L I + AG Y N+ G A + +T+ P P
Sbjct: 794 LG-ARGSGYRV-SPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLP 851
Query: 1388 NILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNS 1447
+++ + + E TI + + + ++ +S + + Q I +
Sbjct: 852 SVVRAVAEEEVLLPCEASGIPRPTITW---QKEGLNVATGVSTQVLPGGQLRIAHASPED 908
Query: 1448 SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
+ + A N S +T +V P +E L +++T L C G
Sbjct: 909 AGNYLCIAKNSAG-SAMGKTRLVVQV-------PPVIENGLPDLSTTEGSHAFLPCKARG 960
Query: 1508 VPQPKVTWYRDGKKLKTA--KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV 1565
P+P +TW +DG+ + A K T + Y C A N G +
Sbjct: 961 SPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHL 1020
Query: 1566 GIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE 1625
I PV T D + ++GD + G P P + W N + ++ ++
Sbjct: 1021 TILVLPVFTTLPGD--RSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTE----GVSEQD 1074
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
S ++ + R S Y A N G + + V + P
Sbjct: 1075 GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 1115
Score = 78.6 bits (185), Expect = 2e-13
Identities = 50/216 (23%), Positives = 96/216 (44%), Gaps = 7/216 (3%)
Query: 1459 VDISDASETTEYYKVIKETKIQSPTVEKPLK--NITTEPNEDIELTCIFGGVPQPKVTWY 1516
V +S+A E ++++ T ++ P +E + ++ P +EL C G PQP +TW+
Sbjct: 385 VAVSEAGEARRHFQL---TVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWH 441
Query: 1517 RDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITIS 1576
+DG+ L + Y C+A + G +E S V +Q P I
Sbjct: 442 KDGQALTRLENNSRATRVLRVENVQVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGP 501
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELK 1636
+ ++ +E P P++ W+++G L+ D E+ ++++ L
Sbjct: 502 RGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQF--PERGRFLQLQALS 559
Query: 1637 RSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+ S Y+ A N AG++SV ++++ P+ GP
Sbjct: 560 TADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGP 595
Score = 71.3 bits (167), Expect = 3e-11
Identities = 72/292 (24%), Positives = 130/292 (44%), Gaps = 32/292 (10%)
Query: 632 IPPTFSKKPKAQYVDE--GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+PPTF + PK + V + GS ++L C + +P P + WL ++ +P E+ +V +
Sbjct: 35 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWL---KDRMPVESSAV---HGVV 87
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+++ ++ Q GTYT VA N + EA V+ + + + + V +G
Sbjct: 88 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGV--AREHHVLEG 145
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPV-----KALPTKSDGDTHSITILKPKKVKDEGVYT 804
+ V L + G P P + W K+ P+ L DG + +LK D G YT
Sbjct: 146 QEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGS---LVLKGLWASDAGAYT 202
Query: 805 LKAENSEG-IAETSAVITVEEPT-EENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPV 861
A N G A V + PT ++ A+ ++R E+ + +V V +P
Sbjct: 203 CVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGEL-------VTMVCPVRGSPP 255
Query: 862 PSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
++W ++ + S+ + G + + + D+G + CVA++ AG
Sbjct: 256 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL---ADAGIFTCVAASPAG 304
Score = 70.5 bits (165), Expect = 6e-11
Identities = 52/195 (26%), Positives = 80/195 (41%), Gaps = 7/195 (3%)
Query: 1482 PTVEKP-LKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXX 1538
PT E P + ++ + LTC GVP P VTW +D ++++
Sbjct: 37 PTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLS 96
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV--GDEWLVTAVI 1596
Y C+A N E VV + P I S + ++H V G E +
Sbjct: 97 RLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSG--VAREHHVLEGQEVRLDCEA 154
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
+G PPP+V W K+G+ L D ++ + +K L S + YT A N AG +
Sbjct: 155 DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLWASDAGAYTCVAHNPAGEDAR 214
Query: 1657 EVTLKVYDKPSKPEG 1671
T+ V P+ +G
Sbjct: 215 LHTVNVLVPPTIKQG 229
Score = 66.1 bits (154), Expect = 1e-09
Identities = 129/627 (20%), Positives = 225/627 (35%), Gaps = 55/627 (8%)
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-I 850
++ +V D+G+Y+ K N G A + +TV+ P P F N E + G+ +
Sbjct: 3 IQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVP-------PTFENPKTETVSQVAGSPL 55
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
L V+ P P++TW ++ + S G ++L +G Y CVA N
Sbjct: 56 VLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQ---PAQAGTYTCVAEN 112
Query: 911 SAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEIS 968
+ ++ V + V + + + EG+ V L+C+ W + +
Sbjct: 113 TQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPL- 171
Query: 969 GMD---HREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRKL 1023
G D H +G D G C+ + E + + V +P I++
Sbjct: 172 GQDMGPHLRFYLDG--GSLVLKGLWASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQG 229
Query: 1024 QD----FEVKEKDVAILEVEI-NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRN 1078
D + ++ + + S V W +DG + P + GH L I
Sbjct: 230 ADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG-LPLPLSQRTLLHGSGH--TLRISK 286
Query: 1079 TSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-- 1136
+ D G ++C+ + A+ P +R ++ A + + A
Sbjct: 287 VQLADAGIFTCVAASPAGVADRNFTLQCPLSWSRWSSRMTWWWFVAPWWNSRARPGAFPC 346
Query: 1137 --VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILT 1190
R KDG + S ++ + L++ D+G YSC E G ++ LT
Sbjct: 347 LSCRGMKDGEPL-LSQSLE-----QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT 400
Query: 1191 V-EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVK 1249
V E P I + + E L P L ++TW+K + E +
Sbjct: 401 VMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLEN----NSRA 456
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRG---SDV 1305
R L + D YTC+ + V V+ PP IV R R G +
Sbjct: 457 TRVLRVENVQVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVG-PRGPRFVVGLAPGQL 515
Query: 1306 TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENN 1365
L +A P P W + ++++ HT+ + L ++ + D+G Y N
Sbjct: 516 VLECSVEAEPAPKITWHRDGIVLQEDAHTQ--FPERGRFLQLQALSTADSGDYSCTARNA 573
Query: 1366 CGHADVEMNVTILDKPSPPGKPNILEI 1392
G V V I P+ P + +
Sbjct: 574 AGSTSVAFRVEIHTVPTIRSGPPAVNV 600
Score = 63.3 bits (147), Expect = 9e-09
Identities = 62/284 (21%), Positives = 112/284 (39%), Gaps = 24/284 (8%)
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
S +P + G+ + L C P+P+I W G+ + EN S A VL+
Sbjct: 410 SGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATR--------VLR 461
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL--KSMIVRQGESVIL 754
+ NV+ G YT +A + G ++++ PP ++ P + ++ ++L
Sbjct: 462 VENVQVRDAGLYTCLAESPAGAIEKSFRVRVQA----PPNIVGPRGPRFVVGLAPGQLVL 517
Query: 755 SAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V P P ITW ++ ++ + L+ D G Y+ A N+ G
Sbjct: 518 ECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGST 577
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
+ + + + PP + V T L + P P ++W ++ +
Sbjct: 578 SVAFRVEIHTVPTIRSGPPA-------VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLD 630
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
P + ++ I V ++ D+G Y C+ASNSAG G
Sbjct: 631 PRSPRFEILPEGSLR--IQPVLAQ-DAGHYLCLASNSAGSDRQG 671
Score = 62.9 bits (146), Expect = 1e-08
Identities = 59/227 (25%), Positives = 95/227 (41%), Gaps = 19/227 (8%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ--GESV 752
L+I + +G Y+ N GEA L ++ PP P K+ V Q G +
Sbjct: 1 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV----PPTFENP-KTETVSQVAGSPL 55
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTK---SDGDTHSITILKPKKVKDEGVYTLKAEN 809
+L+ V G P PT+TW K+ PV++ S G ++ L+P + G YT AEN
Sbjct: 56 VLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQA---GTYTCVAEN 112
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
++ A V+ V + +E V E ++L P P + W ++
Sbjct: 113 TQAEARKDFVVAVLVAPRIRSS-----GVAREHHVLEGQEVRLDCEADGQPPPDVAWLKD 167
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+ F + LV+ + + D+G Y CVA N AG+ +
Sbjct: 168 GSPLGQDMGPHLRFYLDGGSLVLKGLWAS-DAGAYTCVAHNPAGEDA 213
Score = 61.3 bits (142), Expect = 4e-08
Identities = 47/190 (24%), Positives = 75/190 (39%), Gaps = 10/190 (5%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKL--KTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDH 1556
L C G P+P V W++DG+KL + + Y ++C+ N+
Sbjct: 680 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 739
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKL-EN 1615
GE V + P I D ++T GIP P V W K G +L
Sbjct: 740 GEAHRLYQVTVHVPPTIADDQTDFTVTMMA--PVVLTCHSTGIPAPTVSWSKAGAQLGAR 797
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIM 1675
Y ++ + + I + H+ +YT A N+AG + V L V P P ++
Sbjct: 798 GSGYRVSP---SGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVV 854
Query: 1676 REISRESVTI 1685
R ++ E V +
Sbjct: 855 RAVAEEEVLL 864
Score = 57.6 bits (133), Expect = 5e-07
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 7/176 (3%)
Query: 641 KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNV 700
+ +V EG ++ L+C P PD+AWL G + D + D L + +
Sbjct: 138 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLD----GGSLVLKGL 193
Query: 701 KKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVG 760
G YT VA N GE + + + Q + +++ R GE V + V G
Sbjct: 194 WASDAGAYTCVAHNPAGEDARLHTVNVLV-PPTIKQGADGSGTLVSRPGELVTMVCPVRG 252
Query: 761 NPRPTITWCKNNKPVK-ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
+P ++W K+ P+ + T G H++ I K ++ D G++T A + G+A+
Sbjct: 253 SPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISK-VQLADAGIFTCVAASPAGVAD 307
Score = 54.4 bits (125), Expect = 4e-06
Identities = 28/77 (36%), Positives = 38/77 (49%), Gaps = 4/77 (5%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V C+ G PRP ITW ++ + Q+ L I PEDAG + C+AK
Sbjct: 862 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ----LRIAHASPEDAGNYLCIAK 917
Query: 587 NAAGFASSTTELIVEAP 603
N+AG A T L+V+ P
Sbjct: 918 NSAGSAMGKTRLVVQVP 934
Score = 50.8 bits (116), Expect = 5e-05
Identities = 22/74 (29%), Positives = 39/74 (52%), Gaps = 1/74 (1%)
Query: 517 RPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPE 576
R H +G V+ +C+ +G P P + W + + + + + D +LV++ ++
Sbjct: 138 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG-GSLVLKGLWAS 196
Query: 577 DAGTFTCVAKNAAG 590
DAG +TCVA N AG
Sbjct: 197 DAGAYTCVAHNPAG 210
Score = 50.0 bits (114), Expect = 9e-05
Identities = 54/228 (23%), Positives = 91/228 (39%), Gaps = 11/228 (4%)
Query: 1163 LKIYDCDLDDAGEYSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTV 1218
L+I + + D G YSC+V N A+ LTV+ P F E + A + LT
Sbjct: 1 LEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP-TFENPKTETVSQVAGSPLVLTC 59
Query: 1219 EIPD-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
++ VTW K + +E + ++S + L + + YTCV + ++
Sbjct: 60 DVSGVPAPTVTWLKDRMPVESSAVHGVVS--RGGRLQLSRLQPAQAGTYTCVAENTQAEA 117
Query: 1278 KLK-VEVVEFPPKI--VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
+ V V P+I RE+ + G +V L + P P+ W+ + + +
Sbjct: 118 RKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGP 177
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
SL +K + +DAG Y N G V +L P+
Sbjct: 178 HLRFYLDGGSLVLKGLWASDAGAYTCVAHNPAGEDARLHTVNVLVPPT 225
Score = 48.0 bits (109), Expect = 4e-04
Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 3/91 (3%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+ L T +GS C+ G P P ITW + +P + + L+
Sbjct: 935 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG---QPVSGAEGKFTIQPSGELL 991
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
++ + +DAGT+TC A+NA G A L +
Sbjct: 992 VKNLEGQDAGTYTCTAENAVGRARRRVHLTI 1022
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 4/92 (4%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP+F + + G V CQ G P P I W + ++ S+ + D +L
Sbjct: 1205 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD----GSL 1260
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ V DAGT+ CVA N G A++ L+V
Sbjct: 1261 WLENVETGDAGTYDCVAHNLLGSATARAFLVV 1292
Score = 45.6 bits (103), Expect = 0.002
Identities = 31/127 (24%), Positives = 54/127 (42%), Gaps = 6/127 (4%)
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWY 1607
Y C+A ++ GE + + + P I S + + G + +G P P + W+
Sbjct: 382 YSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWH 441
Query: 1608 KNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS 1667
K+G L E N T V+R++ ++ + YT A + AG ++V P+
Sbjct: 442 KDGQALTR-LENN---SRATRVLRVENVQVRDAGLYTCLAESPAGAIEKSFRVRVQAPPN 497
Query: 1668 --KPEGP 1672
P GP
Sbjct: 498 IVGPRGP 504
Score = 44.4 bits (100), Expect = 0.005
Identities = 42/171 (24%), Positives = 65/171 (38%), Gaps = 9/171 (5%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT----YENRXXXXXXXXXXXXXXXYKCIA 1552
+++ L C G P P V W +DG L Y + Y C+A
Sbjct: 146 QEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLWASDAGAYTCVA 205
Query: 1553 FNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV--IEGIPPPEVIWYKNG 1610
N GE V + P I + E LVT V + G PP V W K+G
Sbjct: 206 HNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE-LVTMVCPVRGSPPIHVSWLKDG 264
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
L + + T +RI +++ + + +T A++ AG + TL+
Sbjct: 265 LPLPLSQRTLLHGSGHT--LRISKVQLADAGIFTCVAASPAGVADRNFTLQ 313
Score = 44.4 bits (100), Expect = 0.005
Identities = 37/149 (24%), Positives = 62/149 (41%), Gaps = 16/149 (10%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G ++Q +C V G P P I W + P + + + N +L I +DAG +
Sbjct: 1128 PVGGSIQLDCVVRGDPVPDIHWIKDGL---PLRGSHLRHQLQN-GSLTIHRTERDDAGRY 1183
Query: 582 TCVAKNAAGFASSTTELIVE-APLSD-HGSEMTVXXXXXXXXXXXXADILEGIPPTFSKK 639
C+A+N G A L+++ AP+ +MTV D+ T
Sbjct: 1184 QCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGD---------DVALRCQATGEPT 1234
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWL 668
P +++ G + RL +P+ + WL
Sbjct: 1235 PTIEWLQAGQPLRASRRLRTLPDGSL-WL 1262
Score = 42.7 bits (96), Expect = 0.014
Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 3/64 (4%)
Query: 530 ECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAA 589
EC VE P P+ITW R +++ Q + L ++ + D+G ++C A+NAA
Sbjct: 518 ECSVEAEPAPKITWHRDGIVLQEDAHTQF---PERGRFLQLQALSTADSGDYSCTARNAA 574
Query: 590 GFAS 593
G S
Sbjct: 575 GSTS 578
Score = 41.9 bits (94), Expect = 0.024
Identities = 26/85 (30%), Positives = 45/85 (52%), Gaps = 10/85 (11%)
Query: 521 TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR--EVFPEDA 578
TP G+ ++ C +G P+P ITW + + ++++ AT V+R V DA
Sbjct: 419 TP-GAPMELLCDAQGTPQPNITWHKDGQALTR-------LENNSRATRVLRVENVQVRDA 470
Query: 579 GTFTCVAKNAAGFASSTTELIVEAP 603
G +TC+A++ AG + + V+AP
Sbjct: 471 GLYTCLAESPAGAIEKSFRVRVQAP 495
Score = 41.1 bits (92), Expect = 0.042
Identities = 26/95 (27%), Positives = 39/95 (41%), Gaps = 7/95 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F +P+ V G D+ L C+ P P I WL G+ + + +
Sbjct: 1206 PVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGS------ 1259
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
L + NV+ GTY VA N G A+ L ++
Sbjct: 1260 -LWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 1293
Score = 40.7 bits (91), Expect = 0.056
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 5/80 (6%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKP-SQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
T CQ +G P P ++W + + P S F++ + +L I+ V +DAG + C+
Sbjct: 605 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPE----GSLRIQPVLAQDAGHYLCL 660
Query: 585 AKNAAGFASSTTELIVEAPL 604
A N+AG +L V A L
Sbjct: 661 ASNSAGSDRQGRDLRVLALL 680
Score = 39.9 bits (89), Expect = 0.098
Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 3/64 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS + C V G P P +TW + P + ++ L + + P AGT+TC
Sbjct: 52 GSPLVLTCDVSGVPAPTVTWLKDR---MPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTC 108
Query: 584 VAKN 587
VA+N
Sbjct: 109 VAEN 112
Score = 39.1 bits (87), Expect = 0.17
Identities = 29/89 (32%), Positives = 37/89 (41%), Gaps = 3/89 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G V C V G P ++W + + SQ ++ TL I +V DAG FTC
Sbjct: 241 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGH---TLRISKVQLADAGIFTC 297
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMT 612
VA + AG A L S S MT
Sbjct: 298 VAASPAGVADRNFTLQCPLSWSRWSSRMT 326
Score = 35.9 bits (79), Expect = 1.6
Identities = 23/76 (30%), Positives = 32/76 (42%), Gaps = 3/76 (3%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V C G P P ++W + A + Y L I + P AG +TC A+
Sbjct: 771 VVLTCHSTGIPAPTVSWSKAGAQLGARGSG---YRVSPSGALEIGQALPIHAGRYTCSAR 827
Query: 587 NAAGFASSTTELIVEA 602
N+AG A L V+A
Sbjct: 828 NSAGVAHKHVFLTVQA 843
Score = 35.1 bits (77), Expect = 2.8
Identities = 26/96 (27%), Positives = 42/96 (43%), Gaps = 6/96 (6%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P+F + G + C G P P+I W T +P + + D +TL
Sbjct: 1026 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW---TVNDRPVTEGVS--EQDGGSTLQ 1080
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAPL 604
V ED+GT+ C A+N G + + + + EAP+
Sbjct: 1081 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPV 1116
Score = 34.3 bits (75), Expect = 4.9
Identities = 21/88 (23%), Positives = 40/88 (45%), Gaps = 9/88 (10%)
Query: 531 CQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA---TLVIREVFPEDAGTFTCVAKN 587
C+ G P+P + W++ + DF++ + L++ P+D+ F CV N
Sbjct: 682 CEASGSPKPLVVWWKDGQKL----DFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSN 737
Query: 588 AAGFASSTTELIVEAP--LSDHGSEMTV 613
G A ++ V P ++D ++ TV
Sbjct: 738 EVGEAHRLYQVTVHVPPTIADDQTDFTV 765
>EF063638-1|ABO42328.1| 1896|Homo sapiens obscurin-like 1 isoform A
protein.
Length = 1896
Score = 149 bits (362), Expect = 8e-35
Identities = 272/1274 (21%), Positives = 483/1274 (37%), Gaps = 129/1274 (10%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K +S +Q P F+ RP G+ + +C V G P P + W + + S+ +
Sbjct: 2 KASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLS-F 60
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFA-SSTTELIVEAPLSDHGSEMTVXXXXX 618
D L++ P DAG + C A+NAAG A ++ ++E P SD E+
Sbjct: 61 PADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASD--PELQPAERPL 118
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKG---EEIV 675
EG P F P++Q+V G++++L CR +PEP + W G +E+
Sbjct: 119 PSPGSG-----EG-APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVW 172
Query: 676 PDENISV--AIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE 733
+ ++ D L+I + G Y A N G A +L++ +
Sbjct: 173 DSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPES 232
Query: 734 PP--------QVIEPL----KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK 781
PP V+EPL K+ V +G+ V+G P P I W +P+ LP +
Sbjct: 233 PPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL--LPDR 290
Query: 782 -----SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFI 836
D D + + + KD G+Y A NS G ++ + V+EP P
Sbjct: 291 RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRP---- 346
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
Q++ +E G L +V + +P+ W+R ++ + P Q +G L+I +
Sbjct: 347 --LQDVEGREHGIAVLECKVPNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLK 403
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT- 955
++ D G Y C G+ A VT+ K +K L + + EG+ +L +T
Sbjct: 404 AD-DDGIYLC---EMRGRVRTVANVTV---KGPILKRLPRKLDVLEGENAVLLVETLEAG 456
Query: 956 VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVK-- 1013
V +W + +E+ + G D G + + + T+T+L VK
Sbjct: 457 VEGRWSRDGEELPVICQS---SSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCV 513
Query: 1014 ETIPEFIRKLQDFEVKEKDVAIL---EVEINSETADVV-WERDGEIIKPKKNKYDFEKRG 1069
+ P L + K+ +L E ET + ER + + EK G
Sbjct: 514 KHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAG 573
Query: 1070 HIRKLYIRNTSVHDEGEYS---CILRDESCTAEVTV---VELPP--EIITRLQNQKVNKG 1121
+ + V EG+Y C + + V L P ++ L++ +V G
Sbjct: 574 AVE---VPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDG 630
Query: 1122 NKATFEIELTKGDALVRWFKDGSEIQFSN----------HIQLTIDGKKQKLKIYDCDLD 1171
A F ++L+ WF +G E++ + ++ G + +L ++
Sbjct: 631 EDAVFSLDLST-IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQ 689
Query: 1172 DAGE---YSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTD-AYLTVEIPDETLDV 1227
D+G +SC + +A LT++E ++ L ++ LT E+
Sbjct: 690 DSGALVGFSCP--GVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA 747
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP 1287
TWYK +E++E + D +K LI+ + D E+ C + V V + P
Sbjct: 748 TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF--FGVTVQDPP 805
Query: 1288 PKIVDYEREYRIKRG--SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
IVD RE+ S+ +L W + + +++ + L
Sbjct: 806 VHIVD-PREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRL 864
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS----PPGKPNILEIDSSSINICW 1401
+ + +D G ++ + C + VTI D S P GK + + + +
Sbjct: 865 VLPATQPSDGGEFQCVAGDECAY----FTVTITDVSSWIVYPSGKVYVAAVRLERVVLTC 920
Query: 1402 DEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
+ + + + +E +++ + K T + + ++ S + + E+D
Sbjct: 921 ELCRPWAE---VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY----LCEID 973
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK 1520
AS T + +I P E L +T E + L C P V WY+DG
Sbjct: 974 DESASFTVTVTE--PPVRIIYPRDEVTLIAVTL---ECVVLMCELSREDAP-VRWYKDGL 1027
Query: 1521 KLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDI 1580
+++ ++A R D G+ V + P +
Sbjct: 1028 EVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAAR 1087
Query: 1581 KQKHKVGDEWLVTAVIEGIPP-PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSH 1639
G V E P +V WYK+G ++E + + T + + +
Sbjct: 1088 SLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPED 1147
Query: 1640 SSKYTIEASNTAGTSSVEVT------LKVYDKPS----KPEGPVIMR-EISRESVTIEWK 1688
+ +Y E + A T +V + L + PS P PV++ E+SR + W
Sbjct: 1148 AGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWS 1207
Query: 1689 ---PPLDDG-GLEL 1698
P+ +G GLEL
Sbjct: 1208 HNGRPVQEGEGLEL 1221
Score = 142 bits (344), Expect = 1e-32
Identities = 127/551 (23%), Positives = 223/551 (40%), Gaps = 21/551 (3%)
Query: 736 QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPT--KSDGDTHSITILK 793
+++ L + V +G+ +V P +TW +N V P + + I L+
Sbjct: 1361 KLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLR 1419
Query: 794 PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLV 853
++ D G TL+A G TSA + V E TE LF+ R Q++ +E + L
Sbjct: 1420 GCQLGDAGTVTLRA----GSTATSARLHVRE-TEL-----LFLRRLQDVRAEEGQDVCLE 1469
Query: 854 ARVTR-NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSA 912
R ++ W R + + ++ DG L I V D G Y C + +
Sbjct: 1470 VETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILA-DQGTYGCESHHDR 1528
Query: 913 GKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDH 972
AR+++ ++ ++ L+ +E G + V+ +W ++
Sbjct: 1529 TL----ARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPK 1584
Query: 973 REIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKD 1032
I +G D G + + L+V+E +R D EV E D
Sbjct: 1585 CHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGD 1644
Query: 1033 VAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILR 1092
A E E++ ADV WE+DG + P + + G R L +R D G YSC +
Sbjct: 1645 TATFECELSQALADVTWEKDGNALTPSP-RLRLQALGTRRLLQLRRCGPSDAGTYSCAVG 1703
Query: 1093 DESC-TAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNH 1151
+TV E +++ L++ +G+ ATFE +++ + RW G ++
Sbjct: 1704 TARAGPVRLTVRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGAR 1763
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPAN 1211
+++ +GKK L + + +DAGE + G ++ A+L VE + P V
Sbjct: 1764 VRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVG 1823
Query: 1212 TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
A L V + V W ++ + + +K+ + S +L+I +DQ Y C
Sbjct: 1824 RRAVLEVTVSRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAG 1883
Query: 1272 DAKSTTKLKVE 1282
+ T+L VE
Sbjct: 1884 QDSTHTRLLVE 1894
Score = 140 bits (339), Expect = 5e-32
Identities = 152/656 (23%), Positives = 255/656 (38%), Gaps = 40/656 (6%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P V G ++L C L P + W G + E + + E + C I
Sbjct: 1180 PSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAEGPRRVLC----IQA 1234
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP-QVIEPLKSMI-VRQGESVILSAQ 757
G YT + G SL +++ EPP +V+ P + VR L
Sbjct: 1235 AGPAHAGLYTCQSGAAPGAPSLSFTVQVA----EPPVRVVAPEAAQTRVRSTPGGDLELV 1290
Query: 758 V-VGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAENSEGIA 814
V + P + W K+ + + + + +L+ + + D G Y A I
Sbjct: 1291 VHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIF 1350
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
+++VEEP ++ +TV E V+ P +TW RN +++
Sbjct: 1351 ----LVSVEEPLLVK-----LVSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVT 1400
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL 934
P + +G + L + GD V AG ++ AR+ + ++ F++ L
Sbjct: 1401 PGPQVEMAQNGSSRILTLRGCQL----GDAGTVTLR-AGSTATSARLHVRETELLFLRRL 1455
Query: 935 QKSYETEEGKTVILECQTSHTVST---KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXX 991
Q EEG+ V LE +T + +W + + + Q+G
Sbjct: 1456 Q-DVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVIL 1514
Query: 992 XDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWER 1051
D G C T L V+ +R L+D + E A ++E++ E W R
Sbjct: 1515 ADQGTYGCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWAR 1574
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIIT 1111
G + P K GH +L + + D G S C A + V E+P I+
Sbjct: 1575 GGVQLYPGP-KCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVR 1633
Query: 1112 RLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLD 1171
+ +V +G+ ATFE EL++ A V W KDG+ + S ++L G ++ L++ C
Sbjct: 1634 GPHDLEVTEGDTATFECELSQALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPS 1693
Query: 1172 DAGEYSCEVGNSKCTAI-LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVT-- 1228
DAG YSC VG ++ + LTV E ++ L E V A T E ++ T
Sbjct: 1694 DAGTYSCAVGTARAGPVRLTVRERTVAV---LSELRSVSAREGDGATFECTVSEVETTGR 1750
Query: 1229 WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
W + + + + KK L++ + +D E A+S L+VE +
Sbjct: 1751 WELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQAGPAQSLALLEVEAL 1806
Score = 133 bits (321), Expect = 8e-30
Identities = 141/600 (23%), Positives = 243/600 (40%), Gaps = 36/600 (6%)
Query: 729 TGEKEPPQVIEPLK--SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSD 783
T ++ P ++ P S+ E V+L+ ++ P TW K+ + V+ L K D
Sbjct: 709 TIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKMD 767
Query: 784 GDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G H + IL KV+D G + + +EG++ V TV++P +P + F
Sbjct: 768 GRKHRL-ILPEAKVQDSGEFECR---TEGVSAFFGV-TVQDPPVHIVDPREHV--FVHAI 820
Query: 844 VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
E + L V R P + WY++ + + S+ + +G + LV+ D G+
Sbjct: 821 TSE--CVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPS-DGGE 876
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG-KTVILECQTSHT-VSTKWY 961
++CVA + + VTI V K Y + V+L C+ +W
Sbjct: 877 FQCVAGDECAYFT----VTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWT 932
Query: 962 HNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIR 1021
+ +E+ + +E D G C + D+ S + V E I
Sbjct: 933 KDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIY 992
Query: 1022 KLQDFEV--KEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNT 1079
+ + + +L E++ E A V W +DG ++ + E+ G +L +
Sbjct: 993 PRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVE-ESEALVLERDGPRCRLVLPAA 1051
Query: 1080 SVHDEGEYSCILRDESCTAEVTVVELPPEII---TRLQNQKVNKGNKATFEIELTKGDAL 1136
D GE+ C D+S VTV P I+ R + + E+ +
Sbjct: 1052 QPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ 1111
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSI 1196
VRW+KDG E++ S+ +QL +G + L + +DAGEY CE + T + + EP +
Sbjct: 1112 VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPV 1171
Query: 1197 NFTL--RLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLI 1254
F P + V L+ E+ V W +++ E L ++ +R L
Sbjct: 1172 QFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLC 1231
Query: 1255 IRKCTEDDQCEYTCVLLDAKSTTKLK--VEVVEFPPKIVDYE-REYRIKR--GSDVTLLV 1309
I+ YTC A L V+V E P ++V E + R++ G D+ L+V
Sbjct: 1232 IQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVV 1291
Score = 123 bits (297), Expect = 6e-27
Identities = 128/576 (22%), Positives = 223/576 (38%), Gaps = 33/576 (5%)
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTK--SDGDTHSITILKPKKVKDEGVYTLKA 807
E V+L+ ++ P + W K+ + V P DT +L +++D G Y +
Sbjct: 914 ERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI 972
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
++ S +TV EP P + +T++ + L+ ++R P + WY
Sbjct: 973 DDESA----SFTVTVTEPPVRIIYPRDEVTLIA-VTLE---CVVLMCELSREDAP-VRWY 1023
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
++ + SE + DG LV+ E D G++ C AG S VT+
Sbjct: 1024 KDGLEVEESEALVLERDGPRCRLVLPAAQPE-DGGEFVC----DAGDDSAFFTVTVTAPP 1078
Query: 928 VTFVKHLQKSYETEEGKT--VILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXX 984
V +S + G V L C+ + S +WY + E+ D ++ EG
Sbjct: 1079 ERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTL 1138
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILEVEIN 1041
D G C + + + +++ E +F+ V + +L E++
Sbjct: 1139 TLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELS 1198
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC----ILRDESCT 1097
A VVW +G ++ + + G R L I+ G Y+C S +
Sbjct: 1199 RAGAPVVWSHNGRPVQEGEG-LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLS 1257
Query: 1098 AEVTVVELPPEIITRLQNQ---KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQL 1154
V V E P ++ Q + G + L+ VRW+KDG + +QL
Sbjct: 1258 FTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQL 1317
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
G +Q L++ DAGEY C+ +++VEEP + + + V DA
Sbjct: 1318 EQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDA 1377
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E+ DVTW + +V+ + + + R L +R C D T L
Sbjct: 1378 TFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGD--AGTVTLRAGS 1435
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD 1310
+ T ++ V E + ++ R + G DV L V+
Sbjct: 1436 TATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVE 1471
Score = 119 bits (287), Expect = 1e-25
Identities = 142/732 (19%), Positives = 280/732 (38%), Gaps = 40/732 (5%)
Query: 946 VILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ 1004
V+L C+ S WY + +++ + + +GR D G +C +
Sbjct: 734 VVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV 793
Query: 1005 ETSTMLVVKETIPEFIRKLQDFEVKE--KDVAILEVEINSETADVVWERDGEIIKPKKNK 1062
+ V++ + + V + +L E++ E A V W +DG+ ++ + +
Sbjct: 794 SAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVE-ESDF 852
Query: 1063 YDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVN--K 1120
E G R+L + T D GE+ C+ DE VT+ ++ I+ V +
Sbjct: 853 VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVR 912
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
+ EL + A VRW KDG E+ S + L + ++L + L+D+GEY CE+
Sbjct: 913 LERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI 972
Query: 1181 GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAY-LTVEIPDETLDVTWYKKKSVIEDT 1239
+ + +TV EP + E L+ + L E+ E V WYK +E++
Sbjct: 973 DDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEES 1032
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYE--REY 1297
E L D + L++ +D E+ C DA + V PP+ + + R
Sbjct: 1033 EALVLERDGPRCRLVLPAAQPEDGGEFVC---DAGDDSAFFTVTVTAPPERIVHPAARSL 1089
Query: 1298 RIKRGSDVTLLVDYQAFPQPND-EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAG 1356
+ G+ + + + P + W + ++ + + + +LT+ + DAG
Sbjct: 1090 DLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1149
Query: 1357 IYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEP-----ENTGNST 1411
Y H + NV + + PP + LE S + + EP E +
Sbjct: 1150 EYVCETR----HEAITFNVILAE---PPVQFLALETTPSPLCVAPGEPVVLSCELSRAGA 1202
Query: 1412 IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
+ + + + E + + + + ++ Y + + + +
Sbjct: 1203 PVVWSHNGRPVQEGEGLELH--AEGPRRVLCIQAAGPAHAGLYTCQS-GAAPGAPSLSFT 1259
Query: 1472 KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT-AKATYE 1530
+ E ++ E + + P D+EL G P V WY+DG++L + + E
Sbjct: 1260 VQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLE 1318
Query: 1531 N---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVG 1587
R Y C A D +V +++ ++ + +E G
Sbjct: 1319 QAGARQVLRVQGARSGDAGEYLCDAPQD----SRIFLVSVEEPLLVKLVSELTPLTVHEG 1374
Query: 1588 DEWLVTAVIEGIPPP-EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
D+ T E PP +V W +NG + + + + ++ ++ + + T+
Sbjct: 1375 DD--ATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1432
Query: 1647 ASNTAGTSSVEV 1658
A +TA ++ + V
Sbjct: 1433 AGSTATSARLHV 1444
Score = 118 bits (284), Expect = 2e-25
Identities = 129/519 (24%), Positives = 212/519 (40%), Gaps = 59/519 (11%)
Query: 725 LKIKTGEK-EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPT 780
+K +G++ PP + + + V G L V+G P P + W K + + A L
Sbjct: 1 MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF 60
Query: 781 KSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE--------- 831
+DG H + +L D GVY +A N+ G A +A +TV EP + E
Sbjct: 61 PADGAEHGL-LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLP 119
Query: 832 -------PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN----NEIISPSETIT 880
P+F+ + V + L R P P++ W ++ +E+ S
Sbjct: 120 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
Query: 881 QNF---DGENIELVITNVDSEI-DSGDYKCVASNSAGKSSHGARVTI-----------DV 925
Q DG L + + + + DSG Y C A N+ G + GA + + D
Sbjct: 180 QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDE 239
Query: 926 EKVTFVKHLQ---KSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGR 980
V+ L+ K++ EGK C +W+ + + D R ++ R
Sbjct: 240 APAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP-DRRRLMYRDR 298
Query: 981 XXXXXXXXXX--XXDVGVIKCIVKDQETSTM----LVVKETIPEFIRKLQDFEVKEKDVA 1034
D G+ C ++ T+ L VKE F R LQD E +E +A
Sbjct: 299 DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIA 358
Query: 1035 ILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
+LE ++ + W R+ + + P + KY+ + G +R+L I D+G Y C +R
Sbjct: 359 VLECKVPNSRIPTAWFREDQRLLPCR-KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGR 417
Query: 1095 SCTAEVTVVELPPEIITRLQNQ-KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
T V+ P I+ RL + V +G A +E + RW +DG E+ I
Sbjct: 418 VRTVANVTVKGP--ILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---IC 472
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
+ G L + +DAGE + +GNS+ T +L V+
Sbjct: 473 QSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVK 511
Score = 93.5 bits (222), Expect = 7e-18
Identities = 153/748 (20%), Positives = 278/748 (37%), Gaps = 52/748 (6%)
Query: 651 ILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTV 710
++L C L + P W G+++ E + V ++ H L + K G +
Sbjct: 734 VVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHR----LILPEAKVQDSGEFEC 788
Query: 711 VAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ--GESVILSAQVVGNPRPTITW 768
EG ++ V T + P +++P + + V E V+L+ +V P + W
Sbjct: 789 ---RTEGVSAFFGV----TVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRW 840
Query: 769 CKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
K+ + V+ + +++G H +L + D G + A G +T+ +
Sbjct: 841 YKDGQEVEESDFVVLENEGP-HRRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDV 895
Query: 826 TEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
+ P + V+ + + L + R P + W ++ E + S + +
Sbjct: 896 SSWIVYPS---GKVYVAAVRLERVV-LTCELCR-PWAEVRWTKDGEEVVESPALLLQKED 950
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
LV+ V E DSG+Y C + + +S VT ++ + + + + +
Sbjct: 951 TVRRLVLPAVQLE-DSGEYLCEIDDES--ASFTVTVTEPPVRIIYPRD-EVTLIAVTLEC 1006
Query: 946 VILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ 1004
V+L C+ S +WY + E+ + + ++G D G C D
Sbjct: 1007 VVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDD 1066
Query: 1005 E---TSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKN 1061
T T+ E I + D L E+ + V W +DG ++ +
Sbjct: 1067 SAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS-D 1125
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEII---TRLQNQKV 1118
G R L + + D GEY C R E+ T V + E P + + T V
Sbjct: 1126 ALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCV 1185
Query: 1119 NKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC 1178
G EL++ A V W +G +Q ++L +G ++ L I AG Y+C
Sbjct: 1186 APGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTC 1245
Query: 1179 EVGNSKCTAILT----VEEPSINFTLRLPEFILVPANT--DAYLTVEIPDETLDVTWYKK 1232
+ G + L+ V EP + V + D L V + V WYK
Sbjct: 1246 QSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKD 1305
Query: 1233 KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP--PKI 1290
+ + L ++ L ++ D EY C DA +++ + VE P K+
Sbjct: 1306 GERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC---DAPQDSRIFLVSVEEPLLVKL 1362
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
V + G D T + P + W+ N ++ + + + S LT++
Sbjct: 1363 VSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGC 1421
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTIL 1378
+ DAG LR + A + + T L
Sbjct: 1422 QLGDAGTVTLRAGSTATSARLHVRETEL 1449
Score = 75.4 bits (177), Expect = 2e-12
Identities = 128/619 (20%), Positives = 229/619 (36%), Gaps = 51/619 (8%)
Query: 1118 VNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLKIYDCDLDDAGE 1175
VN+G A F + K + + W +G + + D LK+ C D G
Sbjct: 257 VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
Query: 1176 YSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYK 1231
Y C NS + L V+EP + FT L + + + A L ++P+ + W++
Sbjct: 317 YVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQD-VEGREHGIAVLECKVPNSRIPTAWFR 375
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
+ + K+ I + R LII + DD Y C + + + V P +
Sbjct: 376 EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTVKGPILK 432
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
R+ + G + LLV+ W S+ ++ S +L + V
Sbjct: 433 RLPRKLDVLEGENAVLLVE-TLEAGVEGRW---SRDGEELPVICQSSSGHMHALVLPGVT 488
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI---DSSSINICWDEPENTG 1408
DAG L N+ + V + K SPPG P + E+ +++ + W PE
Sbjct: 489 REDAGEVTFSLGNS--RTTTLLRVKCV-KHSPPGPPILAEMFKGHKNTVLLTWKPPEPAP 545
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKNITK---TQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
+ IY +E QE+ + +WI +I K + + + YRFR V S
Sbjct: 546 ETPFIYR-LERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTV-----SGHG 599
Query: 1466 ETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
+ + + + L+++ ED + + Q TW+ +G++LK+
Sbjct: 600 RSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFLNGEELKSN 657
Query: 1526 KATYE---NRXXXXXXXXXXXXXXXYKCIAFNDHGE--------VETSCVVGIQQKPVIT 1574
+ + + D G V+ S + IQ+ PV
Sbjct: 658 EPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHI 717
Query: 1575 ISNED-IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
+S +D + + ++T + + P WYK+G K+E + + + + +
Sbjct: 718 LSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILP 776
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP---SKPEGPVIMREISRESVTIEWKPP 1690
E K S ++ T G S+ + V D P P V + I+ E V + +
Sbjct: 777 EAKVQDSGEF---ECRTEGVSAF-FGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVD 832
Query: 1691 LDDGGLELTKYAIEKHEPD 1709
+D + K E E D
Sbjct: 833 REDAPVRWYKDGQEVEESD 851
Score = 56.0 bits (129), Expect = 1e-06
Identities = 35/112 (31%), Positives = 53/112 (47%), Gaps = 5/112 (4%)
Query: 496 PVFEKPTSEEQSMAPIFVEKLR--PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIK 551
P P +++ AP+ VE L+ PK +G +F C V G P P+I W + +
Sbjct: 229 PPESPPADPDEAPAPV-VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 287
Query: 552 PSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
P + MY D D L + +D G + C A+N+AG S +L V+ P
Sbjct: 288 PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP 339
Score = 50.0 bits (114), Expect = 9e-05
Identities = 68/302 (22%), Positives = 120/302 (39%), Gaps = 35/302 (11%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
I+ +P T + P V EG EC L + D+ W G + P + +
Sbjct: 1623 IVREVPVTIVRGPHDLEVTEGDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGT 1681
Query: 688 MHMYCSVLKITNVKKFQEGTYT-VVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+ L++ GTY+ V R G P+ L ++ + V+ L+S+
Sbjct: 1682 RRL----LQLRRCGPSDAGTYSCAVGTARAG----PVRLTVR---ERTVAVLSELRSVSA 1730
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVY 803
R+G+ V T W +P++ + + +G H I +L + +D G
Sbjct: 1731 REGDGATFEC-TVSEVETTGRWELGGRPLRPGARVRIRQEGKKH-ILVLSELRAEDAGEV 1788
Query: 804 TLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+A G A++ A++ VE P + PP R + + V + +++ V+R+
Sbjct: 1789 RFQA----GPAQSLALLEVEALPLQMCRHPP----REKTVLVGRRAVLEVT--VSRSG-G 1837
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W R + P + G LVI +V E D G Y C AG+ S R+
Sbjct: 1838 HVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPE-DQGTYCC----QAGQDSTHTRLL 1892
Query: 923 ID 924
++
Sbjct: 1893 VE 1894
Score = 39.9 bits (89), Expect = 0.098
Identities = 42/231 (18%), Positives = 82/231 (35%), Gaps = 8/231 (3%)
Query: 1466 ETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
E + ++ E +Q +E + P E + L+C P V W +G+ ++
Sbjct: 1158 EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEG 1216
Query: 1526 KATYEN----RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE--D 1579
+ + R Y C + G S V + + PV ++ E
Sbjct: 1217 EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQ 1276
Query: 1580 IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSH 1639
+ + G + + + G P V WYK+G +L + + V+R++ +
Sbjct: 1277 TRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGD 1335
Query: 1640 SSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPP 1690
+ +Y +A + V V + K P+ + E + E PP
Sbjct: 1336 AGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPP 1386
Score = 36.3 bits (80), Expect = 1.2
Identities = 22/61 (36%), Positives = 32/61 (52%), Gaps = 5/61 (8%)
Query: 541 ITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ W R+ A + P ++M +LVI +V PED GT+ C AG S+ T L+V
Sbjct: 1839 VCWLREGAELCPGDKYEMR-SHGPTHSLVIHDVRPEDQGTYCC----QAGQDSTHTRLLV 1893
Query: 601 E 601
E
Sbjct: 1894 E 1894
>EF063637-1|ABO42327.1| 1544|Homo sapiens obscurin-like 1 isoform C
protein.
Length = 1544
Score = 149 bits (360), Expect = 1e-34
Identities = 272/1275 (21%), Positives = 483/1275 (37%), Gaps = 130/1275 (10%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K +S +Q P F+ RP G+ + +C V G P P + W + + S+ +
Sbjct: 2 KASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLS-F 60
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFA-SSTTELIVEAPLSDHGSEMTVXXXXX 618
D L++ P DAG + C A+NAAG A ++ ++E P SD E+
Sbjct: 61 PADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASD--PELQPAERPL 118
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKG---EEIV 675
EG P F P++Q+V G++++L CR +PEP + W G +E+
Sbjct: 119 PSPGSG-----EG-APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVW 172
Query: 676 PDENISV--AIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE 733
+ ++ D L+I + G Y A N G A +L++ +
Sbjct: 173 DSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPES 232
Query: 734 PP--------QVIEPL----KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK 781
PP V+EPL K+ V +G+ V+G P P I W +P+ LP +
Sbjct: 233 PPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL--LPDR 290
Query: 782 -----SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFI 836
D D + + + KD G+Y A NS G ++ + V+EP P
Sbjct: 291 RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRP---- 346
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
Q++ +E G L +V + +P+ W+R ++ + P Q +G L+I +
Sbjct: 347 --LQDVEGREHGIAVLECKVPNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLK 403
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT- 955
++ D G Y C G+ A VT+ K +K L + + EG+ +L +T
Sbjct: 404 AD-DDGIYLC---EMRGRVRTVANVTV---KGPILKRLPRKLDVLEGENAVLLVETLEAG 456
Query: 956 VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVK-- 1013
V +W + +E+ + G D G + + + T+T+L VK
Sbjct: 457 VEGRWSRDGEELPVICQS---SSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCG 513
Query: 1014 -ETIPEFIRKLQDFEVKEKDVAIL---EVEINSETADVV-WERDGEIIKPKKNKYDFEKR 1068
+ P L + K+ +L E ET + ER + + EK
Sbjct: 514 VKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKA 573
Query: 1069 GHIRKLYIRNTSVHDEGEYS---CILRDESCTAEVTV---VELPP--EIITRLQNQKVNK 1120
G + + V EG+Y C + + V L P ++ L++ +V
Sbjct: 574 GAVE---VPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYD 630
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSN----------HIQLTIDGKKQKLKIYDCDL 1170
G A F ++L+ WF +G E++ + ++ G + +L ++
Sbjct: 631 GEDAVFSLDLST-IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKH 689
Query: 1171 DDAGE---YSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTD-AYLTVEIPDETLD 1226
D+G +SC + +A LT++E ++ L ++ LT E+
Sbjct: 690 QDSGALVGFSCP--GVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFP 747
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEF 1286
TWYK +E++E + D +K LI+ + D E+ C + V V +
Sbjct: 748 ATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAF--FGVTVQDP 805
Query: 1287 PPKIVDYEREYRIKRG--SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P IVD RE+ S+ +L W + + +++ +
Sbjct: 806 PVHIVD-PREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRR 864
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS----PPGKPNILEIDSSSINIC 1400
L + + +D G ++ + C + VTI D S P GK + + + +
Sbjct: 865 LVLPATQPSDGGEFQCVAGDECAY----FTVTITDVSSWIVYPSGKVYVAAVRLERVVLT 920
Query: 1401 WDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
+ + + + +E +++ + K T + + ++ S + + E+
Sbjct: 921 CELCRPWAE---VRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY----LCEI 973
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
D AS T + +I P E L +T E + L C P V WY+DG
Sbjct: 974 DDESASFTVTVTE--PPVRIIYPRDEVTLIAVTL---ECVVLMCELSREDAP-VRWYKDG 1027
Query: 1520 KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNED 1579
+++ ++A R D G+ V + P +
Sbjct: 1028 LEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAA 1087
Query: 1580 IKQKHKVGDEWLVTAVIEGIPP-PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
G V E P +V WYK+G ++E + + T + + +
Sbjct: 1088 RSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPE 1147
Query: 1639 HSSKYTIEASNTAGTSSVEVT------LKVYDKPS----KPEGPVIMR-EISRESVTIEW 1687
+ +Y E + A T +V + L + PS P PV++ E+SR + W
Sbjct: 1148 DAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVW 1207
Query: 1688 K---PPLDDG-GLEL 1698
P+ +G GLEL
Sbjct: 1208 SHNGRPVQEGEGLEL 1222
Score = 133 bits (321), Expect = 8e-30
Identities = 141/600 (23%), Positives = 243/600 (40%), Gaps = 36/600 (6%)
Query: 729 TGEKEPPQVIEPLK--SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSD 783
T ++ P ++ P S+ E V+L+ ++ P TW K+ + V+ L K D
Sbjct: 710 TIQESPVHILSPQDRVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKMD 768
Query: 784 GDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G H + IL KV+D G + + +EG++ V TV++P +P + F
Sbjct: 769 GRKHRL-ILPEAKVQDSGEFECR---TEGVSAFFGV-TVQDPPVHIVDPREHV--FVHAI 821
Query: 844 VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
E + L V R P + WY++ + + S+ + +G + LV+ D G+
Sbjct: 822 TSE--CVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPS-DGGE 877
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG-KTVILECQTSHT-VSTKWY 961
++CVA + + VTI V K Y + V+L C+ +W
Sbjct: 878 FQCVAGDECAYFT----VTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWT 933
Query: 962 HNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIR 1021
+ +E+ + +E D G C + D+ S + V E I
Sbjct: 934 KDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIY 993
Query: 1022 KLQDFEV--KEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNT 1079
+ + + +L E++ E A V W +DG ++ + E+ G +L +
Sbjct: 994 PRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVE-ESEALVLERDGPRCRLVLPAA 1052
Query: 1080 SVHDEGEYSCILRDESCTAEVTVVELPPEII---TRLQNQKVNKGNKATFEIELTKGDAL 1136
D GE+ C D+S VTV P I+ R + + E+ +
Sbjct: 1053 QPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQ 1112
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSI 1196
VRW+KDG E++ S+ +QL +G + L + +DAGEY CE + T + + EP +
Sbjct: 1113 VRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPV 1172
Query: 1197 NFTL--RLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLI 1254
F P + V L+ E+ V W +++ E L ++ +R L
Sbjct: 1173 QFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLC 1232
Query: 1255 IRKCTEDDQCEYTCVLLDAKSTTKLK--VEVVEFPPKIVDYE-REYRIKR--GSDVTLLV 1309
I+ YTC A L V+V E P ++V E + R++ G D+ L+V
Sbjct: 1233 IQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVV 1292
Score = 123 bits (297), Expect = 6e-27
Identities = 128/576 (22%), Positives = 223/576 (38%), Gaps = 33/576 (5%)
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTK--SDGDTHSITILKPKKVKDEGVYTLKA 807
E V+L+ ++ P + W K+ + V P DT +L +++D G Y +
Sbjct: 915 ERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI 973
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
++ S +TV EP P + +T++ + L+ ++R P + WY
Sbjct: 974 DDESA----SFTVTVTEPPVRIIYPRDEVTLIA-VTLE---CVVLMCELSREDAP-VRWY 1024
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
++ + SE + DG LV+ E D G++ C AG S VT+
Sbjct: 1025 KDGLEVEESEALVLERDGPRCRLVLPAAQPE-DGGEFVC----DAGDDSAFFTVTVTAPP 1079
Query: 928 VTFVKHLQKSYETEEGKT--VILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXX 984
V +S + G V L C+ + S +WY + E+ D ++ EG
Sbjct: 1080 ERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTL 1139
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILEVEIN 1041
D G C + + + +++ E +F+ V + +L E++
Sbjct: 1140 TLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELS 1199
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC----ILRDESCT 1097
A VVW +G ++ + + G R L I+ G Y+C S +
Sbjct: 1200 RAGAPVVWSHNGRPVQEGEG-LELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLS 1258
Query: 1098 AEVTVVELPPEIITRLQNQ---KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQL 1154
V V E P ++ Q + G + L+ VRW+KDG + +QL
Sbjct: 1259 FTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQL 1318
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
G +Q L++ DAGEY C+ +++VEEP + + + V DA
Sbjct: 1319 EQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDA 1378
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
E+ DVTW + +V+ + + + R L +R C D T L
Sbjct: 1379 TFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGD--AGTVTLRAGS 1436
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVD 1310
+ T ++ V E + ++ R + G DV L V+
Sbjct: 1437 TATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVE 1472
Score = 119 bits (287), Expect = 1e-25
Identities = 142/732 (19%), Positives = 280/732 (38%), Gaps = 40/732 (5%)
Query: 946 VILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ 1004
V+L C+ S WY + +++ + + +GR D G +C +
Sbjct: 735 VVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGV 794
Query: 1005 ETSTMLVVKETIPEFIRKLQDFEVKE--KDVAILEVEINSETADVVWERDGEIIKPKKNK 1062
+ V++ + + V + +L E++ E A V W +DG+ ++ + +
Sbjct: 795 SAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVE-ESDF 853
Query: 1063 YDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVN--K 1120
E G R+L + T D GE+ C+ DE VT+ ++ I+ V +
Sbjct: 854 VVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYVAAVR 913
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
+ EL + A VRW KDG E+ S + L + ++L + L+D+GEY CE+
Sbjct: 914 LERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI 973
Query: 1181 GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAY-LTVEIPDETLDVTWYKKKSVIEDT 1239
+ + +TV EP + E L+ + L E+ E V WYK +E++
Sbjct: 974 DDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVEES 1033
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYE--REY 1297
E L D + L++ +D E+ C DA + V PP+ + + R
Sbjct: 1034 EALVLERDGPRCRLVLPAAQPEDGGEFVC---DAGDDSAFFTVTVTAPPERIVHPAARSL 1090
Query: 1298 RIKRGSDVTLLVDYQAFPQPND-EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAG 1356
+ G+ + + + P + W + ++ + + + +LT+ + DAG
Sbjct: 1091 DLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1150
Query: 1357 IYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEP-----ENTGNST 1411
Y H + NV + + PP + LE S + + EP E +
Sbjct: 1151 EYVCETR----HEAITFNVILAE---PPVQFLALETTPSPLCVAPGEPVVLSCELSRAGA 1203
Query: 1412 IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
+ + + + E + + + + ++ Y + + + +
Sbjct: 1204 PVVWSHNGRPVQEGEGLELH--AEGPRRVLCIQAAGPAHAGLYTCQS-GAAPGAPSLSFT 1260
Query: 1472 KVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT-AKATYE 1530
+ E ++ E + + P D+EL G P V WY+DG++L + + E
Sbjct: 1261 VQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLE 1319
Query: 1531 N---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVG 1587
R Y C A D +V +++ ++ + +E G
Sbjct: 1320 QAGARQVLRVQGARSGDAGEYLCDAPQD----SRIFLVSVEEPLLVKLVSELTPLTVHEG 1375
Query: 1588 DEWLVTAVIEGIPPP-EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
D+ T E PP +V W +NG + + + + ++ ++ + + T+
Sbjct: 1376 DD--ATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLR 1433
Query: 1647 ASNTAGTSSVEV 1658
A +TA ++ + V
Sbjct: 1434 AGSTATSARLHV 1445
Score = 118 bits (284), Expect = 2e-25
Identities = 129/519 (24%), Positives = 212/519 (40%), Gaps = 59/519 (11%)
Query: 725 LKIKTGEK-EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPT 780
+K +G++ PP + + + V G L V+G P P + W K + + A L
Sbjct: 1 MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF 60
Query: 781 KSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE--------- 831
+DG H + +L D GVY +A N+ G A +A +TV EP + E
Sbjct: 61 PADGAEHGL-LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLP 119
Query: 832 -------PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN----NEIISPSETIT 880
P+F+ + V + L R P P++ W ++ +E+ S
Sbjct: 120 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 179
Query: 881 QNF---DGENIELVITNVDSEI-DSGDYKCVASNSAGKSSHGARVTI-----------DV 925
Q DG L + + + + DSG Y C A N+ G + GA + + D
Sbjct: 180 QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDE 239
Query: 926 EKVTFVKHLQ---KSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGR 980
V+ L+ K++ EGK C +W+ + + D R ++ R
Sbjct: 240 APAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP-DRRRLMYRDR 298
Query: 981 XXXXXXXXXX--XXDVGVIKCIVKDQETSTM----LVVKETIPEFIRKLQDFEVKEKDVA 1034
D G+ C ++ T+ L VKE F R LQD E +E +A
Sbjct: 299 DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIA 358
Query: 1035 ILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
+LE ++ + W R+ + + P + KY+ + G +R+L I D+G Y C +R
Sbjct: 359 VLECKVPNSRIPTAWFREDQRLLPCR-KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGR 417
Query: 1095 SCTAEVTVVELPPEIITRLQNQ-KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
T V+ P I+ RL + V +G A +E + RW +DG E+ I
Sbjct: 418 VRTVANVTVKGP--ILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---IC 472
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
+ G L + +DAGE + +GNS+ T +L V+
Sbjct: 473 QSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVK 511
Score = 101 bits (242), Expect = 3e-20
Identities = 142/651 (21%), Positives = 255/651 (39%), Gaps = 51/651 (7%)
Query: 651 ILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTV 710
++L C L P ++ W GEE+V + + E + L + V+ G Y +
Sbjct: 917 VVLTCELCR-PWAEVRWTKDGEEVVESPALLLQKEDTVRR----LVLPAVQLEDSGEY-L 970
Query: 711 VAVNREGEASLPIVLKIKTGEKEPP-QVIEPLK--SMIVRQGESVILSAQVVGNPRPTIT 767
++ E AS + + EPP ++I P ++I E V+L ++ P +
Sbjct: 971 CEIDDES-ASFTVTVT------EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VR 1022
Query: 768 WCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
W K+ V+ AL + DG + +L + +D G + A + +TV
Sbjct: 1023 WYKDGLEVEESEALVLERDGPRCRL-VLPAAQPEDGGEFVCDAGDDSAFF----TVTVTA 1077
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS-ITWYRNNEIISPSETITQNF 883
P E P R ++ G ++L V P S + WY++ + S+ +
Sbjct: 1078 PPERIVHPAA---RSLDLHFGAPGRVELRCEVA--PAGSQVRWYKDGLEVEASDALQLGA 1132
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV--KHLQKSYETE 941
+G L + + E D+G+Y C + A + V + V F+ +
Sbjct: 1133 EGPTRTLTLPHAQPE-DAGEYVCETRHEAITFN----VILAEPPVQFLALETTPSPLCVA 1187
Query: 942 EGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI 1000
G+ V+L C+ S W HN + + + E+ EG G+ C
Sbjct: 1188 PGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQ 1247
Query: 1001 V-----KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILE--VEINSETADVVWERDG 1053
+ T+ V + + + V+ LE V ++ V W +DG
Sbjct: 1248 SGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDG 1307
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVE-LPPEIITR 1112
E + + + E+ G + L ++ D GEY C +S V+V E L ++++
Sbjct: 1308 ERLA-SQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSE 1366
Query: 1113 LQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
L V++G+ ATF E++ DA V W ++G+ + +++ +G + L + C L D
Sbjct: 1367 LTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLGD 1426
Query: 1173 AGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI--PDETLDVTWY 1230
AG + G++ +A L V E + F RL + + D L VE V W
Sbjct: 1427 AGTVTLRAGSTATSARLHVRETELLFLRRLQD-VRAEEGQDVCLEVETGRVGAAGAVRWV 1485
Query: 1231 KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ + + ++ D L I DQ Y C ++ +L V
Sbjct: 1486 RGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSV 1536
Score = 93.5 bits (222), Expect = 7e-18
Identities = 153/748 (20%), Positives = 278/748 (37%), Gaps = 52/748 (6%)
Query: 651 ILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTV 710
++L C L + P W G+++ E + V ++ H L + K G +
Sbjct: 735 VVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHR----LILPEAKVQDSGEFEC 789
Query: 711 VAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ--GESVILSAQVVGNPRPTITW 768
EG ++ V T + P +++P + + V E V+L+ +V P + W
Sbjct: 790 ---RTEGVSAFFGV----TVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAP-VRW 841
Query: 769 CKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
K+ + V+ + +++G H +L + D G + A G +T+ +
Sbjct: 842 YKDGQEVEESDFVVLENEGP-HRRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDV 896
Query: 826 TEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
+ P + V+ + + L + R P + W ++ E + S + +
Sbjct: 897 SSWIVYPS---GKVYVAAVRLERVV-LTCELCR-PWAEVRWTKDGEEVVESPALLLQKED 951
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
LV+ V E DSG+Y C + + +S VT ++ + + + + +
Sbjct: 952 TVRRLVLPAVQLE-DSGEYLCEIDDES--ASFTVTVTEPPVRIIYPRD-EVTLIAVTLEC 1007
Query: 946 VILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ 1004
V+L C+ S +WY + E+ + + ++G D G C D
Sbjct: 1008 VVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDD 1067
Query: 1005 E---TSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKN 1061
T T+ E I + D L E+ + V W +DG ++ +
Sbjct: 1068 SAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS-D 1126
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEII---TRLQNQKV 1118
G R L + + D GEY C R E+ T V + E P + + T V
Sbjct: 1127 ALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCV 1186
Query: 1119 NKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC 1178
G EL++ A V W +G +Q ++L +G ++ L I AG Y+C
Sbjct: 1187 APGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTC 1246
Query: 1179 EVGNSKCTAILT----VEEPSINFTLRLPEFILVPANT--DAYLTVEIPDETLDVTWYKK 1232
+ G + L+ V EP + V + D L V + V WYK
Sbjct: 1247 QSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKD 1306
Query: 1233 KSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP--PKI 1290
+ + L ++ L ++ D EY C DA +++ + VE P K+
Sbjct: 1307 GERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC---DAPQDSRIFLVSVEEPLLVKL 1363
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKV 1350
V + G D T + P + W+ N ++ + + + S LT++
Sbjct: 1364 VSELTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGC 1422
Query: 1351 ENTDAGIYKLRLENNCGHADVEMNVTIL 1378
+ DAG LR + A + + T L
Sbjct: 1423 QLGDAGTVTLRAGSTATSARLHVRETEL 1450
Score = 76.6 bits (180), Expect = 9e-13
Identities = 128/619 (20%), Positives = 228/619 (36%), Gaps = 50/619 (8%)
Query: 1118 VNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLKIYDCDLDDAGE 1175
VN+G A F + K + + W +G + + D LK+ C D G
Sbjct: 257 VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 316
Query: 1176 YSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYK 1231
Y C NS + L V+EP + FT L + + + A L ++P+ + W++
Sbjct: 317 YVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQD-VEGREHGIAVLECKVPNSRIPTAWFR 375
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
+ + K+ I + R LII + DD Y C + + + V P +
Sbjct: 376 EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTVKGPILK 432
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
R+ + G + LLV+ W S+ ++ S +L + V
Sbjct: 433 RLPRKLDVLEGENAVLLVE-TLEAGVEGRW---SRDGEELPVICQSSSGHMHALVLPGVT 488
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI---DSSSINICWDEPENTG 1408
DAG L N+ + V K SPPG P + E+ +++ + W PE
Sbjct: 489 REDAGEVTFSLGNS--RTTTLLRVKCGVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAP 546
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKNITK---TQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
+ IY +E QE+ + +WI +I K + + + YRFR V S
Sbjct: 547 ETPFIYR-LERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTV-----SGHG 600
Query: 1466 ETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
+ + + + L+++ ED + + Q TW+ +G++LK+
Sbjct: 601 RSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFLNGEELKSN 658
Query: 1526 KATYE---NRXXXXXXXXXXXXXXXYKCIAFNDHGE--------VETSCVVGIQQKPVIT 1574
+ + + D G V+ S + IQ+ PV
Sbjct: 659 EPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHI 718
Query: 1575 ISNED-IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
+S +D + + ++T + + P WYK+G K+E + + + + +
Sbjct: 719 LSPQDRVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILP 777
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP---SKPEGPVIMREISRESVTIEWKPP 1690
E K S ++ T G S+ + V D P P V + I+ E V + +
Sbjct: 778 EAKVQDSGEF---ECRTEGVSAF-FGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVD 833
Query: 1691 LDDGGLELTKYAIEKHEPD 1709
+D + K E E D
Sbjct: 834 REDAPVRWYKDGQEVEESD 852
Score = 56.0 bits (129), Expect = 1e-06
Identities = 35/112 (31%), Positives = 53/112 (47%), Gaps = 5/112 (4%)
Query: 496 PVFEKPTSEEQSMAPIFVEKLR--PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIK 551
P P +++ AP+ VE L+ PK +G +F C V G P P+I W + +
Sbjct: 229 PPESPPADPDEAPAPV-VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 287
Query: 552 PSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
P + MY D D L + +D G + C A+N+AG S +L V+ P
Sbjct: 288 PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP 339
Score = 39.9 bits (89), Expect = 0.098
Identities = 42/231 (18%), Positives = 82/231 (35%), Gaps = 8/231 (3%)
Query: 1466 ETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
E + ++ E +Q +E + P E + L+C P V W +G+ ++
Sbjct: 1159 EAITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEG 1217
Query: 1526 KATYEN----RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNE--D 1579
+ + R Y C + G S V + + PV ++ E
Sbjct: 1218 EGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQ 1277
Query: 1580 IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSH 1639
+ + G + + + G P V WYK+G +L + + V+R++ +
Sbjct: 1278 TRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGD 1336
Query: 1640 SSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPP 1690
+ +Y +A + V V + K P+ + E + E PP
Sbjct: 1337 AGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPP 1387
>X64699-1|CAA45940.1| 531|Homo sapiens titin protein.
Length = 531
Score = 148 bits (359), Expect = 2e-34
Identities = 120/435 (27%), Positives = 190/435 (43%), Gaps = 30/435 (6%)
Query: 1282 EVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SI 1338
E +E P +D E + I+ G + L V + P P +W K+ + + +
Sbjct: 109 EKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW---GKVDGEIRDAAIIDV 165
Query: 1339 DSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
S SL + V D+G Y L LEN+ G + V +LD PSPP + EI S++
Sbjct: 166 TSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVS 225
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVN 1457
I W+ P G S I Y+VE +E + +V N K I L+ SY FR A N
Sbjct: 226 ITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAEN 285
Query: 1458 EVDISDASETTEYYKVIKETKIQSP-TVEKPLKNIT----TEPNEDIELTCIFGGVP-QP 1511
E I ++T + KV + + TV+ +N T+P D I V Q
Sbjct: 286 EYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQA 345
Query: 1512 KVTW-YRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET-SCVVGIQQ 1569
K + + + ++K+ +A N ++ +A N+ G + S V I
Sbjct: 346 KHSEKWSECARVKSLQAVITN--------LTQGEEYLFRVVAVNEKGRSDPRSLAVPIVA 397
Query: 1570 KPVITISNEDIKQKH-----KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTK 1624
K ++ D+K +VG + + I G P P + W K+G L+ N+T
Sbjct: 398 KDLVI--EPDVKPAFSSYSVQVGQDLKMEVPIFGRPKPTITWTKDGLPLKQTTRINVTDS 455
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + IKE + +Y I +N G + + + DKP P+GPV ++S ES+T
Sbjct: 456 LDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESIT 515
Query: 1685 IEWKPPLDDGGLELT 1699
+ W PPL GG ++T
Sbjct: 516 LSWNPPLYTGGCQIT 530
Score = 147 bits (355), Expect = 6e-34
Identities = 118/406 (29%), Positives = 183/406 (45%), Gaps = 19/406 (4%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
I+G P PEV W K ++ + ++T+ TS++ + + R S KYT+ N++GT S
Sbjct: 140 IKGRPTPEVKWGKVDGEIRDAAIIDVTSSF-TSLV-LDNVNRYDSGKYTLTLENSSGTKS 197
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
VT++V D PS P + + EI+++SV+I W+PPL DGG ++ Y +EK E +
Sbjct: 198 AFVTVRVLDTPSPPVN-LKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAA 256
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS-EALESEPIVIKTALDVPSXXXXXX 1774
V + ++ I +L E C Y FRV A+N G A ++PI + P
Sbjct: 257 VV-TNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPG----KI 311
Query: 1775 XXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXARIQKLSINT 1833
+ SV ++W E +GGS II Y VE++ + +KW A I L+
Sbjct: 312 TVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSLQAVITNLTQGE 371
Query: 1834 TYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNG 1893
Y FR+ A NE G S P + I + K L + S S LK P
Sbjct: 372 EYLFRVVAVNEKGRSDPRSLAVPI-VAKDLVIEPDVKPAFSSYSVQVGQDLKMEVPIFGR 430
Query: 1894 GSPITNYIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
P + + + K T+I VT + I+ + D + I+ N VG
Sbjct: 431 PKPTITWTKDGLPL--KQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVG-QKTA 487
Query: 1953 ESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPL 1998
+ V L+K P PP P++ V + + SW P + GG +
Sbjct: 488 SIEIVTLDK----PDPPKGPVKFDDVSAESITLSWNPPLYTGGCQI 529
Score = 146 bits (354), Expect = 8e-34
Identities = 109/393 (27%), Positives = 180/393 (45%), Gaps = 20/393 (5%)
Query: 1665 KPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE 1724
KP P P ++ +I+R SV + W P+ DGG E+ Y +EK + W +
Sbjct: 11 KPGPPNNPKVI-DITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINK 69
Query: 1725 TYC-IQKLNENCEYMFRVIAQNPVGFSEALESE-PIVIKTALDVPSXXXXXXXXXXID-N 1781
T ++KL E EY FR+ A N G E + PI+++ L+ P I+
Sbjct: 70 TNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIR 129
Query: 1782 ESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ F K +P + + + + ++ + ++ +
Sbjct: 130 AGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTL 189
Query: 1842 RNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
N GT + +T+ + L PS P N V+E T SV++ W P +GGS I NYI
Sbjct: 190 ENSSGTKSAF-----VTV-RVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYI 243
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHC--IENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
+E + KS+ +VT + H++ I+ ++E FR++AEN G+ LP +Q+
Sbjct: 244 VEKREATRKSYAAVVT---NCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLP--AQTADP 298
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKV 2019
K A VP PP + + V N V SW PE DGG+ ++ Y + ++ W E +
Sbjct: 299 IKVAEVPQPP-GKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECAR- 356
Query: 2020 DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
V +L+ I +L++ Y+ R+ A NE G S+P
Sbjct: 357 -VKSLQAVITNLTQGEEYLFRVVAVNEKGRSDP 388
Score = 114 bits (274), Expect = 4e-24
Identities = 127/542 (23%), Positives = 212/542 (39%), Gaps = 43/542 (7%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKT 1436
KP PP P +++I SS+ + W +P G I Y+VE ++ EW I KT
Sbjct: 11 KPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKT 70
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITT 1493
++ L Y FR A+N+ + + ++ +I E K+++P ++ L K I
Sbjct: 71 NIEVEKLLEKHEYNFRICAINKAGVGEHADVPG--PIIVEEKLEAPDIDLDLELRKIINI 128
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA--TYENRXXXXXXXXXXXXXXXYKCI 1551
+ L G P P+V W + +++ A + Y
Sbjct: 129 RAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLT 188
Query: 1552 AFNDHGEVETSCVVGI--QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKN 1609
N G V + P + + +I K V W + G I K
Sbjct: 189 LENSSGTKSAFVTVRVLDTPSPPVNLKVTEI-TKDSVSITWEPPLLDGGSKIKNYIVEKR 247
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT---LKVYDKP 1666
+T K S +I +L+ S + + A N G T +KV + P
Sbjct: 248 -EATRKSYAAVVTNCHKNS-WKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVP 305
Query: 1667 SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETY 1726
+P G + + +++R SV++ W P DGG ++ +Y +E + +W + A V + ++
Sbjct: 306 -QPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARV-KSLQA- 362
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNE--S 1783
I L + EY+FRV+A N G S+ + PIV K + P +
Sbjct: 363 VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLK 422
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXA-RIQKLSINTTY-----QF 1837
+ + F K P I + ++G K + + LSI T+ Q+
Sbjct: 423 MEVPIFGRPK----PTITW----TKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQY 474
Query: 1838 RIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPI 1897
I N +G S + +T+ K PP P F + ++ S+TL W P GG I
Sbjct: 475 GITVANVVGQKT--ASIEIVTLDKP-DPPKGPVKF--DDVSAESITLSWNPPLYTGGCQI 529
Query: 1898 TN 1899
TN
Sbjct: 530 TN 531
Score = 104 bits (250), Expect = 3e-21
Identities = 80/339 (23%), Positives = 141/339 (41%), Gaps = 10/339 (2%)
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVK 1249
+E P I+ L L + I + A L V I T +V W K I D + S
Sbjct: 111 LEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFT 170
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
+L++ D +YT L ++ T + V V++ P V+ + K +T
Sbjct: 171 --SLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITW 228
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCG 1367
+IV + + + + S I +++ + +++ EN G
Sbjct: 229 EPPLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYG 288
Query: 1368 ---HADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
A + + + P PPGK + ++ +S+++ W +PE+ G S II Y+VE Q +
Sbjct: 289 IGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHS 348
Query: 1425 TEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
+W + Q I NL Y FR AVNE SD ++ + + P V
Sbjct: 349 EKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLA--VPIVAKDLVIEPDV 406
Query: 1485 EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+ + + + +D+++ G P+P +TW +DG LK
Sbjct: 407 KPAFSSYSVQVGQDLKMEVPIFGRPKPTITWTKDGLPLK 445
Score = 62.5 bits (145), Expect = 2e-08
Identities = 82/391 (20%), Positives = 153/391 (39%), Gaps = 28/391 (7%)
Query: 1044 TADVVWER-DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT--AEV 1100
T +V W + DGEI ++ + L + N + +D G+Y+ L + S T A V
Sbjct: 145 TPEVKWGKVDGEI----RDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFV 200
Query: 1101 TVVELP-PEIITRLQNQKVNKGNKA-TFEIELTKGDALVR-WFKDGSEIQFSNHIQLTID 1157
TV L P L+ ++ K + + T+E L G + ++ + + E ++ + +
Sbjct: 201 TVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAAVVTN 260
Query: 1158 GKKQKLKI--------YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
K KI Y + EY + I E P + + + +
Sbjct: 261 CHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDD--VTR 318
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
+ T D + Y + + +EK++ + VK +I T+ ++ + V
Sbjct: 319 NSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVV 378
Query: 1270 LLDAKSTT---KLKVEVVE----FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
++ K + L V +V P + Y ++ G D+ + V P+P W
Sbjct: 379 AVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKMEVPIFGRPKPTITWT 438
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
+ +K+ + +L+IK+ D G Y + + N G + + LDKP
Sbjct: 439 KDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPD 498
Query: 1383 PP-GKPNILEIDSSSINICWDEPENTGNSTI 1412
PP G ++ + SI + W+ P TG I
Sbjct: 499 PPKGPVKFDDVSAESITLSWNPPLYTGGCQI 529
Score = 61.3 bits (142), Expect = 4e-08
Identities = 68/290 (23%), Positives = 119/290 (41%), Gaps = 18/290 (6%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVE-IKQEGKKWKXXX---XXXXXXARIQKLSINTT 1834
I SV+++W +GG I Y VE +W ++KL
Sbjct: 23 ITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHE 82
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE--STSRSVTLKWTEPESN 1892
Y FRI A N+ G I + + L P + + + + +L+ P
Sbjct: 83 YNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKG 142
Query: 1893 GGSPITNYIIEFKTVKGKSW-TKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLP 1951
+P +++ V G+ I+ V S ++N+ D + ++ EN+ G
Sbjct: 143 RPTPE----VKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSG---- 194
Query: 1952 TESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKT 2011
T+S V + T PSPP L++ + + V +W P DGG+ + Y + R+ T+
Sbjct: 195 TKSAFVTVRVLDT-PSPPVN-LKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREATRK 252
Query: 2012 MWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
+ V + + + I L E +Y R+ A NE G+ P ++ +P KV
Sbjct: 253 SYAAV-VTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKV 301
Score = 59.3 bits (137), Expect = 1e-07
Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 16/157 (10%)
Query: 697 ITNVKKFQEGTYTVVAVNREGEA-----SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
ITN+ + +E + VVAVN +G + ++PIV K E P V S V+ G+
Sbjct: 364 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIE---PDVKPAFSSYSVQVGQD 420
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV-KDE-GVYTLKAEN 809
+ + + G P+PTITW K+ P+K + D+ +T L K+ KD+ G Y + N
Sbjct: 421 LKMEVPIFGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVAN 480
Query: 810 SEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVK 845
G S ++T+++P +PP +F +++ +
Sbjct: 481 VVGQKTASIEIVTLDKP-----DPPKGPVKFDDVSAE 512
Score = 54.0 bits (124), Expect = 6e-06
Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMW-MEVGKVDVNTL 2024
P PP P I + S++ + SW P +DGG + GY + DV+ W M +N
Sbjct: 12 PGPPNNPKVIDITRSSVFL-SWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKT 70
Query: 2025 KFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADE 2071
+ L E H Y RI A N+ G+ E +D P +I E A +
Sbjct: 71 NIEVEKLLEKHEYNFRICAINKAGVGE--HADVPGPIIVEEKLEAPD 115
Score = 42.7 bits (96), Expect = 0.014
Identities = 37/154 (24%), Positives = 68/154 (44%), Gaps = 10/154 (6%)
Query: 695 LKITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
+++ + + E + + A+N+ G + PI+++ K + +E K + +R G
Sbjct: 72 IEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAG 131
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
S+ L + G P P + W K + ++ + + +L D G YTL EN
Sbjct: 132 GSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLEN 191
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
S G SA +TV + PP+ + + EIT
Sbjct: 192 SSG--TKSAFVTVR--VLDTPSPPVNL-KVTEIT 220
Score = 39.1 bits (87), Expect = 0.17
Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G ++ E + G P+P ITW + +K + + D ++ TL I+E +D G +
Sbjct: 418 GQDLKMEVPIFGRPKPTITWTKDGLPLKQTTRINVT-DSLDLTTLSIKETHKDDGGQYGI 476
Query: 584 VAKNAAGFASSTTELI 599
N G +++ E++
Sbjct: 477 TVANVVGQKTASIEIV 492
Score = 37.9 bits (84), Expect = 0.39
Identities = 37/131 (28%), Positives = 59/131 (45%), Gaps = 9/131 (6%)
Query: 798 KDEGVYTLKAENSEGIAETSAV---ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
K E + + A N G+ E + V I VEE E + L + + I ++ G+++L
Sbjct: 80 KHEYNFRICAINKAGVGEHADVPGPIIVEEKLEA-PDIDLDLELRKIINIRAGGSLRLFV 138
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+ P P + W + + I + I + LV+ NV + DSG Y NS+G
Sbjct: 139 PIKGRPTPEVKWGKVDGEIRDAAII--DVTSSFTSLVLDNV-NRYDSGKYTLTLENSSGT 195
Query: 915 SSHGARVTIDV 925
S A VT+ V
Sbjct: 196 KS--AFVTVRV 204
Score = 33.5 bits (73), Expect = 8.5
Identities = 29/111 (26%), Positives = 47/111 (42%), Gaps = 8/111 (7%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V G D+ +E + P+P I W G + I+V D+ + L I K
Sbjct: 415 VQVGQDLKMEVPIFGRPKPTITWTKDGLPLKQTTRINVTDSLDL----TTLSIKETHKDD 470
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
G Y + N G+ + I + + + +PP+ P+K V ES+ LS
Sbjct: 471 GGQYGITVANVVGQKTASIEI-VTLDKPDPPK--GPVKFDDV-SAESITLS 517
>BC007201-1|AAH07201.1| 1044|Homo sapiens OBSL1 protein protein.
Length = 1044
Score = 147 bits (356), Expect = 4e-34
Identities = 188/821 (22%), Positives = 328/821 (39%), Gaps = 86/821 (10%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K +S +Q P F+ RP G+ + +C V G P P + W + + S+ +
Sbjct: 21 KASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLS-F 79
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFA-SSTTELIVEAPLSDHGSEMTVXXXXX 618
D L++ P DAG + C A+NAAG A ++ ++E P SD E+
Sbjct: 80 PADGAEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASD--PELQPAERPL 137
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKG---EEIV 675
EG P F P++Q+V G++++L CR +PEP + W G +E+
Sbjct: 138 PSPGSG-----EG-APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVW 191
Query: 676 PDENISV--AIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKE 733
+ ++ D L+I + G Y A N G A +L++ +
Sbjct: 192 DSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPES 251
Query: 734 PP--------QVIEPL----KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK 781
PP V+EPL K+ V +G+ V+G P P I W +P+ LP +
Sbjct: 252 PPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL--LPDR 309
Query: 782 -----SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFI 836
D D + + + KD G+Y A NS G ++ + V+EP P
Sbjct: 310 RRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRP---- 365
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
Q++ +E G L +V + +P+ W+R ++ + P Q +G L+I +
Sbjct: 366 --LQDVEGREHGIAVLECKVPNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLK 422
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT- 955
++ D G Y C G+ A VT+ K +K L + + EG+ +L +T
Sbjct: 423 AD-DDGIYLC---EMRGRVRTVANVTV---KGPILKRLPRKLDVLEGENAVLLVETLEAG 475
Query: 956 VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVK-- 1013
V +W + +E+ + G D G + + + T+T+L VK
Sbjct: 476 VEGRWSRDGEELPVICQS---SSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCV 532
Query: 1014 ETIPEFIRKLQDFEVKEKDVAIL---EVEINSETADVV-WERDGEIIKPKKNKYDFEKRG 1069
+ P L + K+ +L E ET + ER + + EK G
Sbjct: 533 KHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAG 592
Query: 1070 HIRKLYIRNTSVHDEGEYS---CILRDESCTAEVTV---VELPP--EIITRLQNQKVNKG 1121
+ + V EG+Y C + + V L P ++ L++ +V G
Sbjct: 593 AVE---VPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDG 649
Query: 1122 NKATFEIELTKGDALVRWFKDGSEIQFSN----------HIQLTIDGKKQKLKIYDCDLD 1171
A F ++L+ WF +G E++ + ++ G + +L ++
Sbjct: 650 EDAVFSLDLST-IIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQ 708
Query: 1172 DAGE---YSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTD-AYLTVEIPDETLDV 1227
D+G +SC + +A LT++E ++ + L ++ LT E+
Sbjct: 709 DSGALVGFSCP--GVQDSAALTIQESPVHILSPQDKVSLTFTTSERVVLTCELSRVDFPA 766
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC 1268
TWYK +E++E + D +K LI+ + D E+ C
Sbjct: 767 TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFEC 807
Score = 120 bits (289), Expect = 6e-26
Identities = 172/802 (21%), Positives = 316/802 (39%), Gaps = 83/802 (10%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY------DD 562
AP+F+ R + G+ V C+ G P P + W + + D + +D
Sbjct: 146 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 205
Query: 563 DNVATLVIREVFPE--DAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
A+L +R + D+G + C A+NA G A + L V P ++
Sbjct: 206 GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPD-------- 257
Query: 621 XXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI 680
A ++E + PK +V+EG C ++ PEP+I W ++G ++PD
Sbjct: 258 --EAPAPVVEPLKCA----PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRR 311
Query: 681 SVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP-QVIE 739
+ + D VLK+ + G Y A N G+ + L +K EP +
Sbjct: 312 LMYRDRDGGF---VLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK----EPRLRFTR 364
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKK 796
PL+ + R+ +L +V + PT W + ++ P + +G + I+ K
Sbjct: 365 PLQDVEGREHGIAVLECKVPNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRL-IIHRLK 422
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D+G+Y + G T A +TV+ P+ +++ V E L+
Sbjct: 423 ADDDGIYLCEMR---GRVRTVANVTVKG--------PILKRLPRKLDVLEGENAVLLVET 471
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
V W R+ E + I Q+ G LV+ V E D+G+ NS +++
Sbjct: 472 LEAGVEG-RWSRDGEELP---VICQSSSGHMHALVLPGVTRE-DAGEVTFSLGNS--RTT 524
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHN--KKEISGMDHRE 974
RV L + ++ + ++ T + + ++E+ D +
Sbjct: 525 TLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQ 584
Query: 975 ---IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKET---IP--EFIRKLQDF 1026
I + G D C V S +V + +P + L+D
Sbjct: 585 CFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDV 644
Query: 1027 EVKEKDVAILEVEINSETADVVWERDGEIIK---------PKKNKYDFEKRGHIRKLYIR 1077
+V + + A+ +++ S W +GE +K P +Y E++G +L +
Sbjct: 645 QVYDGEDAVFSLDL-STIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILH 703
Query: 1078 NTSVHDEGE---YSCILRDESCTAEVTVVELPPEIITRLQNQKVN--KGNKATFEIELTK 1132
D G +SC +S A +T+ E P I++ + + EL++
Sbjct: 704 AVKHQDSGALVGFSCPGVQDS--AALTIQESPVHILSPQDKVSLTFTTSERVVLTCELSR 761
Query: 1133 GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
D W+KDG +++ S + + +DG+K +L + + + D+GE+ C +TV+
Sbjct: 762 VDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQ 821
Query: 1193 EPSINFTLRLPEFILVPANTD--AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKK 1250
+P ++ + E + V A T L E+ E V WYK +E+++ L ++
Sbjct: 822 DPPVHI-VDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPH 880
Query: 1251 RTLIIRKCTEDDQCEYTCVLLD 1272
R L++ D E+ CV D
Sbjct: 881 RRLVLPATQPSDGGEFQCVAGD 902
Score = 118 bits (284), Expect = 2e-25
Identities = 129/519 (24%), Positives = 212/519 (40%), Gaps = 59/519 (11%)
Query: 725 LKIKTGEK-EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPT 780
+K +G++ PP + + + V G L V+G P P + W K + + A L
Sbjct: 20 MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF 79
Query: 781 KSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE--------- 831
+DG H + +L D GVY +A N+ G A +A +TV EP + E
Sbjct: 80 PADGAEHGL-LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLP 138
Query: 832 -------PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN----NEIISPSETIT 880
P+F+ + V + L R P P++ W ++ +E+ S
Sbjct: 139 SPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFAL 198
Query: 881 QNF---DGENIELVITNVDSEI-DSGDYKCVASNSAGKSSHGARVTI-----------DV 925
Q DG L + + + + DSG Y C A N+ G + GA + + D
Sbjct: 199 QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDE 258
Query: 926 EKVTFVKHLQ---KSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGR 980
V+ L+ K++ EGK C +W+ + + D R ++ R
Sbjct: 259 APAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP-DRRRLMYRDR 317
Query: 981 XXXXXXXXXX--XXDVGVIKCIVKDQETSTM----LVVKETIPEFIRKLQDFEVKEKDVA 1034
D G+ C ++ T+ L VKE F R LQD E +E +A
Sbjct: 318 DGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIA 377
Query: 1035 ILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
+LE ++ + W R+ + + P + KY+ + G +R+L I D+G Y C +R
Sbjct: 378 VLECKVPNSRIPTAWFREDQRLLPCR-KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGR 436
Query: 1095 SCTAEVTVVELPPEIITRLQNQ-KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
T V+ P I+ RL + V +G A +E + RW +DG E+ I
Sbjct: 437 VRTVANVTVKGP--ILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---IC 491
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
+ G L + +DAGE + +GNS+ T +L V+
Sbjct: 492 QSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVK 530
Score = 86.6 bits (205), Expect = 9e-16
Identities = 122/569 (21%), Positives = 219/569 (38%), Gaps = 50/569 (8%)
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEG 801
+ + V +GE+ +L + + W ++ + + + S G H++ +L +D G
Sbjct: 455 RKLDVLEGENAVLLVETL-EAGVEGRWSRDGEELPVICQSSSGHMHAL-VLPGVTREDAG 512
Query: 802 VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPV 861
T NS T+ ++ V+ PP+ F+ K T+ L + P
Sbjct: 513 EVTFSLGNSR----TTTLLRVKCVKHSPPGPPILAEMFKG----HKNTVLLTWKPPE-PA 563
Query: 862 PSITW-YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK---CVASNSAGKSSH 917
P + YR SE Q F E V D GDY+ C S G+S H
Sbjct: 564 PETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGH-GRSPH 622
Query: 918 ----GARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEIS----- 968
G+ + ++ V L+ + +G+ + S + W+ N +E+
Sbjct: 623 VVFHGSAHLVPTARL--VAGLE-DVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPE 679
Query: 969 -----GMDHREIIQEGRXXXXXXXXXXXXDVG-VIKCIVKDQETSTMLVVKETIPEFIRK 1022
G I Q+G D G ++ + S L ++E+ P I
Sbjct: 680 GQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQES-PVHILS 738
Query: 1023 LQD-----FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
QD F E+ +L E++ W +DG+ ++ + + G +L +
Sbjct: 739 PQDKVSLTFTTSER--VVLTCELSRVDFPATWYKDGQKVE-ESELLVVKMDGRKHRLILP 795
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNK--GNKATFEIELTKGDA 1135
V D GE+ C S VTV + P I+ ++ V+ E+ + DA
Sbjct: 796 EAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDA 855
Query: 1136 LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPS 1195
VRW+KDG E++ S+ + L +G ++L + D GE+ C G+ +C A TV
Sbjct: 856 PVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGD-EC-AYFTVTITD 913
Query: 1196 INFTLRLPE---FILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT 1252
++ + P ++ LT E+ +V W K + ++ L + R
Sbjct: 914 VSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRR 973
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
L++ +D EY C + D ++ + V
Sbjct: 974 LVLPAVQLEDSGEYLCEIDDESASFTVTV 1002
Score = 79.4 bits (187), Expect = 1e-13
Identities = 65/281 (23%), Positives = 117/281 (41%), Gaps = 7/281 (2%)
Query: 919 ARVTIDVEKVTFVKHLQK-SYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREII 976
A +TI V + K S + V+L C+ S WY + +++ + +
Sbjct: 725 AALTIQESPVHILSPQDKVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVK 784
Query: 977 QEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKE--KDVA 1034
+GR D G +C + + V++ + + V +
Sbjct: 785 MDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECV 844
Query: 1035 ILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
+L E++ E A V W +DG+ ++ + + E G R+L + T D GE+ C+ DE
Sbjct: 845 MLACEVDREDAPVRWYKDGQEVE-ESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDE 903
Query: 1095 SCTAEVTVVELPPEIITRLQNQKVN--KGNKATFEIELTKGDALVRWFKDGSEIQFSNHI 1152
VT+ ++ I+ V + + EL + A VRW KDG E+ S +
Sbjct: 904 CAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPAL 963
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
L + ++L + L+D+GEY CE+ + + +TV E
Sbjct: 964 LLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTE 1004
Score = 76.6 bits (180), Expect = 9e-13
Identities = 77/319 (24%), Positives = 135/319 (42%), Gaps = 20/319 (6%)
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
IL K +D G L + G+ + SA +T++E P ++ +T +
Sbjct: 701 ILHAVKHQDSGA--LVGFSCPGVQD-SAALTIQESPVHILSPQDKVS----LTFTTSERV 753
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
L ++R P+ TWY++ + + SE + DG L++ + DSG+++C
Sbjct: 754 VLTCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQ-DSGEFEC---R 808
Query: 911 SAGKSSHGARVTIDVEKVTFVKHLQKSY-ETEEGKTVILECQTS-HTVSTKWYHNKKEIS 968
+ G S+ VT+ V V + + + V+L C+ +WY + +E+
Sbjct: 809 TEGVSAFFG-VTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVE 867
Query: 969 GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQD 1025
D + EG D G +C+ D+ T T+ V I K+
Sbjct: 868 ESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYV 927
Query: 1026 FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEG 1085
V+ + V +L E+ A+V W +DGE + + +K +R+L + + D G
Sbjct: 928 AAVRLERV-VLTCELCRPWAEVRWTKDGEEV-VESPALLLQKEDTVRRLVLPAVQLEDSG 985
Query: 1086 EYSCILRDESCTAEVTVVE 1104
EY C + DES + VTV E
Sbjct: 986 EYLCEIDDESASFTVTVTE 1004
Score = 75.4 bits (177), Expect = 2e-12
Identities = 128/619 (20%), Positives = 229/619 (36%), Gaps = 51/619 (8%)
Query: 1118 VNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLKIYDCDLDDAGE 1175
VN+G A F + K + + W +G + + D LK+ C D G
Sbjct: 276 VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 335
Query: 1176 YSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYK 1231
Y C NS + L V+EP + FT L + + + A L ++P+ + W++
Sbjct: 336 YVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQD-VEGREHGIAVLECKVPNSRIPTAWFR 394
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
+ + K+ I + R LII + DD Y C + + + V P +
Sbjct: 395 EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTVKGPILK 451
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
R+ + G + LLV+ W S+ ++ S +L + V
Sbjct: 452 RLPRKLDVLEGENAVLLVE-TLEAGVEGRW---SRDGEELPVICQSSSGHMHALVLPGVT 507
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI---DSSSINICWDEPENTG 1408
DAG L N+ + V + K SPPG P + E+ +++ + W PE
Sbjct: 508 REDAGEVTFSLGNS--RTTTLLRVKCV-KHSPPGPPILAEMFKGHKNTVLLTWKPPEPAP 564
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKNITK---TQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
+ IY +E QE+ + +WI +I K + + + YRFR V S
Sbjct: 565 ETPFIYR-LERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTV-----SGHG 618
Query: 1466 ETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
+ + + + L+++ ED + + Q TW+ +G++LK+
Sbjct: 619 RSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG--TWFLNGEELKSN 676
Query: 1526 KATYE---NRXXXXXXXXXXXXXXXYKCIAFNDHGE--------VETSCVVGIQQKPVIT 1574
+ + + D G V+ S + IQ+ PV
Sbjct: 677 EPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHI 736
Query: 1575 ISNED-IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
+S +D + + ++T + + P WYK+G K+E + + + + +
Sbjct: 737 LSPQDKVSLTFTTSERVVLTCELSRVDFP-ATWYKDGQKVEESELLVVKMDGRKHRLILP 795
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP---SKPEGPVIMREISRESVTIEWKPP 1690
E K S ++ T G S+ + V D P P V + I+ E V + +
Sbjct: 796 EAKVQDSGEF---ECRTEGVSAF-FGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVD 851
Query: 1691 LDDGGLELTKYAIEKHEPD 1709
+D + K E E D
Sbjct: 852 REDAPVRWYKDGQEVEESD 870
Score = 56.0 bits (129), Expect = 1e-06
Identities = 35/112 (31%), Positives = 53/112 (47%), Gaps = 5/112 (4%)
Query: 496 PVFEKPTSEEQSMAPIFVEKLR--PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIK 551
P P +++ AP+ VE L+ PK +G +F C V G P P+I W + +
Sbjct: 248 PPESPPADPDEAPAPV-VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 306
Query: 552 PSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
P + MY D D L + +D G + C A+N+AG S +L V+ P
Sbjct: 307 PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP 358
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/96 (25%), Positives = 37/96 (38%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP + + R R+ G++ L P P W + + + D L
Sbjct: 30 PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLL 89
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
+ TDAG+Y R N G A VT+L+ P+
Sbjct: 90 LTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPA 125
Score = 36.3 bits (80), Expect = 1.2
Identities = 22/85 (25%), Positives = 35/85 (41%), Gaps = 1/85 (1%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G E + V+ G PPP V+W K G +L + + + + + + Y
Sbjct: 45 GAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYVCR 104
Query: 1647 ASNTAGTSSVEVTLKVYDKP-SKPE 1670
A N AG + + V + P S PE
Sbjct: 105 ARNAAGEAYAAAAVTVLEPPASDPE 129
>AL832379-1|CAD91155.1| 1045|Homo sapiens hypothetical protein
protein.
Length = 1045
Score = 147 bits (355), Expect = 6e-34
Identities = 98/375 (26%), Positives = 179/375 (47%), Gaps = 17/375 (4%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
Q LM+E + + + ++E D++ E PT + +APIF ++L+ +GS V F C
Sbjct: 635 QRLMNEIEF-RLERTPVDESDDEIQHDEIPTGK--CIAPIFDKRLKHFRVTEGSPVTFTC 691
Query: 532 QVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
++ G P P++ WF+ I K ++ +M + D +L I +D G +T +A N G
Sbjct: 692 KIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 751
Query: 591 FASSTTELIVEA-PLSDHGSEMTVXXXXXXXXXXXXADILEG--IPPTFSKKPKAQYVDE 647
S + L+V++ P+ + + L+ P F + P E
Sbjct: 752 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQTPGDMVAHE 811
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI-ESDMHMYCSVLKITNVKKFQEG 706
G L+C++ +P P++ WL G+ ++PD + + + E+ +H L I + + G
Sbjct: 812 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS----LLIDPLTQRDAG 867
Query: 707 TYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
TY +A N+ G+ S + L + E K+ P ++E L++ V +G V L +V+G P P
Sbjct: 868 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 927
Query: 766 ITWCKNNKPV----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
W K+N+ + + + D ++ +++P K D G YTL A+N GI +A +
Sbjct: 928 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLD 987
Query: 822 VEEPTEENAEPPLFI 836
+ PP+ +
Sbjct: 988 IYAQWHHQIPPPMSV 1002
Score = 96.3 bits (229), Expect = 1e-18
Identities = 91/329 (27%), Positives = 141/329 (42%), Gaps = 45/329 (13%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHM 690
I P F K+ K V EGS + C++V IP P + W G++I +E+ + E D
Sbjct: 668 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT- 726
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS---------LPIVLKIKTG----------- 730
CS L I + +G YT++A N +G S LPI ++ +
Sbjct: 727 -CS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 784
Query: 731 --EKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK 781
+KEP P ++ M+ +G L +V G P P +TW N +PV LP
Sbjct: 785 ERDKEPLQERFFRPHFLQTPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV--LPDA 842
Query: 782 S------DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLF 835
S + HS+ ++ P +D G Y A N G + S + + +E + P+
Sbjct: 843 SHKMLVRETGVHSL-LIDPLTQRDAGTYKCIATNKTG--QNSFSLELSVVAKEVKKAPVI 899
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII-SPSETITQNFDGENIELVITN 894
+ + Q V E ++L RV P P W ++NE I E I+ + D ++
Sbjct: 900 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 959
Query: 895 VDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ D+G Y A N AG S AR+ I
Sbjct: 960 PAKKSDAGWYTLSAKNEAGIVSCTARLDI 988
Score = 84.2 bits (199), Expect = 5e-15
Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 9/142 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY-------D 561
AP+F + L+ +G V FEC+V+G P P++ W+R+ +I+ S DF++ +
Sbjct: 159 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 218
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXX 619
+ + TLVI EVF ED+G FTC A N G SS +L V LS++GS +
Sbjct: 219 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL 278
Query: 620 XXXXXXADILEGIPPTFSKKPK 641
PP+ + PK
Sbjct: 279 AAIEPQPSPPHSEPPSVEQPPK 300
Score = 68.5 bits (160), Expect = 2e-10
Identities = 58/259 (22%), Positives = 108/259 (41%), Gaps = 33/259 (12%)
Query: 726 KIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTK 781
+I TG+ P + LK V +G V + ++VG P P + W K+ K + +
Sbjct: 661 EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMR 720
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE------------------ 823
+GD ++ D+G YT+ A N +G S + V+
Sbjct: 721 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 780
Query: 824 --------EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
EP +E P F+ ++ E +L +V+ P P +TW N + + P
Sbjct: 781 SRVQERDKEPLQERFFRPHFLQTPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 840
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI---DVEKVTFVK 932
+ + ++ + ++ D+G YKC+A+N G++S +++ +V+K +
Sbjct: 841 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL 900
Query: 933 HLQKSYETEEGKTVILECQ 951
++ EG V LEC+
Sbjct: 901 EKLQNCGVPEGHPVRLECR 919
Score = 50.8 bits (116), Expect = 5e-05
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 18/177 (10%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKK-LKTAKATYENRXXXXXXXX----XXXXXXXYKCIAFND 1555
L C G+P P++TW +G+ L A R YKCIA N
Sbjct: 817 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 876
Query: 1556 HGE----VETSCVVG-IQQKPVIT--ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK 1608
G+ +E S V +++ PVI + N + + H V E V G+PPP W K
Sbjct: 877 TGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI----GMPPPVFYWKK 932
Query: 1609 NGNKLENDKEYNITTKEKT--SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+ + +E ++ T + + I+ K+S + YT+ A N AG S L +Y
Sbjct: 933 DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIY 989
Score = 43.6 bits (98), Expect = 0.008
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G+PPPE+ W NG + D + + +E + I L + + Y A+N G +
Sbjct: 821 VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN 880
Query: 1655 SVEVTLKVYDKPSKPEGPVIMREI 1678
S + L V K K + PVI+ ++
Sbjct: 881 SFSLELSVVAKEVK-KAPVILEKL 903
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/99 (33%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQN-----FDG 885
P+F Q ++ E + RV P P + WYR +I SP I Q +
Sbjct: 160 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 219
Query: 886 ENI-ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E I LVI V +E DSG + C ASN G S A++ +
Sbjct: 220 EEICTLVIAEVFAE-DSGCFTCTASNKYGTVSSIAQLHV 257
Score = 42.7 bits (96), Expect = 0.014
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 1463 DASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
D S+ + I K +P +K LK+ + TC G+P PKV W++DGK++
Sbjct: 651 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 710
Score = 39.9 bits (89), Expect = 0.098
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNT 1650
T I GIP P+V W+K+G ++ E+ +E T + I+ YTI A+N
Sbjct: 690 TCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANP 749
Query: 1651 AGTSSVEVTLKVYDKP 1666
G S L V P
Sbjct: 750 QGRISCSGHLMVQSLP 765
Score = 38.3 bits (85), Expect = 0.30
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
I +P K L+N++ + + C G P PKV WYR+G
Sbjct: 157 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG 197
Score = 37.9 bits (84), Expect = 0.39
Identities = 21/68 (30%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 543 WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
W+ + ++ S D + N+ +L I E F ED G ++C A N G S++ E+ +E
Sbjct: 27 WYCEGKELENSPDIHIV-QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 85
Query: 603 PLSDHGSE 610
+S SE
Sbjct: 86 -VSSSDSE 92
Score = 37.1 bits (82), Expect = 0.69
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 11/113 (9%)
Query: 1561 TSCVVGIQQKPVITISN-EDIKQKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDK 1617
T+ + G+ KP+I + Q + LV ++G P P+V WY+ G +E+
Sbjct: 145 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 204
Query: 1618 EYNITTK--------EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ I K E+ + I E+ S +T ASN GT S L V
Sbjct: 205 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 257
Score = 36.3 bits (80), Expect = 1.2
Identities = 45/191 (23%), Positives = 77/191 (40%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D E + L+ +++ ++ W +G+ + P + + + L
Sbjct: 798 PHFLQTPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 857
Query: 1076 IRNTSVHDEGEYSCILRDE----SCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y CI ++ S + E++V V+ P I+ +LQN V +G+ E
Sbjct: 858 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 917
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQK-LKIYDCDLDDAGEYSC----EV 1180
+ + W KD I + I + D L I DAG Y+ E
Sbjct: 918 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 977
Query: 1181 GNSKCTAILTV 1191
G CTA L +
Sbjct: 978 GIVSCTARLDI 988
Score = 35.9 bits (79), Expect = 1.6
Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 4/102 (3%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM--- 690
P F+K + EG ++ ECR+ P P + W +G I + + + M
Sbjct: 160 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 219
Query: 691 -YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE 731
L I V G +T A N+ G S L ++ E
Sbjct: 220 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 261
Score = 35.1 bits (77), Expect = 2.8
Identities = 21/77 (27%), Positives = 33/77 (42%), Gaps = 1/77 (1%)
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD 1664
+WY G +LEN + +I + I E + +Y+ ASN GT S + +
Sbjct: 26 MWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 85
Query: 1665 -KPSKPEGPVIMREISR 1680
S EG E++R
Sbjct: 86 VSSSDSEGDPNKEEMNR 102
Score = 33.9 bits (74), Expect = 6.4
Identities = 24/81 (29%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSN-HIQLTIDGKKQ- 1161
+ P RL++ +V +G+ TF ++ V WFKDG +I N H ++ +G
Sbjct: 668 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 727
Query: 1162 KLKIYDCDLDDAGEYSCEVGN 1182
L I DD G Y+ N
Sbjct: 728 SLHIESTTSDDDGNYTIMAAN 748
>AL832002-1|CAD89906.1| 1320|Homo sapiens hypothetical protein
protein.
Length = 1320
Score = 147 bits (355), Expect = 6e-34
Identities = 98/375 (26%), Positives = 179/375 (47%), Gaps = 17/375 (4%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
Q LM+E + + + ++E D++ E PT + +APIF ++L+ +GS V F C
Sbjct: 910 QRLMNEIEF-RLERTPVDESDDEIQHDEIPTGK--CIAPIFDKRLKHFRVTEGSPVTFTC 966
Query: 532 QVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
++ G P P++ WF+ I K ++ +M + D +L I +D G +T +A N G
Sbjct: 967 KIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
Query: 591 FASSTTELIVEA-PLSDHGSEMTVXXXXXXXXXXXXADILEG--IPPTFSKKPKAQYVDE 647
S + L+V++ P+ + + L+ P F + P E
Sbjct: 1027 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHE 1086
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI-ESDMHMYCSVLKITNVKKFQEG 706
G L+C++ +P P++ WL G+ ++PD + + + E+ +H L I + + G
Sbjct: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS----LLIDPLTQRDAG 1142
Query: 707 TYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
TY +A N+ G+ S + L + E K+ P ++E L++ V +G V L +V+G P P
Sbjct: 1143 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 1202
Query: 766 ITWCKNNKPV----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
W K+N+ + + + D ++ +++P K D G YTL A+N GI +A +
Sbjct: 1203 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLD 1262
Query: 822 VEEPTEENAEPPLFI 836
+ PP+ +
Sbjct: 1263 IYAQWHHQIPPPMSV 1277
Score = 96.3 bits (229), Expect = 1e-18
Identities = 91/329 (27%), Positives = 141/329 (42%), Gaps = 45/329 (13%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHM 690
I P F K+ K V EGS + C++V IP P + W G++I +E+ + E D
Sbjct: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT- 1001
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS---------LPIVLKIKTG----------- 730
CS L I + +G YT++A N +G S LPI ++ +
Sbjct: 1002 -CS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
Query: 731 --EKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK 781
+KEP P ++ M+ +G L +V G P P +TW N +PV LP
Sbjct: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV--LPDA 1117
Query: 782 S------DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLF 835
S + HS+ ++ P +D G Y A N G + S + + +E + P+
Sbjct: 1118 SHKMLVRETGVHSL-LIDPLTQRDAGTYKCIATNKTG--QNSFSLELSVVAKEVKKAPVI 1174
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII-SPSETITQNFDGENIELVITN 894
+ + Q V E ++L RV P P W ++NE I E I+ + D ++
Sbjct: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
Query: 895 VDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ D+G Y A N AG S AR+ I
Sbjct: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
Score = 81.0 bits (191), Expect = 4e-14
Identities = 46/142 (32%), Positives = 70/142 (49%), Gaps = 9/142 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-------YYD 561
AP+F + L+ +G V FEC+V+G P P++ W+R+ +I+ S DF++ +
Sbjct: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRISQKKPRSMAE 493
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXX 619
+ + TLVI EVF E +G FTC A N G SS +L V LS++GS +
Sbjct: 494 PEEICTLVIAEVFAEGSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL 553
Query: 620 XXXXXXADILEGIPPTFSKKPK 641
PP+ + PK
Sbjct: 554 AAIEPQPSPPHSEPPSVEQPPK 575
Score = 72.5 bits (170), Expect = 1e-11
Identities = 37/107 (34%), Positives = 57/107 (53%), Gaps = 2/107 (1%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
E P F +KLR + P+G+ VQ +C V G P PQ+ W+ + ++ S D +
Sbjct: 263 EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI-VQAG 321
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSE 610
N+ +L I E F ED G ++C A N G S++ E+ +E +S SE
Sbjct: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG-VSSSDSE 367
Score = 68.5 bits (160), Expect = 2e-10
Identities = 58/259 (22%), Positives = 108/259 (41%), Gaps = 33/259 (12%)
Query: 726 KIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTK 781
+I TG+ P + LK V +G V + ++VG P P + W K+ K + +
Sbjct: 936 EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMR 995
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE------------------ 823
+GD ++ D+G YT+ A N +G S + V+
Sbjct: 996 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 1055
Query: 824 --------EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
EP +E P F+ ++ E +L +V+ P P +TW N + + P
Sbjct: 1056 SRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1115
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI---DVEKVTFVK 932
+ + ++ + ++ D+G YKC+A+N G++S +++ +V+K +
Sbjct: 1116 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL 1175
Query: 933 HLQKSYETEEGKTVILECQ 951
++ EG V LEC+
Sbjct: 1176 EKLQNCGVPEGHPVRLECR 1194
Score = 50.8 bits (116), Expect = 5e-05
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 18/177 (10%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKK-LKTAKATYENRXXXXXXXX----XXXXXXXYKCIAFND 1555
L C G+P P++TW +G+ L A R YKCIA N
Sbjct: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
Query: 1556 HGE----VETSCVVG-IQQKPVIT--ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK 1608
G+ +E S V +++ PVI + N + + H V E V G+PPP W K
Sbjct: 1152 TGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI----GMPPPVFYWKK 1207
Query: 1609 NGNKLENDKEYNITTKEKT--SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+ + +E ++ T + + I+ K+S + YT+ A N AG S L +Y
Sbjct: 1208 DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIY 1264
Score = 50.0 bits (114), Expect = 9e-05
Identities = 27/90 (30%), Positives = 46/90 (51%), Gaps = 4/90 (4%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F++K +++ V EG+ + L+C +V IP P + W +G+E+ +I + ++H
Sbjct: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS 325
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS 720
L I + G Y+ A N G S
Sbjct: 326 ----LTIAEAFEEDTGRYSCFASNIYGTDS 351
Score = 50.0 bits (114), Expect = 9e-05
Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 1595 VIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
++ GIPPP+V WY G +LEN + +I + I E + +Y+ ASN GT
Sbjct: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
Query: 1655 SVEVTLKVYD-KPSKPEGPVIMREISR 1680
S + + S EG E++R
Sbjct: 351 STSAEIYIEGVSSSDSEGDPNKEEMNR 377
Score = 49.6 bits (113), Expect = 1e-04
Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSI 789
+PP+ + L+S V +G V L VVG P P + W K ++ P G+ HS+
Sbjct: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
TI + + +D G Y+ A N G TSA I +E + ++E
Sbjct: 327 TIAEAFE-EDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSE 367
Score = 44.4 bits (100), Expect = 0.005
Identities = 38/151 (25%), Positives = 61/151 (40%), Gaps = 5/151 (3%)
Query: 774 PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPP 833
P+ A T+ + H++ + K+ + E + A + + + EEP +PP
Sbjct: 214 PIPA-DTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPL---GQPP 269
Query: 834 LFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVIT 893
F + + V E ++L V P P + WY + + S I G L I
Sbjct: 270 RFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIA 329
Query: 894 NVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
E D+G Y C ASN G S A + I+
Sbjct: 330 EAFEE-DTGRYSCFASNIYGTDSTSAEIYIE 359
Score = 43.6 bits (98), Expect = 0.008
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G+PPPE+ W NG + D + + +E + I L + + Y A+N G +
Sbjct: 1096 VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN 1155
Query: 1655 SVEVTLKVYDKPSKPEGPVIMREI 1678
S + L V K K + PVI+ ++
Sbjct: 1156 SFSLELSVVAKEVK-KAPVILEKL 1178
Score = 42.7 bits (96), Expect = 0.014
Identities = 28/109 (25%), Positives = 47/109 (43%), Gaps = 7/109 (6%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S ++ YY+ E Q P + L++ ++L CI G+P P+V WY +GK+L+
Sbjct: 254 SSPSSLYYE---EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE 310
Query: 1524 TAKATY----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+ + N Y C A N +G TS + I+
Sbjct: 311 NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
Score = 42.7 bits (96), Expect = 0.014
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 1463 DASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
D S+ + I K +P +K LK+ + TC G+P PKV W++DGK++
Sbjct: 926 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 985
Score = 41.5 bits (93), Expect = 0.032
Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 1106 PPEIITRLQNQKVNKGNKATFE-IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP +L++++V +G + + I + VRW+ +G E++ S I + G L
Sbjct: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
Query: 1165 IYDCDLDDAGEYSCEVGN 1182
I + +D G YSC N
Sbjct: 328 IAEAFEEDTGRYSCFASN 345
Score = 40.7 bits (91), Expect = 0.056
Identities = 32/99 (32%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQN-----FDG 885
P+F Q ++ E + RV P P + WYR +I SP I+Q +
Sbjct: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRISQKKPRSMAEP 494
Query: 886 ENI-ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E I LVI V +E SG + C ASN G S A++ +
Sbjct: 495 EEICTLVIAEVFAE-GSGCFTCTASNKYGTVSSIAQLHV 532
Score = 39.9 bits (89), Expect = 0.098
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNT 1650
T I GIP P+V W+K+G ++ E+ +E T + I+ YTI A+N
Sbjct: 965 TCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANP 1024
Query: 1651 AGTSSVEVTLKVYDKP 1666
G S L V P
Sbjct: 1025 QGRISCSGHLMVQSLP 1040
Score = 39.1 bits (87), Expect = 0.17
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 4/102 (3%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMHMY 691
P F+K + EG ++ ECR+ P P + W +G E PD IS M
Sbjct: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRISQKKPRSMAEP 494
Query: 692 CSVLKITNVKKFQEGT--YTVVAVNREGEASLPIVLKIKTGE 731
+ + + F EG+ +T A N+ G S L ++ E
Sbjct: 495 EEICTLVIAEVFAEGSGCFTCTASNKYGTVSSIAQLHVRGNE 536
Score = 38.3 bits (85), Expect = 0.30
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
I +P K L+N++ + + C G P PKV WYR+G
Sbjct: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
Score = 37.5 bits (83), Expect = 0.52
Identities = 31/113 (27%), Positives = 50/113 (44%), Gaps = 11/113 (9%)
Query: 1561 TSCVVGIQQKPVITISN-EDIKQKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDK 1617
T+ + G+ KP+I + Q + LV ++G P P+V WY+ G +E+
Sbjct: 420 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
Query: 1618 EYNITTK--------EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ I+ K E+ + I E+ S +T ASN GT S L V
Sbjct: 480 DFRISQKKPRSMAEPEEICTLVIAEVFAEGSGCFTCTASNKYGTVSSIAQLHV 532
Score = 36.3 bits (80), Expect = 1.2
Identities = 45/191 (23%), Positives = 77/191 (40%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D E + L+ +++ ++ W +G+ + P + + + L
Sbjct: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
Query: 1076 IRNTSVHDEGEYSCILRDE----SCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y CI ++ S + E++V V+ P I+ +LQN V +G+ E
Sbjct: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQK-LKIYDCDLDDAGEYSC----EV 1180
+ + W KD I + I + D L I DAG Y+ E
Sbjct: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
Query: 1181 GNSKCTAILTV 1191
G CTA L +
Sbjct: 1253 GIVSCTARLDI 1263
Score = 33.9 bits (74), Expect = 6.4
Identities = 24/81 (29%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSN-HIQLTIDGKKQ- 1161
+ P RL++ +V +G+ TF ++ V WFKDG +I N H ++ +G
Sbjct: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
Query: 1162 KLKIYDCDLDDAGEYSCEVGN 1182
L I DD G Y+ N
Sbjct: 1003 SLHIESTTSDDDGNYTIMAAN 1023
>AL512429-2|CAH73748.1| 1320|Homo sapiens sarcomeric protein
myopalladin, 145 kDa (MYOP) protein.
Length = 1320
Score = 147 bits (355), Expect = 6e-34
Identities = 98/375 (26%), Positives = 179/375 (47%), Gaps = 17/375 (4%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
Q LM+E + + + ++E D++ E PT + +APIF ++L+ +GS V F C
Sbjct: 910 QRLMNEIEF-RLERTPVDESDDEIQHDEIPTGK--CIAPIFDKRLKHFRVTEGSPVTFTC 966
Query: 532 QVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
++ G P P++ WF+ I K ++ +M + D +L I +D G +T +A N G
Sbjct: 967 KIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
Query: 591 FASSTTELIVEA-PLSDHGSEMTVXXXXXXXXXXXXADILEG--IPPTFSKKPKAQYVDE 647
S + L+V++ P+ + + L+ P F + P E
Sbjct: 1027 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHE 1086
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI-ESDMHMYCSVLKITNVKKFQEG 706
G L+C++ +P P++ WL G+ ++PD + + + E+ +H L I + + G
Sbjct: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS----LLIDPLTQRDAG 1142
Query: 707 TYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
TY +A N+ G+ S + L + E K+ P ++E L++ V +G V L +V+G P P
Sbjct: 1143 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 1202
Query: 766 ITWCKNNKPV----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
W K+N+ + + + D ++ +++P K D G YTL A+N GI +A +
Sbjct: 1203 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLD 1262
Query: 822 VEEPTEENAEPPLFI 836
+ PP+ +
Sbjct: 1263 IYAQWHHQIPPPMSV 1277
Score = 96.3 bits (229), Expect = 1e-18
Identities = 91/329 (27%), Positives = 141/329 (42%), Gaps = 45/329 (13%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHM 690
I P F K+ K V EGS + C++V IP P + W G++I +E+ + E D
Sbjct: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT- 1001
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS---------LPIVLKIKTG----------- 730
CS L I + +G YT++A N +G S LPI ++ +
Sbjct: 1002 -CS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
Query: 731 --EKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK 781
+KEP P ++ M+ +G L +V G P P +TW N +PV LP
Sbjct: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV--LPDA 1117
Query: 782 S------DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLF 835
S + HS+ ++ P +D G Y A N G + S + + +E + P+
Sbjct: 1118 SHKMLVRETGVHSL-LIDPLTQRDAGTYKCIATNKTG--QNSFSLELSVVAKEVKKAPVI 1174
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII-SPSETITQNFDGENIELVITN 894
+ + Q V E ++L RV P P W ++NE I E I+ + D ++
Sbjct: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
Query: 895 VDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ D+G Y A N AG S AR+ I
Sbjct: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
Score = 84.2 bits (199), Expect = 5e-15
Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 9/142 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY-------D 561
AP+F + L+ +G V FEC+V+G P P++ W+R+ +I+ S DF++ +
Sbjct: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXX 619
+ + TLVI EVF ED+G FTC A N G SS +L V LS++GS +
Sbjct: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL 553
Query: 620 XXXXXXADILEGIPPTFSKKPK 641
PP+ + PK
Sbjct: 554 AAIEPQPSPPHSEPPSVEQPPK 575
Score = 72.5 bits (170), Expect = 1e-11
Identities = 37/107 (34%), Positives = 57/107 (53%), Gaps = 2/107 (1%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
E P F +KLR + P+G+ VQ +C V G P PQ+ W+ + ++ S D +
Sbjct: 263 EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI-VQAG 321
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSE 610
N+ +L I E F ED G ++C A N G S++ E+ +E +S SE
Sbjct: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG-VSSSDSE 367
Score = 68.5 bits (160), Expect = 2e-10
Identities = 58/259 (22%), Positives = 108/259 (41%), Gaps = 33/259 (12%)
Query: 726 KIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTK 781
+I TG+ P + LK V +G V + ++VG P P + W K+ K + +
Sbjct: 936 EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMR 995
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE------------------ 823
+GD ++ D+G YT+ A N +G S + V+
Sbjct: 996 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 1055
Query: 824 --------EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
EP +E P F+ ++ E +L +V+ P P +TW N + + P
Sbjct: 1056 SRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1115
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI---DVEKVTFVK 932
+ + ++ + ++ D+G YKC+A+N G++S +++ +V+K +
Sbjct: 1116 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL 1175
Query: 933 HLQKSYETEEGKTVILECQ 951
++ EG V LEC+
Sbjct: 1176 EKLQNCGVPEGHPVRLECR 1194
Score = 50.8 bits (116), Expect = 5e-05
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 18/177 (10%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKK-LKTAKATYENRXXXXXXXX----XXXXXXXYKCIAFND 1555
L C G+P P++TW +G+ L A R YKCIA N
Sbjct: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
Query: 1556 HGE----VETSCVVG-IQQKPVIT--ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK 1608
G+ +E S V +++ PVI + N + + H V E V G+PPP W K
Sbjct: 1152 TGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI----GMPPPVFYWKK 1207
Query: 1609 NGNKLENDKEYNITTKEKT--SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+ + +E ++ T + + I+ K+S + YT+ A N AG S L +Y
Sbjct: 1208 DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIY 1264
Score = 50.0 bits (114), Expect = 9e-05
Identities = 27/90 (30%), Positives = 46/90 (51%), Gaps = 4/90 (4%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F++K +++ V EG+ + L+C +V IP P + W +G+E+ +I + ++H
Sbjct: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS 325
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS 720
L I + G Y+ A N G S
Sbjct: 326 ----LTIAEAFEEDTGRYSCFASNIYGTDS 351
Score = 50.0 bits (114), Expect = 9e-05
Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 1595 VIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
++ GIPPP+V WY G +LEN + +I + I E + +Y+ ASN GT
Sbjct: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
Query: 1655 SVEVTLKVYD-KPSKPEGPVIMREISR 1680
S + + S EG E++R
Sbjct: 351 STSAEIYIEGVSSSDSEGDPNKEEMNR 377
Score = 49.6 bits (113), Expect = 1e-04
Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSI 789
+PP+ + L+S V +G V L VVG P P + W K ++ P G+ HS+
Sbjct: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
TI + + +D G Y+ A N G TSA I +E + ++E
Sbjct: 327 TIAEAFE-EDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSE 367
Score = 44.4 bits (100), Expect = 0.005
Identities = 38/151 (25%), Positives = 61/151 (40%), Gaps = 5/151 (3%)
Query: 774 PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPP 833
P+ A T+ + H++ + K+ + E + A + + + EEP +PP
Sbjct: 214 PIPA-DTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPL---GQPP 269
Query: 834 LFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVIT 893
F + + V E ++L V P P + WY + + S I G L I
Sbjct: 270 RFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIA 329
Query: 894 NVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
E D+G Y C ASN G S A + I+
Sbjct: 330 EAFEE-DTGRYSCFASNIYGTDSTSAEIYIE 359
Score = 43.6 bits (98), Expect = 0.008
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G+PPPE+ W NG + D + + +E + I L + + Y A+N G +
Sbjct: 1096 VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN 1155
Query: 1655 SVEVTLKVYDKPSKPEGPVIMREI 1678
S + L V K K + PVI+ ++
Sbjct: 1156 SFSLELSVVAKEVK-KAPVILEKL 1178
Score = 42.7 bits (96), Expect = 0.014
Identities = 28/109 (25%), Positives = 47/109 (43%), Gaps = 7/109 (6%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S ++ YY+ E Q P + L++ ++L CI G+P P+V WY +GK+L+
Sbjct: 254 SSPSSLYYE---EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE 310
Query: 1524 TAKATY----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+ + N Y C A N +G TS + I+
Sbjct: 311 NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/99 (33%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQN-----FDG 885
P+F Q ++ E + RV P P + WYR +I SP I Q +
Sbjct: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
Query: 886 ENI-ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E I LVI V +E DSG + C ASN G S A++ +
Sbjct: 495 EEICTLVIAEVFAE-DSGCFTCTASNKYGTVSSIAQLHV 532
Score = 42.7 bits (96), Expect = 0.014
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 1463 DASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
D S+ + I K +P +K LK+ + TC G+P PKV W++DGK++
Sbjct: 926 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 985
Score = 41.5 bits (93), Expect = 0.032
Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 1106 PPEIITRLQNQKVNKGNKATFE-IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP +L++++V +G + + I + VRW+ +G E++ S I + G L
Sbjct: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
Query: 1165 IYDCDLDDAGEYSCEVGN 1182
I + +D G YSC N
Sbjct: 328 IAEAFEEDTGRYSCFASN 345
Score = 39.9 bits (89), Expect = 0.098
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNT 1650
T I GIP P+V W+K+G ++ E+ +E T + I+ YTI A+N
Sbjct: 965 TCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANP 1024
Query: 1651 AGTSSVEVTLKVYDKP 1666
G S L V P
Sbjct: 1025 QGRISCSGHLMVQSLP 1040
Score = 38.3 bits (85), Expect = 0.30
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
I +P K L+N++ + + C G P PKV WYR+G
Sbjct: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
Score = 37.1 bits (82), Expect = 0.69
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 11/113 (9%)
Query: 1561 TSCVVGIQQKPVITISN-EDIKQKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDK 1617
T+ + G+ KP+I + Q + LV ++G P P+V WY+ G +E+
Sbjct: 420 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
Query: 1618 EYNITTK--------EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ I K E+ + I E+ S +T ASN GT S L V
Sbjct: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
Score = 36.3 bits (80), Expect = 1.2
Identities = 45/191 (23%), Positives = 77/191 (40%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D E + L+ +++ ++ W +G+ + P + + + L
Sbjct: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
Query: 1076 IRNTSVHDEGEYSCILRDE----SCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y CI ++ S + E++V V+ P I+ +LQN V +G+ E
Sbjct: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQK-LKIYDCDLDDAGEYSC----EV 1180
+ + W KD I + I + D L I DAG Y+ E
Sbjct: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
Query: 1181 GNSKCTAILTV 1191
G CTA L +
Sbjct: 1253 GIVSCTARLDI 1263
Score = 35.9 bits (79), Expect = 1.6
Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 4/102 (3%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM--- 690
P F+K + EG ++ ECR+ P P + W +G I + + + M
Sbjct: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
Query: 691 -YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE 731
L I V G +T A N+ G S L ++ E
Sbjct: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
Score = 33.9 bits (74), Expect = 6.4
Identities = 24/81 (29%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSN-HIQLTIDGKKQ- 1161
+ P RL++ +V +G+ TF ++ V WFKDG +I N H ++ +G
Sbjct: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
Query: 1162 KLKIYDCDLDDAGEYSCEVGN 1182
L I DD G Y+ N
Sbjct: 1003 SLHIESTTSDDDGNYTIMAAN 1023
>AL512429-1|CAH73747.1| 1045|Homo sapiens sarcomeric protein
myopalladin, 145 kDa (MYOP) protein.
Length = 1045
Score = 147 bits (355), Expect = 6e-34
Identities = 98/375 (26%), Positives = 179/375 (47%), Gaps = 17/375 (4%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
Q LM+E + + + ++E D++ E PT + +APIF ++L+ +GS V F C
Sbjct: 635 QRLMNEIEF-RLERTPVDESDDEIQHDEIPTGK--CIAPIFDKRLKHFRVTEGSPVTFTC 691
Query: 532 QVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
++ G P P++ WF+ I K ++ +M + D +L I +D G +T +A N G
Sbjct: 692 KIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 751
Query: 591 FASSTTELIVEA-PLSDHGSEMTVXXXXXXXXXXXXADILEG--IPPTFSKKPKAQYVDE 647
S + L+V++ P+ + + L+ P F + P E
Sbjct: 752 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHE 811
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI-ESDMHMYCSVLKITNVKKFQEG 706
G L+C++ +P P++ WL G+ ++PD + + + E+ +H L I + + G
Sbjct: 812 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS----LLIDPLTQRDAG 867
Query: 707 TYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
TY +A N+ G+ S + L + E K+ P ++E L++ V +G V L +V+G P P
Sbjct: 868 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 927
Query: 766 ITWCKNNKPV----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
W K+N+ + + + D ++ +++P K D G YTL A+N GI +A +
Sbjct: 928 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLD 987
Query: 822 VEEPTEENAEPPLFI 836
+ PP+ +
Sbjct: 988 IYAQWHHQIPPPMSV 1002
Score = 96.3 bits (229), Expect = 1e-18
Identities = 91/329 (27%), Positives = 141/329 (42%), Gaps = 45/329 (13%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHM 690
I P F K+ K V EGS + C++V IP P + W G++I +E+ + E D
Sbjct: 668 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT- 726
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS---------LPIVLKIKTG----------- 730
CS L I + +G YT++A N +G S LPI ++ +
Sbjct: 727 -CS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 784
Query: 731 --EKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK 781
+KEP P ++ M+ +G L +V G P P +TW N +PV LP
Sbjct: 785 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV--LPDA 842
Query: 782 S------DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLF 835
S + HS+ ++ P +D G Y A N G + S + + +E + P+
Sbjct: 843 SHKMLVRETGVHSL-LIDPLTQRDAGTYKCIATNKTG--QNSFSLELSVVAKEVKKAPVI 899
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII-SPSETITQNFDGENIELVITN 894
+ + Q V E ++L RV P P W ++NE I E I+ + D ++
Sbjct: 900 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 959
Query: 895 VDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ D+G Y A N AG S AR+ I
Sbjct: 960 PAKKSDAGWYTLSAKNEAGIVSCTARLDI 988
Score = 84.2 bits (199), Expect = 5e-15
Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 9/142 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY-------D 561
AP+F + L+ +G V FEC+V+G P P++ W+R+ +I+ S DF++ +
Sbjct: 159 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 218
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXX 619
+ + TLVI EVF ED+G FTC A N G SS +L V LS++GS +
Sbjct: 219 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL 278
Query: 620 XXXXXXADILEGIPPTFSKKPK 641
PP+ + PK
Sbjct: 279 AAIEPQPSPPHSEPPSVEQPPK 300
Score = 68.5 bits (160), Expect = 2e-10
Identities = 58/259 (22%), Positives = 108/259 (41%), Gaps = 33/259 (12%)
Query: 726 KIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTK 781
+I TG+ P + LK V +G V + ++VG P P + W K+ K + +
Sbjct: 661 EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMR 720
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE------------------ 823
+GD ++ D+G YT+ A N +G S + V+
Sbjct: 721 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 780
Query: 824 --------EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
EP +E P F+ ++ E +L +V+ P P +TW N + + P
Sbjct: 781 SRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 840
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI---DVEKVTFVK 932
+ + ++ + ++ D+G YKC+A+N G++S +++ +V+K +
Sbjct: 841 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL 900
Query: 933 HLQKSYETEEGKTVILECQ 951
++ EG V LEC+
Sbjct: 901 EKLQNCGVPEGHPVRLECR 919
Score = 50.8 bits (116), Expect = 5e-05
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 18/177 (10%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKK-LKTAKATYENRXXXXXXXX----XXXXXXXYKCIAFND 1555
L C G+P P++TW +G+ L A R YKCIA N
Sbjct: 817 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 876
Query: 1556 HGE----VETSCVVG-IQQKPVIT--ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK 1608
G+ +E S V +++ PVI + N + + H V E V G+PPP W K
Sbjct: 877 TGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI----GMPPPVFYWKK 932
Query: 1609 NGNKLENDKEYNITTKEKT--SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+ + +E ++ T + + I+ K+S + YT+ A N AG S L +Y
Sbjct: 933 DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIY 989
Score = 43.6 bits (98), Expect = 0.008
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G+PPPE+ W NG + D + + +E + I L + + Y A+N G +
Sbjct: 821 VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN 880
Query: 1655 SVEVTLKVYDKPSKPEGPVIMREI 1678
S + L V K K + PVI+ ++
Sbjct: 881 SFSLELSVVAKEVK-KAPVILEKL 903
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/99 (33%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQN-----FDG 885
P+F Q ++ E + RV P P + WYR +I SP I Q +
Sbjct: 160 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 219
Query: 886 ENI-ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E I LVI V +E DSG + C ASN G S A++ +
Sbjct: 220 EEICTLVIAEVFAE-DSGCFTCTASNKYGTVSSIAQLHV 257
Score = 42.7 bits (96), Expect = 0.014
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 1463 DASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
D S+ + I K +P +K LK+ + TC G+P PKV W++DGK++
Sbjct: 651 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 710
Score = 39.9 bits (89), Expect = 0.098
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNT 1650
T I GIP P+V W+K+G ++ E+ +E T + I+ YTI A+N
Sbjct: 690 TCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANP 749
Query: 1651 AGTSSVEVTLKVYDKP 1666
G S L V P
Sbjct: 750 QGRISCSGHLMVQSLP 765
Score = 38.3 bits (85), Expect = 0.30
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
I +P K L+N++ + + C G P PKV WYR+G
Sbjct: 157 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG 197
Score = 37.9 bits (84), Expect = 0.39
Identities = 21/68 (30%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 543 WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
W+ + ++ S D + N+ +L I E F ED G ++C A N G S++ E+ +E
Sbjct: 27 WYCEGKELENSPDIHIV-QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 85
Query: 603 PLSDHGSE 610
+S SE
Sbjct: 86 -VSSSDSE 92
Score = 37.1 bits (82), Expect = 0.69
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 11/113 (9%)
Query: 1561 TSCVVGIQQKPVITISN-EDIKQKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDK 1617
T+ + G+ KP+I + Q + LV ++G P P+V WY+ G +E+
Sbjct: 145 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 204
Query: 1618 EYNITTK--------EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ I K E+ + I E+ S +T ASN GT S L V
Sbjct: 205 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 257
Score = 36.3 bits (80), Expect = 1.2
Identities = 45/191 (23%), Positives = 77/191 (40%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D E + L+ +++ ++ W +G+ + P + + + L
Sbjct: 798 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 857
Query: 1076 IRNTSVHDEGEYSCILRDE----SCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y CI ++ S + E++V V+ P I+ +LQN V +G+ E
Sbjct: 858 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 917
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQK-LKIYDCDLDDAGEYSC----EV 1180
+ + W KD I + I + D L I DAG Y+ E
Sbjct: 918 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 977
Query: 1181 GNSKCTAILTV 1191
G CTA L +
Sbjct: 978 GIVSCTARLDI 988
Score = 35.9 bits (79), Expect = 1.6
Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 4/102 (3%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM--- 690
P F+K + EG ++ ECR+ P P + W +G I + + + M
Sbjct: 160 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 219
Query: 691 -YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE 731
L I V G +T A N+ G S L ++ E
Sbjct: 220 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 261
Score = 35.1 bits (77), Expect = 2.8
Identities = 21/77 (27%), Positives = 33/77 (42%), Gaps = 1/77 (1%)
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD 1664
+WY G +LEN + +I + I E + +Y+ ASN GT S + +
Sbjct: 26 MWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 85
Query: 1665 -KPSKPEGPVIMREISR 1680
S EG E++R
Sbjct: 86 VSSSDSEGDPNKEEMNR 102
Score = 33.9 bits (74), Expect = 6.4
Identities = 24/81 (29%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSN-HIQLTIDGKKQ- 1161
+ P RL++ +V +G+ TF ++ V WFKDG +I N H ++ +G
Sbjct: 668 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 727
Query: 1162 KLKIYDCDLDDAGEYSCEVGN 1182
L I DD G Y+ N
Sbjct: 728 SLHIESTTSDDDGNYTIMAAN 748
>AF328296-1|AAK50625.1| 1320|Homo sapiens myopalladin protein.
Length = 1320
Score = 147 bits (355), Expect = 6e-34
Identities = 98/375 (26%), Positives = 179/375 (47%), Gaps = 17/375 (4%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
Q LM+E + + + ++E D++ E PT + +APIF ++L+ +GS V F C
Sbjct: 910 QRLMNEIEF-RLERTPVDESDDEIQHDEIPTGK--CIAPIFDKRLKHFRVTEGSPVTFTC 966
Query: 532 QVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
++ G P P++ WF+ I K ++ +M + D +L I +D G +T +A N G
Sbjct: 967 KIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
Query: 591 FASSTTELIVEA-PLSDHGSEMTVXXXXXXXXXXXXADILEG--IPPTFSKKPKAQYVDE 647
S + L+V++ P+ + + L+ P F + P E
Sbjct: 1027 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHE 1086
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI-ESDMHMYCSVLKITNVKKFQEG 706
G L+C++ +P P++ WL G+ ++PD + + + E+ +H L I + + G
Sbjct: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS----LLIDPLTQRDAG 1142
Query: 707 TYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
TY +A N+ G+ S + L + E K+ P ++E L++ V +G V L +V+G P P
Sbjct: 1143 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 1202
Query: 766 ITWCKNNKPV----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
W K+N+ + + + D ++ +++P K D G YTL A+N GI +A +
Sbjct: 1203 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLD 1262
Query: 822 VEEPTEENAEPPLFI 836
+ PP+ +
Sbjct: 1263 IYAQWHHQIPPPMSV 1277
Score = 96.3 bits (229), Expect = 1e-18
Identities = 91/329 (27%), Positives = 141/329 (42%), Gaps = 45/329 (13%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHM 690
I P F K+ K V EGS + C++V IP P + W G++I +E+ + E D
Sbjct: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT- 1001
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS---------LPIVLKIKTG----------- 730
CS L I + +G YT++A N +G S LPI ++ +
Sbjct: 1002 -CS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
Query: 731 --EKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK 781
+KEP P ++ M+ +G L +V G P P +TW N +PV LP
Sbjct: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV--LPDA 1117
Query: 782 S------DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLF 835
S + HS+ ++ P +D G Y A N G + S + + +E + P+
Sbjct: 1118 SHKMLVRETGVHSL-LIDPLTQRDAGTYKCIATNKTG--QNSFSLELSVVAKEVKKAPVI 1174
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII-SPSETITQNFDGENIELVITN 894
+ + Q V E ++L RV P P W ++NE I E I+ + D ++
Sbjct: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
Query: 895 VDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ D+G Y A N AG S AR+ I
Sbjct: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
Score = 84.2 bits (199), Expect = 5e-15
Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 9/142 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY-------D 561
AP+F + L+ +G V FEC+V+G P P++ W+R+ +I+ S DF++ +
Sbjct: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXX 619
+ + TLVI EVF ED+G FTC A N G SS +L V LS++GS +
Sbjct: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL 553
Query: 620 XXXXXXADILEGIPPTFSKKPK 641
PP+ + PK
Sbjct: 554 AAIEPQPSPPHSEPPSVEQPPK 575
Score = 72.5 bits (170), Expect = 1e-11
Identities = 37/107 (34%), Positives = 57/107 (53%), Gaps = 2/107 (1%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
E P F +KLR + P+G+ VQ +C V G P PQ+ W+ + ++ S D +
Sbjct: 263 EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI-VQAG 321
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSE 610
N+ +L I E F ED G ++C A N G S++ E+ +E +S SE
Sbjct: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG-VSSSDSE 367
Score = 68.5 bits (160), Expect = 2e-10
Identities = 58/259 (22%), Positives = 108/259 (41%), Gaps = 33/259 (12%)
Query: 726 KIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTK 781
+I TG+ P + LK V +G V + ++VG P P + W K+ K + +
Sbjct: 936 EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMR 995
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE------------------ 823
+GD ++ D+G YT+ A N +G S + V+
Sbjct: 996 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 1055
Query: 824 --------EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
EP +E P F+ ++ E +L +V+ P P +TW N + + P
Sbjct: 1056 SRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1115
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI---DVEKVTFVK 932
+ + ++ + ++ D+G YKC+A+N G++S +++ +V+K +
Sbjct: 1116 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL 1175
Query: 933 HLQKSYETEEGKTVILECQ 951
++ EG V LEC+
Sbjct: 1176 EKLQNCGVPEGHPVRLECR 1194
Score = 50.8 bits (116), Expect = 5e-05
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 18/177 (10%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKK-LKTAKATYENRXXXXXXXX----XXXXXXXYKCIAFND 1555
L C G+P P++TW +G+ L A R YKCIA N
Sbjct: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
Query: 1556 HGE----VETSCVVG-IQQKPVIT--ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK 1608
G+ +E S V +++ PVI + N + + H V E V G+PPP W K
Sbjct: 1152 TGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI----GMPPPVFYWKK 1207
Query: 1609 NGNKLENDKEYNITTKEKT--SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+ + +E ++ T + + I+ K+S + YT+ A N AG S L +Y
Sbjct: 1208 DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIY 1264
Score = 50.0 bits (114), Expect = 9e-05
Identities = 27/90 (30%), Positives = 46/90 (51%), Gaps = 4/90 (4%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F++K +++ V EG+ + L+C +V IP P + W +G+E+ +I + ++H
Sbjct: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS 325
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS 720
L I + G Y+ A N G S
Sbjct: 326 ----LTIAEAFEEDTGRYSCFASNIYGTDS 351
Score = 50.0 bits (114), Expect = 9e-05
Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 1595 VIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
++ GIPPP+V WY G +LEN + +I + I E + +Y+ ASN GT
Sbjct: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
Query: 1655 SVEVTLKVYD-KPSKPEGPVIMREISR 1680
S + + S EG E++R
Sbjct: 351 STSAEIYIEGVSSSDSEGDPNKEEMNR 377
Score = 49.6 bits (113), Expect = 1e-04
Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSI 789
+PP+ + L+S V +G V L VVG P P + W K ++ P G+ HS+
Sbjct: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
TI + + +D G Y+ A N G TSA I +E + ++E
Sbjct: 327 TIAEAFE-EDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSE 367
Score = 44.4 bits (100), Expect = 0.005
Identities = 38/151 (25%), Positives = 61/151 (40%), Gaps = 5/151 (3%)
Query: 774 PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPP 833
P+ A T+ + H++ + K+ + E + A + + + EEP +PP
Sbjct: 214 PIPA-DTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPL---GQPP 269
Query: 834 LFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVIT 893
F + + V E ++L V P P + WY + + S I G L I
Sbjct: 270 RFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIA 329
Query: 894 NVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
E D+G Y C ASN G S A + I+
Sbjct: 330 EAFEE-DTGRYSCFASNIYGTDSTSAEIYIE 359
Score = 43.6 bits (98), Expect = 0.008
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G+PPPE+ W NG + D + + +E + I L + + Y A+N G +
Sbjct: 1096 VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN 1155
Query: 1655 SVEVTLKVYDKPSKPEGPVIMREI 1678
S + L V K K + PVI+ ++
Sbjct: 1156 SFSLELSVVAKEVK-KAPVILEKL 1178
Score = 42.7 bits (96), Expect = 0.014
Identities = 28/109 (25%), Positives = 47/109 (43%), Gaps = 7/109 (6%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S ++ YY+ E Q P + L++ ++L CI G+P P+V WY +GK+L+
Sbjct: 254 SSPSSLYYE---EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE 310
Query: 1524 TAKATY----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+ + N Y C A N +G TS + I+
Sbjct: 311 NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/99 (33%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQN-----FDG 885
P+F Q ++ E + RV P P + WYR +I SP I Q +
Sbjct: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
Query: 886 ENI-ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E I LVI V +E DSG + C ASN G S A++ +
Sbjct: 495 EEICTLVIAEVFAE-DSGCFTCTASNKYGTVSSIAQLHV 532
Score = 42.7 bits (96), Expect = 0.014
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 1463 DASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
D S+ + I K +P +K LK+ + TC G+P PKV W++DGK++
Sbjct: 926 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 985
Score = 41.5 bits (93), Expect = 0.032
Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 1106 PPEIITRLQNQKVNKGNKATFE-IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP +L++++V +G + + I + VRW+ +G E++ S I + G L
Sbjct: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
Query: 1165 IYDCDLDDAGEYSCEVGN 1182
I + +D G YSC N
Sbjct: 328 IAEAFEEDTGRYSCFASN 345
Score = 39.9 bits (89), Expect = 0.098
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 2/76 (2%)
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNT 1650
T I GIP P+V W+K+G ++ E+ +E T + I+ YTI A+N
Sbjct: 965 TCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANP 1024
Query: 1651 AGTSSVEVTLKVYDKP 1666
G S L V P
Sbjct: 1025 QGRISCSGHLMVQSLP 1040
Score = 38.3 bits (85), Expect = 0.30
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
I +P K L+N++ + + C G P PKV WYR+G
Sbjct: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
Score = 37.1 bits (82), Expect = 0.69
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 11/113 (9%)
Query: 1561 TSCVVGIQQKPVITISN-EDIKQKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDK 1617
T+ + G+ KP+I + Q + LV ++G P P+V WY+ G +E+
Sbjct: 420 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
Query: 1618 EYNITTK--------EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ I K E+ + I E+ S +T ASN GT S L V
Sbjct: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
Score = 36.3 bits (80), Expect = 1.2
Identities = 45/191 (23%), Positives = 77/191 (40%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D E + L+ +++ ++ W +G+ + P + + + L
Sbjct: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
Query: 1076 IRNTSVHDEGEYSCILRDE----SCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y CI ++ S + E++V V+ P I+ +LQN V +G+ E
Sbjct: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQK-LKIYDCDLDDAGEYSC----EV 1180
+ + W KD I + I + D L I DAG Y+ E
Sbjct: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
Query: 1181 GNSKCTAILTV 1191
G CTA L +
Sbjct: 1253 GIVSCTARLDI 1263
Score = 35.9 bits (79), Expect = 1.6
Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 4/102 (3%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM--- 690
P F+K + EG ++ ECR+ P P + W +G I + + + M
Sbjct: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
Query: 691 -YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE 731
L I V G +T A N+ G S L ++ E
Sbjct: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
Score = 33.9 bits (74), Expect = 6.4
Identities = 24/81 (29%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSN-HIQLTIDGKKQ- 1161
+ P RL++ +V +G+ TF ++ V WFKDG +I N H ++ +G
Sbjct: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
Query: 1162 KLKIYDCDLDDAGEYSCEVGN 1182
L I DD G Y+ N
Sbjct: 1003 SLHIESTTSDDDGNYTIMAAN 1023
>AL834247-1|CAD38923.2| 1391|Homo sapiens hypothetical protein
protein.
Length = 1391
Score = 145 bits (351), Expect = 2e-33
Identities = 98/375 (26%), Positives = 178/375 (47%), Gaps = 17/375 (4%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
Q LM+E + + + ++E D++ E PT + +APIF ++L+ +GS V F C
Sbjct: 981 QRLMNEIEF-RLERTPVDESDDEIQHDEIPTGK--CIAPIFDKRLKHFRVTEGSPVTFTC 1037
Query: 532 QVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
++ G P P++ WF+ I K ++ +M + D +L I +D G +T +A N G
Sbjct: 1038 KIVGIPVPKVYWFKDGKQISKRNERCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1097
Query: 591 FASSTTELIVEA-PLSDHGSEMTVXXXXXXXXXXXXADILEG--IPPTFSKKPKAQYVDE 647
S + L+V++ P+ + + L+ P F + P E
Sbjct: 1098 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHE 1157
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI-ESDMHMYCSVLKITNVKKFQEG 706
G L+C++ +P P++ WL G+ ++PD + + E+ +H L I + + G
Sbjct: 1158 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDAPHKMLVRETGVHS----LLIDPLTQRDAG 1213
Query: 707 TYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
TY +A N+ G+ S + L + E K+ P ++E L++ V +G V L +V+G P P
Sbjct: 1214 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 1273
Query: 766 ITWCKNNKPV----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
W K+N+ + + + D ++ +++P K D G YTL A+N GI +A +
Sbjct: 1274 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLD 1333
Query: 822 VEEPTEENAEPPLFI 836
+ PP+ +
Sbjct: 1334 IYAQWHHQIPPPMSV 1348
Score = 95.9 bits (228), Expect = 1e-18
Identities = 90/327 (27%), Positives = 139/327 (42%), Gaps = 41/327 (12%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP-DENISVAIESDMHM 690
I P F K+ K V EGS + C++V IP P + W G++I +E + E D
Sbjct: 1014 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNERCKMRREGDGT- 1072
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS---------LPIVLKIKTG----------- 730
CS L I + +G YT++A N +G S LPI ++ +
Sbjct: 1073 -CS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1130
Query: 731 --EKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA-LPT 780
+KEP P ++ M+ +G L +V G P P +TW N +PV P
Sbjct: 1131 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDAPH 1190
Query: 781 KS---DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN 837
K + HS+ ++ P +D G Y A N G + S + + +E + P+ +
Sbjct: 1191 KMLVRETGVHSL-LIDPLTQRDAGTYKCIATNKTG--QNSFSLELSVVAKEVKKAPVILE 1247
Query: 838 RFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII-SPSETITQNFDGENIELVITNVD 896
+ Q V E ++L RV P P W ++NE I E I+ + D ++
Sbjct: 1248 KLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPA 1307
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTI 923
+ D+G Y A N AG S AR+ I
Sbjct: 1308 KKSDAGWYTLSAKNEAGIVSCTARLDI 1334
Score = 84.2 bits (199), Expect = 5e-15
Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 9/142 (6%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY-------D 561
AP+F + L+ +G V FEC+V+G P P++ W+R+ +I+ S DF++ +
Sbjct: 505 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 564
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA--PLSDHGSEMTVXXXXXX 619
+ + TLVI EVF ED+G FTC A N G SS +L V LS++GS +
Sbjct: 565 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL 624
Query: 620 XXXXXXADILEGIPPTFSKKPK 641
PP+ + PK
Sbjct: 625 AAIEPQPSPPHSEPPSVEQPPK 646
Score = 72.5 bits (170), Expect = 1e-11
Identities = 37/107 (34%), Positives = 57/107 (53%), Gaps = 2/107 (1%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
E P F +KLR + P+G+ VQ +C V G P PQ+ W+ + ++ S D +
Sbjct: 334 EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI-VQAG 392
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSE 610
N+ +L I E F ED G ++C A N G S++ E+ +E +S SE
Sbjct: 393 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG-VSSSDSE 438
Score = 68.1 bits (159), Expect = 3e-10
Identities = 58/259 (22%), Positives = 108/259 (41%), Gaps = 33/259 (12%)
Query: 726 KIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV----KALPTK 781
+I TG+ P + LK V +G V + ++VG P P + W K+ K + + +
Sbjct: 1007 EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNERCKMR 1066
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE------------------ 823
+GD ++ D+G YT+ A N +G S + V+
Sbjct: 1067 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 1126
Query: 824 --------EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
EP +E P F+ ++ E +L +V+ P P +TW N + + P
Sbjct: 1127 SRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1186
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI---DVEKVTFVK 932
+ ++ + ++ D+G YKC+A+N G++S +++ +V+K +
Sbjct: 1187 DAPHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL 1246
Query: 933 HLQKSYETEEGKTVILECQ 951
++ EG V LEC+
Sbjct: 1247 EKLQNCGVPEGHPVRLECR 1265
Score = 50.4 bits (115), Expect = 7e-05
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 18/177 (10%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKK-LKTAKATYENRXXXXXXXX----XXXXXXXYKCIAFND 1555
L C G+P P++TW +G+ L A R YKCIA N
Sbjct: 1163 LDCKVSGLPPPELTWLLNGQPVLPDAPHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1222
Query: 1556 HGE----VETSCVVG-IQQKPVIT--ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK 1608
G+ +E S V +++ PVI + N + + H V E V G+PPP W K
Sbjct: 1223 TGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI----GMPPPVFYWKK 1278
Query: 1609 NGNKLENDKEYNITTKEKT--SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+ + +E ++ T + + I+ K+S + YT+ A N AG S L +Y
Sbjct: 1279 DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIY 1335
Score = 50.0 bits (114), Expect = 9e-05
Identities = 27/90 (30%), Positives = 46/90 (51%), Gaps = 4/90 (4%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F++K +++ V EG+ + L+C +V IP P + W +G+E+ +I + ++H
Sbjct: 337 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS 396
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEAS 720
L I + G Y+ A N G S
Sbjct: 397 ----LTIAEAFEEDTGRYSCFASNIYGTDS 422
Score = 50.0 bits (114), Expect = 9e-05
Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 1595 VIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
++ GIPPP+V WY G +LEN + +I + I E + +Y+ ASN GT
Sbjct: 362 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 421
Query: 1655 SVEVTLKVYD-KPSKPEGPVIMREISR 1680
S + + S EG E++R
Sbjct: 422 STSAEIYIEGVSSSDSEGDPNKEEMNR 448
Score = 49.6 bits (113), Expect = 1e-04
Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSI 789
+PP+ + L+S V +G V L VVG P P + W K ++ P G+ HS+
Sbjct: 338 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 397
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
TI + + +D G Y+ A N G TSA I +E + ++E
Sbjct: 398 TIAEAFE-EDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSE 438
Score = 44.4 bits (100), Expect = 0.005
Identities = 38/151 (25%), Positives = 61/151 (40%), Gaps = 5/151 (3%)
Query: 774 PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPP 833
P+ A T+ + H++ + K+ + E + A + + + EEP +PP
Sbjct: 285 PIPA-DTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPL---GQPP 340
Query: 834 LFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVIT 893
F + + V E ++L V P P + WY + + S I G L I
Sbjct: 341 RFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIA 400
Query: 894 NVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
E D+G Y C ASN G S A + I+
Sbjct: 401 EAFEE-DTGRYSCFASNIYGTDSTSAEIYIE 430
Score = 43.2 bits (97), Expect = 0.010
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G+PPPE+ W NG + D + + +E + I L + + Y A+N G +
Sbjct: 1167 VSGLPPPELTWLLNGQPVLPDAPHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN 1226
Query: 1655 SVEVTLKVYDKPSKPEGPVIMREI 1678
S + L V K K + PVI+ ++
Sbjct: 1227 SFSLELSVVAKEVK-KAPVILEKL 1249
Score = 42.7 bits (96), Expect = 0.014
Identities = 28/109 (25%), Positives = 47/109 (43%), Gaps = 7/109 (6%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S ++ YY+ E Q P + L++ ++L CI G+P P+V WY +GK+L+
Sbjct: 325 SSPSSLYYE---EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE 381
Query: 1524 TAKATY----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
+ + N Y C A N +G TS + I+
Sbjct: 382 NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 430
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/99 (33%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQN-----FDG 885
P+F Q ++ E + RV P P + WYR +I SP I Q +
Sbjct: 506 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 565
Query: 886 ENI-ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
E I LVI V +E DSG + C ASN G S A++ +
Sbjct: 566 EEICTLVIAEVFAE-DSGCFTCTASNKYGTVSSIAQLHV 603
Score = 42.7 bits (96), Expect = 0.014
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 1463 DASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
D S+ + I K +P +K LK+ + TC G+P PKV W++DGK++
Sbjct: 997 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 1056
Score = 41.5 bits (93), Expect = 0.032
Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 1106 PPEIITRLQNQKVNKGNKATFE-IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP +L++++V +G + + I + VRW+ +G E++ S I + G L
Sbjct: 339 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 398
Query: 1165 IYDCDLDDAGEYSCEVGN 1182
I + +D G YSC N
Sbjct: 399 IAEAFEEDTGRYSCFASN 416
Score = 38.3 bits (85), Expect = 0.30
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
I +P K L+N++ + + C G P PKV WYR+G
Sbjct: 503 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG 543
Score = 38.3 bits (85), Expect = 0.30
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNT 1650
T I GIP P+V W+K+G ++ E +E T + I+ YTI A+N
Sbjct: 1036 TCKIVGIPVPKVYWFKDGKQISKRNERCKMRREGDGTCSLHIESTTSDDDGNYTIMAANP 1095
Query: 1651 AGTSSVEVTLKVYDKP 1666
G S L V P
Sbjct: 1096 QGRISCSGHLMVQSLP 1111
Score = 37.1 bits (82), Expect = 0.69
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 11/113 (9%)
Query: 1561 TSCVVGIQQKPVITISN-EDIKQKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDK 1617
T+ + G+ KP+I + Q + LV ++G P P+V WY+ G +E+
Sbjct: 491 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 550
Query: 1618 EYNITTK--------EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ I K E+ + I E+ S +T ASN GT S L V
Sbjct: 551 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 603
Score = 35.9 bits (79), Expect = 1.6
Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 4/102 (3%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM--- 690
P F+K + EG ++ ECR+ P P + W +G I + + + M
Sbjct: 506 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 565
Query: 691 -YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE 731
L I V G +T A N+ G S L ++ E
Sbjct: 566 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 607
Score = 35.1 bits (77), Expect = 2.8
Identities = 45/191 (23%), Positives = 76/191 (39%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D E + L+ +++ ++ W +G+ + P + + L
Sbjct: 1144 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDAPHKMLVRETGVHSLL 1203
Query: 1076 IRNTSVHDEGEYSCILRDE----SCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y CI ++ S + E++V V+ P I+ +LQN V +G+ E
Sbjct: 1204 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1263
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQK-LKIYDCDLDDAGEYSC----EV 1180
+ + W KD I + I + D L I DAG Y+ E
Sbjct: 1264 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1323
Query: 1181 GNSKCTAILTV 1191
G CTA L +
Sbjct: 1324 GIVSCTARLDI 1334
>BC052969-1|AAH52969.1| 1465|Homo sapiens myomesin (M-protein) 2,
165kDa protein.
Length = 1465
Score = 144 bits (349), Expect = 3e-33
Identities = 111/403 (27%), Positives = 171/403 (42%), Gaps = 13/403 (3%)
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVE 1724
P P G V EISR V + W+PP G L Y IEK + W +V A
Sbjct: 511 PGPPTG-VHASEISRNYVVLSWEPPTPRGKDPLM-YFIEKSVVGSGSWQRVNAQTAVRSP 568
Query: 1725 TYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNES 1783
Y + L E Y+FRV++ N G SE E + PI + VPS S
Sbjct: 569 RYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQAQDVTVVPSAPGRVLASRNTKT-S 627
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXAR--IQKLSINTTYQFRIY 1840
V + W ++ Y V+ G W+ R + L+ Y FR+
Sbjct: 628 VVVQW--DRPKHEEDLLGYYVDCCVAGTNLWEPCNHKPIGYNRFVVHGLTTGEQYIFRVK 685
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
A N +G S D I + LT PS P + S+TL W P+ +GGSPI Y
Sbjct: 686 AVNAVGMSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSPILGY 745
Query: 1901 IIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRL 1959
++ + V K+W ++ + ++ + E F+I+A N G+ P++ S+ +
Sbjct: 746 YLDKREVHHKNWHEVNSSPSKPTILTVDGLMEGSLYEFKIAAVNLAGIGEPSDPSEHFKC 805
Query: 1960 EKHATVPSP-PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
E T+P P P L V ++ W P + G +P+ GY + R+ W+ V +
Sbjct: 806 EAW-TMPEPGPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDAGEWITVNQ 864
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
+ + DL + TY+ R+ A N G+ +P ++ EP V
Sbjct: 865 TTTASRYLKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLV 907
Score = 65.3 bits (152), Expect = 2e-09
Identities = 43/163 (26%), Positives = 71/163 (43%), Gaps = 9/163 (5%)
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
QP EW + ++K+ K TK ASL+ + D G+Y LR+ + G +D +
Sbjct: 311 QPRAEWYRDDVLLKESKWTKMFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVSDHSAFL 370
Query: 1376 TILDK----PSPPGKPNILEIDSSS---INICWDEPENTGNSTIIYYVVEYQEIDTTEWI 1428
+ D PG P L+ ++ + + W P T S ++ Y V+ E+ T W+
Sbjct: 371 FVRDADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWV 430
Query: 1429 SVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ + + + L SY FR AVN IS S ++
Sbjct: 431 QCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSD 473
Score = 64.5 bits (150), Expect = 4e-09
Identities = 56/224 (25%), Positives = 90/224 (40%), Gaps = 31/224 (13%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P + ++ V + W P + SP+ Y ++ V +W + + ++
Sbjct: 383 PGAPMDLQCHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWVQCNDAPVKICKY 442
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPT---------------ESQSVRLEKH-------- 1962
+ + E IFR+ A N+ G+S P+ Q+V LE
Sbjct: 443 PVTGLFEGRSYIFRVRAVNSAGISRPSRVSDAVAALDPLDLRRLQAVHLEGEKEIAIYQD 502
Query: 1963 -----ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV- 2016
A VP PPT + + N V+ SW P G PL+ Y I V W V
Sbjct: 503 DLEGDAQVPGPPTG-VHASEISRNYVVLSWEPPTPRGKDPLM-YFIEKSVVGSGSWQRVN 560
Query: 2017 GKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
+ V + ++ + DL E +Y+ R+ + N GLSEP E P +
Sbjct: 561 AQTAVRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQ 604
Score = 58.0 bits (134), Expect = 3e-07
Identities = 67/316 (21%), Positives = 116/316 (36%), Gaps = 46/316 (14%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXX 1539
++P + L++ T ++L G P P V WY+DG + A + R
Sbjct: 152 RAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGV 211
Query: 1540 XXXXX-------XXXYKCIAFNDHGEVETSCV-------------------VGIQQKPVI 1573
Y +A N HG+V T+ +G+ +I
Sbjct: 212 HTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMI 271
Query: 1574 TISNEDIKQKHKVGDEW-------------LVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
++ D++ K G + LVT ++ + P WY++ L+ K
Sbjct: 272 PYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQP-RAEWYRDDVLLKESKWTK 330
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP----SKPEGPVIMR 1676
+ E + + L + YT+ + G S L V D P P+ ++
Sbjct: 331 MFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVSDHSAFLFVRDADPLVTGAPGAPMDLQ 390
Query: 1677 --EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNEN 1734
+ +R+ V + WKPP + Y +++ E N W++ D + Y + L E
Sbjct: 391 CHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEG 450
Query: 1735 CEYMFRVIAQNPVGFS 1750
Y+FRV A N G S
Sbjct: 451 RSYIFRVRAVNSAGIS 466
Score = 57.2 bits (132), Expect = 6e-07
Identities = 43/177 (24%), Positives = 78/177 (44%), Gaps = 7/177 (3%)
Query: 1881 SVTLKWT---EPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEII 1937
+VTLK T P+ P + + +K WTK+ G ++ + DE +
Sbjct: 294 TVTLKCTMLVTPDLKRVQPRAEWYRDDVLLKESKWTKMFFGEGQA-SLSFSHLHKDDEGL 352
Query: 1938 FRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSN--IVMTSWGTPEWDGG 1995
+ + + GVS + VR + V P AP++++ +N V+ +W P
Sbjct: 353 YTLRIVSRGGVSDHSAFLFVR-DADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTE 411
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
+P++GY + +V W++ V K+ + L E +Y+ R+ A N G+S P
Sbjct: 412 SPVMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRP 468
Score = 55.2 bits (127), Expect = 2e-06
Identities = 61/305 (20%), Positives = 118/305 (38%), Gaps = 15/305 (4%)
Query: 1362 LENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
+ N +DV L PS P +L D S+ + W P+ +G S I+ Y ++ +E
Sbjct: 692 MSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSPILGYYLDKRE 751
Query: 1422 IDTTEWISVKNITKTQT--SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
+ W V + T ++ L S Y F+ AVN I + S+ +E++K T
Sbjct: 752 VHHKNWHEVNSSPSKPTILTVDGLMEGSLYEFKIAAVNLAGIGEPSDPSEHFKCEAWTMP 811
Query: 1480 Q-SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXX 1538
+ P + + + ++ G P ++ D ++ + N+
Sbjct: 812 EPGPAYDLTFCEVRDTSLVMLWKAPVYSG-SSPVSGYFVDFREEDAGEWITVNQTTTASR 870
Query: 1539 XXXXXXXXXYKCIAF-----NDHG---EVETSCVVGIQQKPVITISNEDIKQKHKVGDEW 1590
K F N +G +TS V ++ +P + + ++ G+ +
Sbjct: 871 YLKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVEARPGTKEISAGVDEQ---GNIY 927
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
L E + W K+ ++ +D+ + I T S + +K + Y++ S+T
Sbjct: 928 LGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGDHSKLYLKNPDKEDLGTYSVSVSDT 987
Query: 1651 AGTSS 1655
G SS
Sbjct: 988 DGVSS 992
Score = 54.8 bits (126), Expect = 3e-06
Identities = 57/239 (23%), Positives = 103/239 (43%), Gaps = 27/239 (11%)
Query: 493 DKLPVFEKPTSEEQ-SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIK 551
DKL +E+ T EE+ S AP + +LR + +V+ V+G+P P + W++ ++I
Sbjct: 137 DKL-AWERHTFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLIC 195
Query: 552 PSQDFQMYYDDDN--VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV------EAP 603
+ + Y + N V TL I +D T++ VA NA G S+ ++V E P
Sbjct: 196 QAAEPGKYRIESNYGVHTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEP 255
Query: 604 LSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIP-- 661
G + + LE TF + EG + L+C ++ P
Sbjct: 256 FRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRR--------EGETVTLKCTMLVTPDL 307
Query: 662 ---EPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
+P W ++ + ++ + + + + L +++ K EG YT+ V+R G
Sbjct: 308 KRVQPRAEW-YRDDVLLKESKWTKMFFGEGQ---ASLSFSHLHKDDEGLYTLRIVSRGG 362
Score = 51.2 bits (117), Expect = 4e-05
Identities = 24/78 (30%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNT 1650
+T + G P PEVIW+KN ++ + +++ ++ V + IK + S KY+I N
Sbjct: 1364 LTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGKYSINIKNK 1423
Query: 1651 AGTSSVEVTLKVYDKPSK 1668
G ++VT+ VY K
Sbjct: 1424 YGGEKIDVTVSVYKHGEK 1441
Score = 49.2 bits (112), Expect = 2e-04
Identities = 37/193 (19%), Positives = 78/193 (40%), Gaps = 5/193 (2%)
Query: 403 KRLNPFEIFYTP--VEVRCGDTVFAVYSYVAETDEAINLVEGERLYILDTSNQDWWYVQK 460
K +P ++ TP + ++C F V + + E + I + W + +
Sbjct: 1233 KSASPLKVLCTPEGIRLQCFMKYFTDEMKVNWCHKDAKISSSEHMRIGGSEEMAWLQICE 1292
Query: 461 HLTEEKGWVPAQYLMDENNYTQYLQ---KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLR 517
++KG + ++N+ + L + +E + F+ E++ +
Sbjct: 1293 PTEKDKGKYTFEIFDGKDNHQRSLDLSGQAFDEAFAEFQQFKAAAFAEKNRGRLIGGLPD 1352
Query: 518 PKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPED 577
+G T+ C V G P P++ WF+ I+ S+ F + + ++ I+ V ED
Sbjct: 1353 VVTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSED 1412
Query: 578 AGTFTCVAKNAAG 590
+G ++ KN G
Sbjct: 1413 SGKYSINIKNKYG 1425
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/155 (23%), Positives = 65/155 (41%), Gaps = 8/155 (5%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS-----SVEVTLKVYDKPSK 1668
+N E N ++ K +++ + L ++ I A N AG S + + P
Sbjct: 755 KNWHEVN-SSPSKPTILTVDGLMEGSLYEFKIAAVNLAGIGEPSDPSEHFKCEAWTMPEP 813
Query: 1669 -PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYC 1727
P + E+ S+ + WK P+ G ++ Y ++ E D WI V
Sbjct: 814 GPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDAGEWITVNQTTTASRYLK 873
Query: 1728 IQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIK 1761
+ L + Y+FRV A N G + + SEP++++
Sbjct: 874 VSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVE 908
Score = 44.4 bits (100), Expect = 0.005
Identities = 26/106 (24%), Positives = 50/106 (47%), Gaps = 8/106 (7%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P + EG + L C + P+P++ W ++I E+ SV +E ++ ++ +T+
Sbjct: 1351 PDVVTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTS 1410
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKI-KTGEK----EPPQVIEP 740
G Y++ N+ G + + + + K GEK PPQ +P
Sbjct: 1411 E---DSGKYSINIKNKYGGEKIDVTVSVYKHGEKIPDMAPPQQAKP 1453
Score = 42.3 bits (95), Expect = 0.018
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 842 ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD-GENIELVITNVDSEID 900
+T+ E T+ L V NP P + W++N++ I SE + + + + + I V SE D
Sbjct: 1354 VTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSE-D 1412
Query: 901 SGDYKCVASNSAGKSSHGARVTI 923
SG Y N G V++
Sbjct: 1413 SGKYSINIKNKYGGEKIDVTVSV 1435
Score = 41.1 bits (92), Expect = 0.042
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVK 1431
+VT++ PS PG+ +S+ + WD P++ ++ Y V+ T W + K
Sbjct: 607 DVTVV--PSAPGRVLASRNTKTSVVVQWDRPKH--EEDLLGYYVDCCVAGTNLWEPCNHK 662
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
I + + L T Y FR AVN V +S+ S+ ++ KV
Sbjct: 663 PIGYNRFVVHGLTTGEQYIFRVKAVNAVGMSENSQESDVIKV 704
Score = 41.1 bits (92), Expect = 0.042
Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 1/80 (1%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID-SKSASLTIKKVENTDAGI 1357
I G + L P P W N + I+ +H ++ +K S+TIK V + D+G
Sbjct: 1356 IMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGK 1415
Query: 1358 YKLRLENNCGHADVEMNVTI 1377
Y + ++N G +++ V++
Sbjct: 1416 YSINIKNKYGGEKIDVTVSV 1435
Score = 40.7 bits (91), Expect = 0.056
Identities = 28/102 (27%), Positives = 48/102 (47%), Gaps = 8/102 (7%)
Query: 827 EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII----SPSE-TITQ 881
E + P + R + TV E+ ++KL V P P + WY++ +I P + I
Sbjct: 148 ERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIES 207
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
N+ +E+ + D D+ Y VA+N+ G+ S A V +
Sbjct: 208 NYGVHTLEINRADFD---DTATYSAVATNAHGQVSTNAAVVV 246
Score = 40.3 bits (90), Expect = 0.074
Identities = 23/91 (25%), Positives = 42/91 (46%), Gaps = 4/91 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-- 1438
P PP + EI + + + W+ P G ++Y+ +E + + W V T ++
Sbjct: 511 PGPPTGVHASEISRNYVVLSWEPPTPRGKDPLMYF-IEKSVVGSGSWQRVNAQTAVRSPR 569
Query: 1439 -SIQNLKTNSSYRFRAYAVNEVDISDASETT 1468
++ +L SY FR + N +S+ SE T
Sbjct: 570 YAVFDLMEGKSYVFRVLSANRHGLSEPSEIT 600
Score = 39.1 bits (87), Expect = 0.17
Identities = 55/218 (25%), Positives = 88/218 (40%), Gaps = 36/218 (16%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV--KALPTK----SDGDTHS 788
P+++ L+S V + SV L V G P P + W K+ + A P K S+ H+
Sbjct: 154 PEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGVHT 213
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAVITV------EEPTEENAEP---PL----- 834
+ I + D Y+ A N+ G T+A + V EEP P PL
Sbjct: 214 LEINR-ADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMIP 272
Query: 835 -------FINRFQEITVKEKG---TIKLVARVT---RNPVPSITWYRNNEIISPSETITQ 881
F+ +F +T + +G T+K VT + P WYR++ ++ S+
Sbjct: 273 YTHFDVQFLEKF-GVTFRREGETVTLKCTMLVTPDLKRVQPRAEWYRDDVLLKESKWTKM 331
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
F L +++ + D G Y + G S H A
Sbjct: 332 FFGEGQASLSFSHLHKD-DEGLYTLRIVSRGGVSDHSA 368
Score = 38.3 bits (85), Expect = 0.30
Identities = 23/102 (22%), Positives = 50/102 (49%), Gaps = 4/102 (3%)
Query: 731 EKEPPQVIEPLKSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDT 786
EK ++I L ++ + +G+++ L+ V GNP P + W KN++ ++ K +
Sbjct: 1340 EKNRGRLIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAK 1399
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
+ +K +D G Y++ +N G + ++V + E+
Sbjct: 1400 YVSMTIKGVTSEDSGKYSINIKNKYGGEKIDVTVSVYKHGEK 1441
Score = 33.9 bits (74), Expect = 6.4
Identities = 51/238 (21%), Positives = 101/238 (42%), Gaps = 27/238 (11%)
Query: 695 LKITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
LK++++++ + + V AVN G + S P++++ + G KE + + + QG
Sbjct: 872 LKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVEARPGTKE-------ISAGVDEQG 924
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ TWCK+ + + + ++ GD HS LK +D G Y++
Sbjct: 925 NIYLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGD-HSKLYLKNPDKEDLGTYSVS 983
Query: 807 AENSEGIAETSAVITVEE------PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR-N 859
+++G++ +S V+ EE + E P + + + +KG ++ + +
Sbjct: 984 VSDTDGVS-SSFVLDPEELERLMALSNEIKNPTIPLKSELAYEIFDKGRVRFWLQAEHLS 1042
Query: 860 PVPSITWYRNNEIISPSETITQNFDGEN--IELVITNVDSEIDSGDYKCVASNSAGKS 915
P S + N+ +S SE D IE+V+ E + G Y + KS
Sbjct: 1043 PDASYRFIINDREVSDSEIHRIKCDKATGIIEMVMDRFSIE-NEGTYTVQIHDGKAKS 1099
Score = 33.9 bits (74), Expect = 6.4
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 1134 DALVRWFKDGSEIQFSNHIQLTID-GKKQKLKIYDCDLDDAGEYSCEVGN 1182
D V WFK+ +IQ S H + ++ K + I +D+G+YS + N
Sbjct: 1373 DPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGKYSINIKN 1422
>X69089-1|CAA48832.1| 1465|Homo sapiens 165kD protein protein.
Length = 1465
Score = 144 bits (348), Expect = 4e-33
Identities = 111/403 (27%), Positives = 171/403 (42%), Gaps = 13/403 (3%)
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVE 1724
P P G V EISR V + W+PP G L Y IEK + W +V A
Sbjct: 511 PGPPTG-VHASEISRNYVVLSWEPPTPRGKDPLM-YFIEKSVVGSGTWQRVNAQTAVRSP 568
Query: 1725 TYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNES 1783
Y + L E Y+FRV++ N G SE E + PI + VPS S
Sbjct: 569 RYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQAQDVTVVPSAPGRVLASRNTKT-S 627
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXAR--IQKLSINTTYQFRIY 1840
V + W ++ Y V+ G W+ R + L+ Y FR+
Sbjct: 628 VVVQW--DRPKHEEDLLGYYVDCCVAGTNLWEPCNHKPIGYNRFVVHGLTTGEQYIFRVK 685
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
A N +G S D I + LT PS P + S+TL W P+ +GGSPI Y
Sbjct: 686 AVNAVGMSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSPILGY 745
Query: 1901 IIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRL 1959
++ + V K+W ++ + ++ + E F+I+A N G+ P++ S+ +
Sbjct: 746 YLDKREVHHKNWHEVNSSPSKPTILTVDGLTEGSLYEFKIAAVNLAGIGEPSDPSEHFKC 805
Query: 1960 EKHATVPSP-PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
E T+P P P L V ++ W P + G +P+ GY + R+ W+ V +
Sbjct: 806 EAW-TMPEPGPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDAGEWITVDQ 864
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
+ + DL + TY+ R+ A N G+ +P ++ EP V
Sbjct: 865 TTTASRYLKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLV 907
Score = 64.9 bits (151), Expect = 3e-09
Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 9/163 (5%)
Query: 1316 QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
QP EW + ++K+ K TK ASL+ + D G+Y LR+ + G D +
Sbjct: 311 QPRAEWYRDDLLLKESKWTKMFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVTDHSAFL 370
Query: 1376 TILDK----PSPPGKPNILEIDSSS---INICWDEPENTGNSTIIYYVVEYQEIDTTEWI 1428
+ D PG P L+ ++ + + W P T S ++ Y V+ E+ T W+
Sbjct: 371 FVRDADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWV 430
Query: 1429 SVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ + + + L SY FR AVN IS S ++
Sbjct: 431 QCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSD 473
Score = 64.5 bits (150), Expect = 4e-09
Identities = 56/224 (25%), Positives = 90/224 (40%), Gaps = 31/224 (13%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P + ++ V + W P + SP+ Y ++ V +W + + ++
Sbjct: 383 PGAPMDLQCHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWVQCNDAPVKICKY 442
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPT---------------ESQSVRLEKH-------- 1962
+ + E IFR+ A N+ G+S P+ Q+V LE
Sbjct: 443 PVTGLFEGRSYIFRVRAVNSAGISRPSRVSDAVAALDPLDLRRLQAVHLEGEKEIAIYQD 502
Query: 1963 -----ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV- 2016
A VP PPT + + N V+ SW P G PL+ Y I V W V
Sbjct: 503 DLEGDAQVPGPPTG-VHASEISRNYVVLSWEPPTPRGKDPLM-YFIEKSVVGSGTWQRVN 560
Query: 2017 GKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
+ V + ++ + DL E +Y+ R+ + N GLSEP E P +
Sbjct: 561 AQTAVRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQ 604
Score = 56.8 bits (131), Expect = 8e-07
Identities = 66/316 (20%), Positives = 116/316 (36%), Gaps = 46/316 (14%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXX 1539
++P + L++ T ++L G P P V WY+DG + A + R
Sbjct: 152 RAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGV 211
Query: 1540 XXXXX-------XXXYKCIAFNDHGEVETSCV-------------------VGIQQKPVI 1573
Y +A N HG+V T+ +G+ +I
Sbjct: 212 HTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMI 271
Query: 1574 TISNEDIKQKHKVGDEW-------------LVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
++ D++ K G + LVT ++ + P WY++ L+ K
Sbjct: 272 PYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQP-RAEWYRDDLLLKESKWTK 330
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP----SKPEGPVIMR 1676
+ E + + L + YT+ + G + L V D P P+ ++
Sbjct: 331 MFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVTDHSAFLFVRDADPLVTGAPGAPMDLQ 390
Query: 1677 --EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNEN 1734
+ +R+ V + WKPP + Y +++ E N W++ D + Y + L E
Sbjct: 391 CHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEG 450
Query: 1735 CEYMFRVIAQNPVGFS 1750
Y+FRV A N G S
Sbjct: 451 RSYIFRVRAVNSAGIS 466
Score = 56.0 bits (129), Expect = 1e-06
Identities = 42/177 (23%), Positives = 78/177 (44%), Gaps = 7/177 (3%)
Query: 1881 SVTLKWT---EPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEII 1937
+VTLK T P+ P + + +K WTK+ G ++ + DE +
Sbjct: 294 TVTLKCTMLVTPDLKRVQPRAEWYRDDLLLKESKWTKMFFGEGQA-SLSFSHLHKDDEGL 352
Query: 1938 FRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSN--IVMTSWGTPEWDGG 1995
+ + + GV+ + VR + V P AP++++ +N V+ +W P
Sbjct: 353 YTLRIVSRGGVTDHSAFLFVR-DADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTE 411
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
+P++GY + +V W++ V K+ + L E +Y+ R+ A N G+S P
Sbjct: 412 SPVMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRP 468
Score = 54.4 bits (125), Expect = 4e-06
Identities = 57/239 (23%), Positives = 103/239 (43%), Gaps = 27/239 (11%)
Query: 493 DKLPVFEKPTSEEQ-SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIK 551
DKL +E+ T EE+ S AP + +LR + +V+ V+G+P P + W++ ++I
Sbjct: 137 DKL-AWERHTFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLIC 195
Query: 552 PSQDFQMYYDDDN--VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV------EAP 603
+ + Y + N V TL I +D T++ VA NA G S+ ++V E P
Sbjct: 196 QAAEPGKYRIESNYGVHTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEP 255
Query: 604 LSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIP-- 661
G + + LE TF + EG + L+C ++ P
Sbjct: 256 FRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRR--------EGETVTLKCTMLVTPDL 307
Query: 662 ---EPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG 717
+P W ++ + ++ + + + + L +++ K EG YT+ V+R G
Sbjct: 308 KRVQPRAEW-YRDDLLLKESKWTKMFFGEGQ---ASLSFSHLHKDDEGLYTLRIVSRGG 362
Score = 54.4 bits (125), Expect = 4e-06
Identities = 62/306 (20%), Positives = 121/306 (39%), Gaps = 17/306 (5%)
Query: 1362 LENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
+ N +DV L PS P +L D S+ + W P+ +G S I+ Y ++ +E
Sbjct: 692 MSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSPILGYYLDKRE 751
Query: 1422 IDTTEWISVKNITKTQT--SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
+ W V + T ++ L S Y F+ AVN I + S+ +E++K T
Sbjct: 752 VHHKNWHEVNSSPSKPTILTVDGLTEGSLYEFKIAAVNLAGIGEPSDPSEHFKCEAWTMP 811
Query: 1480 Q-SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD------GKKLKTAKATYENR 1532
+ P + + + ++ G P ++ D G+ + + T +R
Sbjct: 812 EPGPAYDLTFCEVRDTSLVMLWKAPVYSG-SSPVSGYFVDFREEDAGEWITVDQTTTASR 870
Query: 1533 XXXXXXXXXXXXXXXYKCIAFNDHG---EVETSCVVGIQQKPVITISNEDIKQKHKVGDE 1589
++ A N +G +TS V ++ +P + + ++ G+
Sbjct: 871 -YLKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVEARPGTKEISAGVDEQ---GNI 926
Query: 1590 WLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
+L E + W K+ ++ +D+ + I T S + +K + Y++ S+
Sbjct: 927 YLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGDHSKLYLKNPDKEDLGTYSVSVSD 986
Query: 1650 TAGTSS 1655
T G SS
Sbjct: 987 TDGVSS 992
Score = 51.2 bits (117), Expect = 4e-05
Identities = 24/78 (30%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNT 1650
+T + G P PEVIW+KN ++ + +++ ++ V + IK + S KY+I N
Sbjct: 1364 LTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGKYSINIKNK 1423
Query: 1651 AGTSSVEVTLKVYDKPSK 1668
G ++VT+ VY K
Sbjct: 1424 YGGEKIDVTVSVYKHGEK 1441
Score = 49.2 bits (112), Expect = 2e-04
Identities = 37/193 (19%), Positives = 78/193 (40%), Gaps = 5/193 (2%)
Query: 403 KRLNPFEIFYTP--VEVRCGDTVFAVYSYVAETDEAINLVEGERLYILDTSNQDWWYVQK 460
K +P ++ TP + ++C F V + + E + I + W + +
Sbjct: 1233 KSASPLKVLCTPEGIRLQCFMKYFTDEMKVNWCHKDAKISSSEHMRIGGSEEMAWLQICE 1292
Query: 461 HLTEEKGWVPAQYLMDENNYTQYLQ---KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLR 517
++KG + ++N+ + L + +E + F+ E++ +
Sbjct: 1293 PTEKDKGKYTFEIFDGKDNHQRSLDLSGQAFDEAFAEFQQFKAAAFAEKNRGRLIGGLPD 1352
Query: 518 PKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPED 577
+G T+ C V G P P++ WF+ I+ S+ F + + ++ I+ V ED
Sbjct: 1353 VVTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSED 1412
Query: 578 AGTFTCVAKNAAG 590
+G ++ KN G
Sbjct: 1413 SGKYSINIKNKYG 1425
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/155 (23%), Positives = 65/155 (41%), Gaps = 8/155 (5%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS-----SVEVTLKVYDKPSK 1668
+N E N ++ K +++ + L ++ I A N AG S + + P
Sbjct: 755 KNWHEVN-SSPSKPTILTVDGLTEGSLYEFKIAAVNLAGIGEPSDPSEHFKCEAWTMPEP 813
Query: 1669 -PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYC 1727
P + E+ S+ + WK P+ G ++ Y ++ E D WI V
Sbjct: 814 GPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDAGEWITVDQTTTASRYLK 873
Query: 1728 IQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIK 1761
+ L + Y+FRV A N G + + SEP++++
Sbjct: 874 VSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVE 908
Score = 44.4 bits (100), Expect = 0.005
Identities = 26/106 (24%), Positives = 50/106 (47%), Gaps = 8/106 (7%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P + EG + L C + P+P++ W ++I E+ SV +E ++ ++ +T+
Sbjct: 1351 PDVVTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTS 1410
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKI-KTGEK----EPPQVIEP 740
G Y++ N+ G + + + + K GEK PPQ +P
Sbjct: 1411 E---DSGKYSINIKNKYGGEKIDVTVSVYKHGEKIPDMAPPQQAKP 1453
Score = 42.3 bits (95), Expect = 0.018
Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 842 ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD-GENIELVITNVDSEID 900
+T+ E T+ L V NP P + W++N++ I SE + + + + + I V SE D
Sbjct: 1354 VTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSE-D 1412
Query: 901 SGDYKCVASNSAGKSSHGARVTI 923
SG Y N G V++
Sbjct: 1413 SGKYSINIKNKYGGEKIDVTVSV 1435
Score = 41.1 bits (92), Expect = 0.042
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVK 1431
+VT++ PS PG+ +S+ + WD P++ ++ Y V+ T W + K
Sbjct: 607 DVTVV--PSAPGRVLASRNTKTSVVVQWDRPKH--EEDLLGYYVDCCVAGTNLWEPCNHK 662
Query: 1432 NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
I + + L T Y FR AVN V +S+ S+ ++ KV
Sbjct: 663 PIGYNRFVVHGLTTGEQYIFRVKAVNAVGMSENSQESDVIKV 704
Score = 41.1 bits (92), Expect = 0.042
Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 1/80 (1%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID-SKSASLTIKKVENTDAGI 1357
I G + L P P W N + I+ +H ++ +K S+TIK V + D+G
Sbjct: 1356 IMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGK 1415
Query: 1358 YKLRLENNCGHADVEMNVTI 1377
Y + ++N G +++ V++
Sbjct: 1416 YSINIKNKYGGEKIDVTVSV 1435
Score = 40.7 bits (91), Expect = 0.056
Identities = 28/102 (27%), Positives = 48/102 (47%), Gaps = 8/102 (7%)
Query: 827 EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII----SPSE-TITQ 881
E + P + R + TV E+ ++KL V P P + WY++ +I P + I
Sbjct: 148 ERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIES 207
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
N+ +E+ + D D+ Y VA+N+ G+ S A V +
Sbjct: 208 NYGVHTLEINRADFD---DTATYSAVATNAHGQVSTNAAVVV 246
Score = 39.9 bits (89), Expect = 0.098
Identities = 23/91 (25%), Positives = 42/91 (46%), Gaps = 4/91 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-- 1438
P PP + EI + + + W+ P G ++Y+ +E + + W V T ++
Sbjct: 511 PGPPTGVHASEISRNYVVLSWEPPTPRGKDPLMYF-IEKSVVGSGTWQRVNAQTAVRSPR 569
Query: 1439 -SIQNLKTNSSYRFRAYAVNEVDISDASETT 1468
++ +L SY FR + N +S+ SE T
Sbjct: 570 YAVFDLMEGKSYVFRVLSANRHGLSEPSEIT 600
Score = 38.3 bits (85), Expect = 0.30
Identities = 23/102 (22%), Positives = 50/102 (49%), Gaps = 4/102 (3%)
Query: 731 EKEPPQVIEPLKSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDT 786
EK ++I L ++ + +G+++ L+ V GNP P + W KN++ ++ K +
Sbjct: 1340 EKNRGRLIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAK 1399
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
+ +K +D G Y++ +N G + ++V + E+
Sbjct: 1400 YVSMTIKGVTSEDSGKYSINIKNKYGGEKIDVTVSVYKHGEK 1441
Score = 37.5 bits (83), Expect = 0.52
Identities = 54/218 (24%), Positives = 88/218 (40%), Gaps = 36/218 (16%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV--KALPTK----SDGDTHS 788
P+++ L+S V + SV L V G P P + W K+ + A P K S+ H+
Sbjct: 154 PEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGVHT 213
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAVITV------EEPTEENAEP---PL----- 834
+ I + D Y+ A N+ G T+A + V EEP P PL
Sbjct: 214 LEINR-ADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMIP 272
Query: 835 -------FINRFQEITVKEKG---TIKLVARVT---RNPVPSITWYRNNEIISPSETITQ 881
F+ +F +T + +G T+K VT + P WYR++ ++ S+
Sbjct: 273 YTHFDVQFLEKF-GVTFRREGETVTLKCTMLVTPDLKRVQPRAEWYRDDLLLKESKWTKM 331
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
F L +++ + D G Y + G + H A
Sbjct: 332 FFGEGQASLSFSHLHKD-DEGLYTLRIVSRGGVTDHSA 368
Score = 33.9 bits (74), Expect = 6.4
Identities = 51/238 (21%), Positives = 101/238 (42%), Gaps = 27/238 (11%)
Query: 695 LKITNVKKFQEGTYTVVAVNREG-----EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
LK++++++ + + V AVN G + S P++++ + G KE + + + QG
Sbjct: 872 LKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVEARPGTKE-------ISAGVDEQG 924
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ TWCK+ + + + ++ GD HS LK +D G Y++
Sbjct: 925 NIYLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGD-HSKLYLKNPDKEDLGTYSVS 983
Query: 807 AENSEGIAETSAVITVEE------PTEENAEPPLFINRFQEITVKEKGTIKLVARVTR-N 859
+++G++ +S V+ EE + E P + + + +KG ++ + +
Sbjct: 984 VSDTDGVS-SSFVLDPEELERLMALSNEIKNPTIPLKSELAYEIFDKGRVRFWLQAEHLS 1042
Query: 860 PVPSITWYRNNEIISPSETITQNFDGEN--IELVITNVDSEIDSGDYKCVASNSAGKS 915
P S + N+ +S SE D IE+V+ E + G Y + KS
Sbjct: 1043 PDASYRFIINDREVSDSEIHRIKCDKATGIIEMVMDRFSIE-NEGTYTVQIHDGKAKS 1099
Score = 33.9 bits (74), Expect = 6.4
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 1134 DALVRWFKDGSEIQFSNHIQLTID-GKKQKLKIYDCDLDDAGEYSCEVGN 1182
D V WFK+ +IQ S H + ++ K + I +D+G+YS + N
Sbjct: 1373 DPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGKYSINIKN 1422
>Y10129-1|CAA71216.1| 1274|Homo sapiens myosin binding protein C gene
protein.
Length = 1274
Score = 139 bits (337), Expect = 9e-32
Identities = 114/462 (24%), Positives = 200/462 (43%), Gaps = 28/462 (6%)
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASL-TIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+DEW+ + K++ + + +K S+ T++ E D G+Y + ++N G V + V
Sbjct: 708 SDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVK 767
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--IT 1434
++D P P P I + S + W+ P G I+ Y++E ++ + W+ + I
Sbjct: 768 VIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMQLNFDLIQ 827
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI----KETKIQSPTVEKPLKN 1490
+ + + Y R YAVN + +S S ++ + I + T + V +
Sbjct: 828 ELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTVS 887
Query: 1491 ITTEPNEDIELTCIFGGVPQPKVTWYRDG-KKLKTAKATYENRXXXXXXXXXXXXXXXYK 1549
+ P E + GG+ V + +G + A ++
Sbjct: 888 LKWRPPERVGA----GGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFR 943
Query: 1550 CIAFNDHGE---VETSCVVGIQ---QKPVITISNEDIKQ--KHKVGDEWLVTAVIEGIPP 1601
A N G V T+ V +Q Q+P + + ++Q + KVG+ + +G P
Sbjct: 944 VRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRH-LRQTIQKKVGEPVNLLIPFQGKPR 1002
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P+V W K G L + E +I +++ I+ +R HS Y + + L+
Sbjct: 1003 PQVTWTKEGQPLAGE-EVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQ 1061
Query: 1662 VYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
V DKPS P+ + + + +V +EWKPP D G EL Y ++K + W V + R
Sbjct: 1062 VVDKPSPPQ-DLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYR 1120
Query: 1722 DVETYC-IQKLNENCEYMFRVIAQNPVGFSE--ALESEPIVI 1760
T+C + +L Y FRV +QN VGFS+ A EP+ I
Sbjct: 1121 --RTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFI 1160
Score = 116 bits (279), Expect = 9e-25
Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 10/257 (3%)
Query: 1019 FIRKLQD-FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
F +KL+ ++V + L VE+ A+V W ++G+ I+ +KY FE G R L I
Sbjct: 365 FQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTIS 424
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR-LQNQKVNKGNKATFEIELTKGDAL 1136
S+ D+ Y C++ E C+ E+ V E PP +ITR L++Q V G + FE E+++ A
Sbjct: 425 QCSLADDAAYQCVVGGEKCSTELFVKE-PPVLITRPLEDQLVMVGQRVEFECEVSEEGAQ 483
Query: 1137 VRWFKDGSEIQFSNHIQLTI--DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEP 1194
V+W KDG E+ + DG++ L I + L+DAG Y+ + A L V+E
Sbjct: 484 VKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEK 543
Query: 1195 SINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK-KSVIEDTE-KFTLISDVKKRT 1252
+ + + ++V A A E+ DE + W K K ++ D+ K + I V K
Sbjct: 544 KLEVYQSIAD-LMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHK-- 600
Query: 1253 LIIRKCTEDDQCEYTCV 1269
L I T D+ +Y+ V
Sbjct: 601 LTIDDVTPADEADYSFV 617
Score = 111 bits (268), Expect = 2e-23
Identities = 109/468 (23%), Positives = 195/468 (41%), Gaps = 38/468 (8%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
E + + T + S+ ++ ++ YT+ N G V +T+KV D P P P
Sbjct: 720 ETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPK 779
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVETYCIQKLN 1732
I + +S T++W+PP DGG + Y +E+ + + RW+++ D+ +++ ++ +++
Sbjct: 780 ISN-VGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMQLNFDLIQEL-SHEARRMI 837
Query: 1733 ENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPS 1791
E Y RV A N +G S + S+P + + PS + + +V + W P
Sbjct: 838 EGVVYEMRVYAVNAIGMSRPSPASQPFM---PIGPPS-EPTHLAVEDVSDTTVSLKWRPP 893
Query: 1792 EKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARI--QKLSINTTYQFRIYARNEIGTS 1848
E+ G + Y VE EG +W I + L FR+ A N G
Sbjct: 894 ERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPG 953
Query: 1849 LPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEF--KT 1906
P T+ + +T+ + L P + ++ + V G P+ N +I F K
Sbjct: 954 APVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKV-----------GEPV-NLLIPFQGKP 1001
Query: 1907 VKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISA----ENTVGVSLPTESQSVRLEK 1961
+WTK + G E I N D I+F +A T V++ E+ +
Sbjct: 1002 RPQVTWTKEGQPLAG--EEVSIRN-SPTDTILFIRAARRVHSGTYQVTVRIENMEDKATL 1058
Query: 1962 HATVPSPPTAPLEIRMV---GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
V P+ P ++R+ G N+ + W P+ G L GY + D W V +
Sbjct: 1059 VLQVVDKPSPPQDLRVTDAWGLNVAL-EWKPPQDVGNTELWGYTVQKADKKTMEWFTVLE 1117
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEG 2066
+ +L + Y R++++N +G S+ + + IP G
Sbjct: 1118 -HYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPRPG 1164
Score = 100 bits (240), Expect = 5e-20
Identities = 78/284 (27%), Positives = 123/284 (43%), Gaps = 6/284 (2%)
Query: 924 DVEKVT-FVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQE-GR 980
D +K T F K L+ +Y+ +G + L + + H KW N +EI + I + G
Sbjct: 358 DEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGA 417
Query: 981 XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D +C+V ++ ST L VKE R L+D V E E+
Sbjct: 418 KRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEV 477
Query: 1041 NSETADVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
+ E A V W +DG E+ + + KY F+K G L I + D G Y+ AE
Sbjct: 478 SEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAE 537
Query: 1100 VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGK 1159
+ V E E+ + + V ++A F+ E++ + W K+G E+ + I+++ G+
Sbjct: 538 LIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGR 597
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKC--TAILTVEEPSINFTLR 1201
KL I D D +YS C +A L E I+F R
Sbjct: 598 VHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPR 641
Score = 83.4 bits (197), Expect = 8e-15
Identities = 60/239 (25%), Positives = 106/239 (44%), Gaps = 19/239 (7%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
K G V LL+ +Q P+P W + + + L I+ +G Y+
Sbjct: 986 KVGEPVNLLIPFQGKPRPQVTWTKEGQPLAG-EEVSIRNSPTDTILFIRAARRVHSGTYQ 1044
Query: 1360 L--RLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
+ R+EN A + + V +DKPSPP + + ++ + W P++ GN+ + Y V
Sbjct: 1045 VTVRIENMEDKATLVLQV--VDKPSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTV 1102
Query: 1418 EYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ + T EW +V ++ +T + L + Y FR ++ N V SD + TT+ I
Sbjct: 1103 QKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPR 1162
Query: 1477 TKI-------------QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
I ++P+ +PL N + L C G P+PK++W+++G L
Sbjct: 1163 PGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDL 1221
Score = 80.6 bits (190), Expect = 6e-14
Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 8/155 (5%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTS 1986
+E +++DE ++ ++ +N VG E Q K VP P AP +I VG +
Sbjct: 738 VEGAEKEDEGVYTVTVKNPVG-----EDQVNLTVKVIDVPDAPAAP-KISNVGEDSCTVQ 791
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P +DGG P+LGY + + WM++ + L R + E Y +R+YA N
Sbjct: 792 WEPPAYDGGQPILGYILERKKKKSYRWMQLNFDLIQELSHEARRMIEGVVYEMRVYAVNA 851
Query: 2047 IGLSEPLESDEPFKVI--PGEGSHADEEPGEQTEV 2079
IG+S P + +PF I P E +H E T V
Sbjct: 852 IGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTV 886
Score = 56.4 bits (130), Expect = 1e-06
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 1/97 (1%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F + L + G T C V G P+P+I+WF+ + F+M + V
Sbjct: 1178 SEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRM-FSKQGVL 1236
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
TL IR+ P D G + C A N G A L V P
Sbjct: 1237 TLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVP 1273
Score = 46.4 bits (105), Expect = 0.001
Identities = 26/77 (33%), Positives = 37/77 (48%)
Query: 1117 KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY 1176
+V G+ A FE E + VRW + GS+I SN L +G + L + + D G Y
Sbjct: 20 EVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSY 79
Query: 1177 SCEVGNSKCTAILTVEE 1193
+ G+SK L V E
Sbjct: 80 AVIAGSSKVKFDLKVIE 96
Score = 44.8 bits (101), Expect = 0.003
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 4/101 (3%)
Query: 1192 EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKK 1250
E+ S F +L V LTVE+ D +V W K I+ + K+ S K
Sbjct: 359 EKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAK 418
Query: 1251 RTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
RTL I +C+ D Y CV+ K +T+L V+ PP ++
Sbjct: 419 RTLTISQCSLADDAAYQCVVGGEKCSTEL---FVKEPPVLI 456
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/92 (27%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 1013 KETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
K+ + F +K + EV A+ E E V W+R G I NKY G
Sbjct: 6 KKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISAS-NKYGLATEGTRH 64
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
L +R D+G Y+ I ++ V+E
Sbjct: 65 TLTVREVGPADQGSYAVIAGSSKVKFDLKVIE 96
Score = 40.3 bits (90), Expect = 0.074
Identities = 18/72 (25%), Positives = 34/72 (47%)
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
++ + G P P++ W+KNG L D + + +K+ + I++ Y A+N
Sbjct: 1199 MLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNL 1258
Query: 1651 AGTSSVEVTLKV 1662
G + E L+V
Sbjct: 1259 QGEARCECRLEV 1270
Score = 39.9 bits (89), Expect = 0.098
Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 4/96 (4%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSI 789
E P +PL + V G + +L V G+P+P I+W KN + S ++
Sbjct: 1179 EAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTL 1238
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
I KP D G+Y +A N +G A + V P
Sbjct: 1239 EIRKPCPF-DGGIYVCRATNLQGEARCECRLEVRVP 1273
Score = 37.9 bits (84), Expect = 0.39
Identities = 43/177 (24%), Positives = 72/177 (40%), Gaps = 22/177 (12%)
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV----AVNREGEASLP 722
WL G+E+VPD I V+ +H L I +V E Y+ V A N +
Sbjct: 577 WLKNGKELVPDSRIKVSHIGRVHK----LTIDDVTPADEADYSFVPEGFACNLSAKLHFM 632
Query: 723 IVLKIKTGEKEPPQVIEPL-----KSMIVRQGESVILSAQVVGNPRPTITWCK-----NN 772
V +EPP++ +++V G + L + G+P PT+ W K N
Sbjct: 633 EVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNK 692
Query: 773 KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
P + P + S + KK+ E ++ E + + ++ TVE +E+
Sbjct: 693 APARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETT----KDRSIFTVEGAEKED 745
Score = 36.3 bits (80), Expect = 1.2
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVY--TL 805
GE V L G PRP +TW K +P+ + T +I ++ + G Y T+
Sbjct: 988 GEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRVHSGTYQVTV 1047
Query: 806 KAENSEGIAETSAVITVEEPT 826
+ EN E A T + V++P+
Sbjct: 1048 RIENMEDKA-TLVLQVVDKPS 1067
>X84075-1|CAA58882.1| 1274|Homo sapiens cardiac myosin-binding protein
C protein.
Length = 1274
Score = 139 bits (337), Expect = 9e-32
Identities = 114/462 (24%), Positives = 200/462 (43%), Gaps = 28/462 (6%)
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASL-TIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+DEW+ + K++ + + +K S+ T++ E D G+Y + ++N G V + V
Sbjct: 708 SDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVK 767
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--IT 1434
++D P P P I + S + W+ P G I+ Y++E ++ + W+ + I
Sbjct: 768 VIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMQLNFDLIQ 827
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI----KETKIQSPTVEKPLKN 1490
+ + + Y R YAVN + +S S ++ + I + T + V +
Sbjct: 828 ELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTVS 887
Query: 1491 ITTEPNEDIELTCIFGGVPQPKVTWYRDG-KKLKTAKATYENRXXXXXXXXXXXXXXXYK 1549
+ P E + GG+ V + +G + A ++
Sbjct: 888 LKWRPPERVGA----GGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFR 943
Query: 1550 CIAFNDHGE---VETSCVVGIQ---QKPVITISNEDIKQ--KHKVGDEWLVTAVIEGIPP 1601
A N G V T+ V +Q Q+P + + ++Q + KVG+ + +G P
Sbjct: 944 VRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRH-LRQTIQKKVGEPVNLLIPFQGKPR 1002
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P+V W K G L + E +I +++ I+ +R HS Y + + L+
Sbjct: 1003 PQVTWTKEGQPLAGE-EVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQ 1061
Query: 1662 VYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
V DKPS P+ + + + +V +EWKPP D G EL Y ++K + W V + R
Sbjct: 1062 VVDKPSPPQ-DLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYR 1120
Query: 1722 DVETYC-IQKLNENCEYMFRVIAQNPVGFSE--ALESEPIVI 1760
T+C + +L Y FRV +QN VGFS+ A EP+ I
Sbjct: 1121 --RTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFI 1160
Score = 114 bits (274), Expect = 4e-24
Identities = 80/257 (31%), Positives = 129/257 (50%), Gaps = 10/257 (3%)
Query: 1019 FIRKLQD-FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
F +KL+ ++V + L VE+ A+V W ++G+ I+ +KY FE G R L I
Sbjct: 365 FQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTIS 424
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR-LQNQKVNKGNKATFEIELTKGDAL 1136
S+ D+ Y C++ E C+ E+ V E PP +ITR L++Q V G + FE E+++ A
Sbjct: 425 QCSLADDAAYQCVVGGEKCSTELFVKE-PPVLITRPLEDQLVMVGQRVEFECEVSEEGAQ 483
Query: 1137 VRWFKDGSEIQFSNHIQLTI--DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEP 1194
V+W KDG E+ + DG++ L I + L+DAG Y+ + L V+E
Sbjct: 484 VKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALRELIVQEK 543
Query: 1195 SINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK-KSVIEDTE-KFTLISDVKKRT 1252
+ + + ++V A A E+ DE + W K K ++ D+ K + I V K
Sbjct: 544 KLEVYQSIAD-LMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHK-- 600
Query: 1253 LIIRKCTEDDQCEYTCV 1269
L I T D+ +Y+ V
Sbjct: 601 LTIDDVTPADEADYSFV 617
Score = 111 bits (268), Expect = 2e-23
Identities = 109/468 (23%), Positives = 195/468 (41%), Gaps = 38/468 (8%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
E + + T + S+ ++ ++ YT+ N G V +T+KV D P P P
Sbjct: 720 ETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPK 779
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVETYCIQKLN 1732
I + +S T++W+PP DGG + Y +E+ + + RW+++ D+ +++ ++ +++
Sbjct: 780 ISN-VGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMQLNFDLIQEL-SHEARRMI 837
Query: 1733 ENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPS 1791
E Y RV A N +G S + S+P + + PS + + +V + W P
Sbjct: 838 EGVVYEMRVYAVNAIGMSRPSPASQPFM---PIGPPS-EPTHLAVEDVSDTTVSLKWRPP 893
Query: 1792 EKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARI--QKLSINTTYQFRIYARNEIGTS 1848
E+ G + Y VE EG +W I + L FR+ A N G
Sbjct: 894 ERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPG 953
Query: 1849 LPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEF--KT 1906
P T+ + +T+ + L P + ++ + V G P+ N +I F K
Sbjct: 954 APVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKV-----------GEPV-NLLIPFQGKP 1001
Query: 1907 VKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISA----ENTVGVSLPTESQSVRLEK 1961
+WTK + G E I N D I+F +A T V++ E+ +
Sbjct: 1002 RPQVTWTKEGQPLAG--EEVSIRN-SPTDTILFIRAARRVHSGTYQVTVRIENMEDKATL 1058
Query: 1962 HATVPSPPTAPLEIRMV---GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
V P+ P ++R+ G N+ + W P+ G L GY + D W V +
Sbjct: 1059 VLQVVDKPSPPQDLRVTDAWGLNVAL-EWKPPQDVGNTELWGYTVQKADKKTMEWFTVLE 1117
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEG 2066
+ +L + Y R++++N +G S+ + + IP G
Sbjct: 1118 -HYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPRPG 1164
Score = 98.7 bits (235), Expect = 2e-19
Identities = 77/284 (27%), Positives = 122/284 (42%), Gaps = 6/284 (2%)
Query: 924 DVEKVT-FVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQE-GR 980
D +K T F K L+ +Y+ +G + L + + H KW N +EI + I + G
Sbjct: 358 DEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGA 417
Query: 981 XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D +C+V ++ ST L VKE R L+D V E E+
Sbjct: 418 KRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEV 477
Query: 1041 NSETADVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
+ E A V W +DG E+ + + KY F+K G L I + D G Y+ E
Sbjct: 478 SEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALRE 537
Query: 1100 VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGK 1159
+ V E E+ + + V ++A F+ E++ + W K+G E+ + I+++ G+
Sbjct: 538 LIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGR 597
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKC--TAILTVEEPSINFTLR 1201
KL I D D +YS C +A L E I+F R
Sbjct: 598 VHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPR 641
Score = 83.4 bits (197), Expect = 8e-15
Identities = 60/239 (25%), Positives = 106/239 (44%), Gaps = 19/239 (7%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
K G V LL+ +Q P+P W + + + L I+ +G Y+
Sbjct: 986 KVGEPVNLLIPFQGKPRPQVTWTKEGQPLAG-EEVSIRNSPTDTILFIRAARRVHSGTYQ 1044
Query: 1360 L--RLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
+ R+EN A + + V +DKPSPP + + ++ + W P++ GN+ + Y V
Sbjct: 1045 VTVRIENMEDKATLVLQV--VDKPSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTV 1102
Query: 1418 EYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ + T EW +V ++ +T + L + Y FR ++ N V SD + TT+ I
Sbjct: 1103 QKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPR 1162
Query: 1477 TKI-------------QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
I ++P+ +PL N + L C G P+PK++W+++G L
Sbjct: 1163 PGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDL 1221
Score = 80.6 bits (190), Expect = 6e-14
Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 8/155 (5%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTS 1986
+E +++DE ++ ++ +N VG E Q K VP P AP +I VG +
Sbjct: 738 VEGAEKEDEGVYTVTVKNPVG-----EDQVNLTVKVIDVPDAPAAP-KISNVGEDSCTVQ 791
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P +DGG P+LGY + + WM++ + L R + E Y +R+YA N
Sbjct: 792 WEPPAYDGGQPILGYILERKKKKSYRWMQLNFDLIQELSHEARRMIEGVVYEMRVYAVNA 851
Query: 2047 IGLSEPLESDEPFKVI--PGEGSHADEEPGEQTEV 2079
IG+S P + +PF I P E +H E T V
Sbjct: 852 IGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTV 886
Score = 56.4 bits (130), Expect = 1e-06
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 1/97 (1%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F + L + G T C V G P+P+I+WF+ + F+M + V
Sbjct: 1178 SEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRM-FSKQGVL 1236
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
TL IR+ P D G + C A N G A L V P
Sbjct: 1237 TLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVP 1273
Score = 46.4 bits (105), Expect = 0.001
Identities = 26/77 (33%), Positives = 37/77 (48%)
Query: 1117 KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY 1176
+V G+ A FE E + VRW + GS+I SN L +G + L + + D G Y
Sbjct: 20 EVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSY 79
Query: 1177 SCEVGNSKCTAILTVEE 1193
+ G+SK L V E
Sbjct: 80 AVIAGSSKVKFDLKVIE 96
Score = 44.8 bits (101), Expect = 0.003
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 4/101 (3%)
Query: 1192 EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKK 1250
E+ S F +L V LTVE+ D +V W K I+ + K+ S K
Sbjct: 359 EKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAK 418
Query: 1251 RTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
RTL I +C+ D Y CV+ K +T+L V+ PP ++
Sbjct: 419 RTLTISQCSLADDAAYQCVVGGEKCSTEL---FVKEPPVLI 456
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/92 (27%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 1013 KETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
K+ + F +K + EV A+ E E V W+R G I NKY G
Sbjct: 6 KKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISAS-NKYGLATEGTRH 64
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
L +R D+G Y+ I ++ V+E
Sbjct: 65 TLTVREVGPADQGSYAVIAGSSKVKFDLKVIE 96
Score = 40.3 bits (90), Expect = 0.074
Identities = 18/72 (25%), Positives = 34/72 (47%)
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
++ + G P P++ W+KNG L D + + +K+ + I++ Y A+N
Sbjct: 1199 MLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNL 1258
Query: 1651 AGTSSVEVTLKV 1662
G + E L+V
Sbjct: 1259 QGEARCECRLEV 1270
Score = 39.9 bits (89), Expect = 0.098
Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 4/96 (4%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSI 789
E P +PL + V G + +L V G+P+P I+W KN + S ++
Sbjct: 1179 EAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTL 1238
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
I KP D G+Y +A N +G A + V P
Sbjct: 1239 EIRKPCPF-DGGIYVCRATNLQGEARCECRLEVRVP 1273
Score = 37.9 bits (84), Expect = 0.39
Identities = 43/177 (24%), Positives = 72/177 (40%), Gaps = 22/177 (12%)
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV----AVNREGEASLP 722
WL G+E+VPD I V+ +H L I +V E Y+ V A N +
Sbjct: 577 WLKNGKELVPDSRIKVSHIGRVHK----LTIDDVTPADEADYSFVPEGFACNLSAKLHFM 632
Query: 723 IVLKIKTGEKEPPQVIEPL-----KSMIVRQGESVILSAQVVGNPRPTITWCK-----NN 772
V +EPP++ +++V G + L + G+P PT+ W K N
Sbjct: 633 EVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNK 692
Query: 773 KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
P + P + S + KK+ E ++ E + + ++ TVE +E+
Sbjct: 693 APARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETT----KDRSIFTVEGAEKED 745
Score = 36.3 bits (80), Expect = 1.2
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVY--TL 805
GE V L G PRP +TW K +P+ + T +I ++ + G Y T+
Sbjct: 988 GEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRVHSGTYQVTV 1047
Query: 806 KAENSEGIAETSAVITVEEPT 826
+ EN E A T + V++P+
Sbjct: 1048 RIENMEDKA-TLVLQVVDKPS 1067
>X69090-1|CAA48833.1| 1451|Homo sapiens 190kD protein protein.
Length = 1451
Score = 139 bits (337), Expect = 9e-32
Identities = 105/402 (26%), Positives = 170/402 (42%), Gaps = 18/402 (4%)
Query: 1669 PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVETYC 1727
P + + E +R V + WKPP G E Y +EK E W +V ++ +
Sbjct: 503 PPTDLSVTEATRSYVVLSWKPP-GQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFA 561
Query: 1728 IQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESVYI 1786
+ L E Y FRV N G E E+ E V+ LD+P D SV +
Sbjct: 562 LFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDT-SVVV 620
Query: 1787 TWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXARI--QKLSINTTYQFRIYARN 1843
+W E ++ Y +E G KW+ R L +Y FR+ A N
Sbjct: 621 SW--EESKDAKELVGYYIEANVAGSGKWEPCNNNPVKTHRFTCHGLVTGQSYIFRVRAVN 678
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
G S + I + + PPS P + ES S+ L W +P+ GG+ IT Y +
Sbjct: 679 AAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFRDSMVLGWKQPDKTGGAEITGYYVN 738
Query: 1904 FKT----VKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVR 1958
++ V GK W + + I N+KE F+++A N G+ P+ S+ +
Sbjct: 739 YREVIDGVPGK-WREANVKAVREEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFK 797
Query: 1959 LEKHA-TVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTK-TMWMEV 2016
E+ VP PP + L+ V + ++ W P G P+ GY + +++ K W +
Sbjct: 798 CEEWTIAVPGPPHS-LKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEKAKEDQWRGL 856
Query: 2017 GKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ + + +R L E +Y+ R+ A N+ G+ +P + P
Sbjct: 857 NEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAGP 898
Score = 124 bits (299), Expect = 4e-27
Identities = 114/498 (22%), Positives = 184/498 (36%), Gaps = 42/498 (8%)
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
PE+ WY+NG L K + + + L + YTI +
Sbjct: 303 PEIRWYRNGVPLSPSKWVQTLWSGERATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVF 362
Query: 1662 VYDKPSKPEG----PVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
V D ++ EG P+ ++ E +++ + I WK P DGG + Y I+K E + W +
Sbjct: 363 VRDADAEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQ 422
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGF------SEALESEPIVIKTALDVPSX 1769
D + + L E Y+FRV A N +G SEA+ + K L P
Sbjct: 423 CNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEAVAALDPAEKARLKSPLS 482
Query: 1770 XXXXXXXXXIDNES--------------------VYITWFPSEKNGGSPIIDYKVEIKQE 1809
+ S V ++W P + G I+ + + +
Sbjct: 483 TLDWTVIVTEEEPSEGIVPGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCEAG 542
Query: 1810 GKKWKXXXXXXXXXA---RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
+ W+ + + L+ +Y FR+ N G P + + +G L P
Sbjct: 543 TENWQRVNTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIP 602
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
P + S +T SV + W E S + Y IE W H
Sbjct: 603 KAPGKIIPSRNTDTSVVVSWEE--SKDAKELVGYYIEANVAGSGKWEPCNNNPVKTHRFT 660
Query: 1927 IENIKEKDEIIFRISAENTVGVS-LPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMT 1985
+ IFR+ A N G+S +S+++ ++ PSPP + ++V+
Sbjct: 661 CHGLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFRDSMVL- 719
Query: 1986 SWGTPEWDGGAPLLGYNIAIRDVTKTM---WMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
W P+ GGA + GY + R+V + W E V + I +L EN Y ++
Sbjct: 720 GWKQPDKTGGAEITGYYVNYREVIDGVPGKWREANVKAVREEAYKISNLKENMVYQFQVA 779
Query: 2043 ARNEIGLSEPLESDEPFK 2060
A N GL P E FK
Sbjct: 780 AMNMAGLGAPSAVSECFK 797
Score = 68.9 bits (161), Expect = 2e-10
Identities = 58/238 (24%), Positives = 94/238 (39%), Gaps = 13/238 (5%)
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTS-----SVEVTLKVYDKPSKPEGPVIMREISR 1680
KT L S + + A N AG S S + +K P P + E R
Sbjct: 655 KTHRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFR 714
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDN---NRWIKVADVDRDVETYCIQKLNENCEY 1737
+S+ + WK P GG E+T Y + E + +W + E Y I L EN Y
Sbjct: 715 DSMVLGWKQPDKTGGAEITGYYVNYREVIDGVPGKWREANVKAVREEAYKISNLKENMVY 774
Query: 1738 MFRVIAQNPVGF-SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGG 1796
F+V A N G + + SE + + +S+ + W P +G
Sbjct: 775 QFQVAAMNMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGR 834
Query: 1797 SPIIDYKVEIKQEGK--KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLP 1850
+P+ Y V++K++ K +W+ +++ L +Y FR+ A N+ G P
Sbjct: 835 TPVTGYFVDLKEKAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKP 892
Score = 67.7 bits (158), Expect = 4e-10
Identities = 73/313 (23%), Positives = 121/313 (38%), Gaps = 35/313 (11%)
Query: 1780 DNESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXAR--IQKLSINTTYQ 1836
+ + + I+W +GGSPI+ Y ++ + G W AR + L +Y
Sbjct: 386 NKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYI 445
Query: 1837 FRIYARNEIGTSLPYTSDDKI--------------------TIGKTLTPPSQ------PR 1870
FR+ A N++G P + + T+ T PS+ P
Sbjct: 446 FRVRAVNKMGIGFPSRVSEAVAALDPAEKARLKSPLSTLDWTVIVTEEEPSEGIVPGPPT 505
Query: 1871 NFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT-VGGSVHEHCIEN 1929
+ V+E+T V L W P G I Y +E ++W ++ T + + +
Sbjct: 506 DLSVTEATRSYVVLSWKPPGQRGHEGIM-YFVEKCEAGTENWQRVNTELPVKSPRFALFD 564
Query: 1930 IKEKDEIIFRISAENTVGVSLPTESQSVR-LEKHATVPSPPTAPLEIRMVGSNIVMTSWG 1988
+ E FR+ N+ GV P+E+ V + +P P + R +++V+ SW
Sbjct: 565 LAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVV-SW- 622
Query: 1989 TPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
E L+GY I W V T +F L +Y+ R+ A N G
Sbjct: 623 -EESKDAKELVGYYIEANVAGSGKWEPCNNNPVKTHRFTCHGLVTGQSYIFRVRAVNAAG 681
Query: 2049 LSEPLESDEPFKV 2061
LSE + E +V
Sbjct: 682 LSEYSQDSEAIEV 694
Score = 57.2 bits (132), Expect = 6e-07
Identities = 58/243 (23%), Positives = 99/243 (40%), Gaps = 25/243 (10%)
Query: 1284 VEFPPKI-VDYEREYR-IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
+ F K V + RE + G V + + + F QP W N + K + +
Sbjct: 269 IHFDDKFDVSFGREGETMSLGCRVVITPEIKHF-QPEIRWYRNGVPLSPSKWVQTLWSGE 327
Query: 1342 SASLTIKKVENTDAGIYKLRL------ENNCGHADV-EMNVTILDKPSPPGKPNILEIDS 1394
A+LT + D G+Y +R+ E + V + + I P+ P LE +
Sbjct: 328 RATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVKCLEANK 387
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFR 1452
I I W +P G S I+ Y ++ E+ T W + + + + L SY FR
Sbjct: 388 DYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFR 447
Query: 1453 AYAVNEVDISDASETTEYYKVI---KETKIQSP----------TVEKPLKNITTEPNEDI 1499
AVN++ I S +E + ++ +++SP T E+P + I P D+
Sbjct: 448 VRAVNKMGIGFPSRVSEAVAALDPAEKARLKSPLSTLDWTVIVTEEEPSEGIVPGPPTDL 507
Query: 1500 ELT 1502
+T
Sbjct: 508 SVT 510
Score = 53.2 bits (122), Expect = 1e-05
Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 6/114 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTT--EW--ISVKNITK 1435
PSPP LE S+ + W +P+ TG + I Y V Y+E ID +W +VK + +
Sbjct: 701 PSPPCDITCLESFRDSMVLGWKQPDKTGGAEITGYYVNYREVIDGVPGKWREANVKAVRE 760
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
I NLK N Y+F+ A+N + S +E +K +E I P LK
Sbjct: 761 EAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFK-CEEWTIAVPGPPHSLK 813
Score = 51.2 bits (117), Expect = 4e-05
Identities = 47/233 (20%), Positives = 86/233 (36%), Gaps = 14/233 (6%)
Query: 488 LNEKIDKLPVFEKPTSEEQSM-APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
L + +++ + +E+ + AP F+ K R + V+ C + G+P P++TW++
Sbjct: 118 LRKTLEETETYHAKLNEDHLLHAPEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKN 177
Query: 547 TAIIKPSQDFQMYYDDD--NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
I + Y + + TL I ED + A N G S+ ++V+
Sbjct: 178 QVPINVHANPGKYIIESRYGMHTLEINACDFEDTAQYRASAMNVKGELSAYASVVVKRYK 237
Query: 605 SDHGSEMTVXXXXXXXXXXXXA--DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ F K + EG + L CR+V PE
Sbjct: 238 GEFDETRFHAGASTMPLSFGVTPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPE 297
Query: 663 -----PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTV 710
P+I W G + P + + + + L +++ K EG YT+
Sbjct: 298 IKHFQPEIRWYRNGVPLSPSKWVQTLWSGER----ATLTFSHLNKEDEGLYTI 346
Score = 48.8 bits (111), Expect = 2e-04
Identities = 81/384 (21%), Positives = 149/384 (38%), Gaps = 30/384 (7%)
Query: 457 YVQKHLTEEKGWVPAQYLMD---ENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFV 513
+++K E++G Q L D N+ T L + +K+ K F++ + P FV
Sbjct: 1070 FMEKLQDEDEGTYTFQ-LQDGKATNHSTVVLVGDVFKKLQKEAEFQRQ-EWIRKQGPHFV 1127
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
E L + T + V +C+V + I W++ I + D + TL+I E
Sbjct: 1128 EYLSWEVTGE-CNVLLKCKVANIKKETHIVWYKDEREISVDEKHDF---KDGICTLLITE 1183
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEA---PLSDHGSEMTVXXXXXXXXXXXXADIL 629
+DAG + + K+ G S +L+ EA + + ++ + L
Sbjct: 1184 FSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELMMEVCKKIALSATDLKIQSTAEGIQL 1243
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+ + K + GS I R+ + WL E P N D
Sbjct: 1244 YSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGEQIWLQINE---PTPN-------DKG 1293
Query: 690 MYCSVLKITNVKKFQEGTYTVVA-VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VR 747
Y V+++ + K + T + E A + + EK +V+ L ++ ++
Sbjct: 1294 KY--VMELFDGKTGHQKTVDLSGQAYDEAYAEFQRLKQAAIAEKNRARVLGGLPDVVTIQ 1351
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYT 804
+G+++ L+ V G+P P ++W KN K + K + + + D G Y
Sbjct: 1352 EGKALNLTCNVWGDPPPEVSWLKNEKALAQTDHCNLKFEAGRTAYFTINGVSTADSGKYG 1411
Query: 805 LKAENSEGIAETSAVITVEEPTEE 828
L +N G + ++V P EE
Sbjct: 1412 LVVKNKYGSETSDFTVSVFIPEEE 1435
Score = 44.8 bits (101), Expect = 0.003
Identities = 55/207 (26%), Positives = 85/207 (41%), Gaps = 39/207 (18%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTK----SDGDTH 787
P +I+P +S V + E+V L + G P P +TW KN P+ A P K S H
Sbjct: 141 PEFIIKP-RSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH 199
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-----------------PTEENA 830
++ I +D Y A N +G A + V+ P
Sbjct: 200 TLEI-NACDFEDTAQYRASAMNVKGELSAYASVVVKRYKGEFDETRFHAGASTMPLSFGV 258
Query: 831 EPPLFINRFQ-------EITVKEKG-TIKLVARVTRNPV-----PSITWYRNNEIISPSE 877
P + +RF+ +++ +G T+ L RV P P I WYRN +SPS+
Sbjct: 259 TPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPEIKHFQPEIRWYRNGVPLSPSK 318
Query: 878 TITQNFDGENIELVITNVDSEIDSGDY 904
+ + GE L ++++ E D G Y
Sbjct: 319 WVQTLWSGERATLTFSHLNKE-DEGLY 344
Score = 44.0 bits (99), Expect = 0.006
Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 5/117 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP ++ E S + + W P G+ I+Y+ VE E T W V + +
Sbjct: 501 PGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYF-VEKCEAGTENWQRVNTELPVKSPR 559
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI-QSPTVEKPLKNITT 1493
++ +L SY FR N + + SE TE V + I ++P P +N T
Sbjct: 560 FALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDT 616
Score = 43.2 bits (97), Expect = 0.010
Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 20/213 (9%)
Query: 996 VIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS--ETADVVWERDG 1053
V K + K+ E +++ P F+ L +EV + +L+ ++ + + +VW +D
Sbjct: 1103 VFKKLQKEAEFQRQEWIRKQGPHFVEYLS-WEVTGECNVLLKCKVANIKKETHIVWYKDE 1161
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE--SCTAEVTVV-----ELP 1106
I + K+DF K G I L I S D G Y IL+D+ + + +V EL
Sbjct: 1162 REISVDE-KHDF-KDG-ICTLLITEFSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELM 1218
Query: 1107 PEII-------TRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGK 1159
E+ T L+ Q +G + + D V W +GS I++S+ ++ + G+
Sbjct: 1219 MEVCKKIALSATDLKIQSTAEGIQLYSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGE 1278
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
+ L+I + +D G+Y E+ + K TV+
Sbjct: 1279 QIWLQINEPTPNDKGKYVMELFDGKTGHQKTVD 1311
Score = 42.3 bits (95), Expect = 0.018
Identities = 31/141 (21%), Positives = 60/141 (42%), Gaps = 9/141 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKN--ITKTQ 1437
P PP E+ S+ + W P ++G + + Y V+ +E +W + I
Sbjct: 806 PGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEKAKEDQWRGLNEAAIKNVY 865
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNE 1497
++ LK SY FR A+N+ + S+ V+ ET+ P ++ + N+ +
Sbjct: 866 LKVRGLKEGVSYVFRVRAINQAGVGKPSDLAG--PVVAETR---PGRKEVVVNVDDDGVI 920
Query: 1498 DIELTCIFGGVPQPKVTWYRD 1518
+ C P+ + +W +D
Sbjct: 921 SLNFEC-DKMTPKSEFSWSKD 940
Score = 41.5 bits (93), Expect = 0.032
Identities = 19/82 (23%), Positives = 36/82 (43%)
Query: 842 ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDS 901
+T++E + L V +P P ++W +N + ++ ++ F+ N S DS
Sbjct: 1348 VTIQEGKALNLTCNVWGDPPPEVSWLKNEKALAQTDHCNLKFEAGRTAYFTINGVSTADS 1407
Query: 902 GDYKCVASNSAGKSSHGARVTI 923
G Y V N G + V++
Sbjct: 1408 GKYGLVVKNKYGSETSDFTVSV 1429
Score = 40.7 bits (91), Expect = 0.056
Identities = 31/124 (25%), Positives = 56/124 (45%), Gaps = 10/124 (8%)
Query: 1358 YKLRLENNCGHADVE--MNVTI----LDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+++R N+ G + VT+ LD P PGK +S+ + W+E ++
Sbjct: 573 FRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDA--KE 630
Query: 1412 IIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
++ Y +E + +W N + + + L T SY FR AVN +S+ S+ +E
Sbjct: 631 LVGYYIEANVAGSGKWEPCNNNPVKTHRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSE 690
Query: 1470 YYKV 1473
+V
Sbjct: 691 AIEV 694
Score = 40.3 bits (90), Expect = 0.074
Identities = 33/102 (32%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN----NEIISPSETITQNFDGENI 888
P FI + + TV EK +KL + P P +TWY+N N +P + I ++ G +
Sbjct: 141 PEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH- 199
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
L I D E D+ Y+ A N G+ S A V + K F
Sbjct: 200 TLEINACDFE-DTAQYRASAMNVKGELSAYASVVVKRYKGEF 240
Score = 40.3 bits (90), Expect = 0.074
Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNT 1650
+T + G PPPEV W KN L N+ + +T+ I + + S KY + N
Sbjct: 1358 LTCNVWGDPPPEVSWLKNEKALAQTDHCNLKFEAGRTAYFTINGVSTADSGKYGLVVKNK 1417
Query: 1651 AGTSSVEVTLKVY 1663
G+ + + T+ V+
Sbjct: 1418 YGSETSDFTVSVF 1430
Score = 39.5 bits (88), Expect = 0.13
Identities = 20/89 (22%), Positives = 38/89 (42%), Gaps = 2/89 (2%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G + C V G P P+++W + + + + ++ A I V D+G +
Sbjct: 1352 EGKALNLTCNVWGDPPPEVSWLKNEKALAQTDHCNLKFEAGRTAYFTINGVSTADSGKYG 1411
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEM 611
V KN G S T++ V + + + M
Sbjct: 1412 LVVKNKYG--SETSDFTVSVFIPEEEARM 1438
Score = 39.1 bits (87), Expect = 0.17
Identities = 64/280 (22%), Positives = 115/280 (41%), Gaps = 40/280 (14%)
Query: 1126 FEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSK- 1184
FE + + W KD + S +++ G K K+ D +DD G YSC+V ++
Sbjct: 924 FECDKMTPKSEFSWSKDYVSTEDSPRLEVESKGNKTKMTFKDLGMDDLGIYSCDVTDTDG 983
Query: 1185 CTAILTVEEPSINFTLRLP---EFILVPANTDAYLTVEIPDETLDVTW------------ 1229
+ ++E + L L +F VP ++ L VEI ++ W
Sbjct: 984 IASSYLIDEEELKRLLALSHEHKFPTVPVKSE--LAVEILEKGQVRFWMQAEKLSGNAKV 1041
Query: 1230 ---YKKKSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK----STTKLKV 1281
+ +K + E + K + + + + K ++D+ YT L D K ST L
Sbjct: 1042 NYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQLQDGKATNHSTVVLVG 1101
Query: 1282 EVVEFPPKIVDYER-EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH------- 1333
+V + K +++R E+ K+G + ++ + N IKK H
Sbjct: 1102 DVFKKLQKEAEFQRQEWIRKQGPHFVEYLSWEVTGECNVLLKCKVANIKKETHIVWYKDE 1161
Query: 1334 TKPSIDSKS------ASLTIKKVENTDAGIYKLRLENNCG 1367
+ S+D K +L I + DAGIY++ L+++ G
Sbjct: 1162 REISVDEKHDFKDGICTLLITEFSKKDAGIYEVILKDDRG 1201
Score = 38.3 bits (85), Expect = 0.30
Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 9/90 (10%)
Query: 747 RQGESVILSAQVVGNP-----RPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVK 798
R+GE++ L +VV P +P I W +N P+ K + T G+ ++T K +
Sbjct: 281 REGETMSLGCRVVITPEIKHFQPEIRWYRNGVPLSPSKWVQTLWSGERATLTFSHLNK-E 339
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEE 828
DEG+YT++ E + SA + V + E
Sbjct: 340 DEGLYTIRVRMGEYYEQYSAYVFVRDADAE 369
Score = 37.5 bits (83), Expect = 0.52
Identities = 20/80 (25%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS-KSASLTIKKVENTDAGI 1357
I+ G + L + P P W+ N K + + H ++ ++A TI V D+G
Sbjct: 1350 IQEGKALNLTCNVWGDPPPEVSWLKNEKALAQTDHCNLKFEAGRTAYFTINGVSTADSGK 1409
Query: 1358 YKLRLENNCGHADVEMNVTI 1377
Y L ++N G + V++
Sbjct: 1410 YGLVVKNKYGSETSDFTVSV 1429
Score = 36.7 bits (81), Expect = 0.91
Identities = 23/104 (22%), Positives = 43/104 (41%), Gaps = 4/104 (3%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P + EG + L C + P P+++WL + + ++ ++ E+ Y I
Sbjct: 1345 PDVVTIQEGKALNLTCNVWGDPPPEVSWLKNEKALAQTDHCNLKFEAGRTAY---FTING 1401
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ-VIEPLK 742
V G Y +V N+ G + + + E+E +E LK
Sbjct: 1402 VSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEEARMAALESLK 1445
Score = 35.9 bits (79), Expect = 1.6
Identities = 24/93 (25%), Positives = 45/93 (48%), Gaps = 8/93 (8%)
Query: 1433 ITKTQTSIQNLKTNSSYRFRAYAVN----EVDISDASETTEYY--KVIKETKIQSPT-VE 1485
++K TS + S + R + + + E TE Y K+ ++ + +P +
Sbjct: 86 VSKQATSALQQEETSEKKSRKVVIRGKAERLSLRKTLEETETYHAKLNEDHLLHAPEFII 145
Query: 1486 KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
KP + E E+++L C G P+P+VTWY++
Sbjct: 146 KPRSHTVWE-KENVKLHCSIAGWPEPRVTWYKN 177
Score = 34.3 bits (75), Expect = 4.9
Identities = 32/102 (31%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI-SVAIESDMHMYC 692
P F KP++ V E ++ L C + PEP + W I N IES M+
Sbjct: 141 PEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH- 199
Query: 693 SVLKITNVKKFQE-GTYTVVAVNREGEAS--LPIVLKIKTGE 731
L+I N F++ Y A+N +GE S +V+K GE
Sbjct: 200 -TLEI-NACDFEDTAQYRASAMNVKGELSAYASVVVKRYKGE 239
>U91629-1|AAC04620.1| 1274|Homo sapiens cardiac myosin binding
protein-C protein.
Length = 1274
Score = 139 bits (336), Expect = 1e-31
Identities = 114/462 (24%), Positives = 200/462 (43%), Gaps = 28/462 (6%)
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASL-TIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+DEW+ + K++ + + +K S+ T++ E D G+Y + ++N G V + V
Sbjct: 708 SDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVK 767
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--IT 1434
++D P P P I + S + W+ P G I+ Y++E ++ + W+ + I
Sbjct: 768 VIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQ 827
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI----KETKIQSPTVEKPLKN 1490
+ + + Y R YAVN + +S S ++ + I + T + V +
Sbjct: 828 ELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTVS 887
Query: 1491 ITTEPNEDIELTCIFGGVPQPKVTWYRDG-KKLKTAKATYENRXXXXXXXXXXXXXXXYK 1549
+ P E + GG+ V + +G + A ++
Sbjct: 888 LKWRPPERVGA----GGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFR 943
Query: 1550 CIAFNDHGE---VETSCVVGIQ---QKPVITISNEDIKQ--KHKVGDEWLVTAVIEGIPP 1601
A N G V T+ V +Q Q+P + + ++Q + KVG+ + +G P
Sbjct: 944 VRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRH-LRQTIQKKVGEPVNLLIPFQGKPR 1002
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P+V W K G L + E +I +++ I+ +R HS Y + + L+
Sbjct: 1003 PQVTWTKEGQPLAGE-EVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQ 1061
Query: 1662 VYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
V DKPS P+ + + + +V +EWKPP D G EL Y ++K + W V + R
Sbjct: 1062 VVDKPSPPQ-DLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYR 1120
Query: 1722 DVETYC-IQKLNENCEYMFRVIAQNPVGFSE--ALESEPIVI 1760
T+C + +L Y FRV +QN VGFS+ A EP+ I
Sbjct: 1121 --RTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFI 1160
Score = 116 bits (279), Expect = 9e-25
Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 10/257 (3%)
Query: 1019 FIRKLQD-FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
F +KL+ ++V + L VE+ A+V W ++G+ I+ +KY FE G R L I
Sbjct: 365 FQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTIS 424
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR-LQNQKVNKGNKATFEIELTKGDAL 1136
S+ D+ Y C++ E C+ E+ V E PP +ITR L++Q V G + FE E+++ A
Sbjct: 425 QCSLADDAAYQCVVGGEKCSTELFVKE-PPVLITRPLEDQLVMVGQRVEFECEVSEEGAQ 483
Query: 1137 VRWFKDGSEIQFSNHIQLTI--DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEP 1194
V+W KDG E+ + DG++ L I + L+DAG Y+ + A L V+E
Sbjct: 484 VKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEK 543
Query: 1195 SINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK-KSVIEDTE-KFTLISDVKKRT 1252
+ + + ++V A A E+ DE + W K K ++ D+ K + I V K
Sbjct: 544 KLEVYQSIAD-LMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHK-- 600
Query: 1253 LIIRKCTEDDQCEYTCV 1269
L I T D+ +Y+ V
Sbjct: 601 LTIDDVTPADEADYSFV 617
Score = 112 bits (269), Expect = 2e-23
Identities = 109/468 (23%), Positives = 195/468 (41%), Gaps = 38/468 (8%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
E + + T + S+ ++ ++ YT+ N G V +T+KV D P P P
Sbjct: 720 ETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPK 779
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVETYCIQKLN 1732
I + +S T++W+PP DGG + Y +E+ + + RW+++ D+ +++ ++ +++
Sbjct: 780 ISN-VGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQEL-SHEARRMI 837
Query: 1733 ENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPS 1791
E Y RV A N +G S + S+P + + PS + + +V + W P
Sbjct: 838 EGVVYEMRVYAVNAIGMSRPSPASQPFM---PIGPPS-EPTHLAVEDVSDTTVSLKWRPP 893
Query: 1792 EKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARI--QKLSINTTYQFRIYARNEIGTS 1848
E+ G + Y VE EG +W I + L FR+ A N G
Sbjct: 894 ERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPG 953
Query: 1849 LPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEF--KT 1906
P T+ + +T+ + L P + ++ + V G P+ N +I F K
Sbjct: 954 APVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKV-----------GEPV-NLLIPFQGKP 1001
Query: 1907 VKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISA----ENTVGVSLPTESQSVRLEK 1961
+WTK + G E I N D I+F +A T V++ E+ +
Sbjct: 1002 RPQVTWTKEGQPLAG--EEVSIRN-SPTDTILFIRAARRVHSGTYQVTVRIENMEDKATL 1058
Query: 1962 HATVPSPPTAPLEIRMV---GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
V P+ P ++R+ G N+ + W P+ G L GY + D W V +
Sbjct: 1059 VLQVVDKPSPPQDLRVTDAWGLNVAL-EWKPPQDVGNTELWGYTVQKADKKTMEWFTVLE 1117
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEG 2066
+ +L + Y R++++N +G S+ + + IP G
Sbjct: 1118 -HYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPRPG 1164
Score = 100 bits (240), Expect = 5e-20
Identities = 78/284 (27%), Positives = 123/284 (43%), Gaps = 6/284 (2%)
Query: 924 DVEKVT-FVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQE-GR 980
D +K T F K L+ +Y+ +G + L + + H KW N +EI + I + G
Sbjct: 358 DEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGA 417
Query: 981 XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D +C+V ++ ST L VKE R L+D V E E+
Sbjct: 418 KRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEV 477
Query: 1041 NSETADVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
+ E A V W +DG E+ + + KY F+K G L I + D G Y+ AE
Sbjct: 478 SEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAE 537
Query: 1100 VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGK 1159
+ V E E+ + + V ++A F+ E++ + W K+G E+ + I+++ G+
Sbjct: 538 LIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGR 597
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKC--TAILTVEEPSINFTLR 1201
KL I D D +YS C +A L E I+F R
Sbjct: 598 VHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPR 641
Score = 83.4 bits (197), Expect = 8e-15
Identities = 60/239 (25%), Positives = 106/239 (44%), Gaps = 19/239 (7%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
K G V LL+ +Q P+P W + + + L I+ +G Y+
Sbjct: 986 KVGEPVNLLIPFQGKPRPQVTWTKEGQPLAG-EEVSIRNSPTDTILFIRAARRVHSGTYQ 1044
Query: 1360 L--RLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
+ R+EN A + + V +DKPSPP + + ++ + W P++ GN+ + Y V
Sbjct: 1045 VTVRIENMEDKATLVLQV--VDKPSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTV 1102
Query: 1418 EYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ + T EW +V ++ +T + L + Y FR ++ N V SD + TT+ I
Sbjct: 1103 QKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPR 1162
Query: 1477 TKI-------------QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
I ++P+ +PL N + L C G P+PK++W+++G L
Sbjct: 1163 PGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDL 1221
Score = 79.8 bits (188), Expect = 1e-13
Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 8/155 (5%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTS 1986
+E +++DE ++ ++ +N VG E Q K VP P AP +I VG +
Sbjct: 738 VEGAEKEDEGVYTVTVKNPVG-----EDQVNLTVKVIDVPDAPAAP-KISNVGEDSCTVQ 791
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P +DGG P+LGY + + WM + + L R + E Y +R+YA N
Sbjct: 792 WEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMIEGVVYEMRVYAVNA 851
Query: 2047 IGLSEPLESDEPFKVI--PGEGSHADEEPGEQTEV 2079
IG+S P + +PF I P E +H E T V
Sbjct: 852 IGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTV 886
Score = 56.4 bits (130), Expect = 1e-06
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 1/97 (1%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F + L + G T C V G P+P+I+WF+ + F+M + V
Sbjct: 1178 SEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRM-FSKQGVL 1236
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
TL IR+ P D G + C A N G A L V P
Sbjct: 1237 TLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVP 1273
Score = 46.4 bits (105), Expect = 0.001
Identities = 26/77 (33%), Positives = 37/77 (48%)
Query: 1117 KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY 1176
+V G+ A FE E + VRW + GS+I SN L +G + L + + D G Y
Sbjct: 20 EVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSY 79
Query: 1177 SCEVGNSKCTAILTVEE 1193
+ G+SK L V E
Sbjct: 80 AVIAGSSKVKFDLKVIE 96
Score = 44.8 bits (101), Expect = 0.003
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 4/101 (3%)
Query: 1192 EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDT-EKFTLISDVKK 1250
E+ S F +L V LTVE+ D +V W K I+ + K+ S K
Sbjct: 359 EKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAK 418
Query: 1251 RTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
RTL I +C+ D Y CV+ K +T+L V+ PP ++
Sbjct: 419 RTLTISQCSLADDAAYQCVVGGEKCSTEL---FVKEPPVLI 456
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/92 (27%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 1013 KETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
K+ + F +K + EV A+ E E V W+R G I NKY G
Sbjct: 6 KKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISAS-NKYGLATEGTRH 64
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
L +R D+G Y+ I ++ V+E
Sbjct: 65 TLTVREVGPADQGSYAVIAGSSKVKFDLKVIE 96
Score = 40.3 bits (90), Expect = 0.074
Identities = 18/72 (25%), Positives = 34/72 (47%)
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
++ + G P P++ W+KNG L D + + +K+ + I++ Y A+N
Sbjct: 1199 MLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNL 1258
Query: 1651 AGTSSVEVTLKV 1662
G + E L+V
Sbjct: 1259 QGEARCECRLEV 1270
Score = 39.9 bits (89), Expect = 0.098
Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 4/96 (4%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSI 789
E P +PL + V G + +L V G+P+P I+W KN + S ++
Sbjct: 1179 EAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTL 1238
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
I KP D G+Y +A N +G A + V P
Sbjct: 1239 EIRKPCPF-DGGIYVCRATNLQGEARCECRLEVRVP 1273
Score = 37.9 bits (84), Expect = 0.39
Identities = 43/177 (24%), Positives = 72/177 (40%), Gaps = 22/177 (12%)
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV----AVNREGEASLP 722
WL G+E+VPD I V+ +H L I +V E Y+ V A N +
Sbjct: 577 WLKNGKELVPDSRIKVSHIGRVHK----LTIDDVTPADEADYSFVPEGFACNLSAKLHFM 632
Query: 723 IVLKIKTGEKEPPQVIEPL-----KSMIVRQGESVILSAQVVGNPRPTITWCK-----NN 772
V +EPP++ +++V G + L + G+P PT+ W K N
Sbjct: 633 EVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNK 692
Query: 773 KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
P + P + S + KK+ E ++ E + + ++ TVE +E+
Sbjct: 693 APARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETT----KDRSIFTVEGAEKED 745
Score = 36.3 bits (80), Expect = 1.2
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVY--TL 805
GE V L G PRP +TW K +P+ + T +I ++ + G Y T+
Sbjct: 988 GEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRVHSGTYQVTV 1047
Query: 806 KAENSEGIAETSAVITVEEPT 826
+ EN E A T + V++P+
Sbjct: 1048 RIENMEDKA-TLVLQVVDKPS 1067
>BC116183-1|AAI16184.1| 1589|Homo sapiens myomesin 1, 185kDa protein.
Length = 1589
Score = 139 bits (336), Expect = 1e-31
Identities = 105/403 (26%), Positives = 172/403 (42%), Gaps = 19/403 (4%)
Query: 1669 PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVETYC 1727
P + + E +R V + WKPP G E Y +EK E W +V ++ +
Sbjct: 640 PPTDLSVTEATRSYVVLSWKPP-GQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFA 698
Query: 1728 IQKLNENCEYMFRVIAQNPVGFSEALES-EPIVIKTALDVPSXXXXXXXXXXIDNESVYI 1786
+ L E Y FRV N G E E+ E V+ LD+P D SV +
Sbjct: 699 LFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDT-SVVV 757
Query: 1787 TWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXARI--QKLSINTTYQFRIYARN 1843
+W E ++ Y +E G KW+ +R L +Y FR+ A N
Sbjct: 758 SW--EESKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVN 815
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
G S + I + + PPS P + ES S+ L W +P+ GG+ IT Y +
Sbjct: 816 AAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFRDSMVLGWKQPDKIGGAEITGYYVN 875
Query: 1904 FKT----VKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVR 1958
++ V GK W + S + I N+KE F+++A N G+ P+ S+ +
Sbjct: 876 YREVIDGVPGK-WREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFK 934
Query: 1959 LEKHA-TVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRD--VTKTMWME 2015
E+ VP PP + L+ V + ++ W P G P+ GY + +++ + W
Sbjct: 935 CEEWTIAVPGPPHS-LKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRG 993
Query: 2016 VGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ + + + +R L E +Y+ R+ A N+ G+ +P + P
Sbjct: 994 LNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAGP 1036
Score = 88.2 bits (209), Expect = 3e-16
Identities = 66/284 (23%), Positives = 110/284 (38%), Gaps = 10/284 (3%)
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXA---RIQKLSINTTYQFRIY 1840
V ++W P + G I+ + + + + W+ + + L+ +Y FR+
Sbjct: 654 VVLSWKPPGQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGKSYCFRVR 713
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
N G P + + +G L P P + S +T SV + W E S + Y
Sbjct: 714 CSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEE--SKDAKELVGY 771
Query: 1901 IIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVS-LPTESQSVRL 1959
IE W + IFR+ A N G+S +S+++ +
Sbjct: 772 YIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEV 831
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM---WMEV 2016
+ PSPP + ++V+ W P+ GGA + GY + R+V + W E
Sbjct: 832 KAAIAPPSPPCDITCLESFRDSMVL-GWKQPDKIGGAEITGYYVNYREVIDGVPGKWREA 890
Query: 2017 GKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
V+ + I +L EN Y ++ A N GL P E FK
Sbjct: 891 NVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFK 934
Score = 65.3 bits (152), Expect = 2e-09
Identities = 54/222 (24%), Positives = 88/222 (39%), Gaps = 14/222 (6%)
Query: 1643 YTIEASNTAGTS-----SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLE 1697
+ + A N AG S S + +K P P + E R+S+ + WK P GG E
Sbjct: 809 FRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFRDSMVLGWKQPDKIGGAE 868
Query: 1698 LTKYAIEKHEPDN---NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGF-SEAL 1753
+T Y + E + +W + E Y I L EN Y F+V A N G + +
Sbjct: 869 ITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSA 928
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK- 1812
SE + + +S+ + W P +G +P+ Y V++K+ K
Sbjct: 929 VSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKE 988
Query: 1813 --WKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLP 1850
W+ +++ L +Y FR+ A N+ G P
Sbjct: 989 DQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKP 1030
Score = 64.1 bits (149), Expect = 5e-09
Identities = 34/114 (29%), Positives = 56/114 (49%), Gaps = 3/114 (2%)
Query: 1963 ATVPSPPTAPLEIRMVGSN--IVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD 2020
A + P APL+++ + +N ++ SW P DGG+P+LGY I +V W +
Sbjct: 504 AEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTP 563
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVI-PGEGSHADEEP 2073
V +F + L E +Y+ R+ A N++G+ P EP + P E + P
Sbjct: 564 VKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVFEPVAALDPAEKARLKGRP 617
Score = 61.7 bits (143), Expect = 3e-08
Identities = 49/198 (24%), Positives = 79/198 (39%), Gaps = 6/198 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT-VGGSVHE 1924
P P + V+E+T V L W P G I Y +E ++W ++ T +
Sbjct: 638 PGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIM-YFVEKCEAGTENWQRVNTELPVKSPR 696
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTESQSVR-LEKHATVPSPPTAPLEIRMVGSNIV 1983
+ ++ E FR+ N+ GV P+E+ V + +P P + R +++V
Sbjct: 697 FALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVV 756
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
+ SW E L+GY I W V +F L +Y+ R+ A
Sbjct: 757 V-SW--EESKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRA 813
Query: 2044 RNEIGLSEPLESDEPFKV 2061
N GLSE + E +V
Sbjct: 814 VNAAGLSEYSQDSEAIEV 831
Score = 60.5 bits (140), Expect = 6e-08
Identities = 55/239 (23%), Positives = 95/239 (39%), Gaps = 33/239 (13%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P+ P + E+ + + W +P +GGSPI Y I+ V SW++
Sbjct: 510 PAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARF 569
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTE----------SQSVRLE--------------- 1960
+ + E IFR+ A N +G+ P+ ++ RL+
Sbjct: 570 PVTGLIEGRSYIFRVRAVNKMGIGFPSRVFEPVAALDPAEKARLKGRPSAPWTGQIIVTE 629
Query: 1961 ---KHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
VP PPT L + + V+ SW P G ++ Y + + W V
Sbjct: 630 EEPSEGIVPGPPT-DLSVTEATRSYVVLSWKPPGQRGHEGIM-YFVEKCEAGTENWQRVN 687
Query: 2018 -KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
++ V + +F + DL+E +Y R+ N G+ EP E+ E + G+ + PG+
Sbjct: 688 TELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATE--VTVVGDKLDIPKAPGK 744
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/153 (26%), Positives = 64/153 (41%), Gaps = 6/153 (3%)
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
PE+ WY+NG L K + + + L + YTI +
Sbjct: 439 PEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVF 498
Query: 1662 VYDKPSKPEG----PVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
V D ++ EG P+ ++ E +++ + I WK P DGG + Y I+K E + W +
Sbjct: 499 VRDADAEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQ 558
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVG 1748
D + + L E Y+FRV A N +G
Sbjct: 559 CNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMG 591
Score = 54.4 bits (125), Expect = 4e-06
Identities = 49/197 (24%), Positives = 80/197 (40%), Gaps = 12/197 (6%)
Query: 1284 VEFPPKI-VDYEREYR-IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
+ F K V + RE + G V + + + F QP +W N + K + +
Sbjct: 405 IHFDDKFDVSFGREGETMSLGCRVVITPEIKHF-QPEIQWYRNGVPLSPSKWVQTLWSGE 463
Query: 1342 SASLTIKKVENTDAGIYKLRL------ENNCGHADV-EMNVTILDKPSPPGKPNILEIDS 1394
A+LT + D G+Y +R+ E + V + + I P+ P LE +
Sbjct: 464 RATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVKCLEANK 523
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFR 1452
I I W +P G S I+ Y ++ E+ T W + + + + L SY FR
Sbjct: 524 DYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFR 583
Query: 1453 AYAVNEVDISDASETTE 1469
AVN++ I S E
Sbjct: 584 VRAVNKMGIGFPSRVFE 600
Score = 52.0 bits (119), Expect = 2e-05
Identities = 43/160 (26%), Positives = 72/160 (45%), Gaps = 12/160 (7%)
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD------KPSPPGKPNILEIDS 1394
K + T + + I+++R N G ++ + ++ PSPP LE
Sbjct: 792 KGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIAPPSPPCDITCLESFR 851
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQE-IDTT--EW--ISVKNITKTQTSIQNLKTNSSY 1449
S+ + W +P+ G + I Y V Y+E ID +W +VK +++ I NLK N Y
Sbjct: 852 DSMVLGWKQPDKIGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVY 911
Query: 1450 RFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
+F+ A+N + S +E +K +E I P LK
Sbjct: 912 QFQVAAMNMAGLGAPSAVSECFK-CEEWTIAVPGPPHSLK 950
Score = 51.2 bits (117), Expect = 4e-05
Identities = 47/233 (20%), Positives = 86/233 (36%), Gaps = 14/233 (6%)
Query: 488 LNEKIDKLPVFEKPTSEEQSM-APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
L + +++ + +E+ + AP F+ K R + V+ C + G+P P++TW++
Sbjct: 254 LRKTLEETETYHAKLNEDHLLHAPEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKN 313
Query: 547 TAIIKPSQDFQMYYDDD--NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
I + Y + + TL I ED + A N G S+ ++V+
Sbjct: 314 QVPINVHANPGKYIIESRYGMHTLEINACDFEDTAQYRASAMNVKGELSAYASVVVKRYK 373
Query: 605 SDHGSEMTVXXXXXXXXXXXXA--DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ F K + EG + L CR+V PE
Sbjct: 374 GEFDETRFHAGASTMPLSFGVTPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPE 433
Query: 663 -----PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTV 710
P+I W G + P + + + + L +++ K EG YT+
Sbjct: 434 IKHFQPEIQWYRNGVPLSPSKWVQTLWSGER----ATLTFSHLNKEDEGLYTI 482
Score = 49.2 bits (112), Expect = 2e-04
Identities = 81/384 (21%), Positives = 150/384 (39%), Gaps = 30/384 (7%)
Query: 457 YVQKHLTEEKGWVPAQYLMD---ENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFV 513
+++K E++G Q L D N+ T L + +K+ K F++ + P FV
Sbjct: 1208 FMEKLQDEDEGTYTFQ-LQDGKATNHSTVVLVGDVFKKLQKEAEFQRQ-EWIRKQGPHFV 1265
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
E L + T + V +C+V + I W++ I + D + TL+I E
Sbjct: 1266 EYLSWEVTGE-CNVLLKCKVANIKKETHIVWYKDEREISVDEKHDF---KDGICTLLITE 1321
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEA---PLSDHGSEMTVXXXXXXXXXXXXADIL 629
+DAG + + K+ G S +L+ EA + + ++ + L
Sbjct: 1322 FSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELMMEVCKKIALSATDLKIQSTAEGIQL 1381
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+ + K + GS I R+ + WL E P N D
Sbjct: 1382 YSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGEQIWLQINE---PTPN-------DKG 1431
Query: 690 MYCSVLKITNVKKFQEGTYTVVA-VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VR 747
Y V+++ + K + T + E A + + EK +V+ L ++ ++
Sbjct: 1432 KY--VMELFDGKTGHQKTVDLSGQAYDEAYAEFQRLKQAAIAEKNRARVLGGLPDVVTIQ 1489
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYT 804
+G+++ L+ V G+P P ++W KN K + + K + + + D G Y
Sbjct: 1490 EGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGKYG 1549
Query: 805 LKAENSEGIAETSAVITVEEPTEE 828
L +N G + ++V P EE
Sbjct: 1550 LVVKNKYGSETSDFTVSVFIPEEE 1573
Score = 44.8 bits (101), Expect = 0.003
Identities = 55/207 (26%), Positives = 85/207 (41%), Gaps = 39/207 (18%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTK----SDGDTH 787
P +I+P +S V + E+V L + G P P +TW KN P+ A P K S H
Sbjct: 277 PEFIIKP-RSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH 335
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-----------------PTEENA 830
++ I +D Y A N +G A + V+ P
Sbjct: 336 TLEI-NACDFEDTAQYRASAMNVKGELSAYASVVVKRYKGEFDETRFHAGASTMPLSFGV 394
Query: 831 EPPLFINRFQ-------EITVKEKG-TIKLVARVTRNPV-----PSITWYRNNEIISPSE 877
P + +RF+ +++ +G T+ L RV P P I WYRN +SPS+
Sbjct: 395 TPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPEIKHFQPEIQWYRNGVPLSPSK 454
Query: 878 TITQNFDGENIELVITNVDSEIDSGDY 904
+ + GE L ++++ E D G Y
Sbjct: 455 WVQTLWSGERATLTFSHLNKE-DEGLY 480
Score = 44.4 bits (100), Expect = 0.005
Identities = 32/142 (22%), Positives = 60/142 (42%), Gaps = 10/142 (7%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISVKN--ITKT 1436
P PP E+ S+ + W P ++G + + Y V+ +E E W + I
Sbjct: 943 PGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNV 1002
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
++ LK SY FR A+N+ + S+ V+ ET+ P ++ + N+ +
Sbjct: 1003 YLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAG--PVVAETR---PGTKEVVVNVDDDGV 1057
Query: 1497 EDIELTCIFGGVPQPKVTWYRD 1518
+ C P+ + +W +D
Sbjct: 1058 ISLNFEC-DKMTPKSEFSWSKD 1078
Score = 44.0 bits (99), Expect = 0.006
Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 5/117 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP ++ E S + + W P G+ I+Y+ VE E T W V + +
Sbjct: 638 PGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYF-VEKCEAGTENWQRVNTELPVKSPR 696
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI-QSPTVEKPLKNITT 1493
++ +L SY FR N + + SE TE V + I ++P P +N T
Sbjct: 697 FALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDT 753
Score = 43.6 bits (98), Expect = 0.008
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNT 1650
+T + G PPPEV W KN L +D N+ + +T+ I + + S KY + N
Sbjct: 1496 LTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGKYGLVVKNK 1555
Query: 1651 AGTSSVEVTLKVY 1663
G+ + + T+ V+
Sbjct: 1556 YGSETSDFTVSVF 1568
Score = 43.2 bits (97), Expect = 0.010
Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 20/213 (9%)
Query: 996 VIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS--ETADVVWERDG 1053
V K + K+ E +++ P F+ L +EV + +L+ ++ + + +VW +D
Sbjct: 1241 VFKKLQKEAEFQRQEWIRKQGPHFVEYLS-WEVTGECNVLLKCKVANIKKETHIVWYKDE 1299
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE--SCTAEVTVV-----ELP 1106
I + K+DF K G I L I S D G Y IL+D+ + + +V EL
Sbjct: 1300 REISVDE-KHDF-KDG-ICTLLITEFSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELM 1356
Query: 1107 PEII-------TRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGK 1159
E+ T L+ Q +G + + D V W +GS I++S+ ++ + G+
Sbjct: 1357 MEVCKKIALSATDLKIQSTAEGIQLYSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGE 1416
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
+ L+I + +D G+Y E+ + K TV+
Sbjct: 1417 QIWLQINEPTPNDKGKYVMELFDGKTGHQKTVD 1449
Score = 41.5 bits (93), Expect = 0.032
Identities = 31/124 (25%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 1358 YKLRLENNCGHADVE--MNVTI----LDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+++R N+ G + VT+ LD P PGK +S+ + W+E ++
Sbjct: 710 FRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDA--KE 767
Query: 1412 IIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
++ Y +E + +W N + ++ + L T SY FR AVN +S+ S+ +E
Sbjct: 768 LVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSE 827
Query: 1470 YYKV 1473
+V
Sbjct: 828 AIEV 831
Score = 41.1 bits (92), Expect = 0.042
Identities = 19/82 (23%), Positives = 35/82 (42%)
Query: 842 ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDS 901
+T++E + L V +P P ++W +N + ++ + F+ N S DS
Sbjct: 1486 VTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADS 1545
Query: 902 GDYKCVASNSAGKSSHGARVTI 923
G Y V N G + V++
Sbjct: 1546 GKYGLVVKNKYGSETSDFTVSV 1567
Score = 40.3 bits (90), Expect = 0.074
Identities = 33/102 (32%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN----NEIISPSETITQNFDGENI 888
P FI + + TV EK +KL + P P +TWY+N N +P + I ++ G +
Sbjct: 277 PEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH- 335
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
L I D E D+ Y+ A N G+ S A V + K F
Sbjct: 336 TLEINACDFE-DTAQYRASAMNVKGELSAYASVVVKRYKGEF 376
Score = 39.5 bits (88), Expect = 0.13
Identities = 24/104 (23%), Positives = 44/104 (42%), Gaps = 4/104 (3%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P + EG + L C + P P+++WL + + D++ ++ E+ Y I
Sbjct: 1483 PDVVTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAY---FTING 1539
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ-VIEPLK 742
V G Y +V N+ G + + + E+E +E LK
Sbjct: 1540 VSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEEARMAALESLK 1583
Score = 39.1 bits (87), Expect = 0.17
Identities = 64/280 (22%), Positives = 115/280 (41%), Gaps = 40/280 (14%)
Query: 1126 FEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSK- 1184
FE + + W KD + S +++ G K K+ D +DD G YSC+V ++
Sbjct: 1062 FECDKMTPKSEFSWSKDYVSTEDSPRLEVESKGNKTKMTFKDLGMDDLGIYSCDVTDTDG 1121
Query: 1185 CTAILTVEEPSINFTLRLP---EFILVPANTDAYLTVEIPDETLDVTW------------ 1229
+ ++E + L L +F VP ++ L VEI ++ W
Sbjct: 1122 IASSYLIDEEELKRLLALSHEHKFPTVPVKSE--LAVEILEKGQVRFWMQAEKLSGNAKV 1179
Query: 1230 ---YKKKSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK----STTKLKV 1281
+ +K + E + K + + + + K ++D+ YT L D K ST L
Sbjct: 1180 NYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQLQDGKATNHSTVVLVG 1239
Query: 1282 EVVEFPPKIVDYER-EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH------- 1333
+V + K +++R E+ K+G + ++ + N IKK H
Sbjct: 1240 DVFKKLQKEAEFQRQEWIRKQGPHFVEYLSWEVTGECNVLLKCKVANIKKETHIVWYKDE 1299
Query: 1334 TKPSIDSKS------ASLTIKKVENTDAGIYKLRLENNCG 1367
+ S+D K +L I + DAGIY++ L+++ G
Sbjct: 1300 REISVDEKHDFKDGICTLLITEFSKKDAGIYEVILKDDRG 1339
Score = 39.1 bits (87), Expect = 0.17
Identities = 20/89 (22%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G + C V G P P+++W + + + ++ A I V D+G +
Sbjct: 1490 EGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGKYG 1549
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEM 611
V KN G S T++ V + + + M
Sbjct: 1550 LVVKNKYG--SETSDFTVSVFIPEEEARM 1576
Score = 38.3 bits (85), Expect = 0.30
Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 9/90 (10%)
Query: 747 RQGESVILSAQVVGNP-----RPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVK 798
R+GE++ L +VV P +P I W +N P+ K + T G+ ++T K +
Sbjct: 417 REGETMSLGCRVVITPEIKHFQPEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNK-E 475
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEE 828
DEG+YT++ E + SA + V + E
Sbjct: 476 DEGLYTIRVRMGEYYEQYSAYVFVRDADAE 505
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/93 (26%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 1433 ITKTQTSIQNLKTNSSYRFRAYAVNE----VDISDASETTEYY--KVIKETKIQSPT-VE 1485
++K TS + S + R + E + + E TE Y K+ ++ + +P +
Sbjct: 222 VSKQATSALQQEETSEKKSRKVVIREKAERLSLRKTLEETETYHAKLNEDHLLHAPEFII 281
Query: 1486 KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
KP + E E+++L C G P+P+VTWY++
Sbjct: 282 KPRSHTVWE-KENVKLHCSIAGWPEPRVTWYKN 313
Score = 36.3 bits (80), Expect = 1.2
Identities = 20/80 (25%), Positives = 35/80 (43%), Gaps = 1/80 (1%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS-KSASLTIKKVENTDAGI 1357
I+ G + L + P P W+ N K + H ++ ++A TI V D+G
Sbjct: 1488 IQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGK 1547
Query: 1358 YKLRLENNCGHADVEMNVTI 1377
Y L ++N G + V++
Sbjct: 1548 YGLVVKNKYGSETSDFTVSV 1567
Score = 34.3 bits (75), Expect = 4.9
Identities = 32/102 (31%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI-SVAIESDMHMYC 692
P F KP++ V E ++ L C + PEP + W I N IES M+
Sbjct: 277 PEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH- 335
Query: 693 SVLKITNVKKFQE-GTYTVVAVNREGEAS--LPIVLKIKTGE 731
L+I N F++ Y A+N +GE S +V+K GE
Sbjct: 336 -TLEI-NACDFEDTAQYRASAMNVKGELSAYASVVVKRYKGE 375
>AY518390-1|AAR89909.1| 1273|Homo sapiens myosin binding protein C,
cardiac protein.
Length = 1273
Score = 139 bits (336), Expect = 1e-31
Identities = 114/462 (24%), Positives = 200/462 (43%), Gaps = 28/462 (6%)
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASL-TIKKVENTDAGIYKLRLENNCGHADVEMNVT 1376
+DEW+ + K++ + + +K S+ T++ E D G+Y + ++N G V + V
Sbjct: 707 SDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVK 766
Query: 1377 ILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--IT 1434
++D P P P I + S + W+ P G I+ Y++E ++ + W+ + I
Sbjct: 767 VIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQ 826
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI----KETKIQSPTVEKPLKN 1490
+ + + Y R YAVN + +S S ++ + I + T + V +
Sbjct: 827 ELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTVS 886
Query: 1491 ITTEPNEDIELTCIFGGVPQPKVTWYRDG-KKLKTAKATYENRXXXXXXXXXXXXXXXYK 1549
+ P E + GG+ V + +G + A ++
Sbjct: 887 LKWRPPERVGA----GGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFR 942
Query: 1550 CIAFNDHGE---VETSCVVGIQ---QKPVITISNEDIKQ--KHKVGDEWLVTAVIEGIPP 1601
A N G V T+ V +Q Q+P + + ++Q + KVG+ + +G P
Sbjct: 943 VRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRH-LRQTIQKKVGEPVNLLIPFQGKPR 1001
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P+V W K G L + E +I +++ I+ +R HS Y + + L+
Sbjct: 1002 PQVTWTKEGQPLAGE-EVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQ 1060
Query: 1662 VYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
V DKPS P+ + + + +V +EWKPP D G EL Y ++K + W V + R
Sbjct: 1061 VVDKPSPPQ-DLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYR 1119
Query: 1722 DVETYC-IQKLNENCEYMFRVIAQNPVGFSE--ALESEPIVI 1760
T+C + +L Y FRV +QN VGFS+ A EP+ I
Sbjct: 1120 --RTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFI 1159
Score = 112 bits (269), Expect = 2e-23
Identities = 109/468 (23%), Positives = 195/468 (41%), Gaps = 38/468 (8%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPV 1673
E + + T + S+ ++ ++ YT+ N G V +T+KV D P P P
Sbjct: 719 ETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPK 778
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVETYCIQKLN 1732
I + +S T++W+PP DGG + Y +E+ + + RW+++ D+ +++ ++ +++
Sbjct: 779 ISN-VGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQEL-SHEARRMI 836
Query: 1733 ENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPS 1791
E Y RV A N +G S + S+P + + PS + + +V + W P
Sbjct: 837 EGVVYEMRVYAVNAIGMSRPSPASQPFM---PIGPPS-EPTHLAVEDVSDTTVSLKWRPP 892
Query: 1792 EKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXXARI--QKLSINTTYQFRIYARNEIGTS 1848
E+ G + Y VE EG +W I + L FR+ A N G
Sbjct: 893 ERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPG 952
Query: 1849 LPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEF--KT 1906
P T+ + +T+ + L P + ++ + V G P+ N +I F K
Sbjct: 953 APVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKV-----------GEPV-NLLIPFQGKP 1000
Query: 1907 VKGKSWTKI-VTVGGSVHEHCIENIKEKDEIIFRISA----ENTVGVSLPTESQSVRLEK 1961
+WTK + G E I N D I+F +A T V++ E+ +
Sbjct: 1001 RPQVTWTKEGQPLAG--EEVSIRN-SPTDTILFIRAARRVHSGTYQVTVRIENMEDKATL 1057
Query: 1962 HATVPSPPTAPLEIRMV---GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
V P+ P ++R+ G N+ + W P+ G L GY + D W V +
Sbjct: 1058 VLQVVDKPSPPQDLRVTDAWGLNVAL-EWKPPQDVGNTELWGYTVQKADKKTMEWFTVLE 1116
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEG 2066
+ +L + Y R++++N +G S+ + + IP G
Sbjct: 1117 -HYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPRPG 1163
Score = 111 bits (267), Expect = 3e-23
Identities = 80/257 (31%), Positives = 129/257 (50%), Gaps = 11/257 (4%)
Query: 1019 FIRKLQD-FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
F +KL+ ++V + L VE+ A+V W ++G+ I+ +Y FE G R L I
Sbjct: 365 FQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQ-MSGRYIFESIGAKRTLTIS 423
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR-LQNQKVNKGNKATFEIELTKGDAL 1136
S+ D+ Y C++ E C+ E+ V E PP +ITR L++Q V G + FE E+++ A
Sbjct: 424 QCSLADDAAYQCVVGGEKCSTELFVKE-PPVLITRPLEDQLVMVGQRVEFECEVSEEGAQ 482
Query: 1137 VRWFKDGSEIQFSNHIQLTI--DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEP 1194
V+W KDG E+ + DG++ L I + L+DAG Y+ + A L V+E
Sbjct: 483 VKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEK 542
Query: 1195 SINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK-KSVIEDTE-KFTLISDVKKRT 1252
+ + + ++V A A E+ DE + W K K ++ D+ K + I V K
Sbjct: 543 KLEVYQSIAD-LMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHK-- 599
Query: 1253 LIIRKCTEDDQCEYTCV 1269
L I T D+ +Y+ V
Sbjct: 600 LTIDDVTPADEADYSFV 616
Score = 101 bits (241), Expect = 4e-20
Identities = 80/284 (28%), Positives = 124/284 (43%), Gaps = 7/284 (2%)
Query: 924 DVEKVT-FVKHLQKSYETEEGKTVILECQTS-HTVSTKWYHNKKEISGMDHREIIQE-GR 980
D +K T F K L+ +Y+ +G + L + + H KW N +EI M R I + G
Sbjct: 358 DEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQ-MSGRYIFESIGA 416
Query: 981 XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D +C+V ++ ST L VKE R L+D V E E+
Sbjct: 417 KRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEV 476
Query: 1041 NSETADVVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
+ E A V W +DG E+ + + KY F+K G L I + D G Y+ AE
Sbjct: 477 SEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAE 536
Query: 1100 VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGK 1159
+ V E E+ + + V ++A F+ E++ + W K+G E+ + I+++ G+
Sbjct: 537 LIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGR 596
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKC--TAILTVEEPSINFTLR 1201
KL I D D +YS C +A L E I+F R
Sbjct: 597 VHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPR 640
Score = 84.2 bits (199), Expect = 5e-15
Identities = 54/168 (32%), Positives = 77/168 (45%), Gaps = 3/168 (1%)
Query: 1117 KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY 1176
+V+KG+K +EL DA V+W K+G EIQ S G K+ L I C L D Y
Sbjct: 374 QVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGRYIFESIGAKRTLTISQCSLADDAAY 433
Query: 1177 SCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK--KS 1234
C VG KC+ L V+EP + T L E LV E+ +E V W K +
Sbjct: 434 QCVVGGEKCSTELFVKEPPVLITRPL-EDQLVMVGQRVEFECEVSEEGAQVKWLKDGVEL 492
Query: 1235 VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
E+T K+ D ++ LII + +D Y ++ +L V+
Sbjct: 493 TREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQ 540
Score = 83.4 bits (197), Expect = 8e-15
Identities = 60/239 (25%), Positives = 106/239 (44%), Gaps = 19/239 (7%)
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
K G V LL+ +Q P+P W + + + L I+ +G Y+
Sbjct: 985 KVGEPVNLLIPFQGKPRPQVTWTKEGQPLAG-EEVSIRNSPTDTILFIRAARRVHSGTYQ 1043
Query: 1360 L--RLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
+ R+EN A + + V +DKPSPP + + ++ + W P++ GN+ + Y V
Sbjct: 1044 VTVRIENMEDKATLVLQV--VDKPSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTV 1101
Query: 1418 EYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ + T EW +V ++ +T + L + Y FR ++ N V SD + TT+ I
Sbjct: 1102 QKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPR 1161
Query: 1477 TKI-------------QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
I ++P+ +PL N + L C G P+PK++W+++G L
Sbjct: 1162 PGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDL 1220
Score = 79.8 bits (188), Expect = 1e-13
Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 8/155 (5%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTS 1986
+E +++DE ++ ++ +N VG E Q K VP P AP +I VG +
Sbjct: 737 VEGAEKEDEGVYTVTVKNPVG-----EDQVNLTVKVIDVPDAPAAP-KISNVGEDSCTVQ 790
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNE 2046
W P +DGG P+LGY + + WM + + L R + E Y +R+YA N
Sbjct: 791 WEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMIEGVVYEMRVYAVNA 850
Query: 2047 IGLSEPLESDEPFKVI--PGEGSHADEEPGEQTEV 2079
IG+S P + +PF I P E +H E T V
Sbjct: 851 IGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTV 885
Score = 56.4 bits (130), Expect = 1e-06
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 1/97 (1%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F + L + G T C V G P+P+I+WF+ + F+M + V
Sbjct: 1177 SEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRM-FSKQGVL 1235
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
TL IR+ P D G + C A N G A L V P
Sbjct: 1236 TLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVP 1272
Score = 47.2 bits (107), Expect = 6e-04
Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 3/100 (3%)
Query: 1192 EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKR 1251
E+ S F +L V LTVE+ D +V W K I+ + ++ S KR
Sbjct: 359 EKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGRYIFESIGAKR 418
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
TL I +C+ D Y CV+ K +T+L V+ PP ++
Sbjct: 419 TLTISQCSLADDAAYQCVVGGEKCSTEL---FVKEPPVLI 455
Score = 46.4 bits (105), Expect = 0.001
Identities = 26/77 (33%), Positives = 37/77 (48%)
Query: 1117 KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY 1176
+V G+ A FE E + VRW + GS+I SN L +G + L + + D G Y
Sbjct: 20 EVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSY 79
Query: 1177 SCEVGNSKCTAILTVEE 1193
+ G+SK L V E
Sbjct: 80 AVIAGSSKVKFDLKVIE 96
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/92 (27%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 1013 KETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
K+ + F +K + EV A+ E E V W+R G I NKY G
Sbjct: 6 KKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISAS-NKYGLATEGTRH 64
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTVVE 1104
L +R D+G Y+ I ++ V+E
Sbjct: 65 TLTVREVGPADQGSYAVIAGSSKVKFDLKVIE 96
Score = 40.3 bits (90), Expect = 0.074
Identities = 18/72 (25%), Positives = 34/72 (47%)
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
++ + G P P++ W+KNG L D + + +K+ + I++ Y A+N
Sbjct: 1198 MLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNL 1257
Query: 1651 AGTSSVEVTLKV 1662
G + E L+V
Sbjct: 1258 QGEARCECRLEV 1269
Score = 39.9 bits (89), Expect = 0.098
Identities = 28/96 (29%), Positives = 42/96 (43%), Gaps = 4/96 (4%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSI 789
E P +PL + V G + +L V G+P+P I+W KN + S ++
Sbjct: 1178 EAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTL 1237
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
I KP D G+Y +A N +G A + V P
Sbjct: 1238 EIRKPCPF-DGGIYVCRATNLQGEARCECRLEVRVP 1272
Score = 37.9 bits (84), Expect = 0.39
Identities = 43/177 (24%), Positives = 72/177 (40%), Gaps = 22/177 (12%)
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV----AVNREGEASLP 722
WL G+E+VPD I V+ +H L I +V E Y+ V A N +
Sbjct: 576 WLKNGKELVPDSRIKVSHIGRVHK----LTIDDVTPADEADYSFVPEGFACNLSAKLHFM 631
Query: 723 IVLKIKTGEKEPPQVIEPL-----KSMIVRQGESVILSAQVVGNPRPTITWCK-----NN 772
V +EPP++ +++V G + L + G+P PT+ W K N
Sbjct: 632 EVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNK 691
Query: 773 KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
P + P + S + KK+ E ++ E + + ++ TVE +E+
Sbjct: 692 APARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETT----KDRSIFTVEGAEKED 744
Score = 36.3 bits (80), Expect = 1.2
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVY--TL 805
GE V L G PRP +TW K +P+ + T +I ++ + G Y T+
Sbjct: 987 GEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRVHSGTYQVTV 1046
Query: 806 KAENSEGIAETSAVITVEEPT 826
+ EN E A T + V++P+
Sbjct: 1047 RIENMEDKA-TLVLQVVDKPS 1066
>BC043916-1|AAH43916.1| 767|Homo sapiens OBSCN protein protein.
Length = 767
Score = 138 bits (335), Expect = 2e-31
Identities = 139/555 (25%), Positives = 225/555 (40%), Gaps = 27/555 (4%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSIT 790
P + PL+ R+ +SV+LS P+ + W K++ P+ + +G +
Sbjct: 225 PVVLTRPLEPKTGRELQSVVLSCDFRPAPK-AVQWYKDDTPLSPSEKFKMSLEGQMAELR 283
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
IL+ D GVY +A G A +S +TVE E PL Q+ E+G
Sbjct: 284 ILRLMPA-DAGVYRCQA----GSAHSSTEVTVEA-REVTVTGPL-----QDAEATEEGWA 332
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
++ + W N + + G LV+ ++ D+G +
Sbjct: 333 SFSCELSHED-EEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQ-RADAG----IVRA 386
Query: 911 SAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISG 969
S+ K S AR+ + V+ V F+K L EE T+ L+C+ S + W + ++
Sbjct: 387 SSLKVSTSARLEVRVKPVVFLKALD-DLSAEERGTLALQCEVSDPEAHVVWRKDGVQLGP 445
Query: 970 MDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVK 1029
D + + D G+ C V +ET + V + ++L+ EV
Sbjct: 446 SDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVL 505
Query: 1030 EKDVAILEVEINSETAD--VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEY 1087
E + E ++ E+A +W G+ + +++ ++G L +R + D GE
Sbjct: 506 EGESCSFECVLSHESASDPAMWTVGGKTVG-SSSRFQATRQGRKYILVVREAAPSDAGEV 564
Query: 1088 SCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQ 1147
+R + A + V E P II L++Q V G EL++ V W KD I+
Sbjct: 565 VFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTPVHWLKDRKAIR 624
Query: 1148 FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFIL 1207
S + +G L I L DAGEY+CEV SK TA L VEE + FT L +
Sbjct: 625 KSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTN-LQ 683
Query: 1208 VPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
V A T + VTW K + + K + L I + D YT
Sbjct: 684 VEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYT 743
Query: 1268 CVLLDAKSTTKLKVE 1282
C + A+S +L V+
Sbjct: 744 CDIGQAQSRAQLLVQ 758
Score = 123 bits (297), Expect = 6e-27
Identities = 141/664 (21%), Positives = 253/664 (38%), Gaps = 36/664 (5%)
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G VA N E A L + ++ P ++ PL+ I + +L QV
Sbjct: 25 GEIQFVAENAESRAQLRV-------KELPVTLVRPLRDKIAMEKHRGVLECQV-SRASAQ 76
Query: 766 ITWCKNNKPVKALPTK---SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+ W K ++ ++ P SDG + I+ +DE YT A G +TSA V
Sbjct: 77 VRWFKGSQELQPGPKYELVSDGLYRKL-IISDVHAEDEDTYTCDA----GDVKTSAQFFV 131
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
EE + + Q++TV E + V W ++ +
Sbjct: 132 EE------QSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGNVGLE 185
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
+G L++ S + + V GKS AR+ + V + L+ E
Sbjct: 186 QEGTVHRLMLRRTCSTMTGPVHFTV-----GKSRSSARLVVSDIPVVLTRPLEPK-TGRE 239
Query: 943 GKTVILECQTSHTV-STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
++V+L C + +WY + +S + ++ EG+ D GV +C
Sbjct: 240 LQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 299
Query: 1002 KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKN 1061
+ST + V+ LQD E E+ A E++ E +V W +G + +
Sbjct: 300 GSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLNGMPLY-NDS 358
Query: 1062 KYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKG 1121
++ +G L +++ D G S +A + V P + L + +
Sbjct: 359 FHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEER 418
Query: 1122 NKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG 1181
+ E++ +A V W KDG ++ S+ + L ++D +DAG Y+C VG
Sbjct: 419 GTLALQCEVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVG 478
Query: 1182 NSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTE 1240
+ + A + V + + T RL ++ + ++ V + D W + +
Sbjct: 479 SEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSS 538
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS-TTKLKVEVVEFPPKIVDYEREYRI 1299
+F +K L++R+ D E V+ + T+K + V E P I+ + +
Sbjct: 539 RFQATRQGRKYILVVREAAPSDAGE---VVFSVRGLTSKASLIVRERPAAIIKPLEDQWV 595
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
G DV L + P W+ + K I+K + + A L I+ DAG Y
Sbjct: 596 APGEDVELRCELSRAGTPV-HWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYT 654
Query: 1360 LRLE 1363
+E
Sbjct: 655 CEVE 658
Score = 103 bits (248), Expect = 5e-21
Identities = 133/648 (20%), Positives = 255/648 (39%), Gaps = 33/648 (5%)
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG 943
+G L+ V +E D+G+ + VA N+ + A++ + VT V+ L+ E+
Sbjct: 8 EGRTYTLIYRRVLAE-DAGEIQFVAENAESR----AQLRVKELPVTLVRPLRDKIAMEKH 62
Query: 944 KTVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVK 1002
+ V LECQ S + +W+ +E+ E++ +G D C
Sbjct: 63 RGV-LECQVSRASAQVRWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAG 121
Query: 1003 DQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNK 1062
D +TS V+E +R LQD V E A E E + + G+ +
Sbjct: 122 DVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGN 181
Query: 1063 YDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGN 1122
E+ G + +L +R T G + +A + V ++P + L+ + +
Sbjct: 182 VGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQ 241
Query: 1123 KATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ V+W+KD + + S +++++G+ +L+I DAG Y C+ G+
Sbjct: 242 SVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGS 301
Query: 1183 SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKF 1242
+ + +TVE + T L + A + E+ E +V W + +
Sbjct: 302 AHSSTEVTVEAREVTVTGPLQDAEATEEGW-ASFSCELSHEDEEVEWSLNGMPLYNDSFH 360
Query: 1243 TLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV--VEFPPKIVDYEREYRIK 1300
+ ++ TL+++ D L ++ +L+V V V F + D E +
Sbjct: 361 EISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAE---E 417
Query: 1301 RGSDVTLLVDYQ-AFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
RG TL + + + P+ + W + + + + L + V DAG+Y
Sbjct: 418 RG---TLALQCEVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYT 474
Query: 1360 LRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEY 1419
+ + A V ++ + +LE +S S C E+ + +
Sbjct: 475 CHVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFE-CVLSHESASDPAMW------ 527
Query: 1420 QEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYA-VNEVDISDASETTEYYKVIKETK 1478
T +V + ++ Q + Q K R A + EV S T++ +++E
Sbjct: 528 ----TVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIVRE-- 581
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK 1526
+ + KPL++ P ED+EL C P V W +D K ++ ++
Sbjct: 582 -RPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQ 627
Score = 100 bits (240), Expect = 5e-20
Identities = 93/390 (23%), Positives = 159/390 (40%), Gaps = 6/390 (1%)
Query: 971 DHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKE 1030
D+ I QEGR D G I+ + ++ E+ L VKE +R L+D E
Sbjct: 1 DNVRIRQEGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAME 60
Query: 1031 KDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI 1090
K +LE +++ +A V W + + ++P KY+ G RKL I + DE Y+C
Sbjct: 61 KHRGVLECQVSRASAQVRWFKGSQELQPGP-KYELVSDGLYRKLIISDVHAEDEDTYTCD 119
Query: 1091 LRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFS 1149
D +A+ V E I+ LQ+ V + A FE E + +W + +Q
Sbjct: 120 AGDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAG 179
Query: 1150 NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVP 1209
++ L +G +L + G VG S+ +A L V + + T L E
Sbjct: 180 GNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPL-EPKTGR 238
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
L+ + V WYK + + +EKF + + + L I + D Y C
Sbjct: 239 ELQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQ 298
Query: 1270 LLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIK 1329
A S+T++ VE E + E + + + + ++ EW +N +
Sbjct: 299 AGSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLY 355
Query: 1330 KCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
+ S + +L +K ++ DAGI +
Sbjct: 356 NDSFHEISHKGRRHTLVLKSIQRADAGIVR 385
Score = 92.3 bits (219), Expect = 2e-17
Identities = 75/311 (24%), Positives = 134/311 (43%), Gaps = 9/311 (2%)
Query: 1067 KRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATF 1126
+ G L R D GE + + A++ V ELP ++ L+++ + ++
Sbjct: 7 QEGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVL 66
Query: 1127 EIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT 1186
E ++++ A VRWFK E+Q +L DG +KL I D +D Y+C+ G+ K +
Sbjct: 67 ECQVSRASAQVRWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTS 126
Query: 1187 AILTVEEPSINFTLRLPEF-ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLI 1245
A VEE SI L + ++ PA IP W K+V++ L
Sbjct: 127 AQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIP-SVRPPKWLLGKTVLQAGGNVGLE 185
Query: 1246 SDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRG-SD 1304
+ L++R+ + ++S+ +L VV P ++ E + R
Sbjct: 186 QEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARL---VVSDIPVVLTRPLEPKTGRELQS 242
Query: 1305 VTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLEN 1364
V L D++ P+ +W + + + K S++ + A L I ++ DAG+Y R +
Sbjct: 243 VVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVY--RCQA 299
Query: 1365 NCGHADVEMNV 1375
H+ E+ V
Sbjct: 300 GSAHSSTEVTV 310
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+ L PK + +V C P+ + W++ + PS+ F+M + +A L I
Sbjct: 227 VLTRPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQ-MAELRI 284
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+ P DAG + C AG A S+TE+ VEA
Sbjct: 285 LRLMPADAGVYRC----QAGSAHSSTEVTVEA 312
Score = 39.1 bits (87), Expect = 0.17
Identities = 38/180 (21%), Positives = 74/180 (41%), Gaps = 11/180 (6%)
Query: 1486 KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXXXXXXXXXX 1542
+PL+ T + + L+C F P+ V WY+D L + K + E +
Sbjct: 230 RPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLM 288
Query: 1543 -XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y+C A + H E V ++ + V T++ ++ + W +
Sbjct: 289 PADAGVYRCQAGSAHSSTE----VTVEAREV-TVTGP-LQDAEATEEGWASFSCELSHED 342
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
EV W NG L ND + I+ K + + +K ++R+ + + + ++ +EV +K
Sbjct: 343 EEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVK 402
Score = 39.1 bits (87), Expect = 0.17
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F++ L + T+ +C+V P + W + + PS + + LV+
Sbjct: 405 VFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTA-GTRGLVV 462
Query: 571 REVFPEDAGTFTC 583
+V PEDAG +TC
Sbjct: 463 HDVSPEDAGLYTC 475
Score = 37.1 bits (82), Expect = 0.69
Identities = 27/97 (27%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
V LR K + ECQV Q+ WF+ + ++P +++ D L+I +
Sbjct: 50 VRPLRDKIAMEKHRGVLECQVSR-ASAQVRWFKGSQELQPGPKYELV-SDGLYRKLIISD 107
Query: 573 VFPEDAGTFTCVA---KNAAGFASSTTELIVEAPLSD 606
V ED T+TC A K +A F + + L D
Sbjct: 108 VHAEDEDTYTCDAGDVKTSAQFFVEEQSITIVRGLQD 144
Score = 36.7 bits (81), Expect = 0.91
Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 2/85 (2%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
++ L + G V+ C++ P + W + I+ SQ + + + +A LVIR
Sbjct: 587 IKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQKYDVVCEG-TMAMLVIRG 644
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTE 597
+DAG +TC + + AS E
Sbjct: 645 ASLKDAGEYTCEVEASKSTASLHVE 669
>AL353593-1|CAI19283.1| 709|Homo sapiens obscurin, cytoskeletal
calmodulin and titin-interacting RhoGEF protein.
Length = 709
Score = 138 bits (335), Expect = 2e-31
Identities = 139/555 (25%), Positives = 225/555 (40%), Gaps = 27/555 (4%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSIT 790
P + PL+ R+ +SV+LS P+ + W K++ P+ + +G +
Sbjct: 167 PVVLTRPLEPKTGRELQSVVLSCDFRPAPK-AVQWYKDDTPLSPSEKFKMSLEGQMAELR 225
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
IL+ D GVY +A G A +S +TVE E PL Q+ E+G
Sbjct: 226 ILRLMPA-DAGVYRCQA----GSAHSSTEVTVEA-REVTVTGPL-----QDAEATEEGWA 274
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
++ + W N + + G LV+ ++ D+G +
Sbjct: 275 SFSCELSHED-EEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQ-RADAG----IVRA 328
Query: 911 SAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS-TKWYHNKKEISG 969
S+ K S AR+ + V+ V F+K L EE T+ L+C+ S + W + ++
Sbjct: 329 SSLKVSTSARLEVRVKPVVFLKALD-DLSAEERGTLALQCEVSDPEAHVVWRKDGVQLGP 387
Query: 970 MDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVK 1029
D + + D G+ C V +ET + V + ++L+ EV
Sbjct: 388 SDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVL 447
Query: 1030 EKDVAILEVEINSETAD--VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEY 1087
E + E ++ E+A +W G+ + +++ ++G L +R + D GE
Sbjct: 448 EGESCSFECVLSHESASDPAMWTVGGKTVG-SSSRFQATRQGRKYILVVREAAPSDAGEV 506
Query: 1088 SCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQ 1147
+R + A + V E P II L++Q V G EL++ V W KD I+
Sbjct: 507 VFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTPVHWLKDRKAIR 566
Query: 1148 FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFIL 1207
S + +G L I L DAGEY+CEV SK TA L VEE + FT L +
Sbjct: 567 KSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASLHVEEKANCFTEELTN-LQ 625
Query: 1208 VPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
V A T + VTW K + + K + L I + D YT
Sbjct: 626 VEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYT 685
Query: 1268 CVLLDAKSTTKLKVE 1282
C + A+S +L V+
Sbjct: 686 CDIGQAQSRAQLLVQ 700
Score = 114 bits (275), Expect = 3e-24
Identities = 130/617 (21%), Positives = 235/617 (38%), Gaps = 29/617 (4%)
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTK---SDGDTHSITILKPKKVKDEGVYTLKAEN 809
+L QV + W K ++ ++ P SDG + I+ +DE YT A
Sbjct: 7 VLECQV-SRASAQVRWFKGSQELQPGPKYELVSDGLYRKL-IISDVHAEDEDTYTCDA-- 62
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
G +TSA VEE + + Q++TV E + V W
Sbjct: 63 --GDVKTSAQFFVEE------QSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLG 114
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
++ + +G L++ S + + V GKS AR+ + V
Sbjct: 115 KTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTV-----GKSRSSARLVVSDIPVV 169
Query: 930 FVKHLQKSYETEEGKTVILECQTSHTV-STKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ L+ E ++V+L C + +WY + +S + ++ EG+
Sbjct: 170 LTRPLEPK-TGRELQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILR 228
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV 1048
D GV +C +ST + V+ LQD E E+ A E++ E +V
Sbjct: 229 LMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVE 288
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPE 1108
W +G + + ++ +G L +++ D G S +A + V P
Sbjct: 289 WSLNGMPLY-NDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVV 347
Query: 1109 IITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDC 1168
+ L + + + E++ +A V W KDG ++ S+ + L ++D
Sbjct: 348 FLKALDDLSAEERGTLALQCEVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDV 407
Query: 1169 DLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-V 1227
+DAG Y+C VG+ + A + V + + T RL ++ + ++ V + D
Sbjct: 408 SPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPA 467
Query: 1228 TWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS-TTKLKVEVVEF 1286
W + + +F +K L++R+ D E V+ + T+K + V E
Sbjct: 468 MWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGE---VVFSVRGLTSKASLIVRER 524
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
P I+ + + G DV L + P W+ + K I+K + + A L
Sbjct: 525 PAAIIKPLEDQWVAPGEDVELRCELSRAGTPV-HWLKDRKAIRKSQKYDVVCEGTMAMLV 583
Query: 1347 IKKVENTDAGIYKLRLE 1363
I+ DAG Y +E
Sbjct: 584 IRGASLKDAGEYTCEVE 600
Score = 77.4 bits (182), Expect = 5e-13
Identities = 76/331 (22%), Positives = 134/331 (40%), Gaps = 6/331 (1%)
Query: 1030 EKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
EK +LE +++ +A V W + + ++P KY+ G RKL I + DE Y+C
Sbjct: 2 EKHRGVLECQVSRASAQVRWFKGSQELQPGP-KYELVSDGLYRKLIISDVHAEDEDTYTC 60
Query: 1090 ILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQF 1148
D +A+ V E I+ LQ+ V + A FE E + +W + +Q
Sbjct: 61 DAGDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQA 120
Query: 1149 SNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILV 1208
++ L +G +L + G VG S+ +A L V + + T L E
Sbjct: 121 GGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPL-EPKTG 179
Query: 1209 PANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC 1268
L+ + V WYK + + +EKF + + + L I + D Y C
Sbjct: 180 RELQSVVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRC 239
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
A S+T++ VE E + E + + + + ++ EW +N +
Sbjct: 240 QAGSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPL 296
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
+ S + +L +K ++ DAGI +
Sbjct: 297 YNDSFHEISHKGRRHTLVLKSIQRADAGIVR 327
Score = 74.1 bits (174), Expect = 5e-12
Identities = 63/256 (24%), Positives = 111/256 (43%), Gaps = 9/256 (3%)
Query: 1122 NKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG 1181
++ E ++++ A VRWFK E+Q +L DG +KL I D +D Y+C+ G
Sbjct: 4 HRGVLECQVSRASAQVRWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAG 63
Query: 1182 NSKCTAILTVEEPSINFTLRLPEF-ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE 1240
+ K +A VEE SI L + ++ PA IP W K+V++
Sbjct: 64 DVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIP-SVRPPKWLLGKTVLQAGG 122
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIK 1300
L + L++R+ + ++S+ +L VV P ++ E +
Sbjct: 123 NVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARL---VVSDIPVVLTRPLEPKTG 179
Query: 1301 RG-SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYK 1359
R V L D++ P+ +W + + + K S++ + A L I ++ DAG+Y
Sbjct: 180 RELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVY- 237
Query: 1360 LRLENNCGHADVEMNV 1375
R + H+ E+ V
Sbjct: 238 -RCQAGSAHSSTEVTV 252
Score = 52.0 bits (119), Expect = 2e-05
Identities = 45/178 (25%), Positives = 81/178 (45%), Gaps = 17/178 (9%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD---GDTHS 788
+ P +I+PL+ V GE V L ++ P + W K+ K ++ K D T +
Sbjct: 523 ERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRK-SQKYDVVCEGTMA 580
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+ +++ +KD G YT + E S +++A + VEE F + V+EKG
Sbjct: 581 MLVIRGASLKDAGEYTCEVEAS----KSTASLHVEEKAN------CFTEELTNLQVEEKG 630
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
T + T +P ++TW + + S + +G + L I+ ++ + DS Y C
Sbjct: 631 TAVFTCK-TEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALE-KADSDTYTC 686
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+ L PK + +V C P+ + W++ + PS+ F+M + +A L I
Sbjct: 169 VLTRPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQ-MAELRI 226
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+ P DAG + C AG A S+TE+ VEA
Sbjct: 227 LRLMPADAGVYRC----QAGSAHSSTEVTVEA 254
Score = 39.1 bits (87), Expect = 0.17
Identities = 38/180 (21%), Positives = 74/180 (41%), Gaps = 11/180 (6%)
Query: 1486 KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXXXXXXXXXX 1542
+PL+ T + + L+C F P+ V WY+D L + K + E +
Sbjct: 172 RPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLM 230
Query: 1543 -XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y+C A + H E V ++ + V T++ ++ + W +
Sbjct: 231 PADAGVYRCQAGSAHSSTE----VTVEAREV-TVTGP-LQDAEATEEGWASFSCELSHED 284
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
EV W NG L ND + I+ K + + +K ++R+ + + + ++ +EV +K
Sbjct: 285 EEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVK 344
Score = 39.1 bits (87), Expect = 0.17
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F++ L + T+ +C+V P + W + + PS + + LV+
Sbjct: 347 VFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTA-GTRGLVV 404
Query: 571 REVFPEDAGTFTC 583
+V PEDAG +TC
Sbjct: 405 HDVSPEDAGLYTC 417
Score = 36.7 bits (81), Expect = 0.91
Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 2/85 (2%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
++ L + G V+ C++ P + W + I+ SQ + + + +A LVIR
Sbjct: 529 IKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQKYDVVCEG-TMAMLVIRG 586
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTE 597
+DAG +TC + + AS E
Sbjct: 587 ASLKDAGEYTCEVEASKSTASLHVE 611
Score = 35.5 bits (78), Expect = 2.1
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 5/80 (6%)
Query: 530 ECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVA---K 586
ECQV Q+ WF+ + ++P +++ D L+I +V ED T+TC A K
Sbjct: 9 ECQVSR-ASAQVRWFKGSQELQPGPKYELV-SDGLYRKLIISDVHAEDEDTYTCDAGDVK 66
Query: 587 NAAGFASSTTELIVEAPLSD 606
+A F + + L D
Sbjct: 67 TSAQFFVEEQSITIVRGLQD 86
>AJ314900-1|CAC85747.1| 551|Homo sapiens obscurin protein.
Length = 551
Score = 137 bits (332), Expect = 4e-31
Identities = 125/535 (23%), Positives = 217/535 (40%), Gaps = 32/535 (5%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTL 805
G S LS +V + + W K+ K + + + ++ G + + + K D G Y+
Sbjct: 20 GASATLSCEVA-QAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKT-DAGDYSC 77
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+A S + + EP A+ N Q E G +++ +T
Sbjct: 78 EARGQR----VSFRLHITEPKMMFAKEQSVHNEVQA----EAGASAMLSCEVAQAQTEVT 129
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
WY++ + +S S + G LV+ + D+G+Y C AG + I
Sbjct: 130 WYKDGKKLSSSSKVGMEVKGCTRRLVLPQA-GKADAGEYSC----EAGGQRVSFHLHITE 184
Query: 926 EKVTFVKH--LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXX 982
K F K + + E G T +L C+ + WY + K++S + +G
Sbjct: 185 PKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTR 244
Query: 983 XXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRK-LQDFEVKEKD--VAILEVE 1039
D G C Q S L + E F ++ L EV+ + A L E
Sbjct: 245 RLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSCE 304
Query: 1040 INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
+ +V W +DG+ + +K E G +R+L ++ D GEY+C + +
Sbjct: 305 VAQAQTEVTWYKDGKKLS-SSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFH 363
Query: 1100 VTVVELPPEIITR--LQNQKVNK--GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLT 1155
+ V E P + + L ++KV G AT E+ + V W+KDG ++ S+ +++
Sbjct: 364 LDVSE-PKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRME 422
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAY 1215
G ++L + D GEYSCE G + + L V EP + F P V A A
Sbjct: 423 AVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGAS 482
Query: 1216 LTV--EIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC 1268
T+ E+ +V WYK + + K + + R L++++ + EY+C
Sbjct: 483 TTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSC 537
Score = 126 bits (305), Expect = 7e-28
Identities = 110/456 (24%), Positives = 185/456 (40%), Gaps = 30/456 (6%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTL 805
G S +LS +V + +TW K+ K + + + + G T + + + K D G Y+
Sbjct: 112 GASAMLSCEVA-QAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKA-DAGEYSC 169
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+A G S + + EP A+ N Q E GT +++ P +T
Sbjct: 170 EA----GGQRVSFHLHITEPKGVFAKEQSVHNEVQA----EAGTTAMLSCEVAQPQTEVT 221
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
WY++ + +S S + G LV+ V + D+G+Y C AG ++ I
Sbjct: 222 WYKDGKKLSSSSKVRMEVKGCTRRLVVQQV-GKADAGEYSC----EAGGQRVSFQLHITE 276
Query: 926 EKVTFVKH--LQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXX 982
K F K + TE G + L C+ + WY + K++S I G
Sbjct: 277 PKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMR 336
Query: 983 XXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKL---QDFEVKEKDVAILEVE 1039
D G C Q S L V E F ++ + + + +A L E
Sbjct: 337 QLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCE 396
Query: 1040 INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
+ +V W +DG+ + +K E G R+L ++ D GEYSC + +
Sbjct: 397 VAQAQTEVTWYKDGKKLS-SSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFS 455
Query: 1100 VTVVELPPEIITRLQ----NQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLT 1155
+ V E P + + Q + G T E+ + V W+KDG ++ FS+ +++
Sbjct: 456 LDVAE-PKVVFAKEQPVHREVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSSKVRME 514
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTV 1191
G ++L + AGEYSCE G+ + + L V
Sbjct: 515 AVGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHV 550
Score = 95.1 bits (226), Expect = 2e-18
Identities = 112/545 (20%), Positives = 209/545 (38%), Gaps = 39/545 (7%)
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
G AT E+ + V W+KDG ++ S + + G +++L + DAG+YSCE
Sbjct: 20 GASATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA 79
Query: 1181 GNSKCTAILTVEEPSINFTLR--LPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIED 1238
+ + L + EP + F + + A A L+ E+ +VTWYK +
Sbjct: 80 RGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTEVTWYKDGKKLSS 139
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV-EVVEFPPKIVDYEREY 1297
+ K + R L++ + + D EY+C + + L + E K E
Sbjct: 140 SSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHITEPKGVFAKEQSVHNEV 199
Query: 1298 RIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGI 1357
+ + G+ L + A PQ W + K + + + + L +++V DAG
Sbjct: 200 QAEAGTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGE 258
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVV 1417
Y G V + I + + K ++ + + E ++T+ V
Sbjct: 259 YSC----EAGGQRVSFQLHITEPKAVFAKEQLVHNEVRT--------EAGASATLSCEVA 306
Query: 1418 EYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETT--------E 1469
+ Q TE K+ K +S ++ ++ R V + +DA E T
Sbjct: 307 QAQ----TEVTWYKDGKKLSSS-SKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLS 361
Query: 1470 YYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL-KTAKAT 1528
++ + E K + + + E L+C Q +VTWY+DGKKL ++K
Sbjct: 362 FHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQA-QTEVTWYKDGKKLSSSSKVR 420
Query: 1529 YEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHK 1585
E Y C A G S + + + V+ + + ++ +
Sbjct: 421 MEAVGCTRRLVVQQACQADTGEYSCEA----GGQRLSFSLDVAEPKVVFAKEQPVHREVQ 476
Query: 1586 VGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
T E EV+WYK+G KL + + T + +++ ++ + +Y+
Sbjct: 477 AQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYS 536
Query: 1645 IEASN 1649
EA +
Sbjct: 537 CEAGS 541
Score = 53.6 bits (123), Expect = 7e-06
Identities = 88/460 (19%), Positives = 170/460 (36%), Gaps = 31/460 (6%)
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
A A L+ E+ +V WYK + + K + + +R L++++ + D +Y+C
Sbjct: 19 AGASATLSCEVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCE 78
Query: 1270 LLDAKSTTKLKV-EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII 1328
+ + +L + E K E + + G+ L + A Q W + K +
Sbjct: 79 ARGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEV-AQAQTEVTWYKDGKKL 137
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPN 1388
+ + L + + DAG Y G V ++ I + P G
Sbjct: 138 SSSSKVGMEVKGCTRRLVLPQAGKADAGEYSC----EAGGQRVSFHLHITE---PKG--- 187
Query: 1389 ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
+ + S N + G + ++ V + + T + K ++ + +K +
Sbjct: 188 VFAKEQSVHN---EVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVK-GCT 243
Query: 1449 YRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV----EKPLKN-ITTEPNEDIELTC 1503
R V + D + S +V + I P E+ + N + TE L+C
Sbjct: 244 RRLVVQQVGKADAGEYSCEAGGQRVSFQLHITEPKAVFAKEQLVHNEVRTEAGASATLSC 303
Query: 1504 IFGGVPQPKVTWYRDGKKL-KTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
Q +VTWY+DGKKL ++K E Y C A G
Sbjct: 304 EVAQA-QTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEA----GGQ 358
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE-GIPPPEVIWYKNGNKLENDKE 1618
S + + + + + +K + + T E EV WYK+G KL + +
Sbjct: 359 RLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSK 418
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
+ T + +++ ++ + +Y+ EA + S++V
Sbjct: 419 VRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDV 458
Score = 44.0 bits (99), Expect = 0.006
Identities = 43/193 (22%), Positives = 78/193 (40%), Gaps = 14/193 (7%)
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA-KATYENR 1532
I E K+ + + E L+C Q +VTWY+DGKKL ++ K E +
Sbjct: 90 ITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQA-QTEVTWYKDGKKLSSSSKVGMEVK 148
Query: 1533 XXXXXXX---XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDE 1589
Y C A G S + I + + + + ++V E
Sbjct: 149 GCTRRLVLPQAGKADAGEYSCEA----GGQRVSFHLHITEPKGVFAKEQSVH--NEVQAE 202
Query: 1590 WLVTAVIE---GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
TA++ P EV WYK+G KL + + + K T + ++++ ++ + +Y+ E
Sbjct: 203 AGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCE 262
Query: 1647 ASNTAGTSSVEVT 1659
A + + +T
Sbjct: 263 AGGQRVSFQLHIT 275
Score = 33.5 bits (73), Expect = 8.5
Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+T C+V P+ ++TW++ + S +M LV+++V DAG ++C
Sbjct: 204 GTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGCT-RRLVVQQVGKADAGEYSC 261
Query: 584 VA 585
A
Sbjct: 262 EA 263
>AB014557-1|BAA31632.2| 1237|Homo sapiens KIAA0657 protein protein.
Length = 1237
Score = 136 bits (329), Expect = 8e-31
Identities = 133/533 (24%), Positives = 225/533 (42%), Gaps = 29/533 (5%)
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
IL K +D G L + G+ + SA +T++E P ++ +T +
Sbjct: 518 ILHAVKHQDSGA--LVGFSCPGVQD-SAALTIQESPVHILSPQDKVS----LTFTTSERV 570
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
L ++R P+ TWY++ + + SE + DG L++ + DSG+++C
Sbjct: 571 VLTCELSRVDFPA-TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQ-DSGEFEC---R 625
Query: 911 SAGKSSHGARVTIDVEKVTFVKHLQKSY-ETEEGKTVILECQTSHT-VSTKWYHNKKEIS 968
+ G S+ VT+ V V + + + V+L C+ +WY + +E+
Sbjct: 626 TEGVSAFFG-VTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRWYKDGQEVE 684
Query: 969 GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQD 1025
D + EG D G +C+ D+ T T+ V I K+
Sbjct: 685 ESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVYPSGKVYV 744
Query: 1026 FEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEG 1085
V+ + V +L E+ A+V W +DGE + +K +R+L + + D G
Sbjct: 745 AAVRLERV-VLTCELCRPWAEVRWTKDGEEVVESPALL-LQKEDTVRRLVLPAVQLEDSG 802
Query: 1086 EYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEI--ELTKGDALVRWFKDG 1143
EY C + DES + VTV E P II + + EL++ DA VRW+KDG
Sbjct: 803 EYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAPVRWYKDG 862
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL--R 1201
E++ S + L DG + +L + +D GE+ C+ G+ +TV EP + F
Sbjct: 863 LEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTEPPVQFLALET 922
Query: 1202 LPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTED 1261
P + V L+ E+ V W +++ E L ++ +R L I+
Sbjct: 923 TPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPA 982
Query: 1262 DQCEYTCVLLDAKSTTKLK--VEVVEFPPKIVDYE-REYRIKR--GSDVTLLV 1309
YTC A L V+V E P ++V E + R++ G D+ L+V
Sbjct: 983 HAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVV 1035
Score = 111 bits (266), Expect = 3e-23
Identities = 139/620 (22%), Positives = 240/620 (38%), Gaps = 41/620 (6%)
Query: 729 TGEKEPPQVIEPLK--SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSD 783
T ++ P ++ P S+ E V+L+ ++ P TW K+ + V+ L K D
Sbjct: 545 TIQESPVHILSPQDKVSLTFTTSERVVLTCELSRVDFPA-TWYKDGQKVEESELLVVKMD 603
Query: 784 GDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEIT 843
G H + IL KV+D G + + +EG++ V TV++P +P + F
Sbjct: 604 GRKHRL-ILPEAKVQDSGEFECR---TEGVSAFFGV-TVQDPPVHIVDPREHV--FVHAI 656
Query: 844 VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
E + L V R P + WY++ + + S+ + +G + LV+ D G+
Sbjct: 657 TSE--CVMLACEVDREDAP-VRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPS-DGGE 712
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEG-KTVILECQTSHT-VSTKWY 961
++CVA + + VTI V K Y + V+L C+ +W
Sbjct: 713 FQCVAGDECAYFT----VTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWT 768
Query: 962 HNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIR 1021
+ +E+ + +E D G C + D+ S + V E I
Sbjct: 769 KDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDESASFTVTVTEPPVRIIY 828
Query: 1022 KLQDFEV--KEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNT 1079
+ + + +L E++ E A V W +DG ++ + E+ G +L +
Sbjct: 829 PRDEVTLIAVTLECVVLMCELSREDAPVRWYKDGLEVE-ESEALVLERDGPRCRLVLPAA 887
Query: 1080 SVHDEGEYSCILRDESCTAEVTVVELPPEII---TRLQNQKVNKGNKATFEIELTKGDAL 1136
D GE+ C D+S VTV E P + + T V G EL++ A
Sbjct: 888 QPEDGGEFVCDAGDDSAFFTVTVTEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP 947
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILT----VE 1192
V W +G +Q ++L +G ++ L I AG Y+C+ G + L+ V
Sbjct: 948 VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVA 1007
Query: 1193 EPSINFTLRLPEFILVPANT--DAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKK 1250
EP + V + D L V + V WYK + + L +
Sbjct: 1008 EPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGAR 1067
Query: 1251 RTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP--PKIVDYEREYRIKRGSDVTLL 1308
+ L ++ D EY C DA +++ + VE P K+V + G D T
Sbjct: 1068 QVLRVQGARSGDAGEYLC---DAPQDSRIFLVSVEEPLLVKLVSDLTPLTVHEGDDATFR 1124
Query: 1309 VDYQAFPQPNDEWIVNSKII 1328
+ P + W+ N ++
Sbjct: 1125 CEVSP-PDADVTWLRNGAVV 1143
Score = 104 bits (249), Expect = 4e-21
Identities = 209/1033 (20%), Positives = 390/1033 (37%), Gaps = 101/1033 (9%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP--------QVIEPL----K 742
L+I + G Y A N G A +L++ + PP V+EPL K
Sbjct: 30 LRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPK 89
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-----SDGDTHSITILKPKKV 797
+ V +G+ V+G P P I W +P+ LP + D D + + +
Sbjct: 90 TFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPL--LPDRRRLMYRDRDGGFVLKVLYCQA 147
Query: 798 KDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
KD G+Y A NS G ++ + V+EP P Q++ +E G L +V
Sbjct: 148 KDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRP------LQDVEGREHGIAVLECKVP 201
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
+ +P+ W+R ++ + P Q +G L+I + ++ D G Y C G+
Sbjct: 202 NSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKAD-DDGIYLC---EMRGRVRT 256
Query: 918 GARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREII 976
A VT+ K +K L + + EG+ +L +T V +W + +E+ +
Sbjct: 257 VANVTV---KGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQS--- 310
Query: 977 QEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVK--ETIPEFIRKLQDFEVKEKDVA 1034
G D G + + + T+T+L VK + P L + K+
Sbjct: 311 SSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTV 370
Query: 1035 IL---EVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS-- 1088
+L E ET + ER + + EK G + + V EG+Y
Sbjct: 371 LLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVE---VPGDCVPSEGDYRFR 427
Query: 1089 -CILRDESCTAEVTV---VELPP--EIITRLQNQKVNKGNKATFEIELTKGDALVRWFKD 1142
C + + V L P ++ L++ +V G A F ++L+ WF +
Sbjct: 428 ICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLST-IIQGTWFLN 486
Query: 1143 GSEIQFSN----------HIQLTIDGKKQKLKIYDCDLDDAGE---YSCEVGNSKCTAIL 1189
G E++ + ++ G + +L ++ D+G +SC + +A L
Sbjct: 487 GEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCP--GVQDSAAL 544
Query: 1190 TVEEPSINFTLRLPEFILVPANTD-AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDV 1248
T++E ++ + L ++ LT E+ TWYK +E++E + D
Sbjct: 545 TIQESPVHILSPQDKVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDG 604
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRG--SDVT 1306
+K LI+ + D E+ C + V V + P IVD RE+ S+
Sbjct: 605 RKHRLILPEAKVQDSGEFECRTEGVSAF--FGVTVQDPPVHIVD-PREHVFVHAITSECV 661
Query: 1307 LLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNC 1366
+L W + + +++ + L + + +D G ++ + C
Sbjct: 662 MLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDEC 721
Query: 1367 GHADVEMNVTILDKPS----PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE- 1421
+ VTI D S P GK + + + + + + + + +E
Sbjct: 722 AY----FTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAE---VRWTKDGEEV 774
Query: 1422 IDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQS 1481
+++ + K T + + ++ S + + E+D AS T + +I
Sbjct: 775 VESPALLLQKEDTVRRLVLPAVQLEDSGEY----LCEIDDESASFTVTVTE--PPVRIIY 828
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXX 1541
P E L +T E + L C P V WY+DG +++ ++A R
Sbjct: 829 PRDEVTLIAVTL---ECVVLMCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVL 884
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV--GDEWLVTAVIEGI 1599
D G+ V + + PV ++ E V G+ +++ +
Sbjct: 885 PAAQPEDGGEFVCDAGDDSAFFTVTVTEPPVQFLALETTPSPLCVAPGEPVVLSCELSRA 944
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
P V+W NG ++ + + + V+ I+ +H+ YT ++ G S+ T
Sbjct: 945 GAP-VVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFT 1003
Query: 1660 LKVYDKPSKPEGP 1672
++V + P + P
Sbjct: 1004 VQVAEPPVRVVAP 1016
Score = 86.6 bits (205), Expect = 9e-16
Identities = 85/333 (25%), Positives = 139/333 (41%), Gaps = 31/333 (9%)
Query: 884 DGENIELVITNVDSEI-DSGDYKCVASNSAGKSSHGARVTI-----------DVEKVTFV 931
DG L + + + + DSG Y C A N+ G + GA + + D V
Sbjct: 22 DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 81
Query: 932 KHLQ---KSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXX 986
+ L+ K++ EGK C +W+ + + D R ++ R
Sbjct: 82 EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP-DRRRLMYRDRDGGFVL 140
Query: 987 XXXX--XXDVGVIKCIVKDQETSTM----LVVKETIPEFIRKLQDFEVKEKDVAILEVEI 1040
D G+ C ++ T+ L VKE F R LQD E +E +A+LE ++
Sbjct: 141 KVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLECKV 200
Query: 1041 NSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
+ W R+ + + P + KY+ + G +R+L I D+G Y C +R T
Sbjct: 201 PNSRIPTAWFREDQRLLPCR-KYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVAN 259
Query: 1101 TVVELPPEIITRLQNQ-KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGK 1159
V+ P I+ RL + V +G A +E + RW +DG E+ I + G
Sbjct: 260 VTVKGP--ILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPV---ICQSSSGH 314
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
L + +DAGE + +GNS+ T +L V+
Sbjct: 315 MHALVLPGVTREDAGEVTFSLGNSRTTTLLRVK 347
Score = 75.8 bits (178), Expect = 2e-12
Identities = 76/331 (22%), Positives = 128/331 (38%), Gaps = 17/331 (5%)
Query: 783 DGDTHSITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE-----NAEPPLFI 836
DG S+ + + ++ D GVY A N+ G A+ A++ V +P E + P +
Sbjct: 22 DGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVV 81
Query: 837 NRFQ----EITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVI 892
+ V E K V P P I W+ + P D + ++
Sbjct: 82 EPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLK 141
Query: 893 TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT 952
D G Y C A NSAG++ ++ + ++ F + LQ E E +LEC+
Sbjct: 142 VLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQ-DVEGREHGIAVLECKV 200
Query: 953 SHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLV 1011
++ + T W+ + + E I+EG D G+ C ++ + T+
Sbjct: 201 PNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGR-VRTVAN 259
Query: 1012 VKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHI 1071
V P R + +V E + A+L VE + W RDGE + GH+
Sbjct: 260 VTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQ----SSSGHM 315
Query: 1072 RKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
L + + D GE + L + T + V
Sbjct: 316 HALVLPGVTREDAGEVTFSLGNSRTTTLLRV 346
Score = 75.4 bits (177), Expect = 2e-12
Identities = 128/619 (20%), Positives = 231/619 (37%), Gaps = 51/619 (8%)
Query: 1118 VNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLKIYDCDLDDAGE 1175
VN+G A F + K + + W +G + + D LK+ C D G
Sbjct: 93 VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGL 152
Query: 1176 YSCEVGNSKCTAI----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYK 1231
Y C NS + L V+EP + FT L + + + A L ++P+ + W++
Sbjct: 153 YVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQD-VEGREHGIAVLECKVPNSRIPTAWFR 211
Query: 1232 KKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
+ + K+ I + R LII + DD Y C + + + V P +
Sbjct: 212 EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRTVANVTVKGPILK 268
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
R+ + G + LLV+ W S+ ++ S +L + V
Sbjct: 269 RLPRKLDVLEGENAVLLVETLE-AGVEGRW---SRDGEELPVICQSSSGHMHALVLPGVT 324
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI---DSSSINICWDEPENTG 1408
DAG L N+ + V + K SPPG P + E+ +++ + W PE
Sbjct: 325 REDAGEVTFSLGNS--RTTTLLRVKCV-KHSPPGPPILAEMFKGHKNTVLLTWKPPEPAP 381
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKNITKT---QTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
+ IY + E QE+ + +WI +I K + + + YRFR V+ S
Sbjct: 382 ETPFIYRL-ERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 440
Query: 1466 ETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
++ ++ + L+++ ED + + Q TW+ +G++LK+
Sbjct: 441 VFHGSAHLVPTARLVAG-----LEDVQVYDGEDAVFSLDLSTIIQG--TWFLNGEELKSN 493
Query: 1526 KATYE---NRXXXXXXXXXXXXXXXYKCIAFNDHGE--------VETSCVVGIQQKPVIT 1574
+ + + D G V+ S + IQ+ PV
Sbjct: 494 EPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHI 553
Query: 1575 ISNED-IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
+S +D + + ++T + + P WYK+G K+E + + + + +
Sbjct: 554 LSPQDKVSLTFTTSERVVLTCELSRVDFPAT-WYKDGQKVEESELLVVKMDGRKHRLILP 612
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP---SKPEGPVIMREISRESVTIEWKPP 1690
E K S ++ T G S+ + V D P P V + I+ E V + +
Sbjct: 613 EAKVQDSGEF---ECRTEGVSAF-FGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVD 668
Query: 1691 LDDGGLELTKYAIEKHEPD 1709
+D + K E E D
Sbjct: 669 REDAPVRWYKDGQEVEESD 687
Score = 58.4 bits (135), Expect = 3e-07
Identities = 61/253 (24%), Positives = 105/253 (41%), Gaps = 30/253 (11%)
Query: 577 DAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTF 636
D+G + C A+NA G A + L V P ++ A ++E +
Sbjct: 39 DSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPD----------EAPAPVVEPLKCA- 87
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
PK +V+EG C ++ PEP+I W ++G ++PD + + D VLK
Sbjct: 88 ---PKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGF---VLK 141
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP-QVIEPLKSMIVRQGESVILS 755
+ + G Y A N G+ + L + KEP + PL+ + R+ +L
Sbjct: 142 VLYCQAKDRGLYVCAARNSAGQTLSAVQLHV----KEPRLRFTRPLQDVEGREHGIAVLE 197
Query: 756 AQVVGNPRPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
+V + PT W + ++ P + +G + I+ K D+G+Y + G
Sbjct: 198 CKVPNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRL-IIHRLKADDDGIYLCE---MRG 252
Query: 813 IAETSAVITVEEP 825
T A +TV+ P
Sbjct: 253 RVRTVANVTVKGP 265
Score = 56.0 bits (129), Expect = 1e-06
Identities = 35/112 (31%), Positives = 53/112 (47%), Gaps = 5/112 (4%)
Query: 496 PVFEKPTSEEQSMAPIFVEKLR--PKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIK 551
P P +++ AP+ VE L+ PK +G +F C V G P P+I W + +
Sbjct: 65 PPESPPADPDEAPAPV-VEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLL 123
Query: 552 PSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
P + MY D D L + +D G + C A+N+AG S +L V+ P
Sbjct: 124 PDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEP 175
Score = 50.0 bits (114), Expect = 9e-05
Identities = 88/418 (21%), Positives = 155/418 (37%), Gaps = 34/418 (8%)
Query: 651 ILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTV 710
++L C L P ++ W GEE+V + + E + L + V+ G Y +
Sbjct: 752 VVLTCELCR-PWAEVRWTKDGEEVVESPALLLQKEDTVRR----LVLPAVQLEDSGEY-L 805
Query: 711 VAVNREGEASLPIVLKIKTGEKEPP-QVIEPLK--SMIVRQGESVILSAQVVGNPRPTIT 767
++ E AS + + EPP ++I P ++I E V+L ++ P +
Sbjct: 806 CEIDDES-ASFTVTVT------EPPVRIIYPRDEVTLIAVTLECVVLMCELSREDAP-VR 857
Query: 768 WCKNNKPVK---ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
W K+ V+ AL + DG + +L + +D G + A + SA TV
Sbjct: 858 WYKDGLEVEESEALVLERDGPRCRL-VLPAAQPEDGGEFVCDA------GDDSAFFTVTV 910
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
TE + + V + L ++R P + W N + E + + +
Sbjct: 911 -TEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNGRPVQEGEGLELHAE 968
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV--KHLQKSYETEE 942
G L I +G Y C + + G S V + V V + Q +
Sbjct: 969 GPRRVLCI-QAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTP 1027
Query: 943 GKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
G + L S +WY + + ++ ++ Q G D G C
Sbjct: 1028 GGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA 1087
Query: 1002 KDQETSTMLVVKETI-PEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKP 1058
++ V+E + + + L V E D A E++ ADV W R+G ++ P
Sbjct: 1088 PQDSRIFLVSVEEPLLVKLVSDLTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTP 1145
Score = 42.7 bits (96), Expect = 0.014
Identities = 44/237 (18%), Positives = 87/237 (36%), Gaps = 9/237 (3%)
Query: 1461 ISDASETTEYYKV-IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
+ DA + + ++ V + E +Q +E + P E + L+C P V W +G
Sbjct: 896 VCDAGDDSAFFTVTVTEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAP-VVWSHNG 954
Query: 1520 KKLKTAKATYEN----RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI 1575
+ ++ + + R Y C + G S V + + PV +
Sbjct: 955 RPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVV 1014
Query: 1576 SNE--DIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
+ E + + G + + + G P V WYK+G +L + + V+R++
Sbjct: 1015 APEAAQTRVRSTPGGDLELVVHLSG-PGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQ 1073
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPP 1690
+ + +Y +A + V V + K P+ + E + E PP
Sbjct: 1074 GARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSDLTPLTVHEGDDATFRCEVSPP 1130
>AY339601-1|AAQ02673.1| 1914|Homo sapiens long myosin light chain
kinase protein.
Length = 1914
Score = 136 bits (328), Expect = 1e-30
Identities = 105/431 (24%), Positives = 182/431 (42%), Gaps = 52/431 (12%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
+ S P F K + + + TV+F C+V G P+P++ WF + ++ + Y+D
Sbjct: 408 QRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDA 467
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
L + + D+GT++C A NA G S + L VE
Sbjct: 468 GSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQVER--------------------- 506
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
++E + P+FS K V EG D +L+C + P P I WL G+ I + A
Sbjct: 507 --LAVME-VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEA 563
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASL---------------PIVLKIK 728
+++H I + GTYT +A N G+ S +L +
Sbjct: 564 GVAELH-------IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVA 616
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGD 785
+ P ++ L + V G V ++ QV GNP P + W N ++ + G
Sbjct: 617 PSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGT 676
Query: 786 THSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVK 845
HS+ I + +D G YT +A NS G T AV+TV+EP + P FI++ + +T
Sbjct: 677 QHSLCI-QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP--HDGTQPWFISKPRSVTAS 733
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
++ + + +P P++ W R+ + + + E++ ++ +G Y+
Sbjct: 734 LGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYE 793
Query: 906 CVASNSAGKSS 916
+ N G+ S
Sbjct: 794 ILLKNRVGECS 804
Score = 128 bits (309), Expect = 2e-28
Identities = 96/366 (26%), Positives = 159/366 (43%), Gaps = 29/366 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE-NISVAIESDMHMYC 692
P F KP++Q V E + C + IP+P++AW +G + E +I V ++ H C
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQGE 750
+ + GTY+ A N +G+ S L+++ + P LK V +G+
Sbjct: 474 ----LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQ 529
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
+L V G P P ITW N +P++ + + + I + +D G YT AEN+
Sbjct: 530 DFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHI-QDALPEDHGTYTCLAENA 588
Query: 811 EGIAETSAVITVEEPTEEN----------AEP--PLFINRFQEITVKEKGTIKLVARVTR 858
G SA +TV E ++P P+F+ ++ V + + + +V+
Sbjct: 589 LGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSG 648
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
NP P + W N I SE G L I V E D+G Y C A NSAG+
Sbjct: 649 NPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPE-DTGTYTCEAWNSAGEVRTQ 707
Query: 919 ARVTI----DVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEI-SGMD 971
A +T+ D + F+ +S G++V++ C + + W + K +
Sbjct: 708 AVLTVQEPHDGTQPWFISK-PRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG 766
Query: 972 HREIIQ 977
H E++Q
Sbjct: 767 HFEVLQ 772
Score = 105 bits (251), Expect = 2e-21
Identities = 73/246 (29%), Positives = 105/246 (42%), Gaps = 12/246 (4%)
Query: 487 KLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
K + +D V P +E AP F+ R +G+T +FE +V GYP PQ+TW R
Sbjct: 14 KTSLSVDPSRVDSMPLTE----APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRN 69
Query: 547 TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I F + +LVI V ED G +TC A N +G T EL VE +
Sbjct: 70 GQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAK 129
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGI----PPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ V + I PP F+ K V EG C++ P+
Sbjct: 130 QLGQPVVSKTLGDRFSASAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQ 189
Query: 663 PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLP 722
P + WL + P +SV+ ++ M VL+I V + G YT + VN G+AS+
Sbjct: 190 PQVTWLKGNVPLQPSARVSVSEKNGM----QVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 723 IVLKIK 728
L I+
Sbjct: 246 AELSIQ 251
Score = 96.3 bits (229), Expect = 1e-18
Identities = 53/200 (26%), Positives = 90/200 (45%), Gaps = 1/200 (0%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP+I+ + + +++ G V L W+ K I++ +H K + LT
Sbjct: 1237 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLT 1296
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDEPE 1405
I G Y L +EN G ++N+T++DKP PP G P +I SSS+ + W
Sbjct: 1297 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1356
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G S + Y +E + W + T ++Q+L + Y+FR A+N S+ S
Sbjct: 1357 YDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPS 1416
Query: 1466 ETTEYYKVIKETKIQSPTVE 1485
+ +E V ++ + VE
Sbjct: 1417 QESELTTVGEKPEEPKDEVE 1436
Score = 95.5 bits (227), Expect = 2e-18
Identities = 69/241 (28%), Positives = 109/241 (45%), Gaps = 30/241 (12%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P + + APIF++ L DGS V QV G P P++ W I+ S+DF +
Sbjct: 614 PVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH-FE 672
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
+L I+EVFPED GT+TC A N+AG + L V+ P H
Sbjct: 673 QRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP---H------------- 716
Query: 621 XXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI 680
+G P F KP++ G +L+ C + P P + WL G+ + D
Sbjct: 717 ---------DGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGH 767
Query: 681 SVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK-TGEKEPPQVIE 739
++++ ++ VLK V+ + G Y ++ NR GE S + L ++ + + P+ E
Sbjct: 768 FEVLQNE-DVFTLVLK--KVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGRE 824
Query: 740 P 740
P
Sbjct: 825 P 825
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 1784 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 1843
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 1844 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1900
Score = 81.4 bits (192), Expect = 3e-14
Identities = 51/176 (28%), Positives = 79/176 (44%), Gaps = 3/176 (1%)
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
QK + G+ + + G P W K +++ + + E S + I ++ H
Sbjct: 1247 QKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCG 1306
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
YT+ N G+ +V L V DKP P G +I S+T+ W DGG + Y
Sbjct: 1307 CYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 1366
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESE 1756
+IE + N W ++A ++ +Q L + EY FRV A N G SE + ESE
Sbjct: 1367 SIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 1420
Score = 74.9 bits (176), Expect = 3e-12
Identities = 51/202 (25%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXX 1539
+P+ LK+ +D L C G P P++TW +G+ ++ A++T E
Sbjct: 513 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQD 572
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQ----------------KPVITISNEDIKQ- 1582
Y C+A N G+V S V + + KP I + +
Sbjct: 573 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 632
Query: 1583 KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSK 1642
K G + +T + G PPPEVIW NGN+++ ++++ + + I+E+ +
Sbjct: 633 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGT 692
Query: 1643 YTIEASNTAGTSSVEVTLKVYD 1664
YT EA N+AG + L V +
Sbjct: 693 YTCEAWNSAGEVRTQAVLTVQE 714
Score = 69.7 bits (163), Expect = 1e-10
Identities = 85/402 (21%), Positives = 161/402 (40%), Gaps = 45/402 (11%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P+F K Q EVKE E++ +V W +G ++ ++ + + L
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 1076 IRNTSVHDEGEYSCILRDE----SCT-----AEVTVVELPPEIITRLQNQKVNKGNKATF 1126
+ D G YSC + SC+ + V+E+ P + L++ V +G
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1127 EIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EV 1180
+ + +G + R W +G IQ++ T + +L I D +D G Y+C +
Sbjct: 534 QCSV-RGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCLAENAL 589
Query: 1181 GNSKCTAILTVEE-----------------PSINFTLRLPEFILVPANTDAYLTVEIP-D 1222
G C+A +TV E P+ L+ + V + +TV++ +
Sbjct: 590 GQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGN 649
Query: 1223 ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLK-V 1281
+V W + I+++E F + +L I++ +D YTC ++ + + V
Sbjct: 650 PPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAV 709
Query: 1282 EVVEFP-----PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII-KKCKHTK 1335
V+ P P + R G V + P P W+ + K + K H +
Sbjct: 710 LTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFE 769
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ +L +KKV+ AG Y++ L+N G ++++ +
Sbjct: 770 VLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLML 811
Score = 66.5 bits (155), Expect = 1e-09
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE Q AP F +KL+ H +G + +CQV P I W +K ++ F + +
Sbjct: 1091 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQE 1149
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDH 607
++ ++ I + PED G + CVAKN AG A + ++ V +AP S++
Sbjct: 1150 GSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASEN 1195
Score = 65.7 bits (153), Expect = 2e-09
Identities = 47/213 (22%), Positives = 91/213 (42%), Gaps = 8/213 (3%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S +EY + +K +P + L ++ + +T G P P+V W +G +++
Sbjct: 605 SSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQ 664
Query: 1524 TAK-ATYENRXXXXX---XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT---IS 1576
++ +E R Y C A+N GEV T V+ +Q+ T
Sbjct: 665 ESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFI 724
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKEL 1635
++ +G L++ I G P P V W ++G L D + + E + +K++
Sbjct: 725 SKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKV 784
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ H+ +Y I N G S +V+L + + ++
Sbjct: 785 QPWHAGQYEILLKNRVGECSCQVSLMLQNSSAR 817
Score = 64.9 bits (151), Expect = 3e-09
Identities = 91/429 (21%), Positives = 168/429 (39%), Gaps = 47/429 (10%)
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
S+ + +A + + ++ P F ++ Q VKE T+K V+ P P + W+
Sbjct: 391 SQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE 450
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ E + ++ + DSG Y C ASN+ G+ S T+ VE++
Sbjct: 451 GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQVS--CSWTLQVERLA 508
Query: 930 FVK------HLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEI--------SGMDHR 973
++ + K EG+ +L+C T + W N + I +G+
Sbjct: 509 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAEL 568
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETST----MLVV---KETIPEFIRK 1022
I +G + C V ++++S +L V K T P F++
Sbjct: 569 HIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQG 628
Query: 1023 LQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSV 1081
L D +V + + V+++ + +V+W +G I+ ++ + FE+RG L I+
Sbjct: 629 LSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED-FHFEQRGTQHSLCIQEVFP 687
Query: 1082 HDEGEYSCIL---RDESCTAEVTVVELP-----PEIITRLQNQKVNKGNKATFEIELTKG 1133
D G Y+C E T V V+ P P I++ ++ + G + G
Sbjct: 688 EDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIA-G 746
Query: 1134 DAL--VRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCT 1186
D V W +DG + + + H ++ + L + AG+Y VG C
Sbjct: 747 DPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQ 806
Query: 1187 AILTVEEPS 1195
L ++ S
Sbjct: 807 VSLMLQNSS 815
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 33/222 (14%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHS 788
E P I P +++ +++G + +V G P P +TW +N +P+ + L T S
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 789 ITILKPKKVKDEGVYTLKAENS------------EG----------IAET-----SAVIT 821
+ I + +D G YT +A N EG +++T SA
Sbjct: 91 LVIHAVHE-EDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAV 149
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
P+ PP F + + VKE + ++T P P +TW + N + PS ++
Sbjct: 150 ETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSV 209
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ L I V+ + D G Y C+ N +GK+S A ++I
Sbjct: 210 SEKNGMQVLEIHGVNQD-DVGVYTCLVVNGSGKASMSAELSI 250
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/203 (19%), Positives = 85/203 (41%), Gaps = 12/203 (5%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT---YENRXXXX-- 1536
P E ++ + N+ ++ C G+P+P+V W+ +G ++ + + YE+
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI--SNEDIKQKHKV--GDEWLV 1592
Y C A N G+V S + +++ V+ + S + + V G ++++
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ G P P + W NG ++ + T + + + I++ YT A N G
Sbjct: 534 QCSVRGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCLAENALG 590
Query: 1653 TSSVEVTLKVYDKPSKPEGPVIM 1675
S + V++K S + ++
Sbjct: 591 QVSCSAWVTVHEKKSSRKSEYLL 613
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/200 (24%), Positives = 87/200 (43%), Gaps = 12/200 (6%)
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
+KV + + + + E+C + ++ +N +G +A V T +D P
Sbjct: 1284 MKVENSENGSKLTILAARQEHCG-CYTLLVENKLGSRQAQ-----VNLTVVDKPDPPAGT 1337
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSIN 1832
I + S+ ++W+ S +GGS + Y +EI K WK +Q L +
Sbjct: 1338 PCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD 1397
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEPES 1891
Y+FR+ A N GTS P + T+G+ P +P++ V VS+ + + +
Sbjct: 1398 HEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPKDEVEVSDDDEKEPEVDYRTVTI 1454
Query: 1892 NGGSPITN-YIIEFKTVKGK 1910
N +++ Y IE + GK
Sbjct: 1455 NTEQKVSDFYDIEERLGSGK 1474
Score = 58.0 bits (134), Expect = 3e-07
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 1331 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 1388
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
FN++DL +H Y R+ A N G SEP + E V GE EEP ++ EV
Sbjct: 1389 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTV--GE---KPEEPKDEVEV 1437
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 5/132 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + L+ + V +G+ ++L QV +P TI W N K +K + +G S++I
Sbjct: 1098 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1157
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTI 850
K +D G+Y A+N G AE S +TV++ P EN + P +R + ++
Sbjct: 1158 EKALP-EDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGT 1216
Query: 851 KLVARVTRNPVP 862
+ A V + P P
Sbjct: 1217 ESDATVKKKPAP 1228
Score = 55.2 bits (127), Expect = 2e-06
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 43/246 (17%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI--------- 680
+G P F +K + +V EG +LL+C++ + P I W G+ + + I
Sbjct: 1094 QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLC 1153
Query: 681 SVAIES----DMHMY------------CSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
SV+IE D +Y CS + E T +R ++SLP V
Sbjct: 1154 SVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPV 1213
Query: 725 L--------KIKTGEKEPP------QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK 770
L K K K PP Q+I+ + VR GESV L +V G T TW K
Sbjct: 1214 LGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMK 1273
Query: 771 NNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
K ++ + ++ + +TIL ++ + G YTL EN G + +TV + +
Sbjct: 1274 FRKQIQESEHMKVENSENGSKLTILAARQ-EHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1332
Query: 828 ENAEPP 833
A P
Sbjct: 1333 PPAGTP 1338
Score = 54.4 bits (125), Expect = 4e-06
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
PP+ L ++V++G+ S ++ G P+P +TW K N P++ S + + + +L+
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 219
Query: 794 PKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
V D GVYT N G A SA ++++
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQ 251
Score = 54.0 bits (124), Expect = 6e-06
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E+ +E P F + Q++ V E + L +V+ +P +I W N + + ++ I +
Sbjct: 1088 EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILS 1147
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
+G + I E D G YKCVA N AG++ +VT+D
Sbjct: 1148 QEGSLCSVSIEKALPE-DRGLYKCVAKNDAGQAECSCQVTVD 1188
Score = 52.8 bits (121), Expect = 1e-05
Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P F +KLQD V E +L+ +++S+ A ++W +G+ +K K + G +
Sbjct: 1096 TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQEGSLCS 1154
Query: 1074 LYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
+ I D G Y C+ ++++ C+ +VTV + P T+ K + + +
Sbjct: 1155 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVL 1214
Query: 1130 LTKGDALVR 1138
T+ DA V+
Sbjct: 1215 GTESDATVK 1223
Score = 51.6 bits (118), Expect = 3e-05
Identities = 68/322 (21%), Positives = 122/322 (37%), Gaps = 29/322 (9%)
Query: 1226 DVTWYKKKSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK----LK 1280
+V W+ + + + E + D L + K D Y+C +A+ L+
Sbjct: 444 EVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQ 503
Query: 1281 VE---VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
VE V+E P ++ + G D L + P P W++N + I ++ + +
Sbjct: 504 VERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI---QYARST 560
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS- 1396
++ A L I+ D G Y EN G VT+ +K S +L + S
Sbjct: 561 CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP 620
Query: 1397 ---INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRA 1453
I + + + + V+ E I + N + Q S ++ +
Sbjct: 621 TAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQES-EDFHFEQRGTQHS 679
Query: 1454 YAVNEVDISD-ASETTEYYKVIKETKIQSP-TVEKP-----------LKNITTEPNEDIE 1500
+ EV D + T E + E + Q+ TV++P +++T + +
Sbjct: 680 LCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL 739
Query: 1501 LTCIFGGVPQPKVTWYRDGKKL 1522
++C G P P V W RDGK L
Sbjct: 740 ISCAIAGDPFPTVHWLRDGKAL 761
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 1807 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 1864
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 1865 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 1904
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+NLK+ S + N+V+ T + E++ +P ++ L+++ + +
Sbjct: 1057 ENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLL 1116
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX----XXXYKCIAFNDH 1556
L C P + W +GK LKT K ++ YKC+A ND
Sbjct: 1117 LQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDA 1176
Query: 1557 GEVETSCVVGIQQKP 1571
G+ E SC V + P
Sbjct: 1177 GQAECSCQVTVDDAP 1191
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 42/94 (44%)
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
E P FI + + +KE T K RV P P +TW+RN + I+ +
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
++ + E D G Y C A+N +G +T++
Sbjct: 91 LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVE 124
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 1781 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 1840
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 1841 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 1899
Query: 924 D 924
+
Sbjct: 1900 E 1900
Score = 45.6 bits (103), Expect = 0.002
Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
E PP+ T+L V +G F ++T + V W K +Q S + ++ Q
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQV 217
Query: 1163 LKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
L+I+ + DD G Y+C V N A ++ E
Sbjct: 218 LEIHGVNQDDVGVYTCLVVNGSGKASMSAE 247
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 4/101 (3%)
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKD 1934
S+ S S+TL W +GGS + +Y IE K+W ++ T + ++++
Sbjct: 1341 SDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFN--VQDLLPDH 1398
Query: 1935 EIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
E FR+ A N G S P SQ L P P +E+
Sbjct: 1399 EYKFRVRAINVYGTSEP--SQESELTTVGEKPEEPKDEVEV 1437
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/88 (26%), Positives = 40/88 (45%)
Query: 1295 REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
++ + G + L + P W +N K +K K S + S++I+K D
Sbjct: 1105 QDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPED 1164
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPS 1382
G+YK +N+ G A+ VT+ D P+
Sbjct: 1165 RGLYKCVAKNDAGQAECSCQVTVDDAPA 1192
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 1809 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1868
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 1869 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1900
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 4/100 (4%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P+V W++NG + + + + + T + I + KYT EA+N +G
Sbjct: 56 VRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGAR 115
Query: 1655 SVEVTLKVYDKPSKPEG-PVIMREI-SRESVT-IEWKPPL 1691
V V L V +K G PV+ + + R S + +E +P +
Sbjct: 116 QVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAVETRPSI 155
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 1832 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 1891
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 1892 TCTAELIV 1899
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 1809 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1868
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 1869 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 1908
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/103 (22%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +LQ+ V +G K + +++ A + W +G ++ + I L+ +G + I
Sbjct: 1098 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1157
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
+D G Y C + G ++C+ +TV++ + + PE
Sbjct: 1158 EKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 1200
Score = 34.7 bits (76), Expect = 3.7
Identities = 19/78 (24%), Positives = 32/78 (41%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G + I G P P+V W K L+ +++ K V+ I + + YT
Sbjct: 173 KEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYT 232
Query: 1645 IEASNTAGTSSVEVTLKV 1662
N +G +S+ L +
Sbjct: 233 CLVVNGSGKASMSAELSI 250
Score = 33.9 bits (74), Expect = 6.4
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + PP +IW NG L+ K ++ + + I++ Y
Sbjct: 1112 GKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCV 1171
Query: 1647 ASNTAGTSSVEVTLKVYDKPS 1667
A N AG + + V D P+
Sbjct: 1172 AKNDAGQAECSCQVTVDDAPA 1192
Score = 33.5 bits (73), Expect = 8.5
Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 12/128 (9%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALV-RWFKDGSEIQFSNHIQLTIDGKKQKL 1163
+PP+II ++QKV G ++T + W K +IQ S H+++ KL
Sbjct: 1236 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKL 1295
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAYLTVEIPD 1222
I + G Y+ V N L + +N T + P+ PA T +I
Sbjct: 1296 TILAARQEHCGCYTLLVENK-----LGSRQAQVNLTVVDKPD---PPAGTPC--ASDIRS 1345
Query: 1223 ETLDVTWY 1230
+L ++WY
Sbjct: 1346 SSLTLSWY 1353
>U48959-1|AAC18423.2| 1914|Homo sapiens myosin light chain kinase
protein.
Length = 1914
Score = 135 bits (327), Expect = 1e-30
Identities = 105/431 (24%), Positives = 182/431 (42%), Gaps = 52/431 (12%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
+ S P F K + + + TV+F C+V G P+P++ WF + ++ + Y+D
Sbjct: 408 QRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDA 467
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
L + + D+GT++C A NA G S + L VE
Sbjct: 468 GSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQVER--------------------- 506
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
++E + P+FS K V EG D +L+C + P P I WL G+ I + A
Sbjct: 507 --LAVME-VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEA 563
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASL---------------PIVLKIK 728
+++H I + GTYT +A N G+ S +L +
Sbjct: 564 GVAELH-------IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVA 616
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGD 785
+ P ++ L + V G V ++ QV GNP P + W N ++ + G
Sbjct: 617 PSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGT 676
Query: 786 THSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVK 845
HS+ I + +D G YT +A NS G T AV+TV+EP + P FI++ + +T
Sbjct: 677 QHSLWI-QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP--HDGTQPWFISKPRSVTAS 733
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
++ + + +P P++ W R+ + + + E++ ++ +G Y+
Sbjct: 734 LGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYE 793
Query: 906 CVASNSAGKSS 916
+ N G+ S
Sbjct: 794 ILLKNRVGECS 804
Score = 127 bits (307), Expect = 4e-28
Identities = 96/366 (26%), Positives = 159/366 (43%), Gaps = 29/366 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE-NISVAIESDMHMYC 692
P F KP++Q V E + C + IP+P++AW +G + E +I V ++ H C
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQGE 750
+ + GTY+ A N +G+ S L+++ + P LK V +G+
Sbjct: 474 ----LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQ 529
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
+L V G P P ITW N +P++ + + + I + +D G YT AEN+
Sbjct: 530 DFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHI-QDALPEDHGTYTCLAENA 588
Query: 811 EGIAETSAVITVEEPTEEN----------AEP--PLFINRFQEITVKEKGTIKLVARVTR 858
G SA +TV E ++P P+F+ ++ V + + + +V+
Sbjct: 589 LGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSG 648
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
NP P + W N I SE G L I V E D+G Y C A NSAG+
Sbjct: 649 NPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPE-DTGTYTCEAWNSAGEVRTQ 707
Query: 919 ARVTI----DVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEI-SGMD 971
A +T+ D + F+ +S G++V++ C + + W + K +
Sbjct: 708 AVLTVQEPHDGTQPWFISK-PRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG 766
Query: 972 HREIIQ 977
H E++Q
Sbjct: 767 HFEVLQ 772
Score = 105 bits (251), Expect = 2e-21
Identities = 73/246 (29%), Positives = 105/246 (42%), Gaps = 12/246 (4%)
Query: 487 KLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
K + +D V P +E AP F+ R +G+T +FE +V GYP PQ+TW R
Sbjct: 14 KTSLSVDPSRVDSMPLTE----APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRN 69
Query: 547 TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I F + +LVI V ED G +TC A N +G T EL VE +
Sbjct: 70 GQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAK 129
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGI----PPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ V + I PP F+ K V EG C++ P+
Sbjct: 130 QLGQPVVSKTLGDRFSASAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQ 189
Query: 663 PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLP 722
P + WL + P +SV+ ++ M VL+I V + G YT + VN G+AS+
Sbjct: 190 PQVTWLKGNVPLQPSARVSVSEKNGM----QVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 723 IVLKIK 728
L I+
Sbjct: 246 AELSIQ 251
Score = 96.3 bits (229), Expect = 1e-18
Identities = 53/200 (26%), Positives = 90/200 (45%), Gaps = 1/200 (0%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP+I+ + + +++ G V L W+ K I++ +H K + LT
Sbjct: 1237 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLT 1296
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDEPE 1405
I G Y L +EN G ++N+T++DKP PP G P +I SSS+ + W
Sbjct: 1297 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1356
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G S + Y +E + W + T ++Q+L + Y+FR A+N S+ S
Sbjct: 1357 YDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPS 1416
Query: 1466 ETTEYYKVIKETKIQSPTVE 1485
+ +E V ++ + VE
Sbjct: 1417 QESELTTVGEKPEEPKDEVE 1436
Score = 94.7 bits (225), Expect = 3e-18
Identities = 69/241 (28%), Positives = 109/241 (45%), Gaps = 30/241 (12%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P + + APIF++ L DGS V QV G P P++ W I+ S+DF +
Sbjct: 614 PVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH-FE 672
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
+L I+EVFPED GT+TC A N+AG + L V+ P H
Sbjct: 673 QRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP---H------------- 716
Query: 621 XXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI 680
+G P F KP++ G +L+ C + P P + WL G+ + D
Sbjct: 717 ---------DGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGH 767
Query: 681 SVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK-TGEKEPPQVIE 739
++++ ++ VLK V+ + G Y ++ NR GE S + L ++ + + P+ E
Sbjct: 768 FEVLQNE-DVFTLVLK--KVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGRE 824
Query: 740 P 740
P
Sbjct: 825 P 825
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 1784 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 1843
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 1844 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1900
Score = 81.4 bits (192), Expect = 3e-14
Identities = 51/176 (28%), Positives = 79/176 (44%), Gaps = 3/176 (1%)
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
QK + G+ + + G P W K +++ + + E S + I ++ H
Sbjct: 1247 QKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCG 1306
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
YT+ N G+ +V L V DKP P G +I S+T+ W DGG + Y
Sbjct: 1307 CYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 1366
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESE 1756
+IE + N W ++A ++ +Q L + EY FRV A N G SE + ESE
Sbjct: 1367 SIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 1420
Score = 74.9 bits (176), Expect = 3e-12
Identities = 51/202 (25%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXX 1539
+P+ LK+ +D L C G P P++TW +G+ ++ A++T E
Sbjct: 513 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQD 572
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQ----------------KPVITISNEDIKQ- 1582
Y C+A N G+V S V + + KP I + +
Sbjct: 573 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 632
Query: 1583 KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSK 1642
K G + +T + G PPPEVIW NGN+++ ++++ + + I+E+ +
Sbjct: 633 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPEDTGT 692
Query: 1643 YTIEASNTAGTSSVEVTLKVYD 1664
YT EA N+AG + L V +
Sbjct: 693 YTCEAWNSAGEVRTQAVLTVQE 714
Score = 68.9 bits (161), Expect = 2e-10
Identities = 85/402 (21%), Positives = 161/402 (40%), Gaps = 45/402 (11%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P+F K Q EVKE E++ +V W +G ++ ++ + + L
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 1076 IRNTSVHDEGEYSCILRDE----SCT-----AEVTVVELPPEIITRLQNQKVNKGNKATF 1126
+ D G YSC + SC+ + V+E+ P + L++ V +G
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1127 EIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EV 1180
+ + +G + R W +G IQ++ T + +L I D +D G Y+C +
Sbjct: 534 QCSV-RGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCLAENAL 589
Query: 1181 GNSKCTAILTVEE-----------------PSINFTLRLPEFILVPANTDAYLTVEIP-D 1222
G C+A +TV E P+ L+ + V + +TV++ +
Sbjct: 590 GQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGN 649
Query: 1223 ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLK-V 1281
+V W + I+++E F + +L I++ +D YTC ++ + + V
Sbjct: 650 PPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAV 709
Query: 1282 EVVEFP-----PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII-KKCKHTK 1335
V+ P P + R G V + P P W+ + K + K H +
Sbjct: 710 LTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFE 769
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ +L +KKV+ AG Y++ L+N G ++++ +
Sbjct: 770 VLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLML 811
Score = 66.5 bits (155), Expect = 1e-09
Identities = 91/429 (21%), Positives = 168/429 (39%), Gaps = 47/429 (10%)
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
S+ + +A + + ++ P F ++ Q VKE T+K V+ P P + W+
Sbjct: 391 SQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE 450
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ E + ++ + DSG Y C ASN+ G+ S T+ VE++
Sbjct: 451 GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQVS--CSWTLQVERLA 508
Query: 930 FVK------HLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEI--------SGMDHR 973
++ + K EG+ +L+C T + W N + I +G+
Sbjct: 509 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAEL 568
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETST----MLVV---KETIPEFIRK 1022
I +G + C V ++++S +L V K T P F++
Sbjct: 569 HIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQG 628
Query: 1023 LQDFEVKEKDVAILEVEINSETA-DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSV 1081
L D +V + + V+++ +V+W +G I+ ++ + FE+RG L+I+
Sbjct: 629 LSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED-FHFEQRGTQHSLWIQEVFP 687
Query: 1082 HDEGEYSCIL---RDESCTAEVTVVELP-----PEIITRLQNQKVNKGNKATFEIELTKG 1133
D G Y+C E T V V+ P P I++ ++ + G + G
Sbjct: 688 EDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIA-G 746
Query: 1134 DAL--VRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCT 1186
D V W +DG + + + H ++ + L + AG+Y VG C
Sbjct: 747 DPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQ 806
Query: 1187 AILTVEEPS 1195
L ++ S
Sbjct: 807 VSLMLQNSS 815
Score = 66.5 bits (155), Expect = 1e-09
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE Q AP F +KL+ H +G + +CQV P I W +K ++ F + +
Sbjct: 1091 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQE 1149
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDH 607
++ ++ I + PED G + CVAKN AG A + ++ V +AP S++
Sbjct: 1150 GSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASEN 1195
Score = 65.7 bits (153), Expect = 2e-09
Identities = 47/213 (22%), Positives = 91/213 (42%), Gaps = 8/213 (3%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S +EY + +K +P + L ++ + +T G P P+V W +G +++
Sbjct: 605 SSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQ 664
Query: 1524 TAK-ATYENRXXXXX---XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT---IS 1576
++ +E R Y C A+N GEV T V+ +Q+ T
Sbjct: 665 ESEDFHFEQRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFI 724
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKEL 1635
++ +G L++ I G P P V W ++G L D + + E + +K++
Sbjct: 725 SKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKV 784
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ H+ +Y I N G S +V+L + + ++
Sbjct: 785 QPWHAGQYEILLKNRVGECSCQVSLMLQNSSAR 817
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 33/222 (14%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHS 788
E P I P +++ +++G + +V G P P +TW +N +P+ + L T S
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 789 ITILKPKKVKDEGVYTLKAENS------------EG----------IAET-----SAVIT 821
+ I + +D G YT +A N EG +++T SA
Sbjct: 91 LVIHAVHE-EDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAV 149
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
P+ PP F + + VKE + ++T P P +TW + N + PS ++
Sbjct: 150 ETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSV 209
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ L I V+ + D G Y C+ N +GK+S A ++I
Sbjct: 210 SEKNGMQVLEIHGVNQD-DVGVYTCLVVNGSGKASMSAELSI 250
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/203 (19%), Positives = 85/203 (41%), Gaps = 12/203 (5%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT---YENRXXXX-- 1536
P E ++ + N+ ++ C G+P+P+V W+ +G ++ + + YE+
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI--SNEDIKQKHKV--GDEWLV 1592
Y C A N G+V S + +++ V+ + S + + V G ++++
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ G P P + W NG ++ + T + + + I++ YT A N G
Sbjct: 534 QCSVRGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCLAENALG 590
Query: 1653 TSSVEVTLKVYDKPSKPEGPVIM 1675
S + V++K S + ++
Sbjct: 591 QVSCSAWVTVHEKKSSRKSEYLL 613
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/200 (24%), Positives = 87/200 (43%), Gaps = 12/200 (6%)
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
+KV + + + + E+C + ++ +N +G +A V T +D P
Sbjct: 1284 MKVENSENGSKLTILAARQEHCG-CYTLLVENKLGSRQAQ-----VNLTVVDKPDPPAGT 1337
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSIN 1832
I + S+ ++W+ S +GGS + Y +EI K WK +Q L +
Sbjct: 1338 PCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD 1397
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEPES 1891
Y+FR+ A N GTS P + T+G+ P +P++ V VS+ + + +
Sbjct: 1398 HEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPKDEVEVSDDDEKEPEVDYRTVTI 1454
Query: 1892 NGGSPITN-YIIEFKTVKGK 1910
N +++ Y IE + GK
Sbjct: 1455 NTEQKVSDFYDIEERLGSGK 1474
Score = 58.0 bits (134), Expect = 3e-07
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 1331 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 1388
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
FN++DL +H Y R+ A N G SEP + E V GE EEP ++ EV
Sbjct: 1389 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTV--GE---KPEEPKDEVEV 1437
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 5/132 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + L+ + V +G+ ++L QV +P TI W N K +K + +G S++I
Sbjct: 1098 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1157
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTI 850
K +D G+Y A+N G AE S +TV++ P EN + P +R + ++
Sbjct: 1158 EKALP-EDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGT 1216
Query: 851 KLVARVTRNPVP 862
+ A V + P P
Sbjct: 1217 ESDATVKKKPAP 1228
Score = 55.2 bits (127), Expect = 2e-06
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 43/246 (17%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI--------- 680
+G P F +K + +V EG +LL+C++ + P I W G+ + + I
Sbjct: 1094 QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLC 1153
Query: 681 SVAIES----DMHMY------------CSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
SV+IE D +Y CS + E T +R ++SLP V
Sbjct: 1154 SVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPV 1213
Query: 725 L--------KIKTGEKEPP------QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK 770
L K K K PP Q+I+ + VR GESV L +V G T TW K
Sbjct: 1214 LGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMK 1273
Query: 771 NNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
K ++ + ++ + +TIL ++ + G YTL EN G + +TV + +
Sbjct: 1274 FRKQIQESEHMKVENSENGSKLTILAARQ-EHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1332
Query: 828 ENAEPP 833
A P
Sbjct: 1333 PPAGTP 1338
Score = 54.4 bits (125), Expect = 4e-06
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
PP+ L ++V++G+ S ++ G P+P +TW K N P++ S + + + +L+
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 219
Query: 794 PKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
V D GVYT N G A SA ++++
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQ 251
Score = 54.0 bits (124), Expect = 6e-06
Identities = 39/152 (25%), Positives = 69/152 (45%), Gaps = 7/152 (4%)
Query: 452 NQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNE-KIDKLPVFEKPTSEEQSMAP 510
++D+ + Q+ T+ W+ + D YT E + + ++P Q P
Sbjct: 666 SEDFHFEQRG-TQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ---P 721
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLV 569
F+ K R G +V C + G P P + W R A+ K + F++ ++D V TLV
Sbjct: 722 WFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNED-VFTLV 780
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+++V P AG + + KN G S L+++
Sbjct: 781 LKKVQPWHAGQYEILLKNRVGECSCQVSLMLQ 812
Score = 54.0 bits (124), Expect = 6e-06
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E+ +E P F + Q++ V E + L +V+ +P +I W N + + ++ I +
Sbjct: 1088 EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILS 1147
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
+G + I E D G YKCVA N AG++ +VT+D
Sbjct: 1148 QEGSLCSVSIEKALPE-DRGLYKCVAKNDAGQAECSCQVTVD 1188
Score = 52.8 bits (121), Expect = 1e-05
Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P F +KLQD V E +L+ +++S+ A ++W +G+ +K K + G +
Sbjct: 1096 TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQEGSLCS 1154
Query: 1074 LYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
+ I D G Y C+ ++++ C+ +VTV + P T+ K + + +
Sbjct: 1155 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVL 1214
Query: 1130 LTKGDALVR 1138
T+ DA V+
Sbjct: 1215 GTESDATVK 1223
Score = 50.4 bits (115), Expect = 7e-05
Identities = 68/322 (21%), Positives = 122/322 (37%), Gaps = 29/322 (9%)
Query: 1226 DVTWYKKKSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK----LK 1280
+V W+ + + + E + D L + K D Y+C +A+ L+
Sbjct: 444 EVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQ 503
Query: 1281 VE---VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
VE V+E P ++ + G D L + P P W++N + I ++ + +
Sbjct: 504 VERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI---QYARST 560
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS- 1396
++ A L I+ D G Y EN G VT+ +K S +L + S
Sbjct: 561 CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP 620
Query: 1397 ---INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRA 1453
I + + + + V+ E I + N + Q S ++ +
Sbjct: 621 TAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQES-EDFHFEQRGTQHS 679
Query: 1454 YAVNEVDISD-ASETTEYYKVIKETKIQSP-TVEKP-----------LKNITTEPNEDIE 1500
+ EV D + T E + E + Q+ TV++P +++T + +
Sbjct: 680 LWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL 739
Query: 1501 LTCIFGGVPQPKVTWYRDGKKL 1522
++C G P P V W RDGK L
Sbjct: 740 ISCAIAGDPFPTVHWLRDGKAL 761
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 1807 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 1864
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 1865 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 1904
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+NLK+ S + N+V+ T + E++ +P ++ L+++ + +
Sbjct: 1057 ENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLL 1116
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX----XXXYKCIAFNDH 1556
L C P + W +GK LKT K ++ YKC+A ND
Sbjct: 1117 LQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDA 1176
Query: 1557 GEVETSCVVGIQQKP 1571
G+ E SC V + P
Sbjct: 1177 GQAECSCQVTVDDAP 1191
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 42/94 (44%)
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
E P FI + + +KE T K RV P P +TW+RN + I+ +
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
++ + E D G Y C A+N +G +T++
Sbjct: 91 LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVE 124
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 1781 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 1840
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 1841 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 1899
Query: 924 D 924
+
Sbjct: 1900 E 1900
Score = 45.6 bits (103), Expect = 0.002
Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
E PP+ T+L V +G F ++T + V W K +Q S + ++ Q
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQV 217
Query: 1163 LKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
L+I+ + DD G Y+C V N A ++ E
Sbjct: 218 LEIHGVNQDDVGVYTCLVVNGSGKASMSAE 247
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 4/101 (3%)
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKD 1934
S+ S S+TL W +GGS + +Y IE K+W ++ T + ++++
Sbjct: 1341 SDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFN--VQDLLPDH 1398
Query: 1935 EIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
E FR+ A N G S P SQ L P P +E+
Sbjct: 1399 EYKFRVRAINVYGTSEP--SQESELTTVGEKPEEPKDEVEV 1437
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/88 (26%), Positives = 40/88 (45%)
Query: 1295 REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
++ + G + L + P W +N K +K K S + S++I+K D
Sbjct: 1105 QDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPED 1164
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPS 1382
G+YK +N+ G A+ VT+ D P+
Sbjct: 1165 RGLYKCVAKNDAGQAECSCQVTVDDAPA 1192
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 1809 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1868
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 1869 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1900
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 4/100 (4%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P+V W++NG + + + + + T + I + KYT EA+N +G
Sbjct: 56 VRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGAR 115
Query: 1655 SVEVTLKVYDKPSKPEG-PVIMREI-SRESVT-IEWKPPL 1691
V V L V +K G PV+ + + R S + +E +P +
Sbjct: 116 QVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAVETRPSI 155
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 1832 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 1891
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 1892 TCTAELIV 1899
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 1809 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1868
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 1869 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 1908
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/103 (22%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +LQ+ V +G K + +++ A + W +G ++ + I L+ +G + I
Sbjct: 1098 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1157
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
+D G Y C + G ++C+ +TV++ + + PE
Sbjct: 1158 EKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 1200
Score = 34.7 bits (76), Expect = 3.7
Identities = 19/78 (24%), Positives = 32/78 (41%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G + I G P P+V W K L+ +++ K V+ I + + YT
Sbjct: 173 KEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYT 232
Query: 1645 IEASNTAGTSSVEVTLKV 1662
N +G +S+ L +
Sbjct: 233 CLVVNGSGKASMSAELSI 250
Score = 33.9 bits (74), Expect = 6.4
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + PP +IW NG L+ K ++ + + I++ Y
Sbjct: 1112 GKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCV 1171
Query: 1647 ASNTAGTSSVEVTLKVYDKPS 1667
A N AG + + V D P+
Sbjct: 1172 AKNDAGQAECSCQVTVDDAPA 1192
Score = 33.5 bits (73), Expect = 8.5
Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 12/128 (9%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALV-RWFKDGSEIQFSNHIQLTIDGKKQKL 1163
+PP+II ++QKV G ++T + W K +IQ S H+++ KL
Sbjct: 1236 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKL 1295
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAYLTVEIPD 1222
I + G Y+ V N L + +N T + P+ PA T +I
Sbjct: 1296 TILAARQEHCGCYTLLVENK-----LGSRQAQVNLTVVDKPD---PPAGTPC--ASDIRS 1345
Query: 1223 ETLDVTWY 1230
+L ++WY
Sbjct: 1346 SSLTLSWY 1353
>AF069602-1|AAD15922.1| 1862|Homo sapiens myosin light chain kinase
isoform 3A protein.
Length = 1862
Score = 135 bits (327), Expect = 1e-30
Identities = 105/431 (24%), Positives = 182/431 (42%), Gaps = 52/431 (12%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
+ S P F K + + + TV+F C+V G P+P++ WF + ++ + Y+D
Sbjct: 408 QRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDA 467
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
L + + D+GT++C A NA G S + L VE
Sbjct: 468 GSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQVER--------------------- 506
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
++E + P+FS K V EG D +L+C + P P I WL G+ I + A
Sbjct: 507 --LAVME-VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEA 563
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASL---------------PIVLKIK 728
+++H I + GTYT +A N G+ S +L +
Sbjct: 564 GVAELH-------IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVA 616
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGD 785
+ P ++ L + V G V ++ QV GNP P + W N ++ + G
Sbjct: 617 PSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGT 676
Query: 786 THSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVK 845
HS+ I + +D G YT +A NS G T AV+TV+EP + P FI++ + +T
Sbjct: 677 QHSLWI-QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP--HDGTQPWFISKPRSVTAS 733
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
++ + + +P P++ W R+ + + + E++ ++ +G Y+
Sbjct: 734 LGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYE 793
Query: 906 CVASNSAGKSS 916
+ N G+ S
Sbjct: 794 ILLKNRVGECS 804
Score = 127 bits (307), Expect = 4e-28
Identities = 96/366 (26%), Positives = 159/366 (43%), Gaps = 29/366 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE-NISVAIESDMHMYC 692
P F KP++Q V E + C + IP+P++AW +G + E +I V ++ H C
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQGE 750
+ + GTY+ A N +G+ S L+++ + P LK V +G+
Sbjct: 474 ----LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQ 529
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
+L V G P P ITW N +P++ + + + I + +D G YT AEN+
Sbjct: 530 DFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHI-QDALPEDHGTYTCLAENA 588
Query: 811 EGIAETSAVITVEEPTEEN----------AEP--PLFINRFQEITVKEKGTIKLVARVTR 858
G SA +TV E ++P P+F+ ++ V + + + +V+
Sbjct: 589 LGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSG 648
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
NP P + W N I SE G L I V E D+G Y C A NSAG+
Sbjct: 649 NPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPE-DTGTYTCEAWNSAGEVRTQ 707
Query: 919 ARVTI----DVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEI-SGMD 971
A +T+ D + F+ +S G++V++ C + + W + K +
Sbjct: 708 AVLTVQEPHDGTQPWFISK-PRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG 766
Query: 972 HREIIQ 977
H E++Q
Sbjct: 767 HFEVLQ 772
Score = 105 bits (251), Expect = 2e-21
Identities = 73/246 (29%), Positives = 105/246 (42%), Gaps = 12/246 (4%)
Query: 487 KLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
K + +D V P +E AP F+ R +G+T +FE +V GYP PQ+TW R
Sbjct: 14 KTSLSVDPSRVDSMPLTE----APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRN 69
Query: 547 TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I F + +LVI V ED G +TC A N +G T EL VE +
Sbjct: 70 GQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAK 129
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGI----PPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ V + I PP F+ K V EG C++ P+
Sbjct: 130 QLGQPVVSKTLGDRFSASAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQ 189
Query: 663 PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLP 722
P + WL + P +SV+ ++ M VL+I V + G YT + VN G+AS+
Sbjct: 190 PQVTWLKGNVPLQPSARVSVSEKNGM----QVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 723 IVLKIK 728
L I+
Sbjct: 246 AELSIQ 251
Score = 95.1 bits (226), Expect = 2e-18
Identities = 50/184 (27%), Positives = 83/184 (45%), Gaps = 1/184 (0%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP+I+ + + +++ G V L W+ K I+ +H K + LT
Sbjct: 1237 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQDSEHIKVENSENGSKLT 1296
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDEPE 1405
I G Y L +EN G ++N+T++DKP PP G P +I SSS+ + W
Sbjct: 1297 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1356
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G S + Y +E + W + T ++Q+L + Y+FR A+N S+ S
Sbjct: 1357 YDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPS 1416
Query: 1466 ETTE 1469
+ +E
Sbjct: 1417 QESE 1420
Score = 94.7 bits (225), Expect = 3e-18
Identities = 69/241 (28%), Positives = 109/241 (45%), Gaps = 30/241 (12%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P + + APIF++ L DGS V QV G P P++ W I+ S+DF +
Sbjct: 614 PVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH-FE 672
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
+L I+EVFPED GT+TC A N+AG + L V+ P H
Sbjct: 673 QRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP---H------------- 716
Query: 621 XXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI 680
+G P F KP++ G +L+ C + P P + WL G+ + D
Sbjct: 717 ---------DGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGH 767
Query: 681 SVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK-TGEKEPPQVIE 739
++++ ++ VLK V+ + G Y ++ NR GE S + L ++ + + P+ E
Sbjct: 768 FEVLQNE-DVFTLVLK--KVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGRE 824
Query: 740 P 740
P
Sbjct: 825 P 825
Score = 89.4 bits (212), Expect = 1e-16
Identities = 42/117 (35%), Positives = 69/117 (58%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 1732 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 1791
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T E IVE
Sbjct: 1792 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAEHIVE 1848
Score = 81.8 bits (193), Expect = 2e-14
Identities = 51/176 (28%), Positives = 80/176 (45%), Gaps = 3/176 (1%)
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
QK + G+ + + G P W K ++++ + + E S + I ++ H
Sbjct: 1247 QKVRAGESVELFGKVTGTQPITCTWMKFRKQIQDSEHIKVENSENGSKLTILAARQEHCG 1306
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
YT+ N G+ +V L V DKP P G +I S+T+ W DGG + Y
Sbjct: 1307 CYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 1366
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESE 1756
+IE + N W ++A ++ +Q L + EY FRV A N G SE + ESE
Sbjct: 1367 SIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 1420
Score = 74.9 bits (176), Expect = 3e-12
Identities = 51/202 (25%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXX 1539
+P+ LK+ +D L C G P P++TW +G+ ++ A++T E
Sbjct: 513 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQD 572
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQ----------------KPVITISNEDIKQ- 1582
Y C+A N G+V S V + + KP I + +
Sbjct: 573 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 632
Query: 1583 KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSK 1642
K G + +T + G PPPEVIW NGN+++ ++++ + + I+E+ +
Sbjct: 633 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPEDTGT 692
Query: 1643 YTIEASNTAGTSSVEVTLKVYD 1664
YT EA N+AG + L V +
Sbjct: 693 YTCEAWNSAGEVRTQAVLTVQE 714
Score = 68.9 bits (161), Expect = 2e-10
Identities = 85/402 (21%), Positives = 161/402 (40%), Gaps = 45/402 (11%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P+F K Q EVKE E++ +V W +G ++ ++ + + L
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 1076 IRNTSVHDEGEYSCILRDE----SCT-----AEVTVVELPPEIITRLQNQKVNKGNKATF 1126
+ D G YSC + SC+ + V+E+ P + L++ V +G
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1127 EIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EV 1180
+ + +G + R W +G IQ++ T + +L I D +D G Y+C +
Sbjct: 534 QCSV-RGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCLAENAL 589
Query: 1181 GNSKCTAILTVEE-----------------PSINFTLRLPEFILVPANTDAYLTVEIP-D 1222
G C+A +TV E P+ L+ + V + +TV++ +
Sbjct: 590 GQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGN 649
Query: 1223 ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLK-V 1281
+V W + I+++E F + +L I++ +D YTC ++ + + V
Sbjct: 650 PPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAV 709
Query: 1282 EVVEFP-----PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII-KKCKHTK 1335
V+ P P + R G V + P P W+ + K + K H +
Sbjct: 710 LTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFE 769
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ +L +KKV+ AG Y++ L+N G ++++ +
Sbjct: 770 VLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLML 811
Score = 66.5 bits (155), Expect = 1e-09
Identities = 91/429 (21%), Positives = 168/429 (39%), Gaps = 47/429 (10%)
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
S+ + +A + + ++ P F ++ Q VKE T+K V+ P P + W+
Sbjct: 391 SQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE 450
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ E + ++ + DSG Y C ASN+ G+ S T+ VE++
Sbjct: 451 GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQVS--CSWTLQVERLA 508
Query: 930 FVK------HLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEI--------SGMDHR 973
++ + K EG+ +L+C T + W N + I +G+
Sbjct: 509 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAEL 568
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETST----MLVV---KETIPEFIRK 1022
I +G + C V ++++S +L V K T P F++
Sbjct: 569 HIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQG 628
Query: 1023 LQDFEVKEKDVAILEVEINSETA-DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSV 1081
L D +V + + V+++ +V+W +G I+ ++ + FE+RG L+I+
Sbjct: 629 LSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED-FHFEQRGTQHSLWIQEVFP 687
Query: 1082 HDEGEYSCIL---RDESCTAEVTVVELP-----PEIITRLQNQKVNKGNKATFEIELTKG 1133
D G Y+C E T V V+ P P I++ ++ + G + G
Sbjct: 688 EDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIA-G 746
Query: 1134 DAL--VRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCT 1186
D V W +DG + + + H ++ + L + AG+Y VG C
Sbjct: 747 DPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQ 806
Query: 1187 AILTVEEPS 1195
L ++ S
Sbjct: 807 VSLMLQNSS 815
Score = 65.7 bits (153), Expect = 2e-09
Identities = 47/213 (22%), Positives = 91/213 (42%), Gaps = 8/213 (3%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S +EY + +K +P + L ++ + +T G P P+V W +G +++
Sbjct: 605 SSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQ 664
Query: 1524 TAK-ATYENRXXXXX---XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT---IS 1576
++ +E R Y C A+N GEV T V+ +Q+ T
Sbjct: 665 ESEDFHFEQRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFI 724
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKEL 1635
++ +G L++ I G P P V W ++G L D + + E + +K++
Sbjct: 725 SKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKV 784
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ H+ +Y I N G S +V+L + + ++
Sbjct: 785 QPWHAGQYEILLKNRVGECSCQVSLMLQNSSAR 817
Score = 62.9 bits (146), Expect = 1e-08
Identities = 60/250 (24%), Positives = 102/250 (40%), Gaps = 23/250 (9%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE Q AP F +KL+ H +G + +CQV P I W +K ++ F + +
Sbjct: 1091 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQE 1149
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDH--GSEM-------- 611
++ ++ I + ED G + CVAKN AG A + ++ V +AP S++ EM
Sbjct: 1150 GSLCSVSIEKALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSS 1209
Query: 612 ------TVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDI 665
T +PP + P+ Q V G + L ++
Sbjct: 1210 LPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITC 1269
Query: 666 AWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVL 725
W+ ++I E+I V + S L I ++ G YT++ N+ G + L
Sbjct: 1270 TWMKFRKQIQDSEHIKVENSEN----GSKLTILAARQEHCGCYTLLVENKLGSRQAQVNL 1325
Query: 726 KIKTGEKEPP 735
+ + +PP
Sbjct: 1326 TV-VDKPDPP 1334
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 33/222 (14%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHS 788
E P I P +++ +++G + +V G P P +TW +N +P+ + L T S
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 789 ITILKPKKVKDEGVYTLKAENS------------EG----------IAET-----SAVIT 821
+ I + +D G YT +A N EG +++T SA
Sbjct: 91 LVIHAVHE-EDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAV 149
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
P+ PP F + + VKE + ++T P P +TW + N + PS ++
Sbjct: 150 ETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSV 209
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ L I V+ + D G Y C+ N +GK+S A ++I
Sbjct: 210 SEKNGMQVLEIHGVNQD-DVGVYTCLVVNGSGKASMSAELSI 250
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/203 (19%), Positives = 85/203 (41%), Gaps = 12/203 (5%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT---YENRXXXX-- 1536
P E ++ + N+ ++ C G+P+P+V W+ +G ++ + + YE+
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI--SNEDIKQKHKV--GDEWLV 1592
Y C A N G+V S + +++ V+ + S + + V G ++++
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ G P P + W NG ++ + T + + + I++ YT A N G
Sbjct: 534 QCSVRGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCLAENALG 590
Query: 1653 TSSVEVTLKVYDKPSKPEGPVIM 1675
S + V++K S + ++
Sbjct: 591 QVSCSAWVTVHEKKSSRKSEYLL 613
Score = 56.8 bits (131), Expect = 8e-07
Identities = 38/132 (28%), Positives = 65/132 (49%), Gaps = 5/132 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + L+ + V +G+ ++L QV +P TI W N K +K + +G S++I
Sbjct: 1098 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1157
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTI 850
K ++D G+Y A+N G AE S +TV++ P EN + P +R + ++
Sbjct: 1158 EK-ALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGT 1216
Query: 851 KLVARVTRNPVP 862
+ A V + P P
Sbjct: 1217 ESDATVKKKPAP 1228
Score = 56.8 bits (131), Expect = 8e-07
Identities = 40/158 (25%), Positives = 69/158 (43%), Gaps = 10/158 (6%)
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
IKV + + + + E+C + ++ +N +G +A V T +D P
Sbjct: 1284 IKVENSENGSKLTILAARQEHCG-CYTLLVENKLGSRQAQ-----VNLTVVDKPDPPAGT 1337
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSIN 1832
I + S+ ++W+ S +GGS + Y +EI K WK +Q L +
Sbjct: 1338 PCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD 1397
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR 1870
Y+FR+ A N GTS P + T+G+ P +P+
Sbjct: 1398 HEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPK 1432
Score = 55.2 bits (127), Expect = 2e-06
Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 2/92 (2%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 1331 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 1388
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
FN++DL +H Y R+ A N G SEP + E
Sbjct: 1389 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 1420
Score = 54.8 bits (126), Expect = 3e-06
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 43/246 (17%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI--------- 680
+G P F +K + +V EG +LL+C++ + P I W G+ + + I
Sbjct: 1094 QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLC 1153
Query: 681 SVAIES----DMHMY------------CSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
SV+IE D +Y CS + E T +R ++SLP V
Sbjct: 1154 SVSIEKALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPV 1213
Query: 725 L--------KIKTGEKEPP------QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK 770
L K K K PP Q+I+ + VR GESV L +V G T TW K
Sbjct: 1214 LGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMK 1273
Query: 771 NNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
K + + + ++ + +TIL ++ + G YTL EN G + +TV + +
Sbjct: 1274 FRKQIQDSEHIKVENSENGSKLTILAARQ-EHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1332
Query: 828 ENAEPP 833
A P
Sbjct: 1333 PPAGTP 1338
Score = 54.4 bits (125), Expect = 4e-06
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
PP+ L ++V++G+ S ++ G P+P +TW K N P++ S + + + +L+
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 219
Query: 794 PKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
V D GVYT N G A SA ++++
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQ 251
Score = 54.0 bits (124), Expect = 6e-06
Identities = 39/152 (25%), Positives = 69/152 (45%), Gaps = 7/152 (4%)
Query: 452 NQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNE-KIDKLPVFEKPTSEEQSMAP 510
++D+ + Q+ T+ W+ + D YT E + + ++P Q P
Sbjct: 666 SEDFHFEQRG-TQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ---P 721
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLV 569
F+ K R G +V C + G P P + W R A+ K + F++ ++D V TLV
Sbjct: 722 WFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNED-VFTLV 780
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+++V P AG + + KN G S L+++
Sbjct: 781 LKKVQPWHAGQYEILLKNRVGECSCQVSLMLQ 812
Score = 54.0 bits (124), Expect = 6e-06
Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 6/129 (4%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P F +KLQD V E +L+ +++S+ A ++W +G+ +K K + G +
Sbjct: 1096 TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQEGSLCS 1154
Query: 1074 LYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
+ I + D G Y C+ ++++ C+ +VTV + P T+ K + + +
Sbjct: 1155 VSIEKALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVL 1214
Query: 1130 LTKGDALVR 1138
T+ DA V+
Sbjct: 1215 GTESDATVK 1223
Score = 53.6 bits (123), Expect = 7e-06
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E+ +E P F + Q++ V E + L +V+ +P +I W N + + ++ I +
Sbjct: 1088 EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILS 1147
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
+G + I E D G YKCVA N AG++ +VT+D
Sbjct: 1148 QEGSLCSVSIEKALLE-DRGLYKCVAKNDAGQAECSCQVTVD 1188
Score = 50.4 bits (115), Expect = 7e-05
Identities = 68/322 (21%), Positives = 122/322 (37%), Gaps = 29/322 (9%)
Query: 1226 DVTWYKKKSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK----LK 1280
+V W+ + + + E + D L + K D Y+C +A+ L+
Sbjct: 444 EVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQ 503
Query: 1281 VE---VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
VE V+E P ++ + G D L + P P W++N + I ++ + +
Sbjct: 504 VERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI---QYARST 560
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS- 1396
++ A L I+ D G Y EN G VT+ +K S +L + S
Sbjct: 561 CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP 620
Query: 1397 ---INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRA 1453
I + + + + V+ E I + N + Q S ++ +
Sbjct: 621 TAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQES-EDFHFEQRGTQHS 679
Query: 1454 YAVNEVDISD-ASETTEYYKVIKETKIQSP-TVEKP-----------LKNITTEPNEDIE 1500
+ EV D + T E + E + Q+ TV++P +++T + +
Sbjct: 680 LWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL 739
Query: 1501 LTCIFGGVPQPKVTWYRDGKKL 1522
++C G P P V W RDGK L
Sbjct: 740 ISCAIAGDPFPTVHWLRDGKAL 761
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+NLK+ S + N+V+ T + E++ +P ++ L+++ + +
Sbjct: 1057 ENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLL 1116
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRX----XXXXXXXXXXXXXXYKCIAFNDH 1556
L C P + W +GK LKT K ++ YKC+A ND
Sbjct: 1117 LQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALLEDRGLYKCVAKNDA 1176
Query: 1557 GEVETSCVVGIQQKP 1571
G+ E SC V + P
Sbjct: 1177 GQAECSCQVTVDDAP 1191
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 42/94 (44%)
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
E P FI + + +KE T K RV P P +TW+RN + I+ +
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
++ + E D G Y C A+N +G +T++
Sbjct: 91 LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVE 124
Score = 47.2 bits (107), Expect = 6e-04
Identities = 34/105 (32%), Positives = 55/105 (52%), Gaps = 6/105 (5%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 1755 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 1812
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLP---IVLKIKTGEKE 733
CS++ I++V + YT AVN GEA+ IV ++ GE E
Sbjct: 1813 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAEHIVETMEEGEGE 1856
Score = 45.6 bits (103), Expect = 0.002
Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
E PP+ T+L V +G F ++T + V W K +Q S + ++ Q
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQV 217
Query: 1163 LKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
L+I+ + DD G Y+C V N A ++ E
Sbjct: 218 LEIHGVNQDDVGVYTCLVVNGSGKASMSAE 247
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/113 (23%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 1729 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 1788
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSS 916
W+++++ I S ++D + N L+I++V + D Y C A NS G+++
Sbjct: 1789 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEAT 1840
Score = 43.6 bits (98), Expect = 0.008
Identities = 23/88 (26%), Positives = 40/88 (45%)
Query: 1295 REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
++ + G + L + P W +N K +K K S + S++I+K D
Sbjct: 1105 QDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALLED 1164
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPS 1382
G+YK +N+ G A+ VT+ D P+
Sbjct: 1165 RGLYKCVAKNDAGQAECSCQVTVDDAPA 1192
Score = 43.2 bits (97), Expect = 0.010
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKD 1934
S+ S S+TL W +GGS + +Y IE K+W ++ T + ++++
Sbjct: 1341 SDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFN--VQDLLPDH 1398
Query: 1935 EIIFRISAENTVGVSLPTESQSV 1957
E FR+ A N G S P++ +
Sbjct: 1399 EYKFRVRAINVYGTSEPSQESEL 1421
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 4/100 (4%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P+V W++NG + + + + + T + I + KYT EA+N +G
Sbjct: 56 VRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGAR 115
Query: 1655 SVEVTLKVYDKPSKPEG-PVIMREI-SRESVT-IEWKPPL 1691
V V L V +K G PV+ + + R S + +E +P +
Sbjct: 116 QVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAVETRPSI 155
Score = 40.7 bits (91), Expect = 0.056
Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 1757 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1816
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
I D DD +Y+C+ NS A T E
Sbjct: 1817 ISDVCGDDDAKYTCKAVNSLGEATCTAE 1844
Score = 39.9 bits (89), Expect = 0.098
Identities = 18/61 (29%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 1780 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 1839
Query: 1655 S 1655
+
Sbjct: 1840 T 1840
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/103 (23%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +LQ+ V +G K + +++ A + W +G ++ + I L+ +G + I
Sbjct: 1098 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1157
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
L+D G Y C + G ++C+ +TV++ + + PE
Sbjct: 1158 EKALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 1200
Score = 37.1 bits (82), Expect = 0.69
Identities = 25/100 (25%), Positives = 43/100 (43%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 1757 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1816
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A VE E E
Sbjct: 1817 ISDVCGDDDAKYTCKAVNSLGEATCTAEHIVETMEEGEGE 1856
Score = 34.7 bits (76), Expect = 3.7
Identities = 19/78 (24%), Positives = 32/78 (41%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G + I G P P+V W K L+ +++ K V+ I + + YT
Sbjct: 173 KEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYT 232
Query: 1645 IEASNTAGTSSVEVTLKV 1662
N +G +S+ L +
Sbjct: 233 CLVVNGSGKASMSAELSI 250
Score = 34.7 bits (76), Expect = 3.7
Identities = 34/128 (26%), Positives = 54/128 (42%), Gaps = 12/128 (9%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALV-RWFKDGSEIQFSNHIQLTIDGKKQKL 1163
+PP+II ++QKV G ++T + W K +IQ S HI++ KL
Sbjct: 1236 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQDSEHIKVENSENGSKL 1295
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAYLTVEIPD 1222
I + G Y+ V N L + +N T + P+ PA T +I
Sbjct: 1296 TILAARQEHCGCYTLLVENK-----LGSRQAQVNLTVVDKPD---PPAGTPC--ASDIRS 1345
Query: 1223 ETLDVTWY 1230
+L ++WY
Sbjct: 1346 SSLTLSWY 1353
Score = 33.9 bits (74), Expect = 6.4
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + PP +IW NG L+ K ++ + + I++ Y
Sbjct: 1112 GKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALLEDRGLYKCV 1171
Query: 1647 ASNTAGTSSVEVTLKVYDKPS 1667
A N AG + + V D P+
Sbjct: 1172 AKNDAGQAECSCQVTVDDAPA 1192
>AY424270-1|AAR29062.1| 1914|Homo sapiens myosin lignt chain
polypeptide kinase isoform 1 protein.
Length = 1914
Score = 134 bits (323), Expect = 4e-30
Identities = 104/431 (24%), Positives = 182/431 (42%), Gaps = 52/431 (12%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
+ S P F K + + + TV+F C+V G P+P++ WF + ++ + Y++
Sbjct: 408 QRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYENA 467
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
L + + D+GT++C A NA G S + L VE
Sbjct: 468 GSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQVER--------------------- 506
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
++E + P+FS K V EG D +L+C + P P I WL G+ I + A
Sbjct: 507 --LAVME-VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEA 563
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASL---------------PIVLKIK 728
+++H I + GTYT +A N G+ S +L +
Sbjct: 564 GVAELH-------IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVA 616
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGD 785
+ P ++ L + V G V ++ QV GNP P + W N ++ + G
Sbjct: 617 PSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGT 676
Query: 786 THSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVK 845
HS+ I + +D G YT +A NS G T AV+TV+EP + P FI++ + +T
Sbjct: 677 QHSLCI-QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP--HDGTQPWFISKPRSVTAS 733
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
++ + + +P P++ W R+ + + + E++ ++ +G Y+
Sbjct: 734 LGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYE 793
Query: 906 CVASNSAGKSS 916
+ N G+ S
Sbjct: 794 ILLKNRVGECS 804
Score = 127 bits (307), Expect = 4e-28
Identities = 96/366 (26%), Positives = 158/366 (43%), Gaps = 29/366 (7%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE-NISVAIESDMHMYC 692
P F KP++Q V E + C + IP+P++AW +G + E +I V + H C
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYENAGSHYLC 473
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQGE 750
+ + GTY+ A N +G+ S L+++ + P LK V +G+
Sbjct: 474 ----LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQ 529
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENS 810
+L V G P P ITW N +P++ + + + I + +D G YT AEN+
Sbjct: 530 DFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHI-QDALPEDHGTYTCLAENA 588
Query: 811 EGIAETSAVITVEEPTEEN----------AEP--PLFINRFQEITVKEKGTIKLVARVTR 858
G SA +TV E ++P P+F+ ++ V + + + +V+
Sbjct: 589 LGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSG 648
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
NP P + W N I SE G L I V E D+G Y C A NSAG+
Sbjct: 649 NPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPE-DTGTYTCEAWNSAGEVRTQ 707
Query: 919 ARVTI----DVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEI-SGMD 971
A +T+ D + F+ +S G++V++ C + + W + K +
Sbjct: 708 AVLTVQEPHDGTQPWFISK-PRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTG 766
Query: 972 HREIIQ 977
H E++Q
Sbjct: 767 HFEVLQ 772
Score = 105 bits (251), Expect = 2e-21
Identities = 73/246 (29%), Positives = 105/246 (42%), Gaps = 12/246 (4%)
Query: 487 KLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
K + +D V P +E AP F+ R +G+T +FE +V GYP PQ+TW R
Sbjct: 14 KTSLSVDPSRVDSMPLTE----APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRN 69
Query: 547 TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I F + +LVI V ED G +TC A N +G T EL VE +
Sbjct: 70 GQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAK 129
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGI----PPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ V + I PP F+ K V EG C++ P+
Sbjct: 130 QLGQPVVSKTLGDRFSASAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQ 189
Query: 663 PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLP 722
P + WL + P +SV+ ++ M VL+I V + G YT + VN G+AS+
Sbjct: 190 PQVTWLKGNVPLQPSARVSVSEKNGM----QVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 723 IVLKIK 728
L I+
Sbjct: 246 AELSIQ 251
Score = 96.3 bits (229), Expect = 1e-18
Identities = 53/200 (26%), Positives = 90/200 (45%), Gaps = 1/200 (0%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP+I+ + + +++ G V L W+ K I++ +H K + LT
Sbjct: 1237 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLT 1296
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDEPE 1405
I G Y L +EN G ++N+T++DKP PP G P +I SSS+ + W
Sbjct: 1297 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1356
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G S + Y +E + W + T ++Q+L + Y+FR A+N S+ S
Sbjct: 1357 YDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPS 1416
Query: 1466 ETTEYYKVIKETKIQSPTVE 1485
+ +E V ++ + VE
Sbjct: 1417 QESELTTVGEKPEEPKDEVE 1436
Score = 95.5 bits (227), Expect = 2e-18
Identities = 69/241 (28%), Positives = 109/241 (45%), Gaps = 30/241 (12%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P + + APIF++ L DGS V QV G P P++ W I+ S+DF +
Sbjct: 614 PVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH-FE 672
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
+L I+EVFPED GT+TC A N+AG + L V+ P H
Sbjct: 673 QRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP---H------------- 716
Query: 621 XXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI 680
+G P F KP++ G +L+ C + P P + WL G+ + D
Sbjct: 717 ---------DGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGH 767
Query: 681 SVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK-TGEKEPPQVIE 739
++++ ++ VLK V+ + G Y ++ NR GE S + L ++ + + P+ E
Sbjct: 768 FEVLQNE-DVFTLVLK--KVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGRE 824
Query: 740 P 740
P
Sbjct: 825 P 825
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 1784 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 1843
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 1844 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1900
Score = 81.4 bits (192), Expect = 3e-14
Identities = 51/176 (28%), Positives = 79/176 (44%), Gaps = 3/176 (1%)
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
QK + G+ + + G P W K +++ + + E S + I ++ H
Sbjct: 1247 QKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCG 1306
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
YT+ N G+ +V L V DKP P G +I S+T+ W DGG + Y
Sbjct: 1307 CYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 1366
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESE 1756
+IE + N W ++A ++ +Q L + EY FRV A N G SE + ESE
Sbjct: 1367 SIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 1420
Score = 74.9 bits (176), Expect = 3e-12
Identities = 51/202 (25%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXX 1539
+P+ LK+ +D L C G P P++TW +G+ ++ A++T E
Sbjct: 513 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQD 572
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQ----------------KPVITISNEDIKQ- 1582
Y C+A N G+V S V + + KP I + +
Sbjct: 573 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 632
Query: 1583 KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSK 1642
K G + +T + G PPPEVIW NGN+++ ++++ + + I+E+ +
Sbjct: 633 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGT 692
Query: 1643 YTIEASNTAGTSSVEVTLKVYD 1664
YT EA N+AG + L V +
Sbjct: 693 YTCEAWNSAGEVRTQAVLTVQE 714
Score = 70.5 bits (165), Expect = 6e-11
Identities = 85/402 (21%), Positives = 161/402 (40%), Gaps = 45/402 (11%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P+F K Q EVKE E++ +V W +G ++ ++ + + L
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYENAGSHYLC 473
Query: 1076 IRNTSVHDEGEYSCILRDE----SCT-----AEVTVVELPPEIITRLQNQKVNKGNKATF 1126
+ D G YSC + SC+ + V+E+ P + L++ V +G
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1127 EIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EV 1180
+ + +G + R W +G IQ++ T + +L I D +D G Y+C +
Sbjct: 534 QCSV-RGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCLAENAL 589
Query: 1181 GNSKCTAILTVEE-----------------PSINFTLRLPEFILVPANTDAYLTVEIP-D 1222
G C+A +TV E P+ L+ + V + +TV++ +
Sbjct: 590 GQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGN 649
Query: 1223 ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLK-V 1281
+V W + I+++E F + +L I++ +D YTC ++ + + V
Sbjct: 650 PPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAV 709
Query: 1282 EVVEFP-----PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKII-KKCKHTK 1335
V+ P P + R G V + P P W+ + K + K H +
Sbjct: 710 LTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFE 769
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ +L +KKV+ AG Y++ L+N G ++++ +
Sbjct: 770 VLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLML 811
Score = 66.5 bits (155), Expect = 1e-09
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE Q AP F +KL+ H +G + +CQV P I W +K ++ F + +
Sbjct: 1091 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQE 1149
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDH 607
++ ++ I + PED G + CVAKN AG A + ++ V +AP S++
Sbjct: 1150 GSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASEN 1195
Score = 65.7 bits (153), Expect = 2e-09
Identities = 47/213 (22%), Positives = 91/213 (42%), Gaps = 8/213 (3%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S +EY + +K +P + L ++ + +T G P P+V W +G +++
Sbjct: 605 SSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQ 664
Query: 1524 TAK-ATYENRXXXXX---XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT---IS 1576
++ +E R Y C A+N GEV T V+ +Q+ T
Sbjct: 665 ESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFI 724
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKEL 1635
++ +G L++ I G P P V W ++G L D + + E + +K++
Sbjct: 725 SKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKV 784
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ H+ +Y I N G S +V+L + + ++
Sbjct: 785 QPWHAGQYEILLKNRVGECSCQVSLMLQNSSAR 817
Score = 65.3 bits (152), Expect = 2e-09
Identities = 91/429 (21%), Positives = 168/429 (39%), Gaps = 47/429 (10%)
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
S+ + +A + + ++ P F ++ Q VKE T+K V+ P P + W+
Sbjct: 391 SQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE 450
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ E + ++ + DSG Y C ASN+ G+ S T+ VE++
Sbjct: 451 GTPVRRQEGSIEVYENAGSHYLCLLKARTRDSGTYSCTASNAQGQVS--CSWTLQVERLA 508
Query: 930 FVK------HLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEI--------SGMDHR 973
++ + K EG+ +L+C T + W N + I +G+
Sbjct: 509 VMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAEL 568
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETST----MLVV---KETIPEFIRK 1022
I +G + C V ++++S +L V K T P F++
Sbjct: 569 HIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQG 628
Query: 1023 LQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSV 1081
L D +V + + V+++ + +V+W +G I+ ++ + FE+RG L I+
Sbjct: 629 LSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED-FHFEQRGTQHSLCIQEVFP 687
Query: 1082 HDEGEYSCIL---RDESCTAEVTVVELP-----PEIITRLQNQKVNKGNKATFEIELTKG 1133
D G Y+C E T V V+ P P I++ ++ + G + G
Sbjct: 688 EDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIA-G 746
Query: 1134 DAL--VRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCT 1186
D V W +DG + + + H ++ + L + AG+Y VG C
Sbjct: 747 DPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQ 806
Query: 1187 AILTVEEPS 1195
L ++ S
Sbjct: 807 VSLMLQNSS 815
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 33/222 (14%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHS 788
E P I P +++ +++G + +V G P P +TW +N +P+ + L T S
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 789 ITILKPKKVKDEGVYTLKAENS------------EG----------IAET-----SAVIT 821
+ I + +D G YT +A N EG +++T SA
Sbjct: 91 LVIHAVHE-EDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAV 149
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
P+ PP F + + VKE + ++T P P +TW + N + PS ++
Sbjct: 150 ETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSV 209
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ L I V+ + D G Y C+ N +GK+S A ++I
Sbjct: 210 SEKNGMQVLEIHGVNQD-DVGVYTCLVVNGSGKASMSAELSI 250
Score = 61.7 bits (143), Expect = 3e-08
Identities = 41/203 (20%), Positives = 85/203 (41%), Gaps = 12/203 (5%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT---YENRXXXX-- 1536
P E ++ + N+ ++ C G+P+P+V W+ +G ++ + + YEN
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYENAGSHYLC 473
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI--SNEDIKQKHKV--GDEWLV 1592
Y C A N G+V S + +++ V+ + S + + V G ++++
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQVSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ G P P + W NG ++ + T + + + I++ YT A N G
Sbjct: 534 QCSVRGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCLAENALG 590
Query: 1653 TSSVEVTLKVYDKPSKPEGPVIM 1675
S + V++K S + ++
Sbjct: 591 QVSCSAWVTVHEKKSSRKSEYLL 613
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/200 (24%), Positives = 87/200 (43%), Gaps = 12/200 (6%)
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
+KV + + + + E+C + ++ +N +G +A V T +D P
Sbjct: 1284 MKVENSENGSKLTILAARQEHCG-CYTLLVENKLGSRQAQ-----VNLTVVDKPDPPAGT 1337
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSIN 1832
I + S+ ++W+ S +GGS + Y +EI K WK +Q L +
Sbjct: 1338 PCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD 1397
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEPES 1891
Y+FR+ A N GTS P + T+G+ P +P++ V VS+ + + +
Sbjct: 1398 HEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPKDEVEVSDDDEKEPEVDYRTVTI 1454
Query: 1892 NGGSPITN-YIIEFKTVKGK 1910
N +++ Y IE + GK
Sbjct: 1455 NTEQKVSDFYDIEERLGSGK 1474
Score = 58.0 bits (134), Expect = 3e-07
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 1331 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 1388
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
FN++DL +H Y R+ A N G SEP + E V GE EEP ++ EV
Sbjct: 1389 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTV--GE---KPEEPKDEVEV 1437
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 5/132 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + L+ + V +G+ ++L QV +P TI W N K +K + +G S++I
Sbjct: 1098 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1157
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTI 850
K +D G+Y A+N G AE S +TV++ P EN + P +R + ++
Sbjct: 1158 EKALP-EDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGT 1216
Query: 851 KLVARVTRNPVP 862
+ A V + P P
Sbjct: 1217 ESDATVKKKPAP 1228
Score = 55.2 bits (127), Expect = 2e-06
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 43/246 (17%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI--------- 680
+G P F +K + +V EG +LL+C++ + P I W G+ + + I
Sbjct: 1094 QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLC 1153
Query: 681 SVAIES----DMHMY------------CSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
SV+IE D +Y CS + E T +R ++SLP V
Sbjct: 1154 SVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPV 1213
Query: 725 L--------KIKTGEKEPP------QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK 770
L K K K PP Q+I+ + VR GESV L +V G T TW K
Sbjct: 1214 LGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMK 1273
Query: 771 NNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
K ++ + ++ + +TIL ++ + G YTL EN G + +TV + +
Sbjct: 1274 FRKQIQESEHMKVENSENGSKLTILAARQ-EHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1332
Query: 828 ENAEPP 833
A P
Sbjct: 1333 PPAGTP 1338
Score = 54.4 bits (125), Expect = 4e-06
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
PP+ L ++V++G+ S ++ G P+P +TW K N P++ S + + + +L+
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 219
Query: 794 PKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
V D GVYT N G A SA ++++
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQ 251
Score = 54.0 bits (124), Expect = 6e-06
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E+ +E P F + Q++ V E + L +V+ +P +I W N + + ++ I +
Sbjct: 1088 EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILS 1147
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
+G + I E D G YKCVA N AG++ +VT+D
Sbjct: 1148 QEGSLCSVSIEKALPE-DRGLYKCVAKNDAGQAECSCQVTVD 1188
Score = 52.8 bits (121), Expect = 1e-05
Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P F +KLQD V E +L+ +++S+ A ++W +G+ +K K + G +
Sbjct: 1096 TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQEGSLCS 1154
Query: 1074 LYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
+ I D G Y C+ ++++ C+ +VTV + P T+ K + + +
Sbjct: 1155 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVL 1214
Query: 1130 LTKGDALVR 1138
T+ DA V+
Sbjct: 1215 GTESDATVK 1223
Score = 49.6 bits (113), Expect = 1e-04
Identities = 67/322 (20%), Positives = 122/322 (37%), Gaps = 29/322 (9%)
Query: 1226 DVTWYKKKSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK----LK 1280
+V W+ + + + E + + L + K D Y+C +A+ L+
Sbjct: 444 EVAWFLEGTPVRRQEGSIEVYENAGSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQ 503
Query: 1281 VE---VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
VE V+E P ++ + G D L + P P W++N + I ++ + +
Sbjct: 504 VERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI---QYARST 560
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSS- 1396
++ A L I+ D G Y EN G VT+ +K S +L + S
Sbjct: 561 CEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP 620
Query: 1397 ---INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRA 1453
I + + + + V+ E I + N + Q S ++ +
Sbjct: 621 TAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQES-EDFHFEQRGTQHS 679
Query: 1454 YAVNEVDISD-ASETTEYYKVIKETKIQSP-TVEKP-----------LKNITTEPNEDIE 1500
+ EV D + T E + E + Q+ TV++P +++T + +
Sbjct: 680 LCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVL 739
Query: 1501 LTCIFGGVPQPKVTWYRDGKKL 1522
++C G P P V W RDGK L
Sbjct: 740 ISCAIAGDPFPTVHWLRDGKAL 761
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 1807 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 1864
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 1865 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 1904
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+NLK+ S + N+V+ T + E++ +P ++ L+++ + +
Sbjct: 1057 ENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLL 1116
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX----XXXYKCIAFNDH 1556
L C P + W +GK LKT K ++ YKC+A ND
Sbjct: 1117 LQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDA 1176
Query: 1557 GEVETSCVVGIQQKP 1571
G+ E SC V + P
Sbjct: 1177 GQAECSCQVTVDDAP 1191
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 42/94 (44%)
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
E P FI + + +KE T K RV P P +TW+RN + I+ +
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
++ + E D G Y C A+N +G +T++
Sbjct: 91 LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVE 124
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 1781 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 1840
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 1841 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 1899
Query: 924 D 924
+
Sbjct: 1900 E 1900
Score = 45.6 bits (103), Expect = 0.002
Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
E PP+ T+L V +G F ++T + V W K +Q S + ++ Q
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQV 217
Query: 1163 LKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
L+I+ + DD G Y+C V N A ++ E
Sbjct: 218 LEIHGVNQDDVGVYTCLVVNGSGKASMSAE 247
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 4/101 (3%)
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKD 1934
S+ S S+TL W +GGS + +Y IE K+W ++ T + ++++
Sbjct: 1341 SDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFN--VQDLLPDH 1398
Query: 1935 EIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
E FR+ A N G S P SQ L P P +E+
Sbjct: 1399 EYKFRVRAINVYGTSEP--SQESELTTVGEKPEEPKDEVEV 1437
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/88 (26%), Positives = 40/88 (45%)
Query: 1295 REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
++ + G + L + P W +N K +K K S + S++I+K D
Sbjct: 1105 QDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPED 1164
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPS 1382
G+YK +N+ G A+ VT+ D P+
Sbjct: 1165 RGLYKCVAKNDAGQAECSCQVTVDDAPA 1192
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 1809 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1868
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 1869 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1900
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 4/100 (4%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P+V W++NG + + + + + T + I + KYT EA+N +G
Sbjct: 56 VRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGAR 115
Query: 1655 SVEVTLKVYDKPSKPEG-PVIMREI-SRESVT-IEWKPPL 1691
V V L V +K G PV+ + + R S + +E +P +
Sbjct: 116 QVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAVETRPSI 155
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 1832 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 1891
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 1892 TCTAELIV 1899
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 1809 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1868
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 1869 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 1908
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/103 (22%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +LQ+ V +G K + +++ A + W +G ++ + I L+ +G + I
Sbjct: 1098 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1157
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
+D G Y C + G ++C+ +TV++ + + PE
Sbjct: 1158 EKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 1200
Score = 34.7 bits (76), Expect = 3.7
Identities = 19/78 (24%), Positives = 32/78 (41%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G + I G P P+V W K L+ +++ K V+ I + + YT
Sbjct: 173 KEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYT 232
Query: 1645 IEASNTAGTSSVEVTLKV 1662
N +G +S+ L +
Sbjct: 233 CLVVNGSGKASMSAELSI 250
Score = 33.9 bits (74), Expect = 6.4
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + PP +IW NG L+ K ++ + + I++ Y
Sbjct: 1112 GKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCV 1171
Query: 1647 ASNTAGTSSVEVTLKVYDKPS 1667
A N AG + + V D P+
Sbjct: 1172 AKNDAGQAECSCQVTVDDAPA 1192
Score = 33.5 bits (73), Expect = 8.5
Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 12/128 (9%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALV-RWFKDGSEIQFSNHIQLTIDGKKQKL 1163
+PP+II ++QKV G ++T + W K +IQ S H+++ KL
Sbjct: 1236 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKL 1295
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAYLTVEIPD 1222
I + G Y+ V N L + +N T + P+ PA T +I
Sbjct: 1296 TILAARQEHCGCYTLLVENK-----LGSRQAQVNLTVVDKPD---PPAGTPC--ASDIRS 1345
Query: 1223 ETLDVTWY 1230
+L ++WY
Sbjct: 1346 SSLTLSWY 1353
>AF491813-1|AAM09558.1| 2113|Homo sapiens Down syndrome cell adhesion
molecule 2 protein.
Length = 2113
Score = 130 bits (314), Expect = 5e-29
Identities = 317/1535 (20%), Positives = 562/1535 (36%), Gaps = 164/1535 (10%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQIT---WFRQTAIIKPSQDFQMYYDDDNVATL 568
+ ++ + + G+ F+C + + ++ W + T I P F + Y L
Sbjct: 187 YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG----L 242
Query: 569 VIREVFPEDA-GTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
I +V EDA T+ C+ K+ ++ T + +G+ ++V D
Sbjct: 243 YISDVQKEDALSTYRCITKHK--YSGETRQ--------SNGARLSVT------------D 280
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
E IP T +Q V G + L C P P I WL G + D + I
Sbjct: 281 PAESIP-TILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG- 338
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
L I++++ GTY N G A +L + +P V K +
Sbjct: 339 -------LTISDLRTEDSGTYICEVTNTFGSAEATGILMVI----DPLHVTLTPKKLKTG 387
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYT 804
G +VILS + G+P TI W +N + V LP ++ G ++ ++ + G Y
Sbjct: 388 IGSTVILSCALTGSPEFTIRWYRNTELV--LPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
A A+ A+I +E+ T P ++ F E V L+ P P++
Sbjct: 446 CFATRKAQTAQDFAIIALEDGT------PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTV 499
Query: 865 TWYRNNE-IISPSETITQNF---DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
TW ++E I+ T + DG I + D G Y+C A N G + + AR
Sbjct: 500 TWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQAR 559
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQE 978
I+V ++ + ++ G+ ++ C+ S KWY + + +HR+++ E
Sbjct: 560 --INVRGPPSIRAM-RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPD-NHRQVVFE 615
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVA-ILE 1037
D G C V Q ++ + +Q FE + +L
Sbjct: 616 -NGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLY 674
Query: 1038 VEINSETAD----VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ + D + W +DG++I + E + + L I + S+ G Y+CI +
Sbjct: 675 IPCVVSSGDMPIRITWRKDGQVI-ISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 733
Query: 1094 ESCTA---EVTVVELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS 1149
+ T +V +PP + + NQ G + V W
Sbjct: 734 AAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ 793
Query: 1150 NHIQLTIDGKKQ-----KLKIYDCDLDDAGEYSCEVGNSKCTAI-----LTVEEPSINFT 1199
+ + + G+ Q L I +D G Y C+ N T I LTV+ P++ T
Sbjct: 794 QYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAM-IT 852
Query: 1200 LRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE--KFTLIS----DVKKRTL 1253
I + + + + + W K +VI+ ++ + + D TL
Sbjct: 853 SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTL 912
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQ 1312
++ D ++C +++ + +++ V+ PP E E R + + L Q
Sbjct: 913 KLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD--PPELEIREVKARSMNLRWT-Q 969
Query: 1313 AFPQPNDEWIVNSKIIKKCKHTKPSI--DSKSASLTIKKVENTD---AGIYKLRLE--NN 1365
F + I I K K +++ S TI + D A +Y +R+ N
Sbjct: 970 RF--DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
Query: 1366 CGHADVEMNVTI-LDKPSPPGKP---NILEIDSSSINICWDEP-ENTGNSTIIYYVVEYQ 1420
G ++ +TI ++ +P G P + + S SI + W P + N I Y + Y+
Sbjct: 1028 IGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYR 1087
Query: 1421 EID--TTEWISVKNITKTQTS----IQNLKTNSSYRFRAYAVNEVDISDASE-----TTE 1469
E + S+ + T S + NLK + Y A N +S T E
Sbjct: 1088 ENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLE 1147
Query: 1470 YYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY 1529
+++ ++ + I+ L + G + Y DG+ + T
Sbjct: 1148 DVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNIT- 1206
Query: 1530 ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK----QKHK 1585
R + +A+ G+ S V+ IQ K + IK
Sbjct: 1207 TTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASS 1266
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKN-GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
V WL G+ I+ + G+ EY T + RI L R
Sbjct: 1267 VVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYE--TSPEQLFYRIAHLNRGQQYLLW 1324
Query: 1645 IEASNTA--GTSSVEVTLKVYDKPSKPEGPVIMREIS-RESVTIEW----KPPLDDGGLE 1697
+ A +A G SS +VT+ +P G + IS +VT W + P + G
Sbjct: 1325 VAAVTSAGRGNSSEKVTI-------EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDP 1377
Query: 1698 LTKYAIEKHEPDNNRWIKVADVDRDVE---TYCIQKLNENCEYMFRVIAQNPVGFSEALE 1754
K D+ + + D R + T ++ + + A N GF
Sbjct: 1378 APAVKWTKDSEDSAIPVSM-DGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF----- 1431
Query: 1755 SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKW 1813
+ I++ + VP S+ +TW P + NGGS I + ++ ++W
Sbjct: 1432 -DTIIVNLLVQVPPDQPRLTVSKT-SASSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEW 1488
Query: 1814 KXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNF 1872
K + ++ L T Y+ ++ A+N +G+ + T G+ + F
Sbjct: 1489 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLF 1548
Query: 1873 VVSESTSRSVTLK-WTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIK 1931
ST + L+ W +NGG PIT ++E++ KG +W S E + ++
Sbjct: 1549 THINSTHARLNLQGW----NNGGCPITAIVLEYRP-KG-TWAWQGLRANSSGEVFLTELR 1602
Query: 1932 EKDEIIFRISAENTVGVSLPTESQSVRLEKHATVP 1966
E R+ A N+ G T + +T+P
Sbjct: 1603 EATWYELRMRACNSAGCGNETAQFATLDYDGSTIP 1637
Score = 120 bits (289), Expect = 6e-26
Identities = 221/1098 (20%), Positives = 417/1098 (37%), Gaps = 124/1098 (11%)
Query: 1022 KLQDFEVKEKDVAILEVEINSETADVV----WERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
+++D +VA+ + I S + V WE+D I P+ + G LYI
Sbjct: 190 RVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGG----LYIS 245
Query: 1078 NTSVHDE-GEYSCILRD-------ESCTAEVTVV---ELPPEIITRLQNQKVNKGNKATF 1126
+ D Y CI + +S A ++V E P I+ +Q+V G+ T
Sbjct: 246 DVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGH--TV 303
Query: 1127 EIELTKGD---ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV--- 1180
E+ T +RW KDG + + I G L I D +D+G Y CEV
Sbjct: 304 ELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYICEVTNT 359
Query: 1181 -GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET-LDVTWYKKKSVIED 1238
G+++ T IL V +P ++ TL P+ + + L+ + + WY+ ++
Sbjct: 360 FGSAEATGILMVIDP-LHVTLT-PKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLP 417
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFPPKIVDYERE 1296
E + I + TL+I + Y C T + + + + P+IV E
Sbjct: 418 DEAIS-IRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSE 476
Query: 1297 YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT--- 1353
+ G +L+ + P P W ++ + I + + + + S TI + T
Sbjct: 477 KVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQ 536
Query: 1354 --DAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
D G+Y+ N G A+ + + + PS NI + I N
Sbjct: 537 IRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLI------NCRVIG 590
Query: 1412 IIYYVVE-YQEI----DTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
YY ++ Y++ D + +N T T +Q Y ++ IS +
Sbjct: 591 YPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVH 650
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQP-KVTWYRDGKKLKTA 1525
++ P + +P + + + + C+ P ++TW +DG+ + +
Sbjct: 651 VA----------VKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISG 700
Query: 1526 KA-TYENRXXXXXXXXXXXXXXX---YKCIAFNDHGEV--ETSCVVGIQQKPVITISNED 1579
T E++ Y CIA N V E +V + + V+ +N+D
Sbjct: 701 SGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQD 760
Query: 1580 IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN---ITTKEK---TSVIRIK 1633
G ++ ++G PPP+V+W K+ N ++Y+ +T + + S + I+
Sbjct: 761 ----GIYGKAGVLNCSVDGYPPPKVMW-KHAKGSGNPQQYHPVPLTGRIQILPNSSLLIR 815
Query: 1634 ELKRSHSSKYTIEASNTAGTS---SVEVTLKVYDK-PSKPEGPVIMREISRE-SVTIEWK 1688
+ Y +ASN GT S+ +T+K+ S P + ++ ++E + T +
Sbjct: 816 HVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGE 875
Query: 1689 PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD-----VETYCIQKLNENCEYMFRVIA 1743
P+ + ++ D +R ++ A +D V T ++ + F A
Sbjct: 876 RPI------IIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHA 929
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G L + ++ D P + S+ + W +G S I +
Sbjct: 930 INSYGEDRGLIQ--LTVQEPPDPPELEIRE-----VKARSMNLRW-TQRFDGNSIITGFD 981
Query: 1804 VEIKQEGKKWKXXXXXXXXXARIQKLSI-----NTTYQFRIYARNEIGTSLPYTSDDKIT 1858
+E K + W I + +I + Y R+Y+ N+IG S P ++T
Sbjct: 982 IEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEP---SKELT 1038
Query: 1859 IG-KTLTPPSQPRNFVVSESTSRSVTLKWTEPESN-GGSPITNYIIEFKT----VKGKSW 1912
I + P P + + TS+S+ + W P+ I Y I ++ G+
Sbjct: 1039 ISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYS 1098
Query: 1913 TKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAP 1972
+ G + ++N+K+ + + A N G P+ S+ + VPS P
Sbjct: 1099 IVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSE-INATTLEDVPSQPPEN 1156
Query: 1973 LEIRMVGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDV-TKTMWMEVGKVDVNTLKFNIRD 2030
+ + S++ + SW P L GY + + W E+ + + +R
Sbjct: 1157 VRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRG 1216
Query: 2031 LSENHTYMIRIYARNEIG 2048
+ + Y +++ A + G
Sbjct: 1217 MEKFTNYSVQVLAYTQAG 1234
Score = 90.2 bits (214), Expect = 7e-17
Identities = 157/749 (20%), Positives = 266/749 (35%), Gaps = 49/749 (6%)
Query: 651 ILLECRLVAIPEPDIAW-LFKGEEIVPDENIS-VAIESDMHMYCSVLKITNVKKFQEGTY 708
+++ C P + W L G++I +I V + +Y N + Y
Sbjct: 103 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFN-SFIHDNDY 161
Query: 709 TVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
A N G+ P + ++K +EP V +E +SM L V ++
Sbjct: 162 FCTAENAAGKIRSPNI-RVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Query: 768 WCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
W K+ P G + + K + T + E A ++V +
Sbjct: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P E P ++ F V T++L + P+P+I W ++ + T+
Sbjct: 281 PAESI---PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKS-SHGARVTIDVEKVTFVKHLQKSYETEEG 943
G L I+++ +E DSG Y C +N+ G + + G + ID VT K +T G
Sbjct: 338 G----LTISDLRTE-DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTP---KKLKTGIG 389
Query: 944 KTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
TVIL C S + +WY N E+ D I+ G +C
Sbjct: 390 STVILSCALTGSPEFTIRWYRNT-ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 448
Query: 1002 -KDQETS---TMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVVWERDGEII 1056
+ +T+ ++ +++ P + + V + +++ + V W D E I
Sbjct: 449 TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 508
Query: 1057 ----KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEI 1109
+ N+Y I + + + D G Y C R+ +AE V PP I
Sbjct: 509 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 568
Query: 1110 ITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDC 1168
++N G + ++W+KD + NH Q+ + KL
Sbjct: 569 -RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLP-DNHRQVVFENGTLKLTDVQK 626
Query: 1169 DLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL----TVEIPDET 1224
+D+ GEY C V +I ++ + F PA+ L V D
Sbjct: 627 GMDE-GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMP 685
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE-V 1283
+ +TW K VI T+ S +L I + YTC+ +A +T + + +
Sbjct: 686 IRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLI 745
Query: 1284 VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEW-IVNSKIIKKCKHTKPSIDS-- 1340
V PP+ V G L +P P W + H P
Sbjct: 746 VRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQ 805
Query: 1341 --KSASLTIKKVENTDAGIYKLRLENNCG 1367
++SL I+ V D G Y + N G
Sbjct: 806 ILPNSSLLIRHVLEEDIGYYLCQASNGVG 834
Score = 61.7 bits (143), Expect = 3e-08
Identities = 96/440 (21%), Positives = 167/440 (37%), Gaps = 36/440 (8%)
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI- 1678
NITT + +R E ++S + + A AG L + K P P ++ +
Sbjct: 1204 NITTTRERVELRGMEKFTNYSVQ--VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVP 1261
Query: 1679 -SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCE 1736
S SV + W PP G+ + KY I P + + + + Y I LN +
Sbjct: 1262 SSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1320
Query: 1737 YMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGG 1796
Y+ V A G + SE + I+ A P+ +V W +
Sbjct: 1321 YLLWVAAVTSAGRGNS--SEKVTIEPAGKAPAKIISFGG-------TVTTPWMKDVRLPC 1371
Query: 1797 SPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG----TSLPYT 1852
+ + D +K R+ + N T R + G T+
Sbjct: 1372 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRL--IHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
Query: 1853 SDDKITIGKTL-TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS 1911
D I + + PP QPR VS++++ S+TL W P NGGS I +++++ +
Sbjct: 1430 GFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEE 1487
Query: 1912 WTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPS---P 1968
W K V + S ++++K +++A+N+VG S+ + + H PS
Sbjct: 1488 W-KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG--RISEIIEAKTHGREPSFSKD 1544
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNI 2028
I + + + W +GG P+ + R K W G ++ + +
Sbjct: 1545 QHLFTHINSTHARLNLQGWN----NGGCPITAIVLEYR--PKGTWAWQGLRANSSGEVFL 1598
Query: 2029 RDLSENHTYMIRIYARNEIG 2048
+L E Y +R+ A N G
Sbjct: 1599 TELREATWYELRMRACNSAG 1618
Score = 47.2 bits (107), Expect = 6e-04
Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 5/108 (4%)
Query: 499 EKPTSEEQSMAPIFVEKLRPK-HTPDGSTVQFECQVEGYPRPQITWFRQT--AIIKPSQD 555
EK T E AP + TP V+ C G P P + W + + + I S D
Sbjct: 1338 EKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD 1397
Query: 556 FQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ TL++R V ED+G +TC A N GF + L+V+ P
Sbjct: 1398 GHRLIHTNG--TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1443
Score = 45.6 bits (103), Expect = 0.002
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 4/92 (4%)
Query: 1964 TVPSPPTAP-LEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
TV PP P LEIR V + + W T +DG + + G++I ++ + + + +++
Sbjct: 943 TVQEPPDPPELEIREVKARSMNLRW-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNIS 1001
Query: 2023 TL--KFNIRDLSENHTYMIRIYARNEIGLSEP 2052
+ NI DL Y IR+Y+ N+IG SEP
Sbjct: 1002 PTINQANIVDLHPASVYSIRMYSFNKIGRSEP 1033
Score = 44.8 bits (101), Expect = 0.003
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 5/95 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P ++ + G TV+ C GYP P I W + + + + L
Sbjct: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK-----RITGLT 340
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
I ++ ED+GT+ C N G A +T L+V PL
Sbjct: 341 ISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 375
Score = 34.7 bits (76), Expect = 3.7
Identities = 25/100 (25%), Positives = 34/100 (34%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKP-SQDFQMYYDDDNVAT 567
P V K G C +G P P +TW I++ S Y D
Sbjct: 468 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 527
Query: 568 LVIREVFPE--DAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ P+ D G + C A+N G A + V P S
Sbjct: 528 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 567
>AF334384-1|AAL57166.1| 2053|Homo sapiens Down syndrome cell adhesion
molecule DSCAML1 protein.
Length = 2053
Score = 130 bits (314), Expect = 5e-29
Identities = 317/1535 (20%), Positives = 562/1535 (36%), Gaps = 164/1535 (10%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQIT---WFRQTAIIKPSQDFQMYYDDDNVATL 568
+ ++ + + G+ F+C + + ++ W + T I P F + Y L
Sbjct: 127 YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPENRFFITYHGG----L 182
Query: 569 VIREVFPEDA-GTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
I +V EDA T+ C+ K+ ++ T + +G+ ++V D
Sbjct: 183 YISDVQKEDALSTYRCITKHK--YSGETRQ--------SNGARLSVT------------D 220
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
E IP T +Q V G + L C P P I WL G + D + I
Sbjct: 221 PAESIP-TILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG- 278
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
L I++++ GTY N G A +L + +P V K +
Sbjct: 279 -------LTISDLRTEDSGTYICEVTNTFGSAEATGILMV----IDPLHVTLTPKKLKTG 327
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYT 804
G +VILS + G+P TI W +N + V LP ++ G ++ ++ + G Y
Sbjct: 328 IGSTVILSCALTGSPEFTIRWYRNTELV--LPDEAISIRGLSNETLLITSAQKSHSGAYQ 385
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
A A+ A+I +E+ T P ++ F E V L+ P P++
Sbjct: 386 CFATRKAQTAQDFAIIALEDGT------PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTV 439
Query: 865 TWYRNNE-IISPSETITQNF---DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
TW ++E I+ T + DG I + D G Y+C A N G + + AR
Sbjct: 440 TWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQAR 499
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQE 978
I+V ++ + ++ G+ ++ C+ S KWY + + +HR+++ E
Sbjct: 500 --INVRGPPSIRAM-RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPD-NHRQVVFE 555
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVA-ILE 1037
D G C V Q ++ + +Q FE + +L
Sbjct: 556 -NGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLY 614
Query: 1038 VEINSETAD----VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ + D + W +DG++I + E + + L I + S+ G Y+CI +
Sbjct: 615 IPCVVSSGDMPIRITWRKDGQVI-ISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 673
Query: 1094 ESCTA---EVTVVELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS 1149
+ T +V +PP + + NQ G + V W
Sbjct: 674 AAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ 733
Query: 1150 NHIQLTIDGKKQ-----KLKIYDCDLDDAGEYSCEVGNSKCTAI-----LTVEEPSINFT 1199
+ + + G+ Q L I +D G Y C+ N T I LTV+ P++ T
Sbjct: 734 QYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAM-IT 792
Query: 1200 LRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE--KFTLIS----DVKKRTL 1253
I + + + + + W K +VI+ ++ + + D TL
Sbjct: 793 SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTL 852
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQ 1312
++ D ++C +++ + +++ V+ PP E E R + + L Q
Sbjct: 853 KLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD--PPELEIREVKARSMNLRWT-Q 909
Query: 1313 AFPQPNDEWIVNSKIIKKCKHTKPSI--DSKSASLTIKKVENTD---AGIYKLRLE--NN 1365
F + I I K K +++ S TI + D A +Y +R+ N
Sbjct: 910 RF--DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 967
Query: 1366 CGHADVEMNVTI-LDKPSPPGKP---NILEIDSSSINICWDEP-ENTGNSTIIYYVVEYQ 1420
G ++ +TI ++ +P G P + + S SI + W P + N I Y + Y+
Sbjct: 968 IGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYR 1027
Query: 1421 EID--TTEWISVKNITKTQTS----IQNLKTNSSYRFRAYAVNEVDISDASE-----TTE 1469
E + S+ + T S + NLK + Y A N +S T E
Sbjct: 1028 ENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLE 1087
Query: 1470 YYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY 1529
+++ ++ + I+ L + G + Y DG+ + T
Sbjct: 1088 DVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNIT- 1146
Query: 1530 ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK----QKHK 1585
R + +A+ G+ S V+ IQ K + IK
Sbjct: 1147 TTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASS 1206
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKN-GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
V WL G+ I+ + G+ EY T + RI L R
Sbjct: 1207 VVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYE--TSPEQLFYRIAHLNRGQQYLLW 1264
Query: 1645 IEASNTA--GTSSVEVTLKVYDKPSKPEGPVIMREIS-RESVTIEW----KPPLDDGGLE 1697
+ A +A G SS +VT+ +P G + IS +VT W + P + G
Sbjct: 1265 VAAVTSAGRGNSSEKVTI-------EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDP 1317
Query: 1698 LTKYAIEKHEPDNNRWIKVADVDRDVE---TYCIQKLNENCEYMFRVIAQNPVGFSEALE 1754
K D+ + + D R + T ++ + + A N GF
Sbjct: 1318 APAVKWTKDSEDSAIPVSM-DGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF----- 1371
Query: 1755 SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKW 1813
+ I++ + VP S+ +TW P + NGGS I + ++ ++W
Sbjct: 1372 -DTIIVNLLVQVPPDQPRLTVSKT-SASSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEW 1428
Query: 1814 KXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNF 1872
K + ++ L T Y+ ++ A+N +G+ + T G+ + F
Sbjct: 1429 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLF 1488
Query: 1873 VVSESTSRSVTLK-WTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIK 1931
ST + L+ W +NGG PIT ++E++ KG +W S E + ++
Sbjct: 1489 THINSTHARLNLQGW----NNGGCPITAIVLEYRP-KG-TWAWQGLRANSSGEVFLTELR 1542
Query: 1932 EKDEIIFRISAENTVGVSLPTESQSVRLEKHATVP 1966
E R+ A N+ G T + +T+P
Sbjct: 1543 EATWYELRMRACNSAGCGNETAQFATLDYDGSTIP 1577
Score = 122 bits (294), Expect = 1e-26
Identities = 222/1098 (20%), Positives = 419/1098 (38%), Gaps = 124/1098 (11%)
Query: 1022 KLQDFEVKEKDVAILEVEINSETADVV----WERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
+++D +VA+ + I S + V WE+D I P+ N++ G LYI
Sbjct: 130 RVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPE-NRFFITYHGG---LYIS 185
Query: 1078 NTSVHDE-GEYSCILRD-------ESCTAEVTVV---ELPPEIITRLQNQKVNKGNKATF 1126
+ D Y CI + +S A ++V E P I+ +Q+V G+ T
Sbjct: 186 DVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGH--TV 243
Query: 1127 EIELTKGD---ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV--- 1180
E+ T +RW KDG + + I G L I D +D+G Y CEV
Sbjct: 244 ELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYICEVTNT 299
Query: 1181 -GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET-LDVTWYKKKSVIED 1238
G+++ T IL V +P ++ TL P+ + + L+ + + WY+ ++
Sbjct: 300 FGSAEATGILMVIDP-LHVTLT-PKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLP 357
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFPPKIVDYERE 1296
E + I + TL+I + Y C T + + + + P+IV E
Sbjct: 358 DEAIS-IRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSE 416
Query: 1297 YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT--- 1353
+ G +L+ + P P W ++ + I + + + + S TI + T
Sbjct: 417 KVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQ 476
Query: 1354 --DAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
D G+Y+ N G A+ + + + PS NI + I N
Sbjct: 477 IRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLI------NCRVIG 530
Query: 1412 IIYYVVE-YQEI----DTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
YY ++ Y++ D + +N T T +Q Y ++ IS +
Sbjct: 531 YPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVH 590
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQP-KVTWYRDGKKLKTA 1525
++ P + +P + + + + C+ P ++TW +DG+ + +
Sbjct: 591 VA----------VKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISG 640
Query: 1526 KA-TYENRXXXXXXXXXXXXXXX---YKCIAFNDHGEV--ETSCVVGIQQKPVITISNED 1579
T E++ Y CIA N V E +V + + V+ +N+D
Sbjct: 641 SGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQD 700
Query: 1580 IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN---ITTKEK---TSVIRIK 1633
G ++ ++G PPP+V+W K+ N ++Y+ +T + + S + I+
Sbjct: 701 ----GIYGKAGVLNCSVDGYPPPKVMW-KHAKGSGNPQQYHPVPLTGRIQILPNSSLLIR 755
Query: 1634 ELKRSHSSKYTIEASNTAGTS---SVEVTLKVYDK-PSKPEGPVIMREISRE-SVTIEWK 1688
+ Y +ASN GT S+ +T+K+ S P + ++ ++E + T +
Sbjct: 756 HVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGE 815
Query: 1689 PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD-----VETYCIQKLNENCEYMFRVIA 1743
P+ + ++ D +R ++ A +D V T ++ + F A
Sbjct: 816 RPI------IIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHA 869
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G L + ++ D P + S+ + W +G S I +
Sbjct: 870 INSYGEDRGLIQ--LTVQEPPDPPELEIRE-----VKARSMNLRW-TQRFDGNSIITGFD 921
Query: 1804 VEIKQEGKKWKXXXXXXXXXARIQKLSI-----NTTYQFRIYARNEIGTSLPYTSDDKIT 1858
+E K + W I + +I + Y R+Y+ N+IG S P ++T
Sbjct: 922 IEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEP---SKELT 978
Query: 1859 IG-KTLTPPSQPRNFVVSESTSRSVTLKWTEPESN-GGSPITNYIIEFKT----VKGKSW 1912
I + P P + + TS+S+ + W P+ I Y I ++ G+
Sbjct: 979 ISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYS 1038
Query: 1913 TKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAP 1972
+ G + ++N+K+ + + A N G P+ S+ + VPS P
Sbjct: 1039 IVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSE-INATTLEDVPSQPPEN 1096
Query: 1973 LEIRMVGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDV-TKTMWMEVGKVDVNTLKFNIRD 2030
+ + S++ + SW P L GY + + W E+ + + +R
Sbjct: 1097 VRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRG 1156
Query: 2031 LSENHTYMIRIYARNEIG 2048
+ + Y +++ A + G
Sbjct: 1157 MEKFTNYSVQVLAYTQAG 1174
Score = 90.6 bits (215), Expect = 5e-17
Identities = 157/749 (20%), Positives = 266/749 (35%), Gaps = 49/749 (6%)
Query: 651 ILLECRLVAIPEPDIAW-LFKGEEIVPDENIS-VAIESDMHMYCSVLKITNVKKFQEGTY 708
+++ C P + W L G++I +I V + +Y N + Y
Sbjct: 43 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFN-SFIHDNDY 101
Query: 709 TVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
A N G+ P + ++K +EP V +E +SM L V ++
Sbjct: 102 FCTAENAAGKIRSPNI-RVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 160
Query: 768 WCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
W K+ P G + + K + T + E A ++V +
Sbjct: 161 WEKDTVSIIPENRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 220
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P E P ++ F V T++L + P+P+I W ++ + T+
Sbjct: 221 PAESI---PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 277
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKS-SHGARVTIDVEKVTFVKHLQKSYETEEG 943
G L I+++ +E DSG Y C +N+ G + + G + ID VT K +T G
Sbjct: 278 G----LTISDLRTE-DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTP---KKLKTGIG 329
Query: 944 KTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
TVIL C S + +WY N E+ D I+ G +C
Sbjct: 330 STVILSCALTGSPEFTIRWYRNT-ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 388
Query: 1002 -KDQETS---TMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVVWERDGEII 1056
+ +T+ ++ +++ P + + V + +++ + V W D E I
Sbjct: 389 TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 448
Query: 1057 ----KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEI 1109
+ N+Y I + + + D G Y C R+ +AE V PP I
Sbjct: 449 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 508
Query: 1110 ITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDC 1168
++N G + ++W+KD + NH Q+ + KL
Sbjct: 509 -RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLP-DNHRQVVFENGTLKLTDVQK 566
Query: 1169 DLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL----TVEIPDET 1224
+D+ GEY C V +I ++ + F PA+ L V D
Sbjct: 567 GMDE-GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMP 625
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE-V 1283
+ +TW K VI T+ S +L I + YTC+ +A +T + + +
Sbjct: 626 IRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLI 685
Query: 1284 VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEW-IVNSKIIKKCKHTKPSIDS-- 1340
V PP+ V G L +P P W + H P
Sbjct: 686 VRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQ 745
Query: 1341 --KSASLTIKKVENTDAGIYKLRLENNCG 1367
++SL I+ V D G Y + N G
Sbjct: 746 ILPNSSLLIRHVLEEDIGYYLCQASNGVG 774
Score = 61.7 bits (143), Expect = 3e-08
Identities = 96/440 (21%), Positives = 167/440 (37%), Gaps = 36/440 (8%)
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI- 1678
NITT + +R E ++S + + A AG L + K P P ++ +
Sbjct: 1144 NITTTRERVELRGMEKFTNYSVQ--VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVP 1201
Query: 1679 -SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCE 1736
S SV + W PP G+ + KY I P + + + + Y I LN +
Sbjct: 1202 SSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1260
Query: 1737 YMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGG 1796
Y+ V A G + SE + I+ A P+ +V W +
Sbjct: 1261 YLLWVAAVTSAGRGNS--SEKVTIEPAGKAPAKIISFGG-------TVTTPWMKDVRLPC 1311
Query: 1797 SPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG----TSLPYT 1852
+ + D +K R+ + N T R + G T+
Sbjct: 1312 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRL--IHTNGTLLLRAVKAEDSGYYTCTATNTG 1369
Query: 1853 SDDKITIGKTL-TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS 1911
D I + + PP QPR VS++++ S+TL W P NGGS I +++++ +
Sbjct: 1370 GFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEE 1427
Query: 1912 WTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPS---P 1968
W K V + S ++++K +++A+N+VG S+ + + H PS
Sbjct: 1428 W-KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG--RISEIIEAKTHGREPSFSKD 1484
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNI 2028
I + + + W +GG P+ + R K W G ++ + +
Sbjct: 1485 QHLFTHINSTHARLNLQGWN----NGGCPITAIVLEYR--PKGTWAWQGLRANSSGEVFL 1538
Query: 2029 RDLSENHTYMIRIYARNEIG 2048
+L E Y +R+ A N G
Sbjct: 1539 TELREATWYELRMRACNSAG 1558
Score = 47.2 bits (107), Expect = 6e-04
Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 5/108 (4%)
Query: 499 EKPTSEEQSMAPIFVEKLRPK-HTPDGSTVQFECQVEGYPRPQITWFRQT--AIIKPSQD 555
EK T E AP + TP V+ C G P P + W + + + I S D
Sbjct: 1278 EKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD 1337
Query: 556 FQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ TL++R V ED+G +TC A N GF + L+V+ P
Sbjct: 1338 GHRLIHTNG--TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1383
Score = 45.6 bits (103), Expect = 0.002
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 4/92 (4%)
Query: 1964 TVPSPPTAP-LEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
TV PP P LEIR V + + W T +DG + + G++I ++ + + + +++
Sbjct: 883 TVQEPPDPPELEIREVKARSMNLRW-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNIS 941
Query: 2023 TL--KFNIRDLSENHTYMIRIYARNEIGLSEP 2052
+ NI DL Y IR+Y+ N+IG SEP
Sbjct: 942 PTINQANIVDLHPASVYSIRMYSFNKIGRSEP 973
Score = 44.8 bits (101), Expect = 0.003
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 5/95 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P ++ + G TV+ C GYP P I W + + + + L
Sbjct: 226 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK-----RITGLT 280
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
I ++ ED+GT+ C N G A +T L+V PL
Sbjct: 281 ISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 315
Score = 34.7 bits (76), Expect = 3.7
Identities = 25/100 (25%), Positives = 34/100 (34%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKP-SQDFQMYYDDDNVAT 567
P V K G C +G P P +TW I++ S Y D
Sbjct: 408 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 467
Query: 568 LVIREVFPE--DAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ P+ D G + C A+N G A + V P S
Sbjct: 468 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 507
>AB032958-1|BAA86446.2| 2092|Homo sapiens KIAA1132 protein protein.
Length = 2092
Score = 130 bits (314), Expect = 5e-29
Identities = 317/1535 (20%), Positives = 562/1535 (36%), Gaps = 164/1535 (10%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQIT---WFRQTAIIKPSQDFQMYYDDDNVATL 568
+ ++ + + G+ F+C + + ++ W + T I P F + Y L
Sbjct: 166 YTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPENRFFITYHGG----L 221
Query: 569 VIREVFPEDA-GTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
I +V EDA T+ C+ K+ ++ T + +G+ ++V D
Sbjct: 222 YISDVQKEDALSTYRCITKHK--YSGETRQ--------SNGARLSVT------------D 259
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
E IP T +Q V G + L C P P I WL G + D + I
Sbjct: 260 PAESIP-TILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG- 317
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
L I++++ GTY N G A +L + +P V K +
Sbjct: 318 -------LTISDLRTEDSGTYICEVTNTFGSAEATGILMV----IDPLHVTLTPKKLKTG 366
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYT 804
G +VILS + G+P TI W +N + V LP ++ G ++ ++ + G Y
Sbjct: 367 IGSTVILSCALTGSPEFTIRWYRNTELV--LPDEAISIRGLSNETLLITSAQKSHSGAYQ 424
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
A A+ A+I +E+ T P ++ F E V L+ P P++
Sbjct: 425 CFATRKAQTAQDFAIIALEDGT------PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTV 478
Query: 865 TWYRNNE-IISPSETITQNF---DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
TW ++E I+ T + DG I + D G Y+C A N G + + AR
Sbjct: 479 TWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQAR 538
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQE 978
I+V ++ + ++ G+ ++ C+ S KWY + + +HR+++ E
Sbjct: 539 --INVRGPPSIRAM-RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPD-NHRQVVFE 594
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVA-ILE 1037
D G C V Q ++ + +Q FE + +L
Sbjct: 595 -NGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLY 653
Query: 1038 VEINSETAD----VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
+ + D + W +DG++I + E + + L I + S+ G Y+CI +
Sbjct: 654 IPCVVSSGDMPIRITWRKDGQVI-ISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 712
Query: 1094 ESCTA---EVTVVELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS 1149
+ T +V +PP + + NQ G + V W
Sbjct: 713 AAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQ 772
Query: 1150 NHIQLTIDGKKQ-----KLKIYDCDLDDAGEYSCEVGNSKCTAI-----LTVEEPSINFT 1199
+ + + G+ Q L I +D G Y C+ N T I LTV+ P++ T
Sbjct: 773 QYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAM-IT 831
Query: 1200 LRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE--KFTLIS----DVKKRTL 1253
I + + + + + W K +VI+ ++ + + D TL
Sbjct: 832 SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTL 891
Query: 1254 IIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQ 1312
++ D ++C +++ + +++ V+ PP E E R + + L Q
Sbjct: 892 KLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD--PPELEIREVKARSMNLRWT-Q 948
Query: 1313 AFPQPNDEWIVNSKIIKKCKHTKPSI--DSKSASLTIKKVENTD---AGIYKLRLE--NN 1365
F + I I K K +++ S TI + D A +Y +R+ N
Sbjct: 949 RF--DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1006
Query: 1366 CGHADVEMNVTI-LDKPSPPGKP---NILEIDSSSINICWDEP-ENTGNSTIIYYVVEYQ 1420
G ++ +TI ++ +P G P + + S SI + W P + N I Y + Y+
Sbjct: 1007 IGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYR 1066
Query: 1421 EID--TTEWISVKNITKTQTS----IQNLKTNSSYRFRAYAVNEVDISDASE-----TTE 1469
E + S+ + T S + NLK + Y A N +S T E
Sbjct: 1067 ENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLE 1126
Query: 1470 YYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY 1529
+++ ++ + I+ L + G + Y DG+ + T
Sbjct: 1127 DVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNIT- 1185
Query: 1530 ENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK----QKHK 1585
R + +A+ G+ S V+ IQ K + IK
Sbjct: 1186 TTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASS 1245
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKN-GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
V WL G+ I+ + G+ EY T + RI L R
Sbjct: 1246 VVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYE--TSPEQLFYRIAHLNRGQQYLLW 1303
Query: 1645 IEASNTA--GTSSVEVTLKVYDKPSKPEGPVIMREIS-RESVTIEW----KPPLDDGGLE 1697
+ A +A G SS +VT+ +P G + IS +VT W + P + G
Sbjct: 1304 VAAVTSAGRGNSSEKVTI-------EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDP 1356
Query: 1698 LTKYAIEKHEPDNNRWIKVADVDRDVE---TYCIQKLNENCEYMFRVIAQNPVGFSEALE 1754
K D+ + + D R + T ++ + + A N GF
Sbjct: 1357 APAVKWTKDSEDSAIPVSM-DGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGF----- 1410
Query: 1755 SEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKW 1813
+ I++ + VP S+ +TW P + NGGS I + ++ ++W
Sbjct: 1411 -DTIIVNLLVQVPPDQPRLTVSKT-SASSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEW 1467
Query: 1814 KXXXXXXXXXA-RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNF 1872
K + ++ L T Y+ ++ A+N +G+ + T G+ + F
Sbjct: 1468 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLF 1527
Query: 1873 VVSESTSRSVTLK-WTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIK 1931
ST + L+ W +NGG PIT ++E++ KG +W S E + ++
Sbjct: 1528 THINSTHARLNLQGW----NNGGCPITAIVLEYRP-KG-TWAWQGLRANSSGEVFLTELR 1581
Query: 1932 EKDEIIFRISAENTVGVSLPTESQSVRLEKHATVP 1966
E R+ A N+ G T + +T+P
Sbjct: 1582 EATWYELRMRACNSAGCGNETAQFATLDYDGSTIP 1616
Score = 122 bits (294), Expect = 1e-26
Identities = 222/1098 (20%), Positives = 419/1098 (38%), Gaps = 124/1098 (11%)
Query: 1022 KLQDFEVKEKDVAILEVEINSETADVV----WERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
+++D +VA+ + I S + V WE+D I P+ N++ G LYI
Sbjct: 169 RVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPE-NRFFITYHGG---LYIS 224
Query: 1078 NTSVHDE-GEYSCILRD-------ESCTAEVTVV---ELPPEIITRLQNQKVNKGNKATF 1126
+ D Y CI + +S A ++V E P I+ +Q+V G+ T
Sbjct: 225 DVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGH--TV 282
Query: 1127 EIELTKGD---ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV--- 1180
E+ T +RW KDG + + I G L I D +D+G Y CEV
Sbjct: 283 ELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYICEVTNT 338
Query: 1181 -GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET-LDVTWYKKKSVIED 1238
G+++ T IL V +P ++ TL P+ + + L+ + + WY+ ++
Sbjct: 339 FGSAEATGILMVIDP-LHVTLT-PKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLP 396
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFPPKIVDYERE 1296
E + I + TL+I + Y C T + + + + P+IV E
Sbjct: 397 DEAIS-IRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSE 455
Query: 1297 YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT--- 1353
+ G +L+ + P P W ++ + I + + + + S TI + T
Sbjct: 456 KVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQ 515
Query: 1354 --DAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
D G+Y+ N G A+ + + + PS NI + I N
Sbjct: 516 IRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLI------NCRVIG 569
Query: 1412 IIYYVVE-YQEI----DTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
YY ++ Y++ D + +N T T +Q Y ++ IS +
Sbjct: 570 YPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVH 629
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQP-KVTWYRDGKKLKTA 1525
++ P + +P + + + + C+ P ++TW +DG+ + +
Sbjct: 630 VA----------VKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISG 679
Query: 1526 KA-TYENRXXXXXXXXXXXXXXX---YKCIAFNDHGEV--ETSCVVGIQQKPVITISNED 1579
T E++ Y CIA N V E +V + + V+ +N+D
Sbjct: 680 SGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQD 739
Query: 1580 IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN---ITTKEK---TSVIRIK 1633
G ++ ++G PPP+V+W K+ N ++Y+ +T + + S + I+
Sbjct: 740 ----GIYGKAGVLNCSVDGYPPPKVMW-KHAKGSGNPQQYHPVPLTGRIQILPNSSLLIR 794
Query: 1634 ELKRSHSSKYTIEASNTAGTS---SVEVTLKVYDK-PSKPEGPVIMREISRE-SVTIEWK 1688
+ Y +ASN GT S+ +T+K+ S P + ++ ++E + T +
Sbjct: 795 HVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGE 854
Query: 1689 PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD-----VETYCIQKLNENCEYMFRVIA 1743
P+ + ++ D +R ++ A +D V T ++ + F A
Sbjct: 855 RPI------IIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHA 908
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
N G L + ++ D P + S+ + W +G S I +
Sbjct: 909 INSYGEDRGLIQ--LTVQEPPDPPELEIRE-----VKARSMNLRW-TQRFDGNSIITGFD 960
Query: 1804 VEIKQEGKKWKXXXXXXXXXARIQKLSI-----NTTYQFRIYARNEIGTSLPYTSDDKIT 1858
+E K + W I + +I + Y R+Y+ N+IG S P ++T
Sbjct: 961 IEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEP---SKELT 1017
Query: 1859 IG-KTLTPPSQPRNFVVSESTSRSVTLKWTEPESN-GGSPITNYIIEFKT----VKGKSW 1912
I + P P + + TS+S+ + W P+ I Y I ++ G+
Sbjct: 1018 ISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYS 1077
Query: 1913 TKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAP 1972
+ G + ++N+K+ + + A N G P+ S+ + VPS P
Sbjct: 1078 IVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSE-INATTLEDVPSQPPEN 1135
Query: 1973 LEIRMVGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDV-TKTMWMEVGKVDVNTLKFNIRD 2030
+ + S++ + SW P L GY + + W E+ + + +R
Sbjct: 1136 VRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRG 1195
Query: 2031 LSENHTYMIRIYARNEIG 2048
+ + Y +++ A + G
Sbjct: 1196 MEKFTNYSVQVLAYTQAG 1213
Score = 90.6 bits (215), Expect = 5e-17
Identities = 157/749 (20%), Positives = 266/749 (35%), Gaps = 49/749 (6%)
Query: 651 ILLECRLVAIPEPDIAW-LFKGEEIVPDENIS-VAIESDMHMYCSVLKITNVKKFQEGTY 708
+++ C P + W L G++I +I V + +Y N + Y
Sbjct: 82 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFN-SFIHDNDY 140
Query: 709 TVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
A N G+ P + ++K +EP V +E +SM L V ++
Sbjct: 141 FCTAENAAGKIRSPNI-RVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 199
Query: 768 WCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
W K+ P G + + K + T + E A ++V +
Sbjct: 200 WEKDTVSIIPENRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 259
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P E P ++ F V T++L + P+P+I W ++ + T+
Sbjct: 260 PAESI---PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 316
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKS-SHGARVTIDVEKVTFVKHLQKSYETEEG 943
G L I+++ +E DSG Y C +N+ G + + G + ID VT K +T G
Sbjct: 317 G----LTISDLRTE-DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTP---KKLKTGIG 368
Query: 944 KTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
TVIL C S + +WY N E+ D I+ G +C
Sbjct: 369 STVILSCALTGSPEFTIRWYRNT-ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 427
Query: 1002 -KDQETS---TMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVVWERDGEII 1056
+ +T+ ++ +++ P + + V + +++ + V W D E I
Sbjct: 428 TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPI 487
Query: 1057 ----KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEI 1109
+ N+Y I + + + D G Y C R+ +AE V PP I
Sbjct: 488 VRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI 547
Query: 1110 ITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDC 1168
++N G + ++W+KD + NH Q+ + KL
Sbjct: 548 -RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLP-DNHRQVVFENGTLKLTDVQK 605
Query: 1169 DLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL----TVEIPDET 1224
+D+ GEY C V +I ++ + F PA+ L V D
Sbjct: 606 GMDE-GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMP 664
Query: 1225 LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE-V 1283
+ +TW K VI T+ S +L I + YTC+ +A +T + + +
Sbjct: 665 IRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLI 724
Query: 1284 VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEW-IVNSKIIKKCKHTKPSIDS-- 1340
V PP+ V G L +P P W + H P
Sbjct: 725 VRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQ 784
Query: 1341 --KSASLTIKKVENTDAGIYKLRLENNCG 1367
++SL I+ V D G Y + N G
Sbjct: 785 ILPNSSLLIRHVLEEDIGYYLCQASNGVG 813
Score = 61.7 bits (143), Expect = 3e-08
Identities = 96/440 (21%), Positives = 167/440 (37%), Gaps = 36/440 (8%)
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI- 1678
NITT + +R E ++S + + A AG L + K P P ++ +
Sbjct: 1183 NITTTRERVELRGMEKFTNYSVQ--VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVP 1240
Query: 1679 -SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCE 1736
S SV + W PP G+ + KY I P + + + + Y I LN +
Sbjct: 1241 SSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1299
Query: 1737 YMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGG 1796
Y+ V A G + SE + I+ A P+ +V W +
Sbjct: 1300 YLLWVAAVTSAGRGNS--SEKVTIEPAGKAPAKIISFGG-------TVTTPWMKDVRLPC 1350
Query: 1797 SPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG----TSLPYT 1852
+ + D +K R+ + N T R + G T+
Sbjct: 1351 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRL--IHTNGTLLLRAVKAEDSGYYTCTATNTG 1408
Query: 1853 SDDKITIGKTL-TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS 1911
D I + + PP QPR VS++++ S+TL W P NGGS I +++++ +
Sbjct: 1409 GFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEE 1466
Query: 1912 WTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPS---P 1968
W K V + S ++++K +++A+N+VG S+ + + H PS
Sbjct: 1467 W-KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG--RISEIIEAKTHGREPSFSKD 1523
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNI 2028
I + + + W +GG P+ + R K W G ++ + +
Sbjct: 1524 QHLFTHINSTHARLNLQGWN----NGGCPITAIVLEYR--PKGTWAWQGLRANSSGEVFL 1577
Query: 2029 RDLSENHTYMIRIYARNEIG 2048
+L E Y +R+ A N G
Sbjct: 1578 TELREATWYELRMRACNSAG 1597
Score = 47.2 bits (107), Expect = 6e-04
Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 5/108 (4%)
Query: 499 EKPTSEEQSMAPIFVEKLRPK-HTPDGSTVQFECQVEGYPRPQITWFRQT--AIIKPSQD 555
EK T E AP + TP V+ C G P P + W + + + I S D
Sbjct: 1317 EKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD 1376
Query: 556 FQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ TL++R V ED+G +TC A N GF + L+V+ P
Sbjct: 1377 GHRLIHTNG--TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1422
Score = 45.6 bits (103), Expect = 0.002
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 4/92 (4%)
Query: 1964 TVPSPPTAP-LEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
TV PP P LEIR V + + W T +DG + + G++I ++ + + + +++
Sbjct: 922 TVQEPPDPPELEIREVKARSMNLRW-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNIS 980
Query: 2023 TL--KFNIRDLSENHTYMIRIYARNEIGLSEP 2052
+ NI DL Y IR+Y+ N+IG SEP
Sbjct: 981 PTINQANIVDLHPASVYSIRMYSFNKIGRSEP 1012
Score = 44.8 bits (101), Expect = 0.003
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 5/95 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P ++ + G TV+ C GYP P I W + + + + L
Sbjct: 265 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK-----RITGLT 319
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
I ++ ED+GT+ C N G A +T L+V PL
Sbjct: 320 ISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 354
Score = 34.7 bits (76), Expect = 3.7
Identities = 25/100 (25%), Positives = 34/100 (34%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKP-SQDFQMYYDDDNVAT 567
P V K G C +G P P +TW I++ S Y D
Sbjct: 447 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 506
Query: 568 LVIREVFPE--DAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ P+ D G + C A+N G A + V P S
Sbjct: 507 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 546
>AL353593-2|CAI19284.1| 416|Homo sapiens obscurin, cytoskeletal
calmodulin and titin-interacting RhoGEF protein.
Length = 416
Score = 129 bits (312), Expect = 9e-29
Identities = 104/390 (26%), Positives = 164/390 (42%), Gaps = 13/390 (3%)
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDV 1033
EI +GR D G+++ TS L V+ F++ L D +E+
Sbjct: 10 EISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGT 69
Query: 1034 AILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRD 1093
L+ E++ A VVW +DG + P +KYDF R L + + S D G Y+C +
Sbjct: 70 LALQCEVSDPEAHVVWRKDGVQLGP-SDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGS 128
Query: 1094 ESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNH 1151
E A V V +L I RL+ +V +G +FE L+ A W G + S+
Sbjct: 129 EETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSR 188
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPAN 1211
Q T G+K L + + DAGE V A L V E L + + P
Sbjct: 189 FQATRQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGE 248
Query: 1212 TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
D L E+ V W K + I ++K+ ++ + L+IR + D EYTC +
Sbjct: 249 -DVELRCELSRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVE 307
Query: 1272 DAKSTTKLKVEVVE--FPPKIVDYEREYRIKRGSDV-TLLVDYQAFPQPNDEWIVNSKII 1328
+KST L VE F ++ + + E ++G+ V T ++ P W +
Sbjct: 308 ASKSTASLHVEEKANCFTEELTNLQVE---EKGTAVFTCKTEH---PAATVTWRKGLLEL 361
Query: 1329 KKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
+ +PS + + LTI +E D+ Y
Sbjct: 362 RASGKHQPSQEGLTLRLTISALEKADSDTY 391
Score = 123 bits (296), Expect = 8e-27
Identities = 105/393 (26%), Positives = 163/393 (41%), Gaps = 7/393 (1%)
Query: 893 TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT 952
T V I D V ++S K S AR+ + V+ V F+K L EE T+ L+C+
Sbjct: 19 TLVLKSIQRADAGIVRASSL-KVSTSARLEVRVKPVVFLKALD-DLSAEERGTLALQCEV 76
Query: 953 SHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLV 1011
S + W + ++ D + + D G+ C V +ET +
Sbjct: 77 SDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVR 136
Query: 1012 VKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD--VVWERDGEIIKPKKNKYDFEKRG 1069
V + ++L+ EV E + E ++ E+A +W G+ + +++ ++G
Sbjct: 137 VHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVG-SSSRFQATRQG 195
Query: 1070 HIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
L +R + D GE +R + A + V E P II L++Q V G E
Sbjct: 196 RKYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCE 255
Query: 1130 LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAIL 1189
L++ V W KD I+ S + +G L I L DAGEY+CEV SK TA L
Sbjct: 256 LSRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKSTASL 315
Query: 1190 TVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVK 1249
VEE + FT L + V A T + VTW K + + K +
Sbjct: 316 HVEEKANCFTEELTN-LQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGL 374
Query: 1250 KRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
L I + D YTC + A+S +L V+
Sbjct: 375 TLRLTISALEKADSDTYTCDIGQAQSRAQLLVQ 407
Score = 72.9 bits (171), Expect = 1e-11
Identities = 64/303 (21%), Positives = 120/303 (39%), Gaps = 6/303 (1%)
Query: 1063 YDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGN 1122
++ +G L +++ D G S +A + V P + L + +
Sbjct: 9 HEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERG 68
Query: 1123 KATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ E++ +A V W KDG ++ S+ + L ++D +DAG Y+C VG+
Sbjct: 69 TLALQCEVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGS 128
Query: 1183 SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDTEK 1241
+ A + V + + T RL ++ + ++ V + D W + + +
Sbjct: 129 EETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSR 188
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS-TTKLKVEVVEFPPKIVDYEREYRIK 1300
F +K L++R+ D E V+ + T+K + V E P I+ + +
Sbjct: 189 FQATRQGRKYILVVREAAPSDAGE---VVFSVRGLTSKASLIVRERPAAIIKPLEDQWVA 245
Query: 1301 RGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKL 1360
G DV L + P W+ + K I+K + + A L I+ DAG Y
Sbjct: 246 PGEDVELRCELSRAGTP-VHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTC 304
Query: 1361 RLE 1363
+E
Sbjct: 305 EVE 307
Score = 52.0 bits (119), Expect = 2e-05
Identities = 45/178 (25%), Positives = 81/178 (45%), Gaps = 17/178 (9%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD---GDTHS 788
+ P +I+PL+ V GE V L ++ P + W K+ K ++ K D T +
Sbjct: 230 ERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRK-SQKYDVVCEGTMA 287
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+ +++ +KD G YT + E S +++A + VEE F + V+EKG
Sbjct: 288 MLVIRGASLKDAGEYTCEVEAS----KSTASLHVEEKAN------CFTEELTNLQVEEKG 337
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
T + T +P ++TW + + S + +G + L I+ ++ + DS Y C
Sbjct: 338 TAVFTCK-TEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALE-KADSDTYTC 393
Score = 39.1 bits (87), Expect = 0.17
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F++ L + T+ +C+V P + W + + PS + + LV+
Sbjct: 54 VFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTA-GTRGLVV 111
Query: 571 REVFPEDAGTFTC 583
+V PEDAG +TC
Sbjct: 112 HDVSPEDAGLYTC 124
Score = 36.7 bits (81), Expect = 0.91
Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 2/85 (2%)
Query: 513 VEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
++ L + G V+ C++ P + W + I+ SQ + + + +A LVIR
Sbjct: 236 IKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQKYDVVCEG-TMAMLVIRG 293
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTE 597
+DAG +TC + + AS E
Sbjct: 294 ASLKDAGEYTCEVEASKSTASLHVE 318
>AJ314903-1|CAC85750.1| 542|Homo sapiens obscurin protein.
Length = 542
Score = 128 bits (309), Expect = 2e-28
Identities = 121/541 (22%), Positives = 223/541 (41%), Gaps = 23/541 (4%)
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTL 805
G S +LS +V + + W K+ K + + + ++ G T + + + + D G Y+
Sbjct: 18 GTSTMLSCEVA-QAQTEVMWYKDGKKLSSSSKMRVEAVGCTRRLVVQEAGQA-DAGEYSC 75
Query: 806 KAENSEGIAETSAVITVEEPTEENA-EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
+A G S + V EP A E P +E+ + + L V + + +
Sbjct: 76 EA----GGQRLSFHLHVAEPKVVFAKEQPAC----REVQAEAGASATLSCEVAQGQM-EV 126
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
TWY++ + +S S + G LV+ + D+G+Y C A + S V
Sbjct: 127 TWYKDGKKLSSSSKVHMEASGYTRRLVVQQA-GQADAGEYSCEAGGQ--RLSFRLHVAEL 183
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREIIQEGRXX 982
+++ ++ +E + +IL T + W + EI E +G
Sbjct: 184 EPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTH 243
Query: 983 XXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS 1042
D + C V + + V+E +F R L+ + L E++
Sbjct: 244 TLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSP 303
Query: 1043 ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
A+VVW ++ K ++ G +R L + D GEY C RD+ +A++TV
Sbjct: 304 ACAEVVWRCGNTQLRVGK-RFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTV 362
Query: 1103 -VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
V + ++ L +G +ATF+ ++ D V WF+DG+ +Q S ++ G
Sbjct: 363 SVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSGASH 422
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP 1221
L I D L+DAG+ + E + +A L V E + F +L E V + L VE+
Sbjct: 423 SLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKL-EPQTVEERSSVTLEVELT 481
Query: 1222 DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
++ W + + + + + ++ + L++ D+ + C D K+ KL V
Sbjct: 482 RAWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKLTV 541
Query: 1282 E 1282
E
Sbjct: 542 E 542
Score = 124 bits (299), Expect = 4e-27
Identities = 117/522 (22%), Positives = 203/522 (38%), Gaps = 20/522 (3%)
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
E GT +++ + WY++ + +S S + G LV+ + D+G+Y
Sbjct: 16 EAGTSTMLSCEVAQAQTEVMWYKDGKKLSSSSKMRVEAVGCTRRLVVQEA-GQADAGEYS 74
Query: 906 CVASNSAGKSSHGARVTIDVEKVTFVKHLQ--KSYETEEGKTVILECQTSH-TVSTKWYH 962
C AG + + KV F K + + E G + L C+ + + WY
Sbjct: 75 C----EAGGQRLSFHLHVAEPKVVFAKEQPACREVQAEAGASATLSCEVAQGQMEVTWYK 130
Query: 963 NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRK 1022
+ K++S + G D G C Q S L V E P+ +
Sbjct: 131 DGKKLSSSSKVHMEASGYTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHVAELEPQISER 190
Query: 1023 ---LQDFEVKEKDVAILEVEINSETA-DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRN 1078
+ VKE + IL + + +A V W +DG I+ K +++ +G L +
Sbjct: 191 PCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSK-RHETASQGDTHTLTVHG 249
Query: 1079 TSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR 1138
V D YSC + E V V E+ + L+ G T EL+ A V
Sbjct: 250 AQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRLLEPVCGELGGTVTLACELSPACAEVV 309
Query: 1139 WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPS-IN 1197
W ++++ Q+ +G + L + +DAGEY CE + +A LTV P +
Sbjct: 310 WRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVK 369
Query: 1198 FTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRK 1257
F L + + V P + + V W++ ++++ +EKF + +L I
Sbjct: 370 FMSGLSTVVAEEGGEATFQCVVSPSD-VAVVWFRDGALLQPSEKFAISQSGASHSLTISD 428
Query: 1258 CTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDY-QAFPQ 1316
+D + T A S+ L+V E P ++ S VTL V+ +A+P+
Sbjct: 429 LVLEDAGQITVEAEGASSSAALRVR--EAPVLFKKKLEPQTVEERSSVTLEVELTRAWPE 486
Query: 1317 PNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIY 1358
W N+ + K+ + + L + V D G +
Sbjct: 487 L--RWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFF 526
Score = 116 bits (280), Expect = 7e-25
Identities = 121/552 (21%), Positives = 220/552 (39%), Gaps = 30/552 (5%)
Query: 646 DEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE 705
+ G+ +L C VA + ++ W G+++ + V L + +
Sbjct: 16 EAGTSTMLSCE-VAQAQTEVMWYKDGKKLSSSSKMRVEAVGCTRR----LVVQEAGQADA 70
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G Y+ A + L + KE P E + G S LS +V +
Sbjct: 71 GEYSCEAGGQRLSFHLHVAEPKVVFAKEQPACRE----VQAEAGASATLSCEVAQG-QME 125
Query: 766 ITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+TW K+ K + + + ++ G T + + + + D G Y+ +A G S + V
Sbjct: 126 VTWYKDGKKLSSSSKVHMEASGYTRRLVVQQAGQA-DAGEYSCEA----GGQRLSFRLHV 180
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E + +E P R + + VKE I L A + ++TW ++ I S+
Sbjct: 181 AELEPQISERPC---RREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETA 237
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
G+ L + +DS Y C G V ++ F + L+ E
Sbjct: 238 SQGDTHTLTVHGAQV-LDSAIYSC----RVGAEGQDFPVQVEEVAAKFCRLLEPVCG-EL 291
Query: 943 GKTVILECQTSHTVS-TKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
G TV L C+ S + W ++ +++ EG D G C
Sbjct: 292 GGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCES 351
Query: 1002 KDQETSTMLVVK-ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKK 1060
+D TS L V + +F+ L +E A + ++ VVW RDG +++P +
Sbjct: 352 RDDHTSAQLTVSVPRVVKFMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSE 411
Query: 1061 NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNK 1120
K+ + G L I + + D G+ + S +A + V E P +L+ Q V +
Sbjct: 412 -KFAISQSGASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVEE 470
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
+ T E+ELT+ +RW ++ + + ++++ +G + +L +++ D G + CE
Sbjct: 471 RSSVTLEVELTRAWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCET 530
Query: 1181 GNSKCTAILTVE 1192
+ K A LTVE
Sbjct: 531 PDDKTQAKLTVE 542
Score = 93.9 bits (223), Expect = 6e-18
Identities = 59/247 (23%), Positives = 108/247 (43%), Gaps = 7/247 (2%)
Query: 1121 GNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
G E+ + V W+KDG ++ S+ +++ G ++L + + DAGEYSCE
Sbjct: 18 GTSTMLSCEVAQAQTEVMWYKDGKKLSSSSKMRVEAVGCTRRLVVQEAGQADAGEYSCEA 77
Query: 1181 GNSKCTAILTVEEPSINFTLRLP--EFILVPANTDAYLTVEIPDETLDVTWYKKKSVIED 1238
G + + L V EP + F P + A A L+ E+ ++VTWYK +
Sbjct: 78 GGQRLSFHLHVAEPKVVFAKEQPACREVQAEAGASATLSCEVAQGQMEVTWYKDGKKLSS 137
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVD--YERE 1296
+ K + + R L++++ + D EY+C ++ V E P+I + RE
Sbjct: 138 SSKVHMEASGYTRRLVVQQAGQADAGEYSCEA--GGQRLSFRLHVAELEPQISERPCRRE 195
Query: 1297 -YRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDA 1355
+K D+ L W+ + I++ K + + + +LT+ + D+
Sbjct: 196 PLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDS 255
Query: 1356 GIYKLRL 1362
IY R+
Sbjct: 256 AIYSCRV 262
Score = 65.3 bits (152), Expect = 2e-09
Identities = 87/388 (22%), Positives = 156/388 (40%), Gaps = 34/388 (8%)
Query: 632 IPPTFSKKP---KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
+ P S++P + V E DI+L L + WL G EI + A + D
Sbjct: 183 LEPQISERPCRREPLVVKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDT 242
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
H L + + Y+ V EG+ P+ +++ + +++EP+ +
Sbjct: 243 H----TLTVHGAQVLDSAIYS-CRVGAEGQ-DFPV--QVEEVAAKFCRLLEPVCGEL--- 291
Query: 749 GESVILSAQVVGNPRPTITWCKNN--KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G +V L+ ++ + C N + K ++G S+T+L + +D G Y +
Sbjct: 292 GGTVTLACELSPACAEVVWRCGNTQLRVGKRFQMVAEGPVRSLTVL-GLRAEDAGEYVCE 350
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
+ + TSA +TV P F++ + +E G V+ + V ++ W
Sbjct: 351 SRDD----HTSAQLTVSVPRVVK-----FMSGLSTVVAEEGGEATFQCVVSPSDV-AVVW 400
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+R+ ++ PSE + G + L I+++ E D+G + + G SS A + +
Sbjct: 401 FRDGALLQPSEKFAISQSGASHSLTISDLVLE-DAGQ---ITVEAEGASS-SAALRVREA 455
Query: 927 KVTFVKHLQKSYETEEGKTVILECQ-TSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
V F K L+ EE +V LE + T +W N ++ + EI EG
Sbjct: 456 PVLFKKKLEPQ-TVEERSSVTLEVELTRAWPELRWTRNATALAPGKNVEIHAEGARHRLV 514
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVK 1013
D G C D +T L V+
Sbjct: 515 LHNVGFADRGFFGCETPDDKTQAKLTVE 542
Score = 37.5 bits (83), Expect = 0.52
Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F+ L +G F+C V + WFR A+++PS+ F + + +L I
Sbjct: 370 FMSGLSTVVAEEGGEATFQCVVSPSD-VAVVWFRDGALLQPSEKFAISQSGAS-HSLTIS 427
Query: 572 EVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
++ EDAG T A G +SS + EAP+
Sbjct: 428 DLVLEDAGQITV---EAEGASSSAALRVREAPV 457
>BC048768-1|AAH48768.1| 1898|Homo sapiens protein tyrosine
phosphatase, receptor type, F protein.
Length = 1898
Score = 128 bits (308), Expect = 3e-28
Identities = 211/1007 (20%), Positives = 386/1007 (38%), Gaps = 85/1007 (8%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTID-GKKQKLK 1164
P I ++Q G A+F + T + + W K G ++ + D G L+
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLR 92
Query: 1165 IYDCDLD-DAGEYSCEVGNS----KCTAILTVEE--------PSINFTLRLPEFILVPAN 1211
I + D Y C NS +A L+V E PSI+ +L ++ A
Sbjct: 93 IQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLK--VVEKAR 150
Query: 1212 TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
T L + +++W+K ++ I ++ L I E DQ +Y CV
Sbjct: 151 TATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVAT 210
Query: 1272 DAKST-----TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
++ T L V V P+ + G V L P P +W++ ++
Sbjct: 211 NSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAE 270
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
+ K + S ++ T I L G + VT+ P PP
Sbjct: 271 ELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL------GMIEATAQVTVKALPKPPID 324
Query: 1387 PNILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTT-EWISVKNITKTQTSIQNLK 1444
+ E ++S+ + WD +GNS + YY ++Y+ T + V + T+ SI L
Sbjct: 325 LVVTETTATSVTLTWD----SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLS 380
Query: 1445 TNSSYRFRAYAVNEVDISDASE-----TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDI 1499
S Y FR AVN + SE T E ++Q+ + + EP E+
Sbjct: 381 PFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEP 440
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHG 1557
G V +V + D ++ A + Y + +AF G
Sbjct: 441 N-----GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVG 495
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE-VIWYKNGN-KLEN 1615
+ S + ++ + + D Q D + + + +PP E +I Y+ E+
Sbjct: 496 DGPPSPTIQVKTQQGVPAQPADF-QAEVESDTRIQLSWL--LPPQERIIMYELVYWAAED 552
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP--- 1672
+ + + T + TS +++LK ++ + A + G T++ S P P
Sbjct: 553 EDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQK 612
Query: 1673 VIMREISRESVTIEW-KPPLDDGGLELTKYAIEKHEPD-NNRWIKVAD-VDRDVETYCIQ 1729
V+ + +V + W PP D +T+Y++ D +R V D + R+ ++ +
Sbjct: 613 VMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLV 672
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW- 1788
L + EY V A VG ES P++++T DVPS +++ +V++ W
Sbjct: 673 GLEKWTEYRVWVRAHTDVG--PGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWK 730
Query: 1789 --FPSEKNGGSPIIDYKVEI--KQEGKKWKXXXXXXXXXARIQKLSIN-----TTYQFRI 1839
PS+++G I Y+V + G+ A Q+ +I+ TTY +
Sbjct: 731 LPVPSKQHG--QIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTV 788
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A G S KI + T P +P ++S + + L+W P+ G +
Sbjct: 789 AAYTTKGDGA--RSKPKI-VTTTGAVPGRP-TMMISTTAMNTALLQWHPPKELPGE-LLG 843
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
Y +++ ++ + G + + + IFR++A+N G+ E + +
Sbjct: 844 YRLQYCRA-DEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE---I 899
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW-DGGAPLLGYNIAIRDVTKTMWMEVGK 2018
+PS L + + ++ +W P + ++ Y + RD+ E+
Sbjct: 900 RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ--QELQN 957
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGE 2065
+ +T +F + L + TY I++ A G S PL + +P E
Sbjct: 958 ITTDT-RFTLTGLKPDTTYDIKVRAWTSKG-SGPLSPSIQSRTMPVE 1002
Score = 73.3 bits (172), Expect = 9e-12
Identities = 80/301 (26%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F K P+ Q G C+ P+P I W+ KG++ V + V IE D S
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKK-VSSQRFEV-IEFD-DGAGS 89
Query: 694 VLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQG 749
VL+I ++ + E Y A N GE + L + E+ P P + + +V +
Sbjct: 90 VLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKA 149
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYTL 805
+ + GNP P I+W K+ PV P S+G + ++ + D+G Y
Sbjct: 150 RTATMLCAAGGNPDPEISWFKDFLPVD--PATSNGRIKQLRSGALQIESSEESDQGKYEC 207
Query: 806 KAENSEGI---AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
A NS G A + + V + PP QE V G++ L P+P
Sbjct: 208 VATNSAGTRYSAPANLYVRVRRVAPRFSIPP----SSQE--VMPGGSVNLTCVAVGAPMP 261
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W E ++ + + G N+ L ++NV + S +Y CVA +S G A+VT
Sbjct: 262 YVKWMMGAEELTKEDEMPV---GRNV-LELSNV---VRSANYTCVAISSLGMIEATAQVT 314
Query: 923 I 923
+
Sbjct: 315 V 315
Score = 71.7 bits (168), Expect = 3e-11
Identities = 81/317 (25%), Positives = 130/317 (41%), Gaps = 36/317 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY-YDDDNVATL 568
P+F++ + G F CQ G P+P+ITW ++ + SQ F++ +DD + L
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVS-SQRFEVIEFDDGAGSVL 91
Query: 569 VIREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
I+ + D + C A N+ G E+ A LS E
Sbjct: 92 RIQPLRVQRDEAIYECTATNSLG------EINTSAKLSVLEEEQ---------------- 129
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ G P + P+ + V++ + C P+P+I+W FK V + I+
Sbjct: 130 LPPGFP-SIDMGPQLKVVEKARTATMLCAAGGNPDPEISW-FKDFLPVDPATSNGRIKQ- 186
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+ L+I + ++ +G Y VA N G S P L ++ P I P S V
Sbjct: 187 --LRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPP-SSQEV 243
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G SV L+ VG P P + W + + TK D +L+ V YT
Sbjct: 244 MPGGSVNLTCVAVGAPMPYVKWMMGAEEL----TKEDEMPVGRNVLELSNVVRSANYTCV 299
Query: 807 AENSEGIAETSAVITVE 823
A +S G+ E +A +TV+
Sbjct: 300 AISSLGMIEATAQVTVK 316
Score = 64.5 bits (150), Expect = 4e-09
Identities = 62/254 (24%), Positives = 103/254 (40%), Gaps = 18/254 (7%)
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPSKPEGPVIM-REISRESVTIEWKPPLDDGGLELTKYA 1702
T+ A T G + V + P P +M + + ++W PP + G EL Y
Sbjct: 787 TVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPG-ELLGYR 845
Query: 1703 IEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT 1762
++ D R D +D + + + L++ Y+FR+ A+N G E E E I+T
Sbjct: 846 LQYCRADEAR-PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE---IRT 901
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKVEIKQEGKKWKXXXXX 1819
D+PS + + + W P +E+NG II Y V + + +
Sbjct: 902 PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG--RIISYTVVFRDINSQQELQNIT 959
Query: 1820 XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQ--PRNFVVSES 1877
+ L +TTY ++ A G+ P + +I P Q +NF V+ +
Sbjct: 960 TDTRFTLTGLKPDTTYDIKVRAWTSKGSG-PLSP----SIQSRTMPVEQVFAKNFRVAAA 1014
Query: 1878 TSRSVTLKWTEPES 1891
SV L W P+S
Sbjct: 1015 MKTSVLLSWEVPDS 1028
Score = 43.2 bits (97), Expect = 0.010
Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 10/107 (9%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FS P +Q V G + L C V P P + W+ EE+ E +M +
Sbjct: 230 VAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTK--------EDEMPVG 281
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+VL+++NV + YT VA++ G + +K K P ++
Sbjct: 282 RNVLELSNV--VRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLV 326
>AL583862-9|CAI14895.1| 1898|Homo sapiens protein tyrosine
phosphatase, receptor type, F protein.
Length = 1898
Score = 128 bits (308), Expect = 3e-28
Identities = 211/1007 (20%), Positives = 386/1007 (38%), Gaps = 85/1007 (8%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTID-GKKQKLK 1164
P I ++Q G A+F + T + + W K G ++ + D G L+
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLR 92
Query: 1165 IYDCDLD-DAGEYSCEVGNS----KCTAILTVEE--------PSINFTLRLPEFILVPAN 1211
I + D Y C NS +A L+V E PSI+ +L ++ A
Sbjct: 93 IQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLK--VVEKAR 150
Query: 1212 TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
T L + +++W+K ++ I ++ L I E DQ +Y CV
Sbjct: 151 TATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVAT 210
Query: 1272 DAKST-----TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
++ T L V V P+ + G V L P P +W++ ++
Sbjct: 211 NSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAE 270
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
+ K + S ++ T I L G + VT+ P PP
Sbjct: 271 ELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL------GMIEATAQVTVKALPKPPID 324
Query: 1387 PNILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTT-EWISVKNITKTQTSIQNLK 1444
+ E ++S+ + WD +GNS + YY ++Y+ T + V + T+ SI L
Sbjct: 325 LVVTETTATSVTLTWD----SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLS 380
Query: 1445 TNSSYRFRAYAVNEVDISDASE-----TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDI 1499
S Y FR AVN + SE T E ++Q+ + + EP E+
Sbjct: 381 PFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEP 440
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHG 1557
G V +V + D ++ A + Y + +AF G
Sbjct: 441 N-----GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVG 495
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE-VIWYKNGN-KLEN 1615
+ S + ++ + + D Q D + + + +PP E +I Y+ E+
Sbjct: 496 DGPPSPTIQVKTQQGVPAQPADF-QAEVESDTRIQLSWL--LPPQERIIMYELVYWAAED 552
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP--- 1672
+ + + T + TS +++LK ++ + A + G T++ S P P
Sbjct: 553 EDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQK 612
Query: 1673 VIMREISRESVTIEW-KPPLDDGGLELTKYAIEKHEPD-NNRWIKVAD-VDRDVETYCIQ 1729
V+ + +V + W PP D +T+Y++ D +R V D + R+ ++ +
Sbjct: 613 VMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLV 672
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW- 1788
L + EY V A VG ES P++++T DVPS +++ +V++ W
Sbjct: 673 GLEKWTEYRVWVRAHTDVG--PGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWK 730
Query: 1789 --FPSEKNGGSPIIDYKVEI--KQEGKKWKXXXXXXXXXARIQKLSIN-----TTYQFRI 1839
PS+++G I Y+V + G+ A Q+ +I+ TTY +
Sbjct: 731 LPVPSKQHG--QIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTV 788
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A G S KI + T P +P ++S + + L+W P+ G +
Sbjct: 789 AAYTTKGDGA--RSKPKI-VTTTGAVPGRP-TMMISTTAMNTALLQWHPPKELPGE-LLG 843
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
Y +++ ++ + G + + + IFR++A+N G+ E + +
Sbjct: 844 YRLQYCRA-DEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE---I 899
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW-DGGAPLLGYNIAIRDVTKTMWMEVGK 2018
+PS L + + ++ +W P + ++ Y + RD+ E+
Sbjct: 900 RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ--QELQN 957
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGE 2065
+ +T +F + L + TY I++ A G S PL + +P E
Sbjct: 958 ITTDT-RFTLTGLKPDTTYDIKVRAWTSKG-SGPLSPSIQSRTMPVE 1002
Score = 73.3 bits (172), Expect = 9e-12
Identities = 80/301 (26%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F K P+ Q G C+ P+P I W+ KG++ V + V IE D S
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKK-VSSQRFEV-IEFD-DGAGS 89
Query: 694 VLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQG 749
VL+I ++ + E Y A N GE + L + E+ P P + + +V +
Sbjct: 90 VLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKA 149
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYTL 805
+ + GNP P I+W K+ PV P S+G + ++ + D+G Y
Sbjct: 150 RTATMLCAAGGNPDPEISWFKDFLPVD--PATSNGRIKQLRSGALQIESSEESDQGKYEC 207
Query: 806 KAENSEGI---AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
A NS G A + + V + PP QE V G++ L P+P
Sbjct: 208 VATNSAGTRYSAPANLYVRVRRVAPRFSIPP----SSQE--VMPGGSVNLTCVAVGAPMP 261
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W E ++ + + G N+ L ++NV + S +Y CVA +S G A+VT
Sbjct: 262 YVKWMMGAEELTKEDEMPV---GRNV-LELSNV---VRSANYTCVAISSLGMIEATAQVT 314
Query: 923 I 923
+
Sbjct: 315 V 315
Score = 71.7 bits (168), Expect = 3e-11
Identities = 81/317 (25%), Positives = 130/317 (41%), Gaps = 36/317 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY-YDDDNVATL 568
P+F++ + G F CQ G P+P+ITW ++ + SQ F++ +DD + L
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVS-SQRFEVIEFDDGAGSVL 91
Query: 569 VIREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
I+ + D + C A N+ G E+ A LS E
Sbjct: 92 RIQPLRVQRDEAIYECTATNSLG------EINTSAKLSVLEEEQ---------------- 129
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ G P + P+ + V++ + C P+P+I+W FK V + I+
Sbjct: 130 LPPGFP-SIDMGPQLKVVEKARTATMLCAAGGNPDPEISW-FKDFLPVDPATSNGRIKQ- 186
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+ L+I + ++ +G Y VA N G S P L ++ P I P S V
Sbjct: 187 --LRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPP-SSQEV 243
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G SV L+ VG P P + W + + TK D +L+ V YT
Sbjct: 244 MPGGSVNLTCVAVGAPMPYVKWMMGAEEL----TKEDEMPVGRNVLELSNVVRSANYTCV 299
Query: 807 AENSEGIAETSAVITVE 823
A +S G+ E +A +TV+
Sbjct: 300 AISSLGMIEATAQVTVK 316
Score = 64.5 bits (150), Expect = 4e-09
Identities = 62/254 (24%), Positives = 103/254 (40%), Gaps = 18/254 (7%)
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPSKPEGPVIM-REISRESVTIEWKPPLDDGGLELTKYA 1702
T+ A T G + V + P P +M + + ++W PP + G EL Y
Sbjct: 787 TVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPG-ELLGYR 845
Query: 1703 IEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT 1762
++ D R D +D + + + L++ Y+FR+ A+N G E E E I+T
Sbjct: 846 LQYCRADEAR-PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE---IRT 901
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKVEIKQEGKKWKXXXXX 1819
D+PS + + + W P +E+NG II Y V + + +
Sbjct: 902 PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG--RIISYTVVFRDINSQQELQNIT 959
Query: 1820 XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQ--PRNFVVSES 1877
+ L +TTY ++ A G+ P + +I P Q +NF V+ +
Sbjct: 960 TDTRFTLTGLKPDTTYDIKVRAWTSKGSG-PLSP----SIQSRTMPVEQVFAKNFRVAAA 1014
Query: 1878 TSRSVTLKWTEPES 1891
SV L W P+S
Sbjct: 1015 MKTSVLLSWEVPDS 1028
Score = 43.2 bits (97), Expect = 0.010
Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 10/107 (9%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FS P +Q V G + L C V P P + W+ EE+ E +M +
Sbjct: 230 VAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTK--------EDEMPVG 281
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+VL+++NV + YT VA++ G + +K K P ++
Sbjct: 282 RNVLELSNV--VRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLV 326
>AB177857-1|BAD66835.1| 1918|Homo sapiens LAR protein.
Length = 1918
Score = 128 bits (308), Expect = 3e-28
Identities = 211/1007 (20%), Positives = 386/1007 (38%), Gaps = 85/1007 (8%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTID-GKKQKLK 1164
P I ++Q G A+F + T + + W K G ++ + D G L+
Sbjct: 53 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLR 112
Query: 1165 IYDCDLD-DAGEYSCEVGNS----KCTAILTVEE--------PSINFTLRLPEFILVPAN 1211
I + D Y C NS +A L+V E PSI+ +L ++ A
Sbjct: 113 IQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLK--VVEKAR 170
Query: 1212 TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
T L + +++W+K ++ I ++ L I E DQ +Y CV
Sbjct: 171 TATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVAT 230
Query: 1272 DAKST-----TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
++ T L V V P+ + G V L P P +W++ ++
Sbjct: 231 NSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAE 290
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
+ K + S ++ T I L G + VT+ P PP
Sbjct: 291 ELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL------GMIEATAQVTVKALPKPPID 344
Query: 1387 PNILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTT-EWISVKNITKTQTSIQNLK 1444
+ E ++S+ + WD +GNS + YY ++Y+ T + V + T+ SI L
Sbjct: 345 LVVTETTATSVTLTWD----SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLS 400
Query: 1445 TNSSYRFRAYAVNEVDISDASE-----TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDI 1499
S Y FR AVN + SE T E ++Q+ + + EP E+
Sbjct: 401 PFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEP 460
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHG 1557
G V +V + D ++ A + Y + +AF G
Sbjct: 461 N-----GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVG 515
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE-VIWYKNGN-KLEN 1615
+ S + ++ + + D Q D + + + +PP E +I Y+ E+
Sbjct: 516 DGPPSPTIQVKTQQGVPAQPADF-QAEVESDTRIQLSWL--LPPQERIIMYELVYWAAED 572
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP--- 1672
+ + + T + TS +++LK ++ + A + G T++ S P P
Sbjct: 573 EDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQK 632
Query: 1673 VIMREISRESVTIEW-KPPLDDGGLELTKYAIEKHEPD-NNRWIKVAD-VDRDVETYCIQ 1729
V+ + +V + W PP D +T+Y++ D +R V D + R+ ++ +
Sbjct: 633 VMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLV 692
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW- 1788
L + EY V A VG ES P++++T DVPS +++ +V++ W
Sbjct: 693 GLEKWTEYRVWVRAHTDVG--PGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWK 750
Query: 1789 --FPSEKNGGSPIIDYKVEI--KQEGKKWKXXXXXXXXXARIQKLSIN-----TTYQFRI 1839
PS+++G I Y+V + G+ A Q+ +I+ TTY +
Sbjct: 751 LPVPSKQHG--QIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTV 808
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A G S KI + T P +P ++S + + L+W P+ G +
Sbjct: 809 AAYTTKGDGA--RSKPKI-VTTTGAVPGRP-TMMISTTAMNTALLQWHPPKELPGE-LLG 863
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRL 1959
Y +++ ++ + G + + + IFR++A+N G+ E + +
Sbjct: 864 YRLQYCRA-DEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE---I 919
Query: 1960 EKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW-DGGAPLLGYNIAIRDVTKTMWMEVGK 2018
+PS L + + ++ +W P + ++ Y + RD+ E+
Sbjct: 920 RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ--QELQN 977
Query: 2019 VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGE 2065
+ +T +F + L + TY I++ A G S PL + +P E
Sbjct: 978 ITTDT-RFTLTGLKPDTTYDIKVRAWTSKG-SGPLSPSIQSRTMPVE 1022
Score = 73.3 bits (172), Expect = 9e-12
Identities = 80/301 (26%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F K P+ Q G C+ P+P I W+ KG++ V + V IE D S
Sbjct: 53 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKK-VSSQRFEV-IEFD-DGAGS 109
Query: 694 VLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQG 749
VL+I ++ + E Y A N GE + L + E+ P P + + +V +
Sbjct: 110 VLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKA 169
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYTL 805
+ + GNP P I+W K+ PV P S+G + ++ + D+G Y
Sbjct: 170 RTATMLCAAGGNPDPEISWFKDFLPVD--PATSNGRIKQLRSGALQIESSEESDQGKYEC 227
Query: 806 KAENSEGI---AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
A NS G A + + V + PP QE V G++ L P+P
Sbjct: 228 VATNSAGTRYSAPANLYVRVRRVAPRFSIPP----SSQE--VMPGGSVNLTCVAVGAPMP 281
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W E ++ + + G N+ L ++NV + S +Y CVA +S G A+VT
Sbjct: 282 YVKWMMGAEELTKEDEMPV---GRNV-LELSNV---VRSANYTCVAISSLGMIEATAQVT 334
Query: 923 I 923
+
Sbjct: 335 V 335
Score = 71.7 bits (168), Expect = 3e-11
Identities = 81/317 (25%), Positives = 130/317 (41%), Gaps = 36/317 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY-YDDDNVATL 568
P+F++ + G F CQ G P+P+ITW ++ + SQ F++ +DD + L
Sbjct: 53 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVS-SQRFEVIEFDDGAGSVL 111
Query: 569 VIREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
I+ + D + C A N+ G E+ A LS E
Sbjct: 112 RIQPLRVQRDEAIYECTATNSLG------EINTSAKLSVLEEEQ---------------- 149
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ G P + P+ + V++ + C P+P+I+W FK V + I+
Sbjct: 150 LPPGFP-SIDMGPQLKVVEKARTATMLCAAGGNPDPEISW-FKDFLPVDPATSNGRIKQ- 206
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+ L+I + ++ +G Y VA N G S P L ++ P I P S V
Sbjct: 207 --LRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPP-SSQEV 263
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G SV L+ VG P P + W + + TK D +L+ V YT
Sbjct: 264 MPGGSVNLTCVAVGAPMPYVKWMMGAEEL----TKEDEMPVGRNVLELSNVVRSANYTCV 319
Query: 807 AENSEGIAETSAVITVE 823
A +S G+ E +A +TV+
Sbjct: 320 AISSLGMIEATAQVTVK 336
Score = 64.5 bits (150), Expect = 4e-09
Identities = 62/254 (24%), Positives = 103/254 (40%), Gaps = 18/254 (7%)
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPSKPEGPVIM-REISRESVTIEWKPPLDDGGLELTKYA 1702
T+ A T G + V + P P +M + + ++W PP + G EL Y
Sbjct: 807 TVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPG-ELLGYR 865
Query: 1703 IEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT 1762
++ D R D +D + + + L++ Y+FR+ A+N G E E E I+T
Sbjct: 866 LQYCRADEAR-PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE---IRT 921
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKVEIKQEGKKWKXXXXX 1819
D+PS + + + W P +E+NG II Y V + + +
Sbjct: 922 PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG--RIISYTVVFRDINSQQELQNIT 979
Query: 1820 XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQ--PRNFVVSES 1877
+ L +TTY ++ A G+ P + +I P Q +NF V+ +
Sbjct: 980 TDTRFTLTGLKPDTTYDIKVRAWTSKGSG-PLSP----SIQSRTMPVEQVFAKNFRVAAA 1034
Query: 1878 TSRSVTLKWTEPES 1891
SV L W P+S
Sbjct: 1035 MKTSVLLSWEVPDS 1048
Score = 43.2 bits (97), Expect = 0.010
Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 10/107 (9%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FS P +Q V G + L C V P P + W+ EE+ E +M +
Sbjct: 250 VAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTK--------EDEMPVG 301
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+VL+++NV + YT VA++ G + +K K P ++
Sbjct: 302 RNVLELSNV--VRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLV 346
>BC106713-1|AAI06714.1| 1505|Homo sapiens PTPRD protein protein.
Length = 1505
Score = 127 bits (307), Expect = 4e-28
Identities = 137/570 (24%), Positives = 231/570 (40%), Gaps = 50/570 (8%)
Query: 1440 IQNLKT-NSSYRFRAYAVNEV-DISDASETTEYYKVIKETKIQS--PTVEKPLKNITTEP 1495
IQ L+T + A N V +IS ++ T V++E +I PT++ + E
Sbjct: 84 IQPLRTPRDEAIYECVASNNVGEISVSTRLT----VLREDQIPRGFPTIDMGPQLKVVER 139
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTA-------KATYENRXXXXXXXXXXXXXXXY 1548
+ C G P P++TW++D + T+ + E+ Y
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGALQIEQSEESDQGKY 199
Query: 1549 KCIAFNDHG---EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
+C+A N G + V +++ P S + G +T V G P P V
Sbjct: 200 ECVATNSAGTRYSAPANLYVRVRRVPP-RFSIPPTNHEIMPGGSVNITCVAVGSPMPYVK 258
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W L + + I +V+ + ++++S + YT A +T G + V
Sbjct: 259 WMLGAEDLTPEDDMPIGR----NVLELNDVRQS--ANYTCVAMSTLGVIEAIAQITVKAL 312
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
P KP G ++ E + S+T+ W D G E Y I +H+P N+ + ++D T
Sbjct: 313 P-KPPGTPVVTESTATSITLTW----DSGNPEPVSYYIIQHKPKNSEEL-YKEIDGVATT 366
Query: 1726 -YCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
Y + L+ +Y FRV+A N +G SEP++ +T+ PS + + ++
Sbjct: 367 RYSVAGLSPYSDYEFRVVAVNNIG--RGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTI 424
Query: 1785 YITWF-PSEKNGGSP--IIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ W P E NG + Y ++ Q W I L TY ++ A
Sbjct: 425 LVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLA 484
Query: 1842 RNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYI 1901
IG P +SD ++ I +T P QP NF + S+ L WT P S+ I NY
Sbjct: 485 FTSIGDG-PLSSDIQV-ITQTGVP-GQPLNFKAEPESETSILLSWTPPRSD---TIANYE 538
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
+ +K + +I G+ + ++ +K FR++A + G+ T S R
Sbjct: 539 LVYKDGEHGEEQRITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISAR--- 593
Query: 1962 HATVPSPPTAPLEIRMVGSNIVMTSWGTPE 1991
T+ S ++ V V+ SW PE
Sbjct: 594 --TMQSMFAKNFHVKAVMKTSVLLSWEIPE 621
Score = 78.2 bits (184), Expect = 3e-13
Identities = 115/498 (23%), Positives = 198/498 (39%), Gaps = 40/498 (8%)
Query: 1598 GIPPPEVIWYKNGNKLENDKEYNITTKEKT-SVIRIKELKRSHSSK-YTIEASNTAG--T 1653
G P P+++W K G K+ N + I + + SV+RI+ L+ Y ASN G +
Sbjct: 49 GDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEIS 108
Query: 1654 SSVEVTLKVYDK-----PSKPEGPVI-MREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
S +T+ D+ P+ GP + + E +R + + D + K +
Sbjct: 109 VSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDT 168
Query: 1708 PDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP 1767
+NN IK + + I++ E+ + + +A N G + + + ++ P
Sbjct: 169 SNNNGRIKQLRSE-SIGALQIEQSEESDQGKYECVATNSAGTRYSAPAN-LYVRVRRVPP 226
Query: 1768 SXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQ 1827
+ SV IT GSP+ K + E +
Sbjct: 227 RFSIPPTNHEIMPGGSVNITCVAV----GSPMPYVKWMLGAEDLTPEDDMPIGRNV---- 278
Query: 1828 KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWT 1887
L +N Q Y + T + +IT+ PP P VV+EST+ S+TL W
Sbjct: 279 -LELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTP---VVTESTATSITLTW- 333
Query: 1888 EPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
+S P++ YII+ K + K + G + + + + + FR+ A N +G
Sbjct: 334 --DSGNPEPVSYYIIQHKPKNSEELYKEID-GVATTRYSVAGLSPYSDYEFRVVAVNNIG 390
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIR 2006
P+E + + A PS ++ RM+ S ++ W PE G + GY +
Sbjct: 391 RGPPSEPVLTQTSEQA--PSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTM 447
Query: 2007 DVTKTM--WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV--- 2061
D T+ + WM+ D I +L TY +++ A IG PL SD
Sbjct: 448 DPTQHVNNWMKHNVADSQIT--TIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQVITQTG 504
Query: 2062 IPGEGSHADEEPGEQTEV 2079
+PG+ + EP +T +
Sbjct: 505 VPGQPLNFKAEPESETSI 522
Score = 76.6 bits (180), Expect = 9e-13
Identities = 92/407 (22%), Positives = 160/407 (39%), Gaps = 40/407 (9%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID- 1157
T E PP +Q G A+F + T GD + W K G ++ + D
Sbjct: 18 TDAETPPRFTRTPVDQTGVSGGVASFICQAT-GDPRPKIVWNKKGKKVSNQRFEVIEFDD 76
Query: 1158 GKKQKLKIYDCDLD-DAGEYSCEVGN-----SKCTAILTVEEPSI--NF-TLRL-PEFIL 1207
G L+I D Y C N S T + + E I F T+ + P+ +
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 1208 VP-ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT---LIIRKCTEDDQ 1263
V T L + ++TW+K ++ + I ++ + L I + E DQ
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGALQIEQSEESDQ 196
Query: 1264 CEYTCVLLDAKST-----TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPN 1318
+Y CV ++ T L V V PP+ + I G V + P P
Sbjct: 197 GKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPY 256
Query: 1319 DEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL 1378
+W++ ++ + P D ++ + + Y + G + +T+
Sbjct: 257 VKWMLGAEDLT------PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVK 310
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTE-WISVKNITKT 1436
P PPG P + E ++SI + WD +GN + YY+++++ ++ E + + + T
Sbjct: 311 ALPKPPGTPVVTESTATSITLTWD----SGNPEPVSYYIIQHKPKNSEELYKEIDGVATT 366
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT 1483
+ S+ L S Y FR AVN + SE V+ +T Q+P+
Sbjct: 367 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSE-----PVLTQTSEQAPS 408
Score = 76.2 bits (179), Expect = 1e-12
Identities = 76/302 (25%), Positives = 120/302 (39%), Gaps = 31/302 (10%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV-FPEDAGTFT 582
G F CQ G PRP+I W ++ + + + +DD + + L I+ + P D +
Sbjct: 38 GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYE 97
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N G S +T L V I G PT P+
Sbjct: 98 CVASNNVGEISVSTRLTV----------------------LREDQIPRGF-PTIDMGPQL 134
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKK 702
+ V+ + C P+P+I W FK V N + I+ L+I ++
Sbjct: 135 KVVERTRTATMLCAASGNPDPEITW-FKDFLPVDTSNNNGRIKQLRSESIGALQIEQSEE 193
Query: 703 FQEGTYTVVAVNREG-EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+G Y VA N G S P L ++ + PP+ P + + G SV ++ VG+
Sbjct: 194 SDQGKYECVATNSAGTRYSAPANLYVRV-RRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 252
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
P P + W + + T D +L+ V+ YT A ++ G+ E A IT
Sbjct: 253 PMPYVKWMLGAEDL----TPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQIT 308
Query: 822 VE 823
V+
Sbjct: 309 VK 310
Score = 67.7 bits (158), Expect = 4e-10
Identities = 78/304 (25%), Positives = 126/304 (41%), Gaps = 30/304 (9%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F++ P Q G C+ P P I W KG++ V ++ V IE D
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEV-IEFD-DGSG 79
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
SVL+I ++ E Y VA N GE S+ L + ++ P P + + +V +
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 749 GESVILSAQVVGNPRPTITWCK---------NNKPVKALPTKSDGDTHSITILKPKKVKD 799
+ + GNP P ITW K NN +K L ++S G ++ + D
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGALQ----IEQSEESD 195
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRN 859
+G Y A NS G SA + PP F + G++ + +
Sbjct: 196 QGKYECVATNSAG-TRYSAPANLY--VRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 252
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P+P + W E ++P + + G N+ L + +V S +Y CVA ++ G A
Sbjct: 253 PMPYVKWMLGAEDLTPEDDMP---IGRNV-LELNDVR---QSANYTCVAMSTLGVIEAIA 305
Query: 920 RVTI 923
++T+
Sbjct: 306 QITV 309
Score = 48.8 bits (111), Expect = 2e-04
Identities = 73/357 (20%), Positives = 126/357 (35%), Gaps = 27/357 (7%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADI---LEGIPPTFSKKPKAQYVDEGSDILLEC 655
I ++ SD G V A++ + +PP FS P + G + + C
Sbjct: 188 IEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITC 247
Query: 656 RLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNR 715
V P P + W+ E++ P E DM + +VL++ +V+ Q YT VA++
Sbjct: 248 VAVGSPMPYVKWMLGAEDLTP--------EDDMPIGRNVLELNDVR--QSANYTCVAMST 297
Query: 716 EGEASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNK 773
G + +K K P P V E + I +S GNP P + +K
Sbjct: 298 LGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS--------GNPEPVSYYIIQHK 349
Query: 774 PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPP 833
P + + D + T + Y + I V T E A P
Sbjct: 350 PKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA--P 407
Query: 834 LFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVIT 893
R + + TI + + P I YR + P++ + + IT
Sbjct: 408 SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 467
Query: 894 NVDSEIDSGDY--KCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVIL 948
+ + + Y K +A S G + + + + + L E E +++L
Sbjct: 468 TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL 524
>BC013867-1|AAH13867.2| 510|Homo sapiens PALLD protein protein.
Length = 510
Score = 127 bits (306), Expect = 5e-28
Identities = 102/367 (27%), Positives = 162/367 (44%), Gaps = 23/367 (6%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
Q L+ E Y + + ++E D++ + P E MAP F KL+ +G V F C
Sbjct: 93 QRLISEIEY-RLERSPVDESGDEVQYGDVPV--ENGMAPFFEMKLKHYKIFEGMPVTFTC 149
Query: 532 QVEGYPRPQITWFRQTAIIKPSQD-FQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
+V G P+P+I WF+ I P D + + D D +L +D G +T +A N G
Sbjct: 150 RVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQG 209
Query: 591 FASSTTELIVEA-------PLSDHGSEMTVXXXXXXXXXXXXADILEG--IPPTFSKKPK 641
S T L+V+A P S G + ++ P F + P
Sbjct: 210 RISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPG 269
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI-ESDMHMYCSVLKITNV 700
V EG ++C++ +P PD++W G+ + PD + + E+ +H L I V
Sbjct: 270 DLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHS----LIIEPV 325
Query: 701 KKFQEGTYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGESVILSAQVV 759
G YT +A NR G+ S + L + E +PP IE L++ V G V L +V+
Sbjct: 326 TSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVL 385
Query: 760 GNPRPTITWCKNNKPV----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
G P P I W K N+ + + D + +++ +D G YT+ A+N GI
Sbjct: 386 GVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVS 445
Query: 816 TSAVITV 822
+A + V
Sbjct: 446 CTARLDV 452
Score = 89.8 bits (213), Expect = 9e-17
Identities = 87/333 (26%), Positives = 143/333 (42%), Gaps = 45/333 (13%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ P F K K + EG + CR+ P+P I W G++I P + I+ D+
Sbjct: 125 GMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSD-HYTIQRDLDG 183
Query: 691 YCSVLKITNVKKFQEGTYT-----------------VVAVNREGEASL-----PIVLKIK 728
CS L T +G YT V AVN+ G + P V + +
Sbjct: 184 TCS-LHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPR 242
Query: 729 T------GEKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
+ E EP P ++ + V++G+ + +V G P P ++W + KPV
Sbjct: 243 SRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPV 302
Query: 776 KALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ + HS+ I++P +D G+YT A N G S + V +E +
Sbjct: 303 RPDSAHKMLVRENGVHSL-IIEPVTSRDAGIYTCIATNRAGQNSFSLELVVA--AKEAHK 359
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS-ETITQNFDGENIEL 890
PP+FI + Q V + ++L RV P P I W + NE ++ S + ++ + D
Sbjct: 360 PPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYIC 419
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
++ ++ D+G Y A N AG S AR+ +
Sbjct: 420 LLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV 452
Score = 85.8 bits (203), Expect = 2e-15
Identities = 67/244 (27%), Positives = 103/244 (42%), Gaps = 27/244 (11%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E +E+ P F++ +G + +C+V G P P ++W ++P +M
Sbjct: 251 ENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKM 310
Query: 559 YYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXX 618
++ V +L+I V DAG +TC+A N AG S + EL V A H
Sbjct: 311 LVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLEL-VVAAKEAHK---------- 359
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE 678
PP F +K + V +G + LECR++ +P P I W + E +
Sbjct: 360 --------------PPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHST 405
Query: 679 NISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+ V++ D H Y +L I K G YTV A N G S L + T + Q
Sbjct: 406 D-RVSMHQDNHGYICLL-IQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQSQST 463
Query: 739 EPLK 742
+P K
Sbjct: 464 KPKK 467
Score = 52.8 bits (121), Expect = 1e-05
Identities = 35/153 (22%), Positives = 69/153 (45%), Gaps = 6/153 (3%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
EP +E P F+ ++TV+E ++ +V+ P P ++W + + + P
Sbjct: 253 EPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLV 312
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV----TFVKHLQKSYE 939
+ +I + D+G Y C+A+N AG++S + + ++ F++ LQ +
Sbjct: 313 RENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNT-G 371
Query: 940 TEEGKTVILECQTSHTVSTKWYHNKKEISGMDH 972
+G V LEC+ + + KKE + H
Sbjct: 372 VADGYPVRLECRVLGVPPPQIFW-KKENESLTH 403
Score = 49.6 bits (113), Expect = 1e-04
Identities = 47/187 (25%), Positives = 74/187 (39%), Gaps = 16/187 (8%)
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXX-XXXXX 1544
++T + + + C G+P P ++W DGK ++ A EN
Sbjct: 270 DLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRD 329
Query: 1545 XXXYKCIAFNDHGEVETS--CVVGIQQ--KPVITISNEDIKQKHKVGDEWLV--TAVIEG 1598
Y CIA N G+ S VV ++ KP + I Q V D + V + G
Sbjct: 330 AGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEK---LQNTGVADGYPVRLECRVLG 386
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVI--RIKELKRSHSSKYTIEASNTAGTSSV 1656
+PPP++ W K L + + ++ I I+ + + YT+ A N AG S
Sbjct: 387 VPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSC 446
Query: 1657 EVTLKVY 1663
L VY
Sbjct: 447 TARLDVY 453
Score = 47.6 bits (108), Expect = 5e-04
Identities = 48/191 (25%), Positives = 78/191 (40%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D V+E + ++ +++ T D+ W+ DG+ ++P + + L
Sbjct: 262 PHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLI 321
Query: 1076 IRNTSVHDEGEYSCILRD----ESCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y+CI + S + E+ V PP I +LQN V G E
Sbjct: 322 IEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLE 381
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQ-KLKIYDCDLDDAGEYSC----EV 1180
L + W K+ + S + + + D L I +DAG Y+ E
Sbjct: 382 CRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEA 441
Query: 1181 GNSKCTAILTV 1191
G CTA L V
Sbjct: 442 GIVSCTARLDV 452
Score = 46.4 bits (105), Expect = 0.001
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 7/100 (7%)
Query: 828 ENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE---TITQNFD 884
EN P F + + + E + RV NP P I W+++ + ISP TI ++ D
Sbjct: 123 ENGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLD 182
Query: 885 GE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
G ++ + +D D G+Y +A+N G+ S R+ +
Sbjct: 183 GTCSLHTTASTLD---DDGNYTIMAANPQGRISCTGRLMV 219
Score = 39.9 bits (89), Expect = 0.098
Identities = 19/76 (25%), Positives = 35/76 (46%), Gaps = 1/76 (1%)
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
Y + + ++ + +Y V E + +P E LK+ + TC G P+PK+
Sbjct: 101 YRLERSPVDESGDEVQYGDVPVENGM-APFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKI 159
Query: 1514 TWYRDGKKLKTAKATY 1529
W++DGK++ Y
Sbjct: 160 YWFKDGKQISPKSDHY 175
>AF464873-1|AAL69964.1| 1106|Homo sapiens myoneurin protein.
Length = 1106
Score = 127 bits (306), Expect = 5e-28
Identities = 102/367 (27%), Positives = 162/367 (44%), Gaps = 23/367 (6%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
Q L+ E Y + + ++E D++ + P E MAP F KL+ +G V F C
Sbjct: 742 QRLISEIEY-RLERSPVDESGDEVQYGDVPV--ENGMAPFFEMKLKHYKIFEGMPVTFTC 798
Query: 532 QVEGYPRPQITWFRQTAIIKPSQD-FQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
+V G P+P+I WF+ I P D + + D D +L +D G +T +A N G
Sbjct: 799 RVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQG 858
Query: 591 FASSTTELIVEA-------PLSDHGSEMTVXXXXXXXXXXXXADILEG--IPPTFSKKPK 641
S T L+V+A P S G + ++ P F + P
Sbjct: 859 RISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPG 918
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI-ESDMHMYCSVLKITNV 700
V EG ++C++ +P PD++W G+ + PD + + E+ +H L I V
Sbjct: 919 DLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHS----LIIEPV 974
Query: 701 KKFQEGTYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGESVILSAQVV 759
G YT +A NR G+ S + L + E +PP IE L++ V G V L +V+
Sbjct: 975 TSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVL 1034
Query: 760 GNPRPTITWCKNNKPV----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
G P P I W K N+ + + D + +++ +D G YT+ A+N GI
Sbjct: 1035 GVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVS 1094
Query: 816 TSAVITV 822
+A + V
Sbjct: 1095 CTARLDV 1101
Score = 90.6 bits (215), Expect = 5e-17
Identities = 87/337 (25%), Positives = 145/337 (43%), Gaps = 45/337 (13%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ P F K K + EG + CR+ P+P I W G++I P + I+ D+
Sbjct: 774 GMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSD-HYTIQRDLDG 832
Query: 691 YCSVLKITNVKKFQEGTYT-----------------VVAVNREGEASL-----PIVLKIK 728
CS L T +G YT V AVN+ G + P V + +
Sbjct: 833 TCS-LHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPR 891
Query: 729 T------GEKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
+ E EP P ++ + V++G+ + +V G P P ++W + KPV
Sbjct: 892 SRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPV 951
Query: 776 KALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ + HS+ I++P +D G+YT A N G S + V +E +
Sbjct: 952 RPDSAHKMLVRENGVHSL-IIEPVTSRDAGIYTCIATNRAGQNSFSLELVVA--AKEAHK 1008
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS-ETITQNFDGENIEL 890
PP+FI + Q V + ++L RV P P I W + NE ++ S + ++ + D
Sbjct: 1009 PPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYIC 1068
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
++ ++ D+G Y A N AG S AR+ + + +
Sbjct: 1069 LLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYISR 1105
Score = 83.0 bits (196), Expect = 1e-14
Identities = 42/107 (39%), Positives = 64/107 (59%), Gaps = 7/107 (6%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY-------DD 562
P+F ++L+ +G V EC+V G P Q+ WFRQ + I+ S DF++ +
Sbjct: 441 PVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEP 500
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGS 609
+ + TLVI E FPEDAG FTC A+N G A+ST +L+V + +++ S
Sbjct: 501 EEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTENCS 547
Score = 81.8 bits (193), Expect = 2e-14
Identities = 37/103 (35%), Positives = 63/103 (61%), Gaps = 1/103 (0%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP F++KLR + +GS V EC+V G P P++ WF + + + D Q++ + ++ TL
Sbjct: 270 APRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTL 329
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVE-APLSDHGSE 610
+I E F +D G +TC+A N +G +++ E+ +E A +D SE
Sbjct: 330 IIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDSDSE 372
Score = 53.2 bits (122), Expect = 1e-05
Identities = 39/138 (28%), Positives = 63/138 (45%), Gaps = 8/138 (5%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPT----KSDGDTHSIT 790
P+ I+ L+S V +G V L +V GNP P + W K + P GD H++
Sbjct: 271 PRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTLI 330
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVE--EPTEENAEPPLFINRFQEITVKEKG 848
I + + D G YT A N G TSA + +E T+ ++E F +R + +K
Sbjct: 331 IAEAFE-DDTGRYTCLATNPSGSDTTSAEVFIEGASSTDSDSESLAFKSRAGAMPQAQKK 389
Query: 849 TIKLVARV-TRNPVPSIT 865
T + + + +P +T
Sbjct: 390 TTSVSLTIGSSSPKTGVT 407
Score = 53.2 bits (122), Expect = 1e-05
Identities = 27/92 (29%), Positives = 46/92 (50%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVI 892
P FI + + V E + L RVT NP P + W+ + + + I + +G ++ +I
Sbjct: 271 PRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTLI 330
Query: 893 TNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
E D+G Y C+A+N +G + A V I+
Sbjct: 331 IAEAFEDDTGRYTCLATNPSGSDTTSAEVFIE 362
Score = 52.8 bits (121), Expect = 1e-05
Identities = 35/153 (22%), Positives = 69/153 (45%), Gaps = 6/153 (3%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
EP +E P F+ ++TV+E ++ +V+ P P ++W + + + P
Sbjct: 902 EPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLV 961
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV----TFVKHLQKSYE 939
+ +I + D+G Y C+A+N AG++S + + ++ F++ LQ +
Sbjct: 962 RENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNT-G 1020
Query: 940 TEEGKTVILECQTSHTVSTKWYHNKKEISGMDH 972
+G V LEC+ + + KKE + H
Sbjct: 1021 VADGYPVRLECRVLGVPPPQIFW-KKENESLTH 1052
Score = 50.4 bits (115), Expect = 7e-05
Identities = 29/85 (34%), Positives = 43/85 (50%), Gaps = 5/85 (5%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYC 692
P F +K ++Q V EGS + LECR+ P P + W +G+E+ +I + E D+H
Sbjct: 271 PRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLH--- 327
Query: 693 SVLKITNVKKFQEGTYTVVAVNREG 717
L I + G YT +A N G
Sbjct: 328 -TLIIAEAFEDDTGRYTCLATNPSG 351
Score = 49.6 bits (113), Expect = 1e-04
Identities = 47/187 (25%), Positives = 74/187 (39%), Gaps = 16/187 (8%)
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXX-XXXXX 1544
++T + + + C G+P P ++W DGK ++ A EN
Sbjct: 919 DLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRD 978
Query: 1545 XXXYKCIAFNDHGEVETS--CVVGIQQ--KPVITISNEDIKQKHKVGDEWLV--TAVIEG 1598
Y CIA N G+ S VV ++ KP + I Q V D + V + G
Sbjct: 979 AGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEK---LQNTGVADGYPVRLECRVLG 1035
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVI--RIKELKRSHSSKYTIEASNTAGTSSV 1656
+PPP++ W K L + + ++ I I+ + + YT+ A N AG S
Sbjct: 1036 VPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSC 1095
Query: 1657 EVTLKVY 1663
L VY
Sbjct: 1096 TARLDVY 1102
Score = 47.6 bits (108), Expect = 5e-04
Identities = 48/191 (25%), Positives = 78/191 (40%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D V+E + ++ +++ T D+ W+ DG+ ++P + + L
Sbjct: 911 PHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLI 970
Query: 1076 IRNTSVHDEGEYSCILRD----ESCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y+CI + S + E+ V PP I +LQN V G E
Sbjct: 971 IEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLE 1030
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQ-KLKIYDCDLDDAGEYSC----EV 1180
L + W K+ + S + + + D L I +DAG Y+ E
Sbjct: 1031 CRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEA 1090
Query: 1181 GNSKCTAILTV 1191
G CTA L V
Sbjct: 1091 GIVSCTARLDV 1101
Score = 46.4 bits (105), Expect = 0.001
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 7/100 (7%)
Query: 828 ENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE---TITQNFD 884
EN P F + + + E + RV NP P I W+++ + ISP TI ++ D
Sbjct: 772 ENGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLD 831
Query: 885 GE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
G ++ + +D D G+Y +A+N G+ S R+ +
Sbjct: 832 GTCSLHTTASTLD---DDGNYTIMAANPQGRISCTGRLMV 868
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 2/78 (2%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID-GKKQKLK 1164
P I +L++Q+V +G++ E +T VRWF +G E+ + IQ+ + G L
Sbjct: 271 PRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTLI 330
Query: 1165 IYDCDLDDAGEYSCEVGN 1182
I + DD G Y+C N
Sbjct: 331 IAEAFEDDTGRYTCLATN 348
Score = 39.9 bits (89), Expect = 0.098
Identities = 19/76 (25%), Positives = 35/76 (46%), Gaps = 1/76 (1%)
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
Y + + ++ + +Y V E + +P E LK+ + TC G P+PK+
Sbjct: 750 YRLERSPVDESGDEVQYGDVPVENGM-APFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKI 808
Query: 1514 TWYRDGKKLKTAKATY 1529
W++DGK++ Y
Sbjct: 809 YWFKDGKQISPKSDHY 824
Score = 39.5 bits (88), Expect = 0.13
Identities = 62/278 (22%), Positives = 101/278 (36%), Gaps = 30/278 (10%)
Query: 930 FVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXX 987
F++ L +S E EG V LEC+ + T +W+ KE+ +I EG
Sbjct: 273 FIQKL-RSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTLII 331
Query: 988 XXXXXD-VGVIKCIVKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G C+ + +T++ V E + K + A+ + + +
Sbjct: 332 AEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDSDSESLAFKSRAGAMPQAQKKTT 391
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
+ + PK I+ L + VH Y C R + T
Sbjct: 392 SVSLTIGSSS----PKTGV----TTAVIQPLSVPVQQVHSPTSYLC--RPDG----TTTA 437
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQK 1162
PP LQN V +G E + L V+WF+ GSEIQ S ++ +
Sbjct: 438 YFPPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRST 497
Query: 1163 LKIYD-CDL-------DDAGEYSCEVGNSKCTAILTVE 1192
+ + C L +DAG ++C N +A T +
Sbjct: 498 AEPEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQ 535
Score = 38.3 bits (85), Expect = 0.30
Identities = 26/106 (24%), Positives = 46/106 (43%), Gaps = 10/106 (9%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP--------TKSDGD 785
PP + L++ V +G+ V+L +V G P + W + ++ P +S +
Sbjct: 440 PPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAE 499
Query: 786 THSITILKPKKV--KDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
I L + +D G++T A N G A ++A + V EN
Sbjct: 500 PEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTEN 545
Score = 37.9 bits (84), Expect = 0.39
Identities = 29/105 (27%), Positives = 44/105 (41%), Gaps = 4/105 (3%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEI--VPDENISVAIESDMHM 690
PP F+K+ + V EG ++LECR+ P + W +G EI PD I
Sbjct: 440 PPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAE 499
Query: 691 YCSVLKITNVKKFQE--GTYTVVAVNREGEASLPIVLKIKTGEKE 733
+ + + F E G +T A N G A+ L + + E
Sbjct: 500 PEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTE 544
Score = 36.3 bits (80), Expect = 1.2
Identities = 29/100 (29%), Positives = 40/100 (40%), Gaps = 9/100 (9%)
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQNFDGENIE 889
PP+F Q V E + L RV P + W+R I SP I Q E
Sbjct: 440 PPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAE 499
Query: 890 ------LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
LVI E D+G + C A N G ++ A++ +
Sbjct: 500 PEEICTLVIAETFPE-DAGIFTCSARNDYGSATSTAQLVV 538
>AB023209-1|BAA76836.1| 772|Homo sapiens KIAA0992 protein protein.
Length = 772
Score = 127 bits (306), Expect = 5e-28
Identities = 102/367 (27%), Positives = 162/367 (44%), Gaps = 23/367 (6%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
Q L+ E Y + + ++E D++ + P E MAP F KL+ +G V F C
Sbjct: 355 QRLISEIEY-RLERSPVDESGDEVQYGDVPV--ENGMAPFFEMKLKHYKIFEGMPVTFTC 411
Query: 532 QVEGYPRPQITWFRQTAIIKPSQD-FQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
+V G P+P+I WF+ I P D + + D D +L +D G +T +A N G
Sbjct: 412 RVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQG 471
Query: 591 FASSTTELIVEA-------PLSDHGSEMTVXXXXXXXXXXXXADILEG--IPPTFSKKPK 641
S T L+V+A P S G + ++ P F + P
Sbjct: 472 RISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPG 531
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI-ESDMHMYCSVLKITNV 700
V EG ++C++ +P PD++W G+ + PD + + E+ +H L I V
Sbjct: 532 DLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHS----LIIEPV 587
Query: 701 KKFQEGTYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGESVILSAQVV 759
G YT +A NR G+ S + L + E +PP IE L++ V G V L +V+
Sbjct: 588 TSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVL 647
Query: 760 GNPRPTITWCKNNKPV----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
G P P I W K N+ + + D + +++ +D G YT+ A+N GI
Sbjct: 648 GVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVS 707
Query: 816 TSAVITV 822
+A + V
Sbjct: 708 CTARLDV 714
Score = 89.8 bits (213), Expect = 9e-17
Identities = 87/333 (26%), Positives = 143/333 (42%), Gaps = 45/333 (13%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ P F K K + EG + CR+ P+P I W G++I P + I+ D+
Sbjct: 387 GMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSD-HYTIQRDLDG 445
Query: 691 YCSVLKITNVKKFQEGTYT-----------------VVAVNREGEASL-----PIVLKIK 728
CS L T +G YT V AVN+ G + P V + +
Sbjct: 446 TCS-LHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPR 504
Query: 729 T------GEKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
+ E EP P ++ + V++G+ + +V G P P ++W + KPV
Sbjct: 505 SRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPV 564
Query: 776 KALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ + HS+ I++P +D G+YT A N G S + V +E +
Sbjct: 565 RPDSAHKMLVRENGVHSL-IIEPVTSRDAGIYTCIATNRAGQNSFSLELVVA--AKEAHK 621
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS-ETITQNFDGENIEL 890
PP+FI + Q V + ++L RV P P I W + NE ++ S + ++ + D
Sbjct: 622 PPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYIC 681
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
++ ++ D+G Y A N AG S AR+ +
Sbjct: 682 LLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV 714
Score = 85.8 bits (203), Expect = 2e-15
Identities = 67/244 (27%), Positives = 103/244 (42%), Gaps = 27/244 (11%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E +E+ P F++ +G + +C+V G P P ++W ++P +M
Sbjct: 513 ENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKM 572
Query: 559 YYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXX 618
++ V +L+I V DAG +TC+A N AG S + EL V A H
Sbjct: 573 LVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLEL-VVAAKEAHK---------- 621
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE 678
PP F +K + V +G + LECR++ +P P I W + E +
Sbjct: 622 --------------PPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHST 667
Query: 679 NISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+ V++ D H Y +L I K G YTV A N G S L + T + Q
Sbjct: 668 D-RVSMHQDNHGYICLL-IQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQSQST 725
Query: 739 EPLK 742
+P K
Sbjct: 726 KPKK 729
Score = 52.8 bits (121), Expect = 1e-05
Identities = 35/153 (22%), Positives = 69/153 (45%), Gaps = 6/153 (3%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
EP +E P F+ ++TV+E ++ +V+ P P ++W + + + P
Sbjct: 515 EPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLV 574
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV----TFVKHLQKSYE 939
+ +I + D+G Y C+A+N AG++S + + ++ F++ LQ +
Sbjct: 575 RENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNT-G 633
Query: 940 TEEGKTVILECQTSHTVSTKWYHNKKEISGMDH 972
+G V LEC+ + + KKE + H
Sbjct: 634 VADGYPVRLECRVLGVPPPQIFW-KKENESLTH 665
Score = 49.6 bits (113), Expect = 1e-04
Identities = 47/187 (25%), Positives = 74/187 (39%), Gaps = 16/187 (8%)
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXX-XXXXX 1544
++T + + + C G+P P ++W DGK ++ A EN
Sbjct: 532 DLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRD 591
Query: 1545 XXXYKCIAFNDHGEVETS--CVVGIQQ--KPVITISNEDIKQKHKVGDEWLV--TAVIEG 1598
Y CIA N G+ S VV ++ KP + I Q V D + V + G
Sbjct: 592 AGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEK---LQNTGVADGYPVRLECRVLG 648
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVI--RIKELKRSHSSKYTIEASNTAGTSSV 1656
+PPP++ W K L + + ++ I I+ + + YT+ A N AG S
Sbjct: 649 VPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSC 708
Query: 1657 EVTLKVY 1663
L VY
Sbjct: 709 TARLDVY 715
Score = 47.6 bits (108), Expect = 5e-04
Identities = 48/191 (25%), Positives = 78/191 (40%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D V+E + ++ +++ T D+ W+ DG+ ++P + + L
Sbjct: 524 PHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLI 583
Query: 1076 IRNTSVHDEGEYSCILRD----ESCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y+CI + S + E+ V PP I +LQN V G E
Sbjct: 584 IEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLE 643
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQ-KLKIYDCDLDDAGEYSC----EV 1180
L + W K+ + S + + + D L I +DAG Y+ E
Sbjct: 644 CRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEA 703
Query: 1181 GNSKCTAILTV 1191
G CTA L V
Sbjct: 704 GIVSCTARLDV 714
Score = 46.4 bits (105), Expect = 0.001
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 7/100 (7%)
Query: 828 ENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE---TITQNFD 884
EN P F + + + E + RV NP P I W+++ + ISP TI ++ D
Sbjct: 385 ENGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLD 444
Query: 885 GE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
G ++ + +D D G+Y +A+N G+ S R+ +
Sbjct: 445 GTCSLHTTASTLD---DDGNYTIMAANPQGRISCTGRLMV 481
Score = 39.9 bits (89), Expect = 0.098
Identities = 19/76 (25%), Positives = 35/76 (46%), Gaps = 1/76 (1%)
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
Y + + ++ + +Y V E + +P E LK+ + TC G P+PK+
Sbjct: 363 YRLERSPVDESGDEVQYGDVPVENGM-APFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKI 421
Query: 1514 TWYRDGKKLKTAKATY 1529
W++DGK++ Y
Sbjct: 422 YWFKDGKQISPKSDHY 437
>AF304304-1|AAN32613.1| 2053|Homo sapiens Down syndrome cell adhesion
molecule like-protein 1a protein.
Length = 2053
Score = 126 bits (304), Expect = 9e-28
Identities = 313/1503 (20%), Positives = 549/1503 (36%), Gaps = 161/1503 (10%)
Query: 541 ITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDA-GTFTCVAKNAAGFASSTTELI 599
++W + T I P F + Y L I +V EDA T+ C+ K+ ++ T +
Sbjct: 159 VSWEKDTVSIIPEHRFFITYHGG----LYISDVQKEDALSTYRCITKHK--YSGETRQ-- 210
Query: 600 VEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVA 659
+G+ ++V D E IP T +Q V G + L C
Sbjct: 211 ------SNGARLSVT------------DPAESIP-TILDGFHSQEVWAGHTVELPCTASG 251
Query: 660 IPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEA 719
P P I WL G + D + I L I++++ GTY N G A
Sbjct: 252 YPIPAIRWLKDGRPLPADSRWTKRITG--------LTISDLRTEDSGTYICEVTNTFGSA 303
Query: 720 SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP 779
+L + +P V K + G +VILS + G+P TI W +N + V LP
Sbjct: 304 EATGILMVI----DPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELV--LP 357
Query: 780 TKS---DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFI 836
++ G ++ ++ + G Y A A+ A+I +E+ T P +
Sbjct: 358 DEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT------PRIV 411
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNF---DGENIELVI 892
+ F E V L+ P P++TW ++E I+ T + DG I +
Sbjct: 412 SSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISYMN 471
Query: 893 TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT 952
D G Y+C A N G + + AR I+V ++ + ++ G+ ++ C+
Sbjct: 472 VTGPQIRDGGVYRCTARNLVGSAEYQAR--INVRGPPSIRAM-RNITAVAGRDTLINCRV 528
Query: 953 --SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTML 1010
S KWY + + +HR+++ E D G C V Q ++
Sbjct: 529 IGYPYYSIKWYKDALLLPD-NHRQVVFE-NGTLKLTDVQKGMDEGEYLCSVLIQPQLSIS 586
Query: 1011 VVKETIPEFIRKLQDFEVKEKDVA-ILEVEINSETAD----VVWERDGEIIKPKKNKYDF 1065
+ +Q FE + +L + + D + W +DG++I +
Sbjct: 587 QSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVI-ISGSGVTI 645
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA---EVTVVELPPEIITRLQNQKVNKGN 1122
E + + L I + S+ G +CI + + T +V +PP + + NQ G
Sbjct: 646 ESKEFMSSLQISSVSLKHNGNDTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGK 705
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQ-----KLKIYDCDLDDAGEY 1176
+ V W + + + G+ Q L I +D G Y
Sbjct: 706 AGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYY 765
Query: 1177 SCEVGNSKCTAI-----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYK 1231
C+ N T I LTV+ P++ T I + + + + + W K
Sbjct: 766 LCQASNGVGTDISKSMFLTVKIPAM-ITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK 824
Query: 1232 KKSVIEDTE--KFTLIS----DVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-V 1284
+VI+ ++ + + D TL ++ D ++C +++ + +++ V
Sbjct: 825 GDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTV 884
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSI--DSKS 1342
+ PP E E R + + L Q F + I I K K +++
Sbjct: 885 QEPPD--PPELEIREVKARSMNLRWT-QRF--DGNSIITGFDIEYKNKSDSWDFKQSTRN 939
Query: 1343 ASLTIKKVENTD---AGIYKLRLE--NNCGHADVEMNVTI-LDKPSPPGKP---NILEID 1393
S TI + D A +Y +R+ N G ++ +TI ++ +P G P + +
Sbjct: 940 ISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVT 999
Query: 1394 SSSINICWDEP-ENTGNSTIIYYVVEYQEID--TTEWISVKNITKTQTS----IQNLKTN 1446
S SI + W P + N I Y + Y+E + S+ + T S + NLK
Sbjct: 1000 SQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKF 1059
Query: 1447 SSYRFRAYAVNEVDISDASE-----TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIEL 1501
+ Y A N +S T E +++ ++ + I+ L
Sbjct: 1060 AQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTL 1119
Query: 1502 TCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
+ G + Y DG+ + T R + +A+ G+
Sbjct: 1120 NGVLKGYRVIFWSLYVDGEWGEMQNIT-TTRERVELRGMEKFTNYSVQVLAYTQAGDGVR 1178
Query: 1562 SCVVGIQQKPVITISNEDIK----QKHKVGDEWLVTAVIEGIPPPEVIWYKN-GNKLEND 1616
S V+ IQ K + IK V WL G+ I+ + G+
Sbjct: 1179 SSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAP 1238
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA--GTSSVEVTLKVYDKPSKPEGPVI 1674
EY T + RI L R + A +A G SS +VT+ +P G
Sbjct: 1239 SEYE--TSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTI-------EPAGKAP 1289
Query: 1675 MREIS-RESVTIEW----KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE---TY 1726
+ IS +VT W + P + G K D+ + + D R + T
Sbjct: 1290 AKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSM-DGHRLIHTNGTL 1348
Query: 1727 CIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYI 1786
++ + + A N GF + I++ + VP S+ +
Sbjct: 1349 LLRAVKAEDSGYYTCTATNTGGF------DTIIVNLLVQVPPDQPRLTVSKT-SASSITL 1401
Query: 1787 TWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXA-RIQKLSINTTYQFRIYARNE 1844
TW P + NGGS I + ++ ++WK + ++ L T Y+ ++ A+N
Sbjct: 1402 TWIPGD-NGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNS 1460
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLK-WTEPESNGGSPITNYIIE 1903
+G+ + T G+ + F ST + L+ W +NGG PIT ++E
Sbjct: 1461 VGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGW----NNGGCPITAIVLE 1516
Query: 1904 FKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHA 1963
++ KG +W S E + ++E R+ A N+ G T + +
Sbjct: 1517 YRP-KG-TWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGS 1574
Query: 1964 TVP 1966
T+P
Sbjct: 1575 TIP 1577
Score = 115 bits (276), Expect = 2e-24
Identities = 215/1069 (20%), Positives = 404/1069 (37%), Gaps = 120/1069 (11%)
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE-GEYSCILRD-------ESCTA 1098
V WE+D I P+ + G LYI + D Y CI + +S A
Sbjct: 159 VSWEKDTVSIIPEHRFFITYHGG----LYISDVQKEDALSTYRCITKHKYSGETRQSNGA 214
Query: 1099 EVTVV---ELPPEIITRLQNQKVNKGNKATFEIELTKGD---ALVRWFKDGSEIQFSNHI 1152
++V E P I+ +Q+V G+ T E+ T +RW KDG + +
Sbjct: 215 RLSVTDPAESIPTILDGFHSQEVWAGH--TVELPCTASGYPIPAIRWLKDGRPLPADSRW 272
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRLPEFILV 1208
I G L I D +D+G Y CEV G+++ T IL V +P ++ TL P+ +
Sbjct: 273 TKRITG----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDP-LHVTLT-PKKLKT 326
Query: 1209 PANTDAYLTVEIPDET-LDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYT 1267
+ L+ + + WY+ ++ E + I + TL+I + Y
Sbjct: 327 GIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAIS-IRGLSNETLLITSAQKSHSGAYQ 385
Query: 1268 CVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNS 1325
C T + + + + P+IV E + G +L+ + P P W ++
Sbjct: 386 CFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 445
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENT-----DAGIYKLRLENNCGHADVEMNVTILDK 1380
+ I + + + + S TI + T D G+Y+ N G A+ + + +
Sbjct: 446 EPIVRDGSHRTNQYTMSDGTTISYMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGP 505
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE-YQEI----DTTEWISVKNITK 1435
PS NI + I N YY ++ Y++ D + +N T
Sbjct: 506 PSIRAMRNITAVAGRDTLI------NCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTL 559
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP 1495
T +Q Y ++ IS + ++ P + +P +
Sbjct: 560 KLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVA----------VKVPPLIQPFEFPPASI 609
Query: 1496 NEDIELTCIFGGVPQP-KVTWYRDGKKLKTAKA-TYENRXXXXXXXXXXXXXXXY---KC 1550
+ + + C+ P ++TW +DG+ + + T E++ C
Sbjct: 610 GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNDTC 669
Query: 1551 IAFNDHGEV--ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYK 1608
IA N V E +V + + V+ +N+D G ++ ++G PPP+V+W K
Sbjct: 670 IASNAAATVSRERQLIVRVPPRFVVQPNNQD----GIYGKAGVLNCSVDGYPPPKVMW-K 724
Query: 1609 NGNKLENDKEYN---ITTKEK---TSVIRIKELKRSHSSKYTIEASNTAGTS---SVEVT 1659
+ N ++Y+ +T + + S + I+ + Y +ASN GT S+ +T
Sbjct: 725 HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLT 784
Query: 1660 LKVYDK-PSKPEGPVIMREISRE-SVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA 1717
+K+ S P + ++ ++E + T + P+ + ++ D +R ++ A
Sbjct: 785 VKIPAMITSHPNTTIAIKGHAKELNCTARGERPI------IIRWEKGDTVIDPDRVMRYA 838
Query: 1718 DVDRD-----VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
+D V T ++ + F A N G L + ++ D P
Sbjct: 839 IATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQ--LTVQEPPDPPELEIR 896
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSI- 1831
+ S+ + W +G S I + +E K + W I + +I
Sbjct: 897 E-----VKARSMNLRW-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIV 950
Query: 1832 ----NTTYQFRIYARNEIGTSLPYTSDDKITIG-KTLTPPSQPRNFVVSESTSRSVTLKW 1886
+ Y R+Y+ N+IG S P ++TI + P P + + TS+S+ + W
Sbjct: 951 DLHPASVYSIRMYSFNKIGRSEP---SKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTW 1007
Query: 1887 TEPESN-GGSPITNYIIEFKT----VKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRIS 1941
P+ I Y I ++ G+ + G + ++N+K+ + +
Sbjct: 1008 KAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQ 1067
Query: 1942 AENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDG-GAPLLG 2000
A N G P+ S+ + VPS P + + S++ + SW P L G
Sbjct: 1068 AFNRAGTG-PSSSE-INATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKG 1125
Query: 2001 YNIAIRDV-TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
Y + + W E+ + + +R + + Y +++ A + G
Sbjct: 1126 YRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAG 1174
Score = 83.4 bits (197), Expect = 8e-15
Identities = 156/752 (20%), Positives = 270/752 (35%), Gaps = 55/752 (7%)
Query: 651 ILLECRLVAIPEPDIAW-LFKGEEIVPDENIS-VAIESDMHMYCSVLKITNVKKFQEGTY 708
+++ C P + W L G++I +I V + +Y N + Y
Sbjct: 43 VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFN-SFIHDNDY 101
Query: 709 TVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVRQGESVILSAQV--VGNPRPT 765
A N G+ P + ++K +EP V +E +SM +G + + +G +
Sbjct: 102 FCTAENAAGKIRSPNI-RVKAVFREPYTVRVEDQRSM---RGNVAVFKCLIPFLGQEYVS 157
Query: 766 I-TWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
+ +W K+ P G + + K + T + E A ++
Sbjct: 158 VVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 217
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
V +P E P ++ F V T++L + P+P+I W ++ + T+
Sbjct: 218 VTDPAESI---PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK 274
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-SHGARVTIDVEKVTFVKHLQKSYET 940
G L I+++ +E DSG Y C +N+ G + + G + ID VT K +T
Sbjct: 275 RITG----LTISDLRTE-DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTP---KKLKT 326
Query: 941 EEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIK 998
G TVIL C S + +WY N E+ D I+ G +
Sbjct: 327 GIGSTVILSCALTGSPEFTIRWYRNT-ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 385
Query: 999 CIV-KDQETS---TMLVVKETIPEFIRKLQDFEVKE-KDVAILEVEINSETADVVWERDG 1053
C + +T+ ++ +++ P + + V + +++ + V W D
Sbjct: 386 CFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 445
Query: 1054 EII----KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELP 1106
E I + N+Y I + + + D G Y C R+ +AE V P
Sbjct: 446 EPIVRDGSHRTNQYTMSDGTTISYMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGP 505
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P I ++N G + ++W+KD + NH Q+ + KL
Sbjct: 506 PSI-RAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLP-DNHRQVVFENGTLKLTD 563
Query: 1166 YDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL----TVEIP 1221
+D+ GEY C V +I ++ + F PA+ L V
Sbjct: 564 VQKGMDE-GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSG 622
Query: 1222 DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
D + +TW K VI T+ S +L I + TC+ +A +T +
Sbjct: 623 DMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNDTCIASNAAATVSRER 682
Query: 1282 E-VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEW-IVNSKIIKKCKHTKPSID 1339
+ +V PP+ V G L +P P W + H P
Sbjct: 683 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 742
Query: 1340 S----KSASLTIKKVENTDAGIYKLRLENNCG 1367
++SL I+ V D G Y + N G
Sbjct: 743 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVG 774
Score = 61.7 bits (143), Expect = 3e-08
Identities = 96/440 (21%), Positives = 167/440 (37%), Gaps = 36/440 (8%)
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI- 1678
NITT + +R E ++S + + A AG L + K P P ++ +
Sbjct: 1144 NITTTRERVELRGMEKFTNYSVQ--VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVP 1201
Query: 1679 -SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCE 1736
S SV + W PP G+ + KY I P + + + + Y I LN +
Sbjct: 1202 SSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1260
Query: 1737 YMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGG 1796
Y+ V A G + SE + I+ A P+ +V W +
Sbjct: 1261 YLLWVAAVTSAGRGNS--SEKVTIEPAGKAPAKIISFGG-------TVTTPWMKDVRLPC 1311
Query: 1797 SPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG----TSLPYT 1852
+ + D +K R+ + N T R + G T+
Sbjct: 1312 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRL--IHTNGTLLLRAVKAEDSGYYTCTATNTG 1369
Query: 1853 SDDKITIGKTL-TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS 1911
D I + + PP QPR VS++++ S+TL W P NGGS I +++++ +
Sbjct: 1370 GFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEE 1427
Query: 1912 WTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPS---P 1968
W K V + S ++++K +++A+N+VG S+ + + H PS
Sbjct: 1428 W-KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG--RISEIIEAKTHGREPSFSKD 1484
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNI 2028
I + + + W +GG P+ + R K W G ++ + +
Sbjct: 1485 QHLFTHINSTHARLNLQGWN----NGGCPITAIVLEYR--PKGTWAWQGLRANSSGEVFL 1538
Query: 2029 RDLSENHTYMIRIYARNEIG 2048
+L E Y +R+ A N G
Sbjct: 1539 TELREATWYELRMRACNSAG 1558
Score = 60.1 bits (139), Expect = 9e-08
Identities = 101/472 (21%), Positives = 175/472 (37%), Gaps = 54/472 (11%)
Query: 516 LRPKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
L PK T GSTV C + G P I W+R T ++ P + + + TL+I
Sbjct: 319 LTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE--TLLITSA 376
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
+G + C A A A + +E D I
Sbjct: 377 QKSHSGAYQCFATRKAQTAQDFAIIALE-------------------------DGTPRIV 411
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPD--ENISVAIESDMHMY 691
+FS+K V+ G L C P P + W E IV D + SD
Sbjct: 412 SSFSEK----VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSD-GTT 466
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
S + +T + G Y A N G A + + + PP I ++++ G
Sbjct: 467 ISYMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV----RGPPS-IRAMRNITAVAGRD 521
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+++ +V+G P +I W K+ + + + ++ + +K DEG Y
Sbjct: 522 TLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQP 581
Query: 812 GIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
++ + +V + V+ P P + F ++ + I V P+ ITW ++
Sbjct: 582 QLSISQSVHVAVKVP------PLIQPFEFPPASIGQLLYIPCVVSSGDMPI-RITWRKDG 634
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
++I +T L I++V + +G+ C+ASN+A S ++ + V
Sbjct: 635 QVIISGSGVTIESKEFMSSLQISSVSLK-HNGNDTCIASNAAATVSRERQLIVRVPPRFV 693
Query: 931 VKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGR 980
V+ + + GK +L C K W H K + + + GR
Sbjct: 694 VQ--PNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 743
Score = 47.2 bits (107), Expect = 6e-04
Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 5/108 (4%)
Query: 499 EKPTSEEQSMAPIFVEKLRPK-HTPDGSTVQFECQVEGYPRPQITWFRQT--AIIKPSQD 555
EK T E AP + TP V+ C G P P + W + + + I S D
Sbjct: 1278 EKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD 1337
Query: 556 FQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ TL++R V ED+G +TC A N GF + L+V+ P
Sbjct: 1338 GHRLIHTNG--TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1383
Score = 45.6 bits (103), Expect = 0.002
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 4/92 (4%)
Query: 1964 TVPSPPTAP-LEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
TV PP P LEIR V + + W T +DG + + G++I ++ + + + +++
Sbjct: 883 TVQEPPDPPELEIREVKARSMNLRW-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNIS 941
Query: 2023 TL--KFNIRDLSENHTYMIRIYARNEIGLSEP 2052
+ NI DL Y IR+Y+ N+IG SEP
Sbjct: 942 PTINQANIVDLHPASVYSIRMYSFNKIGRSEP 973
Score = 44.8 bits (101), Expect = 0.003
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 5/95 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P ++ + G TV+ C GYP P I W + + + + L
Sbjct: 226 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK-----RITGLT 280
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
I ++ ED+GT+ C N G A +T L+V PL
Sbjct: 281 ISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPL 315
Score = 36.7 bits (81), Expect = 0.91
Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 5/85 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV----ATLVIREVFPEDAG 579
G C V+GYP P++ W P Q + ++L+IR V ED G
Sbjct: 704 GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIG 763
Query: 580 TFTCVAKNAAGF-ASSTTELIVEAP 603
+ C A N G S + L V+ P
Sbjct: 764 YYLCQASNGVGTDISKSMFLTVKIP 788
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/100 (25%), Positives = 34/100 (34%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKP-SQDFQMYYDDDNVAT 567
P V K G C +G P P +TW I++ S Y D
Sbjct: 408 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 467
Query: 568 LVIREVFPE--DAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ P+ D G + C A+N G A + V P S
Sbjct: 468 SYMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 507
>BC117674-1|AAI17675.2| 1240|Homo sapiens NFASC protein protein.
Length = 1240
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 307
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 308 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 363
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 364 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 423
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 424 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 475
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 476 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 532
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 533 ARRGTTVQLECRVKHDPSLK 552
Score = 116 bits (279), Expect = 9e-25
Identities = 138/593 (23%), Positives = 233/593 (39%), Gaps = 42/593 (7%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXX---XXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 464 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLD-DGGLELTKYAIEKHEP--DNNRWIKVAD---- 1718
P +++R T++ + + D L+LT ++ EP NR K D
Sbjct: 522 TRIYRMPE--DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI 579
Query: 1719 ---VDRDVETY-CIQ--KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
+RD +Y C+ +L+++ + + + + L + P K D P
Sbjct: 580 FGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALP---KGRPDRPRDLEL 636
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXX-XXXXARIQK 1828
+ SV +TW P + N SPI DY V+ +++ + W + + +
Sbjct: 637 TD----LAERSVRLTWIPGDANN-SPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLR 691
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
LS YQFR+ A NE+G+S P ++ P S P + + ++ + WT
Sbjct: 692 LSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGA-PPESNPGDVKGEGTRKNNMEITWTP 750
Query: 1889 PESNGG-SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
+ P YI++++ + + VTV GS + + EI R+ AEN G
Sbjct: 751 MNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEI--RVQAENDFG 808
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI--AI 2005
E +SV +PS P +R + W PE G ++GY +
Sbjct: 809 KG--PEPESVIGYSGEDLPSAPRR-FRVRQPNLETINLEWDHPEHPNGI-MIGYTLKYVA 864
Query: 2006 RDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ TK V N KF ++ Y + AR ++G E + + P
Sbjct: 865 FNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 917
Score = 72.5 bits (170), Expect = 1e-11
Identities = 104/496 (20%), Positives = 184/496 (37%), Gaps = 36/496 (7%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F G P P + W+++G+ Y Y C+A N G+
Sbjct: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509
Query: 1559 VETSCVVGIQQKPVITISNED--------IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
E + ++ I ED ++ + +V + + + + E ++ N
Sbjct: 510 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR 569
Query: 1611 NKLENDKE--YNITTKEKTSV--IRIKELKRSHSSKY-TIEASNTAGTSSVEVTLKVYDK 1665
K E+D + + +++ S + EL + + Y T+ A T+ + K +
Sbjct: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPK--GR 627
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WIKVADVDRDV 1723
P +P + + +++ SV + W P D +T Y ++ E W + V
Sbjct: 628 PDRPRD-LELTDLAERSVRLTWIPG-DANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV 685
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+ + +L+ Y FRVIA N VG S +L SE +T+ P
Sbjct: 686 NS-AVLRLSPYVNYQFRVIAINEVGSSHPSLPSER--YRTSGAPPESNPGDVKGEGTRKN 742
Query: 1783 SVYITWFPSEKNGG-SPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRI 1839
++ ITW P P + Y V+ ++ + W + + + Y+ R+
Sbjct: 743 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV-VGQTPVYVPYEIRV 801
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N+ G P G+ L PS PR F V + ++ L+W PE G I
Sbjct: 802 QAENDFGKG-PEPESVIGYSGEDL--PSAPRRFRVRQPNLETINLEWDHPEHPNGIMI-G 857
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHE--HCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
Y +++ G K + S ++ ++ F +SA VG +S
Sbjct: 858 YTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 917
Query: 1958 RLEKHAT-VPSPPTAP 1972
AT +PPT P
Sbjct: 918 APPNEATPTAAPPTLP 933
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/303 (25%), Positives = 123/303 (40%), Gaps = 31/303 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 392
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 393 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 445
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 446 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 505
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 506 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 557
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+++E + I E+ L I V +E D G Y CVAS + A +T+ +
Sbjct: 558 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTVLAD 612
Query: 927 KVT 929
+ T
Sbjct: 613 QAT 615
Score = 67.7 bits (158), Expect = 4e-10
Identities = 132/604 (21%), Positives = 220/604 (36%), Gaps = 57/604 (9%)
Query: 633 PPTFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMH 689
PPT +K+ K VD +IL+EC P P W I D +S+ S
Sbjct: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ + + EG Y A N+ G A S I L++ P + ++P ++V++
Sbjct: 100 VI--DFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQE 154
Query: 749 GESVILSAQ-VVGNPRPTITWCKNN-KPV---KALPTKSDGDTHSITILKPKKVKDEG-- 801
G + L G P P I W ++ +P+ K + +GD + ++ D
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCN 214
Query: 802 -----VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+T++ +N T V+T E V + L
Sbjct: 215 ARFHFTHTIQQKN----PFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 270
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+ P P I WY+ + + +NF N L ITNV SE DSG+Y C+ASN G
Sbjct: 271 SGVPTPDIAWYKKGGDLPSDKAKFENF---NKALRITNV-SEEDSGEYFCLASNKMGSIR 326
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHRE 974
H +++ V+ + K+ G+ L C+ + + +W N + +
Sbjct: 327 H--TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNP 384
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIR-KLQDFEVK 1029
+E V +C ++ + + V + P + + Q V
Sbjct: 385 -NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI 443
Query: 1030 EKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
+ L+ S + W ++G+ Y + G + IR D+G Y+
Sbjct: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYT 500
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ + AE V V+ P I ++Q +G E + +L V W KD
Sbjct: 501 CVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
+ N ++ D L I+ D G Y+C E+ A LTV
Sbjct: 561 DEPLYIGNRMKKEDD----SLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATP 616
Query: 1199 TLRL 1202
T RL
Sbjct: 617 TNRL 620
Score = 60.1 bits (139), Expect = 9e-08
Identities = 146/705 (20%), Positives = 255/705 (36%), Gaps = 79/705 (11%)
Query: 828 ENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGE 886
E +PP + ++ V + I + NP PS W RN+ + ++ +
Sbjct: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95
Query: 887 NIELVI---TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT-FVKHLQKSYETEE 942
+ LVI + E G+Y+C A N G + R+ + V K + K +E
Sbjct: 96 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN-RIRLQVSKSPLWPKENLDPVVVQE 154
Query: 943 GKTVILECQTSHTVSTK---WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV-IK 998
G + L+C + + W + E D R + +G D+
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR--VSQGHNGDLYFSNVMLQDMQTDYS 212
Query: 999 C--------IVKDQETSTMLV-----VKETIPEFI----RKLQDFEVKEKDVAILEVEIN 1041
C ++ + T+ V V E P F+ ++ D+ + +
Sbjct: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
T D+ W + G + K K++ + L I N S D GEY C+ ++ + T
Sbjct: 273 VPTPDIAWYKKGGDLPSDKAKFE----NFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 328
Query: 1102 V---VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
+ V+ P + +N + G V+W +G +Q S +
Sbjct: 329 ISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNRE 387
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGN-------SKCTAILTVEEPSINFTLRLPEFILVPA 1210
+ D + Y C N + ++L V ++ +L IL
Sbjct: 388 VAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNR 447
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
P TL W+K D + + + +IRK +DQ YTCV
Sbjct: 448 TRLDCPFFGSPIPTL--RWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYTCV 502
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNS 1325
+ K+ ++++EV + P +I + +RG+ V L V + + W+ +
Sbjct: 503 ATNILGKAENQVRLEVKD-PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 561
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL-DKPSP- 1383
+ + K DS LTI V D G Y + +T+L D+ +P
Sbjct: 562 EPLYIGNRMKKEDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPT 617
Query: 1384 ----------PGKPNILEIDS---SSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWI 1428
P +P LE+ S+ + W P + NS I YVV+++E W
Sbjct: 618 NRLAALPKGRPDRPRDLELTDLAERSVRLTWI-PGDANNSPITDYVVQFEEDQFQPGVWH 676
Query: 1429 S-VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
K +++ L +Y+FR A+NEV S S +E Y+
Sbjct: 677 DHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYR 721
Score = 59.7 bits (138), Expect = 1e-07
Identities = 79/403 (19%), Positives = 153/403 (37%), Gaps = 24/403 (5%)
Query: 1287 PPKIVDYE-REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
PP I +++ + ++ + + + P P+ W NS+ K + S+ +S +L
Sbjct: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
Query: 1346 TIK-----KVENTDAGIYKLRLENNCGHA-DVEMNVTILDKPSPPGKPNILEI---DSSS 1396
I + E + G Y+ N G A + + + P P K N+ + + +
Sbjct: 100 VIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLWP-KENLDPVVVQEGAP 157
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQTSIQNLKTNSSYRFRA 1453
+ + + P + I + + I + +S + + + +Q+++T+ S R
Sbjct: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARF 217
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP---NEDIELTCIFGGVPQ 1510
+ + I + T + ++P+ P +++ D+ L CI GVP
Sbjct: 218 HFTHT--IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
Query: 1511 PKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ 1569
P + WY+ G L + KA +EN Y C+A N G + + V ++
Sbjct: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
Query: 1570 KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV 1629
P +E G++ + G P P V W NG L++ N +
Sbjct: 336 APYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP-NPNREVAGDT 392
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
I ++ + S + Y SN G + V D P + P
Sbjct: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 435
Score = 54.8 bits (126), Expect = 3e-06
Identities = 125/594 (21%), Positives = 226/594 (38%), Gaps = 64/594 (10%)
Query: 717 GEASLPIVLKIKTGEKEPPQVI-EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNK-- 773
G +P+ I+ +PP + + K IV +++++ + GNP P+ W +N++
Sbjct: 23 GAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF 82
Query: 774 PVKALPTKSDGDTHSITILK----PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
+ P S ++ + + EG Y A N G A ++ + + +
Sbjct: 83 NIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRI-----RLQVS 137
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRN-PVPSITWYRNN-EIISPSETITQNFDGEN 887
P + V+E + L P P I W ++ E I+ + ++Q G N
Sbjct: 138 KSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQ---GHN 194
Query: 888 IELVITNVDSEIDSGDYKCVA-----SNSAGKSSHGARV--TIDVEKVT----FVKHLQK 936
+L +NV + DY C A K+ +V T V + T + +
Sbjct: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTAS 254
Query: 937 SYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDV 994
S G ++LEC S T WY ++ D + E D
Sbjct: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKF--ENFNKALRITNVSEEDS 311
Query: 995 GVIKCIVKDQETS---TMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WE 1050
G C+ ++ S T+ V + P ++ + ++ + + L N V W
Sbjct: 312 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 371
Query: 1051 RDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----CTAEVTVVELP 1106
+GE ++ + E G + R+T + Y C +E A V+V+++P
Sbjct: 372 VNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
Query: 1107 PEIIT-RLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P +++ R Q +V N+ + +RWFK+G + ++K
Sbjct: 430 PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIK 489
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+ +D G Y+C +G ++ L V++P+ + R+PE + T L +
Sbjct: 490 M--IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIY--RMPEDQVARRGTTVQLECRV 545
Query: 1221 ---PDETLDVTWYKKKSVIEDTEKFTLISDVKKR--TLIIRKCTEDDQCEYTCV 1269
P L V+W K D E + + +KK +L I E DQ YTCV
Sbjct: 546 KHDPSLKLTVSWLK------DDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCV 593
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 261 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 316
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 317 LASNKMGSIRHTISVRVKA 335
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 449 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 505
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 506 ILGKAENQVRLEVKDP 521
Score = 38.7 bits (86), Expect = 0.23
Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS--VKNITKT 1436
D PS P + + + + +IN+ WD PE+ N +I Y ++Y + T+ V+N +
Sbjct: 823 DLPSAPRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGTKVGKQIVENFSPN 881
Query: 1437 QT--SIQNLKTNSSYRFRAYAVNEVDISDA 1464
QT ++Q S YRF A +V +A
Sbjct: 882 QTKFTVQRTDPVSRYRFTLSARTQVGSGEA 911
>AL391822-8|CAI14664.1| 1040|Homo sapiens neurofascin homolog
(chicken) protein.
Length = 1040
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 224 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 276
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 277 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 332
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 333 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 392
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 393 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 444
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 445 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 501
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 502 ARRGTTVQLECRVKHDPSLK 521
Score = 116 bits (279), Expect = 9e-25
Identities = 138/593 (23%), Positives = 233/593 (39%), Gaps = 42/593 (7%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXX---XXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 313 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 372
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 373 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 432
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 433 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 490
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLD-DGGLELTKYAIEKHEP--DNNRWIKVAD---- 1718
P +++R T++ + + D L+LT ++ EP NR K D
Sbjct: 491 TRIYRMPE--DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI 548
Query: 1719 ---VDRDVETY-CIQ--KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
+RD +Y C+ +L+++ + + + + L + P K D P
Sbjct: 549 FGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALP---KGRPDRPRDLEL 605
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXX-XXXXARIQK 1828
+ SV +TW P + N SPI DY V+ +++ + W + + +
Sbjct: 606 TD----LAERSVRLTWIPGDANN-SPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLR 660
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
LS YQFR+ A NE+G+S P ++ P S P + + ++ + WT
Sbjct: 661 LSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGA-PPESNPGDVKGEGTRKNNMEITWTP 719
Query: 1889 PESNGG-SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
+ P YI++++ + + VTV GS + + EI R+ AEN G
Sbjct: 720 MNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEI--RVQAENDFG 777
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI--AI 2005
E +SV +PS P +R + W PE G ++GY +
Sbjct: 778 KG--PEPESVIGYSGEDLPSAPRR-FRVRQPNLETINLEWDHPEHPNGI-MIGYTLKYVA 833
Query: 2006 RDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ TK V N KF ++ Y + AR ++G E + + P
Sbjct: 834 FNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 886
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/303 (25%), Positives = 123/303 (40%), Gaps = 31/303 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 306 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 361
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 362 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 414
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 415 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 474
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 475 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 526
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+++E + I E+ L I V +E D G Y CVAS + A +T+ +
Sbjct: 527 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTVLAD 581
Query: 927 KVT 929
+ T
Sbjct: 582 QAT 584
Score = 67.7 bits (158), Expect = 4e-10
Identities = 132/604 (21%), Positives = 220/604 (36%), Gaps = 57/604 (9%)
Query: 633 PPTFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMH 689
PPT +K+ K VD +IL+EC P P W I D +S+ S
Sbjct: 9 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 68
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ + + EG Y A N+ G A S I L++ P + ++P ++V++
Sbjct: 69 VI--DFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQE 123
Query: 749 GESVILSAQ-VVGNPRPTITWCKNN-KPV---KALPTKSDGDTHSITILKPKKVKDEG-- 801
G + L G P P I W ++ +P+ K + +GD + ++ D
Sbjct: 124 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCN 183
Query: 802 -----VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+T++ +N T V+T E V + L
Sbjct: 184 ARFHFTHTIQQKN----PFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 239
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+ P P I WY+ + + +NF N L ITNV SE DSG+Y C+ASN G
Sbjct: 240 SGVPTPDIAWYKKGGDLPSDKAKFENF---NKALRITNV-SEEDSGEYFCLASNKMGSIR 295
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHRE 974
H +++ V+ + K+ G+ L C+ + + +W N + +
Sbjct: 296 H--TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNP 353
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIR-KLQDFEVK 1029
+E V +C ++ + + V + P + + Q V
Sbjct: 354 -NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI 412
Query: 1030 EKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
+ L+ S + W ++G+ Y + G + IR D+G Y+
Sbjct: 413 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYT 469
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ + AE V V+ P I ++Q +G E + +L V W KD
Sbjct: 470 CVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 529
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
+ N ++ D L I+ D G Y+C E+ A LTV
Sbjct: 530 DEPLYIGNRMKKEDD----SLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATP 585
Query: 1199 TLRL 1202
T RL
Sbjct: 586 TNRL 589
Score = 66.9 bits (156), Expect = 7e-10
Identities = 100/487 (20%), Positives = 179/487 (36%), Gaps = 35/487 (7%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F G P P + W+++G+ Y Y C+A N G+
Sbjct: 419 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 478
Query: 1559 VETSCVVGIQQKPVITISNED--------IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
E + ++ I ED ++ + +V + + + + E ++ N
Sbjct: 479 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR 538
Query: 1611 NKLENDKE--YNITTKEKTSV--IRIKELKRSHSSKY-TIEASNTAGTSSVEVTLKVYDK 1665
K E+D + + +++ S + EL + + Y T+ A T+ + K +
Sbjct: 539 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPK--GR 596
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WIKVADVDRDV 1723
P +P + + +++ SV + W P D +T Y ++ E W + V
Sbjct: 597 PDRPRD-LELTDLAERSVRLTWIPG-DANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV 654
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+ + +L+ Y FRVIA N VG S +L SE +T+ P
Sbjct: 655 NS-AVLRLSPYVNYQFRVIAINEVGSSHPSLPSER--YRTSGAPPESNPGDVKGEGTRKN 711
Query: 1783 SVYITWFPSEKNGG-SPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRI 1839
++ ITW P P + Y V+ ++ + W + + + Y+ R+
Sbjct: 712 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV-VGQTPVYVPYEIRV 770
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N+ G P G+ L PS PR F V + ++ L+W PE G I
Sbjct: 771 QAENDFGKG-PEPESVIGYSGEDL--PSAPRRFRVRQPNLETINLEWDHPEHPNGIMI-G 826
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHE--HCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
Y +++ G K + S ++ ++ F +SA VG +S
Sbjct: 827 YTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 886
Query: 1958 RLEKHAT 1964
AT
Sbjct: 887 APPNEAT 893
Score = 60.1 bits (139), Expect = 9e-08
Identities = 146/705 (20%), Positives = 255/705 (36%), Gaps = 79/705 (11%)
Query: 828 ENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGE 886
E +PP + ++ V + I + NP PS W RN+ + ++ +
Sbjct: 5 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 64
Query: 887 NIELVI---TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT-FVKHLQKSYETEE 942
+ LVI + E G+Y+C A N G + R+ + V K + K +E
Sbjct: 65 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN-RIRLQVSKSPLWPKENLDPVVVQE 123
Query: 943 GKTVILECQTSHTVSTK---WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV-IK 998
G + L+C + + W + E D R + +G D+
Sbjct: 124 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR--VSQGHNGDLYFSNVMLQDMQTDYS 181
Query: 999 C--------IVKDQETSTMLV-----VKETIPEFI----RKLQDFEVKEKDVAILEVEIN 1041
C ++ + T+ V V E P F+ ++ D+ + +
Sbjct: 182 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 241
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
T D+ W + G + K K++ + L I N S D GEY C+ ++ + T
Sbjct: 242 VPTPDIAWYKKGGDLPSDKAKFE----NFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 297
Query: 1102 V---VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
+ V+ P + +N + G V+W +G +Q S +
Sbjct: 298 ISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNRE 356
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGN-------SKCTAILTVEEPSINFTLRLPEFILVPA 1210
+ D + Y C N + ++L V ++ +L IL
Sbjct: 357 VAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNR 416
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
P TL W+K D + + + +IRK +DQ YTCV
Sbjct: 417 TRLDCPFFGSPIPTL--RWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYTCV 471
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNS 1325
+ K+ ++++EV + P +I + +RG+ V L V + + W+ +
Sbjct: 472 ATNILGKAENQVRLEVKD-PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 530
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL-DKPSP- 1383
+ + K DS LTI V D G Y + +T+L D+ +P
Sbjct: 531 EPLYIGNRMKKEDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPT 586
Query: 1384 ----------PGKPNILEIDS---SSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWI 1428
P +P LE+ S+ + W P + NS I YVV+++E W
Sbjct: 587 NRLAALPKGRPDRPRDLELTDLAERSVRLTWI-PGDANNSPITDYVVQFEEDQFQPGVWH 645
Query: 1429 S-VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
K +++ L +Y+FR A+NEV S S +E Y+
Sbjct: 646 DHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYR 690
Score = 59.7 bits (138), Expect = 1e-07
Identities = 79/403 (19%), Positives = 153/403 (37%), Gaps = 24/403 (5%)
Query: 1287 PPKIVDYE-REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
PP I +++ + ++ + + + P P+ W NS+ K + S+ +S +L
Sbjct: 9 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 68
Query: 1346 TIK-----KVENTDAGIYKLRLENNCGHA-DVEMNVTILDKPSPPGKPNILEI---DSSS 1396
I + E + G Y+ N G A + + + P P K N+ + + +
Sbjct: 69 VIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLWP-KENLDPVVVQEGAP 126
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQTSIQNLKTNSSYRFRA 1453
+ + + P + I + + I + +S + + + +Q+++T+ S R
Sbjct: 127 LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARF 186
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP---NEDIELTCIFGGVPQ 1510
+ + I + T + ++P+ P +++ D+ L CI GVP
Sbjct: 187 HFTHT--IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 244
Query: 1511 PKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ 1569
P + WY+ G L + KA +EN Y C+A N G + + V ++
Sbjct: 245 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 304
Query: 1570 KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV 1629
P +E G++ + G P P V W NG L++ N +
Sbjct: 305 APYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP-NPNREVAGDT 361
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
I ++ + S + Y SN G + V D P + P
Sbjct: 362 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 404
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 230 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 285
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 286 LASNKMGSIRHTISVRVKA 304
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 418 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 474
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 475 ILGKAENQVRLEVKDP 490
Score = 38.7 bits (86), Expect = 0.23
Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS--VKNITKT 1436
D PS P + + + + +IN+ WD PE+ N +I Y ++Y + T+ V+N +
Sbjct: 792 DLPSAPRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGTKVGKQIVENFSPN 850
Query: 1437 QT--SIQNLKTNSSYRFRAYAVNEVDISDA 1464
QT ++Q S YRF A +V +A
Sbjct: 851 QTKFTVQRTDPVSRYRFTLSARTQVGSGEA 880
>AL391822-7|CAI14662.1| 1165|Homo sapiens neurofascin homolog
(chicken) protein.
Length = 1165
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 242 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 294
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 295 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 350
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 351 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 410
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 411 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 462
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 463 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 519
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 520 ARRGTTVQLECRVKHDPSLK 539
Score = 101 bits (242), Expect = 3e-20
Identities = 121/520 (23%), Positives = 205/520 (39%), Gaps = 38/520 (7%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXX---XXXXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 331 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 390
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 391 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 450
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 451 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 508
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPL-DDGGLELTKYAIEKHEP--DNNRWIKVAD---- 1718
P +++R T++ + + D L+LT ++ EP NR K D
Sbjct: 509 TRIYRMP--EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI 566
Query: 1719 ---VDRDVETY-CI--QKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
+RD +Y C+ +L+++ + + + + L + P K D P
Sbjct: 567 FGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALP---KGRPDRP----R 619
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK----QEGKKWKXXXXXXXXXARIQK 1828
+ SV +TW P + N SPI DY V+ + Q G + + +
Sbjct: 620 DLELTDLAERSVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLR 678
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
LS YQFR+ A NE+G+S P ++ P S P + + ++ + WT
Sbjct: 679 LSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGA-PPESNPGDVKGEGTRKNNMEITWTP 737
Query: 1889 PESNGG-SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
+ P YI++++ + + VTV GS + + EI R+ AEN G
Sbjct: 738 MNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEI--RVQAENDFG 795
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSW 1987
E +SV P +++R++ S + W
Sbjct: 796 KG--PEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQW 833
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/303 (25%), Positives = 123/303 (40%), Gaps = 31/303 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 324 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 379
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 380 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 432
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 433 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 492
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 493 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 544
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+++E + I E+ L I V +E D G Y CVAS + A +T+ +
Sbjct: 545 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTVLAD 599
Query: 927 KVT 929
+ T
Sbjct: 600 QAT 602
Score = 62.9 bits (146), Expect = 1e-08
Identities = 117/589 (19%), Positives = 215/589 (36%), Gaps = 45/589 (7%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F G P P + W+++G+ Y Y C+A N G+
Sbjct: 437 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 496
Query: 1559 VETSCVVGIQQKPVITISNED--------IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
E + ++ I ED ++ + +V + + + + E ++ N
Sbjct: 497 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR 556
Query: 1611 NKLENDKE--YNITTKEKTSV--IRIKELKRSHSSKY-TIEASNTAGTSSVEVTLKVYDK 1665
K E+D + + +++ S + EL + + Y T+ A T+ + K +
Sbjct: 557 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPK--GR 614
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WIKVADVDRDV 1723
P +P + + +++ SV + W P D +T Y ++ E W + V
Sbjct: 615 PDRPRD-LELTDLAERSVRLTWIPG-DANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV 672
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+ + +L+ Y FRVIA N VG S +L SE +T+ P
Sbjct: 673 NS-AVLRLSPYVNYQFRVIAINEVGSSHPSLPSER--YRTSGAPPESNPGDVKGEGTRKN 729
Query: 1783 SVYITWFPSEKNGG-SPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRI 1839
++ ITW P P + Y V+ ++ + W + + + Y+ R+
Sbjct: 730 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV-VGQTPVYVPYEIRV 788
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N+ G P + I P + P V S +++L+W S+ +
Sbjct: 789 QAENDFGKG-P-EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD---TVQG 843
Query: 1900 YIIEFKTV--KGKSWTKIVTVGGSVHEHCIENIKEKDEI--IFRISAENTVGVSLPTESQ 1955
+ E++ + S K + V + + + + +F S V +
Sbjct: 844 QLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGD 903
Query: 1956 SVRLE-KHATVP-SPPTAPLEIRMVGSNI--VMTSWGTPEWDGGAPLLGYNI--AIRDVT 2009
R E K T P P+AP R+ N+ + W PE G ++GY + + T
Sbjct: 904 GPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGI-MIGYTLKYVAFNGT 962
Query: 2010 KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
K V N KF ++ Y + AR ++G E + + P
Sbjct: 963 KVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1011
Score = 58.8 bits (136), Expect = 2e-07
Identities = 44/176 (25%), Positives = 67/176 (38%), Gaps = 4/176 (2%)
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDH 1556
D+ L CI GVP P + WY+ G L + KA +EN Y C+A N
Sbjct: 250 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKM 309
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
G + + V ++ P +E G++ + G P P V W NG L++
Sbjct: 310 GSIRHTISVRVKAAPYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSA 367
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
N + I ++ + S + Y SN G + V D P + P
Sbjct: 368 PP-NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 422
Score = 57.2 bits (132), Expect = 6e-07
Identities = 131/617 (21%), Positives = 230/617 (37%), Gaps = 66/617 (10%)
Query: 633 PPTFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMH 689
PPT +K+ K VD +IL+EC P P W I D +S+ S
Sbjct: 10 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 69
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ + + EG Y A N+ G A S I L++ P + ++P ++V++
Sbjct: 70 VI--DFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQE 124
Query: 749 GESVILSAQ-VVGNPRPTITWCKNN-KPV---KALPTKSDGDTH-SITILKPKK------ 796
G + L G P P I W ++ +P+ K + +GD + S +L+ +
Sbjct: 125 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCN 184
Query: 797 --------VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
++ + +TLK + ++S + + + + T +
Sbjct: 185 ARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQM 244
Query: 849 TIK---LVARVTRNPVPS--ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
++ L+ + VP+ I WY+ + + +NF N L ITNV SE DSG+
Sbjct: 245 VLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENF---NKALRITNV-SEEDSGE 300
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWY 961
Y C+ASN G H +++ V+ + K+ G+ L C+ + + +W
Sbjct: 301 YFCLASNKMGSIRH--TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 358
Query: 962 HNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIP 1017
N + + +E V +C ++ + + V + P
Sbjct: 359 VNGEPLQSAPPNP-NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 417
Query: 1018 EFIR-KLQDFEVKEKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
+ + Q V + L+ S + W ++G+ Y + G +
Sbjct: 418 RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 477
Query: 1076 IRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTK 1132
IR D+G Y+C+ + AE V V+ P I ++Q +G E +
Sbjct: 478 IRK---EDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKH 534
Query: 1133 GDAL---VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKC 1185
+L V W KD + N ++ D L I+ D G Y+C E+
Sbjct: 535 DPSLKLTVSWLKDDEPLYIGNRMKKEDD----SLTIFGVAERDQGSYTCVASTELDQDLA 590
Query: 1186 TAILTVEEPSINFTLRL 1202
A LTV T RL
Sbjct: 591 KAYLTVLADQATPTNRL 607
Score = 52.8 bits (121), Expect = 1e-05
Identities = 102/463 (22%), Positives = 173/463 (37%), Gaps = 50/463 (10%)
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
T D+ W + G + K K++ + L I N S D GEY C+ ++ + T+
Sbjct: 262 TPDIAWYKKGGDLPSDKAKFE----NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 317
Query: 1103 --VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGK 1159
V+ P + +N + G V+W +G +Q S +
Sbjct: 318 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 376
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGN-------SKCTAILTVEEPSINFTLRLPEFILVPANT 1212
+ D + Y C N + ++L V ++ +L IL
Sbjct: 377 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 436
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
P TL W+K D + + + +IRK +DQ YTCV
Sbjct: 437 LDCPFFGSPIPTL--RWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYTCVAT 491
Query: 1272 D--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKI 1327
+ K+ ++++EV + P +I + +RG+ V L V + + W+ + +
Sbjct: 492 NILGKAENQVRLEVKD-PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 550
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL-DKPSP--- 1383
+ K DS LTI V D G Y + +T+L D+ +P
Sbjct: 551 LYIGNRMKKEDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNR 606
Query: 1384 --------PGKPNILEIDS---SSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWIS- 1429
P +P LE+ S+ + W P + NS I YVV+++E W
Sbjct: 607 LAALPKGRPDRPRDLELTDLAERSVRLTWI-PGDANNSPITDYVVQFEEDQFQPGVWHDH 665
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
K +++ L +Y+FR A+NEV S S +E Y+
Sbjct: 666 SKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYR 708
Score = 52.4 bits (120), Expect = 2e-05
Identities = 68/267 (25%), Positives = 110/267 (41%), Gaps = 28/267 (10%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P +PR+ +++ RSV L W ++N SPIT+Y+++F+ + + W GSV+
Sbjct: 615 PDRPRDLELTDLAERSVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN 673
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTA-PLEIRMVGS-- 1980
+ + FR+ A N VG S P S+ E++ T +PP + P +++ G+
Sbjct: 674 S-AVLRLSPYVNYQFRVIAINEVGSSHP----SLPSERYRTSGAPPESNPGDVKGEGTRK 728
Query: 1981 NIVMTSWGTP--EWDGGAPLLGYNIA-IRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTY 2037
N + +W TP P L Y + R T+ W V V ++ + Y
Sbjct: 729 NNMEITW-TPMNATSAFGPNLRYIVKWRRRETREAW---NNVTVWGSRYVVGQTPVYVPY 784
Query: 2038 MIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLREH 2097
IR+ A N+ G + EP VI G D TEV W R +
Sbjct: 785 EIRVQAENDFG-----KGPEPESVIGYSGE--DYPRAAPTEVKVRVMNSTAISLQWNRVY 837
Query: 2098 N--MDADIRSYARGSLLRRDEYFFRIW 2122
+ + +R Y R R +W
Sbjct: 838 SDTVQGQLREY-RAYYWRESSLLKNLW 863
Score = 43.6 bits (98), Expect = 0.008
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + G+P P++ WYK G L +DK + +RI + S +Y
Sbjct: 248 GMDLLLECIASGVPTPDIAWYKKGGDLPSDK---AKFENFNKALRITNVSEEDSGEYFCL 304
Query: 1647 ASNTAGTSSVEVTLKVYDKP 1666
ASN G+ ++++V P
Sbjct: 305 ASNKMGSIRHTISVRVKAAP 324
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 248 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 303
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 304 LASNKMGSIRHTISVRVKA 322
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 436 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 492
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 493 ILGKAENQVRLEVKDP 508
Score = 37.1 bits (82), Expect = 0.69
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 5/88 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS--VKNITKTQT 1438
PS P + + + + +IN+ WD PE+ N +I Y ++Y + T+ V+N + QT
Sbjct: 919 PSAPRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGTKVGKQIVENFSPNQT 977
Query: 1439 --SIQNLKTNSSYRFRAYAVNEVDISDA 1464
++Q S YRF A +V +A
Sbjct: 978 KFTVQRTDPVSRYRFTLSARTQVGSGEA 1005
Score = 34.7 bits (76), Expect = 3.7
Identities = 30/133 (22%), Positives = 54/133 (40%), Gaps = 5/133 (3%)
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
+E P + P + ++ V + I + NP PS W RN+ + ++
Sbjct: 1 IEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRV 60
Query: 882 NFDGENIELVI---TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK-VTFVKHLQKS 937
+ + LVI + E G+Y+C A N G ++ R+ + V K + K
Sbjct: 61 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDP 119
Query: 938 YETEEGKTVILEC 950
+EG + L+C
Sbjct: 120 VVVQEGAPLTLQC 132
>AL391822-6|CAI14661.1| 1157|Homo sapiens neurofascin homolog
(chicken) protein.
Length = 1157
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 249 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 301
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 302 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 357
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 358 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 417
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 418 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 469
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 470 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 526
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 527 ARRGTTVQLECRVKHDPSLK 546
Score = 99.1 bits (236), Expect = 2e-19
Identities = 115/510 (22%), Positives = 200/510 (39%), Gaps = 33/510 (6%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXX---XXXXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 338 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 397
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 398 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 457
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 458 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 515
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPL-DDGGLELTKYAIEKHEP--DNNRWIKVADVDRD 1722
P +++R T++ + + D L+LT ++ EP NR + ++
Sbjct: 516 TRIYRMP--EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR------MKKE 567
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
++ I + E + + +A + + L + + D P +
Sbjct: 568 DDSLTIFGVAERDQGSYTCVASTEL--DQDLAKAYLTVLGRPDRP----RDLELTDLAER 621
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIK----QEGKKWKXXXXXXXXXARIQKLSINTTYQFR 1838
SV +TW P + N SPI DY V+ + Q G + + +LS YQFR
Sbjct: 622 SVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFR 680
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG-SPI 1897
+ A NE+G+S P ++ P S P + + ++ + WT + P
Sbjct: 681 VIAINEVGSSHPSLPSERYRTSGA-PPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPN 739
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
YI++++ + + VTV GS + + EI R+ AEN G E +SV
Sbjct: 740 LRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEI--RVQAENDFGKG--PEPESV 795
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSW 1987
P +++R++ S + W
Sbjct: 796 IGYSGEDYPRAAPTEVKVRVMNSTAISLQW 825
Score = 74.1 bits (174), Expect = 5e-12
Identities = 142/695 (20%), Positives = 252/695 (36%), Gaps = 63/695 (9%)
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
+E P + P + ++ V + I + NP PS W RN+ + ++
Sbjct: 25 IEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRV 84
Query: 882 NFDGENIELVI---TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT-FVKHLQKS 937
+ + LVI + E G+Y+C A N G + R+ + V K + K
Sbjct: 85 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN-RIRLQVSKSPLWPKENLDP 143
Query: 938 YETEEGKTVILECQTSHTVSTK---WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDV 994
+EG + L+C + + W + E D R + +G D+
Sbjct: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR--VSQGHNGDLYFSNVMLQDM 201
Query: 995 GV-IKC--------IVKDQETSTMLV-----VKETIPEFI----RKLQDFEVKEKDVAIL 1036
C ++ + T+ V V E P F+ ++ D+ +
Sbjct: 202 QTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLE 261
Query: 1037 EVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESC 1096
+ T D+ W + G + K K++ + L I N S D GEY C+ ++
Sbjct: 262 CIASGVPTPDIAWYKKGGDLPSDKAKFE----NFNKALRITNVSEEDSGEYFCLASNKMG 317
Query: 1097 TAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHI 1152
+ T+ V+ P + +N + G V+W +G +Q S
Sbjct: 318 SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPP 376
Query: 1153 QLTIDGKKQKLKIYDCDLDDAGEYSCEVGN-------SKCTAILTVEEPSINFTLRLPEF 1205
+ + D + Y C N + ++L V ++ +L
Sbjct: 377 NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRV 436
Query: 1206 ILVPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQC 1264
IL P TL W+K D + + + +IRK +DQ
Sbjct: 437 ILYNRTRLDCPFFGSPIPTL--RWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQG 491
Query: 1265 EYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDE 1320
YTCV + K+ ++++EV + P +I + +RG+ V L V + +
Sbjct: 492 IYTCVATNILGKAENQVRLEVKD-PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVS 550
Query: 1321 WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
W+ + + + K DS LTI V D G Y + +T+L +
Sbjct: 551 WLKDDEPLYIGNRMKKEDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGR 606
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWIS-VKNITKTQ 1437
P P + ++ S+ + W P + NS I YVV+++E W K
Sbjct: 607 PDRPRDLELTDLAERSVRLTWI-PGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN 665
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
+++ L +Y+FR A+NEV S S +E Y+
Sbjct: 666 SAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYR 700
Score = 68.9 bits (161), Expect = 2e-10
Identities = 122/578 (21%), Positives = 207/578 (35%), Gaps = 38/578 (6%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F G P P + W+++G+ Y Y C+A N G+
Sbjct: 444 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 503
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE--VIWYKNGNKLEND 1616
E + ++ I ED Q + G + ++ P + V W K+ L
Sbjct: 504 AENQVRLEVKDPTRIYRMPED--QVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 561
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
N KE S+ +R S YT AS + L V +P +P + +
Sbjct: 562 ---NRMKKEDDSLTIFGVAERDQGS-YTCVASTELDQDLAKAYLTVLGRPDRPRD-LELT 616
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WIKVADVDRDVETYCIQKLNEN 1734
+++ SV + W P D +T Y ++ E W + V + + +L+
Sbjct: 617 DLAERSVRLTWIPG-DANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNS-AVLRLSPY 674
Query: 1735 CEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEK 1793
Y FRVIA N VG S +L SE +T+ P ++ ITW P
Sbjct: 675 VNYQFRVIAINEVGSSHPSLPSER--YRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNA 732
Query: 1794 NGG-SPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
P + Y V+ ++ + W + + + Y+ R+ A N+ G P
Sbjct: 733 TSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV-VGQTPVYVPYEIRVQAENDFGKG-P 790
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTV--K 1908
+ I P + P V S +++L+W S+ + + E++ +
Sbjct: 791 -EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD---TVQGQLREYRAYYWR 846
Query: 1909 GKSWTKIVTVGGSVHEHCIENIKEKDEI--IFRISAENTVGVSLPTESQSVRLE-KHATV 1965
S K + V + + + + +F S V + R E K T
Sbjct: 847 ESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTT 906
Query: 1966 P-SPPTAPLEIRMVGSNI--VMTSWGTPEWDGGAPLLGYNI--AIRDVTKTMWMEVGKVD 2020
P P+AP R+ N+ + W PE G ++GY + + TK V
Sbjct: 907 PEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGI-MIGYTLKYVAFNGTKVGKQIVENFS 965
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
N KF ++ Y + AR ++G E + + P
Sbjct: 966 PNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1003
Score = 67.7 bits (158), Expect = 4e-10
Identities = 75/297 (25%), Positives = 120/297 (40%), Gaps = 31/297 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 331 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 386
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 387 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 439
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 440 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 499
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 500 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 551
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+++E + I E+ L I V +E D G Y CVAS + A +T+
Sbjct: 552 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTV 603
Score = 67.3 bits (157), Expect = 6e-10
Identities = 129/593 (21%), Positives = 217/593 (36%), Gaps = 57/593 (9%)
Query: 633 PPTFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMH 689
PPT +K+ K VD +IL+EC P P W I D +S+ S
Sbjct: 34 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 93
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ + + EG Y A N+ G A S I L++ P + ++P ++V++
Sbjct: 94 VI--DFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQE 148
Query: 749 GESVILSAQ-VVGNPRPTITWCKNN-KPV---KALPTKSDGDTHSITILKPKKVKDEG-- 801
G + L G P P I W ++ +P+ K + +GD + ++ D
Sbjct: 149 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCN 208
Query: 802 -----VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+T++ +N T V+T E V + L
Sbjct: 209 ARFHFTHTIQQKN----PFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 264
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+ P P I WY+ + + +NF N L ITNV SE DSG+Y C+ASN G
Sbjct: 265 SGVPTPDIAWYKKGGDLPSDKAKFENF---NKALRITNV-SEEDSGEYFCLASNKMGSIR 320
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHRE 974
H +++ V+ + K+ G+ L C+ + + +W N + +
Sbjct: 321 H--TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNP 378
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIR-KLQDFEVK 1029
+E V +C ++ + + V + P + + Q V
Sbjct: 379 -NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI 437
Query: 1030 EKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
+ L+ S + W ++G+ Y + G + IR D+G Y+
Sbjct: 438 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYT 494
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ + AE V V+ P I ++Q +G E + +L V W KD
Sbjct: 495 CVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 554
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTV 1191
+ N ++ D L I+ D G Y+C E+ A LTV
Sbjct: 555 DEPLYIGNRMKKEDD----SLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
Score = 60.1 bits (139), Expect = 9e-08
Identities = 79/419 (18%), Positives = 159/419 (37%), Gaps = 23/419 (5%)
Query: 1270 LLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIK 1329
LL ++ +++ + P +++ + ++ + + + P P+ W NS+
Sbjct: 18 LLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 77
Query: 1330 KCKHTKPSIDSKSASLTIK-----KVENTDAGIYKLRLENNCGHA-DVEMNVTILDKPSP 1383
K + S+ +S +L I + E + G Y+ N G A + + + P
Sbjct: 78 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLW 136
Query: 1384 PGKPNILEI---DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P K N+ + + + + + + P + I + + I + +S + + +
Sbjct: 137 P-KENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSN 195
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP-- 1495
+Q+++T+ S R + + I + T + ++P+ P +++
Sbjct: 196 VMLQDMQTDYSCNARFHFTHT--IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVL 253
Query: 1496 -NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAF 1553
D+ L CI GVP P + WY+ G L + KA +EN Y C+A
Sbjct: 254 RGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLAS 313
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKL 1613
N G + + V ++ P +E G++ + G P P V W NG L
Sbjct: 314 NKMGSIRHTISVRVKAAPYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPL 371
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
++ N + I ++ + S + Y SN G + V D P + P
Sbjct: 372 QSAPP-NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 429
Score = 52.4 bits (120), Expect = 2e-05
Identities = 68/267 (25%), Positives = 110/267 (41%), Gaps = 28/267 (10%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P +PR+ +++ RSV L W ++N SPIT+Y+++F+ + + W GSV+
Sbjct: 607 PDRPRDLELTDLAERSVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN 665
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTA-PLEIRMVGS-- 1980
+ + FR+ A N VG S P S+ E++ T +PP + P +++ G+
Sbjct: 666 S-AVLRLSPYVNYQFRVIAINEVGSSHP----SLPSERYRTSGAPPESNPGDVKGEGTRK 720
Query: 1981 NIVMTSWGTP--EWDGGAPLLGYNIA-IRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTY 2037
N + +W TP P L Y + R T+ W V V ++ + Y
Sbjct: 721 NNMEITW-TPMNATSAFGPNLRYIVKWRRRETREAW---NNVTVWGSRYVVGQTPVYVPY 776
Query: 2038 MIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLREH 2097
IR+ A N+ G + EP VI G D TEV W R +
Sbjct: 777 EIRVQAENDFG-----KGPEPESVIGYSGE--DYPRAAPTEVKVRVMNSTAISLQWNRVY 829
Query: 2098 N--MDADIRSYARGSLLRRDEYFFRIW 2122
+ + +R Y R R +W
Sbjct: 830 SDTVQGQLREY-RAYYWRESSLLKNLW 855
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 255 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 310
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 311 LASNKMGSIRHTISVRVKA 329
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 443 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 499
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 500 ILGKAENQVRLEVKDP 515
Score = 37.1 bits (82), Expect = 0.69
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 5/88 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS--VKNITKTQT 1438
PS P + + + + +IN+ WD PE+ N +I Y ++Y + T+ V+N + QT
Sbjct: 911 PSAPRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGTKVGKQIVENFSPNQT 969
Query: 1439 --SIQNLKTNSSYRFRAYAVNEVDISDA 1464
++Q S YRF A +V +A
Sbjct: 970 KFTVQRTDPVSRYRFTLSARTQVGSGEA 997
>AL391822-5|CAI14659.1| 1240|Homo sapiens neurofascin homolog
(chicken) protein.
Length = 1240
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 307
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 308 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 363
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 364 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 423
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 424 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 475
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 476 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 532
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 533 ARRGTTVQLECRVKHDPSLK 552
Score = 116 bits (279), Expect = 9e-25
Identities = 138/593 (23%), Positives = 233/593 (39%), Gaps = 42/593 (7%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXX---XXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 464 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLD-DGGLELTKYAIEKHEP--DNNRWIKVAD---- 1718
P +++R T++ + + D L+LT ++ EP NR K D
Sbjct: 522 TRIYRMPE--DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI 579
Query: 1719 ---VDRDVETY-CIQ--KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
+RD +Y C+ +L+++ + + + + L + P K D P
Sbjct: 580 FGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALP---KGRPDRPRDLEL 636
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXX-XXXXARIQK 1828
+ SV +TW P + N SPI DY V+ +++ + W + + +
Sbjct: 637 TD----LAERSVRLTWIPGDANN-SPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLR 691
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
LS YQFR+ A NE+G+S P ++ P S P + + ++ + WT
Sbjct: 692 LSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGA-PPESNPGDVKGEGTRKNNMEITWTP 750
Query: 1889 PESNGG-SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
+ P YI++++ + + VTV GS + + EI R+ AEN G
Sbjct: 751 MNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEI--RVQAENDFG 808
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI--AI 2005
E +SV +PS P +R + W PE G ++GY +
Sbjct: 809 KG--PEPESVIGYSGEDLPSAPRR-FRVRQPNLETINLEWDHPEHPNGI-MIGYTLKYVA 864
Query: 2006 RDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ TK V N KF ++ Y + AR ++G E + + P
Sbjct: 865 FNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 917
Score = 72.5 bits (170), Expect = 1e-11
Identities = 104/496 (20%), Positives = 184/496 (37%), Gaps = 36/496 (7%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F G P P + W+++G+ Y Y C+A N G+
Sbjct: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509
Query: 1559 VETSCVVGIQQKPVITISNED--------IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
E + ++ I ED ++ + +V + + + + E ++ N
Sbjct: 510 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR 569
Query: 1611 NKLENDKE--YNITTKEKTSV--IRIKELKRSHSSKY-TIEASNTAGTSSVEVTLKVYDK 1665
K E+D + + +++ S + EL + + Y T+ A T+ + K +
Sbjct: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPK--GR 627
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WIKVADVDRDV 1723
P +P + + +++ SV + W P D +T Y ++ E W + V
Sbjct: 628 PDRPRD-LELTDLAERSVRLTWIPG-DANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV 685
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+ + +L+ Y FRVIA N VG S +L SE +T+ P
Sbjct: 686 NS-AVLRLSPYVNYQFRVIAINEVGSSHPSLPSER--YRTSGAPPESNPGDVKGEGTRKN 742
Query: 1783 SVYITWFPSEKNGG-SPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRI 1839
++ ITW P P + Y V+ ++ + W + + + Y+ R+
Sbjct: 743 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV-VGQTPVYVPYEIRV 801
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N+ G P G+ L PS PR F V + ++ L+W PE G I
Sbjct: 802 QAENDFGKG-PEPESVIGYSGEDL--PSAPRRFRVRQPNLETINLEWDHPEHPNGIMI-G 857
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHE--HCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
Y +++ G K + S ++ ++ F +SA VG +S
Sbjct: 858 YTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 917
Query: 1958 RLEKHAT-VPSPPTAP 1972
AT +PPT P
Sbjct: 918 APPNEATPTAAPPTLP 933
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/303 (25%), Positives = 123/303 (40%), Gaps = 31/303 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 392
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 393 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 445
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 446 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 505
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 506 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 557
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+++E + I E+ L I V +E D G Y CVAS + A +T+ +
Sbjct: 558 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTVLAD 612
Query: 927 KVT 929
+ T
Sbjct: 613 QAT 615
Score = 67.7 bits (158), Expect = 4e-10
Identities = 132/604 (21%), Positives = 220/604 (36%), Gaps = 57/604 (9%)
Query: 633 PPTFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMH 689
PPT +K+ K VD +IL+EC P P W I D +S+ S
Sbjct: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ + + EG Y A N+ G A S I L++ P + ++P ++V++
Sbjct: 100 VI--DFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQE 154
Query: 749 GESVILSAQ-VVGNPRPTITWCKNN-KPV---KALPTKSDGDTHSITILKPKKVKDEG-- 801
G + L G P P I W ++ +P+ K + +GD + ++ D
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCN 214
Query: 802 -----VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+T++ +N T V+T E V + L
Sbjct: 215 ARFHFTHTIQQKN----PFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 270
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+ P P I WY+ + + +NF N L ITNV SE DSG+Y C+ASN G
Sbjct: 271 SGVPTPDIAWYKKGGDLPSDKAKFENF---NKALRITNV-SEEDSGEYFCLASNKMGSIR 326
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHRE 974
H +++ V+ + K+ G+ L C+ + + +W N + +
Sbjct: 327 H--TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNP 384
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIR-KLQDFEVK 1029
+E V +C ++ + + V + P + + Q V
Sbjct: 385 -NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI 443
Query: 1030 EKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
+ L+ S + W ++G+ Y + G + IR D+G Y+
Sbjct: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYT 500
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ + AE V V+ P I ++Q +G E + +L V W KD
Sbjct: 501 CVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
+ N ++ D L I+ D G Y+C E+ A LTV
Sbjct: 561 DEPLYIGNRMKKEDD----SLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATP 616
Query: 1199 TLRL 1202
T RL
Sbjct: 617 TNRL 620
Score = 60.1 bits (139), Expect = 9e-08
Identities = 146/705 (20%), Positives = 255/705 (36%), Gaps = 79/705 (11%)
Query: 828 ENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGE 886
E +PP + ++ V + I + NP PS W RN+ + ++ +
Sbjct: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95
Query: 887 NIELVI---TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT-FVKHLQKSYETEE 942
+ LVI + E G+Y+C A N G + R+ + V K + K +E
Sbjct: 96 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN-RIRLQVSKSPLWPKENLDPVVVQE 154
Query: 943 GKTVILECQTSHTVSTK---WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV-IK 998
G + L+C + + W + E D R + +G D+
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR--VSQGHNGDLYFSNVMLQDMQTDYS 212
Query: 999 C--------IVKDQETSTMLV-----VKETIPEFI----RKLQDFEVKEKDVAILEVEIN 1041
C ++ + T+ V V E P F+ ++ D+ + +
Sbjct: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
T D+ W + G + K K++ + L I N S D GEY C+ ++ + T
Sbjct: 273 VPTPDIAWYKKGGDLPSDKAKFE----NFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 328
Query: 1102 V---VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
+ V+ P + +N + G V+W +G +Q S +
Sbjct: 329 ISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNRE 387
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGN-------SKCTAILTVEEPSINFTLRLPEFILVPA 1210
+ D + Y C N + ++L V ++ +L IL
Sbjct: 388 VAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNR 447
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
P TL W+K D + + + +IRK +DQ YTCV
Sbjct: 448 TRLDCPFFGSPIPTL--RWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYTCV 502
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNS 1325
+ K+ ++++EV + P +I + +RG+ V L V + + W+ +
Sbjct: 503 ATNILGKAENQVRLEVKD-PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 561
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL-DKPSP- 1383
+ + K DS LTI V D G Y + +T+L D+ +P
Sbjct: 562 EPLYIGNRMKKEDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPT 617
Query: 1384 ----------PGKPNILEIDS---SSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWI 1428
P +P LE+ S+ + W P + NS I YVV+++E W
Sbjct: 618 NRLAALPKGRPDRPRDLELTDLAERSVRLTWI-PGDANNSPITDYVVQFEEDQFQPGVWH 676
Query: 1429 S-VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
K +++ L +Y+FR A+NEV S S +E Y+
Sbjct: 677 DHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYR 721
Score = 59.7 bits (138), Expect = 1e-07
Identities = 79/403 (19%), Positives = 153/403 (37%), Gaps = 24/403 (5%)
Query: 1287 PPKIVDYE-REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
PP I +++ + ++ + + + P P+ W NS+ K + S+ +S +L
Sbjct: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
Query: 1346 TIK-----KVENTDAGIYKLRLENNCGHA-DVEMNVTILDKPSPPGKPNILEI---DSSS 1396
I + E + G Y+ N G A + + + P P K N+ + + +
Sbjct: 100 VIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLWP-KENLDPVVVQEGAP 157
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQTSIQNLKTNSSYRFRA 1453
+ + + P + I + + I + +S + + + +Q+++T+ S R
Sbjct: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARF 217
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP---NEDIELTCIFGGVPQ 1510
+ + I + T + ++P+ P +++ D+ L CI GVP
Sbjct: 218 HFTHT--IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
Query: 1511 PKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ 1569
P + WY+ G L + KA +EN Y C+A N G + + V ++
Sbjct: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
Query: 1570 KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV 1629
P +E G++ + G P P V W NG L++ N +
Sbjct: 336 APYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP-NPNREVAGDT 392
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
I ++ + S + Y SN G + V D P + P
Sbjct: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 435
Score = 54.8 bits (126), Expect = 3e-06
Identities = 125/594 (21%), Positives = 226/594 (38%), Gaps = 64/594 (10%)
Query: 717 GEASLPIVLKIKTGEKEPPQVI-EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNK-- 773
G +P+ I+ +PP + + K IV +++++ + GNP P+ W +N++
Sbjct: 23 GAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF 82
Query: 774 PVKALPTKSDGDTHSITILK----PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
+ P S ++ + + EG Y A N G A ++ + + +
Sbjct: 83 NIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRI-----RLQVS 137
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRN-PVPSITWYRNN-EIISPSETITQNFDGEN 887
P + V+E + L P P I W ++ E I+ + ++Q G N
Sbjct: 138 KSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQ---GHN 194
Query: 888 IELVITNVDSEIDSGDYKCVA-----SNSAGKSSHGARV--TIDVEKVT----FVKHLQK 936
+L +NV + DY C A K+ +V T V + T + +
Sbjct: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTAS 254
Query: 937 SYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDV 994
S G ++LEC S T WY ++ D + E D
Sbjct: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKF--ENFNKALRITNVSEEDS 311
Query: 995 GVIKCIVKDQETS---TMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WE 1050
G C+ ++ S T+ V + P ++ + ++ + + L N V W
Sbjct: 312 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 371
Query: 1051 RDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----CTAEVTVVELP 1106
+GE ++ + E G + R+T + Y C +E A V+V+++P
Sbjct: 372 VNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
Query: 1107 PEIIT-RLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P +++ R Q +V N+ + +RWFK+G + ++K
Sbjct: 430 PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIK 489
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+ +D G Y+C +G ++ L V++P+ + R+PE + T L +
Sbjct: 490 M--IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIY--RMPEDQVARRGTTVQLECRV 545
Query: 1221 ---PDETLDVTWYKKKSVIEDTEKFTLISDVKKR--TLIIRKCTEDDQCEYTCV 1269
P L V+W K D E + + +KK +L I E DQ YTCV
Sbjct: 546 KHDPSLKLTVSWLK------DDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCV 593
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 261 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 316
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 317 LASNKMGSIRHTISVRVKA 335
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 449 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 505
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 506 ILGKAENQVRLEVKDP 521
Score = 38.7 bits (86), Expect = 0.23
Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS--VKNITKT 1436
D PS P + + + + +IN+ WD PE+ N +I Y ++Y + T+ V+N +
Sbjct: 823 DLPSAPRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGTKVGKQIVENFSPN 881
Query: 1437 QT--SIQNLKTNSSYRFRAYAVNEVDISDA 1464
QT ++Q S YRF A +V +A
Sbjct: 882 QTKFTVQRTDPVSRYRFTLSARTQVGSGEA 911
>AL391822-4|CAI14660.1| 1347|Homo sapiens neurofascin homolog
(chicken) protein.
Length = 1347
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 307
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 308 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 363
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 364 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 423
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 424 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 475
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 476 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 532
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 533 ARRGTTVQLECRVKHDPSLK 552
Score = 101 bits (242), Expect = 3e-20
Identities = 121/520 (23%), Positives = 205/520 (39%), Gaps = 38/520 (7%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXX---XXXXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 464 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPL-DDGGLELTKYAIEKHEP--DNNRWIKVAD---- 1718
P +++R T++ + + D L+LT ++ EP NR K D
Sbjct: 522 TRIYRMP--EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI 579
Query: 1719 ---VDRDVETY-CI--QKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXX 1772
+RD +Y C+ +L+++ + + + + L + P K D P
Sbjct: 580 FGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALP---KGRPDRP----R 632
Query: 1773 XXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK----QEGKKWKXXXXXXXXXARIQK 1828
+ SV +TW P + N SPI DY V+ + Q G + + +
Sbjct: 633 DLELTDLAERSVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLR 691
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
LS YQFR+ A NE+G+S P ++ P S P + + ++ + WT
Sbjct: 692 LSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGA-PPESNPGDVKGEGTRKNNMEITWTP 750
Query: 1889 PESNGG-SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
+ P YI++++ + + VTV GS + + EI R+ AEN G
Sbjct: 751 MNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEI--RVQAENDFG 808
Query: 1948 VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSW 1987
E +SV P +++R++ S + W
Sbjct: 809 KG--PEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQW 846
Score = 69.3 bits (162), Expect = 1e-10
Identities = 76/303 (25%), Positives = 123/303 (40%), Gaps = 31/303 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 392
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 393 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 445
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 446 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 505
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 506 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 557
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+++E + I E+ L I V +E D G Y CVAS + A +T+ +
Sbjct: 558 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTVLAD 612
Query: 927 KVT 929
+ T
Sbjct: 613 QAT 615
Score = 67.7 bits (158), Expect = 4e-10
Identities = 132/604 (21%), Positives = 220/604 (36%), Gaps = 57/604 (9%)
Query: 633 PPTFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMH 689
PPT +K+ K VD +IL+EC P P W I D +S+ S
Sbjct: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ + + EG Y A N+ G A S I L++ P + ++P ++V++
Sbjct: 100 VI--DFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQE 154
Query: 749 GESVILSAQ-VVGNPRPTITWCKNN-KPV---KALPTKSDGDTHSITILKPKKVKDEG-- 801
G + L G P P I W ++ +P+ K + +GD + ++ D
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCN 214
Query: 802 -----VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+T++ +N T V+T E V + L
Sbjct: 215 ARFHFTHTIQQKN----PFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 270
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+ P P I WY+ + + +NF N L ITNV SE DSG+Y C+ASN G
Sbjct: 271 SGVPTPDIAWYKKGGDLPSDKAKFENF---NKALRITNV-SEEDSGEYFCLASNKMGSIR 326
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHRE 974
H +++ V+ + K+ G+ L C+ + + +W N + +
Sbjct: 327 H--TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNP 384
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIR-KLQDFEVK 1029
+E V +C ++ + + V + P + + Q V
Sbjct: 385 -NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI 443
Query: 1030 EKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
+ L+ S + W ++G+ Y + G + IR D+G Y+
Sbjct: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYT 500
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ + AE V V+ P I ++Q +G E + +L V W KD
Sbjct: 501 CVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINF 1198
+ N ++ D L I+ D G Y+C E+ A LTV
Sbjct: 561 DEPLYIGNRMKKEDD----SLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATP 616
Query: 1199 TLRL 1202
T RL
Sbjct: 617 TNRL 620
Score = 62.9 bits (146), Expect = 1e-08
Identities = 117/589 (19%), Positives = 215/589 (36%), Gaps = 45/589 (7%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F G P P + W+++G+ Y Y C+A N G+
Sbjct: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509
Query: 1559 VETSCVVGIQQKPVITISNED--------IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG 1610
E + ++ I ED ++ + +V + + + + E ++ N
Sbjct: 510 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR 569
Query: 1611 NKLENDKE--YNITTKEKTSV--IRIKELKRSHSSKY-TIEASNTAGTSSVEVTLKVYDK 1665
K E+D + + +++ S + EL + + Y T+ A T+ + K +
Sbjct: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPK--GR 627
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WIKVADVDRDV 1723
P +P + + +++ SV + W P D +T Y ++ E W + V
Sbjct: 628 PDRPRD-LELTDLAERSVRLTWIPG-DANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV 685
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
+ + +L+ Y FRVIA N VG S +L SE +T+ P
Sbjct: 686 NS-AVLRLSPYVNYQFRVIAINEVGSSHPSLPSER--YRTSGAPPESNPGDVKGEGTRKN 742
Query: 1783 SVYITWFPSEKNGG-SPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRI 1839
++ ITW P P + Y V+ ++ + W + + + Y+ R+
Sbjct: 743 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV-VGQTPVYVPYEIRV 801
Query: 1840 YARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A N+ G P + I P + P V S +++L+W S+ +
Sbjct: 802 QAENDFGKG-P-EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD---TVQG 856
Query: 1900 YIIEFKTV--KGKSWTKIVTVGGSVHEHCIENIKEKDEI--IFRISAENTVGVSLPTESQ 1955
+ E++ + S K + V + + + + +F S V +
Sbjct: 857 QLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGD 916
Query: 1956 SVRLE-KHATVP-SPPTAPLEIRMVGSNI--VMTSWGTPEWDGGAPLLGYNI--AIRDVT 2009
R E K T P P+AP R+ N+ + W PE G ++GY + + T
Sbjct: 917 GPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGI-MIGYTLKYVAFNGT 975
Query: 2010 KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
K V N KF ++ Y + AR ++G E + + P
Sbjct: 976 KVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1024
Score = 60.1 bits (139), Expect = 9e-08
Identities = 146/705 (20%), Positives = 255/705 (36%), Gaps = 79/705 (11%)
Query: 828 ENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGE 886
E +PP + ++ V + I + NP PS W RN+ + ++ +
Sbjct: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95
Query: 887 NIELVI---TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT-FVKHLQKSYETEE 942
+ LVI + E G+Y+C A N G + R+ + V K + K +E
Sbjct: 96 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN-RIRLQVSKSPLWPKENLDPVVVQE 154
Query: 943 GKTVILECQTSHTVSTK---WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV-IK 998
G + L+C + + W + E D R + +G D+
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR--VSQGHNGDLYFSNVMLQDMQTDYS 212
Query: 999 C--------IVKDQETSTMLV-----VKETIPEFI----RKLQDFEVKEKDVAILEVEIN 1041
C ++ + T+ V V E P F+ ++ D+ + +
Sbjct: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
T D+ W + G + K K++ + L I N S D GEY C+ ++ + T
Sbjct: 273 VPTPDIAWYKKGGDLPSDKAKFE----NFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 328
Query: 1102 V---VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTID 1157
+ V+ P + +N + G V+W +G +Q S +
Sbjct: 329 ISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNRE 387
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEVGN-------SKCTAILTVEEPSINFTLRLPEFILVPA 1210
+ D + Y C N + ++L V ++ +L IL
Sbjct: 388 VAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNR 447
Query: 1211 NTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
P TL W+K D + + + +IRK +DQ YTCV
Sbjct: 448 TRLDCPFFGSPIPTL--RWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYTCV 502
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNS 1325
+ K+ ++++EV + P +I + +RG+ V L V + + W+ +
Sbjct: 503 ATNILGKAENQVRLEVKD-PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 561
Query: 1326 KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL-DKPSP- 1383
+ + K DS LTI V D G Y + +T+L D+ +P
Sbjct: 562 EPLYIGNRMKKEDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPT 617
Query: 1384 ----------PGKPNILEIDS---SSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWI 1428
P +P LE+ S+ + W P + NS I YVV+++E W
Sbjct: 618 NRLAALPKGRPDRPRDLELTDLAERSVRLTWI-PGDANNSPITDYVVQFEEDQFQPGVWH 676
Query: 1429 S-VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
K +++ L +Y+FR A+NEV S S +E Y+
Sbjct: 677 DHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYR 721
Score = 59.7 bits (138), Expect = 1e-07
Identities = 79/403 (19%), Positives = 153/403 (37%), Gaps = 24/403 (5%)
Query: 1287 PPKIVDYE-REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
PP I +++ + ++ + + + P P+ W NS+ K + S+ +S +L
Sbjct: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
Query: 1346 TIK-----KVENTDAGIYKLRLENNCGHA-DVEMNVTILDKPSPPGKPNILEI---DSSS 1396
I + E + G Y+ N G A + + + P P K N+ + + +
Sbjct: 100 VIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLWP-KENLDPVVVQEGAP 157
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQTSIQNLKTNSSYRFRA 1453
+ + + P + I + + I + +S + + + +Q+++T+ S R
Sbjct: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARF 217
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP---NEDIELTCIFGGVPQ 1510
+ + I + T + ++P+ P +++ D+ L CI GVP
Sbjct: 218 HFTHT--IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
Query: 1511 PKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ 1569
P + WY+ G L + KA +EN Y C+A N G + + V ++
Sbjct: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
Query: 1570 KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV 1629
P +E G++ + G P P V W NG L++ N +
Sbjct: 336 APYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP-NPNREVAGDT 392
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
I ++ + S + Y SN G + V D P + P
Sbjct: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 435
Score = 54.8 bits (126), Expect = 3e-06
Identities = 125/594 (21%), Positives = 226/594 (38%), Gaps = 64/594 (10%)
Query: 717 GEASLPIVLKIKTGEKEPPQVI-EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNK-- 773
G +P+ I+ +PP + + K IV +++++ + GNP P+ W +N++
Sbjct: 23 GAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF 82
Query: 774 PVKALPTKSDGDTHSITILK----PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
+ P S ++ + + EG Y A N G A ++ + + +
Sbjct: 83 NIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRI-----RLQVS 137
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRN-PVPSITWYRNN-EIISPSETITQNFDGEN 887
P + V+E + L P P I W ++ E I+ + ++Q G N
Sbjct: 138 KSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQ---GHN 194
Query: 888 IELVITNVDSEIDSGDYKCVA-----SNSAGKSSHGARV--TIDVEKVT----FVKHLQK 936
+L +NV + DY C A K+ +V T V + T + +
Sbjct: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTAS 254
Query: 937 SYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDV 994
S G ++LEC S T WY ++ D + E D
Sbjct: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKF--ENFNKALRITNVSEEDS 311
Query: 995 GVIKCIVKDQETS---TMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WE 1050
G C+ ++ S T+ V + P ++ + ++ + + L N V W
Sbjct: 312 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 371
Query: 1051 RDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----CTAEVTVVELP 1106
+GE ++ + E G + R+T + Y C +E A V+V+++P
Sbjct: 372 VNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
Query: 1107 PEIIT-RLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P +++ R Q +V N+ + +RWFK+G + ++K
Sbjct: 430 PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIK 489
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+ +D G Y+C +G ++ L V++P+ + R+PE + T L +
Sbjct: 490 M--IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIY--RMPEDQVARRGTTVQLECRV 545
Query: 1221 ---PDETLDVTWYKKKSVIEDTEKFTLISDVKKR--TLIIRKCTEDDQCEYTCV 1269
P L V+W K D E + + +KK +L I E DQ YTCV
Sbjct: 546 KHDPSLKLTVSWLK------DDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCV 593
Score = 52.4 bits (120), Expect = 2e-05
Identities = 68/267 (25%), Positives = 110/267 (41%), Gaps = 28/267 (10%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P +PR+ +++ RSV L W ++N SPIT+Y+++F+ + + W GSV+
Sbjct: 628 PDRPRDLELTDLAERSVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN 686
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTA-PLEIRMVGS-- 1980
+ + FR+ A N VG S P S+ E++ T +PP + P +++ G+
Sbjct: 687 S-AVLRLSPYVNYQFRVIAINEVGSSHP----SLPSERYRTSGAPPESNPGDVKGEGTRK 741
Query: 1981 NIVMTSWGTP--EWDGGAPLLGYNIA-IRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTY 2037
N + +W TP P L Y + R T+ W V V ++ + Y
Sbjct: 742 NNMEITW-TPMNATSAFGPNLRYIVKWRRRETREAW---NNVTVWGSRYVVGQTPVYVPY 797
Query: 2038 MIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLREH 2097
IR+ A N+ G + EP VI G D TEV W R +
Sbjct: 798 EIRVQAENDFG-----KGPEPESVIGYSGE--DYPRAAPTEVKVRVMNSTAISLQWNRVY 850
Query: 2098 N--MDADIRSYARGSLLRRDEYFFRIW 2122
+ + +R Y R R +W
Sbjct: 851 SDTVQGQLREY-RAYYWRESSLLKNLW 876
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 261 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 316
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 317 LASNKMGSIRHTISVRVKA 335
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 449 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 505
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 506 ILGKAENQVRLEVKDP 521
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/110 (25%), Positives = 43/110 (39%), Gaps = 4/110 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE- 1924
PS PR F V + ++ L+W PE G I Y +++ G K + S ++
Sbjct: 932 PSAPRRFRVRQPNLETINLEWDHPEHPNGIMI-GYTLKYVAFNGTKVGKQIVENFSPNQT 990
Query: 1925 -HCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHAT-VPSPPTAP 1972
++ F +SA VG +S AT +PPT P
Sbjct: 991 KFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAPPTLP 1040
Score = 37.1 bits (82), Expect = 0.69
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 5/88 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS--VKNITKTQT 1438
PS P + + + + +IN+ WD PE+ N +I Y ++Y + T+ V+N + QT
Sbjct: 932 PSAPRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGTKVGKQIVENFSPNQT 990
Query: 1439 --SIQNLKTNSSYRFRAYAVNEVDISDA 1464
++Q S YRF A +V +A
Sbjct: 991 KFTVQRTDPVSRYRFTLSARTQVGSGEA 1018
>AL391822-3|CAI14658.1| 1174|Homo sapiens neurofascin homolog
(chicken) protein.
Length = 1174
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 266 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 318
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 319 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 374
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 375 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 434
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 435 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 486
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 487 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 543
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 544 ARRGTTVQLECRVKHDPSLK 563
Score = 99.1 bits (236), Expect = 2e-19
Identities = 115/510 (22%), Positives = 200/510 (39%), Gaps = 33/510 (6%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXX---XXXXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 355 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 414
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 475 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 532
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPL-DDGGLELTKYAIEKHEP--DNNRWIKVADVDRD 1722
P +++R T++ + + D L+LT ++ EP NR + ++
Sbjct: 533 TRIYRMP--EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR------MKKE 584
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
++ I + E + + +A + + L + + D P +
Sbjct: 585 DDSLTIFGVAERDQGSYTCVASTEL--DQDLAKAYLTVLGRPDRP----RDLELTDLAER 638
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIK----QEGKKWKXXXXXXXXXARIQKLSINTTYQFR 1838
SV +TW P + N SPI DY V+ + Q G + + +LS YQFR
Sbjct: 639 SVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFR 697
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG-SPI 1897
+ A NE+G+S P ++ P S P + + ++ + WT + P
Sbjct: 698 VIAINEVGSSHPSLPSERYRTSGA-PPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPN 756
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
YI++++ + + VTV GS + + EI R+ AEN G E +SV
Sbjct: 757 LRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEI--RVQAENDFGKG--PEPESV 812
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSW 1987
P +++R++ S + W
Sbjct: 813 IGYSGEDYPRAAPTEVKVRVMNSTAISLQW 842
Score = 68.9 bits (161), Expect = 2e-10
Identities = 122/578 (21%), Positives = 207/578 (35%), Gaps = 38/578 (6%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F G P P + W+++G+ Y Y C+A N G+
Sbjct: 461 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 520
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE--VIWYKNGNKLEND 1616
E + ++ I ED Q + G + ++ P + V W K+ L
Sbjct: 521 AENQVRLEVKDPTRIYRMPED--QVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 578
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
N KE S+ +R S YT AS + L V +P +P + +
Sbjct: 579 ---NRMKKEDDSLTIFGVAERDQGS-YTCVASTELDQDLAKAYLTVLGRPDRPRD-LELT 633
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WIKVADVDRDVETYCIQKLNEN 1734
+++ SV + W P D +T Y ++ E W + V + + +L+
Sbjct: 634 DLAERSVRLTWIPG-DANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNS-AVLRLSPY 691
Query: 1735 CEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEK 1793
Y FRVIA N VG S +L SE +T+ P ++ ITW P
Sbjct: 692 VNYQFRVIAINEVGSSHPSLPSER--YRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNA 749
Query: 1794 NGG-SPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
P + Y V+ ++ + W + + + Y+ R+ A N+ G P
Sbjct: 750 TSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV-VGQTPVYVPYEIRVQAENDFGKG-P 807
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTV--K 1908
+ I P + P V S +++L+W S+ + + E++ +
Sbjct: 808 -EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD---TVQGQLREYRAYYWR 863
Query: 1909 GKSWTKIVTVGGSVHEHCIENIKEKDEI--IFRISAENTVGVSLPTESQSVRLE-KHATV 1965
S K + V + + + + +F S V + R E K T
Sbjct: 864 ESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTT 923
Query: 1966 P-SPPTAPLEIRMVGSNI--VMTSWGTPEWDGGAPLLGYNI--AIRDVTKTMWMEVGKVD 2020
P P+AP R+ N+ + W PE G ++GY + + TK V
Sbjct: 924 PEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGI-MIGYTLKYVAFNGTKVGKQIVENFS 982
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
N KF ++ Y + AR ++G E + + P
Sbjct: 983 PNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1020
Score = 67.7 bits (158), Expect = 4e-10
Identities = 75/297 (25%), Positives = 120/297 (40%), Gaps = 31/297 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 348 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 403
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 404 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 456
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 457 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 516
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 517 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 568
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+++E + I E+ L I V +E D G Y CVAS + A +T+
Sbjct: 569 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTV 620
Score = 65.3 bits (152), Expect = 2e-09
Identities = 98/448 (21%), Positives = 169/448 (37%), Gaps = 35/448 (7%)
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
T D+ W + G + K K++ + L I N S D GEY C+ ++ + T+
Sbjct: 286 TPDIAWYKKGGDLPSDKAKFE----NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 341
Query: 1103 --VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGK 1159
V+ P + +N + G V+W +G +Q S +
Sbjct: 342 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 400
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGN-------SKCTAILTVEEPSINFTLRLPEFILVPANT 1212
+ D + Y C N + ++L V ++ +L IL
Sbjct: 401 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 460
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
P TL W+K D + + + +IRK +DQ YTCV
Sbjct: 461 LDCPFFGSPIPTL--RWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYTCVAT 515
Query: 1272 D--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKI 1327
+ K+ ++++EV + P +I + +RG+ V L V + + W+ + +
Sbjct: 516 NILGKAENQVRLEVKD-PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 574
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKP 1387
+ K DS LTI V D G Y + +T+L +P P
Sbjct: 575 LYIGNRMKKEDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDL 630
Query: 1388 NILEIDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWIS-VKNITKTQTSIQNLK 1444
+ ++ S+ + W P + NS I YVV+++E W K +++ L
Sbjct: 631 ELTDLAERSVRLTWI-PGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLS 689
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYYK 1472
+Y+FR A+NEV S S +E Y+
Sbjct: 690 PYVNYQFRVIAINEVGSSHPSLPSERYR 717
Score = 58.8 bits (136), Expect = 2e-07
Identities = 44/176 (25%), Positives = 67/176 (38%), Gaps = 4/176 (2%)
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDH 1556
D+ L CI GVP P + WY+ G L + KA +EN Y C+A N
Sbjct: 274 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKM 333
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
G + + V ++ P +E G++ + G P P V W NG L++
Sbjct: 334 GSIRHTISVRVKAAPYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSA 391
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
N + I ++ + S + Y SN G + V D P + P
Sbjct: 392 PP-NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 446
Score = 56.8 bits (131), Expect = 8e-07
Identities = 128/606 (21%), Positives = 227/606 (37%), Gaps = 66/606 (10%)
Query: 633 PPTFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMH 689
PPT +K+ K VD +IL+EC P P W I D +S+ S
Sbjct: 34 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 93
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ + + EG Y A N+ G A S I L++ P + ++P ++V++
Sbjct: 94 VI--DFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQE 148
Query: 749 GESVILSAQ-VVGNPRPTITWCKNN-KPV---KALPTKSDGDTH-SITILKPKK------ 796
G + L G P P I W ++ +P+ K + +GD + S +L+ +
Sbjct: 149 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCN 208
Query: 797 --------VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
++ + +TLK + ++S + + + + T +
Sbjct: 209 ARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQM 268
Query: 849 TIK---LVARVTRNPVPS--ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
++ L+ + VP+ I WY+ + + +NF N L ITNV SE DSG+
Sbjct: 269 VLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENF---NKALRITNV-SEEDSGE 324
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWY 961
Y C+ASN G H +++ V+ + K+ G+ L C+ + + +W
Sbjct: 325 YFCLASNKMGSIRH--TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 382
Query: 962 HNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIP 1017
N + + +E V +C ++ + + V + P
Sbjct: 383 VNGEPLQSAPPNP-NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 441
Query: 1018 EFIR-KLQDFEVKEKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
+ + Q V + L+ S + W ++G+ Y + G +
Sbjct: 442 RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 501
Query: 1076 IRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTK 1132
IR D+G Y+C+ + AE V V+ P I ++Q +G E +
Sbjct: 502 IRK---EDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKH 558
Query: 1133 GDAL---VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKC 1185
+L V W KD + N ++ D L I+ D G Y+C E+
Sbjct: 559 DPSLKLTVSWLKDDEPLYIGNRMKKEDD----SLTIFGVAERDQGSYTCVASTELDQDLA 614
Query: 1186 TAILTV 1191
A LTV
Sbjct: 615 KAYLTV 620
Score = 52.4 bits (120), Expect = 2e-05
Identities = 68/267 (25%), Positives = 110/267 (41%), Gaps = 28/267 (10%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P +PR+ +++ RSV L W ++N SPIT+Y+++F+ + + W GSV+
Sbjct: 624 PDRPRDLELTDLAERSVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN 682
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTA-PLEIRMVGS-- 1980
+ + FR+ A N VG S P S+ E++ T +PP + P +++ G+
Sbjct: 683 S-AVLRLSPYVNYQFRVIAINEVGSSHP----SLPSERYRTSGAPPESNPGDVKGEGTRK 737
Query: 1981 NIVMTSWGTP--EWDGGAPLLGYNIA-IRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTY 2037
N + +W TP P L Y + R T+ W V V ++ + Y
Sbjct: 738 NNMEITW-TPMNATSAFGPNLRYIVKWRRRETREAW---NNVTVWGSRYVVGQTPVYVPY 793
Query: 2038 MIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLREH 2097
IR+ A N+ G + EP VI G D TEV W R +
Sbjct: 794 EIRVQAENDFG-----KGPEPESVIGYSGE--DYPRAAPTEVKVRVMNSTAISLQWNRVY 846
Query: 2098 N--MDADIRSYARGSLLRRDEYFFRIW 2122
+ + +R Y R R +W
Sbjct: 847 SDTVQGQLREY-RAYYWRESSLLKNLW 872
Score = 43.6 bits (98), Expect = 0.008
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + G+P P++ WYK G L +DK + +RI + S +Y
Sbjct: 272 GMDLLLECIASGVPTPDIAWYKKGGDLPSDK---AKFENFNKALRITNVSEEDSGEYFCL 328
Query: 1647 ASNTAGTSSVEVTLKVYDKP 1666
ASN G+ ++++V P
Sbjct: 329 ASNKMGSIRHTISVRVKAAP 348
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 272 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 327
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 328 LASNKMGSIRHTISVRVKA 346
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 460 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 516
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 517 ILGKAENQVRLEVKDP 532
Score = 37.1 bits (82), Expect = 0.69
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 5/88 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS--VKNITKTQT 1438
PS P + + + + +IN+ WD PE+ N +I Y ++Y + T+ V+N + QT
Sbjct: 928 PSAPRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGTKVGKQIVENFSPNQT 986
Query: 1439 --SIQNLKTNSSYRFRAYAVNEVDISDA 1464
++Q S YRF A +V +A
Sbjct: 987 KFTVQRTDPVSRYRFTLSARTQVGSGEA 1014
Score = 34.7 bits (76), Expect = 3.7
Identities = 30/133 (22%), Positives = 54/133 (40%), Gaps = 5/133 (3%)
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
+E P + P + ++ V + I + NP PS W RN+ + ++
Sbjct: 25 IEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRV 84
Query: 882 NFDGENIELVI---TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK-VTFVKHLQKS 937
+ + LVI + E G+Y+C A N G ++ R+ + V K + K
Sbjct: 85 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDP 143
Query: 938 YETEEGKTVILEC 950
+EG + L+C
Sbjct: 144 VVVQEGAPLTLQC 156
>AL391822-2|CAI14657.1| 619|Homo sapiens neurofascin homolog
(chicken) protein.
Length = 619
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 307
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 308 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 363
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 364 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 423
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 424 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 475
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 476 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 532
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 533 ARRGTTVQLECRVKHDPSLK 552
Score = 67.7 bits (158), Expect = 4e-10
Identities = 75/297 (25%), Positives = 120/297 (40%), Gaps = 31/297 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 392
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 393 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 445
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 446 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 505
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 506 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 557
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+++E + I E+ L I V +E D G Y CVAS + A +T+
Sbjct: 558 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTV 609
Score = 67.3 bits (157), Expect = 6e-10
Identities = 129/593 (21%), Positives = 217/593 (36%), Gaps = 57/593 (9%)
Query: 633 PPTFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMH 689
PPT +K+ K VD +IL+EC P P W I D +S+ S
Sbjct: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ + + EG Y A N+ G A S I L++ P + ++P ++V++
Sbjct: 100 VI--DFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQE 154
Query: 749 GESVILSAQ-VVGNPRPTITWCKNN-KPV---KALPTKSDGDTHSITILKPKKVKDEG-- 801
G + L G P P I W ++ +P+ K + +GD + ++ D
Sbjct: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCN 214
Query: 802 -----VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+T++ +N T V+T E V + L
Sbjct: 215 ARFHFTHTIQQKN----PFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 270
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+ P P I WY+ + + +NF N L ITNV SE DSG+Y C+ASN G
Sbjct: 271 SGVPTPDIAWYKKGGDLPSDKAKFENF---NKALRITNV-SEEDSGEYFCLASNKMGSIR 326
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHRE 974
H +++ V+ + K+ G+ L C+ + + +W N + +
Sbjct: 327 H--TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNP 384
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIR-KLQDFEVK 1029
+E V +C ++ + + V + P + + Q V
Sbjct: 385 -NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI 443
Query: 1030 EKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
+ L+ S + W ++G+ Y + G + IR D+G Y+
Sbjct: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYT 500
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ + AE V V+ P I ++Q +G E + +L V W KD
Sbjct: 501 CVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
Query: 1143 GSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTV 1191
+ N ++ D L I+ D G Y+C E+ A LTV
Sbjct: 561 DEPLYIGNRMKKEDD----SLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
Score = 62.1 bits (144), Expect = 2e-08
Identities = 54/224 (24%), Positives = 91/224 (40%), Gaps = 8/224 (3%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXX---XXXXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 464 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPL-DDGGLELTKYAIEKHEP 1708
P +++R T++ + + D L+LT ++ EP
Sbjct: 522 TRIYRMP--EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 563
Score = 59.7 bits (138), Expect = 1e-07
Identities = 79/403 (19%), Positives = 153/403 (37%), Gaps = 24/403 (5%)
Query: 1287 PPKIVDYE-REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASL 1345
PP I +++ + ++ + + + P P+ W NS+ K + S+ +S +L
Sbjct: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
Query: 1346 TIK-----KVENTDAGIYKLRLENNCGHA-DVEMNVTILDKPSPPGKPNILEI---DSSS 1396
I + E + G Y+ N G A + + + P P K N+ + + +
Sbjct: 100 VIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLWP-KENLDPVVVQEGAP 157
Query: 1397 INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQTSIQNLKTNSSYRFRA 1453
+ + + P + I + + I + +S + + + +Q+++T+ S R
Sbjct: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARF 217
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP---NEDIELTCIFGGVPQ 1510
+ + I + T + ++P+ P +++ D+ L CI GVP
Sbjct: 218 HFTHT--IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
Query: 1511 PKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ 1569
P + WY+ G L + KA +EN Y C+A N G + + V ++
Sbjct: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
Query: 1570 KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV 1629
P +E G++ + G P P V W NG L++ N +
Sbjct: 336 APYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP-NPNREVAGDT 392
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
I ++ + S + Y SN G + V D P + P
Sbjct: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 435
Score = 54.8 bits (126), Expect = 3e-06
Identities = 125/594 (21%), Positives = 226/594 (38%), Gaps = 64/594 (10%)
Query: 717 GEASLPIVLKIKTGEKEPPQVI-EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNK-- 773
G +P+ I+ +PP + + K IV +++++ + GNP P+ W +N++
Sbjct: 23 GAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF 82
Query: 774 PVKALPTKSDGDTHSITILK----PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
+ P S ++ + + EG Y A N G A ++ + + +
Sbjct: 83 NIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRI-----RLQVS 137
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRN-PVPSITWYRNN-EIISPSETITQNFDGEN 887
P + V+E + L P P I W ++ E I+ + ++Q G N
Sbjct: 138 KSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQ---GHN 194
Query: 888 IELVITNVDSEIDSGDYKCVA-----SNSAGKSSHGARV--TIDVEKVT----FVKHLQK 936
+L +NV + DY C A K+ +V T V + T + +
Sbjct: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTAS 254
Query: 937 SYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDV 994
S G ++LEC S T WY ++ D + E D
Sbjct: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKF--ENFNKALRITNVSEEDS 311
Query: 995 GVIKCIVKDQETS---TMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WE 1050
G C+ ++ S T+ V + P ++ + ++ + + L N V W
Sbjct: 312 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 371
Query: 1051 RDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----CTAEVTVVELP 1106
+GE ++ + E G + R+T + Y C +E A V+V+++P
Sbjct: 372 VNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
Query: 1107 PEIIT-RLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
P +++ R Q +V N+ + +RWFK+G + ++K
Sbjct: 430 PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIK 489
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+ +D G Y+C +G ++ L V++P+ + R+PE + T L +
Sbjct: 490 M--IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIY--RMPEDQVARRGTTVQLECRV 545
Query: 1221 ---PDETLDVTWYKKKSVIEDTEKFTLISDVKKR--TLIIRKCTEDDQCEYTCV 1269
P L V+W K D E + + +KK +L I E DQ YTCV
Sbjct: 546 KHDPSLKLTVSWLK------DDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCV 593
Score = 51.6 bits (118), Expect = 3e-05
Identities = 36/160 (22%), Positives = 70/160 (43%), Gaps = 7/160 (4%)
Query: 1224 TLDVTWYKKKSVI-EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
T D+ WYKK + D KF + + L I +E+D EY C+ + + + +
Sbjct: 275 TPDIAWYKKGGDLPSDKAKFENFN----KALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
Query: 1283 V-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
V V+ P +D + + G D L+ P+P +W+VN + ++ P+ +
Sbjct: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAP-PNPNREVA 389
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
++ + + + +Y+ N G+ V++LD P
Sbjct: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 261 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 316
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 317 LASNKMGSIRHTISVRVKA 335
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 449 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 505
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 506 ILGKAENQVRLEVKDP 521
Score = 33.9 bits (74), Expect = 6.4
Identities = 46/249 (18%), Positives = 90/249 (36%), Gaps = 12/249 (4%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN--SKCTAILTVEEP 1194
+ W+K G ++ + + + L+I + +D+GEY C N ++V
Sbjct: 278 IAWYKKGGDLPSD---KAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334
Query: 1195 SINFTLRLPEFILVPANTDAYLTVEI-PDETLDVTWYKKKSVIEDTEKFTLISDVKKRTL 1253
+ + L P+ +++ D L + V W ++ +V T+
Sbjct: 335 AAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP-NPNREVAGDTI 393
Query: 1254 IIRKCTEDDQCEYTCVLLDAKS--TTKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLLVD 1310
I R + Y C + V V++ PP+++ + R+ + L
Sbjct: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCP 453
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD 1370
+ P P W N + + + SL IK + D GIY N G A+
Sbjct: 454 FFGSPIPTLRWFKNGQGSNLDGGNYHVYE--NGSLEIKMIRKEDQGIYTCVATNILGKAE 511
Query: 1371 VEMNVTILD 1379
++ + + D
Sbjct: 512 NQVRLEVKD 520
>AB177861-1|BAD66839.1| 836|Homo sapiens KIAA0756 splice variant 1
protein.
Length = 836
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 63 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 115
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 116 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 171
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 172 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 231
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 232 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 283
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 284 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 340
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 341 ARRGTTVQLECRVKHDPSLK 360
Score = 99.1 bits (236), Expect = 2e-19
Identities = 115/510 (22%), Positives = 200/510 (39%), Gaps = 33/510 (6%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXX---XXXXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 152 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 211
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 212 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 271
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 272 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 329
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPL-DDGGLELTKYAIEKHEP--DNNRWIKVADVDRD 1722
P +++R T++ + + D L+LT ++ EP NR + ++
Sbjct: 330 TRIYRMP--EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR------MKKE 381
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
++ I + E + + +A + + L + + D P +
Sbjct: 382 DDSLTIFGVAERDQGSYTCVASTEL--DQDLAKAYLTVLGRPDRP----RDLELTDLAER 435
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIK----QEGKKWKXXXXXXXXXARIQKLSINTTYQFR 1838
SV +TW P + N SPI DY V+ + Q G + + +LS YQFR
Sbjct: 436 SVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFR 494
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG-SPI 1897
+ A NE+G+S P ++ P S P + + ++ + WT + P
Sbjct: 495 VIAINEVGSSHPSLPSERYRTSGA-PPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPN 553
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
YI++++ + + VTV GS + + EI R+ AEN G E +SV
Sbjct: 554 LRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEI--RVQAENDFGKG--PEPESV 609
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSW 1987
P +++R++ S + W
Sbjct: 610 IGYSGEDYPRAAPTEVKVRVMNSTAISLQW 639
Score = 71.3 bits (167), Expect = 3e-11
Identities = 127/594 (21%), Positives = 212/594 (35%), Gaps = 40/594 (6%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F G P P + W+++G+ Y Y C+A N G+
Sbjct: 258 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 317
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE--VIWYKNGNKLEND 1616
E + ++ I ED Q + G + ++ P + V W K+ L
Sbjct: 318 AENQVRLEVKDPTRIYRMPED--QVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 375
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
N KE S+ +R S YT AS + L V +P +P + +
Sbjct: 376 ---NRMKKEDDSLTIFGVAERDQGS-YTCVASTELDQDLAKAYLTVLGRPDRPRD-LELT 430
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WIKVADVDRDVETYCIQKLNEN 1734
+++ SV + W P D +T Y ++ E W + V + + +L+
Sbjct: 431 DLAERSVRLTWIPG-DANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNS-AVLRLSPY 488
Query: 1735 CEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEK 1793
Y FRVIA N VG S +L SE +T+ P ++ ITW P
Sbjct: 489 VNYQFRVIAINEVGSSHPSLPSER--YRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNA 546
Query: 1794 NGG-SPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
P + Y V+ ++ + W + + + Y+ R+ A N+ G P
Sbjct: 547 TSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV-VGQTPVYVPYEIRVQAENDFGKG-P 604
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTV--K 1908
+ I P + P V S +++L+W S+ + + E++ +
Sbjct: 605 -EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD---TVQGQLREYRAYYWR 660
Query: 1909 GKSWTKIVTVGGSVHEHCIENIKEKDEI--IFRISAENTVGVSLPTESQSVRLE-KHATV 1965
S K + V + + + + +F S V + R E K T
Sbjct: 661 ESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTT 720
Query: 1966 P-SPPTAPLEIRMVGSNI--VMTSWGTPEWDGGAPLLGYNI--AIRDVTKTMWMEVGKVD 2020
P P+AP R+ N+ + W PE G ++GY + + TK V
Sbjct: 721 PEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGI-MIGYTLKYVAFNGTKVGKQIVENFS 779
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPG 2074
N KF ++ Y + AR ++G E + + P P EG PG
Sbjct: 780 PNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP--APPNEGRCMAAAPG 831
Score = 67.7 bits (158), Expect = 4e-10
Identities = 75/297 (25%), Positives = 120/297 (40%), Gaps = 31/297 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 145 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 200
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 201 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 253
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 254 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 313
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 314 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 365
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+++E + I E+ L I V +E D G Y CVAS + A +T+
Sbjct: 366 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTV 417
Score = 65.3 bits (152), Expect = 2e-09
Identities = 98/448 (21%), Positives = 169/448 (37%), Gaps = 35/448 (7%)
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
T D+ W + G + K K++ + L I N S D GEY C+ ++ + T+
Sbjct: 83 TPDIAWYKKGGDLPSDKAKFE----NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 138
Query: 1103 --VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGK 1159
V+ P + +N + G V+W +G +Q S +
Sbjct: 139 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 197
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGN-------SKCTAILTVEEPSINFTLRLPEFILVPANT 1212
+ D + Y C N + ++L V ++ +L IL
Sbjct: 198 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 257
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
P TL W+K D + + + +IRK +DQ YTCV
Sbjct: 258 LDCPFFGSPIPTL--RWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYTCVAT 312
Query: 1272 D--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKI 1327
+ K+ ++++EV + P +I + +RG+ V L V + + W+ + +
Sbjct: 313 NILGKAENQVRLEVKD-PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 371
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKP 1387
+ K DS LTI V D G Y + +T+L +P P
Sbjct: 372 LYIGNRMKKEDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDL 427
Query: 1388 NILEIDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWIS-VKNITKTQTSIQNLK 1444
+ ++ S+ + W P + NS I YVV+++E W K +++ L
Sbjct: 428 ELTDLAERSVRLTWI-PGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLS 486
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYYK 1472
+Y+FR A+NEV S S +E Y+
Sbjct: 487 PYVNYQFRVIAINEVGSSHPSLPSERYR 514
Score = 58.8 bits (136), Expect = 2e-07
Identities = 44/176 (25%), Positives = 67/176 (38%), Gaps = 4/176 (2%)
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDH 1556
D+ L CI GVP P + WY+ G L + KA +EN Y C+A N
Sbjct: 71 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKM 130
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
G + + V ++ P +E G++ + G P P V W NG L++
Sbjct: 131 GSIRHTISVRVKAAPYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSA 188
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
N + I ++ + S + Y SN G + V D P + P
Sbjct: 189 PP-NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 243
Score = 52.4 bits (120), Expect = 2e-05
Identities = 68/267 (25%), Positives = 110/267 (41%), Gaps = 28/267 (10%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P +PR+ +++ RSV L W ++N SPIT+Y+++F+ + + W GSV+
Sbjct: 421 PDRPRDLELTDLAERSVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN 479
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTA-PLEIRMVGS-- 1980
+ + FR+ A N VG S P S+ E++ T +PP + P +++ G+
Sbjct: 480 S-AVLRLSPYVNYQFRVIAINEVGSSHP----SLPSERYRTSGAPPESNPGDVKGEGTRK 534
Query: 1981 NIVMTSWGTP--EWDGGAPLLGYNIA-IRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTY 2037
N + +W TP P L Y + R T+ W V V ++ + Y
Sbjct: 535 NNMEITW-TPMNATSAFGPNLRYIVKWRRRETREAW---NNVTVWGSRYVVGQTPVYVPY 590
Query: 2038 MIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLREH 2097
IR+ A N+ G + EP VI G D TEV W R +
Sbjct: 591 EIRVQAENDFG-----KGPEPESVIGYSGE--DYPRAAPTEVKVRVMNSTAISLQWNRVY 643
Query: 2098 N--MDADIRSYARGSLLRRDEYFFRIW 2122
+ + +R Y R R +W
Sbjct: 644 SDTVQGQLREY-RAYYWRESSLLKNLW 669
Score = 43.6 bits (98), Expect = 0.008
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + G+P P++ WYK G L +DK + +RI + S +Y
Sbjct: 69 GMDLLLECIASGVPTPDIAWYKKGGDLPSDK---AKFENFNKALRITNVSEEDSGEYFCL 125
Query: 1647 ASNTAGTSSVEVTLKVYDKP 1666
ASN G+ ++++V P
Sbjct: 126 ASNKMGSIRHTISVRVKAAP 145
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 69 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 124
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 125 LASNKMGSIRHTISVRVKA 143
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 257 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 313
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 314 ILGKAENQVRLEVKDP 329
Score = 37.1 bits (82), Expect = 0.69
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 5/88 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS--VKNITKTQT 1438
PS P + + + + +IN+ WD PE+ N +I Y ++Y + T+ V+N + QT
Sbjct: 725 PSAPRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGTKVGKQIVENFSPNQT 783
Query: 1439 --SIQNLKTNSSYRFRAYAVNEVDISDA 1464
++Q S YRF A +V +A
Sbjct: 784 KFTVQRTDPVSRYRFTLSARTQVGSGEA 811
>AB018299-1|BAA34476.3| 1222|Homo sapiens KIAA0756 protein protein.
Length = 1222
Score = 126 bits (303), Expect = 1e-27
Identities = 90/320 (28%), Positives = 149/320 (46%), Gaps = 24/320 (7%)
Query: 642 AQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVK 701
+Q V G D+LLEC +P PDIAW KG ++ D+ + + L+ITNV
Sbjct: 319 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK-------AKFENFNKALRITNVS 371
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G Y +A N+ G I +++K P ++ K++I+ GE L + GN
Sbjct: 372 EEDSGEYFCLASNKMGSIRHTISVRVKAA----PYWLDEPKNLILAPGEDGRLVCRANGN 427
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITIL-KPKKVKDEGVYTLKAENSEGIAETSAVI 820
P+PT+ W N +P+++ P + + TI+ + ++ VY N G +A +
Sbjct: 428 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 487
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT 880
+V + P + R Q I V +L +P+P++ W++N + S
Sbjct: 488 SVLD-----VPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ---GSNLDG 539
Query: 881 QNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
N+ EN L I + E D G Y CVA+N GK+ + +V ++V+ T + + +
Sbjct: 540 GNYHVYENGSLEIKMIRKE-DQGIYTCVATNILGKAEN--QVRLEVKDPTRIYRMPEDQV 596
Query: 940 TEEGKTVILECQTSHTVSTK 959
G TV LEC+ H S K
Sbjct: 597 ARRGTTVQLECRVKHDPSLK 616
Score = 99.1 bits (236), Expect = 2e-19
Identities = 115/510 (22%), Positives = 200/510 (39%), Gaps = 33/510 (6%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXX---XXXXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 408 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 467
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 468 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 527
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 528 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 585
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPL-DDGGLELTKYAIEKHEP--DNNRWIKVADVDRD 1722
P +++R T++ + + D L+LT ++ EP NR + ++
Sbjct: 586 TRIYRMP--EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR------MKKE 637
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
++ I + E + + +A + + L + + D P +
Sbjct: 638 DDSLTIFGVAERDQGSYTCVASTEL--DQDLAKAYLTVLGRPDRP----RDLELTDLAER 691
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIK----QEGKKWKXXXXXXXXXARIQKLSINTTYQFR 1838
SV +TW P + N SPI DY V+ + Q G + + +LS YQFR
Sbjct: 692 SVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFR 750
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG-SPI 1897
+ A NE+G+S P ++ P S P + + ++ + WT + P
Sbjct: 751 VIAINEVGSSHPSLPSERYRTSGA-PPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPN 809
Query: 1898 TNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSV 1957
YI++++ + + VTV GS + + EI R+ AEN G E +SV
Sbjct: 810 LRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEI--RVQAENDFGKG--PEPESV 865
Query: 1958 RLEKHATVPSPPTAPLEIRMVGSNIVMTSW 1987
P +++R++ S + W
Sbjct: 866 IGYSGEDYPRAAPTEVKVRVMNSTAISLQW 895
Score = 68.9 bits (161), Expect = 2e-10
Identities = 122/578 (21%), Positives = 207/578 (35%), Gaps = 38/578 (6%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F G P P + W+++G+ Y Y C+A N G+
Sbjct: 514 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 573
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE--VIWYKNGNKLEND 1616
E + ++ I ED Q + G + ++ P + V W K+ L
Sbjct: 574 AENQVRLEVKDPTRIYRMPED--QVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 631
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
N KE S+ +R S YT AS + L V +P +P + +
Sbjct: 632 ---NRMKKEDDSLTIFGVAERDQGS-YTCVASTELDQDLAKAYLTVLGRPDRPRD-LELT 686
Query: 1677 EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR--WIKVADVDRDVETYCIQKLNEN 1734
+++ SV + W P D +T Y ++ E W + V + + +L+
Sbjct: 687 DLAERSVRLTWIPG-DANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNS-AVLRLSPY 744
Query: 1735 CEYMFRVIAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEK 1793
Y FRVIA N VG S +L SE +T+ P ++ ITW P
Sbjct: 745 VNYQFRVIAINEVGSSHPSLPSER--YRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNA 802
Query: 1794 NGG-SPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
P + Y V+ ++ + W + + + Y+ R+ A N+ G P
Sbjct: 803 TSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV-VGQTPVYVPYEIRVQAENDFGKG-P 860
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTV--K 1908
+ I P + P V S +++L+W S+ + + E++ +
Sbjct: 861 -EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD---TVQGQLREYRAYYWR 916
Query: 1909 GKSWTKIVTVGGSVHEHCIENIKEKDEI--IFRISAENTVGVSLPTESQSVRLE-KHATV 1965
S K + V + + + + +F S V + R E K T
Sbjct: 917 ESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTT 976
Query: 1966 P-SPPTAPLEIRMVGSNI--VMTSWGTPEWDGGAPLLGYNI--AIRDVTKTMWMEVGKVD 2020
P P+AP R+ N+ + W PE G ++GY + + TK V
Sbjct: 977 PEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGI-MIGYTLKYVAFNGTKVGKQIVENFS 1035
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
N KF ++ Y + AR ++G E + + P
Sbjct: 1036 PNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1073
Score = 67.7 bits (158), Expect = 4e-10
Identities = 75/297 (25%), Positives = 120/297 (40%), Gaps = 31/297 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 401 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 456
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 457 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 509
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 510 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 569
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 570 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 621
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+++E + I E+ L I V +E D G Y CVAS + A +T+
Sbjct: 622 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTV 673
Score = 65.3 bits (152), Expect = 2e-09
Identities = 98/448 (21%), Positives = 169/448 (37%), Gaps = 35/448 (7%)
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV- 1102
T D+ W + G + K K++ + L I N S D GEY C+ ++ + T+
Sbjct: 339 TPDIAWYKKGGDLPSDKAKFE----NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 394
Query: 1103 --VELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGK 1159
V+ P + +N + G V+W +G +Q S +
Sbjct: 395 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 453
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGN-------SKCTAILTVEEPSINFTLRLPEFILVPANT 1212
+ D + Y C N + ++L V ++ +L IL
Sbjct: 454 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 513
Query: 1213 DAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
P TL W+K D + + + +IRK +DQ YTCV
Sbjct: 514 LDCPFFGSPIPTL--RWFKNGQGSNLDGGNYHVYENGSLEIKMIRK---EDQGIYTCVAT 568
Query: 1272 D--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKI 1327
+ K+ ++++EV + P +I + +RG+ V L V + + W+ + +
Sbjct: 569 NILGKAENQVRLEVKD-PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 627
Query: 1328 IKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKP 1387
+ K DS LTI V D G Y + +T+L +P P
Sbjct: 628 LYIGNRMKKEDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDL 683
Query: 1388 NILEIDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWIS-VKNITKTQTSIQNLK 1444
+ ++ S+ + W P + NS I YVV+++E W K +++ L
Sbjct: 684 ELTDLAERSVRLTWI-PGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLS 742
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYYK 1472
+Y+FR A+NEV S S +E Y+
Sbjct: 743 PYVNYQFRVIAINEVGSSHPSLPSERYR 770
Score = 58.8 bits (136), Expect = 2e-07
Identities = 44/176 (25%), Positives = 67/176 (38%), Gaps = 4/176 (2%)
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDH 1556
D+ L CI GVP P + WY+ G L + KA +EN Y C+A N
Sbjct: 327 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKM 386
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
G + + V ++ P +E G++ + G P P V W NG L++
Sbjct: 387 GSIRHTISVRVKAAPYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSA 444
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
N + I ++ + S + Y SN G + V D P + P
Sbjct: 445 PP-NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 499
Score = 56.8 bits (131), Expect = 8e-07
Identities = 128/606 (21%), Positives = 227/606 (37%), Gaps = 66/606 (10%)
Query: 633 PPTFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMH 689
PPT +K+ K VD +IL+EC P P W I D +S+ S
Sbjct: 87 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 146
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
+ + + EG Y A N+ G A S I L++ P + ++P ++V++
Sbjct: 147 VI--DFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQE 201
Query: 749 GESVILSAQ-VVGNPRPTITWCKNN-KPV---KALPTKSDGDTH-SITILKPKK------ 796
G + L G P P I W ++ +P+ K + +GD + S +L+ +
Sbjct: 202 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCN 261
Query: 797 --------VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
++ + +TLK + ++S + + + + T +
Sbjct: 262 ARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQM 321
Query: 849 TIK---LVARVTRNPVPS--ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
++ L+ + VP+ I WY+ + + +NF N L ITNV SE DSG+
Sbjct: 322 VLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENF---NKALRITNV-SEEDSGE 377
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWY 961
Y C+ASN G H +++ V+ + K+ G+ L C+ + + +W
Sbjct: 378 YFCLASNKMGSIRH--TISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 435
Query: 962 HNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIP 1017
N + + +E V +C ++ + + V + P
Sbjct: 436 VNGEPLQSAPPNP-NREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 494
Query: 1018 EFIR-KLQDFEVKEKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
+ + Q V + L+ S + W ++G+ Y + G +
Sbjct: 495 RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 554
Query: 1076 IRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTK 1132
IR D+G Y+C+ + AE V V+ P I ++Q +G E +
Sbjct: 555 IRK---EDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKH 611
Query: 1133 GDAL---VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKC 1185
+L V W KD + N ++ D L I+ D G Y+C E+
Sbjct: 612 DPSLKLTVSWLKDDEPLYIGNRMKKEDD----SLTIFGVAERDQGSYTCVASTELDQDLA 667
Query: 1186 TAILTV 1191
A LTV
Sbjct: 668 KAYLTV 673
Score = 52.4 bits (120), Expect = 2e-05
Identities = 68/267 (25%), Positives = 110/267 (41%), Gaps = 28/267 (10%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P +PR+ +++ RSV L W ++N SPIT+Y+++F+ + + W GSV+
Sbjct: 677 PDRPRDLELTDLAERSVRLTWIPGDAN-NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN 735
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTA-PLEIRMVGS-- 1980
+ + FR+ A N VG S P S+ E++ T +PP + P +++ G+
Sbjct: 736 S-AVLRLSPYVNYQFRVIAINEVGSSHP----SLPSERYRTSGAPPESNPGDVKGEGTRK 790
Query: 1981 NIVMTSWGTP--EWDGGAPLLGYNIA-IRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTY 2037
N + +W TP P L Y + R T+ W V V ++ + Y
Sbjct: 791 NNMEITW-TPMNATSAFGPNLRYIVKWRRRETREAW---NNVTVWGSRYVVGQTPVYVPY 846
Query: 2038 MIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVXXXXXXXXXXXXXWLREH 2097
IR+ A N+ G + EP VI G D TEV W R +
Sbjct: 847 EIRVQAENDFG-----KGPEPESVIGYSGE--DYPRAAPTEVKVRVMNSTAISLQWNRVY 899
Query: 2098 N--MDADIRSYARGSLLRRDEYFFRIW 2122
+ + +R Y R R +W
Sbjct: 900 SDTVQGQLREY-RAYYWRESSLLKNLW 925
Score = 43.6 bits (98), Expect = 0.008
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + G+P P++ WYK G L +DK + +RI + S +Y
Sbjct: 325 GMDLLLECIASGVPTPDIAWYKKGGDLPSDK---AKFENFNKALRITNVSEEDSGEYFCL 381
Query: 1647 ASNTAGTSSVEVTLKVYDKP 1666
ASN G+ ++++V P
Sbjct: 382 ASNKMGSIRHTISVRVKAAP 401
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC G P P I W+++ + PS + +++ N A L I V ED+G + C
Sbjct: 325 GMDLLLECIASGVPTPDIAWYKKGGDL-PSD--KAKFENFNKA-LRITNVSEEDSGEYFC 380
Query: 584 VAKNAAGFASSTTELIVEA 602
+A N G T + V+A
Sbjct: 381 LASNKMGSIRHTISVRVKA 399
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 513 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 569
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 570 ILGKAENQVRLEVKDP 585
Score = 37.1 bits (82), Expect = 0.69
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 5/88 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS--VKNITKTQT 1438
PS P + + + + +IN+ WD PE+ N +I Y ++Y + T+ V+N + QT
Sbjct: 981 PSAPRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGTKVGKQIVENFSPNQT 1039
Query: 1439 --SIQNLKTNSSYRFRAYAVNEVDISDA 1464
++Q S YRF A +V +A
Sbjct: 1040 KFTVQRTDPVSRYRFTLSARTQVGSGEA 1067
Score = 34.7 bits (76), Expect = 3.7
Identities = 30/133 (22%), Positives = 54/133 (40%), Gaps = 5/133 (3%)
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
+E P + P + ++ V + I + NP PS W RN+ + ++
Sbjct: 78 IEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRV 137
Query: 882 NFDGENIELVI---TNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK-VTFVKHLQKS 937
+ + LVI + E G+Y+C A N G ++ R+ + V K + K
Sbjct: 138 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDP 196
Query: 938 YETEEGKTVILEC 950
+EG + L+C
Sbjct: 197 VVVQEGAPLTLQC 209
>AF151909-1|AAD34146.1| 404|Homo sapiens CGI-151 protein protein.
Length = 404
Score = 124 bits (299), Expect = 4e-27
Identities = 95/336 (28%), Positives = 148/336 (44%), Gaps = 20/336 (5%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQD-FQMYYD 561
S + MAP F KL+ +G V F C+V G P+P+I WF+ I P D + + D
Sbjct: 15 SWKTGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRD 74
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA-------PLSDHGSEMTVX 614
D +L +D G +T +A N G S T L+V+A P S G
Sbjct: 75 LDGTCSLHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRR 134
Query: 615 XXXXXXXXXXXADILEG--IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGE 672
+ ++ P F + P V EG ++C++ +P PD++W G+
Sbjct: 135 PRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGK 194
Query: 673 EIVPDENISVAI-ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE 731
+ PD + + E+ +H L I V G YT +A NR G+ S + L + E
Sbjct: 195 PVRPDSAHKMLVRENGVHS----LIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKE 250
Query: 732 -KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV----KALPTKSDGDT 786
+PP IE L++ V G V L +V+G P P I W K N+ + + D
Sbjct: 251 AHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHG 310
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+ +++ +D G YT+ A+N GI +A + V
Sbjct: 311 YICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV 346
Score = 89.8 bits (213), Expect = 9e-17
Identities = 87/333 (26%), Positives = 143/333 (42%), Gaps = 45/333 (13%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ P F K K + EG + CR+ P+P I W G++I P + I+ D+
Sbjct: 19 GMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSD-HYTIQRDLDG 77
Query: 691 YCSVLKITNVKKFQEGTYT-----------------VVAVNREGEASL-----PIVLKIK 728
CS L T +G YT V AVN+ G + P V + +
Sbjct: 78 TCS-LHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPR 136
Query: 729 T------GEKEP-------PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
+ E EP P ++ + V++G+ + +V G P P ++W + KPV
Sbjct: 137 SRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPV 196
Query: 776 KALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ + HS+ I++P +D G+YT A N G S + V +E +
Sbjct: 197 RPDSAHKMLVRENGVHSL-IIEPVTSRDAGIYTCIATNRAGQNSFSLELVVA--AKEAHK 253
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS-ETITQNFDGENIEL 890
PP+FI + Q V + ++L RV P P I W + NE ++ S + ++ + D
Sbjct: 254 PPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYIC 313
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
++ ++ D+G Y A N AG S AR+ +
Sbjct: 314 LLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV 346
Score = 85.8 bits (203), Expect = 2e-15
Identities = 67/244 (27%), Positives = 103/244 (42%), Gaps = 27/244 (11%)
Query: 499 EKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM 558
E +E+ P F++ +G + +C+V G P P ++W ++P +M
Sbjct: 145 ENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKM 204
Query: 559 YYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXX 618
++ V +L+I V DAG +TC+A N AG S + EL V A H
Sbjct: 205 LVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLEL-VVAAKEAHK---------- 253
Query: 619 XXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE 678
PP F +K + V +G + LECR++ +P P I W + E +
Sbjct: 254 --------------PPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHST 299
Query: 679 NISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+ V++ D H Y +L I K G YTV A N G S L + T + Q
Sbjct: 300 D-RVSMHQDNHGYICLL-IQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQSQST 357
Query: 739 EPLK 742
+P K
Sbjct: 358 KPKK 361
Score = 52.8 bits (121), Expect = 1e-05
Identities = 35/153 (22%), Positives = 69/153 (45%), Gaps = 6/153 (3%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
EP +E P F+ ++TV+E ++ +V+ P P ++W + + + P
Sbjct: 147 EPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLV 206
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV----TFVKHLQKSYE 939
+ +I + D+G Y C+A+N AG++S + + ++ F++ LQ +
Sbjct: 207 RENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNT-G 265
Query: 940 TEEGKTVILECQTSHTVSTKWYHNKKEISGMDH 972
+G V LEC+ + + KKE + H
Sbjct: 266 VADGYPVRLECRVLGVPPPQIFW-KKENESLTH 297
Score = 49.6 bits (113), Expect = 1e-04
Identities = 47/187 (25%), Positives = 74/187 (39%), Gaps = 16/187 (8%)
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKA----TYENRXXXXXXX-XXXXX 1544
++T + + + C G+P P ++W DGK ++ A EN
Sbjct: 164 DLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRD 223
Query: 1545 XXXYKCIAFNDHGEVETS--CVVGIQQ--KPVITISNEDIKQKHKVGDEWLV--TAVIEG 1598
Y CIA N G+ S VV ++ KP + I Q V D + V + G
Sbjct: 224 AGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEK---LQNTGVADGYPVRLECRVLG 280
Query: 1599 IPPPEVIWYKNGNKLENDKEYNITTKEKTSVI--RIKELKRSHSSKYTIEASNTAGTSSV 1656
+PPP++ W K L + + ++ I I+ + + YT+ A N AG S
Sbjct: 281 VPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSC 340
Query: 1657 EVTLKVY 1663
L VY
Sbjct: 341 TARLDVY 347
Score = 47.6 bits (108), Expect = 5e-04
Identities = 48/191 (25%), Positives = 78/191 (40%), Gaps = 16/191 (8%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F++ D V+E + ++ +++ T D+ W+ DG+ ++P + + L
Sbjct: 156 PHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLI 215
Query: 1076 IRNTSVHDEGEYSCILRD----ESCTAEVTV----VELPPEIITRLQNQKVNKGNKATFE 1127
I + D G Y+CI + S + E+ V PP I +LQN V G E
Sbjct: 216 IEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLE 275
Query: 1128 IE-LTKGDALVRWFKDGSEIQFS-NHIQLTIDGKKQ-KLKIYDCDLDDAGEYSC----EV 1180
L + W K+ + S + + + D L I +DAG Y+ E
Sbjct: 276 CRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEA 335
Query: 1181 GNSKCTAILTV 1191
G CTA L V
Sbjct: 336 GIVSCTARLDV 346
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/107 (25%), Positives = 50/107 (46%), Gaps = 7/107 (6%)
Query: 821 TVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE--- 877
T + + + P F + + + E + RV NP P I W+++ + ISP
Sbjct: 10 TADAASWKTGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHY 69
Query: 878 TITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
TI ++ DG ++ + +D D G+Y +A+N G+ S R+ +
Sbjct: 70 TIQRDLDGTCSLHTTASTLD---DDGNYTIMAANPQGRISCTGRLMV 113
Score = 36.7 bits (81), Expect = 0.91
Identities = 15/49 (30%), Positives = 24/49 (48%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY 1529
+P E LK+ + TC G P+PK+ W++DGK++ Y
Sbjct: 21 APFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHY 69
>AL713647-1|CAD28458.1| 1232|Homo sapiens hypothetical protein
protein.
Length = 1232
Score = 123 bits (297), Expect = 6e-27
Identities = 132/589 (22%), Positives = 232/589 (39%), Gaps = 35/589 (5%)
Query: 821 TVEEPTEENA-EP----PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
TV TE A EP P+ + Q+ TV K + T P P+ W ++ + I+
Sbjct: 644 TVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQ 703
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHL- 934
+ D L I D+ DSG Y C NSAG S ++TI K T + +
Sbjct: 704 GGKYKLSEDKGGFFLEIHKTDTS-DSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVS 762
Query: 935 -QKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXD 993
QK+ E K +++ + S E + + +E
Sbjct: 763 TQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAA 822
Query: 994 VGVIKCIVKDQETSTMLVVKE--TIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWER 1051
+ K IV ++ T T +E T E + E +L+ I T D W
Sbjct: 823 TSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGAT-DAKWVL 881
Query: 1052 DGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES----CTAEVTVV-ELP 1106
+G + +Y + G + L I+ S DEG +CI + + C ++T+ EL
Sbjct: 882 NG-VELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELS 940
Query: 1107 --PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKL 1163
P I++ ++Q +N+G F E++ + + WFK+ I S+++ ++ L
Sbjct: 941 DAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSL 1000
Query: 1164 KIYDCDLDDAGEYSCEVGN--SKCTAILT------VEEPSINFTLRLP-EFILVPANTDA 1214
+I + + D+G+Y+ + N +C+A + VEEPS LR + L + +
Sbjct: 1001 EIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQ 1060
Query: 1215 YLTVEIPDETLDVTWYKKKSVIEDTE-KFTLISDVKKRTL---IIRKCTEDDQCEYTCVL 1270
+ + + + + S TE KF +S ++ + +
Sbjct: 1061 SVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQ 1120
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
L++ ++ LK + PPKI + I G +T+ + P P W + I
Sbjct: 1121 LESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHS 1180
Query: 1331 CKHTKPSIDSKS--ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ + I++ +L I V+ D G+Y L L N G +N+ I
Sbjct: 1181 QEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 1229
Score = 103 bits (247), Expect = 7e-21
Identities = 171/833 (20%), Positives = 326/833 (39%), Gaps = 71/833 (8%)
Query: 736 QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK 795
+++ +SM V +GES S G P PT+TW + + + T + +
Sbjct: 371 RILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEIS 430
Query: 796 KVK--DEGVYTLKAENSEGIAETSAVITVEEP--TEENAEPPLFINRFQEITVKEKGTIK 851
V+ DEG Y++ ENSEG E +T+++ TE+ P + + E VK +K
Sbjct: 431 SVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRV-KSPEPRVKSPEAVK 489
Query: 852 LVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNS 911
RV ++P PS + + +SP+ET + E ++ + + +I K AS
Sbjct: 490 SPKRV-KSPEPS-----HPKAVSPTET--KPTPTEKVQHLPVSAPPKITQF-LKAEASKE 540
Query: 912 AGKSSHGARVTI-DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGM 970
K + ++ ++VT+ K +K E + T K + + G
Sbjct: 541 IAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQ---FHYSADGTYELKINNLTESDQGE 597
Query: 971 DHREIIQEGRXXXXXXXXXXXXDVGVIKCIVK-------DQETSTMLVVKETIPE----- 1018
EI EG + + + K DQ+T+ V ++T P+
Sbjct: 598 HVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPI 657
Query: 1019 -----FIRKLQDFEVKEKDVAILEVEINSETADV-VWERDGEII-KPKKNKYDFEKRGHI 1071
+ LQD V VA V+ E +W +DG+ I + K K +K G
Sbjct: 658 SSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFF 717
Query: 1072 RKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELT 1131
L I T D G Y+C +++ + + + +L + I + QKV+ + T EI
Sbjct: 718 --LEIHKTDTSDSGLYTCTVKNSAGSVSSSC-KLTIKAIKDTEAQKVS--TQKTSEITPQ 772
Query: 1132 KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY--SCEVGNSKCTAI- 1188
K A+V+ ++ S I+++ ++KL + + +A + S EV S T++
Sbjct: 773 K-KAVVQEEISQKALR-SEEIKMSEAKSQEKLALKE----EASKVLISEEVKKSAATSLE 826
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDE------------TLDVTWYKKKSVI 1236
++ I T + E + A A+ T +E D W +
Sbjct: 827 KSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDAKWVLNGVEL 886
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-----VEFPPKIV 1291
++E++ +TL I++ + D+ TC+ + K + ++ + P +
Sbjct: 887 TNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFI 946
Query: 1292 DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVE 1351
R I G +V + P P EW N+ I + S SL I+
Sbjct: 947 SQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNAS 1006
Query: 1352 NTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+D+G Y ++ +N G ++ +L P + +L S ++ + +
Sbjct: 1007 VSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLR-TSGDTSLQGSFSSQSVQMS 1065
Query: 1412 IIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYY 1471
+ ++ S+ + S Q++ + + + + IS+ ++
Sbjct: 1066 ASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESST 1125
Query: 1472 KVIKETKIQS--PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ + I+ P +E +I+ + + + + C F G P P+VTW G+K+
Sbjct: 1126 SKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI 1178
Score = 80.6 bits (190), Expect = 6e-14
Identities = 90/450 (20%), Positives = 177/450 (39%), Gaps = 33/450 (7%)
Query: 671 GEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTG 730
GE N+ ++ ++ V KI+ KK + T T V R+ E P + K
Sbjct: 604 GEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT-TESTVTRKTEPKAPEPISSK-- 660
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSI 789
P ++ L+ V + + G PRPT W K+ K + + K D
Sbjct: 661 ----PVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGF 716
Query: 790 TI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+ + D G+YT +NS G +S +T++ + A+ + + EIT ++K
Sbjct: 717 FLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQK-VSTQKTSEITPQKKA 775
Query: 849 TIK--LVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
++ + + R+ ++ ++ E ++ E ++ E ++ + + ++ K
Sbjct: 776 VVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVK---KSAATSLE----KS 828
Query: 907 VASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKE 966
+ K+S + +V +K EG+ ++L+ + KW N E
Sbjct: 829 IVHEEITKTSQASE---EVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDAKWVLNGVE 885
Query: 967 ISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCI-------VKDQETSTMLVVKETIPEF 1019
++ + G D G++ CI VK Q T+ P F
Sbjct: 886 LTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAF 945
Query: 1020 IRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRN 1078
I + + + E + EI+ E + ++ W ++ I N + ++ L IRN
Sbjct: 946 ISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSN-VSISRSRNVYSLEIRN 1004
Query: 1079 TSVHDEGEYSCILRD--ESCTAEVTVVELP 1106
SV D G+Y+ ++ C+A +++ LP
Sbjct: 1005 ASVSDSGKYTIKAKNFRGQCSATASLMVLP 1034
Score = 79.4 bits (187), Expect = 1e-13
Identities = 148/701 (21%), Positives = 259/701 (36%), Gaps = 54/701 (7%)
Query: 639 KPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKIT 698
KP++ V EG C P P + WL KG+ + V Y S +I+
Sbjct: 375 KPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTK----YKSTFEIS 430
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQV 758
+V+ EG Y+VV N EG+ L I+ V P + V+ E + S +
Sbjct: 431 SVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPR---VKSPEPRVKSPEA 487
Query: 759 VGNPR----PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
V +P+ P + K P + PT ++ H + + P K+ LKAE S+ IA
Sbjct: 488 VKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQH-LPVSAPPKI----TQFLKAEASKEIA 542
Query: 815 E-----TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKL-VARVTRNPVPSITWYR 868
+ S+V+ +E T L N + GT +L + +T +
Sbjct: 543 KLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEHVCEI 602
Query: 869 NNEIISPSETITQNFDGENIELVITNVD--SEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+ E S+T Q F G+ + + V SE D K S K+ A I
Sbjct: 603 SGE-GGTSKTNLQ-FMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPIS-S 659
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHTVSTK-WYHNKKEISGMDHREIIQEGRXXXXX 985
K V LQ + + + T T W + K I+ ++ ++
Sbjct: 660 KPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLE 719
Query: 986 XXXXXXXDVGVIKCIVKDQETS-------TMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
D G+ C VK+ S T+ +K+T + + + E+ + A+++
Sbjct: 720 IHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQE 779
Query: 1039 EINSETADVVWERDGEI-IKPKKNKYDFEKRGHIRKLYIR---NTSVHDEGEYSCILRDE 1094
EI+ + R EI + K++ + K+ I S E S + +
Sbjct: 780 EISQKAL-----RSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEI 834
Query: 1095 SCTAEVT-VVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQ 1153
+ T++ + V EI +N+G + + + G +W +G E+ S +
Sbjct: 835 TKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIA-GATDAKWVLNGVELTNSEEYR 893
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTV--EEPSINFTLRLPEFIL 1207
+ G Q L I D G +C + G KC LT+ E + P
Sbjct: 894 YGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQN 953
Query: 1208 VPANTDAYLTVEIPDE-TLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEY 1266
+ + T EI E + ++ W+K I + ++ +L IR + D +Y
Sbjct: 954 INEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 1013
Query: 1267 TCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
T + + ++ P + + RE ++ D +L
Sbjct: 1014 TIKAKNFRGQCSATASLMVL-PLVEEPSREVVLRTSGDTSL 1053
Score = 69.7 bits (163), Expect = 1e-10
Identities = 76/299 (25%), Positives = 131/299 (43%), Gaps = 15/299 (5%)
Query: 319 EAAKVKKQVF--VPPKLPDVEKTELEQPLFSYEDIVESK-KDENEIIQEKQTLEELPKED 375
EA KV Q + P+ V + E+ Q E+I S+ K + ++ +++ + L E+
Sbjct: 757 EAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEE 816
Query: 376 VPEQYTITPRKSSAQKIDEIVDEVTIKKRLNP-FEIFYTPVEVRCGDTVFAVYSYVAETD 434
V + + KS + + + + R + + F T + + G + + TD
Sbjct: 817 VKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATD 876
Query: 435 EAINLVEGERLYILDTSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDK 494
A ++ G L T+++++ Y + A + DE T K E I K
Sbjct: 877 -AKWVLNGVEL----TNSEEYRYGVSGSDQTLTIKQASH-RDEGILTCI--SKTKEGIVK 928
Query: 495 LPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ 554
++ S+E S AP F+ + R ++ +G V F C++ G P P+I WF+ I S
Sbjct: 929 CQ-YDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISS 987
Query: 555 DFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTV 613
+ + NV +L IR D+G +T AKN G S+T L+V PL + S V
Sbjct: 988 NVSI-SRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV-LPLVEEPSREVV 1044
Score = 64.9 bits (151), Expect = 3e-09
Identities = 64/281 (22%), Positives = 114/281 (40%), Gaps = 14/281 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIEL-TKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P I R+++ +V G F + + +K A V+W+ +G E+Q S+ I T L+I
Sbjct: 183 PRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEI 242
Query: 1166 YDCDLDDAGEYSCEVGNSKCTA--ILTVEEPSINFTLRLPE--FILVPANTDAYLTVEIP 1221
DC DD+G Y N K A T++ ++T + VP + LT
Sbjct: 243 LDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELT---R 299
Query: 1222 DETLDVTWYKKKSVIEDTEKFTLI-SDVKKRTLIIRKCTEDDQCEYTCVLLDAKS----T 1276
E V+ +KK S +E + + S + + + E L+ KS +
Sbjct: 300 TEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKS 359
Query: 1277 TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
T K++ +I+ R + G D P P W+ +++ +
Sbjct: 360 TTRKIKTT-LAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQV 418
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ ++ I V+ +D G Y + +EN+ G + E +TI
Sbjct: 419 TTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTI 459
Score = 64.5 bits (150), Expect = 4e-09
Identities = 78/402 (19%), Positives = 144/402 (35%), Gaps = 17/402 (4%)
Query: 1282 EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
E + P IV ++ + S V P+P W + K I + K S D
Sbjct: 655 EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKG 714
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD-KPSPPGKPNILEIDSSSINIC 1400
L I K + +D+G+Y ++N+ G +TI K + K + + +
Sbjct: 715 GFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKK 774
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
E + ++ E + E +++K + +K +++ V+E +
Sbjct: 775 AVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHE-E 833
Query: 1461 ISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK 1520
I+ S+ +E + E K S ++ + + L G K W +G
Sbjct: 834 ITKTSQASEEVRTHAEIKAFST-------QMSINEGQRLVLKANIAGATDAK--WVLNGV 884
Query: 1521 KLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK--PVIT 1574
+L ++ + CI+ G V+ + + ++
Sbjct: 885 ELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPA 944
Query: 1575 ISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKE 1634
++ Q G L T I G P PE+ W+KN + +I+ + I+
Sbjct: 945 FISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRN 1004
Query: 1635 LKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
S S KYTI+A N G S +L V +P V++R
Sbjct: 1005 ASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLR 1046
Score = 64.1 bits (149), Expect = 5e-09
Identities = 81/376 (21%), Positives = 139/376 (36%), Gaps = 59/376 (15%)
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
TL I++ D G TC++K G +L + LSD
Sbjct: 902 TLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSD-------------------- 941
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
P F +P++Q ++EG ++L C + P P+I W I N+S++
Sbjct: 942 ------APAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR 995
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+++ L+I N G YT+ A N G+ S L + P V EP + +++
Sbjct: 996 NVYS----LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL------PLVEEPSREVVL 1045
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
R L G+ +K + + S S+T +K + + + +++
Sbjct: 1046 RTSGDTSLQ----GSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQ 1101
Query: 807 AE----NSEGIAETSAVITVEEPTEENAE------PPLFINRFQEITVKEKGTIKLVARV 856
+S S + +E T + + PP +I++ E + +
Sbjct: 1102 ESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAF 1161
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIE----LVITNVDSEIDSGDYKCVASNSA 912
T P P +TW I E F EN + L+I +V + D G Y N
Sbjct: 1162 TGEPTPEVTWSCGGRKIHSQE--QGRFHIENTDDLTTLIIMDVQKQ-DGGLYTLSLGNEF 1218
Query: 913 GKSSHGARVTIDVEKV 928
G S A V I + +
Sbjct: 1219 GSDS--ATVNIHIRSI 1232
Score = 56.0 bits (129), Expect = 1e-06
Identities = 70/320 (21%), Positives = 130/320 (40%), Gaps = 32/320 (10%)
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYE-------REYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
L + T++ K EV+ P +D+ R +R+ G + +++ Q+ P +W
Sbjct: 159 LKTQKTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYH 218
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD--VEMNVTILDKP 1381
N +++ + S +L I D+G Y+ N G A ++VT D
Sbjct: 219 NGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYT 278
Query: 1382 SPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS----VKN-ITKT 1436
+ + E+ S PE T T Y V +++ E S VK+ +T+T
Sbjct: 279 TYASQRRDEEVPRSVF------PELT--RTEAYAVSSFKKTSEMEASSSVREVKSQMTET 330
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
+ S+ + + ++S ++ A+ E + + S T + +T + + + KP +++T
Sbjct: 331 RESLSSYEHSASAEMKSAALEEKSLEEKSTTRKI-----KTTLAARILTKP-RSMTVYEG 384
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAK----ATYENRXXXXXXXXXXXXXXXYKCIA 1552
E +C G P P VTW R G+ L T+ T + + Y +
Sbjct: 385 ESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVV 444
Query: 1553 FNDHGEVETSCVVGIQQKPV 1572
N G+ E + IQ+ V
Sbjct: 445 ENSEGKQEAEFTLTIQKARV 464
Score = 53.2 bits (122), Expect = 1e-05
Identities = 87/445 (19%), Positives = 151/445 (33%), Gaps = 33/445 (7%)
Query: 540 QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELI 599
++TW++ +K + FQ +Y D L I + D G C G + + + +
Sbjct: 557 EVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEHVCEISGEGGTSKTNLQFM 616
Query: 600 VEAPLSDHGSEMTVXXXXXXXXXXXXADILE----GIPPTFSKKP----KAQYVDEGSDI 651
+A S H + + + P S KP Q SD
Sbjct: 617 GQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDS 676
Query: 652 LLECRLVAI--PEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYT 709
+ + + A P P W G+ I + + D + L+I G YT
Sbjct: 677 VAKFAVKATGEPRPTAIWTKDGKAIT--QGGKYKLSEDKGGF--FLEIHKTDTSDSGLYT 732
Query: 710 VVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNP-RPTITW 768
N G S L IK + Q + K+ + + ++ ++ R
Sbjct: 733 CTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIK 792
Query: 769 CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL-KAENSEGIAETSAVITVEEPTE 827
K + L K + +L ++VK +L K+ E I +TS E
Sbjct: 793 MSEAKSQEKLALKEEAS----KVLISEEVKKSAATSLEKSIVHEEITKTS---QASEEVR 845
Query: 828 ENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGEN 887
+AE F ++++ E + L A + W N ++ SE G +
Sbjct: 846 THAEIKAFST---QMSINEGQRLVLKANIA--GATDAKWVLNGVELTNSEEYRYGVSGSD 900
Query: 888 IELVITNVDSEIDSGDYKCVASNSAG--KSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
L I S D G C++ G K + ++ ++ +S EG+
Sbjct: 901 QTLTIKQA-SHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQN 959
Query: 946 VILECQTSHTVS--TKWYHNKKEIS 968
V+ C+ S S +W+ N IS
Sbjct: 960 VLFTCEISGEPSPEIEWFKNNLPIS 984
Score = 51.2 bits (117), Expect = 4e-05
Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 4/120 (3%)
Query: 486 KKLNEKIDKLPVFEK--PTSEEQ-SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQIT 542
KK ++K + V K P + E S P+ V L+ S +F + G PRP
Sbjct: 634 KKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI 693
Query: 543 WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
W + I +++ +D L I + D+G +TC KN+AG SS+ +L ++A
Sbjct: 694 WTKDGKAITQGGKYKL-SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKA 752
Score = 43.2 bits (97), Expect = 0.010
Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 499 EKPTSEE--QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDF 556
EK T+ + ++A + K R +G + +F C +G P P +TW R+ ++ S
Sbjct: 357 EKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARH 416
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
Q+ +T I V D G ++ V +N+ G + L ++
Sbjct: 417 QV-TTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ 460
Score = 43.2 bits (97), Expect = 0.010
Identities = 18/66 (27%), Positives = 29/66 (43%)
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
+G P P V W + G L + +TT + S I ++ S Y++ N+ G
Sbjct: 394 DGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEA 453
Query: 1657 EVTLKV 1662
E TL +
Sbjct: 454 EFTLTI 459
Score = 40.3 bits (90), Expect = 0.074
Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD-DNVATLVIREVFPEDAGTF 581
+G + C G P P++TW I + + + ++ D++ TL+I +V +D G +
Sbjct: 1151 EGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLY 1210
Query: 582 TCVAKNAAGFASSTTELIVEA 602
T N G S+T + + +
Sbjct: 1211 TLSLGNEFGSDSATVNIHIRS 1231
Score = 37.5 bits (83), Expect = 0.52
Identities = 17/73 (23%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKE--YNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
V G P PEV W G K+ + ++ ++I + + + I ++++ YT+ N
Sbjct: 1157 VACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 1216
Query: 1650 TAGTSSVEVTLKV 1662
G+ S V + +
Sbjct: 1217 EFGSDSATVNIHI 1229
Score = 36.3 bits (80), Expect = 1.2
Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 3/70 (4%)
Query: 1592 VTAVIEG--IPPPEVIWYKNGNKLENDKEYNI-TTKEKTSVIRIKELKRSHSSKYTIEAS 1648
+T V+E + EV WYK+G KL+ + + + + T ++I L S ++ E S
Sbjct: 544 LTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEHVCEIS 603
Query: 1649 NTAGTSSVEV 1658
GTS +
Sbjct: 604 GEGGTSKTNL 613
Score = 34.3 bits (75), Expect = 4.9
Identities = 18/67 (26%), Positives = 28/67 (41%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
++ P EV WY NG +L+ + + T + I + S Y +N G +S
Sbjct: 206 VQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEAS 265
Query: 1656 VEVTLKV 1662
TL V
Sbjct: 266 DYATLDV 272
>Y00815-1|CAA68754.1| 1897|Homo sapiens put. LAR preprotein (AA -16 to
1881) protein.
Length = 1897
Score = 123 bits (296), Expect = 8e-27
Identities = 211/1018 (20%), Positives = 385/1018 (37%), Gaps = 98/1018 (9%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTID-GKKQKLK 1164
P I ++Q G A+F + T + + W K G ++ + D G L+
Sbjct: 23 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLR 82
Query: 1165 IYDCDLD-DAGEYSCEVGNS----KCTAILTVEE--------PSINFTLRLPEFILVPAN 1211
I + D Y C NS +A L+V E PSI+ +L ++ A
Sbjct: 83 IQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLK--VVEKAR 140
Query: 1212 TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
T L + +++W+K ++ I ++ L I E DQ +Y CV
Sbjct: 141 TATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVAT 200
Query: 1272 DAKST-----TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
++ T L V V P+ + G V L P P +W++ ++
Sbjct: 201 NSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAE 260
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
+ K + S ++ T I L G + VT+ P PP
Sbjct: 261 ELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL------GMIEATAQVTVKALPKPPID 314
Query: 1387 PNILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTT-EWISVKNITKTQTSIQNLK 1444
+ E ++S+ + WD +GNS + YY ++Y+ T + V + T+ SI L
Sbjct: 315 LVVTETTATSVTLTWD----SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLS 370
Query: 1445 TNSSYRFRAYAVNEVDISDASE-----TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDI 1499
S Y FR AVN + SE T E ++Q+ + + EP E+
Sbjct: 371 PFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEP 430
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHG 1557
G V +V + D ++ A + Y + +AF G
Sbjct: 431 N-----GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVG 485
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE-VIWYKNGN-KLEN 1615
+ S + ++ + + D Q D + + + +PP E +I Y+ E+
Sbjct: 486 DGPPSPTIQVKTQQGVPAQPADF-QAEVESDTRIQLSWL--LPPQERIIMYELVYWAAED 542
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP--- 1672
+ + + T + TS +++LK ++ + A + G T++ S P P
Sbjct: 543 EDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQK 602
Query: 1673 VIMREISRESVTIEW-KPPLDDGGLELTKYAIEKHEPD-NNRWIKVAD-VDRDVETYCIQ 1729
V+ + +V + W PP D +T+Y++ D +R V D + R+ ++ +
Sbjct: 603 VMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAHEAVDGEDRGRHVVDGISREHSSWDLV 662
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW- 1788
L + EY V A VG ES P++++T DVPS +++ +V++ W
Sbjct: 663 GLEKWTEYRVWVRAHTDVG--PGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWK 720
Query: 1789 --FPSEKNG------------------GSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQK 1828
PS+++G G PII ++ +W+ I
Sbjct: 721 LPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQ---DVMLAEAQWRPEESEDYETT-ISG 776
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
L+ TTY + A G S KI + T P +P ++S + + L+W
Sbjct: 777 LTPETTYSVTVAAYTTKGDGA--RSKPKI-VTTTGAVPGRP-TMMISTTAMNTALLQWHP 832
Query: 1889 PESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGV 1948
P+ G + Y +++ ++ + G + + + IFR++A+N G+
Sbjct: 833 PKELPGE-LLGYRLQYCRA-DEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 890
Query: 1949 SLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW-DGGAPLLGYNIAIRD 2007
E + + +PS L + + ++ +W P + ++ Y + RD
Sbjct: 891 GEEFEKE---IRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 947
Query: 2008 VTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGE 2065
+ E+ + +T +F + L + TY I++ A G S PL + +P E
Sbjct: 948 INSQ--QELQNITTDT-RFTLTGLKPDTTYDIKVRAWTSKG-SGPLSPSIQSRTMPVE 1001
Score = 73.3 bits (172), Expect = 9e-12
Identities = 80/301 (26%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F K P+ Q G C+ P+P I W+ KG++ V + V IE D S
Sbjct: 23 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKK-VSSQRFEV-IEFD-DGAGS 79
Query: 694 VLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQG 749
VL+I ++ + E Y A N GE + L + E+ P P + + +V +
Sbjct: 80 VLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKA 139
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYTL 805
+ + GNP P I+W K+ PV P S+G + ++ + D+G Y
Sbjct: 140 RTATMLCAAGGNPDPEISWFKDFLPVD--PATSNGRIKQLRSGALQIESSEESDQGKYEC 197
Query: 806 KAENSEGI---AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
A NS G A + + V + PP QE V G++ L P+P
Sbjct: 198 VATNSAGTRYSAPANLYVRVRRVAPRFSIPP----SSQE--VMPGGSVNLTCVAVGAPMP 251
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W E ++ + + G N+ L ++NV + S +Y CVA +S G A+VT
Sbjct: 252 YVKWMMGAEELTKEDEMPV---GRNV-LELSNV---VRSANYTCVAISSLGMIEATAQVT 304
Query: 923 I 923
+
Sbjct: 305 V 305
Score = 71.7 bits (168), Expect = 3e-11
Identities = 81/317 (25%), Positives = 130/317 (41%), Gaps = 36/317 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY-YDDDNVATL 568
P+F++ + G F CQ G P+P+ITW ++ + SQ F++ +DD + L
Sbjct: 23 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVS-SQRFEVIEFDDGAGSVL 81
Query: 569 VIREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
I+ + D + C A N+ G E+ A LS E
Sbjct: 82 RIQPLRVQRDEAIYECTATNSLG------EINTSAKLSVLEEEQ---------------- 119
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ G P + P+ + V++ + C P+P+I+W FK V + I+
Sbjct: 120 LPPGFP-SIDMGPQLKVVEKARTATMLCAAGGNPDPEISW-FKDFLPVDPATSNGRIKQ- 176
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+ L+I + ++ +G Y VA N G S P L ++ P I P S V
Sbjct: 177 --LRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPP-SSQEV 233
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G SV L+ VG P P + W + + TK D +L+ V YT
Sbjct: 234 MPGGSVNLTCVAVGAPMPYVKWMMGAEEL----TKEDEMPVGRNVLELSNVVRSANYTCV 289
Query: 807 AENSEGIAETSAVITVE 823
A +S G+ E +A +TV+
Sbjct: 290 AISSLGMIEATAQVTVK 306
Score = 64.5 bits (150), Expect = 4e-09
Identities = 62/254 (24%), Positives = 103/254 (40%), Gaps = 18/254 (7%)
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPSKPEGPVIM-REISRESVTIEWKPPLDDGGLELTKYA 1702
T+ A T G + V + P P +M + + ++W PP + G EL Y
Sbjct: 786 TVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPG-ELLGYR 844
Query: 1703 IEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT 1762
++ D R D +D + + + L++ Y+FR+ A+N G E E E I+T
Sbjct: 845 LQYCRADEAR-PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE---IRT 900
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKVEIKQEGKKWKXXXXX 1819
D+PS + + + W P +E+NG II Y V + + +
Sbjct: 901 PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG--RIISYTVVFRDINSQQELQNIT 958
Query: 1820 XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQ--PRNFVVSES 1877
+ L +TTY ++ A G+ P + +I P Q +NF V+ +
Sbjct: 959 TDTRFTLTGLKPDTTYDIKVRAWTSKGSG-PLSP----SIQSRTMPVEQVFAKNFRVAAA 1013
Query: 1878 TSRSVTLKWTEPES 1891
SV L W P+S
Sbjct: 1014 MKTSVLLSWEVPDS 1027
Score = 43.2 bits (97), Expect = 0.010
Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 10/107 (9%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FS P +Q V G + L C V P P + W+ EE+ E +M +
Sbjct: 220 VAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTK--------EDEMPVG 271
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+VL+++NV + YT VA++ G + +K K P ++
Sbjct: 272 RNVLELSNV--VRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLV 316
>AL163282-1|CAB90436.1| 812|Homo sapiens human CHD2-52 down syndrome
cell adhesion molecule protein.
Length = 812
Score = 123 bits (296), Expect = 8e-27
Identities = 148/617 (23%), Positives = 244/617 (39%), Gaps = 55/617 (8%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G + L C+ + PEPD WL +N+ + + + L I N++ G+
Sbjct: 69 GQRVELPCKALGHPEPDYRWL--------KDNMPLELSGRFQKTVTGLLIENIRPSDSGS 120
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
Y NR G A + L +K K I P K + G V LS V G ++
Sbjct: 121 YVCEVSNRYGTAKVIGRLYVKQPLK---ATISPRK-VKSSVGSQVSLSCSVTGTEDQELS 176
Query: 768 WCKNNKPVK-ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPT 826
W +N + + + G H I+ D G Y + A+ + +E+ T
Sbjct: 177 WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGT 236
Query: 827 EENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII--SPSETITQNFD 884
P I+ F E V + L+ V P+P+ITW +++ I S I+Q
Sbjct: 237 ------PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 290
Query: 885 GENIELVITNVDSE--IDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
E + N+ S D G Y+C A+NSAG + AR I+V ++ + K+
Sbjct: 291 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQAR--INVRGPASIRPM-KNITAIA 347
Query: 943 GKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC- 999
G+ + C+ S KWY N + +HR++ E D G C
Sbjct: 348 GRDTYIHCRVIGYPYYSIKWYKN-SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN 406
Query: 1000 -IVKDQ-ETSTMLVVKETIPEFIRKLQ--DFEVKEKDVAILEVEINSETADVVWERDGEI 1055
+V+ Q TS + V +P FI+ + F + ++ V + W++DG
Sbjct: 407 VLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRP 466
Query: 1056 IKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITR 1112
I P + L I N S+ G Y+CI R+E+ E +V +PP+ + +
Sbjct: 467 I-PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ 525
Query: 1113 LQNQKVNKGNKATF--EIELTKGDALVRWFKDGSEI-QF-----SNHIQLTIDGKKQKLK 1164
++Q G E +V F G+ + QF + IQ+ +G L
Sbjct: 526 PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG---SLL 582
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
I +D+G Y C+V N + S+ T+++P I NT L + +
Sbjct: 583 IKHVVEEDSGYYLCKVSNDVGADV----SKSMYLTVKIPAMITSYPNTT--LATQGQKKE 636
Query: 1225 LDVTWYKKKSVIEDTEK 1241
+ T + +K +I EK
Sbjct: 637 MSCTAHGEKPIIVRWEK 653
Score = 112 bits (270), Expect = 1e-23
Identities = 154/769 (20%), Positives = 294/769 (38%), Gaps = 59/769 (7%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P +++ G+ V L + +G+P P W K+N P++ + T + +++
Sbjct: 55 PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLEL--SGRFQKTVTGLLIEN 112
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
+ D G Y + N G A+ + V++P + P +++ + L
Sbjct: 113 IRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP-------RKVKSSVGSQVSLSC 165
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
VT ++WYRN EI++P + + G N E +I + + D G Y+C
Sbjct: 166 SVTGTEDQELSWYRNGEILNPGKNV--RITGINHENLIMDHMVKSDGGAYQCFVRKDKLS 223
Query: 915 SSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEI-SGMD 971
+ +V ++ + + + V L C T + W + I G
Sbjct: 224 AQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 282
Query: 972 HR---EIIQEGR-XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI--PEFIRKLQD 1025
HR I EG D GV +C + + + + P IR +++
Sbjct: 283 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKN 342
Query: 1026 F-EVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ +D I I + W ++ ++ + FE G ++ ++ DE
Sbjct: 343 ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV--DE 400
Query: 1085 GEYSC--ILRDESCTAE-VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGD--ALVRW 1139
GEY+C +++ + T++ V V P I + + + G + + GD + W
Sbjct: 401 GEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 460
Query: 1140 FKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT 1199
KDG I S + + L+I + L G Y+C N VE S
Sbjct: 461 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAA----AVEHQSQLIV 516
Query: 1200 LRLPEFILVPANTDA-YLTVEIPDETLD------VTW-YKKKSVIEDTEKFTL---ISDV 1248
P+F++ P + D Y I + + + + W + K + + + L I +
Sbjct: 517 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL 576
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVT 1306
+L+I+ E+D Y C + + +K V+ P I Y +G
Sbjct: 577 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKE 636
Query: 1307 LLVDYQAFPQPNDEW-----IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
+ W I+N ++ + TK + ++L I D+G +
Sbjct: 637 MSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCH 696
Query: 1362 LENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
N+ G + +T+ + P PP + I ++ + +I + W + GNS I Y +E +
Sbjct: 697 AINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFD-GNSPITGYDIECKN 754
Query: 1422 IDTTEWIS---VKNITK--TQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
+ W S K+++ +I ++ +S+Y R YA N + S+ S
Sbjct: 755 -KSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS 802
Score = 84.6 bits (200), Expect = 3e-15
Identities = 154/785 (19%), Positives = 288/785 (36%), Gaps = 79/785 (10%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P I+ ++K G + + L + RW KD ++ S Q T+ G L I
Sbjct: 55 PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LLI 110
Query: 1166 YDCDLDDAGEYSCEVGN----SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP 1221
+ D+G Y CEV N +K L V++P + T+ P + + L+ +
Sbjct: 111 ENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQP-LKATIS-PRKVKSSVGSQVSLSCSVT 168
Query: 1222 D-ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLK 1280
E +++WY+ ++ + K I+ + LI+ + D Y C + K + +
Sbjct: 169 GTEDQELSWYRNGEIL-NPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDY 227
Query: 1281 VEVV--EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK-IIKKCKHTKPS 1337
V+VV + PKI+ E + V+L+ + + P P W ++ I+K H
Sbjct: 228 VQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQ 287
Query: 1338 IDSKSAS----LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEID 1393
+ + + L I + D G+Y+ N+ G + + + S NI I
Sbjct: 288 MITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAI- 346
Query: 1394 SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRA 1453
G T I+ V + +W N+ + N + + +
Sbjct: 347 -------------AGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL-S 392
Query: 1454 YAVNEVDISDASETTEYYKVIKETK-----IQSPTVEKPLKNITTEPNEDIELTCIFGGV 1508
EVD + + + ++ ++ P +P + + + + C+
Sbjct: 393 DVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSG 452
Query: 1509 PQP-KVTWYRDGKKLK-TAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC 1563
P +TW +DG+ + + T +N Y CIA N+ VE
Sbjct: 453 DLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQS 512
Query: 1564 VVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIW-YKNGNKLENDKEYNIT 1622
+ ++ P + D Q G ++ EG P P ++W + G + + +
Sbjct: 513 QLIVRVPPKFVVQPRD--QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALN 570
Query: 1623 TKEKT---SVIRIKELKRSHSSKYTIEASNTAG---TSSVEVTLKVYDK-PSKPEGPVIM 1675
+ + + IK + S Y + SN G + S+ +T+K+ S P +
Sbjct: 571 GRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLAT 630
Query: 1676 REISRE-SVTIEWKPPLDDGGLELTKYAIEKH--EPDNNRW-IKVADVDRDV-ETYCIQK 1730
+ +E S T + P+ + ++ E P+ R+ + +V +V T I
Sbjct: 631 QGQKKEMSCTAHGEKPI------IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILP 684
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
F A N G E I+ T + P + ++ + W
Sbjct: 685 TVREDSGFFSCHAINSYG-----EDRGIIQLTVQEPPDPPEIEIKD--VKARTITLRWTM 737
Query: 1791 SEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSI-----NTTYQFRIYARNEI 1845
+G SPI Y +E K + W ++ +I ++TY R+YA+N I
Sbjct: 738 GF-DGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRI 796
Query: 1846 GTSLP 1850
G S P
Sbjct: 797 GKSEP 801
Score = 72.1 bits (169), Expect = 2e-11
Identities = 111/483 (22%), Positives = 188/483 (38%), Gaps = 39/483 (8%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP--DENISVAIE 685
+LE P + V + L C + P P I W + I+ IS I
Sbjct: 231 VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 290
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
S+ ++ S L I++ + G Y A N G +VL P I P+K++
Sbjct: 291 SEGNV-VSYLNISSSQVRDGGVYRCTANNSAG-----VVLYQARINVRGPASIRPMKNIT 344
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVY 803
G + +V+G P +I W KN+ P + + ++ + +K DEG Y
Sbjct: 345 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE-NNGTLKLSDVQKEVDEGEY 403
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
T ++ + +V +TV+ P P + F ++ ++ I V P+
Sbjct: 404 TCNVLVQPQLSTSQSVHVTVKVP------PFIQPFEFPRFSIGQRVFIPCVVVSGDLPI- 456
Query: 863 SITWYRNNEIISPSETIT-QNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
+ITW ++ I S +T N D + L I+N+ S + +G+Y C+A N A H +++
Sbjct: 457 TITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNL-SLMHNGNYTCIARNEAAAVEHQSQL 514
Query: 922 TIDVEKVTFVKHLQKSYETEEGKTVILECQT-SHTVSTKWYHNKKEISGMDHREIIQEGR 980
+ V V+ + + GK VIL C + V T + K + I GR
Sbjct: 515 IVRVPPKFVVQ--PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGR 572
Query: 981 XXXXXXXX-----XXXXDVGVIKCIVKDQ---ETSTMLVVKETIPEFIRKLQDFEV-KEK 1031
D G C V + + S + + IP I + + +
Sbjct: 573 IQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQG 632
Query: 1032 DVAILEVEINSETADVV-WERDGEIIKPKKNKY--DFEKRGH--IRKLYIRNTSVHDEGE 1086
+ + E +V WE++ II P+ +Y ++ G I L I T D G
Sbjct: 633 QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 692
Query: 1087 YSC 1089
+SC
Sbjct: 693 FSC 695
Score = 52.4 bits (120), Expect = 2e-05
Identities = 32/93 (34%), Positives = 51/93 (54%), Gaps = 6/93 (6%)
Query: 1964 TVPSPPTAP-LEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
TV PP P +EI+ V + + W T +DG +P+ GY+I ++ + + W +
Sbjct: 711 TVQEPPDPPEIEIKDVKARTITLRW-TMGFDGNSPITGYDIECKNKSDS-WDSAQRTKDV 768
Query: 2023 TLKFN---IRDLSENHTYMIRIYARNEIGLSEP 2052
+ + N I D+ + TY IR+YA+N IG SEP
Sbjct: 769 SPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEP 801
Score = 48.8 bits (111), Expect = 2e-04
Identities = 50/230 (21%), Positives = 87/230 (37%), Gaps = 14/230 (6%)
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIA 666
H T + ++ +PP F +P+ Q G ++L C P P I
Sbjct: 493 HNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIV 552
Query: 667 WLFKGEEIVPDENISVAIESDMHMYCS-VLKITNVKKFQEGTYTVVAVNREG-EASLPIV 724
W F VP +A+ + + + L I +V + G Y N G + S +
Sbjct: 553 WKFSKGAGVPQFQ-PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY 611
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK------AL 778
L +K P + + + QG+ +S G + W K ++ + +
Sbjct: 612 LTVKI----PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLV 667
Query: 779 PTKSDGDTHSITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
TK G+ T+ + P +D G ++ A NS G +TV+EP +
Sbjct: 668 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 717
Score = 48.4 bits (110), Expect = 3e-04
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 5/102 (4%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
S+ + AP ++ + G V+ C+ G+P P W + ++ S FQ
Sbjct: 48 SDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQK---- 103
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
V L+I + P D+G++ C N G A L V+ PL
Sbjct: 104 -TVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPL 144
Score = 47.2 bits (107), Expect = 6e-04
Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 5/111 (4%)
Query: 1854 DDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSW- 1912
+D+ I T+ P P + + +R++TL+WT +G SPIT Y IE K K SW
Sbjct: 703 EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWT-MGFDGNSPITGYDIECKN-KSDSWD 760
Query: 1913 --TKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
+ V ++ I +I R+ A+N +G S P+ ++ ++
Sbjct: 761 SAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADE 811
Score = 40.3 bits (90), Expect = 0.074
Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQDFQMYYDDDNVA-- 566
P FV + R + G V C EGYP P I W F + A + Q + ++
Sbjct: 520 PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG 579
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGF-ASSTTELIVEAP 603
+L+I+ V ED+G + C N G S + L V+ P
Sbjct: 580 SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP 617
Score = 39.5 bits (88), Expect = 0.13
Identities = 29/100 (29%), Positives = 37/100 (37%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQD--FQMYYDDDNVA 566
P + K V C V+G P P ITW I+K QM + NV
Sbjct: 237 PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 296
Query: 567 T-LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ L I D G + C A N+AG + V P S
Sbjct: 297 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 336
Score = 36.3 bits (80), Expect = 1.2
Identities = 17/78 (21%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V C V G +++W+R I+ P ++ ++ N L++ + D G + C
Sbjct: 158 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRI--TGINHENLIMDHMVKSDGGAYQC 215
Query: 584 VAKNAAGFASSTTELIVE 601
+ A ++++E
Sbjct: 216 FVRKDKLSAQDYVQVVLE 233
>AL583862-10|CAI14894.1| 1907|Homo sapiens protein tyrosine
phosphatase, receptor type, F protein.
Length = 1907
Score = 122 bits (295), Expect = 1e-26
Identities = 211/1018 (20%), Positives = 385/1018 (37%), Gaps = 98/1018 (9%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTID-GKKQKLK 1164
P I ++Q G A+F + T + + W K G ++ + D G L+
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLR 92
Query: 1165 IYDCDLD-DAGEYSCEVGNS----KCTAILTVEE--------PSINFTLRLPEFILVPAN 1211
I + D Y C NS +A L+V E PSI+ +L ++ A
Sbjct: 93 IQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLK--VVEKAR 150
Query: 1212 TDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLL 1271
T L + +++W+K ++ I ++ L I E DQ +Y CV
Sbjct: 151 TATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVAT 210
Query: 1272 DAKST-----TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
++ T L V V P+ + G V L P P +W++ ++
Sbjct: 211 NSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAE 270
Query: 1327 IIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK 1386
+ K + S ++ T I L G + VT+ P PP
Sbjct: 271 ELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL------GMIEATAQVTVKALPKPPID 324
Query: 1387 PNILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTT-EWISVKNITKTQTSIQNLK 1444
+ E ++S+ + WD +GNS + YY ++Y+ T + V + T+ SI L
Sbjct: 325 LVVTETTATSVTLTWD----SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLS 380
Query: 1445 TNSSYRFRAYAVNEVDISDASE-----TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDI 1499
S Y FR AVN + SE T E ++Q+ + + EP E+
Sbjct: 381 PFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEP 440
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXY--KCIAFNDHG 1557
G V +V + D ++ A + Y + +AF G
Sbjct: 441 N-----GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVG 495
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE-VIWYKNGN-KLEN 1615
+ S + ++ + + D Q D + + + +PP E +I Y+ E+
Sbjct: 496 DGPPSPTIQVKTQQGVPAQPADF-QAEVESDTRIQLSWL--LPPQERIIMYELVYWAAED 552
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP--- 1672
+ + + T + TS +++LK ++ + A + G T++ S P P
Sbjct: 553 EDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQK 612
Query: 1673 VIMREISRESVTIEW-KPPLDDGGLELTKYAIEKHEPD-NNRWIKVAD-VDRDVETYCIQ 1729
V+ + +V + W PP D +T+Y++ D +R V D + R+ ++ +
Sbjct: 613 VMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLV 672
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW- 1788
L + EY V A VG ES P++++T DVPS +++ +V++ W
Sbjct: 673 GLEKWTEYRVWVRAHTDVG--PGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWK 730
Query: 1789 --FPSEKNG------------------GSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQK 1828
PS+++G G PII ++ +W+ I
Sbjct: 731 LPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQ---DVMLAEAQWRPEESEDYETT-ISG 786
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
L+ TTY + A G S KI + T P +P ++S + + L+W
Sbjct: 787 LTPETTYSVTVAAYTTKGDGA--RSKPKI-VTTTGAVPGRP-TMMISTTAMNTALLQWHP 842
Query: 1889 PESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGV 1948
P+ G + Y +++ ++ + G + + + IFR++A+N G+
Sbjct: 843 PKELPGE-LLGYRLQYCRA-DEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL 900
Query: 1949 SLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW-DGGAPLLGYNIAIRD 2007
E + + +PS L + + ++ +W P + ++ Y + RD
Sbjct: 901 GEEFEKE---IRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 957
Query: 2008 VTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGE 2065
+ E+ + +T +F + L + TY I++ A G S PL + +P E
Sbjct: 958 INSQ--QELQNITTDT-RFTLTGLKPDTTYDIKVRAWTSKG-SGPLSPSIQSRTMPVE 1011
Score = 73.3 bits (172), Expect = 9e-12
Identities = 80/301 (26%), Positives = 127/301 (42%), Gaps = 29/301 (9%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P F K P+ Q G C+ P+P I W+ KG++ V + V IE D S
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKK-VSSQRFEV-IEFD-DGAGS 89
Query: 694 VLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQG 749
VL+I ++ + E Y A N GE + L + E+ P P + + +V +
Sbjct: 90 VLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKA 149
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYTL 805
+ + GNP P I+W K+ PV P S+G + ++ + D+G Y
Sbjct: 150 RTATMLCAAGGNPDPEISWFKDFLPVD--PATSNGRIKQLRSGALQIESSEESDQGKYEC 207
Query: 806 KAENSEGI---AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
A NS G A + + V + PP QE V G++ L P+P
Sbjct: 208 VATNSAGTRYSAPANLYVRVRRVAPRFSIPP----SSQE--VMPGGSVNLTCVAVGAPMP 261
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W E ++ + + G N+ L ++NV + S +Y CVA +S G A+VT
Sbjct: 262 YVKWMMGAEELTKEDEMPV---GRNV-LELSNV---VRSANYTCVAISSLGMIEATAQVT 314
Query: 923 I 923
+
Sbjct: 315 V 315
Score = 71.7 bits (168), Expect = 3e-11
Identities = 81/317 (25%), Positives = 130/317 (41%), Gaps = 36/317 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY-YDDDNVATL 568
P+F++ + G F CQ G P+P+ITW ++ + SQ F++ +DD + L
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVS-SQRFEVIEFDDGAGSVL 91
Query: 569 VIREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
I+ + D + C A N+ G E+ A LS E
Sbjct: 92 RIQPLRVQRDEAIYECTATNSLG------EINTSAKLSVLEEEQ---------------- 129
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ G P + P+ + V++ + C P+P+I+W FK V + I+
Sbjct: 130 LPPGFP-SIDMGPQLKVVEKARTATMLCAAGGNPDPEISW-FKDFLPVDPATSNGRIKQ- 186
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+ L+I + ++ +G Y VA N G S P L ++ P I P S V
Sbjct: 187 --LRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPP-SSQEV 243
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
G SV L+ VG P P + W + + TK D +L+ V YT
Sbjct: 244 MPGGSVNLTCVAVGAPMPYVKWMMGAEEL----TKEDEMPVGRNVLELSNVVRSANYTCV 299
Query: 807 AENSEGIAETSAVITVE 823
A +S G+ E +A +TV+
Sbjct: 300 AISSLGMIEATAQVTVK 316
Score = 64.5 bits (150), Expect = 4e-09
Identities = 62/254 (24%), Positives = 103/254 (40%), Gaps = 18/254 (7%)
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPSKPEGPVIM-REISRESVTIEWKPPLDDGGLELTKYA 1702
T+ A T G + V + P P +M + + ++W PP + G EL Y
Sbjct: 796 TVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPG-ELLGYR 854
Query: 1703 IEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT 1762
++ D R D +D + + + L++ Y+FR+ A+N G E E E I+T
Sbjct: 855 LQYCRADEAR-PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE---IRT 910
Query: 1763 ALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKVEIKQEGKKWKXXXXX 1819
D+PS + + + W P +E+NG II Y V + + +
Sbjct: 911 PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG--RIISYTVVFRDINSQQELQNIT 968
Query: 1820 XXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQ--PRNFVVSES 1877
+ L +TTY ++ A G+ P + +I P Q +NF V+ +
Sbjct: 969 TDTRFTLTGLKPDTTYDIKVRAWTSKGSG-PLSP----SIQSRTMPVEQVFAKNFRVAAA 1023
Query: 1878 TSRSVTLKWTEPES 1891
SV L W P+S
Sbjct: 1024 MKTSVLLSWEVPDS 1037
Score = 43.2 bits (97), Expect = 0.010
Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 10/107 (9%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FS P +Q V G + L C V P P + W+ EE+ E +M +
Sbjct: 230 VAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTK--------EDEMPVG 281
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
+VL+++NV + YT VA++ G + +K K P ++
Sbjct: 282 RNVLELSNV--VRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLV 326
>U72391-1|AAC51287.1| 1461|Homo sapiens neogenin protein.
Length = 1461
Score = 122 bits (294), Expect = 1e-26
Identities = 134/576 (23%), Positives = 226/576 (39%), Gaps = 37/576 (6%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
+D+ L C+ G+P P + W ++ + L T + Y CIA
Sbjct: 264 QDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD 323
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKL 1613
N + +E + +Q +P +I + + + + G P P V W KNG+ +
Sbjct: 324 NGNETIEAQAELTVQAQPEFLKQPTNIYAHESM--DIVFECEVTGKPTPTVKWVKNGDMV 381
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP- 1672
+ I + V+ L +S Y A N G + L + + GP
Sbjct: 382 IPSDYFKIVKEHNLQVL---GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPL 438
Query: 1673 ------VIMREISRESVTIEWKPPLDD-GGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
V+ +S + + W+ P D G LT E ++ +++
Sbjct: 439 PSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQV 498
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP-SXXXXXXXXXXIDNESV 1784
IQ L Y+FRV+AQN G E+ S P+ ++T +V S+
Sbjct: 499 -TIQNLMPATVYIFRVMAQNKHGSGES--SAPLRVETQPEVQLPGPAPNLRAYAASPTSI 555
Query: 1785 YITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNE 1844
+TW + +G I +YK+ ++G + I L T Y FR+ A N+
Sbjct: 556 TVTW-ETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNK 614
Query: 1845 IGTSLPYTSDDKITIGKTLT--PPSQPRNFVVSESTSRSVTLKWTEP-ESNGGSPITNYI 1901
G P S + + +TL+ P + P+N + S+S+ + W P + IT Y
Sbjct: 615 HG---PGVSTPDVAV-RTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
I ++ KS V G+ IE + E FR++A G T+ S +
Sbjct: 671 IRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFE 730
Query: 1962 ----HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
VP P++ L +R + ++IV+ SW PE + + GY AI + +
Sbjct: 731 SDLDETRVPEVPSS-LHVRPLVTSIVV-SWTPPE-NQNIVVRGY--AIGYGIGSPHAQTI 785
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
KVD + I +L + Y+I + A N +G PL
Sbjct: 786 KVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPL 821
Score = 86.2 bits (204), Expect = 1e-15
Identities = 208/1008 (20%), Positives = 359/1008 (35%), Gaps = 106/1008 (10%)
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNT--SVH---DEGEYS 1088
IL SE + + W++DG + + D + L+I N S H DEG Y
Sbjct: 71 ILNCSAYSEPSPKIEWKKDGTFLNLVSD--DRRQLLPDGSLFISNVVHSKHNKPDEGYYQ 128
Query: 1089 CILRDESC------TAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFK 1141
C+ ES TA++ V LP ++ + V GN A E+ VRW +
Sbjct: 129 CVATVESLGTIISRTAKLIVAGLP-RFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQ 187
Query: 1142 DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN------SKCTAILTVEEPS 1195
+ + + + G L I + D G Y C V + S + + +P
Sbjct: 188 NRQPLLLDDRVIKLPSGM---LVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPE 244
Query: 1196 INFTL---RLPEFILVPANTDAYLT-VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKR 1251
+ L + P ++ D L V T + W K + + DTE + +
Sbjct: 245 VISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEAL-DTESSERLVLLAGG 303
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVD 1310
+L I TEDD Y C+ + T + + E+ V+ P+ + D+ +
Sbjct: 304 SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECE 363
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD 1370
P P +W+ N ++ + K K +L + + +D G Y+ EN+ G+A
Sbjct: 364 VTGKPTPTVKWVKNGDMVIPSDYFKIV---KEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
Query: 1371 VEMNVTILDK--------PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI 1422
+ IL+ PS P + + I + W P + + + Y V Y
Sbjct: 421 AGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFY--- 477
Query: 1423 DTTEWISVKNITKT------QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
T E I+ + + T Q +IQNL + Y FR A N+ + E++ +V +
Sbjct: 478 -TKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNK---HGSGESSAPLRVETQ 533
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIEL--TCIFGGVPQPKVTWYRDGKKLKTAKATYENRXX 1534
++Q P L+ P T + G Y K + +
Sbjct: 534 PEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHS 593
Query: 1535 XXXXXXXXXXXXXYKCIAFNDHGE-VETS--CVVGIQQKPVITISN--EDIKQKHKVGDE 1589
++ +A+N HG V T V + P N +++ +
Sbjct: 594 YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIH 653
Query: 1590 WL--VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
W A G I Y+ ++ + E ++ + + + I+ L R + + A
Sbjct: 654 WQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQL--IEGLDRGTEYNFRVAA 711
Query: 1648 SNTAGTS------SVEVTLKVYDKPSKPEGPVIMR-EISRESVTIEWKPPLDDGGLELTK 1700
GT S E D+ PE P + S+ + W PP ++ + +
Sbjct: 712 LTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPP-ENQNIVVRG 770
Query: 1701 YAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVG----FSEALESE 1756
YAI + + VD Y I+ L+ + Y+ + A N VG E+ +
Sbjct: 771 YAI--GYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTR 828
Query: 1757 PIVIKTALDV--------------PSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIID- 1801
P + +D+ P + ++++ ITW + I D
Sbjct: 829 PHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDS 888
Query: 1802 --YKVEIKQE---GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDK 1856
Y V K K+K + L NT Y+F + +S +
Sbjct: 889 RYYTVRWKTNIPANTKYKNANATTLSYL-VTGLKPNTLYEFSVMVTKGRRSSTWSMTAHG 947
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT---VKGKSWT 1913
T T P + V E +++ + W +P S IT YII + T + W
Sbjct: 948 TTFELVPTSPPKDVTVVSKEGKPKTIIVNW-QPPSEANGKITGYIIYYSTDVNAEIHDWV 1006
Query: 1914 KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
I V G+ H I+ + F+I A N+ G+ +E+ R K
Sbjct: 1007 -IEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK 1053
Score = 81.8 bits (193), Expect = 2e-14
Identities = 102/468 (21%), Positives = 183/468 (39%), Gaps = 28/468 (5%)
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
+G + ++ V G+P P + W KN L+ + + S + I ++ + Y
Sbjct: 262 IGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGS-LEISDVTEDDAGTYFC 320
Query: 1646 EASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEK 1705
A N T + L V +P + P + + ES+ I ++ + K+
Sbjct: 321 IADNGNETIEAQAELTVQAQPEFLKQPTNI--YAHESMDIVFECEVTGKPTPTVKWV--- 375
Query: 1706 HEPDNNRWIKVADVDRDVETYCIQKLN--ENCEYMFRVIAQNPVGFSEALESEPIVIK-- 1761
N + +D + V+ + +Q L ++ E ++ IA+N VG ++A ++ I+++
Sbjct: 376 ---KNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQA-GAQLIILEHA 431
Query: 1762 --TALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG---KKWKXX 1816
T +PS + + +TW + + Y V +EG ++ +
Sbjct: 432 PATTGPLPSAPRDVVASL-VSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENT 490
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE 1876
IQ L T Y FR+ A+N+ G+ ++ ++ + P N
Sbjct: 491 SHPGEMQVTIQNLMPATVYIFRVMAQNKHGSG-ESSAPLRVETQPEVQLPGPAPNLRAYA 549
Query: 1877 STSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEI 1936
++ S+T+ W P S G I NY + + KG + V V S H + I +K+ E
Sbjct: 550 ASPTSITVTWETPVSGNGE-IQNYKLYYME-KGTDKEQDVDV--SSHSYTINGLKKYTEY 605
Query: 1937 IFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP-EWDGG 1995
FR+ A N G + T +VR +P LE+R S +M W P
Sbjct: 606 SFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVR--NSKSIMIHWQPPAPATQN 663
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
+ GY I R ++ + V L I L Y R+ A
Sbjct: 664 GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711
Score = 79.0 bits (186), Expect = 2e-13
Identities = 85/306 (27%), Positives = 137/306 (44%), Gaps = 35/306 (11%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
I+ G+P F+ +P+ V G++ +L C + A P + W + ++ D+ + + + S
Sbjct: 147 IVAGLP-RFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRV-IKLPSG 204
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL-----K 742
M L I+N + G Y V V G +++K P+VI L
Sbjct: 205 M------LVISNATEGDGGLYRCV-VESGGPPKYSDEVELKV--LPDPEVISDLVFLKQP 255
Query: 743 SMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT--ILKPKKVK- 798
S +VR G+ V+L G P PTI W KN + AL T+S + L+ V
Sbjct: 256 SPLVRVIGQDVVLPCVASGLPTPTIKWMKNEE---ALDTESSERLVLLAGGSLEISDVTE 312
Query: 799 -DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y A+N E A +TV+ A+P F+ + I E I VT
Sbjct: 313 DDAGTYFCIADNGNETIEAQAELTVQ------AQPE-FLKQPTNIYAHESMDIVFECEVT 365
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P++ W +N +++ PS+ + N++ V+ V S D G Y+C+A N G +
Sbjct: 366 GKPTPTVKWVKNGDMVIPSDYF-KIVKEHNLQ-VLGLVKS--DEGFYQCIAENDVGNAQA 421
Query: 918 GARVTI 923
GA++ I
Sbjct: 422 GAQLII 427
Score = 68.1 bits (159), Expect = 3e-10
Identities = 91/384 (23%), Positives = 157/384 (40%), Gaps = 40/384 (10%)
Query: 737 VIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-----SDGDTHSITI 791
++EP+ ++ VR G SVIL+ P P I W K+ + + DG +
Sbjct: 56 LVEPVDTLSVR-GSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
Query: 792 LKPKKVK-DEGVYTLKA--ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+ K K DEG Y A E+ I +A + V A P F ++ + +V
Sbjct: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV-------AGLPRFTSQPEPSSVYAGN 167
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVA 908
L V + VP + W +N + + + + + G LVI+N +E D G Y+CV
Sbjct: 168 NAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSG---MLVISNA-TEGDGGLYRCVV 223
Query: 909 SNSAGKSSHGARVTI----DVEKVTFVKHLQKSYETEE--GKTVILECQTS--HTVSTKW 960
S G + V + D E ++ + L++ G+ V+L C S T + KW
Sbjct: 224 -ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKW 282
Query: 961 YHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI--- 1016
N++ + + R ++ G D G CI + + + T+
Sbjct: 283 MKNEEALDTESSERLVLLAG--GSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQ 340
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
PEF+++ + E + E E+ + T V W ++G+++ P D+ K L
Sbjct: 341 PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPS----DYFKIVKEHNLQ 396
Query: 1076 IRNTSVHDEGEYSCILRDESCTAE 1099
+ DEG Y CI ++ A+
Sbjct: 397 VLGLVKSDEGFYQCIAENDVGNAQ 420
Score = 65.7 bits (153), Expect = 2e-09
Identities = 52/197 (26%), Positives = 87/197 (44%), Gaps = 10/197 (5%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F K+P G D++L C +P P I W+ K EE + E+ E + + L
Sbjct: 251 FLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWM-KNEEALDTESS----ERLVLLAGGSL 305
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
+I++V + GTY +A N G ++ ++ T + +P + +P ++ + ++
Sbjct: 306 EISDVTEDDAGTYFCIADN--GNETIEAQAEL-TVQAQPEFLKQPT-NIYAHESMDIVFE 361
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
+V G P PT+ W KN V H++ +L K DEG Y AEN G A+
Sbjct: 362 CEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVK-SDEGFYQCIAENDVGNAQ 420
Query: 816 TSAVITVEEPTEENAEP 832
A + + E P
Sbjct: 421 AGAQLIILEHAPATTGP 437
Score = 64.1 bits (149), Expect = 5e-09
Identities = 87/402 (21%), Positives = 151/402 (37%), Gaps = 24/402 (5%)
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVA 683
A I P F +P GS ++L C + P P I W G +V D+ +
Sbjct: 45 ASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL 104
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS 743
D ++ S + + K EG Y VA + K+ P+ +
Sbjct: 105 --PDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL--PRFTSQPEP 160
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVY 803
V G + IL+ +V + P + W +N +P+ L + + ++ D G+Y
Sbjct: 161 SSVYAGNNAILNCEVNADLVPFVRWEQNRQPL-LLDDRVIKLPSGMLVISNATEGDGGLY 219
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
E+ + V P E +F+ + + + L + P P+
Sbjct: 220 RCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPT 279
Query: 864 ITWYRNNEII--SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
I W +N E + SE + G L I++V +E D+G Y C+A N A +
Sbjct: 280 IKWMKNEEALDTESSERLVLLAGG---SLEISDV-TEDDAGTYFCIADNGNETIEAQAEL 335
Query: 922 TIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEG 979
T+ + F+K Y E ++ EC+ + T + KW N + D+ +I++E
Sbjct: 336 TVQAQP-EFLKQPTNIY-AHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKE- 392
Query: 980 RXXXXXXXXXXXXDVGVIKCI----VKDQETSTMLVVKETIP 1017
D G +CI V + + L++ E P
Sbjct: 393 --HNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAP 432
Score = 46.8 bits (106), Expect = 9e-04
Identities = 23/91 (25%), Positives = 46/91 (50%), Gaps = 4/91 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++ + + + FEC+V G P P + W + ++ PS F++ + + L
Sbjct: 341 PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN----LQ 396
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ + D G + C+A+N G A + +LI+
Sbjct: 397 VLGLVKSDEGFYQCIAENDVGNAQAGAQLII 427
Score = 40.3 bits (90), Expect = 0.074
Identities = 24/92 (26%), Positives = 39/92 (42%), Gaps = 2/92 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F+++ P G V C G P P I W + + ++ +L I
Sbjct: 250 VFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG--SLEI 307
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+V +DAGT+ C+A N + EL V+A
Sbjct: 308 SDVTEDDAGTYFCIADNGNETIEAQAELTVQA 339
>U61262-1|AAB17263.1| 1461|Homo sapiens neogenin protein.
Length = 1461
Score = 122 bits (294), Expect = 1e-26
Identities = 134/576 (23%), Positives = 226/576 (39%), Gaps = 37/576 (6%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
+D+ L C+ G+P P + W ++ + L T + Y CIA
Sbjct: 264 QDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD 323
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKL 1613
N + +E + +Q +P +I + + + + G P P V W KNG+ +
Sbjct: 324 NGNETIEAQAELTVQAQPEFLKQPTNIYAHESM--DIVFECEVTGKPTPTVKWVKNGDMV 381
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP- 1672
+ I + V+ L +S Y A N G + L + + GP
Sbjct: 382 IPSDYFKIVKEHNLQVL---GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPL 438
Query: 1673 ------VIMREISRESVTIEWKPPLDD-GGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
V+ +S + + W+ P D G LT E ++ +++
Sbjct: 439 PSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQV 498
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP-SXXXXXXXXXXIDNESV 1784
IQ L Y+FRV+AQN G E+ S P+ ++T +V S+
Sbjct: 499 -TIQNLMPATVYIFRVMAQNKHGSGES--SAPLRVETQPEVQLPGPAPNLRAYAASPTSI 555
Query: 1785 YITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNE 1844
+TW + +G I +YK+ ++G + I L T Y FR+ A N+
Sbjct: 556 TVTW-ETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNK 614
Query: 1845 IGTSLPYTSDDKITIGKTLT--PPSQPRNFVVSESTSRSVTLKWTEP-ESNGGSPITNYI 1901
G P S + + +TL+ P + P+N + S+S+ + W P + IT Y
Sbjct: 615 HG---PGVSTPDVAV-RTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
I ++ KS V G+ IE + E FR++A G T+ S +
Sbjct: 671 IRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFE 730
Query: 1962 ----HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
VP P++ L +R + ++IV+ SW PE + + GY AI + +
Sbjct: 731 SDLDETRVPEVPSS-LHVRPLVTSIVV-SWTPPE-NQNIVVRGY--AIGYGIGSPHAQTI 785
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
KVD + I +L + Y+I + A N +G PL
Sbjct: 786 KVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPL 821
Score = 85.4 bits (202), Expect = 2e-15
Identities = 208/1008 (20%), Positives = 359/1008 (35%), Gaps = 106/1008 (10%)
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNT--SVH---DEGEYS 1088
IL SE + + W++DG + + D + L+I N S H DEG Y
Sbjct: 71 ILNCSAYSEPSPKIEWKKDGTFLNLVSD--DRRQLLPDGSLFISNVVHSKHNKPDEGYYQ 128
Query: 1089 CILRDESC------TAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFK 1141
C+ ES TA++ V LP ++ + V GN A E+ VRW +
Sbjct: 129 CVATVESLGTIISRTAKLIVAGLP-RFTSQPEPSSVYAGNGAILNCEVNADLVPFVRWEQ 187
Query: 1142 DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN------SKCTAILTVEEPS 1195
+ + + + G L I + D G Y C V + S + + +P
Sbjct: 188 NRQPLLLDDRVIKLPSGM---LVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPE 244
Query: 1196 INFTL---RLPEFILVPANTDAYLT-VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKR 1251
+ L + P ++ D L V T + W K + + DTE + +
Sbjct: 245 VISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEAL-DTESSERLVLLAGG 303
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVD 1310
+L I TEDD Y C+ + T + + E+ V+ P+ + D+ +
Sbjct: 304 SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECE 363
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD 1370
P P +W+ N ++ + K K +L + + +D G Y+ EN+ G+A
Sbjct: 364 VTGKPTPTVKWVKNGDMVIPSDYFKIV---KEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
Query: 1371 VEMNVTILDK--------PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI 1422
+ IL+ PS P + + I + W P + + + Y V Y
Sbjct: 421 AGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFY--- 477
Query: 1423 DTTEWISVKNITKT------QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
T E I+ + + T Q +IQNL + Y FR A N+ + E++ +V +
Sbjct: 478 -TKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNK---HGSGESSAPLRVETQ 533
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIEL--TCIFGGVPQPKVTWYRDGKKLKTAKATYENRXX 1534
++Q P L+ P T + G Y K + +
Sbjct: 534 PEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHS 593
Query: 1535 XXXXXXXXXXXXXYKCIAFNDHGE-VETS--CVVGIQQKPVITISN--EDIKQKHKVGDE 1589
++ +A+N HG V T V + P N +++ +
Sbjct: 594 YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIH 653
Query: 1590 WL--VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
W A G I Y+ ++ + E ++ + + + I+ L R + + A
Sbjct: 654 WQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQL--IEGLDRGTEYNFRVAA 711
Query: 1648 SNTAGTS------SVEVTLKVYDKPSKPEGPVIMR-EISRESVTIEWKPPLDDGGLELTK 1700
GT S E D+ PE P + S+ + W PP ++ + +
Sbjct: 712 LTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPP-ENQNIVVRG 770
Query: 1701 YAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVG----FSEALESE 1756
YAI + + VD Y I+ L+ + Y+ + A N VG E+ +
Sbjct: 771 YAI--GYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTR 828
Query: 1757 PIVIKTALDV--------------PSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIID- 1801
P + +D+ P + ++++ ITW + I D
Sbjct: 829 PHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDS 888
Query: 1802 --YKVEIKQE---GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDK 1856
Y V K K+K + L NT Y+F + +S +
Sbjct: 889 RYYTVRWKTNIPANTKYKNANATTLSYL-VTGLKPNTLYEFSVMVTKGRRSSTWSMTAHG 947
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT---VKGKSWT 1913
T T P + V E +++ + W +P S IT YII + T + W
Sbjct: 948 TTFELVPTSPPKDVTVVSKEGKPKTIIVNW-QPPSEANGKITGYIIYYSTDVNAEIHDWV 1006
Query: 1914 KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
I V G+ H I+ + F+I A N+ G+ +E+ R K
Sbjct: 1007 -IEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK 1053
Score = 81.8 bits (193), Expect = 2e-14
Identities = 102/468 (21%), Positives = 183/468 (39%), Gaps = 28/468 (5%)
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
+G + ++ V G+P P + W KN L+ + + S + I ++ + Y
Sbjct: 262 IGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGS-LEISDVTEDDAGTYFC 320
Query: 1646 EASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEK 1705
A N T + L V +P + P + + ES+ I ++ + K+
Sbjct: 321 IADNGNETIEAQAELTVQAQPEFLKQPTNI--YAHESMDIVFECEVTGKPTPTVKWV--- 375
Query: 1706 HEPDNNRWIKVADVDRDVETYCIQKLN--ENCEYMFRVIAQNPVGFSEALESEPIVIK-- 1761
N + +D + V+ + +Q L ++ E ++ IA+N VG ++A ++ I+++
Sbjct: 376 ---KNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQA-GAQLIILEHA 431
Query: 1762 --TALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG---KKWKXX 1816
T +PS + + +TW + + Y V +EG ++ +
Sbjct: 432 PATTGPLPSAPRDVVASL-VSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENT 490
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE 1876
IQ L T Y FR+ A+N+ G+ ++ ++ + P N
Sbjct: 491 SHPGEMQVTIQNLMPATVYIFRVMAQNKHGSG-ESSAPLRVETQPEVQLPGPAPNLRAYA 549
Query: 1877 STSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEI 1936
++ S+T+ W P S G I NY + + KG + V V S H + I +K+ E
Sbjct: 550 ASPTSITVTWETPVSGNGE-IQNYKLYYME-KGTDKEQDVDV--SSHSYTINGLKKYTEY 605
Query: 1937 IFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP-EWDGG 1995
FR+ A N G + T +VR +P LE+R S +M W P
Sbjct: 606 SFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVR--NSKSIMIHWQPPAPATQN 663
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
+ GY I R ++ + V L I L Y R+ A
Sbjct: 664 GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711
Score = 78.2 bits (184), Expect = 3e-13
Identities = 85/306 (27%), Positives = 136/306 (44%), Gaps = 35/306 (11%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
I+ G+P F+ +P+ V G+ +L C + A P + W + ++ D+ + + + S
Sbjct: 147 IVAGLP-RFTSQPEPSSVYAGNGAILNCEVNADLVPFVRWEQNRQPLLLDDRV-IKLPSG 204
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL-----K 742
M L I+N + G Y V V G +++K P+VI L
Sbjct: 205 M------LVISNATEGDGGLYRCV-VESGGPPKYSDEVELKV--LPDPEVISDLVFLKQP 255
Query: 743 SMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT--ILKPKKVK- 798
S +VR G+ V+L G P PTI W KN + AL T+S + L+ V
Sbjct: 256 SPLVRVIGQDVVLPCVASGLPTPTIKWMKNEE---ALDTESSERLVLLAGGSLEISDVTE 312
Query: 799 -DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y A+N E A +TV+ A+P F+ + I E I VT
Sbjct: 313 DDAGTYFCIADNGNETIEAQAELTVQ------AQPE-FLKQPTNIYAHESMDIVFECEVT 365
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P++ W +N +++ PS+ + N++ V+ V S D G Y+C+A N G +
Sbjct: 366 GKPTPTVKWVKNGDMVIPSDYF-KIVKEHNLQ-VLGLVKS--DEGFYQCIAENDVGNAQA 421
Query: 918 GARVTI 923
GA++ I
Sbjct: 422 GAQLII 427
Score = 67.3 bits (157), Expect = 6e-10
Identities = 91/384 (23%), Positives = 157/384 (40%), Gaps = 40/384 (10%)
Query: 737 VIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-----SDGDTHSITI 791
++EP+ ++ VR G SVIL+ P P I W K+ + + DG +
Sbjct: 56 LVEPVDTLSVR-GSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
Query: 792 LKPKKVK-DEGVYTLKA--ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+ K K DEG Y A E+ I +A + V A P F ++ + +V
Sbjct: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV-------AGLPRFTSQPEPSSVYAGN 167
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVA 908
L V + VP + W +N + + + + + G LVI+N +E D G Y+CV
Sbjct: 168 GAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSG---MLVISNA-TEGDGGLYRCVV 223
Query: 909 SNSAGKSSHGARVTI----DVEKVTFVKHLQKSYETEE--GKTVILECQTS--HTVSTKW 960
S G + V + D E ++ + L++ G+ V+L C S T + KW
Sbjct: 224 -ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKW 282
Query: 961 YHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI--- 1016
N++ + + R ++ G D G CI + + + T+
Sbjct: 283 MKNEEALDTESSERLVLLAG--GSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQ 340
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
PEF+++ + E + E E+ + T V W ++G+++ P D+ K L
Sbjct: 341 PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPS----DYFKIVKEHNLQ 396
Query: 1076 IRNTSVHDEGEYSCILRDESCTAE 1099
+ DEG Y CI ++ A+
Sbjct: 397 VLGLVKSDEGFYQCIAENDVGNAQ 420
Score = 65.7 bits (153), Expect = 2e-09
Identities = 52/197 (26%), Positives = 87/197 (44%), Gaps = 10/197 (5%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F K+P G D++L C +P P I W+ K EE + E+ E + + L
Sbjct: 251 FLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWM-KNEEALDTESS----ERLVLLAGGSL 305
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
+I++V + GTY +A N G ++ ++ T + +P + +P ++ + ++
Sbjct: 306 EISDVTEDDAGTYFCIADN--GNETIEAQAEL-TVQAQPEFLKQPT-NIYAHESMDIVFE 361
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
+V G P PT+ W KN V H++ +L K DEG Y AEN G A+
Sbjct: 362 CEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVK-SDEGFYQCIAENDVGNAQ 420
Query: 816 TSAVITVEEPTEENAEP 832
A + + E P
Sbjct: 421 AGAQLIILEHAPATTGP 437
Score = 63.7 bits (148), Expect = 7e-09
Identities = 87/402 (21%), Positives = 150/402 (37%), Gaps = 24/402 (5%)
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVA 683
A I P F +P GS ++L C + P P I W G +V D+ +
Sbjct: 45 ASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL 104
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS 743
D ++ S + + K EG Y VA + K+ P+ +
Sbjct: 105 --PDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL--PRFTSQPEP 160
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVY 803
V G IL+ +V + P + W +N +P+ L + + ++ D G+Y
Sbjct: 161 SSVYAGNGAILNCEVNADLVPFVRWEQNRQPL-LLDDRVIKLPSGMLVISNATEGDGGLY 219
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
E+ + V P E +F+ + + + L + P P+
Sbjct: 220 RCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPT 279
Query: 864 ITWYRNNEII--SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
I W +N E + SE + G L I++V +E D+G Y C+A N A +
Sbjct: 280 IKWMKNEEALDTESSERLVLLAGG---SLEISDV-TEDDAGTYFCIADNGNETIEAQAEL 335
Query: 922 TIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEG 979
T+ + F+K Y E ++ EC+ + T + KW N + D+ +I++E
Sbjct: 336 TVQAQP-EFLKQPTNIY-AHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKE- 392
Query: 980 RXXXXXXXXXXXXDVGVIKCI----VKDQETSTMLVVKETIP 1017
D G +CI V + + L++ E P
Sbjct: 393 --HNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAP 432
Score = 46.8 bits (106), Expect = 9e-04
Identities = 23/91 (25%), Positives = 46/91 (50%), Gaps = 4/91 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++ + + + FEC+V G P P + W + ++ PS F++ + + L
Sbjct: 341 PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN----LQ 396
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ + D G + C+A+N G A + +LI+
Sbjct: 397 VLGLVKSDEGFYQCIAENDVGNAQAGAQLII 427
Score = 40.3 bits (90), Expect = 0.074
Identities = 24/92 (26%), Positives = 39/92 (42%), Gaps = 2/92 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F+++ P G V C G P P I W + + ++ +L I
Sbjct: 250 VFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG--SLEI 307
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+V +DAGT+ C+A N + EL V+A
Sbjct: 308 SDVTEDDAGTYFCIADNGNETIEAQAELTVQA 339
>BC117161-1|AAI17162.1| 1461|Homo sapiens neogenin homolog 1 (chicken)
protein.
Length = 1461
Score = 122 bits (294), Expect = 1e-26
Identities = 134/576 (23%), Positives = 226/576 (39%), Gaps = 37/576 (6%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKT---AKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
+D+ L C+ G+P P + W ++ + L T + Y CIA
Sbjct: 264 QDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD 323
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKL 1613
N + +E + +Q +P +I + + + + G P P V W KNG+ +
Sbjct: 324 NGNETIEAQAELTVQAQPEFLKQPTNIYAHESM--DIVFECEVTGKPTPTVKWVKNGDMV 381
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP- 1672
+ I + V+ L +S Y A N G + L + + GP
Sbjct: 382 IPSDYFKIVKEHNLQVL---GLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPL 438
Query: 1673 ------VIMREISRESVTIEWKPPLDD-GGLELTKYAIEKHEPDNNRWIKVADVDRDVET 1725
V+ +S + + W+ P D G LT E ++ +++
Sbjct: 439 PSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQV 498
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP-SXXXXXXXXXXIDNESV 1784
IQ L Y+FRV+AQN G E+ S P+ ++T +V S+
Sbjct: 499 -TIQNLMPATVYIFRVMAQNKHGSGES--SAPLRVETQPEVQLPGPAPNLRAYAASPTSI 555
Query: 1785 YITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNE 1844
+TW + +G I +YK+ ++G + I L T Y FR+ A N+
Sbjct: 556 TVTW-ETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNK 614
Query: 1845 IGTSLPYTSDDKITIGKTLT--PPSQPRNFVVSESTSRSVTLKWTEP-ESNGGSPITNYI 1901
G P S + + +TL+ P + P+N + S+S+ + W P + IT Y
Sbjct: 615 HG---PGVSTPDVAV-RTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYK 670
Query: 1902 IEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
I ++ KS V G+ IE + E FR++A G T+ S +
Sbjct: 671 IRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFE 730
Query: 1962 ----HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
VP P++ L +R + ++IV+ SW PE + + GY AI + +
Sbjct: 731 SDLDETRVPEVPSS-LHVRPLVTSIVV-SWTPPE-NQNIVVRGY--AIGYGIGSPHAQTI 785
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
KVD + I +L + Y+I + A N +G PL
Sbjct: 786 KVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPL 821
Score = 86.2 bits (204), Expect = 1e-15
Identities = 208/1008 (20%), Positives = 359/1008 (35%), Gaps = 106/1008 (10%)
Query: 1035 ILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNT--SVH---DEGEYS 1088
IL SE + + W++DG + + D + L+I N S H DEG Y
Sbjct: 71 ILNCSAYSEPSPKIEWKKDGTFLNLVSD--DRRQLLPDGSLFISNVVHSKHNKPDEGYYQ 128
Query: 1089 CILRDESC------TAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA-LVRWFK 1141
C+ ES TA++ V LP ++ + V GN A E+ VRW +
Sbjct: 129 CVATVESLGTIISRTAKLIVAGLP-RFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQ 187
Query: 1142 DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN------SKCTAILTVEEPS 1195
+ + + + G L I + D G Y C V + S + + +P
Sbjct: 188 NRQPLLLDDRVIKLPSGM---LVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPE 244
Query: 1196 INFTL---RLPEFILVPANTDAYLT-VEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKR 1251
+ L + P ++ D L V T + W K + + DTE + +
Sbjct: 245 VISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEAL-DTESSERLVLLAGG 303
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVD 1310
+L I TEDD Y C+ + T + + E+ V+ P+ + D+ +
Sbjct: 304 SLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECE 363
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD 1370
P P +W+ N ++ + K K +L + + +D G Y+ EN+ G+A
Sbjct: 364 VTGKPTPTVKWVKNGDMVIPSDYFKIV---KEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
Query: 1371 VEMNVTILDK--------PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI 1422
+ IL+ PS P + + I + W P + + + Y V Y
Sbjct: 421 AGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFY--- 477
Query: 1423 DTTEWISVKNITKT------QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
T E I+ + + T Q +IQNL + Y FR A N+ + E++ +V +
Sbjct: 478 -TKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNK---HGSGESSAPLRVETQ 533
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIEL--TCIFGGVPQPKVTWYRDGKKLKTAKATYENRXX 1534
++Q P L+ P T + G Y K + +
Sbjct: 534 PEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHS 593
Query: 1535 XXXXXXXXXXXXXYKCIAFNDHGE-VETS--CVVGIQQKPVITISN--EDIKQKHKVGDE 1589
++ +A+N HG V T V + P N +++ +
Sbjct: 594 YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIH 653
Query: 1590 WL--VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
W A G I Y+ ++ + E ++ + + + I+ L R + + A
Sbjct: 654 WQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQL--IEGLDRGTEYNFRVAA 711
Query: 1648 SNTAGTS------SVEVTLKVYDKPSKPEGPVIMR-EISRESVTIEWKPPLDDGGLELTK 1700
GT S E D+ PE P + S+ + W PP ++ + +
Sbjct: 712 LTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPP-ENQNIVVRG 770
Query: 1701 YAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVG----FSEALESE 1756
YAI + + VD Y I+ L+ + Y+ + A N VG E+ +
Sbjct: 771 YAI--GYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTR 828
Query: 1757 PIVIKTALDV--------------PSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIID- 1801
P + +D+ P + ++++ ITW + I D
Sbjct: 829 PHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDS 888
Query: 1802 --YKVEIKQE---GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDK 1856
Y V K K+K + L NT Y+F + +S +
Sbjct: 889 RYYTVRWKTNIPANTKYKNANATTLSYL-VTGLKPNTLYEFSVMVTKGRRSSTWSMTAHG 947
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT---VKGKSWT 1913
T T P + V E +++ + W +P S IT YII + T + W
Sbjct: 948 TTFELVPTSPPKDVTVVSKEGKPKTIIVNW-QPPSEANGKITGYIIYYSTDVNAEIHDWV 1006
Query: 1914 KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEK 1961
I V G+ H I+ + F+I A N+ G+ +E+ R K
Sbjct: 1007 -IEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK 1053
Score = 81.8 bits (193), Expect = 2e-14
Identities = 102/468 (21%), Positives = 183/468 (39%), Gaps = 28/468 (5%)
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
+G + ++ V G+P P + W KN L+ + + S + I ++ + Y
Sbjct: 262 IGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGS-LEISDVTEDDAGTYFC 320
Query: 1646 EASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEK 1705
A N T + L V +P + P + + ES+ I ++ + K+
Sbjct: 321 IADNGNETIEAQAELTVQAQPEFLKQPTNI--YAHESMDIVFECEVTGKPTPTVKWV--- 375
Query: 1706 HEPDNNRWIKVADVDRDVETYCIQKLN--ENCEYMFRVIAQNPVGFSEALESEPIVIK-- 1761
N + +D + V+ + +Q L ++ E ++ IA+N VG ++A ++ I+++
Sbjct: 376 ---KNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQA-GAQLIILEHA 431
Query: 1762 --TALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG---KKWKXX 1816
T +PS + + +TW + + Y V +EG ++ +
Sbjct: 432 PATTGPLPSAPRDVVASL-VSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENT 490
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSE 1876
IQ L T Y FR+ A+N+ G+ ++ ++ + P N
Sbjct: 491 SHPGEMQVTIQNLMPATVYIFRVMAQNKHGSG-ESSAPLRVETQPEVQLPGPAPNLRAYA 549
Query: 1877 STSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEI 1936
++ S+T+ W P S G I NY + + KG + V V S H + I +K+ E
Sbjct: 550 ASPTSITVTWETPVSGNGE-IQNYKLYYME-KGTDKEQDVDV--SSHSYTINGLKKYTEY 605
Query: 1937 IFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP-EWDGG 1995
FR+ A N G + T +VR +P LE+R S +M W P
Sbjct: 606 SFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVR--NSKSIMIHWQPPAPATQN 663
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
+ GY I R ++ + V L I L Y R+ A
Sbjct: 664 GQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAA 711
Score = 79.0 bits (186), Expect = 2e-13
Identities = 85/306 (27%), Positives = 137/306 (44%), Gaps = 35/306 (11%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
I+ G+P F+ +P+ V G++ +L C + A P + W + ++ D+ + + + S
Sbjct: 147 IVAGLP-RFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRV-IKLPSG 204
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL-----K 742
M L I+N + G Y V V G +++K P+VI L
Sbjct: 205 M------LVISNATEGDGGLYRCV-VESGGPPKYSDEVELKV--LPDPEVISDLVFLKQP 255
Query: 743 SMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT--ILKPKKVK- 798
S +VR G+ V+L G P PTI W KN + AL T+S + L+ V
Sbjct: 256 SPLVRVIGQDVVLPCVASGLPTPTIKWMKNEE---ALDTESSERLVLLAGGSLEISDVTE 312
Query: 799 -DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVT 857
D G Y A+N E A +TV+ A+P F+ + I E I VT
Sbjct: 313 DDAGTYFCIADNGNETIEAQAELTVQ------AQPE-FLKQPTNIYAHESMDIVFECEVT 365
Query: 858 RNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P P++ W +N +++ PS+ + N++ V+ V S D G Y+C+A N G +
Sbjct: 366 GKPTPTVKWVKNGDMVIPSDYF-KIVKEHNLQ-VLGLVKS--DEGFYQCIAENDVGNAQA 421
Query: 918 GARVTI 923
GA++ I
Sbjct: 422 GAQLII 427
Score = 68.1 bits (159), Expect = 3e-10
Identities = 91/384 (23%), Positives = 157/384 (40%), Gaps = 40/384 (10%)
Query: 737 VIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-----SDGDTHSITI 791
++EP+ ++ VR G SVIL+ P P I W K+ + + DG +
Sbjct: 56 LVEPVDTLSVR-GSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
Query: 792 LKPKKVK-DEGVYTLKA--ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+ K K DEG Y A E+ I +A + V A P F ++ + +V
Sbjct: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV-------AGLPRFTSQPEPSSVYAGN 167
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVA 908
L V + VP + W +N + + + + + G LVI+N +E D G Y+CV
Sbjct: 168 NAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSG---MLVISNA-TEGDGGLYRCVV 223
Query: 909 SNSAGKSSHGARVTI----DVEKVTFVKHLQKSYETEE--GKTVILECQTS--HTVSTKW 960
S G + V + D E ++ + L++ G+ V+L C S T + KW
Sbjct: 224 -ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKW 282
Query: 961 YHNKKEI-SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI--- 1016
N++ + + R ++ G D G CI + + + T+
Sbjct: 283 MKNEEALDTESSERLVLLAG--GSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQ 340
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
PEF+++ + E + E E+ + T V W ++G+++ P D+ K L
Sbjct: 341 PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPS----DYFKIVKEHNLQ 396
Query: 1076 IRNTSVHDEGEYSCILRDESCTAE 1099
+ DEG Y CI ++ A+
Sbjct: 397 VLGLVKSDEGFYQCIAENDVGNAQ 420
Score = 65.7 bits (153), Expect = 2e-09
Identities = 52/197 (26%), Positives = 87/197 (44%), Gaps = 10/197 (5%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F K+P G D++L C +P P I W+ K EE + E+ E + + L
Sbjct: 251 FLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWM-KNEEALDTESS----ERLVLLAGGSL 305
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
+I++V + GTY +A N G ++ ++ T + +P + +P ++ + ++
Sbjct: 306 EISDVTEDDAGTYFCIADN--GNETIEAQAEL-TVQAQPEFLKQPT-NIYAHESMDIVFE 361
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
+V G P PT+ W KN V H++ +L K DEG Y AEN G A+
Sbjct: 362 CEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVK-SDEGFYQCIAENDVGNAQ 420
Query: 816 TSAVITVEEPTEENAEP 832
A + + E P
Sbjct: 421 AGAQLIILEHAPATTGP 437
Score = 64.1 bits (149), Expect = 5e-09
Identities = 87/402 (21%), Positives = 151/402 (37%), Gaps = 24/402 (5%)
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVA 683
A I P F +P GS ++L C + P P I W G +V D+ +
Sbjct: 45 ASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL 104
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS 743
D ++ S + + K EG Y VA + K+ P+ +
Sbjct: 105 --PDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL--PRFTSQPEP 160
Query: 744 MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVY 803
V G + IL+ +V + P + W +N +P+ L + + ++ D G+Y
Sbjct: 161 SSVYAGNNAILNCEVNADLVPFVRWEQNRQPL-LLDDRVIKLPSGMLVISNATEGDGGLY 219
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
E+ + V P E +F+ + + + L + P P+
Sbjct: 220 RCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPT 279
Query: 864 ITWYRNNEII--SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
I W +N E + SE + G L I++V +E D+G Y C+A N A +
Sbjct: 280 IKWMKNEEALDTESSERLVLLAGG---SLEISDV-TEDDAGTYFCIADNGNETIEAQAEL 335
Query: 922 TIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEG 979
T+ + F+K Y E ++ EC+ + T + KW N + D+ +I++E
Sbjct: 336 TVQAQP-EFLKQPTNIY-AHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKE- 392
Query: 980 RXXXXXXXXXXXXDVGVIKCI----VKDQETSTMLVVKETIP 1017
D G +CI V + + L++ E P
Sbjct: 393 --HNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAP 432
Score = 46.8 bits (106), Expect = 9e-04
Identities = 23/91 (25%), Positives = 46/91 (50%), Gaps = 4/91 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++ + + + FEC+V G P P + W + ++ PS F++ + + L
Sbjct: 341 PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN----LQ 396
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ + D G + C+A+N G A + +LI+
Sbjct: 397 VLGLVKSDEGFYQCIAENDVGNAQAGAQLII 427
Score = 40.3 bits (90), Expect = 0.074
Identities = 24/92 (26%), Positives = 39/92 (42%), Gaps = 2/92 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F+++ P G V C G P P I W + + ++ +L I
Sbjct: 250 VFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGG--SLEI 307
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+V +DAGT+ C+A N + EL V+A
Sbjct: 308 SDVTEDDAGTYFCIADNGNETIEAQAELTVQA 339
>AF304305-1|AAN32614.1| 1842|Homo sapiens Down syndrome cell adhesion
molecule like-protein 1b protein.
Length = 1842
Score = 121 bits (291), Expect = 3e-26
Identities = 287/1390 (20%), Positives = 506/1390 (36%), Gaps = 133/1390 (9%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
L C P P I WL G + D + I L I++++ GTY
Sbjct: 34 LPCTAPGYPIPAIRWLKDGRPLPADSRWTKRITG--------LTISDLRTEDSGTYICEV 85
Query: 713 VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN 772
N G A +L + +P V K + G +VILS + G+P TI W +N
Sbjct: 86 TNTFGSAEATGILMVI----DPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNT 141
Query: 773 KPVKALPTKS---DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN 829
+ V LP ++ G ++ ++ + G Y A A+ A+I +E+ T
Sbjct: 142 ELV--LPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT--- 196
Query: 830 AEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-IISPSETITQNF---DG 885
P ++ F E V L+ P P++TW ++E I+ T + DG
Sbjct: 197 ---PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDG 253
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
I + D G Y+C A N G + + AR I+V ++ + ++ G+
Sbjct: 254 TTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQAR--INVRGPPSIRAM-RNITAVAGRD 310
Query: 946 VILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++ C+ S KWY + + +HR+++ E D G C V
Sbjct: 311 TLINCRVIGYPYYSIKWYKDALLLPD-NHRQVVFE-NGTLKLTDVQKGMDEGEYLCSVLI 368
Query: 1004 QETSTMLVVKETIPEFIRKLQDFEVKEKDVA-ILEVEINSETAD----VVWERDGEIIKP 1058
Q ++ + +Q FE + +L + + D + W +DG++I
Sbjct: 369 QPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVI-I 427
Query: 1059 KKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA---EVTVVELPPEIITRLQN 1115
+ E + + L I + S+ G +CI + + T +V +PP + + N
Sbjct: 428 SGSGVTIESKEFMSSLQISSVSLKHNGNDTCIASNAAATVSRERQLIVRVPPRFVVQPNN 487
Query: 1116 QKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQ-----KLKIYDCD 1169
Q G + V W + + + G+ Q L I
Sbjct: 488 QDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVL 547
Query: 1170 LDDAGEYSCEVGNSKCTAI-----LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDET 1224
+D G Y C+ N T I LTV+ P++ T I + + +
Sbjct: 548 EEDIGYYLCQASNGVGTDISKSMFLTVKIPAM-ITSHPNTTIAIKGHAKELNCTARGERP 606
Query: 1225 LDVTWYKKKSVIEDTE--KFTLIS----DVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK 1278
+ + W K +VI+ ++ + + D TL ++ D ++C +++ +
Sbjct: 607 IIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDR 666
Query: 1279 LKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS 1337
+++ V+ PP E E R + + L Q F + I I K K
Sbjct: 667 GLIQLTVQEPPD--PPELEIREVKARSMNLRWT-QRF--DGNSIITGFDIEYKNKSDSWD 721
Query: 1338 I--DSKSASLTIKKVENTD---AGIYKLRLE--NNCGHADVEMNVTI-LDKPSPPGKP-- 1387
+++ S TI + D A +Y +R+ N G ++ +TI ++ +P G P
Sbjct: 722 FKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMD 781
Query: 1388 -NILEIDSSSINICWDEP-ENTGNSTIIYYVVEYQEID--TTEWISVKNITKTQTS---- 1439
+ + S SI + W P + N I Y + Y+E + S+ + T S
Sbjct: 782 VTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYT 841
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASE-----TTEYYKVIKETKIQSPTVEKPLKNITTE 1494
+ NLK + Y A N +S T E +++ ++ + I+
Sbjct: 842 LDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWS 901
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFN 1554
L + G + Y DG+ + T R + +A+
Sbjct: 902 EPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNIT-TTRERVELRGMEKFTNYSVQVLAYT 960
Query: 1555 DHGEVETSCVVGIQQKPVITISNEDIK----QKHKVGDEWLVTAVIEGIPPPEVIWYKN- 1609
G+ S V+ IQ K + IK V WL G+ I+ +
Sbjct: 961 QAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSP 1020
Query: 1610 GNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA--GTSSVEVTLKVYDKPS 1667
G+ EY T + RI L R + A +A G SS +VT+
Sbjct: 1021 GSGQPAPSEYE--TSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTI------- 1071
Query: 1668 KPEGPVIMREIS-RESVTIEW----KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
+P G + IS +VT W + P + G K D+ + + D R
Sbjct: 1072 EPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSM-DGHRL 1130
Query: 1723 VE---TYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXI 1779
+ T ++ + + A N GF + I++ + VP
Sbjct: 1131 IHTNGTLLLRAVKAEDSGYYTCTATNTGGF------DTIIVNLLVQVPPDQPRLTVSKT- 1183
Query: 1780 DNESVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXA-RIQKLSINTTYQF 1837
S+ +TW P + NGGS I + ++ ++WK + ++ L T Y+
Sbjct: 1184 SASSITLTWIPGD-NGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKV 1242
Query: 1838 RIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLK-WTEPESNGGSP 1896
++ A+N +G+ + T G+ + F ST + L+ W +NGG P
Sbjct: 1243 KLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGW----NNGGCP 1298
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQS 1956
IT ++E++ KG +W S E + ++E R+ A N+ G T +
Sbjct: 1299 ITAIVLEYRP-KG-TWAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETAQFA 1356
Query: 1957 VRLEKHATVP 1966
+T+P
Sbjct: 1357 TLDYDGSTIP 1366
Score = 114 bits (275), Expect = 3e-24
Identities = 171/785 (21%), Positives = 311/785 (39%), Gaps = 64/785 (8%)
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT--ILKPKKVKDEGVYTLKA 807
+S+ L G P P I W K+ +P LP S T IT + + +D G Y +
Sbjct: 30 DSLQLPCTAPGYPIPAIRWLKDGRP---LPADSRW-TKRITGLTISDLRTEDSGTYICEV 85
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
N+ G AE + ++ V +P P +++ T+ L +T +P +I WY
Sbjct: 86 TNTFGSAEATGILMVIDPLHVTLTP-------KKLKTGIGSTVILSCALTGSPEFTIRWY 138
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
RN E++ P E I + G + E ++ + SG Y+C A+ A + A + ++
Sbjct: 139 RNTELVLPDEAI--SIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGT 196
Query: 928 VTFVKHL-QKSYETEEGKTVILECQTSHTVSTKWYHNKKEI----SGMDHREIIQEGRXX 982
V +K E +++ + + + W + + I S ++ + +G
Sbjct: 197 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 256
Query: 983 XXXXXXX-XXXDVGVIKCIVKDQETSTMLVVKETI--PEFIRKLQDF-EVKEKDVAILEV 1038
D GV +C ++ S + + P IR +++ V +D I
Sbjct: 257 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCR 316
Query: 1039 EINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC---ILRDES 1095
I + W +D ++ + FE G ++ ++ DEGEY C I S
Sbjct: 317 VIGYPYYSIKWYKDALLLPDNHRQVVFE-NGTLKLTDVQKGM--DEGEYLCSVLIQPQLS 373
Query: 1096 CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQ 1153
+ V V P +I + + G ++ GD +R W KDG I + +
Sbjct: 374 ISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVT 433
Query: 1154 LTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTD 1213
+ L+I L G +C N A TV P F++ P N D
Sbjct: 434 IESKEFMSSLQISSVSLKHNGNDTCIASN----AAATVSRERQLIVRVPPRFVVQPNNQD 489
Query: 1214 A-YLTVEIPDETLD------VTWYKKKSVIEDTEKFTL-----ISDVKKRTLIIRKCTED 1261
Y + + ++D V W K + + I + +L+IR E+
Sbjct: 490 GIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEE 549
Query: 1262 DQCEYTCVLLDAKST--TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFP---- 1315
D Y C + T +K V+ P I + +G L +
Sbjct: 550 DIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIII 609
Query: 1316 --QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM 1373
+ D I ++++ TK + D ++L +K + D+ + N+ G +
Sbjct: 610 RWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLI 669
Query: 1374 NVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ-EIDTTEW-ISVK 1431
+T+ + P PP + I E+ + S+N+ W + GNS I + +EY+ + D+ ++ S +
Sbjct: 670 QLTVQEPPDPP-ELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTR 727
Query: 1432 NITKT--QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
NI+ T Q +I +L S Y R Y+ N++ S+ S+ E +E P ++ L+
Sbjct: 728 NISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK--ELTISTEEAAPDGPPMDVTLQ 785
Query: 1490 NITTE 1494
+T++
Sbjct: 786 PVTSQ 790
Score = 111 bits (268), Expect = 2e-23
Identities = 189/965 (19%), Positives = 365/965 (37%), Gaps = 100/965 (10%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVE 1192
+RW KDG + + I G L I D +D+G Y CEV G+++ T IL V
Sbjct: 46 IRWLKDGRPLPADSRWTKRITG----LTISDLRTEDSGTYICEVTNTFGSAEATGILMVI 101
Query: 1193 EPSINFTLRLPEFILVPANTDAYLTVEIPDET-LDVTWYKKKSVIEDTEKFTLISDVKKR 1251
+P ++ TL P+ + + L+ + + WY+ ++ E + I +
Sbjct: 102 DP-LHVTLT-PKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAIS-IRGLSNE 158
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTTK--LKVEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
TL+I + Y C T + + + + P+IV E + G +L+
Sbjct: 159 TLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMC 218
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT-----DAGIYKLRLEN 1364
+ P P W ++ + I + + + + S TI + T D G+Y+ N
Sbjct: 219 AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARN 278
Query: 1365 NCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE-YQEI- 1422
G A+ + + + PS NI + I N YY ++ Y++
Sbjct: 279 LVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLI------NCRVIGYPYYSIKWYKDAL 332
Query: 1423 ---DTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
D + +N T T +Q Y ++ IS + +
Sbjct: 333 LLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVA----------V 382
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQP-KVTWYRDGKKLKTAKA-TYENRXXXXX 1537
+ P + +P + + + + C+ P ++TW +DG+ + + T E++
Sbjct: 383 KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS 442
Query: 1538 XXXXXXXXXXY---KCIAFNDHGEV--ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLV 1592
CIA N V E +V + + V+ +N+D G ++
Sbjct: 443 LQISSVSLKHNGNDTCIASNAAATVSRERQLIVRVPPRFVVQPNNQD----GIYGKAGVL 498
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYN---ITTKEK---TSVIRIKELKRSHSSKYTIE 1646
++G PPP+V+W K+ N ++Y+ +T + + S + I+ + Y +
Sbjct: 499 NCSVDGYPPPKVMW-KHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQ 557
Query: 1647 ASNTAGTS---SVEVTLKVYDK-PSKPEGPVIMREISRE-SVTIEWKPPLDDGGLELTKY 1701
ASN GT S+ +T+K+ S P + ++ ++E + T + P+ + ++
Sbjct: 558 ASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPI------IIRW 611
Query: 1702 AIEKHEPDNNRWIKVADVDRD-----VETYCIQKLNENCEYMFRVIAQNPVGFSEALESE 1756
D +R ++ A +D V T ++ + F A N G L
Sbjct: 612 EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQ- 670
Query: 1757 PIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXX 1816
+ ++ D P + S+ + W +G S I + +E K + W
Sbjct: 671 -LTVQEPPDPPELEIRE-----VKARSMNLRW-TQRFDGNSIITGFDIEYKNKSDSWDFK 723
Query: 1817 XXXXXXXARIQKLSI-----NTTYQFRIYARNEIGTSLPYTSDDKITIG-KTLTPPSQPR 1870
I + +I + Y R+Y+ N+IG S P ++TI + P P
Sbjct: 724 QSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEP---SKELTISTEEAAPDGPPM 780
Query: 1871 NFVVSESTSRSVTLKWTEPESN-GGSPITNYIIEFKT----VKGKSWTKIVTVGGSVHEH 1925
+ + TS+S+ + W P+ I Y I ++ G+ + G +
Sbjct: 781 DVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVY 840
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMT 1985
++N+K+ + + A N G P+ S+ + VPS P + + S++ +
Sbjct: 841 TLDNLKKFAQYGVVVQAFNRAGTG-PSSSE-INATTLEDVPSQPPENVRALSITSDVAVI 898
Query: 1986 SWGTPEWDG-GAPLLGYNIAIRDV-TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
SW P L GY + + W E+ + + +R + + Y +++ A
Sbjct: 899 SWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLA 958
Query: 2044 RNEIG 2048
+ G
Sbjct: 959 YTQAG 963
Score = 95.9 bits (228), Expect = 1e-18
Identities = 79/274 (28%), Positives = 115/274 (41%), Gaps = 26/274 (9%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
PK GS ++L C L PE I W E ++PDE IS+ S+ L IT+
Sbjct: 110 PKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSN-----ETLLITS 164
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVV 759
+K G Y A + A ++ ++ G P+++ +V GE L
Sbjct: 165 AQKSHSGAYQCFATRKAQTAQDFAIIALEDG---TPRIVSSFSEKVVNPGEQFSLMCAAK 221
Query: 760 GNPRPTITWCKNNKPV-------KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
G P PT+TW +++P+ T SDG T S + +++D GVY A N G
Sbjct: 222 GAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVG 281
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
AE A I V P I + IT + RV P SI WY+ + +
Sbjct: 282 SAEYQARINVRGPPS--------IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK-DAL 332
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
+ P F EN L +T+V +D G+Y C
Sbjct: 333 LLPDNHRQVVF--ENGTLKLTDVQKGMDEGEYLC 364
Score = 61.7 bits (143), Expect = 3e-08
Identities = 96/440 (21%), Positives = 167/440 (37%), Gaps = 36/440 (8%)
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREI- 1678
NITT + +R E ++S + + A AG L + K P P ++ +
Sbjct: 933 NITTTRERVELRGMEKFTNYSVQ--VLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVP 990
Query: 1679 -SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVA-DVDRDVETYCIQKLNENCE 1736
S SV + W PP G+ + KY I P + + + + Y I LN +
Sbjct: 991 SSASSVVVSWLPPTKPNGV-IRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQ 1049
Query: 1737 YMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGG 1796
Y+ V A G + SE + I+ A P+ +V W +
Sbjct: 1050 YLLWVAAVTSAGRGNS--SEKVTIEPAGKAPAKIISFGG-------TVTTPWMKDVRLPC 1100
Query: 1797 SPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG----TSLPYT 1852
+ + D +K R+ + N T R + G T+
Sbjct: 1101 NSVGDPAPAVKWTKDSEDSAIPVSMDGHRL--IHTNGTLLLRAVKAEDSGYYTCTATNTG 1158
Query: 1853 SDDKITIGKTL-TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS 1911
D I + + PP QPR VS++++ S+TL W P NGGS I +++++ +
Sbjct: 1159 GFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEE 1216
Query: 1912 WTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPS---P 1968
W K V + S ++++K +++A+N+VG S+ + + H PS
Sbjct: 1217 W-KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSG--RISEIIEAKTHGREPSFSKD 1273
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNI 2028
I + + + W +GG P+ + R K W G ++ + +
Sbjct: 1274 QHLFTHINSTHARLNLQGWN----NGGCPITAIVLEYR--PKGTWAWQGLRANSSGEVFL 1327
Query: 2029 RDLSENHTYMIRIYARNEIG 2048
+L E Y +R+ A N G
Sbjct: 1328 TELREATWYELRMRACNSAG 1347
Score = 59.3 bits (137), Expect = 1e-07
Identities = 101/472 (21%), Positives = 175/472 (37%), Gaps = 54/472 (11%)
Query: 516 LRPKH--TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV 573
L PK T GSTV C + G P I W+R T ++ P + + + TL+I
Sbjct: 108 LTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE--TLLITSA 165
Query: 574 FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIP 633
+G + C A A A + +E D I
Sbjct: 166 QKSHSGAYQCFATRKAQTAQDFAIIALE-------------------------DGTPRIV 200
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPD--ENISVAIESDMHMY 691
+FS+K V+ G L C P P + W E IV D + SD
Sbjct: 201 SSFSEK----VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSD-GTT 255
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
S + +T + G Y A N G A + + + PP I ++++ G
Sbjct: 256 ISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV----RGPPS-IRAMRNITAVAGRD 310
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+++ +V+G P +I W K+ + + + ++ + +K DEG Y
Sbjct: 311 TLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQP 370
Query: 812 GIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
++ + +V + V+ P P + F ++ + I V P+ ITW ++
Sbjct: 371 QLSISQSVHVAVKVP------PLIQPFEFPPASIGQLLYIPCVVSSGDMPI-RITWRKDG 423
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
++I +T L I++V + +G+ C+ASN+A S ++ + V
Sbjct: 424 QVIISGSGVTIESKEFMSSLQISSVSLK-HNGNDTCIASNAAATVSRERQLIVRVPPRFV 482
Query: 931 VKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQEGR 980
V+ + + GK +L C K W H K + + + GR
Sbjct: 483 VQ--PNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 532
Score = 54.8 bits (126), Expect = 3e-06
Identities = 34/159 (21%), Positives = 66/159 (41%), Gaps = 3/159 (1%)
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFND 1555
N+ ++L C G P P + W +DG+ L + Y C N
Sbjct: 29 NDSLQLPCTAPGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNT 88
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN 1615
G E + ++ + +T++ + K K +G +++ + G P + WY+N +
Sbjct: 89 FGSAEATGILMVIDPLHVTLTPK--KLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLP 146
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
D+ +I +++ I ++SHS Y A+ A T+
Sbjct: 147 DEAISIRGLSNETLL-ITSAQKSHSGAYQCFATRKAQTA 184
Score = 47.2 bits (107), Expect = 6e-04
Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 5/108 (4%)
Query: 499 EKPTSEEQSMAPIFVEKLRPK-HTPDGSTVQFECQVEGYPRPQITWFRQT--AIIKPSQD 555
EK T E AP + TP V+ C G P P + W + + + I S D
Sbjct: 1067 EKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMD 1126
Query: 556 FQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ TL++R V ED+G +TC A N GF + L+V+ P
Sbjct: 1127 GHRLIHTNG--TLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP 1172
Score = 45.6 bits (103), Expect = 0.002
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 4/92 (4%)
Query: 1964 TVPSPPTAP-LEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
TV PP P LEIR V + + W T +DG + + G++I ++ + + + +++
Sbjct: 672 TVQEPPDPPELEIREVKARSMNLRW-TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNIS 730
Query: 2023 TL--KFNIRDLSENHTYMIRIYARNEIGLSEP 2052
+ NI DL Y IR+Y+ N+IG SEP
Sbjct: 731 PTINQANIVDLHPASVYSIRMYSFNKIGRSEP 762
Score = 42.3 bits (95), Expect = 0.018
Identities = 53/231 (22%), Positives = 84/231 (36%), Gaps = 14/231 (6%)
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIA 666
H T ++ +PP F +P Q G +L C + P P +
Sbjct: 452 HNGNDTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVM 511
Query: 667 WLFKGEEIVPDENISVAIESDMHMYC-SVLKITNVKKFQEGTYTVVAVNREG-EASLPIV 724
W P + V + + + S L I +V + G Y A N G + S +
Sbjct: 512 WKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMF 571
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-------A 777
L +K P + + I +G + L+ G I W K + + A
Sbjct: 572 LTVKI----PAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYA 627
Query: 778 LPTKSDGDTHSITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
+ TK +GD T+ LKP D ++ A NS G +TV+EP +
Sbjct: 628 IATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD 678
Score = 40.3 bits (90), Expect = 0.074
Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 5/79 (6%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVA 585
++Q C GYP P I W + + + + L I ++ ED+GT+ C
Sbjct: 31 SLQLPCTAPGYPIPAIRWLKDGRPLPADSRWTK-----RITGLTISDLRTEDSGTYICEV 85
Query: 586 KNAAGFASSTTELIVEAPL 604
N G A +T L+V PL
Sbjct: 86 TNTFGSAEATGILMVIDPL 104
Score = 37.9 bits (84), Expect = 0.39
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 4/79 (5%)
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
V D + G P P + W K+G L D + TK T + I +L+ S Y
Sbjct: 28 VNDSLQLPCTAPGYPIPAIRWLKDGRPLPADSRW---TKRITG-LTISDLRTEDSGTYIC 83
Query: 1646 EASNTAGTSSVEVTLKVYD 1664
E +NT G++ L V D
Sbjct: 84 EVTNTFGSAEATGILMVID 102
Score = 36.7 bits (81), Expect = 0.91
Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 5/85 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV----ATLVIREVFPEDAG 579
G C V+GYP P++ W P Q + ++L+IR V ED G
Sbjct: 493 GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIG 552
Query: 580 TFTCVAKNAAGF-ASSTTELIVEAP 603
+ C A N G S + L V+ P
Sbjct: 553 YYLCQASNGVGTDISKSMFLTVKIP 577
Score = 34.7 bits (76), Expect = 3.7
Identities = 25/100 (25%), Positives = 34/100 (34%), Gaps = 4/100 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKP-SQDFQMYYDDDNVAT 567
P V K G C +G P P +TW I++ S Y D
Sbjct: 197 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTI 256
Query: 568 LVIREVFPE--DAGTFTCVAKNAAGFASSTTELIVEAPLS 605
+ P+ D G + C A+N G A + V P S
Sbjct: 257 SHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS 296
>AY273815-1|AAQ16156.1| 2623|Homo sapiens bone specific CMF608
protein.
Length = 2623
Score = 120 bits (289), Expect = 6e-26
Identities = 215/948 (22%), Positives = 368/948 (38%), Gaps = 101/948 (10%)
Query: 645 VDEGSDILLECRLVAIPEPDIAW--LFKGEEIVP-DENISVAIESDMHMYCSVLKITNVK 701
+ SD L C V P P I W + G ++ +N V + + L I V+
Sbjct: 1660 IPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN-----GTLSIQRVE 1714
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE-PLKSMIVRQGESVILSAQVVG 760
G Y A N G L + L + + PP+++E K + V G +V L + G
Sbjct: 1715 IQDRGQYLCSASNLFGTDHLHVTLSVVS---YPPRILERRTKEITVHSGSTVELKCRAEG 1771
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSIT------ILKPKKVKDEGVYTLKAENSEGIA 814
P PT+TW N+ V + S G ++ +L + D G Y A N G
Sbjct: 1772 RPSPTVTWILANQTV--VSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGG-- 1827
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWYRNN--E 871
+ S ++ + + A PP+ + + +++ V G ++KL P PS+ W ++ E
Sbjct: 1828 QDSLLVKI----QVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTE 1883
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV 931
+ T ++ F N L I N+ S D G Y+C+A++S G +T++ E+VT
Sbjct: 1884 VKPLQFTNSKLFLFSNGTLYIRNLASS-DRGTYECIATSSTGSERRVVMLTME-ERVTSP 1941
Query: 932 K---HLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHR--EIIQEGRXXXX 984
+ QK E G ++L C + + W K + HR I
Sbjct: 1942 RIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSL 2001
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFE---VKEKDVAILEV 1038
D GV C+ +++ ++++ ++ P I Q F + KD +
Sbjct: 2002 FIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCK 2061
Query: 1039 EINSETADVVWE-RDGEIIKPKKNKYDFEKRGHIRK---------LYIRNTSVHDEGEYS 1088
S ++ W DG +I N + GH + LY V +EG+Y+
Sbjct: 2062 ASGSPVPEISWSLPDGTMI---NNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYT 2118
Query: 1089 C----ILRDESCTAEVTVVELPPEI-ITRLQNQKVNKGNKATFEIELTKGD--ALVRWFK 1141
C L + +TV+ P I + N+++ G+ A + E+T GD + W
Sbjct: 2119 CYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT-GDPKPKIFWLL 2177
Query: 1142 DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN-----SKCTAILTVEEPS- 1195
+++ S I L I L D+GEY C N +K + V +P
Sbjct: 2178 PSNDM-ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPL 2236
Query: 1196 IN--FTLRLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKF-TLISDVKKR 1251
IN +T R ++ + + +V W ++ + + I+ K
Sbjct: 2237 INGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNG 2296
Query: 1252 TLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEF---PPKIVDYEREYRIKRGSDVT 1306
TL IR D ++ CV + +S +++EV+E P + + + G
Sbjct: 2297 TLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTA 2356
Query: 1307 LLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENN 1365
L P P WI+ N + + + + S I K DAG Y+ N
Sbjct: 2357 LNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNK 2416
Query: 1366 CGHADVEMNVTILDKP----SPPGKPNILEIDSSSINICWDE-PENTGNSTI-IYYVVEY 1419
G+ + + + I KP PG + +S S++ D P+ T+ YVV+
Sbjct: 2417 VGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDR 2476
Query: 1420 QEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVN-EVDISDASETTEYYKVIKETK 1478
+I+ ++I N T +K ++Y Y + + T V +
Sbjct: 2477 PQIN-GKYILHDNGTLV------IKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR 2529
Query: 1479 IQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW-YRDGKKLKTA 1525
I +P ++I T +L C+ GVP+P++TW D L TA
Sbjct: 2530 I----TNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTA 2573
Score = 105 bits (251), Expect = 2e-21
Identities = 169/798 (21%), Positives = 304/798 (38%), Gaps = 64/798 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P ++ K V GS + L+CR P P + W+ + +V + S +
Sbjct: 1745 PRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSES--SQGSRQAVVTVD 1802
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV-RQGES 751
L + N+ + G Y VA N G+ SL + +++ PP ++E + +IV GES
Sbjct: 1803 GTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAA---PPVILEQRRQVIVGTWGES 1859
Query: 752 VILSAQVVGNPRPTITWCKNN----KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ L G P+P++ W ++ KP++ +K ++ ++ D G Y A
Sbjct: 1860 LKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIA 1919
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
+S G ++T+EE P + + V + L T P P I W
Sbjct: 1920 TSSTGSERRVVMLTMEERV---TSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWR 1976
Query: 868 RNNEIISPSETITQNFDG--ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
++ + + ++ N L I +V +E DSG Y CVA N G V++ +
Sbjct: 1977 LPSKAVVDQQHRVGSWIHVYPNGSLFIGSV-TEKDSGVYLCVARNKMGDDLILMHVSLRL 2035
Query: 926 E--KVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKW-------YHNKKEISGMDHR- 973
+ K+ ++ +K + GK ++C+ S + W +N + HR
Sbjct: 2036 KPAKIDHKQYFRK--QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRT 2093
Query: 974 ---EIIQEGRXXXXXXXXXXXXDVGVI--KCIVKDQETSTMLVVKETIPEFIRKLQ-DFE 1027
+ G D + KD E L V P + + +
Sbjct: 2094 RRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKD-EMKVHLTVITAAPRIRQSNKTNKR 2152
Query: 1028 VKEKDVAILEVEINSE-TADVVW-ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEG 1085
+K D A+L+ E+ + + W ++I ++Y F G L I + D G
Sbjct: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG---SLTINKVKLLDSG 2209
Query: 1086 EYSCILR----DESCTAEVTVVELPPEIITRLQNQKVNKG-----NKATFE--IELTKGD 1134
EY C+ R D++ ++ VV PP I N+ V K +K F+ E T
Sbjct: 2210 EYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSP 2269
Query: 1135 ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEP 1194
++ D + + K L+I + L D+ ++ C N ++L V+
Sbjct: 2270 EVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLE 2329
Query: 1195 SINF----TLRLP--EFILVPANTDAYLTVEIP-DETLDVTWYKKKSV-IEDTEKFTLIS 1246
+ T R P E I+ L + + ++ W + +
Sbjct: 2330 VLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYL 2389
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLDAKS-TTKLKVEVVEFPPKIVDY-EREYRIKRGSD 1304
+ II K T +D +Y C + KL + + P I+ Y + G
Sbjct: 2390 IASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGES 2449
Query: 1305 VTLLVDYQAFPQPNDEWIVNS-KIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLE 1363
++L P+PN +W + S ++ + + I + +L IK+ D G Y + +
Sbjct: 2450 LSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQ 2509
Query: 1364 NNCGHADVEMNVTILDKP 1381
N+ GH + + V I+ P
Sbjct: 2510 NSVGHTLITVPVMIVAYP 2527
Score = 77.4 bits (182), Expect = 5e-13
Identities = 98/465 (21%), Positives = 183/465 (39%), Gaps = 25/465 (5%)
Query: 1220 IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKL 1279
+PD T+ + T ++TL ++ TL K ++ +YTC + ++
Sbjct: 2074 LPDGTMINNAMQADDSGHRTRRYTLFNN---GTLYFNKVGVAEEGDYTCYAQNTLGKDEM 2130
Query: 1280 KVE--VVEFPPKIVDYER-EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
KV V+ P+I + RIK G L + P+P W++ S + +
Sbjct: 2131 KVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRY 2190
Query: 1337 SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK--PNILEIDS 1394
+ + + SLTI KV+ D+G Y N G + ++ KP N I +
Sbjct: 2191 TFHA-NGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKA 2249
Query: 1395 SSINIC---WD-EPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSY 1449
+++ +D E T + +++ + + + + S + K T I+N++ + S
Sbjct: 2250 TAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSA 2309
Query: 1450 RFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVP 1509
F A NE S E ++++ ++P EK I + + L C G P
Sbjct: 2310 DFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK----IVAQLGKSTALNCSVDGNP 2365
Query: 1510 QPKVTWYR-DGKKLKTAKATYE----NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV 1564
P++ W +G + +Y+ + Y+C A N G +E +
Sbjct: 2366 PPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI 2425
Query: 1565 VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIW-YKNGNKLENDKEYNITT 1623
+ I QKPVI ++ K G+ + V +GIP P + W +G ++ +
Sbjct: 2426 LEIGQKPVI-LTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYI 2484
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ IKE Y +A N+ G + + V + + P +
Sbjct: 2485 LHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR 2529
Score = 76.2 bits (179), Expect = 1e-12
Identities = 99/405 (24%), Positives = 161/405 (39%), Gaps = 56/405 (13%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAI-IKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
G +++ C +G P+P + W +KP Q + TL IR + D GT+
Sbjct: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYE 1916
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
C+A ++ G L +E ++ P + K
Sbjct: 1917 CIATSSTGSERRVVMLTMEERVTS--------------------------PRIEAASQKR 1950
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS-VLKITNVK 701
V+ G +LL C P+P I W + +V ++ + S +H+Y + L I +V
Sbjct: 1951 TEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQH---RVGSWIHVYPNGSLFIGSVT 2007
Query: 702 KFQEGTYTVVAVNREGE--ASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVV 759
+ G Y VA N+ G+ + + L++K + + Q V G+ + +
Sbjct: 2008 EKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQ----VLHGKDFQVDCKAS 2063
Query: 760 GNPRPTITWCKNNKPV--KALPTKSDGD-THSITI-------LKPKKVKDEGVYTLKAEN 809
G+P P I+W + + A+ G T T+ V +EG YT A+N
Sbjct: 2064 GSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQN 2123
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW-YR 868
+ G E +TV A P + + +K T L VT +P P I W
Sbjct: 2124 TLGKDEMKVHLTV-----ITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLP 2178
Query: 869 NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+N++IS S I + N L I V +DSG+Y CVA N +G
Sbjct: 2179 SNDMISFS--IDRYTFHANGSLTINKV-KLLDSGEYVCVARNPSG 2220
Score = 75.8 bits (178), Expect = 2e-12
Identities = 196/999 (19%), Positives = 355/999 (35%), Gaps = 91/999 (9%)
Query: 733 EPPQVIE-PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI-- 789
E P+++ S + L + VGNP PTI W + + K + +
Sbjct: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPN 1705
Query: 790 -TI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
T+ ++ +++D G Y A N G ++V + P + R +EITV
Sbjct: 1706 GTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVV-----SYPPRILERRTKEITVHSG 1760
Query: 848 GTIKLVARVTRNPVPSITWYRNNEII--SPSETITQNFDGENIELVITNVDSEIDSGDYK 905
T++L R P P++TW N+ + S+ Q + LV+ N+ S D G YK
Sbjct: 1761 STVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNL-SIYDRGFYK 1819
Query: 906 CVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKW-YH 962
CVASN G+ S ++ + ++ ++ G+++ L C T S W
Sbjct: 1820 CVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLS 1879
Query: 963 NKKEISGMDH-REIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFI- 1020
+ E+ + + D G +CI S VV T+ E +
Sbjct: 1880 DGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVT 1939
Query: 1021 ------RKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIR- 1072
+ EV D +L E ++W + + ++++ +
Sbjct: 1940 SPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNG 1999
Query: 1073 KLYIRNTSVHDEGEYSCILR----DESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEI 1128
L+I + + D G Y C+ R D+ V+ + L P I Q + + F++
Sbjct: 2000 SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVS-LRLKPAKIDHKQYFRKQVLHGKDFQV 2058
Query: 1129 EL-TKGDAL--VRW-FKDGSEIQFSNHIQLTIDGKKQK---------LKIYDCDLDDAGE 1175
+ G + + W DG+ I +N +Q G + + L + + G+
Sbjct: 2059 DCKASGSPVPEISWSLPDGTMI--NNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGD 2116
Query: 1176 YSC----EVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP-DETLDVTWY 1230
Y+C +G + LTV + + A A L E+ D + W
Sbjct: 2117 YTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWL 2176
Query: 1231 --KKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEF 1286
+ +++T ++ +L I K D EY CV + T K++VV
Sbjct: 2177 LPSNDMISFSIDRYTFHAN---GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSK 2233
Query: 1287 PPKIVD-YEREYRIK----RGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID-S 1340
PP I Y IK R S + P P WI+ I + I
Sbjct: 2234 PPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVH 2293
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD---KP---SPPGKPNILEIDS 1394
K+ +L I+ V +D+ + N G + + + + +L+ +P +P + + ++
Sbjct: 2294 KNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGK 2353
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKT--NSSYRFR 1452
S+ C + II+ + S + + + S KT + ++R
Sbjct: 2354 STALNC--SVDGNPPPEIIWILPNGTRFSNGPQ-SYQYLIASNGSFIISKTTREDAGKYR 2410
Query: 1453 AYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPK 1512
A N+V + E I + + +K I+ E + L C+ G+P+P
Sbjct: 2411 CAARNKVGYIEKLVILE----IGQKPVILTYAPGTVKGIS---GESLSLHCVSDGIPKPN 2463
Query: 1513 VTW-----YRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
+ W Y + K + Y C A N G + V I
Sbjct: 2464 IKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMI 2523
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKL----ENDKEYNITT 1623
P + + G + + V G+P PE+ W + L ++ +
Sbjct: 2524 VAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQ 2583
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ I+ + S S Y A N G+ ++V
Sbjct: 2584 LHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Score = 66.5 bits (155), Expect = 1e-09
Identities = 100/441 (22%), Positives = 159/441 (36%), Gaps = 50/441 (11%)
Query: 519 KHTPDGSTVQFECQVEGYPRPQITW-FRQTAIIKPSQDFQMYYDDDNVATLVIREVFPED 577
K G T +C+V G P+P+I W +I S D ++ + +L I +V D
Sbjct: 2151 KRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHAN---GSLTINKVKLLD 2207
Query: 578 AGTFTCVAKNAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTF 636
+G + CVA+N +G + +L +V P +G +++
Sbjct: 2208 SGEYVCVARNPSGDDTKMYKLDVVSKPPLING-------------LYTNRTVIKATAVRH 2254
Query: 637 SKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLK 696
SKK +CR P P++ W+ + I + L+
Sbjct: 2255 SKKH------------FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKN---GTLE 2299
Query: 697 ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ-GESVILS 755
I NV+ + VA N GE+ L + L++ + P P IV Q G+S L+
Sbjct: 2300 IRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRR-PTFRNPFNEKIVAQLGKSTALN 2358
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSE 811
V GNP P I W N + +S S I K + +D G Y A N
Sbjct: 2359 CSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTR-EDAGKYRCAARNKV 2417
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRN--PVPSITWYRN 869
G E ++ E + P+ + + TVK L + P P+I W
Sbjct: 2418 GYIEKLVIL-------EIGQKPVILT-YAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP 2469
Query: 870 NEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVT 929
+ + I + + ++ + D G+Y C A NS G + V I
Sbjct: 2470 SGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR 2529
Query: 930 FVKHLQKSYETEEGKTVILEC 950
+S T G L C
Sbjct: 2530 ITNRPPRSIVTRTGAAFQLHC 2550
Score = 59.3 bits (137), Expect = 1e-07
Identities = 77/292 (26%), Positives = 111/292 (38%), Gaps = 28/292 (9%)
Query: 634 PTFSKKPKAQYVDE-GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PTF + V + G L C + P P+I W+ S +S ++
Sbjct: 2337 PTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPN-----GTRFSNGPQSYQYLIA 2391
Query: 693 S--VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVR-QG 749
S I+ + G Y A N+ G ++L+I G+K P ++ + G
Sbjct: 2392 SNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEI--GQK--PVILTYAPGTVKGISG 2447
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSITILKPKKVKDEGVYTLK 806
ES+ L G P+P I W + V P K + ++K D G Y K
Sbjct: 2448 ESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICK 2507
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT 865
A+NS G +ITV P A PP NR V G +L P P IT
Sbjct: 2508 AQNSVG----HTLITV--PVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT 2561
Query: 866 WYRNNEIISPSETITQNFDGENIEL----VITNVDSEIDSGDYKCVASNSAG 913
W + + + + + E + L VI N + DSG YKC A N G
Sbjct: 2562 WEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTS-DSGIYKCTAKNPLG 2612
Score = 48.8 bits (111), Expect = 2e-04
Identities = 86/406 (21%), Positives = 156/406 (38%), Gaps = 39/406 (9%)
Query: 1288 PKIVDYER-EYRIKRGSDVTLLVDYQAFPQPNDEW--IVNSKIIKKCKHTKPSIDSKSAS 1344
P+IV + + I SD L + P P W + + + K K + +
Sbjct: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT 1707
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEP 1404
L+I++VE D G Y N G + + ++++ P P ILE + I +
Sbjct: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYP-----PRILERRTKEITV----- 1757
Query: 1405 ENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISD- 1463
++G++ + E + T WI + N T S Q + ++ + I D
Sbjct: 1758 -HSGSTVELKCRAEGRPSPTVTWI-LANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDR 1815
Query: 1464 -------ASETTEYYKVIKETKIQSPTV--EKPLKNITTEPNEDIELTCIFGGVPQPKVT 1514
++ + ++K I +P V E+ + I E ++L C G PQP V
Sbjct: 1816 GFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVY 1875
Query: 1515 W-YRDGKKLKTAKATYE-----NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
W DG ++K + T + Y+CIA + G E V+
Sbjct: 1876 WVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGS-ERRVVMLTM 1934
Query: 1569 QKPVITISNEDIKQKH---KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITT-- 1623
++ V + E QK GD+ L+ G P P+++W + +K D+++ + +
Sbjct: 1935 EERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMW-RLPSKAVVDQQHRVGSWI 1993
Query: 1624 -KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ I + S Y A N G + + + + KP+K
Sbjct: 1994 HVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAK 2039
Score = 48.0 bits (109), Expect = 4e-04
Identities = 28/83 (33%), Positives = 43/83 (51%), Gaps = 4/83 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWF--RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GSTV+ +C+ EG P P +TW QT + + SQ + + TLV+ + D G +
Sbjct: 1760 GSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVD-GTLVLHNLSIYDRGFY 1818
Query: 582 TCVAKNAAGFASSTTEL-IVEAP 603
CVA N G S ++ ++ AP
Sbjct: 1819 KCVASNPGGQDSLLVKIQVIAAP 1841
Score = 47.2 bits (107), Expect = 6e-04
Identities = 45/184 (24%), Positives = 73/184 (39%), Gaps = 17/184 (9%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G + L C IP+P+I W +V I+ + +H L I + G
Sbjct: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQING--KYILHDN-GTLVIKEATAYDRGN 2503
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIE-PLKSMIVRQGESVILSAQVVGNPRPTI 766
Y A N G + + + I PP++ P +S++ R G + L +G P+P I
Sbjct: 2504 YICKAQNSVGHTLITVPVMIVA---YPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEI 2560
Query: 767 TWCKNNKPVKALPTKSDGDTH--------SITILKPKKVKDEGVYTLKAENSEGIAETSA 818
TW + + L T S TH +++ + D G+Y A+N G +
Sbjct: 2561 TWEMPDHSL--LSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAAT 2618
Query: 819 VITV 822
I V
Sbjct: 2619 YIQV 2622
Score = 44.4 bits (100), Expect = 0.005
Identities = 48/209 (22%), Positives = 77/209 (36%), Gaps = 15/209 (7%)
Query: 1497 EDIELTCIFGGVPQPKVTW-YRDGKKL-----------KTAKATYENRXXXXXXXXXXXX 1544
+D ++ C G P P+++W DG + +T + T N
Sbjct: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAE 2113
Query: 1545 XXXYKCIAFNDHGEVETSC-VVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE 1603
Y C A N G+ E + I P I SN+ K + K GD ++ + G P P+
Sbjct: 2114 EGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNK-RIKAGDTAVLDCEVTGDPKPK 2172
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+ W N + + T S + I ++K S +Y A N +G + L V
Sbjct: 2173 IFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVV 2231
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLD 1692
KP G R + + + K D
Sbjct: 2232 SKPPLINGLYTNRTVIKATAVRHSKKHFD 2260
Score = 39.9 bits (89), Expect = 0.098
Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 521 TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV---ATLVIREVFPED 577
T G+ Q C G P+P+ITW + + + + + + TLVI+ D
Sbjct: 2540 TRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSD 2599
Query: 578 AGTFTCVAKNAAGFASSTTELIV 600
+G + C AKN G + T + V
Sbjct: 2600 SGIYKCTAKNPLGSDYAATYIQV 2622
Score = 37.5 bits (83), Expect = 0.52
Identities = 26/92 (28%), Positives = 39/92 (42%), Gaps = 4/92 (4%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPD--GSTVQFECQVEGYPRPQITW-FRQTAIIKPSQDFQM 558
T EE+ +P +E K T G + C G P+PQI W A++
Sbjct: 1933 TMEERVTSPR-IEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGS 1991
Query: 559 YYDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
+ +L I V +D+G + CVA+N G
Sbjct: 1992 WIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG 2023
Score = 36.7 bits (81), Expect = 0.91
Identities = 22/69 (31%), Positives = 33/69 (47%), Gaps = 6/69 (8%)
Query: 524 GSTVQFECQVEGYPRPQITWF--RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
G T+ C G P I+W + + S+D ++ N TL I +V P+D G +
Sbjct: 588 GETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVL----NNGTLRILQVTPKDQGYY 643
Query: 582 TCVAKNAAG 590
CVA N +G
Sbjct: 644 RCVAANPSG 652
Score = 34.3 bits (75), Expect = 4.9
Identities = 48/171 (28%), Positives = 69/171 (40%), Gaps = 14/171 (8%)
Query: 749 GESVILSAQVVGNPRPTITWC-KNNKPVKALPTKSDG----DTHSITILKPKKVKDEGVY 803
G +V L+ G+P P + W + V+A DG D L+ D GVY
Sbjct: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
+ N + + ITV EP E + N TV T+ L T P S
Sbjct: 550 HCISSNYDDADILTYRITVVEPLVEAYQE----NGIHH-TVFIGETLDLPCHSTGIPDAS 604
Query: 864 ITWY-RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
I+W N ++ S + + N L I V + D G Y+CVA+N +G
Sbjct: 605 ISWVIPGNNVLYQSSRDKKVLN--NGTLRILQVTPK-DQGYYRCVAANPSG 652
Score = 34.3 bits (75), Expect = 4.9
Identities = 26/123 (21%), Positives = 43/123 (34%), Gaps = 1/123 (0%)
Query: 596 TELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDE-GSDILLE 654
T +I EA D G+ + ++ PP + +P V G+ L
Sbjct: 2490 TLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLH 2549
Query: 655 CRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVN 714
C + +P+P+I W ++ + S+ L I N + G Y A N
Sbjct: 2550 CVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKN 2609
Query: 715 REG 717
G
Sbjct: 2610 PLG 2612
>AK075220-1|BAC11480.1| 760|Homo sapiens protein ( Homo sapiens cDNA
FLJ90739 fis, clone PLACE1010968, highly similar to
FAD104. ).
Length = 760
Score = 119 bits (287), Expect = 1e-25
Identities = 123/466 (26%), Positives = 197/466 (42%), Gaps = 36/466 (7%)
Query: 1597 EGIPPPEVIWYK-NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS- 1654
EG P EVI Y + END ++ + +K LKRS K+ + ASNT G S
Sbjct: 55 EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 114
Query: 1655 --SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN-- 1710
V V D+P P P++ ++ +++W PP D+GG E+ KY +E + ++
Sbjct: 115 PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 174
Query: 1711 NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
N+W +VA E Y L Y R + G S+ ES P ++T P
Sbjct: 175 NQW-EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIAPGQC 230
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLS 1830
++ V++ W G + +Y VE+ + + L
Sbjct: 231 RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLL 290
Query: 1831 INTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPE 1890
T Y+FR+ A N+ G PY+ +IT PP Q + +S + V + W P+
Sbjct: 291 PGTVYRFRVRALNDGGYG-PYSDVSEIT--TAAGPPGQCKAPCISCTPDGCVLVGWESPD 347
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
S+ G+ I+ Y +E+ + + +++ G I ++ + R+ A N G
Sbjct: 348 SS-GADISEYRLEWG--EDEESLELIYHGTDTRFE-IRDLLPAAQYCCRLQAFNQAGAG- 402
Query: 1951 PTESQSVRLEKHATVPSPPTA-------PLEIRMVG-SNIVMTSWGTPEWDGGAPLLGYN 2002
S+ V + A+ P P + PL+ S ++ +W P D G+ +L Y
Sbjct: 403 -PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CDNGSEILAYT 460
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
I + D + T VG NT ++DL TY IRI A NEIG
Sbjct: 461 IDLGDTSIT----VG----NTTMHVMKDLLPETTYRIRIQAINEIG 498
Score = 89.0 bits (211), Expect = 2e-16
Identities = 97/413 (23%), Positives = 157/413 (38%), Gaps = 24/413 (5%)
Query: 1643 YTIEASNTAGTSSVEVTLKVY---DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELT 1699
+ + A N GTS + Y + P P P ++R VT++W P E+
Sbjct: 5 FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRA-GITWVTLQWSKPEGCSPEEVI 63
Query: 1700 KYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIV 1759
Y +E E +N+ D+ T ++ L + +Y FR+ A N G ++ SE +V
Sbjct: 64 TYTLEIQEDENDNLFHPKYTGEDL-TCTVKNLKRSTQYKFRLTASNTEG--KSCPSEVLV 120
Query: 1760 IKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI---KQEGKKWKXX 1816
T+ D P + + + W P + NGGS I+ Y +EI E +W+
Sbjct: 121 CTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVA 180
Query: 1817 XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR-NFVVS 1875
L T Y+ R I T + + + P Q R V+
Sbjct: 181 YSGSATEYTFTHLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 237
Query: 1876 ESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDE 1935
+ V L+W P S G ++ Y +E + + V G + E + N+
Sbjct: 238 RPKHKEVHLEWDVPASESGCEVSEYSVEM--TEPEDVASEVYHGPEL-ECTVGNLLPGTV 294
Query: 1936 IIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGG 1995
FR+ A N G P S + A P AP I V+ W +P+ G
Sbjct: 295 YRFRVRALNDGGYG-PYSDVS-EITTAAGPPGQCKAPC-ISCTPDGCVLVGWESPD-SSG 350
Query: 1996 APLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
A + Y + + +++ + D +F IRDL Y R+ A N+ G
Sbjct: 351 ADISEYRLEWGEDEESLELIYHGTDT---RFEIRDLLPAAQYCCRLQAFNQAG 400
Score = 72.1 bits (169), Expect = 2e-11
Identities = 52/173 (30%), Positives = 79/173 (45%), Gaps = 6/173 (3%)
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGG 1894
Y FR+ ARN+IGTS T+G PS PR + + VTL+W++PE
Sbjct: 3 YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPR---LVRAGITWVTLQWSKPEGCSP 59
Query: 1895 SPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
+ Y +E + + + G + ++N+K + FR++A NT G S P+E
Sbjct: 60 EEVITYTLEIQEDENDNLFHPKYTGEDL-TCTVKNLKRSTQYKFRLTASNTEGKSCPSEV 118
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRD 2007
P PPT PL V S+ W P+ +GG+ +L Y + I D
Sbjct: 119 LVCTTSPDR--PGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITD 169
Score = 53.6 bits (123), Expect = 7e-06
Identities = 32/138 (23%), Positives = 67/138 (48%), Gaps = 6/138 (4%)
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL-E 1391
P + + T+K ++ + ++L N G + +V + T D+P PP +P +
Sbjct: 80 PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 139
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+ S ++ WD P++ G S I+ Y++E + + +W + + T+ + +LK + Y
Sbjct: 140 VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 199
Query: 1450 RFRAYAVNEVDISDASET 1467
+ RA ++ S SE+
Sbjct: 200 KLRACCISTGGHSQCSES 217
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/113 (25%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 1358 YKLRLENNCGHADVEMNV---TILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
++L N+ G + V T+ + P P P ++ + + + W +PE +I
Sbjct: 5 FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT 64
Query: 1415 YVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASE 1466
Y +E QE + K + T +++NLK ++ Y+FR A N S SE
Sbjct: 65 YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 117
Score = 42.3 bits (95), Expect = 0.018
Identities = 57/262 (21%), Positives = 104/262 (39%), Gaps = 22/262 (8%)
Query: 1683 VTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVI 1742
+ + W+ P D+G E+ Y I+ + I V + V ++ L Y R+
Sbjct: 442 LVLNWEEPCDNGS-EILAYTIDLGDTS----ITVGNTTMHV----MKDLLPETTYRIRIQ 492
Query: 1743 AQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE-KNGGSPIID 1801
A N +G S+ I KT P +S+ + W S K + I
Sbjct: 493 AINEIGAGPF--SQFIKAKTRPLPPLPPRLECAAAG--PQSLKLKWGDSNSKTHAAEDIV 548
Query: 1802 YKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK 1861
Y ++++ K++ ++Q+L+ T Y FRI A +E G P++ + K
Sbjct: 549 YTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEG-PFSETYTFSTTK 607
Query: 1862 TLTPP-SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG 1920
++ P PR V++ S + W S G P+ NYI++ + + ++ G
Sbjct: 608 SVPPTIKAPR---VTQLEGNSCEILWETVPSMKGDPV-NYILQVLVGRESEYKQVYK--G 661
Query: 1921 SVHEHCIENIKEKDEIIFRISA 1942
I ++ + FR+ A
Sbjct: 662 EEATFQISGLQTNTDYRFRVCA 683
Score = 41.9 bits (94), Expect = 0.024
Identities = 50/221 (22%), Positives = 81/221 (36%), Gaps = 8/221 (3%)
Query: 1623 TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI-MREISRE 1681
T T++ +K+L + + I+A N G +K +P P P + +
Sbjct: 469 TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQ 528
Query: 1682 SVTIEWKPPLDDG-GLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S+ ++W E Y ++ E N R+I + TY +Q+L E Y FR
Sbjct: 529 SLKLKWGDSNSKTHAAEDIVYTLQL-EDRNKRFISI--YRGPSHTYKVQRLTEFTCYSFR 585
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
+ A + G E SE T VP ++ S I W G P+
Sbjct: 586 IQAASEAG--EGPFSETYTFSTTKSVPP-TIKAPRVTQLEGNSCEILWETVPSMKGDPVN 642
Query: 1801 DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ ++K +I L NT Y+FR+ A
Sbjct: 643 YILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 683
Score = 33.9 bits (74), Expect = 6.4
Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 1357 IYKLRL--ENNCGHADVEMNVTILDKPSPPGK---PNIL-EIDSSSINICWDEPENTGNS 1410
+YKLR + GH+ ++ + PG+ P +L +++ WD P +
Sbjct: 198 LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGC 257
Query: 1411 TIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ Y VE E + V + + + ++ NL + YRFR A+N+ S+ +E
Sbjct: 258 EVSEYSVEMTEPEDVA-SEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 315
>AK223599-1|BAD97319.1| 1204|Homo sapiens factor for adipocyte
differentiation 104 variant protein.
Length = 1204
Score = 118 bits (284), Expect = 2e-25
Identities = 122/466 (26%), Positives = 197/466 (42%), Gaps = 36/466 (7%)
Query: 1597 EGIPPPEVIWYK-NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS- 1654
EG P EVI Y + END ++ + +K LKRS K+ + ASNT G S
Sbjct: 499 EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 558
Query: 1655 --SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN-- 1710
V V D+P P P++ ++ +++W PP D+GG E+ KY +E + ++
Sbjct: 559 PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
Query: 1711 NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
N+W +VA E Y L Y R + G S+ ES P ++T P
Sbjct: 619 NQW-EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIAPGQC 674
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLS 1830
++ V++ W G + +Y VE+ + + L
Sbjct: 675 RSPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLL 734
Query: 1831 INTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPE 1890
T Y+FR+ A N+ G PY+ +IT PP Q + +S + V + W P+
Sbjct: 735 PGTVYRFRVRALNDGGYG-PYSDVSEIT--TAAGPPGQCKAPCISCTPDGCVLVGWESPD 791
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
S+ G+ I+ Y +E+ + + +++ G I ++ + R+ A N G
Sbjct: 792 SS-GADISEYRLEWG--EDEESLELIYHGTDTRFE-IRDLLPAAQYCCRLQAFNQAGAG- 846
Query: 1951 PTESQSVRLEKHATVPSPPTA-------PLEIRMVG-SNIVMTSWGTPEWDGGAPLLGYN 2002
S+ V + A+ P P + PL+ S ++ +W P + G+ +L Y
Sbjct: 847 -PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYT 904
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
I + D + T VG NT ++DL TY IRI A NEIG
Sbjct: 905 IDLGDTSIT----VG----NTTMHVMKDLLPETTYRIRIQAINEIG 942
Score = 93.1 bits (221), Expect = 1e-17
Identities = 101/438 (23%), Positives = 176/438 (40%), Gaps = 18/438 (4%)
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEA--SNTAGTSSVEVTLKVYDKPSKPEGPV 1673
D +Y I + +K+L+ + + A ++ G+ S V+ + + P
Sbjct: 326 DGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP 385
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYC-IQKLN 1732
+ S+ S+T++WK P+D+G ++T Y +E E N + + +C + KL
Sbjct: 386 KLAHRSKSSLTLQWKAPIDNGS-KITNYLLEWDEGKRNSGFRQCFFGS--QKHCKLTKLC 442
Query: 1733 ENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE 1792
Y FR+ A+N +G S S+ +V T ++P V + W E
Sbjct: 443 PAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRA-GITWVTLQWSKPE 499
Query: 1793 KNGGSPIIDYKVEIKQE--GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+I Y +EI+++ + ++ L +T Y+FR+ A N G S P
Sbjct: 500 GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK 1910
T PP++P V TS ++KW P+ NGGS I Y++E +
Sbjct: 560 SEVLVCTTSPDRPGPPTRP--LVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
Query: 1911 SWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPT 1970
+ V GS E+ ++K R +T G S +ES VR A P
Sbjct: 618 ANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA--PGQCR 675
Query: 1971 APLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRD 2030
+P + V W P + G + Y++ + + + + EV L+ + +
Sbjct: 676 SPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE-PEDVASEV--YHGPELECTVGN 732
Query: 2031 LSENHTYMIRIYARNEIG 2048
L Y R+ A N+ G
Sbjct: 733 LLPGTVYRFRVRALNDGG 750
Score = 53.6 bits (123), Expect = 7e-06
Identities = 32/138 (23%), Positives = 67/138 (48%), Gaps = 6/138 (4%)
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL-E 1391
P + + T+K ++ + ++L N G + +V + T D+P PP +P +
Sbjct: 524 PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 583
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+ S ++ WD P++ G S I+ Y++E + + +W + + T+ + +LK + Y
Sbjct: 584 VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 643
Query: 1450 RFRAYAVNEVDISDASET 1467
+ RA ++ S SE+
Sbjct: 644 KLRACCISTGGHSQCSES 661
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/113 (25%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 1358 YKLRLENNCGHADVEMNV---TILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
++L N+ G + V T+ + P P P ++ + + + W +PE +I
Sbjct: 449 FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT 508
Query: 1415 YVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASE 1466
Y +E QE + K + T +++NLK ++ Y+FR A N S SE
Sbjct: 509 YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 561
Score = 41.9 bits (94), Expect = 0.024
Identities = 50/221 (22%), Positives = 81/221 (36%), Gaps = 8/221 (3%)
Query: 1623 TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI-MREISRE 1681
T T++ +K+L + + I+A N G +K +P P P + +
Sbjct: 913 TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQ 972
Query: 1682 SVTIEWKPPLDDG-GLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S+ ++W E Y ++ E N R+I + TY +Q+L E Y FR
Sbjct: 973 SLKLKWGDSNSKTHAAEDIVYTLQL-EDRNKRFISI--YRGPSHTYKVQRLTEFTCYSFR 1029
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
+ A + G E SE T VP ++ S I W G P+
Sbjct: 1030 IQAASEAG--EGPFSETYTFSTTKSVPP-TIKAPRVTQLEGNSCEILWETVPSMKGDPVN 1086
Query: 1801 DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ ++K +I L NT Y+FR+ A
Sbjct: 1087 YILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
Score = 41.5 bits (93), Expect = 0.032
Identities = 36/163 (22%), Positives = 70/163 (42%), Gaps = 9/163 (5%)
Query: 1782 ESVYITWFPSE-KNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIY 1840
+S+ + W S K + I Y ++++ K++ ++Q+L+ T Y FRI
Sbjct: 972 QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQ 1031
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPP-SQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A +E G P++ + K++ P PR V++ S + W S G P+ N
Sbjct: 1032 AASEAGEG-PFSETYTFSTTKSVPPTIKAPR---VTQLEGNSCEILWETVPSMKGDPV-N 1086
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
YI++ + + ++ G I ++ + FR+ A
Sbjct: 1087 YILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
Score = 33.9 bits (74), Expect = 6.4
Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 1357 IYKLRL--ENNCGHADVEMNVTILDKPSPPGK---PNIL-EIDSSSINICWDEPENTGNS 1410
+YKLR + GH+ ++ + PG+ P +L +++ WD P +
Sbjct: 642 LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRSPRVLGRPKHKEVHLEWDVPASESGC 701
Query: 1411 TIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ Y VE E + V + + + ++ NL + YRFR A+N+ S+ +E
Sbjct: 702 EVSEYSVEMTEPEDVA-SEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
>BC033635-1|AAH33635.1| 753|Homo sapiens FNDC3B protein protein.
Length = 753
Score = 117 bits (282), Expect = 4e-25
Identities = 122/466 (26%), Positives = 197/466 (42%), Gaps = 36/466 (7%)
Query: 1597 EGIPPPEVIWYK-NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS- 1654
EG P EVI Y + END ++ + +K LKRS K+ + ASNT G S
Sbjct: 48 EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 107
Query: 1655 --SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN-- 1710
V V D+P P P++ ++ +++W PP D+GG E+ KY +E + ++
Sbjct: 108 PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 167
Query: 1711 NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
N+W +VA E Y L Y R + G S+ ES P ++T P
Sbjct: 168 NQW-EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIAPGQC 223
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLS 1830
++ V++ W G + +Y VE+ + + L
Sbjct: 224 RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLL 283
Query: 1831 INTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPE 1890
T Y+FR+ A N+ G PY+ +IT PP Q + +S + V + W P+
Sbjct: 284 PGTVYRFRVRALNDGGYG-PYSDVSEIT--TAAGPPGQCKAPCISCTPDGCVLVGWESPD 340
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
S+ G+ I+ Y +E+ + + +++ G I ++ + R+ A N G
Sbjct: 341 SS-GADISEYRLEWG--EDEESLELIYHGTDTRFE-IRDLLPAAQYCCRLQAFNQAGAG- 395
Query: 1951 PTESQSVRLEKHATVPSPPTA-------PLEIRMVG-SNIVMTSWGTPEWDGGAPLLGYN 2002
S+ V + A+ P P + PL+ S ++ +W P + G+ +L Y
Sbjct: 396 -PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYT 453
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
I + D + T VG NT ++DL TY IRI A NEIG
Sbjct: 454 IDLGDTSIT----VG----NTTMHVMKDLLPETTYRIRIQAINEIG 491
Score = 88.2 bits (209), Expect = 3e-16
Identities = 95/403 (23%), Positives = 154/403 (38%), Gaps = 21/403 (5%)
Query: 1650 TAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
T+G S V + + P P P ++R VT++W P E+ Y +E E +
Sbjct: 8 TSGYSQEVVCYTLGNIPQMPSAPRLVRA-GITWVTLQWSKPEGCSPEEVITYTLEIQEDE 66
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
N+ D+ T ++ L + +Y FR+ A N G ++ SE +V T+ D P
Sbjct: 67 NDNLFHPKYTGEDL-TCTVKNLKRSTQYKFRLTASNTEG--KSCPSEVLVCTTSPDRPGP 123
Query: 1770 XXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI---KQEGKKWKXXXXXXXXXARI 1826
+ + + W P + NGGS I+ Y +EI E +W+
Sbjct: 124 PTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTF 183
Query: 1827 QKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR-NFVVSESTSRSVTLK 1885
L T Y+ R I T + + + P Q R V+ + V L+
Sbjct: 184 THLKPGTLYKLRACC---ISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLE 240
Query: 1886 WTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENT 1945
W P S G ++ Y +E + + V G + E + N+ FR+ A N
Sbjct: 241 WDVPASESGCEVSEYSVEM--TEPEDVASEVYHGPEL-ECTVGNLLPGTVYRFRVRALND 297
Query: 1946 VGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAI 2005
G P S + A P AP I V+ W +P+ GA + Y +
Sbjct: 298 GGYG-PYSDVS-EITTAAGPPGQCKAPC-ISCTPDGCVLVGWESPD-SSGADISEYRLEW 353
Query: 2006 RDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
+ +++ + D +F IRDL Y R+ A N+ G
Sbjct: 354 GEDEESLELIYHGTDT---RFEIRDLLPAAQYCCRLQAFNQAG 393
Score = 53.6 bits (123), Expect = 7e-06
Identities = 32/138 (23%), Positives = 67/138 (48%), Gaps = 6/138 (4%)
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL-E 1391
P + + T+K ++ + ++L N G + +V + T D+P PP +P +
Sbjct: 73 PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 132
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+ S ++ WD P++ G S I+ Y++E + + +W + + T+ + +LK + Y
Sbjct: 133 VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 192
Query: 1450 RFRAYAVNEVDISDASET 1467
+ RA ++ S SE+
Sbjct: 193 KLRACCISTGGHSQCSES 210
Score = 44.4 bits (100), Expect = 0.005
Identities = 26/101 (25%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 1367 GHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE 1426
G++ + T+ + P P P ++ + + + W +PE +I Y +E QE +
Sbjct: 10 GYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDN 69
Query: 1427 WISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASE 1466
K + T +++NLK ++ Y+FR A N S SE
Sbjct: 70 LFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 110
Score = 41.9 bits (94), Expect = 0.024
Identities = 50/221 (22%), Positives = 81/221 (36%), Gaps = 8/221 (3%)
Query: 1623 TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI-MREISRE 1681
T T++ +K+L + + I+A N G +K +P P P + +
Sbjct: 462 TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQ 521
Query: 1682 SVTIEWKPPLDDG-GLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S+ ++W E Y ++ E N R+I + TY +Q+L E Y FR
Sbjct: 522 SLKLKWGDSNSKTHAAEDIVYTLQL-EDRNKRFISI--YRGPSHTYKVQRLTEFTCYSFR 578
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
+ A + G E SE T VP ++ S I W G P+
Sbjct: 579 IQAASEAG--EGPFSETYTFSTTKSVPP-TIKAPRVTQLEGNSCEILWETVPSMKGDPVN 635
Query: 1801 DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ ++K +I L NT Y+FR+ A
Sbjct: 636 YILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 676
Score = 41.5 bits (93), Expect = 0.032
Identities = 36/163 (22%), Positives = 70/163 (42%), Gaps = 9/163 (5%)
Query: 1782 ESVYITWFPSE-KNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIY 1840
+S+ + W S K + I Y ++++ K++ ++Q+L+ T Y FRI
Sbjct: 521 QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQ 580
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPP-SQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A +E G P++ + K++ P PR V++ S + W S G P+ N
Sbjct: 581 AASEAGEG-PFSETYTFSTTKSVPPTIKAPR---VTQLEGNSCEILWETVPSMKGDPV-N 635
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
YI++ + + ++ G I ++ + FR+ A
Sbjct: 636 YILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 676
Score = 33.9 bits (74), Expect = 6.4
Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 1357 IYKLRL--ENNCGHADVEMNVTILDKPSPPGK---PNIL-EIDSSSINICWDEPENTGNS 1410
+YKLR + GH+ ++ + PG+ P +L +++ WD P +
Sbjct: 191 LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGC 250
Query: 1411 TIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ Y VE E + V + + + ++ NL + YRFR A+N+ S+ +E
Sbjct: 251 EVSEYSVEMTEPEDVA-SEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 308
>AY358146-1|AAQ88513.1| 847|Homo sapiens YVTM2421 protein.
Length = 847
Score = 117 bits (282), Expect = 4e-25
Identities = 122/466 (26%), Positives = 197/466 (42%), Gaps = 36/466 (7%)
Query: 1597 EGIPPPEVIWYK-NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS- 1654
EG P EVI Y + END ++ + +K LKRS K+ + ASNT G S
Sbjct: 142 EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 201
Query: 1655 --SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN-- 1710
V V D+P P P++ ++ +++W PP D+GG E+ KY +E + ++
Sbjct: 202 PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 261
Query: 1711 NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
N+W +VA E Y L Y R + G S+ ES P ++T P
Sbjct: 262 NQW-EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIAPGQC 317
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLS 1830
++ V++ W G + +Y VE+ + + L
Sbjct: 318 RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLL 377
Query: 1831 INTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPE 1890
T Y+FR+ A N+ G PY+ +IT PP Q + +S + V + W P+
Sbjct: 378 PGTVYRFRVRALNDGGYG-PYSDVSEIT--TAAGPPGQCKAPCISCTPDGCVLVGWESPD 434
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
S+ G+ I+ Y +E+ + + +++ G I ++ + R+ A N G
Sbjct: 435 SS-GADISEYRLEWG--EDEESLELIYHGTDTRFE-IRDLLPAAQYCCRLQAFNQAGAG- 489
Query: 1951 PTESQSVRLEKHATVPSPPTA-------PLEIRMVG-SNIVMTSWGTPEWDGGAPLLGYN 2002
S+ V + A+ P P + PL+ S ++ +W P + G+ +L Y
Sbjct: 490 -PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYT 547
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
I + D + T VG NT ++DL TY IRI A NEIG
Sbjct: 548 IDLGDTSIT----VG----NTTMHVMKDLLPETTYRIRIQAINEIG 585
Score = 90.6 bits (215), Expect = 5e-17
Identities = 95/404 (23%), Positives = 162/404 (40%), Gaps = 16/404 (3%)
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
++ G+ S V+ + + P + S+ S+T++WK P+D+G ++T Y +E E
Sbjct: 3 NSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGS-KITNYLLEWDE 61
Query: 1708 PDNNRWIKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV 1766
N + + +C + KL Y FR+ A+N +G S S+ +V T ++
Sbjct: 62 GKRNSGFRQCFFGS--QKHCKLTKLCPAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNI 117
Query: 1767 PSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQE--GKKWKXXXXXXXXXA 1824
P V + W E +I Y +EI+++ +
Sbjct: 118 PQMPSALRLVRA-GITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTC 176
Query: 1825 RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTL 1884
++ L +T Y+FR+ A N G S P T PP++P V TS ++
Sbjct: 177 TVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRP--LVKGPVTSHGFSV 234
Query: 1885 KWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
KW P+ NGGS I Y++E ++ V GS E+ ++K R +
Sbjct: 235 KWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 294
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIA 2004
T G S +ES VR A P P + V W P + G + Y++
Sbjct: 295 TGGHSQCSESLPVRTLSIA--PGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVE 352
Query: 2005 IRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
+ + + + EV L+ + +L Y R+ A N+ G
Sbjct: 353 MTE-PEDVASEV--YHGPELECTVGNLLPGTVYRFRVRALNDGG 393
Score = 53.6 bits (123), Expect = 7e-06
Identities = 32/138 (23%), Positives = 67/138 (48%), Gaps = 6/138 (4%)
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL-E 1391
P + + T+K ++ + ++L N G + +V + T D+P PP +P +
Sbjct: 167 PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 226
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+ S ++ WD P++ G S I+ Y++E + + +W + + T+ + +LK + Y
Sbjct: 227 VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 286
Query: 1450 RFRAYAVNEVDISDASET 1467
+ RA ++ S SE+
Sbjct: 287 KLRACCISTGGHSQCSES 304
Score = 41.5 bits (93), Expect = 0.032
Identities = 29/113 (25%), Positives = 49/113 (43%), Gaps = 4/113 (3%)
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN---ICWDEPENTGNSTIIY 1414
++L N+ G + V + P P+ L + + I + W +PE +I
Sbjct: 92 FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSALRLVRAGITWVTLQWSKPEGCSPEEVIT 151
Query: 1415 YVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASE 1466
Y +E QE + K + T +++NLK ++ Y+FR A N S SE
Sbjct: 152 YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 204
Score = 40.7 bits (91), Expect = 0.056
Identities = 50/221 (22%), Positives = 81/221 (36%), Gaps = 8/221 (3%)
Query: 1623 TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI-MREISRE 1681
T T++ +K+L + + I+A N G +K +P P P + +
Sbjct: 556 TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQ 615
Query: 1682 SVTIEWKPPLDDG-GLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S+ ++W E Y ++ E N R+I + TY +Q+L E Y FR
Sbjct: 616 SLKLKWGDSNSKTHAAEDIVYTLQL-EDRNKRFISI--YRGPSHTYKVQRLTEFTCYSFR 672
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
+ A + G E SE T VP ++ S I W G P+
Sbjct: 673 IQAASEAG--EGPFSETYTFSTTKSVPP-TIKAPRVTQLEVNSCEILWETVPSMKGDPVN 729
Query: 1801 DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ ++K +I L NT Y+FR+ A
Sbjct: 730 YILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 770
Score = 40.7 bits (91), Expect = 0.056
Identities = 36/163 (22%), Positives = 70/163 (42%), Gaps = 9/163 (5%)
Query: 1782 ESVYITWFPSE-KNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIY 1840
+S+ + W S K + I Y ++++ K++ ++Q+L+ T Y FRI
Sbjct: 615 QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQ 674
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPP-SQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A +E G P++ + K++ P PR V++ S + W S G P+ N
Sbjct: 675 AASEAGEG-PFSETYTFSTTKSVPPTIKAPR---VTQLEVNSCEILWETVPSMKGDPV-N 729
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
YI++ + + ++ G I ++ + FR+ A
Sbjct: 730 YILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 770
Score = 33.9 bits (74), Expect = 6.4
Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 1357 IYKLRL--ENNCGHADVEMNVTILDKPSPPGK---PNIL-EIDSSSINICWDEPENTGNS 1410
+YKLR + GH+ ++ + PG+ P +L +++ WD P +
Sbjct: 285 LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGC 344
Query: 1411 TIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ Y VE E + V + + + ++ NL + YRFR A+N+ S+ +E
Sbjct: 345 EVSEYSVEMTEPEDVA-SEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 402
>BC039297-1|AAH39297.1| 1204|Homo sapiens fibronectin type III domain
containing 3B protein.
Length = 1204
Score = 117 bits (281), Expect = 5e-25
Identities = 122/466 (26%), Positives = 197/466 (42%), Gaps = 36/466 (7%)
Query: 1597 EGIPPPEVIWYK-NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS- 1654
EG P EVI Y + END ++ + +K LKRS K+ + ASNT G S
Sbjct: 499 EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 558
Query: 1655 --SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN-- 1710
V V D+P P P++ ++ +++W PP D+GG E+ KY +E + ++
Sbjct: 559 PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
Query: 1711 NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
N+W +VA E Y L Y R + G S+ ES P ++T P
Sbjct: 619 NQW-EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIAPGQC 674
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLS 1830
++ V++ W G + +Y VE+ + + L
Sbjct: 675 RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLL 734
Query: 1831 INTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPE 1890
T Y+FR+ A N+ G PY+ +IT PP Q + +S + V + W P+
Sbjct: 735 PGTVYRFRVRALNDGGYG-PYSDVSEIT--TAAGPPGQCKAPCISCTPDGCVLVGWESPD 791
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
S+ G+ I+ Y +E+ + + +++ G I ++ + R+ A N G
Sbjct: 792 SS-GADISEYRLEWG--EDEESLELIYHGTDTRFE-IRDLLPAAQYCCRLQAFNQAGAG- 846
Query: 1951 PTESQSVRLEKHATVPSPPTA-------PLEIRMVG-SNIVMTSWGTPEWDGGAPLLGYN 2002
S+ V + A+ P P + PL+ S ++ +W P + G+ +L Y
Sbjct: 847 -PYSELVLWQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYT 904
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
I + D + T VG NT ++DL TY IRI A NEIG
Sbjct: 905 IDLGDTSIT----VG----NTTMHVMKDLLPETTYRIRIQAINEIG 942
Score = 92.3 bits (219), Expect = 2e-17
Identities = 101/438 (23%), Positives = 175/438 (39%), Gaps = 18/438 (4%)
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEA--SNTAGTSSVEVTLKVYDKPSKPEGPV 1673
D +Y I + +K+L+ + + A ++ G+ S V+ + + P
Sbjct: 326 DGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP 385
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYC-IQKLN 1732
+ S+ S+T++WK P+D+G ++T Y +E E N + + +C + KL
Sbjct: 386 KLAHRSKSSLTLQWKAPIDNGS-KITNYLLEWDEGKRNSGFRQCFFGS--QKHCKLTKLC 442
Query: 1733 ENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE 1792
Y FR+ A+N +G S S+ +V T ++P V + W E
Sbjct: 443 PAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRA-GITWVTLQWSKPE 499
Query: 1793 KNGGSPIIDYKVEIKQE--GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+I Y +EI+++ + ++ L +T Y+FR+ A N G S P
Sbjct: 500 GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK 1910
T PP++P V TS ++KW P+ NGGS I Y++E +
Sbjct: 560 SEVLVCTTSPDRPGPPTRP--LVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
Query: 1911 SWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPT 1970
+ V GS E+ ++K R +T G S +ES VR A P
Sbjct: 618 ANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA--PGQCR 675
Query: 1971 APLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRD 2030
P + V W P + G + Y++ + + + + EV L+ + +
Sbjct: 676 PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE-PEDVASEV--YHGPELECTVGN 732
Query: 2031 LSENHTYMIRIYARNEIG 2048
L Y R+ A N+ G
Sbjct: 733 LLPGTVYRFRVRALNDGG 750
Score = 53.6 bits (123), Expect = 7e-06
Identities = 32/138 (23%), Positives = 67/138 (48%), Gaps = 6/138 (4%)
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL-E 1391
P + + T+K ++ + ++L N G + +V + T D+P PP +P +
Sbjct: 524 PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 583
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+ S ++ WD P++ G S I+ Y++E + + +W + + T+ + +LK + Y
Sbjct: 584 VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 643
Query: 1450 RFRAYAVNEVDISDASET 1467
+ RA ++ S SE+
Sbjct: 644 KLRACCISTGGHSQCSES 661
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/113 (25%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 1358 YKLRLENNCGHADVEMNV---TILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
++L N+ G + V T+ + P P P ++ + + + W +PE +I
Sbjct: 449 FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT 508
Query: 1415 YVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASE 1466
Y +E QE + K + T +++NLK ++ Y+FR A N S SE
Sbjct: 509 YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 561
Score = 41.9 bits (94), Expect = 0.024
Identities = 50/221 (22%), Positives = 81/221 (36%), Gaps = 8/221 (3%)
Query: 1623 TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI-MREISRE 1681
T T++ +K+L + + I+A N G +K +P P P + +
Sbjct: 913 TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQ 972
Query: 1682 SVTIEWKPPLDDG-GLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S+ ++W E Y ++ E N R+I + TY +Q+L E Y FR
Sbjct: 973 SLKLKWGDSNSKTHAAEDIVYTLQL-EDRNKRFISI--YRGPSHTYKVQRLTEFTCYSFR 1029
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
+ A + G E SE T VP ++ S I W G P+
Sbjct: 1030 IQAASEAG--EGPFSETYTFSTTKSVPP-TIKAPRVTQLEGNSCEILWETVPSMKGDPVN 1086
Query: 1801 DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ ++K +I L NT Y+FR+ A
Sbjct: 1087 YILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
Score = 41.5 bits (93), Expect = 0.032
Identities = 36/163 (22%), Positives = 70/163 (42%), Gaps = 9/163 (5%)
Query: 1782 ESVYITWFPSE-KNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIY 1840
+S+ + W S K + I Y ++++ K++ ++Q+L+ T Y FRI
Sbjct: 972 QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQ 1031
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPP-SQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A +E G P++ + K++ P PR V++ S + W S G P+ N
Sbjct: 1032 AASEAGEG-PFSETYTFSTTKSVPPTIKAPR---VTQLEGNSCEILWETVPSMKGDPV-N 1086
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
YI++ + + ++ G I ++ + FR+ A
Sbjct: 1087 YILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
Score = 33.9 bits (74), Expect = 6.4
Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 1357 IYKLRL--ENNCGHADVEMNVTILDKPSPPGK---PNIL-EIDSSSINICWDEPENTGNS 1410
+YKLR + GH+ ++ + PG+ P +L +++ WD P +
Sbjct: 642 LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGC 701
Query: 1411 TIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ Y VE E + V + + + ++ NL + YRFR A+N+ S+ +E
Sbjct: 702 EVSEYSVEMTEPEDVA-SEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
>BC132812-1|AAI32813.1| 1198|Homo sapiens FNDC3A protein protein.
Length = 1198
Score = 115 bits (277), Expect = 2e-24
Identities = 115/430 (26%), Positives = 181/430 (42%), Gaps = 34/430 (7%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVY---DKPSKPEGPVIMREISRESVTIEWK 1688
+K L+RS K+ + A N+ G S+ ++ DKP P P + +I S I W
Sbjct: 527 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
Query: 1689 PPLDDGGLELTKYAIEKHEPDN-NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PP D+GG + KY +E E N N+W + + +LN C Y RV +
Sbjct: 587 PPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCISDG 644
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G ++ SE ++++T P + + + W P +GGSPI Y VE+
Sbjct: 645 G--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 702
Query: 1808 Q-EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
E + + + L TY FR+ A N++G P++ +K I PP
Sbjct: 703 PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPP 759
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
Q + V+ ++ + W P SN G+ +T Y +E+ V+G +I G + +
Sbjct: 760 DQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS--MQICYCGPGL-SYE 815
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI--------RMV 1978
I+ + R+ A + VG S+ V +VP T EI
Sbjct: 816 IKGLSPATTYYCRVQALSVVGAG--PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 873
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S + SW P D G+ +L Y+I D + VGKV + I +L + TY
Sbjct: 874 PSTCLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKV----TSYIINNLQPDTTYR 925
Query: 2039 IRIYARNEIG 2048
IRI A N +G
Sbjct: 926 IRIQALNSLG 935
Score = 108 bits (260), Expect = 2e-22
Identities = 104/428 (24%), Positives = 172/428 (40%), Gaps = 30/428 (7%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISRESVTIEW 1687
+I +L + K+ + A N GTS + Y PS P PV+ + ++++W
Sbjct: 429 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA-GITWLSLQW 487
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P E Y +E E + K D+ Y ++ L + +Y F+VIA N
Sbjct: 488 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKYKFKVIAYNSE 546
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S SE + T D P I + S ITW P + NGG+ I Y VE+
Sbjct: 547 GKSN--PSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ G KW+ +L+ Y+ R+Y ++ G S + + + P
Sbjct: 605 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS---AVSESLLVQTPAVP 661
Query: 1866 PS---QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
P PR + ++ + L+W P +GGSPI+ Y +E ++ K + V G V
Sbjct: 662 PGPCLPPR--LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEV 718
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP--TAPLEIRMVGS 1980
E + ++ FR+ A N +G +E + T P PP P ++ +
Sbjct: 719 -ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI-----TTAPGPPDQCKPPQVTCRSA 772
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+W P G + Y + V + M++ L + I+ LS TY R
Sbjct: 773 TCAQVNWEVP-LSNGTDVTEYRLEWGGVEGS--MQICYCGPG-LSYEIKGLSPATTYYCR 828
Query: 2041 IYARNEIG 2048
+ A + +G
Sbjct: 829 VQALSVVG 836
Score = 99.1 bits (236), Expect = 2e-19
Identities = 111/462 (24%), Positives = 193/462 (41%), Gaps = 32/462 (6%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRS--HSSKYTIEASNTAGT-SSVEVTLKVYDKPSKPE 1670
++ K ++ E+T+ I + +LK + + +K E ++ GT S E+ + +P P
Sbjct: 317 KDGKYKSVYVGEETN-ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPN 375
Query: 1671 GPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQK 1730
P I ++ S+T++WK P D+G ++ + +E E N + + + I K
Sbjct: 376 PPRIANR-TKNSLTLQWKAPSDNGS-KIQNFVLEWDEGKGNGEFCQCYMGSQ-KQFKITK 432
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
L+ FR+ A+N G S SE ++ T+ PS ITW
Sbjct: 433 LSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAPSMPASPVLT------KAGITWLS 484
Query: 1791 SE--KNGGSPI---IDYKVEIKQE--GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
+ K G+P I Y +E+++E G +K ++ L +T Y+F++ A N
Sbjct: 485 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
G S P + T P +P V + S S + W P+ NGG+ I Y++E
Sbjct: 545 SEGKSNPSEVVEFTTCPDKPGIPVKPS--VKGKIHSHSFKITWDPPKDNGGATINKYVVE 602
Query: 1904 F-KTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
+ G W I + G+ EH + + R+ + G S S+S+ ++
Sbjct: 603 MAEGSNGNKWEMIYS--GATREHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTP 658
Query: 1963 ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
A P P P + + WG P DGG+P+ Y++ + + K EV +
Sbjct: 659 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV--YQGS 716
Query: 2023 TLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPG 2064
++ + L TY R+ A N++G P PG
Sbjct: 717 EVECTVSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAPG 757
Score = 65.3 bits (152), Expect = 2e-09
Identities = 68/286 (23%), Positives = 109/286 (38%), Gaps = 19/286 (6%)
Query: 1779 IDNESVYITWFPSEK--NGGSP------IIDYKVEIKQEGK--KWKXXXXXXXXXARIQK 1828
I +V +TW P NG + + Y+V I GK K+K +
Sbjct: 277 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 336
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
L Y ++ A P ++ T+ P+ PR ++ T S+TL+W
Sbjct: 337 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKA 393
Query: 1889 PESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGV 1948
P N GS I N+++E+ KG GS + I + FR+SA N G
Sbjct: 394 PSDN-GSKIQNFVLEWDEGKGNG-EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
Query: 1949 SLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDV 2008
S S+ V PS P +P+ + G + W P + Y + + +
Sbjct: 452 S--GFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 508
Query: 2009 TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
T + K D L + +++L + Y ++ A N G S P E
Sbjct: 509 TSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 553
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 5/138 (3%)
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL- 1390
KP D + + T+K + + +K+ N+ G + +V T DKP P KP++
Sbjct: 515 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG 574
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+I S S I WD P++ G +TI YVVE E + +W + + + L Y
Sbjct: 575 KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFY 634
Query: 1450 RFRAYAVNEVDISDASET 1467
R R Y +++ S SE+
Sbjct: 635 RLRVYCISDGGQSAVSES 652
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/91 (24%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTS 1439
PS P P + + + +++ W +P T + I Y++E +E + K + +
Sbjct: 467 PSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYT 526
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
++NL+ ++ Y+F+ A N S+ SE E+
Sbjct: 527 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
Score = 36.3 bits (80), Expect = 1.2
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 24/227 (10%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV-------- 1683
IK L + + ++A + G + PS P ++EIS + +
Sbjct: 816 IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS 875
Query: 1684 ---TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
I W+ P D G E+ Y+I+ + + KV +Y I L + Y R
Sbjct: 876 TCLAISWEKPCDHGS-EILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIR 927
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPI 1799
+ A N +G S I +KT P ++++ + W + K +
Sbjct: 928 IQALNSLGAGPF--SHMIKLKTKPLPPDPPRLECVA--FSHQNLKLKWGEGTPKTLSTDS 983
Query: 1800 IDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
I Y ++++ + ++ ++Q+L+ +T+Y+F I A NE G
Sbjct: 984 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
>BC070072-1|AAH70072.1| 853|Homo sapiens FNDC3A protein protein.
Length = 853
Score = 115 bits (277), Expect = 2e-24
Identities = 115/430 (26%), Positives = 181/430 (42%), Gaps = 34/430 (7%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVY---DKPSKPEGPVIMREISRESVTIEWK 1688
+K L+RS K+ + A N+ G S+ ++ DKP P P + +I S I W
Sbjct: 182 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 241
Query: 1689 PPLDDGGLELTKYAIEKHEPDN-NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PP D+GG + KY +E E N N+W + + +LN C Y RV +
Sbjct: 242 PPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCISDG 299
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G ++ SE ++++T P + + + W P +GGSPI Y VE+
Sbjct: 300 G--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 357
Query: 1808 Q-EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
E + + + L TY FR+ A N++G P++ +K I PP
Sbjct: 358 PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPP 414
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
Q + V+ ++ + W P SN G+ +T Y +E+ V+G +I G + +
Sbjct: 415 DQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS--MQICYCGPGL-SYE 470
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI--------RMV 1978
I+ + R+ A + VG S+ V +VP T EI
Sbjct: 471 IKGLSPATTYYCRVQALSVVGAG--RFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 528
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S + SW P D G+ +L Y+I D + VGKV + I +L + TY
Sbjct: 529 PSTCLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKV----TSYIINNLQPDTTYR 580
Query: 2039 IRIYARNEIG 2048
IRI A N +G
Sbjct: 581 IRIQALNSLG 590
Score = 108 bits (260), Expect = 2e-22
Identities = 104/428 (24%), Positives = 172/428 (40%), Gaps = 30/428 (7%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISRESVTIEW 1687
+I +L + K+ + A N GTS + Y PS P PV+ + ++++W
Sbjct: 84 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA-GITWLSLQW 142
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P E Y +E E + K D+ Y ++ L + +Y F+VIA N
Sbjct: 143 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKYKFKVIAYNSE 201
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S SE + T D P I + S ITW P + NGG+ I Y VE+
Sbjct: 202 GKSN--PSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 259
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ G KW+ +L+ Y+ R+Y ++ G S + + + P
Sbjct: 260 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS---AVSESLLVQTPAVP 316
Query: 1866 PS---QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
P PR + ++ + L+W P +GGSPI+ Y +E ++ K + V G V
Sbjct: 317 PGPCLPPR--LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEV 373
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP--TAPLEIRMVGS 1980
E + ++ FR+ A N +G +E + T P PP P ++ +
Sbjct: 374 -ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI-----TTAPGPPDQCKPPQVTCRSA 427
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+W P G + Y + V + M++ L + I+ LS TY R
Sbjct: 428 TCAQVNWEVP-LSNGTDVTEYRLEWGGVEGS--MQICYCGPG-LSYEIKGLSPATTYYCR 483
Query: 2041 IYARNEIG 2048
+ A + +G
Sbjct: 484 VQALSVVG 491
Score = 96.3 bits (229), Expect = 1e-18
Identities = 105/432 (24%), Positives = 176/432 (40%), Gaps = 29/432 (6%)
Query: 1642 KYTIEASNTAGT-SSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTK 1700
K E ++ GT S E+ + +P P P I ++ S+T++WK P D+G ++
Sbjct: 1 KVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANR-TKNSLTLQWKAPSDNGS-KIQN 58
Query: 1701 YAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVI 1760
+ +E E N + + + I KL+ FR+ A+N G S SE ++
Sbjct: 59 FVLEWDEGKGNGEFCQCYMGSQ-KQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLY 115
Query: 1761 KTALDVPSXXXXXXXXXXIDNESVYITWFPSE--KNGGSPI---IDYKVEIKQE--GKKW 1813
T+ PS ITW + K G+P I Y +E+++E G +
Sbjct: 116 YTSGCAPSMPASPVLT------KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGF 169
Query: 1814 KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV 1873
K ++ L +T Y+F++ A N G S P + T P +P V
Sbjct: 170 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS--V 227
Query: 1874 VSESTSRSVTLKWTEPESNGGSPITNYIIEF-KTVKGKSWTKIVTVGGSVHEHCIENIKE 1932
+ S S + W P+ NGG+ I Y++E + G W I + G+ EH + +
Sbjct: 228 KGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--GATREHLCDRLNP 285
Query: 1933 KDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW 1992
R+ + G S S+S+ ++ A P P P + + WG P
Sbjct: 286 GCFYRLRVYCISDGGQS--AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLV 343
Query: 1993 DGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
DGG+P+ Y++ + + K EV + ++ + L TY R+ A N++G P
Sbjct: 344 DGGSPISCYSVEMSPIEKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-P 400
Query: 2053 LESDEPFKVIPG 2064
PG
Sbjct: 401 FSEKCDITTAPG 412
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 5/138 (3%)
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL- 1390
KP D + + T+K + + +K+ N+ G + +V T DKP P KP++
Sbjct: 170 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG 229
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+I S S I WD P++ G +TI YVVE E + +W + + + L Y
Sbjct: 230 KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFY 289
Query: 1450 RFRAYAVNEVDISDASET 1467
R R Y +++ S SE+
Sbjct: 290 RLRVYCISDGGQSAVSES 307
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/91 (24%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTS 1439
PS P P + + + +++ W +P T + I Y++E +E + K + +
Sbjct: 122 PSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYT 181
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
++NL+ ++ Y+F+ A N S+ SE E+
Sbjct: 182 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 212
Score = 36.3 bits (80), Expect = 1.2
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 24/227 (10%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV-------- 1683
IK L + + ++A + G + PS P ++EIS + +
Sbjct: 471 IKGLSPATTYYCRVQALSVVGAGRFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS 530
Query: 1684 ---TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
I W+ P D G E+ Y+I+ + + KV +Y I L + Y R
Sbjct: 531 TCLAISWEKPCDHGS-EILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIR 582
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPI 1799
+ A N +G S I +KT P ++++ + W + K +
Sbjct: 583 IQALNSLGAGPF--SHMIKLKTKPLPPDPPRLECVA--FSHQNLKLKWGEGTPKTLSTDS 638
Query: 1800 IDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
I Y ++++ + ++ ++Q+L+ +T+Y+F I A NE G
Sbjct: 639 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 685
>BC060816-1|AAH60816.1| 853|Homo sapiens FNDC3A protein protein.
Length = 853
Score = 115 bits (277), Expect = 2e-24
Identities = 115/430 (26%), Positives = 181/430 (42%), Gaps = 34/430 (7%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVY---DKPSKPEGPVIMREISRESVTIEWK 1688
+K L+RS K+ + A N+ G S+ ++ DKP P P + +I S I W
Sbjct: 182 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 241
Query: 1689 PPLDDGGLELTKYAIEKHEPDN-NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PP D+GG + KY +E E N N+W + + +LN C Y RV +
Sbjct: 242 PPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCISDG 299
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G ++ SE ++++T P + + + W P +GGSPI Y VE+
Sbjct: 300 G--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 357
Query: 1808 Q-EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
E + + + L TY FR+ A N++G P++ +K I PP
Sbjct: 358 PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPP 414
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
Q + V+ ++ + W P SN G+ +T Y +E+ V+G +I G + +
Sbjct: 415 DQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS--MQICYCGPGL-SYE 470
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI--------RMV 1978
I+ + R+ A + VG S+ V +VP T EI
Sbjct: 471 IKGLSPATTYYCRVQALSVVGAG--RFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 528
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S + SW P D G+ +L Y+I D + VGKV + I +L + TY
Sbjct: 529 PSTCLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKV----TSYIINNLQPDTTYR 580
Query: 2039 IRIYARNEIG 2048
IRI A N +G
Sbjct: 581 IRIQALNSLG 590
Score = 108 bits (260), Expect = 2e-22
Identities = 104/428 (24%), Positives = 172/428 (40%), Gaps = 30/428 (7%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISRESVTIEW 1687
+I +L + K+ + A N GTS + Y PS P PV+ + ++++W
Sbjct: 84 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA-GITWLSLQW 142
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P E Y +E E + K D+ Y ++ L + +Y F+VIA N
Sbjct: 143 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKYKFKVIAYNSE 201
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S SE + T D P I + S ITW P + NGG+ I Y VE+
Sbjct: 202 GKSN--PSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 259
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ G KW+ +L+ Y+ R+Y ++ G S + + + P
Sbjct: 260 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS---AVSESLLVQTPAVP 316
Query: 1866 PS---QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
P PR + ++ + L+W P +GGSPI+ Y +E ++ K + V G V
Sbjct: 317 PGPCLPPR--LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEV 373
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP--TAPLEIRMVGS 1980
E + ++ FR+ A N +G +E + T P PP P ++ +
Sbjct: 374 -ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI-----TTAPGPPDQCKPPQVTCRSA 427
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+W P G + Y + V + M++ L + I+ LS TY R
Sbjct: 428 TCAQVNWEVP-LSNGTDVTEYRLEWGGVEGS--MQICYCGPG-LSYEIKGLSPATTYYCR 483
Query: 2041 IYARNEIG 2048
+ A + +G
Sbjct: 484 VQALSVVG 491
Score = 96.3 bits (229), Expect = 1e-18
Identities = 105/432 (24%), Positives = 176/432 (40%), Gaps = 29/432 (6%)
Query: 1642 KYTIEASNTAGT-SSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTK 1700
K E ++ GT S E+ + +P P P I ++ S+T++WK P D+G ++
Sbjct: 1 KVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANR-TKNSLTLQWKAPSDNGS-KIQN 58
Query: 1701 YAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVI 1760
+ +E E N + + + I KL+ FR+ A+N G S SE ++
Sbjct: 59 FVLEWDEGKGNGEFCQCYMGSQ-KQFKITKLSPAMGCKFRLSARNDYGTSGF--SEEVLY 115
Query: 1761 KTALDVPSXXXXXXXXXXIDNESVYITWFPSE--KNGGSPI---IDYKVEIKQE--GKKW 1813
T+ PS ITW + K G+P I Y +E+++E G +
Sbjct: 116 YTSGCAPSMPASPVLT------KAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGF 169
Query: 1814 KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV 1873
K ++ L +T Y+F++ A N G S P + T P +P V
Sbjct: 170 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPS--V 227
Query: 1874 VSESTSRSVTLKWTEPESNGGSPITNYIIEF-KTVKGKSWTKIVTVGGSVHEHCIENIKE 1932
+ S S + W P+ NGG+ I Y++E + G W I + G+ EH + +
Sbjct: 228 KGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYS--GATREHLCDRLNP 285
Query: 1933 KDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW 1992
R+ + G S S+S+ ++ A P P P + + WG P
Sbjct: 286 GCFYRLRVYCISDGGQS--AVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLV 343
Query: 1993 DGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
DGG+P+ Y++ + + K EV + ++ + L TY R+ A N++G P
Sbjct: 344 DGGSPISCYSVEMSPIEKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-P 400
Query: 2053 LESDEPFKVIPG 2064
PG
Sbjct: 401 FSEKCDITTAPG 412
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 5/138 (3%)
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL- 1390
KP D + + T+K + + +K+ N+ G + +V T DKP P KP++
Sbjct: 170 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG 229
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+I S S I WD P++ G +TI YVVE E + +W + + + L Y
Sbjct: 230 KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFY 289
Query: 1450 RFRAYAVNEVDISDASET 1467
R R Y +++ S SE+
Sbjct: 290 RLRVYCISDGGQSAVSES 307
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/91 (24%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTS 1439
PS P P + + + +++ W +P T + I Y++E +E + K + +
Sbjct: 122 PSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYT 181
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
++NL+ ++ Y+F+ A N S+ SE E+
Sbjct: 182 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 212
Score = 36.3 bits (80), Expect = 1.2
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 24/227 (10%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV-------- 1683
IK L + + ++A + G + PS P ++EIS + +
Sbjct: 471 IKGLSPATTYYCRVQALSVVGAGRFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS 530
Query: 1684 ---TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
I W+ P D G E+ Y+I+ + + KV +Y I L + Y R
Sbjct: 531 TCLAISWEKPCDHGS-EILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIR 582
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPI 1799
+ A N +G S I +KT P ++++ + W + K +
Sbjct: 583 IQALNSLGAGPF--SHMIKLKTKPLPPDPPRLECVA--FSHQNLKLKWGEGTPKTLSTDS 638
Query: 1800 IDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
I Y ++++ + ++ ++Q+L+ +T+Y+F I A NE G
Sbjct: 639 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 685
>AL137000-1|CAI39726.2| 1142|Homo sapiens fibronectin type III domain
containing 3A protein.
Length = 1142
Score = 115 bits (277), Expect = 2e-24
Identities = 115/430 (26%), Positives = 181/430 (42%), Gaps = 34/430 (7%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVY---DKPSKPEGPVIMREISRESVTIEWK 1688
+K L+RS K+ + A N+ G S+ ++ DKP P P + +I S I W
Sbjct: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 530
Query: 1689 PPLDDGGLELTKYAIEKHEPDN-NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PP D+GG + KY +E E N N+W + + +LN C Y RV +
Sbjct: 531 PPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCISDG 588
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G ++ SE ++++T P + + + W P +GGSPI Y VE+
Sbjct: 589 G--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 646
Query: 1808 Q-EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
E + + + L TY FR+ A N++G P++ +K I PP
Sbjct: 647 PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPP 703
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
Q + V+ ++ + W P SN G+ +T Y +E+ V+G +I G + +
Sbjct: 704 DQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS--MQICYCGPGL-SYE 759
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI--------RMV 1978
I+ + R+ A + VG S+ V +VP T EI
Sbjct: 760 IKGLSPATTYYCRVQALSVVGAG--PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 817
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S + SW P D G+ +L Y+I D + VGKV + I +L + TY
Sbjct: 818 PSTCLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKV----TSYIINNLQPDTTYR 869
Query: 2039 IRIYARNEIG 2048
IRI A N +G
Sbjct: 870 IRIQALNSLG 879
Score = 108 bits (260), Expect = 2e-22
Identities = 104/428 (24%), Positives = 172/428 (40%), Gaps = 30/428 (7%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISRESVTIEW 1687
+I +L + K+ + A N GTS + Y PS P PV+ + ++++W
Sbjct: 373 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA-GITWLSLQW 431
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P E Y +E E + K D+ Y ++ L + +Y F+VIA N
Sbjct: 432 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKYKFKVIAYNSE 490
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S SE + T D P I + S ITW P + NGG+ I Y VE+
Sbjct: 491 GKSN--PSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 548
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ G KW+ +L+ Y+ R+Y ++ G S + + + P
Sbjct: 549 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS---AVSESLLVQTPAVP 605
Query: 1866 PS---QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
P PR + ++ + L+W P +GGSPI+ Y +E ++ K + V G V
Sbjct: 606 PGPCLPPR--LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEV 662
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP--TAPLEIRMVGS 1980
E + ++ FR+ A N +G +E + T P PP P ++ +
Sbjct: 663 -ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI-----TTAPGPPDQCKPPQVTCRSA 716
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+W P G + Y + V + M++ L + I+ LS TY R
Sbjct: 717 TCAQVNWEVP-LSNGTDVTEYRLEWGGVEGS--MQICYCGPG-LSYEIKGLSPATTYYCR 772
Query: 2041 IYARNEIG 2048
+ A + +G
Sbjct: 773 VQALSVVG 780
Score = 99.1 bits (236), Expect = 2e-19
Identities = 111/462 (24%), Positives = 193/462 (41%), Gaps = 32/462 (6%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRS--HSSKYTIEASNTAGT-SSVEVTLKVYDKPSKPE 1670
++ K ++ E+T+ I + +LK + + +K E ++ GT S E+ + +P P
Sbjct: 261 KDGKYKSVYVGEETN-ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPN 319
Query: 1671 GPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQK 1730
P I ++ S+T++WK P D+G ++ + +E E N + + + I K
Sbjct: 320 PPRIANR-TKNSLTLQWKAPSDNGS-KIQNFVLEWDEGKGNGEFCQCYMGSQ-KQFKITK 376
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
L+ FR+ A+N G S SE ++ T+ PS ITW
Sbjct: 377 LSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAPSMPASPVLT------KAGITWLS 428
Query: 1791 SE--KNGGSPI---IDYKVEIKQE--GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
+ K G+P I Y +E+++E G +K ++ L +T Y+F++ A N
Sbjct: 429 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 488
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
G S P + T P +P V + S S + W P+ NGG+ I Y++E
Sbjct: 489 SEGKSNPSEVVEFTTCPDKPGIPVKPS--VKGKIHSHSFKITWDPPKDNGGATINKYVVE 546
Query: 1904 F-KTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
+ G W I + G+ EH + + R+ + G S S+S+ ++
Sbjct: 547 MAEGSNGNKWEMIYS--GATREHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTP 602
Query: 1963 ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
A P P P + + WG P DGG+P+ Y++ + + K EV +
Sbjct: 603 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV--YQGS 660
Query: 2023 TLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPG 2064
++ + L TY R+ A N++G P PG
Sbjct: 661 EVECTVSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAPG 701
Score = 65.3 bits (152), Expect = 2e-09
Identities = 68/286 (23%), Positives = 109/286 (38%), Gaps = 19/286 (6%)
Query: 1779 IDNESVYITWFPSEK--NGGSP------IIDYKVEIKQEGK--KWKXXXXXXXXXARIQK 1828
I +V +TW P NG + + Y+V I GK K+K +
Sbjct: 221 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 280
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
L Y ++ A P ++ T+ P+ PR ++ T S+TL+W
Sbjct: 281 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKA 337
Query: 1889 PESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGV 1948
P N GS I N+++E+ KG GS + I + FR+SA N G
Sbjct: 338 PSDN-GSKIQNFVLEWDEGKGNG-EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 395
Query: 1949 SLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDV 2008
S S+ V PS P +P+ + G + W P + Y + + +
Sbjct: 396 S--GFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 452
Query: 2009 TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
T + K D L + +++L + Y ++ A N G S P E
Sbjct: 453 TSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 497
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 5/138 (3%)
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL- 1390
KP D + + T+K + + +K+ N+ G + +V T DKP P KP++
Sbjct: 459 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG 518
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+I S S I WD P++ G +TI YVVE E + +W + + + L Y
Sbjct: 519 KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFY 578
Query: 1450 RFRAYAVNEVDISDASET 1467
R R Y +++ S SE+
Sbjct: 579 RLRVYCISDGGQSAVSES 596
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/91 (24%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTS 1439
PS P P + + + +++ W +P T + I Y++E +E + K + +
Sbjct: 411 PSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYT 470
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
++NL+ ++ Y+F+ A N S+ SE E+
Sbjct: 471 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 501
Score = 36.3 bits (80), Expect = 1.2
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 24/227 (10%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV-------- 1683
IK L + + ++A + G + PS P ++EIS + +
Sbjct: 760 IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS 819
Query: 1684 ---TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
I W+ P D G E+ Y+I+ + + KV +Y I L + Y R
Sbjct: 820 TCLAISWEKPCDHGS-EILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIR 871
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPI 1799
+ A N +G S I +KT P ++++ + W + K +
Sbjct: 872 IQALNSLGAGPF--SHMIKLKTKPLPPDPPRLECVA--FSHQNLKLKWGEGTPKTLSTDS 927
Query: 1800 IDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
I Y ++++ + ++ ++Q+L+ +T+Y+F I A NE G
Sbjct: 928 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 974
>AJ749707-1|CAG44603.1| 1134|Homo sapiens human gene expressed in
odontoblast protein protein.
Length = 1134
Score = 115 bits (277), Expect = 2e-24
Identities = 115/430 (26%), Positives = 181/430 (42%), Gaps = 34/430 (7%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVY---DKPSKPEGPVIMREISRESVTIEWK 1688
+K L+RS K+ + A N+ G S+ ++ DKP P P + +I S I W
Sbjct: 463 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 522
Query: 1689 PPLDDGGLELTKYAIEKHEPDN-NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PP D+GG + KY +E E N N+W + + +LN C Y RV +
Sbjct: 523 PPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCISDG 580
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G ++ SE ++++T P + + + W P +GGSPI Y VE+
Sbjct: 581 G--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 638
Query: 1808 Q-EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
E + + + L TY FR+ A N++G P++ +K I PP
Sbjct: 639 PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPP 695
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
Q + V+ ++ + W P SN G+ +T Y +E+ V+G +I G + +
Sbjct: 696 DQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS--MQICYCGPGL-SYE 751
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI--------RMV 1978
I+ + R+ A + VG S+ V +VP T EI
Sbjct: 752 IKGLSPATTYYCRVQALSVVGAG--PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 809
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S + SW P D G+ +L Y+I D + VGKV + I +L + TY
Sbjct: 810 PSTCLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKV----TSYIINNLQPDTTYR 861
Query: 2039 IRIYARNEIG 2048
IRI A N +G
Sbjct: 862 IRIQALNSLG 871
Score = 108 bits (260), Expect = 2e-22
Identities = 104/428 (24%), Positives = 172/428 (40%), Gaps = 30/428 (7%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISRESVTIEW 1687
+I +L + K+ + A N GTS + Y PS P PV+ + ++++W
Sbjct: 365 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA-GITWLSLQW 423
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P E Y +E E + K D+ Y ++ L + +Y F+VIA N
Sbjct: 424 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKYKFKVIAYNSE 482
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S SE + T D P I + S ITW P + NGG+ I Y VE+
Sbjct: 483 GKSN--PSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 540
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ G KW+ +L+ Y+ R+Y ++ G S + + + P
Sbjct: 541 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS---AVSESLLVQTPAVP 597
Query: 1866 PS---QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
P PR + ++ + L+W P +GGSPI+ Y +E ++ K + V G V
Sbjct: 598 PGPCLPPR--LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEV 654
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP--TAPLEIRMVGS 1980
E + ++ FR+ A N +G +E + T P PP P ++ +
Sbjct: 655 -ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI-----TTAPGPPDQCKPPQVTCRSA 708
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+W P G + Y + V + M++ L + I+ LS TY R
Sbjct: 709 TCAQVNWEVP-LSNGTDVTEYRLEWGGVEGS--MQICYCGPG-LSYEIKGLSPATTYYCR 764
Query: 2041 IYARNEIG 2048
+ A + +G
Sbjct: 765 VQALSVVG 772
Score = 99.1 bits (236), Expect = 2e-19
Identities = 111/462 (24%), Positives = 193/462 (41%), Gaps = 32/462 (6%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRS--HSSKYTIEASNTAGT-SSVEVTLKVYDKPSKPE 1670
++ K ++ E+T+ I + +LK + + +K E ++ GT S E+ + +P P
Sbjct: 253 KDGKYKSVYVGEETN-ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPN 311
Query: 1671 GPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQK 1730
P I ++ S+T++WK P D+G ++ + +E E N + + + I K
Sbjct: 312 PPRIANR-TKNSLTLQWKAPSDNGS-KIQNFVLEWDEGKGNGEFCQCYMGSQ-KQFKITK 368
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
L+ FR+ A+N G S SE ++ T+ PS ITW
Sbjct: 369 LSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAPSMPASPVLT------KAGITWLS 420
Query: 1791 SE--KNGGSPI---IDYKVEIKQE--GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
+ K G+P I Y +E+++E G +K ++ L +T Y+F++ A N
Sbjct: 421 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 480
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
G S P + T P +P V + S S + W P+ NGG+ I Y++E
Sbjct: 481 SEGKSNPSEVVEFTTCPDKPGIPVKPS--VKGKIHSHSFKITWDPPKDNGGATINKYVVE 538
Query: 1904 F-KTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
+ G W I + G+ EH + + R+ + G S S+S+ ++
Sbjct: 539 MAEGSNGNKWEMIYS--GATREHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTP 594
Query: 1963 ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
A P P P + + WG P DGG+P+ Y++ + + K EV +
Sbjct: 595 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV--YQGS 652
Query: 2023 TLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPG 2064
++ + L TY R+ A N++G P PG
Sbjct: 653 EVECTVSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAPG 693
Score = 65.3 bits (152), Expect = 2e-09
Identities = 68/286 (23%), Positives = 109/286 (38%), Gaps = 19/286 (6%)
Query: 1779 IDNESVYITWFPSEK--NGGSP------IIDYKVEIKQEGK--KWKXXXXXXXXXARIQK 1828
I +V +TW P NG + + Y+V I GK K+K +
Sbjct: 213 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 272
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
L Y ++ A P ++ T+ P+ PR ++ T S+TL+W
Sbjct: 273 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKA 329
Query: 1889 PESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGV 1948
P N GS I N+++E+ KG GS + I + FR+SA N G
Sbjct: 330 PSDN-GSKIQNFVLEWDEGKGNG-EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 387
Query: 1949 SLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDV 2008
S S+ V PS P +P+ + G + W P + Y + + +
Sbjct: 388 S--GFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 444
Query: 2009 TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
T + K D L + +++L + Y ++ A N G S P E
Sbjct: 445 TSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 489
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 5/138 (3%)
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL- 1390
KP D + + T+K + + +K+ N+ G + +V T DKP P KP++
Sbjct: 451 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG 510
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+I S S I WD P++ G +TI YVVE E + +W + + + L Y
Sbjct: 511 KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFY 570
Query: 1450 RFRAYAVNEVDISDASET 1467
R R Y +++ S SE+
Sbjct: 571 RLRVYCISDGGQSAVSES 588
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/91 (24%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTS 1439
PS P P + + + +++ W +P T + I Y++E +E + K + +
Sbjct: 403 PSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYT 462
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
++NL+ ++ Y+F+ A N S+ SE E+
Sbjct: 463 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 493
Score = 36.3 bits (80), Expect = 1.2
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 24/227 (10%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV-------- 1683
IK L + + ++A + G + PS P ++EIS + +
Sbjct: 752 IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS 811
Query: 1684 ---TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
I W+ P D G E+ Y+I+ + + KV +Y I L + Y R
Sbjct: 812 TCLAISWEKPCDHGS-EILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIR 863
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPI 1799
+ A N +G S I +KT P ++++ + W + K +
Sbjct: 864 IQALNSLGAGPF--SHMIKLKTKPLPPDPPRLECVA--FSHQNLKLKWGEGTPKTLSTDS 919
Query: 1800 IDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
I Y ++++ + ++ ++Q+L+ +T+Y+F I A NE G
Sbjct: 920 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 966
>AJ749706-1|CAG44602.1| 1198|Homo sapiens human gene expressed in
odontoblast protein protein.
Length = 1198
Score = 115 bits (277), Expect = 2e-24
Identities = 115/430 (26%), Positives = 181/430 (42%), Gaps = 34/430 (7%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVY---DKPSKPEGPVIMREISRESVTIEWK 1688
+K L+RS K+ + A N+ G S+ ++ DKP P P + +I S I W
Sbjct: 527 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 586
Query: 1689 PPLDDGGLELTKYAIEKHEPDN-NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PP D+GG + KY +E E N N+W + + +LN C Y RV +
Sbjct: 587 PPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCISDG 644
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G ++ SE ++++T P + + + W P +GGSPI Y VE+
Sbjct: 645 G--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 702
Query: 1808 Q-EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
E + + + L TY FR+ A N++G P++ +K I PP
Sbjct: 703 PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPP 759
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
Q + V+ ++ + W P SN G+ +T Y +E+ V+G +I G + +
Sbjct: 760 DQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS--MQICYCGPGL-SYE 815
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI--------RMV 1978
I+ + R+ A + VG S+ V +VP T EI
Sbjct: 816 IKGLSPATTYYCRVQALSVVGAG--PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 873
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S + SW P D G+ +L Y+I D + VGKV + I +L + TY
Sbjct: 874 PSTCLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKV----TSYIINNLQPDTTYR 925
Query: 2039 IRIYARNEIG 2048
IRI A N +G
Sbjct: 926 IRIQALNSLG 935
Score = 108 bits (260), Expect = 2e-22
Identities = 104/428 (24%), Positives = 172/428 (40%), Gaps = 30/428 (7%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISRESVTIEW 1687
+I +L + K+ + A N GTS + Y PS P PV+ + ++++W
Sbjct: 429 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA-GITWLSLQW 487
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P E Y +E E + K D+ Y ++ L + +Y F+VIA N
Sbjct: 488 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKYKFKVIAYNSE 546
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S SE + T D P I + S ITW P + NGG+ I Y VE+
Sbjct: 547 GKSN--PSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 604
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ G KW+ +L+ Y+ R+Y ++ G S + + + P
Sbjct: 605 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS---AVSESLLVQTPAVP 661
Query: 1866 PS---QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
P PR + ++ + L+W P +GGSPI+ Y +E ++ K + V G V
Sbjct: 662 PGPCLPPR--LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEV 718
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP--TAPLEIRMVGS 1980
E + ++ FR+ A N +G +E + T P PP P ++ +
Sbjct: 719 -ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI-----TTAPGPPDQCKPPQVTCRSA 772
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+W P G + Y + V + M++ L + I+ LS TY R
Sbjct: 773 TCAQVNWEVP-LSNGTDVTEYRLEWGGVEGS--MQICYCGPG-LSYEIKGLSPATTYYCR 828
Query: 2041 IYARNEIG 2048
+ A + +G
Sbjct: 829 VQALSVVG 836
Score = 99.1 bits (236), Expect = 2e-19
Identities = 111/462 (24%), Positives = 193/462 (41%), Gaps = 32/462 (6%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRS--HSSKYTIEASNTAGT-SSVEVTLKVYDKPSKPE 1670
++ K ++ E+T+ I + +LK + + +K E ++ GT S E+ + +P P
Sbjct: 317 KDGKYKSVYVGEETN-ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPN 375
Query: 1671 GPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQK 1730
P I ++ S+T++WK P D+G ++ + +E E N + + + I K
Sbjct: 376 PPRIANR-TKNSLTLQWKAPSDNGS-KIQNFVLEWDEGKGNGEFCQCYMGSQ-KQFKITK 432
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
L+ FR+ A+N G S SE ++ T+ PS ITW
Sbjct: 433 LSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAPSMPASPVLT------KAGITWLS 484
Query: 1791 SE--KNGGSPI---IDYKVEIKQE--GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
+ K G+P I Y +E+++E G +K ++ L +T Y+F++ A N
Sbjct: 485 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 544
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
G S P + T P +P V + S S + W P+ NGG+ I Y++E
Sbjct: 545 SEGKSNPSEVVEFTTCPDKPGIPVKPS--VKGKIHSHSFKITWDPPKDNGGATINKYVVE 602
Query: 1904 F-KTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
+ G W I + G+ EH + + R+ + G S S+S+ ++
Sbjct: 603 MAEGSNGNKWEMIYS--GATREHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTP 658
Query: 1963 ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
A P P P + + WG P DGG+P+ Y++ + + K EV +
Sbjct: 659 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV--YQGS 716
Query: 2023 TLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPG 2064
++ + L TY R+ A N++G P PG
Sbjct: 717 EVECTVSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAPG 757
Score = 65.3 bits (152), Expect = 2e-09
Identities = 68/286 (23%), Positives = 109/286 (38%), Gaps = 19/286 (6%)
Query: 1779 IDNESVYITWFPSEK--NGGSP------IIDYKVEIKQEGK--KWKXXXXXXXXXARIQK 1828
I +V +TW P NG + + Y+V I GK K+K +
Sbjct: 277 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 336
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
L Y ++ A P ++ T+ P+ PR ++ T S+TL+W
Sbjct: 337 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKA 393
Query: 1889 PESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGV 1948
P N GS I N+++E+ KG GS + I + FR+SA N G
Sbjct: 394 PSDN-GSKIQNFVLEWDEGKGNG-EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 451
Query: 1949 SLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDV 2008
S S+ V PS P +P+ + G + W P + Y + + +
Sbjct: 452 S--GFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 508
Query: 2009 TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
T + K D L + +++L + Y ++ A N G S P E
Sbjct: 509 TSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 553
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 5/138 (3%)
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL- 1390
KP D + + T+K + + +K+ N+ G + +V T DKP P KP++
Sbjct: 515 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG 574
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+I S S I WD P++ G +TI YVVE E + +W + + + L Y
Sbjct: 575 KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFY 634
Query: 1450 RFRAYAVNEVDISDASET 1467
R R Y +++ S SE+
Sbjct: 635 RLRVYCISDGGQSAVSES 652
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/91 (24%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTS 1439
PS P P + + + +++ W +P T + I Y++E +E + K + +
Sbjct: 467 PSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYT 526
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
++NL+ ++ Y+F+ A N S+ SE E+
Sbjct: 527 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 557
Score = 36.3 bits (80), Expect = 1.2
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 24/227 (10%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV-------- 1683
IK L + + ++A + G + PS P ++EIS + +
Sbjct: 816 IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS 875
Query: 1684 ---TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
I W+ P D G E+ Y+I+ + + KV +Y I L + Y R
Sbjct: 876 TCLAISWEKPCDHGS-EILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIR 927
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPI 1799
+ A N +G S I +KT P ++++ + W + K +
Sbjct: 928 IQALNSLGAGPF--SHMIKLKTKPLPPDPPRLECVA--FSHQNLKLKWGEGTPKTLSTDS 983
Query: 1800 IDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
I Y ++++ + ++ ++Q+L+ +T+Y+F I A NE G
Sbjct: 984 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 1030
>AB023187-1|BAA76814.2| 1151|Homo sapiens KIAA0970 protein protein.
Length = 1151
Score = 115 bits (277), Expect = 2e-24
Identities = 115/430 (26%), Positives = 181/430 (42%), Gaps = 34/430 (7%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVY---DKPSKPEGPVIMREISRESVTIEWK 1688
+K L+RS K+ + A N+ G S+ ++ DKP P P + +I S I W
Sbjct: 480 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWD 539
Query: 1689 PPLDDGGLELTKYAIEKHEPDN-NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
PP D+GG + KY +E E N N+W + + +LN C Y RV +
Sbjct: 540 PPKDNGGATINKYVVEMAEGSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCISDG 597
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G ++ SE ++++T P + + + W P +GGSPI Y VE+
Sbjct: 598 G--QSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMS 655
Query: 1808 Q-EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPP 1866
E + + + L TY FR+ A N++G P++ +K I PP
Sbjct: 656 PIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFG-PFS--EKCDITTAPGPP 712
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHC 1926
Q + V+ ++ + W P SN G+ +T Y +E+ V+G +I G + +
Sbjct: 713 DQCKPPQVTCRSATCAQVNWEVPLSN-GTDVTEYRLEWGGVEGS--MQICYCGPGL-SYE 768
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI--------RMV 1978
I+ + R+ A + VG S+ V +VP T EI
Sbjct: 769 IKGLSPATTYYCRVQALSVVGAG--PFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYS 826
Query: 1979 GSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
S + SW P D G+ +L Y+I D + VGKV + I +L + TY
Sbjct: 827 PSTCLAISWEKP-CDHGSEILAYSIDFGDKQS---LTVGKV----TSYIINNLQPDTTYR 878
Query: 2039 IRIYARNEIG 2048
IRI A N +G
Sbjct: 879 IRIQALNSLG 888
Score = 108 bits (260), Expect = 2e-22
Identities = 104/428 (24%), Positives = 172/428 (40%), Gaps = 30/428 (7%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISRESVTIEW 1687
+I +L + K+ + A N GTS + Y PS P PV+ + ++++W
Sbjct: 382 KITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKA-GITWLSLQW 440
Query: 1688 KPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPV 1747
P E Y +E E + K D+ Y ++ L + +Y F+VIA N
Sbjct: 441 SKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL-AYTVKNLRRSTKYKFKVIAYNSE 499
Query: 1748 GFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIK 1807
G S SE + T D P I + S ITW P + NGG+ I Y VE+
Sbjct: 500 GKSN--PSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMA 557
Query: 1808 Q--EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTP 1865
+ G KW+ +L+ Y+ R+Y ++ G S + + + P
Sbjct: 558 EGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQS---AVSESLLVQTPAVP 614
Query: 1866 PS---QPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV 1922
P PR + ++ + L+W P +GGSPI+ Y +E ++ K + V G V
Sbjct: 615 PGPCLPPR--LQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIE-KDEPREVYQGSEV 671
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPP--TAPLEIRMVGS 1980
E + ++ FR+ A N +G +E + T P PP P ++ +
Sbjct: 672 -ECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDI-----TTAPGPPDQCKPPQVTCRSA 725
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIR 2040
+W P G + Y + V + M++ L + I+ LS TY R
Sbjct: 726 TCAQVNWEVP-LSNGTDVTEYRLEWGGVEGS--MQICYCGPG-LSYEIKGLSPATTYYCR 781
Query: 2041 IYARNEIG 2048
+ A + +G
Sbjct: 782 VQALSVVG 789
Score = 99.1 bits (236), Expect = 2e-19
Identities = 111/462 (24%), Positives = 193/462 (41%), Gaps = 32/462 (6%)
Query: 1614 ENDKEYNITTKEKTSVIRIKELKRS--HSSKYTIEASNTAGT-SSVEVTLKVYDKPSKPE 1670
++ K ++ E+T+ I + +LK + + +K E ++ GT S E+ + +P P
Sbjct: 270 KDGKYKSVYVGEETN-ITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPN 328
Query: 1671 GPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQK 1730
P I ++ S+T++WK P D+G ++ + +E E N + + + I K
Sbjct: 329 PPRIANR-TKNSLTLQWKAPSDNGS-KIQNFVLEWDEGKGNGEFCQCYMGSQ-KQFKITK 385
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
L+ FR+ A+N G S SE ++ T+ PS ITW
Sbjct: 386 LSPAMGCKFRLSARNDYGTSGF--SEEVLYYTSGCAPSMPASPVLT------KAGITWLS 437
Query: 1791 SE--KNGGSPI---IDYKVEIKQE--GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
+ K G+P I Y +E+++E G +K ++ L +T Y+F++ A N
Sbjct: 438 LQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYN 497
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
G S P + T P +P V + S S + W P+ NGG+ I Y++E
Sbjct: 498 SEGKSNPSEVVEFTTCPDKPGIPVKPS--VKGKIHSHSFKITWDPPKDNGGATINKYVVE 555
Query: 1904 F-KTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
+ G W I + G+ EH + + R+ + G S S+S+ ++
Sbjct: 556 MAEGSNGNKWEMIYS--GATREHLCDRLNPGCFYRLRVYCISDGGQS--AVSESLLVQTP 611
Query: 1963 ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN 2022
A P P P + + WG P DGG+P+ Y++ + + K EV +
Sbjct: 612 AVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREV--YQGS 669
Query: 2023 TLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPG 2064
++ + L TY R+ A N++G P PG
Sbjct: 670 EVECTVSSLLPGKTYSFRLRAANKMGFG-PFSEKCDITTAPG 710
Score = 65.3 bits (152), Expect = 2e-09
Identities = 68/286 (23%), Positives = 109/286 (38%), Gaps = 19/286 (6%)
Query: 1779 IDNESVYITWFPSEK--NGGSP------IIDYKVEIKQEGK--KWKXXXXXXXXXARIQK 1828
I +V +TW P NG + + Y+V I GK K+K +
Sbjct: 230 IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITLND 289
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
L Y ++ A P ++ T+ P+ PR ++ T S+TL+W
Sbjct: 290 LKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPR---IANRTKNSLTLQWKA 346
Query: 1889 PESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGV 1948
P N GS I N+++E+ KG GS + I + FR+SA N G
Sbjct: 347 PSDN-GSKIQNFVLEWDEGKGNG-EFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYGT 404
Query: 1949 SLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDV 2008
S S+ V PS P +P+ + G + W P + Y + + +
Sbjct: 405 S--GFSEEVLYYTSGCAPSMPASPV-LTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE 461
Query: 2009 TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLE 2054
T + K D L + +++L + Y ++ A N G S P E
Sbjct: 462 TSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSE 506
Score = 59.7 bits (138), Expect = 1e-07
Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 5/138 (3%)
Query: 1335 KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL- 1390
KP D + + T+K + + +K+ N+ G + +V T DKP P KP++
Sbjct: 468 KPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKG 527
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+I S S I WD P++ G +TI YVVE E + +W + + + L Y
Sbjct: 528 KIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFY 587
Query: 1450 RFRAYAVNEVDISDASET 1467
R R Y +++ S SE+
Sbjct: 588 RLRVYCISDGGQSAVSES 605
Score = 41.1 bits (92), Expect = 0.042
Identities = 22/91 (24%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVK-NITKTQTS 1439
PS P P + + + +++ W +P T + I Y++E +E + K + +
Sbjct: 420 PSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYT 479
Query: 1440 IQNLKTNSSYRFRAYAVNEVDISDASETTEY 1470
++NL+ ++ Y+F+ A N S+ SE E+
Sbjct: 480 VKNLRRSTKYKFKVIAYNSEGKSNPSEVVEF 510
Score = 36.3 bits (80), Expect = 1.2
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 24/227 (10%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESV-------- 1683
IK L + + ++A + G + PS P ++EIS + +
Sbjct: 769 IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENPHYSPS 828
Query: 1684 ---TIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
I W+ P D G E+ Y+I+ + + KV +Y I L + Y R
Sbjct: 829 TCLAISWEKPCDHGS-EILAYSIDFGDKQSLTVGKVT-------SYIINNLQPDTTYRIR 880
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPI 1799
+ A N +G S I +KT P ++++ + W + K +
Sbjct: 881 IQALNSLGAGPF--SHMIKLKTKPLPPDPPRLECVA--FSHQNLKLKWGEGTPKTLSTDS 936
Query: 1800 IDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
I Y ++++ + ++ ++Q+L+ +T+Y+F I A NE G
Sbjct: 937 IQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG 983
>AB098597-1|BAC53727.1| 1204|Homo sapiens FAD104 protein.
Length = 1204
Score = 115 bits (276), Expect = 2e-24
Identities = 121/466 (25%), Positives = 196/466 (42%), Gaps = 36/466 (7%)
Query: 1597 EGIPPPEVIWYK-NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS- 1654
EG P EVI Y + END ++ + +K LKRS + + ASNT G S
Sbjct: 499 EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYTFRLTASNTEGKSC 558
Query: 1655 --SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN-- 1710
V V D+P P P++ ++ +++W PP D+GG E+ KY +E + ++
Sbjct: 559 PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
Query: 1711 NRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXX 1770
N+W +VA E Y L Y R + G S+ ES P ++T P
Sbjct: 619 NQW-EVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIAPGQC 674
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLS 1830
++ V++ W G + +Y VE+ + + L
Sbjct: 675 RPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLL 734
Query: 1831 INTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPE 1890
T Y+FR+ A N+ G PY+ +IT PP Q + +S + V + W P+
Sbjct: 735 PGTVYRFRVRALNDGGYG-PYSDVSEIT--TAAGPPGQCKAPCISCTPDGCVLVGWESPD 791
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
S+ G+ I+ Y +E+ + + +++ G I ++ + R+ A N G
Sbjct: 792 SS-GADISEYRLEWG--EDEESLELIYHGTDTRFE-IRDLLPAAQYCCRLQAFNQAGAG- 846
Query: 1951 PTESQSVRLEKHATVPSPPTA-------PLEIRMVG-SNIVMTSWGTPEWDGGAPLLGYN 2002
S+ V + A+ P P + PL+ S ++ +W P + G+ +L Y
Sbjct: 847 -PYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEP-CNNGSEILAYT 904
Query: 2003 IAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
I + D + T VG NT ++DL TY IRI A NEIG
Sbjct: 905 IDLGDTSIT----VG----NTTMHVMKDLLPETTYRIRIQAINEIG 942
Score = 91.5 bits (217), Expect = 3e-17
Identities = 101/438 (23%), Positives = 174/438 (39%), Gaps = 18/438 (4%)
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEA--SNTAGTSSVEVTLKVYDKPSKPEGPV 1673
D +Y I + +K+L+ + + A ++ G+ S V+ + + P
Sbjct: 326 DGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP 385
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYC-IQKLN 1732
+ S+ S+T++WK P+D+G ++T Y +E E N + + +C + KL
Sbjct: 386 KLAHRSKSSLTLQWKAPIDNGS-KITNYLLEWDEGKRNSGFRQCFFGS--QKHCKLTKLC 442
Query: 1733 ENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE 1792
Y FR+ A+N +G S S+ +V T ++P V + W E
Sbjct: 443 PAMGYTFRLAARNDIGTSG--YSQEVVCYTLGNIPQMPSAPRLVRA-GITWVTLQWSKPE 499
Query: 1793 KNGGSPIIDYKVEIKQE--GKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+I Y +EI+++ + ++ L +T Y FR+ A N G S P
Sbjct: 500 GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYTFRLTASNTEGKSCP 559
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK 1910
T PP++P V TS ++KW P+ NGGS I Y++E +
Sbjct: 560 SEVLVCTTSPDRPGPPTRP--LVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
Query: 1911 SWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPT 1970
+ V GS E+ ++K R +T G S +ES VR A P
Sbjct: 618 ANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIA--PGQCR 675
Query: 1971 APLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRD 2030
P + V W P + G + Y++ + + + + EV L+ + +
Sbjct: 676 PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTE-PEDVASEV--YHGPELECTVGN 732
Query: 2031 LSENHTYMIRIYARNEIG 2048
L Y R+ A N+ G
Sbjct: 733 LLPGTVYRFRVRALNDGG 750
Score = 54.4 bits (125), Expect = 4e-06
Identities = 32/138 (23%), Positives = 67/138 (48%), Gaps = 6/138 (4%)
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL-E 1391
P + + T+K ++ + ++L N G + +V + T D+P PP +P +
Sbjct: 524 PKYTGEDLTCTVKNLKRSTQYTFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 583
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVEYQE--IDTTEWISVKNITKTQTSIQNLKTNSSY 1449
+ S ++ WD P++ G S I+ Y++E + + +W + + T+ + +LK + Y
Sbjct: 584 VTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 643
Query: 1450 RFRAYAVNEVDISDASET 1467
+ RA ++ S SE+
Sbjct: 644 KLRACCISTGGHSQCSES 661
Score = 44.4 bits (100), Expect = 0.005
Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 4/113 (3%)
Query: 1358 YKLRLENNCGHADVEMNV---TILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
++L N+ G + V T+ + P P P ++ + + + W +PE +I
Sbjct: 449 FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT 508
Query: 1415 YVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASE 1466
Y +E QE + K + T +++NLK ++ Y FR A N S SE
Sbjct: 509 YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYTFRLTASNTEGKSCPSE 561
Score = 41.9 bits (94), Expect = 0.024
Identities = 50/221 (22%), Positives = 81/221 (36%), Gaps = 8/221 (3%)
Query: 1623 TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI-MREISRE 1681
T T++ +K+L + + I+A N G +K +P P P + +
Sbjct: 913 TVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQ 972
Query: 1682 SVTIEWKPPLDDG-GLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S+ ++W E Y ++ E N R+I + TY +Q+L E Y FR
Sbjct: 973 SLKLKWGDSNSKTHAAEDIVYTLQL-EDRNKRFISI--YRGPSHTYKVQRLTEFTCYSFR 1029
Query: 1741 VIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPII 1800
+ A + G E SE T VP ++ S I W G P+
Sbjct: 1030 IQAASEAG--EGPFSETYTFSTTKSVPP-TIKAPRVTQLEGNSCEILWETVPSMKGDPVN 1086
Query: 1801 DYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYA 1841
+ ++K +I L NT Y+FR+ A
Sbjct: 1087 YILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
Score = 41.5 bits (93), Expect = 0.032
Identities = 36/163 (22%), Positives = 70/163 (42%), Gaps = 9/163 (5%)
Query: 1782 ESVYITWFPSE-KNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIY 1840
+S+ + W S K + I Y ++++ K++ ++Q+L+ T Y FRI
Sbjct: 972 QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQ 1031
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPP-SQPRNFVVSESTSRSVTLKWTEPESNGGSPITN 1899
A +E G P++ + K++ P PR V++ S + W S G P+ N
Sbjct: 1032 AASEAGEG-PFSETYTFSTTKSVPPTIKAPR---VTQLEGNSCEILWETVPSMKGDPV-N 1086
Query: 1900 YIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISA 1942
YI++ + + ++ G I ++ + FR+ A
Sbjct: 1087 YILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
Score = 33.9 bits (74), Expect = 6.4
Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 1357 IYKLRL--ENNCGHADVEMNVTILDKPSPPGK---PNIL-EIDSSSINICWDEPENTGNS 1410
+YKLR + GH+ ++ + PG+ P +L +++ WD P +
Sbjct: 642 LYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGC 701
Query: 1411 TIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ Y VE E + V + + + ++ NL + YRFR A+N+ S+ +E
Sbjct: 702 EVSEYSVEMTEPEDVA-SEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
>AB209851-1|BAD93088.1| 2331|Homo sapiens Basement membrane-specific
heparan sulfate proteoglycan core protein precursor
protein.
Length = 2331
Score = 114 bits (274), Expect = 4e-24
Identities = 178/814 (21%), Positives = 311/814 (38%), Gaps = 104/814 (12%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
PI++E H +G T+ C V G Q+TW+++ + P++ + + L
Sbjct: 866 PIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL-PARH------QTHGSQLR 917
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
+ V P D+G + C A + G V P S+ GS +
Sbjct: 918 LHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSE-GSSYRLRS-------------- 961
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDM 688
P S P + V +G D +C + P + W + +E+ ++N+ ++
Sbjct: 962 ----PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNG-- 1013
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVR 747
S++ I + GTY VA N G A + L + PP V + P + V+
Sbjct: 1014 ----SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHG----PPTVSVLPEGPVWVK 1065
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG--DTHSITILKPKKVKDEGVYTL 805
G++V L G PR + W + + L ++ G D+H++ + K D G Y
Sbjct: 1066 VGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVC 1125
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A+N+ G A+ + V+ P + E+TV+ T L T +P P+I
Sbjct: 1126 LAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE-AELTVEAGHTATLRCSATGSPAPTIH 1184
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W +++ SP + + E L+I V + DSG Y C A++ AG + A + + V
Sbjct: 1185 W---SKLRSP---LPWQYRLEGDTLIIPRVAQQ-DSGQYICNATSPAGHAE--ATIILHV 1235
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXX 983
E + + + + G+TV L+C T ++ +W + G R
Sbjct: 1236 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR------ATARNEL 1289
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G +C V ++ S + + L + ++V E
Sbjct: 1290 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE 1349
Query: 1044 TADVVWERDGEIIKPKKNKYD---FEKRGHIRK--------LYIRNTSVHDEGEYSCILR 1092
T + + P F++ G + L I+N +G Y C
Sbjct: 1350 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 1409
Query: 1093 DE----SCTAEVTVVELPPEIIT-RLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSE 1145
+A++ + LP +I R Q V G+ FE L GD V W K G
Sbjct: 1410 GPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC-LALGDPKPQVTWSKVGG- 1467
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT----AILTVEE-PSINFTL 1200
H++ I ++I +L DAG+Y C N+ T +L V+ P I+
Sbjct: 1468 -----HLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS--- 1519
Query: 1201 RLPEFILVPANTDA-YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
+P+ + VPA + A + + T D++W K + S ++ L++
Sbjct: 1520 -MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPD------SRLENNMLMLPSVR 1572
Query: 1260 EDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDY 1293
D Y C + + K ++ P ++V Y
Sbjct: 1573 PQDAGTYVCTATNRQGKVKAFAH-LQVPERVVPY 1605
Score = 87.8 bits (208), Expect = 4e-16
Identities = 205/1006 (20%), Positives = 354/1006 (35%), Gaps = 118/1006 (11%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ PT + + V EG + L C + + W +G ++ + +
Sbjct: 374 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGG----------SLPARHQV 423
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLK----SM 744
+ S L++ V G Y V G EAS+ + ++ + V P++ S
Sbjct: 424 HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSA 483
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD--GDTHSITILKPKKVKDEGV 802
+ G ++ L+ V TITW K +LP++ G I + P D G
Sbjct: 484 SLANGHTLDLNCLVASQAPHTITWYKRG---GSLPSRHQIVGSRLRIPQVTP---ADSGE 537
Query: 803 YTLKAENSEGIAETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRN 859
Y N G ETS ++T++ + PP+ I TV E T+ L V R
Sbjct: 538 YVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES-SSPTVVEGQTLDLNCVVARQ 596
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P ITWY+ + PS T G ++ L + S DSG+Y C A+N+
Sbjct: 597 PQAIITWYKRGGSL-PSRHQTH---GSHLRL---HQMSVADSGEYVCRANNNIDALEASI 649
Query: 920 RVTIDVE--------KVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWY------- 961
+++ ++ S EG+T+ L C +H T W+
Sbjct: 650 VISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVT-WHKRGGSLP 708
Query: 962 -HNKKEIS--GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPE 1018
H++ S + H G + V+ I ++ + P
Sbjct: 709 SHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP 768
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
+ V E L+ + + A V W + G + P +++ H L +
Sbjct: 769 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL-PARHQV------HGPLLRLN 821
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTV-VELPPE-------------IITRLQNQKVNKGNK 1123
S D GEYSC + S T E +V V + P I + V +G
Sbjct: 822 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 881
Query: 1124 ATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ + A V W+K G + + H +L+++ D+GEY C +
Sbjct: 882 LDLNCVVPGQAHAQVTWYKRGGSLP-ARH-----QTHGSQLRLHLVSPADSGEYVCRAAS 935
Query: 1183 S---KCTAILTVEEP---SINFTLRLPEFILVPANT------DAYLTVEIPD--ETLDVT 1228
+ A TV P ++ LR P + P ++ DA I D + +
Sbjct: 936 GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLE 995
Query: 1229 WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
W + +ED + + + I + Y CV +A + V + V P
Sbjct: 996 WKTRNQELEDNVHISPNGSI----ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 1051
Query: 1288 PKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
P + V E +K G VTL P+ + W S K + + A L
Sbjct: 1052 PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQ 1111
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPEN 1406
I + +DAG Y +N G A ++ V + PG P + + + + + +
Sbjct: 1112 ISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV-QAEEAELTV------E 1164
Query: 1407 TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
G++ + T W +++ Q ++ T R + I +A+
Sbjct: 1165 AGHTATLRCSATGSPAPTIHWSKLRSPLPWQYRLEG-DTLIIPRVAQQDSGQY-ICNATS 1222
Query: 1467 TTEYYKVIKETKIQSPTVEKPL-KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
+ + ++SP + ++ + + E ++L C+ G P W R G L
Sbjct: 1223 PAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL-PG 1281
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+AT N Y+C N G E + +Q P
Sbjct: 1282 RATARNE-LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP 1326
Score = 79.0 bits (186), Expect = 2e-13
Identities = 230/1136 (20%), Positives = 397/1136 (34%), Gaps = 158/1136 (13%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQ 704
V EG + L C + + W +G + P + + S L++ V
Sbjct: 2 VTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----------HGSRLRLPQVSPAD 51
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-----------IEPLKSMIVRQGESVI 753
G Y N G I + + G P IEP S + +G+++
Sbjct: 52 SGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA-EGQTLD 110
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDEGVYTLKAENSEG 812
L+ V G +TW K +LP + TH S+ L D G Y + G
Sbjct: 111 LNCVVPGQAHAQVTWHKRGG---SLPARHQ--THGSLLRLHQVTPADSGEYVCHVVGTSG 165
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
E S ++T+E PP+ I TV E T+ L V +TWY+
Sbjct: 166 PLEASVLVTIEASVIPGPIPPVRIES-SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS 224
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-------SHGARVTIDV 925
+ + G + + S D+G Y C ASN S + GA +
Sbjct: 225 LPARHQVR----GSRLYIFQA---SPADAGQYVCRASNGMEASITVTVTGTQGANLAYPA 277
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWYH--NKKEISGMDHREIIQEGR 980
++ S + EG+T+ L C SH T W+ + H +++ +
Sbjct: 278 GSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVT-WHKRGGSLPVRHQTHGSLLRLYQ 336
Query: 981 XXXXXXX----XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAIL 1036
V + ++ E + + P + +V E L
Sbjct: 337 ASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDL 396
Query: 1037 EVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES 1095
+ + A V W + G + P +++ H +L + + D GEY C + S
Sbjct: 397 NCLVAGQAHAQVTWHKRGGSL-PARHQV------HGSRLRLLQVTPADSGEYVCRVVGSS 449
Query: 1096 CTAEVTVVELPPEIIT-----------RLQNQKVNKGNKATFEIE---LTKGDALVRWFK 1141
T E +V+ + ++ R+++ + N T ++ ++ + W+K
Sbjct: 450 GTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYK 509
Query: 1142 DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVE----- 1192
G + S H I G +L+I D+GEY C V G+ + + I+T++
Sbjct: 510 RGGSLP-SRH---QIVG--SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSS 563
Query: 1193 -EPSINFTLRLPEF--ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE-------KF 1242
PS++ +R+ +V T V +TWYK+ + +
Sbjct: 564 HVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRL 623
Query: 1243 TLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
+S + R D E + V+ + S P +I
Sbjct: 624 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 683
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
D+ +V QA Q W + T+ S L + V D+G Y R+
Sbjct: 684 LDLNCVVPGQAHAQVT--WHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCRV 735
Query: 1363 ENNCGHADVEMNVTI-------LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYY 1415
+ G + + VTI + P+P G P I I+ SS + G + +
Sbjct: 736 MGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPI-RIEPSSSRVA------EGQTLDLKC 788
Query: 1416 VVEYQEIDTTEWISVKNITKTQTSIQN--LKTN--SSYRFRAYAVNEVDISDASETTEYY 1471
VV Q W + + L+ N S Y+ S E +
Sbjct: 789 VVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLV 848
Query: 1472 KVIKET--KIQSPTVEKPL----KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
+ + I +P + +P+ + + ++L C+ G +VTWY+ G L
Sbjct: 849 TIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR 908
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQ---------QKPVITI 1575
T+ ++ Y C A + G E E S V + + PVI+I
Sbjct: 909 HQTHGSQ--LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISI 966
Query: 1576 S--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIK 1633
+ ++Q + L+ +G P + W +LE+ N+ S+I I
Sbjct: 967 DPPSSTVQQGQDASFKCLIH---DGAAPISLEWKTRNQELED----NVHISPNGSIITIV 1019
Query: 1634 ELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS---KPEGPVIMREISRESVTIE 1686
+ S+ Y ASN G + V L V+ P+ PEGPV ++ ++VT+E
Sbjct: 1020 GTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVK--VGKAVTLE 1073
Score = 78.2 bits (184), Expect = 3e-13
Identities = 158/757 (20%), Positives = 277/757 (36%), Gaps = 98/757 (12%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
+Y+ NN L+ + I P P++ SM PI +E H +G T+ C
Sbjct: 633 EYVCRANNNIDALEASI--VISVSPSAGSPSAPGSSM-PIRIES-SSSHVAEGETLDLNC 688
Query: 532 QVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGF 591
V G Q+TW ++ + PS + + L + V P D+G + C ++G
Sbjct: 689 VVPGQAHAQVTWHKRGGSL-PS------HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 741
Query: 592 ASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDI 651
++ + +EA GS G PP +P + V EG +
Sbjct: 742 LEASVLVTIEA----SGS------------SAVHVPAPGGAPP-IRIEPSSSRVAEGQTL 784
Query: 652 LLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV 711
L+C + + W +G + P + ++ +L++ V G Y+
Sbjct: 785 DLKCVVPGQAHAQVTWHKRGGNL-PARH---------QVHGPLLRLNQVSPADSGEYSCQ 834
Query: 712 AVNREGEASLPIVLKIKTGEKEP---PQVIEPL----KSMIVRQGESVILSAQVVGNPRP 764
G +++ I+ P P + +P+ S V +G+++ L+ V G
Sbjct: 835 VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHA 894
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+TW K + A ++ G + ++ P D G Y +A + G E A TV
Sbjct: 895 QVTWYKRGGSLPA-RHQTHGSQLRLHLVSP---ADSGEYVCRAASGPG-PEQEASFTVTV 949
Query: 825 PTEENA----EPPLFINRFQEITVKEKGTIKLVARVTRNPVP-SITWYRNNEIISPSETI 879
P E + P+ TV++ + P S+ W N+ + + I
Sbjct: 950 PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHI 1009
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS-Y 938
+ N G I +V T + G Y+CVASN+ G + + V + V V L +
Sbjct: 1010 SPN--GSIITIVGTRPSNH---GTYRCVASNAYGVAQ--SVVNLSVHGPPTVSVLPEGPV 1062
Query: 939 ETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
+ GK V LEC ++ S +W + ++ R D G
Sbjct: 1063 WVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGT 1122
Query: 997 IKCIVKD-----QETSTMLV----VKETIPEFIRKLQDFEVKEKDVAILEVEINSETADV 1047
C+ ++ Q+ ++V + P+ + + V+ A L A
Sbjct: 1123 YVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPT 1182
Query: 1048 V-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---V 1103
+ W + + P +Y E L I + D G+Y C + AE T+ V
Sbjct: 1183 IHWSK---LRSPLPWQYRLEG----DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHV 1235
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
E PP T ++ V G + L G +W + GS + + +
Sbjct: 1236 ESPPYATTVPEHASVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPG------RATARNE 1288
Query: 1162 KLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEP 1194
L +D+G Y C +VG+++ A L V+ P
Sbjct: 1289 LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGP 1325
Score = 74.1 bits (174), Expect = 5e-12
Identities = 232/1226 (18%), Positives = 421/1226 (34%), Gaps = 143/1226 (11%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G T+ C V G Q+TW+R+ + P + + + L + +V P D+G +
Sbjct: 4 EGQTLDLNCVVAGSAHAQVTWYRRGGSLPP-------HTQVHGSRLRLPQVSPADSGEYV 56
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
C +N +G ++ + V HG+ + G +P +
Sbjct: 57 CRVENGSGPKEASITVSVL-----HGTHSGPSYTP-----------VPGSTRPIRIEPSS 100
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKK 702
+V EG + L C + + W +G ++ + + S+L++ V
Sbjct: 101 SHVAEGQTLDLNCVVPGQAHAQVTWHKRGG----------SLPARHQTHGSLLRLHQVTP 150
Query: 703 FQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVG 760
G Y V G EAS+ + ++ P V S V +G+++ LS V G
Sbjct: 151 ADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAG 210
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+TW K +LP + + I + D G Y +A N E S +
Sbjct: 211 QAHAQVTWYKRG---GSLPARHQVRGSRLYIFQASPA-DAGQYVCRASNG---MEASITV 263
Query: 821 TVEEPTEENAEPPLFINRFQEI-----TVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
TV N P + I V E T+ L V +TW++
Sbjct: 264 TVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKR----GG 319
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID-------VEKV 928
S + G + L S DSG+Y C S+ VTI+ +
Sbjct: 320 SLPVRHQTHGSLLRLYQA---SPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVT 376
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
V+ S + EG+T+ L C + + +K+ + R + R
Sbjct: 377 PTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG-GSLPARHQVHGSR---LRLLQ 432
Query: 989 XXXXDVGVIKCIV----KDQETSTMLVVKETIPEFIRKLQDFEVK-EKDVAILEVEINSE 1043
D G C V QE S ++ +++ + + + V+ E A L +
Sbjct: 433 VTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 492
Query: 1044 TADVVWERDGEIIKPKKNKYDFEKRGHI--RKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
+V + I K R I +L I + D GEY C + + + + E +
Sbjct: 493 LNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETS 552
Query: 1102 VV------------ELPPEIITRLQNQKVNKGNKATFE-IELTKGDALVRWFKDGSEIQF 1148
++ + P I + V +G + + A++ W+K G +
Sbjct: 553 LIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLP- 611
Query: 1149 SNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTV-------EEPSIN 1197
S H L+++ + D+GEY C N+ + + +++V P +
Sbjct: 612 SRH-----QTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSS 666
Query: 1198 FTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKSVI---EDTEKFTL----ISDV 1248
+R+ A + L +P + VTW+K+ + T L +S
Sbjct: 667 MPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPA 726
Query: 1249 KKRTLIIRKCTEDDQCEYT-CVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGS--DV 1305
+ R E + V ++A ++ + V P I R+ G D+
Sbjct: 727 DSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDL 786
Query: 1306 TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENN 1365
+V QA Q W K+ + L + +V D+G Y ++ +
Sbjct: 787 KCVVPGQAHAQVT--W------HKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGS 838
Query: 1366 CGHADVEMNVTI-LDKPSP---PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
G + + VTI P P PG + I++SS ++ G + + VV Q
Sbjct: 839 SGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV------TEGQTLDLNCVVPGQA 892
Query: 1422 IDTTEWI----SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKET 1477
W S+ +T S L S Y + + + +
Sbjct: 893 HAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPS 952
Query: 1478 K-----IQSPTVEKPLKNITTEPNEDIELTC-IFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
+ ++SP + + T + +D C I G + W ++L+ N
Sbjct: 953 EGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN 1012
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y+C+A N +G ++ + + P +++ E KVG
Sbjct: 1013 GSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG-PVWVKVGKAVT 1071
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ V G P W + + ++ + +V++I K S + Y A N
Sbjct: 1072 LECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNAL 1131
Query: 1652 GTSSVEVTLKVYDKPSKPEGPVIMRE 1677
GT+ +V + V P P + E
Sbjct: 1132 GTAQKQVEVIVDTGAMAPGAPQVQAE 1157
Score = 73.3 bits (172), Expect = 9e-12
Identities = 89/415 (21%), Positives = 159/415 (38%), Gaps = 54/415 (13%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TVQ +C G P W R + + + L PED+G + C
Sbjct: 1253 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARN-------ELLHFERAAPEDSGRYRC 1305
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
N G A + +L+V+ P GS I G PT P+ +
Sbjct: 1306 RVTNKVGSAEAFAQLLVQGP---PGS-------------LPATSIPAGSTPTVQVTPQLE 1349
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
G+ + C + + + W +G ++ P ++ VL+I N+ +
Sbjct: 1350 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG----------VLRIQNLDQS 1399
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
+GTY A G+A L I+ + +++++V G +V +G+P+
Sbjct: 1400 CQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV--GHAVEFECLALGDPK 1457
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P +TW K ++ +S G + + ++ D G Y A N+ G ++ ++ V+
Sbjct: 1458 PQVTWSKVGGHLRPGIVQSGG----VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ 1513
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
A P I+ QE+ V + P P I+W + + + P +
Sbjct: 1514 ------ALPQ--ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL---- 1561
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
EN L++ +V + D+G Y C A+N GK A + + V + S+
Sbjct: 1562 --ENNMLMLPSVRPQ-DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSF 1613
Score = 57.6 bits (133), Expect = 5e-07
Identities = 147/732 (20%), Positives = 258/732 (35%), Gaps = 116/732 (15%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S PI +E H +G T+ C V G Q+TW ++ + P++ + +
Sbjct: 90 STRPIRIEP-SSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-PARH------QTHGS 141
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
L + +V P D+G + C +G ++ + +EA
Sbjct: 142 LLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEA------------------------ 177
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN------- 679
++ G P + + V EG + L C + + W +G +
Sbjct: 178 SVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLY 237
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIE 739
I A +D Y + E + TV +G L G +P + IE
Sbjct: 238 IFQASPADAGQY-----VCRASNGMEASITVTVTGTQGAN-----LAYPAGSTQPIR-IE 286
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVK 798
P S V +G+++ L+ V G +TW K +LP + TH S+ L
Sbjct: 287 PSSSQ-VAEGQTLDLNCVVPGQSHAQVTWHKRG---GSLPVRH--QTHGSLLRLYQASPA 340
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENA--EPPLFINRFQEITVKEKGTIKLVARV 856
D G Y + S E S ++T+E A P V E T+ L V
Sbjct: 341 DSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLV 400
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+TW++ + + G + L+ + DSG+Y C S+G
Sbjct: 401 AGQAHAQVTWHKRGGSLPARHQV----HGSRLRLLQV---TPADSGEYVCRVVGSSGTQE 453
Query: 917 HGARVTID-------VEKVTFVKHLQKSYET-EEGKTVILEC----QTSHTVSTKWYHNK 964
VTI + V + ++ S + G T+ L C Q HT++ WY
Sbjct: 454 ASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTIT--WY--- 508
Query: 965 KEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD----QETSTMLVVKETIPEFI 1020
K + R I R D G C V + +ETS ++ ++ + +
Sbjct: 509 KRGGSLPSRHQIVGSR---LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHV 565
Query: 1021 RKLQ-DFEVKEKDVAILEVEINSETADVVWERDGEIIKPKK-NKYDFEKRGHIRKLYIRN 1078
+ ++ ++E + V + I K+ + H L +
Sbjct: 566 PSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQ 625
Query: 1079 TSVHDEGEYSCILRDESCTAEVT-VVELPP----------EIITRLQNQKVNKGNKATFE 1127
SV D GEY C + E + V+ + P + R+++ + T +
Sbjct: 626 MSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLD 685
Query: 1128 IELT---KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV---- 1180
+ + A V W K G + S+H + +L+++ D+GEY C V
Sbjct: 686 LNCVVPGQAHAQVTWHKRGGSLP-SHH-----QTRGSRLRLHHVSPADSGEYVCRVMGSS 739
Query: 1181 GNSKCTAILTVE 1192
G + + ++T+E
Sbjct: 740 GPLEASVLVTIE 751
Score = 54.0 bits (124), Expect = 6e-06
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 49/435 (11%)
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV-------EFPPKIVDYEREYRIKRGSDV 1305
L I D Y C+ +A T + +VEV+ P++ E E ++ G
Sbjct: 1110 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTA 1169
Query: 1306 TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SIDSKSASLTIKKVENTDAGIYKLRLEN 1364
TL P P W K + P + +L I +V D+G Y +
Sbjct: 1170 TLRCSATGSPAPTIHW-------SKLRSPLPWQYRLEGDTLIIPRVAQQDSGQYICNATS 1222
Query: 1365 NCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
GHA+ + IL SPP + E +S+ G + + + T
Sbjct: 1223 PAGHAEATI---ILHVESPPYATTVPE--HASVQ--------AGETVQLQCLAHGTPPLT 1269
Query: 1425 TEWISVKNITKTQTSIQN-------LKTNSSYRFRAYAVNEVDISDASETTEYYKV---I 1474
+W V + + + +N S R+R N+V ++A +
Sbjct: 1270 FQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL 1329
Query: 1475 KETKI---QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
T I +PTV+ + T +E C ++ W+++G +L + +
Sbjct: 1330 PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG 1389
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A G+ + S + IQ P + I+ Q VG
Sbjct: 1390 --VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVE 1447
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ G P P+V W K G L + V+RI ++ + + +Y A+N A
Sbjct: 1448 FECLALGDPKPQVTWSKVGGHLRPG------IVQSGGVVRIAHVELADAGQYRCTATNAA 1501
Query: 1652 GTSSVEVTLKVYDKP 1666
GT+ V L V P
Sbjct: 1502 GTTQSHVLLLVQALP 1516
Score = 52.4 bits (120), Expect = 2e-05
Identities = 182/914 (19%), Positives = 325/914 (35%), Gaps = 139/914 (15%)
Query: 843 TVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSG 902
+V E T+ L V + +TWYR + P + G + L S DSG
Sbjct: 1 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----HGSRLRLPQV---SPADSG 53
Query: 903 DYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT--VILECQTSHTVSTKW 960
+Y C N +G A +T+ V T H SY G T + +E +SH +
Sbjct: 54 EYVCRVENGSGPKE--ASITVSVLHGT---HSGPSYTPVPGSTRPIRIEPSSSHVAEGQT 108
Query: 961 YHNKKEISGMDHREIIQEGRXXXXXXXXXXX-----------XDVGVIKCIVKDQ----E 1005
+ G H ++ R D G C V E
Sbjct: 109 LDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLE 168
Query: 1006 TSTMLVVKET-----IPEFIRKLQDFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPK 1059
S ++ ++ + IP + V E L + + A V W + G + P
Sbjct: 169 ASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL-PA 227
Query: 1060 KNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL---RDESCTAEVTVVE----LPPEIIT- 1111
++ + RG +LYI S D G+Y C + S T VT + P T
Sbjct: 228 RH----QVRG--SRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQ 281
Query: 1112 --RLQNQKVNKGNKATFEIELT---KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
R++ T ++ + A V W K G + + ++ L++Y
Sbjct: 282 PIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSL------LRLY 335
Query: 1167 DCDLDDAGEYSCEV-GNS---KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPD 1222
D+GEY C V G+S + + ++T+E L + + + +++ + D
Sbjct: 336 QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLD 395
Query: 1223 --------ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
VTW+K+ + + V L + + T D EY C ++ +
Sbjct: 396 LNCLVAGQAHAQVTWHKRGGSLPARHQ------VHGSRLRLLQVTPADSGEYVCRVVGSS 449
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI-VNSKIIKKCKH 1333
T + V V + +G + ++ + N + +N + + H
Sbjct: 450 GTQEASVLVT------IQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPH 503
Query: 1334 T------KPSIDSK----SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
T S+ S+ + L I +V D+G Y + N G + + VTI S
Sbjct: 504 TITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSS 563
Query: 1384 --PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWI----SVKNITKTQ 1437
P + I+SSS + G + + VV Q W S+ + +T
Sbjct: 564 HVPSVSPPIRIESSSPTVV------EGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH 617
Query: 1438 TS---IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTE 1494
S + + S + A N +D +AS ++ +++ ++
Sbjct: 618 GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH 677
Query: 1495 --PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIA 1552
E ++L C+ G +VTW++ G L + T +R Y C
Sbjct: 678 VAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSR--LRLHHVSPADSGEYVCRV 735
Query: 1553 FNDHGEVETSCVVGIQQK-------------PVITISNEDIKQKHKVGDEWLVTAVIEGI 1599
G +E S +V I+ P I I E + G + V+ G
Sbjct: 736 MGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRI--EPSSSRVAEGQTLDLKCVVPGQ 793
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
+V W+K G L + + ++R+ ++ + S +Y+ + + ++GT +E +
Sbjct: 794 AHAQVTWHKRGGNLPARHQVH------GPLLRLNQVSPADSGEYSCQVTGSSGT--LEAS 845
Query: 1660 LKVYDKPSKPEGPV 1673
+ V +PS P GP+
Sbjct: 846 VLVTIEPSSP-GPI 858
>M85289-1|AAA52700.1| 4391|Homo sapiens heparan sulfate proteoglycan
protein.
Length = 4391
Score = 113 bits (272), Expect = 7e-24
Identities = 178/814 (21%), Positives = 311/814 (38%), Gaps = 104/814 (12%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
PI++E H +G T+ C V G Q+TW+++ + P++ + + L
Sbjct: 2926 PIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL-PARH------QTHGSQLR 2977
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
+ V P D+G + C A + G V P S+ GS +
Sbjct: 2978 LHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSE-GSSYRLRS-------------- 3021
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDM 688
P S P + V +G D +C + P + W + +E+ ++N+ ++
Sbjct: 3022 ----PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNG-- 3073
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVR 747
S++ I + GTY VA N G A + L + PP V + P + V+
Sbjct: 3074 ----SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHG----PPTVSVLPEGPVWVK 3125
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG--DTHSITILKPKKVKDEGVYTL 805
G++V L G PR + W + + L ++ G D+H++ + K D G Y
Sbjct: 3126 VGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVC 3185
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A+N+ G A+ + V+ P + E+TV+ T L T +P P+I
Sbjct: 3186 LAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE-AELTVEAGHTATLRCSATGSPAPTIH 3244
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W +++ SP +G+ L+I V + DSG Y C A++ AG + A + + V
Sbjct: 3245 W---SKLRSPLPW-QHRLEGDT--LIIPRVAQQ-DSGQYICNATSPAGHAE--ATIILHV 3295
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXX 983
E + + + + G+TV L+C T ++ +W + G R
Sbjct: 3296 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR------ATARNEL 3349
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G +C V ++ S + + L + ++V E
Sbjct: 3350 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE 3409
Query: 1044 TADVVWERDGEIIKPKKNKYD---FEKRGHIRK--------LYIRNTSVHDEGEYSCILR 1092
T + + P F++ G + L I+N +G Y C
Sbjct: 3410 TKSIGASVEFHCAVPSDQGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3469
Query: 1093 DE----SCTAEVTVVELPPEIIT-RLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSE 1145
+A++ + LP +I R Q V G+ FE L GD V W K G
Sbjct: 3470 GPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC-LALGDPKPQVTWSKVGG- 3527
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT----AILTVEE-PSINFTL 1200
H++ I ++I +L DAG+Y C N+ T +L V+ P I+
Sbjct: 3528 -----HLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS--- 3579
Query: 1201 RLPEFILVPANTDA-YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
+P+ + VPA + A + + T D++W K + S ++ L++
Sbjct: 3580 -MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPD------SRLENNMLMLPSVR 3632
Query: 1260 EDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDY 1293
D Y C + + K ++ P ++V Y
Sbjct: 3633 PQDAGTYVCTATNRQGKVKAFAH-LQVPERVVPY 3665
Score = 98.7 bits (235), Expect = 2e-19
Identities = 260/1257 (20%), Positives = 443/1257 (35%), Gaps = 187/1257 (14%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV+ C+ G P ITW ++ + P Q + ++ATL+I + DAG + C
Sbjct: 1970 GRTVRLYCRAAGVPSATITWRKEGGSLPP----QARSERTDIATLLIPAITTADAGFYLC 2025
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA + AG A + + +V SD PP + +
Sbjct: 2026 VATSPAGTAQARMQ-VVVLSASDAS------------------------PPGVKIESSSP 2060
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG + L C + + W +G + P + + S L++ V
Sbjct: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----------HGSRLRLPQVSPA 2110
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-----------IEPLKSMIVRQGESV 752
G Y N G I + + G P IEP S V +G+++
Sbjct: 2111 DSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP-SSSHVAEGQTL 2169
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDEGVYTLKAENSE 811
L+ V G +TW K +LP + TH S+ L D G Y +
Sbjct: 2170 DLNCVVPGQAHAQVTWHKRG---GSLPARH--QTHGSLLRLHQVTPADSGEYVCHVVGTS 2224
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
G E S ++T+E PP+ I TV E T+ L V +TWY+
Sbjct: 2225 GPLEASVLVTIEASVIPGPIPPVRIES-SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGG 2283
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-------SHGARVTID 924
+ + G + + S D+G Y C ASN S + GA +
Sbjct: 2284 SLPARHQVR----GSRLYIFQA---SPADAGQYVCRASNGMEASITVTVTGTQGANLAYP 2336
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWYH--NKKEISGMDHREIIQEG 979
++ S + EG+T+ L C SH T W+ + H +++
Sbjct: 2337 AGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVT-WHKRGGSLPVRHQTHGSLLRLY 2395
Query: 980 RXXXXXXX----XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAI 1035
+ V + ++ E + + P + +V E
Sbjct: 2396 QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLD 2455
Query: 1036 LEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
L + + A V W + G + P +++ H +L + + D GEY C +
Sbjct: 2456 LNCLVAGQAHAQVTWHKRGGSL-PARHQV------HGSRLRLLQVTPADSGEYVCRVVGS 2508
Query: 1095 SCTAEVTVVELPPEIIT-----------RLQNQKVNKGNKATFEIE---LTKGDALVRWF 1140
S T E +V+ + ++ R+++ + N T ++ ++ + W+
Sbjct: 2509 SGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWY 2568
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVE---- 1192
K G + S H I G +L+I D+GEY C V G+ + + I+T++
Sbjct: 2569 KRGGSLP-SRH---QIVG--SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS 2622
Query: 1193 --EPSINFTLRLPEF--ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE-------K 1241
PS++ +R+ +V T V +TWYK+ + +
Sbjct: 2623 SHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLR 2682
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKR 1301
+S + R D E + V+ + S P +I
Sbjct: 2683 LHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGE 2742
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
D+ +V QA Q W + T+ S L + V D+G Y R
Sbjct: 2743 TLDLNCVVPGQAHAQVT--WHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCR 2794
Query: 1362 LENNCGHADVEMNVTI-------LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
+ + G + + VTI + P+P G P I I+ SS + G + +
Sbjct: 2795 VMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPI-RIEPSSSRVA------EGQTLDLK 2847
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQN--LKTN--SSYRFRAYAVNEVDISDASETTEY 1470
VV Q W + + L+ N S Y+ S E +
Sbjct: 2848 CVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
Query: 1471 YKVIKET--KIQSPTVEKPL----KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
+ + I +P + +P+ + + ++L C+ G +VTWY+ G L
Sbjct: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA 2967
Query: 1525 AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQ---------QKPVIT 1574
T+ ++ Y C A + G E E S V + + PVI+
Sbjct: 2968 RHQTHGSQ--LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVIS 3025
Query: 1575 IS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
I + ++Q + L+ +G P + W +LE+ N+ S+I I
Sbjct: 3026 IDPPSSTVQQGQDASFKCLIH---DGAAPISLEWKTRNQELED----NVHISPNGSIITI 3078
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS---KPEGPVIMREISRESVTIE 1686
+ S+ Y ASN G + V L V+ P+ PEGPV ++ ++VT+E
Sbjct: 3079 VGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVK--VGKAVTLE 3133
Score = 90.6 bits (215), Expect = 5e-17
Identities = 263/1242 (21%), Positives = 449/1242 (36%), Gaps = 186/1242 (14%)
Query: 505 EQSMAPIFVEKLRPKHT--PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
E + AP+ VE + P + P G + CQV G P W R+ PS Q +
Sbjct: 1671 ETNQAPLVVE-VHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS 1729
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDHGSEMTVXXXXXXXX 621
+ L V P DAG + C +N +S EL+V EAP +TV
Sbjct: 1730 E----LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAP----SKPITV-----TVE 1776
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G TF K++ + L+ RL P A F G I+ N+
Sbjct: 1777 EQRSQSVRPGADVTFICTAKSK---SPAYTLVWTRLHNGKLPTRAMDFNG--ILTIRNVQ 1831
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL 741
+ SD Y V +N+ +GT T + V G S P+V PPQ
Sbjct: 1832 L---SDAGTY--VCTGSNMFAMDQGTAT-LHVQASGTLSAPVV------SIHPPQ----- 1874
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDE 800
+ V+ G+ G+P PT+ W P LP K+ H I L + D+
Sbjct: 1875 --LTVQPGQLAEFRCSATGSPTPTLEW--TGGPGGQLPAKA--QIHGGILRLPAVEPTDQ 1928
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
Y +A +S G AV+ V P + ++ + V T++L R P
Sbjct: 1929 AQYLCRAHSSAGQQVARAVLHV----HGGGGPRVQVSP-ERTQVHAGRTVRLYCRAAGVP 1983
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ITW + + P + +I ++ + D+G Y CVA++ AG + +
Sbjct: 1984 SATITWRKEGGSLPPQ----ARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARMQ 2039
Query: 921 VTI---DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREI 975
V + VK S EG+T+ L C + + + WY + H ++
Sbjct: 2040 VVVLSASDASPPGVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLP--PHTQV 2097
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKD----QETS-TMLVVKET--------IPEFIRK 1022
D G C V++ +E S T+ V+ T +P R
Sbjct: 2098 ----HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRP 2153
Query: 1023 LQ----DFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
++ V E L + + A V W + G + P ++ + G + +L+
Sbjct: 2154 IRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-PARH----QTHGSLLRLH-- 2206
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTV-VELPPEII------TRLQNQKVNKGNKATFEIEL 1130
+ D GEY C + S E +V V + +I R+++ T ++
Sbjct: 2207 QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC 2266
Query: 1131 T---KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
+ A V W+K G + + + + +L I+ DAG+Y C N +
Sbjct: 2267 VVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQASPADAGQYVCRASNGMEAS 2320
Query: 1188 ILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD------------VTWYKKKSV 1235
I + L P P + + +TLD VTW+K+
Sbjct: 2321 ITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGG- 2379
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP-------- 1287
+ L + + + D EY C +L + + V V P
Sbjct: 2380 -----SLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALG 2434
Query: 1288 --PKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA 1343
P + ++ G D+ LV QA Q W + +H +
Sbjct: 2435 VTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVT--WHKRGGSL-PARH-----QVHGS 2486
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI---LEIDSSSINIC 1400
L + +V D+G Y R+ + G + + VTI + S + + I+SSS ++
Sbjct: 2487 RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLA 2546
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI-------SVKNITKTQTSIQNLKTNSSYRFRA 1453
G++ + +V Q T W S I ++ I + S +
Sbjct: 2547 ------NGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVC 2600
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP----NEDIELTCIFGGVP 1509
+ N + + ET+ + P+V P++ ++ P + ++L C+ P
Sbjct: 2601 HVSNG---AGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQP 2657
Query: 1510 QPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ 1569
Q +TWY+ G L + T+ + Y C A N+ +E S V+ +
Sbjct: 2658 QAIITWYKRGGSLPSRHQTHGSH--LRLHQMSVADSGEYVCRANNNIDALEASIVISVSP 2715
Query: 1570 ---KPVITISNEDIK----QKHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
P S+ I+ H E L + V+ G +V W+K G L + +
Sbjct: 2716 SAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQ--- 2772
Query: 1622 TTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLK 1661
+ S +R+ + + S +Y ++G +SV VT++
Sbjct: 2773 ---TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
Score = 87.8 bits (208), Expect = 4e-16
Identities = 205/1006 (20%), Positives = 354/1006 (35%), Gaps = 118/1006 (11%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ PT + + V EG + L C + + W +G ++ + +
Sbjct: 2434 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGG----------SLPARHQV 2483
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLK----SM 744
+ S L++ V G Y V G EAS+ + ++ + V P++ S
Sbjct: 2484 HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSA 2543
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD--GDTHSITILKPKKVKDEGV 802
+ G ++ L+ V TITW K +LP++ G I + P D G
Sbjct: 2544 SLANGHTLDLNCLVASQAPHTITWYKRG---GSLPSRHQIVGSRLRIPQVTP---ADSGE 2597
Query: 803 YTLKAENSEGIAETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRN 859
Y N G ETS ++T++ + PP+ I TV E T+ L V R
Sbjct: 2598 YVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES-SSPTVVEGQTLDLNCVVARQ 2656
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P ITWY+ + PS T G ++ L + S DSG+Y C A+N+
Sbjct: 2657 PQAIITWYKRGGSL-PSRHQTH---GSHLRL---HQMSVADSGEYVCRANNNIDALEASI 2709
Query: 920 RVTIDVE--------KVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWY------- 961
+++ ++ S EG+T+ L C +H T W+
Sbjct: 2710 VISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVT-WHKRGGSLP 2768
Query: 962 -HNKKEIS--GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPE 1018
H++ S + H G + V+ I ++ + P
Sbjct: 2769 SHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP 2828
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
+ V E L+ + + A V W + G + P +++ H L +
Sbjct: 2829 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL-PARHQV------HGPLLRLN 2881
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTV-VELPPE-------------IITRLQNQKVNKGNK 1123
S D GEYSC + S T E +V V + P I + V +G
Sbjct: 2882 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2941
Query: 1124 ATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ + A V W+K G + + H +L+++ D+GEY C +
Sbjct: 2942 LDLNCVVPGQAHAQVTWYKRGGSLP-ARH-----QTHGSQLRLHLVSPADSGEYVCRAAS 2995
Query: 1183 S---KCTAILTVEEP---SINFTLRLPEFILVPANT------DAYLTVEIPD--ETLDVT 1228
+ A TV P ++ LR P + P ++ DA I D + +
Sbjct: 2996 GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLE 3055
Query: 1229 WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
W + +ED + + + I + Y CV +A + V + V P
Sbjct: 3056 WKTRNQELEDNVHISPNGSI----ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
Query: 1288 PKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
P + V E +K G VTL P+ + W S K + + A L
Sbjct: 3112 PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQ 3171
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPEN 1406
I + +DAG Y +N G A ++ V + PG P + + + + + +
Sbjct: 3172 ISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV-QAEEAELTV------E 3224
Query: 1407 TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
G++ + T W +++ Q ++ T R + I +A+
Sbjct: 3225 AGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG-DTLIIPRVAQQDSGQY-ICNATS 3282
Query: 1467 TTEYYKVIKETKIQSPTVEKPL-KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
+ + ++SP + ++ + + E ++L C+ G P W R G L
Sbjct: 3283 PAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL-PG 3341
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+AT N Y+C N G E + +Q P
Sbjct: 3342 RATARNE-LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP 3386
Score = 77.4 bits (182), Expect = 5e-13
Identities = 158/752 (21%), Positives = 274/752 (36%), Gaps = 88/752 (11%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
+Y+ NN L+ + I P P++ SM PI +E H +G T+ C
Sbjct: 2693 EYVCRANNNIDALEASI--VISVSPSAGSPSAPGSSM-PIRIES-SSSHVAEGETLDLNC 2748
Query: 532 QVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGF 591
V G Q+TW ++ + PS + + L + V P D+G + C ++G
Sbjct: 2749 VVPGQAHAQVTWHKRGGSL-PS------HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2801
Query: 592 ASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDI 651
++ + +EA GS G PP +P + V EG +
Sbjct: 2802 LEASVLVTIEA----SGS------------SAVHVPAPGGAPP-IRIEPSSSRVAEGQTL 2844
Query: 652 LLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV 711
L+C + + W +G + P + ++ +L++ V G Y+
Sbjct: 2845 DLKCVVPGQAHAQVTWHKRGGNL-PARH---------QVHGPLLRLNQVSPADSGEYSCQ 2894
Query: 712 AVNREGEASLPIVLKIKTGEKEP---PQVIEPL----KSMIVRQGESVILSAQVVGNPRP 764
G +++ I+ P P + +P+ S V +G+++ L+ V G
Sbjct: 2895 VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHA 2954
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+TW K + A ++ G + ++ P D G Y +A + G E A TV
Sbjct: 2955 QVTWYKRGGSLPA-RHQTHGSQLRLHLVSP---ADSGEYVCRAASGPG-PEQEASFTVTV 3009
Query: 825 PTEENA----EPPLFINRFQEITVKEKGTIKLVARVTRNPVP-SITWYRNNEIISPSETI 879
P E + P+ TV++ + P S+ W N+ + + I
Sbjct: 3010 PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHI 3069
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS-Y 938
+ N G I +V T + G Y+CVASN+ G + + V + V V L +
Sbjct: 3070 SPN--GSIITIVGTRPSNH---GTYRCVASNAYGVAQ--SVVNLSVHGPPTVSVLPEGPV 3122
Query: 939 ETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
+ GK V LEC ++ S +W + ++ R D G
Sbjct: 3123 WVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGT 3182
Query: 997 IKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
C+ ++ + V E I + + + A L VE TA + G
Sbjct: 3183 YVCLAQNALGTAQKQV-EVIVDTGAMAPGAPQVQAEEAELTVEA-GHTATLRCSATGSPA 3240
Query: 1057 -----KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPE 1108
++ ++ R L I + D G+Y C + AE T+ VE PP
Sbjct: 3241 PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY 3300
Query: 1109 IITRLQNQKVNKGNKATFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T ++ V G + L G +W + GS + + + L
Sbjct: 3301 ATTVPEHASVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPG------RATARNELLHFE 3353
Query: 1167 DCDLDDAGEYSC----EVGNSKCTAILTVEEP 1194
+D+G Y C +VG+++ A L V+ P
Sbjct: 3354 RAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGP 3385
Score = 76.2 bits (179), Expect = 1e-12
Identities = 236/1247 (18%), Positives = 430/1247 (34%), Gaps = 144/1247 (11%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
++ + S + +E P T +G T+ C V G Q+TW+R+ + P +
Sbjct: 2044 SASDASPPGVKIESSSPSVT-EGQTLDLNCVVAGSAHAQVTWYRRGGSLPP-------HT 2095
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
+ + L + +V P D+G + C +N +G ++ + V HG+
Sbjct: 2096 QVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVL-----HGTHSGPSYTP---- 2146
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G +P + +V EG + L C + + W +G
Sbjct: 2147 -------VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG--------- 2190
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIE 739
++ + + S+L++ V G Y V G EAS+ + ++ P V
Sbjct: 2191 -SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRI 2249
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
S V +G+++ LS V G +TW K +LP + + I + D
Sbjct: 2250 ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRG---GSLPARHQVRGSRLYIFQASPA-D 2305
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-----TVKEKGTIKLVA 854
G Y +A N E S +TV N P + I V E T+ L
Sbjct: 2306 AGQYVCRASNG---MEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNC 2362
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
V +TW++ S + G + L S DSG+Y C S+
Sbjct: 2363 VVPGQSHAQVTWHKR----GGSLPVRHQTHGSLLRLYQA---SPADSGEYVCRVLGSSVP 2415
Query: 915 SSHGARVTID-------VEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEI 967
VTI+ + V+ S + EG+T+ L C + + +K+
Sbjct: 2416 LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG- 2474
Query: 968 SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV----KDQETSTMLVVKETIPEFIRKL 1023
+ R + R D G C V QE S ++ +++ + +
Sbjct: 2475 GSLPARHQVHGSR---LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQG 2531
Query: 1024 QDFEVK-EKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHI--RKLYIRNTS 1080
+ V+ E A L + +V + I K R I +L I +
Sbjct: 2532 VAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVT 2591
Query: 1081 VHDEGEYSCILRDESCTAEVTVV------------ELPPEIITRLQNQKVNKGNKATFE- 1127
D GEY C + + + + E +++ + P I + V +G
Sbjct: 2592 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC 2651
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS---- 1183
+ + A++ W+K G + S H L+++ + D+GEY C N+
Sbjct: 2652 VVARQPQAIITWYKRGGSLP-SRH-----QTHGSHLRLHQMSVADSGEYVCRANNNIDAL 2705
Query: 1184 KCTAILTV-------EEPSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKS 1234
+ + +++V P + +R+ A + L +P + VTW+K+
Sbjct: 2706 EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGG 2765
Query: 1235 VI---EDTEKFTL----ISDVKKRTLIIRKCTEDDQCEYT-CVLLDAKSTTKLKVEVVEF 1286
+ T L +S + R E + V ++A ++ + V
Sbjct: 2766 SLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2825
Query: 1287 PPKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P I R+ G D+ +V QA Q W K+ +
Sbjct: 2826 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT--W------HKRGGNLPARHQVHGPL 2877
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTI-LDKPSP---PGKPNILEIDSSSINIC 1400
L + +V D+G Y ++ + G + + VTI P P PG + I++SS ++
Sbjct: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV- 2936
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI----SVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
G + + VV Q W S+ +T S L S Y
Sbjct: 2937 -----TEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVC 2991
Query: 1457 NEVDISDASETTEYYKVIKETK-----IQSPTVEKPLKNITTEPNEDIELTC-IFGGVPQ 1510
+ + + ++ ++SP + + T + +D C I G
Sbjct: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
+ W ++L+ N Y+C+A N +G ++ + +
Sbjct: 3052 ISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
Query: 1571 PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVI 1630
P +++ E KVG + V G P W + + ++ + +V+
Sbjct: 3112 PTVSVLPEG-PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVL 3170
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
+I K S + Y A N GT+ +V + V P P + E
Sbjct: 3171 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE 3217
Score = 73.7 bits (173), Expect = 6e-12
Identities = 246/1313 (18%), Positives = 455/1313 (34%), Gaps = 176/1313 (13%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G T+ C V G Q+TW+++ + + + L I + P DAG +
Sbjct: 2258 EGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRG-------SRLYIFQASPADAGQYV 2310
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
C A N G +S T + G+ + G +P +
Sbjct: 2311 CRASN--GMEASITVTVT----GTQGANLAYPA---------------GSTQPIRIEPSS 2349
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKK 702
V EG + L C + + W +G S+ + H S+L++
Sbjct: 2350 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGG--------SLPVRHQTHG--SLLRLYQASP 2399
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL-----KSMIVRQGESVILSAQ 757
G Y + +++ I+ P + P S V +G+++ L+
Sbjct: 2400 ADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCL 2459
Query: 758 VVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETS 817
V G +TW K +LP + + +L+ D G Y + S G E S
Sbjct: 2460 VAGQAHAQVTWHKRGG---SLPARHQVHGSRLRLLQVTPA-DSGEYVCRVVGSSGTQEAS 2515
Query: 818 AVITVEEPTE-ENAEPPLFINRFQE--ITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
++T+++ +++ + R + ++ T+ L V +ITWY+ +
Sbjct: 2516 VLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP 2575
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID------VEKV 928
I + L I V + DSG+Y C SN AG VTI V V
Sbjct: 2576 SRHQIVGS------RLRIPQV-TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSV 2628
Query: 929 TFVKHLQKSYETE-EGKTVILECQTSHTVST--KWYHNKKEISGM-----DHREIIQEGR 980
+ ++ S T EG+T+ L C + WY + H + Q
Sbjct: 2629 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSV 2688
Query: 981 XXXXXXXXXXXXDVGVIKC---IVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILE 1037
++ ++ I + ++P I + + + +
Sbjct: 2689 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNC 2748
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
V A V W + G + P + + RG +L + + S D GEY C + S
Sbjct: 2749 VVPGQAHAQVTWHKRGGSL-PSHH----QTRGS--RLRLHHVSPADSGEYVCRVMGSSGP 2801
Query: 1098 AEVTV-----------VELP-----PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWF 1140
E +V V +P P I + +V +G + + + A V W
Sbjct: 2802 LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWH 2861
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT---AILTVEEPSIN 1197
K G + + + + L++ D+GEYSC+V S T ++L EPS
Sbjct: 2862 KRGGNLPARHQVHGPL------LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2915
Query: 1198 FTLRLPEF---ILVPANTDAY-------LTVEIPDET-LDVTWYKKKSVIEDTE------ 1240
+ P I + A++ L +P + VTWYK+ +
Sbjct: 2916 GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ 2975
Query: 1241 -KFTLISDVKKRTLIIRKCT---EDDQCEYTCVLLDAK-STTKLKVEVVEFPPKIVDYER 1295
+ L+S + R + + + +T + ++ S+ +L+ V+ P
Sbjct: 2976 LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPP------ 3029
Query: 1296 EYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT 1353
+++G D + L+ A P + EW ++ ++ H P+ + +TI +
Sbjct: 3030 SSTVQQGQDASFKCLIHDGAAPI-SLEWKTRNQELEDNVHISPN----GSIITIVGTRPS 3084
Query: 1354 DAGIYKLRLENNCGHADVEMNVTILDKPSP---PGKPNILEIDSSSINICWD--EPENTG 1408
+ G Y+ N G A +N+++ P+ P P +++ + C EP ++
Sbjct: 3085 NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSA 3144
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETT 1468
T I E T + + + I + K + + + A N + A +
Sbjct: 3145 RWTRISSTPAKLEQRTYGLMDSHAVLQ----ISSAKPSDAGTYVCLAQNA--LGTAQKQV 3198
Query: 1469 EYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT 1528
E +P V+ +T E L C G P P + W KL+ +
Sbjct: 3199 EVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHW----SKLR-SPLP 3253
Query: 1529 YENRXXXXXX---XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHK 1585
+++R Y C A + G E + ++ ++ P T E +
Sbjct: 3254 WQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASV--Q 3311
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
G+ + + G PP W + G+ L + ++ + S +Y
Sbjct: 3312 AGETVQLQCLAHGTPPLTFQWSRVGSSLPG------RATARNELLHFERAAPEDSGRYRC 3365
Query: 1646 EASNTAGTSSVEVTLKVYDKP-SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+N G++ L V P S P + VT + + +E A+
Sbjct: 3366 RVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEF-HCAVP 3424
Query: 1705 KHEPDNNRWIKVA---DVDRDVE--TYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
+ RW K V+ IQ L+++C+ + A P G ++A
Sbjct: 3425 SDQGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQA 3477
Score = 73.7 bits (173), Expect = 6e-12
Identities = 89/415 (21%), Positives = 159/415 (38%), Gaps = 54/415 (13%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TVQ +C G P W R + + + L PED+G + C
Sbjct: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARN-------ELLHFERAAPEDSGRYRC 3365
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
N G A + +L+V+ P GS I G PT P+ +
Sbjct: 3366 RVTNKVGSAEAFAQLLVQGP---PGS-------------LPATSIPAGSTPTVQVTPQLE 3409
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
G+ + C + + + W +G ++ P ++ VL+I N+ +
Sbjct: 3410 TKSIGASVEFHCAVPSDQGTQLRWFKEGGQLPPGHSVQDG----------VLRIQNLDQS 3459
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
+GTY A G+A L I+ + +++++V G +V +G+P+
Sbjct: 3460 CQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV--GHAVEFECLALGDPK 3517
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P +TW K ++ +S G + + ++ D G Y A N+ G ++ ++ V+
Sbjct: 3518 PQVTWSKVGGHLRPGIVQSGG----VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ 3573
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
A P I+ QE+ V + P P I+W + + + P +
Sbjct: 3574 ------ALPQ--ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL---- 3621
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
EN L++ +V + D+G Y C A+N GK A + + V + S+
Sbjct: 3622 --ENNMLMLPSVRPQ-DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSF 3673
Score = 72.1 bits (169), Expect = 2e-11
Identities = 216/1116 (19%), Positives = 390/1116 (34%), Gaps = 139/1116 (12%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P P+ V G + L CR +P I W +G + P + +D+ +
Sbjct: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDI----A 2008
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPI-VLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I + G Y VA + G A + V+ + + PP V S V +G+++
Sbjct: 2009 TLLIPAITTADAGFYLCVATSPAGTAQARMQVVVLSASDASPPGVKIESSSPSVTEGQTL 2068
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKAENSE 811
L+ V G+ +TW + +LP + H + P+ D G Y + EN
Sbjct: 2069 DLNCVVAGSAHAQVTWYRRG---GSLPPHT--QVHGSRLRLPQVSPADSGEYVCRVENGS 2123
Query: 812 GIAETSAVITVEEPTEE--------NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
G E S ++V T + P+ I V E T+ L V
Sbjct: 2124 GPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP-SSSHVAEGQTLDLNCVVPGQAHAQ 2182
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+TW++ + P+ T L+ + + DSG+Y C ++G VTI
Sbjct: 2183 VTWHKRGGSL-PARHQTHG------SLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
Query: 924 DVE----KVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQ 977
+ + V+ S EG+T+ L C + + WY K + R ++
Sbjct: 2236 EASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY---KRGGSLPARHQVR 2292
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKD-QETSTMLVVKET----IPEFIRKLQDFEVKEKD 1032
R D G C + E S + V T + Q ++
Sbjct: 2293 GSR---LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSS 2349
Query: 1033 VAILE---VEIN-----SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ E +++N A V W + G + P ++ + G + +LY S D
Sbjct: 2350 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL-PVRH----QTHGSLLRLY--QASPADS 2402
Query: 1085 GEYSCILRDESCTAEVTVV-------ELPPEIIT---RLQNQKVNKGNKATFEIE-LTKG 1133
GEY C + S E +V+ +P +T R+++ T ++ L G
Sbjct: 2403 GEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG 2462
Query: 1134 D--ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTA 1187
A V W K G + + + +L++ D+GEY C V G + +
Sbjct: 2463 QAHAQVTWHKRGGSLPARHQVH------GSRLRLLQVTPADSGEYVCRVVGSSGTQEASV 2516
Query: 1188 ILTVEE-------PSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKSVIED 1238
++T+++ + + +R+ AN L + + +TWYK+ +
Sbjct: 2517 LVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS 2576
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV---EFPPKIVDYER 1295
+ V R L I + T D EY C + + + + + V +
Sbjct: 2577 RHQI-----VGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
Query: 1296 EYRIKRGSDVTL---LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
RI+ S + +D + I+ K+ + + L + ++
Sbjct: 2631 PIRIESSSPTVVEGQTLDLNCVVARQPQAIIT--WYKRGGSLPSRHQTHGSHLRLHQMSV 2688
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTI---LDKPSPPGKPNILEIDSSSINICWDEPENTGN 1409
D+G Y R NN + + +++ PS PG + I+SSS ++ E E
Sbjct: 2689 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA--EGETLDL 2746
Query: 1410 STIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ ++ Q S+ + +T+ S L S Y + S E +
Sbjct: 2747 NCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASV 2806
Query: 1470 YYKV----IKETKIQSPTVEKPLK----NITTEPNEDIELTCIFGGVPQPKVTWYRDGKK 1521
+ + +P P++ + + ++L C+ G +VTW++ G
Sbjct: 2807 LVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGN 2866
Query: 1522 LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK 1581
L + Y C G +E S +V I+ I +
Sbjct: 2867 LPARHQVH--GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLA 2924
Query: 1582 Q--------KHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
Q H + L + V+ G +V WYK G L + + S +R+
Sbjct: 2925 QPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH------GSQLRL 2978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + S +Y A++ G E + V PS+
Sbjct: 2979 HLVSPADSGEYVCRAASGPGPEQ-EASFTVTVPPSE 3013
Score = 53.6 bits (123), Expect = 7e-06
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 49/435 (11%)
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV-------EFPPKIVDYEREYRIKRGSDV 1305
L I D Y C+ +A T + +VEV+ P++ E E ++ G
Sbjct: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTA 3229
Query: 1306 TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SIDSKSASLTIKKVENTDAGIYKLRLEN 1364
TL P P W K + P + +L I +V D+G Y +
Sbjct: 3230 TLRCSATGSPAPTIHW-------SKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATS 3282
Query: 1365 NCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
GHA+ + IL SPP + E +S+ G + + + T
Sbjct: 3283 PAGHAEATI---ILHVESPPYATTVPE--HASVQ--------AGETVQLQCLAHGTPPLT 3329
Query: 1425 TEWISVKNITKTQTSIQN-------LKTNSSYRFRAYAVNEVDISDASETTEYYKV---I 1474
+W V + + + +N S R+R N+V ++A +
Sbjct: 3330 FQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL 3389
Query: 1475 KETKI---QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
T I +PTV+ + T +E C ++ W+++G +L + +
Sbjct: 3390 PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDQGTQLRWFKEGGQLPPGHSVQDG 3449
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A G+ + S + IQ P + I+ Q VG
Sbjct: 3450 --VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVE 3507
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ G P P+V W K G L + V+RI ++ + + +Y A+N A
Sbjct: 3508 FECLALGDPKPQVTWSKVGGHLRPG------IVQSGGVVRIAHVELADAGQYRCTATNAA 3561
Query: 1652 GTSSVEVTLKVYDKP 1666
GT+ V L V P
Sbjct: 3562 GTTQSHVLLLVQALP 3576
Score = 46.4 bits (105), Expect = 0.001
Identities = 27/78 (34%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV F C G P P I W I PS + TL+IR+V D G +TC
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTC 479
Query: 584 VAKNAAGFASSTTELIVE 601
A NA G + ++E
Sbjct: 480 EAMNARGMVFGIPDGVLE 497
Score = 44.8 bits (101), Expect = 0.003
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 3/83 (3%)
Query: 734 PPQVIEPLKSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKALP--TKSDGDTHSIT 790
PPQV+ P + I +G++V + +G P P I W N + + P T +
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
Query: 791 ILKPKKVKDEGVYTLKAENSEGI 813
I++ K D+G YT +A N+ G+
Sbjct: 465 IIRDVKESDQGAYTCEAMNARGM 487
Score = 42.3 bits (95), Expect = 0.018
Identities = 28/108 (25%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 1550 CIAFNDHGEVETSCV-----VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV 1604
CI + H + E+ C G V+T E I+ G T V G+P P +
Sbjct: 381 CIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR--GQTVTFTCVAIGVPTPII 438
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
W N + + +T++ + I+++K S YT EA N G
Sbjct: 439 NWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 35.9 bits (79), Expect = 1.6
Identities = 19/82 (23%), Positives = 39/82 (47%), Gaps = 2/82 (2%)
Query: 1105 LPPEIITRLQNQ-KVNKGNKATFE-IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
+PP+++T + + ++G TF + + ++ W + I + +T +G +
Sbjct: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
Query: 1163 LKIYDCDLDDAGEYSCEVGNSK 1184
L I D D G Y+CE N++
Sbjct: 464 LIIRDVKESDQGAYTCEAMNAR 485
Score = 35.5 bits (78), Expect = 2.1
Identities = 66/347 (19%), Positives = 118/347 (34%), Gaps = 13/347 (3%)
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINIC 1400
+ + L V+ +DAG+Y N + + + PS P + E S S+
Sbjct: 1727 QGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPG 1786
Query: 1401 WDEPEN-TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
D T S Y + + + + + +I+N++ + + + N
Sbjct: 1787 ADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMF 1846
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
+ + T V + +P V +T +P + E C G P P + W
Sbjct: 1847 AMDQGTATLH---VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP 1903
Query: 1520 KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ--QKPVITISN 1577
AKA Y C A + G+ V+ + P + +S
Sbjct: 1904 GGQLPAKAQIHG-GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP 1962
Query: 1578 EDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKR 1637
E Q H G + G+P + W K G L + + + + I +
Sbjct: 1963 ER-TQVH-AGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITT 2017
Query: 1638 SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + Y A++ AGT+ + + V S P + E S SVT
Sbjct: 2018 ADAGFYLCVATSPAGTAQARMQVVVL-SASDASPPGVKIESSSPSVT 2063
Score = 34.7 bits (76), Expect = 3.7
Identities = 22/87 (25%), Positives = 33/87 (37%), Gaps = 5/87 (5%)
Query: 632 IPPTFSKKPKAQY-VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
+PP P+ G + C + +P P I W I ++V E
Sbjct: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR-- 461
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG 717
L I +VK+ +G YT A+N G
Sbjct: 462 --GTLIIRDVKESDQGAYTCEAMNARG 486
>AL590556-2|CAH71870.1| 4391|Homo sapiens heparan sulfate proteoglycan
2 (perlecan) protein.
Length = 4391
Score = 113 bits (272), Expect = 7e-24
Identities = 178/814 (21%), Positives = 311/814 (38%), Gaps = 104/814 (12%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
PI++E H +G T+ C V G Q+TW+++ + P++ + + L
Sbjct: 2926 PIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL-PARH------QTHGSQLR 2977
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
+ V P D+G + C A + G V P S+ GS +
Sbjct: 2978 LHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSE-GSSYRLRS-------------- 3021
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDM 688
P S P + V +G D +C + P + W + +E+ ++N+ ++
Sbjct: 3022 ----PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNG-- 3073
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVR 747
S++ I + GTY VA N G A + L + PP V + P + V+
Sbjct: 3074 ----SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHG----PPTVSVLPEGPVWVK 3125
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG--DTHSITILKPKKVKDEGVYTL 805
G++V L G PR + W + + L ++ G D+H++ + K D G Y
Sbjct: 3126 VGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVC 3185
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A+N+ G A+ + V+ P + E+TV+ T L T +P P+I
Sbjct: 3186 LAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE-AELTVEAGHTATLRCSATGSPAPTIH 3244
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W +++ SP +G+ L+I V + DSG Y C A++ AG + A + + V
Sbjct: 3245 W---SKLRSPLPW-QHRLEGDT--LIIPRVAQQ-DSGQYICNATSPAGHAE--ATIILHV 3295
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXX 983
E + + + + G+TV L+C T ++ +W + G R
Sbjct: 3296 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR------ATARNEL 3349
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G +C V ++ S + + L + ++V E
Sbjct: 3350 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE 3409
Query: 1044 TADVVWERDGEIIKPKKNKYD---FEKRGHIRK--------LYIRNTSVHDEGEYSCILR 1092
T + + P F++ G + L I+N +G Y C
Sbjct: 3410 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3469
Query: 1093 DE----SCTAEVTVVELPPEIIT-RLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSE 1145
+A++ + LP +I R Q V G+ FE L GD V W K G
Sbjct: 3470 GPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC-LALGDPKPQVTWSKVGG- 3527
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT----AILTVEE-PSINFTL 1200
H++ I ++I +L DAG+Y C N+ T +L V+ P I+
Sbjct: 3528 -----HLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS--- 3579
Query: 1201 RLPEFILVPANTDA-YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
+P+ + VPA + A + + T D++W K + S ++ L++
Sbjct: 3580 -MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPD------SRLENNMLMLPSVR 3632
Query: 1260 EDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDY 1293
D Y C + + K ++ P ++V Y
Sbjct: 3633 PQDAGTYVCTATNRQGKVKAFAH-LQVPERVVPY 3665
Score = 99.1 bits (236), Expect = 2e-19
Identities = 260/1257 (20%), Positives = 443/1257 (35%), Gaps = 187/1257 (14%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV+ C+ G P ITW ++ + P Q + ++ATL+I + DAG + C
Sbjct: 1970 GRTVRLYCRAAGVPSATITWRKEGGSLPP----QARSERTDIATLLIPAITTADAGFYLC 2025
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA + AG A + + +V SD PP + +
Sbjct: 2026 VATSPAGTAQARIQ-VVVLSASDAS------------------------PPPVKIESSSP 2060
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG + L C + + W +G + P + + S L++ V
Sbjct: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----------HGSRLRLPQVSPA 2110
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-----------IEPLKSMIVRQGESV 752
G Y N G I + + G P IEP S V +G+++
Sbjct: 2111 DSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP-SSSHVAEGQTL 2169
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDEGVYTLKAENSE 811
L+ V G +TW K +LP + TH S+ L D G Y +
Sbjct: 2170 DLNCVVPGQAHAQVTWHKRG---GSLPARH--QTHGSLLRLHQVTPADSGEYVCHVVGTS 2224
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
G E S ++T+E PP+ I TV E T+ L V +TWY+
Sbjct: 2225 GPLEASVLVTIEASVIPGPIPPVRIES-SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGG 2283
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-------SHGARVTID 924
+ + G + + S D+G Y C ASN S + GA +
Sbjct: 2284 SLPARHQVR----GSRLYIFQA---SPADAGQYVCRASNGMEASITVTVTGTQGANLAYP 2336
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWYH--NKKEISGMDHREIIQEG 979
++ S + EG+T+ L C SH T W+ + H +++
Sbjct: 2337 AGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVT-WHKRGGSLPVRHQTHGSLLRLY 2395
Query: 980 RXXXXXXX----XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAI 1035
+ V + ++ E + + P + +V E
Sbjct: 2396 QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLD 2455
Query: 1036 LEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
L + + A V W + G + P +++ H +L + + D GEY C +
Sbjct: 2456 LNCLVAGQAHAQVTWHKRGGSL-PARHQV------HGSRLRLLQVTPADSGEYVCRVVGS 2508
Query: 1095 SCTAEVTVVELPPEIIT-----------RLQNQKVNKGNKATFEIE---LTKGDALVRWF 1140
S T E +V+ + ++ R+++ + N T ++ ++ + W+
Sbjct: 2509 SGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWY 2568
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVE---- 1192
K G + S H I G +L+I D+GEY C V G+ + + I+T++
Sbjct: 2569 KRGGSLP-SRH---QIVG--SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS 2622
Query: 1193 --EPSINFTLRLPEF--ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE-------K 1241
PS++ +R+ +V T V +TWYK+ + +
Sbjct: 2623 SHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLR 2682
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKR 1301
+S + R D E + V+ + S P +I
Sbjct: 2683 LHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGE 2742
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
D+ +V QA Q W + T+ S L + V D+G Y R
Sbjct: 2743 TLDLNCVVPGQAHAQVT--WHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCR 2794
Query: 1362 LENNCGHADVEMNVTI-------LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
+ + G + + VTI + P+P G P I I+ SS + G + +
Sbjct: 2795 VMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPI-RIEPSSSRVA------EGQTLDLK 2847
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQN--LKTN--SSYRFRAYAVNEVDISDASETTEY 1470
VV Q W + + L+ N S Y+ S E +
Sbjct: 2848 CVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
Query: 1471 YKVIKET--KIQSPTVEKPL----KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
+ + I +P + +P+ + + ++L C+ G +VTWY+ G L
Sbjct: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA 2967
Query: 1525 AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQ---------QKPVIT 1574
T+ ++ Y C A + G E E S V + + PVI+
Sbjct: 2968 RHQTHGSQ--LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVIS 3025
Query: 1575 IS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
I + ++Q + L+ +G P + W +LE+ N+ S+I I
Sbjct: 3026 IDPPSSTVQQGQDASFKCLIH---DGAAPISLEWKTRNQELED----NVHISPNGSIITI 3078
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS---KPEGPVIMREISRESVTIE 1686
+ S+ Y ASN G + V L V+ P+ PEGPV ++ ++VT+E
Sbjct: 3079 VGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVK--VGKAVTLE 3133
Score = 90.6 bits (215), Expect = 5e-17
Identities = 265/1244 (21%), Positives = 452/1244 (36%), Gaps = 190/1244 (15%)
Query: 505 EQSMAPIFVEKLRPKHT--PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
E + AP+ VE + P + P G + CQV G P W R+ PS Q +
Sbjct: 1671 ETNQAPLVVE-VHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS 1729
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDHGSEMTVXXXXXXXX 621
+ L V P DAG + C +N +S EL+V EAP +TV
Sbjct: 1730 E----LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAP----SKPITV-----TVE 1776
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G TF K++ + L+ RL P A F G I+ N+
Sbjct: 1777 EQRSQSVRPGADVTFICTAKSK---SPAYTLVWTRLHNGKLPTRAMDFNG--ILTIRNVQ 1831
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL 741
+ SD Y V +N+ +GT T + V G S P+V PPQ
Sbjct: 1832 L---SDAGTY--VCTGSNMFAMDQGTAT-LHVQASGTLSAPVV------SIHPPQ----- 1874
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDE 800
+ V+ G+ G+P PT+ W P LP K+ H I L + D+
Sbjct: 1875 --LTVQPGQLAEFRCSATGSPTPTLEW--TGGPGGQLPAKA--QIHGGILRLPAVEPTDQ 1928
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
Y +A +S G AV+ V P + ++ + V T++L R P
Sbjct: 1929 AQYLCRAHSSAGQQVARAVLHV----HGGGGPRVQVSP-ERTQVHAGRTVRLYCRAAGVP 1983
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ITW + + P + +I ++ + D+G Y CVA++ AG + AR
Sbjct: 1984 SATITWRKEGGSLPPQ----ARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQ--AR 2037
Query: 921 VTIDVEKVTF-----VKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHR 973
+ + V + VK S EG+T+ L C + + + WY + H
Sbjct: 2038 IQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLP--PHT 2095
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKCIVKD----QETS-TMLVVKET--------IPEFI 1020
++ D G C V++ +E S T+ V+ T +P
Sbjct: 2096 QV----HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGST 2151
Query: 1021 RKLQ----DFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
R ++ V E L + + A V W + G + P ++ + G + +L+
Sbjct: 2152 RPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-PARH----QTHGSLLRLH 2206
Query: 1076 IRNTSVHDEGEYSCILRDESCTAEVTV-VELPPEII------TRLQNQKVNKGNKATFEI 1128
+ D GEY C + S E +V V + +I R+++ T ++
Sbjct: 2207 --QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDL 2264
Query: 1129 ELT---KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKC 1185
+ A V W+K G + + + + +L I+ DAG+Y C N
Sbjct: 2265 SCVVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQASPADAGQYVCRASNGME 2318
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD------------VTWYKKK 1233
+I + L P P + + +TLD VTW+K+
Sbjct: 2319 ASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG 2378
Query: 1234 SVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP------ 1287
+ L + + + D EY C +L + + V V P
Sbjct: 2379 G------SLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPA 2432
Query: 1288 ----PKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
P + ++ G D+ LV QA Q W + +H
Sbjct: 2433 LGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVT--WHKRGGSL-PARH-----QVH 2484
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI---LEIDSSSIN 1398
+ L + +V D+G Y R+ + G + + VTI + S + + I+SSS +
Sbjct: 2485 GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSAS 2544
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWI-------SVKNITKTQTSIQNLKTNSSYRF 1451
+ G++ + +V Q T W S I ++ I + S +
Sbjct: 2545 LA------NGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEY 2598
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP----NEDIELTCIFGG 1507
+ N + + ET+ + P+V P++ ++ P + ++L C+
Sbjct: 2599 VCHVSNG---AGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAR 2655
Query: 1508 VPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
PQ +TWY+ G L + T+ + Y C A N+ +E S V+ +
Sbjct: 2656 QPQAIITWYKRGGSLPSRHQTHGSH--LRLHQMSVADSGEYVCRANNNIDALEASIVISV 2713
Query: 1568 QQ---KPVITISNEDIK----QKHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
P S+ I+ H E L + V+ G +V W+K G L + +
Sbjct: 2714 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQ- 2772
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLK 1661
+ S +R+ + + S +Y ++G +SV VT++
Sbjct: 2773 -----TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
Score = 87.8 bits (208), Expect = 4e-16
Identities = 205/1006 (20%), Positives = 354/1006 (35%), Gaps = 118/1006 (11%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ PT + + V EG + L C + + W +G ++ + +
Sbjct: 2434 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGG----------SLPARHQV 2483
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLK----SM 744
+ S L++ V G Y V G EAS+ + ++ + V P++ S
Sbjct: 2484 HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSA 2543
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD--GDTHSITILKPKKVKDEGV 802
+ G ++ L+ V TITW K +LP++ G I + P D G
Sbjct: 2544 SLANGHTLDLNCLVASQAPHTITWYKRG---GSLPSRHQIVGSRLRIPQVTP---ADSGE 2597
Query: 803 YTLKAENSEGIAETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRN 859
Y N G ETS ++T++ + PP+ I TV E T+ L V R
Sbjct: 2598 YVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES-SSPTVVEGQTLDLNCVVARQ 2656
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P ITWY+ + PS T G ++ L + S DSG+Y C A+N+
Sbjct: 2657 PQAIITWYKRGGSL-PSRHQTH---GSHLRL---HQMSVADSGEYVCRANNNIDALEASI 2709
Query: 920 RVTIDVE--------KVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWY------- 961
+++ ++ S EG+T+ L C +H T W+
Sbjct: 2710 VISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVT-WHKRGGSLP 2768
Query: 962 -HNKKEIS--GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPE 1018
H++ S + H G + V+ I ++ + P
Sbjct: 2769 SHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP 2828
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
+ V E L+ + + A V W + G + P +++ H L +
Sbjct: 2829 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL-PARHQV------HGPLLRLN 2881
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTV-VELPPE-------------IITRLQNQKVNKGNK 1123
S D GEYSC + S T E +V V + P I + V +G
Sbjct: 2882 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2941
Query: 1124 ATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ + A V W+K G + + H +L+++ D+GEY C +
Sbjct: 2942 LDLNCVVPGQAHAQVTWYKRGGSLP-ARH-----QTHGSQLRLHLVSPADSGEYVCRAAS 2995
Query: 1183 S---KCTAILTVEEP---SINFTLRLPEFILVPANT------DAYLTVEIPD--ETLDVT 1228
+ A TV P ++ LR P + P ++ DA I D + +
Sbjct: 2996 GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLE 3055
Query: 1229 WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
W + +ED + + + I + Y CV +A + V + V P
Sbjct: 3056 WKTRNQELEDNVHISPNGSI----ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
Query: 1288 PKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
P + V E +K G VTL P+ + W S K + + A L
Sbjct: 3112 PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQ 3171
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPEN 1406
I + +DAG Y +N G A ++ V + PG P + + + + + +
Sbjct: 3172 ISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV-QAEEAELTV------E 3224
Query: 1407 TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
G++ + T W +++ Q ++ T R + I +A+
Sbjct: 3225 AGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG-DTLIIPRVAQQDSGQY-ICNATS 3282
Query: 1467 TTEYYKVIKETKIQSPTVEKPL-KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
+ + ++SP + ++ + + E ++L C+ G P W R G L
Sbjct: 3283 PAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL-PG 3341
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+AT N Y+C N G E + +Q P
Sbjct: 3342 RATARNE-LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP 3386
Score = 79.8 bits (188), Expect = 1e-13
Identities = 237/1247 (19%), Positives = 431/1247 (34%), Gaps = 144/1247 (11%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
++ + S P+ +E P T +G T+ C V G Q+TW+R+ + P +
Sbjct: 2044 SASDASPPPVKIESSSPSVT-EGQTLDLNCVVAGSAHAQVTWYRRGGSLPP-------HT 2095
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
+ + L + +V P D+G + C +N +G ++ + V HG+
Sbjct: 2096 QVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVL-----HGTHSGPSYTP---- 2146
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G +P + +V EG + L C + + W +G
Sbjct: 2147 -------VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG--------- 2190
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIE 739
++ + + S+L++ V G Y V G EAS+ + ++ P V
Sbjct: 2191 -SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRI 2249
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
S V +G+++ LS V G +TW K +LP + + I + D
Sbjct: 2250 ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRG---GSLPARHQVRGSRLYIFQASPA-D 2305
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-----TVKEKGTIKLVA 854
G Y +A N E S +TV N P + I V E T+ L
Sbjct: 2306 AGQYVCRASNG---MEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNC 2362
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
V +TW++ S + G + L S DSG+Y C S+
Sbjct: 2363 VVPGQSHAQVTWHKR----GGSLPVRHQTHGSLLRLYQA---SPADSGEYVCRVLGSSVP 2415
Query: 915 SSHGARVTID-------VEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEI 967
VTI+ + V+ S + EG+T+ L C + + +K+
Sbjct: 2416 LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG- 2474
Query: 968 SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV----KDQETSTMLVVKETIPEFIRKL 1023
+ R + R D G C V QE S ++ +++ + +
Sbjct: 2475 GSLPARHQVHGSR---LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQG 2531
Query: 1024 QDFEVK-EKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHI--RKLYIRNTS 1080
+ V+ E A L + +V + I K R I +L I +
Sbjct: 2532 VAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVT 2591
Query: 1081 VHDEGEYSCILRDESCTAEVTVV------------ELPPEIITRLQNQKVNKGNKATFE- 1127
D GEY C + + + + E +++ + P I + V +G
Sbjct: 2592 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC 2651
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS---- 1183
+ + A++ W+K G + S H L+++ + D+GEY C N+
Sbjct: 2652 VVARQPQAIITWYKRGGSLP-SRH-----QTHGSHLRLHQMSVADSGEYVCRANNNIDAL 2705
Query: 1184 KCTAILTV-------EEPSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKS 1234
+ + +++V P + +R+ A + L +P + VTW+K+
Sbjct: 2706 EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGG 2765
Query: 1235 VI---EDTEKFTL----ISDVKKRTLIIRKCTEDDQCEYT-CVLLDAKSTTKLKVEVVEF 1286
+ T L +S + R E + V ++A ++ + V
Sbjct: 2766 SLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2825
Query: 1287 PPKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P I R+ G D+ +V QA Q W K+ +
Sbjct: 2826 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT--W------HKRGGNLPARHQVHGPL 2877
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTI-LDKPSP---PGKPNILEIDSSSINIC 1400
L + +V D+G Y ++ + G + + VTI P P PG + I++SS ++
Sbjct: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV- 2936
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI----SVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
G + + VV Q W S+ +T S L S Y
Sbjct: 2937 -----TEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVC 2991
Query: 1457 NEVDISDASETTEYYKVIKETK-----IQSPTVEKPLKNITTEPNEDIELTC-IFGGVPQ 1510
+ + + ++ ++SP + + T + +D C I G
Sbjct: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
+ W ++L+ N Y+C+A N +G ++ + +
Sbjct: 3052 ISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
Query: 1571 PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVI 1630
P +++ E KVG + V G P W + + ++ + +V+
Sbjct: 3112 PTVSVLPEG-PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVL 3170
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
+I K S + Y A N GT+ +V + V P P + E
Sbjct: 3171 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE 3217
Score = 77.4 bits (182), Expect = 5e-13
Identities = 158/752 (21%), Positives = 274/752 (36%), Gaps = 88/752 (11%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
+Y+ NN L+ + I P P++ SM PI +E H +G T+ C
Sbjct: 2693 EYVCRANNNIDALEASI--VISVSPSAGSPSAPGSSM-PIRIES-SSSHVAEGETLDLNC 2748
Query: 532 QVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGF 591
V G Q+TW ++ + PS + + L + V P D+G + C ++G
Sbjct: 2749 VVPGQAHAQVTWHKRGGSL-PS------HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2801
Query: 592 ASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDI 651
++ + +EA GS G PP +P + V EG +
Sbjct: 2802 LEASVLVTIEA----SGS------------SAVHVPAPGGAPP-IRIEPSSSRVAEGQTL 2844
Query: 652 LLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV 711
L+C + + W +G + P + ++ +L++ V G Y+
Sbjct: 2845 DLKCVVPGQAHAQVTWHKRGGNL-PARH---------QVHGPLLRLNQVSPADSGEYSCQ 2894
Query: 712 AVNREGEASLPIVLKIKTGEKEP---PQVIEPL----KSMIVRQGESVILSAQVVGNPRP 764
G +++ I+ P P + +P+ S V +G+++ L+ V G
Sbjct: 2895 VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHA 2954
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+TW K + A ++ G + ++ P D G Y +A + G E A TV
Sbjct: 2955 QVTWYKRGGSLPA-RHQTHGSQLRLHLVSP---ADSGEYVCRAASGPG-PEQEASFTVTV 3009
Query: 825 PTEENA----EPPLFINRFQEITVKEKGTIKLVARVTRNPVP-SITWYRNNEIISPSETI 879
P E + P+ TV++ + P S+ W N+ + + I
Sbjct: 3010 PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHI 3069
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS-Y 938
+ N G I +V T + G Y+CVASN+ G + + V + V V L +
Sbjct: 3070 SPN--GSIITIVGTRPSNH---GTYRCVASNAYGVAQ--SVVNLSVHGPPTVSVLPEGPV 3122
Query: 939 ETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
+ GK V LEC ++ S +W + ++ R D G
Sbjct: 3123 WVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGT 3182
Query: 997 IKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
C+ ++ + V E I + + + A L VE TA + G
Sbjct: 3183 YVCLAQNALGTAQKQV-EVIVDTGAMAPGAPQVQAEEAELTVEA-GHTATLRCSATGSPA 3240
Query: 1057 -----KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPE 1108
++ ++ R L I + D G+Y C + AE T+ VE PP
Sbjct: 3241 PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY 3300
Query: 1109 IITRLQNQKVNKGNKATFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T ++ V G + L G +W + GS + + + L
Sbjct: 3301 ATTVPEHASVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPG------RATARNELLHFE 3353
Query: 1167 DCDLDDAGEYSC----EVGNSKCTAILTVEEP 1194
+D+G Y C +VG+++ A L V+ P
Sbjct: 3354 RAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGP 3385
Score = 73.7 bits (173), Expect = 6e-12
Identities = 217/1116 (19%), Positives = 390/1116 (34%), Gaps = 139/1116 (12%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P P+ V G + L CR +P I W +G + P + +D+ +
Sbjct: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDI----A 2008
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPI-VLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I + G Y VA + G A I V+ + + PP V S V +G+++
Sbjct: 2009 TLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTL 2068
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKAENSE 811
L+ V G+ +TW + +LP + H + P+ D G Y + EN
Sbjct: 2069 DLNCVVAGSAHAQVTWYRRG---GSLPPHT--QVHGSRLRLPQVSPADSGEYVCRVENGS 2123
Query: 812 GIAETSAVITVEEPTEE--------NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
G E S ++V T + P+ I V E T+ L V
Sbjct: 2124 GPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP-SSSHVAEGQTLDLNCVVPGQAHAQ 2182
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+TW++ + P+ T L+ + + DSG+Y C ++G VTI
Sbjct: 2183 VTWHKRGGSL-PARHQTHG------SLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
Query: 924 DVE----KVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQ 977
+ + V+ S EG+T+ L C + + WY K + R ++
Sbjct: 2236 EASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY---KRGGSLPARHQVR 2292
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKD-QETSTMLVVKET----IPEFIRKLQDFEVKEKD 1032
R D G C + E S + V T + Q ++
Sbjct: 2293 GSR---LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSS 2349
Query: 1033 VAILE---VEIN-----SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ E +++N A V W + G + P ++ + G + +LY S D
Sbjct: 2350 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL-PVRH----QTHGSLLRLY--QASPADS 2402
Query: 1085 GEYSCILRDESCTAEVTVV-------ELPPEIIT---RLQNQKVNKGNKATFEIE-LTKG 1133
GEY C + S E +V+ +P +T R+++ T ++ L G
Sbjct: 2403 GEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG 2462
Query: 1134 D--ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTA 1187
A V W K G + + + +L++ D+GEY C V G + +
Sbjct: 2463 QAHAQVTWHKRGGSLPARHQVH------GSRLRLLQVTPADSGEYVCRVVGSSGTQEASV 2516
Query: 1188 ILTVEE-------PSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKSVIED 1238
++T+++ + + +R+ AN L + + +TWYK+ +
Sbjct: 2517 LVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS 2576
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV---EFPPKIVDYER 1295
+ V R L I + T D EY C + + + + + V +
Sbjct: 2577 RHQI-----VGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
Query: 1296 EYRIKRGSDVTL---LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
RI+ S + +D + I+ K+ + + L + ++
Sbjct: 2631 PIRIESSSPTVVEGQTLDLNCVVARQPQAIIT--WYKRGGSLPSRHQTHGSHLRLHQMSV 2688
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTI---LDKPSPPGKPNILEIDSSSINICWDEPENTGN 1409
D+G Y R NN + + +++ PS PG + I+SSS ++ E E
Sbjct: 2689 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA--EGETLDL 2746
Query: 1410 STIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ ++ Q S+ + +T+ S L S Y + S E +
Sbjct: 2747 NCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASV 2806
Query: 1470 YYKV----IKETKIQSPTVEKPLK----NITTEPNEDIELTCIFGGVPQPKVTWYRDGKK 1521
+ + +P P++ + + ++L C+ G +VTW++ G
Sbjct: 2807 LVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGN 2866
Query: 1522 LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK 1581
L + Y C G +E S +V I+ I +
Sbjct: 2867 LPARHQVH--GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLA 2924
Query: 1582 Q--------KHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
Q H + L + V+ G +V WYK G L + + S +R+
Sbjct: 2925 QPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH------GSQLRL 2978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + S +Y A++ G E + V PS+
Sbjct: 2979 HLVSPADSGEYVCRAASGPGPEQ-EASFTVTVPPSE 3013
Score = 73.3 bits (172), Expect = 9e-12
Identities = 89/415 (21%), Positives = 159/415 (38%), Gaps = 54/415 (13%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TVQ +C G P W R + + + L PED+G + C
Sbjct: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARN-------ELLHFERAAPEDSGRYRC 3365
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
N G A + +L+V+ P GS I G PT P+ +
Sbjct: 3366 RVTNKVGSAEAFAQLLVQGP---PGS-------------LPATSIPAGSTPTVQVTPQLE 3409
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
G+ + C + + + W +G ++ P ++ VL+I N+ +
Sbjct: 3410 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG----------VLRIQNLDQS 3459
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
+GTY A G+A L I+ + +++++V G +V +G+P+
Sbjct: 3460 CQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV--GHAVEFECLALGDPK 3517
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P +TW K ++ +S G + + ++ D G Y A N+ G ++ ++ V+
Sbjct: 3518 PQVTWSKVGGHLRPGIVQSGG----VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ 3573
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
A P I+ QE+ V + P P I+W + + + P +
Sbjct: 3574 ------ALPQ--ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL---- 3621
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
EN L++ +V + D+G Y C A+N GK A + + V + S+
Sbjct: 3622 --ENNMLMLPSVRPQ-DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSF 3673
Score = 72.9 bits (171), Expect = 1e-11
Identities = 246/1313 (18%), Positives = 454/1313 (34%), Gaps = 176/1313 (13%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G T+ C V G Q+TW+++ + + + L I + P DAG +
Sbjct: 2258 EGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRG-------SRLYIFQASPADAGQYV 2310
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
C A N G +S T + G+ + G +P +
Sbjct: 2311 CRASN--GMEASITVTVT----GTQGANLAYPA---------------GSTQPIRIEPSS 2349
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKK 702
V EG + L C + + W +G S+ + H S+L++
Sbjct: 2350 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGG--------SLPVRHQTHG--SLLRLYQASP 2399
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL-----KSMIVRQGESVILSAQ 757
G Y + +++ I+ P + P S V +G+++ L+
Sbjct: 2400 ADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCL 2459
Query: 758 VVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETS 817
V G +TW K +LP + + +L+ D G Y + S G E S
Sbjct: 2460 VAGQAHAQVTWHKRGG---SLPARHQVHGSRLRLLQVTPA-DSGEYVCRVVGSSGTQEAS 2515
Query: 818 AVITVEEPTE-ENAEPPLFINRFQE--ITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
++T+++ +++ + R + ++ T+ L V +ITWY+ +
Sbjct: 2516 VLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP 2575
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID------VEKV 928
I + L I V + DSG+Y C SN AG VTI V V
Sbjct: 2576 SRHQIVGS------RLRIPQV-TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSV 2628
Query: 929 TFVKHLQKSYETE-EGKTVILECQTSHTVST--KWYHNKKEISGM-----DHREIIQEGR 980
+ ++ S T EG+T+ L C + WY + H + Q
Sbjct: 2629 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSV 2688
Query: 981 XXXXXXXXXXXXDVGVIKC---IVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILE 1037
++ ++ I + ++P I + + + +
Sbjct: 2689 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNC 2748
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
V A V W + G + P + + RG +L + + S D GEY C + S
Sbjct: 2749 VVPGQAHAQVTWHKRGGSL-PSHH----QTRGS--RLRLHHVSPADSGEYVCRVMGSSGP 2801
Query: 1098 AEVTV-----------VELP-----PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWF 1140
E +V V +P P I + +V +G + + + A V W
Sbjct: 2802 LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWH 2861
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT---AILTVEEPSIN 1197
K G + + + + L++ D+GEYSC+V S T ++L EPS
Sbjct: 2862 KRGGNLPARHQVHGPL------LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2915
Query: 1198 FTLRLPEF---ILVPANTDAY-------LTVEIPDET-LDVTWYKKKSVIEDTE------ 1240
+ P I + A++ L +P + VTWYK+ +
Sbjct: 2916 GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ 2975
Query: 1241 -KFTLISDVKKRTLIIRKCT---EDDQCEYTCVLLDAK-STTKLKVEVVEFPPKIVDYER 1295
+ L+S + R + + + +T + ++ S+ +L+ V+ P
Sbjct: 2976 LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPP------ 3029
Query: 1296 EYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT 1353
+++G D + L+ A P + EW ++ ++ H P+ + +TI +
Sbjct: 3030 SSTVQQGQDASFKCLIHDGAAPI-SLEWKTRNQELEDNVHISPN----GSIITIVGTRPS 3084
Query: 1354 DAGIYKLRLENNCGHADVEMNVTILDKPSP---PGKPNILEIDSSSINICWD--EPENTG 1408
+ G Y+ N G A +N+++ P+ P P +++ + C EP ++
Sbjct: 3085 NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSA 3144
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETT 1468
T I E T + + + I + K + + + A N + A +
Sbjct: 3145 RWTRISSTPAKLEQRTYGLMDSHAVLQ----ISSAKPSDAGTYVCLAQNA--LGTAQKQV 3198
Query: 1469 EYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT 1528
E +P V+ +T E L C G P P + W KL+ +
Sbjct: 3199 EVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHW----SKLR-SPLP 3253
Query: 1529 YENRXXXXXX---XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHK 1585
+++R Y C A + G E + ++ ++ P T E +
Sbjct: 3254 WQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASV--Q 3311
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
G+ + + G PP W + G+ L + ++ + S +Y
Sbjct: 3312 AGETVQLQCLAHGTPPLTFQWSRVGSSLPG------RATARNELLHFERAAPEDSGRYRC 3365
Query: 1646 EASNTAGTSSVEVTLKVYDKP-SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+N G++ L V P S P + VT + + +E A+
Sbjct: 3366 RVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEF-HCAVP 3424
Query: 1705 KHEPDNNRWIKVA---DVDRDVE--TYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
RW K V+ IQ L+++C+ + A P G ++A
Sbjct: 3425 SDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQA 3477
Score = 53.2 bits (122), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 49/435 (11%)
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV-------EFPPKIVDYEREYRIKRGSDV 1305
L I D Y C+ +A T + +VEV+ P++ E E ++ G
Sbjct: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTA 3229
Query: 1306 TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SIDSKSASLTIKKVENTDAGIYKLRLEN 1364
TL P P W K + P + +L I +V D+G Y +
Sbjct: 3230 TLRCSATGSPAPTIHW-------SKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATS 3282
Query: 1365 NCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
GHA+ + IL SPP + E +S+ G + + + T
Sbjct: 3283 PAGHAEATI---ILHVESPPYATTVPE--HASVQ--------AGETVQLQCLAHGTPPLT 3329
Query: 1425 TEWISVKNITKTQTSIQN-------LKTNSSYRFRAYAVNEVDISDASETTEYYKV---I 1474
+W V + + + +N S R+R N+V ++A +
Sbjct: 3330 FQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL 3389
Query: 1475 KETKI---QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
T I +PTV+ + T +E C ++ W+++G +L + +
Sbjct: 3390 PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG 3449
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A G+ + S + IQ P + I+ Q VG
Sbjct: 3450 --VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVE 3507
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ G P P+V W K G L + V+RI ++ + + +Y A+N A
Sbjct: 3508 FECLALGDPKPQVTWSKVGGHLRPG------IVQSGGVVRIAHVELADAGQYRCTATNAA 3561
Query: 1652 GTSSVEVTLKVYDKP 1666
GT+ V L V P
Sbjct: 3562 GTTQSHVLLLVQALP 3576
Score = 46.4 bits (105), Expect = 0.001
Identities = 27/78 (34%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV F C G P P I W I PS + TL+IR+V D G +TC
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTC 479
Query: 584 VAKNAAGFASSTTELIVE 601
A NA G + ++E
Sbjct: 480 EAMNARGMVFGIPDGVLE 497
Score = 44.8 bits (101), Expect = 0.003
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 3/83 (3%)
Query: 734 PPQVIEPLKSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKALP--TKSDGDTHSIT 790
PPQV+ P + I +G++V + +G P P I W N + + P T +
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
Query: 791 ILKPKKVKDEGVYTLKAENSEGI 813
I++ K D+G YT +A N+ G+
Sbjct: 465 IIRDVKESDQGAYTCEAMNARGM 487
Score = 42.3 bits (95), Expect = 0.018
Identities = 28/108 (25%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 1550 CIAFNDHGEVETSCV-----VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV 1604
CI + H + E+ C G V+T E I+ G T V G+P P +
Sbjct: 381 CIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR--GQTVTFTCVAIGVPTPII 438
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
W N + + +T++ + I+++K S YT EA N G
Sbjct: 439 NWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 36.7 bits (81), Expect = 0.91
Identities = 66/347 (19%), Positives = 118/347 (34%), Gaps = 13/347 (3%)
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINIC 1400
+ + L V+ +DAG+Y N + + + PS P + E S S+
Sbjct: 1727 QGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPG 1786
Query: 1401 WDEPEN-TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
D T S Y + + + + + +I+N++ + + + N
Sbjct: 1787 ADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMF 1846
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
+ + T V + +P V +T +P + E C G P P + W
Sbjct: 1847 AMDQGTATLH---VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP 1903
Query: 1520 KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ--QKPVITISN 1577
AKA Y C A + G+ V+ + P + +S
Sbjct: 1904 GGQLPAKAQIHG-GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP 1962
Query: 1578 EDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKR 1637
E Q H G + G+P + W K G L + + + + I +
Sbjct: 1963 ER-TQVH-AGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITT 2017
Query: 1638 SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + Y A++ AGT+ + + V S P + E S SVT
Sbjct: 2018 ADAGFYLCVATSPAGTAQARIQVVVL-SASDASPPPVKIESSSPSVT 2063
Score = 35.9 bits (79), Expect = 1.6
Identities = 19/82 (23%), Positives = 39/82 (47%), Gaps = 2/82 (2%)
Query: 1105 LPPEIITRLQNQ-KVNKGNKATFE-IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
+PP+++T + + ++G TF + + ++ W + I + +T +G +
Sbjct: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
Query: 1163 LKIYDCDLDDAGEYSCEVGNSK 1184
L I D D G Y+CE N++
Sbjct: 464 LIIRDVKESDQGAYTCEAMNAR 485
Score = 34.7 bits (76), Expect = 3.7
Identities = 22/87 (25%), Positives = 33/87 (37%), Gaps = 5/87 (5%)
Query: 632 IPPTFSKKPKAQY-VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
+PP P+ G + C + +P P I W I ++V E
Sbjct: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR-- 461
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG 717
L I +VK+ +G YT A+N G
Sbjct: 462 --GTLIIRDVKESDQGAYTCEAMNARG 486
>AL590103-2|CAI12125.1| 4391|Homo sapiens heparan sulfate proteoglycan
2 (perlecan) protein.
Length = 4391
Score = 113 bits (272), Expect = 7e-24
Identities = 178/814 (21%), Positives = 311/814 (38%), Gaps = 104/814 (12%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
PI++E H +G T+ C V G Q+TW+++ + P++ + + L
Sbjct: 2926 PIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL-PARH------QTHGSQLR 2977
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
+ V P D+G + C A + G V P S+ GS +
Sbjct: 2978 LHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSE-GSSYRLRS-------------- 3021
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDM 688
P S P + V +G D +C + P + W + +E+ ++N+ ++
Sbjct: 3022 ----PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNG-- 3073
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVR 747
S++ I + GTY VA N G A + L + PP V + P + V+
Sbjct: 3074 ----SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHG----PPTVSVLPEGPVWVK 3125
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG--DTHSITILKPKKVKDEGVYTL 805
G++V L G PR + W + + L ++ G D+H++ + K D G Y
Sbjct: 3126 VGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVC 3185
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A+N+ G A+ + V+ P + E+TV+ T L T +P P+I
Sbjct: 3186 LAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE-AELTVEAGHTATLRCSATGSPAPTIH 3244
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W +++ SP +G+ L+I V + DSG Y C A++ AG + A + + V
Sbjct: 3245 W---SKLRSPLPW-QHRLEGDT--LIIPRVAQQ-DSGQYICNATSPAGHAE--ATIILHV 3295
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXX 983
E + + + + G+TV L+C T ++ +W + G R
Sbjct: 3296 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR------ATARNEL 3349
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G +C V ++ S + + L + ++V E
Sbjct: 3350 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE 3409
Query: 1044 TADVVWERDGEIIKPKKNKYD---FEKRGHIRK--------LYIRNTSVHDEGEYSCILR 1092
T + + P F++ G + L I+N +G Y C
Sbjct: 3410 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3469
Query: 1093 DE----SCTAEVTVVELPPEIIT-RLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSE 1145
+A++ + LP +I R Q V G+ FE L GD V W K G
Sbjct: 3470 GPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC-LALGDPKPQVTWSKVGG- 3527
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT----AILTVEE-PSINFTL 1200
H++ I ++I +L DAG+Y C N+ T +L V+ P I+
Sbjct: 3528 -----HLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS--- 3579
Query: 1201 RLPEFILVPANTDA-YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
+P+ + VPA + A + + T D++W K + S ++ L++
Sbjct: 3580 -MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPD------SRLENNMLMLPSVR 3632
Query: 1260 EDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDY 1293
D Y C + + K ++ P ++V Y
Sbjct: 3633 PQDAGTYVCTATNRQGKVKAFAH-LQVPERVVPY 3665
Score = 99.1 bits (236), Expect = 2e-19
Identities = 260/1257 (20%), Positives = 443/1257 (35%), Gaps = 187/1257 (14%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV+ C+ G P ITW ++ + P Q + ++ATL+I + DAG + C
Sbjct: 1970 GRTVRLYCRAAGVPSATITWRKEGGSLPP----QARSERTDIATLLIPAITTADAGFYLC 2025
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA + AG A + + +V SD PP + +
Sbjct: 2026 VATSPAGTAQARIQ-VVVLSASDAS------------------------PPPVKIESSSP 2060
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG + L C + + W +G + P + + S L++ V
Sbjct: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----------HGSRLRLPQVSPA 2110
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-----------IEPLKSMIVRQGESV 752
G Y N G I + + G P IEP S V +G+++
Sbjct: 2111 DSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP-SSSHVAEGQTL 2169
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDEGVYTLKAENSE 811
L+ V G +TW K +LP + TH S+ L D G Y +
Sbjct: 2170 DLNCVVPGQAHAQVTWHKRG---GSLPARH--QTHGSLLRLHQVTPADSGEYVCHVVGTS 2224
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
G E S ++T+E PP+ I TV E T+ L V +TWY+
Sbjct: 2225 GPLEASVLVTIEASVIPGPIPPVRIES-SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGG 2283
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-------SHGARVTID 924
+ + G + + S D+G Y C ASN S + GA +
Sbjct: 2284 SLPARHQVR----GSRLYIFQA---SPADAGQYVCRASNGMEASITVTVTGTQGANLAYP 2336
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWYH--NKKEISGMDHREIIQEG 979
++ S + EG+T+ L C SH T W+ + H +++
Sbjct: 2337 AGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVT-WHKRGGSLPVRHQTHGSLLRLY 2395
Query: 980 RXXXXXXX----XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAI 1035
+ V + ++ E + + P + +V E
Sbjct: 2396 QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLD 2455
Query: 1036 LEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
L + + A V W + G + P +++ H +L + + D GEY C +
Sbjct: 2456 LNCLVAGQAHAQVTWHKRGGSL-PARHQV------HGSRLRLLQVTPADSGEYVCRVVGS 2508
Query: 1095 SCTAEVTVVELPPEIIT-----------RLQNQKVNKGNKATFEIE---LTKGDALVRWF 1140
S T E +V+ + ++ R+++ + N T ++ ++ + W+
Sbjct: 2509 SGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWY 2568
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVE---- 1192
K G + S H I G +L+I D+GEY C V G+ + + I+T++
Sbjct: 2569 KRGGSLP-SRH---QIVG--SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS 2622
Query: 1193 --EPSINFTLRLPEF--ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE-------K 1241
PS++ +R+ +V T V +TWYK+ + +
Sbjct: 2623 SHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLR 2682
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKR 1301
+S + R D E + V+ + S P +I
Sbjct: 2683 LHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGE 2742
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
D+ +V QA Q W + T+ S L + V D+G Y R
Sbjct: 2743 TLDLNCVVPGQAHAQVT--WHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCR 2794
Query: 1362 LENNCGHADVEMNVTI-------LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
+ + G + + VTI + P+P G P I I+ SS + G + +
Sbjct: 2795 VMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPI-RIEPSSSRVA------EGQTLDLK 2847
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQN--LKTN--SSYRFRAYAVNEVDISDASETTEY 1470
VV Q W + + L+ N S Y+ S E +
Sbjct: 2848 CVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
Query: 1471 YKVIKET--KIQSPTVEKPL----KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
+ + I +P + +P+ + + ++L C+ G +VTWY+ G L
Sbjct: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA 2967
Query: 1525 AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQ---------QKPVIT 1574
T+ ++ Y C A + G E E S V + + PVI+
Sbjct: 2968 RHQTHGSQ--LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVIS 3025
Query: 1575 IS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
I + ++Q + L+ +G P + W +LE+ N+ S+I I
Sbjct: 3026 IDPPSSTVQQGQDASFKCLIH---DGAAPISLEWKTRNQELED----NVHISPNGSIITI 3078
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS---KPEGPVIMREISRESVTIE 1686
+ S+ Y ASN G + V L V+ P+ PEGPV ++ ++VT+E
Sbjct: 3079 VGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVK--VGKAVTLE 3133
Score = 90.6 bits (215), Expect = 5e-17
Identities = 265/1244 (21%), Positives = 452/1244 (36%), Gaps = 190/1244 (15%)
Query: 505 EQSMAPIFVEKLRPKHT--PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
E + AP+ VE + P + P G + CQV G P W R+ PS Q +
Sbjct: 1671 ETNQAPLVVE-VHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS 1729
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDHGSEMTVXXXXXXXX 621
+ L V P DAG + C +N +S EL+V EAP +TV
Sbjct: 1730 E----LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAP----SKPITV-----TVE 1776
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G TF K++ + L+ RL P A F G I+ N+
Sbjct: 1777 EQRSQSVRPGADVTFICTAKSK---SPAYTLVWTRLHNGKLPTRAMDFNG--ILTIRNVQ 1831
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL 741
+ SD Y V +N+ +GT T + V G S P+V PPQ
Sbjct: 1832 L---SDAGTY--VCTGSNMFAMDQGTAT-LHVQASGTLSAPVV------SIHPPQ----- 1874
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDE 800
+ V+ G+ G+P PT+ W P LP K+ H I L + D+
Sbjct: 1875 --LTVQPGQLAEFRCSATGSPTPTLEW--TGGPGGQLPAKA--QIHGGILRLPAVEPTDQ 1928
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
Y +A +S G AV+ V P + ++ + V T++L R P
Sbjct: 1929 AQYLCRAHSSAGQQVARAVLHV----HGGGGPRVQVSP-ERTQVHAGRTVRLYCRAAGVP 1983
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ITW + + P + +I ++ + D+G Y CVA++ AG + AR
Sbjct: 1984 SATITWRKEGGSLPPQ----ARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQ--AR 2037
Query: 921 VTIDVEKVTF-----VKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHR 973
+ + V + VK S EG+T+ L C + + + WY + H
Sbjct: 2038 IQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLP--PHT 2095
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKCIVKD----QETS-TMLVVKET--------IPEFI 1020
++ D G C V++ +E S T+ V+ T +P
Sbjct: 2096 QV----HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGST 2151
Query: 1021 RKLQ----DFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
R ++ V E L + + A V W + G + P ++ + G + +L+
Sbjct: 2152 RPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-PARH----QTHGSLLRLH 2206
Query: 1076 IRNTSVHDEGEYSCILRDESCTAEVTV-VELPPEII------TRLQNQKVNKGNKATFEI 1128
+ D GEY C + S E +V V + +I R+++ T ++
Sbjct: 2207 --QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDL 2264
Query: 1129 ELT---KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKC 1185
+ A V W+K G + + + + +L I+ DAG+Y C N
Sbjct: 2265 SCVVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQASPADAGQYVCRASNGME 2318
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD------------VTWYKKK 1233
+I + L P P + + +TLD VTW+K+
Sbjct: 2319 ASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG 2378
Query: 1234 SVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP------ 1287
+ L + + + D EY C +L + + V V P
Sbjct: 2379 G------SLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPA 2432
Query: 1288 ----PKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
P + ++ G D+ LV QA Q W + +H
Sbjct: 2433 LGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVT--WHKRGGSL-PARH-----QVH 2484
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI---LEIDSSSIN 1398
+ L + +V D+G Y R+ + G + + VTI + S + + I+SSS +
Sbjct: 2485 GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSAS 2544
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWI-------SVKNITKTQTSIQNLKTNSSYRF 1451
+ G++ + +V Q T W S I ++ I + S +
Sbjct: 2545 LA------NGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEY 2598
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP----NEDIELTCIFGG 1507
+ N + + ET+ + P+V P++ ++ P + ++L C+
Sbjct: 2599 VCHVSNG---AGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAR 2655
Query: 1508 VPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
PQ +TWY+ G L + T+ + Y C A N+ +E S V+ +
Sbjct: 2656 QPQAIITWYKRGGSLPSRHQTHGSH--LRLHQMSVADSGEYVCRANNNIDALEASIVISV 2713
Query: 1568 QQ---KPVITISNEDIK----QKHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
P S+ I+ H E L + V+ G +V W+K G L + +
Sbjct: 2714 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQ- 2772
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLK 1661
+ S +R+ + + S +Y ++G +SV VT++
Sbjct: 2773 -----TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
Score = 87.8 bits (208), Expect = 4e-16
Identities = 205/1006 (20%), Positives = 354/1006 (35%), Gaps = 118/1006 (11%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ PT + + V EG + L C + + W +G ++ + +
Sbjct: 2434 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGG----------SLPARHQV 2483
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLK----SM 744
+ S L++ V G Y V G EAS+ + ++ + V P++ S
Sbjct: 2484 HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSA 2543
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD--GDTHSITILKPKKVKDEGV 802
+ G ++ L+ V TITW K +LP++ G I + P D G
Sbjct: 2544 SLANGHTLDLNCLVASQAPHTITWYKRG---GSLPSRHQIVGSRLRIPQVTP---ADSGE 2597
Query: 803 YTLKAENSEGIAETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRN 859
Y N G ETS ++T++ + PP+ I TV E T+ L V R
Sbjct: 2598 YVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES-SSPTVVEGQTLDLNCVVARQ 2656
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P ITWY+ + PS T G ++ L + S DSG+Y C A+N+
Sbjct: 2657 PQAIITWYKRGGSL-PSRHQTH---GSHLRL---HQMSVADSGEYVCRANNNIDALEASI 2709
Query: 920 RVTIDVE--------KVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWY------- 961
+++ ++ S EG+T+ L C +H T W+
Sbjct: 2710 VISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVT-WHKRGGSLP 2768
Query: 962 -HNKKEIS--GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPE 1018
H++ S + H G + V+ I ++ + P
Sbjct: 2769 SHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP 2828
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
+ V E L+ + + A V W + G + P +++ H L +
Sbjct: 2829 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL-PARHQV------HGPLLRLN 2881
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTV-VELPPE-------------IITRLQNQKVNKGNK 1123
S D GEYSC + S T E +V V + P I + V +G
Sbjct: 2882 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2941
Query: 1124 ATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ + A V W+K G + + H +L+++ D+GEY C +
Sbjct: 2942 LDLNCVVPGQAHAQVTWYKRGGSLP-ARH-----QTHGSQLRLHLVSPADSGEYVCRAAS 2995
Query: 1183 S---KCTAILTVEEP---SINFTLRLPEFILVPANT------DAYLTVEIPD--ETLDVT 1228
+ A TV P ++ LR P + P ++ DA I D + +
Sbjct: 2996 GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLE 3055
Query: 1229 WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
W + +ED + + + I + Y CV +A + V + V P
Sbjct: 3056 WKTRNQELEDNVHISPNGSI----ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
Query: 1288 PKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
P + V E +K G VTL P+ + W S K + + A L
Sbjct: 3112 PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQ 3171
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPEN 1406
I + +DAG Y +N G A ++ V + PG P + + + + + +
Sbjct: 3172 ISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV-QAEEAELTV------E 3224
Query: 1407 TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
G++ + T W +++ Q ++ T R + I +A+
Sbjct: 3225 AGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG-DTLIIPRVAQQDSGQY-ICNATS 3282
Query: 1467 TTEYYKVIKETKIQSPTVEKPL-KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
+ + ++SP + ++ + + E ++L C+ G P W R G L
Sbjct: 3283 PAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL-PG 3341
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+AT N Y+C N G E + +Q P
Sbjct: 3342 RATARNE-LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP 3386
Score = 79.8 bits (188), Expect = 1e-13
Identities = 237/1247 (19%), Positives = 431/1247 (34%), Gaps = 144/1247 (11%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
++ + S P+ +E P T +G T+ C V G Q+TW+R+ + P +
Sbjct: 2044 SASDASPPPVKIESSSPSVT-EGQTLDLNCVVAGSAHAQVTWYRRGGSLPP-------HT 2095
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
+ + L + +V P D+G + C +N +G ++ + V HG+
Sbjct: 2096 QVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVL-----HGTHSGPSYTP---- 2146
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G +P + +V EG + L C + + W +G
Sbjct: 2147 -------VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG--------- 2190
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIE 739
++ + + S+L++ V G Y V G EAS+ + ++ P V
Sbjct: 2191 -SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRI 2249
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
S V +G+++ LS V G +TW K +LP + + I + D
Sbjct: 2250 ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRG---GSLPARHQVRGSRLYIFQASPA-D 2305
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-----TVKEKGTIKLVA 854
G Y +A N E S +TV N P + I V E T+ L
Sbjct: 2306 AGQYVCRASNG---MEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNC 2362
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
V +TW++ S + G + L S DSG+Y C S+
Sbjct: 2363 VVPGQSHAQVTWHKR----GGSLPVRHQTHGSLLRLYQA---SPADSGEYVCRVLGSSVP 2415
Query: 915 SSHGARVTID-------VEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEI 967
VTI+ + V+ S + EG+T+ L C + + +K+
Sbjct: 2416 LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG- 2474
Query: 968 SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV----KDQETSTMLVVKETIPEFIRKL 1023
+ R + R D G C V QE S ++ +++ + +
Sbjct: 2475 GSLPARHQVHGSR---LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQG 2531
Query: 1024 QDFEVK-EKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHI--RKLYIRNTS 1080
+ V+ E A L + +V + I K R I +L I +
Sbjct: 2532 VAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVT 2591
Query: 1081 VHDEGEYSCILRDESCTAEVTVV------------ELPPEIITRLQNQKVNKGNKATFE- 1127
D GEY C + + + + E +++ + P I + V +G
Sbjct: 2592 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC 2651
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS---- 1183
+ + A++ W+K G + S H L+++ + D+GEY C N+
Sbjct: 2652 VVARQPQAIITWYKRGGSLP-SRH-----QTHGSHLRLHQMSVADSGEYVCRANNNIDAL 2705
Query: 1184 KCTAILTV-------EEPSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKS 1234
+ + +++V P + +R+ A + L +P + VTW+K+
Sbjct: 2706 EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGG 2765
Query: 1235 VI---EDTEKFTL----ISDVKKRTLIIRKCTEDDQCEYT-CVLLDAKSTTKLKVEVVEF 1286
+ T L +S + R E + V ++A ++ + V
Sbjct: 2766 SLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2825
Query: 1287 PPKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P I R+ G D+ +V QA Q W K+ +
Sbjct: 2826 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT--W------HKRGGNLPARHQVHGPL 2877
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTI-LDKPSP---PGKPNILEIDSSSINIC 1400
L + +V D+G Y ++ + G + + VTI P P PG + I++SS ++
Sbjct: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV- 2936
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI----SVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
G + + VV Q W S+ +T S L S Y
Sbjct: 2937 -----TEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVC 2991
Query: 1457 NEVDISDASETTEYYKVIKETK-----IQSPTVEKPLKNITTEPNEDIELTC-IFGGVPQ 1510
+ + + ++ ++SP + + T + +D C I G
Sbjct: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
+ W ++L+ N Y+C+A N +G ++ + +
Sbjct: 3052 ISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
Query: 1571 PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVI 1630
P +++ E KVG + V G P W + + ++ + +V+
Sbjct: 3112 PTVSVLPEG-PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVL 3170
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
+I K S + Y A N GT+ +V + V P P + E
Sbjct: 3171 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE 3217
Score = 77.4 bits (182), Expect = 5e-13
Identities = 158/752 (21%), Positives = 274/752 (36%), Gaps = 88/752 (11%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
+Y+ NN L+ + I P P++ SM PI +E H +G T+ C
Sbjct: 2693 EYVCRANNNIDALEASI--VISVSPSAGSPSAPGSSM-PIRIES-SSSHVAEGETLDLNC 2748
Query: 532 QVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGF 591
V G Q+TW ++ + PS + + L + V P D+G + C ++G
Sbjct: 2749 VVPGQAHAQVTWHKRGGSL-PS------HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2801
Query: 592 ASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDI 651
++ + +EA GS G PP +P + V EG +
Sbjct: 2802 LEASVLVTIEA----SGS------------SAVHVPAPGGAPP-IRIEPSSSRVAEGQTL 2844
Query: 652 LLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV 711
L+C + + W +G + P + ++ +L++ V G Y+
Sbjct: 2845 DLKCVVPGQAHAQVTWHKRGGNL-PARH---------QVHGPLLRLNQVSPADSGEYSCQ 2894
Query: 712 AVNREGEASLPIVLKIKTGEKEP---PQVIEPL----KSMIVRQGESVILSAQVVGNPRP 764
G +++ I+ P P + +P+ S V +G+++ L+ V G
Sbjct: 2895 VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHA 2954
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+TW K + A ++ G + ++ P D G Y +A + G E A TV
Sbjct: 2955 QVTWYKRGGSLPA-RHQTHGSQLRLHLVSP---ADSGEYVCRAASGPG-PEQEASFTVTV 3009
Query: 825 PTEENA----EPPLFINRFQEITVKEKGTIKLVARVTRNPVP-SITWYRNNEIISPSETI 879
P E + P+ TV++ + P S+ W N+ + + I
Sbjct: 3010 PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHI 3069
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS-Y 938
+ N G I +V T + G Y+CVASN+ G + + V + V V L +
Sbjct: 3070 SPN--GSIITIVGTRPSNH---GTYRCVASNAYGVAQ--SVVNLSVHGPPTVSVLPEGPV 3122
Query: 939 ETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
+ GK V LEC ++ S +W + ++ R D G
Sbjct: 3123 WVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGT 3182
Query: 997 IKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
C+ ++ + V E I + + + A L VE TA + G
Sbjct: 3183 YVCLAQNALGTAQKQV-EVIVDTGAMAPGAPQVQAEEAELTVEA-GHTATLRCSATGSPA 3240
Query: 1057 -----KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPE 1108
++ ++ R L I + D G+Y C + AE T+ VE PP
Sbjct: 3241 PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY 3300
Query: 1109 IITRLQNQKVNKGNKATFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T ++ V G + L G +W + GS + + + L
Sbjct: 3301 ATTVPEHASVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPG------RATARNELLHFE 3353
Query: 1167 DCDLDDAGEYSC----EVGNSKCTAILTVEEP 1194
+D+G Y C +VG+++ A L V+ P
Sbjct: 3354 RAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGP 3385
Score = 73.7 bits (173), Expect = 6e-12
Identities = 217/1116 (19%), Positives = 390/1116 (34%), Gaps = 139/1116 (12%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P P+ V G + L CR +P I W +G + P + +D+ +
Sbjct: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDI----A 2008
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPI-VLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I + G Y VA + G A I V+ + + PP V S V +G+++
Sbjct: 2009 TLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTL 2068
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKAENSE 811
L+ V G+ +TW + +LP + H + P+ D G Y + EN
Sbjct: 2069 DLNCVVAGSAHAQVTWYRRG---GSLPPHT--QVHGSRLRLPQVSPADSGEYVCRVENGS 2123
Query: 812 GIAETSAVITVEEPTEE--------NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
G E S ++V T + P+ I V E T+ L V
Sbjct: 2124 GPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP-SSSHVAEGQTLDLNCVVPGQAHAQ 2182
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+TW++ + P+ T L+ + + DSG+Y C ++G VTI
Sbjct: 2183 VTWHKRGGSL-PARHQTHG------SLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
Query: 924 DVE----KVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQ 977
+ + V+ S EG+T+ L C + + WY K + R ++
Sbjct: 2236 EASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY---KRGGSLPARHQVR 2292
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKD-QETSTMLVVKET----IPEFIRKLQDFEVKEKD 1032
R D G C + E S + V T + Q ++
Sbjct: 2293 GSR---LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSS 2349
Query: 1033 VAILE---VEIN-----SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ E +++N A V W + G + P ++ + G + +LY S D
Sbjct: 2350 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL-PVRH----QTHGSLLRLY--QASPADS 2402
Query: 1085 GEYSCILRDESCTAEVTVV-------ELPPEIIT---RLQNQKVNKGNKATFEIE-LTKG 1133
GEY C + S E +V+ +P +T R+++ T ++ L G
Sbjct: 2403 GEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG 2462
Query: 1134 D--ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTA 1187
A V W K G + + + +L++ D+GEY C V G + +
Sbjct: 2463 QAHAQVTWHKRGGSLPARHQVH------GSRLRLLQVTPADSGEYVCRVVGSSGTQEASV 2516
Query: 1188 ILTVEE-------PSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKSVIED 1238
++T+++ + + +R+ AN L + + +TWYK+ +
Sbjct: 2517 LVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS 2576
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV---EFPPKIVDYER 1295
+ V R L I + T D EY C + + + + + V +
Sbjct: 2577 RHQI-----VGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
Query: 1296 EYRIKRGSDVTL---LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
RI+ S + +D + I+ K+ + + L + ++
Sbjct: 2631 PIRIESSSPTVVEGQTLDLNCVVARQPQAIIT--WYKRGGSLPSRHQTHGSHLRLHQMSV 2688
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTI---LDKPSPPGKPNILEIDSSSINICWDEPENTGN 1409
D+G Y R NN + + +++ PS PG + I+SSS ++ E E
Sbjct: 2689 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA--EGETLDL 2746
Query: 1410 STIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ ++ Q S+ + +T+ S L S Y + S E +
Sbjct: 2747 NCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASV 2806
Query: 1470 YYKV----IKETKIQSPTVEKPLK----NITTEPNEDIELTCIFGGVPQPKVTWYRDGKK 1521
+ + +P P++ + + ++L C+ G +VTW++ G
Sbjct: 2807 LVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGN 2866
Query: 1522 LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK 1581
L + Y C G +E S +V I+ I +
Sbjct: 2867 LPARHQVH--GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLA 2924
Query: 1582 Q--------KHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
Q H + L + V+ G +V WYK G L + + S +R+
Sbjct: 2925 QPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH------GSQLRL 2978
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + S +Y A++ G E + V PS+
Sbjct: 2979 HLVSPADSGEYVCRAASGPGPEQ-EASFTVTVPPSE 3013
Score = 73.3 bits (172), Expect = 9e-12
Identities = 89/415 (21%), Positives = 159/415 (38%), Gaps = 54/415 (13%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TVQ +C G P W R + + + L PED+G + C
Sbjct: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARN-------ELLHFERAAPEDSGRYRC 3365
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
N G A + +L+V+ P GS I G PT P+ +
Sbjct: 3366 RVTNKVGSAEAFAQLLVQGP---PGS-------------LPATSIPAGSTPTVQVTPQLE 3409
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
G+ + C + + + W +G ++ P ++ VL+I N+ +
Sbjct: 3410 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG----------VLRIQNLDQS 3459
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
+GTY A G+A L I+ + +++++V G +V +G+P+
Sbjct: 3460 CQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV--GHAVEFECLALGDPK 3517
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P +TW K ++ +S G + + ++ D G Y A N+ G ++ ++ V+
Sbjct: 3518 PQVTWSKVGGHLRPGIVQSGG----VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ 3573
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
A P I+ QE+ V + P P I+W + + + P +
Sbjct: 3574 ------ALPQ--ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL---- 3621
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
EN L++ +V + D+G Y C A+N GK A + + V + S+
Sbjct: 3622 --ENNMLMLPSVRPQ-DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSF 3673
Score = 72.9 bits (171), Expect = 1e-11
Identities = 246/1313 (18%), Positives = 454/1313 (34%), Gaps = 176/1313 (13%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G T+ C V G Q+TW+++ + + + L I + P DAG +
Sbjct: 2258 EGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRG-------SRLYIFQASPADAGQYV 2310
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
C A N G +S T + G+ + G +P +
Sbjct: 2311 CRASN--GMEASITVTVT----GTQGANLAYPA---------------GSTQPIRIEPSS 2349
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKK 702
V EG + L C + + W +G S+ + H S+L++
Sbjct: 2350 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGG--------SLPVRHQTHG--SLLRLYQASP 2399
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL-----KSMIVRQGESVILSAQ 757
G Y + +++ I+ P + P S V +G+++ L+
Sbjct: 2400 ADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCL 2459
Query: 758 VVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETS 817
V G +TW K +LP + + +L+ D G Y + S G E S
Sbjct: 2460 VAGQAHAQVTWHKRGG---SLPARHQVHGSRLRLLQVTPA-DSGEYVCRVVGSSGTQEAS 2515
Query: 818 AVITVEEPTE-ENAEPPLFINRFQE--ITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
++T+++ +++ + R + ++ T+ L V +ITWY+ +
Sbjct: 2516 VLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP 2575
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID------VEKV 928
I + L I V + DSG+Y C SN AG VTI V V
Sbjct: 2576 SRHQIVGS------RLRIPQV-TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSV 2628
Query: 929 TFVKHLQKSYETE-EGKTVILECQTSHTVST--KWYHNKKEISGM-----DHREIIQEGR 980
+ ++ S T EG+T+ L C + WY + H + Q
Sbjct: 2629 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSV 2688
Query: 981 XXXXXXXXXXXXDVGVIKC---IVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILE 1037
++ ++ I + ++P I + + + +
Sbjct: 2689 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNC 2748
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
V A V W + G + P + + RG +L + + S D GEY C + S
Sbjct: 2749 VVPGQAHAQVTWHKRGGSL-PSHH----QTRGS--RLRLHHVSPADSGEYVCRVMGSSGP 2801
Query: 1098 AEVTV-----------VELP-----PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWF 1140
E +V V +P P I + +V +G + + + A V W
Sbjct: 2802 LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWH 2861
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT---AILTVEEPSIN 1197
K G + + + + L++ D+GEYSC+V S T ++L EPS
Sbjct: 2862 KRGGNLPARHQVHGPL------LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2915
Query: 1198 FTLRLPEF---ILVPANTDAY-------LTVEIPDET-LDVTWYKKKSVIEDTE------ 1240
+ P I + A++ L +P + VTWYK+ +
Sbjct: 2916 GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ 2975
Query: 1241 -KFTLISDVKKRTLIIRKCT---EDDQCEYTCVLLDAK-STTKLKVEVVEFPPKIVDYER 1295
+ L+S + R + + + +T + ++ S+ +L+ V+ P
Sbjct: 2976 LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPP------ 3029
Query: 1296 EYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT 1353
+++G D + L+ A P + EW ++ ++ H P+ + +TI +
Sbjct: 3030 SSTVQQGQDASFKCLIHDGAAPI-SLEWKTRNQELEDNVHISPN----GSIITIVGTRPS 3084
Query: 1354 DAGIYKLRLENNCGHADVEMNVTILDKPSP---PGKPNILEIDSSSINICWD--EPENTG 1408
+ G Y+ N G A +N+++ P+ P P +++ + C EP ++
Sbjct: 3085 NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSA 3144
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETT 1468
T I E T + + + I + K + + + A N + A +
Sbjct: 3145 RWTRISSTPAKLEQRTYGLMDSHAVLQ----ISSAKPSDAGTYVCLAQNA--LGTAQKQV 3198
Query: 1469 EYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT 1528
E +P V+ +T E L C G P P + W KL+ +
Sbjct: 3199 EVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHW----SKLR-SPLP 3253
Query: 1529 YENRXXXXXX---XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHK 1585
+++R Y C A + G E + ++ ++ P T E +
Sbjct: 3254 WQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASV--Q 3311
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
G+ + + G PP W + G+ L + ++ + S +Y
Sbjct: 3312 AGETVQLQCLAHGTPPLTFQWSRVGSSLPG------RATARNELLHFERAAPEDSGRYRC 3365
Query: 1646 EASNTAGTSSVEVTLKVYDKP-SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+N G++ L V P S P + VT + + +E A+
Sbjct: 3366 RVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEF-HCAVP 3424
Query: 1705 KHEPDNNRWIKVA---DVDRDVE--TYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
RW K V+ IQ L+++C+ + A P G ++A
Sbjct: 3425 SDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQA 3477
Score = 53.2 bits (122), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 49/435 (11%)
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV-------EFPPKIVDYEREYRIKRGSDV 1305
L I D Y C+ +A T + +VEV+ P++ E E ++ G
Sbjct: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTA 3229
Query: 1306 TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SIDSKSASLTIKKVENTDAGIYKLRLEN 1364
TL P P W K + P + +L I +V D+G Y +
Sbjct: 3230 TLRCSATGSPAPTIHW-------SKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATS 3282
Query: 1365 NCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
GHA+ + IL SPP + E +S+ G + + + T
Sbjct: 3283 PAGHAEATI---ILHVESPPYATTVPE--HASVQ--------AGETVQLQCLAHGTPPLT 3329
Query: 1425 TEWISVKNITKTQTSIQN-------LKTNSSYRFRAYAVNEVDISDASETTEYYKV---I 1474
+W V + + + +N S R+R N+V ++A +
Sbjct: 3330 FQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL 3389
Query: 1475 KETKI---QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
T I +PTV+ + T +E C ++ W+++G +L + +
Sbjct: 3390 PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG 3449
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A G+ + S + IQ P + I+ Q VG
Sbjct: 3450 --VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVE 3507
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ G P P+V W K G L + V+RI ++ + + +Y A+N A
Sbjct: 3508 FECLALGDPKPQVTWSKVGGHLRPG------IVQSGGVVRIAHVELADAGQYRCTATNAA 3561
Query: 1652 GTSSVEVTLKVYDKP 1666
GT+ V L V P
Sbjct: 3562 GTTQSHVLLLVQALP 3576
Score = 46.4 bits (105), Expect = 0.001
Identities = 27/78 (34%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV F C G P P I W I PS + TL+IR+V D G +TC
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTC 479
Query: 584 VAKNAAGFASSTTELIVE 601
A NA G + ++E
Sbjct: 480 EAMNARGMVFGIPDGVLE 497
Score = 44.8 bits (101), Expect = 0.003
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 3/83 (3%)
Query: 734 PPQVIEPLKSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKALP--TKSDGDTHSIT 790
PPQV+ P + I +G++V + +G P P I W N + + P T +
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
Query: 791 ILKPKKVKDEGVYTLKAENSEGI 813
I++ K D+G YT +A N+ G+
Sbjct: 465 IIRDVKESDQGAYTCEAMNARGM 487
Score = 42.3 bits (95), Expect = 0.018
Identities = 28/108 (25%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 1550 CIAFNDHGEVETSCV-----VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV 1604
CI + H + E+ C G V+T E I+ G T V G+P P +
Sbjct: 381 CIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR--GQTVTFTCVAIGVPTPII 438
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
W N + + +T++ + I+++K S YT EA N G
Sbjct: 439 NWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 36.7 bits (81), Expect = 0.91
Identities = 66/347 (19%), Positives = 118/347 (34%), Gaps = 13/347 (3%)
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINIC 1400
+ + L V+ +DAG+Y N + + + PS P + E S S+
Sbjct: 1727 QGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPG 1786
Query: 1401 WDEPEN-TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
D T S Y + + + + + +I+N++ + + + N
Sbjct: 1787 ADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMF 1846
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
+ + T V + +P V +T +P + E C G P P + W
Sbjct: 1847 AMDQGTATLH---VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP 1903
Query: 1520 KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ--QKPVITISN 1577
AKA Y C A + G+ V+ + P + +S
Sbjct: 1904 GGQLPAKAQIHG-GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP 1962
Query: 1578 EDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKR 1637
E Q H G + G+P + W K G L + + + + I +
Sbjct: 1963 ER-TQVH-AGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITT 2017
Query: 1638 SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + Y A++ AGT+ + + V S P + E S SVT
Sbjct: 2018 ADAGFYLCVATSPAGTAQARIQVVVL-SASDASPPPVKIESSSPSVT 2063
Score = 35.9 bits (79), Expect = 1.6
Identities = 19/82 (23%), Positives = 39/82 (47%), Gaps = 2/82 (2%)
Query: 1105 LPPEIITRLQNQ-KVNKGNKATFE-IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
+PP+++T + + ++G TF + + ++ W + I + +T +G +
Sbjct: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
Query: 1163 LKIYDCDLDDAGEYSCEVGNSK 1184
L I D D G Y+CE N++
Sbjct: 464 LIIRDVKESDQGAYTCEAMNAR 485
Score = 34.7 bits (76), Expect = 3.7
Identities = 22/87 (25%), Positives = 33/87 (37%), Gaps = 5/87 (5%)
Query: 632 IPPTFSKKPKAQY-VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
+PP P+ G + C + +P P I W I ++V E
Sbjct: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR-- 461
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG 717
L I +VK+ +G YT A+N G
Sbjct: 462 --GTLIIRDVKESDQGAYTCEAMNARG 486
>AL445795-1|CAC18534.1| 4370|Homo sapiens heparan sulfate proteoglycan
perlecan protein.
Length = 4370
Score = 113 bits (272), Expect = 7e-24
Identities = 178/814 (21%), Positives = 311/814 (38%), Gaps = 104/814 (12%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
PI++E H +G T+ C V G Q+TW+++ + P++ + + L
Sbjct: 2905 PIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL-PARH------QTHGSQLR 2956
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
+ V P D+G + C A + G V P S+ GS +
Sbjct: 2957 LHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSE-GSSYRLRS-------------- 3000
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDM 688
P S P + V +G D +C + P + W + +E+ ++N+ ++
Sbjct: 3001 ----PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNG-- 3052
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVR 747
S++ I + GTY VA N G A + L + PP V + P + V+
Sbjct: 3053 ----SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHG----PPTVSVLPEGPVWVK 3104
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG--DTHSITILKPKKVKDEGVYTL 805
G++V L G PR + W + + L ++ G D+H++ + K D G Y
Sbjct: 3105 VGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVC 3164
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A+N+ G A+ + V+ P + E+TV+ T L T +P P+I
Sbjct: 3165 LAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE-AELTVEAGHTATLRCSATGSPAPTIH 3223
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W +++ SP +G+ L+I V + DSG Y C A++ AG + A + + V
Sbjct: 3224 W---SKLRSPLPW-QHRLEGDT--LIIPRVAQQ-DSGQYICNATSPAGHAE--ATIILHV 3274
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXX 983
E + + + + G+TV L+C T ++ +W + G R
Sbjct: 3275 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR------ATARNEL 3328
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G +C V ++ S + + L + ++V E
Sbjct: 3329 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE 3388
Query: 1044 TADVVWERDGEIIKPKKNKYD---FEKRGHIRK--------LYIRNTSVHDEGEYSCILR 1092
T + + P F++ G + L I+N +G Y C
Sbjct: 3389 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3448
Query: 1093 DE----SCTAEVTVVELPPEIIT-RLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSE 1145
+A++ + LP +I R Q V G+ FE L GD V W K G
Sbjct: 3449 GPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC-LALGDPKPQVTWSKVGG- 3506
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT----AILTVEE-PSINFTL 1200
H++ I ++I +L DAG+Y C N+ T +L V+ P I+
Sbjct: 3507 -----HLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS--- 3558
Query: 1201 RLPEFILVPANTDA-YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
+P+ + VPA + A + + T D++W K + S ++ L++
Sbjct: 3559 -MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPD------SRLENNMLMLPSVR 3611
Query: 1260 EDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDY 1293
D Y C + + K ++ P ++V Y
Sbjct: 3612 PQDAGTYVCTATNRQGKVKAFAH-LQVPERVVPY 3644
Score = 99.1 bits (236), Expect = 2e-19
Identities = 260/1257 (20%), Positives = 443/1257 (35%), Gaps = 187/1257 (14%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV+ C+ G P ITW ++ + P Q + ++ATL+I + DAG + C
Sbjct: 1949 GRTVRLYCRAAGVPSATITWRKEGGSLPP----QARSERTDIATLLIPAITTADAGFYLC 2004
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA + AG A + + +V SD PP + +
Sbjct: 2005 VATSPAGTAQARIQ-VVVLSASDAS------------------------PPPVKIESSSP 2039
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
V EG + L C + + W +G + P + + S L++ V
Sbjct: 2040 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----------HGSRLRLPQVSPA 2089
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-----------IEPLKSMIVRQGESV 752
G Y N G I + + G P IEP S V +G+++
Sbjct: 2090 DSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP-SSSHVAEGQTL 2148
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDEGVYTLKAENSE 811
L+ V G +TW K +LP + TH S+ L D G Y +
Sbjct: 2149 DLNCVVPGQAHAQVTWHKRG---GSLPARH--QTHGSLLRLHQVTPADSGEYVCHVVGTS 2203
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
G E S ++T+E PP+ I TV E T+ L V +TWY+
Sbjct: 2204 GPLEASVLVTIEASVIPGPIPPVRIES-SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGG 2262
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-------SHGARVTID 924
+ + G + + S D+G Y C ASN S + GA +
Sbjct: 2263 SLPARHQVR----GSRLYIFQA---SPADAGQYVCRASNGMEASITVTVTGTQGANLAYP 2315
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWYH--NKKEISGMDHREIIQEG 979
++ S + EG+T+ L C SH T W+ + H +++
Sbjct: 2316 AGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVT-WHKRGGSLPVRHQTHGSLLRLY 2374
Query: 980 RXXXXXXX----XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAI 1035
+ V + ++ E + + P + +V E
Sbjct: 2375 QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLD 2434
Query: 1036 LEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
L + + A V W + G + P +++ H +L + + D GEY C +
Sbjct: 2435 LNCLVAGQAHAQVTWHKRGGSL-PARHQV------HGSRLRLLQVTPADSGEYVCRVVGS 2487
Query: 1095 SCTAEVTVVELPPEIIT-----------RLQNQKVNKGNKATFEIE---LTKGDALVRWF 1140
S T E +V+ + ++ R+++ + N T ++ ++ + W+
Sbjct: 2488 SGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWY 2547
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVE---- 1192
K G + S H I G +L+I D+GEY C V G+ + + I+T++
Sbjct: 2548 KRGGSLP-SRH---QIVG--SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS 2601
Query: 1193 --EPSINFTLRLPEF--ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE-------K 1241
PS++ +R+ +V T V +TWYK+ + +
Sbjct: 2602 SHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLR 2661
Query: 1242 FTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKR 1301
+S + R D E + V+ + S P +I
Sbjct: 2662 LHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGE 2721
Query: 1302 GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLR 1361
D+ +V QA Q W + T+ S L + V D+G Y R
Sbjct: 2722 TLDLNCVVPGQAHAQVT--WHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCR 2773
Query: 1362 LENNCGHADVEMNVTI-------LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
+ + G + + VTI + P+P G P I I+ SS + G + +
Sbjct: 2774 VMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPI-RIEPSSSRVA------EGQTLDLK 2826
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQN--LKTN--SSYRFRAYAVNEVDISDASETTEY 1470
VV Q W + + L+ N S Y+ S E +
Sbjct: 2827 CVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVL 2886
Query: 1471 YKVIKET--KIQSPTVEKPL----KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
+ + I +P + +P+ + + ++L C+ G +VTWY+ G L
Sbjct: 2887 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA 2946
Query: 1525 AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQ---------QKPVIT 1574
T+ ++ Y C A + G E E S V + + PVI+
Sbjct: 2947 RHQTHGSQ--LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVIS 3004
Query: 1575 IS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
I + ++Q + L+ +G P + W +LE+ N+ S+I I
Sbjct: 3005 IDPPSSTVQQGQDASFKCLIH---DGAAPISLEWKTRNQELED----NVHISPNGSIITI 3057
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS---KPEGPVIMREISRESVTIE 1686
+ S+ Y ASN G + V L V+ P+ PEGPV ++ ++VT+E
Sbjct: 3058 VGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVK--VGKAVTLE 3112
Score = 90.6 bits (215), Expect = 5e-17
Identities = 265/1244 (21%), Positives = 452/1244 (36%), Gaps = 190/1244 (15%)
Query: 505 EQSMAPIFVEKLRPKHT--PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
E + AP+ VE + P + P G + CQV G P W R+ PS Q +
Sbjct: 1650 ETNQAPLVVE-VHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS 1708
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDHGSEMTVXXXXXXXX 621
+ L V P DAG + C +N +S EL+V EAP +TV
Sbjct: 1709 E----LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAP----SKPITV-----TVE 1755
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G TF K++ + L+ RL P A F G I+ N+
Sbjct: 1756 EQRSQSVRPGADVTFICTAKSK---SPAYTLVWTRLHNGKLPTRAMDFNG--ILTIRNVQ 1810
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL 741
+ SD Y V +N+ +GT T + V G S P+V PPQ
Sbjct: 1811 L---SDAGTY--VCTGSNMFAMDQGTAT-LHVQASGTLSAPVV------SIHPPQ----- 1853
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDE 800
+ V+ G+ G+P PT+ W P LP K+ H I L + D+
Sbjct: 1854 --LTVQPGQLAEFRCSATGSPTPTLEW--TGGPGGQLPAKA--QIHGGILRLPAVEPTDQ 1907
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
Y +A +S G AV+ V P + ++ + V T++L R P
Sbjct: 1908 AQYLCRAHSSAGQQVARAVLHV----HGGGGPRVQVSP-ERTQVHAGRTVRLYCRAAGVP 1962
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ITW + + P + +I ++ + D+G Y CVA++ AG + AR
Sbjct: 1963 SATITWRKEGGSLPPQ----ARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQ--AR 2016
Query: 921 VTIDVEKVTF-----VKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHR 973
+ + V + VK S EG+T+ L C + + + WY + H
Sbjct: 2017 IQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLP--PHT 2074
Query: 974 EIIQEGRXXXXXXXXXXXXDVGVIKCIVKD----QETS-TMLVVKET--------IPEFI 1020
++ D G C V++ +E S T+ V+ T +P
Sbjct: 2075 QV----HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGST 2130
Query: 1021 RKLQ----DFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
R ++ V E L + + A V W + G + P ++ + G + +L+
Sbjct: 2131 RPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-PARH----QTHGSLLRLH 2185
Query: 1076 IRNTSVHDEGEYSCILRDESCTAEVTV-VELPPEII------TRLQNQKVNKGNKATFEI 1128
+ D GEY C + S E +V V + +I R+++ T ++
Sbjct: 2186 --QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDL 2243
Query: 1129 ELT---KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKC 1185
+ A V W+K G + + + + +L I+ DAG+Y C N
Sbjct: 2244 SCVVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQASPADAGQYVCRASNGME 2297
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD------------VTWYKKK 1233
+I + L P P + + +TLD VTW+K+
Sbjct: 2298 ASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG 2357
Query: 1234 SVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP------ 1287
+ L + + + D EY C +L + + V V P
Sbjct: 2358 G------SLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPA 2411
Query: 1288 ----PKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
P + ++ G D+ LV QA Q W + +H
Sbjct: 2412 LGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVT--WHKRGGSL-PARH-----QVH 2463
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI---LEIDSSSIN 1398
+ L + +V D+G Y R+ + G + + VTI + S + + I+SSS +
Sbjct: 2464 GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSAS 2523
Query: 1399 ICWDEPENTGNSTIIYYVVEYQEIDTTEWI-------SVKNITKTQTSIQNLKTNSSYRF 1451
+ G++ + +V Q T W S I ++ I + S +
Sbjct: 2524 LA------NGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEY 2577
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP----NEDIELTCIFGG 1507
+ N + + ET+ + P+V P++ ++ P + ++L C+
Sbjct: 2578 VCHVSNG---AGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAR 2634
Query: 1508 VPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI 1567
PQ +TWY+ G L + T+ + Y C A N+ +E S V+ +
Sbjct: 2635 QPQAIITWYKRGGSLPSRHQTHGSH--LRLHQMSVADSGEYVCRANNNIDALEASIVISV 2692
Query: 1568 QQ---KPVITISNEDIK----QKHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
P S+ I+ H E L + V+ G +V W+K G L + +
Sbjct: 2693 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQ- 2751
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLK 1661
+ S +R+ + + S +Y ++G +SV VT++
Sbjct: 2752 -----TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2790
Score = 87.8 bits (208), Expect = 4e-16
Identities = 205/1006 (20%), Positives = 354/1006 (35%), Gaps = 118/1006 (11%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ PT + + V EG + L C + + W +G ++ + +
Sbjct: 2413 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGG----------SLPARHQV 2462
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLK----SM 744
+ S L++ V G Y V G EAS+ + ++ + V P++ S
Sbjct: 2463 HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSA 2522
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD--GDTHSITILKPKKVKDEGV 802
+ G ++ L+ V TITW K +LP++ G I + P D G
Sbjct: 2523 SLANGHTLDLNCLVASQAPHTITWYKRG---GSLPSRHQIVGSRLRIPQVTP---ADSGE 2576
Query: 803 YTLKAENSEGIAETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRN 859
Y N G ETS ++T++ + PP+ I TV E T+ L V R
Sbjct: 2577 YVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES-SSPTVVEGQTLDLNCVVARQ 2635
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P ITWY+ + PS T G ++ L + S DSG+Y C A+N+
Sbjct: 2636 PQAIITWYKRGGSL-PSRHQTH---GSHLRL---HQMSVADSGEYVCRANNNIDALEASI 2688
Query: 920 RVTIDVE--------KVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWY------- 961
+++ ++ S EG+T+ L C +H T W+
Sbjct: 2689 VISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVT-WHKRGGSLP 2747
Query: 962 -HNKKEIS--GMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPE 1018
H++ S + H G + V+ I ++ + P
Sbjct: 2748 SHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP 2807
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
+ V E L+ + + A V W + G + P +++ H L +
Sbjct: 2808 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL-PARHQV------HGPLLRLN 2860
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTV-VELPPE-------------IITRLQNQKVNKGNK 1123
S D GEYSC + S T E +V V + P I + V +G
Sbjct: 2861 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2920
Query: 1124 ATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ + A V W+K G + + H +L+++ D+GEY C +
Sbjct: 2921 LDLNCVVPGQAHAQVTWYKRGGSLP-ARH-----QTHGSQLRLHLVSPADSGEYVCRAAS 2974
Query: 1183 S---KCTAILTVEEP---SINFTLRLPEFILVPANT------DAYLTVEIPD--ETLDVT 1228
+ A TV P ++ LR P + P ++ DA I D + +
Sbjct: 2975 GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLE 3034
Query: 1229 WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
W + +ED + + + I + Y CV +A + V + V P
Sbjct: 3035 WKTRNQELEDNVHISPNGSI----ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3090
Query: 1288 PKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
P + V E +K G VTL P+ + W S K + + A L
Sbjct: 3091 PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQ 3150
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPEN 1406
I + +DAG Y +N G A ++ V + PG P + + + + + +
Sbjct: 3151 ISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV-QAEEAELTV------E 3203
Query: 1407 TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
G++ + T W +++ Q ++ T R + I +A+
Sbjct: 3204 AGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG-DTLIIPRVAQQDSGQY-ICNATS 3261
Query: 1467 TTEYYKVIKETKIQSPTVEKPL-KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
+ + ++SP + ++ + + E ++L C+ G P W R G L
Sbjct: 3262 PAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL-PG 3320
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+AT N Y+C N G E + +Q P
Sbjct: 3321 RATARNE-LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP 3365
Score = 79.8 bits (188), Expect = 1e-13
Identities = 237/1247 (19%), Positives = 431/1247 (34%), Gaps = 144/1247 (11%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
++ + S P+ +E P T +G T+ C V G Q+TW+R+ + P +
Sbjct: 2023 SASDASPPPVKIESSSPSVT-EGQTLDLNCVVAGSAHAQVTWYRRGGSLPP-------HT 2074
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
+ + L + +V P D+G + C +N +G ++ + V HG+
Sbjct: 2075 QVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVL-----HGTHSGPSYTP---- 2125
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G +P + +V EG + L C + + W +G
Sbjct: 2126 -------VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG--------- 2169
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIE 739
++ + + S+L++ V G Y V G EAS+ + ++ P V
Sbjct: 2170 -SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRI 2228
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
S V +G+++ LS V G +TW K +LP + + I + D
Sbjct: 2229 ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRG---GSLPARHQVRGSRLYIFQASPA-D 2284
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-----TVKEKGTIKLVA 854
G Y +A N E S +TV N P + I V E T+ L
Sbjct: 2285 AGQYVCRASNG---MEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNC 2341
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
V +TW++ S + G + L S DSG+Y C S+
Sbjct: 2342 VVPGQSHAQVTWHKR----GGSLPVRHQTHGSLLRLYQA---SPADSGEYVCRVLGSSVP 2394
Query: 915 SSHGARVTID-------VEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEI 967
VTI+ + V+ S + EG+T+ L C + + +K+
Sbjct: 2395 LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG- 2453
Query: 968 SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV----KDQETSTMLVVKETIPEFIRKL 1023
+ R + R D G C V QE S ++ +++ + +
Sbjct: 2454 GSLPARHQVHGSR---LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQG 2510
Query: 1024 QDFEVK-EKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHI--RKLYIRNTS 1080
+ V+ E A L + +V + I K R I +L I +
Sbjct: 2511 VAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVT 2570
Query: 1081 VHDEGEYSCILRDESCTAEVTVV------------ELPPEIITRLQNQKVNKGNKATFE- 1127
D GEY C + + + + E +++ + P I + V +G
Sbjct: 2571 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC 2630
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS---- 1183
+ + A++ W+K G + S H L+++ + D+GEY C N+
Sbjct: 2631 VVARQPQAIITWYKRGGSLP-SRH-----QTHGSHLRLHQMSVADSGEYVCRANNNIDAL 2684
Query: 1184 KCTAILTV-------EEPSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKS 1234
+ + +++V P + +R+ A + L +P + VTW+K+
Sbjct: 2685 EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGG 2744
Query: 1235 VI---EDTEKFTL----ISDVKKRTLIIRKCTEDDQCEYT-CVLLDAKSTTKLKVEVVEF 1286
+ T L +S + R E + V ++A ++ + V
Sbjct: 2745 SLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2804
Query: 1287 PPKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P I R+ G D+ +V QA Q W K+ +
Sbjct: 2805 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT--W------HKRGGNLPARHQVHGPL 2856
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTI-LDKPSP---PGKPNILEIDSSSINIC 1400
L + +V D+G Y ++ + G + + VTI P P PG + I++SS ++
Sbjct: 2857 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV- 2915
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI----SVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
G + + VV Q W S+ +T S L S Y
Sbjct: 2916 -----TEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVC 2970
Query: 1457 NEVDISDASETTEYYKVIKETK-----IQSPTVEKPLKNITTEPNEDIELTC-IFGGVPQ 1510
+ + + ++ ++SP + + T + +D C I G
Sbjct: 2971 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3030
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
+ W ++L+ N Y+C+A N +G ++ + +
Sbjct: 3031 ISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3090
Query: 1571 PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVI 1630
P +++ E KVG + V G P W + + ++ + +V+
Sbjct: 3091 PTVSVLPEG-PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVL 3149
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
+I K S + Y A N GT+ +V + V P P + E
Sbjct: 3150 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE 3196
Score = 77.4 bits (182), Expect = 5e-13
Identities = 158/752 (21%), Positives = 274/752 (36%), Gaps = 88/752 (11%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
+Y+ NN L+ + I P P++ SM PI +E H +G T+ C
Sbjct: 2672 EYVCRANNNIDALEASI--VISVSPSAGSPSAPGSSM-PIRIES-SSSHVAEGETLDLNC 2727
Query: 532 QVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGF 591
V G Q+TW ++ + PS + + L + V P D+G + C ++G
Sbjct: 2728 VVPGQAHAQVTWHKRGGSL-PS------HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2780
Query: 592 ASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDI 651
++ + +EA GS G PP +P + V EG +
Sbjct: 2781 LEASVLVTIEA----SGS------------SAVHVPAPGGAPP-IRIEPSSSRVAEGQTL 2823
Query: 652 LLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV 711
L+C + + W +G + P + ++ +L++ V G Y+
Sbjct: 2824 DLKCVVPGQAHAQVTWHKRGGNL-PARH---------QVHGPLLRLNQVSPADSGEYSCQ 2873
Query: 712 AVNREGEASLPIVLKIKTGEKEP---PQVIEPL----KSMIVRQGESVILSAQVVGNPRP 764
G +++ I+ P P + +P+ S V +G+++ L+ V G
Sbjct: 2874 VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHA 2933
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE 824
+TW K + A ++ G + ++ P D G Y +A + G E A TV
Sbjct: 2934 QVTWYKRGGSLPA-RHQTHGSQLRLHLVSP---ADSGEYVCRAASGPG-PEQEASFTVTV 2988
Query: 825 PTEENA----EPPLFINRFQEITVKEKGTIKLVARVTRNPVP-SITWYRNNEIISPSETI 879
P E + P+ TV++ + P S+ W N+ + + I
Sbjct: 2989 PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHI 3048
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS-Y 938
+ N G I +V T + G Y+CVASN+ G + + V + V V L +
Sbjct: 3049 SPN--GSIITIVGTRPSNH---GTYRCVASNAYGVAQ--SVVNLSVHGPPTVSVLPEGPV 3101
Query: 939 ETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
+ GK V LEC ++ S +W + ++ R D G
Sbjct: 3102 WVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGT 3161
Query: 997 IKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEII 1056
C+ ++ + V E I + + + A L VE TA + G
Sbjct: 3162 YVCLAQNALGTAQKQV-EVIVDTGAMAPGAPQVQAEEAELTVEA-GHTATLRCSATGSPA 3219
Query: 1057 -----KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPE 1108
++ ++ R L I + D G+Y C + AE T+ VE PP
Sbjct: 3220 PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY 3279
Query: 1109 IITRLQNQKVNKGNKATFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIY 1166
T ++ V G + L G +W + GS + + + L
Sbjct: 3280 ATTVPEHASVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPG------RATARNELLHFE 3332
Query: 1167 DCDLDDAGEYSC----EVGNSKCTAILTVEEP 1194
+D+G Y C +VG+++ A L V+ P
Sbjct: 3333 RAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGP 3364
Score = 73.7 bits (173), Expect = 6e-12
Identities = 217/1116 (19%), Positives = 390/1116 (34%), Gaps = 139/1116 (12%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P P+ V G + L CR +P I W +G + P + +D+ +
Sbjct: 1935 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDI----A 1987
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPI-VLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I + G Y VA + G A I V+ + + PP V S V +G+++
Sbjct: 1988 TLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTL 2047
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKAENSE 811
L+ V G+ +TW + +LP + H + P+ D G Y + EN
Sbjct: 2048 DLNCVVAGSAHAQVTWYRRG---GSLPPHT--QVHGSRLRLPQVSPADSGEYVCRVENGS 2102
Query: 812 GIAETSAVITVEEPTEE--------NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
G E S ++V T + P+ I V E T+ L V
Sbjct: 2103 GPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP-SSSHVAEGQTLDLNCVVPGQAHAQ 2161
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+TW++ + P+ T L+ + + DSG+Y C ++G VTI
Sbjct: 2162 VTWHKRGGSL-PARHQTHG------SLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2214
Query: 924 DVE----KVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREIIQ 977
+ + V+ S EG+T+ L C + + WY K + R ++
Sbjct: 2215 EASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY---KRGGSLPARHQVR 2271
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKD-QETSTMLVVKET----IPEFIRKLQDFEVKEKD 1032
R D G C + E S + V T + Q ++
Sbjct: 2272 GSR---LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSS 2328
Query: 1033 VAILE---VEIN-----SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ E +++N A V W + G + P ++ + G + +LY S D
Sbjct: 2329 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL-PVRH----QTHGSLLRLY--QASPADS 2381
Query: 1085 GEYSCILRDESCTAEVTVV-------ELPPEIIT---RLQNQKVNKGNKATFEIE-LTKG 1133
GEY C + S E +V+ +P +T R+++ T ++ L G
Sbjct: 2382 GEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG 2441
Query: 1134 D--ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTA 1187
A V W K G + + + +L++ D+GEY C V G + +
Sbjct: 2442 QAHAQVTWHKRGGSLPARHQVH------GSRLRLLQVTPADSGEYVCRVVGSSGTQEASV 2495
Query: 1188 ILTVEE-------PSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKSVIED 1238
++T+++ + + +R+ AN L + + +TWYK+ +
Sbjct: 2496 LVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS 2555
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV---EFPPKIVDYER 1295
+ V R L I + T D EY C + + + + + V +
Sbjct: 2556 RHQI-----VGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2609
Query: 1296 EYRIKRGSDVTL---LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
RI+ S + +D + I+ K+ + + L + ++
Sbjct: 2610 PIRIESSSPTVVEGQTLDLNCVVARQPQAIIT--WYKRGGSLPSRHQTHGSHLRLHQMSV 2667
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTI---LDKPSPPGKPNILEIDSSSINICWDEPENTGN 1409
D+G Y R NN + + +++ PS PG + I+SSS ++ E E
Sbjct: 2668 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA--EGETLDL 2725
Query: 1410 STIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ ++ Q S+ + +T+ S L S Y + S E +
Sbjct: 2726 NCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASV 2785
Query: 1470 YYKV----IKETKIQSPTVEKPLK----NITTEPNEDIELTCIFGGVPQPKVTWYRDGKK 1521
+ + +P P++ + + ++L C+ G +VTW++ G
Sbjct: 2786 LVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGN 2845
Query: 1522 LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK 1581
L + Y C G +E S +V I+ I +
Sbjct: 2846 LPARHQVH--GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLA 2903
Query: 1582 Q--------KHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRI 1632
Q H + L + V+ G +V WYK G L + + S +R+
Sbjct: 2904 QPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH------GSQLRL 2957
Query: 1633 KELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + S +Y A++ G E + V PS+
Sbjct: 2958 HLVSPADSGEYVCRAASGPGPEQ-EASFTVTVPPSE 2992
Score = 73.3 bits (172), Expect = 9e-12
Identities = 89/415 (21%), Positives = 159/415 (38%), Gaps = 54/415 (13%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TVQ +C G P W R + + + L PED+G + C
Sbjct: 3292 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARN-------ELLHFERAAPEDSGRYRC 3344
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
N G A + +L+V+ P GS I G PT P+ +
Sbjct: 3345 RVTNKVGSAEAFAQLLVQGP---PGS-------------LPATSIPAGSTPTVQVTPQLE 3388
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
G+ + C + + + W +G ++ P ++ VL+I N+ +
Sbjct: 3389 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG----------VLRIQNLDQS 3438
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
+GTY A G+A L I+ + +++++V G +V +G+P+
Sbjct: 3439 CQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV--GHAVEFECLALGDPK 3496
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P +TW K ++ +S G + + ++ D G Y A N+ G ++ ++ V+
Sbjct: 3497 PQVTWSKVGGHLRPGIVQSGG----VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ 3552
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
A P I+ QE+ V + P P I+W + + + P +
Sbjct: 3553 ------ALPQ--ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL---- 3600
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
EN L++ +V + D+G Y C A+N GK A + + V + S+
Sbjct: 3601 --ENNMLMLPSVRPQ-DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSF 3652
Score = 72.9 bits (171), Expect = 1e-11
Identities = 246/1313 (18%), Positives = 454/1313 (34%), Gaps = 176/1313 (13%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G T+ C V G Q+TW+++ + + + L I + P DAG +
Sbjct: 2237 EGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRG-------SRLYIFQASPADAGQYV 2289
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
C A N G +S T + G+ + G +P +
Sbjct: 2290 CRASN--GMEASITVTVT----GTQGANLAYPA---------------GSTQPIRIEPSS 2328
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKK 702
V EG + L C + + W +G S+ + H S+L++
Sbjct: 2329 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGG--------SLPVRHQTHG--SLLRLYQASP 2378
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL-----KSMIVRQGESVILSAQ 757
G Y + +++ I+ P + P S V +G+++ L+
Sbjct: 2379 ADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCL 2438
Query: 758 VVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETS 817
V G +TW K +LP + + +L+ D G Y + S G E S
Sbjct: 2439 VAGQAHAQVTWHKRGG---SLPARHQVHGSRLRLLQVTPA-DSGEYVCRVVGSSGTQEAS 2494
Query: 818 AVITVEEPTE-ENAEPPLFINRFQE--ITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
++T+++ +++ + R + ++ T+ L V +ITWY+ +
Sbjct: 2495 VLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP 2554
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID------VEKV 928
I + L I V + DSG+Y C SN AG VTI V V
Sbjct: 2555 SRHQIVGS------RLRIPQV-TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSV 2607
Query: 929 TFVKHLQKSYETE-EGKTVILECQTSHTVST--KWYHNKKEISGM-----DHREIIQEGR 980
+ ++ S T EG+T+ L C + WY + H + Q
Sbjct: 2608 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSV 2667
Query: 981 XXXXXXXXXXXXDVGVIKC---IVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILE 1037
++ ++ I + ++P I + + + +
Sbjct: 2668 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNC 2727
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
V A V W + G + P + + RG +L + + S D GEY C + S
Sbjct: 2728 VVPGQAHAQVTWHKRGGSL-PSHH----QTRGS--RLRLHHVSPADSGEYVCRVMGSSGP 2780
Query: 1098 AEVTV-----------VELP-----PEIITRLQNQKVNKGNKATFEIELT-KGDALVRWF 1140
E +V V +P P I + +V +G + + + A V W
Sbjct: 2781 LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWH 2840
Query: 1141 KDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT---AILTVEEPSIN 1197
K G + + + + L++ D+GEYSC+V S T ++L EPS
Sbjct: 2841 KRGGNLPARHQVHGPL------LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2894
Query: 1198 FTLRLPEF---ILVPANTDAY-------LTVEIPDET-LDVTWYKKKSVIEDTE------ 1240
+ P I + A++ L +P + VTWYK+ +
Sbjct: 2895 GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ 2954
Query: 1241 -KFTLISDVKKRTLIIRKCT---EDDQCEYTCVLLDAK-STTKLKVEVVEFPPKIVDYER 1295
+ L+S + R + + + +T + ++ S+ +L+ V+ P
Sbjct: 2955 LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPP------ 3008
Query: 1296 EYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENT 1353
+++G D + L+ A P + EW ++ ++ H P+ + +TI +
Sbjct: 3009 SSTVQQGQDASFKCLIHDGAAPI-SLEWKTRNQELEDNVHISPN----GSIITIVGTRPS 3063
Query: 1354 DAGIYKLRLENNCGHADVEMNVTILDKPSP---PGKPNILEIDSSSINICWD--EPENTG 1408
+ G Y+ N G A +N+++ P+ P P +++ + C EP ++
Sbjct: 3064 NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSA 3123
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETT 1468
T I E T + + + I + K + + + A N + A +
Sbjct: 3124 RWTRISSTPAKLEQRTYGLMDSHAVLQ----ISSAKPSDAGTYVCLAQNA--LGTAQKQV 3177
Query: 1469 EYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT 1528
E +P V+ +T E L C G P P + W KL+ +
Sbjct: 3178 EVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHW----SKLR-SPLP 3232
Query: 1529 YENRXXXXXX---XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHK 1585
+++R Y C A + G E + ++ ++ P T E +
Sbjct: 3233 WQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASV--Q 3290
Query: 1586 VGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
G+ + + G PP W + G+ L + ++ + S +Y
Sbjct: 3291 AGETVQLQCLAHGTPPLTFQWSRVGSSLPG------RATARNELLHFERAAPEDSGRYRC 3344
Query: 1646 EASNTAGTSSVEVTLKVYDKP-SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+N G++ L V P S P + VT + + +E A+
Sbjct: 3345 RVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEF-HCAVP 3403
Query: 1705 KHEPDNNRWIKVA---DVDRDVE--TYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
RW K V+ IQ L+++C+ + A P G ++A
Sbjct: 3404 SDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQA 3456
Score = 53.2 bits (122), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 49/435 (11%)
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV-------EFPPKIVDYEREYRIKRGSDV 1305
L I D Y C+ +A T + +VEV+ P++ E E ++ G
Sbjct: 3149 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTA 3208
Query: 1306 TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SIDSKSASLTIKKVENTDAGIYKLRLEN 1364
TL P P W K + P + +L I +V D+G Y +
Sbjct: 3209 TLRCSATGSPAPTIHW-------SKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATS 3261
Query: 1365 NCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
GHA+ + IL SPP + E +S+ G + + + T
Sbjct: 3262 PAGHAEATI---ILHVESPPYATTVPE--HASVQ--------AGETVQLQCLAHGTPPLT 3308
Query: 1425 TEWISVKNITKTQTSIQN-------LKTNSSYRFRAYAVNEVDISDASETTEYYKV---I 1474
+W V + + + +N S R+R N+V ++A +
Sbjct: 3309 FQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL 3368
Query: 1475 KETKI---QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN 1531
T I +PTV+ + T +E C ++ W+++G +L + +
Sbjct: 3369 PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG 3428
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C A G+ + S + IQ P + I+ Q VG
Sbjct: 3429 --VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVE 3486
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ G P P+V W K G L + V+RI ++ + + +Y A+N A
Sbjct: 3487 FECLALGDPKPQVTWSKVGGHLRPG------IVQSGGVVRIAHVELADAGQYRCTATNAA 3540
Query: 1652 GTSSVEVTLKVYDKP 1666
GT+ V L V P
Sbjct: 3541 GTTQSHVLLLVQALP 3555
Score = 46.4 bits (105), Expect = 0.001
Identities = 27/78 (34%), Positives = 34/78 (43%), Gaps = 1/78 (1%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV F C G P P I W I PS + TL+IR+V D G +TC
Sbjct: 400 GQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTC 458
Query: 584 VAKNAAGFASSTTELIVE 601
A NA G + ++E
Sbjct: 459 EAMNARGMVFGIPDGVLE 476
Score = 44.8 bits (101), Expect = 0.003
Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 3/83 (3%)
Query: 734 PPQVIEPLKSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKALP--TKSDGDTHSIT 790
PPQV+ P + I +G++V + +G P P I W N + + P T +
Sbjct: 384 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 443
Query: 791 ILKPKKVKDEGVYTLKAENSEGI 813
I++ K D+G YT +A N+ G+
Sbjct: 444 IIRDVKESDQGAYTCEAMNARGM 466
Score = 42.3 bits (95), Expect = 0.018
Identities = 28/108 (25%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 1550 CIAFNDHGEVETSCV-----VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV 1604
CI + H + E+ C G V+T E I+ G T V G+P P +
Sbjct: 360 CIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR--GQTVTFTCVAIGVPTPII 417
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
W N + + +T++ + I+++K S YT EA N G
Sbjct: 418 NWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 465
Score = 36.7 bits (81), Expect = 0.91
Identities = 66/347 (19%), Positives = 118/347 (34%), Gaps = 13/347 (3%)
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINIC 1400
+ + L V+ +DAG+Y N + + + PS P + E S S+
Sbjct: 1706 QGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPG 1765
Query: 1401 WDEPEN-TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
D T S Y + + + + + +I+N++ + + + N
Sbjct: 1766 ADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMF 1825
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
+ + T V + +P V +T +P + E C G P P + W
Sbjct: 1826 AMDQGTATLH---VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP 1882
Query: 1520 KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ--QKPVITISN 1577
AKA Y C A + G+ V+ + P + +S
Sbjct: 1883 GGQLPAKAQIHG-GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP 1941
Query: 1578 EDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKR 1637
E Q H G + G+P + W K G L + + + + I +
Sbjct: 1942 ER-TQVH-AGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITT 1996
Query: 1638 SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + Y A++ AGT+ + + V S P + E S SVT
Sbjct: 1997 ADAGFYLCVATSPAGTAQARIQVVVL-SASDASPPPVKIESSSPSVT 2042
Score = 35.9 bits (79), Expect = 1.6
Identities = 19/82 (23%), Positives = 39/82 (47%), Gaps = 2/82 (2%)
Query: 1105 LPPEIITRLQNQ-KVNKGNKATFE-IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
+PP+++T + + ++G TF + + ++ W + I + +T +G +
Sbjct: 383 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 442
Query: 1163 LKIYDCDLDDAGEYSCEVGNSK 1184
L I D D G Y+CE N++
Sbjct: 443 LIIRDVKESDQGAYTCEAMNAR 464
Score = 34.7 bits (76), Expect = 3.7
Identities = 22/87 (25%), Positives = 33/87 (37%), Gaps = 5/87 (5%)
Query: 632 IPPTFSKKPKAQY-VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
+PP P+ G + C + +P P I W I ++V E
Sbjct: 383 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR-- 440
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG 717
L I +VK+ +G YT A+N G
Sbjct: 441 --GTLIIRDVKESDQGAYTCEAMNARG 465
>AJ314904-1|CAC85751.1| 658|Homo sapiens obscurin protein.
Length = 658
Score = 112 bits (270), Expect = 1e-23
Identities = 129/601 (21%), Positives = 236/601 (39%), Gaps = 47/601 (7%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
F L+ T + V EC++ P + W + ++ + + + + R
Sbjct: 94 FSRPLQDVVTTEKEKVTLECELSR-PNVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYR 152
Query: 572 EVFPEDAGTFTCVAKNAAGFAS-----STTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
F D G + C A +A AS T LI L++ E+
Sbjct: 153 CEFA-DQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLR- 210
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
++ +P T + + + E +LEC+ V+ + W +E+ P + +
Sbjct: 211 --VKELPVTLVRPLRDKIAMEKHRGVLECQ-VSRASAQVRWFKGSQELQPGPKYELVSDG 267
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
+Y ++ I++V E TYT A + + A + E++ ++ L+ + V
Sbjct: 268 ---LYRKLI-ISDVHAEDEDTYTCDAGDVKTSAQFFV-------EEQSITIVRGLQDVTV 316
Query: 747 RQGESVILSAQV-VGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGV 802
+ + + + RP W ++A + + +G H + + + V
Sbjct: 317 MEPAPAWFECETSIPSVRPP-KWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPV 375
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
+ + G + +SA + V + P + + T +E ++ L P
Sbjct: 376 HF-----TVGKSRSSARLVVSDI------PVVLTRPLEPKTGRELQSVVLSCDFRPAP-K 423
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
++ WY+++ +SPSE + +G+ EL I + D+G Y+C AG + VT
Sbjct: 424 AVQWYKDDTPLSPSEKFKMSLEGQMAELRILRL-MPADAGVYRC----QAGSAHSSTEVT 478
Query: 923 IDVEKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRX 981
++ +VT LQ + TEEG C+ SH +W N + EI +GR
Sbjct: 479 VEAREVTVTGPLQDAEATEEG-WASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRR 537
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
D G+++ TS L V+ F++ L D +E+ L+ E++
Sbjct: 538 HTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVS 597
Query: 1042 SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT 1101
A VVW +DG + P +KYDF R L + + S D G Y+C + E A V
Sbjct: 598 DPEAHVVWRKDGVQLGP-SDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVR 656
Query: 1102 V 1102
V
Sbjct: 657 V 657
Score = 109 bits (263), Expect = 8e-23
Identities = 124/578 (21%), Positives = 218/578 (37%), Gaps = 41/578 (7%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS---DGDTHSIT 790
P PL+ ++ + E V L ++ P + W K+ ++A T + G S+T
Sbjct: 91 PVSFSRPLQDVVTTEKEKVTLECEL-SRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLT 149
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAV----------ITVEEPTE-----ENAE---- 831
I + + D+GVY A +++ A + E+ E ENAE
Sbjct: 150 IYRCE-FADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQ 208
Query: 832 ------PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
P + ++ EK L +V+R + W++ ++ + P DG
Sbjct: 209 LRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASA-QVRWFKGSQELQPGPKYELVSDG 267
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
+L+I++V +E D Y C AG A+ ++ + +T V+ LQ E
Sbjct: 268 LYRKLIISDVHAE-DEDTYTC----DAGDVKTSAQFFVEEQSITIVRGLQ-DVTVMEPAP 321
Query: 946 VILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
EC+TS KW K + + + QEG G + V
Sbjct: 322 AWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGK 381
Query: 1004 QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY 1063
+S LVV + R L+ +E +L + V W +D + P + K+
Sbjct: 382 SRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQWYKDDTPLSPSE-KF 440
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
G + +L I D G Y C + EVTV + LQ+ + +
Sbjct: 441 KMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAREVTVTGPLQDAEATEEGW 500
Query: 1124 ATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
A+F EL+ D V W +G + + +++ G++ L + DAG
Sbjct: 501 ASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKV 560
Query: 1184 KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFT 1243
+A L V + F L + T A L E+ D V W K + ++K+
Sbjct: 561 STSARLEVRVKPVVFLKALDDLSAEERGTLA-LQCEVSDPEAHVVWRKDGVQLGPSDKYD 619
Query: 1244 LISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
+ R L++ + +D YTC + ++ +++V
Sbjct: 620 FLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVRV 657
Score = 99.1 bits (236), Expect = 2e-19
Identities = 127/596 (21%), Positives = 227/596 (38%), Gaps = 56/596 (9%)
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
++ +P +FS+ + E + LEC L + P D+ WL G E+ + +++A +
Sbjct: 86 VVTELPVSFSRPLQDVVTTEKEKVTLECEL-SRPNVDVRWLKDGVELRAGKTMAIAAQGA 144
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPI-----------VLKIKTGE----- 731
C L I + +G Y A + + AS+ + VL GE
Sbjct: 145 ----CRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVA 200
Query: 732 -----------KE-PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP 779
KE P ++ PL+ I + +L QV + W K ++ ++ P
Sbjct: 201 ENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQV-SRASAQVRWFKGSQELQPGP 259
Query: 780 TK---SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFI 836
SDG + I+ +DE YT A G +TSA VEE + +
Sbjct: 260 KYELVSDGLYRKL-IISDVHAEDEDTYTCDA----GDVKTSAQFFVEE------QSITIV 308
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
Q++TV E + V W ++ + +G L++
Sbjct: 309 RGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTC 368
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTV 956
S + + V GKS AR+ + V + L+ E ++V+L C
Sbjct: 369 STMTGPVHFTV-----GKSRSSARLVVSDIPVVLTRPLEPK-TGRELQSVVLSCDFRPAP 422
Query: 957 -STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKET 1015
+ +WY + +S + ++ EG+ D GV +C +ST + V+
Sbjct: 423 KAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEAR 482
Query: 1016 IPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLY 1075
LQD E E+ A E++ E +V W +G + + ++ +G L
Sbjct: 483 EVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLNGMPLY-NDSFHEISHKGRRHTLV 541
Query: 1076 IRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDA 1135
+++ D G S +A + V P + L + + + E++ +A
Sbjct: 542 LKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEVSDPEA 601
Query: 1136 LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTV 1191
V W KDG ++ S+ + L ++D +DAG Y+C VG+ + A + V
Sbjct: 602 HVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHVGSEETRARVRV 657
Score = 97.5 bits (232), Expect = 5e-19
Identities = 88/417 (21%), Positives = 166/417 (39%), Gaps = 10/417 (2%)
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGK 944
G L+ V +E D+G+ + VA N+ + A++ + VT V+ L+ E+ +
Sbjct: 178 GRTYTLIYRRVLAE-DAGEIQFVAENAESR----AQLRVKELPVTLVRPLRDKIAMEKHR 232
Query: 945 TVILECQTSH-TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
V LECQ S + +W+ +E+ E++ +G D C D
Sbjct: 233 GV-LECQVSRASAQVRWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGD 291
Query: 1004 QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKY 1063
+TS V+E +R LQD V E A E E + + G+ +
Sbjct: 292 VKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGNV 351
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
E+ G + +L +R T G + +A + V ++P + L+ + +
Sbjct: 352 GLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQS 411
Query: 1124 ATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
+ V+W+KD + + S +++++G+ +L+I DAG Y C+ G++
Sbjct: 412 VVLSCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSA 471
Query: 1184 KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFT 1243
+ +TVE + T L + A + E+ E +V W + +
Sbjct: 472 HSSTEVTVEAREVTVTGPLQDAEATEEGW-ASFSCELSHEDEEVEWSLNGMPLYNDSFHE 530
Query: 1244 LISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV--VEFPPKIVDYEREYR 1298
+ ++ TL+++ D L ++ +L+V V V F + D E R
Sbjct: 531 ISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFLKALDDLSAEER 587
Score = 95.5 bits (227), Expect = 2e-18
Identities = 89/383 (23%), Positives = 155/383 (40%), Gaps = 6/383 (1%)
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILE 1037
+GR D G I+ + ++ E+ L VKE +R L+D EK +LE
Sbjct: 177 QGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLE 236
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
+++ +A V W + + ++P KY+ G RKL I + DE Y+C D +
Sbjct: 237 CQVSRASAQVRWFKGSQELQPGP-KYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTS 295
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTI 1156
A+ V E I+ LQ+ V + A FE E + +W + +Q ++ L
Sbjct: 296 AQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGNVGLEQ 355
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
+G +L + G VG S+ +A L V + + T L E L
Sbjct: 356 EGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPL-EPKTGRELQSVVL 414
Query: 1217 TVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKST 1276
+ + V WYK + + +EKF + + + L I + D Y C A S+
Sbjct: 415 SCDFRPAPKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSS 474
Query: 1277 TKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP 1336
T++ VE E + E + + + + ++ EW +N + +
Sbjct: 475 TEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHE---DEEVEWSLNGMPLYNDSFHEI 531
Query: 1337 SIDSKSASLTIKKVENTDAGIYK 1359
S + +L +K ++ DAGI +
Sbjct: 532 SHKGRRHTLVLKSIQRADAGIVR 554
Score = 92.3 bits (219), Expect = 2e-17
Identities = 75/310 (24%), Positives = 134/310 (43%), Gaps = 9/310 (2%)
Query: 1068 RGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFE 1127
+G L R D GE + + A++ V ELP ++ L+++ + ++ E
Sbjct: 177 QGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLE 236
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
++++ A VRWFK E+Q +L DG +KL I D +D Y+C+ G+ K +A
Sbjct: 237 CQVSRASAQVRWFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSA 296
Query: 1188 ILTVEEPSINFTLRLPEF-ILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLIS 1246
VEE SI L + ++ PA IP W K+V++ L
Sbjct: 297 QFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIP-SVRPPKWLLGKTVLQAGGNVGLEQ 355
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRG-SDV 1305
+ L++R+ + ++S+ +L VV P ++ E + R V
Sbjct: 356 EGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARL---VVSDIPVVLTRPLEPKTGRELQSV 412
Query: 1306 TLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENN 1365
L D++ P+ +W + + + K S++ + A L I ++ DAG+Y R +
Sbjct: 413 VLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVY--RCQAG 469
Query: 1366 CGHADVEMNV 1375
H+ E+ V
Sbjct: 470 SAHSSTEVTV 479
Score = 80.6 bits (190), Expect = 6e-14
Identities = 48/173 (27%), Positives = 79/173 (45%), Gaps = 1/173 (0%)
Query: 1020 IRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNT 1079
+R LQ E +E+ A +EV+++ D W RDG + + RG + L +
Sbjct: 6 VRGLQAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQQGPTCH-LAVRGPMHTLTLSGL 64
Query: 1080 SVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRW 1139
D G +A + V ELP LQ+ + K T E EL++ + VRW
Sbjct: 65 RPEDSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRW 124
Query: 1140 FKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
KDG E++ + + G + L IY C+ D G Y C+ +++ +A + V+
Sbjct: 125 LKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQ 177
Score = 60.9 bits (141), Expect = 5e-08
Identities = 50/177 (28%), Positives = 68/177 (38%), Gaps = 3/177 (1%)
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXX 985
+V V+ LQ E+G T +E Q SH V W + + G
Sbjct: 2 QVRLVRGLQAVEAREQG-TATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLT 60
Query: 986 XXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETA 1045
D G++ + TS LVV E F R LQD EK+ LE E++
Sbjct: 61 LSGLRPEDSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVTLECELSRPNV 120
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
DV W +DG ++ K +G R L I D+G Y C D +A V V
Sbjct: 121 DVRWLKDGVELRAGKT-MAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKV 176
Score = 58.4 bits (135), Expect = 3e-07
Identities = 41/174 (23%), Positives = 73/174 (41%), Gaps = 1/174 (0%)
Query: 1109 IITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDC 1168
++ LQ + + AT E++L+ D W +DG Q L + G L +
Sbjct: 5 LVRGLQAVEAREQGTATMEVQLSHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGL 64
Query: 1169 DLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVT 1228
+D+G + +A L V E ++F+ L + ++ L E+ +DV
Sbjct: 65 RPEDSGLMVFKAEGVHTSARLVVTELPVSFSRPLQD-VVTTEKEKVTLECELSRPNVDVR 123
Query: 1229 WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
W K + + + + R+L I +C DQ Y C DA+S+ +KV+
Sbjct: 124 WLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQ 177
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+ L PK + +V C P+ + W++ + PS+ F+M + +A L I
Sbjct: 396 VLTRPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQ-MAELRI 453
Query: 571 REVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+ P DAG + C AG A S+TE+ VEA
Sbjct: 454 LRLMPADAGVYRC----QAGSAHSSTEVTVEA 481
Score = 40.3 bits (90), Expect = 0.074
Identities = 52/247 (21%), Positives = 95/247 (38%), Gaps = 11/247 (4%)
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV 895
+ Q + +E+GT + +++ V +W R+ T G L ++ +
Sbjct: 6 VRGLQAVEAREQGTATMEVQLSHADVDG-SWTRDGLRFQQGPTCHLAVRGPMHTLTLSGL 64
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH- 954
E DSG + + G + AR+ + V+F + LQ TE+ K V LEC+ S
Sbjct: 65 RPE-DSG---LMVFKAEGVHT-SARLVVTELPVSFSRPLQDVVTTEKEK-VTLECELSRP 118
Query: 955 TVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVK- 1013
V +W + E+ I +G D GV C D ++S + V+
Sbjct: 119 NVDVRWLKDGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQG 178
Query: 1014 ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T R++ + E E ++ V E +++P ++K EK + +
Sbjct: 179 RTYTLIYRRVLAEDAGEIQFVAENAESRAQLR--VKELPVTLVRPLRDKIAMEKHRGVLE 236
Query: 1074 LYIRNTS 1080
+ S
Sbjct: 237 CQVSRAS 243
Score = 39.1 bits (87), Expect = 0.17
Identities = 38/180 (21%), Positives = 74/180 (41%), Gaps = 11/180 (6%)
Query: 1486 KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA---KATYENRXXXXXXXXXX 1542
+PL+ T + + L+C F P+ V WY+D L + K + E +
Sbjct: 399 RPLEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLM 457
Query: 1543 -XXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y+C A + H E V ++ + V T++ ++ + W +
Sbjct: 458 PADAGVYRCQAGSAHSSTE----VTVEAREV-TVTGP-LQDAEATEEGWASFSCELSHED 511
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
EV W NG L ND + I+ K + + +K ++R+ + + + ++ +EV +K
Sbjct: 512 EEVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVK 571
Score = 39.1 bits (87), Expect = 0.17
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 2/73 (2%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVI 570
+F++ L + T+ +C+V P + W + + PS + + LV+
Sbjct: 574 VFLKALDDLSAEERGTLALQCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTA-GTRGLVV 631
Query: 571 REVFPEDAGTFTC 583
+V PEDAG +TC
Sbjct: 632 HDVSPEDAGLYTC 644
>U35234-1|AAC50299.1| 1948|Homo sapiens protein tyrosine phosphatase
sigma protein.
Length = 1948
Score = 111 bits (266), Expect = 3e-23
Identities = 132/604 (21%), Positives = 232/604 (38%), Gaps = 52/604 (8%)
Query: 1473 VIKETKIQS--PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD----------GK 1520
V++E ++ S P ++ + E + C G P P++TW++D G+
Sbjct: 124 VLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGR 183
Query: 1521 KLKTAKATYEN---RXXXXXXXXXXXXXXXYKCIAFNDHGEVETS----CVVGIQQKPVI 1573
+ T+E+ R Y+C+A N G +S V +++ +
Sbjct: 184 IKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRV 243
Query: 1574 TISNEDIKQKHKV--GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIR 1631
+ H++ G +T V G P P V W + L + + + +V+
Sbjct: 244 APRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPV----GRNVLE 299
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPL 1691
+ ++K S+ YT A ++ G + V P P P++ E + S+TI W
Sbjct: 300 LTDVK--DSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMV-TENTATSITITW---- 352
Query: 1692 DDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE 1751
D G + Y + +++ + D Y I L+ N EY V A N +G +
Sbjct: 353 DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG--Q 410
Query: 1752 ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW-FPSEKNG--GSPIIDYKVEIKQ 1808
SE +V +T P+ + ++ + W P E NG + Y +E +
Sbjct: 411 GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEH 470
Query: 1809 EGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQ 1868
W+ + L + TY R+ A +G P + D I + P Q
Sbjct: 471 PVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDG-PLS--DPIQVKTQQGVPGQ 527
Query: 1869 PRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE 1928
P N + S+TL W+ P I Y + F+ +G ++ + +E
Sbjct: 528 PMNLRAEARSETSITLSWSPPRQES---IIKYELLFR--EGDHGREVGRTFDPTTSYVVE 582
Query: 1929 NIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSW- 1987
++K E FR++A + G+ T VR + PS P ++ V S ++ SW
Sbjct: 583 DLKPNTEYAFRLAARSPQGLGAFT--PVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWR 640
Query: 1988 -GTPEWDGGAPLLGYNIAIRDV--TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
PE GA L+GY++ R + EV + T + + L + Y I A
Sbjct: 641 PPPPETHNGA-LVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAH 699
Query: 2045 NEIG 2048
E+G
Sbjct: 700 TEVG 703
Score = 83.0 bits (196), Expect = 1e-14
Identities = 157/757 (20%), Positives = 286/757 (37%), Gaps = 71/757 (9%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQ 1161
E PP I ++Q G A+F + T GD R W K G ++ + D
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQAT-GDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 1162 K-LKIYDCDLD-DAGEYSCEVGNS--------KCTAILTVEEPSINFTLRL-PEFILVP- 1209
L+I D Y C NS K T + + PS + + P+ +V
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT---------LIIRKCTE 1260
T L + ++TW+K ++ + I ++ T L I E
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEE 208
Query: 1261 DDQCEYTCVLLDA-----KSTTKLKV----EVVEFPPKIVDYEREYRIKRGSDVTLLVDY 1311
DQ +Y CV ++ S L V EV P+ + I G +V +
Sbjct: 209 TDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVA 268
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
P P +W+ ++ + P D ++ + D+ Y ++ G +
Sbjct: 269 VGSPMPYVKWMQGAEDLT------PEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEA 322
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWISV 1430
+T+ P PG P + E ++SI I WD +GN + YYV+EY+ +
Sbjct: 323 VAQITVKSLPKAPGTPMVTENTATSITITWD----SGNPDPVSYYVIEYKSKSQDGPYQI 378
Query: 1431 K-NITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP-TVEKPL 1488
K +IT T+ SI L NS Y AVN + SE+ + ++ +P V+ +
Sbjct: 379 KEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV-VTRTGEQAPASAPRNVQARM 437
Query: 1489 KNITT---EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXX 1545
+ TT + E +E + G + T + K ++
Sbjct: 438 LSATTMIVQWEEPVEPNGLIRGY-RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDET 496
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE-- 1603
+ +AF G+ S IQ K + + + + + E +T + PP +
Sbjct: 497 YTVRVLAFTSVGDGPLS--DPIQVKTQQGVPGQPMNLRAEARSETSIT--LSWSPPRQES 552
Query: 1604 VIWYK-NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK- 1661
+I Y+ + ++ +E T TS + +++LK + + + A + G + ++
Sbjct: 553 IIKYELLFREGDHGREVGRTFDPTTSYV-VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ 611
Query: 1662 --VYDKPSKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEP---DNNRWIK 1715
+ KPS P V + ++ + W+ PP + L Y++ ++ P ++ +
Sbjct: 612 RTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSV-RYRPLGSEDPEPKE 670
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXX 1775
V + ++ L + +Y +A VG ES P+V++T DVPS
Sbjct: 671 VNGIPPTTTQILLEALEKWTQYRITTVAHTEVG--PGPESSPVVVRTDEDVPSAPPRKVE 728
Query: 1776 XXXIDNESVYITWF-PSEKNGGSPIIDYKVE-IKQEG 1810
++ ++ + W P I Y+V ++ EG
Sbjct: 729 AEALNATAIRVLWLGPVPGRQHGQIRGYQVHYVRMEG 765
Score = 82.6 bits (195), Expect = 1e-14
Identities = 81/309 (26%), Positives = 134/309 (43%), Gaps = 30/309 (9%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F K+PK Q G C+ P+P + W KG+++ + IE D
Sbjct: 32 PPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKV--NSQRFETIEFD-ESAG 88
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
+VL+I ++ E Y VA N GE ++ L + ++ P P + + +V +
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG-------DTHSITILK------PK 795
+ + GNP P ITW K+ PV P+ S+G +T T ++
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVD--PSASNGRIKQLRSETFESTPIRGALQIESS 206
Query: 796 KVKDEGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVA 854
+ D+G Y A NS G+ +S A + V E E P F + G + +
Sbjct: 207 EETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITC 266
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+P+P + W + E ++P + + G N+ L +T+V DS +Y CVA +S G
Sbjct: 267 VAVGSPMPYVKWMQGAEDLTPEDDMPV---GRNV-LELTDVK---DSANYTCVAMSSLGV 319
Query: 915 SSHGARVTI 923
A++T+
Sbjct: 320 IEAVAQITV 328
Score = 75.4 bits (177), Expect = 2e-12
Identities = 73/276 (26%), Positives = 120/276 (43%), Gaps = 21/276 (7%)
Query: 717 GEASLPIVLKIK-TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
G L +VL + +EPP+ I+ K I G Q G+P+P +TW K K V
Sbjct: 14 GPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKV 73
Query: 776 KALPTKS---DGDTHSITILKPKKV-KDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ ++ D ++ ++P + +DE VY A+NS G A +TV + +
Sbjct: 74 NSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSG 133
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS-------ETITQNFD 884
P Q V+ T ++ + NP P ITW+++ + PS + ++ F+
Sbjct: 134 FPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFE 193
Query: 885 GENIELVITNVDS-EIDSGDYKCVASNSAG-KSSHGARVTI----DVEKVT-FVKHLQKS 937
I + S E D G Y+CVA+NSAG + S A + + +V +V L S
Sbjct: 194 STPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMS 253
Query: 938 YETEEGKTVILECQT--SHTVSTKWYHNKKEISGMD 971
+E G V + C S KW ++++ D
Sbjct: 254 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPED 289
Score = 70.9 bits (166), Expect = 5e-11
Identities = 80/346 (23%), Positives = 140/346 (40%), Gaps = 39/346 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++ + + G F CQ G P+P++TW ++ + + + +D+ A L
Sbjct: 33 PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 570 IREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I+ + P D + CVA+N+ G E+ V A L+ D
Sbjct: 93 IQPLRTPRDENVYECVAQNSVG------EITVHAKLT-----------------VLREDQ 129
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
L P P+ + V+ + C P+P+I W + P + +
Sbjct: 130 LPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS 189
Query: 689 HMYCSV-----LKITNVKKFQEGTYTVVAVNREG-EASLPI---VLKIKTGEKEPPQV-I 738
+ S L+I + ++ +G Y VA N G S P V +++ + P+ I
Sbjct: 190 ETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 249
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK 798
P+ I+ G +V ++ VG+P P + W + + + T D +L+ VK
Sbjct: 250 LPMSHEIM-PGGNVNITCVAVGSPMPYVKWMQGAEDL----TPEDDMPVGRNVLELTDVK 304
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITV 844
D YT A +S G+ E A ITV+ + P + N IT+
Sbjct: 305 DSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI 350
Score = 56.4 bits (130), Expect = 1e-06
Identities = 83/433 (19%), Positives = 164/433 (37%), Gaps = 38/433 (8%)
Query: 1643 YTIE--ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRE--SVTIEWKPPLDDGGLEL 1698
YT+ A + G + ++V + P P+ +R +R S+T+ W PP + +
Sbjct: 497 YTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQES---I 553
Query: 1699 TKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
KY + E D+ R +V +Y ++ L N EY FR+ A++P G P+
Sbjct: 554 IKYELLFREGDHGR--EVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG---AFTPV 608
Query: 1759 V-IKTALDVPSXXXXXXXXXXIDNESVYITWF--PSEKNGGSPIIDYKVEIKQEGK---- 1811
V +T PS + + ++ ++W P E + G+ ++ Y V + G
Sbjct: 609 VRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGA-LVGYSVRYRPLGSEDPE 667
Query: 1812 -KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR 1870
K ++ L T Y+ A E+G P +S + + + P + PR
Sbjct: 668 PKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPG-PESSPVVVRTDEDV-PSAPPR 725
Query: 1871 NFVVSESTSRSVTLKWTEP-ESNGGSPITNYIIEF---KTVKGKSWTKIVTVGGSVHEHC 1926
+ ++ + W P I Y + + + +G+ +I V + +
Sbjct: 726 KVEAEALNATAIRVLWLGPVPGRQHGQIRGYQVHYVRMEGAEGRGPPRIKDVMLADAQWE 785
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPT---ESQSVRLEKHATVPSPPT---APLEIRMVGS 1980
++ E + +I + E +++ + R + V L ++
Sbjct: 786 TDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPE 845
Query: 1981 NIVMTSWGTPEWDGGAPLLGYNIAI--RDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYM 2038
++ W P +LGY + D T +E + ++ + + TY+
Sbjct: 846 GSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSED---RYTASGVHKGATYV 902
Query: 2039 IRIYARNEIGLSE 2051
R+ AR+ GL E
Sbjct: 903 FRLAARSRGGLGE 915
Score = 43.2 bits (97), Expect = 0.010
Identities = 56/252 (22%), Positives = 96/252 (38%), Gaps = 27/252 (10%)
Query: 1682 SVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRV 1741
S+ W+PP ++ Y ++ D+ + + + Y +++ Y+FR+
Sbjct: 847 SLLARWEPPAGTAEDQVLGYRLQFGREDSTP-LATLEFPPSEDRYTASGVHKGATYVFRL 905
Query: 1742 IAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGS 1797
A++ G E A E I T P +V + W P +E+NG
Sbjct: 906 AARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASA---GTVLLRWLPPVPAERNGA- 961
Query: 1798 PIIDYKVEIKQEGKKWKXXXXXXXXXAR--------IQKLSINTTYQFRIYARNEIGTSL 1849
I+ Y V +++ G A +Q L +T Y ++ A G
Sbjct: 962 -IVKYTVAVREAGALGPARETELPAAAEPGAENAVTLQGLKPDTAYDLQVRAHTRRGPG- 1019
Query: 1850 PYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK---- 1905
P++ + L P+NF V SV L W P+ N SP T Y I++
Sbjct: 1020 PFSPP--VRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPD-NYNSP-TPYKIQYNGLTL 1075
Query: 1906 TVKGKSWTKIVT 1917
V G++ K++T
Sbjct: 1076 DVDGRTTKKLIT 1087
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/115 (21%), Positives = 45/115 (39%), Gaps = 7/115 (6%)
Query: 497 VFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDF 556
++ + E + +AP F G V C G P P + W + + P
Sbjct: 232 LYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPE--- 288
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEM 611
DD V V+ +D+ +TCVA ++ G + ++ V++ G+ M
Sbjct: 289 ----DDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPM 339
>X62515-1|CAA44373.1| 4393|Homo sapiens Human basement membrane
heparan sulfate proteoglycan core protein protein.
Length = 4393
Score = 110 bits (265), Expect = 5e-23
Identities = 177/814 (21%), Positives = 310/814 (38%), Gaps = 104/814 (12%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
PI++E H +G T+ C V G Q+TW+++ + P++ + + L
Sbjct: 2928 PIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL-PARH------QTHGSQLR 2979
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
+ V P D+G + C A G V P S+ GS +
Sbjct: 2980 LHHVSPADSGEYVCRAAGGPG-PEQEASFTVTVPPSE-GSSYRLRS-------------- 3023
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWLFKGEEIVPDENISVAIESDM 688
P S P + V +G D +C + P + W + +E+ ++N+ ++
Sbjct: 3024 ----PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNG-- 3075
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVR 747
S++ I + GTY VA N G A + L + PP V + P + V+
Sbjct: 3076 ----SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHG----PPTVSVLPEGPVWVK 3127
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG--DTHSITILKPKKVKDEGVYTL 805
G++V L G PR + W + + L ++ G D+H++ + K D G Y
Sbjct: 3128 VGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHTVLQISSAKPSDAGTYVC 3187
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A+N+ G A+ + V+ P + E+TV+ T L T +P +I
Sbjct: 3188 LAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE-AELTVEAGHTATLRCSATGSPARTIH 3246
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W +++ SP +G+ L+I V ++ DSG Y C A++ AG + A + + V
Sbjct: 3247 W---SKLRSPLPW-QHRLEGDT--LIIPRV-AQQDSGQYICNATSPAGHAE--ATIILHV 3297
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT--VSTKWYHNKKEISGMDHREIIQEGRXXX 983
E + + + + G+TV L+C T ++ +W + G R
Sbjct: 3298 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR------ATARNEL 3351
Query: 984 XXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE 1043
D G +C V ++ S + + L + ++V E
Sbjct: 3352 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE 3411
Query: 1044 TADVVWERDGEIIKPKKNKYD---FEKRGHIRK--------LYIRNTSVHDEGEYSCILR 1092
T + + P F++ G + L I+N +G Y C
Sbjct: 3412 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3471
Query: 1093 ----DESCTAEVTVVELPPEIIT-RLQNQKVNKGNKATFEIELTKGD--ALVRWFKDGSE 1145
+A++ + LP +I R Q V G+ FE L GD V W K G
Sbjct: 3472 GPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC-LALGDPKPQVTWSKVG-- 3528
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT----AILTVEE-PSINFTL 1200
H++ I ++I +L DAG+Y C N+ T +L V+ P I+
Sbjct: 3529 ----GHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS--- 3581
Query: 1201 RLPEFILVPANTDA-YLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
+P+ + VPA + A + + T D++W K + S ++ L++
Sbjct: 3582 -MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPD------SRLENNMLMLPSVQ 3634
Query: 1260 EDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDY 1293
D Y C + + K ++ P ++V Y
Sbjct: 3635 PQDAGTYVCTATNRQGKVKAFAH-LQVPERVVPY 3667
Score = 93.9 bits (223), Expect = 6e-18
Identities = 258/1251 (20%), Positives = 451/1251 (36%), Gaps = 175/1251 (13%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV+ C+ G P ITW ++ + P Q + ++ATL+I + DAG + C
Sbjct: 1972 GRTVRLYCRAAGVPSATITWRKEGGSLPP----QARSERTDIATLLIPAITTADAGFYLC 2027
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
VA + AG A + +++V + + S+ V +E P+
Sbjct: 2028 VATSPAGTAQARIQVVVLS--ASDASQPPVK--------------IESSSPS-------- 2063
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEI-----VPDENISVAIESDMHMYCSVLKIT 698
V EG + L C + + W +G + V + + S V ++
Sbjct: 2064 -VTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPHHTQVHGSRLRLPQVSPADSGEYVCRVE 2122
Query: 699 NVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQV 758
N +E + TV ++ G S P + G P + IEP S V +G+++ L+ V
Sbjct: 2123 NGSGPKEASITVSVLH--GTHSGPSYTPV-PGSTRPIR-IEP-SSSHVAEGQTLDLNCVV 2177
Query: 759 VGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDEGVYTLKAENSEGIAETS 817
G +TW K +LP + TH S+ L D G Y + G E S
Sbjct: 2178 PGQAHAQVTWHKRG---GSLPARH--QTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEAS 2232
Query: 818 AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
++T+E PP+ I TV E T+ L V +TWY+ +
Sbjct: 2233 VLVTIEASVIPGPIPPVRIES-SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARH 2291
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS-------SHGARVTIDVEKVTF 930
+ G + + S D+G Y C ASN S + GA +
Sbjct: 2292 QVR----GSRLYIFQA---SPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQP 2344
Query: 931 VKHLQKSYETEEGKTVILECQT---SHTVSTKWYH--NKKEISGMDHREIIQEGRXXXXX 985
++ S + EG+T+ L C SH T W+ + H +++ +
Sbjct: 2345 IRIEPSSSQVAEGQTLDLNCVVPGQSHAQVT-WHKRGGSLPVRHQTHGSLLRLYQASPAD 2403
Query: 986 XX----XXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN 1041
V + ++ E + + P + +V E L +
Sbjct: 2404 SGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVA 2463
Query: 1042 SET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
+ A V W + G + P +++ H +L + + D GEY C + S T E
Sbjct: 2464 GQAHAQVTWHKRGGSL-PARHQV------HGSRLRLLQVTPADSGEYVCRVVGSSGTQEA 2516
Query: 1101 TVVELPPEIIT-----------RLQNQKVNKGNKATFEIE---LTKGDALVRWFKDGSEI 1146
+V+ + ++ R+++ + N T ++ ++ + W+K G +
Sbjct: 2517 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL 2576
Query: 1147 QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVEEPSINFTLRL 1202
S H I G +L+I D+GEY C V G+ + + I+T++ + R+
Sbjct: 2577 P-SRH---QIVG--SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPRV 2630
Query: 1203 PEFILVPANTDAYLTVEIPD--------ETLDVTWYKKKSVIEDTE-------KFTLISD 1247
I + +++ + + D +TWYK+ + + +S
Sbjct: 2631 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSV 2690
Query: 1248 VKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL 1307
+ R D E + V+ + S P +I D+
Sbjct: 2691 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNC 2750
Query: 1308 LVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCG 1367
+V QA Q W + T+ S L + V D+G Y R+ + G
Sbjct: 2751 VVPGQAHAQVT--WHKRGGSLPSYHQTRGS------RLRLHHVSPADSGEYVCRVMGSSG 2802
Query: 1368 HADVEMNVTI-------LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
+ + VTI + P+P G P I I+ SS + G + + VV Q
Sbjct: 2803 PLEASVLVTIEASGSSAVHVPAPGGAPPI-RIEPSSSRVA------EGQTLDLKCVVPGQ 2855
Query: 1421 EIDTTEWISVKNITKTQTSIQN--LKTN--SSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
W + + L+ N S Y+ S E + +
Sbjct: 2856 AHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPS 2915
Query: 1477 T--KIQSPTVEKPL----KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE 1530
+ I +P + +P+ + + ++L C+ G +VTWY+ G L T+
Sbjct: 2916 SPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHG 2975
Query: 1531 NRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQ---------QKPVITIS--NE 1578
++ Y C A G E E S V + + PVI+I +
Sbjct: 2976 SQ--LRLHHVSPADSGEYVCRAAGGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS 3033
Query: 1579 DIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRS 1638
++Q + L+ +G P + W +LE+ N+ S+I I + S
Sbjct: 3034 TVQQGQDASFKCLIH---DGAAPISLEWKTRNQELED----NVHISPNGSIITIVGTRPS 3086
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKVYDKPS---KPEGPVIMREISRESVTIE 1686
+ Y ASN G + V L V+ P+ PEGPV ++ ++VT+E
Sbjct: 3087 NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVK--VGKAVTLE 3135
Score = 88.6 bits (210), Expect = 2e-16
Identities = 266/1243 (21%), Positives = 452/1243 (36%), Gaps = 188/1243 (15%)
Query: 505 EQSMAPIFVEKLRPKHT--PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
E + AP+ VE + P + P G + CQV G W R+ PS Q +
Sbjct: 1673 ETNQAPLVVE-VHPARSIVPQGGSHSLRCQVSGRGPHYFYWSREDGRPVPSGTQQRHQGS 1731
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDHGSEMTVXXXXXXXX 621
+ L V P DAG + C +N +S EL+V EAP +TV
Sbjct: 1732 E----LHFPSVQPSDAGVYICTCRNLHRSNTSRAELLVTEAP----SKPITV-----TVE 1778
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G TF K++ + L+ RL P A F G I+ N+
Sbjct: 1779 EQRSQSVRPGADVTFICTAKSK---SPAYTLVWTRLHNGKLPTRAMDFNG--ILTIRNVQ 1833
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPL 741
+ SD Y V +N+ +GT T + V G S P+V PPQ
Sbjct: 1834 L---SDAGTY--VCTGSNMFAMDQGTAT-LHVQASGTLSAPVV------SIHPPQ----- 1876
Query: 742 KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH-SITILKPKKVKDE 800
+ V+ G+ G+P PT+ W P LP K+ H I L + D+
Sbjct: 1877 --LTVQPGQLAEFRCSATGSPTPTLEW--TGGPGGQLPAKA--QIHGGILRLPAVEPTDQ 1930
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
Y +A +S G AV+ V P + ++ + V T++L R P
Sbjct: 1931 AQYLCRAHSSAGQQVARAVLHV----HGGGGPRVQVSP-ERTQVHAGRTVRLYCRAAGVP 1985
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+ITW + + P + +I ++ + D+G Y CVA++ AG + +
Sbjct: 1986 SATITWRKEGGSLPPQ----ARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQ 2041
Query: 921 VTI----DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHRE 974
V + D + VK S EG+T+ L C + + + WY + + H
Sbjct: 2042 VVVLSASDASQPP-VKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWY---RRGGSLPHHT 2097
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKD----QETS-TMLVVKET--------IPEFIR 1021
+ R D G C V++ +E S T+ V+ T +P R
Sbjct: 2098 QVHGSR---LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTR 2154
Query: 1022 KLQ----DFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYI 1076
++ V E L + + A V W + G + P ++ + G + +L+
Sbjct: 2155 PIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-PARH----QTHGSLLRLH- 2208
Query: 1077 RNTSVHDEGEYSCILRDESCTAEVTV-VELPPEII------TRLQNQKVNKGNKATFEIE 1129
+ D GEY C + S E +V V + +I R+++ T ++
Sbjct: 2209 -QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLS 2267
Query: 1130 LT---KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCT 1186
+ A V W+K G + + + + +L I+ DAG+Y C N
Sbjct: 2268 CVVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQASPADAGQYVCRASNGMEA 2321
Query: 1187 AILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD------------VTWYKKKS 1234
+I + L P P + + +TLD VTW+K+
Sbjct: 2322 SITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGG 2381
Query: 1235 VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP------- 1287
+ L + + + D EY C +L + + V V P
Sbjct: 2382 ------SLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPAL 2435
Query: 1288 ---PKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
P + ++ G D+ LV QA Q W + +H
Sbjct: 2436 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVT--WHKRGGSL-PARH-----QVHG 2487
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI---LEIDSSSINI 1399
+ L + +V D+G Y R+ + G + + VTI + S + + I+SSS ++
Sbjct: 2488 SRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASL 2547
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEWI-------SVKNITKTQTSIQNLKTNSSYRFR 1452
G++ + +V Q T W S I ++ I + S +
Sbjct: 2548 A------NGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYV 2601
Query: 1453 AYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEP----NEDIELTCIFGGV 1508
+ N + + ET+ + P V P++ ++ P + ++L C+
Sbjct: 2602 CHVSNG---AGSRETSLIVTIQGSGSSHVPRVSPPIRIESSSPTVVEGQTLDLNCVVARQ 2658
Query: 1509 PQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
PQ +TWY+ G L + T+ + Y C A N+ +E S V+ +
Sbjct: 2659 PQAIITWYKRGGSLPSRHQTHGSH--LRLHQMSVADSGEYVCRANNNIDALEASIVISVS 2716
Query: 1569 Q---KPVITISNEDIK----QKHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
P S+ I+ H E L + V+ G +V W+K G L + Y+
Sbjct: 2717 PSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPS---YH 2773
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAG--TSSVEVTLK 1661
T + S +R+ + + S +Y ++G +SV VT++
Sbjct: 2774 QT---RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2813
Score = 87.4 bits (207), Expect = 5e-16
Identities = 207/1007 (20%), Positives = 356/1007 (35%), Gaps = 120/1007 (11%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G+ PT + + V EG + L C + + W +G ++ + +
Sbjct: 2436 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGG----------SLPARHQV 2485
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLK----SM 744
+ S L++ V G Y V G EAS+ + ++ + V P++ S
Sbjct: 2486 HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSA 2545
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD--GDTHSITILKPKKVKDEGV 802
+ G ++ L+ V TITW K +LP++ G I + P D G
Sbjct: 2546 SLANGHTLDLNCLVASQAPHTITWYKRG---GSLPSRHQIVGSRLRIPQVTP---ADSGE 2599
Query: 803 YTLKAENSEGIAETSAVITVEEPTEEN---AEPPLFINRFQEITVKEKGTIKLVARVTRN 859
Y N G ETS ++T++ + PP+ I TV E T+ L V R
Sbjct: 2600 YVCHVSNGAGSRETSLIVTIQGSGSSHVPRVSPPIRIES-SSPTVVEGQTLDLNCVVARQ 2658
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P ITWY+ + PS T G ++ L + S DSG+Y C A+N+
Sbjct: 2659 PQAIITWYKRGGSL-PSRHQTH---GSHLRL---HQMSVADSGEYVCRANNNIDALEASI 2711
Query: 920 RVTIDVE--------KVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKW-------- 960
+++ ++ S EG+T+ L C +H T W
Sbjct: 2712 VISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVT-WHKRGGSLP 2770
Query: 961 -YHNKK-EISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPE 1018
YH + + H G + V+ I ++ + P
Sbjct: 2771 SYHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP 2830
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSET-ADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
+ V E L+ + + A V W + G + P +++ H L +
Sbjct: 2831 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL-PARHQV------HGPLLRLN 2883
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTV-VELPPE-------------IITRLQNQKVNKGNK 1123
S D GEYSC + S T E +V V + P I + V +G
Sbjct: 2884 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2943
Query: 1124 ATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ + A V W+K G + + H +L+++ D+GEY C
Sbjct: 2944 LDLNCVVPGQAHAQVTWYKRGGSLP-ARH-----QTHGSQLRLHHVSPADSGEYVCRAAG 2997
Query: 1183 S---KCTAILTVEEP---SINFTLRLPEFILVPANT------DAYLTVEIPD--ETLDVT 1228
+ A TV P ++ LR P + P ++ DA I D + +
Sbjct: 2998 GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLE 3057
Query: 1229 WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFP 1287
W + +ED + + + I + Y CV +A + V + V P
Sbjct: 3058 WKTRNQELEDNVHISPNGSI----ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3113
Query: 1288 PKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI-VNSKIIKKCKHTKPSIDSKSASL 1345
P + V E +K G VTL P+ + W ++S K + T +DS + L
Sbjct: 3114 PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHTV-L 3172
Query: 1346 TIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPE 1405
I + +DAG Y +N G A ++ V + PG P + + + + + +
Sbjct: 3173 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV-QAEEAELTV------ 3225
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G++ + T W +++ Q ++ T R + I +A+
Sbjct: 3226 EAGHTATLRCSATGSPARTIHWSKLRSPLPWQHRLEG-DTLIIPRVAQQDSGQY-ICNAT 3283
Query: 1466 ETTEYYKVIKETKIQSPTVEKPL-KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKT 1524
+ + ++SP + ++ + + E ++L C+ G P W R G L
Sbjct: 3284 SPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL-P 3342
Query: 1525 AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
+AT N Y+C N G E + +Q P
Sbjct: 3343 GRATARNE-LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP 3388
Score = 79.0 bits (186), Expect = 2e-13
Identities = 161/753 (21%), Positives = 273/753 (36%), Gaps = 90/753 (11%)
Query: 472 QYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFEC 531
+Y+ NN L+ + I P P++ SM PI +E H +G T+ C
Sbjct: 2695 EYVCRANNNIDALEASI--VISVSPSAGSPSAPGSSM-PIRIES-SSSHVAEGETLDLNC 2750
Query: 532 QVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGF 591
V G Q+TW ++ + PS Y + L + V P D+G + C ++G
Sbjct: 2751 VVPGQAHAQVTWHKRGGSL-PS------YHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2803
Query: 592 ASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDI 651
++ + +EA GS G PP +P + V EG +
Sbjct: 2804 LEASVLVTIEA----SGS------------SAVHVPAPGGAPP-IRIEPSSSRVAEGQTL 2846
Query: 652 LLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV 711
L+C + + W +G + P + ++ +L++ V G Y+
Sbjct: 2847 DLKCVVPGQAHAQVTWHKRGGNL-PARH---------QVHGPLLRLNQVSPADSGEYSCQ 2896
Query: 712 AVNREGEASLPIVLKIKTGEKEP---PQVIEPL----KSMIVRQGESVILSAQVVGNPRP 764
G +++ I+ P P + +P+ S V +G+++ L+ V G
Sbjct: 2897 VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHA 2956
Query: 765 TITWCKNNKPVKALPTKSDGDTHSITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
+TW K +LP + TH + L D G Y +A G E A TV
Sbjct: 2957 QVTWYKRG---GSLPARH--QTHGSQLRLHHVSPADSGEYVCRAAGGPG-PEQEASFTVT 3010
Query: 824 EPTEENA----EPPLFINRFQEITVKEKGTIKLVARVTRNPVP-SITWYRNNEIISPSET 878
P E + P+ TV++ + P S+ W N+ + +
Sbjct: 3011 VPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVH 3070
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS- 937
I+ N G I +V T + G Y+CVASN+ G + + V + V V L +
Sbjct: 3071 ISPN--GSIITIVGTRPSNH---GTYRCVASNAYGVAQ--SVVNLSVHGPPTVSVLPEGP 3123
Query: 938 YETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVG 995
+ GK V LEC ++ S +W + ++ R D G
Sbjct: 3124 VWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHTVLQISSAKPSDAG 3183
Query: 996 VIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEI 1055
C+ ++ + V E I + + + A L VE TA + G
Sbjct: 3184 TYVCLAQNALGTAQKQV-EVIVDTGAMAPGAPQVQAEEAELTVEA-GHTATLRCSATGSP 3241
Query: 1056 IK-----PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPP 1107
+ ++ ++ R L I + D G+Y C + AE T+ VE PP
Sbjct: 3242 ARTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPP 3301
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
T ++ V G + L G +W + GS + + + L
Sbjct: 3302 YATTVPEHASVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPG------RATARNELLHF 3354
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEP 1194
+D+G Y C +VG+++ A L V+ P
Sbjct: 3355 ERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGP 3387
Score = 77.4 bits (182), Expect = 5e-13
Identities = 237/1247 (19%), Positives = 431/1247 (34%), Gaps = 144/1247 (11%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD 561
++ + S P+ +E P T +G T+ C V G Q+TW+R+ + ++
Sbjct: 2046 SASDASQPPVKIESSSPSVT-EGQTLDLNCVVAGSAHAQVTWYRRGGSLP-------HHT 2097
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
+ + L + +V P D+G + C +N +G ++ + V HG+
Sbjct: 2098 QVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVL-----HGTHSGPSYTP---- 2148
Query: 622 XXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENIS 681
+ G +P + +V EG + L C + + W +G
Sbjct: 2149 -------VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG--------- 2192
Query: 682 VAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIE 739
++ + + S+L++ V G Y V G EAS+ + ++ P V
Sbjct: 2193 -SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRI 2251
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
S V +G+++ LS V G +TW K +LP + + I + D
Sbjct: 2252 ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRG---GSLPARHQVRGSRLYIFQASPA-D 2307
Query: 800 EGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-----TVKEKGTIKLVA 854
G Y +A N E S +TV N P + I V E T+ L
Sbjct: 2308 AGQYVCRASNG---MEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNC 2364
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
V +TW++ S + G + L S DSG+Y C S+
Sbjct: 2365 VVPGQSHAQVTWHKR----GGSLPVRHQTHGSLLRLYQA---SPADSGEYVCRVLGSSVP 2417
Query: 915 SSHGARVTID-------VEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEI 967
VTI+ + V+ S + EG+T+ L C + + +K+
Sbjct: 2418 LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG- 2476
Query: 968 SGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV----KDQETSTMLVVKETIPEFIRKL 1023
+ R + R D G C V QE S ++ +++ + +
Sbjct: 2477 GSLPARHQVHGSR---LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQG 2533
Query: 1024 QDFEVK-EKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHI--RKLYIRNTS 1080
+ V+ E A L + +V + I K R I +L I +
Sbjct: 2534 VAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVT 2593
Query: 1081 VHDEGEYSCILRDESCTAEVTVV------------ELPPEIITRLQNQKVNKGNKATFE- 1127
D GEY C + + + + E +++ + P I + V +G
Sbjct: 2594 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPRVSPPIRIESSSPTVVEGQTLDLNC 2653
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS---- 1183
+ + A++ W+K G + S H L+++ + D+GEY C N+
Sbjct: 2654 VVARQPQAIITWYKRGGSLP-SRH-----QTHGSHLRLHQMSVADSGEYVCRANNNIDAL 2707
Query: 1184 KCTAILTV-------EEPSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKS 1234
+ + +++V P + +R+ A + L +P + VTW+K+
Sbjct: 2708 EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGG 2767
Query: 1235 VI---EDTEKFTL----ISDVKKRTLIIRKCTEDDQCEYT-CVLLDAKSTTKLKVEVVEF 1286
+ T L +S + R E + V ++A ++ + V
Sbjct: 2768 SLPSYHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2827
Query: 1287 PPKIVDYEREYRIKRGS--DVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
P I R+ G D+ +V QA Q W K+ +
Sbjct: 2828 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT--W------HKRGGNLPARHQVHGPL 2879
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTI-LDKPSP---PGKPNILEIDSSSINIC 1400
L + +V D+G Y ++ + G + + VTI P P PG + I++SS ++
Sbjct: 2880 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV- 2938
Query: 1401 WDEPENTGNSTIIYYVVEYQEIDTTEWI----SVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
G + + VV Q W S+ +T S L S Y
Sbjct: 2939 -----TEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHHVSPADSGEYVC 2993
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI-----TTEPNEDIELTC-IFGGVPQ 1510
+ + + ++ S + P+ +I T + +D C I G
Sbjct: 2994 RAAGGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3053
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQK 1570
+ W ++L+ N Y+C+A N +G ++ + +
Sbjct: 3054 ISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3113
Query: 1571 PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVI 1630
P +++ E KVG + V G P W + + ++ + +V+
Sbjct: 3114 PTVSVLPEG-PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHTVL 3172
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMRE 1677
+I K S + Y A N GT+ +V + V P P + E
Sbjct: 3173 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE 3219
Score = 74.1 bits (174), Expect = 5e-12
Identities = 89/415 (21%), Positives = 159/415 (38%), Gaps = 54/415 (13%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TVQ +C G P W R + + + L PED+G + C
Sbjct: 3315 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARN-------ELLHFERAAPEDSGRYRC 3367
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
N G A + +L+V+ P GS I G PT P+ +
Sbjct: 3368 RVTNKVGSAEAFAQLLVQGP---PGS-------------LPATSIPAGSTPTVQVTPQLE 3411
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
G+ + C + + + W +G ++ P ++ VL+I N+ +
Sbjct: 3412 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG----------VLRIQNLDQS 3461
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
+GTY A G+A L I+ + +++++V G +V +G+P+
Sbjct: 3462 CQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV--GHAVEFECLALGDPK 3519
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P +TW K ++ +S G + + ++ D G Y A N+ G ++ ++ V+
Sbjct: 3520 PQVTWSKVGGHLRPGIVQSGG----VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ 3575
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
A P I+ QE+ V + P P I+W + + + P +
Sbjct: 3576 ------ALPQ--ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL---- 3623
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
EN L++ +V + D+G Y C A+N GK A + + V + S+
Sbjct: 3624 --ENNMLMLPSVQPQ-DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSF 3675
Score = 73.7 bits (173), Expect = 6e-12
Identities = 222/1121 (19%), Positives = 392/1121 (34%), Gaps = 149/1121 (13%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P P+ V G + L CR +P I W +G + P + +D+ +
Sbjct: 1958 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDI----A 2010
Query: 694 VLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
L I + G Y VA + G +A + +V+ + +PP IE S V +G++
Sbjct: 2011 TLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASQPPVKIES-SSPSVTEGQT 2069
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPK-KVKDEGVYTLKAENS 810
+ L+ V G+ +TW + +LP + H + P+ D G Y + EN
Sbjct: 2070 LDLNCVVAGSAHAQVTWYRRG---GSLPHHT--QVHGSRLRLPQVSPADSGEYVCRVENG 2124
Query: 811 EGIAETSAVITVEEPTEE--------NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
G E S ++V T + P+ I V E T+ L V
Sbjct: 2125 SGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP-SSSHVAEGQTLDLNCVVPGQAHA 2183
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+TW++ + P+ T L+ + + DSG+Y C ++G VT
Sbjct: 2184 QVTWHKRGGSL-PARHQTHG------SLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVT 2236
Query: 923 IDVE----KVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGMDHREII 976
I+ + V+ S EG+T+ L C + + WY K + R +
Sbjct: 2237 IEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY---KRGGSLPARHQV 2293
Query: 977 QEGRXXXXXXXXXXXXDVGVIKCIVKD-QETSTMLVVKET----IPEFIRKLQDFEVKEK 1031
+ R D G C + E S + V T + Q ++
Sbjct: 2294 RGSR---LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPS 2350
Query: 1032 DVAILE---VEIN-----SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHD 1083
+ E +++N A V W + G + P ++ + G + +LY S D
Sbjct: 2351 SSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL-PVRH----QTHGSLLRLY--QASPAD 2403
Query: 1084 EGEYSCILRDESCTAEVTVV-------ELPPEIIT---RLQNQKVNKGNKATFEIE-LTK 1132
GEY C + S E +V+ +P +T R+++ T ++ L
Sbjct: 2404 SGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVA 2463
Query: 1133 GD--ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCT 1186
G A V W K G + + + +L++ D+GEY C V G + +
Sbjct: 2464 GQAHAQVTWHKRGGSLPARHQVH------GSRLRLLQVTPADSGEYVCRVVGSSGTQEAS 2517
Query: 1187 AILTVEE-------PSINFTLRLPEFILVPANTDAY-LTVEIPDET-LDVTWYKKKSVIE 1237
++T+++ + + +R+ AN L + + +TWYK+ +
Sbjct: 2518 VLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP 2577
Query: 1238 DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKST--TKLKV--------EVVEFP 1287
+ V R L I + T D EY C + + + T L V V
Sbjct: 2578 SRHQI-----VGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPRVS 2631
Query: 1288 PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTI 1347
P I + G + L PQ W + +H + + L +
Sbjct: 2632 PPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS-RH-----QTHGSHLRL 2685
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTI---LDKPSPPGKPNILEIDSSSINICWDEP 1404
++ D+G Y R NN + + +++ PS PG + I+SSS ++ E
Sbjct: 2686 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA--EG 2743
Query: 1405 ENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDA 1464
E + ++ Q S+ + +T+ S L S Y + S
Sbjct: 2744 ETLDLNCVVPGQAHAQVTWHKRGGSLPSYHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2803
Query: 1465 SETTEYYKV----IKETKIQSPTVEKPLK----NITTEPNEDIELTCIFGGVPQPKVTWY 1516
E + + + +P P++ + + ++L C+ G +VTW+
Sbjct: 2804 LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWH 2863
Query: 1517 RDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITIS 1576
+ G L + Y C G +E S +V I+ I
Sbjct: 2864 KRGGNLPARHQVH--GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIP 2921
Query: 1577 NEDIKQ--------KHKVGDEWL-VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKT 1627
+ Q H + L + V+ G +V WYK G L + +
Sbjct: 2922 APGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH------G 2975
Query: 1628 SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
S +R+ + + S +Y A+ G E + V PS+
Sbjct: 2976 SQLRLHHVSPADSGEYVCRAAGGPGPEQ-EASFTVTVPPSE 3015
Score = 50.0 bits (114), Expect = 9e-05
Identities = 130/638 (20%), Positives = 216/638 (33%), Gaps = 74/638 (11%)
Query: 1070 HIRKLYIRNTSVHDEGEYSCIL-------RDESCTAEVTVVE------LPPEIITRLQNQ 1116
H +L + + S D GEY C ++ S T V E P I +
Sbjct: 2974 HGSQLRLHHVSPADSGEYVCRAAGGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS 3033
Query: 1117 KVNKGNKATFEIELTKGDALV--RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAG 1174
V +G A+F+ + G A + W E++ + HI + I + G
Sbjct: 3034 TVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS----PNGSIITIVGTRPSNHG 3089
Query: 1175 EYSCEVGNSKCTAILTVE-----EPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
Y C N+ A V P+++ P ++ V V + W
Sbjct: 3090 TYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKV-GKAVTLECVSAGEPRSSARW 3148
Query: 1230 YKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV----- 1284
+ S E+ T L I D Y C+ +A T + +VEV+
Sbjct: 3149 TRISSTPAKLEQRTYGLMDSHTVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGA 3208
Query: 1285 --EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKP-SIDSK 1341
P++ E E ++ G TL P W K + P +
Sbjct: 3209 MAPGAPQVQAEEAELTVEAGHTATLRCSATGSPARTIHW-------SKLRSPLPWQHRLE 3261
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
+L I +V D+G Y + GHA+ + IL SPP + E +S+
Sbjct: 3262 GDTLIIPRVAQQDSGQYICNATSPAGHAEATI---ILHVESPPYATTVPE--HASVQ--- 3313
Query: 1402 DEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN-------LKTNSSYRFRAY 1454
G + + + T +W V + + + +N S R+R
Sbjct: 3314 -----AGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCR 3368
Query: 1455 AVNEVDISDASETTEYYKV---IKETKI---QSPTVEKPLKNITTEPNEDIELTCIFGGV 1508
N+V ++A + T I +PTV+ + T +E C
Sbjct: 3369 VTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSD 3428
Query: 1509 PQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
++ W+++G +L + + Y C A G+ + S + IQ
Sbjct: 3429 RGTQLRWFKEGGQLPPGHSVQDG--VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQ 3486
Query: 1569 QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS 1628
P + I+ Q VG + G P P+V W K G L +
Sbjct: 3487 ALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG------IVQSGG 3540
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
V+RI ++ + + +Y A+N AGT+ V L V P
Sbjct: 3541 VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALP 3578
Score = 44.4 bits (100), Expect = 0.005
Identities = 26/78 (33%), Positives = 35/78 (44%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV F C G P P + +R PSQ + TL+IR+V D G +TC
Sbjct: 421 GQTVTFTCVAIGVPAPFLINWRLNWGHIPSQPRVTVTSEGGRGTLIIRDVKESDQGAYTC 480
Query: 584 VAKNAAGFASSTTELIVE 601
A NA G + ++E
Sbjct: 481 EAMNARGMVFGIPDGVLE 498
Score = 40.7 bits (91), Expect = 0.056
Identities = 26/85 (30%), Positives = 44/85 (51%), Gaps = 6/85 (7%)
Query: 734 PPQVIEPLKSMI-VRQGESVILSAQVVGNPRP-TITWCKNNKPVKALP---TKSDGDTHS 788
PPQV+ P + I +G++V + +G P P I W N + + P S+G +
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPAPFLINWRLNWGHIPSQPRVTVTSEGGRGT 464
Query: 789 ITILKPKKVKDEGVYTLKAENSEGI 813
+ I++ K D+G YT +A N+ G+
Sbjct: 465 L-IIRDVKESDQGAYTCEAMNARGM 488
Score = 40.3 bits (90), Expect = 0.074
Identities = 29/109 (26%), Positives = 45/109 (41%), Gaps = 8/109 (7%)
Query: 1550 CIAFNDHGEVETSCV-----VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV 1604
CI + H + E+ C G V+T E I+ G T V G+P P +
Sbjct: 381 CIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR--GQTVTFTCVAIGVPAPFL 438
Query: 1605 I-WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
I W N + + +T++ + I+++K S YT EA N G
Sbjct: 439 INWRLNWGHIPSQPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 487
Score = 37.5 bits (83), Expect = 0.52
Identities = 66/347 (19%), Positives = 119/347 (34%), Gaps = 13/347 (3%)
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINIC 1400
+ + L V+ +DAG+Y N + + + PS P + E S S+
Sbjct: 1729 QGSELHFPSVQPSDAGVYICTCRNLHRSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPG 1788
Query: 1401 WDEPEN-TGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
D T S Y + + + + + +I+N++ + + + N
Sbjct: 1789 ADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMF 1848
Query: 1460 DISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG 1519
+ + T V + +P V +T +P + E C G P P + W
Sbjct: 1849 AMDQGTATLH---VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP 1905
Query: 1520 KKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ--QKPVITISN 1577
AKA Y C A + G+ V+ + P + +S
Sbjct: 1906 GGQLPAKAQIHG-GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP 1964
Query: 1578 EDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKR 1637
E Q H G + G+P + W K G L + + + + I +
Sbjct: 1965 ER-TQVH-AGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITT 2019
Query: 1638 SHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVT 1684
+ + Y A++ AGT+ + + V + PV + E S SVT
Sbjct: 2020 ADAGFYLCVATSPAGTAQARIQVVVLSASDASQPPVKI-ESSSPSVT 2065
Score = 35.1 bits (77), Expect = 2.8
Identities = 21/83 (25%), Positives = 38/83 (45%), Gaps = 3/83 (3%)
Query: 1105 LPPEIITRLQNQ-KVNKGNKATFEIELTKGDA--LVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
+PP+++T + + ++G TF A L+ W + I + +T +G +
Sbjct: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPAPFLINWRLNWGHIPSQPRVTVTSEGGRG 463
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSK 1184
L I D D G Y+CE N++
Sbjct: 464 TLIIRDVKESDQGAYTCEAMNAR 486
>AK129856-1|BAC85243.1| 295|Homo sapiens protein ( Homo sapiens cDNA
FLJ26346 fis, clone HRT04038, highly similar to Homo
sapiens titin (TTN), transcript variant N2-B. ).
Length = 295
Score = 109 bits (261), Expect = 1e-22
Identities = 71/215 (33%), Positives = 104/215 (48%), Gaps = 6/215 (2%)
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNY 1900
A N+ G P S+ + + PP P+N V+ T S+ + W P+S+GGS I NY
Sbjct: 2 AVNKYGVGEPLESEPVLAVNP-YGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINY 60
Query: 1901 IIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLE 1960
I+E + G+ W K + + + + E E FRI AEN G+S P+ + S +
Sbjct: 61 IVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPT-SPFYK 119
Query: 1961 KHATV--PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK 2018
TV P PP P + S+I + +W P +DGG+ + GY + I + W V
Sbjct: 120 ACDTVFKPGPPGNPRVLDTSRSSISI-AWNKPIYDGGSEITGYMVEIALPEEDEWQIVTP 178
Query: 2019 -VDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
+ + I L+EN Y IRIYA N GL EP
Sbjct: 179 PAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEP 213
Score = 89.8 bits (213), Expect = 9e-17
Identities = 63/215 (29%), Positives = 97/215 (45%), Gaps = 7/215 (3%)
Query: 1742 IAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIID 1801
+A N G E LESEP++ P I +S+ + W + +GGS II+
Sbjct: 1 MAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTT-ITKDSMVVCWGHPDSDGGSEIIN 59
Query: 1802 YKVEIKQE-GKKWKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKIT 1858
Y VE + + G++W R + L+ Y+FRI A N G S P +
Sbjct: 60 YIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYK 119
Query: 1859 IGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT- 1917
T+ P P N V +++ S+++ W +P +GGS IT Y++E + W +IVT
Sbjct: 120 ACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEW-QIVTP 178
Query: 1918 -VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLP 1951
G + I + E E RI A N+ G+ P
Sbjct: 179 PAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEP 213
Score = 79.4 bits (187), Expect = 1e-13
Identities = 55/192 (28%), Positives = 77/192 (40%), Gaps = 5/192 (2%)
Query: 1663 YDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
Y P P+ P + I+++S+ + W P DGG E+ Y +E+ + RWIK
Sbjct: 23 YGPPDPPKNPEVTT-ITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLT 81
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNE 1782
Y + L E EY FR++A+N G S + P
Sbjct: 82 DLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVLDTSRS 141
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIK-QEGKKWKXXXXXXXXXA---RIQKLSINTTYQFR 1838
S+ I W +GGS I Y VEI E +W+ A I L+ N Y+ R
Sbjct: 142 SISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIR 201
Query: 1839 IYARNEIGTSLP 1850
IYA N G P
Sbjct: 202 IYAMNSEGLGEP 213
Score = 73.7 bits (173), Expect = 6e-12
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 1942 AENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGY 2001
A N GV P ES+ V P PP P E+ + + ++ WG P+ DGG+ ++ Y
Sbjct: 2 AVNKYGVGEPLESEPVLAVNPYGPPDPPKNP-EVTTITKDSMVVCWGHPDSDGGSEIINY 60
Query: 2002 NIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
+ RD W++ K + L++ + L+E H Y RI A N G+S P + +K
Sbjct: 61 IVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYK 119
Score = 71.3 bits (167), Expect = 3e-11
Identities = 42/128 (32%), Positives = 59/128 (46%), Gaps = 8/128 (6%)
Query: 1631 RIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD------KPSKPEGPVIMREISRESVT 1684
++ L H ++ I A N AG S+ T Y KP P P ++ + SR S++
Sbjct: 86 KVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPGPPGNPRVL-DTSRSSIS 144
Query: 1685 IEWKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
I W P+ DGG E+T Y +E P+ + W I +Y I L EN EY R+ A
Sbjct: 145 IAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYA 204
Query: 1744 QNPVGFSE 1751
N G E
Sbjct: 205 MNSEGLGE 212
Score = 70.1 bits (164), Expect = 8e-11
Identities = 49/159 (30%), Positives = 71/159 (44%), Gaps = 9/159 (5%)
Query: 1380 KPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV---KNITKT 1436
KP PPG P +L+ SSI+I W++P G S I Y+VE + EW V + T
Sbjct: 126 KPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKAT 185
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL---KNITT 1493
+I L N Y+ R YA+N + + + K E ++ P +E K +T
Sbjct: 186 SYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKA--EDRMLPPEIELDADLRKVVTI 243
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRD-GKKLKTAKATYEN 1531
+ L G P P+V W RD G+ L A +N
Sbjct: 244 RACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIAPKN 282
Score = 66.1 bits (154), Expect = 1e-09
Identities = 32/94 (34%), Positives = 46/94 (48%), Gaps = 2/94 (2%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWI--SVKNITKTQT 1438
P PP P + I S+ +CW P++ G S II Y+VE ++ WI + K +T +
Sbjct: 26 PDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRY 85
Query: 1439 SIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
+ L Y FR A N IS S T+ +YK
Sbjct: 86 KVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYK 119
>X76132-1|CAA53735.1| 1447|Homo sapiens tumour suppressor protein.
Length = 1447
Score = 108 bits (260), Expect = 2e-22
Identities = 125/585 (21%), Positives = 221/585 (37%), Gaps = 34/585 (5%)
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXX 1541
+++P N+ +D L C G P P TW R + +L++ K +
Sbjct: 243 LQRP-SNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVT 301
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C+ + + S + + P ++ + E+ T + G P
Sbjct: 302 DDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECT--VSGKPV 359
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P V W KNG+ + + I S +RI + +S Y A N AG + L
Sbjct: 360 PTVNWMKNGDVVIPSDYFQIV---GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQL- 415
Query: 1662 VYDKPSKPEGPVIMRE--------ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW 1713
+ KP+ P V+ +S V + W+PP + G T E DN
Sbjct: 416 IVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRER 475
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
++ + L Y FRV+A N G E+ + + + L VP
Sbjct: 476 ALNTTQPGSLQ-LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENL 534
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINT 1833
S+ ITW P G P+ Y++ + + +++ L T
Sbjct: 535 QAVST-SPTSILITWEPPAYANG-PVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFT 592
Query: 1834 TYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNG 1893
Y R A N G + ++DD + + P + P+N + SRS+ + W P S
Sbjct: 593 EYSLRFLAYNRYGPGV--STDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT 650
Query: 1894 GSP-ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
+ IT Y I + + ++ T+ + + +++ + F++SA G P+
Sbjct: 651 QNGFITGYKIRHRKTTRRG--EMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPS 708
Query: 1953 ESQSVRLEKH----ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDV 2008
+ ++ + VP P++ L +R +N ++ SW TP + + GY I
Sbjct: 709 NWYTAETPENDLDESQVPDQPSS-LHVR-PQTNCIIMSW-TPPLNPNIVVRGYIIGYG-- 763
Query: 2009 TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
+ + E +VD ++I L + Y+I + A N G PL
Sbjct: 764 VGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPL 808
Score = 78.6 bits (185), Expect = 2e-13
Identities = 94/393 (23%), Positives = 151/393 (38%), Gaps = 22/393 (5%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPE-PDIAWLFKGEEIVPDENISVAIESDMHMYCSV 694
F +P G ++LL+C + P I W G + + S+ +
Sbjct: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQN 101
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVIL 754
+ + K EG Y A G++ I K P + + +S+ G++V+L
Sbjct: 102 ILHSRHHKPDEGLYQCEA--SLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
Query: 755 SAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAENSEG 812
+V+G P PTI W KN + + +P S L+ +++ D G+Y A N
Sbjct: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
Query: 813 IAETSAVITVEEPTEENAEPPL-FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+ T V ++ L F+ R + E L V+ P PS TW R E
Sbjct: 220 -SRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEE 278
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV 931
+I G N L+I+NV + DSG Y CV + S A +T+ V F+
Sbjct: 279 VIQLRSKKYSLLGGSN--LLISNVTDD-DSGMYTCVVTYKNENISASAELTVLVPP-WFL 334
Query: 932 KHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
H Y E + EC S + W N + D+ +I+
Sbjct: 335 NHPSNLY-AYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV---GGSNLRILGV 390
Query: 990 XXXDVGVIKCIVKDQ----ETSTMLVV-KETIP 1017
D G +C+ +++ +TS L+V K IP
Sbjct: 391 VKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP 423
Score = 68.9 bits (161), Expect = 2e-10
Identities = 95/443 (21%), Positives = 174/443 (39%), Gaps = 42/443 (9%)
Query: 1083 DEGEYSC--ILRDE----SCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL 1136
DEG Y C L D S TA+V V P +++ ++ G+ + E+ G+ +
Sbjct: 111 DEGLYQCEASLGDSGSIISRTAKVAVAG-PLRFLSQTESVTAFMGDTVLLKCEVI-GEPM 168
Query: 1137 --VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA------I 1188
+ W K+ ++ + L+I D G Y C N + +
Sbjct: 169 PTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEV 228
Query: 1189 LTVEEPSIN---FTLRLPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIE-DTEKFT 1243
+ +P ++ + L+ P ++ DA L + TW + + VI+ ++K++
Sbjct: 229 RILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYS 288
Query: 1244 LISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRG 1302
L+ L+I T+DD YTCV+ E+ V PP +++
Sbjct: 289 LLGG---SNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYES 345
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
D+ P P W+ N ++ + + S +L I V +D G Y+
Sbjct: 346 MDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGS---NLRILGVVKSDEGFYQCVA 402
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNI---------LEIDSSSINICWDEPENTGNSTII 1413
EN G+A + I+ KP+ P + + + S + + W P +
Sbjct: 403 ENEAGNAQTSAQL-IVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQT 461
Query: 1414 YYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
+ V +E D E ++ Q ++ NLK + Y FR A NE E+++ K
Sbjct: 462 FTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNE---WGPGESSQPIK 518
Query: 1473 VIKETKIQSPTVEKPLKNITTEP 1495
V + ++Q P + L+ ++T P
Sbjct: 519 VATQPELQVPGPVENLQAVSTSP 541
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/94 (31%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+ + + ++FEC V G P P + W + ++ PS FQ+ + L
Sbjct: 331 PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV----GGSNLR 386
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
I V D G + CVA+N AG A ++ +LIV P
Sbjct: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP 420
Score = 51.6 bits (118), Expect = 3e-05
Identities = 32/124 (25%), Positives = 48/124 (38%), Gaps = 7/124 (5%)
Query: 596 TELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLEC 655
+ L++ D T A++ +PP F P Y E DI EC
Sbjct: 293 SNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFEC 352
Query: 656 RLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNR 715
+ P P + W+ G+ ++P + + S+ L+I V K EG Y VA N
Sbjct: 353 TVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSN-------LRILGVVKSDEGFYQCVAENE 405
Query: 716 EGEA 719
G A
Sbjct: 406 AGNA 409
Score = 44.8 bits (101), Expect = 0.003
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 3/81 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G EC V GYP P TW R +I+ N L+I V +D+G +T
Sbjct: 253 EGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSN---LLISNVTDDDSGMYT 309
Query: 583 CVAKNAAGFASSTTELIVEAP 603
CV S++ EL V P
Sbjct: 310 CVVTYKNENISASAELTVLVP 330
Score = 44.4 bits (100), Expect = 0.005
Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 7/118 (5%)
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGG---LELTKYAIE 1704
S+T ++ T + + + VI RE +V + W+PPL+ G + Y ++
Sbjct: 928 SSTWSMTAHATTYEAAPTSAPKDFTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLD 987
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT 1762
K+ P ++ WI + + D T+ I LN + Y FR+ A+N G S+PI+ +T
Sbjct: 988 KNIPIDD-WI-METISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPL--SDPILFRT 1041
>AB211400-1|BAE79816.1| 1912|Homo sapiens protein tyrosine phosphatase
receptor type D protein.
Length = 1912
Score = 108 bits (259), Expect = 2e-22
Identities = 220/1036 (21%), Positives = 393/1036 (37%), Gaps = 111/1036 (10%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID- 1157
T E PP +Q G A+F + T GD + W K G ++ + D
Sbjct: 18 TDAETPPRFTRTPVDQTGVSGGVASFICQAT-GDPRPKIVWNKKGKKVSNQRFEVIEFDD 76
Query: 1158 GKKQKLKIYDCDLD-DAGEYSCEVGN-----SKCTAILTVEEPSI--NF-TLRL-PEFIL 1207
G L+I D Y C N S T + + E I F T+ + P+ +
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 1208 VP-ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT---------LIIRK 1257
V T L + ++TW+K ++ + I ++ + L I +
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQ 196
Query: 1258 CTEDDQCEYTCVLLDAKST-----TKLKV----EVVEFPPKIVDYEREYRIKRGSDVTLL 1308
E DQ +Y CV ++ T L V EV PP+ + I G V +
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNIT 256
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P +W++ ++ + P D ++ + + Y + G
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLT------PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGV 310
Query: 1369 ADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTE- 1426
+ +T+ P PPG P + E ++SI + WD +GN + YY+++++ ++ E
Sbjct: 311 IEAIAQITVKPLPKPPGTPVVTESTATSITLTWD----SGNPEPVSYYIIQHKPKNSEEL 366
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT--- 1483
+ + + T+ S+ L S Y FR AVN + SE V+ +T Q+P+
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE-----PVLTQTSEQAPSSAP 421
Query: 1484 --VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKK--LKTAKATYENRXXXXXXX 1539
V+ + + TT + E G + +V + D + K +
Sbjct: 422 RDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN 481
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGI 1599
K +AF G+ S IQ + + + K + E T+++
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSS--DIQVITQTGVPGQPLNFKAEPESE---TSILLSW 536
Query: 1600 PPPEVIWYKNGNKLEND----KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT--AGT 1653
PP N + D +E IT + TS R++ LK + + + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1654 SSVEVTLK-VYDKPSKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPD-- 1709
S+ E++ + + KPS P + S S+ + W+ PP++ +T+Y+I+ D
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
+++ ++ + D Y +++L + EY V A VG ES ++I+T DVPS
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPESLSVLIRTNEDVPSG 713
Query: 1770 XXXXXXXXXIDNESVYITW---FPSEKNG---GSPIIDYKVE------------IKQEGK 1811
+++ SV ++W P++++G G + ++E +
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 1812 KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
+W+ I L T+Y + A G S K+ + T P +PR
Sbjct: 774 QWEFDDTTEHDMI-ISGLQPETSYSLTVTAYTTKGDGA--RSKPKL-VSTTGAVPGKPR- 828
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE--HCIEN 1929
V++ + + ++W P G P+ Y ++F K + T+ S E +
Sbjct: 829 LVINHTQMNTALIQWHPPVDTFG-PLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATD 884
Query: 1930 IKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGT 1989
I + +FR+SA N VG E + VP+ L S V SW
Sbjct: 885 IHKGASYVFRLSARNKVGFG---EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQP 941
Query: 1990 PEW-DGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P + + Y + RD+ + ME V +T + L + TY +++ A
Sbjct: 942 PVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTGLKPDTTYDVKVRAHTSK 1000
Query: 2048 GLSEPLESDEPFKVIP 2063
G P F+ +P
Sbjct: 1001 G-PGPYSPSVQFRTLP 1015
Score = 78.2 bits (184), Expect = 3e-13
Identities = 81/307 (26%), Positives = 131/307 (42%), Gaps = 26/307 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F++ P Q G C+ P P I W KG++ V ++ V IE D
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEV-IEFD-DGSG 79
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
SVL+I ++ E Y VA N GE S+ L + ++ P P + + +V +
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 749 GESVILSAQVVGNPRPTITWCK---------NNKPVKALPTKSDGDT--HSITILKPKKV 797
+ + GNP P ITW K NN +K L ++S G T ++ +
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 798 KDEGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D+G Y A NS G ++ A + V E E PP F + G++ +
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+P+P + W E ++P + + G N+ L + +V S +Y CVA ++ G
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMP---IGRNV-LELNDVR---QSANYTCVAMSTLGVIE 312
Query: 917 HGARVTI 923
A++T+
Sbjct: 313 AIAQITV 319
Score = 73.7 bits (173), Expect = 6e-12
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 19/230 (8%)
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+IT+ PP P VV+EST+ S+TL W +S P++ YII+ K + K
Sbjct: 316 QITVKPLPKPPGTP---VVTESTATSITLTW---DSGNPEPVSYYIIQHKPKNSEELYKE 369
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ G + + + + + FR+ A N +G P+E + + A PS ++
Sbjct: 370 ID-GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA--PSSAPRDVQA 426
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTM--WMEVGKVDVNTLKFNIRDLS 2032
RM+ S ++ W PE G + GY + D T+ + WM+ D I +L
Sbjct: 427 RMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQIT--TIGNLV 483
Query: 2033 ENHTYMIRIYARNEIGLSEPLESDEPFKV---IPGEGSHADEEPGEQTEV 2079
TY +++ A IG PL SD +PG+ + EP +T +
Sbjct: 484 PQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Score = 65.7 bits (153), Expect = 2e-09
Identities = 76/311 (24%), Positives = 121/311 (38%), Gaps = 39/311 (12%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV-FPEDAGTFT 582
G F CQ G PRP+I W ++ + + + +DD + + L I+ + P D +
Sbjct: 38 GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYE 97
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N G S +T L V I G PT P+
Sbjct: 98 CVASNNVGEISVSTRLTV----------------------LREDQIPRGF-PTIDMGPQL 134
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC------SVLK 696
+ V+ + C P+P+I W FK V N + I+ L+
Sbjct: 135 KVVERTRTATMLCAASGNPDPEITW-FKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQ 193
Query: 697 ITNVKKFQEGTYTVVAVNREG-EASLP---IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
I ++ +G Y VA N G S P V +++ + PP+ P + + G SV
Sbjct: 194 IEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV 253
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ VG+P P + W + + T D +L+ V+ YT A ++ G
Sbjct: 254 NITCVAVGSPMPYVKWMLGAEDL----TPEDDMPIGRNVLELNDVRQSANYTCVAMSTLG 309
Query: 813 IAETSAVITVE 823
+ E A ITV+
Sbjct: 310 VIEAIAQITVK 320
Score = 52.8 bits (121), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 54/435 (12%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQD---FQMYYDDDNVAT-----LVIREVFPED 577
T C G P P+ITWF+ + S + + + T L I + D
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 578 AGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFS 637
G + CVA N+AG S AP + + E+ + +PP FS
Sbjct: 202 QGKYECVATNSAGTRYS-------APANLYVRELRE---------------VRRVPPRFS 239
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
P + G + + C V P P + W+ E++ P E DM + +VL++
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTP--------EDDMPIGRNVLEL 291
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILS 755
+V+ Q YT VA++ G + +K K P P V E + I +S
Sbjct: 292 NDVR--QSANYTCVAMSTLGVIEAIAQITVKPLPKPPGTPVVTESTATSITLTWDS---- 345
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
GNP P + +KP + + D + T + Y + I
Sbjct: 346 ----GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 816 TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
V T E A P R + + TI + + P I YR + P
Sbjct: 402 GPPSEPVLTQTSEQA--PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDP 459
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDY--KCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ + + IT + + + Y K +A S G + + + + +
Sbjct: 460 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 934 LQKSYETEEGKTVIL 948
L E E +++L
Sbjct: 520 LNFKAEPESETSILL 534
Score = 51.6 bits (118), Expect = 3e-05
Identities = 65/275 (23%), Positives = 107/275 (38%), Gaps = 22/275 (8%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP-VIMREISRESVTIEWKPP 1690
I L+ S T+ A T G + V + P P +++ + I+W PP
Sbjct: 787 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPP 846
Query: 1691 LDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS 1750
+D G L Y ++ D + + + + +++ Y+FR+ A+N VGF
Sbjct: 847 VDTFG-PLQGYRLKFGRKDMEP-LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904
Query: 1751 EALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKV--- 1804
E + E I +VP+ + SV ++W P +E+NG I Y +
Sbjct: 905 EEMVKE---ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYR 959
Query: 1805 EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLT 1864
+I + + L +TTY ++ A G PY+ + +TL
Sbjct: 960 DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQF---RTL- 1014
Query: 1865 PPSQ--PRNFVVSESTSRSVTLKWTEPES-NGGSP 1896
P Q +NF V SV L W PE+ N P
Sbjct: 1015 PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMP 1049
>L38929-1|AAC41749.1| 1912|Homo sapiens protein tyrosine phosphatase
delta protein.
Length = 1912
Score = 107 bits (258), Expect = 3e-22
Identities = 220/1036 (21%), Positives = 393/1036 (37%), Gaps = 111/1036 (10%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID- 1157
T E PP +Q G A+F + T GD + W K G ++ + D
Sbjct: 18 TDAETPPRFTRTPVDQTGVSGGVASFICQAT-GDPRPKIVWNKKGKKVSNQRFEVIEFDD 76
Query: 1158 GKKQKLKIYDCDLD-DAGEYSCEVGN-----SKCTAILTVEEPSI--NF-TLRL-PEFIL 1207
G L+I D Y C N S T + + E I F T+ + P+ +
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 1208 VP-ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT---------LIIRK 1257
V T L + ++TW+K ++ + I ++ + L I +
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQ 196
Query: 1258 CTEDDQCEYTCVLLDAKST-----TKLKV----EVVEFPPKIVDYEREYRIKRGSDVTLL 1308
E DQ +Y CV ++ T L V EV PP+ + I G V +
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNIT 256
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P +W++ ++ + P D ++ + + Y + G
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLT------PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGV 310
Query: 1369 ADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTE- 1426
+ +T+ P PPG P + E ++SI + WD +GN + YY+++++ ++ E
Sbjct: 311 IEAIAQITVKALPKPPGTPVVTESTATSITLTWD----SGNPEPVSYYIIQHKPKNSEEL 366
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT--- 1483
+ + + T+ S+ L S Y FR AVN + SE V+ +T Q+P+
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE-----PVLTQTSEQAPSSAP 421
Query: 1484 --VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKK--LKTAKATYENRXXXXXXX 1539
V+ + + TT + E G + +V + D + K +
Sbjct: 422 RDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN 481
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGI 1599
K +AF G+ S IQ + + + K + E T+++
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSS--DIQVITQTGVPGQPLNFKAEPESE---TSILLSW 536
Query: 1600 PPPEVIWYKNGNKLEND----KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT--AGT 1653
PP N + D +E IT + TS R++ LK + + + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1654 SSVEVTLK-VYDKPSKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPD-- 1709
S+ E++ + + KPS P + S S+ + W+ PP++ +T+Y+I+ D
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
+++ ++ + D Y +++L + EY V A VG ES ++I+T DVPS
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPESLSVLIRTNEDVPSG 713
Query: 1770 XXXXXXXXXIDNESVYITW---FPSEKNG---GSPIIDYKVE------------IKQEGK 1811
+++ SV ++W P++++G G + ++E +
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 1812 KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
+W+ I L T+Y + A G S K+ + T P +PR
Sbjct: 774 QWEFDDTTEHDMI-ISGLQPETSYSLTVTAYTTKGDGA--RSKPKL-VSTTGAVPGKPR- 828
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE--HCIEN 1929
V++ + + ++W P G P+ Y ++F K + T+ S E +
Sbjct: 829 LVINHTQMNTALIQWHPPVDTFG-PLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATD 884
Query: 1930 IKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGT 1989
I + +FR+SA N VG E + VP+ L S V SW
Sbjct: 885 IHKGASYVFRLSARNKVGFG---EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQP 941
Query: 1990 PEW-DGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P + + Y + RD+ + ME V +T + L + TY +++ A
Sbjct: 942 PVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTGLKPDTTYDVKVRAHTSK 1000
Query: 2048 GLSEPLESDEPFKVIP 2063
G P F+ +P
Sbjct: 1001 G-PGPYSPSVQFRTLP 1015
Score = 78.2 bits (184), Expect = 3e-13
Identities = 81/307 (26%), Positives = 131/307 (42%), Gaps = 26/307 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F++ P Q G C+ P P I W KG++ V ++ V IE D
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEV-IEFD-DGSG 79
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
SVL+I ++ E Y VA N GE S+ L + ++ P P + + +V +
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 749 GESVILSAQVVGNPRPTITWCK---------NNKPVKALPTKSDGDT--HSITILKPKKV 797
+ + GNP P ITW K NN +K L ++S G T ++ +
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 798 KDEGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D+G Y A NS G ++ A + V E E PP F + G++ +
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+P+P + W E ++P + + G N+ L + +V S +Y CVA ++ G
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMP---IGRNV-LELNDVR---QSANYTCVAMSTLGVIE 312
Query: 917 HGARVTI 923
A++T+
Sbjct: 313 AIAQITV 319
Score = 73.7 bits (173), Expect = 6e-12
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 19/230 (8%)
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+IT+ PP P VV+EST+ S+TL W +S P++ YII+ K + K
Sbjct: 316 QITVKALPKPPGTP---VVTESTATSITLTW---DSGNPEPVSYYIIQHKPKNSEELYKE 369
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ G + + + + + FR+ A N +G P+E + + A PS ++
Sbjct: 370 ID-GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA--PSSAPRDVQA 426
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTM--WMEVGKVDVNTLKFNIRDLS 2032
RM+ S ++ W PE G + GY + D T+ + WM+ D I +L
Sbjct: 427 RMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQIT--TIGNLV 483
Query: 2033 ENHTYMIRIYARNEIGLSEPLESDEPFKV---IPGEGSHADEEPGEQTEV 2079
TY +++ A IG PL SD +PG+ + EP +T +
Sbjct: 484 PQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Score = 65.7 bits (153), Expect = 2e-09
Identities = 76/311 (24%), Positives = 121/311 (38%), Gaps = 39/311 (12%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV-FPEDAGTFT 582
G F CQ G PRP+I W ++ + + + +DD + + L I+ + P D +
Sbjct: 38 GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYE 97
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N G S +T L V I G PT P+
Sbjct: 98 CVASNNVGEISVSTRLTV----------------------LREDQIPRGF-PTIDMGPQL 134
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC------SVLK 696
+ V+ + C P+P+I W FK V N + I+ L+
Sbjct: 135 KVVERTRTATMLCAASGNPDPEITW-FKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQ 193
Query: 697 ITNVKKFQEGTYTVVAVNREG-EASLP---IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
I ++ +G Y VA N G S P V +++ + PP+ P + + G SV
Sbjct: 194 IEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV 253
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ VG+P P + W + + T D +L+ V+ YT A ++ G
Sbjct: 254 NITCVAVGSPMPYVKWMLGAEDL----TPEDDMPIGRNVLELNDVRQSANYTCVAMSTLG 309
Query: 813 IAETSAVITVE 823
+ E A ITV+
Sbjct: 310 VIEAIAQITVK 320
Score = 53.2 bits (122), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 54/435 (12%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQD---FQMYYDDDNVAT-----LVIREVFPED 577
T C G P P+ITWF+ + S + + + T L I + D
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 578 AGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFS 637
G + CVA N+AG S AP + + E+ + +PP FS
Sbjct: 202 QGKYECVATNSAGTRYS-------APANLYVRELRE---------------VRRVPPRFS 239
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
P + G + + C V P P + W+ E++ P E DM + +VL++
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTP--------EDDMPIGRNVLEL 291
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILS 755
+V+ Q YT VA++ G + +K K P P V E + I +S
Sbjct: 292 NDVR--QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS---- 345
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
GNP P + +KP + + D + T + Y + I
Sbjct: 346 ----GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 816 TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
V T E A P R + + TI + + P I YR + P
Sbjct: 402 GPPSEPVLTQTSEQA--PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDP 459
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDY--KCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ + + IT + + + Y K +A S G + + + + +
Sbjct: 460 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 934 LQKSYETEEGKTVIL 948
L E E +++L
Sbjct: 520 LNFKAEPESETSILL 534
Score = 51.6 bits (118), Expect = 3e-05
Identities = 65/275 (23%), Positives = 107/275 (38%), Gaps = 22/275 (8%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP-VIMREISRESVTIEWKPP 1690
I L+ S T+ A T G + V + P P +++ + I+W PP
Sbjct: 787 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPP 846
Query: 1691 LDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS 1750
+D G L Y ++ D + + + + +++ Y+FR+ A+N VGF
Sbjct: 847 VDTFG-PLQGYRLKFGRKDMEP-LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904
Query: 1751 EALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKV--- 1804
E + E I +VP+ + SV ++W P +E+NG I Y +
Sbjct: 905 EEMVKE---ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYR 959
Query: 1805 EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLT 1864
+I + + L +TTY ++ A G PY+ + +TL
Sbjct: 960 DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQF---RTL- 1014
Query: 1865 PPSQ--PRNFVVSESTSRSVTLKWTEPES-NGGSP 1896
P Q +NF V SV L W PE+ N P
Sbjct: 1015 PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMP 1049
>AL590397-1|CAH73128.2| 1912|Homo sapiens protein tyrosine
phosphatase, receptor type, D protein.
Length = 1912
Score = 107 bits (258), Expect = 3e-22
Identities = 220/1036 (21%), Positives = 393/1036 (37%), Gaps = 111/1036 (10%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID- 1157
T E PP +Q G A+F + T GD + W K G ++ + D
Sbjct: 18 TDAETPPRFTRTPVDQTGVSGGVASFICQAT-GDPRPKIVWNKKGKKVSNQRFEVIEFDD 76
Query: 1158 GKKQKLKIYDCDLD-DAGEYSCEVGN-----SKCTAILTVEEPSI--NF-TLRL-PEFIL 1207
G L+I D Y C N S T + + E I F T+ + P+ +
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 1208 VP-ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT---------LIIRK 1257
V T L + ++TW+K ++ + I ++ + L I +
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQ 196
Query: 1258 CTEDDQCEYTCVLLDAKST-----TKLKV----EVVEFPPKIVDYEREYRIKRGSDVTLL 1308
E DQ +Y CV ++ T L V EV PP+ + I G V +
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNIT 256
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P +W++ ++ + P D ++ + + Y + G
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLT------PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGV 310
Query: 1369 ADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTE- 1426
+ +T+ P PPG P + E ++SI + WD +GN + YY+++++ ++ E
Sbjct: 311 IEAIAQITVKALPKPPGTPVVTESTATSITLTWD----SGNPEPVSYYIIQHKPKNSEEL 366
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT--- 1483
+ + + T+ S+ L S Y FR AVN + SE V+ +T Q+P+
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE-----PVLTQTSEQAPSSAP 421
Query: 1484 --VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKK--LKTAKATYENRXXXXXXX 1539
V+ + + TT + E G + +V + D + K +
Sbjct: 422 RDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN 481
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGI 1599
K +AF G+ S IQ + + + K + E T+++
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSS--DIQVITQTGVPGQPLNFKAEPESE---TSILLSW 536
Query: 1600 PPPEVIWYKNGNKLEND----KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT--AGT 1653
PP N + D +E IT + TS R++ LK + + + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1654 SSVEVTLK-VYDKPSKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPD-- 1709
S+ E++ + + KPS P + S S+ + W+ PP++ +T+Y+I+ D
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
+++ ++ + D Y +++L + EY V A VG ES ++I+T DVPS
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPESLSVLIRTNEDVPSG 713
Query: 1770 XXXXXXXXXIDNESVYITW---FPSEKNG---GSPIIDYKVE------------IKQEGK 1811
+++ SV ++W P++++G G + ++E +
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 1812 KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
+W+ I L T+Y + A G S K+ + T P +PR
Sbjct: 774 QWEFDDTTEHDMI-ISGLQPETSYSLTVTAYTTKGDGA--RSKPKL-VSTTGAVPGKPR- 828
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE--HCIEN 1929
V++ + + ++W P G P+ Y ++F K + T+ S E +
Sbjct: 829 LVINHTQMNTALIQWHPPVDTFG-PLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATD 884
Query: 1930 IKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGT 1989
I + +FR+SA N VG E + VP+ L S V SW
Sbjct: 885 IHKGASYVFRLSARNKVGFG---EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQP 941
Query: 1990 PEW-DGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P + + Y + RD+ + ME V +T + L + TY +++ A
Sbjct: 942 PVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTGLKPDTTYDVKVRAHTSK 1000
Query: 2048 GLSEPLESDEPFKVIP 2063
G P F+ +P
Sbjct: 1001 G-PGPYSPSVQFRTLP 1015
Score = 78.2 bits (184), Expect = 3e-13
Identities = 81/307 (26%), Positives = 131/307 (42%), Gaps = 26/307 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F++ P Q G C+ P P I W KG++ V ++ V IE D
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEV-IEFD-DGSG 79
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
SVL+I ++ E Y VA N GE S+ L + ++ P P + + +V +
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 749 GESVILSAQVVGNPRPTITWCK---------NNKPVKALPTKSDGDT--HSITILKPKKV 797
+ + GNP P ITW K NN +K L ++S G T ++ +
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 798 KDEGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D+G Y A NS G ++ A + V E E PP F + G++ +
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+P+P + W E ++P + + G N+ L + +V S +Y CVA ++ G
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMP---IGRNV-LELNDVR---QSANYTCVAMSTLGVIE 312
Query: 917 HGARVTI 923
A++T+
Sbjct: 313 AIAQITV 319
Score = 73.7 bits (173), Expect = 6e-12
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 19/230 (8%)
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+IT+ PP P VV+EST+ S+TL W +S P++ YII+ K + K
Sbjct: 316 QITVKALPKPPGTP---VVTESTATSITLTW---DSGNPEPVSYYIIQHKPKNSEELYKE 369
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ G + + + + + FR+ A N +G P+E + + A PS ++
Sbjct: 370 ID-GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA--PSSAPRDVQA 426
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTM--WMEVGKVDVNTLKFNIRDLS 2032
RM+ S ++ W PE G + GY + D T+ + WM+ D I +L
Sbjct: 427 RMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQIT--TIGNLV 483
Query: 2033 ENHTYMIRIYARNEIGLSEPLESDEPFKV---IPGEGSHADEEPGEQTEV 2079
TY +++ A IG PL SD +PG+ + EP +T +
Sbjct: 484 PQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Score = 65.7 bits (153), Expect = 2e-09
Identities = 76/311 (24%), Positives = 121/311 (38%), Gaps = 39/311 (12%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV-FPEDAGTFT 582
G F CQ G PRP+I W ++ + + + +DD + + L I+ + P D +
Sbjct: 38 GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYE 97
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N G S +T L V I G PT P+
Sbjct: 98 CVASNNVGEISVSTRLTV----------------------LREDQIPRGF-PTIDMGPQL 134
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC------SVLK 696
+ V+ + C P+P+I W FK V N + I+ L+
Sbjct: 135 KVVERTRTATMLCAASGNPDPEITW-FKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQ 193
Query: 697 ITNVKKFQEGTYTVVAVNREG-EASLP---IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
I ++ +G Y VA N G S P V +++ + PP+ P + + G SV
Sbjct: 194 IEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV 253
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ VG+P P + W + + T D +L+ V+ YT A ++ G
Sbjct: 254 NITCVAVGSPMPYVKWMLGAEDL----TPEDDMPIGRNVLELNDVRQSANYTCVAMSTLG 309
Query: 813 IAETSAVITVE 823
+ E A ITV+
Sbjct: 310 VIEAIAQITVK 320
Score = 53.2 bits (122), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 54/435 (12%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQD---FQMYYDDDNVAT-----LVIREVFPED 577
T C G P P+ITWF+ + S + + + T L I + D
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 578 AGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFS 637
G + CVA N+AG S AP + + E+ + +PP FS
Sbjct: 202 QGKYECVATNSAGTRYS-------APANLYVRELRE---------------VRRVPPRFS 239
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
P + G + + C V P P + W+ E++ P E DM + +VL++
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTP--------EDDMPIGRNVLEL 291
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILS 755
+V+ Q YT VA++ G + +K K P P V E + I +S
Sbjct: 292 NDVR--QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS---- 345
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
GNP P + +KP + + D + T + Y + I
Sbjct: 346 ----GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 816 TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
V T E A P R + + TI + + P I YR + P
Sbjct: 402 GPPSEPVLTQTSEQA--PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDP 459
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDY--KCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ + + IT + + + Y K +A S G + + + + +
Sbjct: 460 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 934 LQKSYETEEGKTVIL 948
L E E +++L
Sbjct: 520 LNFKAEPESETSILL 534
Score = 51.6 bits (118), Expect = 3e-05
Identities = 65/275 (23%), Positives = 107/275 (38%), Gaps = 22/275 (8%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP-VIMREISRESVTIEWKPP 1690
I L+ S T+ A T G + V + P P +++ + I+W PP
Sbjct: 787 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPP 846
Query: 1691 LDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS 1750
+D G L Y ++ D + + + + +++ Y+FR+ A+N VGF
Sbjct: 847 VDTFG-PLQGYRLKFGRKDMEP-LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904
Query: 1751 EALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKV--- 1804
E + E I +VP+ + SV ++W P +E+NG I Y +
Sbjct: 905 EEMVKE---ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYR 959
Query: 1805 EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLT 1864
+I + + L +TTY ++ A G PY+ + +TL
Sbjct: 960 DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQF---RTL- 1014
Query: 1865 PPSQ--PRNFVVSESTSRSVTLKWTEPES-NGGSP 1896
P Q +NF V SV L W PE+ N P
Sbjct: 1015 PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMP 1049
>AL583805-2|CAH70443.2| 1912|Homo sapiens protein tyrosine
phosphatase, receptor type, D protein.
Length = 1912
Score = 107 bits (258), Expect = 3e-22
Identities = 220/1036 (21%), Positives = 393/1036 (37%), Gaps = 111/1036 (10%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID- 1157
T E PP +Q G A+F + T GD + W K G ++ + D
Sbjct: 18 TDAETPPRFTRTPVDQTGVSGGVASFICQAT-GDPRPKIVWNKKGKKVSNQRFEVIEFDD 76
Query: 1158 GKKQKLKIYDCDLD-DAGEYSCEVGN-----SKCTAILTVEEPSI--NF-TLRL-PEFIL 1207
G L+I D Y C N S T + + E I F T+ + P+ +
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 1208 VP-ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT---------LIIRK 1257
V T L + ++TW+K ++ + I ++ + L I +
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQ 196
Query: 1258 CTEDDQCEYTCVLLDAKST-----TKLKV----EVVEFPPKIVDYEREYRIKRGSDVTLL 1308
E DQ +Y CV ++ T L V EV PP+ + I G V +
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNIT 256
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P +W++ ++ + P D ++ + + Y + G
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLT------PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGV 310
Query: 1369 ADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTE- 1426
+ +T+ P PPG P + E ++SI + WD +GN + YY+++++ ++ E
Sbjct: 311 IEAIAQITVKALPKPPGTPVVTESTATSITLTWD----SGNPEPVSYYIIQHKPKNSEEL 366
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT--- 1483
+ + + T+ S+ L S Y FR AVN + SE V+ +T Q+P+
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE-----PVLTQTSEQAPSSAP 421
Query: 1484 --VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKK--LKTAKATYENRXXXXXXX 1539
V+ + + TT + E G + +V + D + K +
Sbjct: 422 RDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN 481
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGI 1599
K +AF G+ S IQ + + + K + E T+++
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSS--DIQVITQTGVPGQPLNFKAEPESE---TSILLSW 536
Query: 1600 PPPEVIWYKNGNKLEND----KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT--AGT 1653
PP N + D +E IT + TS R++ LK + + + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1654 SSVEVTLK-VYDKPSKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPD-- 1709
S+ E++ + + KPS P + S S+ + W+ PP++ +T+Y+I+ D
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
+++ ++ + D Y +++L + EY V A VG ES ++I+T DVPS
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPESLSVLIRTNEDVPSG 713
Query: 1770 XXXXXXXXXIDNESVYITW---FPSEKNG---GSPIIDYKVE------------IKQEGK 1811
+++ SV ++W P++++G G + ++E +
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 1812 KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
+W+ I L T+Y + A G S K+ + T P +PR
Sbjct: 774 QWEFDDTTEHDMI-ISGLQPETSYSLTVTAYTTKGDGA--RSKPKL-VSTTGAVPGKPR- 828
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE--HCIEN 1929
V++ + + ++W P G P+ Y ++F K + T+ S E +
Sbjct: 829 LVINHTQMNTALIQWHPPVDTFG-PLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATD 884
Query: 1930 IKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGT 1989
I + +FR+SA N VG E + VP+ L S V SW
Sbjct: 885 IHKGASYVFRLSARNKVGFG---EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQP 941
Query: 1990 PEW-DGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P + + Y + RD+ + ME V +T + L + TY +++ A
Sbjct: 942 PVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTGLKPDTTYDVKVRAHTSK 1000
Query: 2048 GLSEPLESDEPFKVIP 2063
G P F+ +P
Sbjct: 1001 G-PGPYSPSVQFRTLP 1015
Score = 78.2 bits (184), Expect = 3e-13
Identities = 81/307 (26%), Positives = 131/307 (42%), Gaps = 26/307 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F++ P Q G C+ P P I W KG++ V ++ V IE D
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEV-IEFD-DGSG 79
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
SVL+I ++ E Y VA N GE S+ L + ++ P P + + +V +
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 749 GESVILSAQVVGNPRPTITWCK---------NNKPVKALPTKSDGDT--HSITILKPKKV 797
+ + GNP P ITW K NN +K L ++S G T ++ +
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 798 KDEGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D+G Y A NS G ++ A + V E E PP F + G++ +
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+P+P + W E ++P + + G N+ L + +V S +Y CVA ++ G
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMP---IGRNV-LELNDVR---QSANYTCVAMSTLGVIE 312
Query: 917 HGARVTI 923
A++T+
Sbjct: 313 AIAQITV 319
Score = 73.7 bits (173), Expect = 6e-12
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 19/230 (8%)
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+IT+ PP P VV+EST+ S+TL W +S P++ YII+ K + K
Sbjct: 316 QITVKALPKPPGTP---VVTESTATSITLTW---DSGNPEPVSYYIIQHKPKNSEELYKE 369
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ G + + + + + FR+ A N +G P+E + + A PS ++
Sbjct: 370 ID-GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA--PSSAPRDVQA 426
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTM--WMEVGKVDVNTLKFNIRDLS 2032
RM+ S ++ W PE G + GY + D T+ + WM+ D I +L
Sbjct: 427 RMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQIT--TIGNLV 483
Query: 2033 ENHTYMIRIYARNEIGLSEPLESDEPFKV---IPGEGSHADEEPGEQTEV 2079
TY +++ A IG PL SD +PG+ + EP +T +
Sbjct: 484 PQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Score = 65.7 bits (153), Expect = 2e-09
Identities = 76/311 (24%), Positives = 121/311 (38%), Gaps = 39/311 (12%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV-FPEDAGTFT 582
G F CQ G PRP+I W ++ + + + +DD + + L I+ + P D +
Sbjct: 38 GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYE 97
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N G S +T L V I G PT P+
Sbjct: 98 CVASNNVGEISVSTRLTV----------------------LREDQIPRGF-PTIDMGPQL 134
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC------SVLK 696
+ V+ + C P+P+I W FK V N + I+ L+
Sbjct: 135 KVVERTRTATMLCAASGNPDPEITW-FKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQ 193
Query: 697 ITNVKKFQEGTYTVVAVNREG-EASLP---IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
I ++ +G Y VA N G S P V +++ + PP+ P + + G SV
Sbjct: 194 IEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV 253
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ VG+P P + W + + T D +L+ V+ YT A ++ G
Sbjct: 254 NITCVAVGSPMPYVKWMLGAEDL----TPEDDMPIGRNVLELNDVRQSANYTCVAMSTLG 309
Query: 813 IAETSAVITVE 823
+ E A ITV+
Sbjct: 310 VIEAIAQITVK 320
Score = 53.2 bits (122), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 54/435 (12%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQD---FQMYYDDDNVAT-----LVIREVFPED 577
T C G P P+ITWF+ + S + + + T L I + D
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 578 AGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFS 637
G + CVA N+AG S AP + + E+ + +PP FS
Sbjct: 202 QGKYECVATNSAGTRYS-------APANLYVRELRE---------------VRRVPPRFS 239
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
P + G + + C V P P + W+ E++ P E DM + +VL++
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTP--------EDDMPIGRNVLEL 291
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILS 755
+V+ Q YT VA++ G + +K K P P V E + I +S
Sbjct: 292 NDVR--QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS---- 345
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
GNP P + +KP + + D + T + Y + I
Sbjct: 346 ----GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 816 TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
V T E A P R + + TI + + P I YR + P
Sbjct: 402 GPPSEPVLTQTSEQA--PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDP 459
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDY--KCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ + + IT + + + Y K +A S G + + + + +
Sbjct: 460 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 934 LQKSYETEEGKTVIL 948
L E E +++L
Sbjct: 520 LNFKAEPESETSILL 534
Score = 51.6 bits (118), Expect = 3e-05
Identities = 65/275 (23%), Positives = 107/275 (38%), Gaps = 22/275 (8%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP-VIMREISRESVTIEWKPP 1690
I L+ S T+ A T G + V + P P +++ + I+W PP
Sbjct: 787 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPP 846
Query: 1691 LDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS 1750
+D G L Y ++ D + + + + +++ Y+FR+ A+N VGF
Sbjct: 847 VDTFG-PLQGYRLKFGRKDMEP-LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904
Query: 1751 EALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKV--- 1804
E + E I +VP+ + SV ++W P +E+NG I Y +
Sbjct: 905 EEMVKE---ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYR 959
Query: 1805 EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLT 1864
+I + + L +TTY ++ A G PY+ + +TL
Sbjct: 960 DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQF---RTL- 1014
Query: 1865 PPSQ--PRNFVVSESTSRSVTLKWTEPES-NGGSP 1896
P Q +NF V SV L W PE+ N P
Sbjct: 1015 PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMP 1049
>AL445926-1|CAH73847.2| 1912|Homo sapiens protein tyrosine
phosphatase, receptor type, D protein.
Length = 1912
Score = 107 bits (258), Expect = 3e-22
Identities = 220/1036 (21%), Positives = 393/1036 (37%), Gaps = 111/1036 (10%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID- 1157
T E PP +Q G A+F + T GD + W K G ++ + D
Sbjct: 18 TDAETPPRFTRTPVDQTGVSGGVASFICQAT-GDPRPKIVWNKKGKKVSNQRFEVIEFDD 76
Query: 1158 GKKQKLKIYDCDLD-DAGEYSCEVGN-----SKCTAILTVEEPSI--NF-TLRL-PEFIL 1207
G L+I D Y C N S T + + E I F T+ + P+ +
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 1208 VP-ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT---------LIIRK 1257
V T L + ++TW+K ++ + I ++ + L I +
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQ 196
Query: 1258 CTEDDQCEYTCVLLDAKST-----TKLKV----EVVEFPPKIVDYEREYRIKRGSDVTLL 1308
E DQ +Y CV ++ T L V EV PP+ + I G V +
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNIT 256
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P +W++ ++ + P D ++ + + Y + G
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLT------PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGV 310
Query: 1369 ADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTE- 1426
+ +T+ P PPG P + E ++SI + WD +GN + YY+++++ ++ E
Sbjct: 311 IEAIAQITVKALPKPPGTPVVTESTATSITLTWD----SGNPEPVSYYIIQHKPKNSEEL 366
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT--- 1483
+ + + T+ S+ L S Y FR AVN + SE V+ +T Q+P+
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE-----PVLTQTSEQAPSSAP 421
Query: 1484 --VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKK--LKTAKATYENRXXXXXXX 1539
V+ + + TT + E G + +V + D + K +
Sbjct: 422 RDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN 481
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGI 1599
K +AF G+ S IQ + + + K + E T+++
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSS--DIQVITQTGVPGQPLNFKAEPESE---TSILLSW 536
Query: 1600 PPPEVIWYKNGNKLEND----KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT--AGT 1653
PP N + D +E IT + TS R++ LK + + + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1654 SSVEVTLK-VYDKPSKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPD-- 1709
S+ E++ + + KPS P + S S+ + W+ PP++ +T+Y+I+ D
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
+++ ++ + D Y +++L + EY V A VG ES ++I+T DVPS
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPESLSVLIRTNEDVPSG 713
Query: 1770 XXXXXXXXXIDNESVYITW---FPSEKNG---GSPIIDYKVE------------IKQEGK 1811
+++ SV ++W P++++G G + ++E +
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 1812 KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
+W+ I L T+Y + A G S K+ + T P +PR
Sbjct: 774 QWEFDDTTEHDMI-ISGLQPETSYSLTVTAYTTKGDGA--RSKPKL-VSTTGAVPGKPR- 828
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE--HCIEN 1929
V++ + + ++W P G P+ Y ++F K + T+ S E +
Sbjct: 829 LVINHTQMNTALIQWHPPVDTFG-PLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATD 884
Query: 1930 IKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGT 1989
I + +FR+SA N VG E + VP+ L S V SW
Sbjct: 885 IHKGASYVFRLSARNKVGFG---EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQP 941
Query: 1990 PEW-DGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P + + Y + RD+ + ME V +T + L + TY +++ A
Sbjct: 942 PVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTGLKPDTTYDVKVRAHTSK 1000
Query: 2048 GLSEPLESDEPFKVIP 2063
G P F+ +P
Sbjct: 1001 G-PGPYSPSVQFRTLP 1015
Score = 78.2 bits (184), Expect = 3e-13
Identities = 81/307 (26%), Positives = 131/307 (42%), Gaps = 26/307 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F++ P Q G C+ P P I W KG++ V ++ V IE D
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEV-IEFD-DGSG 79
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
SVL+I ++ E Y VA N GE S+ L + ++ P P + + +V +
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 749 GESVILSAQVVGNPRPTITWCK---------NNKPVKALPTKSDGDT--HSITILKPKKV 797
+ + GNP P ITW K NN +K L ++S G T ++ +
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 798 KDEGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D+G Y A NS G ++ A + V E E PP F + G++ +
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+P+P + W E ++P + + G N+ L + +V S +Y CVA ++ G
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMP---IGRNV-LELNDVR---QSANYTCVAMSTLGVIE 312
Query: 917 HGARVTI 923
A++T+
Sbjct: 313 AIAQITV 319
Score = 73.7 bits (173), Expect = 6e-12
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 19/230 (8%)
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+IT+ PP P VV+EST+ S+TL W +S P++ YII+ K + K
Sbjct: 316 QITVKALPKPPGTP---VVTESTATSITLTW---DSGNPEPVSYYIIQHKPKNSEELYKE 369
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ G + + + + + FR+ A N +G P+E + + A PS ++
Sbjct: 370 ID-GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA--PSSAPRDVQA 426
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTM--WMEVGKVDVNTLKFNIRDLS 2032
RM+ S ++ W PE G + GY + D T+ + WM+ D I +L
Sbjct: 427 RMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQIT--TIGNLV 483
Query: 2033 ENHTYMIRIYARNEIGLSEPLESDEPFKV---IPGEGSHADEEPGEQTEV 2079
TY +++ A IG PL SD +PG+ + EP +T +
Sbjct: 484 PQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Score = 65.7 bits (153), Expect = 2e-09
Identities = 76/311 (24%), Positives = 121/311 (38%), Gaps = 39/311 (12%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV-FPEDAGTFT 582
G F CQ G PRP+I W ++ + + + +DD + + L I+ + P D +
Sbjct: 38 GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYE 97
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N G S +T L V I G PT P+
Sbjct: 98 CVASNNVGEISVSTRLTV----------------------LREDQIPRGF-PTIDMGPQL 134
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC------SVLK 696
+ V+ + C P+P+I W FK V N + I+ L+
Sbjct: 135 KVVERTRTATMLCAASGNPDPEITW-FKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQ 193
Query: 697 ITNVKKFQEGTYTVVAVNREG-EASLP---IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
I ++ +G Y VA N G S P V +++ + PP+ P + + G SV
Sbjct: 194 IEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV 253
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ VG+P P + W + + T D +L+ V+ YT A ++ G
Sbjct: 254 NITCVAVGSPMPYVKWMLGAEDL----TPEDDMPIGRNVLELNDVRQSANYTCVAMSTLG 309
Query: 813 IAETSAVITVE 823
+ E A ITV+
Sbjct: 310 VIEAIAQITVK 320
Score = 53.2 bits (122), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 54/435 (12%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQD---FQMYYDDDNVAT-----LVIREVFPED 577
T C G P P+ITWF+ + S + + + T L I + D
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 578 AGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFS 637
G + CVA N+AG S AP + + E+ + +PP FS
Sbjct: 202 QGKYECVATNSAGTRYS-------APANLYVRELRE---------------VRRVPPRFS 239
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
P + G + + C V P P + W+ E++ P E DM + +VL++
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTP--------EDDMPIGRNVLEL 291
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILS 755
+V+ Q YT VA++ G + +K K P P V E + I +S
Sbjct: 292 NDVR--QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS---- 345
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
GNP P + +KP + + D + T + Y + I
Sbjct: 346 ----GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 816 TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
V T E A P R + + TI + + P I YR + P
Sbjct: 402 GPPSEPVLTQTSEQA--PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDP 459
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDY--KCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ + + IT + + + Y K +A S G + + + + +
Sbjct: 460 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 934 LQKSYETEEGKTVIL 948
L E E +++L
Sbjct: 520 LNFKAEPESETSILL 534
Score = 51.6 bits (118), Expect = 3e-05
Identities = 65/275 (23%), Positives = 107/275 (38%), Gaps = 22/275 (8%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP-VIMREISRESVTIEWKPP 1690
I L+ S T+ A T G + V + P P +++ + I+W PP
Sbjct: 787 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPP 846
Query: 1691 LDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS 1750
+D G L Y ++ D + + + + +++ Y+FR+ A+N VGF
Sbjct: 847 VDTFG-PLQGYRLKFGRKDMEP-LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904
Query: 1751 EALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKV--- 1804
E + E I +VP+ + SV ++W P +E+NG I Y +
Sbjct: 905 EEMVKE---ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYR 959
Query: 1805 EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLT 1864
+I + + L +TTY ++ A G PY+ + +TL
Sbjct: 960 DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQF---RTL- 1014
Query: 1865 PPSQ--PRNFVVSESTSRSVTLKWTEPES-NGGSP 1896
P Q +NF V SV L W PE+ N P
Sbjct: 1015 PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMP 1049
>AL356584-1|CAI16146.2| 1912|Homo sapiens protein tyrosine
phosphatase, receptor type, D protein.
Length = 1912
Score = 107 bits (258), Expect = 3e-22
Identities = 220/1036 (21%), Positives = 393/1036 (37%), Gaps = 111/1036 (10%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID- 1157
T E PP +Q G A+F + T GD + W K G ++ + D
Sbjct: 18 TDAETPPRFTRTPVDQTGVSGGVASFICQAT-GDPRPKIVWNKKGKKVSNQRFEVIEFDD 76
Query: 1158 GKKQKLKIYDCDLD-DAGEYSCEVGN-----SKCTAILTVEEPSI--NF-TLRL-PEFIL 1207
G L+I D Y C N S T + + E I F T+ + P+ +
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 1208 VP-ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT---------LIIRK 1257
V T L + ++TW+K ++ + I ++ + L I +
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQ 196
Query: 1258 CTEDDQCEYTCVLLDAKST-----TKLKV----EVVEFPPKIVDYEREYRIKRGSDVTLL 1308
E DQ +Y CV ++ T L V EV PP+ + I G V +
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNIT 256
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P +W++ ++ + P D ++ + + Y + G
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLT------PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGV 310
Query: 1369 ADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTE- 1426
+ +T+ P PPG P + E ++SI + WD +GN + YY+++++ ++ E
Sbjct: 311 IEAIAQITVKALPKPPGTPVVTESTATSITLTWD----SGNPEPVSYYIIQHKPKNSEEL 366
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT--- 1483
+ + + T+ S+ L S Y FR AVN + SE V+ +T Q+P+
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE-----PVLTQTSEQAPSSAP 421
Query: 1484 --VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKK--LKTAKATYENRXXXXXXX 1539
V+ + + TT + E G + +V + D + K +
Sbjct: 422 RDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN 481
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGI 1599
K +AF G+ S IQ + + + K + E T+++
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSS--DIQVITQTGVPGQPLNFKAEPESE---TSILLSW 536
Query: 1600 PPPEVIWYKNGNKLEND----KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT--AGT 1653
PP N + D +E IT + TS R++ LK + + + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1654 SSVEVTLK-VYDKPSKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPD-- 1709
S+ E++ + + KPS P + S S+ + W+ PP++ +T+Y+I+ D
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
+++ ++ + D Y +++L + EY V A VG ES ++I+T DVPS
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPESLSVLIRTNEDVPSG 713
Query: 1770 XXXXXXXXXIDNESVYITW---FPSEKNG---GSPIIDYKVE------------IKQEGK 1811
+++ SV ++W P++++G G + ++E +
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 1812 KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
+W+ I L T+Y + A G S K+ + T P +PR
Sbjct: 774 QWEFDDTTEHDMI-ISGLQPETSYSLTVTAYTTKGDGA--RSKPKL-VSTTGAVPGKPR- 828
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE--HCIEN 1929
V++ + + ++W P G P+ Y ++F K + T+ S E +
Sbjct: 829 LVINHTQMNTALIQWHPPVDTFG-PLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATD 884
Query: 1930 IKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGT 1989
I + +FR+SA N VG E + VP+ L S V SW
Sbjct: 885 IHKGASYVFRLSARNKVGFG---EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQP 941
Query: 1990 PEW-DGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P + + Y + RD+ + ME V +T + L + TY +++ A
Sbjct: 942 PVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTGLKPDTTYDVKVRAHTSK 1000
Query: 2048 GLSEPLESDEPFKVIP 2063
G P F+ +P
Sbjct: 1001 G-PGPYSPSVQFRTLP 1015
Score = 78.2 bits (184), Expect = 3e-13
Identities = 81/307 (26%), Positives = 131/307 (42%), Gaps = 26/307 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F++ P Q G C+ P P I W KG++ V ++ V IE D
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEV-IEFD-DGSG 79
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
SVL+I ++ E Y VA N GE S+ L + ++ P P + + +V +
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 749 GESVILSAQVVGNPRPTITWCK---------NNKPVKALPTKSDGDT--HSITILKPKKV 797
+ + GNP P ITW K NN +K L ++S G T ++ +
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 798 KDEGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D+G Y A NS G ++ A + V E E PP F + G++ +
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+P+P + W E ++P + + G N+ L + +V S +Y CVA ++ G
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMP---IGRNV-LELNDVR---QSANYTCVAMSTLGVIE 312
Query: 917 HGARVTI 923
A++T+
Sbjct: 313 AIAQITV 319
Score = 73.7 bits (173), Expect = 6e-12
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 19/230 (8%)
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+IT+ PP P VV+EST+ S+TL W +S P++ YII+ K + K
Sbjct: 316 QITVKALPKPPGTP---VVTESTATSITLTW---DSGNPEPVSYYIIQHKPKNSEELYKE 369
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ G + + + + + FR+ A N +G P+E + + A PS ++
Sbjct: 370 ID-GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA--PSSAPRDVQA 426
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTM--WMEVGKVDVNTLKFNIRDLS 2032
RM+ S ++ W PE G + GY + D T+ + WM+ D I +L
Sbjct: 427 RMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQIT--TIGNLV 483
Query: 2033 ENHTYMIRIYARNEIGLSEPLESDEPFKV---IPGEGSHADEEPGEQTEV 2079
TY +++ A IG PL SD +PG+ + EP +T +
Sbjct: 484 PQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Score = 65.7 bits (153), Expect = 2e-09
Identities = 76/311 (24%), Positives = 121/311 (38%), Gaps = 39/311 (12%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV-FPEDAGTFT 582
G F CQ G PRP+I W ++ + + + +DD + + L I+ + P D +
Sbjct: 38 GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYE 97
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N G S +T L V I G PT P+
Sbjct: 98 CVASNNVGEISVSTRLTV----------------------LREDQIPRGF-PTIDMGPQL 134
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC------SVLK 696
+ V+ + C P+P+I W FK V N + I+ L+
Sbjct: 135 KVVERTRTATMLCAASGNPDPEITW-FKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQ 193
Query: 697 ITNVKKFQEGTYTVVAVNREG-EASLP---IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
I ++ +G Y VA N G S P V +++ + PP+ P + + G SV
Sbjct: 194 IEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV 253
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ VG+P P + W + + T D +L+ V+ YT A ++ G
Sbjct: 254 NITCVAVGSPMPYVKWMLGAEDL----TPEDDMPIGRNVLELNDVRQSANYTCVAMSTLG 309
Query: 813 IAETSAVITVE 823
+ E A ITV+
Sbjct: 310 VIEAIAQITVK 320
Score = 53.2 bits (122), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 54/435 (12%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQD---FQMYYDDDNVAT-----LVIREVFPED 577
T C G P P+ITWF+ + S + + + T L I + D
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 578 AGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFS 637
G + CVA N+AG S AP + + E+ + +PP FS
Sbjct: 202 QGKYECVATNSAGTRYS-------APANLYVRELRE---------------VRRVPPRFS 239
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
P + G + + C V P P + W+ E++ P E DM + +VL++
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTP--------EDDMPIGRNVLEL 291
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILS 755
+V+ Q YT VA++ G + +K K P P V E + I +S
Sbjct: 292 NDVR--QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS---- 345
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
GNP P + +KP + + D + T + Y + I
Sbjct: 346 ----GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 816 TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
V T E A P R + + TI + + P I YR + P
Sbjct: 402 GPPSEPVLTQTSEQA--PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDP 459
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDY--KCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ + + IT + + + Y K +A S G + + + + +
Sbjct: 460 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 934 LQKSYETEEGKTVIL 948
L E E +++L
Sbjct: 520 LNFKAEPESETSILL 534
Score = 51.6 bits (118), Expect = 3e-05
Identities = 65/275 (23%), Positives = 107/275 (38%), Gaps = 22/275 (8%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP-VIMREISRESVTIEWKPP 1690
I L+ S T+ A T G + V + P P +++ + I+W PP
Sbjct: 787 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPP 846
Query: 1691 LDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS 1750
+D G L Y ++ D + + + + +++ Y+FR+ A+N VGF
Sbjct: 847 VDTFG-PLQGYRLKFGRKDMEP-LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904
Query: 1751 EALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKV--- 1804
E + E I +VP+ + SV ++W P +E+NG I Y +
Sbjct: 905 EEMVKE---ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYR 959
Query: 1805 EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLT 1864
+I + + L +TTY ++ A G PY+ + +TL
Sbjct: 960 DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQF---RTL- 1014
Query: 1865 PPSQ--PRNFVVSESTSRSVTLKWTEPES-NGGSP 1896
P Q +NF V SV L W PE+ N P
Sbjct: 1015 PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMP 1049
>AL137125-1|CAH70912.2| 1912|Homo sapiens protein tyrosine
phosphatase, receptor type, D protein.
Length = 1912
Score = 107 bits (258), Expect = 3e-22
Identities = 220/1036 (21%), Positives = 393/1036 (37%), Gaps = 111/1036 (10%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID- 1157
T E PP +Q G A+F + T GD + W K G ++ + D
Sbjct: 18 TDAETPPRFTRTPVDQTGVSGGVASFICQAT-GDPRPKIVWNKKGKKVSNQRFEVIEFDD 76
Query: 1158 GKKQKLKIYDCDLD-DAGEYSCEVGN-----SKCTAILTVEEPSI--NF-TLRL-PEFIL 1207
G L+I D Y C N S T + + E I F T+ + P+ +
Sbjct: 77 GSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKV 136
Query: 1208 VP-ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRT---------LIIRK 1257
V T L + ++TW+K ++ + I ++ + L I +
Sbjct: 137 VERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQ 196
Query: 1258 CTEDDQCEYTCVLLDAKST-----TKLKV----EVVEFPPKIVDYEREYRIKRGSDVTLL 1308
E DQ +Y CV ++ T L V EV PP+ + I G V +
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNIT 256
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P +W++ ++ + P D ++ + + Y + G
Sbjct: 257 CVAVGSPMPYVKWMLGAEDLT------PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGV 310
Query: 1369 ADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTE- 1426
+ +T+ P PPG P + E ++SI + WD +GN + YY+++++ ++ E
Sbjct: 311 IEAIAQITVKALPKPPGTPVVTESTATSITLTWD----SGNPEPVSYYIIQHKPKNSEEL 366
Query: 1427 WISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPT--- 1483
+ + + T+ S+ L S Y FR AVN + SE V+ +T Q+P+
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSE-----PVLTQTSEQAPSSAP 421
Query: 1484 --VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKK--LKTAKATYENRXXXXXXX 1539
V+ + + TT + E G + +V + D + K +
Sbjct: 422 RDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN 481
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGI 1599
K +AF G+ S IQ + + + K + E T+++
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSS--DIQVITQTGVPGQPLNFKAEPESE---TSILLSW 536
Query: 1600 PPPEVIWYKNGNKLEND----KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT--AGT 1653
PP N + D +E IT + TS R++ LK + + + A + G
Sbjct: 537 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1654 SSVEVTLK-VYDKPSKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPD-- 1709
S+ E++ + + KPS P + S S+ + W+ PP++ +T+Y+I+ D
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1710 NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
+++ ++ + D Y +++L + EY V A VG ES ++I+T DVPS
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPESLSVLIRTNEDVPSG 713
Query: 1770 XXXXXXXXXIDNESVYITW---FPSEKNG---GSPIIDYKVE------------IKQEGK 1811
+++ SV ++W P++++G G + ++E +
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 1812 KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRN 1871
+W+ I L T+Y + A G S K+ + T P +PR
Sbjct: 774 QWEFDDTTEHDMI-ISGLQPETSYSLTVTAYTTKGDGA--RSKPKL-VSTTGAVPGKPR- 828
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE--HCIEN 1929
V++ + + ++W P G P+ Y ++F K + T+ S E +
Sbjct: 829 LVINHTQMNTALIQWHPPVDTFG-PLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATD 884
Query: 1930 IKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGT 1989
I + +FR+SA N VG E + VP+ L S V SW
Sbjct: 885 IHKGASYVFRLSARNKVGFG---EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQP 941
Query: 1990 PEW-DGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P + + Y + RD+ + ME V +T + L + TY +++ A
Sbjct: 942 PVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-TMTLTGLKPDTTYDVKVRAHTSK 1000
Query: 2048 GLSEPLESDEPFKVIP 2063
G P F+ +P
Sbjct: 1001 G-PGPYSPSVQFRTLP 1015
Score = 78.2 bits (184), Expect = 3e-13
Identities = 81/307 (26%), Positives = 131/307 (42%), Gaps = 26/307 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F++ P Q G C+ P P I W KG++ V ++ V IE D
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKK-VSNQRFEV-IEFD-DGSG 79
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
SVL+I ++ E Y VA N GE S+ L + ++ P P + + +V +
Sbjct: 80 SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139
Query: 749 GESVILSAQVVGNPRPTITWCK---------NNKPVKALPTKSDGDT--HSITILKPKKV 797
+ + GNP P ITW K NN +K L ++S G T ++ +
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199
Query: 798 KDEGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
D+G Y A NS G ++ A + V E E PP F + G++ +
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
+P+P + W E ++P + + G N+ L + +V S +Y CVA ++ G
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMP---IGRNV-LELNDVR---QSANYTCVAMSTLGVIE 312
Query: 917 HGARVTI 923
A++T+
Sbjct: 313 AIAQITV 319
Score = 73.7 bits (173), Expect = 6e-12
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 19/230 (8%)
Query: 1856 KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI 1915
+IT+ PP P VV+EST+ S+TL W +S P++ YII+ K + K
Sbjct: 316 QITVKALPKPPGTP---VVTESTATSITLTW---DSGNPEPVSYYIIQHKPKNSEELYKE 369
Query: 1916 VTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
+ G + + + + + FR+ A N +G P+E + + A PS ++
Sbjct: 370 ID-GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA--PSSAPRDVQA 426
Query: 1976 RMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTM--WMEVGKVDVNTLKFNIRDLS 2032
RM+ S ++ W PE G + GY + D T+ + WM+ D I +L
Sbjct: 427 RMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNWMKHNVADSQIT--TIGNLV 483
Query: 2033 ENHTYMIRIYARNEIGLSEPLESDEPFKV---IPGEGSHADEEPGEQTEV 2079
TY +++ A IG PL SD +PG+ + EP +T +
Sbjct: 484 PQKTYSVKVLAFTSIG-DGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Score = 65.7 bits (153), Expect = 2e-09
Identities = 76/311 (24%), Positives = 121/311 (38%), Gaps = 39/311 (12%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV-FPEDAGTFT 582
G F CQ G PRP+I W ++ + + + +DD + + L I+ + P D +
Sbjct: 38 GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYE 97
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N G S +T L V I G PT P+
Sbjct: 98 CVASNNVGEISVSTRLTV----------------------LREDQIPRGF-PTIDMGPQL 134
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC------SVLK 696
+ V+ + C P+P+I W FK V N + I+ L+
Sbjct: 135 KVVERTRTATMLCAASGNPDPEITW-FKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQ 193
Query: 697 ITNVKKFQEGTYTVVAVNREG-EASLP---IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
I ++ +G Y VA N G S P V +++ + PP+ P + + G SV
Sbjct: 194 IEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV 253
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ VG+P P + W + + T D +L+ V+ YT A ++ G
Sbjct: 254 NITCVAVGSPMPYVKWMLGAEDL----TPEDDMPIGRNVLELNDVRQSANYTCVAMSTLG 309
Query: 813 IAETSAVITVE 823
+ E A ITV+
Sbjct: 310 VIEAIAQITVK 320
Score = 53.2 bits (122), Expect = 1e-05
Identities = 92/435 (21%), Positives = 153/435 (35%), Gaps = 54/435 (12%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQD---FQMYYDDDNVAT-----LVIREVFPED 577
T C G P P+ITWF+ + S + + + T L I + D
Sbjct: 142 TATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 578 AGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFS 637
G + CVA N+AG S AP + + E+ + +PP FS
Sbjct: 202 QGKYECVATNSAGTRYS-------APANLYVRELRE---------------VRRVPPRFS 239
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
P + G + + C V P P + W+ E++ P E DM + +VL++
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTP--------EDDMPIGRNVLEL 291
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP--PQVIEPLKSMIVRQGESVILS 755
+V+ Q YT VA++ G + +K K P P V E + I +S
Sbjct: 292 NDVR--QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDS---- 345
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAE 815
GNP P + +KP + + D + T + Y + I
Sbjct: 346 ----GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGR 401
Query: 816 TSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP 875
V T E A P R + + TI + + P I YR + P
Sbjct: 402 GPPSEPVLTQTSEQA--PSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDP 459
Query: 876 SETITQNFDGENIELVITNVDSEIDSGDY--KCVASNSAGKSSHGARVTIDVEKVTFVKH 933
++ + + IT + + + Y K +A S G + + + + +
Sbjct: 460 TQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP 519
Query: 934 LQKSYETEEGKTVIL 948
L E E +++L
Sbjct: 520 LNFKAEPESETSILL 534
Score = 51.6 bits (118), Expect = 3e-05
Identities = 65/275 (23%), Positives = 107/275 (38%), Gaps = 22/275 (8%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP-VIMREISRESVTIEWKPP 1690
I L+ S T+ A T G + V + P P +++ + I+W PP
Sbjct: 787 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPP 846
Query: 1691 LDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS 1750
+D G L Y ++ D + + + + +++ Y+FR+ A+N VGF
Sbjct: 847 VDTFG-PLQGYRLKFGRKDMEP-LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904
Query: 1751 EALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKV--- 1804
E + E I +VP+ + SV ++W P +E+NG I Y +
Sbjct: 905 EEMVKE---ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYR 959
Query: 1805 EIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLT 1864
+I + + L +TTY ++ A G PY+ + +TL
Sbjct: 960 DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQF---RTL- 1014
Query: 1865 PPSQ--PRNFVVSESTSRSVTLKWTEPES-NGGSP 1896
P Q +NF V SV L W PE+ N P
Sbjct: 1015 PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMP 1049
>BC130619-1|AAI30620.1| 1100|Homo sapiens CNTN5 protein protein.
Length = 1100
Score = 107 bits (257), Expect = 4e-22
Identities = 182/880 (20%), Positives = 341/880 (38%), Gaps = 72/880 (8%)
Query: 1138 RWFKDGSEIQFSNHIQLT-IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAI---LTVEE 1193
RW ++G+EI + + + IDG + + D+G Y C N+ + + T++
Sbjct: 134 RWLRNGTEIDLESDYRYSLIDGTF--IISNPSEAKDSGHYQCLATNTVGSILSREATLQF 191
Query: 1194 PSI-NFTLRLPEFILVPANTDAYLTVEIPDETLDV--TWYKKKS---VIEDTEKFTLISD 1247
+ NF+ R + V L P + ++ +W + V ED+ +F IS
Sbjct: 192 AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRF--ISQ 249
Query: 1248 VKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK---------LKVEVV--EFPPKI-VDYER 1295
+ L I K D Y C++ + + + L+ + V E+ PKI V +
Sbjct: 250 -ETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPF 308
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWI-VNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
+G+ V + P P W+ VN I K + K A L I V+ D
Sbjct: 309 TVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRK-----SQAVLEIPNVQLDD 363
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
AGIY+ R EN+ G + + P K N ++DS S + W E + TG Y
Sbjct: 364 AGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGS-PLRW-ECKATGKPRPTY 421
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI 1474
++ + + V+ + I N+ + + ++ A N+ AS K++
Sbjct: 422 RWLK-NGVPLSPQSRVEMVNGV-LMIHNVNQSDAGMYQCLAENKYGAIYASAE---LKIL 476
Query: 1475 KETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK-ATYENRX 1533
+ + + K I ++++ + C G P+P ++W + + ++ K
Sbjct: 477 --ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDG 534
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT 1593
Y C N G E + +++ I ++ + + + VG+ ++
Sbjct: 535 SLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPK--RTELTVGESIVLN 592
Query: 1594 --AVIEGIPPPEVIWYKNGNKLENDKE----YNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
A+ + W G ++ ++E +I + ++ + I+ + H+ +Y
Sbjct: 593 CKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRV 652
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
TA + S E L V P P G VI+ EI+ + T+ W P D+ ++ Y ++
Sbjct: 653 QTTADSVSDEAELLVRGPPG-PPGIVIVEEITESTATLSWSPAADNHS-PISSYNLQARS 710
Query: 1708 PDNNRWIKVADVDR----DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTA 1763
P + W V V D+E+ LN EY FRV+A NP+G + + +I+T
Sbjct: 711 PFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDP-STPSRMIRTN 769
Query: 1764 LDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXX 1821
VP + I W P SE+ Y V + G + WK
Sbjct: 770 EAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSS 829
Query: 1822 XXA----RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES 1877
+ R + + T ++ ++ N G P+ S + P + P + +
Sbjct: 830 EASKFIYRDESVPPLTPFEVKVGVYNNKGDG-PF-SQIVVICSAEGEPSAAPTDVKATSV 887
Query: 1878 TSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEII 1937
+ + + W + + G P + +K ++ + + V G+ + ++
Sbjct: 888 SVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYH 947
Query: 1938 FRISAENTVGVSLPTESQSVRLEKHATVPSPPT-APLEIR 1976
F + A N G P+ S +K SPP+ AP +R
Sbjct: 948 FTVRAYNGAGYGPPSSEVSATTKK-----SPPSQAPSNLR 982
Score = 104 bits (249), Expect = 4e-21
Identities = 198/916 (21%), Positives = 352/916 (38%), Gaps = 77/916 (8%)
Query: 833 PLFINRFQEI---TVKEKGTIKLVARVTRNPVPSITWYRNN-EIISPSETITQNFDGENI 888
P+F+ +I T ++ + L V NPVPS W RN EI S+ DG
Sbjct: 99 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGT-- 156
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV-TFVKHLQKSYETEEGKTVI 947
+I+N DSG Y+C+A+N+ G S T+ + F + + EG+ V+
Sbjct: 157 -FIISNPSEAKDSGHYQCLATNTVG-SILSREATLQFAYLGNFSGRTRSAVSVREGQGVV 214
Query: 948 LECQT---SHTVSTKWYHNK-KEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
L C S + W N+ D R I + DVG C+VK+
Sbjct: 215 LMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGSYICLVKN 273
Query: 1004 QETSTMLVVKETIPEFIRK---LQDFEVK-EKDVAILEVEINSETADVVWERDGE----I 1055
T+ ++ T P +R + ++E K E T + G I
Sbjct: 274 TVTNARVLSPPT-PLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 332
Query: 1056 IKPKKNKYDFEKRGHIRK----LYIRNTSVHDEGEYSCIL---RDESCTAEVTVVELPPE 1108
K N Y + +RK L I N + D G Y C R ++ V P
Sbjct: 333 TWMKVNGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPH 391
Query: 1109 IITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
+ +L + +++ G+ +E + T K RW K+G + + +++ ++G L I++
Sbjct: 392 WVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEM-VNG---VLMIHN 447
Query: 1168 CDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTL-RLPEFILVPANTDAYLTVEIPD 1222
+ DAG Y C + G +A L + + F L +L + I+V + + + +
Sbjct: 448 VNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQG 507
Query: 1223 ETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
++W K + + ++ ++ D R L ++ D+ +Y C + + ++
Sbjct: 508 SPKPTISWKKGDRAVRENKRIAILPDGSLRIL---NASKSDEGKYVCRGENVFGSAEIIA 564
Query: 1282 EV-VEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKII---KKCKHTK 1335
+ V+ P +I + + G + L + A W + + I ++ H +
Sbjct: 565 SLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFE 624
Query: 1336 P-SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
+ SA L I+ + AG Y R++ E + + P PPG + EI
Sbjct: 625 SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITE 684
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN----ITKTQTSIQNLKTNS--S 1448
S+ + W P +S I Y ++ + + W +VK IT S + N
Sbjct: 685 STATLSW-SPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 743
Query: 1449 YRFRAYAVNEVDISDAS------ETTEYYKVIKETKIQSPTVEKPLKNITTEP-NEDIEL 1501
Y FR A N + D S T E T + + + I EP +E+ +
Sbjct: 744 YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQN 803
Query: 1502 TCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
FG + + R G K K ++ ++ K +N+ G+
Sbjct: 804 GEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPF 862
Query: 1562 SCVVGI-QQKPVITISNEDIKQKHKVGDEWLVT--AVIEGIPPP---EVIWYKNGNKLEN 1615
S +V I + + + D+K E LV + E + P EV ++K+ +
Sbjct: 863 SQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME--QE 920
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP-EGPVI 1674
D + T+ S + + L+ + +T+ A N AG + K S P + P
Sbjct: 921 DTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSN 980
Query: 1675 MR-EISRESVTIEWKP 1689
+R E V++ W+P
Sbjct: 981 LRWEQQGSQVSLGWEP 996
Score = 85.4 bits (202), Expect = 2e-15
Identities = 69/235 (29%), Positives = 107/235 (45%), Gaps = 19/235 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P + +K +D GS + EC+ P P WL G + P +S + M
Sbjct: 390 PHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP--------QSRVEMVNG 441
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLK-SMIVRQGESV 752
VL I NV + G Y +A N+ G LKI P + LK ++IV + + V
Sbjct: 442 VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKDQEV 499
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G+P+PTI+W K ++ V+ + S+ IL K DEG Y + EN G
Sbjct: 500 VIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK-SDEGKYVCRGENVFG 558
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
AE A ++V+EPT P + E+TV E +I L + + +T+Y
Sbjct: 559 SAEIIASLSVKEPTRIELTP-----KRTELTVGE--SIVLNCKAIHDASLDVTFY 606
Score = 83.4 bits (197), Expect = 8e-15
Identities = 110/464 (23%), Positives = 184/464 (39%), Gaps = 39/464 (8%)
Query: 645 VDEGSDILLECRLVA-IPEPDIAWLFKG-EEIVPDENISVAIESDMHMYCSVLKITNVKK 702
V EG ++L C PE +W+F V +++ + ++Y S ++ ++V
Sbjct: 207 VREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS 266
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQGESVILSAQVVG 760
+ V R P+ L+ GE EP + ++ +G +V + +G
Sbjct: 267 YICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALG 326
Query: 761 NPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
NP PTITW K N P KA KS ++ + ++ D G+Y +AENS G
Sbjct: 327 NPVPTITWMKVNGYIPSKARLRKS----QAVLEIPNVQLDDAGIYECRAENSRGKNSFRG 382
Query: 819 VITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET 878
+ V P ++ + + + ++ + T P P+ W +N +SP
Sbjct: 383 QLQV-------YTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSR 435
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF-VKHLQKS 937
+ + N L+I NV ++ D+G Y+C+A N G A + I TF + L+K+
Sbjct: 436 V----EMVNGVLMIHNV-NQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKT 490
Query: 938 YETEEGKTVILEC--QTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVG 995
+ + V++EC Q S + W + + I+ +G D G
Sbjct: 491 IIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDG---SLRILNASKSDEG 547
Query: 996 VIKC----IVKDQETSTMLVVKE-TIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-- 1048
C + E L VKE T E K + V E V + I+ + DV
Sbjct: 548 KYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA-IHDASLDVTFY 606
Query: 1049 WERDGEIIKPKKNKYDFEK---RGHIRKLYIRNTSVHDEGEYSC 1089
W G+ I ++ FE + L IRN + G Y C
Sbjct: 607 WTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGC 650
Score = 56.8 bits (131), Expect = 8e-07
Identities = 113/529 (21%), Positives = 201/529 (37%), Gaps = 55/529 (10%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSIT 790
+EP +I P S + V L+ +V GNP P+ W +N + + +
Sbjct: 103 QEPDDIIFPTDS----DEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFI 158
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE-ITVKE-KG 848
I P + KD G Y A N+ G I E T + A F R + ++V+E +G
Sbjct: 159 ISNPSEAKDSGHYQCLATNTVG------SILSREATLQFAYLGNFSGRTRSAVSVREGQG 212
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVA 908
+ + + +P +W N +E + E L I+ V + D G Y C+
Sbjct: 213 VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTS-DVGSYICLV 271
Query: 909 SNSAGKS---SHGARVTIDVEKV------TFVKHLQKSYETEEGKTVILEC-QTSHTVST 958
N+ + S +T+ + V H + +G TV +EC + V T
Sbjct: 272 KNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT 331
Query: 959 -KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTML---VVKE 1014
W +++G + D G+ +C ++ +
Sbjct: 332 ITW----MKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRK 1073
T P ++ KL D ++ E + + W ++G + P+ E +
Sbjct: 388 TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSR---VEMVNGV-- 442
Query: 1074 LYIRNTSVHDEGEYSCILRDE----SCTAEVTVVELPPEI-ITRLQNQ-KVNKGNKATFE 1127
L I N + D G Y C+ ++ +AE+ ++ P + +L+ V K + E
Sbjct: 443 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIE 502
Query: 1128 IE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGN 1182
+ + W K ++ + I + DG L+I + D G+Y C G+
Sbjct: 503 CKPQGSPKPTISWKKGDRAVRENKRIAILPDG---SLRILNASKSDEGKYVCRGENVFGS 559
Query: 1183 SKCTAILTVEEPS-INFTLRLPEFILVPANTDAYLTVEIPDETLDVTWY 1230
++ A L+V+EP+ I T + E L + I D +LDVT+Y
Sbjct: 560 AEIIASLSVKEPTRIELTPKRTE--LTVGESIVLNCKAIHDASLDVTFY 606
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 7/96 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +VEKL GS +++EC+ G PRP W + + P +M L+
Sbjct: 390 PHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVN-----GVLM 444
Query: 570 IREVFPEDAGTFTCVAKNAAG--FASSTTELIVEAP 603
I V DAG + C+A+N G +AS+ +++ AP
Sbjct: 445 IHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP 480
Score = 38.7 bits (86), Expect = 0.23
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV+ EC G P P ITW + I + + A L I V +DAG + C
Sbjct: 315 GTTVKMECFALGNPVPTITWMKVNGYIPSKARLR-----KSQAVLEIPNVQLDDAGIYEC 369
Query: 584 VAKNAAGFASSTTELIV 600
A+N+ G S +L V
Sbjct: 370 RAENSRGKNSFRGQLQV 386
Score = 35.9 bits (79), Expect = 1.6
Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 8/91 (8%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V EC+ +G P+P I+W + ++ ++ + D +L I D G + C +
Sbjct: 499 VVIECKPQGSPKPTISWKKGDRAVRENKRIAILPD----GSLRILNASKSDEGKYVCRGE 554
Query: 587 NAAGFASSTTELIVEAP----LSDHGSEMTV 613
N G A L V+ P L+ +E+TV
Sbjct: 555 NVFGSAEIIASLSVKEPTRIELTPKRTELTV 585
Score = 35.1 bits (77), Expect = 2.8
Identities = 23/90 (25%), Positives = 35/90 (38%), Gaps = 5/90 (5%)
Query: 504 EEQSMAPIFVEKLRPKHTP---DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
E P+FV++ P D V C+V G P P W R I D++
Sbjct: 93 ESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSL 152
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
D ++ +D+G + C+A N G
Sbjct: 153 IDGTF--IISNPSEAKDSGHYQCLATNTVG 180
>AB013803-1|BAA36580.2| 1026|Homo sapiens hNB-2s protein.
Length = 1026
Score = 107 bits (257), Expect = 4e-22
Identities = 182/880 (20%), Positives = 341/880 (38%), Gaps = 72/880 (8%)
Query: 1138 RWFKDGSEIQFSNHIQLT-IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAI---LTVEE 1193
RW ++G+EI + + + IDG + + D+G Y C N+ + + T++
Sbjct: 60 RWLRNGTEIDLESDYRYSLIDGTF--IISNPSEAKDSGHYQCLATNTVGSILSREATLQF 117
Query: 1194 PSI-NFTLRLPEFILVPANTDAYLTVEIPDETLDV--TWYKKKS---VIEDTEKFTLISD 1247
+ NF+ R + V L P + ++ +W + V ED+ +F IS
Sbjct: 118 AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRF--ISQ 175
Query: 1248 VKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK---------LKVEVV--EFPPKI-VDYER 1295
+ L I K D Y C++ + + + L+ + V E+ PKI V +
Sbjct: 176 -ETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPF 234
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWI-VNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
+G+ V + P P W+ VN I K + K A L I V+ D
Sbjct: 235 TVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRK-----SQAVLEIPNVQLDD 289
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
AGIY+ R EN+ G + + P K N ++DS S + W E + TG Y
Sbjct: 290 AGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGS-PLRW-ECKATGKPRPTY 347
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI 1474
++ + + V+ + I N+ + + ++ A N+ AS K++
Sbjct: 348 RWLK-NGVPLSPQSRVEMVNGV-LMIHNVNQSDAGMYQCLAENKYGAIYASAE---LKIL 402
Query: 1475 KETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK-ATYENRX 1533
+ + + K I ++++ + C G P+P ++W + + ++ K
Sbjct: 403 --ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDG 460
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT 1593
Y C N G E + +++ I ++ + + + VG+ ++
Sbjct: 461 SLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPK--RTELTVGESIVLN 518
Query: 1594 --AVIEGIPPPEVIWYKNGNKLENDKE----YNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
A+ + W G ++ ++E +I + ++ + I+ + H+ +Y
Sbjct: 519 CKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRV 578
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
TA + S E L V P P G VI+ EI+ + T+ W P D+ ++ Y ++
Sbjct: 579 QTTADSVSDEAELLVRGPPG-PPGIVIVEEITESTATLSWSPAADNHS-PISSYNLQARS 636
Query: 1708 PDNNRWIKVADVDR----DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTA 1763
P + W V V D+E+ LN EY FRV+A NP+G + + +I+T
Sbjct: 637 PFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDP-STPSRMIRTN 695
Query: 1764 LDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXX 1821
VP + I W P SE+ Y V + G + WK
Sbjct: 696 EAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSS 755
Query: 1822 XXA----RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES 1877
+ R + + T ++ ++ N G P+ S + P + P + +
Sbjct: 756 EASKFIYRDESVPPLTPFEVKVGVYNNKGDG-PF-SQIVVICSAEGEPSAAPTDVKATSV 813
Query: 1878 TSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEII 1937
+ + + W + + G P + +K ++ + + V G+ + ++
Sbjct: 814 SVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYH 873
Query: 1938 FRISAENTVGVSLPTESQSVRLEKHATVPSPPT-APLEIR 1976
F + A N G P+ S +K SPP+ AP +R
Sbjct: 874 FTVRAYNGAGYGPPSSEVSATTKK-----SPPSQAPSNLR 908
Score = 104 bits (249), Expect = 4e-21
Identities = 198/916 (21%), Positives = 352/916 (38%), Gaps = 77/916 (8%)
Query: 833 PLFINRFQEI---TVKEKGTIKLVARVTRNPVPSITWYRNN-EIISPSETITQNFDGENI 888
P+F+ +I T ++ + L V NPVPS W RN EI S+ DG
Sbjct: 25 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGT-- 82
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV-TFVKHLQKSYETEEGKTVI 947
+I+N DSG Y+C+A+N+ G S T+ + F + + EG+ V+
Sbjct: 83 -FIISNPSEAKDSGHYQCLATNTVG-SILSREATLQFAYLGNFSGRTRSAVSVREGQGVV 140
Query: 948 LECQT---SHTVSTKWYHNK-KEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
L C S + W N+ D R I + DVG C+VK+
Sbjct: 141 LMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGSYICLVKN 199
Query: 1004 QETSTMLVVKETIPEFIRK---LQDFEVK-EKDVAILEVEINSETADVVWERDGE----I 1055
T+ ++ T P +R + ++E K E T + G I
Sbjct: 200 TVTNARVLSPPT-PLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 258
Query: 1056 IKPKKNKYDFEKRGHIRK----LYIRNTSVHDEGEYSCIL---RDESCTAEVTVVELPPE 1108
K N Y + +RK L I N + D G Y C R ++ V P
Sbjct: 259 TWMKVNGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPH 317
Query: 1109 IITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
+ +L + +++ G+ +E + T K RW K+G + + +++ ++G L I++
Sbjct: 318 WVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEM-VNG---VLMIHN 373
Query: 1168 CDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTL-RLPEFILVPANTDAYLTVEIPD 1222
+ DAG Y C + G +A L + + F L +L + I+V + + + +
Sbjct: 374 VNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQG 433
Query: 1223 ETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
++W K + + ++ ++ D R L ++ D+ +Y C + + ++
Sbjct: 434 SPKPTISWKKGDRAVRENKRIAILPDGSLRIL---NASKSDEGKYVCRGENVFGSAEIIA 490
Query: 1282 EV-VEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKII---KKCKHTK 1335
+ V+ P +I + + G + L + A W + + I ++ H +
Sbjct: 491 SLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFE 550
Query: 1336 P-SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
+ SA L I+ + AG Y R++ E + + P PPG + EI
Sbjct: 551 SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITE 610
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN----ITKTQTSIQNLKTNS--S 1448
S+ + W P +S I Y ++ + + W +VK IT S + N
Sbjct: 611 STATLSW-SPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 669
Query: 1449 YRFRAYAVNEVDISDAS------ETTEYYKVIKETKIQSPTVEKPLKNITTEP-NEDIEL 1501
Y FR A N + D S T E T + + + I EP +E+ +
Sbjct: 670 YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQN 729
Query: 1502 TCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
FG + + R G K K ++ ++ K +N+ G+
Sbjct: 730 GEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPF 788
Query: 1562 SCVVGI-QQKPVITISNEDIKQKHKVGDEWLVT--AVIEGIPPP---EVIWYKNGNKLEN 1615
S +V I + + + D+K E LV + E + P EV ++K+ +
Sbjct: 789 SQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME--QE 846
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP-EGPVI 1674
D + T+ S + + L+ + +T+ A N AG + K S P + P
Sbjct: 847 DTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSN 906
Query: 1675 MR-EISRESVTIEWKP 1689
+R E V++ W+P
Sbjct: 907 LRWEQQGSQVSLGWEP 922
Score = 85.4 bits (202), Expect = 2e-15
Identities = 69/235 (29%), Positives = 107/235 (45%), Gaps = 19/235 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P + +K +D GS + EC+ P P WL G + P +S + M
Sbjct: 316 PHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP--------QSRVEMVNG 367
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLK-SMIVRQGESV 752
VL I NV + G Y +A N+ G LKI P + LK ++IV + + V
Sbjct: 368 VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKDQEV 425
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G+P+PTI+W K ++ V+ + S+ IL K DEG Y + EN G
Sbjct: 426 VIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK-SDEGKYVCRGENVFG 484
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
AE A ++V+EPT P + E+TV E +I L + + +T+Y
Sbjct: 485 SAEIIASLSVKEPTRIELTP-----KRTELTVGE--SIVLNCKAIHDASLDVTFY 532
Score = 83.4 bits (197), Expect = 8e-15
Identities = 110/464 (23%), Positives = 184/464 (39%), Gaps = 39/464 (8%)
Query: 645 VDEGSDILLECRLVA-IPEPDIAWLFKG-EEIVPDENISVAIESDMHMYCSVLKITNVKK 702
V EG ++L C PE +W+F V +++ + ++Y S ++ ++V
Sbjct: 133 VREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS 192
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQGESVILSAQVVG 760
+ V R P+ L+ GE EP + ++ +G +V + +G
Sbjct: 193 YICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALG 252
Query: 761 NPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
NP PTITW K N P KA KS ++ + ++ D G+Y +AENS G
Sbjct: 253 NPVPTITWMKVNGYIPSKARLRKS----QAVLEIPNVQLDDAGIYECRAENSRGKNSFRG 308
Query: 819 VITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET 878
+ V P ++ + + + ++ + T P P+ W +N +SP
Sbjct: 309 QLQV-------YTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSR 361
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF-VKHLQKS 937
+ + N L+I NV ++ D+G Y+C+A N G A + I TF + L+K+
Sbjct: 362 V----EMVNGVLMIHNV-NQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKT 416
Query: 938 YETEEGKTVILEC--QTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVG 995
+ + V++EC Q S + W + + I+ +G D G
Sbjct: 417 IIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDG---SLRILNASKSDEG 473
Query: 996 VIKC----IVKDQETSTMLVVKE-TIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-- 1048
C + E L VKE T E K + V E V + I+ + DV
Sbjct: 474 KYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA-IHDASLDVTFY 532
Query: 1049 WERDGEIIKPKKNKYDFEK---RGHIRKLYIRNTSVHDEGEYSC 1089
W G+ I ++ FE + L IRN + G Y C
Sbjct: 533 WTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGC 576
Score = 56.8 bits (131), Expect = 8e-07
Identities = 113/529 (21%), Positives = 201/529 (37%), Gaps = 55/529 (10%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSIT 790
+EP +I P S + V L+ +V GNP P+ W +N + + +
Sbjct: 29 QEPDDIIFPTDS----DEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFI 84
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE-ITVKE-KG 848
I P + KD G Y A N+ G I E T + A F R + ++V+E +G
Sbjct: 85 ISNPSEAKDSGHYQCLATNTVG------SILSREATLQFAYLGNFSGRTRSAVSVREGQG 138
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVA 908
+ + + +P +W N +E + E L I+ V + D G Y C+
Sbjct: 139 VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTS-DVGSYICLV 197
Query: 909 SNSAGKS---SHGARVTIDVEKV------TFVKHLQKSYETEEGKTVILEC-QTSHTVST 958
N+ + S +T+ + V H + +G TV +EC + V T
Sbjct: 198 KNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT 257
Query: 959 -KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTML---VVKE 1014
W +++G + D G+ +C ++ +
Sbjct: 258 ITW----MKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 313
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRK 1073
T P ++ KL D ++ E + + W ++G + P+ E +
Sbjct: 314 TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSR---VEMVNGV-- 368
Query: 1074 LYIRNTSVHDEGEYSCILRDE----SCTAEVTVVELPPEI-ITRLQNQ-KVNKGNKATFE 1127
L I N + D G Y C+ ++ +AE+ ++ P + +L+ V K + E
Sbjct: 369 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIE 428
Query: 1128 IE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGN 1182
+ + W K ++ + I + DG L+I + D G+Y C G+
Sbjct: 429 CKPQGSPKPTISWKKGDRAVRENKRIAILPDG---SLRILNASKSDEGKYVCRGENVFGS 485
Query: 1183 SKCTAILTVEEPS-INFTLRLPEFILVPANTDAYLTVEIPDETLDVTWY 1230
++ A L+V+EP+ I T + E L + I D +LDVT+Y
Sbjct: 486 AEIIASLSVKEPTRIELTPKRTE--LTVGESIVLNCKAIHDASLDVTFY 532
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 7/96 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +VEKL GS +++EC+ G PRP W + + P +M L+
Sbjct: 316 PHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVN-----GVLM 370
Query: 570 IREVFPEDAGTFTCVAKNAAG--FASSTTELIVEAP 603
I V DAG + C+A+N G +AS+ +++ AP
Sbjct: 371 IHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP 406
Score = 38.7 bits (86), Expect = 0.23
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV+ EC G P P ITW + I + + A L I V +DAG + C
Sbjct: 241 GTTVKMECFALGNPVPTITWMKVNGYIPSKARLR-----KSQAVLEIPNVQLDDAGIYEC 295
Query: 584 VAKNAAGFASSTTELIV 600
A+N+ G S +L V
Sbjct: 296 RAENSRGKNSFRGQLQV 312
Score = 36.7 bits (81), Expect = 0.91
Identities = 24/91 (26%), Positives = 36/91 (39%), Gaps = 5/91 (5%)
Query: 503 SEEQSMAPIFVEKLRPKHTP---DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
SE P+FV++ P D V C+V G P P W R I D++
Sbjct: 18 SESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS 77
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
D ++ +D+G + C+A N G
Sbjct: 78 LIDGTF--IISNPSEAKDSGHYQCLATNTVG 106
Score = 35.9 bits (79), Expect = 1.6
Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 8/91 (8%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V EC+ +G P+P I+W + ++ ++ + D +L I D G + C +
Sbjct: 425 VVIECKPQGSPKPTISWKKGDRAVRENKRIAILPD----GSLRILNASKSDEGKYVCRGE 480
Query: 587 NAAGFASSTTELIVEAP----LSDHGSEMTV 613
N G A L V+ P L+ +E+TV
Sbjct: 481 NVFGSAEIIASLSVKEPTRIELTPKRTELTV 511
>AB013802-1|BAA36579.2| 1100|Homo sapiens hNB-2 protein.
Length = 1100
Score = 107 bits (257), Expect = 4e-22
Identities = 182/880 (20%), Positives = 341/880 (38%), Gaps = 72/880 (8%)
Query: 1138 RWFKDGSEIQFSNHIQLT-IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAI---LTVEE 1193
RW ++G+EI + + + IDG + + D+G Y C N+ + + T++
Sbjct: 134 RWLRNGTEIDLESDYRYSLIDGTF--IISNPSEAKDSGHYQCLATNTVGSILSREATLQF 191
Query: 1194 PSI-NFTLRLPEFILVPANTDAYLTVEIPDETLDV--TWYKKKS---VIEDTEKFTLISD 1247
+ NF+ R + V L P + ++ +W + V ED+ +F IS
Sbjct: 192 AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRF--ISQ 249
Query: 1248 VKKRTLIIRKCTEDDQCEYTCVLLDAKSTTK---------LKVEVV--EFPPKI-VDYER 1295
+ L I K D Y C++ + + + L+ + V E+ PKI V +
Sbjct: 250 -ETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPF 308
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWI-VNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
+G+ V + P P W+ VN I K + K A L I V+ D
Sbjct: 309 TVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRK-----SQAVLEIPNVQLDD 363
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
AGIY+ R EN+ G + + P K N ++DS S + W E + TG Y
Sbjct: 364 AGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGS-PLRW-ECKATGKPRPTY 421
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI 1474
++ + + V+ + I N+ + + ++ A N+ AS K++
Sbjct: 422 RWLK-NGVPLSPQSRVEMVNGV-LMIHNVNQSDAGMYQCLAENKYGAIYASAE---LKIL 476
Query: 1475 KETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK-ATYENRX 1533
+ + + K I ++++ + C G P+P ++W + + ++ K
Sbjct: 477 --ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDG 534
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT 1593
Y C N G E + +++ I ++ + + + VG+ ++
Sbjct: 535 SLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPK--RTELTVGESIVLN 592
Query: 1594 --AVIEGIPPPEVIWYKNGNKLENDKE----YNITTKEKTSVIRIKELKRSHSSKYTIEA 1647
A+ + W G ++ ++E +I + ++ + I+ + H+ +Y
Sbjct: 593 CKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRV 652
Query: 1648 SNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
TA + S E L V P P G VI+ EI+ + T+ W P D+ ++ Y ++
Sbjct: 653 QTTADSVSDEAELLVRGPPG-PPGIVIVEEITESTATLSWSPAADNHS-PISSYNLQARS 710
Query: 1708 PDNNRWIKVADVDR----DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTA 1763
P + W V V D+E+ LN EY FRV+A NP+G + + +I+T
Sbjct: 711 PFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDP-STPSRMIRTN 769
Query: 1764 LDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXX 1821
VP + I W P SE+ Y V + G + WK
Sbjct: 770 EAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSS 829
Query: 1822 XXA----RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSES 1877
+ R + + T ++ ++ N G P+ S + P + P + +
Sbjct: 830 EASKFIYRDESVPPLTPFEVKVGVYNNKGDG-PF-SQIVVICSAEGEPSAAPTDVKATSV 887
Query: 1878 TSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEII 1937
+ + + W + + G P + +K ++ + + V G+ + ++
Sbjct: 888 SVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYH 947
Query: 1938 FRISAENTVGVSLPTESQSVRLEKHATVPSPPT-APLEIR 1976
F + A N G P+ S +K SPP+ AP +R
Sbjct: 948 FTVRAYNGAGYGPPSSEVSATTKK-----SPPSQAPSNLR 982
Score = 104 bits (249), Expect = 4e-21
Identities = 198/916 (21%), Positives = 352/916 (38%), Gaps = 77/916 (8%)
Query: 833 PLFINRFQEI---TVKEKGTIKLVARVTRNPVPSITWYRNN-EIISPSETITQNFDGENI 888
P+F+ +I T ++ + L V NPVPS W RN EI S+ DG
Sbjct: 99 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGT-- 156
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKV-TFVKHLQKSYETEEGKTVI 947
+I+N DSG Y+C+A+N+ G S T+ + F + + EG+ V+
Sbjct: 157 -FIISNPSEAKDSGHYQCLATNTVG-SILSREATLQFAYLGNFSGRTRSAVSVREGQGVV 214
Query: 948 LECQT---SHTVSTKWYHNK-KEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
L C S + W N+ D R I + DVG C+VK+
Sbjct: 215 LMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGSYICLVKN 273
Query: 1004 QETSTMLVVKETIPEFIRK---LQDFEVK-EKDVAILEVEINSETADVVWERDGE----I 1055
T+ ++ T P +R + ++E K E T + G I
Sbjct: 274 TVTNARVLSPPT-PLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTI 332
Query: 1056 IKPKKNKYDFEKRGHIRK----LYIRNTSVHDEGEYSCIL---RDESCTAEVTVVELPPE 1108
K N Y + +RK L I N + D G Y C R ++ V P
Sbjct: 333 TWMKVNGY-IPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPH 391
Query: 1109 IITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYD 1167
+ +L + +++ G+ +E + T K RW K+G + + +++ ++G L I++
Sbjct: 392 WVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEM-VNG---VLMIHN 447
Query: 1168 CDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTL-RLPEFILVPANTDAYLTVEIPD 1222
+ DAG Y C + G +A L + + F L +L + I+V + + + +
Sbjct: 448 VNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQG 507
Query: 1223 ETL-DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV 1281
++W K + + ++ ++ D R L ++ D+ +Y C + + ++
Sbjct: 508 SPKPTISWKKGDRAVRENKRIAILPDGSLRIL---NASKSDEGKYVCRGENVFGSAEIIA 564
Query: 1282 EV-VEFPPKIVDYEREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKII---KKCKHTK 1335
+ V+ P +I + + G + L + A W + + I ++ H +
Sbjct: 565 SLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFE 624
Query: 1336 P-SIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDS 1394
+ SA L I+ + AG Y R++ E + + P PPG + EI
Sbjct: 625 SIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITE 684
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN----ITKTQTSIQNLKTNS--S 1448
S+ + W P +S I Y ++ + + W +VK IT S + N
Sbjct: 685 STATLSW-SPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 743
Query: 1449 YRFRAYAVNEVDISDAS------ETTEYYKVIKETKIQSPTVEKPLKNITTEP-NEDIEL 1501
Y FR A N + D S T E T + + + I EP +E+ +
Sbjct: 744 YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQN 803
Query: 1502 TCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
FG + + R G K K ++ ++ K +N+ G+
Sbjct: 804 GEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPF 862
Query: 1562 SCVVGI-QQKPVITISNEDIKQKHKVGDEWLVT--AVIEGIPPP---EVIWYKNGNKLEN 1615
S +V I + + + D+K E LV + E + P EV ++K+ +
Sbjct: 863 SQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME--QE 920
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKP-EGPVI 1674
D + T+ S + + L+ + +T+ A N AG + K S P + P
Sbjct: 921 DTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSN 980
Query: 1675 MR-EISRESVTIEWKP 1689
+R E V++ W+P
Sbjct: 981 LRWEQQGSQVSLGWEP 996
Score = 85.4 bits (202), Expect = 2e-15
Identities = 69/235 (29%), Positives = 107/235 (45%), Gaps = 19/235 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P + +K +D GS + EC+ P P WL G + P +S + M
Sbjct: 390 PHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP--------QSRVEMVNG 441
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLK-SMIVRQGESV 752
VL I NV + G Y +A N+ G LKI P + LK ++IV + + V
Sbjct: 442 VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKDQEV 499
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G+P+PTI+W K ++ V+ + S+ IL K DEG Y + EN G
Sbjct: 500 VIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK-SDEGKYVCRGENVFG 558
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
AE A ++V+EPT P + E+TV E +I L + + +T+Y
Sbjct: 559 SAEIIASLSVKEPTRIELTP-----KRTELTVGE--SIVLNCKAIHDASLDVTFY 606
Score = 83.4 bits (197), Expect = 8e-15
Identities = 110/464 (23%), Positives = 184/464 (39%), Gaps = 39/464 (8%)
Query: 645 VDEGSDILLECRLVA-IPEPDIAWLFKG-EEIVPDENISVAIESDMHMYCSVLKITNVKK 702
V EG ++L C PE +W+F V +++ + ++Y S ++ ++V
Sbjct: 207 VREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGS 266
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQGESVILSAQVVG 760
+ V R P+ L+ GE EP + ++ +G +V + +G
Sbjct: 267 YICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALG 326
Query: 761 NPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
NP PTITW K N P KA KS ++ + ++ D G+Y +AENS G
Sbjct: 327 NPVPTITWMKVNGYIPSKARLRKS----QAVLEIPNVQLDDAGIYECRAENSRGKNSFRG 382
Query: 819 VITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET 878
+ V P ++ + + + ++ + T P P+ W +N +SP
Sbjct: 383 QLQV-------YTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSR 435
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF-VKHLQKS 937
+ + N L+I NV ++ D+G Y+C+A N G A + I TF + L+K+
Sbjct: 436 V----EMVNGVLMIHNV-NQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKT 490
Query: 938 YETEEGKTVILEC--QTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVG 995
+ + V++EC Q S + W + + I+ +G D G
Sbjct: 491 IIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDG---SLRILNASKSDEG 547
Query: 996 VIKC----IVKDQETSTMLVVKE-TIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-- 1048
C + E L VKE T E K + V E V + I+ + DV
Sbjct: 548 KYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKA-IHDASLDVTFY 606
Query: 1049 WERDGEIIKPKKNKYDFEK---RGHIRKLYIRNTSVHDEGEYSC 1089
W G+ I ++ FE + L IRN + G Y C
Sbjct: 607 WTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGC 650
Score = 56.8 bits (131), Expect = 8e-07
Identities = 113/529 (21%), Positives = 201/529 (37%), Gaps = 55/529 (10%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSIT 790
+EP +I P S + V L+ +V GNP P+ W +N + + +
Sbjct: 103 QEPDDIIFPTDS----DEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFI 158
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE-ITVKE-KG 848
I P + KD G Y A N+ G I E T + A F R + ++V+E +G
Sbjct: 159 ISNPSEAKDSGHYQCLATNTVG------SILSREATLQFAYLGNFSGRTRSAVSVREGQG 212
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVA 908
+ + + +P +W N +E + E L I+ V + D G Y C+
Sbjct: 213 VVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTS-DVGSYICLV 271
Query: 909 SNSAGKS---SHGARVTIDVEKV------TFVKHLQKSYETEEGKTVILEC-QTSHTVST 958
N+ + S +T+ + V H + +G TV +EC + V T
Sbjct: 272 KNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT 331
Query: 959 -KWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTML---VVKE 1014
W +++G + D G+ +C ++ +
Sbjct: 332 ITW----MKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRK 1073
T P ++ KL D ++ E + + W ++G + P+ E +
Sbjct: 388 TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSR---VEMVNGV-- 442
Query: 1074 LYIRNTSVHDEGEYSCILRDE----SCTAEVTVVELPPEI-ITRLQNQ-KVNKGNKATFE 1127
L I N + D G Y C+ ++ +AE+ ++ P + +L+ V K + E
Sbjct: 443 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIE 502
Query: 1128 IE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCE----VGN 1182
+ + W K ++ + I + DG L+I + D G+Y C G+
Sbjct: 503 CKPQGSPKPTISWKKGDRAVRENKRIAILPDG---SLRILNASKSDEGKYVCRGENVFGS 559
Query: 1183 SKCTAILTVEEPS-INFTLRLPEFILVPANTDAYLTVEIPDETLDVTWY 1230
++ A L+V+EP+ I T + E L + I D +LDVT+Y
Sbjct: 560 AEIIASLSVKEPTRIELTPKRTE--LTVGESIVLNCKAIHDASLDVTFY 606
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 7/96 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +VEKL GS +++EC+ G PRP W + + P +M L+
Sbjct: 390 PHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVN-----GVLM 444
Query: 570 IREVFPEDAGTFTCVAKNAAG--FASSTTELIVEAP 603
I V DAG + C+A+N G +AS+ +++ AP
Sbjct: 445 IHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP 480
Score = 38.7 bits (86), Expect = 0.23
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV+ EC G P P ITW + I + + A L I V +DAG + C
Sbjct: 315 GTTVKMECFALGNPVPTITWMKVNGYIPSKARLR-----KSQAVLEIPNVQLDDAGIYEC 369
Query: 584 VAKNAAGFASSTTELIV 600
A+N+ G S +L V
Sbjct: 370 RAENSRGKNSFRGQLQV 386
Score = 35.9 bits (79), Expect = 1.6
Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 8/91 (8%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V EC+ +G P+P I+W + ++ ++ + D +L I D G + C +
Sbjct: 499 VVIECKPQGSPKPTISWKKGDRAVRENKRIAILPD----GSLRILNASKSDEGKYVCRGE 554
Query: 587 NAAGFASSTTELIVEAP----LSDHGSEMTV 613
N G A L V+ P L+ +E+TV
Sbjct: 555 NVFGSAEIIASLSVKEPTRIELTPKRTELTV 585
Score = 35.1 bits (77), Expect = 2.8
Identities = 23/90 (25%), Positives = 35/90 (38%), Gaps = 5/90 (5%)
Query: 504 EEQSMAPIFVEKLRPKHTP---DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
E P+FV++ P D V C+V G P P W R I D++
Sbjct: 93 ESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSL 152
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAG 590
D ++ +D+G + C+A N G
Sbjct: 153 IDGTF--IISNPSEAKDSGHYQCLATNTVG 180
>BC067101-1|AAH67101.1| 1212|Homo sapiens MYOM3 protein protein.
Length = 1212
Score = 107 bits (256), Expect = 6e-22
Identities = 132/533 (24%), Positives = 219/533 (41%), Gaps = 73/533 (13%)
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLE----NDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
L+T ++ PPP+V WYKN +++ +Y IT + I+ S+ YT+
Sbjct: 172 LLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDSATYTVR 231
Query: 1647 ASNTAGTSS--VEVTLKVY-DKPSKPEGPVIMREISRESV--TIEWKPPL--DDGGLELT 1699
N G +S +V ++ Y K + + + R SV T KP + L+
Sbjct: 232 VKNAHGQASSFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLS 291
Query: 1700 -KYAIEKHEPDNNRWI------------KVADVDRD--VETYCIQKLNENCEYMFRVIAQ 1744
++ + + ++ +W K+ DR ++ C K +E YM RV
Sbjct: 292 CLFSEDVLDAESIQWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGL-YMVRV--- 347
Query: 1745 NPVGFSEALESEPIVIKTA-LDVPSXXXXXXXXXXID--NESVYITWFPSEKNGGSPIID 1801
P F +S ++++ A + P +D + + +TW P G+PI
Sbjct: 348 -PSPFGPREQSTYVLVRDAEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITA 406
Query: 1802 YKVEIKQ-EGKKWKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTS---------- 1848
Y +E Q E +W R IQ L +Y+FR+ A + +G+S
Sbjct: 407 YTIERCQGESGEWIACHEAPGGTCRCPIQGLVEGQSYRFRVRAISRVGSSVPSKASELVV 466
Query: 1849 ------------LPYTSDDKITIGK-----TLTPPSQPRNFVVSESTSRSVTLKWTEPES 1891
+P+ +KITI T+T PS P N SE V L W EP
Sbjct: 467 MGDHDAARRKTEIPFDLGNKITISTDAFEDTVTIPSPPTNVHASEIREAYVVLAWEEPSP 526
Query: 1892 NGGSPITNYIIEFKTVKGKSWTKIVTVGG-SVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
G +P+T Y +E + +W I + + ++++K +FR+ A N G+S
Sbjct: 527 RGRAPLT-YSLEKSVIGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSD 585
Query: 1951 PTE-SQSVRLE-KHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDV 2008
P+E S+ + L AT+P PP R +++ +T W P D LLGY I R V
Sbjct: 586 PSEPSEPIALRGPPATLP-PPAQVQAFRDTQTSVSLT-W-DPVKD--PELLGYYIYSRKV 640
Query: 2009 TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
+ W V + +F + L Y + + +E G+ E + EP +V
Sbjct: 641 GTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVGESSAATEPIRV 693
Score = 83.8 bits (198), Expect = 6e-15
Identities = 80/332 (24%), Positives = 130/332 (39%), Gaps = 16/332 (4%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTS-----SVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+ +L++ S + + A N G S S + L+ P V ++ SV++
Sbjct: 562 VLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQTSVSLT 621
Query: 1687 WKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNP 1746
W P D EL Y I + + W V + + + L EY F V + +
Sbjct: 622 WDPVKDP---ELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSE 678
Query: 1747 VGFSEA-LESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE 1805
G E+ +EPI +K AL PS NE V I W P ++ GG I+ Y ++
Sbjct: 679 AGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEMV-IGWKPPKRRGGGKILGYFLD 737
Query: 1806 IKQ-EGKKWKXXXXXX--XXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK- 1861
E W ++ L Y+FR A N G +
Sbjct: 738 QHDSEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEW 797
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
T+ P P + SE + S+ L+W P G P+T Y + F+ + W K VT G
Sbjct: 798 TMPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQW-KPVTPGPI 856
Query: 1922 VHEHC-IENIKEKDEIIFRISAENTVGVSLPT 1952
H + +++ +F++ A N+ G+ P+
Sbjct: 857 SGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPS 888
Score = 71.3 bits (167), Expect = 3e-11
Identities = 65/276 (23%), Positives = 109/276 (39%), Gaps = 16/276 (5%)
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXA---RIQKLSINTTYQFRI 1839
V + W G +P+ Y +E G W+ + + L +Y FR+
Sbjct: 517 VVLAWEEPSPRGRAPLT-YSLEKSVIGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRV 575
Query: 1840 YARNEIGTSLPYTSDDKITIG---KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
A N+ G S P + I + TL PP+Q + F T SV+L W +P +
Sbjct: 576 RAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAF---RDTQTSVSLTW-DPVKD--PE 629
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES-Q 1955
+ Y I + V W + + ++ E F + + + GV + + +
Sbjct: 630 LLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVGESSAATE 689
Query: 1956 SVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWME 2015
+R+++ PS P + G N ++ W P+ GG +LGY + D + W
Sbjct: 690 PIRVKQALATPSAPYG-FALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHA 748
Query: 2016 VGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSE 2051
V + + T + DL E H Y R A N G+ E
Sbjct: 749 VNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGE 784
Score = 64.1 bits (149), Expect = 5e-09
Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 36/279 (12%)
Query: 1227 VTWYKKKSVIED----TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA--KSTTKLK 1280
VTWYK + I+ K+ + ++ +L IR+C +D YT + +A ++++ K
Sbjct: 185 VTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDSATYTVRVKNAHGQASSFAK 244
Query: 1281 VEVVEFPPKIVDYEREY---------------------RIKRGSDVTLLVDYQAFPQPND 1319
V V + K ++ E R K ++ L +
Sbjct: 245 VLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLSCLFSEDVLDAESI 304
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
+W + +++ + K + ASL + D G+Y +R+ + G + V + D
Sbjct: 305 QWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYMVRVPSPFGPREQSTYVLVRD 364
Query: 1380 ----KPSPPGKP-NI--LEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN 1432
P PG P N+ L+++ + + W P +T + I Y +E + ++ EWI+
Sbjct: 365 AEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWIACHE 424
Query: 1433 IT--KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ IQ L SYRFR A++ V S S+ +E
Sbjct: 425 APGGTCRCPIQGLVEGQSYRFRVRAISRVGSSVPSKASE 463
Score = 61.7 bits (143), Expect = 3e-08
Identities = 48/215 (22%), Positives = 81/215 (37%), Gaps = 6/215 (2%)
Query: 1649 NTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
++A T + V + PS P G ++ + + I WKPP GG ++ Y +++H+
Sbjct: 684 SSAATEPIRVK-QALATPSAPYGFALLN-CGKNEMVIGWKPPKRRGGGKILGYFLDQHDS 741
Query: 1709 DNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPS 1768
+ W V + L+E Y FR A N G E + +P
Sbjct: 742 EELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEWTMPQ 801
Query: 1769 -XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWK--XXXXXXXXXA 1824
+ S+ + W P G P+ Y V ++EG ++WK
Sbjct: 802 PGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISGTHL 861
Query: 1825 RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
R+ L +Y F++ A N G P D + +
Sbjct: 862 RVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLL 896
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 4/92 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
PSPP + EI + + + W+EP G + + Y +E I + W ++ + + +
Sbjct: 501 PSPPTNVHASEIREAYVVLAWEEPSPRGRAPLT-YSLEKSVIGSGTWEAISSESPVRSPR 559
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
++ +L+ SY FR A+N+ +SD SE +E
Sbjct: 560 FAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSE 591
Score = 48.0 bits (109), Expect = 4e-04
Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN---VA 566
P F LR + +TV C V+ P PQ+TW++ I P Y N +
Sbjct: 154 PWFWIPLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLL 213
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
+L IR ED+ T+T KNA G ASS +++V L
Sbjct: 214 SLEIRRCAIEDSATYTVRVKNAHGQASSFAKVLVRTYL 251
Score = 46.8 bits (106), Expect = 9e-04
Identities = 30/141 (21%), Positives = 67/141 (47%), Gaps = 11/141 (7%)
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMN---VTILDKPS---PPGKPNILEIDS 1394
+S + +E + ++++R N G +D + + P+ PP +
Sbjct: 556 RSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQ 615
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFR 1452
+S+++ WD ++ ++ Y + +++ T+EW +V N I T+ ++ L+T Y F
Sbjct: 616 TSVSLTWDPVKDP---ELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFC 672
Query: 1453 AYAVNEVDISDASETTEYYKV 1473
+V+E + ++S TE +V
Sbjct: 673 VRSVSEAGVGESSAATEPIRV 693
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/94 (24%), Positives = 45/94 (47%), Gaps = 2/94 (2%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITK 1435
+ +P PP E+ ++S+ + W+ P G + Y V +QE + +W ++ I+
Sbjct: 799 MPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISG 858
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
T + +L+ SY F+ A+N + S T+
Sbjct: 859 THLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTD 892
Score = 41.5 bits (93), Expect = 0.032
Identities = 37/167 (22%), Positives = 67/167 (40%), Gaps = 12/167 (7%)
Query: 1320 EW-IVNSKIIKKCKHTKPSIDS-KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
EW VN+K I+ + T P + + K ++ V G E++ + +
Sbjct: 644 EWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVG------ESSAATEPIRVKQA- 696
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITK 1435
L PS P +L + + I W P+ G I+ Y ++ + + +W +V I
Sbjct: 697 LATPSAPYGFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHAVNQQPIPT 756
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP 1482
+ +L Y FRA A N + + S + ++ KE + P
Sbjct: 757 RVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFE-CKEWTMPQP 802
Score = 37.9 bits (84), Expect = 0.39
Identities = 22/89 (24%), Positives = 47/89 (52%), Gaps = 6/89 (6%)
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD----GDTHSITILKPK 795
PL+S V + +V+L+ V +P P +TW KN+ + ++ + + + L+ +
Sbjct: 159 PLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIR 218
Query: 796 K--VKDEGVYTLKAENSEGIAETSAVITV 822
+ ++D YT++ +N+ G A + A + V
Sbjct: 219 RCAIEDSATYTVRVKNAHGQASSFAKVLV 247
Score = 37.5 bits (83), Expect = 0.52
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 9/97 (9%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP------SETITQNFDGE 886
P F + V E T+ L V +P P +TWY+N+ I P IT N+
Sbjct: 154 PWFWIPLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLL 213
Query: 887 NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
++E+ ++ DS Y N+ G++S A+V +
Sbjct: 214 SLEIRRCAIE---DSATYTVRVKNAHGQASSFAKVLV 247
>BC066363-1|AAH66363.1| 1805|Homo sapiens SDK2 protein protein.
Length = 1805
Score = 106 bits (255), Expect = 8e-22
Identities = 131/588 (22%), Positives = 220/588 (37%), Gaps = 33/588 (5%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA-----KATYENRXXX 1535
+P + + + T + L C G P+P +TW + + L + + T
Sbjct: 34 APNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSL 93
Query: 1536 XXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV 1595
Y C+A N G E S + + + IT +D Q G + +
Sbjct: 94 LISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQD--QSVIKGTQASMVCG 151
Query: 1596 IEGIPPPEV--IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT 1653
+ P + IW K+G L + I ++ + I + YT + G
Sbjct: 152 VTHDPRVTIRYIWEKDGATLGTESHPRIRL-DRNGSLHISQTWSGDIGTYTCRVISAGGN 210
Query: 1654 SSVEVTLKVYDKPSKPEGPV-IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR 1712
S L+V P PE PV + + R ++ + W P DG L +Y +E E +N
Sbjct: 211 DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPF-DGNSPLIRYILEMSE-NNAP 268
Query: 1713 W-IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXX 1771
W + +A VD + ++ L Y FR+ A N VG + + + + P+
Sbjct: 269 WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQ-FSKDTERVSLPEEPPTAPP 327
Query: 1772 XXXXXXXIDNESVYITWFP---SEKNG--GSPIIDYKVEIKQEGKKWKXXXXXXXXXARI 1826
N+S+ I W P S +NG II Y + G ++K +
Sbjct: 328 QNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLL 387
Query: 1827 QKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSEST-SRSVTLK 1885
+ L I T Y+ + A N G + Y+S K+T P+ P V +E+T S ++
Sbjct: 388 EDLIIWTNYEIEVAAYNSAGLGV-YSS--KVTEWTLQGVPTVPPGNVHAEATNSTTIRFT 444
Query: 1886 WTEPESNGGSPITN--YIIEFKTVKGKSWTKIV---TVGGSVHEHCIENIKEKDEIIFRI 1940
W P + I +I ++ + + T + S+H + +K+ E +
Sbjct: 445 WNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSV 504
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
T G + Q VR H VP P L + + SW P G L G
Sbjct: 505 LCFTTPGDGPRSTPQLVR--THEDVPG-PVGHLSFSEILDTSLKVSWQEPGEKNGI-LTG 560
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
Y I+ + +T + TL++ + L+ TY I + A G
Sbjct: 561 YRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKG 608
Score = 85.8 bits (203), Expect = 2e-15
Identities = 98/425 (23%), Positives = 175/425 (41%), Gaps = 50/425 (11%)
Query: 1658 VTLKVYDKPSKPEGPVIMRE-ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW-IK 1715
VT + D+P P P++ +E + SV + W+P DG + Y I+ E + RW +
Sbjct: 1025 VTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPG-SDGLSPVRYYTIQTRELPSGRWALH 1083
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXX 1775
A V + ++ + +L Y FRV A N +G SE E E + T P
Sbjct: 1084 SASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE-ESESLTTLQAAPDEAPTILS 1142
Query: 1776 XXXIDNESVYITWFP-SEKNGGSPIIDYKVE----------------IKQEGKKW----- 1813
SV I W P +E ++ +++ I G W
Sbjct: 1143 VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFMLRGINNPGATWAELTS 1202
Query: 1814 ----KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQP 1869
+ + L+ + Y+ R+ N +G P + ++ +G+ + P + P
Sbjct: 1203 MYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSSPPQEVFVGEAV-PTAAP 1260
Query: 1870 RNFVVSESTSRSVTLKWTEP--ESNGGSPITNYIIEF-KTVKGKSWTKIVTVGGSVHEHC 1926
RN VV +T+ + + W P +S G I Y I F + +G ++ T+ + +
Sbjct: 1261 RNVVVHGATATQLDVTWEPPPLDSQNGD-IQGYKIYFWEAQRGNLTERVKTLFLAENSVK 1319
Query: 1927 IENIKEKDEIIFRISAENTVG---VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++N+ + ++A N G S PT+ Q+ PS P++ ++ + + V
Sbjct: 1320 LKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQT-----QQAAPSAPSS-VKFSELTTTSV 1373
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM-EVGKVDV---NTLKFNIRDLSENHTYMI 2039
SW P++ G L GY + + + ++ VDV + L ++DL+E TY
Sbjct: 1374 NVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRF 1432
Query: 2040 RIYAR 2044
RI A+
Sbjct: 1433 RIRAK 1437
Score = 67.7 bits (158), Expect = 4e-10
Identities = 68/325 (20%), Positives = 137/325 (42%), Gaps = 16/325 (4%)
Query: 1171 DDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD 1226
DD G + C G + + L V + N T R P V L E
Sbjct: 6 DDTGMFQCFARNAAGEVQTSTYLAVTSIAPNIT-RGPLDSTVIDGMSVVLACETSGAPRP 64
Query: 1227 -VTWYKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV 1284
+TW K + ++ + + + ++ +L+I D YTC+ +++ + ++V
Sbjct: 65 AITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLV 124
Query: 1285 EFP-PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE--WIVNSKIIKKCKHTKPSIDSK 1341
+ +I ++ + +G+ +++ P+ W + + H + +D +
Sbjct: 125 VWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLD-R 183
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKP--NILEIDSSSINI 1399
+ SL I + + D G Y R+ + G+ ++ + P P P + ++ +IN+
Sbjct: 184 NGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINL 243
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSI--QNLKTNSSYRFRAYAVN 1457
W +P + GNS +I Y++E E + + + ++ TS+ + L SY+FR AVN
Sbjct: 244 TWTKPFD-GNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVN 302
Query: 1458 EVDISDASETTEYYKVIKETKIQSP 1482
+V S+ TE + +E P
Sbjct: 303 DVGKGQFSKDTERVSLPEEPPTAPP 327
Score = 67.7 bits (158), Expect = 4e-10
Identities = 91/414 (21%), Positives = 157/414 (37%), Gaps = 19/414 (4%)
Query: 1652 GTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNN 1711
G S ++ ++ P G + EI S+ + W+ P + G+ LT Y I E +
Sbjct: 513 GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRT 571
Query: 1712 RWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXX 1771
+ Y + L Y V A G + + + I ++P
Sbjct: 572 NTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTISSGVPPELPGPPT 630
Query: 1772 XXXXXXXIDNESVYITWFPSEKNGGSP---IIDYKVEIKQEGKKW----KXXXXXXXXXA 1824
I SV + + P S +++ +V + EG++W +
Sbjct: 631 NLGISN-IGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSM 689
Query: 1825 RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTL 1884
+ L+ T Y FR+ N +GTS P KI + P P N + ++ S+ L
Sbjct: 690 EVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQA-PPDMAPANVSLRTASETSLWL 748
Query: 1885 KW---TEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV-HEHCIENIKEKDEIIFRI 1940
+W E E NG Y I++ G T V V ++ IE+++E E ++
Sbjct: 749 RWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQV 808
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWG-TPEWDGGAPLL 1999
A N +G S P SQ+V +VPS + S+ ++ W PE D +L
Sbjct: 809 QAFNAIG-SGPW-SQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVL 866
Query: 2000 GYNIAIRDVTKTMWMEVGKVDVNTLK-FNIRDLSENHTYMIRIYARNEIGLSEP 2052
GY + ++ V+ N+ + + L + Y +++ A IG P
Sbjct: 867 GYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP 920
Score = 61.7 bits (143), Expect = 3e-08
Identities = 61/224 (27%), Positives = 96/224 (42%), Gaps = 19/224 (8%)
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPT 765
G + A N GE L + + P PL S ++ G SV+L+ + G PRP
Sbjct: 9 GMFQCFARNAAGEVQTSTYLAVTS--IAPNITRGPLDSTVI-DGMSVVLACETSGAPRPA 65
Query: 766 ITWCKNNKPVKA----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
ITW K + + + LP + ++ S+ ++ P + D G YT A NS G+ E SA +
Sbjct: 66 ITWQKGERILASGSVQLPRFTPLESGSL-LISPTHISDAGTYTCLATNSRGVDEASADLV 124
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI--TWYRNNEIISPSETI 879
V T +PP Q+ +V + +V VT +P +I W ++ +
Sbjct: 125 VWART-RITKPP------QDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHP 177
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
D N L I+ S D G Y C ++ G S A + +
Sbjct: 178 RIRLD-RNGSLHISQTWSG-DIGTYTCRVISAGGNDSRSAHLRV 219
Score = 60.9 bits (141), Expect = 5e-08
Identities = 33/120 (27%), Positives = 65/120 (54%), Gaps = 6/120 (5%)
Query: 1379 DKPSPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITK 1435
D+P PP +P + + D + S+ + W EP + G S + YY ++ +E+ + W + +++
Sbjct: 1031 DRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSH 1089
Query: 1436 TQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITT 1493
+S + LK +SY+FR A N++ S+ SE +E ++ ++PT+ + TT
Sbjct: 1090 NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTT 1149
Score = 60.1 bits (139), Expect = 9e-08
Identities = 86/392 (21%), Positives = 146/392 (37%), Gaps = 24/392 (6%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPE-GPVIMREISR--ESVTIEWK 1688
I++L+ + ++A N G+ T+ + S P GP + ++ S+ + W
Sbjct: 795 IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWS 854
Query: 1689 --PPLDDGGLELTKYAIEKHEPDNNR---WIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
P D GL L + K + + + W+ + R + + L + Y +V+A
Sbjct: 855 EVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQ---LTGLGKYVLYEVQVLA 911
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
+G + S P +++ LD + SV + W P G I+ Y+
Sbjct: 912 FTRIG--DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQ 968
Query: 1804 VEIKQEGKKWKXXXXXXXXXARIQK----LSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
+ + + Q L + Y FRI A+ G +T
Sbjct: 969 ITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWG-EAAEALVVTT 1027
Query: 1860 GKTLTPPSQPRNFVVSEST-SRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWT-KIVT 1917
K P R V E +RSV L W EP S+G SP+ Y I+ + + W +
Sbjct: 1028 EKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSAS 1086
Query: 1918 VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM 1977
V + ++ +K FR+ A N +G S +E A PT L +
Sbjct: 1087 VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI-LSVTP 1145
Query: 1978 VGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDV 2008
+ V+ W P D LLG+ I R++
Sbjct: 1146 HTTTSVLIRWQPPAEDKINGILLGFRIRYREL 1177
Score = 52.0 bits (119), Expect = 2e-05
Identities = 26/80 (32%), Positives = 40/80 (50%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
DG +V C+ G PRP ITW + I+ + +L+I DAGT+T
Sbjct: 48 DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYT 107
Query: 583 CVAKNAAGFASSTTELIVEA 602
C+A N+ G ++ +L+V A
Sbjct: 108 CLATNSRGVDEASADLVVWA 127
Score = 50.8 bits (116), Expect = 5e-05
Identities = 51/199 (25%), Positives = 83/199 (41%), Gaps = 16/199 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
I P ++ P V +G ++L C P P I W KGE I+ ++ + + +
Sbjct: 33 IAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLESG 91
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
++ T++ GTYT +A N G EAS +V+ +T +PPQ V +G
Sbjct: 92 SLLISPTHIS--DAGTYTCLATNSRGVDEASADLVVWARTRITKPPQ------DQSVIKG 143
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG----DTHSITILKPKKVKDEGVYTL 805
+ V +PR TI + K L T+S D + + D G YT
Sbjct: 144 TQASMVCGVTHDPRVTIRYIW-EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTC 202
Query: 806 KAENSEGIAETSAVITVEE 824
+ ++ G SA + V +
Sbjct: 203 RVISAGGNDSRSAHLRVRQ 221
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/126 (27%), Positives = 55/126 (43%), Gaps = 9/126 (7%)
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV---YDKPSKPEGPVIMREISRESVTIE 1686
+++K+L + ++ I A +E + P P P+I+R S ++ I
Sbjct: 1419 LKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSS--AIAIH 1476
Query: 1687 WKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQK--LNENCEYMFRVIA 1743
W D G +T+Y IE D W I + D+ ++V +Y L Y FRVIA
Sbjct: 1477 WSSG-DPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1535
Query: 1744 QNPVGF 1749
N GF
Sbjct: 1536 VNDYGF 1541
Score = 48.8 bits (111), Expect = 2e-04
Identities = 44/144 (30%), Positives = 67/144 (46%), Gaps = 13/144 (9%)
Query: 1337 SIDSKSASLTIKKVENTDAGI---YKLRLENNCGHADVEMNVTI---LDKPSPPGKPNIL 1390
++D K S KV++ G+ +++R + ++E NVT P PPG P I+
Sbjct: 1408 TVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIV 1467
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTS----IQNLKT 1445
SS+I I W + G I YV+E + D W I +K+I K +S + LK
Sbjct: 1468 RY-SSAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKP 1525
Query: 1446 NSSYRFRAYAVNEVDISDASETTE 1469
SY FR AVN+ S ++
Sbjct: 1526 GVSYDFRVIAVNDYGFGTPSSPSQ 1549
>AB040947-1|BAA96038.1| 1598|Homo sapiens KIAA1514 protein protein.
Length = 1598
Score = 106 bits (255), Expect = 8e-22
Identities = 131/588 (22%), Positives = 220/588 (37%), Gaps = 33/588 (5%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA-----KATYENRXXX 1535
+P + + + T + L C G P+P +TW + + L + + T
Sbjct: 78 APNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSL 137
Query: 1536 XXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV 1595
Y C+A N G E S + + + IT +D Q G + +
Sbjct: 138 LISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQD--QSVIKGTQASMVCG 195
Query: 1596 IEGIPPPEV--IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT 1653
+ P + IW K+G L + I ++ + I + YT + G
Sbjct: 196 VTHDPRVTIRYIWEKDGATLGTESHPRIRL-DRNGSLHISQTWSGDIGTYTCRVISAGGN 254
Query: 1654 SSVEVTLKVYDKPSKPEGPV-IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNR 1712
S L+V P PE PV + + R ++ + W P DG L +Y +E E +N
Sbjct: 255 DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPF-DGNSPLIRYILEMSE-NNAP 312
Query: 1713 W-IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXX 1771
W + +A VD + ++ L Y FR+ A N VG + + + + P+
Sbjct: 313 WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQ-FSKDTERVSLPEEPPTAPP 371
Query: 1772 XXXXXXXIDNESVYITWFP---SEKNG--GSPIIDYKVEIKQEGKKWKXXXXXXXXXARI 1826
N+S+ I W P S +NG II Y + G ++K +
Sbjct: 372 QNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLL 431
Query: 1827 QKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSEST-SRSVTLK 1885
+ L I T Y+ + A N G + Y+S K+T P+ P V +E+T S ++
Sbjct: 432 EDLIIWTNYEIEVAAYNSAGLGV-YSS--KVTEWTLQGVPTVPPGNVHAEATNSTTIRFT 488
Query: 1886 WTEPESNGGSPITN--YIIEFKTVKGKSWTKIV---TVGGSVHEHCIENIKEKDEIIFRI 1940
W P + I +I ++ + + T + S+H + +K+ E +
Sbjct: 489 WNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSV 548
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLG 2000
T G + Q VR H VP P L + + SW P G L G
Sbjct: 549 LCFTTPGDGPRSTPQLVR--THEDVPG-PVGHLSFSEILDTSLKVSWQEPGEKNGI-LTG 604
Query: 2001 YNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
Y I+ + +T + TL++ + L+ TY I + A G
Sbjct: 605 YRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKG 652
Score = 85.8 bits (203), Expect = 2e-15
Identities = 98/425 (23%), Positives = 175/425 (41%), Gaps = 50/425 (11%)
Query: 1658 VTLKVYDKPSKPEGPVIMRE-ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW-IK 1715
VT + D+P P P++ +E + SV + W+P DG + Y I+ E + RW +
Sbjct: 1069 VTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPG-SDGLSPVRYYTIQTRELPSGRWALH 1127
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXX 1775
A V + ++ + +L Y FRV A N +G SE E E + T P
Sbjct: 1128 SASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE-ESESLTTLQAAPDEAPTILS 1186
Query: 1776 XXXIDNESVYITWFP-SEKNGGSPIIDYKVE----------------IKQEGKKW----- 1813
SV I W P +E ++ +++ I G W
Sbjct: 1187 VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTS 1246
Query: 1814 ----KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQP 1869
+ + L+ + Y+ R+ N +G P + ++ +G+ + P + P
Sbjct: 1247 MYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSSPPQEVFVGEAV-PTAAP 1304
Query: 1870 RNFVVSESTSRSVTLKWTEP--ESNGGSPITNYIIEF-KTVKGKSWTKIVTVGGSVHEHC 1926
RN VV +T+ + + W P +S G I Y I F + +G ++ T+ + +
Sbjct: 1305 RNVVVHGATATQLDVTWEPPPLDSQNGD-IQGYKIYFWEAQRGNLTERVKTLFLAENSVK 1363
Query: 1927 IENIKEKDEIIFRISAENTVG---VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++N+ + ++A N G S PT+ Q+ PS P++ ++ + + V
Sbjct: 1364 LKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQT-----QQAAPSAPSS-VKFSELTTTSV 1417
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM-EVGKVDV---NTLKFNIRDLSENHTYMI 2039
SW P++ G L GY + + + ++ VDV + L ++DL+E TY
Sbjct: 1418 NVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRF 1476
Query: 2040 RIYAR 2044
RI A+
Sbjct: 1477 RIRAK 1481
Score = 77.8 bits (183), Expect = 4e-13
Identities = 105/507 (20%), Positives = 189/507 (37%), Gaps = 32/507 (6%)
Query: 1499 IELTCIFGGVPQPKVTWYRDGKKLKTAKAT---YENRXXXXXXXXXXXXXXXYKCIAFND 1555
+++ C GVP P +TWY+D ++ K T N ++C A N
Sbjct: 3 VDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNA 62
Query: 1556 HGEVETSCVVGIQQ-KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE 1614
GEV+TS + + P IT D G ++ G P P + W K L
Sbjct: 63 AGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSVVLACETSGAPRPAITWQKGERILA 120
Query: 1615 NDKEY--NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+ T E S++ I S + YT A+N+ G L V+ + + P
Sbjct: 121 SGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPP 179
Query: 1673 VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPD-NNRWIKVADVDRDVETYCIQKL 1731
I ++ D +Y EK +DR+ + Q
Sbjct: 180 QDQSVIKGTQASMVCGVTHDP--RVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTW 237
Query: 1732 NENC-EYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP 1790
+ + Y RVI+ G +++ S + ++ P ++ ++ +TW
Sbjct: 238 SGDIGTYTCRVIS---AGGNDS-RSAHLRVRQLPHAPE--HPVATLSTVERRAINLTW-T 290
Query: 1791 SEKNGGSPIIDYKVEIKQEGKKWKXXXXX---XXXXARIQKLSINTTYQFRIYARNEIGT 1847
+G SP+I Y +E+ + W ++ L +YQFR+ A N++G
Sbjct: 291 KPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGK 350
Query: 1848 SLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKW-TEPESNGGSPITNYIIEFKT 1906
+++++ + P + P+N + S T++S+ ++W PES+ + YII +
Sbjct: 351 GQFSKDTERVSLPEE-PPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCL 409
Query: 1907 V---KGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHA 1963
G + I V+ +E++ ++A N+ G L S V
Sbjct: 410 AGLPVGYQFKNI--TDADVNNLLLEDLIIWTNYEIEVAAYNSAG--LGVYSSKVTEWTLQ 465
Query: 1964 TVPSPPTAPLEIRMVGSNIVMTSWGTP 1990
VP+ P + S + +W P
Sbjct: 466 GVPTVPPGNVHAEATNSTTIRFTWNAP 492
Score = 71.3 bits (167), Expect = 3e-11
Identities = 76/361 (21%), Positives = 152/361 (42%), Gaps = 21/361 (5%)
Query: 1137 VRWFKDGS--EIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILT 1190
+ W+KD + E++ + DG L+I DD G + C G + + L
Sbjct: 17 ITWYKDAAVVEVEKLTRFRQRNDGG---LQISGLVPDDTGMFQCFARNAAGEVQTSTYLA 73
Query: 1191 VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIED-TEKFTLISDV 1248
V + N T R P V L E +TW K + ++ + + + +
Sbjct: 74 VTSIAPNIT-RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPL 132
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYEREYRIKRGSDVTL 1307
+ +L+I D YTC+ +++ + ++V + +I ++ + +G+ ++
Sbjct: 133 ESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASM 192
Query: 1308 LVDYQAFPQPNDE--WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENN 1365
+ P+ W + + H + +D ++ SL I + + D G Y R+ +
Sbjct: 193 VCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLD-RNGSLHISQTWSGDIGTYTCRVISA 251
Query: 1366 CGHADVEMNVTILDKPSPPGKP--NILEIDSSSINICWDEPENTGNSTIIYYVVEYQEID 1423
G+ ++ + P P P + ++ +IN+ W +P + GNS +I Y++E E +
Sbjct: 252 GGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENN 310
Query: 1424 TTEWISVKNITKTQTSI--QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQS 1481
+ + ++ TS+ + L SY+FR AVN+V S+ TE + +E
Sbjct: 311 APWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAP 370
Query: 1482 P 1482
P
Sbjct: 371 P 371
Score = 69.3 bits (162), Expect = 1e-10
Identities = 71/277 (25%), Positives = 118/277 (42%), Gaps = 24/277 (8%)
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
+ C+ +P P I W +K +V E ++ + + L+I+ + G + A
Sbjct: 5 IPCQAKGVPPPSITW-YKDAAVVEVEKLTRFRQRND----GGLQISGLVPDDTGMFQCFA 59
Query: 713 VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN 772
N GE L + + P PL S ++ G SV+L+ + G PRP ITW K
Sbjct: 60 RNAAGEVQTSTYLAVTS--IAPNITRGPLDSTVI-DGMSVVLACETSGAPRPAITWQKGE 116
Query: 773 KPVKA----LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
+ + + LP + ++ S+ ++ P + D G YT A NS G+ E SA + V T
Sbjct: 117 RILASGSVQLPRFTPLESGSL-LISPTHISDAGTYTCLATNSRGVDEASADLVVWART-R 174
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI--TWYRNNEIISPSETITQNFDGE 886
+PP Q+ +V + +V VT +P +I W ++ + D
Sbjct: 175 ITKPP------QDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLD-R 227
Query: 887 NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
N L I+ S D G Y C ++ G S A + +
Sbjct: 228 NGSLHISQTWSG-DIGTYTCRVISAGGNDSRSAHLRV 263
Score = 67.7 bits (158), Expect = 4e-10
Identities = 91/414 (21%), Positives = 157/414 (37%), Gaps = 19/414 (4%)
Query: 1652 GTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNN 1711
G S ++ ++ P G + EI S+ + W+ P + G+ LT Y I E +
Sbjct: 557 GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRT 615
Query: 1712 RWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXX 1771
+ Y + L Y V A G + + + I ++P
Sbjct: 616 NTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTISSGVPPELPGPPT 674
Query: 1772 XXXXXXXIDNESVYITWFPSEKNGGSP---IIDYKVEIKQEGKKW----KXXXXXXXXXA 1824
I SV + + P S +++ +V + EG++W +
Sbjct: 675 NLGISN-IGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSM 733
Query: 1825 RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTL 1884
+ L+ T Y FR+ N +GTS P KI + P P N + ++ S+ L
Sbjct: 734 EVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQA-PPDMAPANVSLRTASETSLWL 792
Query: 1885 KW---TEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV-HEHCIENIKEKDEIIFRI 1940
+W E E NG Y I++ G T V V ++ IE+++E E ++
Sbjct: 793 RWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQV 852
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWG-TPEWDGGAPLL 1999
A N +G S P SQ+V +VPS + S+ ++ W PE D +L
Sbjct: 853 QAFNAIG-SGPW-SQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVL 910
Query: 2000 GYNIAIRDVTKTMWMEVGKVDVNTLK-FNIRDLSENHTYMIRIYARNEIGLSEP 2052
GY + ++ V+ N+ + + L + Y +++ A IG P
Sbjct: 911 GYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP 964
Score = 60.9 bits (141), Expect = 5e-08
Identities = 33/120 (27%), Positives = 65/120 (54%), Gaps = 6/120 (5%)
Query: 1379 DKPSPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITK 1435
D+P PP +P + + D + S+ + W EP + G S + YY ++ +E+ + W + +++
Sbjct: 1075 DRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSH 1133
Query: 1436 TQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITT 1493
+S + LK +SY+FR A N++ S+ SE +E ++ ++PT+ + TT
Sbjct: 1134 NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTT 1193
Score = 60.1 bits (139), Expect = 9e-08
Identities = 86/392 (21%), Positives = 146/392 (37%), Gaps = 24/392 (6%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPE-GPVIMREISR--ESVTIEWK 1688
I++L+ + ++A N G+ T+ + S P GP + ++ S+ + W
Sbjct: 839 IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWS 898
Query: 1689 --PPLDDGGLELTKYAIEKHEPDNNR---WIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
P D GL L + K + + + W+ + R + + L + Y +V+A
Sbjct: 899 EVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQ---LTGLGKYVLYEVQVLA 955
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
+G + S P +++ LD + SV + W P G I+ Y+
Sbjct: 956 FTRIG--DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQ 1012
Query: 1804 VEIKQEGKKWKXXXXXXXXXARIQK----LSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
+ + + Q L + Y FRI A+ G +T
Sbjct: 1013 ITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWG-EAAEALVVTT 1071
Query: 1860 GKTLTPPSQPRNFVVSEST-SRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWT-KIVT 1917
K P R V E +RSV L W EP S+G SP+ Y I+ + + W +
Sbjct: 1072 EKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSAS 1130
Query: 1918 VGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRM 1977
V + ++ +K FR+ A N +G S +E A PT L +
Sbjct: 1131 VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI-LSVTP 1189
Query: 1978 VGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDV 2008
+ V+ W P D LLG+ I R++
Sbjct: 1190 HTTTSVLIRWQPPAEDKINGILLGFRIRYREL 1221
Score = 53.6 bits (123), Expect = 7e-06
Identities = 26/74 (35%), Positives = 40/74 (54%), Gaps = 2/74 (2%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V CQ +G P P ITW++ A+++ + + +D L I + P+D G F C A+
Sbjct: 3 VDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG--GLQISGLVPDDTGMFQCFAR 60
Query: 587 NAAGFASSTTELIV 600
NAAG ++T L V
Sbjct: 61 NAAGEVQTSTYLAV 74
Score = 52.0 bits (119), Expect = 2e-05
Identities = 26/80 (32%), Positives = 40/80 (50%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
DG +V C+ G PRP ITW + I+ + +L+I DAGT+T
Sbjct: 92 DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYT 151
Query: 583 CVAKNAAGFASSTTELIVEA 602
C+A N+ G ++ +L+V A
Sbjct: 152 CLATNSRGVDEASADLVVWA 171
Score = 51.6 bits (118), Expect = 3e-05
Identities = 57/258 (22%), Positives = 98/258 (37%), Gaps = 20/258 (7%)
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKA-----LPTKSDGDTHSITILKPKKVKDEGVYTLK 806
V + Q G P P+ITW K+ V+ ++DG I+ L P D G++
Sbjct: 3 VDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGL-QISGLVP---DDTGMFQCF 58
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
A N+ G +TS + V PL + TV + ++ L + P P+ITW
Sbjct: 59 ARNAAGEVQTSTYLAVTSIAPNITRGPL------DSTVIDGMSVVLACETSGAPRPAITW 112
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
+ I++ F ++ + D+G Y C+A+NS G A + +
Sbjct: 113 QKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWAR 172
Query: 927 KVTFVKHLQKSYETEEGKTVILECQTSH--TVSTKWYHNKKEIS-GMDHREIIQEGRXXX 983
T + + +G + C +H V+ ++ K + G + I+ R
Sbjct: 173 --TRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGS 230
Query: 984 XXXXXXXXXDVGVIKCIV 1001
D+G C V
Sbjct: 231 LHISQTWSGDIGTYTCRV 248
Score = 50.8 bits (116), Expect = 5e-05
Identities = 51/199 (25%), Positives = 83/199 (41%), Gaps = 16/199 (8%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
I P ++ P V +G ++L C P P I W KGE I+ ++ + + +
Sbjct: 77 IAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLESG 135
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
++ T++ GTYT +A N G EAS +V+ +T +PPQ V +G
Sbjct: 136 SLLISPTHIS--DAGTYTCLATNSRGVDEASADLVVWARTRITKPPQ------DQSVIKG 187
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG----DTHSITILKPKKVKDEGVYTL 805
+ V +PR TI + K L T+S D + + D G YT
Sbjct: 188 TQASMVCGVTHDPRVTIRYIW-EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTC 246
Query: 806 KAENSEGIAETSAVITVEE 824
+ ++ G SA + V +
Sbjct: 247 RVISAGGNDSRSAHLRVRQ 265
>U40317-1|AAC50567.1| 1911|Homo sapiens PTPsigma protein.
Length = 1911
Score = 106 bits (254), Expect = 1e-21
Identities = 125/591 (21%), Positives = 222/591 (37%), Gaps = 38/591 (6%)
Query: 1473 VIKETKIQS--PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD----GKKLKTAK 1526
V++E ++ S P ++ + E + C G P P++TW++D +
Sbjct: 124 VLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGR 183
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV 1586
Y+C+A N G +S + + + H++
Sbjct: 184 IKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEI 243
Query: 1587 --GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
G +T V G P P V W + L + + + +V+ + ++K S ++ +
Sbjct: 244 MPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPV----GRNVLELTDVKDS-ANYHP 298
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
A ++ G + V P P P++ E + S+TI W D G + Y +
Sbjct: 299 CVAMSSLGVIEAVAQITVKSLPKAPGTPMV-TENTATSITITW----DSGNPDPVSYYVI 353
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTAL 1764
+++ + D Y I L+ N EY V A N +G + SE +V +T
Sbjct: 354 EYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG--QGPPSESVVTRTGE 411
Query: 1765 DVPSXXXXXXXXXXIDNESVYITW-FPSEKNG--GSPIIDYKVEIKQEGKKWKXXXXXXX 1821
P+ + ++ + W P E NG + Y +E + W+
Sbjct: 412 QAPARPPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDS 471
Query: 1822 XXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS 1881
+ L + TY R+ A +G P + D I + P QP N + S
Sbjct: 472 LLTTVGSLLEDETYTVRVLAFTSVGDG-PLS--DPIQVKTQQGVPGQPMNLRAEARSETS 528
Query: 1882 VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRIS 1941
+TL W+ P I Y + F+ +G ++ + +E++K E FR++
Sbjct: 529 ITLSWSPPRQES---IIKYELLFR--EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLA 583
Query: 1942 AENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSW--GTPEWDGGAPLL 1999
A + G+ T VR + PS P ++ V S ++ SW PE GA L+
Sbjct: 584 ARSPQGLGAFT--PVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGA-LV 640
Query: 2000 GYNIAIRDV--TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
GY++ R + EV + T + + L + Y I A E+G
Sbjct: 641 GYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVG 691
Score = 95.9 bits (228), Expect = 1e-18
Identities = 190/953 (19%), Positives = 351/953 (36%), Gaps = 81/953 (8%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQ 1161
E PP I ++Q G A+F + T GD R W K G ++ + D
Sbjct: 30 EEPPRFIKEPKDQIGVSGRVASFVCQAT-GDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 1162 K-LKIYDCDLD-DAGEYSCEVGNS--------KCTAILTVEEPSINFTLRL-PEFILVP- 1209
L+I D Y C NS K T + + PS + + P+ +V
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
T L + ++TW+K ++ + I ++ L I E DQ +Y CV
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 208
Query: 1270 LLDA-----KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
++ S L V V P+ + I G +V + P P +W+
Sbjct: 209 ATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQG 268
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLE-NNCGHADVEMNVTILDKPSP 1383
++ + P D ++ + D+ Y + ++ G + +T+ P
Sbjct: 269 AEDLT------PEDDMPVGRNVLELTDVKDSANYHPCVAMSSLGVIEAVAQITVKSLPKA 322
Query: 1384 PGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWISVK-NITKTQTSIQ 1441
PG P + E ++SI I WD +GN + YYV+EY+ +K +IT T+ SI
Sbjct: 323 PGTPMVTENTATSITITWD----SGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIG 378
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP-----TVEKPLKNITT--- 1493
L NS Y AVN + SE+ V+ T Q+P V+ + + TT
Sbjct: 379 GLSPNSEYEIWVSAVNSIGQGPPSES-----VVTRTGEQAPARPPRNVQARMLSATTMIV 433
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAF 1553
+ E +E + G + T + K ++ + +AF
Sbjct: 434 QWEEPVEPNGLIRGY-RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAF 492
Query: 1554 NDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPE--VIWYK-NG 1610
G+ S IQ K + + + + + E +T + PP + +I Y+
Sbjct: 493 TSVGDGPLS--DPIQVKTQQGVPGQPMNLRAEARSETSIT--LSWSPPRQESIIKYELLF 548
Query: 1611 NKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK---VYDKPS 1667
+ ++ +E T TS + +++LK + + + A + G + ++ + KPS
Sbjct: 549 REGDHGREVGRTFDPTTSYV-VEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPS 607
Query: 1668 KPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEP---DNNRWIKVADVDRDV 1723
P V + ++ + W+ PP + L Y++ ++ P ++ +V +
Sbjct: 608 APPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSV-RYRPLGSEDPEPKEVNGIPPTT 666
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNES 1783
++ L + +Y +A VG ES P+V++T DVPS ++ +
Sbjct: 667 TQILLEALEKWTQYRITTVAHTEVG--PGPESSPVVVRTDEDVPSAPPRKVEAEALNATA 724
Query: 1784 VYITW-FPSEKNGGSPIIDYKVEI----KQEGKKWKXXXXXXXXXAR---IQKLSINTTY 1835
+ + W P+ I Y+V ++E + + A+ I L T Y
Sbjct: 725 IRVLWRSPAPGRQHGQIRGYQVHYVRMERREARGRRSIKDVMLADAQEMVITNLQPETAY 784
Query: 1836 QFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGS 1895
+ A G +T G L P+ V ++ S+ +W P
Sbjct: 785 SITVAAYTMKGDGARSKPKVVVTKGAVLGRPT----LSVQQTPEGSLLARWEPPAGTAED 840
Query: 1896 PITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQ 1955
+ Y ++F + + + S + + + +FR++A + G L E+
Sbjct: 841 QVLGYRLQFGR-EDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSPGG--LGEEAA 897
Query: 1956 SVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP-EWDGGAPLLGYNIAIRD 2007
V T P + V+ W P + ++ Y +A+R+
Sbjct: 898 EVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVRE 950
Score = 83.4 bits (197), Expect = 8e-15
Identities = 72/264 (27%), Positives = 117/264 (44%), Gaps = 10/264 (3%)
Query: 717 GEASLPIVLKIK-TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
G L +VL + +EPP+ I+ K I G Q G+P+P +TW K K V
Sbjct: 14 GPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGRVASFVCQATGDPKPRVTWNKKGKKV 73
Query: 776 KALPTKS---DGDTHSITILKPKKV-KDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ ++ D ++ ++P + +DE VY A+NS G A +TV + +
Sbjct: 74 NSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSG 133
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELV 891
P Q V+ T ++ + NP P ITW+++ + PS + + + L
Sbjct: 134 FPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQ 193
Query: 892 ITNVDSEIDSGDYKCVASNSAG-KSSHGARVTIDVEKVT-FVKHLQKSYETEEGKTVILE 949
I + E D G Y+CVA+NSAG + S A + + V +V L S+E G V +
Sbjct: 194 IES-SEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNIT 252
Query: 950 CQT--SHTVSTKWYHNKKEISGMD 971
C S KW ++++ D
Sbjct: 253 CVAVGSPMPYVKWMQGAEDLTPED 276
Score = 75.4 bits (177), Expect = 2e-12
Identities = 75/300 (25%), Positives = 127/300 (42%), Gaps = 24/300 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F K+PK Q G C+ P+P + W KG+++ + IE D
Sbjct: 32 PPRFIKEPKDQIGVSGRVASFVCQATGDPKPRVTWNKKGKKV--NSQRFETIEFD-ESAG 88
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
+VL+I ++ E Y VA N GE ++ L + ++ P P + + +V +
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYT 804
+ + GNP P ITW K+ PV P+ S+G + ++ + D+G Y
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVD--PSASNGRIKQLRSGALQIESSEETDQGKYE 206
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
A NS G+ +S P F + G + + +P+P +
Sbjct: 207 CVATNSAGVRYSSPANLY---VRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYV 263
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDY-KCVASNSAGKSSHGARVTI 923
W + E ++P + + G N+ L +T+V DS +Y CVA +S G A++T+
Sbjct: 264 KWMQGAEDLTPEDDMPV---GRNV-LELTDVK---DSANYHPCVAMSSLGVIEAVAQITV 316
Score = 74.5 bits (175), Expect = 4e-12
Identities = 81/338 (23%), Positives = 139/338 (41%), Gaps = 35/338 (10%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++ + + G F CQ G P+P++TW ++ + + + +D+ A L
Sbjct: 33 PRFIKEPKDQIGVSGRVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 570 IREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I+ + P D + CVA+N+ G E+ V A L+ D
Sbjct: 93 IQPLRTPRDENVYECVAQNSVG------EITVHAKLT-----------------VLREDQ 129
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
L P P+ + V+ + C P+P+I W FK + +P + S +
Sbjct: 130 LPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITW-FK--DFLPVDP-SASNGRIK 185
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREG-EASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ L+I + ++ +G Y VA N G S P L ++ P I P+ I+
Sbjct: 186 QLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIM- 244
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVY-TLK 806
G +V ++ VG+P P + W + + + T D +L+ VKD Y
Sbjct: 245 PGGNVNITCVAVGSPMPYVKWMQGAEDL----TPEDDMPVGRNVLELTDVKDSANYHPCV 300
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITV 844
A +S G+ E A ITV+ + P + N IT+
Sbjct: 301 AMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI 338
Score = 62.9 bits (146), Expect = 1e-08
Identities = 88/429 (20%), Positives = 168/429 (39%), Gaps = 39/429 (9%)
Query: 1643 YTIE--ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRE--SVTIEWKPPLDDGGLEL 1698
YT+ A + G + ++V + P P+ +R +R S+T+ W PP + +
Sbjct: 485 YTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQES---I 541
Query: 1699 TKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
KY + E D+ R +V +Y ++ L N EY FR+ A++P G P+
Sbjct: 542 IKYELLFREGDHGR--EVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG---AFTPV 596
Query: 1759 V-IKTALDVPSXXXXXXXXXXIDNESVYITWF--PSEKNGGSPIIDYKVEIKQEGK---- 1811
V +T PS + + ++ ++W P E + G+ ++ Y V + G
Sbjct: 597 VRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGA-LVGYSVRYRPLGSEDPE 655
Query: 1812 -KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR 1870
K ++ L T Y+ A E+G P +S + + + P + PR
Sbjct: 656 PKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPG-PESSPVVVRTDEDV-PSAPPR 713
Query: 1871 NFVVSESTSRSVTLKWTEP---ESNG---GSPITNYIIEFKTVKGKSWTKIVTVGGSVHE 1924
+ ++ + W P +G G + +E + +G+ K V + E
Sbjct: 714 KVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMERREARGRRSIKDVML-ADAQE 772
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVM 1984
I N++ + ++A G ++ + V + K A + P L ++ ++
Sbjct: 773 MVITNLQPETAYSITVAAYTMKGDGARSKPKVV-VTKGAVLGRP---TLSVQQTPEGSLL 828
Query: 1985 TSWGTPEWDGGAPLLGYNIAI--RDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
W P +LGY + D T +E + ++ + + TY+ R+
Sbjct: 829 ARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSED---RYTASGVHKGATYVFRLA 885
Query: 2043 ARNEIGLSE 2051
AR+ GL E
Sbjct: 886 ARSPGGLGE 894
Score = 46.0 bits (104), Expect = 0.001
Identities = 57/252 (22%), Positives = 100/252 (39%), Gaps = 27/252 (10%)
Query: 1682 SVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRV 1741
S+ W+PP ++ Y ++ D+ + + + Y +++ Y+FR+
Sbjct: 826 SLLARWEPPAGTAEDQVLGYRLQFGREDSTP-LATLEFPPSEDRYTASGVHKGATYVFRL 884
Query: 1742 IAQNPVGFSE-ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGS 1797
A++P G E A E I T P +V + W P +E+NG
Sbjct: 885 AARSPGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASA---GTVLLRWLPPVPAERNGA- 940
Query: 1798 PIIDYKVEIKQEG-----KKWKXXXXXXXXXAR---IQKLSINTTYQFRIYARNEIGTSL 1849
I+ Y V +++ G ++ + R +Q L +T Y ++ A G
Sbjct: 941 -IVKYTVAVREAGALGPARETELPAGRLSRARRTLTLQGLKPDTAYDLQVRAHTRRGPG- 998
Query: 1850 PYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK---- 1905
P++ + L P+NF V SV L W P+ N SP T Y I++
Sbjct: 999 PFSPP--VRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPD-NYNSP-TPYKIQYNGLTL 1054
Query: 1906 TVKGKSWTKIVT 1917
V G++ K++T
Sbjct: 1055 DVDGRTTKKLIT 1066
>AY424269-1|AAR29061.1| 1845|Homo sapiens myosin light chain
polypeptide kinase isoform 2 protein.
Length = 1845
Score = 105 bits (251), Expect = 2e-21
Identities = 73/246 (29%), Positives = 105/246 (42%), Gaps = 12/246 (4%)
Query: 487 KLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
K + +D V P +E AP F+ R +G+T +FE +V GYP PQ+TW R
Sbjct: 14 KTSLSVDPSRVDSMPLTE----APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRN 69
Query: 547 TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I F + +LVI V ED G +TC A N +G T EL VE +
Sbjct: 70 GQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAK 129
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGI----PPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ V + I PP F+ K V EG C++ P+
Sbjct: 130 QLGQPVVSKTLGDRFSASAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQ 189
Query: 663 PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLP 722
P + WL + P +SV+ ++ M VL+I V + G YT + VN G+AS+
Sbjct: 190 PQVTWLKGNVPLQPSARVSVSEKNGM----QVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 723 IVLKIK 728
L I+
Sbjct: 246 AELSIQ 251
Score = 101 bits (243), Expect = 2e-20
Identities = 75/303 (24%), Positives = 130/303 (42%), Gaps = 28/303 (9%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+FS K V EG D +L+C + P P I WL G+ I + A +++H
Sbjct: 443 VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELH-- 500
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASL---------------PIVLKIKTGEKEPPQ 736
I + GTYT +A N G+ S +L + + P
Sbjct: 501 -----IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPI 555
Query: 737 VIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILK 793
++ L + V G V ++ QV GNP P + W N ++ + G HS+ I +
Sbjct: 556 FLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCI-Q 614
Query: 794 PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLV 853
+D G YT +A NS G T AV+TV+EP + P FI++ + +T ++ +
Sbjct: 615 EVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP--HDGTQPWFISKPRSVTASLGQSVLIS 672
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+ +P P++ W R+ + + + E++ ++ +G Y+ + N G
Sbjct: 673 CAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVG 732
Query: 914 KSS 916
+ S
Sbjct: 733 ECS 735
Score = 101 bits (241), Expect = 4e-20
Identities = 75/267 (28%), Positives = 114/267 (42%), Gaps = 20/267 (7%)
Query: 508 MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
+AP F L+ +G +C V G P P+ITW +P Q + + VA
Sbjct: 443 VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNG---QPIQ-YARSTCEAGVAE 498
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
L I++ PED GT+TC+A+NA G S + + V S SE +
Sbjct: 499 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPS--------- 549
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ P F + V +GS + + ++ P P++ WL G EI E+
Sbjct: 550 --KPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGT 607
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI-KTGEKEPPQVIEPLKSMIV 746
H C I V GTYT A N GE VL + + + P I +S+
Sbjct: 608 QHSLC----IQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTA 663
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNK 773
G+SV++S + G+P PT+ W ++ K
Sbjct: 664 SLGQSVLISCAIAGDPFPTVHWLRDGK 690
Score = 96.3 bits (229), Expect = 1e-18
Identities = 53/200 (26%), Positives = 90/200 (45%), Gaps = 1/200 (0%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP+I+ + + +++ G V L W+ K I++ +H K + LT
Sbjct: 1168 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLT 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDEPE 1405
I G Y L +EN G ++N+T++DKP PP G P +I SSS+ + W
Sbjct: 1228 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1287
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G S + Y +E + W + T ++Q+L + Y+FR A+N S+ S
Sbjct: 1288 YDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPS 1347
Query: 1466 ETTEYYKVIKETKIQSPTVE 1485
+ +E V ++ + VE
Sbjct: 1348 QESELTTVGEKPEEPKDEVE 1367
Score = 95.5 bits (227), Expect = 2e-18
Identities = 69/241 (28%), Positives = 109/241 (45%), Gaps = 30/241 (12%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P + + APIF++ L DGS V QV G P P++ W I+ S+DF +
Sbjct: 545 PVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH-FE 603
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
+L I+EVFPED GT+TC A N+AG + L V+ P H
Sbjct: 604 QRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP---H------------- 647
Query: 621 XXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI 680
+G P F KP++ G +L+ C + P P + WL G+ + D
Sbjct: 648 ---------DGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGH 698
Query: 681 SVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK-TGEKEPPQVIE 739
++++ ++ VLK V+ + G Y ++ NR GE S + L ++ + + P+ E
Sbjct: 699 FEVLQNE-DVFTLVLK--KVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGRE 755
Query: 740 P 740
P
Sbjct: 756 P 756
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 1715 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 1774
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 1775 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1831
Score = 85.8 bits (203), Expect = 2e-15
Identities = 69/262 (26%), Positives = 111/262 (42%), Gaps = 22/262 (8%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P LK V +G+ +L V G P P ITW N +P++ + + + I +
Sbjct: 445 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHI-QD 503
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN----------AEP--PLFINRFQEI 842
+D G YT AEN+ G SA +TV E ++P P+F+ ++
Sbjct: 504 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 563
Query: 843 TVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSG 902
V + + + +V+ NP P + W N I SE G L I V E D+G
Sbjct: 564 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPE-DTG 622
Query: 903 DYKCVASNSAGKSSHGARVTI----DVEKVTFVKHLQKSYETEEGKTVILECQTSHT--V 956
Y C A NSAG+ A +T+ D + F+ +S G++V++ C +
Sbjct: 623 TYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISK-PRSVTASLGQSVLISCAIAGDPFP 681
Query: 957 STKWYHNKKEI-SGMDHREIIQ 977
+ W + K + H E++Q
Sbjct: 682 TVHWLRDGKALCKDTGHFEVLQ 703
Score = 81.4 bits (192), Expect = 3e-14
Identities = 51/176 (28%), Positives = 79/176 (44%), Gaps = 3/176 (1%)
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
QK + G+ + + G P W K +++ + + E S + I ++ H
Sbjct: 1178 QKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCG 1237
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
YT+ N G+ +V L V DKP P G +I S+T+ W DGG + Y
Sbjct: 1238 CYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 1297
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESE 1756
+IE + N W ++A ++ +Q L + EY FRV A N G SE + ESE
Sbjct: 1298 SIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 1351
Score = 74.9 bits (176), Expect = 3e-12
Identities = 51/202 (25%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXX 1539
+P+ LK+ +D L C G P P++TW +G+ ++ A++T E
Sbjct: 444 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQD 503
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQ----------------KPVITISNEDIKQ- 1582
Y C+A N G+V S V + + KP I + +
Sbjct: 504 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 563
Query: 1583 KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSK 1642
K G + +T + G PPPEVIW NGN+++ ++++ + + I+E+ +
Sbjct: 564 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGT 623
Query: 1643 YTIEASNTAGTSSVEVTLKVYD 1664
YT EA N+AG + L V +
Sbjct: 624 YTCEAWNSAGEVRTQAVLTVQE 645
Score = 66.5 bits (155), Expect = 1e-09
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE Q AP F +KL+ H +G + +CQV P I W +K ++ F + +
Sbjct: 1022 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQE 1080
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDH 607
++ ++ I + PED G + CVAKN AG A + ++ V +AP S++
Sbjct: 1081 GSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASEN 1126
Score = 65.7 bits (153), Expect = 2e-09
Identities = 47/213 (22%), Positives = 91/213 (42%), Gaps = 8/213 (3%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S +EY + +K +P + L ++ + +T G P P+V W +G +++
Sbjct: 536 SSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQ 595
Query: 1524 TAK-ATYENRXXXXX---XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT---IS 1576
++ +E R Y C A+N GEV T V+ +Q+ T
Sbjct: 596 ESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFI 655
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKEL 1635
++ +G L++ I G P P V W ++G L D + + E + +K++
Sbjct: 656 SKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKV 715
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ H+ +Y I N G S +V+L + + ++
Sbjct: 716 QPWHAGQYEILLKNRVGECSCQVSLMLQNSSAR 748
Score = 64.9 bits (151), Expect = 3e-09
Identities = 70/281 (24%), Positives = 122/281 (43%), Gaps = 37/281 (13%)
Query: 1010 LVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-VVWERDGEIIKPKKNKYDFEKR 1068
L V E P F L+D V E +L+ + + W +G+ I+ ++ +
Sbjct: 438 LAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCE---- 493
Query: 1069 GHIRKLYIRNTSVHDEGEYSCI----LRDESCTAEVTVVE----------LP-------- 1106
+ +L+I++ D G Y+C+ L SC+A VTV E LP
Sbjct: 494 AGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTA 553
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P + L + KV G++ T ++++ V W +G+EIQ S G + L I
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCI 613
Query: 1166 YDCDLDDAGEYSCEVGNS----KCTAILTVEEP---SINFTLRLPEFILVPANTDAYLTV 1218
+ +D G Y+CE NS + A+LTV+EP + + + P + ++
Sbjct: 614 QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISC 673
Query: 1219 EIP-DETLDVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRK 1257
I D V W + K++ +DT F ++ + TL+++K
Sbjct: 674 AIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKK 714
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 33/222 (14%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHS 788
E P I P +++ +++G + +V G P P +TW +N +P+ + L T S
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 789 ITILKPKKVKDEGVYTLKAENS------------EG----------IAET-----SAVIT 821
+ I + +D G YT +A N EG +++T SA
Sbjct: 91 LVIHAVHE-EDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAV 149
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
P+ PP F + + VKE + ++T P P +TW + N + PS ++
Sbjct: 150 ETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSV 209
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ L I V+ + D G Y C+ N +GK+S A ++I
Sbjct: 210 SEKNGMQVLEIHGVNQD-DVGVYTCLVVNGSGKASMSAELSI 250
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/200 (24%), Positives = 87/200 (43%), Gaps = 12/200 (6%)
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
+KV + + + + E+C + ++ +N +G +A V T +D P
Sbjct: 1215 MKVENSENGSKLTILAARQEHCG-CYTLLVENKLGSRQAQ-----VNLTVVDKPDPPAGT 1268
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSIN 1832
I + S+ ++W+ S +GGS + Y +EI K WK +Q L +
Sbjct: 1269 PCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD 1328
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEPES 1891
Y+FR+ A N GTS P + T+G+ P +P++ V VS+ + + +
Sbjct: 1329 HEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPKDEVEVSDDDEKEPEVDYRTVTI 1385
Query: 1892 NGGSPITN-YIIEFKTVKGK 1910
N +++ Y IE + GK
Sbjct: 1386 NTEQKVSDFYDIEERLGSGK 1405
Score = 58.0 bits (134), Expect = 3e-07
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 1262 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 1319
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
FN++DL +H Y R+ A N G SEP + E V GE EEP ++ EV
Sbjct: 1320 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTV--GE---KPEEPKDEVEV 1368
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 5/132 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + L+ + V +G+ ++L QV +P TI W N K +K + +G S++I
Sbjct: 1029 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1088
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTI 850
K +D G+Y A+N G AE S +TV++ P EN + P +R + ++
Sbjct: 1089 EKALP-EDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGT 1147
Query: 851 KLVARVTRNPVP 862
+ A V + P P
Sbjct: 1148 ESDATVKKKPAP 1159
Score = 55.2 bits (127), Expect = 2e-06
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 43/246 (17%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI--------- 680
+G P F +K + +V EG +LL+C++ + P I W G+ + + I
Sbjct: 1025 QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLC 1084
Query: 681 SVAIES----DMHMY------------CSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
SV+IE D +Y CS + E T +R ++SLP V
Sbjct: 1085 SVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPV 1144
Query: 725 L--------KIKTGEKEPP------QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK 770
L K K K PP Q+I+ + VR GESV L +V G T TW K
Sbjct: 1145 LGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMK 1204
Query: 771 NNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
K ++ + ++ + +TIL ++ + G YTL EN G + +TV + +
Sbjct: 1205 FRKQIQESEHMKVENSENGSKLTILAARQ-EHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1263
Query: 828 ENAEPP 833
A P
Sbjct: 1264 PPAGTP 1269
Score = 54.4 bits (125), Expect = 4e-06
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
PP+ L ++V++G+ S ++ G P+P +TW K N P++ S + + + +L+
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 219
Query: 794 PKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
V D GVYT N G A SA ++++
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQ 251
Score = 54.0 bits (124), Expect = 6e-06
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E+ +E P F + Q++ V E + L +V+ +P +I W N + + ++ I +
Sbjct: 1019 EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILS 1078
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
+G + I E D G YKCVA N AG++ +VT+D
Sbjct: 1079 QEGSLCSVSIEKALPE-DRGLYKCVAKNDAGQAECSCQVTVD 1119
Score = 52.8 bits (121), Expect = 1e-05
Identities = 65/309 (21%), Positives = 127/309 (41%), Gaps = 35/309 (11%)
Query: 1100 VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID 1157
+ V+E+ P + L++ V +G + + +G + R W +G IQ++ T +
Sbjct: 438 LAVMEVAPSFSSVLKDCAVIEGQDFVLQCSV-RGTPVPRITWLLNGQPIQYARS---TCE 493
Query: 1158 GKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEE-----------------PSI 1196
+L I D +D G Y+C +G C+A +TV E P+
Sbjct: 494 AGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTA 553
Query: 1197 NFTLRLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLII 1255
L+ + V + +TV++ + +V W + I+++E F + +L I
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCI 613
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLK-VEVVEFP-----PKIVDYEREYRIKRGSDVTLLV 1309
++ +D YTC ++ + + V V+ P P + R G V +
Sbjct: 614 QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISC 673
Query: 1310 DYQAFPQPNDEWIVNSKII-KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P W+ + K + K H + + +L +KKV+ AG Y++ L+N G
Sbjct: 674 AIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGE 733
Query: 1369 ADVEMNVTI 1377
++++ +
Sbjct: 734 CSCQVSLML 742
Score = 52.8 bits (121), Expect = 1e-05
Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P F +KLQD V E +L+ +++S+ A ++W +G+ +K K + G +
Sbjct: 1027 TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQEGSLCS 1085
Query: 1074 LYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
+ I D G Y C+ ++++ C+ +VTV + P T+ K + + +
Sbjct: 1086 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVL 1145
Query: 1130 LTKGDALVR 1138
T+ DA V+
Sbjct: 1146 GTESDATVK 1154
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 1738 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 1795
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 1796 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 1835
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+NLK+ S + N+V+ T + E++ +P ++ L+++ + +
Sbjct: 988 ENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLL 1047
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX----XXXYKCIAFNDH 1556
L C P + W +GK LKT K ++ YKC+A ND
Sbjct: 1048 LQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDA 1107
Query: 1557 GEVETSCVVGIQQKP 1571
G+ E SC V + P
Sbjct: 1108 GQAECSCQVTVDDAP 1122
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 42/94 (44%)
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
E P FI + + +KE T K RV P P +TW+RN + I+ +
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
++ + E D G Y C A+N +G +T++
Sbjct: 91 LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVE 124
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 1712 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 1771
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 1772 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 1830
Query: 924 D 924
+
Sbjct: 1831 E 1831
Score = 45.6 bits (103), Expect = 0.002
Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
E PP+ T+L V +G F ++T + V W K +Q S + ++ Q
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQV 217
Query: 1163 LKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
L+I+ + DD G Y+C V N A ++ E
Sbjct: 218 LEIHGVNQDDVGVYTCLVVNGSGKASMSAE 247
Score = 45.2 bits (102), Expect = 0.003
Identities = 46/199 (23%), Positives = 82/199 (41%), Gaps = 18/199 (9%)
Query: 1013 KETIPEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDGEIIKPKKNKYDFEKRGHI 1071
K T P F++ L D +V + + V+++ +V+W +G I+ ++ + FE+RG
Sbjct: 550 KPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED-FHFEQRGTQ 608
Query: 1072 RKLYIRNTSVHDEGEYSCIL---RDESCTAEVTVVELP-----PEIITRLQNQKVNKGNK 1123
L I+ D G Y+C E T V V+ P P I++ ++ + G
Sbjct: 609 HSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQS 668
Query: 1124 ATFEIELTKGDAL--VRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
+ GD V W +DG + + + H ++ + L + AG+Y
Sbjct: 669 VLISCAIA-GDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILL 727
Query: 1179 --EVGNSKCTAILTVEEPS 1195
VG C L ++ S
Sbjct: 728 KNRVGECSCQVSLMLQNSS 746
Score = 44.8 bits (101), Expect = 0.003
Identities = 58/267 (21%), Positives = 102/267 (38%), Gaps = 24/267 (8%)
Query: 1276 TTKLKVE---VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
T K + E V+E P ++ + G D L + P P W++N + I +
Sbjct: 430 TVKFRCEGLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI---Q 486
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ + + ++ A L I+ D G Y EN G VT+ +K S +L +
Sbjct: 487 YARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPV 546
Query: 1393 DSSS----INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
S I + + + + V+ E I + N + Q S ++
Sbjct: 547 APSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQES-EDFHFEQR 605
Query: 1449 YRFRAYAVNEVDISD-ASETTEYYKVIKETKIQSP-TVEKP-----------LKNITTEP 1495
+ + EV D + T E + E + Q+ TV++P +++T
Sbjct: 606 GTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASL 665
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ + ++C G P P V W RDGK L
Sbjct: 666 GQSVLISCAIAGDPFPTVHWLRDGKAL 692
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 4/101 (3%)
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKD 1934
S+ S S+TL W +GGS + +Y IE K+W ++ T + ++++
Sbjct: 1272 SDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFN--VQDLLPDH 1329
Query: 1935 EIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
E FR+ A N G S P SQ L P P +E+
Sbjct: 1330 EYKFRVRAINVYGTSEP--SQESELTTVGEKPEEPKDEVEV 1368
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/88 (26%), Positives = 40/88 (45%)
Query: 1295 REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
++ + G + L + P W +N K +K K S + S++I+K D
Sbjct: 1036 QDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPED 1095
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPS 1382
G+YK +N+ G A+ VT+ D P+
Sbjct: 1096 RGLYKCVAKNDAGQAECSCQVTVDDAPA 1123
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 1740 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1799
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 1800 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1831
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 4/100 (4%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P+V W++NG + + + + + T + I + KYT EA+N +G
Sbjct: 56 VRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGAR 115
Query: 1655 SVEVTLKVYDKPSKPEG-PVIMREI-SRESVT-IEWKPPL 1691
V V L V +K G PV+ + + R S + +E +P +
Sbjct: 116 QVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAVETRPSI 155
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 1763 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 1822
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 1823 TCTAELIV 1830
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 1740 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1799
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 1800 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 1839
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/103 (22%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +LQ+ V +G K + +++ A + W +G ++ + I L+ +G + I
Sbjct: 1029 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1088
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
+D G Y C + G ++C+ +TV++ + + PE
Sbjct: 1089 EKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 1131
Score = 34.7 bits (76), Expect = 3.7
Identities = 19/78 (24%), Positives = 32/78 (41%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G + I G P P+V W K L+ +++ K V+ I + + YT
Sbjct: 173 KEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYT 232
Query: 1645 IEASNTAGTSSVEVTLKV 1662
N +G +S+ L +
Sbjct: 233 CLVVNGSGKASMSAELSI 250
Score = 34.7 bits (76), Expect = 3.7
Identities = 18/89 (20%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G ++++ + G P P + W NG ++ + T + + + I++ YT
Sbjct: 459 GQDFVLQCSVRGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCL 515
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIM 1675
A N G S + V++K S + ++
Sbjct: 516 AENALGQVSCSAWVTVHEKKSSRKSEYLL 544
Score = 33.9 bits (74), Expect = 6.4
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + PP +IW NG L+ K ++ + + I++ Y
Sbjct: 1043 GKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCV 1102
Query: 1647 ASNTAGTSSVEVTLKVYDKPS 1667
A N AG + + V D P+
Sbjct: 1103 AKNDAGQAECSCQVTVDDAPA 1123
Score = 33.5 bits (73), Expect = 8.5
Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 12/128 (9%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALV-RWFKDGSEIQFSNHIQLTIDGKKQKL 1163
+PP+II ++QKV G ++T + W K +IQ S H+++ KL
Sbjct: 1167 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKL 1226
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAYLTVEIPD 1222
I + G Y+ V N L + +N T + P+ PA T +I
Sbjct: 1227 TILAARQEHCGCYTLLVENK-----LGSRQAQVNLTVVDKPD---PPAGTPC--ASDIRS 1276
Query: 1223 ETLDVTWY 1230
+L ++WY
Sbjct: 1277 SSLTLSWY 1284
>AK056336-1|BAB71154.1| 512|Homo sapiens protein ( Homo sapiens cDNA
FLJ31774 fis, clone NT2RI2008050, weakly similar to
BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN
CORE ).
Length = 512
Score = 105 bits (251), Expect = 2e-21
Identities = 117/461 (25%), Positives = 187/461 (40%), Gaps = 43/461 (9%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGE-EIVPDENISVAIESDMHMYCSVLKITNVKKFQEG 706
G ++EC+ IP P + W FKG+ E+ P + + +LKI + G
Sbjct: 57 GDITVMECKTSGIPPPQVKW-FKGDLELRPSTFLII------DPLLGLLKIQETQDLDAG 109
Query: 707 TYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
YT VA+N G A+ I L + + PP I+ + + G +V L V G P PTI
Sbjct: 110 DYTCVAINEAGRATGKITLDVGS----PPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTI 165
Query: 767 TWCK-NNKPVKALP----TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
W + +N P+ + P + S T ++ IL D+G Y +AEN G ++ +T
Sbjct: 166 KWRRLDNMPIFSRPFSVSSISQLRTGALFILN-LWASDKGTYICEAENQFGKIQSETTVT 224
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
V P + I+ ++ + + NP+P W +N+ ++ + IT
Sbjct: 225 V----TGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITV 280
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETE 941
DG L I V + D G+Y CVASN AG ++ V + V + ++H Q+ T
Sbjct: 281 RSDG---SLHIERVQLQ-DGGEYTCVASNVAGTNNKTTSVVVHV--LPTIQHGQQILSTI 334
Query: 942 EGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
EG V L C+ S +KK G + G C
Sbjct: 335 EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTA 394
Query: 1002 KDQETSTMLVVKETI---PEFI---RKL-QDFEVKEKDVAILEVEINSETAD-----VVW 1049
+ V+ T+ P R L QD V+ +A EV + E + W
Sbjct: 395 TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW 454
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI 1090
++ ++I P ++ F G ++ I T D G Y C+
Sbjct: 455 AKETQLISPFSPRHTFLPSGSMK---ITETRTSDSGMYLCV 492
Score = 102 bits (245), Expect = 1e-20
Identities = 105/423 (24%), Positives = 173/423 (40%), Gaps = 51/423 (12%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVATL 568
P+F+++ GS V C V+GYP P I W R + S+ F + L
Sbjct: 134 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 193
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I ++ D GT+ C A+N G S T + V ++
Sbjct: 194 FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP---------------------- 231
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISVAIESD 687
L GI P+ + V EG + L C L+A P P+ W+ ++ + I+V +
Sbjct: 232 LIGISPSVAN------VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS 285
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREG--EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+H I V+ G YT VA N G + +V+ + + Q++ +
Sbjct: 286 LH-------IERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTI---- 334
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYT 804
+G V L + GNP+P++ W K + + K S G S+ ++ P ++ G Y
Sbjct: 335 --EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGG-EESGEYV 391
Query: 805 LKAENSEGIAETSAVITV-EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
A N+ G A+ +TV P + L ++ EI+V + L V P P
Sbjct: 392 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI 451
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
ITW + ++ISP ++++ T DSG Y CVA+N AG + ++ +
Sbjct: 452 ITWAKETQLISPFSPRHTFLPSGSMKITETRTS---DSGMYLCVATNIAGNVTQAVKLNV 508
Query: 924 DVE 926
E
Sbjct: 509 HGE 511
Score = 98.7 bits (235), Expect = 2e-19
Identities = 80/305 (26%), Positives = 140/305 (45%), Gaps = 24/305 (7%)
Query: 631 GIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM 690
G PP F ++P ++ GS++ L C + PEP I W + + +P + ++ S +
Sbjct: 131 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW--RRLDNMPIFSRPFSVSSISQL 188
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
L I N+ +GTY A N+ G+ + + TG P I P + ++ +
Sbjct: 189 RTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIGISPSVANVIEGQQ 247
Query: 751 SVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILKPKKVKDEGVYTLKA 807
+ + GNP P W KN+ + P +SDG H ++ +++D G YT A
Sbjct: 248 LTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLH----IERVQLQDGGEYTCVA 303
Query: 808 ENSEGI-AETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITW 866
N G +T++V+ PT ++ + Q ++ E + L + + NP PS+ W
Sbjct: 304 SNVAGTNNKTTSVVVHVLPTIQHGQ--------QILSTIEGIPVTLPCKASGNPKPSVIW 355
Query: 867 YRNNEIISPSET-ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
+ E+IS S + DG L + + E +SG+Y C A+N+AG + ++T+ V
Sbjct: 356 SKKGELISTSSAKFSAGADG---SLYVVSPGGE-ESGEYVCTATNTAGYAKRKVQLTVYV 411
Query: 926 EKVTF 930
F
Sbjct: 412 RPRVF 416
Score = 81.4 bits (192), Expect = 3e-14
Identities = 111/517 (21%), Positives = 194/517 (37%), Gaps = 48/517 (9%)
Query: 1172 DAGEYSCEVGNSKCT-----AILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD 1226
DAG Y C NS T + +E P + L T IP
Sbjct: 16 DAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPP--Q 73
Query: 1227 VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVV 1284
V W+K +E LI D L I++ + D +YTCV ++ ++T K+ ++V
Sbjct: 74 VKWFKGD--LELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVG 131
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEW--IVNSKIIKKCKHTKPSIDSKS 1342
PP + + ++ GS+VTL Q +P+P +W + N I + ++
Sbjct: 132 S-PPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRT 190
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWD 1402
+L I + +D G Y EN G E VT+ +P ++ I S N+
Sbjct: 191 GALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAP-----LIGISPSVANVIEG 245
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
+ T+ ++ I WI + Q ++++ S + V +
Sbjct: 246 Q-----QLTLPCTLLAGNPIPERRWIK-NSAMLLQNPYITVRSDGSLH-----IERVQLQ 294
Query: 1463 DASETTEYYKVIKETKIQS--------PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVT 1514
D E T + T ++ PT++ + ++T + L C G P+P V
Sbjct: 295 DGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI 354
Query: 1515 WYRDGKKLKTAKATYENRXXXXXXXXX--XXXXXXYKCIAFNDHGEVETSCVVGIQQKPV 1572
W + G+ + T+ A + Y C A N G + + + +P
Sbjct: 355 WSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPR 414
Query: 1573 ITISNEDIKQKHKV------GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEK 1626
+ + Q V G+E + ++ +PPP + W K + + T
Sbjct: 415 VFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRH--TFLP 472
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
+ ++I E + S S Y A+N AG + V L V+
Sbjct: 473 SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVH 509
Score = 69.7 bits (163), Expect = 1e-10
Identities = 112/509 (22%), Positives = 198/509 (38%), Gaps = 49/509 (9%)
Query: 900 DSGDYKCVASNSAGKSSHGARVT-IDVEKVTFVKHLQKSYETEEGKTVILECQTSHTV-- 956
D+G Y C+ASNSAG + + I+ K+ V Q G ++EC+TS
Sbjct: 16 DAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVV---QSELLVALGDITVMECKTSGIPPP 72
Query: 957 STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE---TSTMLVVK 1013
KW+ E+ +I + D G C+ ++ T + +
Sbjct: 73 QVKWFKGDLELRPSTF--LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV 130
Query: 1014 ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WER-DGEIIKPKKNKYDFEKRGHI 1071
+ P FI++ D ++ L + + W R D I + +
Sbjct: 131 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRT 190
Query: 1072 RKLYIRNTSVHDEGEYSCILRDE----SCTAEVTVVELPPEIITRLQN-QKVNKGNKATF 1126
L+I N D+G Y C ++ VTV L +I + V +G + T
Sbjct: 191 GALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTL 250
Query: 1127 EIELTKGDALV--RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN-- 1182
L G+ + RW K+ + + + +I + DG L I L D GEY+C N
Sbjct: 251 PCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGS---LHIERVQLQDGGEYTCVASNVA 307
Query: 1183 ---SKCTAILTVEEPSINFTLRLPEFIL-VPANTDAYLTVEIPDETLDVTWYKKKSVIED 1238
+K T+++ P+I ++ I +P + P + V W KK +I
Sbjct: 308 GTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGN-PKPS--VIWSKKGELIST 364
Query: 1239 TE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYER- 1295
+ KF+ +D +L + ++ EY C + K KV++ + P++ +R
Sbjct: 365 SSAKFSAGAD---GSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRG 421
Query: 1296 -------EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIK 1348
E + G +VTL + ++ P P W +++I + S S+ I
Sbjct: 422 LSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFL--PSGSMKIT 479
Query: 1349 KVENTDAGIYKLRLENNCGHAD--VEMNV 1375
+ +D+G+Y N G+ V++NV
Sbjct: 480 ETRTSDSGMYLCVATNIAGNVTQAVKLNV 508
Score = 66.9 bits (156), Expect = 7e-10
Identities = 82/401 (20%), Positives = 138/401 (34%), Gaps = 21/401 (5%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVIL 754
L I N G Y +A N G L+ E P+++ ++V G+ ++
Sbjct: 7 LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYI----EAPKLMVVQSELLVALGDITVM 62
Query: 755 SAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIA 814
+ G P P + W K + ++ + ++ + D G YT A N G A
Sbjct: 63 ECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRA 122
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NNEI 872
+ V PP+FI +++++ + L V P P+I W R N I
Sbjct: 123 TGKITLDV-------GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI 175
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
S +++ L I N+ + D G Y C A N GK VT+ +
Sbjct: 176 FSRPFSVSSISQLRTGALFILNLWAS-DKGTYICEAENQFGKIQSETTVTVTGLVAPLIG 234
Query: 933 HLQKSYETEEGKTVILECQT---SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
EG+ + L C + +W N + + + +G
Sbjct: 235 ISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQ 294
Query: 990 XXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETADVV 1048
+ + V T VV +P Q E L + + + V+
Sbjct: 295 DGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI 354
Query: 1049 WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
W + GE+I K+ G LY+ + + GEY C
Sbjct: 355 WSKKGELISTSSAKFSAGADG---SLYVVSPGGEESGEYVC 392
Score = 63.3 bits (147), Expect = 9e-09
Identities = 96/429 (22%), Positives = 163/429 (37%), Gaps = 35/429 (8%)
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTTKLK--VEVVEFPPKIVDYEREYRIKRGSDVTLLV 1309
TL I+ D Y C+ ++ T K + +E PK++ + E + G +
Sbjct: 6 TLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE-APKLMVVQSELLVALGDITVMEC 64
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P +W ++ T ID L I++ ++ DAG Y N G A
Sbjct: 65 KTSGIPPPQVKWFKGDLELRPS--TFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRA 122
Query: 1370 DVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWIS 1429
++ LD SPP + + + +++ E N T+ YV Y E T +W
Sbjct: 123 TGKIT---LDVGSPP----VFIQEPADVSM-----EIGSNVTLPCYVQGYPE-PTIKWRR 169
Query: 1430 VKNITK-----TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
+ N+ + +SI L+T + + +A ++ +E ++ K+ ET + +
Sbjct: 170 LDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAEN-QFGKIQSETTVTVTGL 228
Query: 1485 EKPLKNITTEPNEDIE-----LTC-IFGGVPQPKVTWYRDGKKL-KTAKATYENRXXXXX 1537
PL I+ IE L C + G P P+ W ++ L + T +
Sbjct: 229 VAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHI 288
Query: 1538 XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE 1597
Y C+A N G + V + P I + + G +
Sbjct: 289 ERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIE--GIPVTLPCKAS 346
Query: 1598 GIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVE 1657
G P P VIW K G +L + + S+ + S +Y A+NTAG + +
Sbjct: 347 GNPKPSVIWSKKG-ELISTSSAKFSAGADGSLYVVSP-GGEESGEYVCTATNTAGYAKRK 404
Query: 1658 VTLKVYDKP 1666
V L VY +P
Sbjct: 405 VQLTVYVRP 413
Score = 54.0 bits (124), Expect = 6e-06
Identities = 106/508 (20%), Positives = 195/508 (38%), Gaps = 36/508 (7%)
Query: 1074 LYIRNTSVHDEGEYSCILRDESCT----AEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
L+I+N + D G Y C+ + + T + + +E P ++ + V G+ E +
Sbjct: 7 LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQ-SELLVALGDITVMECK 65
Query: 1130 LTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN--SKC 1185
T G V+WFK E++ S L ID LKI + DAG+Y+C N +
Sbjct: 66 -TSGIPPPQVKWFKGDLELRPSTF--LIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRA 122
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEI---PDETLDVTWYKKKSVIEDTEKF 1242
T +T++ S ++ P + + ++ L + P+ T+ +
Sbjct: 123 TGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSV 182
Query: 1243 TLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKIVDYEREY-RI 1299
+ IS ++ L I D+ Y C + K ++ V V ++ +
Sbjct: 183 SSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANV 242
Query: 1300 KRGSDVTLLVDYQA-FPQPNDEWIVNSKIIKKCKHTKPSIDSKS-ASLTIKKVENTDAGI 1357
G +TL A P P WI NS ++ + P I +S SL I++V+ D G
Sbjct: 243 IEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQ----NPYITVRSDGSLHIERVQLQDGGE 298
Query: 1358 YKLRLENNCGHADVEMNVTILDKPS-PPGKPNILEIDSSSINICWDEPENTGNSTIIYYV 1416
Y N G + +V + P+ G+ + I+ + + N S I +
Sbjct: 299 YTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI--WS 356
Query: 1417 VEYQEIDTTEWISVKNITKTQTSIQNLKT--NSSYRFRAYAVNEVDISDAS-ETTEYYKV 1473
+ + I T+ S K S+ + S + A N + + T Y +
Sbjct: 357 KKGELISTS---SAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRP 413
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK--TAKATYEN 1531
+ + +KP++ I+ E++ L C +P P +TW ++ + + + + T+
Sbjct: 414 RVFGDQRGLSQDKPVE-ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLP 472
Query: 1532 RXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
Y C+A N G V
Sbjct: 473 SGSMKITETRTSDSGMYLCVATNIAGNV 500
Score = 51.2 bits (117), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G EC+ G P PQ+ WF+ ++PS D + L I+E DAG +TC
Sbjct: 57 GDITVMECKTSGIPPPQVKWFKGDLELRPS---TFLIIDPLLGLLKIQETQDLDAGDYTC 113
Query: 584 VAKNAAGFASSTTELIVEAP 603
VA N AG A+ L V +P
Sbjct: 114 VAINEAGRATGKITLDVGSP 133
Score = 49.6 bits (113), Expect = 1e-04
Identities = 48/213 (22%), Positives = 86/213 (40%), Gaps = 13/213 (6%)
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR------DGKKLKTAKATYENRXXXXX 1537
+++P +++ E ++ L C G P+P + W R + + +
Sbjct: 137 IQEPA-DVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFI 195
Query: 1538 XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQ--KPVITISNEDIKQKHKVGDEWLVTAV 1595
Y C A N G++++ V + P+I IS + + L +
Sbjct: 196 LNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGIS-PSVANVIEGQQLTLPCTL 254
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ G P PE W KN L + IT + S + I+ ++ +YT ASN AGT++
Sbjct: 255 LAGNPIPERRWIKNSAMLLQNPY--ITVRSDGS-LHIERVQLQDGGEYTCVASNVAGTNN 311
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWK 1688
++ V+ P+ G I+ I VT+ K
Sbjct: 312 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCK 344
Score = 46.4 bits (105), Expect = 0.001
Identities = 49/228 (21%), Positives = 81/228 (35%), Gaps = 31/228 (13%)
Query: 500 KPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMY 559
K TS + P + T +G V C+ G P+P + W ++ +I S
Sbjct: 312 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS---SAK 368
Query: 560 YDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXX 619
+ +L + E++G + C A N AG+A +L V G + +
Sbjct: 369 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLS----- 423
Query: 620 XXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDEN 679
KP V G ++ L C + ++P P I W + + I P
Sbjct: 424 -----------------QDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSP 466
Query: 680 ISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
+ S +KIT + G Y VA N G + + L +
Sbjct: 467 RHTFLPS------GSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNV 508
Score = 33.9 bits (74), Expect = 6.4
Identities = 16/38 (42%), Positives = 23/38 (60%), Gaps = 1/38 (2%)
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
TL I+ P+DAG + C+A N+AG + L +EAP
Sbjct: 6 TLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAP 43
>AF069603-1|AAD15923.1| 1793|Homo sapiens myosin light chain kinase
isoform 3B protein.
Length = 1793
Score = 105 bits (251), Expect = 2e-21
Identities = 73/246 (29%), Positives = 105/246 (42%), Gaps = 12/246 (4%)
Query: 487 KLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
K + +D V P +E AP F+ R +G+T +FE +V GYP PQ+TW R
Sbjct: 14 KTSLSVDPSRVDSMPLTE----APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRN 69
Query: 547 TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I F + +LVI V ED G +TC A N +G T EL VE +
Sbjct: 70 GQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAK 129
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGI----PPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ V + I PP F+ K V EG C++ P+
Sbjct: 130 QLGQPVVSKTLGDRFSASAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQ 189
Query: 663 PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLP 722
P + WL + P +SV+ ++ M VL+I V + G YT + VN G+AS+
Sbjct: 190 PQVTWLKGNVPLQPSARVSVSEKNGM----QVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 723 IVLKIK 728
L I+
Sbjct: 246 AELSIQ 251
Score = 101 bits (242), Expect = 3e-20
Identities = 75/303 (24%), Positives = 130/303 (42%), Gaps = 28/303 (9%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+FS K V EG D +L+C + P P I WL G+ I + A +++H
Sbjct: 443 VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELH-- 500
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASL---------------PIVLKIKTGEKEPPQ 736
I + GTYT +A N G+ S +L + + P
Sbjct: 501 -----IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPI 555
Query: 737 VIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILK 793
++ L + V G V ++ QV GNP P + W N ++ + G HS+ I +
Sbjct: 556 FLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWI-Q 614
Query: 794 PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLV 853
+D G YT +A NS G T AV+TV+EP + P FI++ + +T ++ +
Sbjct: 615 EVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP--HDGTQPWFISKPRSVTASLGQSVLIS 672
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+ +P P++ W R+ + + + E++ ++ +G Y+ + N G
Sbjct: 673 CAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVG 732
Query: 914 KSS 916
+ S
Sbjct: 733 ECS 735
Score = 98.3 bits (234), Expect = 3e-19
Identities = 75/267 (28%), Positives = 114/267 (42%), Gaps = 20/267 (7%)
Query: 508 MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
+AP F L+ +G +C V G P P+ITW +P Q + + VA
Sbjct: 443 VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNG---QPIQ-YARSTCEAGVAE 498
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
L I++ PED GT+TC+A+NA G S + + V S SE +
Sbjct: 499 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPS--------- 549
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ P F + V +GS + + ++ P P++ WL G EI E+
Sbjct: 550 --KPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGT 607
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI-KTGEKEPPQVIEPLKSMIV 746
H L I V GTYT A N GE VL + + + P I +S+
Sbjct: 608 QHS----LWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTA 663
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNK 773
G+SV++S + G+P PT+ W ++ K
Sbjct: 664 SLGQSVLISCAIAGDPFPTVHWLRDGK 690
Score = 95.1 bits (226), Expect = 2e-18
Identities = 50/184 (27%), Positives = 83/184 (45%), Gaps = 1/184 (0%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP+I+ + + +++ G V L W+ K I+ +H K + LT
Sbjct: 1168 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQDSEHIKVENSENGSKLT 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDEPE 1405
I G Y L +EN G ++N+T++DKP PP G P +I SSS+ + W
Sbjct: 1228 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1287
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G S + Y +E + W + T ++Q+L + Y+FR A+N S+ S
Sbjct: 1288 YDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPS 1347
Query: 1466 ETTE 1469
+ +E
Sbjct: 1348 QESE 1351
Score = 94.7 bits (225), Expect = 3e-18
Identities = 69/241 (28%), Positives = 109/241 (45%), Gaps = 30/241 (12%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P + + APIF++ L DGS V QV G P P++ W I+ S+DF +
Sbjct: 545 PVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH-FE 603
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
+L I+EVFPED GT+TC A N+AG + L V+ P H
Sbjct: 604 QRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP---H------------- 647
Query: 621 XXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI 680
+G P F KP++ G +L+ C + P P + WL G+ + D
Sbjct: 648 ---------DGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGH 698
Query: 681 SVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK-TGEKEPPQVIE 739
++++ ++ VLK V+ + G Y ++ NR GE S + L ++ + + P+ E
Sbjct: 699 FEVLQNE-DVFTLVLK--KVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGRE 755
Query: 740 P 740
P
Sbjct: 756 P 756
Score = 89.4 bits (212), Expect = 1e-16
Identities = 42/117 (35%), Positives = 69/117 (58%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 1663 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 1722
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T E IVE
Sbjct: 1723 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAEHIVE 1779
Score = 85.0 bits (201), Expect = 3e-15
Identities = 69/262 (26%), Positives = 111/262 (42%), Gaps = 22/262 (8%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P LK V +G+ +L V G P P ITW N +P++ + + + I +
Sbjct: 445 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHI-QD 503
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN----------AEP--PLFINRFQEI 842
+D G YT AEN+ G SA +TV E ++P P+F+ ++
Sbjct: 504 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 563
Query: 843 TVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSG 902
V + + + +V+ NP P + W N I SE G L I V E D+G
Sbjct: 564 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPE-DTG 622
Query: 903 DYKCVASNSAGKSSHGARVTI----DVEKVTFVKHLQKSYETEEGKTVILECQTSHT--V 956
Y C A NSAG+ A +T+ D + F+ +S G++V++ C +
Sbjct: 623 TYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISK-PRSVTASLGQSVLISCAIAGDPFP 681
Query: 957 STKWYHNKKEI-SGMDHREIIQ 977
+ W + K + H E++Q
Sbjct: 682 TVHWLRDGKALCKDTGHFEVLQ 703
Score = 81.8 bits (193), Expect = 2e-14
Identities = 51/176 (28%), Positives = 80/176 (45%), Gaps = 3/176 (1%)
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
QK + G+ + + G P W K ++++ + + E S + I ++ H
Sbjct: 1178 QKVRAGESVELFGKVTGTQPITCTWMKFRKQIQDSEHIKVENSENGSKLTILAARQEHCG 1237
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
YT+ N G+ +V L V DKP P G +I S+T+ W DGG + Y
Sbjct: 1238 CYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 1297
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESE 1756
+IE + N W ++A ++ +Q L + EY FRV A N G SE + ESE
Sbjct: 1298 SIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 1351
Score = 74.9 bits (176), Expect = 3e-12
Identities = 51/202 (25%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXX 1539
+P+ LK+ +D L C G P P++TW +G+ ++ A++T E
Sbjct: 444 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQD 503
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQ----------------KPVITISNEDIKQ- 1582
Y C+A N G+V S V + + KP I + +
Sbjct: 504 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 563
Query: 1583 KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSK 1642
K G + +T + G PPPEVIW NGN+++ ++++ + + I+E+ +
Sbjct: 564 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPEDTGT 623
Query: 1643 YTIEASNTAGTSSVEVTLKVYD 1664
YT EA N+AG + L V +
Sbjct: 624 YTCEAWNSAGEVRTQAVLTVQE 645
Score = 65.7 bits (153), Expect = 2e-09
Identities = 47/213 (22%), Positives = 91/213 (42%), Gaps = 8/213 (3%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S +EY + +K +P + L ++ + +T G P P+V W +G +++
Sbjct: 536 SSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQ 595
Query: 1524 TAK-ATYENRXXXXX---XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT---IS 1576
++ +E R Y C A+N GEV T V+ +Q+ T
Sbjct: 596 ESEDFHFEQRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFI 655
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKEL 1635
++ +G L++ I G P P V W ++G L D + + E + +K++
Sbjct: 656 SKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKV 715
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ H+ +Y I N G S +V+L + + ++
Sbjct: 716 QPWHAGQYEILLKNRVGECSCQVSLMLQNSSAR 748
Score = 64.9 bits (151), Expect = 3e-09
Identities = 70/281 (24%), Positives = 122/281 (43%), Gaps = 37/281 (13%)
Query: 1010 LVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-VVWERDGEIIKPKKNKYDFEKR 1068
L V E P F L+D V E +L+ + + W +G+ I+ ++ +
Sbjct: 438 LAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCE---- 493
Query: 1069 GHIRKLYIRNTSVHDEGEYSCI----LRDESCTAEVTVVE----------LP-------- 1106
+ +L+I++ D G Y+C+ L SC+A VTV E LP
Sbjct: 494 AGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTA 553
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P + L + KV G++ T ++++ V W +G+EIQ S G + L I
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWI 613
Query: 1166 YDCDLDDAGEYSCEVGNS----KCTAILTVEEP---SINFTLRLPEFILVPANTDAYLTV 1218
+ +D G Y+CE NS + A+LTV+EP + + + P + ++
Sbjct: 614 QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISC 673
Query: 1219 EIP-DETLDVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRK 1257
I D V W + K++ +DT F ++ + TL+++K
Sbjct: 674 AIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKK 714
Score = 62.9 bits (146), Expect = 1e-08
Identities = 60/250 (24%), Positives = 102/250 (40%), Gaps = 23/250 (9%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE Q AP F +KL+ H +G + +CQV P I W +K ++ F + +
Sbjct: 1022 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQE 1080
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDH--GSEM-------- 611
++ ++ I + ED G + CVAKN AG A + ++ V +AP S++ EM
Sbjct: 1081 GSLCSVSIEKALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSS 1140
Query: 612 ------TVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDI 665
T +PP + P+ Q V G + L ++
Sbjct: 1141 LPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITC 1200
Query: 666 AWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVL 725
W+ ++I E+I V + S L I ++ G YT++ N+ G + L
Sbjct: 1201 TWMKFRKQIQDSEHIKVENSEN----GSKLTILAARQEHCGCYTLLVENKLGSRQAQVNL 1256
Query: 726 KIKTGEKEPP 735
+ + +PP
Sbjct: 1257 TV-VDKPDPP 1265
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 33/222 (14%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHS 788
E P I P +++ +++G + +V G P P +TW +N +P+ + L T S
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 789 ITILKPKKVKDEGVYTLKAENS------------EG----------IAET-----SAVIT 821
+ I + +D G YT +A N EG +++T SA
Sbjct: 91 LVIHAVHE-EDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAV 149
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
P+ PP F + + VKE + ++T P P +TW + N + PS ++
Sbjct: 150 ETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSV 209
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ L I V+ + D G Y C+ N +GK+S A ++I
Sbjct: 210 SEKNGMQVLEIHGVNQD-DVGVYTCLVVNGSGKASMSAELSI 250
Score = 56.8 bits (131), Expect = 8e-07
Identities = 38/132 (28%), Positives = 65/132 (49%), Gaps = 5/132 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + L+ + V +G+ ++L QV +P TI W N K +K + +G S++I
Sbjct: 1029 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1088
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTI 850
K ++D G+Y A+N G AE S +TV++ P EN + P +R + ++
Sbjct: 1089 EK-ALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGT 1147
Query: 851 KLVARVTRNPVP 862
+ A V + P P
Sbjct: 1148 ESDATVKKKPAP 1159
Score = 56.8 bits (131), Expect = 8e-07
Identities = 40/158 (25%), Positives = 69/158 (43%), Gaps = 10/158 (6%)
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
IKV + + + + E+C + ++ +N +G +A V T +D P
Sbjct: 1215 IKVENSENGSKLTILAARQEHCG-CYTLLVENKLGSRQAQ-----VNLTVVDKPDPPAGT 1268
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSIN 1832
I + S+ ++W+ S +GGS + Y +EI K WK +Q L +
Sbjct: 1269 PCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD 1328
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR 1870
Y+FR+ A N GTS P + T+G+ P +P+
Sbjct: 1329 HEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPK 1363
Score = 55.2 bits (127), Expect = 2e-06
Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 2/92 (2%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 1262 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 1319
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
FN++DL +H Y R+ A N G SEP + E
Sbjct: 1320 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 1351
Score = 54.8 bits (126), Expect = 3e-06
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 43/246 (17%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI--------- 680
+G P F +K + +V EG +LL+C++ + P I W G+ + + I
Sbjct: 1025 QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLC 1084
Query: 681 SVAIES----DMHMY------------CSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
SV+IE D +Y CS + E T +R ++SLP V
Sbjct: 1085 SVSIEKALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPV 1144
Query: 725 L--------KIKTGEKEPP------QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK 770
L K K K PP Q+I+ + VR GESV L +V G T TW K
Sbjct: 1145 LGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMK 1204
Query: 771 NNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
K + + + ++ + +TIL ++ + G YTL EN G + +TV + +
Sbjct: 1205 FRKQIQDSEHIKVENSENGSKLTILAARQ-EHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1263
Query: 828 ENAEPP 833
A P
Sbjct: 1264 PPAGTP 1269
Score = 54.4 bits (125), Expect = 4e-06
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
PP+ L ++V++G+ S ++ G P+P +TW K N P++ S + + + +L+
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 219
Query: 794 PKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
V D GVYT N G A SA ++++
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQ 251
Score = 54.0 bits (124), Expect = 6e-06
Identities = 39/152 (25%), Positives = 69/152 (45%), Gaps = 7/152 (4%)
Query: 452 NQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNE-KIDKLPVFEKPTSEEQSMAP 510
++D+ + Q+ T+ W+ + D YT E + + ++P Q P
Sbjct: 597 SEDFHFEQRG-TQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ---P 652
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLV 569
F+ K R G +V C + G P P + W R A+ K + F++ ++D V TLV
Sbjct: 653 WFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNED-VFTLV 711
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+++V P AG + + KN G S L+++
Sbjct: 712 LKKVQPWHAGQYEILLKNRVGECSCQVSLMLQ 743
Score = 54.0 bits (124), Expect = 6e-06
Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 6/129 (4%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P F +KLQD V E +L+ +++S+ A ++W +G+ +K K + G +
Sbjct: 1027 TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQEGSLCS 1085
Query: 1074 LYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
+ I + D G Y C+ ++++ C+ +VTV + P T+ K + + +
Sbjct: 1086 VSIEKALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVL 1145
Query: 1130 LTKGDALVR 1138
T+ DA V+
Sbjct: 1146 GTESDATVK 1154
Score = 53.6 bits (123), Expect = 7e-06
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E+ +E P F + Q++ V E + L +V+ +P +I W N + + ++ I +
Sbjct: 1019 EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILS 1078
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
+G + I E D G YKCVA N AG++ +VT+D
Sbjct: 1079 QEGSLCSVSIEKALLE-DRGLYKCVAKNDAGQAECSCQVTVD 1119
Score = 52.0 bits (119), Expect = 2e-05
Identities = 65/309 (21%), Positives = 127/309 (41%), Gaps = 35/309 (11%)
Query: 1100 VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID 1157
+ V+E+ P + L++ V +G + + +G + R W +G IQ++ T +
Sbjct: 438 LAVMEVAPSFSSVLKDCAVIEGQDFVLQCSV-RGTPVPRITWLLNGQPIQYARS---TCE 493
Query: 1158 GKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEE-----------------PSI 1196
+L I D +D G Y+C +G C+A +TV E P+
Sbjct: 494 AGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTA 553
Query: 1197 NFTLRLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLII 1255
L+ + V + +TV++ + +V W + I+++E F + +L I
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWI 613
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLK-VEVVEFP-----PKIVDYEREYRIKRGSDVTLLV 1309
++ +D YTC ++ + + V V+ P P + R G V +
Sbjct: 614 QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISC 673
Query: 1310 DYQAFPQPNDEWIVNSKII-KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P W+ + K + K H + + +L +KKV+ AG Y++ L+N G
Sbjct: 674 AIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGE 733
Query: 1369 ADVEMNVTI 1377
++++ +
Sbjct: 734 CSCQVSLML 742
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+NLK+ S + N+V+ T + E++ +P ++ L+++ + +
Sbjct: 988 ENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLL 1047
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRX----XXXXXXXXXXXXXXYKCIAFNDH 1556
L C P + W +GK LKT K ++ YKC+A ND
Sbjct: 1048 LQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALLEDRGLYKCVAKNDA 1107
Query: 1557 GEVETSCVVGIQQKP 1571
G+ E SC V + P
Sbjct: 1108 GQAECSCQVTVDDAP 1122
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 42/94 (44%)
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
E P FI + + +KE T K RV P P +TW+RN + I+ +
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
++ + E D G Y C A+N +G +T++
Sbjct: 91 LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVE 124
Score = 47.2 bits (107), Expect = 6e-04
Identities = 34/105 (32%), Positives = 55/105 (52%), Gaps = 6/105 (5%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 1686 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 1743
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLP---IVLKIKTGEKE 733
CS++ I++V + YT AVN GEA+ IV ++ GE E
Sbjct: 1744 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAEHIVETMEEGEGE 1787
Score = 46.8 bits (106), Expect = 9e-04
Identities = 46/199 (23%), Positives = 83/199 (41%), Gaps = 18/199 (9%)
Query: 1013 KETIPEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDGEIIKPKKNKYDFEKRGHI 1071
K T P F++ L D +V + + V+++ +V+W +G I+ ++ + FE+RG
Sbjct: 550 KPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED-FHFEQRGTQ 608
Query: 1072 RKLYIRNTSVHDEGEYSCIL---RDESCTAEVTVVELP-----PEIITRLQNQKVNKGNK 1123
L+I+ D G Y+C E T V V+ P P I++ ++ + G
Sbjct: 609 HSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQS 668
Query: 1124 ATFEIELTKGDAL--VRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
+ GD V W +DG + + + H ++ + L + AG+Y
Sbjct: 669 VLISCAIA-GDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILL 727
Query: 1179 --EVGNSKCTAILTVEEPS 1195
VG C L ++ S
Sbjct: 728 KNRVGECSCQVSLMLQNSS 746
Score = 45.6 bits (103), Expect = 0.002
Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
E PP+ T+L V +G F ++T + V W K +Q S + ++ Q
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQV 217
Query: 1163 LKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
L+I+ + DD G Y+C V N A ++ E
Sbjct: 218 LEIHGVNQDDVGVYTCLVVNGSGKASMSAE 247
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/113 (23%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 1660 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 1719
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSS 916
W+++++ I S ++D + N L+I++V + D Y C A NS G+++
Sbjct: 1720 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEAT 1771
Score = 43.6 bits (98), Expect = 0.008
Identities = 58/267 (21%), Positives = 102/267 (38%), Gaps = 24/267 (8%)
Query: 1276 TTKLKVE---VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
T K + E V+E P ++ + G D L + P P W++N + I +
Sbjct: 430 TVKFRCEGLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI---Q 486
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ + + ++ A L I+ D G Y EN G VT+ +K S +L +
Sbjct: 487 YARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPV 546
Query: 1393 DSSS----INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
S I + + + + V+ E I + N + Q S ++
Sbjct: 547 APSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQES-EDFHFEQR 605
Query: 1449 YRFRAYAVNEVDISD-ASETTEYYKVIKETKIQSP-TVEKP-----------LKNITTEP 1495
+ + EV D + T E + E + Q+ TV++P +++T
Sbjct: 606 GTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASL 665
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ + ++C G P P V W RDGK L
Sbjct: 666 GQSVLISCAIAGDPFPTVHWLRDGKAL 692
Score = 43.6 bits (98), Expect = 0.008
Identities = 23/88 (26%), Positives = 40/88 (45%)
Query: 1295 REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
++ + G + L + P W +N K +K K S + S++I+K D
Sbjct: 1036 QDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALLED 1095
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPS 1382
G+YK +N+ G A+ VT+ D P+
Sbjct: 1096 RGLYKCVAKNDAGQAECSCQVTVDDAPA 1123
Score = 43.2 bits (97), Expect = 0.010
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKD 1934
S+ S S+TL W +GGS + +Y IE K+W ++ T + ++++
Sbjct: 1272 SDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFN--VQDLLPDH 1329
Query: 1935 EIIFRISAENTVGVSLPTESQSV 1957
E FR+ A N G S P++ +
Sbjct: 1330 EYKFRVRAINVYGTSEPSQESEL 1352
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 4/100 (4%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P+V W++NG + + + + + T + I + KYT EA+N +G
Sbjct: 56 VRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGAR 115
Query: 1655 SVEVTLKVYDKPSKPEG-PVIMREI-SRESVT-IEWKPPL 1691
V V L V +K G PV+ + + R S + +E +P +
Sbjct: 116 QVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAVETRPSI 155
Score = 40.7 bits (91), Expect = 0.056
Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 1688 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1747
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
I D DD +Y+C+ NS A T E
Sbjct: 1748 ISDVCGDDDAKYTCKAVNSLGEATCTAE 1775
Score = 39.9 bits (89), Expect = 0.098
Identities = 18/61 (29%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 1711 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 1770
Query: 1655 S 1655
+
Sbjct: 1771 T 1771
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/103 (23%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +LQ+ V +G K + +++ A + W +G ++ + I L+ +G + I
Sbjct: 1029 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1088
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
L+D G Y C + G ++C+ +TV++ + + PE
Sbjct: 1089 EKALLEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 1131
Score = 37.1 bits (82), Expect = 0.69
Identities = 25/100 (25%), Positives = 43/100 (43%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 1688 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1747
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A VE E E
Sbjct: 1748 ISDVCGDDDAKYTCKAVNSLGEATCTAEHIVETMEEGEGE 1787
Score = 34.7 bits (76), Expect = 3.7
Identities = 19/78 (24%), Positives = 32/78 (41%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G + I G P P+V W K L+ +++ K V+ I + + YT
Sbjct: 173 KEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYT 232
Query: 1645 IEASNTAGTSSVEVTLKV 1662
N +G +S+ L +
Sbjct: 233 CLVVNGSGKASMSAELSI 250
Score = 34.7 bits (76), Expect = 3.7
Identities = 18/89 (20%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G ++++ + G P P + W NG ++ + T + + + I++ YT
Sbjct: 459 GQDFVLQCSVRGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCL 515
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIM 1675
A N G S + V++K S + ++
Sbjct: 516 AENALGQVSCSAWVTVHEKKSSRKSEYLL 544
Score = 34.7 bits (76), Expect = 3.7
Identities = 34/128 (26%), Positives = 54/128 (42%), Gaps = 12/128 (9%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALV-RWFKDGSEIQFSNHIQLTIDGKKQKL 1163
+PP+II ++QKV G ++T + W K +IQ S HI++ KL
Sbjct: 1167 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQDSEHIKVENSENGSKL 1226
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAYLTVEIPD 1222
I + G Y+ V N L + +N T + P+ PA T +I
Sbjct: 1227 TILAARQEHCGCYTLLVENK-----LGSRQAQVNLTVVDKPD---PPAGTPC--ASDIRS 1276
Query: 1223 ETLDVTWY 1230
+L ++WY
Sbjct: 1277 SSLTLSWY 1284
Score = 33.9 bits (74), Expect = 6.4
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + PP +IW NG L+ K ++ + + I++ Y
Sbjct: 1043 GKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALLEDRGLYKCV 1102
Query: 1647 ASNTAGTSSVEVTLKVYDKPS 1667
A N AG + + V D P+
Sbjct: 1103 AKNDAGQAECSCQVTVDDAPA 1123
>AF069601-1|AAD15921.2| 1845|Homo sapiens myosin light chain kinase
isoform 2 protein.
Length = 1845
Score = 105 bits (251), Expect = 2e-21
Identities = 73/246 (29%), Positives = 105/246 (42%), Gaps = 12/246 (4%)
Query: 487 KLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
K + +D V P +E AP F+ R +G+T +FE +V GYP PQ+TW R
Sbjct: 14 KTSLSVDPSRVDSMPLTE----APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRN 69
Query: 547 TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I F + +LVI V ED G +TC A N +G T EL VE +
Sbjct: 70 GQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAK 129
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGI----PPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ V + I PP F+ K V EG C++ P+
Sbjct: 130 QLGQPVVSKTLGDRFSASAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQ 189
Query: 663 PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLP 722
P + WL + P +SV+ ++ M VL+I V + G YT + VN G+AS+
Sbjct: 190 PQVTWLKGNVPLQPSARVSVSEKNGM----QVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 723 IVLKIK 728
L I+
Sbjct: 246 AELSIQ 251
Score = 101 bits (242), Expect = 3e-20
Identities = 75/303 (24%), Positives = 130/303 (42%), Gaps = 28/303 (9%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P+FS K V EG D +L+C + P P I WL G+ I + A +++H
Sbjct: 443 VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELH-- 500
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASL---------------PIVLKIKTGEKEPPQ 736
I + GTYT +A N G+ S +L + + P
Sbjct: 501 -----IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPI 555
Query: 737 VIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILK 793
++ L + V G V ++ QV GNP P + W N ++ + G HS+ I +
Sbjct: 556 FLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWI-Q 614
Query: 794 PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLV 853
+D G YT +A NS G T AV+TV+EP + P FI++ + +T ++ +
Sbjct: 615 EVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP--HDGTQPWFISKPRSVTASLGQSVLIS 672
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+ +P P++ W R+ + + + E++ ++ +G Y+ + N G
Sbjct: 673 CAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVG 732
Query: 914 KSS 916
+ S
Sbjct: 733 ECS 735
Score = 98.3 bits (234), Expect = 3e-19
Identities = 75/267 (28%), Positives = 114/267 (42%), Gaps = 20/267 (7%)
Query: 508 MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
+AP F L+ +G +C V G P P+ITW +P Q + + VA
Sbjct: 443 VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNG---QPIQ-YARSTCEAGVAE 498
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXAD 627
L I++ PED GT+TC+A+NA G S + + V S SE +
Sbjct: 499 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPS--------- 549
Query: 628 ILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESD 687
+ P F + V +GS + + ++ P P++ WL G EI E+
Sbjct: 550 --KPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGT 607
Query: 688 MHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI-KTGEKEPPQVIEPLKSMIV 746
H L I V GTYT A N GE VL + + + P I +S+
Sbjct: 608 QHS----LWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTA 663
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNK 773
G+SV++S + G+P PT+ W ++ K
Sbjct: 664 SLGQSVLISCAIAGDPFPTVHWLRDGK 690
Score = 96.3 bits (229), Expect = 1e-18
Identities = 53/200 (26%), Positives = 90/200 (45%), Gaps = 1/200 (0%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP+I+ + + +++ G V L W+ K I++ +H K + LT
Sbjct: 1168 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLT 1227
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDEPE 1405
I G Y L +EN G ++N+T++DKP PP G P +I SSS+ + W
Sbjct: 1228 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 1287
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G S + Y +E + W + T ++Q+L + Y+FR A+N S+ S
Sbjct: 1288 YDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPS 1347
Query: 1466 ETTEYYKVIKETKIQSPTVE 1485
+ +E V ++ + VE
Sbjct: 1348 QESELTTVGEKPEEPKDEVE 1367
Score = 94.7 bits (225), Expect = 3e-18
Identities = 69/241 (28%), Positives = 109/241 (45%), Gaps = 30/241 (12%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P + + APIF++ L DGS V QV G P P++ W I+ S+DF +
Sbjct: 545 PVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFH-FE 603
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
+L I+EVFPED GT+TC A N+AG + L V+ P H
Sbjct: 604 QRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEP---H------------- 647
Query: 621 XXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI 680
+G P F KP++ G +L+ C + P P + WL G+ + D
Sbjct: 648 ---------DGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGH 698
Query: 681 SVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK-TGEKEPPQVIE 739
++++ ++ VLK V+ + G Y ++ NR GE S + L ++ + + P+ E
Sbjct: 699 FEVLQNE-DVFTLVLK--KVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGRE 755
Query: 740 P 740
P
Sbjct: 756 P 756
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 1715 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 1774
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 1775 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1831
Score = 85.0 bits (201), Expect = 3e-15
Identities = 69/262 (26%), Positives = 111/262 (42%), Gaps = 22/262 (8%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P LK V +G+ +L V G P P ITW N +P++ + + + I +
Sbjct: 445 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHI-QD 503
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEEN----------AEP--PLFINRFQEI 842
+D G YT AEN+ G SA +TV E ++P P+F+ ++
Sbjct: 504 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 563
Query: 843 TVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSG 902
V + + + +V+ NP P + W N I SE G L I V E D+G
Sbjct: 564 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPE-DTG 622
Query: 903 DYKCVASNSAGKSSHGARVTI----DVEKVTFVKHLQKSYETEEGKTVILECQTSHT--V 956
Y C A NSAG+ A +T+ D + F+ +S G++V++ C +
Sbjct: 623 TYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISK-PRSVTASLGQSVLISCAIAGDPFP 681
Query: 957 STKWYHNKKEI-SGMDHREIIQ 977
+ W + K + H E++Q
Sbjct: 682 TVHWLRDGKALCKDTGHFEVLQ 703
Score = 81.4 bits (192), Expect = 3e-14
Identities = 51/176 (28%), Positives = 79/176 (44%), Gaps = 3/176 (1%)
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
QK + G+ + + G P W K +++ + + E S + I ++ H
Sbjct: 1178 QKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCG 1237
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
YT+ N G+ +V L V DKP P G +I S+T+ W DGG + Y
Sbjct: 1238 CYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 1297
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESE 1756
+IE + N W ++A ++ +Q L + EY FRV A N G SE + ESE
Sbjct: 1298 SIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 1351
Score = 74.9 bits (176), Expect = 3e-12
Identities = 51/202 (25%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXX 1539
+P+ LK+ +D L C G P P++TW +G+ ++ A++T E
Sbjct: 444 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQD 503
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQ----------------KPVITISNEDIKQ- 1582
Y C+A N G+V S V + + KP I + +
Sbjct: 504 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDL 563
Query: 1583 KHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSK 1642
K G + +T + G PPPEVIW NGN+++ ++++ + + I+E+ +
Sbjct: 564 KVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPEDTGT 623
Query: 1643 YTIEASNTAGTSSVEVTLKVYD 1664
YT EA N+AG + L V +
Sbjct: 624 YTCEAWNSAGEVRTQAVLTVQE 645
Score = 66.5 bits (155), Expect = 1e-09
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE Q AP F +KL+ H +G + +CQV P I W +K ++ F + +
Sbjct: 1022 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQE 1080
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDH 607
++ ++ I + PED G + CVAKN AG A + ++ V +AP S++
Sbjct: 1081 GSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASEN 1126
Score = 65.7 bits (153), Expect = 2e-09
Identities = 47/213 (22%), Positives = 91/213 (42%), Gaps = 8/213 (3%)
Query: 1464 ASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
+S +EY + +K +P + L ++ + +T G P P+V W +G +++
Sbjct: 536 SSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQ 595
Query: 1524 TAK-ATYENRXXXXX---XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT---IS 1576
++ +E R Y C A+N GEV T V+ +Q+ T
Sbjct: 596 ESEDFHFEQRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFI 655
Query: 1577 NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKEL 1635
++ +G L++ I G P P V W ++G L D + + E + +K++
Sbjct: 656 SKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKV 715
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ H+ +Y I N G S +V+L + + ++
Sbjct: 716 QPWHAGQYEILLKNRVGECSCQVSLMLQNSSAR 748
Score = 64.9 bits (151), Expect = 3e-09
Identities = 70/281 (24%), Positives = 122/281 (43%), Gaps = 37/281 (13%)
Query: 1010 LVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD-VVWERDGEIIKPKKNKYDFEKR 1068
L V E P F L+D V E +L+ + + W +G+ I+ ++ +
Sbjct: 438 LAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCE---- 493
Query: 1069 GHIRKLYIRNTSVHDEGEYSCI----LRDESCTAEVTVVE----------LP-------- 1106
+ +L+I++ D G Y+C+ L SC+A VTV E LP
Sbjct: 494 AGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTA 553
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P + L + KV G++ T ++++ V W +G+EIQ S G + L I
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWI 613
Query: 1166 YDCDLDDAGEYSCEVGNS----KCTAILTVEEP---SINFTLRLPEFILVPANTDAYLTV 1218
+ +D G Y+CE NS + A+LTV+EP + + + P + ++
Sbjct: 614 QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISC 673
Query: 1219 EIP-DETLDVTWYKK-KSVIEDTEKFTLISDVKKRTLIIRK 1257
I D V W + K++ +DT F ++ + TL+++K
Sbjct: 674 AIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKK 714
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 33/222 (14%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHS 788
E P I P +++ +++G + +V G P P +TW +N +P+ + L T S
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 789 ITILKPKKVKDEGVYTLKAENS------------EG----------IAET-----SAVIT 821
+ I + +D G YT +A N EG +++T SA
Sbjct: 91 LVIHAVHE-EDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAV 149
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQ 881
P+ PP F + + VKE + ++T P P +TW + N + PS ++
Sbjct: 150 ETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSV 209
Query: 882 NFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ L I V+ + D G Y C+ N +GK+S A ++I
Sbjct: 210 SEKNGMQVLEIHGVNQD-DVGVYTCLVVNGSGKASMSAELSI 250
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/200 (24%), Positives = 87/200 (43%), Gaps = 12/200 (6%)
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
+KV + + + + E+C + ++ +N +G +A V T +D P
Sbjct: 1215 MKVENSENGSKLTILAARQEHCG-CYTLLVENKLGSRQAQ-----VNLTVVDKPDPPAGT 1268
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSIN 1832
I + S+ ++W+ S +GGS + Y +EI K WK +Q L +
Sbjct: 1269 PCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD 1328
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEPES 1891
Y+FR+ A N GTS P + T+G+ P +P++ V VS+ + + +
Sbjct: 1329 HEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPKDEVEVSDDDEKEPEVDYRTVTI 1385
Query: 1892 NGGSPITN-YIIEFKTVKGK 1910
N +++ Y IE + GK
Sbjct: 1386 NTEQKVSDFYDIEERLGSGK 1405
Score = 58.0 bits (134), Expect = 3e-07
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 1262 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 1319
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
FN++DL +H Y R+ A N G SEP + E V GE EEP ++ EV
Sbjct: 1320 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTV--GE---KPEEPKDEVEV 1368
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 5/132 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + L+ + V +G+ ++L QV +P TI W N K +K + +G S++I
Sbjct: 1029 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1088
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTI 850
K +D G+Y A+N G AE S +TV++ P EN + P +R + ++
Sbjct: 1089 EKALP-EDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGT 1147
Query: 851 KLVARVTRNPVP 862
+ A V + P P
Sbjct: 1148 ESDATVKKKPAP 1159
Score = 55.2 bits (127), Expect = 2e-06
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 43/246 (17%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI--------- 680
+G P F +K + +V EG +LL+C++ + P I W G+ + + I
Sbjct: 1025 QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLC 1084
Query: 681 SVAIES----DMHMY------------CSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
SV+IE D +Y CS + E T +R ++SLP V
Sbjct: 1085 SVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPV 1144
Query: 725 L--------KIKTGEKEPP------QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK 770
L K K K PP Q+I+ + VR GESV L +V G T TW K
Sbjct: 1145 LGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMK 1204
Query: 771 NNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
K ++ + ++ + +TIL ++ + G YTL EN G + +TV + +
Sbjct: 1205 FRKQIQESEHMKVENSENGSKLTILAARQ-EHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1263
Query: 828 ENAEPP 833
A P
Sbjct: 1264 PPAGTP 1269
Score = 54.4 bits (125), Expect = 4e-06
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILK 793
PP+ L ++V++G+ S ++ G P+P +TW K N P++ S + + + +L+
Sbjct: 160 PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLE 219
Query: 794 PKKVK--DEGVYTLKAENSEGIAETSAVITVE 823
V D GVYT N G A SA ++++
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQ 251
Score = 54.0 bits (124), Expect = 6e-06
Identities = 39/152 (25%), Positives = 69/152 (45%), Gaps = 7/152 (4%)
Query: 452 NQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNE-KIDKLPVFEKPTSEEQSMAP 510
++D+ + Q+ T+ W+ + D YT E + + ++P Q P
Sbjct: 597 SEDFHFEQRG-TQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ---P 652
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ-TAIIKPSQDFQMYYDDDNVATLV 569
F+ K R G +V C + G P P + W R A+ K + F++ ++D V TLV
Sbjct: 653 WFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNED-VFTLV 711
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+++V P AG + + KN G S L+++
Sbjct: 712 LKKVQPWHAGQYEILLKNRVGECSCQVSLMLQ 743
Score = 54.0 bits (124), Expect = 6e-06
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E+ +E P F + Q++ V E + L +V+ +P +I W N + + ++ I +
Sbjct: 1019 EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILS 1078
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
+G + I E D G YKCVA N AG++ +VT+D
Sbjct: 1079 QEGSLCSVSIEKALPE-DRGLYKCVAKNDAGQAECSCQVTVD 1119
Score = 52.8 bits (121), Expect = 1e-05
Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P F +KLQD V E +L+ +++S+ A ++W +G+ +K K + G +
Sbjct: 1027 TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQEGSLCS 1085
Query: 1074 LYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
+ I D G Y C+ ++++ C+ +VTV + P T+ K + + +
Sbjct: 1086 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVL 1145
Query: 1130 LTKGDALVR 1138
T+ DA V+
Sbjct: 1146 GTESDATVK 1154
Score = 52.0 bits (119), Expect = 2e-05
Identities = 65/309 (21%), Positives = 127/309 (41%), Gaps = 35/309 (11%)
Query: 1100 VTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTID 1157
+ V+E+ P + L++ V +G + + +G + R W +G IQ++ T +
Sbjct: 438 LAVMEVAPSFSSVLKDCAVIEGQDFVLQCSV-RGTPVPRITWLLNGQPIQYARS---TCE 493
Query: 1158 GKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEE-----------------PSI 1196
+L I D +D G Y+C +G C+A +TV E P+
Sbjct: 494 AGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTA 553
Query: 1197 NFTLRLPEFILVPANTDAYLTVEIP-DETLDVTWYKKKSVIEDTEKFTLISDVKKRTLII 1255
L+ + V + +TV++ + +V W + I+++E F + +L I
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWI 613
Query: 1256 RKCTEDDQCEYTCVLLDAKSTTKLK-VEVVEFP-----PKIVDYEREYRIKRGSDVTLLV 1309
++ +D YTC ++ + + V V+ P P + R G V +
Sbjct: 614 QEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISC 673
Query: 1310 DYQAFPQPNDEWIVNSKII-KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
P P W+ + K + K H + + +L +KKV+ AG Y++ L+N G
Sbjct: 674 AIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGE 733
Query: 1369 ADVEMNVTI 1377
++++ +
Sbjct: 734 CSCQVSLML 742
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 1738 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 1795
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 1796 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 1835
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+NLK+ S + N+V+ T + E++ +P ++ L+++ + +
Sbjct: 988 ENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLL 1047
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX----XXXYKCIAFNDH 1556
L C P + W +GK LKT K ++ YKC+A ND
Sbjct: 1048 LQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDA 1107
Query: 1557 GEVETSCVVGIQQKP 1571
G+ E SC V + P
Sbjct: 1108 GQAECSCQVTVDDAP 1122
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/94 (27%), Positives = 42/94 (44%)
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL 890
E P FI + + +KE T K RV P P +TW+RN + I+ +
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS 90
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
++ + E D G Y C A+N +G +T++
Sbjct: 91 LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVE 124
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 1712 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 1771
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 1772 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 1830
Query: 924 D 924
+
Sbjct: 1831 E 1831
Score = 46.8 bits (106), Expect = 9e-04
Identities = 46/199 (23%), Positives = 83/199 (41%), Gaps = 18/199 (9%)
Query: 1013 KETIPEFIRKLQDFEVKEKDVAILEVEINSETA-DVVWERDGEIIKPKKNKYDFEKRGHI 1071
K T P F++ L D +V + + V+++ +V+W +G I+ ++ + FE+RG
Sbjct: 550 KPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESED-FHFEQRGTQ 608
Query: 1072 RKLYIRNTSVHDEGEYSCIL---RDESCTAEVTVVELP-----PEIITRLQNQKVNKGNK 1123
L+I+ D G Y+C E T V V+ P P I++ ++ + G
Sbjct: 609 HSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQS 668
Query: 1124 ATFEIELTKGDAL--VRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
+ GD V W +DG + + + H ++ + L + AG+Y
Sbjct: 669 VLISCAIA-GDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILL 727
Query: 1179 --EVGNSKCTAILTVEEPS 1195
VG C L ++ S
Sbjct: 728 KNRVGECSCQVSLMLQNSS 746
Score = 45.6 bits (103), Expect = 0.002
Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQK 1162
E PP+ T+L V +G F ++T + V W K +Q S + ++ Q
Sbjct: 158 ECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQV 217
Query: 1163 LKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
L+I+ + DD G Y+C V N A ++ E
Sbjct: 218 LEIHGVNQDDVGVYTCLVVNGSGKASMSAE 247
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 4/101 (3%)
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKD 1934
S+ S S+TL W +GGS + +Y IE K+W ++ T + ++++
Sbjct: 1272 SDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFN--VQDLLPDH 1329
Query: 1935 EIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
E FR+ A N G S P SQ L P P +E+
Sbjct: 1330 EYKFRVRAINVYGTSEP--SQESELTTVGEKPEEPKDEVEV 1368
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/88 (26%), Positives = 40/88 (45%)
Query: 1295 REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
++ + G + L + P W +N K +K K S + S++I+K D
Sbjct: 1036 QDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPED 1095
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPS 1382
G+YK +N+ G A+ VT+ D P+
Sbjct: 1096 RGLYKCVAKNDAGQAECSCQVTVDDAPA 1123
Score = 43.6 bits (98), Expect = 0.008
Identities = 58/267 (21%), Positives = 102/267 (38%), Gaps = 24/267 (8%)
Query: 1276 TTKLKVE---VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK 1332
T K + E V+E P ++ + G D L + P P W++N + I +
Sbjct: 430 TVKFRCEGLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI---Q 486
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+ + + ++ A L I+ D G Y EN G VT+ +K S +L +
Sbjct: 487 YARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPV 546
Query: 1393 DSSS----INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSS 1448
S I + + + + V+ E I + N + Q S ++
Sbjct: 547 APSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQES-EDFHFEQR 605
Query: 1449 YRFRAYAVNEVDISD-ASETTEYYKVIKETKIQSP-TVEKP-----------LKNITTEP 1495
+ + EV D + T E + E + Q+ TV++P +++T
Sbjct: 606 GTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASL 665
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ + ++C G P P V W RDGK L
Sbjct: 666 GQSVLISCAIAGDPFPTVHWLRDGKAL 692
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 1740 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1799
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 1800 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 1831
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 4/100 (4%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEK-TSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+ G P P+V W++NG + + + + + T + I + KYT EA+N +G
Sbjct: 56 VRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGAR 115
Query: 1655 SVEVTLKVYDKPSKPEG-PVIMREI-SRESVT-IEWKPPL 1691
V V L V +K G PV+ + + R S + +E +P +
Sbjct: 116 QVTVELTVEGSFAKQLGQPVVSKTLGDRFSASAVETRPSI 155
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 1763 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 1822
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 1823 TCTAELIV 1830
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 1740 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 1799
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 1800 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 1839
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/103 (22%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +LQ+ V +G K + +++ A + W +G ++ + I L+ +G + I
Sbjct: 1029 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 1088
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
+D G Y C + G ++C+ +TV++ + + PE
Sbjct: 1089 EKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 1131
Score = 34.7 bits (76), Expect = 3.7
Identities = 19/78 (24%), Positives = 32/78 (41%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
K G + I G P P+V W K L+ +++ K V+ I + + YT
Sbjct: 173 KEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYT 232
Query: 1645 IEASNTAGTSSVEVTLKV 1662
N +G +S+ L +
Sbjct: 233 CLVVNGSGKASMSAELSI 250
Score = 34.7 bits (76), Expect = 3.7
Identities = 18/89 (20%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G ++++ + G P P + W NG ++ + T + + + I++ YT
Sbjct: 459 GQDFVLQCSVRGTPVPRITWLLNGQPIQYARS---TCEAGVAELHIQDALPEDHGTYTCL 515
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIM 1675
A N G S + V++K S + ++
Sbjct: 516 AENALGQVSCSAWVTVHEKKSSRKSEYLL 544
Score = 33.9 bits (74), Expect = 6.4
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + PP +IW NG L+ K ++ + + I++ Y
Sbjct: 1043 GKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCV 1102
Query: 1647 ASNTAGTSSVEVTLKVYDKPS 1667
A N AG + + V D P+
Sbjct: 1103 AKNDAGQAECSCQVTVDDAPA 1123
Score = 33.5 bits (73), Expect = 8.5
Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 12/128 (9%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALV-RWFKDGSEIQFSNHIQLTIDGKKQKL 1163
+PP+II ++QKV G ++T + W K +IQ S H+++ KL
Sbjct: 1167 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKL 1226
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAYLTVEIPD 1222
I + G Y+ V N L + +N T + P+ PA T +I
Sbjct: 1227 TILAARQEHCGCYTLLVENK-----LGSRQAQVNLTVVDKPD---PPAGTPC--ASDIRS 1276
Query: 1223 ETLDVTWY 1230
+L ++WY
Sbjct: 1277 SSLTLSWY 1284
>AL591178-3|CAH72090.1| 1437|Homo sapiens myomesin family, member 3
protein.
Length = 1437
Score = 104 bits (249), Expect = 4e-21
Identities = 131/533 (24%), Positives = 218/533 (40%), Gaps = 73/533 (13%)
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLE----NDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
L+T ++ PPP+V WYKN +++ +Y IT + I+ S+ YT+
Sbjct: 172 LLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDSATYTVR 231
Query: 1647 ASNTAGTSS--VEVTLKVY-DKPSKPEGPVIMREISRESV--TIEWKPPL--DDGGLELT 1699
N G +S +V ++ Y K + + + R SV T KP + L+
Sbjct: 232 VKNAHGQASSFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLS 291
Query: 1700 -KYAIEKHEPDNNRWI------------KVADVDRD--VETYCIQKLNENCEYMFRVIAQ 1744
++ + + ++ +W K+ DR ++ C K +E YM RV
Sbjct: 292 CLFSEDVLDAESIQWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGL-YMVRV--- 347
Query: 1745 NPVGFSEALESEPIVIKTA-LDVPSXXXXXXXXXXID--NESVYITWFPSEKNGGSPIID 1801
P F +S ++++ A + P +D + + +TW P G+PI
Sbjct: 348 -PSPFGPREQSTYVLVRDAEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITA 406
Query: 1802 YKVEIKQ-EGKKWKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTS---------- 1848
Y +E Q E +W R IQ L +Y+FR+ A + +G+S
Sbjct: 407 YTIERCQGESGEWIACHEAPGGTCRCPIQGLVEGQSYRFRVRAISRVGSSVPSKASELVV 466
Query: 1849 ------------LPYTSDDKITIGK-----TLTPPSQPRNFVVSESTSRSVTLKWTEPES 1891
+P+ +KITI T+T PS P N SE V L W EP
Sbjct: 467 MGDHDAARRKTEIPFDLGNKITISTDAFEDTVTIPSPPTNVHASEIREAYVVLAWEEPSP 526
Query: 1892 NGGSPITNYIIEFKTVKGKSWTKIVTVGG-SVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
+P+T Y +E + +W I + + ++++K +FR+ A N G+S
Sbjct: 527 RDRAPLT-YSLEKSVIGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSD 585
Query: 1951 PTE-SQSVRLE-KHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDV 2008
P+E S+ + L AT+P PP R +++ +T W P D LLGY I R V
Sbjct: 586 PSEPSEPIALRGPPATLP-PPAQVQAFRDTQTSVSLT-W-DPVKD--PELLGYYIYSRKV 640
Query: 2009 TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
+ W V + +F + L Y + + +E G+ E + EP +V
Sbjct: 641 GTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVGESSAATEPIRV 693
Score = 83.8 bits (198), Expect = 6e-15
Identities = 80/332 (24%), Positives = 130/332 (39%), Gaps = 16/332 (4%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTS-----SVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+ +L++ S + + A N G S S + L+ P V ++ SV++
Sbjct: 562 VLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQTSVSLT 621
Query: 1687 WKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNP 1746
W P D EL Y I + + W V + + + L EY F V + +
Sbjct: 622 WDPVKDP---ELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSE 678
Query: 1747 VGFSEA-LESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE 1805
G E+ +EPI +K AL PS NE V I W P ++ GG I+ Y ++
Sbjct: 679 AGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEMV-IGWKPPKRRGGGKILGYFLD 737
Query: 1806 IKQ-EGKKWKXXXXXX--XXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK- 1861
E W ++ L Y+FR A N G +
Sbjct: 738 QHDSEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEW 797
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
T+ P P + SE + S+ L+W P G P+T Y + F+ + W K VT G
Sbjct: 798 TMPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQW-KPVTPGPI 856
Query: 1922 VHEHC-IENIKEKDEIIFRISAENTVGVSLPT 1952
H + +++ +F++ A N+ G+ P+
Sbjct: 857 SGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPS 888
Score = 70.5 bits (165), Expect = 6e-11
Identities = 56/222 (25%), Positives = 93/222 (41%), Gaps = 11/222 (4%)
Query: 1834 TYQFRIYARNEIGTSLPYTSDDKITIG---KTLTPPSQPRNFVVSESTSRSVTLKWTEPE 1890
+Y FR+ A N+ G S P + I + TL PP+Q + F T SV+L W +P
Sbjct: 570 SYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAF---RDTQTSVSLTW-DPV 625
Query: 1891 SNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
+ + Y I + V W + + ++ E F + + + GV
Sbjct: 626 KD--PELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVGE 683
Query: 1951 PTES-QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVT 2009
+ + + +R+++ PS P + G N ++ W P+ GG +LGY + D
Sbjct: 684 SSAATEPIRVKQALATPSAPYG-FALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSE 742
Query: 2010 KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSE 2051
+ W V + + T + DL E H Y R A N G+ E
Sbjct: 743 ELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGE 784
Score = 64.1 bits (149), Expect = 5e-09
Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 36/279 (12%)
Query: 1227 VTWYKKKSVIED----TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA--KSTTKLK 1280
VTWYK + I+ K+ + ++ +L IR+C +D YT + +A ++++ K
Sbjct: 185 VTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDSATYTVRVKNAHGQASSFAK 244
Query: 1281 VEVVEFPPKIVDYEREY---------------------RIKRGSDVTLLVDYQAFPQPND 1319
V V + K ++ E R K ++ L +
Sbjct: 245 VLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLSCLFSEDVLDAESI 304
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
+W + +++ + K + ASL + D G+Y +R+ + G + V + D
Sbjct: 305 QWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYMVRVPSPFGPREQSTYVLVRD 364
Query: 1380 ----KPSPPGKP-NI--LEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN 1432
P PG P N+ L+++ + + W P +T + I Y +E + ++ EWI+
Sbjct: 365 AEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWIACHE 424
Query: 1433 IT--KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ IQ L SYRFR A++ V S S+ +E
Sbjct: 425 APGGTCRCPIQGLVEGQSYRFRVRAISRVGSSVPSKASE 463
Score = 61.7 bits (143), Expect = 3e-08
Identities = 48/215 (22%), Positives = 81/215 (37%), Gaps = 6/215 (2%)
Query: 1649 NTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
++A T + V + PS P G ++ + + I WKPP GG ++ Y +++H+
Sbjct: 684 SSAATEPIRVK-QALATPSAPYGFALLN-CGKNEMVIGWKPPKRRGGGKILGYFLDQHDS 741
Query: 1709 DNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPS 1768
+ W V + L+E Y FR A N G E + +P
Sbjct: 742 EELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEWTMPQ 801
Query: 1769 -XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWK--XXXXXXXXXA 1824
+ S+ + W P G P+ Y V ++EG ++WK
Sbjct: 802 PGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISGTHL 861
Query: 1825 RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
R+ L +Y F++ A N G P D + +
Sbjct: 862 RVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLL 896
Score = 48.0 bits (109), Expect = 4e-04
Identities = 33/98 (33%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN---VA 566
P F LR + +TV C V+ P PQ+TW++ I P Y N +
Sbjct: 154 PWFWIPLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLL 213
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
+L IR ED+ T+T KNA G ASS +++V L
Sbjct: 214 SLEIRRCAIEDSATYTVRVKNAHGQASSFAKVLVRTYL 251
Score = 46.8 bits (106), Expect = 9e-04
Identities = 30/141 (21%), Positives = 67/141 (47%), Gaps = 11/141 (7%)
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMN---VTILDKPS---PPGKPNILEIDS 1394
+S + +E + ++++R N G +D + + P+ PP +
Sbjct: 556 RSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQ 615
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFR 1452
+S+++ WD ++ ++ Y + +++ T+EW +V N I T+ ++ L+T Y F
Sbjct: 616 TSVSLTWDPVKDP---ELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFC 672
Query: 1453 AYAVNEVDISDASETTEYYKV 1473
+V+E + ++S TE +V
Sbjct: 673 VRSVSEAGVGESSAATEPIRV 693
Score = 46.4 bits (105), Expect = 0.001
Identities = 52/205 (25%), Positives = 88/205 (42%), Gaps = 21/205 (10%)
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKK 796
PLK +G + + TW +K +++ + T + D + IL PK
Sbjct: 1226 PLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKRLESGDRIRTGTTLDEIWLHILDPKD 1285
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE----PPLFI---NRFQEI------- 842
D+G YTL+ + + + S ++ + + AE L I NR + +
Sbjct: 1286 -SDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEHQRLKTLAIIEKNRAKVVRGLPDVA 1344
Query: 843 TVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSG 902
T+ E T+ L V+ +P P I+W +N++ ++ + G + + I V+SE DSG
Sbjct: 1345 TIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVTITIEKVNSE-DSG 1403
Query: 903 DYKCVASNSAGKSSHGARVTIDVEK 927
Y N G S +VTI V K
Sbjct: 1404 RYGVFVKNKYG--SETGQVTISVFK 1426
Score = 46.0 bits (104), Expect = 0.001
Identities = 25/92 (27%), Positives = 47/92 (51%), Gaps = 4/92 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
PSPP + EI + + + W+EP + + Y +E I + W ++ + + +
Sbjct: 501 PSPPTNVHASEIREAYVVLAWEEPSPRDRAPLT-YSLEKSVIGSGTWEAISSESPVRSPR 559
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
++ +L+ SY FR A+N+ +SD SE +E
Sbjct: 560 FAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSE 591
Score = 45.2 bits (102), Expect = 0.003
Identities = 91/398 (22%), Positives = 151/398 (37%), Gaps = 55/398 (13%)
Query: 458 VQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDKL--PVFEKPTSEEQSMAPIFVEK 515
+Q E+KG AQ L D Q +++ DKL K ++ P F
Sbjct: 1067 IQNLSEEDKGSYTAQ-LQDGKAKNQITLTLVDDDFDKLLRKADAKRRDWKRKQGPYFERP 1125
Query: 516 LRPKHTPDGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVF 574
L+ K T D VQ C+V + + WF Q A + Q Y + L I E+
Sbjct: 1126 LQWKVTED-CQVQLTCKVTNTKKETRFQWFFQRAEMPDGQ----YDPETGTGLLCIEELS 1180
Query: 575 PEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPP 634
+D G + + + D G + T+ ++ G
Sbjct: 1181 KKDKGIYRAMVSD------------------DRGEDDTILDLTGDALDAIFTEL--GRIG 1220
Query: 635 TFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
S P K Q +EG I + + + W K + + + I D
Sbjct: 1221 ALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKRLESGDRIRTGTTLDEIW--- 1277
Query: 694 VLKITNVKKFQEGTYTV-VAVNRE---------GEA---SLPIVLKIKTG---EKEPPQV 737
L I + K +G YT+ +A +E G+A ++ ++KT EK +V
Sbjct: 1278 -LHILDPKDSDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEHQRLKTLAIIEKNRAKV 1336
Query: 738 IEPLKSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILK 793
+ L + + + +++ L+ V G+P P I+W KN++PV L + G +ITI K
Sbjct: 1337 VRGLPDVATIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVTITIEK 1396
Query: 794 PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+D G Y + +N G I+V + +E E
Sbjct: 1397 VNS-EDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKE 1433
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/94 (24%), Positives = 45/94 (47%), Gaps = 2/94 (2%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITK 1435
+ +P PP E+ ++S+ + W+ P G + Y V +QE + +W ++ I+
Sbjct: 799 MPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISG 858
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
T + +L+ SY F+ A+N + S T+
Sbjct: 859 THLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTD 892
Score = 44.4 bits (100), Expect = 0.005
Identities = 19/79 (24%), Positives = 38/79 (48%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+T ++ G P PE+ W KN + Y + + I I+++ S +Y + N
Sbjct: 1354 LTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKY 1413
Query: 1652 GTSSVEVTLKVYDKPSKPE 1670
G+ + +VT+ V+ +P+
Sbjct: 1414 GSETGQVTISVFKHGDEPK 1432
Score = 41.5 bits (93), Expect = 0.032
Identities = 37/167 (22%), Positives = 67/167 (40%), Gaps = 12/167 (7%)
Query: 1320 EW-IVNSKIIKKCKHTKPSIDS-KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
EW VN+K I+ + T P + + K ++ V G E++ + +
Sbjct: 644 EWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVG------ESSAATEPIRVKQA- 696
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITK 1435
L PS P +L + + I W P+ G I+ Y ++ + + +W +V I
Sbjct: 697 LATPSAPYGFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHAVNQQPIPT 756
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP 1482
+ +L Y FRA A N + + S + ++ KE + P
Sbjct: 757 RVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFE-CKEWTMPQP 802
Score = 37.9 bits (84), Expect = 0.39
Identities = 22/89 (24%), Positives = 47/89 (52%), Gaps = 6/89 (6%)
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSD----GDTHSITILKPK 795
PL+S V + +V+L+ V +P P +TW KN+ + ++ + + + L+ +
Sbjct: 159 PLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIR 218
Query: 796 K--VKDEGVYTLKAENSEGIAETSAVITV 822
+ ++D YT++ +N+ G A + A + V
Sbjct: 219 RCAIEDSATYTVRVKNAHGQASSFAKVLV 247
Score = 37.5 bits (83), Expect = 0.52
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 9/97 (9%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISP------SETITQNFDGE 886
P F + V E T+ L V +P P +TWY+N+ I P IT N+
Sbjct: 154 PWFWIPLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLL 213
Query: 887 NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
++E+ ++ DS Y N+ G++S A+V +
Sbjct: 214 SLEIRRCAIE---DSATYTVRVKNAHGQASSFAKVLV 247
Score = 34.3 bits (75), Expect = 4.9
Identities = 32/184 (17%), Positives = 75/184 (40%), Gaps = 22/184 (11%)
Query: 1223 ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
E + TW+ K +E ++ + + + L I + D+ +YT + K +L +
Sbjct: 1248 EYMKTTWFHKDKRLESGDRIRTGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEVRQLSTD 1307
Query: 1283 VV--EFPPKIVDYER----------EYRIKRG-SDVTLLVDYQAF---------PQPNDE 1320
+ F + +++R ++ RG DV +++ + P P
Sbjct: 1308 LSGQAFEDAMAEHQRLKTLAIIEKNRAKVVRGLPDVATIMEDKTLCLTCIVSGDPTPEIS 1367
Query: 1321 WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
W+ N + + + + ++TI+KV + D+G Y + ++N G ++ +++
Sbjct: 1368 WLKNDQPVTFLDRYRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKYGSETGQVTISVFKH 1427
Query: 1381 PSPP 1384
P
Sbjct: 1428 GDEP 1431
>BC036524-1|AAH36524.1| 772|Homo sapiens DCC protein protein.
Length = 772
Score = 103 bits (248), Expect = 5e-21
Identities = 123/585 (21%), Positives = 221/585 (37%), Gaps = 34/585 (5%)
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXX 1541
+++P + E + + C+ G P P TW R + +L++ K +
Sbjct: 177 LQRPSNVVAIEGKDAVLEGCV-SGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVT 235
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C+ + + S + + P ++ + E+ T + G P
Sbjct: 236 DDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECT--VSGKPV 293
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P V W KNG+ + + I S +RI + +S Y A N AG + L
Sbjct: 294 PTVNWMKNGDVVIPSDYFQIV---GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQL- 349
Query: 1662 VYDKPSKPEGPVIMRE--------ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW 1713
+ KP+ P V+ +S V + W+PP + G T E DN
Sbjct: 350 IVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRER 409
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
++ + L Y FRV+A N G E+ + + + L VP
Sbjct: 410 ALNTTQPGSLQ-LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENL 468
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINT 1833
S+ ITW P G P+ Y++ + + +++ L T
Sbjct: 469 QAVST-SPTSILITWEPPAYANG-PVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFT 526
Query: 1834 TYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNG 1893
Y R A N G + ++DD + + P + P+N + SRS+ + W P S
Sbjct: 527 EYSLRFLAYNRYGPGV--STDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT 584
Query: 1894 GSP-ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
+ IT Y I + + ++ T+ + + +++ + F++SA G P+
Sbjct: 585 QNGFITGYKIRHRKTTRRG--EMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPS 642
Query: 1953 ESQSVRLEKH----ATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDV 2008
+ ++ + VP P++ L +R +N ++ SW TP + + GY I
Sbjct: 643 NWYTAETPENDLDESQVPDQPSS-LHVR-PQTNCIIMSW-TPPLNPNIVVRGYIIGYG-- 697
Query: 2009 TKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
+ + E +VD ++I L + Y+I + A N G PL
Sbjct: 698 VGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPL 742
Score = 90.2 bits (214), Expect = 7e-17
Identities = 150/723 (20%), Positives = 265/723 (36%), Gaps = 50/723 (6%)
Query: 1263 QCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEW 1321
QCE + L D+ S +V V P + + G V L + P P W
Sbjct: 50 QCEAS--LGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHW 107
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCG-HADVEMNVTILDK 1380
N + + + S +L I +++ D GIY+ N E V IL
Sbjct: 108 QKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSD 167
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSI 1440
P + L+ S+ + I G ++ V + W+ + + + ++
Sbjct: 168 PGLHRQLYFLQRPSNVVAI-------EGKDAVLEGCVSGYPPPSFTWLRGEEVIQLRSKK 220
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE---TKIQSPTVEKPLKNITTEPNE 1497
+L S+ ++ + T + + T + P N+ +
Sbjct: 221 YSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESM 280
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKK-LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDH 1556
DIE C G P P V W ++G + + Y+C+A N+
Sbjct: 281 DIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEA 340
Query: 1557 GEVETSCVVGIQQKPVITISN------EDIK----QKHKVGDEWLVTAVIEG-IPPPEVI 1605
G +TS + I KP I S+ D+ V W A +G I V
Sbjct: 341 GNAQTSAQL-IVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVF 399
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
+ + G+ E + N TT+ + + + LK + + A N G +KV +
Sbjct: 400 FSREGDNRE--RALN-TTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQ 456
Query: 1666 PS-KPEGPVI-MREISRE--SVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
P + GPV ++ +S S+ I W+PP G + Y + E K +++
Sbjct: 457 PELQVPGPVENLQAVSTSPTSILITWEPPAYANG-PVQGYRLFCTEVSTG---KEQNIEV 512
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDN 1781
D +Y ++ L + EY R +A N G + ++ I + T DVPS +++
Sbjct: 513 DGLSYKLEGLKKFTEYSLRFLAYNRYG--PGVSTDDITVVTLSDVPSAPPQNVSLEVVNS 570
Query: 1782 ESVYITWFPSEKNGGSPII-DYKVEIKQEGKKWKXXXXXXXXXARI-QKLSINTTYQFRI 1839
S+ ++W P + I YK+ ++ ++ + + L + Y F++
Sbjct: 571 RSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQV 630
Query: 1840 YARNEIGTSLP---YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
A GT P YT++ P QP + V T+ + + WT P N
Sbjct: 631 SAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTN-CIIMSWT-PPLNPNIV 688
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT-ESQ 1955
+ YII + G + + V V + IE ++ + + A N G +P ES
Sbjct: 689 VRGYIIGYGV--GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESA 746
Query: 1956 SVR 1958
+ R
Sbjct: 747 TTR 749
Score = 81.4 bits (192), Expect = 3e-14
Identities = 67/280 (23%), Positives = 118/280 (42%), Gaps = 20/280 (7%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G +LL+C ++ P P I W +++ P S + + L+I+ ++ G
Sbjct: 88 GDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVV----LPSGALQISRLQPGDIGI 143
Query: 708 YTVVAVN----REGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
Y A N R G + +L G ++ +++ +G+ +L V G P
Sbjct: 144 YRCSARNPASSRTGNEAEVRILS-DPGLHRQLYFLQRPSNVVAIEGKDAVLEGCVSGYPP 202
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
P+ TW + + ++ K S ++ D G+YT SA +TV
Sbjct: 203 PSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTV- 261
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
PP F+N + E I+ V+ PVP++ W +N +++ PS+ Q
Sbjct: 262 ------LVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYF-QIV 314
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
G N+ ++ V S D G Y+CVA N AG + A++ +
Sbjct: 315 GGSNLR-ILGVVKS--DEGFYQCVAENEAGNAQTSAQLIV 351
Score = 77.0 bits (181), Expect = 7e-13
Identities = 83/326 (25%), Positives = 129/326 (39%), Gaps = 21/326 (6%)
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
K EG Y A G++ I K P + + +S+ G++V+L +V+G
Sbjct: 43 KPDEGLYQCEA--SLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGE 100
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAENSEGIAETSAV 819
P PTI W KN + + +P S L+ +++ D G+Y A N + T
Sbjct: 101 PMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS-SRTGNE 159
Query: 820 ITVEEPTEENAEPPL-FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSET 878
V ++ L F+ R + E L V+ P PS TW R E+I
Sbjct: 160 AEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLEGCVSGYPPPSFTWLRGEEVIQLRSK 219
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
G N L+I+NV + DSG Y CV + S A +T+ V F+ H Y
Sbjct: 220 KYSLLGGSN--LLISNVTDD-DSGMYTCVVTYKNENISASAELTVLVPP-WFLNHPSNLY 275
Query: 939 ETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
E + EC S + W N + D+ +I+ D G
Sbjct: 276 -AYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV---GGSNLRILGVVKSDEGF 331
Query: 997 IKCIVKDQ----ETSTMLVV-KETIP 1017
+C+ +++ +TS L+V K IP
Sbjct: 332 YQCVAENEAGNAQTSAQLIVPKPAIP 357
Score = 71.3 bits (167), Expect = 3e-11
Identities = 80/302 (26%), Positives = 115/302 (38%), Gaps = 35/302 (11%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G TV +C+V G P P I W + + P + A L I + P D G + C
Sbjct: 88 GDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGA-LQISRLQPGDIGIYRC 146
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
A+N A +S T LSD G + F ++P
Sbjct: 147 SARNPA--SSRTGNEAEVRILSDPGLHRQLY---------------------FLQRPSNV 183
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
EG D +LE + P P WL +GEE++ + ++ + S L I+NV
Sbjct: 184 VAIEGKDAVLEGCVSGYPPPSFTWL-RGEEVIQLRSKKYSL-----LGGSNLLISNVTDD 237
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
G YT V + S L + PP + ++ + + V G P
Sbjct: 238 DSGMYTCVVTYKNENISASAELTVLV----PPWFLNHPSNLYAYESMDIEFECTVSGKPV 293
Query: 764 PTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
PT+ W KN V ++ IL K DEG Y AEN G A+TSA + V
Sbjct: 294 PTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVK-SDEGFYQCVAENEAGNAQTSAQLIVP 352
Query: 824 EP 825
+P
Sbjct: 353 KP 354
Score = 68.1 bits (159), Expect = 3e-10
Identities = 95/443 (21%), Positives = 174/443 (39%), Gaps = 42/443 (9%)
Query: 1083 DEGEYSC--ILRDE----SCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL 1136
DEG Y C L D S TA+V V P +++ ++ G+ + E+ G+ +
Sbjct: 45 DEGLYQCEASLGDSGSIISRTAKVAVAG-PLRFLSQTESVTAFMGDTVLLKCEVI-GEPM 102
Query: 1137 --VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA------I 1188
+ W K+ ++ + L+I D G Y C N + +
Sbjct: 103 PTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEV 162
Query: 1189 LTVEEPSIN---FTLRLPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIE-DTEKFT 1243
+ +P ++ + L+ P ++ DA L + TW + + VI+ ++K++
Sbjct: 163 RILSDPGLHRQLYFLQRPSNVVAIEGKDAVLEGCVSGYPPPSFTWLRGEEVIQLRSKKYS 222
Query: 1244 LISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRG 1302
L+ L+I T+DD YTCV+ E+ V PP +++
Sbjct: 223 LLGG---SNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYES 279
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
D+ P P W+ N ++ + + S +L I V +D G Y+
Sbjct: 280 MDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGS---NLRILGVVKSDEGFYQCVA 336
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNI---------LEIDSSSINICWDEPENTGNSTII 1413
EN G+A + I+ KP+ P + + + S + + W P +
Sbjct: 337 ENEAGNAQTSAQL-IVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQT 395
Query: 1414 YYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
+ V +E D E ++ Q ++ NLK + Y FR A NE E+++ K
Sbjct: 396 FTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNE---WGPGESSQPIK 452
Query: 1473 VIKETKIQSPTVEKPLKNITTEP 1495
V + ++Q P + L+ ++T P
Sbjct: 453 VATQPELQVPGPVENLQAVSTSP 475
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/94 (31%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+ + + ++FEC V G P P + W + ++ PS FQ+ + L
Sbjct: 265 PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV----GGSNLR 320
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
I V D G + CVA+N AG A ++ +LIV P
Sbjct: 321 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP 354
Score = 39.9 bits (89), Expect = 0.098
Identities = 25/81 (30%), Positives = 34/81 (41%), Gaps = 3/81 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G E V GYP P TW R +I+ N L+I V +D+G +T
Sbjct: 187 EGKDAVLEGCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSN---LLISNVTDDDSGMYT 243
Query: 583 CVAKNAAGFASSTTELIVEAP 603
CV S++ EL V P
Sbjct: 244 CVVTYKNENISASAELTVLVP 264
>AY603755-1|AAT80901.1| 3094|Homo sapiens striated muscle
preferentially expressed protein protein.
Length = 3094
Score = 103 bits (247), Expect = 7e-21
Identities = 112/449 (24%), Positives = 185/449 (41%), Gaps = 38/449 (8%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
EE AP+F L+ G+ V +C + P PQ++W + + ++ S+ + +
Sbjct: 587 EEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALR-SEGRLLLRAEG 645
Query: 564 NVATLVIREVFPEDAGTF-----------TCVAK-------NAAGFASSTT---ELIV-- 600
TL++RE DAG++ TC A + + F+S T E +
Sbjct: 646 ERHTLLLREARAADAGSYMATATNELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPP 705
Query: 601 -EAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVA 659
E P T +D PPTF Q V EG D+++ R+
Sbjct: 706 EEFPEPGETWPRTPTMKPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQG 765
Query: 660 IPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEA 719
P+P ++WL + + PD+ A E++ + C L+I ++ G YT AVN G
Sbjct: 766 EPKPVVSWLRNRQPVRPDQR-RFAEEAEGGL-CR-LRILAAERGDAGFYTCKAVNEYGAR 822
Query: 720 SLPIVLKIKT-GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW-CKNNKPVKA 777
L+++ E V+ PL+ + V GE + V G + W C+ A
Sbjct: 823 QCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPA 882
Query: 778 -LPTKSDGDTHSITILKPKKVKDE-GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLF 835
L K D +L +D+ GVYT K ++ SA +TV + PLF
Sbjct: 883 LLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRP-----SLAPLF 937
Query: 836 INRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV 895
+++ V E + +++ P P +TW + SE + DG L I +V
Sbjct: 938 TRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHV 997
Query: 896 DSEIDSGDYKCVASNSAGKSSHGARVTID 924
SE D G Y A N+ G++ A++ ++
Sbjct: 998 GSE-DEGLYAVSAVNTHGQAHCSAQLYVE 1025
Score = 91.9 bits (218), Expect = 2e-17
Identities = 69/259 (26%), Positives = 115/259 (44%), Gaps = 13/259 (5%)
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV----KALPTKSDG 784
TG K PP L VR+G+ VI+S +V G P+P ++W +N +PV + +++G
Sbjct: 734 TGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEG 793
Query: 785 DTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITV 844
+ IL ++ D G YT KA N G + A + V E + L Q++ V
Sbjct: 794 GLCRLRILAAER-GDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVL--APLQDVDV 850
Query: 845 KEKGTIKLVARVTRNPVP-SITWYRNNEIISPS-ETITQNFDGENIELVITNVDSEIDSG 902
G + L + P + W ++ P+ +FDG +L++T+V E DSG
Sbjct: 851 -GAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSV-HEDDSG 908
Query: 903 DYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKW 960
Y C S + + + AR+T+ L + E EG+ +C+ S T W
Sbjct: 909 VYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTW 968
Query: 961 YHNKKEISGMDHREIIQEG 979
H + ++ + Q+G
Sbjct: 969 THFGCPMEESENLRLRQDG 987
Score = 75.4 bits (177), Expect = 2e-12
Identities = 61/250 (24%), Positives = 102/250 (40%), Gaps = 7/250 (2%)
Query: 487 KLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
KL+ D+L + T S+AP+F L +G +F+C++ G P P +TW
Sbjct: 913 KLSTAKDELTCSARLTVRP-SLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHF 971
Query: 547 TAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
++ S++ ++ D + +L I V ED G + A N G A + +L VE P +
Sbjct: 972 GCPMEESENLRL-RQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTA 1030
Query: 607 HGSEMTVXXXXXXXXXXXXADILEGIP-PTFSKKPKAQYVDEGSDILLECRLVAIPEPDI 665
+ LE + P F + + V + +LEC++ +P P I
Sbjct: 1031 ASGPSSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTI 1090
Query: 666 AWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVL 725
+W G I ++ + D+H L V G Y V N+ G+A+ L
Sbjct: 1091 SWFHNGHRIQSSDDRRMTQYRDVHR----LVFPAVGPQHAGVYKSVIANKLGKAACYAHL 1146
Query: 726 KIKTGEKEPP 735
+ PP
Sbjct: 1147 YVTDVVPGPP 1156
Score = 73.7 bits (173), Expect = 6e-12
Identities = 75/302 (24%), Positives = 122/302 (40%), Gaps = 40/302 (13%)
Query: 645 VDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM---YCSVLKITNVK 701
V G L EC + + ++ WL +G + P ++ MH C +L +T+V
Sbjct: 850 VGAGEMALFECLVAGPTDVEVDWLCRGRLLQP-----ALLKCKMHFDGRKCKLL-LTSVH 903
Query: 702 KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
+ G YT + E + L ++ P L+ + V +G + ++ G
Sbjct: 904 EDDSGVYTCKLSTAKDELTCSARLTVRPSLA--PLFTRLLEDVEVLEGRAARFDCKISGT 961
Query: 762 PRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
P P +TW P++ L + DG HS+ I +DEG+Y + A N+ G A SA
Sbjct: 962 PPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGS-EDEGLYAVSAVNTHGQAHCSA 1020
Query: 819 VITVEEPTEENAEP------------------------PLFINRFQEITVKEKGTIKLVA 854
+ VEEP + P P F+ Q++ V L
Sbjct: 1021 QLYVEEPRTAASGPSSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLAKEAMLEC 1080
Query: 855 RVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGK 914
+VT P P+I+W+ N I S+ + LV V + +G YK V +N GK
Sbjct: 1081 QVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQ-HAGVYKSVIANKLGK 1139
Query: 915 SS 916
++
Sbjct: 1140 AA 1141
Score = 73.7 bits (173), Expect = 6e-12
Identities = 74/371 (19%), Positives = 137/371 (36%), Gaps = 18/371 (4%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMN 1374
P P W N I+ + + L V AG+YK + N G A +
Sbjct: 1086 PYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAH 1145
Query: 1375 VTILDK-PSPP-GKPNILEIDSSSINICWDEPENTG---NSTIIYYVVEYQEIDTTEWIS 1429
+ + D P PP G P ++ + + + W+ P + + + Y V++Q + + +W +
Sbjct: 1146 LYVTDVVPGPPDGAPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTA 1205
Query: 1430 -VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE--TKIQSPTVEK 1486
V + + + L+ + FR + S S +E ++++ T ++P +
Sbjct: 1206 LVTGLREPGWAATGLRKGVQHIFRVLSTTVKSSSKPSPPSEPVQLLEHGPTLEEAPAMLD 1265
Query: 1487 PLKNITTEPNEDIELTCIFGGVPQPKVTWYR-DGKKLKTAKATYE------NRXXXXXXX 1539
+ + +T F V + +V W G L+ YE ++
Sbjct: 1266 KPDIVYVVEGQPASVTVTFNHV-EAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICR 1324
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGI 1599
C A N HG S + + + P ED++ G+ V+EG
Sbjct: 1325 VSRRDMGALTCTARNRHGTQTCSVTLELAEAPRFESIMEDVEVG--AGETARFAVVVEGK 1382
Query: 1600 PPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT 1659
P P+++WYK+ L + +E + + YT A N AG S +
Sbjct: 1383 PLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAE 1442
Query: 1660 LKVYDKPSKPE 1670
L V+ + E
Sbjct: 1443 LAVHSAQTAME 1453
Score = 70.1 bits (164), Expect = 8e-11
Identities = 73/267 (27%), Positives = 112/267 (41%), Gaps = 18/267 (6%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLY 1075
P F L D V+E I+ + + E VV W R+ + ++P + ++ E G + +L
Sbjct: 740 PTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLR 799
Query: 1076 IRNTSVHDEGEYSCILRDE----SCTAEVTVVELPPE----IITRLQNQKVNKGNKATFE 1127
I D G Y+C +E C A + V P ++ LQ+ V G A FE
Sbjct: 800 ILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFE 859
Query: 1128 IELTKG--DALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSK 1184
L G D V W G +Q + ++ DG+K KL + DD+G Y+C++ +K
Sbjct: 860 C-LVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAK 918
Query: 1185 ----CTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKSVIEDT 1239
C+A LTV RL E + V A +I VTW +E++
Sbjct: 919 DELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEES 978
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEY 1266
E L D +L I +D+ Y
Sbjct: 979 ENLRLRQDGGLHSLHIAHVGSEDEGLY 1005
Score = 60.1 bits (139), Expect = 9e-08
Identities = 31/98 (31%), Positives = 46/98 (46%), Gaps = 1/98 (1%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
E + AP F + G T +F VEG P P I W++ ++ S Y ++N
Sbjct: 1351 ELAEAPRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVY-EEN 1409
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+LV+ +D G +TC A+N AG S EL V +
Sbjct: 1410 ECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVHS 1447
Score = 58.0 bits (134), Expect = 3e-07
Identities = 42/156 (26%), Positives = 74/156 (47%), Gaps = 16/156 (10%)
Query: 780 TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRF 839
++ D D + + I + + +D G T A N G +T +V T E AE P F +
Sbjct: 1311 SQPDDDQYCLRICRVSR-RDMGALTCTARNRHG-TQTCSV------TLELAEAPRFESIM 1362
Query: 840 QEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEI 899
+++ V T + V P+P I WY++ +++ S ++ ++ LV+ + ++
Sbjct: 1363 EDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQ- 1421
Query: 900 DSGDYKCVASNSAGKSS-------HGARVTIDVEKV 928
D G Y C A N AG+ S H A+ ++VE V
Sbjct: 1422 DGGVYTCTAQNLAGEVSCKAELAVHSAQTAMEVEGV 1457
Score = 51.6 bits (118), Expect = 3e-05
Identities = 29/101 (28%), Positives = 54/101 (53%), Gaps = 6/101 (5%)
Query: 727 IKTGEK--EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTK 781
+ GE+ E P PL++++V G V+L + NP P ++W K+ +++ L +
Sbjct: 583 VSAGEEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLR 642
Query: 782 SDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
++G+ H++ +L+ + D G Y A N G A +A +TV
Sbjct: 643 AEGERHTL-LLREARAADAGSYMATATNELGQATCAASLTV 682
Score = 50.4 bits (115), Expect = 7e-05
Identities = 36/175 (20%), Positives = 78/175 (44%), Gaps = 6/175 (3%)
Query: 1589 EWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEAS 1648
E ++ + G+P P + W+ NG+++++ + +T + + H+ Y +
Sbjct: 1075 EAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIA 1134
Query: 1649 NTAGTSSVEVTLKVYD-KPSKPEGPVIMREISRESVTIEWKPP--LDDG-GLELTKYAIE 1704
N G ++ L V D P P+G + ++ VT+ W PP LD + Y ++
Sbjct: 1135 NKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTYTVQ 1194
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPI 1758
+++W + R+ + L + +++FRV++ S+ + SEP+
Sbjct: 1195 HQVLGSDQWTALVTGLRE-PGWAATGLRKGVQHIFRVLSTTVKSSSKPSPPSEPV 1248
Score = 49.2 bits (112), Expect = 2e-04
Identities = 19/62 (30%), Positives = 34/62 (54%)
Query: 1463 DASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
+ + + Y E +++P E PL+N+ P D+ L CI P P+V+W++DG L
Sbjct: 574 ELESSDDSYVSAGEEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSAL 633
Query: 1523 KT 1524
++
Sbjct: 634 RS 635
Score = 49.2 bits (112), Expect = 2e-04
Identities = 64/280 (22%), Positives = 102/280 (36%), Gaps = 19/280 (6%)
Query: 552 PSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEM 611
P + M D D++ V +V D T G+A++ V+ +
Sbjct: 1176 PPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPGWAATGLRKGVQHIFRVLST-- 1233
Query: 612 TVXXXXXXXXXXXXADILEGIP-----PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIA 666
TV +LE P P KP YV EG + + E +
Sbjct: 1234 TVKSSSKPSPPSEPVQLLEHGPTLEEAPAMLDKPDIVYVVEGQPASVTVTFNHV-EAQVV 1292
Query: 667 WLF-KGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVL 725
W +G + + + D YC L+I V + G T A NR G + + L
Sbjct: 1293 WRSCRGALLEARAGVYELSQPDDDQYC--LRICRVSRRDMGALTCTARNRHGTQTCSVTL 1350
Query: 726 KIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKS--- 782
++ E P+ ++ + V GE+ + V G P P I W K+ + S
Sbjct: 1351 ELA----EAPRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVY 1406
Query: 783 DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
+ + S+ +L +D GVYT A+N G A + V
Sbjct: 1407 EENECSLVVLS-TGAQDGGVYTCTAQNLAGEVSCKAELAV 1445
Score = 48.8 bits (111), Expect = 2e-04
Identities = 41/177 (23%), Positives = 74/177 (41%), Gaps = 10/177 (5%)
Query: 1014 ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWER-DGEIIKPKKNKYDFEKRGHIR 1072
E P + K V E A + V N A VVW G +++ + Y+ + +
Sbjct: 1258 EEAPAMLDKPDIVYVVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQ 1317
Query: 1073 K-LYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELPPEIITRLQNQKVNKGNKATFE 1127
L I S D G +C R+ ++C+ + + E P + +++ +V G A F
Sbjct: 1318 YCLRICRVSRRDMGALTCTARNRHGTQTCSVTLELAEAP-RFESIMEDVEVGAGETARFA 1376
Query: 1128 IELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ + +G L + W+KD + S+H+ + + L + D G Y+C N
Sbjct: 1377 V-VVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQN 1432
Score = 47.2 bits (107), Expect = 6e-04
Identities = 61/278 (21%), Positives = 103/278 (37%), Gaps = 14/278 (5%)
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQ-FSNHIQLTIDGKKQKL 1163
PP L +Q V +G I + + +V W ++ ++ +G +L
Sbjct: 739 PPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRL 798
Query: 1164 KIYDCDLDDAGEYSC----EVGNSKCTAILTVEE--PSINFTLRLP-EFILVPANTDAYL 1216
+I + DAG Y+C E G +C A L V S + + P + + V A A
Sbjct: 799 RILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALF 858
Query: 1217 TVEIPDET-LDVTWYKKKSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK 1274
+ T ++V W + +++ K + D +K L++ EDD YTC L AK
Sbjct: 859 ECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAK 918
Query: 1275 STTKLKVEVVEFP---PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC 1331
+ P P + + G P P W +++
Sbjct: 919 DELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEES 978
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
++ + D SL I V + D G+Y + N G A
Sbjct: 979 ENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQA 1016
Score = 44.0 bits (99), Expect = 0.006
Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 1/108 (0%)
Query: 496 PVFEKPTSEEQSMAP-IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ 554
P + +S+ S AP F L + +G V +V+G P+P ++W R ++P Q
Sbjct: 725 PSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQ 784
Query: 555 DFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
+ + L I DAG +TC A N G L V A
Sbjct: 785 RRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRA 832
Score = 43.2 bits (97), Expect = 0.010
Identities = 35/150 (23%), Positives = 60/150 (40%), Gaps = 6/150 (4%)
Query: 1600 PPPEVIWYKNGNKLENDKEYNITT-KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEV 1658
P P + W K+ L ++ I + K+ ++ I + H+ Y A+N G+ +
Sbjct: 2482 PAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSC 2541
Query: 1659 TLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
T+ V P K P + + +++ + WKP D T Y +E+ + W V+
Sbjct: 2542 TVAVARVPGKLAPPEV-TQTYQDTALVLWKP--GDSRAPCT-YTLERRVDGESVWHPVSS 2597
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVG 1748
D Y + L FRV N G
Sbjct: 2598 GIPDC-YYNVTHLPVGVTVRFRVACANRAG 2626
Score = 42.7 bits (96), Expect = 0.014
Identities = 18/76 (23%), Positives = 40/76 (52%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ +I PPP+V W+K+G+ L ++ + + + + ++E + + + Y
Sbjct: 607 GADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMAT 666
Query: 1647 ASNTAGTSSVEVTLKV 1662
A+N G ++ +L V
Sbjct: 667 ATNELGQATCAASLTV 682
Score = 40.3 bits (90), Expect = 0.074
Identities = 46/226 (20%), Positives = 76/226 (33%), Gaps = 9/226 (3%)
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
Y V+ A + +V + +S V PL+++ E C+ G +V
Sbjct: 811 YTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPTDVEV 870
Query: 1514 TWYRDGKKLKTA----KATYENRX-XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
W G+ L+ A K ++ R Y C E+ S + ++
Sbjct: 871 DWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVR 930
Query: 1569 QK--PVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEK 1626
P+ T ED++ G I G PPP V W G +E + +
Sbjct: 931 PSLAPLFTRLLEDVEVLE--GRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGG 988
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+ I + Y + A NT G + L V + + GP
Sbjct: 989 LHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGP 1034
Score = 39.5 bits (88), Expect = 0.13
Identities = 26/84 (30%), Positives = 38/84 (45%), Gaps = 5/84 (5%)
Query: 1113 LQNQKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLD 1171
LQN V G + +T V W KDGS ++ + L +G++ L + +
Sbjct: 599 LQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAA 658
Query: 1172 DAGEYSC----EVGNSKCTAILTV 1191
DAG Y E+G + C A LTV
Sbjct: 659 DAGSYMATATNELGQATCAASLTV 682
Score = 39.1 bits (87), Expect = 0.17
Identities = 40/191 (20%), Positives = 71/191 (37%), Gaps = 13/191 (6%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
+FPP ++ + G TLL A P P+ W+ + KK ++PS+ S
Sbjct: 2452 DFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKD----KKSLRSEPSVIIVSCK 2507
Query: 1345 -----LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINI 1399
L+I + AG+Y+ N G V + P P + + + +
Sbjct: 2508 DGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVTQTYQDTALV 2567
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN-ITKTQTSIQNLKTNSSYRFRAYAVNE 1458
W ++ T Y +E + + W V + I ++ +L + RFR N
Sbjct: 2568 LWKPGDSRAPCT---YTLERRVDGESVWHPVSSGIPDCYYNVTHLPVGVTVRFRVACANR 2624
Query: 1459 VDISDASETTE 1469
S ++E
Sbjct: 2625 AGQGPFSNSSE 2635
Score = 38.3 bits (85), Expect = 0.30
Identities = 29/109 (26%), Positives = 45/109 (41%), Gaps = 5/109 (4%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F K K Q + EG L C A P P I+W+ + + + ++ + D
Sbjct: 2454 PPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGR--- 2510
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGE--ASLPIVLKIKTGEKEPPQVIE 739
+L I K G Y A N G +S + + G+ PP+V +
Sbjct: 2511 QLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVTQ 2559
Score = 37.5 bits (83), Expect = 0.52
Identities = 24/100 (24%), Positives = 35/100 (35%), Gaps = 1/100 (1%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
E P+F KL+ + +G C P P I+W + ++ + D
Sbjct: 2450 ESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDG 2509
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAG-FASSTTELIVEAP 603
L I AG + C A N G SS T + P
Sbjct: 2510 RQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVP 2549
Score = 37.1 bits (82), Expect = 0.69
Identities = 22/95 (23%), Positives = 36/95 (37%), Gaps = 5/95 (5%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY-----ENRXXXX 1536
P LK+ E L C+ P P ++W +D K L++ + + R
Sbjct: 2455 PVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLS 2514
Query: 1537 XXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
Y+C A N G + +SC V + + P
Sbjct: 2515 IPRAGKRHAGLYECSATNVLGSITSSCTVAVARVP 2549
Score = 36.3 bits (80), Expect = 1.2
Identities = 27/111 (24%), Positives = 46/111 (41%), Gaps = 4/111 (3%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPT---KSDGDTHSIT 790
PP LK ++ +GE+ L P P I+W K+ K +++ P+ S D +
Sbjct: 2454 PPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLL 2513
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE 841
+ + G+Y A N G +S + V + A PP +Q+
Sbjct: 2514 SIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLA-PPEVTQTYQD 2563
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/102 (24%), Positives = 44/102 (43%), Gaps = 3/102 (2%)
Query: 1566 GIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND-KEYNITTK 1624
G + P +S D Q + G + +++ ++G P P V W +N + D + + +
Sbjct: 735 GSKAPPTFKVSLMD--QSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAE 792
Query: 1625 EKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP 1666
+RI +R + YT +A N G E L+V P
Sbjct: 793 GGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHP 834
Score = 34.7 bits (76), Expect = 3.7
Identities = 32/180 (17%), Positives = 60/180 (33%), Gaps = 6/180 (3%)
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYK-KKSVIEDTEKFTLISDVKKRTLIIRKC--T 1259
P+ + V A +TV V W + +++E +S +R C +
Sbjct: 1267 PDIVYVVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVS 1326
Query: 1260 EDDQCEYTCVLLDAKSTTKLKV--EVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQP 1317
D TC + T V E+ E P+ + + G V + P P
Sbjct: 1327 RRDMGALTCTARNRHGTQTCSVTLELAE-APRFESIMEDVEVGAGETARFAVVVEGKPLP 1385
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
+ W + ++ + H + SL + D G+Y +N G + + +
Sbjct: 1386 DIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAV 1445
>BC047244-1|AAH47244.1| 858|Homo sapiens neural cell adhesion
molecule 1 protein.
Length = 858
Score = 102 bits (245), Expect = 1e-20
Identities = 141/690 (20%), Positives = 268/690 (38%), Gaps = 48/690 (6%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTI---D 1157
T V L +I+ V + ++ D + WF E N ++++ D
Sbjct: 16 TAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWND 75
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEV---GNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
L IY+ ++DDAG Y C V S+ A + V+ P DA
Sbjct: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
Query: 1215 YLTVEIPDETLDVTWYKKKS---VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC--- 1268
+ ++ +K K +++ +F ++S+ L IR + D+ Y C
Sbjct: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGR 192
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYER--EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
+L + K +V PP I + G VTL+ D + FP+P W + +
Sbjct: 193 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252
Query: 1327 IIKKCKHTKPSIDSKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
I++ + + I S +S LTIKKV+ D Y EN G D +++ + KP
Sbjct: 253 QIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY 312
Query: 1386 KPN--ILEIDSSSINICWDEPENTGNS-TIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
N +E++ C E +G+ I + + I + E S K +T +
Sbjct: 313 VENQTAMELEEQVTLTC----EASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGH 368
Query: 1443 LKTNSSYRFRAYAVNEVDISDASE--TTEYYKVIKET-----KIQ-SPTVEKPLKNITTE 1494
+ S R + + + +DA E T + +++ ++Q +P ++ P+ T E
Sbjct: 369 MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE 428
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT----YENRXXXXXXXX--XXXXXXXY 1548
N+ + +TC P ++W+RDG+ L ++ + Y Y
Sbjct: 429 GNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 487
Query: 1549 KCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGD-EWLVTAVIEGIP--PPEVI 1605
C A N G+ ++ +Q + S + ++ ++ G+P +
Sbjct: 488 NCTAVNRIGQESLEFIL-VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 546
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W G ++ + K Y+ ++ I LK + + A N G + + +
Sbjct: 547 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQ 606
Query: 1666 P--SKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRD 1722
P +P P + ++ + +I+ DDGG + Y + ++ ++ W +
Sbjct: 607 PVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV-RYRALSSEWKPEIRLPSG 665
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
+ ++ L+ N EY V+A+N G S+A
Sbjct: 666 SDHVMLKSLDWNAEYEVYVVAENQQGKSKA 695
Score = 95.9 bits (228), Expect = 1e-18
Identities = 120/536 (22%), Positives = 225/536 (41%), Gaps = 50/536 (9%)
Query: 993 DVGVIKCIVKDQE------TSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETAD 1046
D G+ KC+V ++ T + + ++ + + Q+F E V + +V ++S
Sbjct: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV-VSSLPPT 148
Query: 1047 VVWERDG-EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC----ILRDESCTAEVT 1101
++W+ G ++I K ++ +++ IR DEG Y C + R E ++
Sbjct: 149 IIWKHKGRDVILKKDVRFIVLSNNYLQ---IRGIKKTDEGTYRCEGRILARGEINFKDIQ 205
Query: 1102 V-VELPPEIITR--LQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEI-QFSNHIQLTI 1156
V V +PP I R + N N G T + + + W KDG +I Q + +
Sbjct: 206 VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF 265
Query: 1157 DGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTV-EEPSINFT-----LRLPEFI 1206
+L I D +D EY C + G T L V +P I + + L E +
Sbjct: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325
Query: 1207 LVP--ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLI------SDVKKRTLIIRKC 1258
+ A+ D ++ T +++ +K S ++ TL S + +L ++
Sbjct: 326 TLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSI 385
Query: 1259 TEDDQCEYTCVLLDA--KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQ 1316
D EY C + + + + +EV ++ PK+ Y + G+ V + + A+P
Sbjct: 386 QYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPVAVYTWE-GNQVNITCEVFAYPS 443
Query: 1317 PNDEWIVNSKIIKKCKHTKPSI-DSKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMN 1374
W + +++ ++ I ++ SAS L + D G Y N G +E
Sbjct: 444 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 503
Query: 1375 VTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEY----QEIDTTEWISV 1430
+ D PS P + E SS+ + +DEPE TG I+ Y E+ +E+ ++W
Sbjct: 504 LVQADTPSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA 562
Query: 1431 KNIT-KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVE 1485
K + + +I LK ++Y R A+N + + S +E+ + + +P +E
Sbjct: 563 KEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLE 618
Score = 85.8 bits (203), Expect = 2e-15
Identities = 93/405 (22%), Positives = 167/405 (41%), Gaps = 40/405 (9%)
Query: 593 SSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDIL 652
SS+T I A + D G V ++ F P Q EG D +
Sbjct: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
+ C +V+ P I W KG +++ +++ + S+ + L+I +KK EGTY
Sbjct: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-----NYLQIRGIKKTDEGTYRCEG 191
Query: 713 -VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKN 771
+ GE + + ++ Q + + + G+SV L G P PT++W K+
Sbjct: 192 RILARGEINFKDI-QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
Query: 772 NKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
+ ++ D+ +TI K K DE Y AEN G E A I + +
Sbjct: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDK-NDEAEYICIAENKAG--EQDATIHL----K 303
Query: 828 ENAEPPL-FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETIT------ 880
A+P + ++ + ++E+ + L + +P+PSITW + IS E +
Sbjct: 304 VFAKPKITYVENQTAMELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEK 361
Query: 881 -QNFDGENIELVITNVDS-------EIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ DG + V S D+G+Y C ASN+ G+ S + ++V+ ++
Sbjct: 362 QETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS--MYLEVQYAPKLQ 419
Query: 933 HLQKSYETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREI 975
Y T EG V + C+ + + W+ + + + ++ I
Sbjct: 420 GPVAVY-TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 463
Score = 80.2 bits (189), Expect = 7e-14
Identities = 132/662 (19%), Positives = 243/662 (36%), Gaps = 58/662 (8%)
Query: 1226 DVTWYKK--KSVIEDTEKFTLI-SDVKKRTLIIRKCTEDDQCEYTCVLL-DAKSTTKLKV 1281
D++W+ + + + ++ +++ +D TL I DD Y CV+ + S ++ V
Sbjct: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
Query: 1282 EVVEFPPKIV-DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V F + + + G D ++ D + P W + + K + + S
Sbjct: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
Query: 1341 KSASLTIKKVENTDAGIYK----LRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSS- 1395
+ L I+ ++ TD G Y+ + D+++ V + P+ + NI+ ++
Sbjct: 171 NNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV--PPTIQARQNIVNATANL 227
Query: 1396 --SINICWDE---PENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
S+ + D PE T + T +E QE D ++I + +Q +I+ + N
Sbjct: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIE-QEEDDEKYIFSDD--SSQLTIKKVDKNDEAE 284
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ A N+ DA+ + + K T +++ T E E + LTC G P
Sbjct: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTA--------MELEEQVTLTCEASGDPI 336
Query: 1511 PKVTWYRDGKKLKTA-KATYENRXXXXXX-------XXXXXXXXXYKCIAFNDHGEV--E 1560
P +TW + + + KA++ K I + D GE
Sbjct: 337 PSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICT 396
Query: 1561 TSCVVGIQQKPVITISNEDIKQKHKV------GDEWLVTAVIEGIPPPEVIWYKNGNKLE 1614
S +G + + K + V G++ +T + P + W+++G L
Sbjct: 397 ASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 456
Query: 1615 NDKEYNIT--TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP 1672
+ NI S + + + Y A N G S+E L D PS P
Sbjct: 457 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS-- 514
Query: 1673 VIMREISRESVTIEWKPPLDDGGLELTKYAIE----KHEPDNNRWIKVADVDRDVETYCI 1728
+ E + +++ P GG+ + KY E E +++W + + I
Sbjct: 515 IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME-GIVTI 573
Query: 1729 QKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITW 1788
L Y R+ A N G E + + PS D S+ +
Sbjct: 574 VGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVNL 632
Query: 1789 FPSEKNGGSPIIDYKVEIKQEGKKWK--XXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
+ +GGSPI Y V + +WK ++ L N Y+ + A N+ G
Sbjct: 633 IKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 691
Query: 1847 TS 1848
S
Sbjct: 692 KS 693
Score = 77.8 bits (183), Expect = 4e-13
Identities = 74/309 (23%), Positives = 127/309 (41%), Gaps = 35/309 (11%)
Query: 628 ILEGIPPTFSKKPKA--QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
++ +PPT + + G + L C PEP ++W GE+I +E+ I
Sbjct: 206 VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF 265
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
SD S L I V K E Y +A N+ GE I LK+ P++
Sbjct: 266 SDDS---SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA----KPKITYVENQTA 318
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKA-------LPTKSDG-DTHSIT------- 790
+ E V L+ + G+P P+ITW + + + + P K + D H +
Sbjct: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVS 378
Query: 791 --ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
LK + D G Y A N+ I + S + +E + P+ + + E
Sbjct: 379 SLTLKSIQYTDAGEYICTASNT--IGQDSQSMYLEVQYAPKLQGPVAVYTW------EGN 430
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCV 907
+ + V P +I+W+R+ +++ S + + ++ + + DSE D G+Y C
Sbjct: 431 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 490
Query: 908 ASNSAGKSS 916
A N G+ S
Sbjct: 491 AVNRIGQES 499
Score = 54.4 bits (125), Expect = 4e-06
Identities = 25/79 (31%), Positives = 41/79 (51%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G +V C EG+P P ++W + I+ +D + Y D+ + L I++V D + C
Sbjct: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N AG +T L V A
Sbjct: 288 IAENKAGEQDATIHLKVFA 306
Score = 48.0 bits (109), Expect = 4e-04
Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P A Y EG+ + + C + A P I+W F+ +++P N S I+ S L++T
Sbjct: 421 PVAVYTWEGNQVNITCEVFAYPSATISW-FRDGQLLPSSNYS-NIKIYNTPSASYLEVTP 478
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKS 743
+ G Y AVNR G+ SL +L ++ P + +EP S
Sbjct: 479 DSENDFGNYNCTAVNRIGQESLEFIL-VQADTPSSPSIDQVEPYSS 523
Score = 45.6 bits (103), Expect = 0.002
Identities = 44/189 (23%), Positives = 85/189 (44%), Gaps = 7/189 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSW-TKIVTVGGSVHE 1924
PS P V E S + +++ EPE+ GG PI Y E++ V + W +K + E
Sbjct: 510 PSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 568
Query: 1925 HCIENIKEKDEIIF--RISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNI 1982
+ + K E + R++A N G+ + + + + PS P ++ G++I
Sbjct: 569 GIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSI 628
Query: 1983 VMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+ + DGG+P+ Y + R ++ + W ++ + ++ L N Y + +
Sbjct: 629 KVNL--IKQDDGGSPIRHYLVRYRALS-SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 685
Query: 2043 ARNEIGLSE 2051
A N+ G S+
Sbjct: 686 AENQQGKSK 694
Score = 41.1 bits (92), Expect = 0.042
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 4/85 (4%)
Query: 520 HTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQ--MYYDDDNVATLVIREVFPED 577
+T +G+ V C+V YP I+WFR ++ PS ++ Y+ + + L + D
Sbjct: 425 YTWEGNQVNITCEVFAYPSATISWFRDGQLL-PSSNYSNIKIYNTPSASYLEVTPDSEND 483
Query: 578 AGTFTCVAKNAAGFASSTTELIVEA 602
G + C A N G S ++V+A
Sbjct: 484 FGNYNCTAVNRIG-QESLEFILVQA 507
Score = 40.7 bits (91), Expect = 0.056
Identities = 33/131 (25%), Positives = 53/131 (40%), Gaps = 3/131 (2%)
Query: 524 GSTVQFECQVEGYPRPQ-ITWFRQTAI-IKPSQD-FQMYYDDDNVATLVIREVFPEDAGT 580
G + F CQV G + + I+WF + P+Q + ++DD+ +TL I +DAG
Sbjct: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
Query: 581 FTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKP 640
+ CV G S T + + T D++ +PPT K
Sbjct: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Query: 641 KAQYVDEGSDI 651
K + V D+
Sbjct: 154 KGRDVILKKDV 164
>AJ314906-1|CAC85753.1| 1040|Homo sapiens obscurin protein.
Length = 1040
Score = 102 bits (245), Expect = 1e-20
Identities = 82/356 (23%), Positives = 145/356 (40%), Gaps = 39/356 (10%)
Query: 501 PTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYY 560
P+ AP+F+ +L+ + DG V F+C V G P P + WF+ +++ + +
Sbjct: 688 PSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINE 747
Query: 561 DDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXX 620
D L+I V P D G + C+A+N+ G +S+ EL V+ +D+ +
Sbjct: 748 DQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYF 807
Query: 621 XX---XXXADILEGIPPTFSKKPKAQYVDEGSDILL---------ECRLVAIPEPDIAWL 668
+ EG T + Q V+E D+ + + ++ P P + W
Sbjct: 808 SAQGYLSTSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWF 867
Query: 669 FKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
G+ + +I + + +H L+I +V + G Y N G A L ++
Sbjct: 868 KDGQPLTASAHIRMTDKKILH----TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVR 923
Query: 729 TGEKE-------------PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
++ PP+++E V++G S+ S +V G P PT+ W +
Sbjct: 924 GPDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAER 983
Query: 776 KAL---------PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
L S HS+ +L + + +G YT A N+ G A SA + V
Sbjct: 984 GVLWIGPDTPGYTVASSAQQHSLVLLDVGR-QHQGTYTCIASNAAGQALCSASLHV 1038
Score = 70.5 bits (165), Expect = 6e-11
Identities = 60/207 (28%), Positives = 95/207 (45%), Gaps = 22/207 (10%)
Query: 729 TGEKEPPQVIEPLKSMIVRQGESVI-LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDT- 786
T E + PQV+E L+ + V G + +V G P P + W K+ +P+ A D
Sbjct: 826 TDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKK 885
Query: 787 --HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV---EEPTEENAE-------PPL 834
H++ I+ + +D G Y N+ G A +SA + V +EP E+ A PP
Sbjct: 886 ILHTLEIISVTR-EDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPR 944
Query: 835 FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE-----IISP-SETITQNFDGENI 888
+ RF VK+ +I +V PVP++ W R I P + T +
Sbjct: 945 MLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQH 1004
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKS 915
LV+ +V + G Y C+ASN+AG++
Sbjct: 1005 SLVLLDVGRQ-HQGTYTCIASNAAGQA 1030
Score = 60.1 bits (139), Expect = 9e-08
Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 7/156 (4%)
Query: 1597 EGIPPPEVIWYKNGNKLE-NDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
E +P E WY NG ++ +D ++ +T + ++ + H+ + T + ++
Sbjct: 28 EAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASAR 87
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
+ V L + D P E V+ R S +VT+ W P+ DGG L Y +E E +W
Sbjct: 88 LTV-LGLPDPPEDAE--VVAR--SSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRL 142
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE 1751
++ E + L Y FRV A PVG E
Sbjct: 143 CHELVPGPEC-VVDGLAPGETYRFRVAAVGPVGAGE 177
Score = 54.4 bits (125), Expect = 4e-06
Identities = 30/119 (25%), Positives = 54/119 (45%), Gaps = 3/119 (2%)
Query: 815 ETSAVITVEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
ET A + EP + P+F+ Q V++ + VT P+PS+ W+++ +
Sbjct: 676 ETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGK 735
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
++ + N D + +I D G Y+C+A NS G SS A + +D+ +
Sbjct: 736 LLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDY 794
Score = 53.2 bits (122), Expect = 1e-05
Identities = 69/334 (20%), Positives = 125/334 (37%), Gaps = 24/334 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDN 564
+Q P+F G ++ EC V + W + + + + D
Sbjct: 464 KQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDG 523
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
+L+I + DAG +TC N G + + ++V GSE
Sbjct: 524 TCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVVVS------GSESEAESSSGGELDDA 577
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLEC-RLVAIPEPDIAW-LFKGEE---IVPDEN 679
+ F K A+ DE ++ L A PE W ++ +E + E
Sbjct: 578 FRRAARRLHRLFRTKSPAEVSDE--ELFLSADEGPAEPEEPADWQTYREDEHFICIRFEA 635
Query: 680 ISVA---IESDMHMYCSVLKITNVKKFQEGTYTV-VAVNREGEASL--PIVLKIKTGEKE 733
++ A + M+ ++ +K ++G V + +++E A + P L
Sbjct: 636 LTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDA 695
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA----LPTKSDGDTHSI 789
P + L++ V+ G V V G P P++ W K+ K ++ + + H +
Sbjct: 696 APVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 755
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
I+ D GVY AENS G++ T A + V+
Sbjct: 756 -IITAVVPADMGVYRCLAENSMGVSSTKAELRVD 788
Score = 50.0 bits (114), Expect = 9e-05
Identities = 39/192 (20%), Positives = 74/192 (38%), Gaps = 7/192 (3%)
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHT-KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD 1370
+A P W +N ++ + D +L ++ + AG + C A
Sbjct: 28 EAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAG----EVTFACRDAV 83
Query: 1371 VEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-IS 1429
+T+L P PP ++ S ++ + W P + G + Y VE +E T +W +
Sbjct: 84 ASARLTVLGLPDPPEDAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLC 143
Query: 1430 VKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
+ + + + L +YRFR AV V + + ++ + K P P +
Sbjct: 144 HELVPGPECVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-E 202
Query: 1490 NITTEPNEDIEL 1501
+ ED+ L
Sbjct: 203 SRQVAAGEDVSL 214
Score = 48.8 bits (111), Expect = 2e-04
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 6/118 (5%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHE 1924
P P + V +S +VTL W P S+GG + Y +E K W V G E
Sbjct: 94 PDPPEDAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGP--E 151
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRL-EKHATVPSPPTAPLEIRMVGS 1980
++ + + FR++A VG P Q+VRL E VP P+AP E R V +
Sbjct: 152 CVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQPSAP-ESRQVAA 208
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/90 (30%), Positives = 41/90 (45%)
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
PE V A D L +E+ E +V W+K I+ +F ++S +++ L+I+ T +D
Sbjct: 201 PESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAED 260
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVD 1292
Q EY C L V P VD
Sbjct: 261 QGEYHCGLAQGSICPAAATFQVALSPASVD 290
Score = 44.4 bits (100), Expect = 0.005
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 4/100 (4%)
Query: 1087 YSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK-ATFEIELTKGDALVR--WFKDG 1143
Y R++ T T P+++ L++ +V G + A F++++ KG R WFKDG
Sbjct: 812 YLSTSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKV-KGYPAPRLYWFKDG 870
Query: 1144 SEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
+ S HI++T L+I +D+G+Y+ + N+
Sbjct: 871 QPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNA 910
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 1031 KDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI 1090
+DV+ LE+E+ +E +V+W + E I+P +++ +G + L I+ + D+GEY C
Sbjct: 210 EDVS-LELEVVAEAGEVIWHKGMERIQP-GGRFEVVSQGRQQMLVIKGFTAEDQGEYHCG 267
Query: 1091 LRDES-CTAEVTV-VELPP 1107
L S C A T V L P
Sbjct: 268 LAQGSICPAAATFQVALSP 286
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 2/89 (2%)
Query: 1965 VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTL 2024
+P PP E+ S+ V SW P DGG L GY + +++ W ++ V
Sbjct: 93 LPDPPE-DAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHEL-VPGP 150
Query: 2025 KFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
+ + L+ TY R+ A +G EP+
Sbjct: 151 ECVVDGLAPGETYRFRVAAVGPVGAGEPV 179
Score = 42.7 bits (96), Expect = 0.014
Identities = 28/80 (35%), Positives = 40/80 (50%), Gaps = 4/80 (5%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGK-KQKL 1163
P +T LQNQ+V G +F+ +T G + VRWFKDG ++ +H + D + +L
Sbjct: 697 PVFLTELQNQEVQDGYPVSFDCVVT-GQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQL 755
Query: 1164 KIYDCDLDDAGEYSCEVGNS 1183
I D G Y C NS
Sbjct: 756 IITAVVPADMGVYRCLAENS 775
Score = 40.7 bits (91), Expect = 0.056
Identities = 23/81 (28%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT-- 1653
++G P P + W+K+G L +T K+ + I + R S +Y SN G
Sbjct: 856 VKGYPAPRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAY 915
Query: 1654 SSVEVTLKVYDKP-SKPEGPV 1673
SS + ++ D+P KP V
Sbjct: 916 SSARLLVRGPDEPEEKPASDV 936
Score = 39.9 bits (89), Expect = 0.098
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 1582 QKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS-VIRIKELKRS 1638
Q +V D + V+ V+ G P P V W+K+G LE D Y I ++ + I + +
Sbjct: 704 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 763
Query: 1639 HSSKYTIEASNTAGTSSVEVTLKV 1662
Y A N+ G SS + L+V
Sbjct: 764 DMGVYRCLAENSMGVSSTKAELRV 787
Score = 38.3 bits (85), Expect = 0.30
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1114 QNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDA 1173
++++V G + E+E+ V W K IQ ++ G++Q L I +D
Sbjct: 202 ESRQVAAGEDVSLELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQ 261
Query: 1174 GEYSCEVG-NSKCTAILTVE 1192
GEY C + S C A T +
Sbjct: 262 GEYHCGLAQGSICPAAATFQ 281
Score = 37.5 bits (83), Expect = 0.52
Identities = 27/116 (23%), Positives = 50/116 (43%), Gaps = 2/116 (1%)
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI-KLVARVTRNPVPSITWY 867
+++G TS E T + + P + +++ V + K +V P P + W+
Sbjct: 808 SAQGYLSTSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWF 867
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
++ + ++ S I L I +V E DSG Y SN+ G + AR+ +
Sbjct: 868 KDGQPLTASAHIRMTDKKILHTLEIISVTRE-DSGQYAAYISNAMGAAYSSARLLV 922
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 3/54 (5%)
Query: 1131 TKGDALVRWFKDGSEIQFS--NHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+K D RW KDG E+ +HI DG L I D DAG Y+C+V N
Sbjct: 494 SKADVRARWLKDGVELTDGRHHHIDQLGDG-TCSLLITGLDRADAGCYTCQVSN 546
Score = 34.7 bits (76), Expect = 3.7
Identities = 14/47 (29%), Positives = 22/47 (46%)
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
T +P L+N + + C+ G P P V W++DGK L+
Sbjct: 692 TSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLE 738
Score = 33.5 bits (73), Expect = 8.5
Identities = 21/92 (22%), Positives = 40/92 (43%), Gaps = 3/92 (3%)
Query: 1781 NESVYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKX-XXXXXXXXARIQKLSINTTYQFR 1838
+ +V ++W +GG + Y+VE+K+ +W+ + L+ TY+FR
Sbjct: 107 SHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFR 166
Query: 1839 IYARNEIGTSLPYTSDDKITIGKTLTP-PSQP 1869
+ A +G P + + + P P QP
Sbjct: 167 VAAVGPVGAGEPVHLPQTVRLAEPPKPVPPQP 198
>AJ314898-1|CAC85746.1| 646|Homo sapiens obscurin protein.
Length = 646
Score = 102 bits (244), Expect = 2e-20
Identities = 86/365 (23%), Positives = 149/365 (40%), Gaps = 24/365 (6%)
Query: 840 QEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEI 899
+E+ + +L+A ++ + ++TW ++ +SP L++ +V +
Sbjct: 294 REVLARLHEEAQLLAELS-DQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARD- 351
Query: 900 DSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY-----ETEEGKTVILECQTSH 954
D+G Y+CV S G R+ + + L K + G EC+TS
Sbjct: 352 DAGLYECV--------SRGGRIAYQLSVQGLARFLHKDMAGSCVDAVAGGPAQFECETSE 403
Query: 955 T-VSTKWYHNKKEISGMDHREIIQE-GRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVV 1012
V WY + E+ R + ++ G D G C V + L V
Sbjct: 404 AHVHVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRV 463
Query: 1013 KETIPEFIRKLQDFEVKEKDV---AILEVEINSETADVVWERDGEIIKPKKNKYDFEKRG 1069
E F ++ + +V A L E+ + +V W +DG+ + +K E G
Sbjct: 464 SEPKAVFAKEQPACREVQAEVGASATLSCEVAQDQMEVTWYKDGKKLS-SSSKVHVEAVG 522
Query: 1070 HIRKLYIRNTSVHDEGEYSCILRDE--SCTAEVTVVELPPEIITRLQNQKVNKGNKATFE 1127
+R+L ++ D GEYSC R + S + V E + R + Q G AT
Sbjct: 523 CMRRLVVQQVGQADSGEYSCEARGQRVSFRLDEPKVVFAKEQLARRKLQ-AEAGASATLS 581
Query: 1128 IELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
E+ + V W+KDG ++ S+ + + G ++L + DAGEYSCE G + +
Sbjct: 582 CEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSF 641
Query: 1188 ILTVE 1192
L V+
Sbjct: 642 HLDVK 646
Score = 93.1 bits (221), Expect = 1e-17
Identities = 129/649 (19%), Positives = 238/649 (36%), Gaps = 39/649 (6%)
Query: 638 KKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKI 697
K P+ V G D + C +A+P + WL EE+V ++++ E H L I
Sbjct: 5 KLPRKTAVRVG-DTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRH----TLTI 59
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV-IEPLKSMIVRQGESVILSA 756
+ G +A G+ + K P Q ++P+ R SVILS
Sbjct: 60 SQCCLEDVGQVAFMA----GDCQTSTQFCVSAPRKPPLQPPVDPVVK--ARMESSVILSW 113
Query: 757 QVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT-ILKPK----KVKDEGVYTLKAENSE 811
+ +T K L T + H + P+ V +EG + +
Sbjct: 114 SPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALN 173
Query: 812 GIAETSAVITVEEPTEENAEPPLFINR-FQEITVKEKGTIKLVARVTRNPVPSITWYRNN 870
++ + E P + P L + + + E G + +T + W+ +
Sbjct: 174 SFGQSPYL---EFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLT--VASAGEWFLDG 228
Query: 871 EIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN--SAGKSSHGARVTIDVEKV 928
+ + S + D L I V + + K VA+ S+ + A + K
Sbjct: 229 QALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKP 288
Query: 929 TFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ E ++ E + + W + + +S E+
Sbjct: 289 PAAAAREVLARLHEEAQLLAEL-SDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRD 347
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQD---FEVKEKDVAILEVEINSETA 1045
D G+ +C+ + + L V + + F+ K + A E E +
Sbjct: 348 VARDDAGLYECVSRGGRIAYQLSV-QGLARFLHKDMAGSCVDAVAGGPAQFECETSEAHV 406
Query: 1046 DVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVEL 1105
V W +DG + ++ E G +L + DEG YSC + ++S + V E
Sbjct: 407 HVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSE- 465
Query: 1106 PPEIITRLQ----NQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
P + + Q + G AT E+ + V W+KDG ++ S+ + + G +
Sbjct: 466 PKAVFAKEQPACREVQAEVGASATLSCEVAQDQMEVTWYKDGKKLSSSSKVHVEAVGCMR 525
Query: 1162 KLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR--LPEFILVPANTDAYLTVE 1219
+L + D+GEYSCE + + ++EP + F + A A L+ E
Sbjct: 526 RLVVQQVGQADSGEYSCEARGQRVS--FRLDEPKVVFAKEQLARRKLQAEAGASATLSCE 583
Query: 1220 IPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC 1268
+ +VTWYK + + K + + R L++++ + D EY+C
Sbjct: 584 VAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSC 632
Score = 57.6 bits (133), Expect = 5e-07
Identities = 45/187 (24%), Positives = 77/187 (41%), Gaps = 8/187 (4%)
Query: 1103 VELPPEIITRLQNQKVN--KGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKK 1160
V L P++ R + V +G + TF ++LT A WF DG ++ S+ ++ D +
Sbjct: 187 VHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASA-GEWFLDGQALKASSVYEIHCDRTR 245
Query: 1161 QKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEF-----ILVPANTDAY 1215
L I + G V N ++I + T P +L + +A
Sbjct: 246 HTLTIREVPASLHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQ 305
Query: 1216 LTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKS 1275
L E+ D+ VTW K + K+ + + +R L++R DD Y CV +
Sbjct: 306 LLAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRI 365
Query: 1276 TTKLKVE 1282
+L V+
Sbjct: 366 AYQLSVQ 372
Score = 33.5 bits (73), Expect = 8.5
Identities = 34/172 (19%), Positives = 64/172 (37%), Gaps = 4/172 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VGD + + +P V W +N ++ I+ + + I + +
Sbjct: 13 RVGDTAMFCVEL-AVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVA 71
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLD-DGGLELTKYAI 1703
A + ++ V+ P PV+ + SV + W PP + + + Y +
Sbjct: 72 FMAGDCQTSTQFCVSAPRKPPLQPPVDPVVKARME-SSVILSWSPPPHGERPVTIDGYLV 130
Query: 1704 EKHEPDNNRWIKVADVD-RDVETYCIQKLNENCEYMFRVIAQNPVGFSEALE 1754
EK + WI+ + + + + E + FRV A N G S LE
Sbjct: 131 EKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLE 182
>AK023854-1|BAB14704.1| 442|Homo sapiens .117). protein.
Length = 442
Score = 100 bits (240), Expect = 5e-20
Identities = 83/348 (23%), Positives = 138/348 (39%), Gaps = 10/348 (2%)
Query: 1039 EINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA 1098
E++ E A V W +DG ++ + E+ G +L + D GE+ C D+S
Sbjct: 3 ELSREDAPVRWYKDGLEVE-ESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFF 61
Query: 1099 EVTVVELPPEII---TRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLT 1155
VTV P I+ R + + E+ + VRW+KDG E++ S+ +QL
Sbjct: 62 TVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLG 121
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTL--RLPEFILVPANTD 1213
+G + L + +DAGEY CE + T + + EP + F P + V
Sbjct: 122 AEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEP 181
Query: 1214 AYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
L+ E+ V W +++ E L ++ +R L I+ YTC A
Sbjct: 182 VVLSCELSRAGAPVVWSHNGGPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAA 241
Query: 1274 KSTTKLKVEVVEFPP---KIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
L V P K+V + G D T + P + W+ N ++
Sbjct: 242 PGAPSLSFTVQVAEPLLVKLVSDLTPLTVHEGDDATFRCEVSP-PDADVTWLRNGAVVTP 300
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL 1378
+ + + S LT++ + DAG LR + A + + T L
Sbjct: 301 GPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETEL 348
Score = 97.1 bits (231), Expect = 6e-19
Identities = 98/442 (22%), Positives = 174/442 (39%), Gaps = 21/442 (4%)
Query: 853 VARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSA 912
+ ++R P + WY++ + SE + DG LV+ E D G++ C A
Sbjct: 1 MCELSREDAP-VRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPE-DGGEFVC----DA 54
Query: 913 GKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT--VILECQTSHTVS-TKWYHNKKEISG 969
G S VT+ V +S + G V L C+ + S +WY + E+
Sbjct: 55 GDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEA 114
Query: 970 MDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIR---KLQDF 1026
D ++ EG D G C + + + +++ E +F+
Sbjct: 115 SDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPL 174
Query: 1027 EVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGE 1086
V + +L E++ A VVW +G ++ + + G R L I+ G
Sbjct: 175 CVAPGEPVVLSCELSRAGAPVVWSHNGGPVQEGEG-LELHAEGPRRVLCIQAAGPAHAGL 233
Query: 1087 YSC----ILRDESCTAEVTVVE-LPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFK 1141
Y+C S + V V E L ++++ L V++G+ ATF E++ DA V W +
Sbjct: 234 YTCQSGAAPGAPSLSFTVQVAEPLLVKLVSDLTPLTVHEGDDATFRCEVSPPDADVTWLR 293
Query: 1142 DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLR 1201
+G+ + +++ +G + L + C L DAG + G++ +A L V E + F R
Sbjct: 294 NGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRR 353
Query: 1202 LPEFILVPANTDAYLTVEI--PDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
L + + D L +E V W + + + ++ D L I
Sbjct: 354 LQD-VRAEEGQDVCLEMETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVI 412
Query: 1260 EDDQCEYTCVLLDAKSTTKLKV 1281
DQ Y C ++ +L V
Sbjct: 413 LADQGTYGCESHHDRTLARLSV 434
Score = 76.6 bits (180), Expect = 9e-13
Identities = 82/369 (22%), Positives = 135/369 (36%), Gaps = 14/369 (3%)
Query: 950 CQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE--- 1005
C+ S +WY + E+ + + ++G D G C D
Sbjct: 2 CELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFF 61
Query: 1006 TSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDF 1065
T T+ E I + D L E+ + V W +DG ++ +
Sbjct: 62 TVTVTAPPERIVHPAARSLDLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEAS-DALQL 120
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEII---TRLQNQKVNKGN 1122
G R L + + D GEY C R E+ T V + E P + + T V G
Sbjct: 121 GAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGE 180
Query: 1123 KATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
EL++ A V W +G +Q ++L +G ++ L I AG Y+C+ G
Sbjct: 181 PVVLSCELSRAGAPVVWSHNGGPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGA 240
Query: 1183 SKCTAILT----VEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIED 1238
+ L+ V EP + + + V DA E+ DVTW + +V+
Sbjct: 241 APGAPSLSFTVQVAEPLLVKLVSDLTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTP 300
Query: 1239 TEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYR 1298
+ + + R L +R C D T L + T ++ V E + ++ R
Sbjct: 301 GPQVEMAQNGSSRILTLRGCQLGD--AGTVTLRAGSTATSARLHVRETELLFLRRLQDVR 358
Query: 1299 IKRGSDVTL 1307
+ G DV L
Sbjct: 359 AEEGQDVCL 367
>AY090737-1|AAM00025.1| 1026|Homo sapiens contactin 4 protein.
Length = 1026
Score = 100 bits (239), Expect = 7e-20
Identities = 192/916 (20%), Positives = 335/916 (36%), Gaps = 80/916 (8%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD-LDDAGEYSCEVGNSKCTAILTVEEPS 1195
+RW +G+++ + ++ + L I + + DAG Y C NS T + +
Sbjct: 60 IRWKLNGTDVDTGMDFRYSV--VEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQ 117
Query: 1196 I----NFTLRLPEFILVPANTDAYLTVEIPDET--LDVTW-YKKKSVIEDTEKFTLISDV 1248
NF R + V L P + L W + + +D +F
Sbjct: 118 FAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFV---SQ 174
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLDAKSTTK---------LKVEVV--EFPPKI-VDYERE 1296
+ L I K + D YTCV+ + + K L+ + V E+ PKI V +
Sbjct: 175 ETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPET 234
Query: 1297 YRIKRGSDVTLLVDYQAFPQPNDEW--IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
+G+ V L P P W I +K + K + L I + D
Sbjct: 235 VPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK-----SNGILEIPNFQQED 289
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
AG+Y+ EN+ G +T +P+ K N + + N+ W+ N
Sbjct: 290 AGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEE-NVFWECKANGRPKPTYK 348
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI 1474
++ + + T + I ++ T T I NL Y+ A + V S+A VI
Sbjct: 349 WLKNGEPLLTRDRIQIEQGTLNIT-IVNLSDAGMYQCLAENKHGVIFSNAE-----LSVI 402
Query: 1475 KETKIQSPTVEKPLKNIT-TEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR 1532
S T+ LK +T + ++ + C P+P TW + LK + T
Sbjct: 403 AVGPDFSRTL---LKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISED 459
Query: 1533 XXXXXXXXXXXXXXXYKCIAFNDHGEVETS--CVVGIQQKPVITISNEDIKQKHKVGDEW 1590
Y CIA N G ++ VV + ++ S+ D+ VG+
Sbjct: 460 GNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT----VGESI 515
Query: 1591 LVTAVIEGIPPPEVI--WYKNGNKLENDKEYN----ITTKEKTSVIRIKELKRSHSSKYT 1644
++ + +++ W NG+ ++ D++ + + ++ + I+ ++ H+ KY
Sbjct: 516 VLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYV 575
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+ S L V P PE V + EI+ + + W+P D+ +T Y I+
Sbjct: 576 CMVQTSVDRLSAAADLIVRGPPGPPEA-VTIDEITDTTAQLSWRPGPDNHS-PITMYVIQ 633
Query: 1705 KHEPDNNRWIKVADVDRDVE----TYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIV 1759
P + W V+ V ++ T + LN EY FR +A N +G E + SE
Sbjct: 634 ARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRR 693
Query: 1760 IKTALDVPSXXXXXXXXXXIDNESVYITW--FPSEKNGGSPIIDYKVEIKQEGKK-WKXX 1816
+ AL P + ITW P E G Y V + GK W
Sbjct: 694 TEEAL--PEVTPANVSGGGGSKSELVITWETVPEELQNGRG-FGYVVAFRPYGKMIWMLT 750
Query: 1817 XXXXXXXAR--IQKLSIN--TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNF 1872
+R + S++ + ++ ++ N G P+ S + P P +
Sbjct: 751 VLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PF-SPTTVVYSAEEEPTKPPASI 808
Query: 1873 VVSESTSRSVTLKWTEPESNGGSPITNYIIEF--KTVKGKSWTKIVTVGGSVHEHCIENI 1930
++ + + W P I Y +++ K ++ KI TVG I N+
Sbjct: 809 FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTK-ITNL 867
Query: 1931 KEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP 1990
K + A N+ G S +V + PS P + S I++
Sbjct: 868 KGSVLYHLAVKAYNSAGTG--PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVK 925
Query: 1991 EWDGGAPLLGYNIAIR 2006
D + + GY + R
Sbjct: 926 ALDNESEVKGYKVLYR 941
Score = 99.1 bits (236), Expect = 2e-19
Identities = 197/907 (21%), Positives = 340/907 (37%), Gaps = 92/907 (10%)
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
E+ +KL V NP P I W N + + L+I N + D+G Y+
Sbjct: 42 EEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDF--RYSVVEGSLLINNPNKTQDAGTYQ 99
Query: 906 CVASNSAGKS-SHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWY 961
C A+NS G S A++ F + + G+ ++L C S +S W
Sbjct: 100 CTATNSFGTIVSREAKLQFAYLD-NFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWI 158
Query: 962 HNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETS-------TMLVVKE 1014
N+ S D+R + + DVG C+V + T+ T L+++
Sbjct: 159 FNEYP-SYQDNRRFVSQ-ETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRN 216
Query: 1015 --TIPEFIRKLQ-DFE--VKEKDVAILEVE---INSETADVVWER-DGEIIKPKKNKYDF 1065
+ E+ K++ F V A +++E + + ++W R DG+ I K ++
Sbjct: 217 DGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRH-- 274
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCIL---RDESCTAEVTVVELPPEIITRLQNQKVNKGN 1122
K I L I N D G Y C+ R ++ P I ++ + V
Sbjct: 275 -KSNGI--LEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEE 331
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG 1181
+E + + +W K+G + + IQ+ ++ L I +L DAG Y C
Sbjct: 332 NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI----EQGTLNITIVNLSDAGMYQCLAE 387
Query: 1182 NSKCTAILTVE------EPSINFTLRLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKS 1234
N E P + TL L LV + + + V TW K +
Sbjct: 388 NKHGVIFSNAELSVIAVGPDFSRTL-LKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRD 446
Query: 1235 VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE-VVEFPPKIVDY 1293
++++ E+ T+ D R + + T+ D YTC+ + T VV+ P +++
Sbjct: 447 ILKENERITISEDGNLRIINV---TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVP 503
Query: 1294 EREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKII---KKCKHTKPSIDSKSAS-LTI 1347
+ G + L V + W N +I + H + SA L I
Sbjct: 504 PSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMI 563
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENT 1407
+ ++ AG Y ++ + ++ + P PP I EI ++ + W P
Sbjct: 564 RNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSW-RPGPD 622
Query: 1408 GNSTIIYYVVEYQEIDTTEWISVKNIT-----KTQT-SIQNLKTNSSYRFRAYAVNEVDI 1461
+S I YV++ + + W +V + KT T ++ L Y FR A N + I
Sbjct: 623 NHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGI 682
Query: 1462 SDAS------ETTEYYKVIKETKIQSPTVEKPLKNITTEP-NEDIELTCIFGGV----PQ 1510
+ S T E + + K IT E E+++ FG V P
Sbjct: 683 GEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPY 742
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE---VETSCVVGI 1567
K+ W L + +R K FN+ GE T+ V
Sbjct: 743 GKMIW-----MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 797
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIE----GIPPPEVIWYKNGNKLENDKEYNITT 1623
+++P ++ + E + +E I EV ++++ +K EN ++ T
Sbjct: 798 EEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIR-TV 856
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISR 1680
+TS +I LK S ++A N+AGT T+ V + PS+P G +I S
Sbjct: 857 GNQTST-KITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNS-SD 914
Query: 1681 ESVTIEW 1687
+ + W
Sbjct: 915 SKIILNW 921
Score = 99.1 bits (236), Expect = 2e-19
Identities = 84/317 (26%), Positives = 145/317 (45%), Gaps = 27/317 (8%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P+ +G+ + LEC + P P I W + + P +A ++ H +L+I N
Sbjct: 232 PETVPTAKGATVKLECFALGNPVPTIIW--RRADGKP-----IARKARRHKSNGILEIPN 284
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVV 759
++ G Y VA N G+ V + + P I+ + + V E+V +
Sbjct: 285 FQQEDAGLYECVAENSRGKN----VARGQLTFYAQPNWIQKINDIHVAMEENVFWECKAN 340
Query: 760 GNPRPTITWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
G P+PT W KN +P+ + + T +ITI+ + D G+Y AEN G+ ++A
Sbjct: 341 GRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIV---NLSDAGMYQCLAENKHGVIFSNA 397
Query: 819 VITVEEPTEENAEPPLFINRFQEIT-VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
++V P + +T VK G + + + +P P TW + +I+ +E
Sbjct: 398 ELSVIA-----VGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENE 452
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS 937
IT + DG L I NV ++ D+G Y C+A+N G +S + V+ T V S
Sbjct: 453 RITISEDG---NLRIINV-TKSDAGSYTCIATNHFGTASSTGNLV--VKDPTRVMVPPSS 506
Query: 938 YETEEGKTVILECQTSH 954
+ G++++L CQ +H
Sbjct: 507 MDVTVGESIVLPCQVTH 523
Score = 84.2 bits (199), Expect = 5e-15
Identities = 144/618 (23%), Positives = 234/618 (37%), Gaps = 66/618 (10%)
Query: 510 PIFVEKLRPKHTP---DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
PIF+++ P P + V+ C+V+G P+P I W + DF+ Y +
Sbjct: 26 PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFR--YSVVEGS 83
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
L+ +DAGT+ C A N+ G S + A L + T
Sbjct: 84 LLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNF---KTRTRSTVSVRRGQGM 140
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
+L G PP + A +E R V+ E ++ K E +S
Sbjct: 141 VLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVS-QETGNLYIAKVE------------KS 187
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
D+ Y V+ T G T + + +G KI E + P+ + K V
Sbjct: 188 DVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMG-EYEPKI---EVQFPETVPTAKGATV 243
Query: 747 RQGESVILSAQVVGNPRPTITWCK-NNKPV--KALPTKSDGDTHSITILKPKKVKDEGVY 803
+ L +GNP PTI W + + KP+ KA KS+G I + + +D G+Y
Sbjct: 244 K------LECFALGNPVPTIIWRRADGKPIARKARRHKSNG----ILEIPNFQQEDAGLY 293
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
AENS G +T P +I + +I V + + + P P+
Sbjct: 294 ECVAENSRGKNVARGQLTF-------YAQPNWIQKINDIHVAMEENVFWECKANGRPKPT 346
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W +N E + + I + + + I N+ D+G Y+C+A N G A +++
Sbjct: 347 YKWLKNGEPLLTRDRI--QIEQGTLNITIVNLS---DAGMYQCLAENKHGVIFSNAELSV 401
Query: 924 DVEKVTFVKHLQKSYE-TEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXX 982
F + L K + G V++EC+ + Y KK + E I
Sbjct: 402 IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV-YTWKKGRDILKENERITISEDG 460
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPEFI-RKLQDFEVKEKDVAILE 1037
D G CI + ++ LVVK+ + D V E V +
Sbjct: 461 NLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQ 520
Query: 1038 VEINSETADVV--WERDGEIIKPKKNKYDFEKRG---HIRKLYIRNTSVHDEGEYSCILR 1092
V + + D+V W +G +I ++ FE+ G L IRN + G+Y C+++
Sbjct: 521 V-THDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQ 579
Query: 1093 ---DESCTAEVTVVELPP 1107
D A +V PP
Sbjct: 580 TSVDRLSAAADLIVRGPP 597
Score = 82.6 bits (195), Expect = 1e-14
Identities = 131/565 (23%), Positives = 228/565 (40%), Gaps = 53/565 (9%)
Query: 647 EGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE- 705
E + L C + P+P I W G ++ + ++ L I N K Q+
Sbjct: 42 EEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVE------GSLLINNPNKTQDA 95
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES-VILSAQVVGNPRP 764
GTY A N G + K++ + + ++ VR+G+ V+L +
Sbjct: 96 GTYQCTATNSFG-TIVSREAKLQFAYLDNFKT-RTRSTVSVRRGQGMVLLCGPPPHSGEL 153
Query: 765 TITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYTLKAENS----EGIAETSAV 819
+ W N P + +T ++ I K +K D G YT N+ + + + +
Sbjct: 154 SYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEK-SDVGNYTCVVTNTVTNHKVLGPPTPL 212
Query: 820 ITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWYRNNEIISPSET 878
I + EP + + +F E KG T+KL NPVP+I W R + P
Sbjct: 213 ILRNDGVMGEYEPKIEV-QFPETVPTAKGATVKLECFALGNPVPTIIWRRADG--KPIAR 269
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
+ I L I N E D+G Y+CVA NS GK+ ++T + +++ + +
Sbjct: 270 KARRHKSNGI-LEIPNFQQE-DAGLYECVAENSRGKNVARGQLTFYAQP-NWIQKINDIH 326
Query: 939 ETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
E + V EC+ + + KW N + + D +I Q D G+
Sbjct: 327 VAME-ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ----GTLNITIVNLSDAGM 381
Query: 997 IKCIVKDQE----TSTMLVVKETIPEFIRKL--QDFEVKEKDVAILEVEINSETADV-VW 1049
+C+ +++ ++ L V P+F R L + VK ++E + + V W
Sbjct: 382 YQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW 441
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELP 1106
++ +I+K + + + G++R I N + D G Y+CI + TA T VV+ P
Sbjct: 442 KKGRDILK-ENERITISEDGNLR---IINVTKSDAGSYTCIATNHFGTASSTGNLVVKDP 497
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKG---DALVRWFKDGSEIQF---SNHIQLTIDGKK 1160
++ + V G ++T D + W +G I F +H + + G+
Sbjct: 498 TRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFE-RVGGQD 556
Query: 1161 Q--KLKIYDCDLDDAGEYSCEVGNS 1183
L I + L AG+Y C V S
Sbjct: 557 SAGDLMIRNIQLKHAGKYVCMVQTS 581
Score = 65.3 bits (152), Expect = 2e-09
Identities = 135/596 (22%), Positives = 230/596 (38%), Gaps = 67/596 (11%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSIT 790
+EP V+ PL S + + V L+ +V GNP+P I W N V + + S+
Sbjct: 30 QEPSPVMFPLDS----EEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLL 85
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE-ITVKE-KG 848
I P K +D G Y A NS G I E + A F R + ++V+ +G
Sbjct: 86 INNPNKTQDAGTYQCTATNSFG------TIVSREAKLQFAYLDNFKTRTRSTVSVRRGQG 139
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNF-DGENIELVITNVDSEIDSGDYKCV 907
+ L + S W N PS + F E L I V+ D G+Y CV
Sbjct: 140 MVLLCGPPPHSGELSYAWIFNE---YPSYQDNRRFVSQETGNLYIAKVEKS-DVGNYTCV 195
Query: 908 ASNS-AGKSSHGARVTIDVEKVTFVKHLQKSYE--------TEEGKTVILEC-QTSHTVS 957
+N+ G + + + + E T +G TV LEC + V
Sbjct: 196 VTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVP 255
Query: 958 T-KWYH-NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKET 1015
T W + K I+ R+ + D G+ +C+ ++ + + T
Sbjct: 256 TIIWRRADGKPIA----RKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLT 311
Query: 1016 I---PEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHI 1071
P +I+K+ D V ++ E + N W ++GE + +++ E+
Sbjct: 312 FYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLL-TRDRIQIEQ---- 366
Query: 1072 RKLYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQ--KVNKGNKAT 1125
L I ++ D G Y C+ ++ AE++V+ + P+ L + V G +
Sbjct: 367 GTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVV 426
Query: 1126 FEIELTKGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EV 1180
E + V +K G +I N I ++ DG L+I + DAG Y+C
Sbjct: 427 IECKPKASPKPVYTWKKGRDILKENERITISEDG---NLRIINVTKSDAGSYTCIATNHF 483
Query: 1181 GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP-DETLDV--TWYKKKSVIE 1237
G + T L V++P+ + P + V L ++ D +LD+ TW +I+
Sbjct: 484 GTASSTGNLVVKDPT--RVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLID 541
Query: 1238 ---DTEKFTLISDVKKR-TLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE-VVEFPP 1288
D + F + L+IR +Y C++ + + +V PP
Sbjct: 542 FDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 597
Score = 57.2 bits (132), Expect = 6e-07
Identities = 47/173 (27%), Positives = 68/173 (39%), Gaps = 14/173 (8%)
Query: 1852 TSDDKITIGKTLT---PPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVK 1908
TS D+++ L PP P + E T + L W P + SPIT Y+I+ +T
Sbjct: 580 TSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSW-RPGPDNHSPITMYVIQARTPF 638
Query: 1909 GKSWTKIVTV----GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHAT 1964
W + TV G + + E FR A N +G+ P+ R + A
Sbjct: 639 SVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEAL 698
Query: 1965 VPSPPTAPLEIRMVG---SNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
P P + G S +V+T PE GY +A R K +WM
Sbjct: 699 ---PEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 748
>AF549455-1|AAP05786.1| 1026|Homo sapiens BIG-2 protein.
Length = 1026
Score = 100 bits (239), Expect = 7e-20
Identities = 192/916 (20%), Positives = 335/916 (36%), Gaps = 80/916 (8%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCD-LDDAGEYSCEVGNSKCTAILTVEEPS 1195
+RW +G+++ + ++ + L I + + DAG Y C NS T + +
Sbjct: 60 IRWKLNGTDVDTGMDFRYSV--VEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQ 117
Query: 1196 I----NFTLRLPEFILVPANTDAYLTVEIPDET--LDVTW-YKKKSVIEDTEKFTLISDV 1248
NF R + V L P + L W + + +D +F
Sbjct: 118 FAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFV---SQ 174
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLDAKSTTK---------LKVEVV--EFPPKI-VDYERE 1296
+ L I K + D YTCV+ + + K L+ + V E+ PKI V +
Sbjct: 175 ETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPET 234
Query: 1297 YRIKRGSDVTLLVDYQAFPQPNDEW--IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
+G+ V L P P W I +K + K + L I + D
Sbjct: 235 VPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK-----SNGILEIPNFQQED 289
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
AG+Y+ EN+ G +T +P+ K N + + N+ W+ N
Sbjct: 290 AGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEE-NVFWECKANGRPKPTYK 348
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI 1474
++ + + T + I ++ T T I NL Y+ A + V S+A VI
Sbjct: 349 WLKNGEPLLTRDRIQIEQGTLNIT-IVNLSDAGMYQCLAENKHGVIFSNAE-----LSVI 402
Query: 1475 KETKIQSPTVEKPLKNIT-TEPNEDIELTCIFGGVPQPKVTWYRDGKKLK-TAKATYENR 1532
S T+ LK +T + ++ + C P+P TW + LK + T
Sbjct: 403 AVGPDFSRTL---LKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISED 459
Query: 1533 XXXXXXXXXXXXXXXYKCIAFNDHGEVETS--CVVGIQQKPVITISNEDIKQKHKVGDEW 1590
Y CIA N G ++ VV + ++ S+ D+ VG+
Sbjct: 460 GNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT----VGESI 515
Query: 1591 LVTAVIEGIPPPEVI--WYKNGNKLENDKEYN----ITTKEKTSVIRIKELKRSHSSKYT 1644
++ + +++ W NG+ ++ D++ + + ++ + I+ ++ H+ KY
Sbjct: 516 VLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYV 575
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+ S L V P PE V + EI+ + + W+P D+ +T Y I+
Sbjct: 576 CMVQTSVDRLSAAADLIVRGPPGPPEA-VTIDEITDTTAQLSWRPGPDNHS-PITMYVIQ 633
Query: 1705 KHEPDNNRWIKVADVDRDVE----TYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIV 1759
P + W V+ V ++ T + LN EY FR +A N +G E + SE
Sbjct: 634 ARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRR 693
Query: 1760 IKTALDVPSXXXXXXXXXXIDNESVYITW--FPSEKNGGSPIIDYKVEIKQEGKK-WKXX 1816
+ AL P + ITW P E G Y V + GK W
Sbjct: 694 TEEAL--PEVTPANVSGGGGSKSELVITWETVPEELQNGRG-FGYVVAFRPYGKMIWMLT 750
Query: 1817 XXXXXXXAR--IQKLSIN--TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNF 1872
+R + S++ + ++ ++ N G P+ S + P P +
Sbjct: 751 VLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PF-SPTTVVYSAEEEPTKPPASI 808
Query: 1873 VVSESTSRSVTLKWTEPESNGGSPITNYIIEF--KTVKGKSWTKIVTVGGSVHEHCIENI 1930
++ + + W P I Y +++ K ++ KI TVG I N+
Sbjct: 809 FARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTK-ITNL 867
Query: 1931 KEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP 1990
K + A N+ G S +V + PS P + S I++
Sbjct: 868 KGSVLYHLAVKAYNSAGTG--PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVK 925
Query: 1991 EWDGGAPLLGYNIAIR 2006
D + + GY + R
Sbjct: 926 ALDNESEVKGYKVLYR 941
Score = 99.1 bits (236), Expect = 2e-19
Identities = 197/907 (21%), Positives = 340/907 (37%), Gaps = 92/907 (10%)
Query: 846 EKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
E+ +KL V NP P I W N + + L+I N + D+G Y+
Sbjct: 42 EEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDF--RYSVVEGSLLINNPNKTQDAGTYQ 99
Query: 906 CVASNSAGKS-SHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT---SHTVSTKWY 961
C A+NS G S A++ F + + G+ ++L C S +S W
Sbjct: 100 CTATNSFGTIVSREAKLQFAYLD-NFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWI 158
Query: 962 HNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETS-------TMLVVKE 1014
N+ S D+R + + DVG C+V + T+ T L+++
Sbjct: 159 FNEYP-SYQDNRRFVSQ-ETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRN 216
Query: 1015 --TIPEFIRKLQ-DFE--VKEKDVAILEVE---INSETADVVWER-DGEIIKPKKNKYDF 1065
+ E+ K++ F V A +++E + + ++W R DG+ I K ++
Sbjct: 217 DGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRH-- 274
Query: 1066 EKRGHIRKLYIRNTSVHDEGEYSCIL---RDESCTAEVTVVELPPEIITRLQNQKVNKGN 1122
K I L I N D G Y C+ R ++ P I ++ + V
Sbjct: 275 -KSNGI--LEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEE 331
Query: 1123 KATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG 1181
+E + + +W K+G + + IQ+ ++ L I +L DAG Y C
Sbjct: 332 NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI----EQGTLNITIVNLSDAGMYQCLAE 387
Query: 1182 NSKCTAILTVE------EPSINFTLRLPEFILVPANTDAYLTVEIPDETLDV-TWYKKKS 1234
N E P + TL L LV + + + V TW K +
Sbjct: 388 NKHGVIFSNAELSVIAVGPDFSRTL-LKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRD 446
Query: 1235 VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE-VVEFPPKIVDY 1293
++++ E+ T+ D R + + T+ D YTC+ + T VV+ P +++
Sbjct: 447 ILKENERITISEDGNLRIINV---TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVP 503
Query: 1294 EREYRIKRGSDVTL--LVDYQAFPQPNDEWIVNSKII---KKCKHTKPSIDSKSAS-LTI 1347
+ G + L V + W N +I + H + SA L I
Sbjct: 504 PSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMI 563
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENT 1407
+ ++ AG Y ++ + ++ + P PP I EI ++ + W P
Sbjct: 564 RNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSW-RPGPD 622
Query: 1408 GNSTIIYYVVEYQEIDTTEWISVKNIT-----KTQT-SIQNLKTNSSYRFRAYAVNEVDI 1461
+S I YV++ + + W +V + KT T ++ L Y FR A N + I
Sbjct: 623 NHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGI 682
Query: 1462 SDAS------ETTEYYKVIKETKIQSPTVEKPLKNITTEP-NEDIELTCIFGGV----PQ 1510
+ S T E + + K IT E E+++ FG V P
Sbjct: 683 GEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPY 742
Query: 1511 PKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE---VETSCVVGI 1567
K+ W L + +R K FN+ GE T+ V
Sbjct: 743 GKMIW-----MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 797
Query: 1568 QQKPVITISNEDIKQKHKVGDEWLVTAVIE----GIPPPEVIWYKNGNKLENDKEYNITT 1623
+++P ++ + E + +E I EV ++++ +K EN ++ T
Sbjct: 798 EEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIR-TV 856
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISR 1680
+TS +I LK S ++A N+AGT T+ V + PS+P G +I S
Sbjct: 857 GNQTST-KITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNS-SD 914
Query: 1681 ESVTIEW 1687
+ + W
Sbjct: 915 SKIILNW 921
Score = 99.1 bits (236), Expect = 2e-19
Identities = 84/317 (26%), Positives = 145/317 (45%), Gaps = 27/317 (8%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P+ +G+ + LEC + P P I W + + P +A ++ H +L+I N
Sbjct: 232 PETVPTAKGATVKLECFALGNPVPTIIW--RRADGKP-----IARKARRHKSNGILEIPN 284
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVV 759
++ G Y VA N G+ V + + P I+ + + V E+V +
Sbjct: 285 FQQEDAGLYECVAENSRGKN----VARGQLTFYAQPNWIQKINDIHVAMEENVFWECKAN 340
Query: 760 GNPRPTITWCKNNKPVKALP-TKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
G P+PT W KN +P+ + + T +ITI+ + D G+Y AEN G+ ++A
Sbjct: 341 GRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIV---NLSDAGMYQCLAENKHGVIFSNA 397
Query: 819 VITVEEPTEENAEPPLFINRFQEIT-VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
++V P + +T VK G + + + +P P TW + +I+ +E
Sbjct: 398 ELSVIA-----VGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENE 452
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS 937
IT + DG L I NV ++ D+G Y C+A+N G +S + V+ T V S
Sbjct: 453 RITISEDG---NLRIINV-TKSDAGSYTCIATNHFGTASSTGNLV--VKDPTRVMVPPSS 506
Query: 938 YETEEGKTVILECQTSH 954
+ G++++L CQ +H
Sbjct: 507 MDVTVGESIVLPCQVTH 523
Score = 84.2 bits (199), Expect = 5e-15
Identities = 144/618 (23%), Positives = 234/618 (37%), Gaps = 66/618 (10%)
Query: 510 PIFVEKLRPKHTP---DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
PIF+++ P P + V+ C+V+G P+P I W + DF+ Y +
Sbjct: 26 PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFR--YSVVEGS 83
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
L+ +DAGT+ C A N+ G S + A L + T
Sbjct: 84 LLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNF---KTRTRSTVSVRRGQGM 140
Query: 627 DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIES 686
+L G PP + A +E R V+ E ++ K E +S
Sbjct: 141 VLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVS-QETGNLYIAKVE------------KS 187
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
D+ Y V+ T G T + + +G KI E + P+ + K V
Sbjct: 188 DVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMG-EYEPKI---EVQFPETVPTAKGATV 243
Query: 747 RQGESVILSAQVVGNPRPTITWCK-NNKPV--KALPTKSDGDTHSITILKPKKVKDEGVY 803
+ L +GNP PTI W + + KP+ KA KS+G I + + +D G+Y
Sbjct: 244 K------LECFALGNPVPTIIWRRADGKPIARKARRHKSNG----ILEIPNFQQEDAGLY 293
Query: 804 TLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
AENS G +T P +I + +I V + + + P P+
Sbjct: 294 ECVAENSRGKNVARGQLTF-------YAQPNWIQKINDIHVAMEENVFWECKANGRPKPT 346
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W +N E + + I + + + I N+ D+G Y+C+A N G A +++
Sbjct: 347 YKWLKNGEPLLTRDRI--QIEQGTLNITIVNLS---DAGMYQCLAENKHGVIFSNAELSV 401
Query: 924 DVEKVTFVKHLQKSYE-TEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXX 982
F + L K + G V++EC+ + Y KK + E I
Sbjct: 402 IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV-YTWKKGRDILKENERITISEDG 460
Query: 983 XXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPEFI-RKLQDFEVKEKDVAILE 1037
D G CI + ++ LVVK+ + D V E V +
Sbjct: 461 NLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQ 520
Query: 1038 VEINSETADVV--WERDGEIIKPKKNKYDFEKRG---HIRKLYIRNTSVHDEGEYSCILR 1092
V + + D+V W +G +I ++ FE+ G L IRN + G+Y C+++
Sbjct: 521 V-THDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQ 579
Query: 1093 ---DESCTAEVTVVELPP 1107
D A +V PP
Sbjct: 580 TSVDRLSAAADLIVRGPP 597
Score = 82.6 bits (195), Expect = 1e-14
Identities = 131/565 (23%), Positives = 228/565 (40%), Gaps = 53/565 (9%)
Query: 647 EGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE- 705
E + L C + P+P I W G ++ + ++ L I N K Q+
Sbjct: 42 EEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVE------GSLLINNPNKTQDA 95
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES-VILSAQVVGNPRP 764
GTY A N G + K++ + + ++ VR+G+ V+L +
Sbjct: 96 GTYQCTATNSFG-TIVSREAKLQFAYLDNFKT-RTRSTVSVRRGQGMVLLCGPPPHSGEL 153
Query: 765 TITWCKNNKPVKALPTK-SDGDTHSITILKPKKVKDEGVYTLKAENS----EGIAETSAV 819
+ W N P + +T ++ I K +K D G YT N+ + + + +
Sbjct: 154 SYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEK-SDVGNYTCVVTNTVTNHKVLGPPTPL 212
Query: 820 ITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWYRNNEIISPSET 878
I + EP + + +F E KG T+KL NPVP+I W R + P
Sbjct: 213 ILRNDGVMGEYEPKIEV-QFPETVPTAKGATVKLECFALGNPVPTIIWRRADG--KPIAR 269
Query: 879 ITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSY 938
+ I L I N E D+G Y+CVA NS GK+ ++T + +++ + +
Sbjct: 270 KARRHKSNGI-LEIPNFQQE-DAGLYECVAENSRGKNVARGQLTFYAQP-NWIQKINDIH 326
Query: 939 ETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
E + V EC+ + + KW N + + D +I Q D G+
Sbjct: 327 VAME-ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ----GTLNITIVNLSDAGM 381
Query: 997 IKCIVKDQE----TSTMLVVKETIPEFIRKL--QDFEVKEKDVAILEVEINSETADV-VW 1049
+C+ +++ ++ L V P+F R L + VK ++E + + V W
Sbjct: 382 YQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW 441
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELP 1106
++ +I+K + + + G++R I N + D G Y+CI + TA T VV+ P
Sbjct: 442 KKGRDILK-ENERITISEDGNLR---IINVTKSDAGSYTCIATNHFGTASSTGNLVVKDP 497
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKG---DALVRWFKDGSEIQF---SNHIQLTIDGKK 1160
++ + V G ++T D + W +G I F +H + + G+
Sbjct: 498 TRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFE-RVGGQD 556
Query: 1161 Q--KLKIYDCDLDDAGEYSCEVGNS 1183
L I + L AG+Y C V S
Sbjct: 557 SAGDLMIRNIQLKHAGKYVCMVQTS 581
Score = 65.3 bits (152), Expect = 2e-09
Identities = 135/596 (22%), Positives = 230/596 (38%), Gaps = 67/596 (11%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV-KALPTKSDGDTHSIT 790
+EP V+ PL S + + V L+ +V GNP+P I W N V + + S+
Sbjct: 30 QEPSPVMFPLDS----EEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLL 85
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQE-ITVKE-KG 848
I P K +D G Y A NS G I E + A F R + ++V+ +G
Sbjct: 86 INNPNKTQDAGTYQCTATNSFG------TIVSREAKLQFAYLDNFKTRTRSTVSVRRGQG 139
Query: 849 TIKLVARVTRNPVPSITWYRNNEIISPSETITQNF-DGENIELVITNVDSEIDSGDYKCV 907
+ L + S W N PS + F E L I V+ D G+Y CV
Sbjct: 140 MVLLCGPPPHSGELSYAWIFNE---YPSYQDNRRFVSQETGNLYIAKVEKS-DVGNYTCV 195
Query: 908 ASNS-AGKSSHGARVTIDVEKVTFVKHLQKSYE--------TEEGKTVILEC-QTSHTVS 957
+N+ G + + + + E T +G TV LEC + V
Sbjct: 196 VTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVP 255
Query: 958 T-KWYH-NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKET 1015
T W + K I+ R+ + D G+ +C+ ++ + + T
Sbjct: 256 TIIWRRADGKPIA----RKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLT 311
Query: 1016 I---PEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHI 1071
P +I+K+ D V ++ E + N W ++GE + +++ E+
Sbjct: 312 FYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLL-TRDRIQIEQ---- 366
Query: 1072 RKLYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQ--KVNKGNKAT 1125
L I ++ D G Y C+ ++ AE++V+ + P+ L + V G +
Sbjct: 367 GTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVV 426
Query: 1126 FEIELTKGDALVRWFKDGSEIQFSN-HIQLTIDGKKQKLKIYDCDLDDAGEYSC----EV 1180
E + V +K G +I N I ++ DG L+I + DAG Y+C
Sbjct: 427 IECKPKASPKPVYTWKKGRDILKENERITISEDG---NLRIINVTKSDAGSYTCIATNHF 483
Query: 1181 GNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP-DETLDV--TWYKKKSVIE 1237
G + T L V++P+ + P + V L ++ D +LD+ TW +I+
Sbjct: 484 GTASSTGNLVVKDPT--RVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLID 541
Query: 1238 ---DTEKFTLISDVKKR-TLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE-VVEFPP 1288
D + F + L+IR +Y C++ + + +V PP
Sbjct: 542 FDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPP 597
Score = 57.2 bits (132), Expect = 6e-07
Identities = 47/173 (27%), Positives = 68/173 (39%), Gaps = 14/173 (8%)
Query: 1852 TSDDKITIGKTLT---PPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVK 1908
TS D+++ L PP P + E T + L W P + SPIT Y+I+ +T
Sbjct: 580 TSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSW-RPGPDNHSPITMYVIQARTPF 638
Query: 1909 GKSWTKIVTV----GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHAT 1964
W + TV G + + E FR A N +G+ P+ R + A
Sbjct: 639 SVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEAL 698
Query: 1965 VPSPPTAPLEIRMVG---SNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM 2014
P P + G S +V+T PE GY +A R K +WM
Sbjct: 699 ---PEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWM 748
>BC113118-1|AAI13119.1| 1028|Homo sapiens contactin 6 protein.
Length = 1028
Score = 99.5 bits (237), Expect = 1e-19
Identities = 188/929 (20%), Positives = 333/929 (35%), Gaps = 68/929 (7%)
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSI- 1196
RW ++G++I F+ +DG + D D G Y C N T + +
Sbjct: 61 RWKQNGTDIDFTMSYHYRLDGGSLAINSPHTD-QDIGMYQCLATNLLGTILSRKAKLQFA 119
Query: 1197 ---NFTLRLPEFILVPANTDAYLTVEIPDETLDVT--WYKKKSVIEDTEKFTLISDVKKR 1251
+F + + V L P D++ W + + E +
Sbjct: 120 YIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETG 179
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTTKLK------VE-----VVEFPPKI-VDYEREYRI 1299
L I K D YTC + + ++ ++ V+ + E+ PKI V + +
Sbjct: 180 NLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQA 239
Query: 1300 KRGSDVTLLVDYQAFPQPNDEW--IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGI 1357
+ S V L P P+ W + S + K K++K A L I + D G
Sbjct: 240 AKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSK-----SQAILEIPNFQQEDEGF 294
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY-YV 1416
Y+ N G + + P K + S N+ W E + +G Y ++
Sbjct: 295 YECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHL-SIYDNLLW-ECKASGKPNPWYTWL 352
Query: 1417 VEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ ++ E I ++N T T L + S ++ A N+ I A+ +
Sbjct: 353 KNGERLNPEERIQIENGTLIITM---LNVSDSGVYQCAAENKYQIIYANAELRVLASAPD 409
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXX 1535
+SP +K + DI + C P+ ++W R + L+ +K +
Sbjct: 410 FS-KSPVKKKSFVQV----GGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSL 464
Query: 1536 XXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV 1595
Y CIA N G + + + ++++ VIT+ K VG+ ++
Sbjct: 465 KIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPS--KMDVTVGESIVLPCQ 522
Query: 1596 IEGIPPPEVI--WYKNGNKLENDK---EYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
+ P EV+ W+ NG+ ++ K + E + I+ ++ HS KY T
Sbjct: 523 VSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTT 582
Query: 1651 AGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN 1710
+ S + V P PE V + +IS + + W+ D+ + + I+ P +
Sbjct: 583 LESLSAVADIIVRGPPGPPED-VQVEDISSTTSQLSWRAGPDNNS-PIQIFTIQTRTPFS 640
Query: 1711 NRWIKVADVDRDV--ETY--CIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV 1766
W VA V + +TY + L+ EY FRV+A N +G E E + ++T V
Sbjct: 641 VGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSEL-LRTKASV 699
Query: 1767 PSXXXXXXXXXXIDNESVYITW--FPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXX 1823
P + ITW P E G Y + + G W
Sbjct: 700 PVVAPVNIHGGGGSRSELVITWESIPEELQNGEG-FGYIIMFRPVGSTTWSKEKVSSVES 758
Query: 1824 ARI----QKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTS 1879
+R + + + ++ ++ N G S I P PR + ++
Sbjct: 759 SRFVYRNESIIPLSPFEVKVGVYNNEGEG--SLSTVTIVYSGEDEPQLAPRGTSLQSFSA 816
Query: 1880 RSVTLKWTEPESNGGS-PITNYIIEFKTVKGK-SWTKIVTVGGSVHEHCIENIKEKDEII 1937
+ + W N + + Y + + T K S + V G+V I +K
Sbjct: 817 SEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYF 876
Query: 1938 FRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAP 1997
+ A NT G S V + + PS P A + ++ S + + + +
Sbjct: 877 ASVRAYNTAGTG--PSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESE 934
Query: 1998 LLGYNIAIRD--VTKTMWMEVGKVDVNTL 2024
+LGY I R +KT +E L
Sbjct: 935 VLGYKILYRQNRQSKTHILETNNTSAELL 963
Score = 85.4 bits (202), Expect = 2e-15
Identities = 79/328 (24%), Positives = 142/328 (43%), Gaps = 27/328 (8%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P+ + S + LEC + P PDI+W +P + V ++L+I N
Sbjct: 234 PETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGK---VKYSKSQ----AILEIPN 286
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVV 759
++ EG Y +A N G + K + PP+ + +++ + ++++ +
Sbjct: 287 FQQEDEGFYECIASNLRGRN----LAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKAS 342
Query: 760 GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
G P P TW KN + + P + + I+ V D GVY AEN I +A
Sbjct: 343 GKPNPWYTWLKNGERLN--PEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAE 400
Query: 820 ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETI 879
+ V + ++ P+ F V+ G I + + P +I+W R E + S+ I
Sbjct: 401 LRVLASAPDFSKSPVKKKSF----VQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRI 456
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
DG L I N+ + D+G Y C+A+N G + + ++ V++ T + +
Sbjct: 457 FLLEDG---SLKIYNI-TRSDAGSYTCIATNQFGTAKNTG--SLIVKERTVITVPPSKMD 510
Query: 940 TEEGKTVILECQTSHTVSTK----WYHN 963
G++++L CQ SH S + W+ N
Sbjct: 511 VTVGESIVLPCQVSHDPSIEVVFVWFFN 538
Score = 66.1 bits (154), Expect = 1e-09
Identities = 68/302 (22%), Positives = 128/302 (42%), Gaps = 35/302 (11%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + +K + ++ ++L EC+ P P WL GE + P+E I + + +
Sbjct: 317 PPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQI---ENGTLII 373
Query: 693 SVLKITNVKKFQ---EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
++L +++ +Q E Y ++ N A L ++ K P + K V+ G
Sbjct: 374 TMLNVSDSGVYQCAAENKYQIIYAN----AELRVLASAPDFSKSPVK-----KKSFVQVG 424
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+++ + PR I+W + + + K + DG I + D G YT
Sbjct: 425 GDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITR----SDAGSYTCI 480
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI-- 864
A N G A+ + + V+E T P ++TV E +I L +V+ +P +
Sbjct: 481 ATNQFGTAKNTGSLIVKERTVITVPPSK-----MDVTVGE--SIVLPCQVSHDPSIEVVF 533
Query: 865 TWYRNNEIISPSETIT--QNFDGENI-ELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
W+ N ++I + + + GE++ +L+I N+ SG Y C + S A +
Sbjct: 534 VWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLH-HSGKYLCTVQTTLESLSAVADI 592
Query: 922 TI 923
+
Sbjct: 593 IV 594
Score = 59.7 bits (138), Expect = 1e-07
Identities = 125/560 (22%), Positives = 213/560 (38%), Gaps = 52/560 (9%)
Query: 649 SDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE-GT 707
S+++L C P P W G +I D +S D L I + Q+ G
Sbjct: 44 SEVILNCAANGYPSPHYRWKQNGTDI--DFTMSYHYRLDG----GSLAINSPHTDQDIGM 97
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP--- 764
Y +A N G L K++ E + + ++ VR+G+ V+L + G P
Sbjct: 98 YQCLATNLLGTI-LSRKAKLQFAYIEDFET-KTRSTVSVREGQGVVL---LCGPPPHFGD 152
Query: 765 -TITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+ W N+ P+ +T ++ I K + D G YT N E
Sbjct: 153 LSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEP-SDVGNYTCFITNKEAQRSVQGPP 211
Query: 821 T-VEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
T + + T+ EP + + + I + ++KL NPVP I+W R + P
Sbjct: 212 TPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPG 271
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
+ + L I N E D G Y+C+ASN G++ ++ I + + +Q
Sbjct: 272 KV---KYSKSQAILEIPNFQQE-DEGFYECIASNLRGRNLAKGQL-IFYAPPEWEQKIQN 326
Query: 937 SYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
++ ++ EC+ S WY K ++ E IQ D GV
Sbjct: 327 TH-LSIYDNLLWECKASGK-PNPWYTWLKNGERLNPEERIQI-ENGTLIITMLNVSDSGV 383
Query: 997 IKCIVKDQ----ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVVW 1049
+C +++ + L V + P+F + K + F D+ I A + W
Sbjct: 384 YQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISW 443
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELP 1106
+R E ++ K + E G + K+Y N + D G Y+CI ++ TA+ T +V+
Sbjct: 444 KRGTETLRQSKRIFLLED-GSL-KIY--NITRSDAGSYTCIATNQFGTAKNTGSLIVKER 499
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKG---DALVRWFKDGSEIQFSN---HIQLTIDGKK 1160
I V G +++ + + WF +G I H +
Sbjct: 500 TVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESV 559
Query: 1161 QKLKIYDCDLDDAGEYSCEV 1180
L I + L +G+Y C V
Sbjct: 560 GDLMIRNIQLHHSGKYLCTV 579
Score = 58.4 bits (135), Expect = 3e-07
Identities = 49/175 (28%), Positives = 74/175 (42%), Gaps = 11/175 (6%)
Query: 1865 PPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV----GG 1920
PP P + V + +S + L W N SPI + I+ +T W + TV G
Sbjct: 597 PPGPPEDVQVEDISSTTSQLSWRAGPDNN-SPIQIFTIQTRTPFSVGWQAVATVPEILNG 655
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVG- 1979
+ + + E FR+ A N++G+ P+E + L A+VP AP+ I G
Sbjct: 656 KTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSEL-LRTKASVPV--VAPVNIHGGGG 712
Query: 1980 --SNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLS 2032
S +V+T PE GY I R V T W + V + +F R+ S
Sbjct: 713 SRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNES 767
Score = 47.2 bits (107), Expect = 6e-04
Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + C+ +PR I+W R T ++ S+ + D +L I + DAG++TC
Sbjct: 424 GGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLED----GSLKIYNITRSDAGSYTC 479
Query: 584 VAKNAAGFASSTTELIVE 601
+A N G A +T LIV+
Sbjct: 480 IATNQFGTAKNTGSLIVK 497
Score = 45.6 bits (103), Expect = 0.002
Identities = 131/620 (21%), Positives = 230/620 (37%), Gaps = 57/620 (9%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSIT 790
+EP VI PL + + E VIL+ G P P W +N + + D S+
Sbjct: 30 QEPHDVIFPLD---LSKSE-VILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLA 85
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE-KGT 849
I P +D G+Y A N G S ++ E+ E ++V+E +G
Sbjct: 86 INSPHTDQDIGMYQCLATNLLGTI-LSRKAKLQFAYIEDFET----KTRSTVSVREGQGV 140
Query: 850 IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS 909
+ L S W N+ + E + E L I V+ D G+Y C +
Sbjct: 141 VLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPS-DVGNYTCFIT 199
Query: 910 NSAGKSSHGARVTIDVEKVTFVK---------HLQKSYETEEGKTVILECQTSHTVSTKW 960
N + S T V++ V ++ + + +V LEC
Sbjct: 200 NKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDI 259
Query: 961 YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTML---VVKETIP 1017
+ + S + + + + D G +CI + + ++ P
Sbjct: 260 SWRRLDGSPLPGKVKYSKSQAILEIPNFQQE-DEGFYECIASNLRGRNLAKGQLIFYAPP 318
Query: 1018 EFIRKLQDFEVKEKDVAILEVEINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYI 1076
E+ +K+Q+ + D + E + + + W ++GE + P++ + E L I
Sbjct: 319 EWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEE-RIQIENG----TLII 373
Query: 1077 RNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQK--VNKGNKATFEIEL 1130
+V D G Y C ++ AE+ V+ P+ +K V G +
Sbjct: 374 TMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKP 433
Query: 1131 TKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKC 1185
A + W + ++ S I L DG LKIY+ DAG Y+C + G +K
Sbjct: 434 NAFPRAAISWKRGTETLRQSKRIFLLEDGS---LKIYNITRSDAGSYTCIATNQFGTAKN 490
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP-DETLDV--TWYKKKSVIE---DT 1239
T L V+E ++ T+ P + V L ++ D +++V W+ VI+
Sbjct: 491 TGSLIVKERTV-ITVP-PSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGV 548
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTC-VLLDAKSTTKLKVEVVEFPPKIVDYEREYR 1298
F I L+IR +Y C V +S + + +V PP + +
Sbjct: 549 AHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPP---GPPEDVQ 605
Query: 1299 IKRGSDVTLLVDYQAFPQPN 1318
++ S T + ++A P N
Sbjct: 606 VEDISSTTSQLSWRAGPDNN 625
Score = 43.6 bits (98), Expect = 0.008
Identities = 26/97 (26%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P + +K++ H + +EC+ G P P TW + + P + Q+ +N TL+
Sbjct: 318 PEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQI----EN-GTLI 372
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I + D+G + C A+N + EL V A D
Sbjct: 373 ITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPD 409
Score = 36.7 bits (81), Expect = 0.91
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 4/79 (5%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S+V+ EC G P P I+W R P + + Y A L I ED G + C+
Sbjct: 243 SSVKLECFALGNPVPDISWRRLDGSPLPGK---VKYSKSQ-AILEIPNFQQEDEGFYECI 298
Query: 585 AKNAAGFASSTTELIVEAP 603
A N G + +LI AP
Sbjct: 299 ASNLRGRNLAKGQLIFYAP 317
Score = 35.1 bits (77), Expect = 2.8
Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 7/115 (6%)
Query: 1949 SLPTESQSVRLEKHATVPSPPTAPLEIRM--VGSNIVMTSWGTPEWDGGAPLLGYNIAIR 2006
++ T +S+ V PP P ++++ + S SW D +P+ + I R
Sbjct: 578 TVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGP-DNNSPIQIFTIQTR 636
Query: 2007 DVTKTMWMEVGKVD--VNTLKFN--IRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
W V V +N +N + LS Y R+ A N IG+ EP E E
Sbjct: 637 TPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSE 691
>BC045763-1|AAH45763.1| 1329|Homo sapiens SDK2 protein protein.
Length = 1329
Score = 99.5 bits (237), Expect = 1e-19
Identities = 99/406 (24%), Positives = 178/406 (43%), Gaps = 31/406 (7%)
Query: 1658 VTLKVYDKPSKPEGPVIMRE-ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW-IK 1715
VT + D+P P P++ +E + SV + W+P DG + Y I+ E + RW +
Sbjct: 568 VTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPG-SDGLSPVRYYTIQTRELPSGRWALH 626
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXX 1775
A V + ++ + +L Y FRV A N +G SE E E + T P
Sbjct: 627 SASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE-ESESLTTLQAAPDEAPTILS 685
Query: 1776 XXXIDNESVYITWF-PSEKNGGSPIIDYKV---EIKQEGKK---WKXXXXXXXXXARIQK 1828
SV I W P+E ++ +++ E+ EG + + A +
Sbjct: 686 VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFMLRGINNPGATWAELTY 745
Query: 1829 LSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTE 1888
L+ + Y+ R+ N +G P + ++ +G+ + P + PRN VV +T+ + + W
Sbjct: 746 LNKHRRYEIRMSVYNAVGEG-PSSPPQEVFVGEAV-PTAAPRNVVVHGATATQLDVTWEP 803
Query: 1889 P--ESNGGSPITNYIIEF-KTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENT 1945
P +S G I Y I F + +G ++ T+ + + ++N+ + ++A N
Sbjct: 804 PPLDSQNGD-IQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 862
Query: 1946 VG---VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYN 2002
G S PT+ Q+ PS P++ ++ + + V SW P++ G L GY
Sbjct: 863 AGDGPRSTPTQGQT-----QQAAPSAPSS-VKFSELTTTSVNVSWEAPQFPNGI-LEGYR 915
Query: 2003 IAIRDVTKTMWM-EVGKVDV---NTLKFNIRDLSENHTYMIRIYAR 2044
+ + + ++ VDV + L ++DL+E TY RI A+
Sbjct: 916 LVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAK 961
Score = 68.1 bits (159), Expect = 3e-10
Identities = 100/439 (22%), Positives = 169/439 (38%), Gaps = 39/439 (8%)
Query: 1643 YTIEASNTAGTSSVEVTLKVYDKPSKPE--GPVIMREISR---ESVTIEWKPPLDDGGLE 1697
YTIE + +V+ PE GP IS SVT++++P D G
Sbjct: 140 YTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYD-GKTS 198
Query: 1698 LTKYAIEKHEP---DNNRWIKVADVDR--DVETYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
++++ +E + W+ + + D + + LN Y FR+ N VG S
Sbjct: 199 ISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPP 258
Query: 1753 LESEPI-VIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSPIIDYKVEIKQ 1808
S+P I+T P S+++ W P E NG + YK++ +
Sbjct: 259 --SQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSR 316
Query: 1809 EGKKWKXXXXXXXXXAR----IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTL- 1863
K I+ L T Y+ ++ A N IG+ P++ + +G+T
Sbjct: 317 SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSG-PWS---QTVVGRTRE 372
Query: 1864 -TPPSQPRNFVVSESTSRSVTLKWTE-PESNGGSPITNYIIEFKTVKGKSWTKIVTV-GG 1920
P S P N +TS S+ ++W+E PE++ + Y + +K + + V G
Sbjct: 373 SVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 432
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHA-TVPSPPTAPL--EIRM 1977
S + + + ++ A +G P S LE+ VP PP L E+R
Sbjct: 433 SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP--SHPPILERTLDDVPGPPMGILFPEVRT 490
Query: 1978 VGSNIVMTSWGTPEWDGGAPLLGYNIAIR-DVTKTMWMEVGKVDVNTLKFNIRDLSENHT 2036
++ W P G +L Y I R + T V + + ++ L
Sbjct: 491 TSVRLI---WQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESV 546
Query: 2037 YMIRIYARNEIGLSEPLES 2055
Y+ RI A+ G E E+
Sbjct: 547 YLFRITAQTRKGWGEAAEA 565
Score = 67.7 bits (158), Expect = 4e-10
Identities = 91/414 (21%), Positives = 157/414 (37%), Gaps = 19/414 (4%)
Query: 1652 GTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNN 1711
G S ++ ++ P G + EI S+ + W+ P + G+ LT Y I E +
Sbjct: 56 GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRT 114
Query: 1712 RWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXX 1771
+ Y + L Y V A G + + + I ++P
Sbjct: 115 NTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTISSGVPPELPG-PP 172
Query: 1772 XXXXXXXIDNESVYITWFPSEKNGGSP---IIDYKVEIKQEGKKW----KXXXXXXXXXA 1824
I SV + + P S +++ +V + EG++W +
Sbjct: 173 TNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSM 232
Query: 1825 RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTL 1884
+ L+ T Y FR+ N +GTS P KI + P P N + ++ S+ L
Sbjct: 233 EVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQA-PPDMAPANVSLRTASETSLWL 291
Query: 1885 KW---TEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSV-HEHCIENIKEKDEIIFRI 1940
+W E E NG Y I++ G T V V ++ IE+++E E ++
Sbjct: 292 RWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQV 351
Query: 1941 SAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWG-TPEWDGGAPLL 1999
A N +G S P SQ+V +VPS + S+ ++ W PE D +L
Sbjct: 352 QAFNAIG-SGPW-SQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVL 409
Query: 2000 GYNIAIRDVTKTMWMEVGKVDVNTLK-FNIRDLSENHTYMIRIYARNEIGLSEP 2052
GY + ++ V+ N+ + + L + Y +++ A IG P
Sbjct: 410 GYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP 463
Score = 60.9 bits (141), Expect = 5e-08
Identities = 33/120 (27%), Positives = 65/120 (54%), Gaps = 6/120 (5%)
Query: 1379 DKPSPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITK 1435
D+P PP +P + + D + S+ + W EP + G S + YY ++ +E+ + W + +++
Sbjct: 574 DRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSH 632
Query: 1436 TQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITT 1493
+S + LK +SY+FR A N++ S+ SE +E ++ ++PT+ + TT
Sbjct: 633 NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTT 692
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/126 (27%), Positives = 55/126 (43%), Gaps = 9/126 (7%)
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV---YDKPSKPEGPVIMREISRESVTIE 1686
+++K+L + ++ I A +E + P P P+I+R S ++ I
Sbjct: 943 LKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSS--AIAIH 1000
Query: 1687 WKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQK--LNENCEYMFRVIA 1743
W D G +T+Y IE D W I + D+ ++V +Y L Y FRVIA
Sbjct: 1001 WSSG-DPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1059
Query: 1744 QNPVGF 1749
N GF
Sbjct: 1060 VNDYGF 1065
Score = 48.8 bits (111), Expect = 2e-04
Identities = 44/144 (30%), Positives = 67/144 (46%), Gaps = 13/144 (9%)
Query: 1337 SIDSKSASLTIKKVENTDAGI---YKLRLENNCGHADVEMNVTI---LDKPSPPGKPNIL 1390
++D K S KV++ G+ +++R + ++E NVT P PPG P I+
Sbjct: 932 TVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIV 991
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTS----IQNLKT 1445
SS+I I W + G I YV+E + D W I +K+I K +S + LK
Sbjct: 992 RY-SSAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKP 1049
Query: 1446 NSSYRFRAYAVNEVDISDASETTE 1469
SY FR AVN+ S ++
Sbjct: 1050 GVSYDFRVIAVNDYGFGTPSSPSQ 1073
>AB003592-1|BAA82612.1| 1028|Homo sapiens neural adhesion molecule
NB-3 protein.
Length = 1028
Score = 99.5 bits (237), Expect = 1e-19
Identities = 188/929 (20%), Positives = 333/929 (35%), Gaps = 68/929 (7%)
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSI- 1196
RW ++G++I F+ +DG + D D G Y C N T + +
Sbjct: 61 RWKQNGTDIDFTMSYHYRLDGGSLAINSPHTD-QDIGMYQCLATNLLGTILSRKAKLQFA 119
Query: 1197 ---NFTLRLPEFILVPANTDAYLTVEIPDETLDVT--WYKKKSVIEDTEKFTLISDVKKR 1251
+F + + V L P D++ W + + E +
Sbjct: 120 YIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETG 179
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTTKLK------VE-----VVEFPPKI-VDYEREYRI 1299
L I K D YTC + + ++ ++ V+ + E+ PKI V + +
Sbjct: 180 NLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQA 239
Query: 1300 KRGSDVTLLVDYQAFPQPNDEW--IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGI 1357
+ S V L P P+ W + S + K K++K A L I + D G
Sbjct: 240 AKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSK-----SQAILEIPNFQQEDEGF 294
Query: 1358 YKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY-YV 1416
Y+ N G + + P K + S N+ W E + +G Y ++
Sbjct: 295 YECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHL-SIYDNLLW-ECKASGKPNPWYTWL 352
Query: 1417 VEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKE 1476
+ ++ E I ++N T T L + S ++ A N+ I A+ +
Sbjct: 353 KNGERLNPEERIQIENGTLIITM---LNVSDSGVYQCAAENKYQIIYANAELRVLASAPD 409
Query: 1477 TKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXX 1535
+SP +K + DI + C P+ ++W R + L+ +K +
Sbjct: 410 FS-KSPVKKKSFVQV----GGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSL 464
Query: 1536 XXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV 1595
Y CIA N G + + + ++++ VIT+ K VG+ ++
Sbjct: 465 KIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPS--KMDVTVGESIVLPCQ 522
Query: 1596 IEGIPPPEVI--WYKNGNKLENDK---EYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
+ P EV+ W+ NG+ ++ K + E + I+ ++ HS KY T
Sbjct: 523 VSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTT 582
Query: 1651 AGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDN 1710
+ S + V P PE V + +IS + + W+ D+ + + I+ P +
Sbjct: 583 LESLSAVADIIVRGPPGPPED-VQVEDISSTTSQLSWRAGPDNNS-PIQIFTIQTRTPFS 640
Query: 1711 NRWIKVADVDRDV--ETY--CIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDV 1766
W VA V + +TY + L+ EY FRV+A N +G E E + ++T V
Sbjct: 641 VGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSEL-LRTKASV 699
Query: 1767 PSXXXXXXXXXXIDNESVYITW--FPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXX 1823
P + ITW P E G Y + + G W
Sbjct: 700 PVVAPVNIHGGGGSRSELVITWESIPEELQNGEG-FGYIIMFRPVGSTTWSKEKVSSVES 758
Query: 1824 ARI----QKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTS 1879
+R + + + ++ ++ N G S I P PR + ++
Sbjct: 759 SRFVYRNESIIPLSPFEVKVGVYNNEGEG--SLSTVTIVYSGEDEPQLAPRGTSLQSFSA 816
Query: 1880 RSVTLKWTEPESNGGS-PITNYIIEFKTVKGK-SWTKIVTVGGSVHEHCIENIKEKDEII 1937
+ + W N + + Y + + T K S + V G+V I +K
Sbjct: 817 SEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYF 876
Query: 1938 FRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAP 1997
+ A NT G S V + + PS P A + ++ S + + + +
Sbjct: 877 ASVRAYNTAGTG--PSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESE 934
Query: 1998 LLGYNIAIRD--VTKTMWMEVGKVDVNTL 2024
+LGY I R +KT +E L
Sbjct: 935 VLGYKILYRQNRQSKTHILETNNTSAELL 963
Score = 85.4 bits (202), Expect = 2e-15
Identities = 79/328 (24%), Positives = 142/328 (43%), Gaps = 27/328 (8%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P+ + S + LEC + P PDI+W +P + V ++L+I N
Sbjct: 234 PETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGK---VKYSKSQ----AILEIPN 286
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVV 759
++ EG Y +A N G + K + PP+ + +++ + ++++ +
Sbjct: 287 FQQEDEGFYECIASNLRGRN----LAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKAS 342
Query: 760 GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
G P P TW KN + + P + + I+ V D GVY AEN I +A
Sbjct: 343 GKPNPWYTWLKNGERLN--PEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAE 400
Query: 820 ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETI 879
+ V + ++ P+ F V+ G I + + P +I+W R E + S+ I
Sbjct: 401 LRVLASAPDFSKSPVKKKSF----VQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRI 456
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
DG L I N+ + D+G Y C+A+N G + + ++ V++ T + +
Sbjct: 457 FLLEDG---SLKIYNI-TRSDAGSYTCIATNQFGTAKNTG--SLIVKERTVITVPPSKMD 510
Query: 940 TEEGKTVILECQTSHTVSTK----WYHN 963
G++++L CQ SH S + W+ N
Sbjct: 511 VTVGESIVLPCQVSHDPSIEVVFVWFFN 538
Score = 66.1 bits (154), Expect = 1e-09
Identities = 68/302 (22%), Positives = 128/302 (42%), Gaps = 35/302 (11%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP + +K + ++ ++L EC+ P P WL GE + P+E I + + +
Sbjct: 317 PPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQI---ENGTLII 373
Query: 693 SVLKITNVKKFQ---EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
++L +++ +Q E Y ++ N A L ++ K P + K V+ G
Sbjct: 374 TMLNVSDSGVYQCAAENKYQIIYAN----AELRVLASAPDFSKSPVK-----KKSFVQVG 424
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+++ + PR I+W + + + K + DG I + D G YT
Sbjct: 425 GDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITR----SDAGSYTCI 480
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI-- 864
A N G A+ + + V+E T P ++TV E +I L +V+ +P +
Sbjct: 481 ATNQFGTAKNTGSLIVKERTVITVPPSK-----MDVTVGE--SIVLPCQVSHDPSIEVVF 533
Query: 865 TWYRNNEIISPSETIT--QNFDGENI-ELVITNVDSEIDSGDYKCVASNSAGKSSHGARV 921
W+ N ++I + + + GE++ +L+I N+ SG Y C + S A +
Sbjct: 534 VWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLH-HSGKYLCTVQTTLESLSAVADI 592
Query: 922 TI 923
+
Sbjct: 593 IV 594
Score = 59.7 bits (138), Expect = 1e-07
Identities = 125/560 (22%), Positives = 213/560 (38%), Gaps = 52/560 (9%)
Query: 649 SDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQE-GT 707
S+++L C P P W G +I D +S D L I + Q+ G
Sbjct: 44 SEVILNCAANGYPSPHYRWKQNGTDI--DFTMSYHYRLDG----GSLAINSPHTDQDIGM 97
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP--- 764
Y +A N G L K++ E + + ++ VR+G+ V+L + G P
Sbjct: 98 YQCLATNLLGTI-LSRKAKLQFAYIEDFET-KTRSTVSVREGQGVVL---LCGPPPHFGD 152
Query: 765 -TITWCKNNKPVKALPTKS---DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVI 820
+ W N+ P+ +T ++ I K + D G YT N E
Sbjct: 153 LSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEP-SDVGNYTCFITNKEAQRSVQGPP 211
Query: 821 T-VEEPTEE---NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
T + + T+ EP + + + I + ++KL NPVP I+W R + P
Sbjct: 212 TPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPG 271
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
+ + L I N E D G Y+C+ASN G++ ++ I + + +Q
Sbjct: 272 KV---KYSKSQAILEIPNFQQE-DEGFYECIASNLRGRNLAKGQL-IFYAPPEWEQKIQN 326
Query: 937 SYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
++ ++ EC+ S WY K ++ E IQ D GV
Sbjct: 327 TH-LSIYDNLLWECKASGK-PNPWYTWLKNGERLNPEERIQI-ENGTLIITMLNVSDSGV 383
Query: 997 IKCIVKDQ----ETSTMLVVKETIPEFIR---KLQDFEVKEKDVAILEVEINSETADVVW 1049
+C +++ + L V + P+F + K + F D+ I A + W
Sbjct: 384 YQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISW 443
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELP 1106
+R E ++ K + E G + K+Y N + D G Y+CI ++ TA+ T +V+
Sbjct: 444 KRGTETLRQSKRIFLLED-GSL-KIY--NITRSDAGSYTCIATNQFGTAKNTGSLIVKER 499
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKG---DALVRWFKDGSEIQFSN---HIQLTIDGKK 1160
I V G +++ + + WF +G I H +
Sbjct: 500 TVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESV 559
Query: 1161 QKLKIYDCDLDDAGEYSCEV 1180
L I + L +G+Y C V
Sbjct: 560 GDLMIRNIQLHHSGKYLCTV 579
Score = 58.4 bits (135), Expect = 3e-07
Identities = 49/175 (28%), Positives = 74/175 (42%), Gaps = 11/175 (6%)
Query: 1865 PPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV----GG 1920
PP P + V + +S + L W N SPI + I+ +T W + TV G
Sbjct: 597 PPGPPEDVQVEDISSTTSQLSWRAGPDNN-SPIQIFTIQTRTPFSVGWQAVATVPEILNG 655
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVG- 1979
+ + + E FR+ A N++G+ P+E + L A+VP AP+ I G
Sbjct: 656 KTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSEL-LRTKASVPV--VAPVNIHGGGG 712
Query: 1980 --SNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLS 2032
S +V+T PE GY I R V T W + V + +F R+ S
Sbjct: 713 SRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNES 767
Score = 47.2 bits (107), Expect = 6e-04
Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + C+ +PR I+W R T ++ S+ + D +L I + DAG++TC
Sbjct: 424 GGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLED----GSLKIYNITRSDAGSYTC 479
Query: 584 VAKNAAGFASSTTELIVE 601
+A N G A +T LIV+
Sbjct: 480 IATNQFGTAKNTGSLIVK 497
Score = 45.6 bits (103), Expect = 0.002
Identities = 131/620 (21%), Positives = 230/620 (37%), Gaps = 57/620 (9%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK-ALPTKSDGDTHSIT 790
+EP VI PL + + E VIL+ G P P W +N + + D S+
Sbjct: 30 QEPHDVIFPLD---LSKSE-VILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLA 85
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE-KGT 849
I P +D G+Y A N G S ++ E+ E ++V+E +G
Sbjct: 86 INSPHTDQDIGMYQCLATNLLGTI-LSRKAKLQFAYIEDFET----KTRSTVSVREGQGV 140
Query: 850 IKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS 909
+ L S W N+ + E + E L I V+ D G+Y C +
Sbjct: 141 VLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPS-DVGNYTCFIT 199
Query: 910 NSAGKSSHGARVTIDVEKVTFVK---------HLQKSYETEEGKTVILECQTSHTVSTKW 960
N + S T V++ V ++ + + +V LEC
Sbjct: 200 NKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDI 259
Query: 961 YHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTML---VVKETIP 1017
+ + S + + + + D G +CI + + ++ P
Sbjct: 260 SWRRLDGSPLPGKVKYSKSQAILEIPNFQQE-DEGFYECIASNLRGRNLAKGQLIFYAPP 318
Query: 1018 EFIRKLQDFEVKEKDVAILEVEINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYI 1076
E+ +K+Q+ + D + E + + + W ++GE + P++ + E L I
Sbjct: 319 EWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEE-RIQIENG----TLII 373
Query: 1077 RNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQK--VNKGNKATFEIEL 1130
+V D G Y C ++ AE+ V+ P+ +K V G +
Sbjct: 374 TMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKP 433
Query: 1131 TKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKC 1185
A + W + ++ S I L DG LKIY+ DAG Y+C + G +K
Sbjct: 434 NAFPRAAISWKRGTETLRQSKRIFLLEDGS---LKIYNITRSDAGSYTCIATNQFGTAKN 490
Query: 1186 TAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP-DETLDV--TWYKKKSVIE---DT 1239
T L V+E ++ T+ P + V L ++ D +++V W+ VI+
Sbjct: 491 TGSLIVKERTV-ITVP-PSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGV 548
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTC-VLLDAKSTTKLKVEVVEFPPKIVDYEREYR 1298
F I L+IR +Y C V +S + + +V PP + +
Sbjct: 549 AHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPP---GPPEDVQ 605
Query: 1299 IKRGSDVTLLVDYQAFPQPN 1318
++ S T + ++A P N
Sbjct: 606 VEDISSTTSQLSWRAGPDNN 625
Score = 43.6 bits (98), Expect = 0.008
Identities = 26/97 (26%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P + +K++ H + +EC+ G P P TW + + P + Q+ +N TL+
Sbjct: 318 PEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQI----EN-GTLI 372
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I + D+G + C A+N + EL V A D
Sbjct: 373 ITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPD 409
Score = 36.7 bits (81), Expect = 0.91
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 4/79 (5%)
Query: 525 STVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCV 584
S+V+ EC G P P I+W R P + + Y A L I ED G + C+
Sbjct: 243 SSVKLECFALGNPVPDISWRRLDGSPLPGK---VKYSKSQ-AILEIPNFQQEDEGFYECI 298
Query: 585 AKNAAGFASSTTELIVEAP 603
A N G + +LI AP
Sbjct: 299 ASNLRGRNLAKGQLIFYAP 317
Score = 35.1 bits (77), Expect = 2.8
Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 7/115 (6%)
Query: 1949 SLPTESQSVRLEKHATVPSPPTAPLEIRM--VGSNIVMTSWGTPEWDGGAPLLGYNIAIR 2006
++ T +S+ V PP P ++++ + S SW D +P+ + I R
Sbjct: 578 TVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGP-DNNSPIQIFTIQTR 636
Query: 2007 DVTKTMWMEVGKVD--VNTLKFN--IRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
W V V +N +N + LS Y R+ A N IG+ EP E E
Sbjct: 637 TPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSE 691
>BC104812-1|AAI04813.1| 1501|Homo sapiens protein tyrosine
phosphatase, receptor type, S protein.
Length = 1501
Score = 99.1 bits (236), Expect = 2e-19
Identities = 108/530 (20%), Positives = 198/530 (37%), Gaps = 37/530 (6%)
Query: 1473 VIKETKIQS--PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD----GKKLKTAK 1526
V++E ++ S P ++ + E + C G P P++TW++D +
Sbjct: 124 VLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGR 183
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV 1586
Y+C+A N G +S + + + H++
Sbjct: 184 IKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEI 243
Query: 1587 --GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
G +T V G P P V W + L + + + +V+ + ++K S+ YT
Sbjct: 244 MPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPV----GRNVLELTDVK--DSANYT 297
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
A ++ G + V P P P++ E + S+TI W D G + Y +
Sbjct: 298 CVAMSSLGVIEAVAQITVKSLPKAPGTPMV-TENTATSITITW----DSGNPDPVSYYVI 352
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTAL 1764
+++ + D Y I L+ N EY V A N +G + SE +V +T
Sbjct: 353 EYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG--QGPPSESVVTRTGE 410
Query: 1765 DVPSXXXXXXXXXXIDNESVYITW-FPSEKNG--GSPIIDYKVEIKQEGKKWKXXXXXXX 1821
P+ + ++ + W P E NG + Y +E + W+
Sbjct: 411 QAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDS 470
Query: 1822 XXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS 1881
+ L + TY R+ A +G P + D I + P QP N + S
Sbjct: 471 LLTTVGSLLEDETYTVRVLAFTSVGDG-PLS--DPIQVKTQQGVPGQPMNLRAEARSETS 527
Query: 1882 VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRIS 1941
+TL W+ P I Y + F+ +G ++ + +E++K E FR++
Sbjct: 528 ITLSWSPPRQES---IIKYELLFR--EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLA 582
Query: 1942 AENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPE 1991
A + G+ T + + T+ S +++M+ V+ SW P+
Sbjct: 583 ARSPQGLGAFTP-----VVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPD 627
Score = 88.6 bits (210), Expect = 2e-16
Identities = 144/659 (21%), Positives = 253/659 (38%), Gaps = 58/659 (8%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID-SKSA 1343
E PP+ + ++ G + + P+P W K + + D S A
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGA 89
Query: 1344 SLTIKKVENT-DAGIYKLRLENNCGHADVEMNVTILDKPS-PPGKPNI--------LEID 1393
L I+ + D +Y+ +N+ G V +T+L + P G PNI +E
Sbjct: 90 VLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERT 149
Query: 1394 SSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWIS-VKNITKTQTSIQNLKTNSSYRF 1451
++ +C +GN I + ++ +D + +K + I++ + ++
Sbjct: 150 RTATMLC----AASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKY 205
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQP 1511
A N + +S Y +V ++ P+ + P ++ +TC+ G P P
Sbjct: 206 ECVATNSAGVRYSSPANLYVRV---RRVAPRFSILPMSH-EIMPGGNVNITCVAVGSPMP 261
Query: 1512 KVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
V W + + L R Y C+A + G +E + ++ P
Sbjct: 262 YVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSAN--YTCVAMSSLGVIEAVAQITVKSLP 319
Query: 1572 VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN-DKEYNITTKEKTSVI 1630
+ + +T + P V +Y K ++ D Y I T+
Sbjct: 320 KAP-GTPMVTENTATS----ITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRY 374
Query: 1631 RIKELKRSHSSKYTIEASNTAGT---SSVEVTLKVYDKPSKPEGPVIMREISRESVTIEW 1687
I L + + + A N+ G S VT P+ V R +S ++ ++W
Sbjct: 375 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 434
Query: 1688 KPPLDDGGL---ELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
+ P++ GL Y +E P N W K +VD + T + L E+ Y RV+A
Sbjct: 435 EEPVEPNGLIRGYRVYYTMEPEHPVGN-WQK-HNVDDSLLT-TVGSLLEDETYTVRVLAF 491
Query: 1745 NPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKV 1804
VG + S+PI +KT VP + S+ ++W P + II Y++
Sbjct: 492 TSVG--DGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPPRQES---IIKYEL 545
Query: 1805 EIKQEGKKWKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKT 1862
+ +EG + ++ L NT Y FR+ AR+ G +T + +T
Sbjct: 546 -LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGA-FTP---VVRQRT 600
Query: 1863 LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK----TVKGKSWTKIVT 1917
L S P+NF V SV L W P+ N SP T Y I++ V G++ K++T
Sbjct: 601 LQSIS-PKNFKVKMIMKTSVLLSWEFPD-NYNSP-TPYKIQYNGLTLDVDGRTTKKLIT 656
Score = 82.6 bits (195), Expect = 1e-14
Identities = 72/264 (27%), Positives = 117/264 (44%), Gaps = 10/264 (3%)
Query: 717 GEASLPIVLKIK-TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
G L +VL + +EPP+ I+ K I G Q G+P+P +TW K K V
Sbjct: 14 GPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKV 73
Query: 776 KALPTKS---DGDTHSITILKPKKV-KDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ ++ D ++ ++P + +DE VY A+NS G A +TV + +
Sbjct: 74 NSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSG 133
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELV 891
P Q V+ T ++ + NP P ITW+++ + PS + + + L
Sbjct: 134 FPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQ 193
Query: 892 ITNVDSEIDSGDYKCVASNSAG-KSSHGARVTIDVEKVT-FVKHLQKSYETEEGKTVILE 949
I + E D G Y+CVA+NSAG + S A + + V +V L S+E G V +
Sbjct: 194 IES-SEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNIT 252
Query: 950 CQT--SHTVSTKWYHNKKEISGMD 971
C S KW ++++ D
Sbjct: 253 CVAVGSPMPYVKWMQGAEDLTPED 276
Score = 81.8 bits (193), Expect = 2e-14
Identities = 82/337 (24%), Positives = 140/337 (41%), Gaps = 34/337 (10%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++ + + G F CQ G P+P++TW ++ + + + +D+ A L
Sbjct: 33 PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 570 IREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I+ + P D + CVA+N+ G E+ V A L+ D
Sbjct: 93 IQPLRTPRDENVYECVAQNSVG------EITVHAKLT-----------------VLREDQ 129
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
L P P+ + V+ + C P+P+I W FK + +P + S +
Sbjct: 130 LPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITW-FK--DFLPVDP-SASNGRIK 185
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREG-EASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ L+I + ++ +G Y VA N G S P L ++ P I P+ I+
Sbjct: 186 QLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIM- 244
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKA 807
G +V ++ VG+P P + W + + + T D +L+ VKD YT A
Sbjct: 245 PGGNVNITCVAVGSPMPYVKWMQGAEDL----TPEDDMPVGRNVLELTDVKDSANYTCVA 300
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITV 844
+S G+ E A ITV+ + P + N IT+
Sbjct: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI 337
Score = 80.2 bits (189), Expect = 7e-14
Identities = 75/299 (25%), Positives = 127/299 (42%), Gaps = 23/299 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F K+PK Q G C+ P+P + W KG+++ + IE D
Sbjct: 32 PPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKV--NSQRFETIEFD-ESAG 88
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
+VL+I ++ E Y VA N GE ++ L + ++ P P + + +V +
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYT 804
+ + GNP P ITW K+ PV P+ S+G + ++ + D+G Y
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVD--PSASNGRIKQLRSGALQIESSEETDQGKYE 206
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
A NS G+ +S P F + G + + +P+P +
Sbjct: 207 CVATNSAGVRYSSPANLY---VRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYV 263
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W + E ++P + + G N+ L +T+V DS +Y CVA +S G A++T+
Sbjct: 264 KWMQGAEDLTPEDDMPV---GRNV-LELTDVK---DSANYTCVAMSSLGVIEAVAQITV 315
Score = 79.4 bits (187), Expect = 1e-13
Identities = 92/385 (23%), Positives = 148/385 (38%), Gaps = 32/385 (8%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQ 1161
E PP I ++Q G A+F + T GD R W K G ++ + D
Sbjct: 30 EEPPRFIKEPKDQIGVSGGVASFVCQAT-GDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 1162 K-LKIYDCDLD-DAGEYSCEVGNS--------KCTAILTVEEPSINFTLRL-PEFILVP- 1209
L+I D Y C NS K T + + PS + + P+ +V
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
T L + ++TW+K ++ + I ++ L I E DQ +Y CV
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 208
Query: 1270 LLDA-----KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
++ S L V V P+ + I G +V + P P +W+
Sbjct: 209 ATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQG 268
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
++ + P D ++ + D+ Y ++ G + +T+ P P
Sbjct: 269 AEDLT------PEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP 322
Query: 1385 GKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWISVK-NITKTQTSIQN 1442
G P + E ++SI I WD +GN + YYV+EY+ +K +IT T+ SI
Sbjct: 323 GTPMVTENTATSITITWD----SGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGG 378
Query: 1443 LKTNSSYRFRAYAVNEVDISDASET 1467
L NS Y AVN + SE+
Sbjct: 379 LSPNSEYEIWVSAVNSIGQGPPSES 403
Score = 63.7 bits (148), Expect = 7e-09
Identities = 51/218 (23%), Positives = 101/218 (46%), Gaps = 12/218 (5%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P +V+E+T+ S+T+ W +S P++ Y+IE+K+ K + + + +
Sbjct: 319 PKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKS-KSQDGPYQIKEDITTTRY 374
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMT 1985
I + E +SA N++G P+ES R + A +P ++ RM+ + ++
Sbjct: 375 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRN--VQARMLSATTMIV 432
Query: 1986 SWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN-TLKFNIRDLSENHTYMIRIYAR 2044
W P G + GY + + K +V+ +L + L E+ TY +R+ A
Sbjct: 433 QWEEPVEPNGL-IRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAF 491
Query: 2045 NEIG---LSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
+G LS+P++ + + +PG+ + E +T +
Sbjct: 492 TSVGDGPLSDPIQV-KTQQGVPGQPMNLRAEARSETSI 528
>BC052946-1|AAH52946.1| 837|Homo sapiens neural cell adhesion
molecule 2 protein.
Length = 837
Score = 99.1 bits (236), Expect = 2e-19
Identities = 139/660 (21%), Positives = 256/660 (38%), Gaps = 45/660 (6%)
Query: 1215 YLTVEIPDETLDVTWYKKKSV-IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
+ T E + WY + I T++ + + + L I +D Y C DA
Sbjct: 39 FFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDA 98
Query: 1274 KSTTKLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC 1331
K T+ V+E K+ E K+G D ++ + P P W+ +++ +
Sbjct: 99 KGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTI 158
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKL--RLENNCGHADVEMNVTILDKPSPPGKP-- 1387
+ ++ + + +L I + +D GIY+ R+E G D + I++ P P
Sbjct: 159 SDNRFAMLANN-NLQILNINKSDEGIYRCEGRVEAR-GEIDFRDIIVIVNVPPAISMPQK 216
Query: 1388 NILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNS 1447
+ + + + I + + I+ E +K + T+ +++N+ +
Sbjct: 217 SFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG-SNTELTVRNIINSD 275
Query: 1448 SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
+ A N+ + E + +V +Q ++ LKN TT N + L C G
Sbjct: 276 GGPYVCRATNK---AGEDEKQAFLQVF----VQPHIIQ--LKNETTYENGQVTLVCDAEG 326
Query: 1508 VPQPKVTWYR--DGKKLKTAKATYENRXXXXXXXXXXXX---------XXXYKCIAFNDH 1556
P P++TW R DG + + R Y C A +
Sbjct: 327 EPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRI 386
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
G + S + I+ P ISN+ I + G+ ++ ++ PP + W ++ L
Sbjct: 387 GGHQKSMYLDIEYAPKF-ISNQTIYYSWE-GNPINISCDVKSNPPASIHWRRDKLVLPAK 444
Query: 1617 KEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI 1674
N+ T + ++ I + +Y A+N GT E L + D PS P G I
Sbjct: 445 NTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKI 504
Query: 1675 MREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCI-QKLNE 1733
+ E+S+ + + + P GG+ + Y ++ E + W V V+T + L
Sbjct: 505 I-ELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVR--SHGVQTMVVLNNLEP 561
Query: 1734 NCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEK 1793
N Y RV A N G + + E I + PS + + IT +
Sbjct: 562 NTTYEIRVAAVNGKGQGDYSKIE-IFQTLPVREPSPPSIHGQPSSGKSFKLSIT---KQD 617
Query: 1794 NGGSPIIDYKVEIKQEGK--KW-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+GG+PI++Y V+ + + K +W + ++ L Y+ +I A N +G S P
Sbjct: 618 DGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEP 677
Score = 95.5 bits (227), Expect = 2e-18
Identities = 123/581 (21%), Positives = 234/581 (40%), Gaps = 47/581 (8%)
Query: 939 ETEEGKTVILECQT-SHTVSTKWYHNKKEISGMDHREIIQ-EGRXXXXXXXXXXXXDVGV 996
E G++ C S WY+ + E R ++Q EG D G+
Sbjct: 31 ELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGI 90
Query: 997 IKCIVKD-----QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-W- 1049
+C D QE + +L + + + F + E K+ + A + ++S A V W
Sbjct: 91 YRCQATDAKGQTQEATVVLEIYQKLT-FREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWL 149
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES-----CTAEVTVVE 1104
+ E+ N++ +++ I N + DEG Y C R E+ + +V
Sbjct: 150 YHNEEVTTISDNRFAMLANNNLQ---ILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVN 206
Query: 1105 LPPEIITRLQ--NQKVNKGNKATFEIELTKG-DALVRWFKDGSEIQFSNHIQLTIDGKKQ 1161
+PP I + N +G + TF + + + WF++G I+ + + + G
Sbjct: 207 VPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE--KYILKGSNT 264
Query: 1162 KLKIYDCDLDDAGEYSC----EVGNSKCTAILTV-EEPSINFTLRLPEFILVPANTDAYL 1216
+L + + D G Y C + G + A L V +P I ++L N L
Sbjct: 265 ELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHI---IQLKNETTYE-NGQVTL 320
Query: 1217 TVEIPDETL-DVTWYKKKSVIEDTEKFTLIS---DVKKR----TLIIRKCTEDDQCEYTC 1268
+ E + ++TW + TE + +VK + +L I+ D Y C
Sbjct: 321 VCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDC 380
Query: 1269 VLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
+ + + +E+ PK + + Y G+ + + D ++ P + W K+
Sbjct: 381 EAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWR-RDKL 439
Query: 1328 IKKCKHT---KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
+ K+T K + L I + D G Y N+ G E + + D PS P
Sbjct: 440 VLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSP 499
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNI-TKTQTSIQNL 1443
I+E+ ++ + +++P++ G I +Y V+ +E+ + W V++ +T + NL
Sbjct: 500 YGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNL 559
Query: 1444 KTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
+ N++Y R AVN D S+ E ++ + + P++
Sbjct: 560 EPNTTYEIRVAAVNGKGQGDYSK-IEIFQTLPVREPSPPSI 599
Score = 87.8 bits (208), Expect = 4e-16
Identities = 86/343 (25%), Positives = 145/343 (42%), Gaps = 33/343 (9%)
Query: 635 TFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSV 694
TF + Q +G D + CR+ + P P ++WL+ EE+ + A+ ++ +
Sbjct: 116 TFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNN----- 170
Query: 695 LKITNVKKFQEGTYTVVA-VNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGES 751
L+I N+ K EG Y V GE ++ I PP + P KS +GE
Sbjct: 171 LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVI---VNVPPAISMPQKSFNATAERGEE 227
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ S + G+P P I+W +N K ++ +++ ++ D G Y +A N
Sbjct: 228 MTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKA 287
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
G E A + V +P I + + T E G + LV P+P ITW R +
Sbjct: 288 GEDEKQAFLQV------FVQP--HIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVD 339
Query: 872 IISPSETITQNFDGENIELVITNVDSEI--------DSGDYKCVASNSAGKSSHGARVTI 923
+ +E ++ DG IE+ + S + DSG Y C A++ G H + +
Sbjct: 340 GFTFTEG-DKSLDG-RIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG--GHQKSMYL 395
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILEC--QTSHTVSTKWYHNK 964
D+E Q Y + EG + + C +++ S W +K
Sbjct: 396 DIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDK 438
Score = 72.1 bits (169), Expect = 2e-11
Identities = 97/472 (20%), Positives = 182/472 (38%), Gaps = 39/472 (8%)
Query: 736 QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK-----SDGDTHSIT 790
QV L + + GES + +G P +I W N + K + T+ +G +T
Sbjct: 22 QVTISLSKVELSVGESKFFTCTAIGEPE-SIDWY-NPQGEKIISTQRVVVQKEGVRSRLT 79
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
I ++D G+Y +A +++G + + V+ E + F K+
Sbjct: 80 IYNAN-IEDAGIYRCQATDAKGQTQEATVVL------EIYQKLTFREVVSPQEFKQGEDA 132
Query: 851 KLVARVTRNPVPSITW-YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS 909
++V RV+ +P P+++W Y N E+ + S+ N++++ N + D G Y+C
Sbjct: 133 EVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNIN---KSDEGIYRCEGR 189
Query: 910 NSAGKSSHGARVTIDVEKVTFVKHLQKSYET--EEGKTVILECQTSHTV--STKWYHNKK 965
A + + V + QKS+ E G+ + C+ S + + W+ N K
Sbjct: 190 VEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGK 249
Query: 966 EISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRKL 1023
I ++ + I +G D G C ++ E ++ + I +L
Sbjct: 250 LIE--ENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQL 307
Query: 1024 QDFEVKEKDVAILEVEINSETA-DVVWER--DGEIIKPKKNKYD--FEKRGH--IRKLYI 1076
++ E L + E ++ W+R DG D E +G L+I
Sbjct: 308 KNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHI 367
Query: 1077 RNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKG 1133
++ + D G Y C + ++ +E P+ I+ +GN ++
Sbjct: 368 KDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSN 427
Query: 1134 D-ALVRWFKDGSEIQFSNHIQLTI--DGKKQKLKIYDCDLDDAGEYSCEVGN 1182
A + W +D + N L G+K L+I +D G Y+C N
Sbjct: 428 PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
Score = 65.7 bits (153), Expect = 2e-09
Identities = 73/300 (24%), Positives = 119/300 (39%), Gaps = 34/300 (11%)
Query: 628 ILEGIPPTFSKKPKA--QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
++ +PP S K+ + G ++ CR PEP I+W G+ I +EN ++
Sbjct: 203 VIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI--EENEKYILK 260
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+ L + N+ G Y A N+ GE L++ P +I+ LK+
Sbjct: 261 GSN----TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV----QPHIIQ-LKNET 311
Query: 746 VRQGESVILSAQVVGNPRPTITW---------CKNNKPVKA-LPTKSDGDTHSITILKPK 795
+ V L G P P ITW + +K + + K + S+ I K
Sbjct: 312 TYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHI-KDV 370
Query: 796 KVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVAR 855
K+ D G Y +A + G + S + +E P FI+ E I +
Sbjct: 371 KLSDSGRYDCEAASRIGGHQKSMYLDIEYA-------PKFISNQTIYYSWEGNPINISCD 423
Query: 856 VTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV--DSEIDSGDYKCVASNSAG 913
V NP SI W R ++++ P++ T +I + S+ D G Y C A+N G
Sbjct: 424 VKSNPPASIHW-RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
Score = 65.3 bits (152), Expect = 2e-09
Identities = 53/189 (28%), Positives = 83/189 (43%), Gaps = 9/189 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
PS P + E + + + + +P+S+GG PI +Y ++ K V + W KIV G
Sbjct: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW-KIVRSHGVQTMV 554
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIR-MVGSNIVM 1984
+ N++ R++A N G + ++E T+P +P I S
Sbjct: 555 VLNNLEPNTTYEIRVAAVNGKG-----QGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSF 609
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTK-TMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
T + DGGAP+L Y + R K W+E KV N + L Y ++I A
Sbjct: 610 KLSITKQDDGGAPILEYIVKYRSKDKEDQWLE-KKVQGNKDHIILEHLQWTMGYEVQITA 668
Query: 2044 RNEIGLSEP 2052
N +G SEP
Sbjct: 669 ANRLGYSEP 677
Score = 62.9 bits (146), Expect = 1e-08
Identities = 53/286 (18%), Positives = 121/286 (42%), Gaps = 17/286 (5%)
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFK-DGSEIQFSNHIQLTIDGKKQKLKIY 1166
++ L +++ G F + W+ G +I + + + +G + +L IY
Sbjct: 22 QVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIY 81
Query: 1167 DCDLDDAGEYSCEVGNSK-----CTAILTVEEPSINFTLRLPEFILVPANTDAYLTV-EI 1220
+ +++DAG Y C+ ++K T +L + + + P+ + + V
Sbjct: 82 NANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSS 141
Query: 1221 PDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV-LLDAKSTTKL 1279
P + ++ ++ +F ++++ + L I K D+ Y C ++A+
Sbjct: 142 PAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINK---SDEGIYRCEGRVEARGEIDF 198
Query: 1280 K--VEVVEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTK 1335
+ + +V PP I ++ + +RG ++T P+P W N K+I+ ++ K
Sbjct: 199 RDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIE--ENEK 256
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + LT++ + N+D G Y R N G + + + + +P
Sbjct: 257 YILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
Score = 45.6 bits (103), Expect = 0.002
Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 3/67 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + F C+ G P P I+WFR +I ++ + Y + L +R + D G + C
Sbjct: 225 GEEMTFSCRASGSPEPAISWFRNGKLI---EENEKYILKGSNTELTVRNIINSDGGPYVC 281
Query: 584 VAKNAAG 590
A N AG
Sbjct: 282 RATNKAG 288
Score = 35.5 bits (78), Expect = 2.1
Identities = 26/127 (20%), Positives = 43/127 (33%), Gaps = 2/127 (1%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVAT 567
AP F+ ++ +G+ + C V+ P I W R ++ + Y
Sbjct: 400 APKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMI 459
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
L I D G + C A N G L + + P S +G ++
Sbjct: 460 LEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKP 519
Query: 627 DILEGIP 633
D G+P
Sbjct: 520 DSHGGVP 526
>AB209333-1|BAD92570.1| 1560|Homo sapiens protein tyrosine
phosphatase, receptor type, sigma isoform 3 precursor
variant protein.
Length = 1560
Score = 99.1 bits (236), Expect = 2e-19
Identities = 108/530 (20%), Positives = 198/530 (37%), Gaps = 37/530 (6%)
Query: 1473 VIKETKIQS--PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD----GKKLKTAK 1526
V++E ++ S P ++ + E + C G P P++TW++D +
Sbjct: 150 VLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGR 209
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV 1586
Y+C+A N G +S + + + H++
Sbjct: 210 IKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEI 269
Query: 1587 --GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
G +T V G P P V W + L + + + +V+ + ++K S+ YT
Sbjct: 270 MPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPV----GRNVLELTDVK--DSANYT 323
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
A ++ G + V P P P++ E + S+TI W D G + Y +
Sbjct: 324 CVAMSSLGVIEAVAQITVKSLPKAPGTPMV-TENTATSITITW----DSGNPDPVSYYVI 378
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTAL 1764
+++ + D Y I L+ N EY V A N +G + SE +V +T
Sbjct: 379 EYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG--QGPPSESVVTRTGE 436
Query: 1765 DVPSXXXXXXXXXXIDNESVYITW-FPSEKNG--GSPIIDYKVEIKQEGKKWKXXXXXXX 1821
P+ + ++ + W P E NG + Y +E + W+
Sbjct: 437 QAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDS 496
Query: 1822 XXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS 1881
+ L + TY R+ A +G P + D I + P QP N + S
Sbjct: 497 LLTTVGSLLEDETYTVRVLAFTSVGDG-PLS--DPIQVKTQQGVPGQPMNLRAEARSETS 553
Query: 1882 VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRIS 1941
+TL W+ P I Y + F+ +G ++ + +E++K E FR++
Sbjct: 554 ITLSWSPPRQES---IIKYELLFR--EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLA 608
Query: 1942 AENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPE 1991
A + G+ T + + T+ S +++M+ V+ SW P+
Sbjct: 609 ARSPQGLGAFTP-----VVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPD 653
Score = 88.6 bits (210), Expect = 2e-16
Identities = 144/659 (21%), Positives = 253/659 (38%), Gaps = 58/659 (8%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID-SKSA 1343
E PP+ + ++ G + + P+P W K + + D S A
Sbjct: 56 EEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGA 115
Query: 1344 SLTIKKVENT-DAGIYKLRLENNCGHADVEMNVTILDKPS-PPGKPNI--------LEID 1393
L I+ + D +Y+ +N+ G V +T+L + P G PNI +E
Sbjct: 116 VLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERT 175
Query: 1394 SSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWIS-VKNITKTQTSIQNLKTNSSYRF 1451
++ +C +GN I + ++ +D + +K + I++ + ++
Sbjct: 176 RTATMLC----AASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKY 231
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQP 1511
A N + +S Y +V ++ P+ + P ++ +TC+ G P P
Sbjct: 232 ECVATNSAGVRYSSPANLYVRV---RRVAPRFSILPMSH-EIMPGGNVNITCVAVGSPMP 287
Query: 1512 KVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
V W + + L R Y C+A + G +E + ++ P
Sbjct: 288 YVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSAN--YTCVAMSSLGVIEAVAQITVKSLP 345
Query: 1572 VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN-DKEYNITTKEKTSVI 1630
+ + +T + P V +Y K ++ D Y I T+
Sbjct: 346 KAP-GTPMVTENTATS----ITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRY 400
Query: 1631 RIKELKRSHSSKYTIEASNTAGT---SSVEVTLKVYDKPSKPEGPVIMREISRESVTIEW 1687
I L + + + A N+ G S VT P+ V R +S ++ ++W
Sbjct: 401 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 460
Query: 1688 KPPLDDGGL---ELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
+ P++ GL Y +E P N W K +VD + T + L E+ Y RV+A
Sbjct: 461 EEPVEPNGLIRGYRVYYTMEPEHPVGN-WQK-HNVDDSLLT-TVGSLLEDETYTVRVLAF 517
Query: 1745 NPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKV 1804
VG + S+PI +KT VP + S+ ++W P + II Y++
Sbjct: 518 TSVG--DGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPPRQES---IIKYEL 571
Query: 1805 EIKQEGKKWKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKT 1862
+ +EG + ++ L NT Y FR+ AR+ G +T + +T
Sbjct: 572 -LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGA-FTP---VVRQRT 626
Query: 1863 LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK----TVKGKSWTKIVT 1917
L S P+NF V SV L W P+ N SP T Y I++ V G++ K++T
Sbjct: 627 LQSIS-PKNFKVKMIMKTSVLLSWEFPD-NYNSP-TPYKIQYNGLTLDVDGRTTKKLIT 682
Score = 82.6 bits (195), Expect = 1e-14
Identities = 72/264 (27%), Positives = 117/264 (44%), Gaps = 10/264 (3%)
Query: 717 GEASLPIVLKIK-TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
G L +VL + +EPP+ I+ K I G Q G+P+P +TW K K V
Sbjct: 40 GPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKV 99
Query: 776 KALPTKS---DGDTHSITILKPKKV-KDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ ++ D ++ ++P + +DE VY A+NS G A +TV + +
Sbjct: 100 NSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSG 159
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELV 891
P Q V+ T ++ + NP P ITW+++ + PS + + + L
Sbjct: 160 FPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQ 219
Query: 892 ITNVDSEIDSGDYKCVASNSAG-KSSHGARVTIDVEKVT-FVKHLQKSYETEEGKTVILE 949
I + E D G Y+CVA+NSAG + S A + + V +V L S+E G V +
Sbjct: 220 IES-SEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNIT 278
Query: 950 CQT--SHTVSTKWYHNKKEISGMD 971
C S KW ++++ D
Sbjct: 279 CVAVGSPMPYVKWMQGAEDLTPED 302
Score = 81.8 bits (193), Expect = 2e-14
Identities = 82/337 (24%), Positives = 140/337 (41%), Gaps = 34/337 (10%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++ + + G F CQ G P+P++TW ++ + + + +D+ A L
Sbjct: 59 PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 118
Query: 570 IREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I+ + P D + CVA+N+ G E+ V A L+ D
Sbjct: 119 IQPLRTPRDENVYECVAQNSVG------EITVHAKLT-----------------VLREDQ 155
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
L P P+ + V+ + C P+P+I W FK + +P + S +
Sbjct: 156 LPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITW-FK--DFLPVDP-SASNGRIK 211
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREG-EASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ L+I + ++ +G Y VA N G S P L ++ P I P+ I+
Sbjct: 212 QLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIM- 270
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKA 807
G +V ++ VG+P P + W + + + T D +L+ VKD YT A
Sbjct: 271 PGGNVNITCVAVGSPMPYVKWMQGAEDL----TPEDDMPVGRNVLELTDVKDSANYTCVA 326
Query: 808 ENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITV 844
+S G+ E A ITV+ + P + N IT+
Sbjct: 327 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI 363
Score = 80.2 bits (189), Expect = 7e-14
Identities = 75/299 (25%), Positives = 127/299 (42%), Gaps = 23/299 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F K+PK Q G C+ P+P + W KG+++ + IE D
Sbjct: 58 PPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKV--NSQRFETIEFD-ESAG 114
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
+VL+I ++ E Y VA N GE ++ L + ++ P P + + +V +
Sbjct: 115 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 174
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYT 804
+ + GNP P ITW K+ PV P+ S+G + ++ + D+G Y
Sbjct: 175 TRTATMLCAASGNPDPEITWFKDFLPVD--PSASNGRIKQLRSGALQIESSEETDQGKYE 232
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
A NS G+ +S P F + G + + +P+P +
Sbjct: 233 CVATNSAGVRYSSPANLY---VRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYV 289
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W + E ++P + + G N+ L +T+V DS +Y CVA +S G A++T+
Sbjct: 290 KWMQGAEDLTPEDDMPV---GRNV-LELTDVK---DSANYTCVAMSSLGVIEAVAQITV 341
Score = 79.4 bits (187), Expect = 1e-13
Identities = 92/385 (23%), Positives = 148/385 (38%), Gaps = 32/385 (8%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQ 1161
E PP I ++Q G A+F + T GD R W K G ++ + D
Sbjct: 56 EEPPRFIKEPKDQIGVSGGVASFVCQAT-GDPKPRVTWNKKGKKVNSQRFETIEFDESAG 114
Query: 1162 K-LKIYDCDLD-DAGEYSCEVGNS--------KCTAILTVEEPSINFTLRL-PEFILVP- 1209
L+I D Y C NS K T + + PS + + P+ +V
Sbjct: 115 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 174
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
T L + ++TW+K ++ + I ++ L I E DQ +Y CV
Sbjct: 175 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 234
Query: 1270 LLDA-----KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
++ S L V V P+ + I G +V + P P +W+
Sbjct: 235 ATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQG 294
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
++ + P D ++ + D+ Y ++ G + +T+ P P
Sbjct: 295 AEDLT------PEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAP 348
Query: 1385 GKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWISVK-NITKTQTSIQN 1442
G P + E ++SI I WD +GN + YYV+EY+ +K +IT T+ SI
Sbjct: 349 GTPMVTENTATSITITWD----SGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGG 404
Query: 1443 LKTNSSYRFRAYAVNEVDISDASET 1467
L NS Y AVN + SE+
Sbjct: 405 LSPNSEYEIWVSAVNSIGQGPPSES 429
Score = 63.7 bits (148), Expect = 7e-09
Identities = 51/218 (23%), Positives = 101/218 (46%), Gaps = 12/218 (5%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P +V+E+T+ S+T+ W +S P++ Y+IE+K+ K + + + +
Sbjct: 345 PKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKS-KSQDGPYQIKEDITTTRY 400
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMT 1985
I + E +SA N++G P+ES R + A +P ++ RM+ + ++
Sbjct: 401 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRN--VQARMLSATTMIV 458
Query: 1986 SWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN-TLKFNIRDLSENHTYMIRIYAR 2044
W P G + GY + + K +V+ +L + L E+ TY +R+ A
Sbjct: 459 QWEEPVEPNGL-IRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAF 517
Query: 2045 NEIG---LSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
+G LS+P++ + + +PG+ + E +T +
Sbjct: 518 TSVGDGPLSDPIQV-KTQQGVPGQPMNLRAEARSETSI 554
>BC132902-1|AAI32903.1| 354|Homo sapiens myosin binding protein
H-like protein.
Length = 354
Score = 98.3 bits (234), Expect = 3e-19
Identities = 73/317 (23%), Positives = 138/317 (43%), Gaps = 22/317 (6%)
Query: 1273 AKSTTKLKVEVVEFPPKIV---DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIK 1329
A S T + +E PKI + Y K G V LL+ +Q P+P W + +
Sbjct: 36 AGSPTPQLLPPIEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQAIWTHDGCALD 95
Query: 1330 KCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI 1389
+ + + L I++ + D+G Y+LR++ A +++ ++++P PP +
Sbjct: 96 T-RRVSVRNGEQDSILFIREAQRADSGRYQLRVQLGGLEATATIDILVIERPGPPQSIKL 154
Query: 1390 LEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSS 1448
+++ S + W P++TGN+ ++ Y V+ + + W +V ++ +T + +L +S
Sbjct: 155 VDVWGFSATLEWTPPQDTGNTALLGYTVQKADTKSGLWFTVLEHYHRTSCIVSDLIIGNS 214
Query: 1449 YRFRAYAVNEVDISD-ASETTEYYKVIKETKI------------QSPTVEKPLKNITTEP 1495
Y FR +A N+ +S+ A TT+ + K + ++P +PL N TT
Sbjct: 215 YAFRVFAENQCGLSETAPITTDLAHIQKAATVYKTKGFAQRDFSEAPKFTQPLANCTTVT 274
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCI 1551
+ +L C P+PK+ W ++ + K T+ Y C
Sbjct: 275 GYNTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCK 334
Query: 1552 AFNDHGEVETSCVVGIQ 1568
A N GE C V ++
Sbjct: 335 AVNPLGEASVDCRVDVK 351
Score = 80.2 bits (189), Expect = 7e-14
Identities = 47/168 (27%), Positives = 82/168 (48%), Gaps = 5/168 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
KVGD + +G P P+ IW +G L+ + ++ E+ S++ I+E +R+ S +Y
Sbjct: 66 KVGDTVNLLIPFQGKPKPQAIWTHDGCALDT-RRVSVRNGEQDSILFIREAQRADSGRYQ 124
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+ ++ + + V ++P P+ + + ++ S T+EW PP D G L Y ++
Sbjct: 125 LRVQLGGLEATATIDILVIERPGPPQS-IKLVDVWGFSATLEWTPPQDTGNTALLGYTVQ 183
Query: 1705 KHEPDNNRWIKVADVDRDVETYCI-QKLNENCEYMFRVIAQNPVGFSE 1751
K + + W V ++ T CI L Y FRV A+N G SE
Sbjct: 184 KADTKSGLWFTV--LEHYHRTSCIVSDLIIGNSYAFRVFAENQCGLSE 229
Score = 48.8 bits (111), Expect = 2e-04
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 1/97 (1%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F + L T G Q C V PRP+I W + I+ + ++ +
Sbjct: 258 SEAPKFTQPLANCTTVTGYNTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRA-LTHLGIC 316
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+L IR+ P D G +TC A N G AS + V+ P
Sbjct: 317 SLEIRKPGPFDGGIYTCKAVNPLGEASVDCRVDVKVP 353
Score = 45.6 bits (103), Expect = 0.002
Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 11/134 (8%)
Query: 1932 EKDEIIFRISAENTVGVSLPTESQSVRLEKHATV-------PSPPTAPLEIRMVGSNIVM 1984
E+D I+F A+ Q LE AT+ P PP + + + G + +
Sbjct: 105 EQDSILFIREAQRADSGRYQLRVQLGGLEATATIDILVIERPGPPQSIKLVDVWGFSATL 164
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
W P+ G LLGY + D +W V + + + DL ++Y R++A
Sbjct: 165 -EWTPPQDTGNTALLGYTVQKADTKSGLWFTVLE-HYHRTSCIVSDLIIGNSYAFRVFAE 222
Query: 2045 NEIGLSE--PLESD 2056
N+ GLSE P+ +D
Sbjct: 223 NQCGLSETAPITTD 236
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 6/97 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH----S 788
E P+ +PL + G + L V +PRP I W KN ++ P K TH S
Sbjct: 259 EAPKFTQPLANCTTVTGYNTQLFCCVRASPRPKIIWLKNKMDIQGNP-KYRALTHLGICS 317
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+ I KP D G+YT KA N G A + V+ P
Sbjct: 318 LEIRKPGPF-DGGIYTCKAVNPLGEASVDCRVDVKVP 353
Score = 41.5 bits (93), Expect = 0.032
Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 7/104 (6%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE- 1924
P P++ + + S TL+WT P+ G + + Y ++ K W TV H
Sbjct: 146 PGPPQSIKLVDVWGFSATLEWTPPQDTGNTALLGYTVQKADTKSGLW---FTVLEHYHRT 202
Query: 1925 HCI-ENIKEKDEIIFRISAENTVGVS--LPTESQSVRLEKHATV 1965
CI ++ + FR+ AEN G+S P + ++K ATV
Sbjct: 203 SCIVSDLIIGNSYAFRVFAENQCGLSETAPITTDLAHIQKAATV 246
Score = 33.9 bits (74), Expect = 6.4
Identities = 17/67 (25%), Positives = 31/67 (46%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ P P++IW KN ++ + +Y T + I++ YT +A N G +S
Sbjct: 284 VRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCKAVNPLGEAS 343
Query: 1656 VEVTLKV 1662
V+ + V
Sbjct: 344 VDCRVDV 350
>BC132900-1|AAI32901.1| 354|Homo sapiens myosin binding protein
H-like protein.
Length = 354
Score = 98.3 bits (234), Expect = 3e-19
Identities = 73/317 (23%), Positives = 138/317 (43%), Gaps = 22/317 (6%)
Query: 1273 AKSTTKLKVEVVEFPPKIV---DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIK 1329
A S T + +E PKI + Y K G V LL+ +Q P+P W + +
Sbjct: 36 AGSPTPQLLPPIEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQAIWTHDGCALD 95
Query: 1330 KCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI 1389
+ + + L I++ + D+G Y+LR++ A +++ ++++P PP +
Sbjct: 96 T-RRVSVRNGEQDSILFIREAQRADSGRYQLRVQLGGLEATATIDILVIERPGPPQSIKL 154
Query: 1390 LEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSS 1448
+++ S + W P++TGN+ ++ Y V+ + + W +V ++ +T + +L +S
Sbjct: 155 VDVWGFSATLEWTPPQDTGNTALLGYTVQKADTKSGLWFTVLEHYHRTSCIVSDLIIGNS 214
Query: 1449 YRFRAYAVNEVDISD-ASETTEYYKVIKETKI------------QSPTVEKPLKNITTEP 1495
Y FR +A N+ +S+ A TT+ + K + ++P +PL N TT
Sbjct: 215 YAFRVFAENQCGLSETAPITTDLAHIQKAATVYKTKGFAQRDFSEAPKFTQPLANCTTVT 274
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCI 1551
+ +L C P+PK+ W ++ + K T+ Y C
Sbjct: 275 GYNTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCK 334
Query: 1552 AFNDHGEVETSCVVGIQ 1568
A N GE C V ++
Sbjct: 335 AVNPLGEASVDCRVDVK 351
Score = 80.2 bits (189), Expect = 7e-14
Identities = 47/168 (27%), Positives = 82/168 (48%), Gaps = 5/168 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
KVGD + +G P P+ IW +G L+ + ++ E+ S++ I+E +R+ S +Y
Sbjct: 66 KVGDTVNLLIPFQGKPKPQAIWTHDGCALDT-RRVSVRNGEQDSILFIREAQRADSGRYQ 124
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+ ++ + + V ++P P+ + + ++ S T+EW PP D G L Y ++
Sbjct: 125 LRVQLGGLEATATIDILVIERPGPPQS-IKLVDVWGFSATLEWTPPQDTGNTALLGYTVQ 183
Query: 1705 KHEPDNNRWIKVADVDRDVETYCI-QKLNENCEYMFRVIAQNPVGFSE 1751
K + + W V ++ T CI L Y FRV A+N G SE
Sbjct: 184 KADTKSGLWFTV--LEHYHRTSCIVSDLIIGNSYAFRVFAENQCGLSE 229
Score = 48.8 bits (111), Expect = 2e-04
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 1/97 (1%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F + L T G Q C V PRP+I W + I+ + ++ +
Sbjct: 258 SEAPKFTQPLANCTTVTGYNTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRA-LTHLGIC 316
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+L IR+ P D G +TC A N G AS + V+ P
Sbjct: 317 SLEIRKPGPFDGGIYTCKAVNPLGEASVDCRVDVKVP 353
Score = 45.6 bits (103), Expect = 0.002
Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 11/134 (8%)
Query: 1932 EKDEIIFRISAENTVGVSLPTESQSVRLEKHATV-------PSPPTAPLEIRMVGSNIVM 1984
E+D I+F A+ Q LE AT+ P PP + + + G + +
Sbjct: 105 EQDSILFIREAQRADSGRYQLRVQLGGLEATATIDILVIERPGPPQSIKLVDVWGFSATL 164
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
W P+ G LLGY + D +W V + + + DL ++Y R++A
Sbjct: 165 -EWTPPQDTGNTALLGYTVQKADTKSGLWFTVLE-HYHRTSCIVSDLIIGNSYAFRVFAE 222
Query: 2045 NEIGLSE--PLESD 2056
N+ GLSE P+ +D
Sbjct: 223 NQCGLSETAPITTD 236
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 6/97 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH----S 788
E P+ +PL + G + L V +PRP I W KN ++ P K TH S
Sbjct: 259 EAPKFTQPLANCTTVTGYNTQLFCCVRASPRPKIIWLKNKMDIQGNP-KYRALTHLGICS 317
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+ I KP D G+YT KA N G A + V+ P
Sbjct: 318 LEIRKPGPF-DGGIYTCKAVNPLGEASVDCRVDVKVP 353
Score = 41.5 bits (93), Expect = 0.032
Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 7/104 (6%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE- 1924
P P++ + + S TL+WT P+ G + + Y ++ K W TV H
Sbjct: 146 PGPPQSIKLVDVWGFSATLEWTPPQDTGNTALLGYTVQKADTKSGLW---FTVLEHYHRT 202
Query: 1925 HCI-ENIKEKDEIIFRISAENTVGVS--LPTESQSVRLEKHATV 1965
CI ++ + FR+ AEN G+S P + ++K ATV
Sbjct: 203 SCIVSDLIIGNSYAFRVFAENQCGLSETAPITTDLAHIQKAATV 246
Score = 33.9 bits (74), Expect = 6.4
Identities = 17/67 (25%), Positives = 31/67 (46%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ P P++IW KN ++ + +Y T + I++ YT +A N G +S
Sbjct: 284 VRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCKAVNPLGEAS 343
Query: 1656 VEVTLKV 1662
V+ + V
Sbjct: 344 VDCRVDV 350
>U75330-1|AAB80803.1| 837|Homo sapiens neural cell adhesion protein
protein.
Length = 837
Score = 97.9 bits (233), Expect = 3e-19
Identities = 138/660 (20%), Positives = 256/660 (38%), Gaps = 45/660 (6%)
Query: 1215 YLTVEIPDETLDVTWYKKKSV-IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA 1273
+ T E + WY + I T++ + + L I +D Y C DA
Sbjct: 39 FFTCTAIGEPRSIDWYNPQGEKIISTQRVVVQKGGVRSRLTIYNANIEDAGIYRCQATDA 98
Query: 1274 KSTTKLKVEVVEFPPKIVDYE--REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKC 1331
K T+ V+E K+ E K+G D ++ + P P W+ +++ +
Sbjct: 99 KGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTI 158
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKL--RLENNCGHADVEMNVTILDKPSPPGKP-- 1387
+ ++ + + +L I + +D GIY+ R+E G D + I++ P P
Sbjct: 159 SDNRLAMLANN-NLQILNINKSDEGIYRCEGRVEAR-GEIDFRDIIVIVNVPPAISMPQK 216
Query: 1388 NILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNS 1447
+ + + + I + + I+ E +K + T+ +++N+ +
Sbjct: 217 SFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG-SNTELTVRNIINSD 275
Query: 1448 SYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGG 1507
+ A N+ + E + +V +Q ++ LKN TT N + L C G
Sbjct: 276 GGPYVCRATNK---AGEDEKQAFLQVF----VQPHIIQ--LKNETTYENGQVTLVCDAEG 326
Query: 1508 VPQPKVTWYR--------DGKKLKTAKATYENRXXXXXXXXXX---XXXXXYKCIAFNDH 1556
P P++TW R +G K + + + Y C A +
Sbjct: 327 EPIPEITWKRAVDGFTFTEGDKSPDGRIEVKGQHGSSSLHIKDVKLSGSGRYDCEAASRI 386
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
G + S + I+ P ISN+ I + G+ ++ ++ PP + W ++ L
Sbjct: 387 GGHQKSMYLDIEYAPKF-ISNQTIYYSWE-GNPINISCDVKSNPPASIHWRRDKLVLPAK 444
Query: 1617 KEYNITTKE--KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVI 1674
N+ T + ++ I + +Y A+N GT E L + D PS P G I
Sbjct: 445 NTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKI 504
Query: 1675 MREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCI-QKLNE 1733
+ E+S+ + + + P GG+ + Y ++ E + W V V+T + L
Sbjct: 505 I-ELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVR--SHGVQTMVVLNNLEP 561
Query: 1734 NCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEK 1793
N Y RV A N G + + E I + PS + + IT +
Sbjct: 562 NTTYEIRVAAVNGKGQGDYSKIE-IFQTLPVREPSPPSIHGQPSSGKSFKLSIT---KQD 617
Query: 1794 NGGSPIIDYKVEIKQEGK--KW-KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+GG+PI++Y V+ + + K +W + ++ L +FR+ A N +G S P
Sbjct: 618 DGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGMKFRLPAANRLGYSEP 677
Score = 88.6 bits (210), Expect = 2e-16
Identities = 116/562 (20%), Positives = 224/562 (39%), Gaps = 46/562 (8%)
Query: 957 STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXX-DVGVIKCIVKD-----QETSTML 1010
S WY+ + E R ++Q+G D G+ +C D QE + +L
Sbjct: 50 SIDWYNPQGEKIISTQRVVVQKGGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVL 109
Query: 1011 VVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-W-ERDGEIIKPKKNKYDFEKR 1068
+ + + F + E K+ + A + ++S A V W + E+ N+
Sbjct: 110 EIYQKLT-FREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRLAMLAN 168
Query: 1069 GHIRKLYIRNTSVHDEGEYSCILRDES-----CTAEVTVVELPPEIITRLQ--NQKVNKG 1121
+++ I N + DEG Y C R E+ + +V +PP I + N +G
Sbjct: 169 NNLQ---ILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERG 225
Query: 1122 NKATFEIELTKG-DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC-- 1178
+ TF + + + WF++G I+ + + + G +L + + D G Y C
Sbjct: 226 EEMTFSCRASGSPEPAISWFRNGKLIEENE--KYILKGSNTELTVRNIINSDGGPYVCRA 283
Query: 1179 --EVGNSKCTAILTV-EEPSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTWYKKKS 1234
+ G + A L V +P I ++L N L + E + ++TW +
Sbjct: 284 TNKAGEDEKQAFLQVFVQPHI---IQLKNETTYE-NGQVTLVCDAEGEPIPEITWKRAVD 339
Query: 1235 VIEDTE-------KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEF 1286
TE + + +L I+ Y C + + + +E+
Sbjct: 340 GFTFTEGDKSPDGRIEVKGQHGSSSLHIKDVKLSGSGRYDCEAASRIGGHQKSMYLDIEY 399
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT---KPSIDSKSA 1343
PK + + Y G+ + + D ++ P + W K++ K+T K +
Sbjct: 400 APKFISNQTIYYSWEGNPINISCDVKSNPPASIHWR-RDKLVLPAKNTTNLKTYSTGRKM 458
Query: 1344 SLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDE 1403
L I + D G Y N+ G E + + D PS P I+E+ ++ + +++
Sbjct: 459 ILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNK 518
Query: 1404 PENTGNSTIIYYVVEYQEIDTTEWISVKNI-TKTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
P++ G I +Y V+ +E+ + W V++ +T + NL+ N++Y R AVN
Sbjct: 519 PDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQG 578
Query: 1463 DASETTEYYKVIKETKIQSPTV 1484
D S+ E ++ + + P++
Sbjct: 579 DYSK-IEIFQTLPVREPSPPSI 599
Score = 85.4 bits (202), Expect = 2e-15
Identities = 85/342 (24%), Positives = 140/342 (40%), Gaps = 31/342 (9%)
Query: 635 TFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSV 694
TF + Q +G D + CR+ + P P ++WL+ EE+ + +A+ ++ +
Sbjct: 116 TFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRLAMLANNN----- 170
Query: 695 LKITNVKKFQEGTYTVVA-VNREGEASLPIVLKIKTGEKEPPQVIEPLKSM--IVRQGES 751
L+I N+ K EG Y V GE ++ I PP + P KS +GE
Sbjct: 171 LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVI---VNVPPAISMPQKSFNATAERGEE 227
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
+ S + G+P P I+W +N K ++ +++ ++ D G Y +A N
Sbjct: 228 MTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKA 287
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
G E A + V +P I + + T E G + LV P+P ITW R +
Sbjct: 288 GEDEKQAFLQV------FVQP--HIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVD 339
Query: 872 II-------SPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
SP I + L I +V SG Y C A++ G H + +D
Sbjct: 340 GFTFTEGDKSPDGRIEVKGQHGSSSLHIKDVKLS-GSGRYDCEAASRIG--GHQKSMYLD 396
Query: 925 VEKVTFVKHLQKSYETEEGKTVILEC--QTSHTVSTKWYHNK 964
+E Q Y + EG + + C +++ S W +K
Sbjct: 397 IEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDK 438
Score = 72.5 bits (170), Expect = 1e-11
Identities = 95/471 (20%), Positives = 182/471 (38%), Gaps = 37/471 (7%)
Query: 736 QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK----SDGDTHSITI 791
QV L + + GES + +G PR +I W N + K + T+ G S
Sbjct: 22 QVTISLSKVELSVGESKFFTCTAIGEPR-SIDWY-NPQGEKIISTQRVVVQKGGVRSRLT 79
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIK 851
+ ++D G+Y +A +++G + + V+ E + F K+ +
Sbjct: 80 IYNANIEDAGIYRCQATDAKGQTQEATVVL------EIYQKLTFREVVSPQEFKQGEDAE 133
Query: 852 LVARVTRNPVPSITW-YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
+V RV+ +P P+++W Y N E+ + S+ N++++ N + D G Y+C
Sbjct: 134 VVCRVSSSPAPAVSWLYHNEEVTTISDNRLAMLANNNLQILNIN---KSDEGIYRCEGRV 190
Query: 911 SAGKSSHGARVTIDVEKVTFVKHLQKSYET--EEGKTVILECQTSHTV--STKWYHNKKE 966
A + + V + QKS+ E G+ + C+ S + + W+ N K
Sbjct: 191 EARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKL 250
Query: 967 ISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRKLQ 1024
I ++ + I +G D G C ++ E ++ + I +L+
Sbjct: 251 IE--ENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLK 308
Query: 1025 DFEVKEKDVAILEVEINSETA-DVVWER--DG----EIIKPKKNKYDFEKRGHIRKLYIR 1077
+ E L + E ++ W+R DG E K + + + + L+I+
Sbjct: 309 NETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSPDGRIEVKGQHGSSSLHIK 368
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGD 1134
+ + G Y C + ++ +E P+ I+ +GN ++
Sbjct: 369 DVKLSGSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNP 428
Query: 1135 -ALVRWFKDGSEIQFSNHIQLTI--DGKKQKLKIYDCDLDDAGEYSCEVGN 1182
A + W +D + N L G+K L+I +D G Y+C N
Sbjct: 429 PASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
Score = 64.9 bits (151), Expect = 3e-09
Identities = 72/300 (24%), Positives = 117/300 (39%), Gaps = 34/300 (11%)
Query: 628 ILEGIPPTFSKKPKA--QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
++ +PP S K+ + G ++ CR PEP I+W G+ I +EN ++
Sbjct: 203 VIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLI--EENEKYILK 260
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+ L + N+ G Y A N+ GE L++ P +I+ LK+
Sbjct: 261 GSN----TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV----QPHIIQ-LKNET 311
Query: 746 VRQGESVILSAQVVGNPRPTITWCK----------NNKPVKALPTKSDGDTHSITILKPK 795
+ V L G P P ITW + + P + K + S+ I K
Sbjct: 312 TYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSPDGRIEVKGQHGSSSLHI-KDV 370
Query: 796 KVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVAR 855
K+ G Y +A + G + S + +E P FI+ E I +
Sbjct: 371 KLSGSGRYDCEAASRIGGHQKSMYLDIEYA-------PKFISNQTIYYSWEGNPINISCD 423
Query: 856 VTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNV--DSEIDSGDYKCVASNSAG 913
V NP SI W R ++++ P++ T +I + S+ D G Y C A+N G
Sbjct: 424 VKSNPPASIHW-RRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIG 482
Score = 61.7 bits (143), Expect = 3e-08
Identities = 52/189 (27%), Positives = 81/189 (42%), Gaps = 9/189 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
PS P + E + + + + +P+S+GG PI +Y ++ K V + W KIV G
Sbjct: 496 PSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIW-KIVRSHGVQTMV 554
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIR-MVGSNIVM 1984
+ N++ R++A N G + ++E T+P +P I S
Sbjct: 555 VLNNLEPNTTYEIRVAAVNGKG-----QGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSF 609
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTK-TMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
T + DGGAP+L Y + R K W+E KV N + L R+ A
Sbjct: 610 KLSITKQDDGGAPILEYIVKYRSKDKEDQWLE-KKVQGNKDHIILEHLQWTMGMKFRLPA 668
Query: 2044 RNEIGLSEP 2052
N +G SEP
Sbjct: 669 ANRLGYSEP 677
Score = 59.7 bits (138), Expect = 1e-07
Identities = 57/288 (19%), Positives = 120/288 (41%), Gaps = 21/288 (7%)
Query: 1108 EIITRLQNQKVNKGNKATFEIELTKGDALVRWFK-DGSEIQFSNHIQLTIDGKKQKLKIY 1166
++ L +++ G F + W+ G +I + + + G + +L IY
Sbjct: 22 QVTISLSKVELSVGESKFFTCTAIGEPRSIDWYNPQGEKIISTQRVVVQKGGVRSRLTIY 81
Query: 1167 DCDLDDAGEYSCEVGNSK-----CTAILTV-EEPSINFTLRLPEFILVPANTDAYLTVEI 1220
+ +++DAG Y C+ ++K T +L + ++ + + EF DA + +
Sbjct: 82 NANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEF---KQGEDAEVVCRV 138
Query: 1221 PDETLD-VTW-YKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV-LLDAKSTT 1277
V+W Y + V T ++ + L I + D+ Y C ++A+
Sbjct: 139 SSSPAPAVSWLYHNEEV--TTISDNRLAMLANNNLQILNINKSDEGIYRCEGRVEARGEI 196
Query: 1278 KLK--VEVVEFPPKIVDYEREYR--IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH 1333
+ + +V PP I ++ + +RG ++T P+P W N K+I+ ++
Sbjct: 197 DFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIE--EN 254
Query: 1334 TKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
K + + LT++ + N+D G Y R N G + + + + +P
Sbjct: 255 EKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 302
Score = 45.6 bits (103), Expect = 0.002
Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 3/67 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + F C+ G P P I+WFR +I ++ + Y + L +R + D G + C
Sbjct: 225 GEEMTFSCRASGSPEPAISWFRNGKLI---EENEKYILKGSNTELTVRNIINSDGGPYVC 281
Query: 584 VAKNAAG 590
A N AG
Sbjct: 282 RATNKAG 288
Score = 35.5 bits (78), Expect = 2.1
Identities = 26/127 (20%), Positives = 43/127 (33%), Gaps = 2/127 (1%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQM-YYDDDNVAT 567
AP F+ ++ +G+ + C V+ P I W R ++ + Y
Sbjct: 400 APKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMI 459
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAPLSDHGSEMTVXXXXXXXXXXXXA 626
L I D G + C A N G L + + P S +G ++
Sbjct: 460 LEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKP 519
Query: 627 DILEGIP 633
D G+P
Sbjct: 520 DSHGGVP 526
>S71824-1|AAB31836.1| 848|Homo sapiens N-CAM protein.
Length = 848
Score = 97.9 bits (233), Expect = 3e-19
Identities = 140/691 (20%), Positives = 269/691 (38%), Gaps = 60/691 (8%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTI---D 1157
T V L +I+ V + ++ D + WF E N ++++ D
Sbjct: 16 TAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWND 75
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEV---GNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
L IY+ ++DDAG Y C V S+ A + V+ P DA
Sbjct: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
Query: 1215 YLTVEIPDETLDVTWYKKKS---VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC--- 1268
+ ++ +K K +++ +F ++S+ L IR + D+ Y C
Sbjct: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGR 192
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYER--EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
+L + K +V PP I + G VTL+ D + FP+P W + +
Sbjct: 193 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252
Query: 1327 IIKKCKHTKPSIDSKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
I++ + + I S +S LTIKKV+ D Y EN G D +++ + KP
Sbjct: 253 QIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY 312
Query: 1386 KPN--ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQ- 1441
N +E++ C E +G+ I + W S +NI+ + ++
Sbjct: 313 VENQTAMELEEQVTLTC----EASGD-----------PIPSITWRTSTRNISSEEKTLDG 357
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASE--TTEYYKVIKET-----KIQ-SPTVEKPLKNITT 1493
++ S R + + + +DA E T + +++ ++Q +P ++ P+ T
Sbjct: 358 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW 417
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT----YENRXXXXXXXX--XXXXXXX 1547
E N+ + +TC P ++W+RDG+ L ++ + Y
Sbjct: 418 EGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 476
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGD-EWLVTAVIEGIP--PPEV 1604
Y C A N G+ ++ +Q + S + ++ ++ G+P +
Sbjct: 477 YNCTAVNRIGQESLEFIL-VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKA 535
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD 1664
W G ++ + K Y+ ++ I LK + + A N G + +
Sbjct: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595
Query: 1665 KP--SKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
+P +P P + ++ + +I+ DDGG + Y + ++ ++ W +
Sbjct: 596 QPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV-RYRALSSEWKPEIRLPS 654
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
+ ++ L+ N EY V+A+N G S+A
Sbjct: 655 GSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 685
Score = 89.8 bits (213), Expect = 9e-17
Identities = 130/655 (19%), Positives = 241/655 (36%), Gaps = 54/655 (8%)
Query: 1226 DVTWYKK--KSVIEDTEKFTLI-SDVKKRTLIIRKCTEDDQCEYTCVLL-DAKSTTKLKV 1281
D++W+ + + + ++ +++ +D TL I DD Y CV+ + S ++ V
Sbjct: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
Query: 1282 EVVEFPPKIV-DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V F + + + G D ++ D + P W + + K + + S
Sbjct: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
Query: 1341 KSASLTIKKVENTDAGIYK----LRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSS- 1395
+ L I+ ++ TD G Y+ + D+++ V + P+ + NI+ ++
Sbjct: 171 NNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV--PPTIQARQNIVNATANL 227
Query: 1396 --SINICWDE---PENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
S+ + D PE T + T +E QE D ++I + +Q +I+ + N
Sbjct: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIE-QEEDDEKYIFSDD--SSQLTIKKVDKNDEAE 284
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ A N+ DA+ + + K T +++ T E E + LTC G P
Sbjct: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTA--------MELEEQVTLTCEASGDPI 336
Query: 1511 PKVTWYRDGKKLKTAKATYENR---------XXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
P +TW + + + + T + Y C A N G+
Sbjct: 337 PSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQ 396
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
S + +Q P + + G++ +T + P + W+++G L + NI
Sbjct: 397 SMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 453
Query: 1622 T--TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREIS 1679
S + + + Y A N G S+E L D PS P + E
Sbjct: 454 KIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPY 511
Query: 1680 RESVTIEWKPPLDDGGLELTKYAIE----KHEPDNNRWIKVADVDRDVETYCIQKLNENC 1735
+ +++ P GG+ + KY E E +++W + + I L
Sbjct: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME-GIVTIVGLKPET 570
Query: 1736 EYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNG 1795
Y R+ A N G E + + PS D S+ + + +G
Sbjct: 571 TYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVNLI-KQDDG 628
Query: 1796 GSPIIDYKVEIKQEGKKWK--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGTS 1848
GSPI Y V + +WK ++ L N Y+ + A N+ G S
Sbjct: 629 GSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683
Score = 89.0 bits (211), Expect = 2e-16
Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 36/398 (9%)
Query: 593 SSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDIL 652
SS+T I A + D G V ++ F P Q EG D +
Sbjct: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
+ C +V+ P I W KG +++ +++ + S+ + L+I +KK EGTY
Sbjct: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-----NYLQIRGIKKTDEGTYRCEG 191
Query: 713 -VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKN 771
+ GE + + ++ Q + + + G+SV L G P PT++W K+
Sbjct: 192 RILARGEINFKDI-QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
Query: 772 NKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
+ ++ D+ +TI K K DE Y AEN G E A I + +
Sbjct: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDK-NDEAEYICIAENKAG--EQDATIHL----K 303
Query: 828 ENAEPPL-FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGE 886
A+P + ++ + ++E+ + L + +P+PSITW + IS E + DG
Sbjct: 304 VFAKPKITYVENQTAMELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEE---KTLDGH 358
Query: 887 NIELVITNVDS-------EIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
+ V S D+G+Y C ASN+ G+ S + ++V+ ++ Y
Sbjct: 359 MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS--MYLEVQYAPKLQGPVAVY- 415
Query: 940 TEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREI 975
T EG V + C+ + + W+ + + + ++ I
Sbjct: 416 TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 453
Score = 85.4 bits (202), Expect = 2e-15
Identities = 74/299 (24%), Positives = 126/299 (42%), Gaps = 25/299 (8%)
Query: 628 ILEGIPPTFSKKPKA--QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
++ +PPT + + G + L C PEP ++W GE+I +E+ I
Sbjct: 206 VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF 265
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
SD S L I V K E Y +A N+ GE I LK+ P++
Sbjct: 266 SDDS---SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA----KPKITYVENQTA 318
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGD----TH---SITILKPKKVK 798
+ E V L+ + G+P P+ITW + + + + DG +H S LK +
Sbjct: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
D G Y A N+ I + S + +E + P+ + + E + + V
Sbjct: 379 DAGEYICTASNT--IGQDSQSMYLEVQYAPKLQGPVAVYTW------EGNQVNITCEVFA 430
Query: 859 NPVPSITWYRNNEIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P +I+W+R+ +++ S + + ++ + + DSE D G+Y C A N G+ S
Sbjct: 431 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
Score = 73.7 bits (173), Expect = 6e-12
Identities = 112/536 (20%), Positives = 218/536 (40%), Gaps = 51/536 (9%)
Query: 1025 DFEVKEKDVAILEVEINSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRK-LYIRNTSVH 1082
+ V E + +V +++ D+ W +GE + P + + L I N ++
Sbjct: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
Query: 1083 DEGEYSCILRDESCT-AEVTV-VELPPEIITRLQN--QKVNKGNKATFEIELTKG-DALV 1137
D G Y C++ E + +E TV V++ +++ + Q+ +G A ++ +
Sbjct: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTI 149
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-------NSKCTAILT 1190
W G ++ ++ + L+I D G Y CE N K ++
Sbjct: 150 IWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIV 208
Query: 1191 VEEPSI-------NFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE---DTE 1240
P+I N T L + + + + + + P+ T+ +W K IE D E
Sbjct: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGF-----PEPTM--SWTKDGEQIEQEEDDE 261
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYEREYRI 1299
K+ D + T I+K ++D+ EY C+ + + + F PKI E + +
Sbjct: 262 KYIFSDDSSQLT--IKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK-----HTKPSIDSKSASLTIKKVENTD 1354
+ VTL + P P+ W +++ I + H ++ +SLT+K ++ TD
Sbjct: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
AG Y N G M + + P G + + + +NI E ++TI +
Sbjct: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITC-EVFAYPSATISW 438
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI 1474
+ + Q + ++ + ++K S + +S F Y V+ E+ E+ V
Sbjct: 439 F-RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN-RIGQESLEFILVQ 496
Query: 1475 KETKIQSPTVE--KPLKNITTEPNEDIELTCIFGGVP--QPKVTWYRDGKKLKTAK 1526
+T SP+++ +P + ++ E T GGVP + K W G+++ +K
Sbjct: 497 ADTP-SSPSIDQVEPYSSTAQVQFDEPEAT---GGVPILKYKAEWRAVGEEVWHSK 548
Score = 54.4 bits (125), Expect = 4e-06
Identities = 25/79 (31%), Positives = 41/79 (51%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G +V C EG+P P ++W + I+ +D + Y D+ + L I++V D + C
Sbjct: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N AG +T L V A
Sbjct: 288 IAENKAGEQDATIHLKVFA 306
Score = 48.0 bits (109), Expect = 4e-04
Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P A Y EG+ + + C + A P I+W F+ +++P N S I+ S L++T
Sbjct: 411 PVAVYTWEGNQVNITCEVFAYPSATISW-FRDGQLLPSSNYS-NIKIYNTPSASYLEVTP 468
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKS 743
+ G Y AVNR G+ SL +L ++ P + +EP S
Sbjct: 469 DSENDFGNYNCTAVNRIGQESLEFIL-VQADTPSSPSIDQVEPYSS 513
Score = 45.6 bits (103), Expect = 0.002
Identities = 44/189 (23%), Positives = 85/189 (44%), Gaps = 7/189 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSW-TKIVTVGGSVHE 1924
PS P V E S + +++ EPE+ GG PI Y E++ V + W +K + E
Sbjct: 500 PSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 558
Query: 1925 HCIENIKEKDEIIF--RISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNI 1982
+ + K E + R++A N G+ + + + + PS P ++ G++I
Sbjct: 559 GIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSI 618
Query: 1983 VMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+ + DGG+P+ Y + R ++ + W ++ + ++ L N Y + +
Sbjct: 619 KVNL--IKQDDGGSPIRHYLVRYRALS-SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 675
Query: 2043 ARNEIGLSE 2051
A N+ G S+
Sbjct: 676 AENQQGKSK 684
Score = 41.1 bits (92), Expect = 0.042
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 4/85 (4%)
Query: 520 HTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQ--MYYDDDNVATLVIREVFPED 577
+T +G+ V C+V YP I+WFR ++ PS ++ Y+ + + L + D
Sbjct: 415 YTWEGNQVNITCEVFAYPSATISWFRDGQLL-PSSNYSNIKIYNTPSASYLEVTPDSEND 473
Query: 578 AGTFTCVAKNAAGFASSTTELIVEA 602
G + C A N G S ++V+A
Sbjct: 474 FGNYNCTAVNRIG-QESLEFILVQA 497
Score = 40.7 bits (91), Expect = 0.056
Identities = 33/131 (25%), Positives = 53/131 (40%), Gaps = 3/131 (2%)
Query: 524 GSTVQFECQVEGYPRPQ-ITWFRQTAI-IKPSQD-FQMYYDDDNVATLVIREVFPEDAGT 580
G + F CQV G + + I+WF + P+Q + ++DD+ +TL I +DAG
Sbjct: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
Query: 581 FTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKP 640
+ CV G S T + + T D++ +PPT K
Sbjct: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Query: 641 KAQYVDEGSDI 651
K + V D+
Sbjct: 154 KGRDVILKKDV 164
Score = 36.7 bits (81), Expect = 0.91
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 4/79 (5%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQ---DFQMYYDDD-NVATLVIREVFPEDAGTFT 582
V C+ G P P ITW T I + D M V++L ++ + DAG +
Sbjct: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
Query: 583 CVAKNAAGFASSTTELIVE 601
C A N G S + L V+
Sbjct: 385 CTASNTIGQDSQSMYLEVQ 403
>AB209443-1|BAD92680.1| 807|Homo sapiens Neural cell adhesion
molecule 1, 120 kDa isoform precursor variant protein.
Length = 807
Score = 97.9 bits (233), Expect = 3e-19
Identities = 140/691 (20%), Positives = 269/691 (38%), Gaps = 60/691 (8%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTI---D 1157
T V L +I+ V + ++ D + WF E N ++++ D
Sbjct: 97 TAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWND 156
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEV---GNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
L IY+ ++DDAG Y C V S+ A + V+ P DA
Sbjct: 157 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 216
Query: 1215 YLTVEIPDETLDVTWYKKKS---VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC--- 1268
+ ++ +K K +++ +F ++S+ L IR + D+ Y C
Sbjct: 217 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGR 273
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYER--EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
+L + K +V PP I + G VTL+ D + FP+P W + +
Sbjct: 274 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 333
Query: 1327 IIKKCKHTKPSIDSKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
I++ + + I S +S LTIKKV+ D Y EN G D +++ + KP
Sbjct: 334 QIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY 393
Query: 1386 KPN--ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQ- 1441
N +E++ C E +G+ I + W S +NI+ + ++
Sbjct: 394 VENQTAMELEEQVTLTC----EASGD-----------PIPSITWRTSTRNISSEEKTLDG 438
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASE--TTEYYKVIKET-----KIQ-SPTVEKPLKNITT 1493
++ S R + + + +DA E T + +++ ++Q +P ++ P+ T
Sbjct: 439 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW 498
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT----YENRXXXXXXXX--XXXXXXX 1547
E N+ + +TC P ++W+RDG+ L ++ + Y
Sbjct: 499 EGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 557
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGD-EWLVTAVIEGIP--PPEV 1604
Y C A N G+ ++ +Q + S + ++ ++ G+P +
Sbjct: 558 YNCTAVNRIGQESLEFIL-VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKA 616
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD 1664
W G ++ + K Y+ ++ I LK + + A N G + +
Sbjct: 617 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 676
Query: 1665 KP--SKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
+P +P P + ++ + +I+ DDGG + Y + ++ ++ W +
Sbjct: 677 QPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV-RYRALSSEWKPEIRLPS 735
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
+ ++ L+ N EY V+A+N G S+A
Sbjct: 736 GSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 766
Score = 89.8 bits (213), Expect = 9e-17
Identities = 130/655 (19%), Positives = 241/655 (36%), Gaps = 54/655 (8%)
Query: 1226 DVTWYKK--KSVIEDTEKFTLI-SDVKKRTLIIRKCTEDDQCEYTCVLL-DAKSTTKLKV 1281
D++W+ + + + ++ +++ +D TL I DD Y CV+ + S ++ V
Sbjct: 132 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 191
Query: 1282 EVVEFPPKIV-DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V F + + + G D ++ D + P W + + K + + S
Sbjct: 192 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 251
Query: 1341 KSASLTIKKVENTDAGIYK----LRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSS- 1395
+ L I+ ++ TD G Y+ + D+++ V + P+ + NI+ ++
Sbjct: 252 NNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV--PPTIQARQNIVNATANL 308
Query: 1396 --SINICWDE---PENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
S+ + D PE T + T +E QE D ++I + +Q +I+ + N
Sbjct: 309 GQSVTLVCDAEGFPEPTMSWTKDGEQIE-QEEDDEKYIFSDD--SSQLTIKKVDKNDEAE 365
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ A N+ DA+ + + K T +++ T E E + LTC G P
Sbjct: 366 YICIAENKAGEQDATIHLKVFAKPKITYVENQTA--------MELEEQVTLTCEASGDPI 417
Query: 1511 PKVTWYRDGKKLKTAKATYENR---------XXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
P +TW + + + + T + Y C A N G+
Sbjct: 418 PSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQ 477
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
S + +Q P + + G++ +T + P + W+++G L + NI
Sbjct: 478 SMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 534
Query: 1622 T--TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREIS 1679
S + + + Y A N G S+E L D PS P + E
Sbjct: 535 KIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPY 592
Query: 1680 RESVTIEWKPPLDDGGLELTKYAIE----KHEPDNNRWIKVADVDRDVETYCIQKLNENC 1735
+ +++ P GG+ + KY E E +++W + + I L
Sbjct: 593 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME-GIVTIVGLKPET 651
Query: 1736 EYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNG 1795
Y R+ A N G E + + PS D S+ + + +G
Sbjct: 652 TYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVNLI-KQDDG 709
Query: 1796 GSPIIDYKVEIKQEGKKWK--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGTS 1848
GSPI Y V + +WK ++ L N Y+ + A N+ G S
Sbjct: 710 GSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 764
Score = 89.0 bits (211), Expect = 2e-16
Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 36/398 (9%)
Query: 593 SSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDIL 652
SS+T I A + D G V ++ F P Q EG D +
Sbjct: 158 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 217
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
+ C +V+ P I W KG +++ +++ + S+ + L+I +KK EGTY
Sbjct: 218 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-----NYLQIRGIKKTDEGTYRCEG 272
Query: 713 -VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKN 771
+ GE + + ++ Q + + + G+SV L G P PT++W K+
Sbjct: 273 RILARGEINFKDI-QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 331
Query: 772 NKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
+ ++ D+ +TI K K DE Y AEN G E A I + +
Sbjct: 332 GEQIEQEEDDEKYIFSDDSSQLTIKKVDK-NDEAEYICIAENKAG--EQDATIHL----K 384
Query: 828 ENAEPPL-FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGE 886
A+P + ++ + ++E+ + L + +P+PSITW + IS E + DG
Sbjct: 385 VFAKPKITYVENQTAMELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEE---KTLDGH 439
Query: 887 NIELVITNVDS-------EIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
+ V S D+G+Y C ASN+ G+ S + ++V+ ++ Y
Sbjct: 440 MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS--MYLEVQYAPKLQGPVAVY- 496
Query: 940 TEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREI 975
T EG V + C+ + + W+ + + + ++ I
Sbjct: 497 TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 534
Score = 85.4 bits (202), Expect = 2e-15
Identities = 74/299 (24%), Positives = 126/299 (42%), Gaps = 25/299 (8%)
Query: 628 ILEGIPPTFSKKPKA--QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
++ +PPT + + G + L C PEP ++W GE+I +E+ I
Sbjct: 287 VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF 346
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
SD S L I V K E Y +A N+ GE I LK+ P++
Sbjct: 347 SDDS---SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA----KPKITYVENQTA 399
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGD----TH---SITILKPKKVK 798
+ E V L+ + G+P P+ITW + + + + DG +H S LK +
Sbjct: 400 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 459
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
D G Y A N+ I + S + +E + P+ + + E + + V
Sbjct: 460 DAGEYICTASNT--IGQDSQSMYLEVQYAPKLQGPVAVYTW------EGNQVNITCEVFA 511
Query: 859 NPVPSITWYRNNEIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P +I+W+R+ +++ S + + ++ + + DSE D G+Y C A N G+ S
Sbjct: 512 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 570
Score = 73.7 bits (173), Expect = 6e-12
Identities = 112/536 (20%), Positives = 218/536 (40%), Gaps = 51/536 (9%)
Query: 1025 DFEVKEKDVAILEVEINSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRK-LYIRNTSVH 1082
+ V E + +V +++ D+ W +GE + P + + L I N ++
Sbjct: 111 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 170
Query: 1083 DEGEYSCILRDESCT-AEVTV-VELPPEIITRLQN--QKVNKGNKATFEIELTKG-DALV 1137
D G Y C++ E + +E TV V++ +++ + Q+ +G A ++ +
Sbjct: 171 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTI 230
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-------NSKCTAILT 1190
W G ++ ++ + L+I D G Y CE N K ++
Sbjct: 231 IWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIV 289
Query: 1191 VEEPSI-------NFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE---DTE 1240
P+I N T L + + + + + + P+ T+ +W K IE D E
Sbjct: 290 NVPPTIQARQNIVNATANLGQSVTLVCDAEGF-----PEPTM--SWTKDGEQIEQEEDDE 342
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYEREYRI 1299
K+ D + T I+K ++D+ EY C+ + + + F PKI E + +
Sbjct: 343 KYIFSDDSSQLT--IKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 400
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK-----HTKPSIDSKSASLTIKKVENTD 1354
+ VTL + P P+ W +++ I + H ++ +SLT+K ++ TD
Sbjct: 401 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 460
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
AG Y N G M + + P G + + + +NI E ++TI +
Sbjct: 461 AGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITC-EVFAYPSATISW 519
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI 1474
+ + Q + ++ + ++K S + +S F Y V+ E+ E+ V
Sbjct: 520 F-RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN-RIGQESLEFILVQ 577
Query: 1475 KETKIQSPTVE--KPLKNITTEPNEDIELTCIFGGVP--QPKVTWYRDGKKLKTAK 1526
+T SP+++ +P + ++ E T GGVP + K W G+++ +K
Sbjct: 578 ADTP-SSPSIDQVEPYSSTAQVQFDEPEAT---GGVPILKYKAEWRAVGEEVWHSK 629
Score = 54.4 bits (125), Expect = 4e-06
Identities = 25/79 (31%), Positives = 41/79 (51%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G +V C EG+P P ++W + I+ +D + Y D+ + L I++V D + C
Sbjct: 309 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 368
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N AG +T L V A
Sbjct: 369 IAENKAGEQDATIHLKVFA 387
Score = 48.0 bits (109), Expect = 4e-04
Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P A Y EG+ + + C + A P I+W F+ +++P N S I+ S L++T
Sbjct: 492 PVAVYTWEGNQVNITCEVFAYPSATISW-FRDGQLLPSSNYS-NIKIYNTPSASYLEVTP 549
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKS 743
+ G Y AVNR G+ SL +L ++ P + +EP S
Sbjct: 550 DSENDFGNYNCTAVNRIGQESLEFIL-VQADTPSSPSIDQVEPYSS 594
Score = 45.6 bits (103), Expect = 0.002
Identities = 44/189 (23%), Positives = 85/189 (44%), Gaps = 7/189 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSW-TKIVTVGGSVHE 1924
PS P V E S + +++ EPE+ GG PI Y E++ V + W +K + E
Sbjct: 581 PSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 639
Query: 1925 HCIENIKEKDEIIF--RISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNI 1982
+ + K E + R++A N G+ + + + + PS P ++ G++I
Sbjct: 640 GIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSI 699
Query: 1983 VMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+ + DGG+P+ Y + R ++ + W ++ + ++ L N Y + +
Sbjct: 700 KVNL--IKQDDGGSPIRHYLVRYRALS-SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 756
Query: 2043 ARNEIGLSE 2051
A N+ G S+
Sbjct: 757 AENQQGKSK 765
Score = 41.1 bits (92), Expect = 0.042
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 4/85 (4%)
Query: 520 HTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQ--MYYDDDNVATLVIREVFPED 577
+T +G+ V C+V YP I+WFR ++ PS ++ Y+ + + L + D
Sbjct: 496 YTWEGNQVNITCEVFAYPSATISWFRDGQLL-PSSNYSNIKIYNTPSASYLEVTPDSEND 554
Query: 578 AGTFTCVAKNAAGFASSTTELIVEA 602
G + C A N G S ++V+A
Sbjct: 555 FGNYNCTAVNRIG-QESLEFILVQA 578
Score = 40.7 bits (91), Expect = 0.056
Identities = 33/131 (25%), Positives = 53/131 (40%), Gaps = 3/131 (2%)
Query: 524 GSTVQFECQVEGYPRPQ-ITWFRQTAI-IKPSQD-FQMYYDDDNVATLVIREVFPEDAGT 580
G + F CQV G + + I+WF + P+Q + ++DD+ +TL I +DAG
Sbjct: 115 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 174
Query: 581 FTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKP 640
+ CV G S T + + T D++ +PPT K
Sbjct: 175 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 234
Query: 641 KAQYVDEGSDI 651
K + V D+
Sbjct: 235 KGRDVILKKDV 245
Score = 36.7 bits (81), Expect = 0.91
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 4/79 (5%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQ---DFQMYYDDD-NVATLVIREVFPEDAGTFT 582
V C+ G P P ITW T I + D M V++L ++ + DAG +
Sbjct: 406 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 465
Query: 583 CVAKNAAGFASSTTELIVE 601
C A N G S + L V+
Sbjct: 466 CTASNTIGQDSQSMYLEVQ 484
>AY310398-1|AAP75619.1| 2213|Homo sapiens sidekick-like protein 1
protein.
Length = 2213
Score = 97.5 bits (232), Expect = 5e-19
Identities = 120/443 (27%), Positives = 178/443 (40%), Gaps = 49/443 (11%)
Query: 533 VEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFA 592
+ YPRPQ+TWFR+ I PS + ++ LVI DAG + A N
Sbjct: 215 ITSYPRPQVTWFREGHKIIPSNRIAITLENQ----LVILATTTSDAGAYYVQAVNEKNGE 270
Query: 593 SSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGS-DI 651
+ T+ I + D G+ T+ PT P + V GS +
Sbjct: 271 NKTSPFIHLSIARDVGTPETMA-------------------PTIVVPPGNRSVVAGSSET 311
Query: 652 LLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVV 711
LEC A P D++ +K V I S +H + L I+N G Y
Sbjct: 312 TLECIASARPVEDLSVTWKRN--------GVRITSGLHSFGRHLTISNPTSADTGPYVCE 363
Query: 712 AVNREGEASLPIVLKIKTGEKEPPQ-VIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK 770
A G A P EPP EP + E+V + Q +G P PT+ W K
Sbjct: 364 AA-LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYK 422
Query: 771 NNKPVKAL--PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEE 828
+ + L P + + I K + +D G++ A N G +T + V
Sbjct: 423 DAISISRLQNPRYKVLASGGLRIQKLRP-EDSGIFQCFASNEGGEIQTHTYLDVTNIA-- 479
Query: 829 NAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII-SPSETITQNFDGEN 887
P+F R + TV + T L V+ P P+ITW R N I+ S S I + E+
Sbjct: 480 ----PVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLES 535
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVI 947
L I V + D+G+Y C A+N+ G S A T+ V T + H + + +G T
Sbjct: 536 GGLQIAPVFIQ-DAGNYTCYAANTEG--SLNASATLTVWNRTSIVHPPEDHVVIKGTTAT 592
Query: 948 LECQTSH--TVSTKWYHNKKEIS 968
L C +H VS ++ K ++
Sbjct: 593 LHCGATHDPRVSLRYVWKKDNVA 615
Score = 87.0 bits (206), Expect = 7e-16
Identities = 107/468 (22%), Positives = 180/468 (38%), Gaps = 30/468 (6%)
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG----PVI 1674
Y + ++ I L ++ ++ N G S + +V P V
Sbjct: 1122 YEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVT 1181
Query: 1675 MREISRESVTIEWKPPLD---DGGLELTKYAIEKHEPDNNRWIKVADV--DRDVETYCIQ 1729
+R S S+ + W P D +G E Y I+ D VA V DR + I+
Sbjct: 1182 VRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQS-SAVAQVVSDRLEREFTIE 1240
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWF 1789
+L E EY ++ A N VG SE + +T VPS + + + +TW
Sbjct: 1241 ELEEWMEYELQMQAFNAVGAGPW--SEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWT 1298
Query: 1790 P-SEKNGGSPIIDYKVEIKQEG----KKWKXXXXXXXXXARIQKLSINTTYQFRIYARNE 1844
E++ I+ YK+ + + + A + L Y+ ++ A
Sbjct: 1299 SVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTR 1358
Query: 1845 IGTSLPYTSDDKITIGKTLTP-PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
IG +P T + + +T P P V E SV + W PE G I Y I
Sbjct: 1359 IGNGVPSTP---LILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGI-ILGYQIA 1414
Query: 1904 FKTVKGKSWT-KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
++ T V VG +V + ++ + IFR+SA+ G P E+ + EK
Sbjct: 1415 YRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKR 1474
Query: 1963 ATVPSPPTAPLEIRM-VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV-GKVD 2020
P+PP L + V + + W P DG +P+ + + +R++ + W +
Sbjct: 1475 ER-PAPPRELLVPQAEVTARSLRLQW-VPGSDGASPIRYFTMQVRELPRGEWQTYSSSIS 1532
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIG---LSEPLESDEPFKVIPGE 2065
+ L +Y +R+ A N+IG S E+ + +PGE
Sbjct: 1533 HEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGE 1580
Score = 81.8 bits (193), Expect = 2e-14
Identities = 129/541 (23%), Positives = 210/541 (38%), Gaps = 48/541 (8%)
Query: 685 ESDMHMYCSVLK--ITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLK 742
+S++ Y S K I +++K G Y V NR G A L +++ + K
Sbjct: 142 DSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMG-ALLQRKSEVQVAYMGSFMDTDQRK 200
Query: 743 SMIVRQGESVILSA-QVVGNPRPTITWCKNNKPVKALPTKSDGDT-HSITILKPKKVKDE 800
+ V QG + IL+ + PRP +TW + K +P+ T + ++ D
Sbjct: 201 T--VSQGRAAILNLLPITSYPRPQVTWFREGH--KIIPSNRIAITLENQLVILATTTSDA 256
Query: 801 GVYTLKAENSE-GIAETSAVITV----EEPTEENAEPPLFINRFQEITVKEKGTIKLVAR 855
G Y ++A N + G +TS I + + T E P + + V L
Sbjct: 257 GAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECI 316
Query: 856 VTRNPVP--SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVAS--NS 911
+ PV S+TW RN IT L I+N S D+G Y C A+ S
Sbjct: 317 ASARPVEDLSVTWKRNGV------RITSGLHSFGRHLTISNPTSA-DTGPYVCEAALPGS 369
Query: 912 AGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTV--STKWYHNKKEISG 969
A + + +E F + E +TV + CQ + +WY + IS
Sbjct: 370 AFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISR 429
Query: 970 MDHR--EIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPEFIRKL 1023
+ + +++ G D G+ +C ++ +T T L V P F ++
Sbjct: 430 LQNPRYKVLASG---GLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRP 486
Query: 1024 QDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVH 1082
D V + AIL E++ + + W+R+ I+ + L I +
Sbjct: 487 VDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQ 546
Query: 1083 DEGEYSCIL--RDESCTAEVTV-VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL-VR 1138
D G Y+C + S A T+ V I+ ++ V KG AT T + +R
Sbjct: 547 DAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLR 606
Query: 1139 --WFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV----GNSKCTAILTVE 1192
W KD + S+ ++ ++ K L I D G+YSCE+ GN A L V
Sbjct: 607 YVWKKDNVALTPSSTSRIVVE-KDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVI 665
Query: 1193 E 1193
E
Sbjct: 666 E 666
Score = 70.5 bits (165), Expect = 6e-11
Identities = 118/503 (23%), Positives = 195/503 (38%), Gaps = 57/503 (11%)
Query: 635 TFSKKPKAQYVDEGSDILLECR-LVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
+F + + V +G +L + + P P + W +G +I+P I++ +E+ +
Sbjct: 192 SFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQL----- 246
Query: 694 VLKITNVKKFQEGTYTVVAVN-REGE------ASLPIVLKIKTGEKEPPQVIEPLKSMIV 746
V+ T G Y V AVN + GE L I + T E P ++ P + V
Sbjct: 247 VILATTTS--DAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSV 304
Query: 747 RQGESVILSAQVVGNPRP----TITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGV 802
G S + + + + RP ++TW +N + + S G +TI P D G
Sbjct: 305 VAGSSE-TTLECIASARPVEDLSVTWKRNGVRITS-GLHSFG--RHLTISNPTSA-DTGP 359
Query: 803 YTLKAE---NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRN 859
Y +A ++ A +A + + EP AEP I+ + + T+ + +
Sbjct: 360 YVCEAALPGSAFEPARATAFLFIIEPPYFTAEPE------SRISAEVEETVDIGCQAMGV 413
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P+P++ WY++ IS + L I + E DSG ++C ASN G+
Sbjct: 414 PLPTLQWYKDAISISRLQNPRYKVLASG-GLRIQKLRPE-DSGIFQCFASNEGGEIQ--T 469
Query: 920 RVTIDVEKVTFVKHLQKSYET--EEGKTVILECQTSHT--VSTKW-YHNKKEISGMDHRE 974
+DV + V Q+ +T +G T IL C+ S + W N SG
Sbjct: 470 HTYLDVTNIAPV-FTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIP 528
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETI---PEFIRKLQDFEVKEK 1031
D G C + E S T+ + +D V +
Sbjct: 529 RFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKG 588
Query: 1032 DVAILEVEINSE---TADVVWERDGEIIKPKK-NKYDFEKRGHIRKLYIRNTSVHDEGEY 1087
A L + + VW++D + P ++ EK G L I T D G+Y
Sbjct: 589 TTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDG---SLLISQTWSGDIGDY 645
Query: 1088 SCILRDE----SCTAEVTVVELP 1106
SC + E S A + V+ELP
Sbjct: 646 SCEIVSEGGNDSRMARLEVIELP 668
Score = 64.1 bits (149), Expect = 5e-09
Identities = 110/478 (23%), Positives = 181/478 (37%), Gaps = 59/478 (12%)
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG----TSSVEVTLKVYDKPSKPEGPVI 1674
Y+ + + + + L+ S K ++A+N G +S E + D P +P G V
Sbjct: 1527 YSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVS 1586
Query: 1675 MREISRESVTIEWKPPLDDG--GLELTKYAIEKHEPD------------NNRWIKVADV- 1719
+ SV I+W+PP D+ GL L Y I E + N A++
Sbjct: 1587 ATPHTTSSVLIQWQPPRDESLNGL-LQGYRIYYRELEYEAGSGTEAKTLKNPIALXAELT 1645
Query: 1720 ---------DRDVETYC-IQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSX 1769
T C + L + Y + A N +G S A S P+ + P+
Sbjct: 1646 AQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPA--SAPVEVFVGEAAPAM 1703
Query: 1770 XXXXXXXXXIDNESVYITWFP---SEKNG---GSPIIDYKVEIKQEGKKWKXXXXXXXXX 1823
+ + +TW P +NG G I ++ + + E +K K
Sbjct: 1704 APQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPV- 1762
Query: 1824 ARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKT-LTPPSQPRNFVVSESTSRSV 1882
R++ L+ +T Y I A N G P + + G+T P P SE TS ++
Sbjct: 1763 VRLKNLTSHTKYLVSISAFNAAGDG-PKSDPQQ---GRTHQAAPGAPSFLAFSEITSTTL 1818
Query: 1883 TLKWTEPESNGGSPITNYIIEFK---TVKGKSWTKIVTVGGSVHEHC-IENIKEKDEIIF 1938
+ W EP + G + Y + ++ V+G S V V G+ + ++ + F
Sbjct: 1819 NVSWGEPAAANGI-LQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFF 1877
Query: 1939 RISAEN-TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAP 1997
R+ A T G L + E P +P ++ + S +T T G P
Sbjct: 1878 RVQARTITYGPELQANITAGPAE------GSPGSPRDVLVTKSASELTLQWTEGHSGDTP 1931
Query: 1998 LLGYNIAIRDVTKTMW-MEVGKV--DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
GY I R + +W M V + + ++ L + TY R+ A NE G EP
Sbjct: 1932 TTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEP 1989
Score = 63.3 bits (147), Expect = 9e-09
Identities = 50/216 (23%), Positives = 96/216 (44%), Gaps = 11/216 (5%)
Query: 1781 NESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXX---XXARIQKLSINTTYQF 1837
+ +V ++W +G SPI+ Y VE+ + WK + L+ TYQF
Sbjct: 683 SHAVVLSWV-RPFDGNSPILYYIVELSENSSPWKVHLSNVGPEMTGVTVSGLTPARTYQF 741
Query: 1838 RIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKW-TEPESNGGSP 1896
R+ A NE+G Y+++ + P + P+N V S T++S+ ++W PE+
Sbjct: 742 RVCAVNEVGRG-QYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGV 800
Query: 1897 ITNYIIEFKT--VKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES 1954
+ YI+ ++ + G+ + +T V+ + ++ + +++A N G L S
Sbjct: 801 LRGYILRYRLAGLPGEYQQRNIT-SPEVNYCLVTDLIIWTQYEIQVAAYN--GAGLGVFS 857
Query: 1955 QSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP 1990
++V VP+ P ++ V S + W P
Sbjct: 858 RAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPP 893
Score = 61.7 bits (143), Expect = 3e-08
Identities = 102/467 (21%), Positives = 178/467 (38%), Gaps = 44/467 (9%)
Query: 1043 ETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC-------ILRDES 1095
E V W+R+G I + + R L I N + D G Y C
Sbjct: 323 EDLSVTWKRNGVRITSGLHSFG-------RHLTISNPTSADTGPYVCEAALPGSAFEPAR 375
Query: 1096 CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIEL-TKGDAL--VRWFKDG---SEIQFS 1149
TA + ++E P T +++ + T +I G L ++W+KD S +Q
Sbjct: 376 ATAFLFIIE--PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNP 433
Query: 1150 NHIQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEF 1205
+ L G L+I +D+G + C E G + L V + FT R P
Sbjct: 434 RYKVLASGG----LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQR-PVD 488
Query: 1206 ILVPANTDAYLTVEIPDETLD-VTWYKKKSVIED-TEKFTLISDVKKRTLIIRKCTEDDQ 1263
V A L E+ +TW ++ ++ + + ++ L I D
Sbjct: 489 TTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDA 548
Query: 1264 CEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
YTC + + + + + IV ++ + +G+ TL P+ + ++
Sbjct: 549 GNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYV 608
Query: 1323 -VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ T + K SL I + + D G Y + + G+ + +++ P
Sbjct: 609 WKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELP 668
Query: 1382 SPPGKPNILEIDSSS----INICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNI--TK 1435
P N+L +SS + + W P + GNS I+YY+VE E + + + N+
Sbjct: 669 HSP--QNLLVSPNSSHSHAVVLSWVRPFD-GNSPILYYIVELSENSSPWKVHLSNVGPEM 725
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP 1482
T ++ L +Y+FR AVNEV S T + +E P
Sbjct: 726 TGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPP 772
Score = 58.4 bits (135), Expect = 3e-07
Identities = 92/402 (22%), Positives = 153/402 (38%), Gaps = 30/402 (7%)
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDD--GGLELTKYAIEKHEPDNNRWIKVADVDRD- 1722
P+ P V ++ ++ W PP G+ Y + D + V + D
Sbjct: 869 PTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGIN-QGYKLLAWPADAPEAVTVVTIAPDF 927
Query: 1723 --VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXID 1780
V I L + Y V+ G + S P ++ T D P +D
Sbjct: 928 HGVHHGHITNLKKFTAYFTSVLCFTTPG--DGPPSTPQLVWTQEDKPGAVGHLSFTEILD 985
Query: 1781 NESVYITWF-PSEKNGGSPIIDYKVEIKQEGK---KWKXXXXXXXXXARIQKLSINTTYQ 1836
S+ ++W P EKNG I Y++ + G+ + +IQ LS TTY
Sbjct: 986 T-SLKVSWQEPLEKNG--IITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYT 1042
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
+ A +GT L +S I+ G P P N V+S + RS TL++ P +G +
Sbjct: 1043 IDVAAVTAVGTGLVTSST--ISSGVPPDLPGAPSNLVISNISPRSATLQF-RPGYDGKTS 1099
Query: 1897 ITNYIIEFKT---VKGKSWTKIVTVGGSVHEHCIE--NIKEKDEIIFRISAENTVGVSLP 1951
I+ +I+E + + W + +E N+ FR+ N VG S
Sbjct: 1100 ISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPY 1159
Query: 1952 TESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSW---GTPEWDGGAPLLGYNIAI--R 2006
+ S V A PT+ + +R + W +++G +GY I
Sbjct: 1160 SPSSRVIQTLQAPPDVAPTS-VTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRS 1218
Query: 2007 DVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
D+ + +V D +F I +L E Y +++ A N +G
Sbjct: 1219 DLQSSAVAQVVS-DRLEREFTIEELEEWMEYELQMQAFNAVG 1259
Score = 55.6 bits (128), Expect = 2e-06
Identities = 30/94 (31%), Positives = 45/94 (47%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
++AP+F ++ DG T C+V G P+P ITW R+ I+ +
Sbjct: 477 NIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESG 536
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
L I VF +DAG +TC A N G +++ L V
Sbjct: 537 GLQIAPVFIQDAGNYTCYAANTEGSLNASATLTV 570
Score = 53.2 bits (122), Expect = 1e-05
Identities = 42/199 (21%), Positives = 82/199 (41%), Gaps = 10/199 (5%)
Query: 1486 KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG---KKLKTAKATYENRXXXXXXXXXX 1542
+P I+ E E +++ C GVP P + WY+D +L+ +
Sbjct: 391 EPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRP 450
Query: 1543 XXXXXYKCIAFNDHGEVETSCVVGIQQ-KPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
++C A N+ GE++T + + PV T + G ++ + G P
Sbjct: 451 EDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFT--QRPVDTTVTDGMTAILRCEVSGAPK 508
Query: 1602 PEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTL 1660
P + W + + L + ++ ++I + + YT A+NT G+ + TL
Sbjct: 509 PAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATL 568
Query: 1661 KVYDKPS---KPEGPVIMR 1676
V+++ S PE V+++
Sbjct: 569 TVWNRTSIVHPPEDHVVIK 587
Score = 45.6 bits (103), Expect = 0.002
Identities = 35/137 (25%), Positives = 65/137 (47%), Gaps = 10/137 (7%)
Query: 1355 AGIYKLRLENNCGHAD-VEMNVTILDKPSPPGKPNIL-----EIDSSSINICWDEPENTG 1408
A I++L + G + +E V +K P P L E+ + S+ + W P + G
Sbjct: 1447 AYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQW-VPGSDG 1505
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKN-ITKTQTS--IQNLKTNSSYRFRAYAVNEVDISDAS 1465
S I Y+ ++ +E+ EW + + I+ T+ + L+ +SY+ R A N++ SD S
Sbjct: 1506 ASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFS 1565
Query: 1466 ETTEYYKVIKETKIQSP 1482
TE +++ + P
Sbjct: 1566 SETEAVTTLQDVPGEPP 1582
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/103 (27%), Positives = 51/103 (49%), Gaps = 8/103 (7%)
Query: 1370 DVEMNVTILDKPSPPGKPN--ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW 1427
+++ N+T PG P ++ +S + + W E ++G++ YV+E + D W
Sbjct: 1889 ELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEG-HSGDTPTTGYVIEARPSDEGLW 1947
Query: 1428 -ISVKNITKTQTS----IQNLKTNSSYRFRAYAVNEVDISDAS 1465
+ VK+I ++ TS + L+ +Y FR AVNE + S
Sbjct: 1948 DMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPS 1990
Score = 41.1 bits (92), Expect = 0.042
Identities = 25/75 (33%), Positives = 35/75 (46%), Gaps = 2/75 (2%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVA 585
TV CQ G P P + W++ I Q+ + Y L I+++ PED+G F C A
Sbjct: 403 TVDIGCQAMGVPLPTLQWYKDAISISRLQNPR--YKVLASGGLRIQKLRPEDSGIFQCFA 460
Query: 586 KNAAGFASSTTELIV 600
N G + T L V
Sbjct: 461 SNEGGEIQTHTYLDV 475
Score = 39.9 bits (89), Expect = 0.098
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 1/96 (1%)
Query: 1953 ESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM 2012
+S+ RLE SP + S+ V+ SW P +DG +P+L Y + + + +
Sbjct: 656 DSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRP-FDGNSPILYYIVELSENSSPW 714
Query: 2013 WMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
+ + V + L+ TY R+ A NE+G
Sbjct: 715 KVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVG 750
Score = 33.5 bits (73), Expect = 8.5
Identities = 35/166 (21%), Positives = 64/166 (38%), Gaps = 10/166 (6%)
Query: 1485 EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX 1544
E L I E N + LTC+ G + W RD +L TY +
Sbjct: 109 EPGLPQIHLEGNR-LVLTCLAEGSWPLEFKWMRDDSEL----TTYSSEYKYIIPSLQKLD 163
Query: 1545 XXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAV-IEGIPPPE 1603
Y+C+ N G + +Q + + + D ++ G ++ + I P P+
Sbjct: 164 AGFYRCVVRNRMGAL-LQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQ 222
Query: 1604 VIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASN 1649
V W++ G+K+ IT + + ++ S + Y ++A N
Sbjct: 223 VTWFREGHKIIPSNRIAITLENQLVIL---ATTTSDAGAYYVQAVN 265
>M32292-1|AAA35751.1| 750|Homo sapiens protein ( Human colorectal
tumor suppressor mRNA (DCC), 5' end. ).
Length = 750
Score = 97.1 bits (231), Expect = 6e-19
Identities = 109/522 (20%), Positives = 195/522 (37%), Gaps = 31/522 (5%)
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK--KLKTAKATYENRXXXXXXXXX 1541
+++P N+ +D L C G P P TW R + +L++ K +
Sbjct: 243 LQRP-SNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVT 301
Query: 1542 XXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C+ + + S + + P ++ + E+ T + G P
Sbjct: 302 DDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECT--VSGKPV 359
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P V W KNG+ + + I S +RI + +S Y A N AG + L
Sbjct: 360 PTVNWMKNGDVVIPSDYFQIV---GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQL- 415
Query: 1662 VYDKPSKPEGPVIMRE--------ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW 1713
+ KP+ P V+ +S V + W+PP + G T E DN
Sbjct: 416 IVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRER 475
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
++ + L Y FRV+A N G E+ + + + L VP
Sbjct: 476 ALNTTQPGSLQ-LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENL 534
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINT 1833
S+ ITW P G P+ Y++ + + +++ L T
Sbjct: 535 QAVST-SPTSILITWEPPAYANG-PVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFT 592
Query: 1834 TYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNG 1893
Y R A N G + ++DD + + P + P+N + SRS+ + W P S
Sbjct: 593 EYSLRFLAYNRYGPGV--STDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT 650
Query: 1894 GSP-ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT 1952
+ IT Y I + + ++ T+ + + +++ + F++SA G P+
Sbjct: 651 QNGFITGYKIRHRKTTRRG--EMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPS 708
Query: 1953 ESQSVRLEKH----ATVPSPPTAPLEIRMVGSNIVMTSWGTP 1990
+ ++ + VP P++ L +R +N ++ SW P
Sbjct: 709 NWYTAETPENDLDESQVPDQPSS-LHVR-PQTNCIIMSWTPP 748
Score = 78.6 bits (185), Expect = 2e-13
Identities = 94/393 (23%), Positives = 151/393 (38%), Gaps = 22/393 (5%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPE-PDIAWLFKGEEIVPDENISVAIESDMHMYCSV 694
F +P G ++LL+C + P I W G + + S+ +
Sbjct: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQN 101
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVIL 754
+ + K EG Y A G++ I K P + + +S+ G++V+L
Sbjct: 102 ILHSRHHKPDEGLYQCEA--SLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
Query: 755 SAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAENSEG 812
+V+G P PTI W KN + + +P S L+ +++ D G+Y A N
Sbjct: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
Query: 813 IAETSAVITVEEPTEENAEPPL-FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+ T V ++ L F+ R + E L V+ P PS TW R E
Sbjct: 220 -SRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEE 278
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV 931
+I G N L+I+NV + DSG Y CV + S A +T+ V F+
Sbjct: 279 VIQLRSKKYSLLGGSN--LLISNVTDD-DSGMYTCVVTYKNENISASAELTVLVPP-WFL 334
Query: 932 KHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
H Y E + EC S + W N + D+ +I+
Sbjct: 335 NHPSNLY-AYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV---GGSNLRILGV 390
Query: 990 XXXDVGVIKCIVKDQ----ETSTMLVV-KETIP 1017
D G +C+ +++ +TS L+V K IP
Sbjct: 391 VKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP 423
Score = 68.9 bits (161), Expect = 2e-10
Identities = 95/443 (21%), Positives = 174/443 (39%), Gaps = 42/443 (9%)
Query: 1083 DEGEYSC--ILRDE----SCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL 1136
DEG Y C L D S TA+V V P +++ ++ G+ + E+ G+ +
Sbjct: 111 DEGLYQCEASLGDSGSIISRTAKVAVAG-PLRFLSQTESVTAFMGDTVLLKCEVI-GEPM 168
Query: 1137 --VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA------I 1188
+ W K+ ++ + L+I D G Y C N + +
Sbjct: 169 PTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEV 228
Query: 1189 LTVEEPSIN---FTLRLPEFILVPANTDAYLTVEIPD-ETLDVTWYKKKSVIE-DTEKFT 1243
+ +P ++ + L+ P ++ DA L + TW + + VI+ ++K++
Sbjct: 229 RILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYS 288
Query: 1244 LISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRG 1302
L+ L+I T+DD YTCV+ E+ V PP +++
Sbjct: 289 LLGG---SNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYES 345
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
D+ P P W+ N ++ + + S +L I V +D G Y+
Sbjct: 346 MDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGS---NLRILGVVKSDEGFYQCVA 402
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNI---------LEIDSSSINICWDEPENTGNSTII 1413
EN G+A + I+ KP+ P + + + S + + W P +
Sbjct: 403 ENEAGNAQTSAQL-IVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQT 461
Query: 1414 YYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK 1472
+ V +E D E ++ Q ++ NLK + Y FR A NE E+++ K
Sbjct: 462 FTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNE---WGPGESSQPIK 518
Query: 1473 VIKETKIQSPTVEKPLKNITTEP 1495
V + ++Q P + L+ ++T P
Sbjct: 519 VATQPELQVPGPVENLQAVSTSP 541
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/94 (31%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+ + + ++FEC V G P P + W + ++ PS FQ+ + L
Sbjct: 331 PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV----GGSNLR 386
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
I V D G + CVA+N AG A ++ +LIV P
Sbjct: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP 420
Score = 51.6 bits (118), Expect = 3e-05
Identities = 32/124 (25%), Positives = 48/124 (38%), Gaps = 7/124 (5%)
Query: 596 TELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLEC 655
+ L++ D T A++ +PP F P Y E DI EC
Sbjct: 293 SNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFEC 352
Query: 656 RLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNR 715
+ P P + W+ G+ ++P + + S+ L+I V K EG Y VA N
Sbjct: 353 TVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSN-------LRILGVVKSDEGFYQCVAENE 405
Query: 716 EGEA 719
G A
Sbjct: 406 AGNA 409
Score = 44.8 bits (101), Expect = 0.003
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 3/81 (3%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G EC V GYP P TW R +I+ N L+I V +D+G +T
Sbjct: 253 EGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSN---LLISNVTDDDSGMYT 309
Query: 583 CVAKNAAGFASSTTELIVEAP 603
CV S++ EL V P
Sbjct: 310 CVVTYKNENISASAELTVLVP 330
>AY509035-1|AAS91662.1| 1386|Homo sapiens roundabout-like protein 3
protein.
Length = 1386
Score = 97.1 bits (231), Expect = 6e-19
Identities = 81/319 (25%), Positives = 134/319 (42%), Gaps = 23/319 (7%)
Query: 605 SDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPD 664
SD G + V A+++ P+F ++P Q V + + C + P P
Sbjct: 229 SDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPR 288
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
+ W + E+ I SD ++ I +V EGTYT VA N G A
Sbjct: 289 LRWRKEDGELPTGR---YEIRSDHSLW-----IGHVSAEDEGTYTCVAENSVGRAEASGS 340
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG 784
L + PPQ++ + + GESV + GNP P I W K V P++S
Sbjct: 341 LSVHV----PPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQ 396
Query: 785 DTHSITILKPKKVK-------DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN 837
T ++ ++ D G Y +A + G A++ ++ + + PP+ +
Sbjct: 397 PTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGL-PPVILQ 455
Query: 838 RFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDS 897
T+ ++ L RVT NP PS+ W ++ + + + + N L I NV
Sbjct: 456 GPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTM--ANGTLYIANV-Q 512
Query: 898 EIDSGDYKCVASNSAGKSS 916
E+D G Y CVA +S G+++
Sbjct: 513 EMDMGFYSCVAKSSTGEAT 531
Score = 75.8 bits (178), Expect = 2e-12
Identities = 116/487 (23%), Positives = 201/487 (41%), Gaps = 65/487 (13%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL-- 890
P + + ++ V L R P P+I WY+N ++ T+ ++ + L
Sbjct: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVA---TVREDPRAHRLLLPS 120
Query: 891 -------VITNVDSEIDSGDYKCVASNSAGKS-SHGARVTIDVEKVTFVKHLQKSYETEE 942
++ + D G Y CVA N G + S A + + V + F + +
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAV 179
Query: 943 GKTVILEC--QTSHTV-STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
G+ +LEC H S W + + + R I+ G+ D G+ C
Sbjct: 180 GEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKS---DAGMYVC 236
Query: 1000 IVK----DQETSTMLVVKETIPEFIRK-LQDFEVKEKDVAILEVEINSETADVVWER-DG 1053
+ ++E++ V+ P F+R+ + + + V L + W + DG
Sbjct: 237 VASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDG 296
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEII 1110
E+ +Y+ + H L+I + S DEG Y+C+ + AE + V +PP+++
Sbjct: 297 EL---PTGRYEI-RSDH--SLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV 350
Query: 1111 TRLQNQKVNKGNKATFEIELTKGD--ALVRWFKDGSEIQFSNHIQLTIDGK-----KQKL 1163
T+ Q+Q G F+ E TKG+ + W K+GS++ L G+ + +L
Sbjct: 351 TQPQDQMAAPGESVAFQCE-TKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQL 409
Query: 1164 KIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILV-PANTDAYL-- 1216
I DAG Y C+ G+ A+L ++ S++ LP IL PAN L
Sbjct: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLD---GLPPVILQGPANQTLVLGS 466
Query: 1217 TVEIP-----DETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
+V +P + V W K ++ D +F +++ TL I E D Y+CV
Sbjct: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMAN---GTLYIANVQEMDMGFYSCV- 522
Query: 1271 LDAKSTT 1277
AKS+T
Sbjct: 523 --AKSST 527
Score = 75.4 bits (177), Expect = 2e-12
Identities = 83/348 (23%), Positives = 148/348 (42%), Gaps = 48/348 (13%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V F C+V+G P P++ W ++ + P+ +++ D +L I V ED GT+TCVA+
Sbjct: 275 VTFLCEVKGDPPPRLRWRKEDGEL-PTGRYEIRSDH----SLWIGHVSAEDEGTYTCVAE 329
Query: 587 NAAGFASSTTELIVEAP---LSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
N+ G A ++ L V P ++ +M +G PP P
Sbjct: 330 NSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCET-----KGNPP-----PAIF 379
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
+ EGS +L LF + + P SV+ L IT V++
Sbjct: 380 WQKEGSQVL---------------LFPSQSLQPTGRFSVSPRGQ-------LNITAVQRG 417
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKE--PPQVIEPLKSMIVRQGESVILSAQVVGN 761
G Y AV+ G +L+IK + PP +++ + + G SV L +V GN
Sbjct: 418 DAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGN 477
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
P+P++ W K+ + ++ + + + + D G Y+ A++S G A S +
Sbjct: 478 PQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLK 537
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ E + +PP + + + +V +T+N + ++TW N
Sbjct: 538 MREDWGVSPDPPT-----EPSSPPGAPSQPVVTEITKNSI-TLTWKPN 579
Score = 70.9 bits (166), Expect = 5e-11
Identities = 114/532 (21%), Positives = 199/532 (37%), Gaps = 56/532 (10%)
Query: 1262 DQCEYTCVL---LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL-LVDYQAFPQP 1317
D+ YTCV L A ++ +EV + G L V + P+P
Sbjct: 137 DEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEP 196
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD-VEMNVT 1376
+ W K + K + I + L + +DAG+Y N G + V
Sbjct: 197 SVSW---RKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVM 253
Query: 1377 ILDKPSPPGKP--NILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNIT 1434
+L++PS +P ++ D+ +C + + + + E E+ T + +++
Sbjct: 254 VLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPR---LRWRKEDGELPTGRY-EIRS-- 307
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTE 1494
I ++ + A N V ++AS + + + V +P +
Sbjct: 308 DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVH-------VPPQLVTQPQDQMAA- 359
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKL---------KTAKATYENRXXXXXXXXXXXXX 1545
P E + C G P P + W ++G ++ T + + R
Sbjct: 360 PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVI----TISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A + G + ++ I+ + I Q +G + + G P
Sbjct: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P V W K+G L+ D T T + I ++ Y+ A ++ G ++ LK
Sbjct: 480 PSVRWKKDGQWLQGDDLQFKTMANGT--LYIANVQEMDMGFYSCVAKSSTGEATWSGWLK 537
Query: 1662 VY-------DKPSKPEGPV------IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
+ D P++P P ++ EI++ S+T+ WKP G +T Y IE P
Sbjct: 538 MREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPN-PQTGAAVTSYVIEAFSP 596
Query: 1709 -DNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPI 1758
N W VAD +ET+ + L N Y+F V A G SE + SEP+
Sbjct: 597 AAGNTWRTVAD-GVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPV 647
Score = 62.1 bits (144), Expect = 2e-08
Identities = 75/329 (22%), Positives = 127/329 (38%), Gaps = 24/329 (7%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIES 686
E P ++P V G L CR P P+I W G + D +
Sbjct: 60 EDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLP 119
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREG-EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
++ + + EG YT VA N G AS L++ + Q P +++
Sbjct: 120 SGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQ--SP-GNVV 176
Query: 746 VRQGESVILS-AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYT 804
V GE +L G+P P+++W K+ +K + + + K D G+Y
Sbjct: 177 VAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLK-SDAGMYV 235
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
A N G E++A + E P F+ R V + + V +P P +
Sbjct: 236 CVASNMAGERESAAAEVMV------LERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRL 289
Query: 865 TWYRNNEIISPSETITQNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W + + E T ++ + L I +V +E D G Y CVA NS G++ +++
Sbjct: 290 RWRKED-----GELPTGRYEIRSDHSLWIGHVSAE-DEGTYTCVAENSVGRAEASGSLSV 343
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQT 952
V + + G++V +C+T
Sbjct: 344 HVPPQLVTQ--PQDQMAAPGESVAFQCET 370
Score = 60.1 bits (139), Expect = 9e-08
Identities = 58/223 (26%), Positives = 97/223 (43%), Gaps = 34/223 (15%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ--TAIIKPSQDFQM--YYDDDNV 565
P V + + + G +V F+C+ +G P P I W ++ ++ PSQ Q +
Sbjct: 347 PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPR 406
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXX 625
L I V DAG + C A + AG ++ +A L G+
Sbjct: 407 GQLNITAVQRGDAGYYVCQAVSVAG------SILAKALLEIKGAS--------------- 445
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
L+G+PP + P Q + GS + L CR+ P+P + W G+ + D+ + +
Sbjct: 446 ---LDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDD---LQFK 499
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
+ M L I NV++ G Y+ VA + GEA+ LK++
Sbjct: 500 T---MANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMR 539
Score = 56.4 bits (130), Expect = 1e-06
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 9/113 (7%)
Query: 1864 TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSV 1922
+PP P VV+E T S+TL W +P G+ +T+Y+IE F G +W + V G +
Sbjct: 554 SPPGAPSQPVVTEITKNSITLTW-KPNPQTGAAVTSYVIEAFSPAAGNTW-RTVADGVQL 611
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLE 1974
H + ++ +F + A G+S P+ S+ VR T S P+ P+E
Sbjct: 612 ETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVR-----TQDSSPSRPVE 659
Score = 35.9 bits (79), Expect = 1.6
Identities = 38/157 (24%), Positives = 57/157 (36%), Gaps = 13/157 (8%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLE---------IRM 1977
I N++E D + A+++ G + + +R E P PPT P +
Sbjct: 508 IANVQEMDMGFYSCVAKSSTGEATWSGWLKMR-EDWGVSPDPPTEPSSPPGAPSQPVVTE 566
Query: 1978 VGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHT 2036
+ N + +W P GA + Y I A W V V + L N
Sbjct: 567 ITKNSITLTW-KPNPQTGAAVTSYVIEAFSPAAGNTWRTVAD-GVQLETHTVSGLQPNTI 624
Query: 2037 YMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEP 2073
Y+ + A GLSEP EP + S E+P
Sbjct: 625 YLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDP 661
Score = 33.5 bits (73), Expect = 8.5
Identities = 22/83 (26%), Positives = 34/83 (40%), Gaps = 7/83 (8%)
Query: 524 GSTVQFEC-QVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
G EC G+P P ++W + A +K + L++ DAG +
Sbjct: 180 GEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG----GKLMMSHTLKSDAGMYV 235
Query: 583 CVAKNAAGFASSTTE--LIVEAP 603
CVA N AG S +++E P
Sbjct: 236 CVASNMAGERESAAAEVMVLERP 258
>U63041-1|AAB04558.1| 848|Homo sapiens neural cell adhesion molecule
CD56 protein.
Length = 848
Score = 96.7 bits (230), Expect = 8e-19
Identities = 141/691 (20%), Positives = 270/691 (39%), Gaps = 60/691 (8%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTI---D 1157
T V L +I+ V + ++ D + WF E N ++++ D
Sbjct: 16 TAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWND 75
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEV---GNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
L IY+ ++DDAG Y C V S+ A + V+ P DA
Sbjct: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
Query: 1215 YLTVEIPDETLDVTWYKKKS---VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC--- 1268
+ ++ +K K +++ +F ++S+ L IR + D+ Y C
Sbjct: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGR 192
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYER--EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
+L + K +V PP I + G VTL+ D + FP+P W + +
Sbjct: 193 ILARGEINFKDIQVIVNVPPTIRARQNIVNATANLGQSVTLVCDAERFPEPTMSWTKDGE 252
Query: 1327 IIKKCKHTKPSIDSKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
I++ + + I S +S LTIKKV+ D Y EN G D +++ + KP
Sbjct: 253 QIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY 312
Query: 1386 KPN--ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQ- 1441
N +E++ C E +G+ I + W S +NI+ + ++
Sbjct: 313 VENQTAMELEEQVTLTC----EASGD-----------PIPSITWRTSTRNISSEEKTLDG 357
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASE--TTEYYKVIKET-----KIQ-SPTVEKPLKNITT 1493
++ S R + + + +DA E T + +++ ++Q +P ++ P+ T
Sbjct: 358 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW 417
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT----YENRXXXXXXXX--XXXXXXX 1547
E N+ + +TC P ++W+RDG+ L ++ + Y
Sbjct: 418 EGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 476
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGD-EWLVTAVIEGIP--PPEV 1604
Y C A N G+ E+ + +Q + S + ++ ++ G+P +
Sbjct: 477 YNCTAVNRIGQ-ESFEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKA 535
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD 1664
W G ++ + K Y+ ++ I LK + + A N G + +
Sbjct: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595
Query: 1665 KP--SKPEGPVIMREISRESVTIEWK-PPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
+P +P P + ++ + +I+ DDGG + Y + ++ ++ W +
Sbjct: 596 QPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV-RYRALSSEWKPEIRLPS 654
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVGFSEA 1752
+ ++ L+ N EY V+A+N G S+A
Sbjct: 655 GSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 685
Score = 88.6 bits (210), Expect = 2e-16
Identities = 130/655 (19%), Positives = 240/655 (36%), Gaps = 54/655 (8%)
Query: 1226 DVTWYKK--KSVIEDTEKFTLI-SDVKKRTLIIRKCTEDDQCEYTCVLL-DAKSTTKLKV 1281
D++W+ + + + ++ +++ +D TL I DD Y CV+ + S ++ V
Sbjct: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
Query: 1282 EVVEFPPKIV-DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V F + + + G D ++ D + P W + + K + + S
Sbjct: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
Query: 1341 KSASLTIKKVENTDAGIYK----LRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSS- 1395
+ L I+ ++ TD G Y+ + D+++ V + P+ + NI+ ++
Sbjct: 171 NNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV--PPTIRARQNIVNATANL 227
Query: 1396 --SINICWDE---PENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
S+ + D PE T + T +E QE D ++I + +Q +I+ + N
Sbjct: 228 GQSVTLVCDAERFPEPTMSWTKDGEQIE-QEEDDEKYIFSDD--SSQLTIKKVDKNDEAE 284
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ A N+ DA+ + + K T +++ T E E + LTC G P
Sbjct: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTA--------MELEEQVTLTCEASGDPI 336
Query: 1511 PKVTWYRDGKKLKTAKATYENR---------XXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
P +TW + + + + T + Y C A N G+
Sbjct: 337 PSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQ 396
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
S + +Q P + + G++ +T + P + W+++G L + NI
Sbjct: 397 SMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 453
Query: 1622 T--TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREIS 1679
S + + + Y A N G S E L D PS P + E
Sbjct: 454 KIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESFEFILVQADTPSSPS--IDQVEPY 511
Query: 1680 RESVTIEWKPPLDDGGLELTKYAIE----KHEPDNNRWIKVADVDRDVETYCIQKLNENC 1735
+ +++ P GG+ + KY E E +++W + + I L
Sbjct: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME-GIVTIVGLKPET 570
Query: 1736 EYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNG 1795
Y R+ A N G E + + PS D S+ + + +G
Sbjct: 571 TYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVNLI-KQDDG 628
Query: 1796 GSPIIDYKVEIKQEGKKWK--XXXXXXXXXARIQKLSINTTYQFRIYARNEIGTS 1848
GSPI Y V + +WK ++ L N Y+ + A N+ G S
Sbjct: 629 GSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683
Score = 84.6 bits (200), Expect = 3e-15
Identities = 94/400 (23%), Positives = 166/400 (41%), Gaps = 40/400 (10%)
Query: 593 SSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDIL 652
SS+T I A + D G V ++ F P Q EG D +
Sbjct: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
+ C +V+ P I W KG +++ +++ + S+ + L+I +KK EGTY
Sbjct: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-----NYLQIRGIKKTDEGTYRCEG 191
Query: 713 -VNREGEASLPIVLKIKTGEKEPPQV--IEPLKSMIVRQGESVILSAQVVGNPRPTITWC 769
+ GE + I+ PP + + + + G+SV L P PT++W
Sbjct: 192 RILARGEINFK---DIQVIVNVPPTIRARQNIVNATANLGQSVTLVCDAERFPEPTMSWT 248
Query: 770 KNNKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
K+ + ++ D+ +TI K K DE Y AEN G E A I +
Sbjct: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK-NDEAEYICIAENKAG--EQDATIHL--- 302
Query: 826 TEENAEPPL-FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
+ A+P + ++ + ++E+ + L + +P+PSITW + IS E + D
Sbjct: 303 -KVFAKPKITYVENQTAMELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEE---KTLD 356
Query: 885 GENIELVITNVDS-------EIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS 937
G + V S D+G+Y C ASN+ G+ S + ++V+ ++
Sbjct: 357 GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS--MYLEVQYAPKLQGPVAV 414
Query: 938 YETEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREI 975
Y T EG V + C+ + + W+ + + + ++ I
Sbjct: 415 Y-TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 453
Score = 84.6 bits (200), Expect = 3e-15
Identities = 74/299 (24%), Positives = 126/299 (42%), Gaps = 25/299 (8%)
Query: 628 ILEGIPPTFSKKPKA--QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
++ +PPT + + G + L C PEP ++W GE+I +E+ I
Sbjct: 206 VIVNVPPTIRARQNIVNATANLGQSVTLVCDAERFPEPTMSWTKDGEQIEQEEDDEKYIF 265
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
SD S L I V K E Y +A N+ GE I LK+ P++
Sbjct: 266 SDDS---SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA----KPKITYVENQTA 318
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGD----TH---SITILKPKKVK 798
+ E V L+ + G+P P+ITW + + + + DG +H S LK +
Sbjct: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
D G Y A N+ I + S + +E + P+ + + E + + V
Sbjct: 379 DAGEYICTASNT--IGQDSQSMYLEVQYAPKLQGPVAVYTW------EGNQVNITCEVFA 430
Query: 859 NPVPSITWYRNNEIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P +I+W+R+ +++ S + + ++ + + DSE D G+Y C A N G+ S
Sbjct: 431 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
Score = 74.1 bits (174), Expect = 5e-12
Identities = 111/530 (20%), Positives = 216/530 (40%), Gaps = 39/530 (7%)
Query: 1025 DFEVKEKDVAILEVEINSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRK-LYIRNTSVH 1082
+ V E + +V +++ D+ W +GE + P + + L I N ++
Sbjct: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
Query: 1083 DEGEYSCILRDESCT-AEVTV-VELPPEIITRLQN--QKVNKGNKATFEIELTKG-DALV 1137
D G Y C++ E + +E TV V++ +++ + Q+ +G A ++ +
Sbjct: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTI 149
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSIN 1197
W G ++ ++ + L+I D G Y CE G + ++ +
Sbjct: 150 IWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCE-GRILARGEINFKDIQVI 207
Query: 1198 F----TLRLPEFIL-VPANTDAYLTVEIPDETLD---VTWYKKKSVIE---DTEKFTLIS 1246
T+R + I+ AN +T+ E ++W K IE D EK+
Sbjct: 208 VNVPPTIRARQNIVNATANLGQSVTLVCDAERFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
Query: 1247 DVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYEREYRIKRGSDV 1305
D + T I+K ++D+ EY C+ + + + F PKI E + ++ V
Sbjct: 268 DSSQLT--IKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325
Query: 1306 TLLVDYQAFPQPNDEWIVNSKIIKKCK-----HTKPSIDSKSASLTIKKVENTDAGIYKL 1360
TL + P P+ W +++ I + H ++ +SLT+K ++ TDAG Y
Sbjct: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
Query: 1361 RLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQ 1420
N G M + + P G + + + +NI E ++TI ++ + Q
Sbjct: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITC-EVFAYPSATISWF-RDGQ 443
Query: 1421 EIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ 1480
+ ++ + ++K S + +S F Y V+ E+ E+ V +T
Sbjct: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN-RIGQESFEFILVQADTP-S 501
Query: 1481 SPTVE--KPLKNITTEPNEDIELTCIFGGVP--QPKVTWYRDGKKLKTAK 1526
SP+++ +P + ++ E T GGVP + K W G+++ +K
Sbjct: 502 SPSIDQVEPYSSTAQVQFDEPEAT---GGVPILKYKAEWRAVGEEVWHSK 548
Score = 59.7 bits (138), Expect = 1e-07
Identities = 76/347 (21%), Positives = 139/347 (40%), Gaps = 35/347 (10%)
Query: 864 ITWYR-NNEIISPSE---TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
I+W+ N E ++P++ ++ N D + L I N + + D+G YKCV + G S A
Sbjct: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSST-LTIYNANID-DAGIYKCVVTGEDGSESE-A 108
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKE-ISGMDHREII 976
V + + + K+ E EG+ ++ C ++ W H ++ I D R I+
Sbjct: 109 TVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC----IVKDQETSTMLVVKETIPEFIRKLQDF-----E 1027
D G +C + + + + V +P IR Q+
Sbjct: 169 LSNNYLQIRGIKKT--DEGTYRCEGRILARGEINFKDIQVIVNVPPTIRARQNIVNATAN 226
Query: 1028 VKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEY 1087
+ + + + E E + W +DGE I+ +++ + +L I+ +DE EY
Sbjct: 227 LGQSVTLVCDAERFPEPT-MSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
Query: 1088 SCILRDESCTAEVTV---VELPPEIITRLQNQ-KVNKGNKATFEIELTKGDAL--VRWFK 1141
CI +++ + T+ V P+ IT ++NQ + + T E GD + + W
Sbjct: 286 ICIAENKAGEQDATIHLKVFAKPK-ITYVENQTAMELEEQVTLTCE-ASGDPIPSITWRT 343
Query: 1142 -----DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS 1183
E H+ + + L + DAGEY C N+
Sbjct: 344 STRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
Score = 51.2 bits (117), Expect = 4e-05
Identities = 24/79 (30%), Positives = 40/79 (50%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G +V C E +P P ++W + I+ +D + Y D+ + L I++V D + C
Sbjct: 228 GQSVTLVCDAERFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N AG +T L V A
Sbjct: 288 IAENKAGEQDATIHLKVFA 306
Score = 46.4 bits (105), Expect = 0.001
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 5/106 (4%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P A Y EG+ + + C + A P I+W F+ +++P N S I+ S L++T
Sbjct: 411 PVAVYTWEGNQVNITCEVFAYPSATISW-FRDGQLLPSSNYS-NIKIYNTPSASYLEVTP 468
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKS 743
+ G Y AVNR G+ S +L ++ P + +EP S
Sbjct: 469 DSENDFGNYNCTAVNRIGQESFEFIL-VQADTPSSPSIDQVEPYSS 513
Score = 45.6 bits (103), Expect = 0.002
Identities = 44/189 (23%), Positives = 85/189 (44%), Gaps = 7/189 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSW-TKIVTVGGSVHE 1924
PS P V E S + +++ EPE+ GG PI Y E++ V + W +K + E
Sbjct: 500 PSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 558
Query: 1925 HCIENIKEKDEIIF--RISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNI 1982
+ + K E + R++A N G+ + + + + PS P ++ G++I
Sbjct: 559 GIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSI 618
Query: 1983 VMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+ + DGG+P+ Y + R ++ + W ++ + ++ L N Y + +
Sbjct: 619 KVNL--IKQDDGGSPIRHYLVRYRALS-SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 675
Query: 2043 ARNEIGLSE 2051
A N+ G S+
Sbjct: 676 AENQQGKSK 684
Score = 40.7 bits (91), Expect = 0.056
Identities = 33/131 (25%), Positives = 53/131 (40%), Gaps = 3/131 (2%)
Query: 524 GSTVQFECQVEGYPRPQ-ITWFRQTAI-IKPSQD-FQMYYDDDNVATLVIREVFPEDAGT 580
G + F CQV G + + I+WF + P+Q + ++DD+ +TL I +DAG
Sbjct: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
Query: 581 FTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKP 640
+ CV G S T + + T D++ +PPT K
Sbjct: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Query: 641 KAQYVDEGSDI 651
K + V D+
Sbjct: 154 KGRDVILKKDV 164
Score = 40.7 bits (91), Expect = 0.056
Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 3/73 (4%)
Query: 520 HTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQ--MYYDDDNVATLVIREVFPED 577
+T +G+ V C+V YP I+WFR ++ PS ++ Y+ + + L + D
Sbjct: 415 YTWEGNQVNITCEVFAYPSATISWFRDGQLL-PSSNYSNIKIYNTPSASYLEVTPDSEND 473
Query: 578 AGTFTCVAKNAAG 590
G + C A N G
Sbjct: 474 FGNYNCTAVNRIG 486
Score = 36.7 bits (81), Expect = 0.91
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 4/79 (5%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQ---DFQMYYDDD-NVATLVIREVFPEDAGTFT 582
V C+ G P P ITW T I + D M V++L ++ + DAG +
Sbjct: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
Query: 583 CVAKNAAGFASSTTELIVE 601
C A N G S + L V+
Sbjct: 385 CTASNTIGQDSQSMYLEVQ 403
>AK056544-1|BAB71212.1| 1034|Homo sapiens protein ( Homo sapiens
cDNA FLJ31982 fis, clone NT2RP7008550, highly similar to
Mus musculus rig-1 protein mRNA. ).
Length = 1034
Score = 96.7 bits (230), Expect = 8e-19
Identities = 81/319 (25%), Positives = 134/319 (42%), Gaps = 23/319 (7%)
Query: 605 SDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPD 664
SD G + V A+++ P+F ++P Q V + + C + P P
Sbjct: 229 SDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPR 288
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
+ W + E+ I SD ++ I +V EGTYT VA N G A
Sbjct: 289 LRWRKEDGELPTGR---YEIRSDHSLW-----IGHVSAEDEGTYTCVAENSVGRAEASGS 340
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDG 784
L + PPQ++ + + GESV + GNP P I W K V P++S
Sbjct: 341 LSVHV----PPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQ 396
Query: 785 DTHSITILKPKKVK-------DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFIN 837
T ++ ++ D G Y +A + G A++ ++ + + PP+ +
Sbjct: 397 PTGRFSVSPRGQLNITAVQRGDAGYYMCQAVSVAGSILAKALLEIKGASLDGL-PPVILQ 455
Query: 838 RFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDS 897
T+ ++ L RVT NP PS+ W ++ + + + + N L I NV
Sbjct: 456 GPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTM--ANGTLYIANV-Q 512
Query: 898 EIDSGDYKCVASNSAGKSS 916
E+D G Y CVA +S G+++
Sbjct: 513 EMDMGFYSCVAKSSTGEAT 531
Score = 76.2 bits (179), Expect = 1e-12
Identities = 116/487 (23%), Positives = 201/487 (41%), Gaps = 65/487 (13%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIEL-- 890
P + + ++ V L R P P+I WY+N ++ T+ ++ + L
Sbjct: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVA---TVREDPRAHRLLLPS 120
Query: 891 -------VITNVDSEIDSGDYKCVASNSAGKS-SHGARVTIDVEKVTFVKHLQKSYETEE 942
++ + D G Y CVA N G + S A + + V + F + +
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAV 179
Query: 943 GKTVILEC--QTSHTV-STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC 999
G+ +LEC H S W + + + R I+ G+ D G+ C
Sbjct: 180 GEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKS---DAGMYVC 236
Query: 1000 IVK----DQETSTMLVVKETIPEFIRK-LQDFEVKEKDVAILEVEINSETADVVWER-DG 1053
+ ++E++ V+ P F+R+ + + + V L + W + DG
Sbjct: 237 VASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDG 296
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVT---VVELPPEII 1110
E+ +Y+ + H L+I + S DEG Y+C+ + AE + V +PP+++
Sbjct: 297 EL---PTGRYEI-RSDH--SLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV 350
Query: 1111 TRLQNQKVNKGNKATFEIELTKGD--ALVRWFKDGSEIQFSNHIQLTIDGK-----KQKL 1163
T+ Q+Q G F+ E TKG+ + W K+GS++ L G+ + +L
Sbjct: 351 TQPQDQMAAPGESVAFQCE-TKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQL 409
Query: 1164 KIYDCDLDDAGEYSCE----VGNSKCTAILTVEEPSINFTLRLPEFILV-PANTDAYL-- 1216
I DAG Y C+ G+ A+L ++ S++ LP IL PAN L
Sbjct: 410 NITAVQRGDAGYYMCQAVSVAGSILAKALLEIKGASLD---GLPPVILQGPANQTLVLGS 466
Query: 1217 TVEIP-----DETLDVTWYKKKSVIE-DTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVL 1270
+V +P + V W K ++ D +F +++ TL I E D Y+CV
Sbjct: 467 SVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMAN---GTLYIANVQEMDMGFYSCV- 522
Query: 1271 LDAKSTT 1277
AKS+T
Sbjct: 523 --AKSST 527
Score = 74.9 bits (176), Expect = 3e-12
Identities = 83/348 (23%), Positives = 148/348 (42%), Gaps = 48/348 (13%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V F C+V+G P P++ W ++ + P+ +++ D +L I V ED GT+TCVA+
Sbjct: 275 VTFLCEVKGDPPPRLRWRKEDGEL-PTGRYEIRSDH----SLWIGHVSAEDEGTYTCVAE 329
Query: 587 NAAGFASSTTELIVEAP---LSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQ 643
N+ G A ++ L V P ++ +M +G PP P
Sbjct: 330 NSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCET-----KGNPP-----PAIF 379
Query: 644 YVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKF 703
+ EGS +L LF + + P SV+ L IT V++
Sbjct: 380 WQKEGSQVL---------------LFPSQSLQPTGRFSVSPRGQ-------LNITAVQRG 417
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKE--PPQVIEPLKSMIVRQGESVILSAQVVGN 761
G Y AV+ G +L+IK + PP +++ + + G SV L +V GN
Sbjct: 418 DAGYYMCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGN 477
Query: 762 PRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
P+P++ W K+ + ++ + + + + D G Y+ A++S G A S +
Sbjct: 478 PQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLK 537
Query: 822 VEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ E + +PP + + + +V +T+N + ++TW N
Sbjct: 538 MREDWGVSPDPPT-----EPSSPPGAPSQPVVTEITKNSI-TLTWKPN 579
Score = 71.3 bits (167), Expect = 3e-11
Identities = 114/532 (21%), Positives = 199/532 (37%), Gaps = 56/532 (10%)
Query: 1262 DQCEYTCVL---LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTL-LVDYQAFPQP 1317
D+ YTCV L A ++ +EV + G L V + P+P
Sbjct: 137 DEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEP 196
Query: 1318 NDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD-VEMNVT 1376
+ W K + K + I + L + +DAG+Y N G + V
Sbjct: 197 SVSW---RKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVM 253
Query: 1377 ILDKPSPPGKP--NILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNIT 1434
+L++PS +P ++ D+ +C + + + + E E+ T + +++
Sbjct: 254 VLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPR---LRWRKEDGELPTGRY-EIRS-- 307
Query: 1435 KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTE 1494
I ++ + A N V ++AS + + + V +P +
Sbjct: 308 DHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVH-------VPPQLVTQPQDQMAA- 359
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKL---------KTAKATYENRXXXXXXXXXXXXX 1545
P E + C G P P + W ++G ++ T + + R
Sbjct: 360 PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPV----ITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
Y C A + G + ++ I+ + I Q +G + + G P
Sbjct: 420 GYYMCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQ 479
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
P V W K+G L+ D T T + I ++ Y+ A ++ G ++ LK
Sbjct: 480 PSVRWKKDGQWLQGDDLQFKTMANGT--LYIANVQEMDMGFYSCVAKSSTGEATWSGWLK 537
Query: 1662 VY-------DKPSKPEGP------VIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
+ D P++P P ++ EI++ S+T+ WKP G +T Y IE P
Sbjct: 538 MREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPN-PQTGAAVTSYVIEAFSP 596
Query: 1709 -DNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPI 1758
N W VAD +ET+ + L N Y+F V A G SE + SEP+
Sbjct: 597 AAGNTWRTVAD-GVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPV 647
Score = 62.1 bits (144), Expect = 2e-08
Identities = 75/329 (22%), Positives = 127/329 (38%), Gaps = 24/329 (7%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIES 686
E P ++P V G L CR P P+I W G + D +
Sbjct: 60 EDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLP 119
Query: 687 DMHMYCSVLKITNVKKFQEGTYTVVAVNREG-EASLPIVLKIKTGEKEPPQVIEPLKSMI 745
++ + + EG YT VA N G AS L++ + Q P +++
Sbjct: 120 SGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQ--SP-GNVV 176
Query: 746 VRQGESVILS-AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYT 804
V GE +L G+P P+++W K+ +K + + + K D G+Y
Sbjct: 177 VAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLK-SDAGMYV 235
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
A N G E++A + E P F+ R V + + V +P P +
Sbjct: 236 CVASNMAGERESAAAEVMV------LERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRL 289
Query: 865 TWYRNNEIISPSETITQNFD-GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W + + E T ++ + L I +V +E D G Y CVA NS G++ +++
Sbjct: 290 RWRKED-----GELPTGRYEIRSDHSLWIGHVSAE-DEGTYTCVAENSVGRAEASGSLSV 343
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQT 952
V + + G++V +C+T
Sbjct: 344 HVPPQLVTQ--PQDQMAAPGESVAFQCET 370
Score = 59.7 bits (138), Expect = 1e-07
Identities = 58/223 (26%), Positives = 97/223 (43%), Gaps = 34/223 (15%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ--TAIIKPSQDFQM--YYDDDNV 565
P V + + + G +V F+C+ +G P P I W ++ ++ PSQ Q +
Sbjct: 347 PQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPR 406
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXX 625
L I V DAG + C A + AG ++ +A L G+
Sbjct: 407 GQLNITAVQRGDAGYYMCQAVSVAG------SILAKALLEIKGAS--------------- 445
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
L+G+PP + P Q + GS + L CR+ P+P + W G+ + D+ + +
Sbjct: 446 ---LDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDD---LQFK 499
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
+ M L I NV++ G Y+ VA + GEA+ LK++
Sbjct: 500 T---MANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMR 539
Score = 56.4 bits (130), Expect = 1e-06
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 9/113 (7%)
Query: 1864 TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSV 1922
+PP P VV+E T S+TL W +P G+ +T+Y+IE F G +W + V G +
Sbjct: 554 SPPGAPSQPVVTEITKNSITLTW-KPNPQTGAAVTSYVIEAFSPAAGNTW-RTVADGVQL 611
Query: 1923 HEHCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLE 1974
H + ++ +F + A G+S P+ S+ VR T S P+ P+E
Sbjct: 612 ETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVR-----TQDSSPSRPVE 659
Score = 35.9 bits (79), Expect = 1.6
Identities = 38/157 (24%), Positives = 57/157 (36%), Gaps = 13/157 (8%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLE---------IRM 1977
I N++E D + A+++ G + + +R E P PPT P +
Sbjct: 508 IANVQEMDMGFYSCVAKSSTGEATWSGWLKMR-EDWGVSPDPPTEPSSPPGAPSQPVVTE 566
Query: 1978 VGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHT 2036
+ N + +W P GA + Y I A W V V + L N
Sbjct: 567 ITKNSITLTW-KPNPQTGAAVTSYVIEAFSPAAGNTWRTVAD-GVQLETHTVSGLQPNTI 624
Query: 2037 YMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEP 2073
Y+ + A GLSEP EP + S E+P
Sbjct: 625 YLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDP 661
Score = 33.5 bits (73), Expect = 8.5
Identities = 22/83 (26%), Positives = 34/83 (40%), Gaps = 7/83 (8%)
Query: 524 GSTVQFEC-QVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
G EC G+P P ++W + A +K + L++ DAG +
Sbjct: 180 GEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG----GKLMMSHTLKSDAGMYV 235
Query: 583 CVAKNAAGFASSTTE--LIVEAP 603
CVA N AG S +++E P
Sbjct: 236 CVASNMAGERESAAAEVMVLERP 258
>BC044226-1|AAH44226.1| 477|Homo sapiens myosin binding protein H
protein.
Length = 477
Score = 96.3 bits (229), Expect = 1e-18
Identities = 68/302 (22%), Positives = 136/302 (45%), Gaps = 21/302 (6%)
Query: 1282 EVVEFPP-KIVDYEREYRIKR-GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
E +E P ++ + R+ I++ G V L + +Q P+P W N + + + + D
Sbjct: 167 ENIEAPKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGD 226
Query: 1340 SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINI 1399
S L I+ + +D+G Y+L + A +++ +++KP PP +L++ + +
Sbjct: 227 QDSI-LFIRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPSSIRLLDVWGCNAAL 285
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
W P++TGN+ ++ Y+V+ + T +W +V + T +I +L +SY FR ++ N
Sbjct: 286 QWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSENL 345
Query: 1459 VDISDASETTEYYKVIKETKI-------------QSPTVEKPLKNITTEPNEDIELTCIF 1505
+S ++ T+ I++ I ++P+ +PL + T+ P +L C
Sbjct: 346 CGLSTSATVTKELAHIQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSV 405
Query: 1506 GGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
P+PK+ W ++ ++ K + + Y C A N GE
Sbjct: 406 RASPKPKIIWMKNKMEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASV 465
Query: 1562 SC 1563
C
Sbjct: 466 DC 467
Score = 72.5 bits (170), Expect = 1e-11
Identities = 43/167 (25%), Positives = 81/167 (48%), Gaps = 5/167 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VG+ + +G P P+ W NG+ L++ + ++ T ++ S++ I+ +RS S +Y
Sbjct: 187 QVGETVNLQIPFQGKPKPQATWTHNGHALDSQR-VSMRTGDQDSILFIRSAQRSDSGRYE 245
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+ + + + V +KP P + + ++ + ++W PP D G EL Y ++
Sbjct: 246 LTVRVEDLEAKAVIDILVIEKPGPPSS-IRLLDVWGCNAALQWTPPQDTGNTELLGYMVQ 304
Query: 1705 KHEPDNNRWIKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFS 1750
K + +W V ++R T C I L Y FRV ++N G S
Sbjct: 305 KADKKTGQWFTV--LERYHPTTCTISDLIIGNSYSFRVFSENLCGLS 349
Score = 61.3 bits (142), Expect = 4e-08
Identities = 37/155 (23%), Positives = 69/155 (44%), Gaps = 7/155 (4%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
D PS P + ++ SSS+ + W+ PE G + YV+E +EW +S + + T
Sbjct: 69 DVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMVT 128
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP---LKNITT 1493
Q +++NL + R AV+ + + + I++P + P +
Sbjct: 129 QQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHI--RENIEAPKIRVPRHLRQTYIR 186
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT 1528
+ E + L F G P+P+ TW +G L + + +
Sbjct: 187 QVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVS 221
Score = 56.8 bits (131), Expect = 8e-07
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 4/114 (3%)
Query: 492 IDKLPVFEKPTS---EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
I K + KP + S AP F + L + G + Q C V P+P+I W +
Sbjct: 361 IQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKM 420
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
I+ + ++ + V TL IR+ P D+G +TC A N G AS L V+A
Sbjct: 421 EIQGNPKYRAL-SEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVKA 473
Score = 46.8 bits (106), Expect = 9e-04
Identities = 24/102 (23%), Positives = 44/102 (43%), Gaps = 1/102 (0%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
PS P + + +S SVT+ W PE G + Y++E W + V +
Sbjct: 71 PSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMVTQQ 130
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVP 1966
+ N+ D+ + R+SA ++ G P Q + + ++ P
Sbjct: 131 TVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIRENIEAP 172
Score = 45.6 bits (103), Expect = 0.002
Identities = 35/150 (23%), Positives = 62/150 (41%), Gaps = 4/150 (2%)
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR--EI 1678
+ T E + + E R + A T+S T P P+++ ++
Sbjct: 24 VPTAEPPGEVAVSESTREEQVPKPQAPAPQAPTAST-ATKPAPPSEDVPSAPLLLTLDDV 82
Query: 1679 SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYM 1738
S SVT+ W+PP G L L Y +E + W+ V+ V ++ L +++
Sbjct: 83 SSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMVTQQTVRNLALGDKFL 142
Query: 1739 FRVIAQNPVGFS-EALESEPIVIKTALDVP 1767
RV A + G A+ +PI I+ ++ P
Sbjct: 143 LRVSAVSSAGAGPPAMLDQPIHIRENIEAP 172
Score = 45.2 bits (102), Expect = 0.003
Identities = 65/299 (21%), Positives = 114/299 (38%), Gaps = 31/299 (10%)
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXX 1823
DVPS + + SV ++W P E+ G + Y +E+ +EG +W
Sbjct: 69 DVPSAPLLLTLDD-VSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMV 127
Query: 1824 AR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS--QPRNFVVSESTS 1879
+ ++ L++ + R+ A + G P D I I + + P PR+
Sbjct: 128 TQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIRENIEAPKIRVPRH-------- 179
Query: 1880 RSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE-NIKEKDEIIF 1938
L+ T G + + K +WT G ++ + ++D I+F
Sbjct: 180 ----LRQTYIRQVGETVNLQIPFQGKPKPQATWTHN---GHALDSQRVSMRTGDQDSILF 232
Query: 1939 RISAENTVGVSLPTESQSVRLEKHATV-------PSPPTAPLEIRMVGSNIVMTSWGTPE 1991
SA+ + + LE A + P PP++ + + G N + W P+
Sbjct: 233 IRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPSSIRLLDVWGCNAAL-QWTPPQ 291
Query: 1992 WDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLS 2050
G LLGY + D W V + + I DL ++Y R+++ N GLS
Sbjct: 292 DTGNTELLGYMVQKADKKTGQWFTVLE-RYHPTTCTISDLIIGNSYSFRVFSENLCGLS 349
Score = 43.6 bits (98), Expect = 0.008
Identities = 30/94 (31%), Positives = 40/94 (42%), Gaps = 4/94 (4%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSI 789
E P +PL G S L V +P+P I W KN ++ P S+ ++
Sbjct: 380 EAPSFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKMEIQGNPKYRALSEQGVCTL 439
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
I KP D GVYT KA N G A + V+
Sbjct: 440 EIRKPSPF-DSGVYTCKAINVLGEASVDCRLEVK 472
Score = 43.2 bits (97), Expect = 0.010
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 7/106 (6%)
Query: 1963 ATVPSPPT-----APLEIRM--VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWME 2015
AT P+PP+ APL + + V S+ V SW PE G L GY + + + W+
Sbjct: 60 ATKPAPPSEDVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVP 119
Query: 2016 VGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
V + + +R+L+ +++R+ A + G P D+P +
Sbjct: 120 VSARPMMVTQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHI 165
Score = 42.7 bits (96), Expect = 0.014
Identities = 18/67 (26%), Positives = 36/67 (53%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ P P++IW KN +++ + +Y +++ + I++ S YT +A N G +S
Sbjct: 405 VRASPKPKIIWMKNKMEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEAS 464
Query: 1656 VEVTLKV 1662
V+ L+V
Sbjct: 465 VDCRLEV 471
Score = 39.9 bits (89), Expect = 0.098
Identities = 29/99 (29%), Positives = 48/99 (48%), Gaps = 7/99 (7%)
Query: 733 EPPQVIEP--LKSMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPVKA-LPTKSDGDTHS 788
E P++ P L+ +RQ GE+V L G P+P TW N + + + GD S
Sbjct: 170 EAPKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGDQDS 229
Query: 789 ITILKPKKVKDEGVY--TLKAENSEGIAETSAVITVEEP 825
I ++ + D G Y T++ E+ E A ++ +E+P
Sbjct: 230 ILFIRSAQRSDSGRYELTVRVEDLEAKAVID-ILVIEKP 267
Score = 39.1 bits (87), Expect = 0.17
Identities = 30/96 (31%), Positives = 45/96 (46%), Gaps = 6/96 (6%)
Query: 634 PTFSKKPKAQYVDE-GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P+F++ P A + G L C + A P+P I W+ EI + E + C
Sbjct: 382 PSFTQ-PLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKMEIQGNPKYRALSEQGV---C 437
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
+ L+I F G YT A+N GEAS+ L++K
Sbjct: 438 T-LEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVK 472
Score = 34.3 bits (75), Expect = 4.9
Identities = 19/90 (21%), Positives = 39/90 (43%), Gaps = 2/90 (2%)
Query: 1786 ITWFPSEKNGGSPIIDYKVEI--KQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
+ W P + G + ++ Y V+ K+ G+ + I L I +Y FR+++ N
Sbjct: 285 LQWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSEN 344
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFV 1873
G S T ++ + ++P+ F+
Sbjct: 345 LCGLSTSATVTKELAHIQKADIAAKPKGFI 374
>AL390252-10|CAI13179.1| 354|Homo sapiens myosin binding protein
H-like protein.
Length = 354
Score = 96.3 bits (229), Expect = 1e-18
Identities = 72/317 (22%), Positives = 138/317 (43%), Gaps = 22/317 (6%)
Query: 1273 AKSTTKLKVEVVEFPPKIV---DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIK 1329
A S T + +E PKI + Y K G V LL+ +Q P+P W + +
Sbjct: 36 AGSPTPQLLPPIEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQAIWTHDGCALD 95
Query: 1330 KCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNI 1389
+ + + L I++ + D+G Y+LR++ A +++ ++++P PP +
Sbjct: 96 T-RRVSVRNGEQDSILFIREAQRADSGRYQLRVQLGGLEATATIDILVIERPGPPQSIKL 154
Query: 1390 LEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSS 1448
+++ S + W P++TGN+ ++ Y V+ + + W +V ++ +T + +L +S
Sbjct: 155 VDVWGFSATLEWTPPQDTGNTALLGYTVQKADTKSGLWFTVLEHYHRTSCIVSDLIIGNS 214
Query: 1449 YRFRAYAVNEVDISD-ASETTEYYKVIKETKI------------QSPTVEKPLKNITTEP 1495
Y FR +A N+ +S+ A TT+ + K + ++P +PL + TT
Sbjct: 215 YAFRVFAENQCGLSETAPITTDLAHIQKAATVYKTKGFAQRDFSEAPKFTQPLADCTTVT 274
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCI 1551
+ +L C P+PK+ W ++ + K T+ Y C
Sbjct: 275 GYNTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCK 334
Query: 1552 AFNDHGEVETSCVVGIQ 1568
A N GE C V ++
Sbjct: 335 AVNPLGEASVDCRVDVK 351
Score = 80.2 bits (189), Expect = 7e-14
Identities = 47/168 (27%), Positives = 82/168 (48%), Gaps = 5/168 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
KVGD + +G P P+ IW +G L+ + ++ E+ S++ I+E +R+ S +Y
Sbjct: 66 KVGDTVNLLIPFQGKPKPQAIWTHDGCALDT-RRVSVRNGEQDSILFIREAQRADSGRYQ 124
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+ ++ + + V ++P P+ + + ++ S T+EW PP D G L Y ++
Sbjct: 125 LRVQLGGLEATATIDILVIERPGPPQS-IKLVDVWGFSATLEWTPPQDTGNTALLGYTVQ 183
Query: 1705 KHEPDNNRWIKVADVDRDVETYCI-QKLNENCEYMFRVIAQNPVGFSE 1751
K + + W V ++ T CI L Y FRV A+N G SE
Sbjct: 184 KADTKSGLWFTV--LEHYHRTSCIVSDLIIGNSYAFRVFAENQCGLSE 229
Score = 49.2 bits (112), Expect = 2e-04
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 1/97 (1%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVA 566
S AP F + L T G Q C V PRP+I W + I+ + ++ +
Sbjct: 258 SEAPKFTQPLADCTTVTGYNTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRA-LTHLGIC 316
Query: 567 TLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+L IR+ P D G +TC A N G AS + V+ P
Sbjct: 317 SLEIRKPGPFDGGIYTCKAVNPLGEASVDCRVDVKVP 353
Score = 45.6 bits (103), Expect = 0.002
Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 11/134 (8%)
Query: 1932 EKDEIIFRISAENTVGVSLPTESQSVRLEKHATV-------PSPPTAPLEIRMVGSNIVM 1984
E+D I+F A+ Q LE AT+ P PP + + + G + +
Sbjct: 105 EQDSILFIREAQRADSGRYQLRVQLGGLEATATIDILVIERPGPPQSIKLVDVWGFSATL 164
Query: 1985 TSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYAR 2044
W P+ G LLGY + D +W V + + + DL ++Y R++A
Sbjct: 165 -EWTPPQDTGNTALLGYTVQKADTKSGLWFTVLE-HYHRTSCIVSDLIIGNSYAFRVFAE 222
Query: 2045 NEIGLSE--PLESD 2056
N+ GLSE P+ +D
Sbjct: 223 NQCGLSETAPITTD 236
Score = 45.2 bits (102), Expect = 0.003
Identities = 33/97 (34%), Positives = 43/97 (44%), Gaps = 6/97 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH----S 788
E P+ +PL G + L V +PRP I W KN ++ P K TH S
Sbjct: 259 EAPKFTQPLADCTTVTGYNTQLFCCVRASPRPKIIWLKNKMDIQGNP-KYRALTHLGICS 317
Query: 789 ITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEP 825
+ I KP D G+YT KA N G A + V+ P
Sbjct: 318 LEIRKPGPF-DGGIYTCKAVNPLGEASVDCRVDVKVP 353
Score = 41.5 bits (93), Expect = 0.032
Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 7/104 (6%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE- 1924
P P++ + + S TL+WT P+ G + + Y ++ K W TV H
Sbjct: 146 PGPPQSIKLVDVWGFSATLEWTPPQDTGNTALLGYTVQKADTKSGLW---FTVLEHYHRT 202
Query: 1925 HCI-ENIKEKDEIIFRISAENTVGVS--LPTESQSVRLEKHATV 1965
CI ++ + FR+ AEN G+S P + ++K ATV
Sbjct: 203 SCIVSDLIIGNSYAFRVFAENQCGLSETAPITTDLAHIQKAATV 246
Score = 33.9 bits (74), Expect = 6.4
Identities = 17/67 (25%), Positives = 31/67 (46%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ P P++IW KN ++ + +Y T + I++ YT +A N G +S
Sbjct: 284 VRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCKAVNPLGEAS 343
Query: 1656 VEVTLKV 1662
V+ + V
Sbjct: 344 VDCRVDV 350
>AB037663-1|BAB21504.1| 992|Homo sapiens myosin light chain kinase
protein.
Length = 992
Score = 96.3 bits (229), Expect = 1e-18
Identities = 53/200 (26%), Positives = 90/200 (45%), Gaps = 1/200 (0%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP+I+ + + +++ G V L W+ K I++ +H K + LT
Sbjct: 315 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLT 374
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDEPE 1405
I G Y L +EN G ++N+T++DKP PP G P +I SSS+ + W
Sbjct: 375 ILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 434
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G S + Y +E + W + T ++Q+L + Y+FR A+N S+ S
Sbjct: 435 YDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPS 494
Query: 1466 ETTEYYKVIKETKIQSPTVE 1485
+ +E V ++ + VE
Sbjct: 495 QESELTTVGEKPEEPKDEVE 514
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 862 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 921
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 922 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 978
Score = 81.4 bits (192), Expect = 3e-14
Identities = 51/176 (28%), Positives = 79/176 (44%), Gaps = 3/176 (1%)
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
QK + G+ + + G P W K +++ + + E S + I ++ H
Sbjct: 325 QKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCG 384
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
YT+ N G+ +V L V DKP P G +I S+T+ W DGG + Y
Sbjct: 385 CYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 444
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESE 1756
+IE + N W ++A ++ +Q L + EY FRV A N G SE + ESE
Sbjct: 445 SIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 498
Score = 66.5 bits (155), Expect = 1e-09
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE Q AP F +KL+ H +G + +CQV P I W +K ++ F + +
Sbjct: 169 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQE 227
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDH 607
++ ++ I + PED G + CVAKN AG A + ++ V +AP S++
Sbjct: 228 GSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASEN 273
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/200 (24%), Positives = 87/200 (43%), Gaps = 12/200 (6%)
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
+KV + + + + E+C + ++ +N +G +A V T +D P
Sbjct: 362 MKVENSENGSKLTILAARQEHCG-CYTLLVENKLGSRQAQ-----VNLTVVDKPDPPAGT 415
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSIN 1832
I + S+ ++W+ S +GGS + Y +EI K WK +Q L +
Sbjct: 416 PCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD 475
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTSRSVTLKWTEPES 1891
Y+FR+ A N GTS P + T+G+ P +P++ V VS+ + + +
Sbjct: 476 HEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPKDEVEVSDDDEKEPEVDYRTVTI 532
Query: 1892 NGGSPITN-YIIEFKTVKGK 1910
N +++ Y IE + GK
Sbjct: 533 NTEQKVSDFYDIEERLGSGK 552
Score = 58.0 bits (134), Expect = 3e-07
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 409 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 466
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
FN++DL +H Y R+ A N G SEP + E V GE EEP ++ EV
Sbjct: 467 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTV--GE---KPEEPKDEVEV 515
Score = 56.0 bits (129), Expect = 1e-06
Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 5/132 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + L+ + V +G+ ++L QV +P TI W N K +K + +G S++I
Sbjct: 176 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 235
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTI 850
K +D G+Y A+N G AE S +TV++ P EN + P +R + ++
Sbjct: 236 EKALP-EDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGT 294
Query: 851 KLVARVTRNPVP 862
+ A V + P P
Sbjct: 295 ESDATVKKKPAP 306
Score = 55.2 bits (127), Expect = 2e-06
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 43/246 (17%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI--------- 680
+G P F +K + +V EG +LL+C++ + P I W G+ + + I
Sbjct: 172 QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLC 231
Query: 681 SVAIES----DMHMY------------CSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
SV+IE D +Y CS + E T +R ++SLP V
Sbjct: 232 SVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPV 291
Query: 725 L--------KIKTGEKEPP------QVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK 770
L K K K PP Q+I+ + VR GESV L +V G T TW K
Sbjct: 292 LGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMK 351
Query: 771 NNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
K ++ + ++ + +TIL ++ + G YTL EN G + +TV + +
Sbjct: 352 FRKQIQESEHMKVENSENGSKLTILAARQ-EHCGCYTLLVENKLGSRQAQVNLTVVDKPD 410
Query: 828 ENAEPP 833
A P
Sbjct: 411 PPAGTP 416
Score = 54.0 bits (124), Expect = 6e-06
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E+ +E P F + Q++ V E + L +V+ +P +I W N + + ++ I +
Sbjct: 166 EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILS 225
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
+G + I E D G YKCVA N AG++ +VT+D
Sbjct: 226 QEGSLCSVSIEKALPE-DRGLYKCVAKNDAGQAECSCQVTVD 266
Score = 52.8 bits (121), Expect = 1e-05
Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P F +KLQD V E +L+ +++S+ A ++W +G+ +K K + G +
Sbjct: 174 TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQEGSLCS 232
Query: 1074 LYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
+ I D G Y C+ ++++ C+ +VTV + P T+ K + + +
Sbjct: 233 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVL 292
Query: 1130 LTKGDALVR 1138
T+ DA V+
Sbjct: 293 GTESDATVK 301
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 885 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 942
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 943 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 982
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+NLK+ S + N+V+ T + E++ +P ++ L+++ + +
Sbjct: 135 ENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLL 194
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX----XXXYKCIAFNDH 1556
L C P + W +GK LKT K ++ YKC+A ND
Sbjct: 195 LQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDA 254
Query: 1557 GEVETSCVVGIQQKP 1571
G+ E SC V + P
Sbjct: 255 GQAECSCQVTVDDAP 269
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 859 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 918
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 919 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 977
Query: 924 D 924
+
Sbjct: 978 E 978
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 4/101 (3%)
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKD 1934
S+ S S+TL W +GGS + +Y IE K+W ++ T + ++++
Sbjct: 419 SDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFN--VQDLLPDH 476
Query: 1935 EIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
E FR+ A N G S P SQ L P P +E+
Sbjct: 477 EYKFRVRAINVYGTSEP--SQESELTTVGEKPEEPKDEVEV 515
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/88 (26%), Positives = 40/88 (45%)
Query: 1295 REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
++ + G + L + P W +N K +K K S + S++I+K D
Sbjct: 183 QDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPED 242
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPS 1382
G+YK +N+ G A+ VT+ D P+
Sbjct: 243 RGLYKCVAKNDAGQAECSCQVTVDDAPA 270
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 887 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 946
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 947 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 978
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 910 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 969
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 970 TCTAELIV 977
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 887 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 946
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 947 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 986
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/103 (22%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +LQ+ V +G K + +++ A + W +G ++ + I L+ +G + I
Sbjct: 176 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 235
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
+D G Y C + G ++C+ +TV++ + + PE
Sbjct: 236 EKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 278
Score = 33.9 bits (74), Expect = 6.4
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + PP +IW NG L+ K ++ + + I++ Y
Sbjct: 190 GKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCV 249
Query: 1647 ASNTAGTSSVEVTLKVYDKPS 1667
A N AG + + V D P+
Sbjct: 250 AKNDAGQAECSCQVTVDDAPA 270
Score = 33.5 bits (73), Expect = 8.5
Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 12/128 (9%)
Query: 1105 LPPEIITRLQNQKVNKGNKATFEIELTKGDALV-RWFKDGSEIQFSNHIQLTIDGKKQKL 1163
+PP+II ++QKV G ++T + W K +IQ S H+++ KL
Sbjct: 314 MPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKL 373
Query: 1164 KIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFT-LRLPEFILVPANTDAYLTVEIPD 1222
I + G Y+ V N L + +N T + P+ PA T +I
Sbjct: 374 TILAARQEHCGCYTLLVENK-----LGSRQAQVNLTVVDKPD---PPAGTPC--ASDIRS 423
Query: 1223 ETLDVTWY 1230
+L ++WY
Sbjct: 424 SSLTLSWY 431
>BC115022-1|AAI15023.1| 1551|Homo sapiens ROBO1 protein protein.
Length = 1551
Score = 95.9 bits (228), Expect = 1e-18
Identities = 79/327 (24%), Positives = 135/327 (41%), Gaps = 22/327 (6%)
Query: 605 SDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPD 664
SD G + V A++ P+F K+P V +C P P
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 253
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
+ W K + +P + D H LKI V G+YT VA N G+A
Sbjct: 254 VRWR-KDDGELPKSRYEIR---DDH----TLKIRKVTAGDMGSYTCVAENMVGKAEASAT 305
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN--------KPVK 776
L ++ G + P V++P + +V G +V + GNP+P I W + +P +
Sbjct: 306 LTVQVGSEPPHFVVKP-RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 364
Query: 777 ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFI 836
+ S T +TI ++ D G Y + N G T A + V + + PP+
Sbjct: 365 SSSRFSVSQTGDLTITNVQR-SDVGYYICQTLNVAGSIITKAYLEVTDVIADR-PPPVIR 422
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
TV GT L T +PVP+I W ++ ++S ++ + + +++ +
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTI 923
D+G Y C+AS +G+++ A + +
Sbjct: 483 ---DTGRYTCIASTPSGEATWSAYIEV 506
Score = 91.1 bits (216), Expect = 4e-17
Identities = 102/397 (25%), Positives = 163/397 (41%), Gaps = 46/397 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P FV++ + +F+C+ G P P + W + + P +++ DD+ TL
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR--DDH--TLK 277
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
IR+V D G++TCVA+N G A ++ L V+ GSE
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----GSE------------------- 313
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
PP F KP+ Q V G + +C P+P I W +G + + S
Sbjct: 314 ---PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 690 M-YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT--GEKEPPQVIEPLKSMIV 746
+ L ITNV++ G Y +N G L++ ++ PP + + + V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ +LS G+P PTI W K+ V ++ + + ++ K+ D G YT
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490
Query: 807 AENSEGIAETSAVITVEEPTEENAEP-PLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A G A SA I V+E P P N K + V V+RN V +++
Sbjct: 491 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPE-----VTDVSRNTV-TLS 544
Query: 866 WYRN-NEIISPSETITQNF---DGENIELVITNVDSE 898
W N N +P+ I + F G + + V NV +E
Sbjct: 545 WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE 581
Score = 80.6 bits (190), Expect = 6e-14
Identities = 111/486 (22%), Positives = 181/486 (37%), Gaps = 45/486 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E PP + P V +G L C+ P P I W GE + D++ + +
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 690 M-YCSVLKITNVKKFQ--EGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMI 745
L+I + +K + EG Y VA N GEA S L++ + Q P M+
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ--NPSDVMV 142
Query: 746 VRQGESVILSAQVV-GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYT 804
V GE ++ Q G+P PTI+W K+ P+ + + I +K D G Y
Sbjct: 143 V-VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK-SDAGKYV 200
Query: 805 LKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
N G E+ A +TV E P F+ R + V + + +PVP+
Sbjct: 201 CVGTNMVGERESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 253
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ W +++ + S ++ I V D G Y CVA N GK+ A +T+
Sbjct: 254 VRWRKDDGELPKSRYEIRDDHTLKIRKVTAG-----DMGSYTCVAENMVGKAEASATLTV 308
Query: 924 DV--EKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGM-------DHRE 974
V E FV + G+TV +C+ + + ++ +
Sbjct: 309 QVGSEPPHFVVK-PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 367
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETSTMLVVKETI----PEFIRK--LQ 1024
+ DVG C + T L V + I P IR+ +
Sbjct: 368 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
Query: 1025 DFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ + V S ++W +DG ++ + ++ + G L IR + D
Sbjct: 428 QTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG---VLQIRYAKLGDT 484
Query: 1085 GEYSCI 1090
G Y+CI
Sbjct: 485 GRYTCI 490
Score = 77.8 bits (183), Expect = 4e-13
Identities = 106/460 (23%), Positives = 183/460 (39%), Gaps = 49/460 (10%)
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM-NVTILDKPSPPGKPNILEI--DS 1394
I + L I +DAG Y N G + E+ +T+L++PS +P+ L + D
Sbjct: 179 ITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD 238
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRA 1453
S+ C E G+ V +++ D S I T I+ + +
Sbjct: 239 SAEFKC----EARGDPVP---TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
A N V ++AS T ++ V KP + + C G PQP +
Sbjct: 292 VAENMVGKAEASATL----TVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAI 346
Query: 1514 TWYRDGKK---------LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV 1564
W R+G + +++ + Y C N G + T
Sbjct: 347 FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAY 406
Query: 1565 VG----IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
+ I +P I + Q V ++++ V G P P ++W K+G L + ++
Sbjct: 407 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLVSTQDSR 465
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD-----KPSKPEGPVI- 1674
I E V++I+ K + +YT AS +G ++ ++V + +P +P P +
Sbjct: 466 IKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524
Query: 1675 --------MREISRESVTIEWKPPLDDGGLELTKYAIEK-HEPDNNRWIKVADVDRDVET 1725
+ ++SR +VT+ W+P L+ G T Y IE + W VA+ + ET
Sbjct: 525 PSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-TSYIIEAFSHASGSSWQTVAE-NVKTET 582
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTAL 1764
I+ L N Y+F V A N G S+ + S+P+ + L
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVL 622
Score = 72.9 bits (171), Expect = 1e-11
Identities = 110/423 (26%), Positives = 168/423 (39%), Gaps = 61/423 (14%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQD----FQMYY 560
++ P VE G C+ EG P P I W++ ++ +D +M
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 561 DDDNVATLVI---REVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXX 617
++ L I R+ P D G + CVA+N G A S + A L D +
Sbjct: 84 PSGSLFFLRIVHGRKSRP-DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ----NPS 138
Query: 618 XXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPD 677
++E PP +P + +GS + + D +G +++
Sbjct: 139 DVMVVVGEPAVMECQPPRGHPEPTISWKKDGS---------PLDDKDERITIRGGKLM-- 187
Query: 678 ENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV 737
I+ +SD Y V GT V RE E + VL+ + K P
Sbjct: 188 --ITYTRKSDAGKYVCV-----------GTNMV--GERESEVAELTVLERPSFVKRP--- 229
Query: 738 IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV 797
++ V +S + G+P PT+ W K++ LP KS + LK +KV
Sbjct: 230 ----SNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---GELP-KSRYEIRDDHTLKIRKV 281
Query: 798 K--DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVAR 855
D G YT AEN G AE SA +TV + +EPP F+ + ++ V T+
Sbjct: 282 TAGDMGSYTCVAENMVGKAEASATLTV----QVGSEPPHFVVKPRDQVVALGRTVTFQCE 337
Query: 856 VTRNPVPSITWYR---NNEIIS--PSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
T NP P+I W R N + S P ++ ++ + +L ITNV D G Y C N
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGYYICQTLN 396
Query: 911 SAG 913
AG
Sbjct: 397 VAG 399
Score = 72.5 bits (170), Expect = 1e-11
Identities = 99/400 (24%), Positives = 156/400 (39%), Gaps = 42/400 (10%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKR----GHI 1071
P + D V + + A L + T + W + GE ++ K+ + G +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 1072 RKLYIRN--TSVHDEGEYSCILRDE-----SCTAEVTVVELPPEIITRLQNQKVNKGNKA 1124
L I + S DEG Y C+ R+ S A + V L + + V G A
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVVVGEPA 148
Query: 1125 TFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
E + +G + + W KDGS + + ++TI G K L I DAG+Y C N
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGK--LMITYTRKSDAGKYVCVGTN 205
Query: 1183 ------SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVI 1236
S+ + +E PS ++ P + V + A E + + ++K
Sbjct: 206 MVGERESEVAELTVLERPSF---VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVD 1292
++ + D TL IRK T D YTCV + A+++ L V+V PP V
Sbjct: 263 LPKSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 1293 YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK-----SASLTI 1347
R+ + G VT + PQP W + P S+ + LTI
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 1348 KKVENTDAGIYKLRLENNCG----HADVEMNVTILDKPSP 1383
V+ +D G Y + N G A +E+ I D+P P
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 419
Score = 70.5 bits (165), Expect = 6e-11
Identities = 127/628 (20%), Positives = 229/628 (36%), Gaps = 53/628 (8%)
Query: 1275 STTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHT 1334
S ++L+ E +FPP+IV++ + + +G TL + P P EW + ++ K
Sbjct: 18 SGSRLRQE--DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDD 75
Query: 1335 KPS--IDSKSASLTIKKV-----ENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPP 1384
S + S SL ++ D G+Y N G A + + V IL
Sbjct: 76 PRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ 135
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLK 1444
+++ + + P TI + D E I+++ + I +
Sbjct: 136 NPSDVMVVVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTR 192
Query: 1445 TNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCI 1504
+ + ++ N V + SE E T ++ P+ K N+ ++ E C
Sbjct: 193 KSDAGKYVCVGTNMVGERE-SEVAEL------TVLERPSFVKRPSNLAVTVDDSAEFKCE 245
Query: 1505 FGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV 1564
G P P V W +D +L ++ + Y C+A N G+ E S
Sbjct: 246 ARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASAT 305
Query: 1565 VGIQ---QKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK-----LEND 1616
+ +Q + P + D Q +G G P P + W + G++ +
Sbjct: 306 LTVQVGSEPPHFVVKPRD--QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR 1676
+ + + +T + I ++RS Y + N AG+ + L+V D + PVI +
Sbjct: 364 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ 423
Query: 1677 EISRESVTIEWKPPLD---DGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNE 1733
++V ++ L G T + + + ++ ++ V KL +
Sbjct: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 483
Query: 1734 NCEYMFRVIAQNPVG---FSEALESE----PIVIKTALD---VPSXXXXXXXXXXIDNES 1783
Y IA P G +S +E + P+ D +PS + +
Sbjct: 484 TGRY--TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS-APSKPEVTDVSRNT 540
Query: 1784 VYITWFPSEKNGGSPIIDYKVEI--KQEGKKWKX-XXXXXXXXARIQKLSINTTYQFRIY 1840
V ++W P+ +G +P Y +E G W+ + I+ L N Y F +
Sbjct: 541 VTLSWQPNLNSGATP-TSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVR 599
Query: 1841 ARNEIGTSLPYTSDDKITIGKTLTPPSQ 1868
A N G S P D + L P SQ
Sbjct: 600 AANAYGISDPSQISDPVKTQDVL-PTSQ 626
Score = 65.3 bits (152), Expect = 2e-09
Identities = 116/535 (21%), Positives = 201/535 (37%), Gaps = 50/535 (9%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT 790
E PP+++E +IV +GE L+ + G P PTI W K + V+ K D +H +
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET--DKDDPRSHRML 82
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINR--FQE-----IT 843
+ V+ K+ EG+ A + E NA + I R F++ +
Sbjct: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
Query: 844 VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
V + + +P P+I+W ++ SP + + +L+IT + D+G
Sbjct: 143 VVGEPAVMECQPPRGHPEPTISWKKDG---SPLDDKDERITIRGGKLMIT-YTRKSDAGK 198
Query: 904 YKCVASNSAG-KSSHGARVTIDVEKVTFVKHLQK-SYETEEGKTVILECQTSHTVSTKWY 961
Y CV +N G + S A +T+ +E+ +FVK + ++ E + + +W
Sbjct: 199 YVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 962 HNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVVK--ET 1015
+ E+ EI + D+G C+ ++ E S L V+
Sbjct: 258 KDDGELP-KSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSE 313
Query: 1016 IPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGE-----IIKPKKNKYDFEKRG 1069
P F+ K +D V + E + W R+G +P ++ F
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV-S 372
Query: 1070 HIRKLYIRNTSVHDEGEYSCILRD------ESCTAEVT--VVELPPEIITR-LQNQKVNK 1120
L I N D G Y C + EVT + + PP +I + NQ V
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
Query: 1121 GNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC- 1178
T + W KDG + S + L+I L D G Y+C
Sbjct: 433 DGTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490
Query: 1179 ---EVGNSKCTAILTVEEPSINFTLRLP-EFILVPANTDAYLTVEIPDETLDVTW 1229
G + +A + V+E + P + L+P+ ++ T+ ++W
Sbjct: 491 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
Score = 48.8 bits (111), Expect = 2e-04
Identities = 62/246 (25%), Positives = 93/246 (37%), Gaps = 38/246 (15%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA-----IIKPSQDF 556
T + S P FV K R + G TV F+C+ G P+P I W R+ + +P Q
Sbjct: 307 TVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS- 365
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXX 616
+ L I V D G + C N AG +I +A L E+T
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG------SIITKAYL-----EVTDV-- 412
Query: 617 XXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP 676
I + PP + P Q V +L C P P I W G +
Sbjct: 413 -----------IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST 461
Query: 677 DENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT--GEKEP 734
++ +E+ VL+I K G YT +A GEA+ ++++ +P
Sbjct: 462 QDSRIKQLEN------GVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
Query: 735 PQVIEP 740
P+ +P
Sbjct: 516 PRPTDP 521
Score = 48.8 bits (111), Expect = 2e-04
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSVHE 1924
PS P V++ + +VTL W +P N G+ T+YIIE F G SW + V
Sbjct: 525 PSAPSKPEVTDVSRNTVTLSW-QPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTET 582
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE 1953
I+ +K +F + A N G+S P++
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQ 611
Score = 46.8 bits (106), Expect = 9e-04
Identities = 31/97 (31%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 1965 VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTMWMEVGKVDVNT 2023
+PS P+ P E+ V N V SW P + GA Y I A + + W V + +V T
Sbjct: 524 IPSAPSKP-EVTDVSRNTVTLSW-QPNLNSGATPTSYIIEAFSHASGSSWQTVAE-NVKT 580
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
I+ L N Y+ + A N G+S+P + +P K
Sbjct: 581 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
>BC115020-1|AAI15021.1| 1606|Homo sapiens ROBO1 protein protein.
Length = 1606
Score = 95.9 bits (228), Expect = 1e-18
Identities = 79/327 (24%), Positives = 135/327 (41%), Gaps = 22/327 (6%)
Query: 605 SDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPD 664
SD G + V A++ P+F K+P V +C P P
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 253
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
+ W K + +P + D H LKI V G+YT VA N G+A
Sbjct: 254 VRWR-KDDGELPKSRYEIR---DDH----TLKIRKVTAGDMGSYTCVAENMVGKAEASAT 305
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN--------KPVK 776
L ++ G + P V++P + +V G +V + GNP+P I W + +P +
Sbjct: 306 LTVQVGSEPPHFVVKP-RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 364
Query: 777 ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFI 836
+ S T +TI ++ D G Y + N G T A + V + + PP+
Sbjct: 365 SSSRFSVSQTGDLTITNVQR-SDVGYYICQTLNVAGSIITKAYLEVTDVIADR-PPPVIR 422
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
TV GT L T +PVP+I W ++ ++S ++ + + +++ +
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTI 923
D+G Y C+AS +G+++ A + +
Sbjct: 483 ---DTGRYTCIASTPSGEATWSAYIEV 506
Score = 91.1 bits (216), Expect = 4e-17
Identities = 102/397 (25%), Positives = 163/397 (41%), Gaps = 46/397 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P FV++ + +F+C+ G P P + W + + P +++ DD+ TL
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR--DDH--TLK 277
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
IR+V D G++TCVA+N G A ++ L V+ GSE
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----GSE------------------- 313
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
PP F KP+ Q V G + +C P+P I W +G + + S
Sbjct: 314 ---PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 690 M-YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT--GEKEPPQVIEPLKSMIV 746
+ L ITNV++ G Y +N G L++ ++ PP + + + V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ +LS G+P PTI W K+ V ++ + + ++ K+ D G YT
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490
Query: 807 AENSEGIAETSAVITVEEPTEENAEP-PLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A G A SA I V+E P P N K + V V+RN V +++
Sbjct: 491 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPE-----VTDVSRNTV-TLS 544
Query: 866 WYRN-NEIISPSETITQNF---DGENIELVITNVDSE 898
W N N +P+ I + F G + + V NV +E
Sbjct: 545 WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE 581
Score = 79.8 bits (188), Expect = 1e-13
Identities = 110/486 (22%), Positives = 181/486 (37%), Gaps = 45/486 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E PP + P V +G L C+ P P I W GE + D++ + +
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 690 M-YCSVLKITNVKKFQ--EGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMI 745
L+I + +K + EG Y VA N GEA S L++ + Q P ++
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ--NP-SDVM 141
Query: 746 VRQGESVILSAQVV-GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYT 804
V GE ++ Q G+P PTI+W K+ P+ + + I +K D G Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK-SDAGKYV 200
Query: 805 LKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
N G E+ A +TV E P F+ R + V + + +PVP+
Sbjct: 201 CVGTNMVGERESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 253
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ W +++ + S ++ I V D G Y CVA N GK+ A +T+
Sbjct: 254 VRWRKDDGELPKSRYEIRDDHTLKIRKVTAG-----DMGSYTCVAENMVGKAEASATLTV 308
Query: 924 DV--EKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGM-------DHRE 974
V E FV + G+TV +C+ + + ++ +
Sbjct: 309 QVGSEPPHFVVK-PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 367
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETSTMLVVKETI----PEFIRK--LQ 1024
+ DVG C + T L V + I P IR+ +
Sbjct: 368 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
Query: 1025 DFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ + V S ++W +DG ++ + ++ + G L IR + D
Sbjct: 428 QTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG---VLQIRYAKLGDT 484
Query: 1085 GEYSCI 1090
G Y+CI
Sbjct: 485 GRYTCI 490
Score = 77.8 bits (183), Expect = 4e-13
Identities = 106/460 (23%), Positives = 183/460 (39%), Gaps = 49/460 (10%)
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM-NVTILDKPSPPGKPNILEI--DS 1394
I + L I +DAG Y N G + E+ +T+L++PS +P+ L + D
Sbjct: 179 ITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD 238
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRA 1453
S+ C E G+ V +++ D S I T I+ + +
Sbjct: 239 SAEFKC----EARGDPVP---TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
A N V ++AS T ++ V KP + + C G PQP +
Sbjct: 292 VAENMVGKAEASATL----TVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAI 346
Query: 1514 TWYRDGKK---------LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV 1564
W R+G + +++ + Y C N G + T
Sbjct: 347 FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAY 406
Query: 1565 VG----IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
+ I +P I + Q V ++++ V G P P ++W K+G L + ++
Sbjct: 407 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLVSTQDSR 465
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD-----KPSKPEGPVI- 1674
I E V++I+ K + +YT AS +G ++ ++V + +P +P P +
Sbjct: 466 IKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524
Query: 1675 --------MREISRESVTIEWKPPLDDGGLELTKYAIEK-HEPDNNRWIKVADVDRDVET 1725
+ ++SR +VT+ W+P L+ G T Y IE + W VA+ + ET
Sbjct: 525 PSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-TSYIIEAFSHASGSSWQTVAE-NVKTET 582
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTAL 1764
I+ L N Y+F V A N G S+ + S+P+ + L
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVL 622
Score = 73.3 bits (172), Expect = 9e-12
Identities = 110/423 (26%), Positives = 168/423 (39%), Gaps = 61/423 (14%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQD----FQMYY 560
++ P VE G C+ EG P P I W++ ++ +D +M
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 561 DDDNVATLVI---REVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXX 617
++ L I R+ P D G + CVA+N G A S + A L D +
Sbjct: 84 PSGSLFFLRIVHGRKSRP-DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ----NPS 138
Query: 618 XXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPD 677
++E PP +P + +GS + + D +G +++
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGS---------PLDDKDERITIRGGKLM-- 187
Query: 678 ENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV 737
I+ +SD Y V GT V RE E + VL+ + K P
Sbjct: 188 --ITYTRKSDAGKYVCV-----------GTNMV--GERESEVAELTVLERPSFVKRP--- 229
Query: 738 IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV 797
++ V +S + G+P PT+ W K++ LP KS + LK +KV
Sbjct: 230 ----SNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---GELP-KSRYEIRDDHTLKIRKV 281
Query: 798 K--DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVAR 855
D G YT AEN G AE SA +TV + +EPP F+ + ++ V T+
Sbjct: 282 TAGDMGSYTCVAENMVGKAEASATLTV----QVGSEPPHFVVKPRDQVVALGRTVTFQCE 337
Query: 856 VTRNPVPSITWYR---NNEIIS--PSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
T NP P+I W R N + S P ++ ++ + +L ITNV D G Y C N
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGYYICQTLN 396
Query: 911 SAG 913
AG
Sbjct: 397 VAG 399
Score = 72.9 bits (171), Expect = 1e-11
Identities = 99/400 (24%), Positives = 156/400 (39%), Gaps = 42/400 (10%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKR----GHI 1071
P + D V + + A L + T + W + GE ++ K+ + G +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 1072 RKLYIRN--TSVHDEGEYSCILRDE-----SCTAEVTVVELPPEIITRLQNQKVNKGNKA 1124
L I + S DEG Y C+ R+ S A + V L + + V G A
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 1125 TFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
E + +G + + W KDGS + + ++TI G K L I DAG+Y C N
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGK--LMITYTRKSDAGKYVCVGTN 205
Query: 1183 ------SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVI 1236
S+ + +E PS ++ P + V + A E + + ++K
Sbjct: 206 MVGERESEVAELTVLERPSF---VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVD 1292
++ + D TL IRK T D YTCV + A+++ L V+V PP V
Sbjct: 263 LPKSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 1293 YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK-----SASLTI 1347
R+ + G VT + PQP W + P S+ + LTI
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 1348 KKVENTDAGIYKLRLENNCG----HADVEMNVTILDKPSP 1383
V+ +D G Y + N G A +E+ I D+P P
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 419
Score = 64.9 bits (151), Expect = 3e-09
Identities = 121/540 (22%), Positives = 206/540 (38%), Gaps = 60/540 (11%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH--- 787
E PP+++E +IV +GE L+ + G P PTI W K + V+ K D +H
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET--DKDDPRSHRML 82
Query: 788 ----SITILK----PKKVKDEGVYTLKAENSEGIAET-SAVITVEEPTEENAEPPLFINR 838
S+ L+ K DEGVY A N G A + +A + V ++ + P +
Sbjct: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-- 140
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSE 898
+ V E ++ +P P+I+W ++ SP + + +L+IT +
Sbjct: 141 --MVAVGEPAVME-CQPPRGHPEPTISWKKDG---SPLDDKDERITIRGGKLMIT-YTRK 193
Query: 899 IDSGDYKCVASNSAG-KSSHGARVTIDVEKVTFVKHLQK-SYETEEGKTVILECQTSHTV 956
D+G Y CV +N G + S A +T+ +E+ +FVK + ++ E +
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 957 STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVV 1012
+ +W + E+ EI + D+G C+ ++ E S L V
Sbjct: 253 TVRWRKDDGELP-KSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 1013 K--ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGE-----IIKPKKNKYD 1064
+ P F+ K +D V + E + W R+G +P ++
Sbjct: 309 QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 368
Query: 1065 FEKRGHIRKLYIRNTSVHDEGEYSCILRD------ESCTAEVT--VVELPPEIITR-LQN 1115
F L I N D G Y C + EVT + + PP +I + N
Sbjct: 369 FSV-SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
Query: 1116 QKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAG 1174
Q V T + W KDG + S + L+I L D G
Sbjct: 428 QTVAVDGTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 1175 EYSC----EVGNSKCTAILTVEEPSINFTLRLP-EFILVPANTDAYLTVEIPDETLDVTW 1229
Y+C G + +A + V+E + P + L+P+ ++ T+ ++W
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
Score = 55.6 bits (128), Expect = 2e-06
Identities = 110/505 (21%), Positives = 192/505 (38%), Gaps = 61/505 (12%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS-----NHIQLTID 1157
+ PP I+ + V+KG AT + + + W+K G ++ +H L
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 1158 GKKQKLKIYDC--DLDDAGEYSCEVGNSKCTAI---LTVEEPSINFTLRL-PEFILVPAN 1211
G L+I D G Y C N A+ ++E + R P ++V
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 1212 TDAYLTVEIPDETLD--VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
A + + P + ++W K S ++D ++ I K L+I + D +Y CV
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK---LMITYTRKSDAGKYVCV 202
Query: 1270 LLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--------PQPNDEW 1321
+ + EV E + ER +KR S++ + VD A P P W
Sbjct: 203 --GTNMVGERESEVAE----LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K ++ +L I+KV D G Y EN G A+ +T+
Sbjct: 257 RKDDGELPKSRYEIRD----DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 1382 SPPG---KPNILEIDSSSINICWDEPENTGN-STIIYY--------VVEYQEIDTTEWIS 1429
PP KP ++ + + + + E TGN I++ + YQ ++ S
Sbjct: 313 EPPHFVVKPRD-QVVALGRTVTF-QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 1430 VKNI-TKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EK 1486
V T T++Q +++ Y Y ++++ + T Y +V + P V +
Sbjct: 371 VSQTGDLTITNVQ--RSDVGY----YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424
Query: 1487 PLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXX 1544
P+ N T + L+C+ G P P + W +DG + T + +
Sbjct: 425 PV-NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 483
Query: 1545 XXXYKCIAFNDHGEVETSCVVGIQQ 1569
Y CIA GE S + +Q+
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQE 508
Score = 48.8 bits (111), Expect = 2e-04
Identities = 62/246 (25%), Positives = 93/246 (37%), Gaps = 38/246 (15%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA-----IIKPSQDF 556
T + S P FV K R + G TV F+C+ G P+P I W R+ + +P Q
Sbjct: 307 TVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS- 365
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXX 616
+ L I V D G + C N AG +I +A L E+T
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG------SIITKAYL-----EVTDV-- 412
Query: 617 XXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP 676
I + PP + P Q V +L C P P I W G +
Sbjct: 413 -----------IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST 461
Query: 677 DENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT--GEKEP 734
++ +E+ VL+I K G YT +A GEA+ ++++ +P
Sbjct: 462 QDSRIKQLEN------GVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
Query: 735 PQVIEP 740
P+ +P
Sbjct: 516 PRPTDP 521
Score = 48.8 bits (111), Expect = 2e-04
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSVHE 1924
PS P V++ + +VTL W +P N G+ T+YIIE F G SW + V
Sbjct: 525 PSAPSKPEVTDVSRNTVTLSW-QPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTET 582
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE 1953
I+ +K +F + A N G+S P++
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQ 611
Score = 46.8 bits (106), Expect = 9e-04
Identities = 31/97 (31%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 1965 VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTMWMEVGKVDVNT 2023
+PS P+ P E+ V N V SW P + GA Y I A + + W V + +V T
Sbjct: 524 IPSAPSKP-EVTDVSRNTVTLSW-QPNLNSGATPTSYIIEAFSHASGSSWQTVAE-NVKT 580
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
I+ L N Y+ + A N G+S+P + +P K
Sbjct: 581 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Score = 38.7 bits (86), Expect = 0.23
Identities = 36/159 (22%), Positives = 58/159 (36%), Gaps = 10/159 (6%)
Query: 1507 GVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV 1564
G P+P ++W +DG L K + T Y C+ N GE E+
Sbjct: 157 GHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 1565 -VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITT 1623
+ + ++P ++ V D G P P V W K+ +L + Y I
Sbjct: 216 ELTVLERPSFVKRPSNLAV--TVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEI-- 270
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++I+++ YT A N G + TL V
Sbjct: 271 -RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
>BC112336-1|AAI12337.1| 1607|Homo sapiens ROBO1 protein protein.
Length = 1607
Score = 95.9 bits (228), Expect = 1e-18
Identities = 79/327 (24%), Positives = 135/327 (41%), Gaps = 22/327 (6%)
Query: 605 SDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPD 664
SD G + V A++ P+F K+P V +C P P
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 253
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
+ W K + +P + D H LKI V G+YT VA N G+A
Sbjct: 254 VRWR-KDDGELPKSRYEIR---DDH----TLKIRKVTAGDMGSYTCVAENMVGKAEASAT 305
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN--------KPVK 776
L ++ G + P V++P + +V G +V + GNP+P I W + +P +
Sbjct: 306 LTVQVGSEPPHFVVKP-RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 364
Query: 777 ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFI 836
+ S T +TI ++ D G Y + N G T A + V + + PP+
Sbjct: 365 SSSRFSVSQTGDLTITNVQR-SDVGYYICQTLNVAGSIITKAYLEVTDVIADR-PPPVIR 422
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
TV GT L T +PVP+I W ++ ++S ++ + + +++ +
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTI 923
D+G Y C+AS +G+++ A + +
Sbjct: 483 ---DTGRYTCIASTPSGEATWSAYIEV 506
Score = 91.1 bits (216), Expect = 4e-17
Identities = 102/397 (25%), Positives = 163/397 (41%), Gaps = 46/397 (11%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P FV++ + +F+C+ G P P + W + + P +++ DD+ TL
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR--DDH--TLK 277
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
IR+V D G++TCVA+N G A ++ L V+ GSE
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----GSE------------------- 313
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
PP F KP+ Q V G + +C P+P I W +G + + S
Sbjct: 314 ---PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 690 M-YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT--GEKEPPQVIEPLKSMIV 746
+ L ITNV++ G Y +N G L++ ++ PP + + + V
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 747 RQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLK 806
+ +LS G+P PTI W K+ V ++ + + ++ K+ D G YT
Sbjct: 431 AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490
Query: 807 AENSEGIAETSAVITVEEPTEENAEP-PLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
A G A SA I V+E P P N K + V V+RN V +++
Sbjct: 491 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPE-----VTDVSRNTV-TLS 544
Query: 866 WYRN-NEIISPSETITQNF---DGENIELVITNVDSE 898
W N N +P+ I + F G + + V NV +E
Sbjct: 545 WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE 581
Score = 79.8 bits (188), Expect = 1e-13
Identities = 110/486 (22%), Positives = 181/486 (37%), Gaps = 45/486 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E PP + P V +G L C+ P P I W GE + D++ + +
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 690 M-YCSVLKITNVKKFQ--EGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMI 745
L+I + +K + EG Y VA N GEA S L++ + Q P ++
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ--NP-SDVM 141
Query: 746 VRQGESVILSAQVV-GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYT 804
V GE ++ Q G+P PTI+W K+ P+ + + I +K D G Y
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK-SDAGKYV 200
Query: 805 LKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
N G E+ A +TV E P F+ R + V + + +PVP+
Sbjct: 201 CVGTNMVGERESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 253
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ W +++ + S ++ I V D G Y CVA N GK+ A +T+
Sbjct: 254 VRWRKDDGELPKSRYEIRDDHTLKIRKVTAG-----DMGSYTCVAENMVGKAEASATLTV 308
Query: 924 DV--EKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGM-------DHRE 974
V E FV + G+TV +C+ + + ++ +
Sbjct: 309 QVGSEPPHFVVK-PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 367
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETSTMLVVKETI----PEFIRK--LQ 1024
+ DVG C + T L V + I P IR+ +
Sbjct: 368 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
Query: 1025 DFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
+ + V S ++W +DG ++ + ++ + G L IR + D
Sbjct: 428 QTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG---VLQIRYAKLGDT 484
Query: 1085 GEYSCI 1090
G Y+CI
Sbjct: 485 GRYTCI 490
Score = 77.8 bits (183), Expect = 4e-13
Identities = 106/460 (23%), Positives = 183/460 (39%), Gaps = 49/460 (10%)
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM-NVTILDKPSPPGKPNILEI--DS 1394
I + L I +DAG Y N G + E+ +T+L++PS +P+ L + D
Sbjct: 179 ITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD 238
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRA 1453
S+ C E G+ V +++ D S I T I+ + +
Sbjct: 239 SAEFKC----EARGDPVP---TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
A N V ++AS T ++ V KP + + C G PQP +
Sbjct: 292 VAENMVGKAEASATL----TVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAI 346
Query: 1514 TWYRDGKK---------LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV 1564
W R+G + +++ + Y C N G + T
Sbjct: 347 FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAY 406
Query: 1565 VG----IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYN 1620
+ I +P I + Q V ++++ V G P P ++W K+G L + ++
Sbjct: 407 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLVSTQDSR 465
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD-----KPSKPEGPVI- 1674
I E V++I+ K + +YT AS +G ++ ++V + +P +P P +
Sbjct: 466 IKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524
Query: 1675 --------MREISRESVTIEWKPPLDDGGLELTKYAIEK-HEPDNNRWIKVADVDRDVET 1725
+ ++SR +VT+ W+P L+ G T Y IE + W VA+ + ET
Sbjct: 525 PSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-TSYIIEAFSHASGSSWQTVAE-NVKTET 582
Query: 1726 YCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTAL 1764
I+ L N Y+F V A N G S+ + S+P+ + L
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVL 622
Score = 73.3 bits (172), Expect = 9e-12
Identities = 110/423 (26%), Positives = 168/423 (39%), Gaps = 61/423 (14%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQD----FQMYY 560
++ P VE G C+ EG P P I W++ ++ +D +M
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 561 DDDNVATLVI---REVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXX 617
++ L I R+ P D G + CVA+N G A S + A L D +
Sbjct: 84 PSGSLFFLRIVHGRKSRP-DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ----NPS 138
Query: 618 XXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPD 677
++E PP +P + +GS + + D +G +++
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGS---------PLDDKDERITIRGGKLM-- 187
Query: 678 ENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV 737
I+ +SD Y V GT V RE E + VL+ + K P
Sbjct: 188 --ITYTRKSDAGKYVCV-----------GTNMV--GERESEVAELTVLERPSFVKRP--- 229
Query: 738 IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV 797
++ V +S + G+P PT+ W K++ LP KS + LK +KV
Sbjct: 230 ----SNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---GELP-KSRYEIRDDHTLKIRKV 281
Query: 798 K--DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVAR 855
D G YT AEN G AE SA +TV + +EPP F+ + ++ V T+
Sbjct: 282 TAGDMGSYTCVAENMVGKAEASATLTV----QVGSEPPHFVVKPRDQVVALGRTVTFQCE 337
Query: 856 VTRNPVPSITWYR---NNEIIS--PSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
T NP P+I W R N + S P ++ ++ + +L ITNV D G Y C N
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGYYICQTLN 396
Query: 911 SAG 913
AG
Sbjct: 397 VAG 399
Score = 72.9 bits (171), Expect = 1e-11
Identities = 99/400 (24%), Positives = 156/400 (39%), Gaps = 42/400 (10%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKR----GHI 1071
P + D V + + A L + T + W + GE ++ K+ + G +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 1072 RKLYIRN--TSVHDEGEYSCILRDE-----SCTAEVTVVELPPEIITRLQNQKVNKGNKA 1124
L I + S DEG Y C+ R+ S A + V L + + V G A
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 1125 TFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
E + +G + + W KDGS + + ++TI G K L I DAG+Y C N
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGK--LMITYTRKSDAGKYVCVGTN 205
Query: 1183 ------SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVI 1236
S+ + +E PS ++ P + V + A E + + ++K
Sbjct: 206 MVGERESEVAELTVLERPSF---VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVD 1292
++ + D TL IRK T D YTCV + A+++ L V+V PP V
Sbjct: 263 LPKSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 1293 YEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK-----SASLTI 1347
R+ + G VT + PQP W + P S+ + LTI
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 1348 KKVENTDAGIYKLRLENNCG----HADVEMNVTILDKPSP 1383
V+ +D G Y + N G A +E+ I D+P P
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 419
Score = 64.9 bits (151), Expect = 3e-09
Identities = 121/540 (22%), Positives = 206/540 (38%), Gaps = 60/540 (11%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH--- 787
E PP+++E +IV +GE L+ + G P PTI W K + V+ K D +H
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET--DKDDPRSHRML 82
Query: 788 ----SITILK----PKKVKDEGVYTLKAENSEGIAET-SAVITVEEPTEENAEPPLFINR 838
S+ L+ K DEGVY A N G A + +A + V ++ + P +
Sbjct: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-- 140
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSE 898
+ V E ++ +P P+I+W ++ SP + + +L+IT +
Sbjct: 141 --MVAVGEPAVME-CQPPRGHPEPTISWKKDG---SPLDDKDERITIRGGKLMIT-YTRK 193
Query: 899 IDSGDYKCVASNSAG-KSSHGARVTIDVEKVTFVKHLQK-SYETEEGKTVILECQTSHTV 956
D+G Y CV +N G + S A +T+ +E+ +FVK + ++ E +
Sbjct: 194 SDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 957 STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVV 1012
+ +W + E+ EI + D+G C+ ++ E S L V
Sbjct: 253 TVRWRKDDGELP-KSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 1013 K--ETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGE-----IIKPKKNKYD 1064
+ P F+ K +D V + E + W R+G +P ++
Sbjct: 309 QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 368
Query: 1065 FEKRGHIRKLYIRNTSVHDEGEYSCILRD------ESCTAEVT--VVELPPEIITR-LQN 1115
F L I N D G Y C + EVT + + PP +I + N
Sbjct: 369 FSV-SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
Query: 1116 QKVNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAG 1174
Q V T + W KDG + S + L+I L D G
Sbjct: 428 QTVAVDGTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 1175 EYSC----EVGNSKCTAILTVEEPSINFTLRLP-EFILVPANTDAYLTVEIPDETLDVTW 1229
Y+C G + +A + V+E + P + L+P+ ++ T+ ++W
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
Score = 55.6 bits (128), Expect = 2e-06
Identities = 110/505 (21%), Positives = 192/505 (38%), Gaps = 61/505 (12%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS-----NHIQLTID 1157
+ PP I+ + V+KG AT + + + W+K G ++ +H L
Sbjct: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
Query: 1158 GKKQKLKIYDC--DLDDAGEYSCEVGNSKCTAI---LTVEEPSINFTLRL-PEFILVPAN 1211
G L+I D G Y C N A+ ++E + R P ++V
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
Query: 1212 TDAYLTVEIPDETLD--VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
A + + P + ++W K S ++D ++ I K L+I + D +Y CV
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK---LMITYTRKSDAGKYVCV 202
Query: 1270 LLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--------PQPNDEW 1321
+ + EV E + ER +KR S++ + VD A P P W
Sbjct: 203 --GTNMVGERESEVAE----LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K ++ +L I+KV D G Y EN G A+ +T+
Sbjct: 257 RKDDGELPKSRYEIRD----DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 1382 SPPG---KPNILEIDSSSINICWDEPENTGN-STIIYY--------VVEYQEIDTTEWIS 1429
PP KP ++ + + + + E TGN I++ + YQ ++ S
Sbjct: 313 EPPHFVVKPRD-QVVALGRTVTF-QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 1430 VKNI-TKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EK 1486
V T T++Q +++ Y Y ++++ + T Y +V + P V +
Sbjct: 371 VSQTGDLTITNVQ--RSDVGY----YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424
Query: 1487 PLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXX 1544
P+ N T + L+C+ G P P + W +DG + T + +
Sbjct: 425 PV-NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 483
Query: 1545 XXXYKCIAFNDHGEVETSCVVGIQQ 1569
Y CIA GE S + +Q+
Sbjct: 484 TGRYTCIASTPSGEATWSAYIEVQE 508
Score = 48.8 bits (111), Expect = 2e-04
Identities = 62/246 (25%), Positives = 93/246 (37%), Gaps = 38/246 (15%)
Query: 502 TSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA-----IIKPSQDF 556
T + S P FV K R + G TV F+C+ G P+P I W R+ + +P Q
Sbjct: 307 TVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS- 365
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXX 616
+ L I V D G + C N AG +I +A L E+T
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG------SIITKAYL-----EVTDV-- 412
Query: 617 XXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP 676
I + PP + P Q V +L C P P I W G +
Sbjct: 413 -----------IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST 461
Query: 677 DENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT--GEKEP 734
++ +E+ VL+I K G YT +A GEA+ ++++ +P
Sbjct: 462 QDSRIKQLEN------GVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
Query: 735 PQVIEP 740
P+ +P
Sbjct: 516 PRPTDP 521
Score = 48.8 bits (111), Expect = 2e-04
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSVHE 1924
PS P V++ + +VTL W +P N G+ T+YIIE F G SW + V
Sbjct: 525 PSAPSKPEVTDVSRNTVTLSW-QPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTET 582
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE 1953
I+ +K +F + A N G+S P++
Sbjct: 583 SAIKGLKPNAIYLFLVRAANAYGISDPSQ 611
Score = 46.8 bits (106), Expect = 9e-04
Identities = 31/97 (31%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 1965 VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTMWMEVGKVDVNT 2023
+PS P+ P E+ V N V SW P + GA Y I A + + W V + +V T
Sbjct: 524 IPSAPSKP-EVTDVSRNTVTLSW-QPNLNSGATPTSYIIEAFSHASGSSWQTVAE-NVKT 580
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
I+ L N Y+ + A N G+S+P + +P K
Sbjct: 581 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Score = 38.7 bits (86), Expect = 0.23
Identities = 36/159 (22%), Positives = 58/159 (36%), Gaps = 10/159 (6%)
Query: 1507 GVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV 1564
G P+P ++W +DG L K + T Y C+ N GE E+
Sbjct: 157 GHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVA 215
Query: 1565 -VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITT 1623
+ + ++P ++ V D G P P V W K+ +L + Y I
Sbjct: 216 ELTVLERPSFVKRPSNLAV--TVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEI-- 270
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++I+++ YT A N G + TL V
Sbjct: 271 -RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
>AF245505-1|AAF86402.1| 2828|Homo sapiens adlican protein.
Length = 2828
Score = 95.9 bits (228), Expect = 1e-18
Identities = 180/935 (19%), Positives = 341/935 (36%), Gaps = 72/935 (7%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P +K P+ V +D + C P+P + W + N I+ +
Sbjct: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPN--TRIQRFEVLKN 1910
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I V+ G Y A N G + ++L + ++P + + + V G+++
Sbjct: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTV--QQPQILASHYQDVTVYLGDTI 1968
Query: 753 ILSAQVVGNPRPTITWCKNNKPV--KALPTKSDGDTHSITILKPKKV--KDEGVYTLKAE 808
+ G P P I+W ++ V P +S H L K+ D GVY A
Sbjct: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVESRITLHENRTLSIKEASFSDRGVYKCVAS 2028
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
N+ G + + V P + + + I++ +I + P+PS+ W
Sbjct: 2029 NAAGADSLAIRLHVAA-----LPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVL 2083
Query: 869 NNEI-ISPSETITQN-FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID-- 924
+ I PS+ + N F N L I N+ + DSG Y+CVA+N G + ++ +
Sbjct: 2084 GDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPK-DSGRYECVAANLVGSARRTVQLNVQRA 2142
Query: 925 VEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--W-YHNKKEISGM-DHREIIQEGR 980
+ + G T+ L+C S + W +K+ I + I+
Sbjct: 2143 AANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFA 2202
Query: 981 XXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEK------DVA 1034
D G C+ +++ +V+K + K++ E + D+
Sbjct: 2203 NGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLK 2262
Query: 1035 ILEVEINSETADVVWE-RDGEIIKPKKNKYDFEKRG------HIRKLYIRNTSVHDEGEY 1087
+ V ++ W DG ++ D R + LY + +EG+Y
Sbjct: 2263 VDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY 2322
Query: 1088 SCILRD----ESCTAEVTVVELPPEIITRLQ-NQKVNKGNKATFEIELTKGDAL--VRWF 1140
+C + + V VV P I + +V G+ T E KG+ + V W
Sbjct: 2323 TCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACE-AKGEPMPKVTWL 2381
Query: 1141 KDGSEI--QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS-----KCTAI-LTVE 1192
+++ S Q+ DG L I D+G Y+C V NS K I + V+
Sbjct: 2382 SPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQ 2438
Query: 1193 EPSINFTLRLPEFILVPANTDAYLTVEIPDE---TLDVTWYKKKSVIEDTEKF-TLISDV 1248
P IN + A + ++ E T V W + V+ + I+
Sbjct: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVH 2498
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPP--KIVDYE---REYRIKRGS 1303
+L IR + D + C+ + +L V++ P K + ++ + G
Sbjct: 2499 GNGSLDIRSLRKSDSVQLVCMARNEGGEARLIVQLTVLEPMEKPIFHDPISEKITAMAGH 2558
Query: 1304 DVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
++L P P+ W++ N ++ + + L I + + DAG Y+
Sbjct: 2559 TISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVA 2618
Query: 1363 ENNCGHADVEMNVTILDKPSPPGK-PNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE 1421
N GH + +++ + KP + N++ I + P G + +
Sbjct: 2619 RNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMH 2678
Query: 1422 IDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVN-EVDISDASETTEYYKVIKETKIQ 1480
++ + ++ ++ ++ S + Y E + + + + +I
Sbjct: 2679 LEGPQ--TLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRIT 2736
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW 1515
S +P I T P ++L C+ G+P+ +TW
Sbjct: 2737 S----EPTPVIYTRPGNTVKLNCMAMGIPKADITW 2767
Score = 75.8 bits (178), Expect = 2e-12
Identities = 155/761 (20%), Positives = 275/761 (36%), Gaps = 84/761 (11%)
Query: 511 IFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAI-IKPSQDFQMYYDDDNVATLV 569
I EKL P G ++ C + P P + W I+PSQ TL
Sbjct: 2049 IHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLY 2108
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADIL 629
IR + P+D+G + CVA N G A T +L V+ ++
Sbjct: 2109 IRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN----------------------- 2145
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
I T ++ +Y G + L+C P P I W + ++ + + +S +
Sbjct: 2146 ARITGTSPRRTDVRY---GGTLKLDCSASGDPWPRILWRLPSKRMI---DALFSFDSRIK 2199
Query: 690 MYCS-VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ 748
++ + L + +V G Y VA N+ G+ +VLK+ K + V
Sbjct: 2200 VFANGTLVVKSVTDKDAGDYLCVARNKVGDDY--VVLKVDVVMKPAKIEHKEENDHKVFY 2257
Query: 749 GESVILSAQVVGNPRPTITW-CKNNKPVKALPTKSD--GDTHSITI-------LKPKKVK 798
G + + G P P I+W + V + D G T + ++
Sbjct: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
+EG YT AEN G E + V A + + + V + +
Sbjct: 2318 EEGDYTCFAENQVGKDEMRVRVKV-----VTAPATIRNKTYLAVQVPYGDVVTVACEAKG 2372
Query: 859 NPVPSITWYR-NNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
P+P +TW N++I S Q + ++ L+I DSG+Y C+ NSAG+
Sbjct: 2373 EPMPKVTWLSPTNKVIPTSSEKYQIY--QDGTLLIQKAQRS-DSGNYTCLVRNSAGEDRK 2429
Query: 918 GARVTIDVEKVTFVKHLQKSYETEE----GKTVILECQTS--HTVSTKWYHNKKEISGMD 971
+ ++V+ + E G +++C+ T W + +
Sbjct: 2430 TVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAP 2489
Query: 972 H--REIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRK-LQDFEV 1028
+ I G V ++ C+ +++ L+V+ T+ E + K + +
Sbjct: 2490 YYGNRITVHGNGSLDIRSLRKSDSVQLV-CMARNEGGEARLIVQLTVLEPMEKPIFHDPI 2548
Query: 1029 KEKDVAIL--EVEIN-----SETADVVWE-RDGEIIKPKKNKYDFEKRGHIRKLYIRNTS 1080
EK A+ + +N + T +VW +G ++ + F + L+I S
Sbjct: 2549 SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKAD-GMLHISGLS 2607
Query: 1081 VHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELT---KGD 1134
D G Y C+ R+ + E V V L PE + N V+ N T ++ T G
Sbjct: 2608 SVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHN-LVSIINGETLKLPCTPPGAGQ 2666
Query: 1135 ALVRW-FKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE 1193
W +G ++ + L + + + D G Y C + ++ ++
Sbjct: 2667 GRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPV 2726
Query: 1194 PSINFTLRL-----PEFILVPANTDAYLTVEIPDETLDVTW 1229
I + R+ P P NT + + D+TW
Sbjct: 2727 IVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITW 2767
Score = 74.9 bits (176), Expect = 3e-12
Identities = 171/830 (20%), Positives = 297/830 (35%), Gaps = 85/830 (10%)
Query: 599 IVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTF-SKKPKAQYVDEGSDILLECRL 657
I EA SD G V + +PP +K + + G I + C
Sbjct: 2012 IKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTA 2071
Query: 658 VAIPEPDIAWLF-KGEEIVPDENISVAIESDMHMYCS-VLKITNVKKFQEGTYTVVAVNR 715
A P P + W+ G +I P + + ++ ++ + L I N+ G Y VA N
Sbjct: 2072 KAAPLPSVRWVLGDGTQIRPSQ----FLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANL 2127
Query: 716 EGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITW-CKNNKP 774
G A + L ++ + VR G ++ L G+P P I W + +
Sbjct: 2128 VGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRM 2187
Query: 775 VKAL---PTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ AL ++ + ++K KD G Y A N G + V+ V+ +
Sbjct: 2188 IDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG--DDYVVLKVDVVMK---- 2241
Query: 832 PPLFINRFQEITVKE--KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIE 889
P I +E K G +K+ T P P I+W + + S + + G
Sbjct: 2242 -PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKR 2300
Query: 890 LVITNVDS----EI---DSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
V+ N + E+ + GDY C A N GK RV + T + +
Sbjct: 2301 YVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPY 2360
Query: 943 GKTVILECQTSHTVSTK--WYH--NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIK 998
G V + C+ K W NK + + +I Q+G D G
Sbjct: 2361 GDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYT 2417
Query: 999 CIVKD---QETSTMLVVKETIPEFIRKLQDFEVKEKDVA------ILEVEINS-ETADVV 1048
C+V++ ++ T+ + P I + +++A +++ + T V+
Sbjct: 2418 CLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVL 2477
Query: 1049 WERDGEIIKPKK---NKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTA----EVT 1101
W ++ P N+ G L IR+ D + C+ R+E A ++T
Sbjct: 2478 WAFPEGVVLPAPYYGNRITVHGNG---SLDIRSLRKSDSVQLVCMARNEGGEARLIVQLT 2534
Query: 1102 VVE-LPPEIITRLQNQKVNKGNKATFEIEL----TKGDALVRWFKDGSEIQFSNHIQLTI 1156
V+E + I ++K+ T + T +LV +G+++Q +Q
Sbjct: 2535 VLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFY 2594
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNS-----KCTAILTVEEPSINFTLRLPEFILVPAN 1211
L I DAG Y C N+ + ++ +P N + + +
Sbjct: 2595 HKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN--KQYHNLVSIING 2652
Query: 1212 TDAYLTVEIPDETLD-VTWYKKKSV-IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
L P +W + +E + +S + TL +R+ + D+ Y C
Sbjct: 2653 ETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCR 2712
Query: 1270 LLD--AKSTTKLKVEVVEFPPKIVDYEREYRIKR-GSDVTLLVDYQAFPQPNDEWIVNSK 1326
+ S T + V V+ +PP+I R G+ V L P+ + W + K
Sbjct: 2713 METEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDK 2772
Query: 1327 IIKKCKHTKPSIDSK---------SASLTIKKVENTDAGIYKLRLENNCG 1367
H K + ++ SLTI+ DAG YK +N G
Sbjct: 2773 -----SHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILG 2817
Score = 73.7 bits (173), Expect = 6e-12
Identities = 136/660 (20%), Positives = 247/660 (37%), Gaps = 46/660 (6%)
Query: 1072 RKLYIRNTSVHDEGEYSCILRD----ESCTAEVTVVELPPEIIT-RLQNQKVNKGNKATF 1126
R L I+ S D G Y C+ + +S + V LPP I +L+N + G +
Sbjct: 2008 RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPG--LSI 2065
Query: 1127 EIELTKGDA---LVRW-FKDGSEIQFSNHIQLTIDG-KKQKLKIYDCDLDDAGEYSCE-- 1179
I T A VRW DG++I+ S + + L I + D+G Y C
Sbjct: 2066 HIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAA 2125
Query: 1180 --VGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIP---DETLDVTW-YKKK 1233
VG+++ T L V+ + N + L ++ D + W K
Sbjct: 2126 NLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSK 2185
Query: 1234 SVIEDTEKF-TLISDVKKRTLIIRKCTEDDQCEYTCVLLD--AKSTTKLKVEVVEFPPKI 1290
+I+ F + I TL+++ T+ D +Y CV + LKV+VV P KI
Sbjct: 2186 RMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKI 2245
Query: 1291 VDYER-EYRIKRGSDVTLLVDYQAFPQPNDEW------IVNSKIIKKCK--HTKPSIDSK 1341
E ++++ G D+ + P P W +VNS + TK +
Sbjct: 2246 EHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFN 2305
Query: 1342 SASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICW 1401
+ +L +V + G Y EN G ++ + V ++ P+ L + ++
Sbjct: 2306 NGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVT 2365
Query: 1402 DEPENTGNSTI-IYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVD 1460
E G + ++ ++ T + IQ + + S + N
Sbjct: 2366 VACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSA- 2424
Query: 1461 ISDASETTEYYKVIKETKIQ-SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTW-YRD 1518
+ +T + ++ KI +P ++ I + + + C G+P P+V W + +
Sbjct: 2425 -GEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKL-IDCKAEGIPTPRVLWAFPE 2482
Query: 1519 GKKLKTA----KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVIT 1574
G L + T C+A N+ GE + + +
Sbjct: 2483 GVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLIVQLTVLEPMEKP 2542
Query: 1575 ISNEDIKQK--HKVGDEWLVTAVIEGIPPPEVIWY-KNGNKLENDKEYNITTKEKTSVIR 1631
I ++ I +K G + G P P ++W NG L++ ++ + ++
Sbjct: 2543 IFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLH 2602
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKP-SKPEGPVIMREISRESVTIEWKPP 1690
I L + Y A N AG + V+LKV KP + + ++ I+ E++ + PP
Sbjct: 2603 ISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPP 2662
Score = 69.7 bits (163), Expect = 1e-10
Identities = 99/504 (19%), Positives = 186/504 (36%), Gaps = 36/504 (7%)
Query: 1192 EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLD-VTWYKKKS--VIEDTEKFTLISDV 1248
E+P I + P+ + V A TD E + VTW K + ++ + +
Sbjct: 1851 EKPQI--LTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVL 1908
Query: 1249 KKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKV---EVVEFPPKIVDYEREYRIKRGSDV 1305
K TL+IRK D+ +Y C + ++ V V+ P + + ++ + G +
Sbjct: 1909 KNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTI 1968
Query: 1306 TLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSID-SKSASLTIKKVENTDAGIYKLRLE 1363
+ + P P WI + ++ + + I ++ +L+IK+ +D G+YK
Sbjct: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVESRITLHENRTLSIKEASFSDRGVYKCVAS 2028
Query: 1364 NNCGHADVEMNVTILDKPSPPGKPNILEID---SSSINI-CWDEPENTGNSTIIYYVVEY 1419
N G + + + + P + + I SI+I C + ++ + + +
Sbjct: 2029 NAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHC--TAKAAPLPSVRWVLGDG 2086
Query: 1420 QEIDTTEWI--SVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKET 1477
+I ++++ ++ I+NL S R+ A N V + + +
Sbjct: 2087 TQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146
Query: 1478 KIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR----- 1532
+I T P + ++L C G P P++ W K++ A ++++R
Sbjct: 2147 RI---TGTSP-RRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFA 2202
Query: 1533 -XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWL 1591
Y C+A N G+ V + KP E+ K G +
Sbjct: 2203 NGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLK 2262
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLEN----DKEYNITTKE----KTSVIRIKELKRSHSSKY 1643
V V G+P PE+ W L N + TK + E+ Y
Sbjct: 2263 VDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY 2322
Query: 1644 TIEASNTAGTSSVEVTLKVYDKPS 1667
T A N G + V +KV P+
Sbjct: 2323 TCFAENQVGKDEMRVRVKVVTAPA 2346
Score = 64.9 bits (151), Expect = 3e-09
Identities = 57/240 (23%), Positives = 102/240 (42%), Gaps = 21/240 (8%)
Query: 733 EPPQVIEPLKSMIVRQGES-VILSAQVVGNPRPTITWCKNNKPVKALPT----KSDGDTH 787
E PQ++ + E+ + + G P+P +TW K + P + + +
Sbjct: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
+++ +V+D G Y A N G+ +++V +P + + +Q++TV
Sbjct: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTV-----QQPQILASHYQDVTVYLG 1965
Query: 848 GTIKLVARVTRNPVPSITWY----RNNEIISPSET-ITQNFDGENIELVITNVDSEIDSG 902
TI + P P I+W R + +SP E+ IT + EN L I S D G
Sbjct: 1966 DTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVESRITLH---ENRTLSIKEA-SFSDRG 2021
Query: 903 DYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILEC--QTSHTVSTKW 960
YKCVASN+AG S R+ + + ++ G ++ + C + + S +W
Sbjct: 2022 VYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRW 2081
Score = 64.5 bits (150), Expect = 4e-09
Identities = 150/672 (22%), Positives = 238/672 (35%), Gaps = 63/672 (9%)
Query: 1047 VVWER--DGEIIKPKKNKYDFE--KRGHIRKLYIRNTSVHDEGEYSCILR-----DESCT 1097
V W + G ++ P FE K G L IR V D G+Y C D
Sbjct: 1885 VTWTKVSTGALMTPNTRIQRFEVLKNG---TLVIRKVQVQDRGQYMCTASNLHGLDRMVV 1941
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRW-FKDGSEIQFSNHIQL 1154
V+ P + + Q+ V G+ E L KG + W F D Q + ++
Sbjct: 1942 LLSVTVQQPQILASHYQDVTVYLGDTIAMEC-LAKGTPAPQISWIFPDRRVWQTVSPVES 2000
Query: 1155 TID-GKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEE-----PSINFTLRLPEFILV 1208
I + + L I + D G Y C N+ L + P + +L E I +
Sbjct: 2001 RITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKL-ENISL 2059
Query: 1209 PANTDAYLTVEIPDETL-DVTWYKKKSVIEDTEKFTL--ISDVKKRTLIIRKCTEDDQCE 1265
P ++ L V W +F + TL IR D
Sbjct: 2060 PPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGR 2119
Query: 1266 YTCVLLD----AKSTTKLKVEVVEFPPKIVDYE-REYRIKRGSDVTLLVDYQAFPQPNDE 1320
Y CV + A+ T +L V+ +I R ++ G + L P P
Sbjct: 2120 YECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRIL 2179
Query: 1321 WIVNSKIIKKCKHTKPSIDSK-----SASLTIKKVENTDAGIYKLRLENNCGHADVEMNV 1375
W + SK + S DS+ + +L +K V + DAG Y N G V + V
Sbjct: 2180 WRLPSKRMIDALF---SFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKV 2236
Query: 1376 TILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITK 1435
++ K P K E + + D + + + + + D + V + +
Sbjct: 2237 DVVMK---PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGS---LVNSFMQ 2290
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYK--VIK-ETKIQSPTVEKP--LKN 1490
+ S K + NEV + + + T + + V K E +++ V P ++N
Sbjct: 2291 SDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRN 2350
Query: 1491 IT----TEPNEDI-ELTCIFGGVPQPKVTWYRDGKK-LKTAKATYE--NRXXXXXXXXXX 1542
T P D+ + C G P PKVTW K + T+ Y+
Sbjct: 2351 KTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQR 2410
Query: 1543 XXXXXYKCIAFNDHGEVETSCVVGIQ-QKPVITISNEDIKQKHKV---GDEWLVTAVIEG 1598
Y C+ N GE + + + Q P I + I ++ G L+ EG
Sbjct: 2411 SDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEG 2470
Query: 1599 IPPPEVIW-YKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVE 1657
IP P V+W + G L N T + I+ L++S S + A N G + +
Sbjct: 2471 IPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLI 2530
Query: 1658 VTLKVYDKPSKP 1669
V L V + KP
Sbjct: 2531 VQLTVLEPMEKP 2542
Score = 60.9 bits (141), Expect = 5e-08
Identities = 109/493 (22%), Positives = 186/493 (37%), Gaps = 69/493 (13%)
Query: 474 LMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQV 533
+ +E +YT + + ++ + D++ V K + + A I + P G V C+
Sbjct: 2316 MREEGDYTCFAENQVGK--DEMRVRVKVVT---APATIRNKTYLAVQVPYGDVVTVACEA 2370
Query: 534 EGYPRPQITWFRQTAIIKP--SQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGF 591
+G P P++TW T + P S+ +Q+Y D TL+I++ D+G +TC+ +N+AG
Sbjct: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQD----GTLLIQKAQRSDSGNYTCLVRNSAGE 2426
Query: 592 ASSTT--ELIVEAP-LSDHGSEMTVXXXXXXXXXXXXADI-LEGIPPTFSKKPKAQYV-D 646
T + V+ P ++ + + +T D EGIP P+ +
Sbjct: 2427 DRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIP-----TPRVLWAFP 2481
Query: 647 EGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEG 706
EG V +P P + G I N S+ I S ++K
Sbjct: 2482 EG---------VVLPAP-----YYGNRITVHGNGSLDIRS-------------LRKSDSV 2514
Query: 707 TYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ-GESVILSAQVVGNPRPT 765
+A N GEA L + L + E P +P+ I G ++ L+ G P P+
Sbjct: 2515 QLVCMARNEGGEARLIVQLTV-LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPS 2573
Query: 766 ITW-------CKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA 818
+ W ++ + ++ K+DG H + D G Y A N+ G E
Sbjct: 2574 LVWVLPNGTDLQSGQQLQRFYHKADGMLH----ISGLSSVDAGAYRCVARNAAGHTERLV 2629
Query: 819 VITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEI-ISPSE 877
+ V E N + + N +++ T+KL +W N + + +
Sbjct: 2630 SLKVGLKPEANKQ---YHNL---VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQ 2683
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS 937
T+ + +N L + S D G Y C G S V +
Sbjct: 2684 TLGRVSLLDNGTLTVREA-SVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPV 2742
Query: 938 YETEEGKTVILEC 950
T G TV L C
Sbjct: 2743 IYTRPGNTVKLNC 2755
Score = 54.4 bits (125), Expect = 4e-06
Identities = 63/288 (21%), Positives = 113/288 (39%), Gaps = 20/288 (6%)
Query: 831 EPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR--NNEIISPSETITQNFDG-EN 887
+P + Q ++V + T P P +TW + +++P+ I Q F+ +N
Sbjct: 1852 KPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRI-QRFEVLKN 1910
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVI 947
LVI V + D G Y C ASN G +++ V++ + + G T+
Sbjct: 1911 GTLVIRKVQVQ-DRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIA 1969
Query: 948 LECQTSHTVSTK--WYHNKKE----ISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIV 1001
+EC T + + W + +S ++ R + E R D GV KC+
Sbjct: 1970 MECLAKGTPAPQISWIFPDRRVWQTVSPVESRITLHENR--TLSIKEASFSDRGVYKCVA 2027
Query: 1002 KDQETSTMLVVK---ETIPEFIRKLQDFEVKEKDVAILEVEINSETA---DVVWE-RDGE 1054
+ + L ++ +P I + + + + + ++ A V W DG
Sbjct: 2028 SNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGT 2087
Query: 1055 IIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
I+P + + LYIRN + D G Y C+ + +A TV
Sbjct: 2088 QIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTV 2135
Score = 49.6 bits (113), Expect = 1e-04
Identities = 65/278 (23%), Positives = 104/278 (37%), Gaps = 23/278 (8%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGT 707
G I L C P P + W+ D ++ H +L I+ + G
Sbjct: 2557 GHTISLNCSAAGTPTPSLVWVLPNGT---DLQSGQQLQRFYHKADGMLHISGLSSVDAGA 2613
Query: 708 YTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTIT 767
Y VA N G + LK+ + E + L S+I GE++ L G + +
Sbjct: 2614 YRCVARNAAGHTERLVSLKVGL-KPEANKQYHNLVSII--NGETLKLPCTPPGAGQGRFS 2670
Query: 768 WCKNN----KPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSA-VITV 822
W N + + L S D ++T+ + V D G Y + E G + TS VI +
Sbjct: 2671 WTLPNGMHLEGPQTLGRVSLLDNGTLTV-REASVFDRGTYVCRMETEYGPSVTSIPVIVI 2729
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
P +EP I + T+KL P ITW ++ + +
Sbjct: 2730 AYPPRITSEPT------PVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARL 2783
Query: 883 FDGENIE----LVITNVDSEIDSGDYKCVASNSAGKSS 916
+ + L I + ++ D+G YKC+A N G S
Sbjct: 2784 YGNRFLHPQGSLTIQHA-TQRDAGFYKCMAKNILGSDS 2820
Score = 47.2 bits (107), Expect = 6e-04
Identities = 48/198 (24%), Positives = 79/198 (39%), Gaps = 35/198 (17%)
Query: 523 DGSTVQFECQVEGYPRPQITW-FRQTAIIK-PSQDFQMYYDDDNVATLVIREVFPEDAGT 580
+G Q C V+ P I W +I+K P D + + L I+ + P D+G
Sbjct: 493 EGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGL 552
Query: 581 FTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKP 640
+ C+A+ ++V++P + + TV T K P
Sbjct: 553 YQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTV---------------------TIGKNP 591
Query: 641 KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS-VLKITN 699
G + L C +AIPE ++W+ I+ D +A S ++M + L I
Sbjct: 592 -------GESVTLPCNALAIPEAHLSWILPNRRIIND----LANTSHVYMLPNGTLSIPK 640
Query: 700 VKKFQEGTYTVVAVNREG 717
V+ G Y VAVN++G
Sbjct: 641 VQVSDSGYYRCVAVNQQG 658
Score = 46.8 bits (106), Expect = 9e-04
Identities = 28/80 (35%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 524 GSTVQFECQVEGYPRPQITW-FRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
G T+ EC +G P PQI+W F + + + TL I+E D G +
Sbjct: 1965 GDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVESRITLHENRTLSIKEASFSDRGVYK 2024
Query: 583 CVAKNAAGFASSTTELIVEA 602
CVA NAAG S L V A
Sbjct: 2025 CVASNAAGADSLAIRLHVAA 2044
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/99 (32%), Positives = 50/99 (50%), Gaps = 8/99 (8%)
Query: 521 TPDGSTVQFECQVEGYPRPQITWFRQT--AIIKPSQDFQMYYDDDNVATLVIREVFPEDA 578
T + TV F C+ G P+P +TW + + A++ P+ Q + N TLVIR+V +D
Sbjct: 1866 TAETDTV-FPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN-GTLVIRKVQVQDR 1923
Query: 579 GTFTCVAKNAAGFASSTT--ELIVEAP--LSDHGSEMTV 613
G + C A N G + V+ P L+ H ++TV
Sbjct: 1924 GQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
Score = 44.0 bits (99), Expect = 0.006
Identities = 33/130 (25%), Positives = 53/130 (40%), Gaps = 8/130 (6%)
Query: 474 LMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQV 533
+ D Y ++ + + +PV + P V RP G+TV+ C
Sbjct: 2703 VFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRP-----GNTVKLNCMA 2757
Query: 534 EGYPRPQITW-FRQTAIIKPSQDFQMYYDD--DNVATLVIREVFPEDAGTFTCVAKNAAG 590
G P+ ITW + +K ++Y + +L I+ DAG + C+AKN G
Sbjct: 2758 MGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILG 2817
Query: 591 FASSTTELIV 600
S TT + V
Sbjct: 2818 SDSKTTYIHV 2827
Score = 42.7 bits (96), Expect = 0.014
Identities = 58/241 (24%), Positives = 92/241 (38%), Gaps = 28/241 (11%)
Query: 1486 KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGK-KLKTAKATYEN-----RXXXXXXX 1539
K + ++ D C G P+P VTW + L T +
Sbjct: 1858 KSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRK 1917
Query: 1540 XXXXXXXXYKCIAFNDHG--EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIE 1597
Y C A N HG + V +QQ ++ +D+ +GD + + +
Sbjct: 1918 VQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVY--LGDTIAMECLAK 1975
Query: 1598 GIPPPEVIWYKNGNKL---ENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
G P P++ W ++ + E IT E + + IKE S Y ASN AG
Sbjct: 1976 GTPAPQISWIFPDRRVWQTVSPVESRITLHENRT-LSIKEASFSDRGVYKCVASNAAGAD 2034
Query: 1655 SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP-DNNRW 1713
S+ + L V P PVI +E E++++ PP GL + + K P + RW
Sbjct: 2035 SLAIRLHVAALP-----PVIHQE-KLENISL---PP----GLSIHIHCTAKAAPLPSVRW 2081
Query: 1714 I 1714
+
Sbjct: 2082 V 2082
Score = 39.9 bits (89), Expect = 0.098
Identities = 51/220 (23%), Positives = 91/220 (41%), Gaps = 22/220 (10%)
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSV-----LKI 697
Q V EG L C + A P I W ++PD +I A D S+ L+I
Sbjct: 489 QTVLEGGPCQLSCNVKASESPSIFW------VLPDGSILKAPMDDPDSKFSILSSGWLRI 542
Query: 698 TNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQ 757
+++ G Y +A R+ + + +++ +P + + ++ GESV L
Sbjct: 543 KSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAE--KDTVTIGKNPGESVTLPCN 600
Query: 758 VVGNPRPTITWCKNNKPV--KALPTKSDGDTHSITILKPK-KVKDEGVYTLKAENSEGIA 814
+ P ++W N+ + T + T+ PK +V D G Y A N +G
Sbjct: 601 ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
Query: 815 ETSAVITVEE-----PTEENAEP-PLFINRFQEITVKEKG 848
+ ITV + P++ P ++R +E V+++G
Sbjct: 661 HFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIVEDEG 700
Score = 39.9 bits (89), Expect = 0.098
Identities = 38/155 (24%), Positives = 69/155 (44%), Gaps = 8/155 (5%)
Query: 1233 KSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIV 1291
K+ ++D + KF+++S R I+ D Y C+ ++ V+ P
Sbjct: 522 KAPMDDPDSKFSILSSGWLR---IKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQ 578
Query: 1292 DYERE-YRIKR--GSDVTLLVDYQAFPQPNDEWIV-NSKIIKKCKHTKPSIDSKSASLTI 1347
E++ I + G VTL + A P+ + WI+ N +II +T + +L+I
Sbjct: 579 PAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSI 638
Query: 1348 KKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
KV+ +D+G Y+ N G + +T+ K S
Sbjct: 639 PKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGS 673
Score = 35.9 bits (79), Expect = 1.6
Identities = 45/199 (22%), Positives = 75/199 (37%), Gaps = 18/199 (9%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI- 791
EP ++ + V +G LS V + P+I W + + P SI
Sbjct: 480 EPSGAVQ--RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS 537
Query: 792 ----LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITV-KE 846
+K + D G+Y A+ + + + V+ P+ + AE +T+ K
Sbjct: 538 GWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEK-------DTVTIGKN 590
Query: 847 KG-TIKLVARVTRNPVPSITWYR-NNEIISPSETITQNFDGENIELVITNVDSEIDSGDY 904
G ++ L P ++W N II+ + + N L I V DSG Y
Sbjct: 591 PGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVS-DSGYY 649
Query: 905 KCVASNSAGKSSHGARVTI 923
+CVA N G +T+
Sbjct: 650 RCVAVNQQGADHFTVGITV 668
>BC039255-1|AAH39255.1| 617|Homo sapiens CNTN5 protein protein.
Length = 617
Score = 95.5 bits (227), Expect = 2e-18
Identities = 120/545 (22%), Positives = 215/545 (39%), Gaps = 34/545 (6%)
Query: 1285 EFPPKI-VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI-VNSKIIKKCKHTKPSIDSKS 1342
E+ PKI V + +G+ V + P P W+ VN I K + K
Sbjct: 3 EYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRK-----SQ 57
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWD 1402
A L I V+ DAGIY+ R EN+ G + + P K N ++DS S + W
Sbjct: 58 AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGS-PLRW- 115
Query: 1403 EPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDIS 1462
E + TG Y ++ + + V+ + I N+ + + ++ A N+
Sbjct: 116 ECKATGKPRPTYRWLK-NGVPLSPQSRVEMVNGV-LMIHNVNQSDAGMYQCLAENKYGAI 173
Query: 1463 DASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL 1522
AS K++ + + + K I ++++ + C G P+P ++W + + +
Sbjct: 174 YASAE---LKIL--ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAV 228
Query: 1523 KTAK-ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIK 1581
+ K Y C N G E + +++ I ++ + +
Sbjct: 229 RENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPK--R 286
Query: 1582 QKHKVGDEWLVT--AVIEGIPPPEVIWYKNGNKLENDKE----YNITTKEKTSVIRIKEL 1635
+ VG+ ++ A+ + W G ++ ++E +I + ++ + I+ +
Sbjct: 287 TELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNI 346
Query: 1636 KRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGG 1695
H+ +Y TA + S E L V P P G VI+ EI+ + T+ W P D+
Sbjct: 347 LLMHAGRYGCRVQTTADSVSDEAELLVRGPPG-PPGIVIVEEITESTATLSWSPAADNHS 405
Query: 1696 LELTKYAIEKHEPDNNRWIKVADVDR----DVETYCIQKLNENCEYMFRVIAQNPVGFSE 1751
++ Y ++ P + W V V D+E+ LN EY FRV+A NP+G +
Sbjct: 406 -PISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGD 464
Query: 1752 ALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP-SEKNGGSPIIDYKVEIKQEG 1810
+ +I+T VP + I W P SE+ Y V + G
Sbjct: 465 P-STPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNG 523
Query: 1811 KK-WK 1814
+ WK
Sbjct: 524 TRGWK 528
Score = 85.4 bits (202), Expect = 2e-15
Identities = 69/235 (29%), Positives = 107/235 (45%), Gaps = 19/235 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P + +K +D GS + EC+ P P WL G + P +S + M
Sbjct: 96 PHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP--------QSRVEMVNG 147
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLK-SMIVRQGESV 752
VL I NV + G Y +A N+ G LKI P + LK ++IV + + V
Sbjct: 148 VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKDQEV 205
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ + G+P+PTI+W K ++ V+ + S+ IL K DEG Y + EN G
Sbjct: 206 VIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK-SDEGKYVCRGENVFG 264
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWY 867
AE A ++V+EPT P + E+TV E +I L + + +T+Y
Sbjct: 265 SAEIIASLSVKEPTRIELTP-----KRTELTVGE--SIVLNCKAIHDASLDVTFY 312
Score = 85.0 bits (201), Expect = 3e-15
Identities = 76/312 (24%), Positives = 134/312 (42%), Gaps = 26/312 (8%)
Query: 647 EGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEG 706
+G+ + +EC + P P I W+ K +P ++ + +VL+I NV+ G
Sbjct: 20 KGTTVKMECFALGNPVPTITWM-KVNGYIPS-------KARLRKSQAVLEIPNVQLDDAG 71
Query: 707 TYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTI 766
Y A N G+ S L++ T P +E L + G + + G PRPT
Sbjct: 72 IYECRAENSRGKNSFRGQLQVYT----YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTY 127
Query: 767 TWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPT 826
W KN P+ P + + ++ D G+Y AEN G SA + +
Sbjct: 128 RWLKNGVPLS--PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILA-- 183
Query: 827 EENAEPPLFINRFQE-ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDG 885
+ P +N+ ++ I V + + + + +P P+I+W + + + ++ I DG
Sbjct: 184 ---SAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDG 240
Query: 886 ENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKT 945
L I N S+ D G Y C N G + A ++ V++ T ++ K E G++
Sbjct: 241 ---SLRILNA-SKSDEGKYVCRGENVFGSAEIIA--SLSVKEPTRIELTPKRTELTVGES 294
Query: 946 VILECQTSHTVS 957
++L C+ H S
Sbjct: 295 IVLNCKAIHDAS 306
Score = 78.2 bits (184), Expect = 3e-13
Identities = 93/375 (24%), Positives = 150/375 (40%), Gaps = 35/375 (9%)
Query: 730 GEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTH 787
GE EP + ++ +G +V + +GNP PTITW K N P KA KS
Sbjct: 2 GEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKS----Q 57
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEK 847
++ + ++ D G+Y +AENS G + V P ++ + + +
Sbjct: 58 AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQV-------YTYPHWVEKLNDTQLDSG 110
Query: 848 GTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCV 907
++ + T P P+ W +N +SP + + N L+I NV ++ D+G Y+C+
Sbjct: 111 SPLRWECKATGKPRPTYRWLKNGVPLSPQSRV----EMVNGVLMIHNV-NQSDAGMYQCL 165
Query: 908 ASNSAGKSSHGARVTIDVEKVTF-VKHLQKSYETEEGKTVILEC--QTSHTVSTKWYHNK 964
A N G A + I TF + L+K+ + + V++EC Q S + W
Sbjct: 166 AENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD 225
Query: 965 KEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETSTMLVVKE-TIPEF 1019
+ + I+ +G D G C + E L VKE T E
Sbjct: 226 RAVRENKRIAILPDG---SLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIEL 282
Query: 1020 IRKLQDFEVKEKDVAILEVEINSETADVV--WERDGEIIKPKKNKYDFEK---RGHIRKL 1074
K + V E V + I+ + DV W G+ I ++ FE + L
Sbjct: 283 TPKRTELTVGESIVLNCKA-IHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADL 341
Query: 1075 YIRNTSVHDEGEYSC 1089
IRN + G Y C
Sbjct: 342 MIRNILLMHAGRYGC 356
Score = 60.1 bits (139), Expect = 9e-08
Identities = 96/452 (21%), Positives = 159/452 (35%), Gaps = 35/452 (7%)
Query: 1484 VEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXX 1543
VEK L + + + C G P+P W ++G L
Sbjct: 99 VEK-LNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQS 157
Query: 1544 XXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGD-EWLVTAVIEGIPPP 1602
Y+C+A N +G + S + I N+ K D E ++ +G P P
Sbjct: 158 DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 217
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
+ W K + +K I +RI +S KY N G++ + +L V
Sbjct: 218 TISWKKGDRAVRENKRIAILPDGS---LRILNASKSDEGKYVCRGENVFGSAEIIASLSV 274
Query: 1663 YDKPSKPEGPVIMREIS-RESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDR 1721
+ P++ E E++ ES+ + K + D L++T Y K +P I +
Sbjct: 275 KE-PTRIELTPKRTELTVGESIVLNCKA-IHDASLDVTFYWTLKGQP-----IDFEEEGG 327
Query: 1722 DVETYCIQKLNENCEYMFRVIAQNPVG-----FSEALESEPIVIKTALDVPSXXXXXXXX 1776
E+ I+ + + M R I G +S + + P
Sbjct: 328 HFES--IRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIV 385
Query: 1777 XXIDNESVYITWFPSEKNGGSPIIDYKVEIK-------QEGKKWKXXXXXXXXXARIQKL 1829
I + ++W P+ N SPI Y ++ + Q K A L
Sbjct: 386 EEITESTATLSWSPAADNH-SPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDL 444
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKW--- 1886
+ Y+FR+ A N IGT P T I + + P + P N + + W
Sbjct: 445 NPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAV-PKTAPTNVSGRSGRRHELVIAWEPV 503
Query: 1887 TEPESNGGSPITNYIIEFKTVKGKSW-TKIVT 1917
+E NG YI+ F+ + W K+VT
Sbjct: 504 SEEFQNGEG--FGYIVAFRPNGTRGWKEKMVT 533
Score = 55.2 bits (127), Expect = 2e-06
Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 7/96 (7%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +VEKL GS +++EC+ G PRP W + + P +M L+
Sbjct: 96 PHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVN-----GVLM 150
Query: 570 IREVFPEDAGTFTCVAKNAAG--FASSTTELIVEAP 603
I V DAG + C+A+N G +AS+ +++ AP
Sbjct: 151 IHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP 186
Score = 51.2 bits (117), Expect = 4e-05
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 15/177 (8%)
Query: 1865 PPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTV----GG 1920
PP P +V E T + TL W+ P ++ SPI++Y ++ ++ W + TV G
Sbjct: 376 PPGPPGIVIVEEITESTATLSWS-PAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 434
Query: 1921 SVHEHCIENIKEKDEIIFRISAENTVGVSLP-TESQSVRLEKHATVPSPPTAPLEI--RM 1977
+ ++ E FR+ A N +G P T S+ +R + P TAP + R
Sbjct: 435 DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAV----PKTAPTNVSGRS 490
Query: 1978 VGSNIVMTSWG--TPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLS 2032
+ ++ +W + E+ G GY +A R W E KF RD S
Sbjct: 491 GRRHELVIAWEPVSEEFQNGEG-FGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDES 546
Score = 38.7 bits (86), Expect = 0.23
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV+ EC G P P ITW + I + + A L I V +DAG + C
Sbjct: 21 GTTVKMECFALGNPVPTITWMKVNGYIPSKARLR-----KSQAVLEIPNVQLDDAGIYEC 75
Query: 584 VAKNAAGFASSTTELIV 600
A+N+ G S +L V
Sbjct: 76 RAENSRGKNSFRGQLQV 92
Score = 35.9 bits (79), Expect = 1.6
Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 8/91 (8%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAK 586
V EC+ +G P+P I+W + ++ ++ + D +L I D G + C +
Sbjct: 205 VVIECKPQGSPKPTISWKKGDRAVRENKRIAILPD----GSLRILNASKSDEGKYVCRGE 260
Query: 587 NAAGFASSTTELIVEAP----LSDHGSEMTV 613
N G A L V+ P L+ +E+TV
Sbjct: 261 NVFGSAEIIASLSVKEPTRIELTPKRTELTV 291
>AY877349-1|AAX70929.1| 1463|Homo sapiens cardiac peroxidase
protein.
Length = 1463
Score = 95.1 bits (226), Expect = 2e-18
Identities = 76/318 (23%), Positives = 133/318 (41%), Gaps = 20/318 (6%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P + +P+ V G+ + CR P+P+I W+ + +++ + + D
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDD-----G 288
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N ++ +G Y +A N GEA + +L+ + +P VI+P + ++ G S
Sbjct: 289 TLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVL-IGTST 347
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
L G+P P ITW ++N L T S L+ +D G +T A NS G
Sbjct: 348 TLECMATGHPHPLITWTRDNG--LELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHG 405
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEI 872
+ +A I V+ P + P ++ V E+ ++ + NP P I W +
Sbjct: 406 TVQAAANIIVQAPPQFTVTP-------KDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQ 458
Query: 873 ISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVK 932
+ T G L I ++ D G Y+C A +S G ++T+ + +
Sbjct: 459 LPVEGQHTVLSSG---TLRIDRA-AQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFT 514
Query: 933 HLQKSYETEEGKTVILEC 950
L + E GK + + C
Sbjct: 515 QLPQDTSVEVGKNINISC 532
Score = 80.6 bits (190), Expect = 6e-14
Identities = 95/383 (24%), Positives = 149/383 (38%), Gaps = 36/383 (9%)
Query: 818 AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
A +TVEE N + P Q++ V T+ R NP P I W NN + +
Sbjct: 222 ASVTVEE---FNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLED 278
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKS---SHGARVTIDVEKVTFVKHL 934
N + L+I N E D G Y+C+A NSAG++ S R + K +FV
Sbjct: 279 DTRLNVFDDG-TLMIRNT-RESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQP 336
Query: 935 QKSYETEEGKTVILECQTS---HTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXX 991
Q + E G + LEC + H + T N E+ G H
Sbjct: 337 QDT-EVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRH-----VATSSGLYLQNITQ 390
Query: 992 XDVGVIKCIVKDQETSTML---VVKETIPEFIRKLQDFEVKEKDVA--ILEVEINSETAD 1046
D G C + + ++ + P+F +D V E+ + E + N
Sbjct: 391 RDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPV- 449
Query: 1047 VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC----ILRDESCTAEVTV 1102
+VW + G + P + ++ G +R I + HD+G+Y C L + + ++TV
Sbjct: 450 IVWTKTGGQL-PVEGQHTVLSSGTLR---IDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
Query: 1103 VELPPEIITRL-QNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKK 1160
+ T+L Q+ V G + ++ W K+G +I S + +G
Sbjct: 506 KPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEG-- 563
Query: 1161 QKLKIYDCDLDDAGEYSCEVGNS 1183
L IYD D G Y C NS
Sbjct: 564 -TLTIYDAGFPDQGRYECVARNS 585
Score = 70.1 bits (164), Expect = 8e-11
Identities = 73/283 (25%), Positives = 115/283 (40%), Gaps = 28/283 (9%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P+F +P+ V G+ LEC P P I W + + D + VA S +++
Sbjct: 330 PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWT-RDNGLELDGSRHVATSSGLYLQ-- 386
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
N+ + G +T A N G + ++ PPQ K +V + +V
Sbjct: 387 -----NITQRDHGRFTCHANNSHGTVQAAANIIVQA----PPQFTVTPKDQVVLEEHAVE 437
Query: 754 LSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVK--DEGVYTLKAENSE 811
+ GNP P I W K LP + S L+ + D+G Y +A +S
Sbjct: 438 WLCEADGNPPPVIVWTKTGGQ---LPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSL 494
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
G+ + S +TV+ +F Q+ +V+ I + P P ITW N E
Sbjct: 495 GVKKVSVQLTVKPKALA-----VFTQLPQDTSVEVGKNINISCHAQGEPQPIITW--NKE 547
Query: 872 IISPSETITQNFDGENIELVITNVDSEI-DSGDYKCVASNSAG 913
+ +E+ + D E +T D+ D G Y+CVA NS G
Sbjct: 548 GVQITESGKFHVDDEG---TLTIYDAGFPDQGRYECVARNSFG 587
Score = 68.9 bits (161), Expect = 2e-10
Identities = 43/167 (25%), Positives = 72/167 (43%), Gaps = 9/167 (5%)
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
L C+ G P P +TW RD + C A N HG V+
Sbjct: 349 LECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQ 408
Query: 1561 TSCVVGIQQKPVITISNED--IKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + +Q P T++ +D + ++H V EWL A +G PPP ++W K G +L + +
Sbjct: 409 AAANIIVQAPPQFTVTPKDQVVLEEHAV--EWLCEA--DGNPPPVIVWTKTGGQLPVEGQ 464
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
+ + + + +RI + +Y +A ++ G V V L V K
Sbjct: 465 HTVLS---SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPK 508
Score = 67.3 bits (157), Expect = 6e-10
Identities = 78/369 (21%), Positives = 140/369 (37%), Gaps = 24/369 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKAL-PTKSDGDTHSITI 791
+ P++ + + V G +V + + GNP+P I W NN + T+ + +
Sbjct: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM 291
Query: 792 LKPKKVKDEGVYTLKAENSEGIAET-SAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
++ + D+GVY A NS G A+T SA++ + P F+ + Q+ V +
Sbjct: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAK----PSFVIQPQDTEVLIGTST 347
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
L T +P P ITW R+N + G L + N+ ++ D G + C A+N
Sbjct: 348 TLECMATGHPHPLITWTRDNGLELDGSRHVATSSG----LYLQNI-TQRDHGRFTCHANN 402
Query: 911 SAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGM 970
S G A + + V + E + E + W ++
Sbjct: 403 SHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
Query: 971 DHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD----QETSTMLVVK-ETIPEFIRKLQD 1025
++ G D G +C ++ S L VK + + F + QD
Sbjct: 463 GQHTVLSSG---TLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQD 519
Query: 1026 FEVKEKDVAILEVEINSETADVV-WERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDE 1084
V+ + E ++ W ++G I + K+ + G L I + D+
Sbjct: 520 TSVEVGKNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEG---TLTIYDAGFPDQ 575
Query: 1085 GEYSCILRD 1093
G Y C+ R+
Sbjct: 576 GRYECVARN 584
Score = 64.1 bits (149), Expect = 5e-09
Identities = 57/217 (26%), Positives = 85/217 (39%), Gaps = 11/217 (5%)
Query: 606 DHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDI 665
DHG T A+I+ PP F+ PK Q V E + C P P I
Sbjct: 392 DHG-RFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVI 450
Query: 666 AWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVL 725
W G ++ P E + S L+I + +G Y AV+ G + + L
Sbjct: 451 VWTKTGGQL-PVEGQHTVLSS------GTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQL 503
Query: 726 KIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGD 785
+K K + + V G+++ +S G P+P ITW K + D
Sbjct: 504 TVK--PKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDD 561
Query: 786 THSITILKPKKVKDEGVYTLKAENSEGIAETSAVITV 822
++TI D+G Y A NS G+A T+ +TV
Sbjct: 562 EGTLTIY-DAGFPDQGRYECVARNSFGLAVTNMFLTV 597
Score = 59.7 bits (138), Expect = 1e-07
Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 2/78 (2%)
Query: 522 PDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
P G+TV F C+ EG P+P+I W + D ++ DD TL+IR D G +
Sbjct: 246 PSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDD--GTLMIRNTRESDQGVY 303
Query: 582 TCVAKNAAGFASSTTELI 599
C+A+N+AG A + + ++
Sbjct: 304 QCMARNSAGEAKTQSAML 321
Score = 56.0 bits (129), Expect = 1e-06
Identities = 73/403 (18%), Positives = 152/403 (37%), Gaps = 19/403 (4%)
Query: 1264 CEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
CEY L ++ + VE P+I ++ + G+ V + P+P WI
Sbjct: 210 CEYPR-RLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWI 268
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPS 1382
N+ + T+ ++ +L I+ +D G+Y+ N+ G A + +L S
Sbjct: 269 HNNHSLDLEDDTRLNVFD-DGTLMIRNTRESDQGVYQCMARNSAGEAKTQS--AMLRYSS 325
Query: 1383 PPGKPN-ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNI-TKTQTSI 1440
P KP+ +++ + + I + + ++ + + E +++ T + +
Sbjct: 326 LPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYL 385
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
QN+ RF +A N A+ +I + Q P + E + +E
Sbjct: 386 QNITQRDHGRFTCHANNSHGTVQAAAN-----IIVQAPPQFTVT--PKDQVVLEEHA-VE 437
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKT-AKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
C G P P + W + G +L + T + Y+C A + G
Sbjct: 438 WLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVK 497
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
+ S + ++ K + + +VG ++ +G P P + W K G ++ ++
Sbjct: 498 KVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKF 557
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++ + + I + +Y A N+ G + + L V
Sbjct: 558 HV---DDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
Score = 54.0 bits (124), Expect = 6e-06
Identities = 46/221 (20%), Positives = 86/221 (38%), Gaps = 15/221 (6%)
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-- 1531
++E QSP + +++ + TC G P+P++ W + L T N
Sbjct: 226 VEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVF 285
Query: 1532 -RXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVV----GIQQKPVITISNEDIKQKHKV 1586
Y+C+A N GE +T + + KP I +D + +
Sbjct: 286 DDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEV--LI 343
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + + G P P + W ++ N LE D ++ T +S + ++ + + ++T
Sbjct: 344 GTSTTLECMATGHPHPLITWTRD-NGLELDGSRHVAT---SSGLYLQNITQRDHGRFTCH 399
Query: 1647 ASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEW 1687
A+N+ GT + V P P ++ E +EW
Sbjct: 400 ANNSHGTVQAAANIIVQAPPQFTVTP--KDQVVLEEHAVEW 438
Score = 52.4 bits (120), Expect = 2e-05
Identities = 74/397 (18%), Positives = 155/397 (39%), Gaps = 37/397 (9%)
Query: 1182 NSKCTAILTVEE-----PSINFTLRLPEFILVPANTDAYLTVEIPDETL-DVTWYKKKSV 1235
+ + A +TVEE P I F P+ + VP+ Y T ++ W
Sbjct: 217 HGRAVASVTVEEFNCQSPRITFE---PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHS 273
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEF-----PPKI 1290
+ D E T ++ TL+IR E DQ Y C+ ++ K + ++ + P
Sbjct: 274 L-DLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSF 332
Query: 1291 VDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKI-IKKCKHTKPSIDSKSASLTIKK 1349
V ++ + G+ TL P P W ++ + + +H + S+ L ++
Sbjct: 333 VIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHV-----ATSSGLYLQN 387
Query: 1350 VENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKP-NILEIDSSSIN-ICWDEPENT 1407
+ D G + N+ G N+ + P P + + ++ ++ +C E
Sbjct: 388 ITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLC----EAD 443
Query: 1408 GN-STIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASE 1466
GN +I + ++ +V ++ I + ++ AV+ + + S
Sbjct: 444 GNPPPVIVWTKTGGQLPVEGQHTV--LSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVS- 500
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKL-KTA 1525
++ + K + + P ++ + E ++I ++C G PQP +TW ++G ++ ++
Sbjct: 501 ----VQLTVKPKALAVFTQLP-QDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESG 555
Query: 1526 KATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETS 1562
K ++ Y+C+A N G T+
Sbjct: 556 KFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTN 592
Score = 46.8 bits (106), Expect = 9e-04
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 5/94 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P FV + + G++ EC G+P P ITW R + D + + L
Sbjct: 330 PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL---ELDGSRHVATSS--GLY 384
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
++ + D G FTC A N+ G + +IV+AP
Sbjct: 385 LQNITQRDHGRFTCHANNSHGTVQAAANIIVQAP 418
Score = 46.8 bits (106), Expect = 9e-04
Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + C +G P+P ITW ++ I S F + D+ TL I + D G + C
Sbjct: 525 GKNINISCHAQGEPQPIITWNKEGVQITESGKFHV----DDEGTLTIYDAGFPDQGRYEC 580
Query: 584 VAKNAAGFASSTTELIVEA 602
VA+N+ G A + L V A
Sbjct: 581 VARNSFGLAVTNMFLTVTA 599
>BC098401-1|AAH98401.1| 771|Homo sapiens NRCAM protein protein.
Length = 771
Score = 94.7 bits (225), Expect = 3e-18
Identities = 114/478 (23%), Positives = 194/478 (40%), Gaps = 48/478 (10%)
Query: 507 SMAPIFV-EKLRPKHTPDGSTVQFECQVE-GYPRPQITWFRQTAIIKP-SQDFQMYYDDD 563
S +P++ EKL P G ++ C+ G P P I W + P S+ + D
Sbjct: 136 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGD 195
Query: 564 NVATLVIREVFPEDAGT-FTCVAK-NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
L V PED + C A+ N + V+ D ++ T+
Sbjct: 196 ----LYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELND-TIAANLSDTE 250
Query: 622 XXXXADILEGIPPTF-SKKPKAQYVDE--GSDILLECRLVAIPEPDIAWLFKGEEIVPDE 678
E PPTF + + A +E G+ + LEC +P P I W K + ++P +
Sbjct: 251 FYGAKSSRER-PPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWA-KEDGMLP-K 307
Query: 679 NISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
N +V + L+I +V + G Y +A N G I +++K P I
Sbjct: 308 NRTVYKNFE-----KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA----PYWI 358
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP----TKSDGDTHSITILKP 794
+++++ GE L + GNP+P I+W N P++ P K DGDT I
Sbjct: 359 TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDT---IIFSN 415
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-TVKEKGTIKLV 853
+ + VY A N G +A + V AEPP + + V L
Sbjct: 416 VQERSSAVYQCNASNEYGYLLANAFVNV------LAEPPRILTPANTLYQVIANRPALLD 469
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+P+P+I W++ + + E I + +E+ + DS +G Y CVA N G
Sbjct: 470 CAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDS---TGTYTCVARNKLG 526
Query: 914 KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH----TVSTKWYHNKKEI 967
+ + V ++++ T++ + + G V EC+ H +++ W + +E+
Sbjct: 527 MAKN--EVHLEIKDATWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL 582
Score = 81.8 bits (193), Expect = 2e-14
Identities = 132/623 (21%), Positives = 249/623 (39%), Gaps = 71/623 (11%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 39 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 98
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 99 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 155
Query: 751 SVILSAQ-VVGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 156 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 212
Query: 804 TLKAENSEGIAE----TSAVITVEE----------PTE------ENAEPPLFINRFQEIT 843
+ +++ I + + VI+V+E TE PP F+ +
Sbjct: 213 YARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNAS 272
Query: 844 VKE--KGTIKLVARVTRN-PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEID 900
KE +G + + + P P I W + + ++ + T+ +NF+ + ++++ SE D
Sbjct: 273 NKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-KTLQIIHV---SEAD 328
Query: 901 SGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKW 960
SG+Y+C+A N+ G H V + E T+I + W
Sbjct: 329 SGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISW 388
Query: 961 YHN--KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKE 1014
N EI+ D I +G V +C ++ + + V
Sbjct: 389 LTNGVPIEIAPDDPSRKI-DGDTIIFSNVQERSS--AVYQCNASNEYGYLLANAFVNVLA 445
Query: 1015 TIPEFIRKLQD-FEVKEKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
P + ++V A+L+ S + W + + ++ Y + G
Sbjct: 446 EPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG--- 502
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTV-VELPPE--IITRLQNQKVNKGNKATFEIE 1129
L I G Y+C+ R++ A+ V +E+ I+ + + V +G+ +FE +
Sbjct: 503 TLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDATWIVKQPEYAVVQRGSMVSFECK 562
Query: 1130 LTKGDAL---VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS--- 1183
+ L V W KD E+ + T+D K L + D DD+G Y+C +
Sbjct: 563 VKHDHTLSLTVLWLKDNRELPSDE--RFTVD--KDHLVVADVSDDDSGTYTCVANTTLDS 618
Query: 1184 -KCTAILT-VEEPSINFTLRLPE 1204
+A+L+ V+ P+ F L L +
Sbjct: 619 VSASAVLSVVDVPNPPFDLELTD 641
Score = 79.4 bits (187), Expect = 1e-13
Identities = 95/423 (22%), Positives = 171/423 (40%), Gaps = 41/423 (9%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXX 1545
+N+ P ED L C G P+P+++W +G ++ A +
Sbjct: 362 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSS 421
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C A N++G + + V + +P ++ + + L+ G P P +
Sbjct: 422 AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIE 481
Query: 1606 WYK--NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
W+K G+ L D I + + I ++ + YT A N G + EV L++
Sbjct: 482 WFKGAKGSALHED----IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK 537
Query: 1664 DKP---SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE--PDNNRWIKVAD 1718
D +PE V+ R V+ E K D L LT ++ + P + R+
Sbjct: 538 DATWIVKQPEYAVVQR---GSMVSFECKVK-HDHTLSLTVLWLKDNRELPSDERF----T 589
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXX 1778
VD+D + ++++ + +A + +++ + ++ + +DVP+
Sbjct: 590 VDKD--HLVVADVSDDDSGTYTCVANTTL---DSVSASAVL--SVVDVPNPPFDLELTDQ 642
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXARIQ-KLSINTT 1834
+D +SV ++W P + N SPI + +E + K W Q KLS
Sbjct: 643 LD-KSVQLSWTPGDDN-NSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVN 700
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP----E 1890
Y FR+ A N IG SLP + ++ + K P P S ++ + W +P E
Sbjct: 701 YSFRVMAVNSIGKSLPSEASEQY-LTKASEPDKNPTAVEGLGSEPDNLVITW-KPLNGFE 758
Query: 1891 SNG 1893
SNG
Sbjct: 759 SNG 761
Score = 71.3 bits (167), Expect = 3e-11
Identities = 108/467 (23%), Positives = 183/467 (39%), Gaps = 41/467 (8%)
Query: 1044 TADVVWERDGEIIKPKKNKY-DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
T + W ++ ++ + Y +FEK L I + S D G Y CI ++ T+
Sbjct: 293 TPIIYWAKEDGMLPKNRTVYKNFEKT-----LQIIHVSEADSGNYQCIAKNALGAIHHTI 347
Query: 1103 ---VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFS-NHIQLTI 1156
V+ P IT QN ++ G T I G+ R W +G I+ + + I
Sbjct: 348 SVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVPIEIAPDDPSRKI 406
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
DG + + + Y C N + +N L P IL PANT Y
Sbjct: 407 DG--DTIIFSNVQERSSAVYQCNASNEYGYLLANA---FVN-VLAEPPRILTPANT-LYQ 459
Query: 1217 TVEIPDETLDVTWYKKK-SVIE---DTEKFTLISDV----KKRTLIIRKCTEDDQCEYTC 1268
+ LD ++ IE + L D+ + TL I +D YTC
Sbjct: 460 VIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTC 519
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
V + K +V + + + EY + +RGS +V ++ + +D + + +
Sbjct: 520 VARNKLGMAKNEVHLEIKDATWIVKQPEYAVVQRGS----MVSFECKVK-HDHTLSLTVL 574
Query: 1328 IKKCKHTKPSIDSKSAS---LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
K PS + + L + V + D+G Y ++++D P+PP
Sbjct: 575 WLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPP 634
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWISVKNITKTQTSIQ- 1441
+ + S+ + W P + NS I +++EY++ W ++ TQT+ Q
Sbjct: 635 FDLELTDQLDKSVQLSW-TPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQL 693
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL 1488
L +Y FR AVN + S SE +E Y ++PT + L
Sbjct: 694 KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGL 740
Score = 57.6 bits (133), Expect = 5e-07
Identities = 63/290 (21%), Positives = 114/290 (39%), Gaps = 12/290 (4%)
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
PP P I +D+S + E + G + +Y+ E ++I TQT IQ
Sbjct: 168 PP--PIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQT-IQQ 224
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN---EDI 1499
+ S +N+ ++ S+T E+Y K ++ + PT P N + + +
Sbjct: 225 KQPISVKVISVDELNDTIAANLSDT-EFYGA-KSSRERPPTFLTPEGNASNKEELRGNVL 282
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L CI G+P P + W ++ L + Y+N Y+CIA N G
Sbjct: 283 SLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGA 342
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + V ++ P + +++ G++ + G P P + W NG +E +
Sbjct: 343 IHHTISVRVKAAPYWITAPQNLVL--SPGEDGTLICRANGNPKPRISWLTNGVPIEIAPD 400
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + K I ++ S+ Y ASN G + V +P +
Sbjct: 401 -DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPR 449
Score = 54.0 bits (124), Expect = 6e-06
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 4/122 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P+ P + +++ +SV L WT P + SPIT +IIE++ K W V G+
Sbjct: 631 PNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 689
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++ + FR+ A N++G SLP+E+ L K + PTA + N+V
Sbjct: 690 TAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLV 748
Query: 1984 MT 1985
+T
Sbjct: 749 IT 750
Score = 40.7 bits (91), Expect = 0.056
Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 8/92 (8%)
Query: 524 GSTVQFECQVEGYPRPQIT--WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V FEC+V+ +T W + + + F + D D+ LV+ +V +D+GT+
Sbjct: 554 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV--DKDH---LVVADVSDDDSGTY 608
Query: 582 TCVAKNAAGFASSTTEL-IVEAPLSDHGSEMT 612
TCVA S++ L +V+ P E+T
Sbjct: 609 TCVANTTLDSVSASAVLSVVDVPNPPFDLELT 640
>BC115736-1|AAI15737.1| 1192|Homo sapiens NRCAM protein protein.
Length = 1192
Score = 94.3 bits (224), Expect = 4e-18
Identities = 130/628 (20%), Positives = 253/628 (40%), Gaps = 55/628 (8%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 45 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 161
Query: 751 SVILSAQ-VVGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 162 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 218
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKE--KGTIKLVARVTRN- 859
+ +++ I + + + V PP F+ + KE +G + + +
Sbjct: 219 YARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGL 278
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P I W + + ++ + T+ +NF+ + ++++ SE DSG+Y+C+A N+ G H
Sbjct: 279 PTPIIYWAKEDGMLPKNRTVYKNFE-KTLQIIHV---SEADSGNYQCIAKNALGAIHHTI 334
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHN--KKEISGMDHREIIQ 977
V + E T+I + W N EI+ D I
Sbjct: 335 SVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKI- 393
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIRKLQD-FEVKEKD 1032
+G V +C ++ + + V P + ++V
Sbjct: 394 DGDTIIFSNVQERSS--AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANR 451
Query: 1033 VAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
A+L+ S + W + + ++ Y + G L I G Y+C+
Sbjct: 452 PALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG---TLEIPVAQKDSTGTYTCVA 508
Query: 1092 RDESCTAEVTV-VELPPE--IITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKDGSE 1145
R++ A+ V +E+ I+ + + V +G+ +FE ++ L V W KD E
Sbjct: 509 RNKLGMAKNEVHLEIKDATWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRE 568
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLR 1201
+ + T+D K L + D DD+G Y+C + +A+L+V P+
Sbjct: 569 LPSDE--RFTVD--KDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPT---PTP 621
Query: 1202 LPEFILVPANTDAYLTVEIPDETLDVTW 1229
P + + D LT ++ D+++ ++W
Sbjct: 622 APVYDVPNPPFDLELTDQL-DKSVQLSW 648
Score = 89.4 bits (212), Expect = 1e-16
Identities = 117/529 (22%), Positives = 207/529 (39%), Gaps = 53/529 (10%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXX 1545
+N+ P ED L C G P+P+++W +G ++ A +
Sbjct: 349 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSS 408
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C A N++G + + V + +P ++ + + L+ G P P +
Sbjct: 409 AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIE 468
Query: 1606 WYK--NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
W+K G+ L D I + + I ++ + YT A N G + EV L++
Sbjct: 469 WFKGAKGSALHED----IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK 524
Query: 1664 DKP---SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE--PDNNRWIKVAD 1718
D +PE V+ R V+ E K D L LT ++ + P + R+
Sbjct: 525 DATWIVKQPEYAVVQR---GSMVSFECKVK-HDHTLSLTVLWLKDNRELPSDERF----T 576
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT-----ALDVPSXXXXX 1773
VD+D + ++++ + +A + A +V T DVP+
Sbjct: 577 VDKD--HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDL 634
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXARIQ-KL 1829
+D +SV ++W P + N SPI + +E + K W Q KL
Sbjct: 635 ELTDQLD-KSVQLSWTPGDDN-NSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKL 692
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP 1889
S Y FR+ A N IG SLP + ++ + K P P S ++ + W +P
Sbjct: 693 SPYVNYSFRVMAVNSIGKSLPSEASEQY-LTKASEPDKNPTAVEGLGSEPDNLVITW-KP 750
Query: 1890 ----ESNGGSPITNYIIEFKTVKG-KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
ESNG P Y + ++ G WT +V +V ++ + + ++ A N
Sbjct: 751 LNGFESNG--PGLQYKVSWRQKDGDDEWTSVVV--ANVSKYIVSGTPTFVPYLIKVQALN 806
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+G + + + H+ P AP +R+ N+V ++ WD
Sbjct: 807 DMGFA----PEPAVVMGHSGEDLPMVAPGNVRV---NVVNSTLAEVHWD 848
Score = 78.6 bits (185), Expect = 2e-13
Identities = 208/1015 (20%), Positives = 374/1015 (36%), Gaps = 111/1015 (10%)
Query: 827 EENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI--ISPSETITQN- 882
E+ +PP + ++ + + I + P PS +W RN I +T
Sbjct: 40 EDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP 99
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
G I +++ +E G Y+C A N G + V + K + +
Sbjct: 100 GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQS 159
Query: 943 GKTVILECQTSHTVSTK---WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV-IK 998
G++++L C+ + W N + E + +G D
Sbjct: 160 GQSLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVLPEDTREDYI 217
Query: 999 CIVKDQETSTM-----LVVK--------ETIPEFIRKLQDFEVKEKDVA-ILEVEINSE- 1043
C + T T+ + VK E P F+ + KE+ +L +E +E
Sbjct: 218 CYARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEG 277
Query: 1044 --TADVVWERDGEIIKPKKNKY-DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
T + W ++ ++ + Y +FEK L I + S D G Y CI ++
Sbjct: 278 LPTPIIYWAKEDGMLPKNRTVYKNFEKT-----LQIIHVSEADSGNYQCIAKNALGAIHH 332
Query: 1101 TV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFS-NHIQL 1154
T+ V+ P IT QN ++ G T I G+ R W +G I+ + +
Sbjct: 333 TISVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVPIEIAPDDPSR 391
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
IDG + + + Y C N + +N L P IL PANT
Sbjct: 392 KIDG--DTIIFSNVQERSSAVYQCNASNEYGYLLANA---FVN-VLAEPPRILTPANT-L 444
Query: 1215 YLTVEIPDETLDVTWYKKK-SVIE---DTEKFTLISDV----KKRTLIIRKCTEDDQCEY 1266
Y + LD ++ IE + L D+ + TL I +D Y
Sbjct: 445 YQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTY 504
Query: 1267 TCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVNS 1325
TCV + K +V + + + EY + +RGS +V ++ + +D + +
Sbjct: 505 TCVARNKLGMAKNEVHLEIKDATWIVKQPEYAVVQRGS----MVSFECKVK-HDHTLSLT 559
Query: 1326 KIIKKCKHTKPSIDSKSAS---LTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL---- 1378
+ K PS + + L + V + D+G Y ++++
Sbjct: 560 VLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTP 619
Query: 1379 ------DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISV 1430
D P+PP + + S+ + W P + NS I +++EY++ W
Sbjct: 620 TPAPVYDVPNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQ 678
Query: 1431 KNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
++ TQT+ Q L +Y FR AVN + S SE +E Y ++PT + L
Sbjct: 679 TEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLG 738
Query: 1490 N------ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXX 1543
+ IT +P E G Q KV+W + + N
Sbjct: 739 SEPDNLVITWKPLNGFESN---GPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTF 795
Query: 1544 XXXXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPP 1602
K A ND G E + V+G + + ++ +++ V + L + +P
Sbjct: 796 VPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRV--NVVNSTLAEVHWDPVPLK 853
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSV---IRIKELKRSHS--------SKYTIEASNTA 1651
+ + G ++ K + + + + + I + ++H S YT+
Sbjct: 854 SIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVN 913
Query: 1652 GTSSVEVTL-KVYDKP-SKPEGPVIMREI--SRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
G + +V++ P P P ++ + + +S+T+EW PP G+ LT+Y + K++
Sbjct: 914 GKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGI-LTEYTL-KYQ 971
Query: 1708 PDNNRWIKVADVDRDVET----YCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
P N+ VD + + ++ LN + Y F AQ G + E +
Sbjct: 972 PINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAV 1026
Score = 65.3 bits (152), Expect = 2e-09
Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 8/191 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P+ P + +++ +SV L WT P + SPIT +IIE++ K W V G+
Sbjct: 628 PNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 686
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++ + FR+ A N++G SLP+E+ L K + PTA + N+V
Sbjct: 687 TAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLV 745
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+T ++ P L Y ++ R W V V N K+ + Y+I++
Sbjct: 746 ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSV--VVANVSKYIVSGTPTFVPYLIKVQ 803
Query: 2043 ARNEIGLS-EP 2052
A N++G + EP
Sbjct: 804 ALNDMGFAPEP 814
Score = 46.4 bits (105), Expect = 0.001
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 479 NYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVE-KLRPKHTPDGSTVQFECQVEGYP 537
N+TQ +Q+K + I + V +S E+ + E K G+ + EC EG P
Sbjct: 223 NHTQTIQQK--QPIS-VKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 279
Query: 538 RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTE 597
P I W ++ ++ ++ ++ TL I V D+G + C+AKNA G T
Sbjct: 280 TPIIYWAKEDGMLPKNRTVYKNFEK----TLQIIHVSEADSGNYQCIAKNALGAIHHTIS 335
Query: 598 LIVEA 602
+ V+A
Sbjct: 336 VRVKA 340
Score = 41.9 bits (94), Expect = 0.024
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 524 GSTVQFECQVEGYPRPQIT--WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V FEC+V+ +T W + + + F + D D+ LV+ +V +D+GT+
Sbjct: 541 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV--DKDH---LVVADVSDDDSGTY 595
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA S++ L V AP
Sbjct: 596 TCVANTTLDSVSASAVLSVVAP 617
Score = 41.1 bits (92), Expect = 0.042
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 7/109 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE----WISVK-NITK 1435
PS P I+ S+ + WD P + N + Y ++YQ I++T + +K K
Sbjct: 933 PSAPSSLKIVNPTLDSLTLEWDPPSHP-NGILTEYTLKYQPINSTHELGPLVDLKIPANK 991
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
T+ +++NL ++ Y+F YA S + T E + E I P V
Sbjct: 992 TRWTLKNLNFSTRYKFYFYAQTSAG-SGSQITEEAVTTVDEAGILPPDV 1039
Score = 39.5 bits (88), Expect = 0.13
Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 530 ECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAA 589
+C G P P I WF+ +D + +++ TL I + GT+TCVA+N
Sbjct: 456 DCAFFGSPLPTIEWFKGAKGSALHEDIYVLHEN---GTLEIPVAQKDSTGTYTCVARNKL 512
Query: 590 GFASSTTELIVE 601
G A + L ++
Sbjct: 513 GMAKNEVHLEIK 524
>BC114570-1|AAI14571.1| 1180|Homo sapiens NRCAM protein protein.
Length = 1180
Score = 94.3 bits (224), Expect = 4e-18
Identities = 130/628 (20%), Positives = 253/628 (40%), Gaps = 55/628 (8%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 45 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 161
Query: 751 SVILSAQ-VVGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 162 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 218
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKE--KGTIKLVARVTRN- 859
+ +++ I + + + V PP F+ + KE +G + + +
Sbjct: 219 YARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGL 278
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P I W + + ++ + T+ +NF+ + ++++ SE DSG+Y+C+A N+ G H
Sbjct: 279 PTPIIYWAKEDGMLPKNRTVYKNFE-KTLQIIHV---SEADSGNYQCIAKNALGAIHHTI 334
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHN--KKEISGMDHREIIQ 977
V + E T+I + W N EI+ D I
Sbjct: 335 SVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKI- 393
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIRKLQD-FEVKEKD 1032
+G V +C ++ + + V P + ++V
Sbjct: 394 DGDTIIFSNVQERSS--AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANR 451
Query: 1033 VAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
A+L+ S + W + + ++ Y + G L I G Y+C+
Sbjct: 452 PALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG---TLEIPVAQKDSTGTYTCVA 508
Query: 1092 RDESCTAEVTV-VELPPE--IITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKDGSE 1145
R++ A+ V +E+ I+ + + V +G+ +FE ++ L V W KD E
Sbjct: 509 RNKLGMAKNEVHLEIKDATWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRE 568
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLR 1201
+ + T+D K L + D DD+G Y+C + +A+L+V P+
Sbjct: 569 LPSDE--RFTVD--KDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPT---PTP 621
Query: 1202 LPEFILVPANTDAYLTVEIPDETLDVTW 1229
P + + D LT ++ D+++ ++W
Sbjct: 622 APVYDVPNPPFDLELTDQL-DKSVQLSW 648
Score = 89.4 bits (212), Expect = 1e-16
Identities = 117/529 (22%), Positives = 207/529 (39%), Gaps = 53/529 (10%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXX 1545
+N+ P ED L C G P+P+++W +G ++ A +
Sbjct: 349 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSS 408
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C A N++G + + V + +P ++ + + L+ G P P +
Sbjct: 409 AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIE 468
Query: 1606 WYK--NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
W+K G+ L D I + + I ++ + YT A N G + EV L++
Sbjct: 469 WFKGAKGSALHED----IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK 524
Query: 1664 DKP---SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE--PDNNRWIKVAD 1718
D +PE V+ R V+ E K D L LT ++ + P + R+
Sbjct: 525 DATWIVKQPEYAVVQR---GSMVSFECKVK-HDHTLSLTVLWLKDNRELPSDERF----T 576
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT-----ALDVPSXXXXX 1773
VD+D + ++++ + +A + A +V T DVP+
Sbjct: 577 VDKD--HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDL 634
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXARIQ-KL 1829
+D +SV ++W P + N SPI + +E + K W Q KL
Sbjct: 635 ELTDQLD-KSVQLSWTPGDDN-NSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKL 692
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP 1889
S Y FR+ A N IG SLP + ++ + K P P S ++ + W +P
Sbjct: 693 SPYVNYSFRVMAVNSIGKSLPSEASEQY-LTKASEPDKNPTAVEGLGSEPDNLVITW-KP 750
Query: 1890 ----ESNGGSPITNYIIEFKTVKG-KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
ESNG P Y + ++ G WT +V +V ++ + + ++ A N
Sbjct: 751 LNGFESNG--PGLQYKVSWRQKDGDDEWTSVVV--ANVSKYIVSGTPTFVPYLIKVQALN 806
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+G + + + H+ P AP +R+ N+V ++ WD
Sbjct: 807 DMGFA----PEPAVVMGHSGEDLPMVAPGNVRV---NVVNSTLAEVHWD 848
Score = 78.6 bits (185), Expect = 2e-13
Identities = 208/1015 (20%), Positives = 374/1015 (36%), Gaps = 111/1015 (10%)
Query: 827 EENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI--ISPSETITQN- 882
E+ +PP + ++ + + I + P PS +W RN I +T
Sbjct: 40 EDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP 99
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
G I +++ +E G Y+C A N G + V + K + +
Sbjct: 100 GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQS 159
Query: 943 GKTVILECQTSHTVSTK---WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV-IK 998
G++++L C+ + W N + E + +G D
Sbjct: 160 GQSLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVLPEDTREDYI 217
Query: 999 CIVKDQETSTM-----LVVK--------ETIPEFIRKLQDFEVKEKDVA-ILEVEINSE- 1043
C + T T+ + VK E P F+ + KE+ +L +E +E
Sbjct: 218 CYARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEG 277
Query: 1044 --TADVVWERDGEIIKPKKNKY-DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
T + W ++ ++ + Y +FEK L I + S D G Y CI ++
Sbjct: 278 LPTPIIYWAKEDGMLPKNRTVYKNFEKT-----LQIIHVSEADSGNYQCIAKNALGAIHH 332
Query: 1101 TV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFS-NHIQL 1154
T+ V+ P IT QN ++ G T I G+ R W +G I+ + +
Sbjct: 333 TISVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVPIEIAPDDPSR 391
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
IDG + + + Y C N + +N L P IL PANT
Sbjct: 392 KIDG--DTIIFSNVQERSSAVYQCNASNEYGYLLANA---FVN-VLAEPPRILTPANT-L 444
Query: 1215 YLTVEIPDETLDVTWYKKK-SVIE---DTEKFTLISDV----KKRTLIIRKCTEDDQCEY 1266
Y + LD ++ IE + L D+ + TL I +D Y
Sbjct: 445 YQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTY 504
Query: 1267 TCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVNS 1325
TCV + K +V + + + EY + +RGS +V ++ + +D + +
Sbjct: 505 TCVARNKLGMAKNEVHLEIKDATWIVKQPEYAVVQRGS----MVSFECKVK-HDHTLSLT 559
Query: 1326 KIIKKCKHTKPSIDSKSAS---LTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL---- 1378
+ K PS + + L + V + D+G Y ++++
Sbjct: 560 VLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTP 619
Query: 1379 ------DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISV 1430
D P+PP + + S+ + W P + NS I +++EY++ W
Sbjct: 620 TPAPVYDVPNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQ 678
Query: 1431 KNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
++ TQT+ Q L +Y FR AVN + S SE +E Y ++PT + L
Sbjct: 679 TEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLG 738
Query: 1490 N------ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXX 1543
+ IT +P E G Q KV+W + + N
Sbjct: 739 SEPDNLVITWKPLNGFESN---GPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTF 795
Query: 1544 XXXXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPP 1602
K A ND G E + V+G + + ++ +++ V + L + +P
Sbjct: 796 VPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRV--NVVNSTLAEVHWDPVPLK 853
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSV---IRIKELKRSHS--------SKYTIEASNTA 1651
+ + G ++ K + + + + + I + ++H S YT+
Sbjct: 854 SIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVN 913
Query: 1652 GTSSVEVTL-KVYDKP-SKPEGPVIMREI--SRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
G + +V++ P P P ++ + + +S+T+EW PP G+ LT+Y + K++
Sbjct: 914 GKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGI-LTEYTL-KYQ 971
Query: 1708 PDNNRWIKVADVDRDVET----YCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
P N+ VD + + ++ LN + Y F AQ G + E +
Sbjct: 972 PINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAV 1026
Score = 65.3 bits (152), Expect = 2e-09
Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 8/191 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P+ P + +++ +SV L WT P + SPIT +IIE++ K W V G+
Sbjct: 628 PNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 686
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++ + FR+ A N++G SLP+E+ L K + PTA + N+V
Sbjct: 687 TAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLV 745
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+T ++ P L Y ++ R W V V N K+ + Y+I++
Sbjct: 746 ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSV--VVANVSKYIVSGTPTFVPYLIKVQ 803
Query: 2043 ARNEIGLS-EP 2052
A N++G + EP
Sbjct: 804 ALNDMGFAPEP 814
Score = 46.4 bits (105), Expect = 0.001
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 479 NYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVE-KLRPKHTPDGSTVQFECQVEGYP 537
N+TQ +Q+K + I + V +S E+ + E K G+ + EC EG P
Sbjct: 223 NHTQTIQQK--QPIS-VKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 279
Query: 538 RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTE 597
P I W ++ ++ ++ ++ TL I V D+G + C+AKNA G T
Sbjct: 280 TPIIYWAKEDGMLPKNRTVYKNFEK----TLQIIHVSEADSGNYQCIAKNALGAIHHTIS 335
Query: 598 LIVEA 602
+ V+A
Sbjct: 336 VRVKA 340
Score = 41.9 bits (94), Expect = 0.024
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 524 GSTVQFECQVEGYPRPQIT--WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V FEC+V+ +T W + + + F + D D+ LV+ +V +D+GT+
Sbjct: 541 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV--DKDH---LVVADVSDDDSGTY 595
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA S++ L V AP
Sbjct: 596 TCVANTTLDSVSASAVLSVVAP 617
Score = 39.5 bits (88), Expect = 0.13
Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 530 ECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAA 589
+C G P P I WF+ +D + +++ TL I + GT+TCVA+N
Sbjct: 456 DCAFFGSPLPTIEWFKGAKGSALHEDIYVLHEN---GTLEIPVAQKDSTGTYTCVARNKL 512
Query: 590 GFASSTTELIVE 601
G A + L ++
Sbjct: 513 GMAKNEVHLEIK 524
>AB002341-1|BAA20801.2| 1187|Homo sapiens KIAA0343 protein.
Length = 1187
Score = 94.3 bits (224), Expect = 4e-18
Identities = 130/628 (20%), Positives = 253/628 (40%), Gaps = 55/628 (8%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 52 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 111
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 112 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 168
Query: 751 SVILSAQ-VVGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 169 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 225
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKE--KGTIKLVARVTRN- 859
+ +++ I + + + V PP F+ + KE +G + + +
Sbjct: 226 YARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGL 285
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P I W + + ++ + T+ +NF+ + ++++ SE DSG+Y+C+A N+ G H
Sbjct: 286 PTPIIYWAKEDGMLPKNRTVYKNFE-KTLQIIHV---SEADSGNYQCIAKNALGAIHHTI 341
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHN--KKEISGMDHREIIQ 977
V + E T+I + W N EI+ D I
Sbjct: 342 SVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKI- 400
Query: 978 EGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIRKLQD-FEVKEKD 1032
+G V +C ++ + + V P + ++V
Sbjct: 401 DGDTIIFSNVQERSS--AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANR 458
Query: 1033 VAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
A+L+ S + W + + ++ Y + G L I G Y+C+
Sbjct: 459 PALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG---TLEIPVAQKDSTGTYTCVA 515
Query: 1092 RDESCTAEVTV-VELPPE--IITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKDGSE 1145
R++ A+ V +E+ I+ + + V +G+ +FE ++ L V W KD E
Sbjct: 516 RNKLGMAKNEVHLEIKDATWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRE 575
Query: 1146 IQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS----KCTAILTVEEPSINFTLR 1201
+ + T+D K L + D DD+G Y+C + +A+L+V P+
Sbjct: 576 LPSDE--RFTVD--KDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPT---PTP 628
Query: 1202 LPEFILVPANTDAYLTVEIPDETLDVTW 1229
P + + D LT ++ D+++ ++W
Sbjct: 629 APVYDVPNPPFDLELTDQL-DKSVQLSW 655
Score = 87.4 bits (207), Expect = 5e-16
Identities = 116/529 (21%), Positives = 206/529 (38%), Gaps = 53/529 (10%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXX 1545
+N+ P ED L C G P+P+++W +G ++ A +
Sbjct: 356 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSS 415
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C A N++G + + V + +P ++ + + L+ G P P +
Sbjct: 416 AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIE 475
Query: 1606 WYK--NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
W+K G+ L D I + + I ++ + YT A N G + EV L++
Sbjct: 476 WFKGAKGSALHED----IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK 531
Query: 1664 DKP---SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE--PDNNRWIKVAD 1718
D +PE V+ R V+ E K D L LT ++ + P + R+
Sbjct: 532 DATWIVKQPEYAVVQR---GSMVSFECKVK-HDHTLSLTVLWLKDNRELPSDERF----T 583
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT-----ALDVPSXXXXX 1773
VD+D + ++++ + +A + A +V T DVP+
Sbjct: 584 VDKD--HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDL 641
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXARIQ-KL 1829
+D +SV ++W P + N SPI + +E + K W Q L
Sbjct: 642 ELTDQLD-KSVQLSWTPGDDN-NSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLNL 699
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP 1889
S Y FR+ A N IG SLP + ++ + K P P S ++ + W +P
Sbjct: 700 SPYVNYSFRVMAVNSIGKSLPSEASEQY-LTKASEPDKNPTAVEGLGSEPDNLVITW-KP 757
Query: 1890 ----ESNGGSPITNYIIEFKTVKG-KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
ESNG P Y + ++ G WT +V +V ++ + + ++ A N
Sbjct: 758 LNGFESNG--PGLQYKVSWRQKDGDDEWTSVVV--ANVSKYIVSGTPTFVPYLIKVQALN 813
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+G + + + H+ P AP +R+ N+V ++ WD
Sbjct: 814 DMGFA----PEPAVVMGHSGEDLPMVAPGNVRV---NVVNSTLAEVHWD 855
Score = 81.0 bits (191), Expect = 4e-14
Identities = 209/1015 (20%), Positives = 375/1015 (36%), Gaps = 111/1015 (10%)
Query: 827 EENAEPPLFINRF-QEITVKEKGTIKLVARVTRNPVPSITWYRNNEI--ISPSETITQN- 882
E+ +PP + ++ + + I + P PS +W RN I +T
Sbjct: 47 EDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP 106
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEE 942
G I +++ +E G Y+C A N G + V + K + +
Sbjct: 107 GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQS 166
Query: 943 GKTVILECQTSHTVSTK---WYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV-IK 998
G++++L C+ + W N + E + +G D
Sbjct: 167 GQSLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVLPEDTREDYI 224
Query: 999 CIVKDQETSTM-----LVVK--------ETIPEFIRKLQDFEVKEKDVA-ILEVEINSE- 1043
C + T T+ + VK E P F+ + KE+ +L +E +E
Sbjct: 225 CYARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEG 284
Query: 1044 --TADVVWERDGEIIKPKKNKY-DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEV 1100
T + W ++ ++ + Y +FEK L I + S D G Y CI ++
Sbjct: 285 LPTPIIYWAKEDGMLPKNRTVYKNFEKT-----LQIIHVSEADSGNYQCIAKNALGAIHH 339
Query: 1101 TV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFS-NHIQL 1154
T+ V+ P IT QN ++ G T I G+ R W +G I+ + +
Sbjct: 340 TISVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVPIEIAPDDPSR 398
Query: 1155 TIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
IDG + + + Y C N + +N L P IL PANT
Sbjct: 399 KIDG--DTIIFSNVQERSSAVYQCNASNEYGYLLANA---FVN-VLAEPPRILTPANT-L 451
Query: 1215 YLTVEIPDETLDVTWYKKK-SVIE---DTEKFTLISDV----KKRTLIIRKCTEDDQCEY 1266
Y + LD ++ IE + L D+ + TL I +D Y
Sbjct: 452 YQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTY 511
Query: 1267 TCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVNS 1325
TCV + K +V + + + EY + +RGS +V ++ + +D + +
Sbjct: 512 TCVARNKLGMAKNEVHLEIKDATWIVKQPEYAVVQRGS----MVSFECKVK-HDHTLSLT 566
Query: 1326 KIIKKCKHTKPSIDSKSAS---LTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL---- 1378
+ K PS + + L + V + D+G Y ++++
Sbjct: 567 VLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTP 626
Query: 1379 ------DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISV 1430
D P+PP + + S+ + W P + NS I +++EY++ W
Sbjct: 627 TPAPVYDVPNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQ 685
Query: 1431 KNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
++ TQT+ Q NL +Y FR AVN + S SE +E Y ++PT + L
Sbjct: 686 TEVSGTQTTAQLNLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLG 745
Query: 1490 N------ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXX 1543
+ IT +P E G Q KV+W + + N
Sbjct: 746 SEPDNLVITWKPLNGFESN---GPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTF 802
Query: 1544 XXXXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPP 1602
K A ND G E + V+G + + ++ +++ V + L + +P
Sbjct: 803 VPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRV--NVVNSTLAEVHWDPVPLK 860
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSV---IRIKELKRSHS--------SKYTIEASNTA 1651
+ + G ++ K + + + + + I + ++H S YT+
Sbjct: 861 SIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVN 920
Query: 1652 GTSSVEVTL-KVYDKP-SKPEGPVIMREI--SRESVTIEWKPPLDDGGLELTKYAIEKHE 1707
G + +V++ P P P ++ + + +S+T+EW PP G+ LT+Y + K++
Sbjct: 921 GKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGI-LTEYTL-KYQ 978
Query: 1708 PDNNRWIKVADVDRDVET----YCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
P N+ VD + + ++ LN + Y F AQ G + E +
Sbjct: 979 PINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAV 1033
Score = 67.3 bits (157), Expect = 6e-10
Identities = 53/191 (27%), Positives = 87/191 (45%), Gaps = 8/191 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P+ P + +++ +SV L WT P + SPIT +IIE++ K W V G+
Sbjct: 635 PNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 693
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
+ N+ FR+ A N++G SLP+E+ L K + PTA + N+V
Sbjct: 694 TAQL-NLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLV 752
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+T ++ P L Y ++ R W V V N K+ + Y+I++
Sbjct: 753 ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSV--VVANVSKYIVSGTPTFVPYLIKVQ 810
Query: 2043 ARNEIGLS-EP 2052
A N++G + EP
Sbjct: 811 ALNDMGFAPEP 821
Score = 46.4 bits (105), Expect = 0.001
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 479 NYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVE-KLRPKHTPDGSTVQFECQVEGYP 537
N+TQ +Q+K + I + V +S E+ + E K G+ + EC EG P
Sbjct: 230 NHTQTIQQK--QPIS-VKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 286
Query: 538 RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTE 597
P I W ++ ++ ++ ++ TL I V D+G + C+AKNA G T
Sbjct: 287 TPIIYWAKEDGMLPKNRTVYKNFEK----TLQIIHVSEADSGNYQCIAKNALGAIHHTIS 342
Query: 598 LIVEA 602
+ V+A
Sbjct: 343 VRVKA 347
Score = 41.9 bits (94), Expect = 0.024
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 524 GSTVQFECQVEGYPRPQIT--WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V FEC+V+ +T W + + + F + D D+ LV+ +V +D+GT+
Sbjct: 548 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV--DKDH---LVVADVSDDDSGTY 602
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA S++ L V AP
Sbjct: 603 TCVANTTLDSVSASAVLSVVAP 624
Score = 39.5 bits (88), Expect = 0.13
Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 530 ECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAA 589
+C G P P I WF+ +D + +++ TL I + GT+TCVA+N
Sbjct: 463 DCAFFGSPLPTIEWFKGAKGSALHEDIYVLHEN---GTLEIPVAQKDSTGTYTCVARNKL 519
Query: 590 GFASSTTELIVE 601
G A + L ++
Sbjct: 520 GMAKNEVHLEIK 531
>U27266-1|AAB86737.1| 477|Homo sapiens myosin binding protein H
protein.
Length = 477
Score = 93.9 bits (223), Expect = 6e-18
Identities = 68/302 (22%), Positives = 136/302 (45%), Gaps = 21/302 (6%)
Query: 1282 EVVEFPP-KIVDYEREYRIKR-GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
E +E P ++ + R+ I++ G V L + +Q P+P W N + + + + D
Sbjct: 167 ENIEAPKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGD 226
Query: 1340 SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINI 1399
S L I+ + +D+G Y+L + A +++ +++KP PP +L++ + +
Sbjct: 227 QDSI-LFIRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPCCIRLLDVWGCNAAL 285
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
W P++TGN+ ++ Y+V+ + T +W +V + T +I +L +SY FR ++ N
Sbjct: 286 QWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSENL 345
Query: 1459 VDISDASETTEYYKVIKETKI-------------QSPTVEKPLKNITTEPNEDIELTCIF 1505
+S ++ T+ I++ I ++P+ +PL + T+ P +L C
Sbjct: 346 CGLSTSATVTKELAHIQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSV 405
Query: 1506 GGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
P+PK+ W ++ ++ K + + Y C A N GE
Sbjct: 406 RASPKPKIIWMKNKMEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASV 465
Query: 1562 SC 1563
C
Sbjct: 466 DC 467
Score = 70.1 bits (164), Expect = 8e-11
Identities = 43/167 (25%), Positives = 81/167 (48%), Gaps = 5/167 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VG+ + +G P P+ W NG+ L++ + ++ T ++ S++ I+ +RS S +Y
Sbjct: 187 QVGETVNLQIPFQGKPKPQATWTHNGHALDSQR-VSMRTGDQDSILFIRSAQRSDSGRYE 245
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+ + + + V +KP P + + ++ + ++W PP D G EL Y ++
Sbjct: 246 LTVRVEDLEAKAVIDILVIEKPGPP-CCIRLLDVWGCNAALQWTPPQDTGNTELLGYMVQ 304
Query: 1705 KHEPDNNRWIKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFS 1750
K + +W V ++R T C I L Y FRV ++N G S
Sbjct: 305 KADKKTGQWFTV--LERYHPTTCTISDLIIGNSYSFRVFSENLCGLS 349
Score = 59.7 bits (138), Expect = 1e-07
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 7/155 (4%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
D PS P + ++ SSS+ + W+ PE G + YV+E +EW +S + + T
Sbjct: 69 DVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGGSEWVPVSARPMMVT 128
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP---LKNITT 1493
Q +++NL + R AV + + + I++P + P +
Sbjct: 129 QQTVRNLALGDKFLLRVSAVRPAGAGPPAMLDQPIHI--RENIEAPKIRVPRHLRQTYIR 186
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT 1528
+ E + L F G P+P+ TW +G L + + +
Sbjct: 187 QVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVS 221
Score = 56.8 bits (131), Expect = 8e-07
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 4/114 (3%)
Query: 492 IDKLPVFEKPTS---EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
I K + KP + S AP F + L + G + Q C V P+P+I W +
Sbjct: 361 IQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKM 420
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
I+ + ++ + V TL IR+ P D+G +TC A N G AS L V+A
Sbjct: 421 EIQGNPKYRAL-SEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVKA 473
Score = 48.8 bits (111), Expect = 2e-04
Identities = 36/150 (24%), Positives = 62/150 (41%), Gaps = 4/150 (2%)
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR--EI 1678
+ T E + + E R + A T+S T P P+++ ++
Sbjct: 24 VPTAEPPGEVAVSESTREEQVPKPHGPAPQAPTAST-ATKPAPPSEDVPSAPLLLTLDDV 82
Query: 1679 SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYM 1738
S SVT+ W+PP G L L Y +E + W+ V+ V ++ L +++
Sbjct: 83 SSSSVTVSWEPPERLGRLGLQGYVLELCREGGSEWVPVSARPMMVTQQTVRNLALGDKFL 142
Query: 1739 FRVIAQNPVGFS-EALESEPIVIKTALDVP 1767
RV A P G A+ +PI I+ ++ P
Sbjct: 143 LRVSAVRPAGAGPPAMLDQPIHIRENIEAP 172
Score = 48.0 bits (109), Expect = 4e-04
Identities = 25/102 (24%), Positives = 43/102 (42%), Gaps = 1/102 (0%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
PS P + + +S SVT+ W PE G + Y++E G W + V +
Sbjct: 71 PSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGGSEWVPVSARPMMVTQQ 130
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVP 1966
+ N+ D+ + R+SA G P Q + + ++ P
Sbjct: 131 TVRNLALGDKFLLRVSAVRPAGAGPPAMLDQPIHIRENIEAP 172
Score = 43.6 bits (98), Expect = 0.008
Identities = 30/94 (31%), Positives = 40/94 (42%), Gaps = 4/94 (4%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSI 789
E P +PL G S L V +P+P I W KN ++ P S+ ++
Sbjct: 380 EAPSFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKMEIQGNPKYRALSEQGVCTL 439
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
I KP D GVYT KA N G A + V+
Sbjct: 440 EIRKPSPF-DSGVYTCKAINVLGEASVDCRLEVK 472
Score = 43.2 bits (97), Expect = 0.010
Identities = 65/299 (21%), Positives = 111/299 (37%), Gaps = 31/299 (10%)
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXX 1823
DVPS + + SV ++W P E+ G + Y +E+ +EG +W
Sbjct: 69 DVPSAPLLLTLDD-VSSSSVTVSWEPPERLGRLGLQGYVLELCREGGSEWVPVSARPMMV 127
Query: 1824 AR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS--QPRNFVVSESTS 1879
+ ++ L++ + R+ A G P D I I + + P PR+
Sbjct: 128 TQQTVRNLALGDKFLLRVSAVRPAGAGPPAMLDQPIHIRENIEAPKIRVPRH-------- 179
Query: 1880 RSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE-NIKEKDEIIF 1938
L+ T G + + K +WT G ++ + ++D I+F
Sbjct: 180 ----LRQTYIRQVGETVNLQIPFQGKPKPQATWTHN---GHALDSQRVSMRTGDQDSILF 232
Query: 1939 RISAENTVGVSLPTESQSVRLEKHATV-------PSPPTAPLEIRMVGSNIVMTSWGTPE 1991
SA+ + + LE A + P PP + + G N + W P+
Sbjct: 233 IRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPCCIRLLDVWGCNAAL-QWTPPQ 291
Query: 1992 WDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLS 2050
G LLGY + D W V + + I DL ++Y R+++ N GLS
Sbjct: 292 DTGNTELLGYMVQKADKKTGQWFTVLE-RYHPTTCTISDLIIGNSYSFRVFSENLCGLS 349
Score = 42.7 bits (96), Expect = 0.014
Identities = 18/67 (26%), Positives = 36/67 (53%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
+ P P++IW KN +++ + +Y +++ + I++ S YT +A N G +S
Sbjct: 405 VRASPKPKIIWMKNKMEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEAS 464
Query: 1656 VEVTLKV 1662
V+ L+V
Sbjct: 465 VDCRLEV 471
Score = 41.9 bits (94), Expect = 0.024
Identities = 29/106 (27%), Positives = 49/106 (46%), Gaps = 7/106 (6%)
Query: 1963 ATVPSPPT-----APLEIRM--VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWME 2015
AT P+PP+ APL + + V S+ V SW PE G L GY + + + W+
Sbjct: 60 ATKPAPPSEDVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGGSEWVP 119
Query: 2016 VGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
V + + +R+L+ +++R+ A G P D+P +
Sbjct: 120 VSARPMMVTQQTVRNLALGDKFLLRVSAVRPAGAGPPAMLDQPIHI 165
Score = 39.9 bits (89), Expect = 0.098
Identities = 29/99 (29%), Positives = 48/99 (48%), Gaps = 7/99 (7%)
Query: 733 EPPQVIEP--LKSMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPVKA-LPTKSDGDTHS 788
E P++ P L+ +RQ GE+V L G P+P TW N + + + GD S
Sbjct: 170 EAPKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGDQDS 229
Query: 789 ITILKPKKVKDEGVY--TLKAENSEGIAETSAVITVEEP 825
I ++ + D G Y T++ E+ E A ++ +E+P
Sbjct: 230 ILFIRSAQRSDSGRYELTVRVEDLEAKAVID-ILVIEKP 267
Score = 39.1 bits (87), Expect = 0.17
Identities = 30/96 (31%), Positives = 45/96 (46%), Gaps = 6/96 (6%)
Query: 634 PTFSKKPKAQYVDE-GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
P+F++ P A + G L C + A P+P I W+ EI + E + C
Sbjct: 382 PSFTQ-PLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKMEIQGNPKYRALSEQGV---C 437
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK 728
+ L+I F G YT A+N GEAS+ L++K
Sbjct: 438 T-LEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVK 472
Score = 34.3 bits (75), Expect = 4.9
Identities = 19/90 (21%), Positives = 39/90 (43%), Gaps = 2/90 (2%)
Query: 1786 ITWFPSEKNGGSPIIDYKVEI--KQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
+ W P + G + ++ Y V+ K+ G+ + I L I +Y FR+++ N
Sbjct: 285 LQWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSEN 344
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFV 1873
G S T ++ + ++P+ F+
Sbjct: 345 LCGLSTSATVTKELAHIQKADIAAKPKGFI 374
>DQ533874-1|ABF83431.1| 1378|Homo sapiens ROBO2 isoform b protein.
Length = 1378
Score = 93.9 bits (223), Expect = 6e-18
Identities = 82/312 (26%), Positives = 130/312 (41%), Gaps = 25/312 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
PTF ++P Q V E + C++ P+P + W K + +P I+ D
Sbjct: 225 PTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK-KDDADLPRGRYD--IKDDY----- 276
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
L+I EGTY +A NR G+ L ++ PPQ + + IV QG +V
Sbjct: 277 TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA----PPQFVVRPRDQIVAQGRTVT 332
Query: 754 LSAQVVGNPRPTITWCKN--------NKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+ GNP+P + W K N+P + S T +TI ++ D G Y
Sbjct: 333 FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQR-SDAGYYIC 391
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+A G A + V + + PP+ + T+ GT L + T +P+P I+
Sbjct: 392 QALTVAGSILAKAQLEVTDVLTDRP-PPIILQGPANQTLAVDGTALLKCKATGDPLPVIS 450
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W + P E L I N+ D+G Y CVA++S+G++S A + +
Sbjct: 451 WLKEG-FTFPGRDPRATIQ-EQGTLQIKNLRIS-DTGTYTCVATSSSGETSWSAVLDVTE 507
Query: 926 EKVTFVKHLQKS 937
T K+ S
Sbjct: 508 SGATISKNYDLS 519
Score = 81.0 bits (191), Expect = 4e-14
Identities = 88/418 (21%), Positives = 161/418 (38%), Gaps = 29/418 (6%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS--IDSKS 1342
+FPP+IV++ + + +G TL + P P EW + + ++ K S + S
Sbjct: 28 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
Query: 1343 ASLTIKKV-----ENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNILEIDS 1394
SL ++ D G Y N G A + + V +L +++
Sbjct: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAY 1454
+ P TI + + + D E IS++ + I N + + + +
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG---GKLMISNTRKSDAGMYTCV 204
Query: 1455 AVNEVDISDASETTEYYKVIKETKIQSPT-VEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
N V D S+ E T + PT + +P+ + E E +E C G PQP V
Sbjct: 205 GTNMVGERD-SDPAEL------TVFERPTFLRRPINQVVLE-EEAVEFRCQVQGDPQPTV 256
Query: 1514 TWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
W +D L + ++ Y CIA N G++E S + ++ P
Sbjct: 257 RWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 316
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK---LENDKEY--NITTKEKTS 1628
+ D Q G +G P P V W K G++ N + + + T
Sbjct: 317 VVRPRD--QIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 374
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+ I ++RS + Y +A AG+ + L+V D + P+I++ + +++ ++
Sbjct: 375 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 432
Score = 79.0 bits (186), Expect = 2e-13
Identities = 82/334 (24%), Positives = 132/334 (39%), Gaps = 34/334 (10%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE----NISVAIE 685
E PP + P V +G L C+ P P I W GE + D+ + + +
Sbjct: 27 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE-----ASLPIVLKIKTGEKEPPQVIEP 740
S + ++ K EG+Y VA N GE ASL + L + P V
Sbjct: 87 SGSLFFLRIVHGRRSKP-DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV--- 142
Query: 741 LKSMIVRQGESVILSAQVV-GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
+V GE IL Q G+P PTI W K+ + + + I +K D
Sbjct: 143 ----VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRK-SD 197
Query: 800 EGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT N G ++ A +TV E P F+ R V E+ ++ +V
Sbjct: 198 AGMYTCVGTNMVGERDSDPAELTV-------FERPTFLRRPINQVVLEEEAVEFRCQVQG 250
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
+P P++ W +++ ++ +D ++ + D G Y C+A N GK
Sbjct: 251 DPQPTVRWKKDD-----ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEAS 305
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT 952
A +T+ V+ + +G+TV C+T
Sbjct: 306 ATLTVRAPPQFVVR--PRDQIVAQGRTVTFPCET 337
Score = 72.1 bits (169), Expect = 2e-11
Identities = 114/495 (23%), Positives = 195/495 (39%), Gaps = 46/495 (9%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT 790
E PP+++E +IV +GE L+ + G P PTI W K+ + V+ K D +H +
Sbjct: 27 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVET--DKDDPRSHRML 84
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENA--EPPLFINRFQ----EITV 844
+ V+ +++ EG A + E NA E L + F+ ++ V
Sbjct: 85 LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 144
Query: 845 KEKGTIKLVARVTR-NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
L + R +P P+I W ++ I E + +L+I+N + D+G
Sbjct: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRGGKLMISNT-RKSDAGM 200
Query: 904 YKCVASNSAG-KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYH 962
Y CV +N G + S A +T+ E+ TF++ EE + V CQ
Sbjct: 201 YTCVGTNMVGERDSDPAELTV-FERPTFLRRPINQVVLEE-EAVEFRCQVQGDPQPTVRW 258
Query: 963 NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPE 1018
K + R I++ D G CI +++ E S L V+ P+
Sbjct: 259 KKDDADLPRGRYDIKD--DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP-PQ 315
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSETADVV-WERDG--EIIKPKKNKYDFEK--RGHIRK 1073
F+ + +D V + E V W+++G ++ P + + +
Sbjct: 316 FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 375
Query: 1074 LYIRNTSVHDEGEYSC----ILRDESCTAEVTVVEL-----PPEIITRLQNQKVNKGNKA 1124
L I N D G Y C + A++ V ++ PP I+ NQ + A
Sbjct: 376 LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA 435
Query: 1125 TFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC---- 1178
+ + T GD L + W K+G F ++ L+I + + D G Y+C
Sbjct: 436 LLKCKAT-GDPLPVISWLKEG--FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATS 492
Query: 1179 EVGNSKCTAILTVEE 1193
G + +A+L V E
Sbjct: 493 SSGETSWSAVLDVTE 507
Score = 66.9 bits (156), Expect = 7e-10
Identities = 45/195 (23%), Positives = 80/195 (41%), Gaps = 3/195 (1%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY- 691
PP F +P+ Q V +G + C P+P + W +G + + N S +
Sbjct: 313 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 372
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQG 749
L ITN+++ G Y A+ G L++ ++ PP +++ + +
Sbjct: 373 TGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 432
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ +L + G+P P I+W K ++ +K ++ D G YT A +
Sbjct: 433 GTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATS 492
Query: 810 SEGIAETSAVITVEE 824
S G SAV+ V E
Sbjct: 493 SSGETSWSAVLDVTE 507
Score = 60.5 bits (140), Expect = 6e-08
Identities = 103/477 (21%), Positives = 181/477 (37%), Gaps = 57/477 (11%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVE-M 1373
P+P W K+ K + SI + L I +DAG+Y N G D +
Sbjct: 161 PEPTIYW-KKDKVRIDDKEERISI--RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPA 217
Query: 1374 NVTILDKPSPPGKP-NILEIDSSSINI-CWDEPENTGNSTIIYYVVEYQEIDTTEWISVK 1431
+T+ ++P+ +P N + ++ ++ C + + T+ + + D + +
Sbjct: 218 ELTVFERPTFLRRPINQVVLEEEAVEFRC--QVQGDPQPTVRW------KKDDADLPRGR 269
Query: 1432 NITKTQTSIQNLKTNSSYR--FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
K +++ KT S+ + A N V +AS T + V +P
Sbjct: 270 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT-------VRAPPQFVVRPRD 322
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKK---------LKTAKATYENRXXXXXXXX 1540
I + + C G PQP V W ++G + ++ +
Sbjct: 323 QIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 381
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQ----KPVITISNEDIKQKHKVGDEWLVTAVI 1596
Y C A G + + + +P I Q V L+
Sbjct: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 441
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
G P P + W K G ++ T +E+ ++IK L+ S + YT A++++G +S
Sbjct: 442 TGDPLPVISWLKEGFTFPG-RDPRATIQEQ-GTLQIKNLRISDTGTYTCVATSSSGETSW 499
Query: 1657 EVTLKVY-------------DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAI 1703
L V D P P P + ++++ SVT+ W+P G L + Y I
Sbjct: 500 SAVLDVTESGATISKNYDLSDLPGPPSKPQVT-DVTKNSVTLSWQPGTP-GTLPASAYII 557
Query: 1704 EKHEPD-NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPI 1758
E +N W VA+ + Y ++ L N Y+F V A NP G S+ + S+P+
Sbjct: 558 EAFSQSVSNSWQTVANHVKTT-LYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPV 613
Score = 58.4 bits (135), Expect = 3e-07
Identities = 58/222 (26%), Positives = 88/222 (39%), Gaps = 34/222 (15%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA--IIKPSQDFQ--MYYDDDNV 565
P FV + R + G TV F C+ +G P+P + W ++ + ++ P+Q Q
Sbjct: 314 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXX 625
L I + DAG + C A AG + +L V L+D
Sbjct: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP----------------- 416
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
PP + P Q + LL+C+ P P I+WL +G P + I+
Sbjct: 417 -------PPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF-PGRDPRATIQ 468
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L+I N++ GTYT VA + GE S VL +
Sbjct: 469 EQ-----GTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
Score = 55.2 bits (127), Expect = 2e-06
Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 14/110 (12%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
+L VFE+PT + + + +E+ V+F CQV+G P+P + W + A +
Sbjct: 218 ELTVFERPTFLRRPINQVVLEE---------EAVEFRCQVQGDPQPTVRWKKDDADLPRG 268
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ YD + TL I++ D GT+ C+A+N G ++ L V AP
Sbjct: 269 R-----YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 313
Score = 54.0 bits (124), Expect = 6e-06
Identities = 96/418 (22%), Positives = 162/418 (38%), Gaps = 43/418 (10%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKR----GHI 1071
P + D V + + L + T + W +DGE ++ K+ + G +
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
Query: 1072 RKLYIRN--TSVHDEGEYSCILRDE-----SCTAEVTVVELPPEIITRLQNQKVNKGNKA 1124
L I + S DEG Y C+ R+ S A + V L + + V G A
Sbjct: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 150
Query: 1125 TFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
E + +G + + W KD I +++I G K L I + DAG Y+C N
Sbjct: 151 ILECQPPRGHPEPTIYWKKDKVRIDDKEE-RISIRGGK--LMISNTRKSDAGMYTCVGTN 207
Query: 1183 -----SKCTAILTV-EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVI 1236
A LTV E P+ LR P +V ++ + +KK
Sbjct: 208 MVGERDSDPAELTVFERPTF---LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 264
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER 1295
++ + D TL I+K D+ Y C+ + + + V PP+ V R
Sbjct: 265 LPRGRYDIKDDY---TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPR 321
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIV--NSKIIKKCKHTKPSID---SKSASLTIKKV 1350
+ + +G VT + + PQP W + ++ + +P+ S + LTI +
Sbjct: 322 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 381
Query: 1351 ENTDAGIYKLRLENNCG----HADVEMNVTILDKPSP---PGKPN-ILEIDSSSINIC 1400
+ +DAG Y + G A +E+ + D+P P G N L +D +++ C
Sbjct: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 439
Score = 41.1 bits (92), Expect = 0.042
Identities = 38/118 (32%), Positives = 56/118 (47%), Gaps = 15/118 (12%)
Query: 1865 PPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSVH 1923
PPS+P+ V++ T SVTL W +P + G P + YIIE F SW TV V
Sbjct: 524 PPSKPQ---VTDVTKNSVTLSW-QPGTPGTLPASAYIIEAFSQSVSNSWQ---TVANHVK 576
Query: 1924 E--HCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMV 1978
+ + ++ +F + A N G+S P+ S VR + SPP ++ R V
Sbjct: 577 TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQD----ISPPAQGVDHRQV 630
Score = 35.9 bits (79), Expect = 1.6
Identities = 29/109 (26%), Positives = 44/109 (40%), Gaps = 8/109 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQD----FQMYY 560
++ P VE G C+ EG P P I W++ ++ +D +M
Sbjct: 26 QEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL 85
Query: 561 DDDNVATLVI---REVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
++ L I R P D G++ CVA+N G A S + A L D
Sbjct: 86 PSGSLFFLRIVHGRRSKP-DEGSYVCVARNYLGEAVSRNASLEVALLRD 133
>DQ533873-1|ABF83430.1| 1394|Homo sapiens ROBO2 isoform a protein.
Length = 1394
Score = 93.9 bits (223), Expect = 6e-18
Identities = 82/312 (26%), Positives = 130/312 (41%), Gaps = 25/312 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
PTF ++P Q V E + C++ P+P + W K + +P I+ D
Sbjct: 241 PTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK-KDDADLPRGRYD--IKDDY----- 292
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
L+I EGTY +A NR G+ L ++ PPQ + + IV QG +V
Sbjct: 293 TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA----PPQFVVRPRDQIVAQGRTVT 348
Query: 754 LSAQVVGNPRPTITWCKN--------NKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+ GNP+P + W K N+P + S T +TI ++ D G Y
Sbjct: 349 FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQR-SDAGYYIC 407
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+A G A + V + + PP+ + T+ GT L + T +P+P I+
Sbjct: 408 QALTVAGSILAKAQLEVTDVLTDRP-PPIILQGPANQTLAVDGTALLKCKATGDPLPVIS 466
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W + P E L I N+ D+G Y CVA++S+G++S A + +
Sbjct: 467 WLKEG-FTFPGRDPRATIQ-EQGTLQIKNLRIS-DTGTYTCVATSSSGETSWSAVLDVTE 523
Query: 926 EKVTFVKHLQKS 937
T K+ S
Sbjct: 524 SGATISKNYDLS 535
Score = 81.0 bits (191), Expect = 4e-14
Identities = 88/418 (21%), Positives = 161/418 (38%), Gaps = 29/418 (6%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS--IDSKS 1342
+FPP+IV++ + + +G TL + P P EW + + ++ K S + S
Sbjct: 44 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 103
Query: 1343 ASLTIKKV-----ENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNILEIDS 1394
SL ++ D G Y N G A + + V +L +++
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 163
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAY 1454
+ P TI + + + D E IS++ + I N + + + +
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG---GKLMISNTRKSDAGMYTCV 220
Query: 1455 AVNEVDISDASETTEYYKVIKETKIQSPT-VEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
N V D S+ E T + PT + +P+ + E E +E C G PQP V
Sbjct: 221 GTNMVGERD-SDPAEL------TVFERPTFLRRPINQVVLE-EEAVEFRCQVQGDPQPTV 272
Query: 1514 TWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
W +D L + ++ Y CIA N G++E S + ++ P
Sbjct: 273 RWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 332
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK---LENDKEY--NITTKEKTS 1628
+ D Q G +G P P V W K G++ N + + + T
Sbjct: 333 VVRPRD--QIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 390
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+ I ++RS + Y +A AG+ + L+V D + P+I++ + +++ ++
Sbjct: 391 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 448
Score = 79.0 bits (186), Expect = 2e-13
Identities = 82/334 (24%), Positives = 132/334 (39%), Gaps = 34/334 (10%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE----NISVAIE 685
E PP + P V +G L C+ P P I W GE + D+ + + +
Sbjct: 43 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 102
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE-----ASLPIVLKIKTGEKEPPQVIEP 740
S + ++ K EG+Y VA N GE ASL + L + P V
Sbjct: 103 SGSLFFLRIVHGRRSKP-DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV--- 158
Query: 741 LKSMIVRQGESVILSAQVV-GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
+V GE IL Q G+P PTI W K+ + + + I +K D
Sbjct: 159 ----VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRK-SD 213
Query: 800 EGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT N G ++ A +TV E P F+ R V E+ ++ +V
Sbjct: 214 AGMYTCVGTNMVGERDSDPAELTV-------FERPTFLRRPINQVVLEEEAVEFRCQVQG 266
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
+P P++ W +++ ++ +D ++ + D G Y C+A N GK
Sbjct: 267 DPQPTVRWKKDD-----ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEAS 321
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT 952
A +T+ V+ + +G+TV C+T
Sbjct: 322 ATLTVRAPPQFVVR--PRDQIVAQGRTVTFPCET 353
Score = 72.1 bits (169), Expect = 2e-11
Identities = 114/495 (23%), Positives = 195/495 (39%), Gaps = 46/495 (9%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT 790
E PP+++E +IV +GE L+ + G P PTI W K+ + V+ K D +H +
Sbjct: 43 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVET--DKDDPRSHRML 100
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENA--EPPLFINRFQ----EITV 844
+ V+ +++ EG A + E NA E L + F+ ++ V
Sbjct: 101 LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 160
Query: 845 KEKGTIKLVARVTR-NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
L + R +P P+I W ++ I E + +L+I+N + D+G
Sbjct: 161 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRGGKLMISNT-RKSDAGM 216
Query: 904 YKCVASNSAG-KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYH 962
Y CV +N G + S A +T+ E+ TF++ EE + V CQ
Sbjct: 217 YTCVGTNMVGERDSDPAELTV-FERPTFLRRPINQVVLEE-EAVEFRCQVQGDPQPTVRW 274
Query: 963 NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPE 1018
K + R I++ D G CI +++ E S L V+ P+
Sbjct: 275 KKDDADLPRGRYDIKD--DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP-PQ 331
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSETADVV-WERDG--EIIKPKKNKYDFEK--RGHIRK 1073
F+ + +D V + E V W+++G ++ P + + +
Sbjct: 332 FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 391
Query: 1074 LYIRNTSVHDEGEYSC----ILRDESCTAEVTVVEL-----PPEIITRLQNQKVNKGNKA 1124
L I N D G Y C + A++ V ++ PP I+ NQ + A
Sbjct: 392 LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA 451
Query: 1125 TFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC---- 1178
+ + T GD L + W K+G F ++ L+I + + D G Y+C
Sbjct: 452 LLKCKAT-GDPLPVISWLKEG--FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATS 508
Query: 1179 EVGNSKCTAILTVEE 1193
G + +A+L V E
Sbjct: 509 SSGETSWSAVLDVTE 523
Score = 66.9 bits (156), Expect = 7e-10
Identities = 45/195 (23%), Positives = 80/195 (41%), Gaps = 3/195 (1%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY- 691
PP F +P+ Q V +G + C P+P + W +G + + N S +
Sbjct: 329 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 388
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQG 749
L ITN+++ G Y A+ G L++ ++ PP +++ + +
Sbjct: 389 TGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 448
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ +L + G+P P I+W K ++ +K ++ D G YT A +
Sbjct: 449 GTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATS 508
Query: 810 SEGIAETSAVITVEE 824
S G SAV+ V E
Sbjct: 509 SSGETSWSAVLDVTE 523
Score = 60.5 bits (140), Expect = 6e-08
Identities = 103/477 (21%), Positives = 181/477 (37%), Gaps = 57/477 (11%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVE-M 1373
P+P W K+ K + SI + L I +DAG+Y N G D +
Sbjct: 177 PEPTIYW-KKDKVRIDDKEERISI--RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPA 233
Query: 1374 NVTILDKPSPPGKP-NILEIDSSSINI-CWDEPENTGNSTIIYYVVEYQEIDTTEWISVK 1431
+T+ ++P+ +P N + ++ ++ C + + T+ + + D + +
Sbjct: 234 ELTVFERPTFLRRPINQVVLEEEAVEFRC--QVQGDPQPTVRW------KKDDADLPRGR 285
Query: 1432 NITKTQTSIQNLKTNSSYR--FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
K +++ KT S+ + A N V +AS T + V +P
Sbjct: 286 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT-------VRAPPQFVVRPRD 338
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKK---------LKTAKATYENRXXXXXXXX 1540
I + + C G PQP V W ++G + ++ +
Sbjct: 339 QIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 397
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQ----KPVITISNEDIKQKHKVGDEWLVTAVI 1596
Y C A G + + + +P I Q V L+
Sbjct: 398 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 457
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
G P P + W K G ++ T +E+ ++IK L+ S + YT A++++G +S
Sbjct: 458 TGDPLPVISWLKEGFTFPG-RDPRATIQEQ-GTLQIKNLRISDTGTYTCVATSSSGETSW 515
Query: 1657 EVTLKVY-------------DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAI 1703
L V D P P P + ++++ SVT+ W+P G L + Y I
Sbjct: 516 SAVLDVTESGATISKNYDLSDLPGPPSKPQVT-DVTKNSVTLSWQPGTP-GTLPASAYII 573
Query: 1704 EKHEPD-NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPI 1758
E +N W VA+ + Y ++ L N Y+F V A NP G S+ + S+P+
Sbjct: 574 EAFSQSVSNSWQTVANHVKTT-LYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPV 629
Score = 58.4 bits (135), Expect = 3e-07
Identities = 58/222 (26%), Positives = 88/222 (39%), Gaps = 34/222 (15%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA--IIKPSQDFQ--MYYDDDNV 565
P FV + R + G TV F C+ +G P+P + W ++ + ++ P+Q Q
Sbjct: 330 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 389
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXX 625
L I + DAG + C A AG + +L V L+D
Sbjct: 390 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP----------------- 432
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
PP + P Q + LL+C+ P P I+WL +G P + I+
Sbjct: 433 -------PPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF-PGRDPRATIQ 484
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L+I N++ GTYT VA + GE S VL +
Sbjct: 485 EQ-----GTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 521
Score = 55.2 bits (127), Expect = 2e-06
Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 14/110 (12%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
+L VFE+PT + + + +E+ V+F CQV+G P+P + W + A +
Sbjct: 234 ELTVFERPTFLRRPINQVVLEE---------EAVEFRCQVQGDPQPTVRWKKDDADLPRG 284
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ YD + TL I++ D GT+ C+A+N G ++ L V AP
Sbjct: 285 R-----YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 329
Score = 54.0 bits (124), Expect = 6e-06
Identities = 96/418 (22%), Positives = 162/418 (38%), Gaps = 43/418 (10%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKR----GHI 1071
P + D V + + L + T + W +DGE ++ K+ + G +
Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106
Query: 1072 RKLYIRN--TSVHDEGEYSCILRDE-----SCTAEVTVVELPPEIITRLQNQKVNKGNKA 1124
L I + S DEG Y C+ R+ S A + V L + + V G A
Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 166
Query: 1125 TFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
E + +G + + W KD I +++I G K L I + DAG Y+C N
Sbjct: 167 ILECQPPRGHPEPTIYWKKDKVRIDDKEE-RISIRGGK--LMISNTRKSDAGMYTCVGTN 223
Query: 1183 -----SKCTAILTV-EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVI 1236
A LTV E P+ LR P +V ++ + +KK
Sbjct: 224 MVGERDSDPAELTVFERPTF---LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 280
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER 1295
++ + D TL I+K D+ Y C+ + + + V PP+ V R
Sbjct: 281 LPRGRYDIKDDY---TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPR 337
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIV--NSKIIKKCKHTKPSID---SKSASLTIKKV 1350
+ + +G VT + + PQP W + ++ + +P+ S + LTI +
Sbjct: 338 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 397
Query: 1351 ENTDAGIYKLRLENNCG----HADVEMNVTILDKPSP---PGKPN-ILEIDSSSINIC 1400
+ +DAG Y + G A +E+ + D+P P G N L +D +++ C
Sbjct: 398 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 455
Score = 41.1 bits (92), Expect = 0.042
Identities = 38/118 (32%), Positives = 56/118 (47%), Gaps = 15/118 (12%)
Query: 1865 PPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSVH 1923
PPS+P+ V++ T SVTL W +P + G P + YIIE F SW TV V
Sbjct: 540 PPSKPQ---VTDVTKNSVTLSW-QPGTPGTLPASAYIIEAFSQSVSNSWQ---TVANHVK 592
Query: 1924 E--HCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMV 1978
+ + ++ +F + A N G+S P+ S VR + SPP ++ R V
Sbjct: 593 TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQD----ISPPAQGVDHRQV 646
Score = 35.9 bits (79), Expect = 1.6
Identities = 29/109 (26%), Positives = 44/109 (40%), Gaps = 8/109 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQD----FQMYY 560
++ P VE G C+ EG P P I W++ ++ +D +M
Sbjct: 42 QEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL 101
Query: 561 DDDNVATLVI---REVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
++ L I R P D G++ CVA+N G A S + A L D
Sbjct: 102 PSGSLFFLRIVHGRRSKP-DEGSYVCVARNYLGEAVSRNASLEVALLRD 149
>BX538010-1|CAD97960.1| 1183|Homo sapiens hypothetical protein
protein.
Length = 1183
Score = 93.9 bits (223), Expect = 6e-18
Identities = 114/478 (23%), Positives = 194/478 (40%), Gaps = 48/478 (10%)
Query: 507 SMAPIFV-EKLRPKHTPDGSTVQFECQVE-GYPRPQITWFRQTAIIKP-SQDFQMYYDDD 563
S +P++ EKL P G ++ C+ G P P I W + P S+ + D
Sbjct: 136 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGD 195
Query: 564 NVATLVIREVFPEDAGT-FTCVAK-NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
L V PED + C A+ N + V+ D ++ T+
Sbjct: 196 ----LYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELND-TIAANLSDTE 250
Query: 622 XXXXADILEGIPPTF-SKKPKAQYVDE--GSDILLECRLVAIPEPDIAWLFKGEEIVPDE 678
E PPTF + + A +E G+ + LEC +P P I W K + ++P +
Sbjct: 251 FYGAKSSRER-PPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWA-KEDGMLP-K 307
Query: 679 NISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
N +V + L+I +V + G Y +A N G I +++K P I
Sbjct: 308 NRTVYKNFE-----KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA----PYWI 358
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP----TKSDGDTHSITILKP 794
+++++ GE L + GNP+P I+W N P++ P K DGDT I
Sbjct: 359 TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDT---IIFSN 415
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-TVKEKGTIKLV 853
+ + VY A N G +A + V AEPP + + V L
Sbjct: 416 VQERSSAVYQCNASNEYGYLLANAFVNV------LAEPPRILTPANTLYQVIANRPALLD 469
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+P+P+I W++ + + E I + +E+ + DS +G Y CVA N G
Sbjct: 470 CAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDS---TGTYTCVARNKLG 526
Query: 914 KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH----TVSTKWYHNKKEI 967
+ + V ++++ T++ + + G V EC+ H +++ W + +E+
Sbjct: 527 MAKN--EVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL 582
Score = 90.2 bits (214), Expect = 7e-17
Identities = 166/763 (21%), Positives = 295/763 (38%), Gaps = 74/763 (9%)
Query: 1044 TADVVWERDGEIIKPKKNKY-DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
T + W ++ ++ + Y +FEK L I + S D G Y CI ++ T+
Sbjct: 293 TPIIYWAKEDGMLPKNRTVYKNFEKT-----LQIIHVSEADSGNYQCIAKNALGAIHHTI 347
Query: 1103 ---VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFS-NHIQLTI 1156
V+ P IT QN ++ G T I G+ R W +G I+ + + I
Sbjct: 348 SVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVPIEIAPDDPSRKI 406
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
DG + + + Y C N + +N L P IL PANT Y
Sbjct: 407 DG--DTIIFSNVQERSSAVYQCNASNEYGYLLANA---FVN-VLAEPPRILTPANT-LYQ 459
Query: 1217 TVEIPDETLDVTWYKKK-SVIE---DTEKFTLISDV----KKRTLIIRKCTEDDQCEYTC 1268
+ LD ++ IE + L D+ + TL I +D YTC
Sbjct: 460 VIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTC 519
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
V + K +V + P + + EY + +RGS +V ++ + +D + + +
Sbjct: 520 VARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGS----MVSFECKVK-HDHTLSLTVL 574
Query: 1328 IKKCKHTKPSIDSKSAS---LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP 1384
K PS + + L + V + D+G Y ++++D P+PP
Sbjct: 575 WLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPP 634
Query: 1385 GKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEI--DTTEWISVKNITKTQTSIQ- 1441
+ + S+ + W P + NS I +++EY++ W ++ TQT+ Q
Sbjct: 635 FDLELTDQLDKSVQLSW-TPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQL 693
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN------ITTEP 1495
L +Y FR AVN + S SE +E Y ++PT + L + IT +P
Sbjct: 694 KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKP 753
Query: 1496 NEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFND 1555
E G Q KV+W + + N K A ND
Sbjct: 754 LNGFESN---GPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALND 810
Query: 1556 HG-EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE 1614
G E + V+G + + ++ +++ V + L + +P + + G ++
Sbjct: 811 MGFAPEPAVVMGHSGEDLPMVAPGNVRV--NVVNSTLAEVHWDPVPLKSIRGHLQGYRIY 868
Query: 1615 NDKEYNITTKEKTSV---IRIKELKRSHS--------SKYTIEASNTAGTSSVEVTL-KV 1662
K + + + + + I + ++H S YT+ G + +V
Sbjct: 869 YWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPLSHYTLNVRVVNGKGEGPASPDRV 928
Query: 1663 YDKP-SKPEGPVIMREI--SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADV 1719
++ P P P ++ + + +S+T+EW PP G+ LT+Y + K++P N+ V
Sbjct: 929 FNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGI-LTEYTL-KYQPINSTHELGPLV 986
Query: 1720 DRDVET----YCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
D + T + ++ LN + Y F AQ G + E +
Sbjct: 987 DLKIPTNKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAV 1029
Score = 90.2 bits (214), Expect = 7e-17
Identities = 114/524 (21%), Positives = 211/524 (40%), Gaps = 53/524 (10%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXX 1545
+N+ P ED L C G P+P+++W +G ++ A +
Sbjct: 362 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSS 421
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C A N++G + + V + +P ++ + + L+ G P P +
Sbjct: 422 AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIE 481
Query: 1606 WYK--NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
W+K G+ L D I + + I ++ + YT A N G + EV L++
Sbjct: 482 WFKGAKGSALHED----IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK 537
Query: 1664 DKP---SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE--PDNNRWIKVAD 1718
D +PE V+ R V+ E K D L LT ++ + P + R+
Sbjct: 538 DPTWIVKQPEYAVVQR---GSMVSFECKVK-HDHTLSLTVLWLKDNRELPSDERF----T 589
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXX 1778
VD+D + ++++ + +A + +++ + ++ + +DVP+
Sbjct: 590 VDKD--HLVVADVSDDDSGTYTCVANTTL---DSVSASAVL--SVVDVPNPPFDLELTDQ 642
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXARIQ-KLSINTT 1834
+D +SV ++W P + N SPI + +E + K W Q KLS
Sbjct: 643 LD-KSVQLSWTPGDDN-NSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVN 700
Query: 1835 YQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP----E 1890
Y FR+ A N IG SLP + ++ + K P P S ++ + W +P E
Sbjct: 701 YSFRVMAVNSIGKSLPSEASEQY-LTKASEPDKNPTAVEGLGSEPDNLVITW-KPLNGFE 758
Query: 1891 SNGGSPITNYIIEFKTVKG-KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVS 1949
SNG P Y + ++ G WT +V +V ++ + + ++ A N +G +
Sbjct: 759 SNG--PGLQYKVSWRQKDGDDEWTSVVV--ANVSKYIVSGTPTFVPYLIKVQALNDMGFA 814
Query: 1950 LPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+ + H+ P AP +R+ N+V ++ WD
Sbjct: 815 ----PEPAVVMGHSGEDLPMVAPGNVRV---NVVNSTLAEVHWD 851
Score = 84.6 bits (200), Expect = 3e-15
Identities = 132/623 (21%), Positives = 249/623 (39%), Gaps = 71/623 (11%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 39 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 98
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 99 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 155
Query: 751 SVILSAQ-VVGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 156 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 212
Query: 804 TLKAENSEGIAE----TSAVITVEE----------PTE------ENAEPPLFINRFQEIT 843
+ +++ I + + VI+V+E TE PP F+ +
Sbjct: 213 YARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNAS 272
Query: 844 VKE--KGTIKLVARVTRN-PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEID 900
KE +G + + + P P I W + + ++ + T+ +NF+ + ++++ SE D
Sbjct: 273 NKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-KTLQIIHV---SEAD 328
Query: 901 SGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKW 960
SG+Y+C+A N+ G H V + E T+I + W
Sbjct: 329 SGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISW 388
Query: 961 YHN--KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKE 1014
N EI+ D I +G V +C ++ + + V
Sbjct: 389 LTNGVPIEIAPDDPSRKI-DGDTIIFSNVQERSS--AVYQCNASNEYGYLLANAFVNVLA 445
Query: 1015 TIPEFIRKLQD-FEVKEKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
P + ++V A+L+ S + W + + ++ Y + G
Sbjct: 446 EPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG--- 502
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIE 1129
L I G Y+C+ R++ A+ V ++ P I+ + + V +G+ +FE +
Sbjct: 503 TLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECK 562
Query: 1130 LTKGDAL---VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS--- 1183
+ L V W KD E+ + T+D K L + D DD+G Y+C +
Sbjct: 563 VKHDHTLSLTVLWLKDNRELPSDE--RFTVD--KDHLVVADVSDDDSGTYTCVANTTLDS 618
Query: 1184 -KCTAILT-VEEPSINFTLRLPE 1204
+A+L+ V+ P+ F L L +
Sbjct: 619 VSASAVLSVVDVPNPPFDLELTD 641
Score = 65.3 bits (152), Expect = 2e-09
Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 8/191 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P+ P + +++ +SV L WT P + SPIT +IIE++ K W V G+
Sbjct: 631 PNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 689
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++ + FR+ A N++G SLP+E+ L K + PTA + N+V
Sbjct: 690 TAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLV 748
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+T ++ P L Y ++ R W V V N K+ + Y+I++
Sbjct: 749 ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSV--VVANVSKYIVSGTPTFVPYLIKVQ 806
Query: 2043 ARNEIGLS-EP 2052
A N++G + EP
Sbjct: 807 ALNDMGFAPEP 817
Score = 57.6 bits (133), Expect = 5e-07
Identities = 63/290 (21%), Positives = 114/290 (39%), Gaps = 12/290 (4%)
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
PP P I +D+S + E + G + +Y+ E ++I TQT IQ
Sbjct: 168 PP--PIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQT-IQQ 224
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN---EDI 1499
+ S +N+ ++ S+T E+Y K ++ + PT P N + + +
Sbjct: 225 KQPISVKVISVDELNDTIAANLSDT-EFYGA-KSSRERPPTFLTPEGNASNKEELRGNVL 282
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L CI G+P P + W ++ L + Y+N Y+CIA N G
Sbjct: 283 SLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGA 342
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + V ++ P + +++ G++ + G P P + W NG +E +
Sbjct: 343 IHHTISVRVKAAPYWITAPQNLVL--SPGEDGTLICRANGNPKPRISWLTNGVPIEIAPD 400
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + K I ++ S+ Y ASN G + V +P +
Sbjct: 401 -DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPR 449
Score = 40.7 bits (91), Expect = 0.056
Identities = 28/92 (30%), Positives = 46/92 (50%), Gaps = 8/92 (8%)
Query: 524 GSTVQFECQVEGYPRPQIT--WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V FEC+V+ +T W + + + F + D D+ LV+ +V +D+GT+
Sbjct: 554 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV--DKDH---LVVADVSDDDSGTY 608
Query: 582 TCVAKNAAGFASSTTEL-IVEAPLSDHGSEMT 612
TCVA S++ L +V+ P E+T
Sbjct: 609 TCVANTTLDSVSASAVLSVVDVPNPPFDLELT 640
>AJ001057-1|CAA04507.1| 1299|Homo sapiens NrCAM protein protein.
Length = 1299
Score = 93.9 bits (223), Expect = 6e-18
Identities = 114/478 (23%), Positives = 194/478 (40%), Gaps = 48/478 (10%)
Query: 507 SMAPIFV-EKLRPKHTPDGSTVQFECQVE-GYPRPQITWFRQTAIIKP-SQDFQMYYDDD 563
S +P++ EKL P G ++ C+ G P P I W + P S+ + D
Sbjct: 137 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGD 196
Query: 564 NVATLVIREVFPEDAGT-FTCVAK-NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
L V PED + C A+ N + V+ D ++ T+
Sbjct: 197 ----LYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELND-TIAANLSDTE 251
Query: 622 XXXXADILEGIPPTF-SKKPKAQYVDE--GSDILLECRLVAIPEPDIAWLFKGEEIVPDE 678
E PPTF + + A +E G+ + LEC +P P I W K + ++P +
Sbjct: 252 FYGAKSSRER-PPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWA-KEDGMLP-K 308
Query: 679 NISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
N +V + L+I +V + G Y +A N G I +++K P I
Sbjct: 309 NRTVYKNFE-----KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA----PYWI 359
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP----TKSDGDTHSITILKP 794
+++++ GE L + GNP+P I+W N P++ P K DGDT I
Sbjct: 360 TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDT---IIFSN 416
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-TVKEKGTIKLV 853
+ + VY A N G +A + V AEPP + + V L
Sbjct: 417 VQERSSAVYQCNASNEYGYLLANAFVNV------LAEPPRILTPANTLYQVIANRPALLD 470
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+P+P+I W++ + + E I + +E+ + DS +G Y CVA N G
Sbjct: 471 CAFFGSPLPTIQWFKGAKGSALHEDIYVLHENGTLEIPVAQKDS---TGTYTCVARNKLG 527
Query: 914 KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH----TVSTKWYHNKKEI 967
+ + V ++++ T++ + + G V EC+ H +++ W + +E+
Sbjct: 528 MAKN--EVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL 583
Score = 85.0 bits (201), Expect = 3e-15
Identities = 135/647 (20%), Positives = 259/647 (40%), Gaps = 74/647 (11%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 40 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 99
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 100 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 156
Query: 751 SVILSAQ-VVGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 157 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 213
Query: 804 TLKAENSEGIAE----TSAVITVEE----------PTE------ENAEPPLFINRFQEIT 843
+ +++ I + + VI+V+E TE PP F+ +
Sbjct: 214 YARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNAS 273
Query: 844 VKE--KGTIKLVARVTRN-PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEID 900
KE +G + + + P P I W + + ++ + T+ +NF+ + ++++ SE D
Sbjct: 274 NKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-KTLQIIHV---SEAD 329
Query: 901 SGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKW 960
SG+Y+C+A N+ G H V + E T+I + W
Sbjct: 330 SGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISW 389
Query: 961 YHN--KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKE 1014
N EI+ D I +G V +C ++ + + V
Sbjct: 390 LTNGVPIEIAPDDPSRKI-DGDTIIFSNVQERSS--AVYQCNASNEYGYLLANAFVNVLA 446
Query: 1015 TIPEFIRKLQD-FEVKEKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
P + ++V A+L+ S + W + + ++ Y + G
Sbjct: 447 EPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIQWFKGAKGSALHEDIYVLHENG--- 503
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIE 1129
L I G Y+C+ R++ A+ V ++ P I+ + + V +G+ +FE +
Sbjct: 504 TLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECK 563
Query: 1130 LTKGDAL---VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS--- 1183
+ L V W KD E+ + T+D K L + D DD+G Y+C +
Sbjct: 564 VKHDHTLSLTVLWLKDNRELPSDE--RFTVD--KDHLVVADVSDDDSGTYTCVANTTLDS 619
Query: 1184 -KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+A+L+V P+ P + + D LT ++ D+++ ++W
Sbjct: 620 VSASAVLSVVAPT---PTPAPVYDVPNPPLDLELTDQL-DKSVQLSW 662
Score = 83.4 bits (197), Expect = 8e-15
Identities = 116/529 (21%), Positives = 204/529 (38%), Gaps = 53/529 (10%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXX 1545
+N+ P ED L C G P+P+++W +G ++ A +
Sbjct: 363 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSS 422
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C A N++G + + V + +P ++ + + L+ G P P +
Sbjct: 423 AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIQ 482
Query: 1606 WYK--NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
W+K G+ L D I + + I ++ + YT A N G + EV L++
Sbjct: 483 WFKGAKGSALHED----IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK 538
Query: 1664 DKP---SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE--PDNNRWIKVAD 1718
D +PE V+ R V+ E K D L LT ++ + P + R+
Sbjct: 539 DPTWIVKQPEYAVVQR---GSMVSFECKVK-HDHTLSLTVLWLKDNRELPSDERF----T 590
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT-----ALDVPSXXXXX 1773
VD+D + ++++ + +A + A +V T DVP+
Sbjct: 591 VDKD--HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPLDL 648
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXARIQ-KL 1829
+D +SV ++W P + N SPI E + K W Q KL
Sbjct: 649 ELTDQLD-KSVQLSWTPGDDN-NSPITTIHDEYEDAMHKPGLWHHQTEVSGTQTTAQLKL 706
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP 1889
S Y FR+ A N IG SLP + ++ + K P P S ++ + W +P
Sbjct: 707 SPYVNYSFRVMAVNSIGKSLPSEASEQY-LTKASEPDKNPTAVEGLGSEPDNLVITW-KP 764
Query: 1890 ----ESNGGSPITNYIIEFKTVKG-KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
E NG P Y + ++ G WT +V +V ++ + + ++ A N
Sbjct: 765 LNGFEFNG--PGLQYKVSWRQKVGDDEWTSVVV--ANVSKYIVSGTPTFVPYLIKVQALN 820
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+G + + + H+ P AP +R+ N+V ++ WD
Sbjct: 821 DMGFA----PEPAVVMGHSGEDLPMVAPGNVRV---NVVNSTLAEVHWD 862
Score = 69.7 bits (163), Expect = 1e-10
Identities = 164/773 (21%), Positives = 289/773 (37%), Gaps = 84/773 (10%)
Query: 1044 TADVVWERDGEIIKPKKNKY-DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
T + W ++ ++ + Y +FEK L I + S D G Y CI ++ T+
Sbjct: 294 TPIIYWAKEDGMLPKNRTVYKNFEKT-----LQIIHVSEADSGNYQCIAKNALGAIHHTI 348
Query: 1103 ---VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFS-NHIQLTI 1156
V+ P IT QN ++ G T I G+ R W +G I+ + + I
Sbjct: 349 SVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVPIEIAPDDPSRKI 407
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
DG + + + Y C N + +N L P IL PANT Y
Sbjct: 408 DG--DTIIFSNVQERSSAVYQCNASNEYGYLLANA---FVN-VLAEPPRILTPANT-LYQ 460
Query: 1217 TVEIPDETLDVTWYKKK----SVIEDTEKFTLISDV----KKRTLIIRKCTEDDQCEYTC 1268
+ LD ++ + + L D+ + TL I +D YTC
Sbjct: 461 VIANRPALLDCAFFGSPLPTIQWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTC 520
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
V + K +V + P + + EY + +RGS +V ++ + +D + + +
Sbjct: 521 VARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGS----MVSFECKVK-HDHTLSLTVL 575
Query: 1328 IKKCKHTKPSIDSKSAS---LTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL------ 1378
K PS + + L + V + D+G Y ++++
Sbjct: 576 WLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTP 635
Query: 1379 ----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISVKN 1432
D P+PP + + S+ + W P + NS I EY++ W
Sbjct: 636 APVYDVPNPPLDLELTDQLDKSVQLSWT-PGDDNNSPITTIHDEYEDAMHKPGLWHHQTE 694
Query: 1433 ITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN- 1490
++ TQT+ Q L +Y FR AVN + S SE +E Y ++PT + L +
Sbjct: 695 VSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSE 754
Query: 1491 -----ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXX 1545
IT +P E G Q KV+W + + N
Sbjct: 755 PDNLVITWKPLNGFEFN---GPGLQYKVSWRQKVGDDEWTSVVVANVSKYIVSGTPTFVP 811
Query: 1546 XXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV 1604
K A ND G E + V+G + + ++ +++ V + L + +P +
Sbjct: 812 YLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRV--NVVNSTLAEVHWDPVPLKSI 869
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSV---IRIKELKRSHS--------SKYTIEASNTAGT 1653
+ G ++ K + + + + + I + ++H S YT+ G
Sbjct: 870 RGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGK 929
Query: 1654 SSVEVTL-KVYDKP-SKPEGPVIMREI--SRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
+ +V++ P P P ++ + + +S+T+EW PP G+ LT+Y + K++P
Sbjct: 930 GEGPASPDRVFNTPEGVPSVPSSLKIVNPTLDSLTLEWDPPSHPNGI-LTEYTL-KYQPI 987
Query: 1710 NNRWIKVADVDRDVET----YCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
NN VD + + ++ LN Y F AQ G + E +
Sbjct: 988 NNTHELGPLVDLKIPANKTRWTLKNLNFTTRYKFYFYAQTSAGSGSQITEEAV 1040
Score = 59.3 bits (137), Expect = 1e-07
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 8/191 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P+ P + +++ +SV L WT P + SPIT E++ K W V G+
Sbjct: 642 PNPPLDLELTDQLDKSVQLSWT-PGDDNNSPITTIHDEYEDAMHKPGLWHHQTEVSGTQT 700
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++ + FR+ A N++G SLP+E+ L K + PTA + N+V
Sbjct: 701 TAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLV 759
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRD-VTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+T ++ P L Y ++ R V W V V N K+ + Y+I++
Sbjct: 760 ITWKPLNGFEFNGPGLQYKVSWRQKVGDDEWTSV--VVANVSKYIVSGTPTFVPYLIKVQ 817
Query: 2043 ARNEIGLS-EP 2052
A N++G + EP
Sbjct: 818 ALNDMGFAPEP 828
Score = 57.6 bits (133), Expect = 5e-07
Identities = 63/290 (21%), Positives = 114/290 (39%), Gaps = 12/290 (4%)
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
PP P I +D+S + E + G + +Y+ E ++I TQT IQ
Sbjct: 169 PP--PIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQT-IQQ 225
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN---EDI 1499
+ S +N+ ++ S+T E+Y K ++ + PT P N + + +
Sbjct: 226 KQPISVKVISVDELNDTIAANLSDT-EFYGA-KSSRERPPTFLTPEGNASNKEELRGNVL 283
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L CI G+P P + W ++ L + Y+N Y+CIA N G
Sbjct: 284 SLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGA 343
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + V ++ P + +++ G++ + G P P + W NG +E +
Sbjct: 344 IHHTISVRVKAAPYWITAPQNLVL--SPGEDGTLICRANGNPKPRISWLTNGVPIEIAPD 401
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + K I ++ S+ Y ASN G + V +P +
Sbjct: 402 -DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPR 450
Score = 56.4 bits (130), Expect = 1e-06
Identities = 135/633 (21%), Positives = 238/633 (37%), Gaps = 78/633 (12%)
Query: 721 LPIVLKIKTGEKEPPQVIEPL-KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA-- 777
+P+ K+ +PP + + K I+ E++++ + G P P+ +W +N
Sbjct: 27 VPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDK 86
Query: 778 --LPTKSDGD-THSITILKPKKVKD-EGVYTLKAENSEGIAETSAVIT--VEEP--TEEN 829
L T G T I I+ K + EGVY A N G A ++ ++ P T+E
Sbjct: 87 DPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEK 146
Query: 830 AEP---------------------PLFI---NRFQEITVKEKGTIKLVARVT-RNPVPSI 864
EP P+ N FQ + E+ + L + N +P
Sbjct: 147 LEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPED 206
Query: 865 TWYRNNEIISPSETITQNFDGEN-IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
T R + I TQ + I + + +VD D+ +A+N + +GA+ +
Sbjct: 207 T--REDYICYARFNHTQTIQQKQPISVKVISVDELNDT-----IAANLSDTEFYGAKSSR 259
Query: 924 DVEKVTFVKHLQKSYETEE--GKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRX 981
+ TF+ + EE G + LEC + + T + KE + + +
Sbjct: 260 E-RPPTFLTPEGNASNKEELRGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTVYKNFE 317
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETS---TMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
D G +CI K+ + T+ V + P +I Q+ + + L
Sbjct: 318 KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLIC 377
Query: 1039 EINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES-- 1095
N + W +G I+ + D ++ + N Y C +E
Sbjct: 378 RANGNPKPRISWLTNGVPIEIAPD--DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGY 435
Query: 1096 --CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNH 1151
A V V+ PP I+T N+ G L ++WFK H
Sbjct: 436 LLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIQWFKGAKGSAL--H 493
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFIL 1207
+ + + L+I D G Y+C ++G +K L +++P+ + ++ PE+ +
Sbjct: 494 EDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPT--WIVKQPEYAV 551
Query: 1208 VPANTDAYLTVEIP-DETLDVT--WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQC 1264
V + ++ D TL +T W K + E+FT V K L++ ++DD
Sbjct: 552 VQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFT----VDKDHLVVADVSDDDSG 607
Query: 1265 EYTCV---LLDAKSTTKLKVEVVEFPPKIVDYE 1294
YTCV LD+ S + + V P Y+
Sbjct: 608 TYTCVANTTLDSVSASAVLSVVAPTPTPAPVYD 640
Score = 41.9 bits (94), Expect = 0.024
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 524 GSTVQFECQVEGYPRPQIT--WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V FEC+V+ +T W + + + F + D D+ LV+ +V +D+GT+
Sbjct: 555 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV--DKDH---LVVADVSDDDSGTY 609
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA S++ L V AP
Sbjct: 610 TCVANTTLDSVSASAVLSVVAP 631
Score = 39.9 bits (89), Expect = 0.098
Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 7/109 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE----WISVK-NITK 1435
PS P I+ S+ + WD P + N + Y ++YQ I+ T + +K K
Sbjct: 947 PSVPSSLKIVNPTLDSLTLEWDPPSHP-NGILTEYTLKYQPINNTHELGPLVDLKIPANK 1005
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
T+ +++NL + Y+F YA S + T E + E I P V
Sbjct: 1006 TRWTLKNLNFTTRYKFYFYAQTSAG-SGSQITEEAVTTVDEAGILPPDV 1053
Score = 37.1 bits (82), Expect = 0.69
Identities = 38/146 (26%), Positives = 58/146 (39%), Gaps = 14/146 (9%)
Query: 1476 ETKIQSPTV-EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG-------KKLKTAK- 1526
E +Q PT+ ++ K+ +P E+I + C G P P +W R+G L T K
Sbjct: 35 EDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP 94
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHK 1585
T Y+C A N+ G V + VV + P+ T E ++
Sbjct: 95 GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWT--KEKLEPITL 152
Query: 1586 VGDEWLVTAVIE--GIPPPEVIWYKN 1609
+ LV G+PPP + W N
Sbjct: 153 QSGQSLVLPCRPPIGLPPPIIFWMDN 178
>AF172277-2|AAF22283.1| 1236|Homo sapiens NgCAM-related related cell
adhesion molecule /alternative carboxyl terminus
protein.
Length = 1236
Score = 93.9 bits (223), Expect = 6e-18
Identities = 114/478 (23%), Positives = 194/478 (40%), Gaps = 48/478 (10%)
Query: 507 SMAPIFV-EKLRPKHTPDGSTVQFECQVE-GYPRPQITWFRQTAIIKP-SQDFQMYYDDD 563
S +P++ EKL P G ++ C+ G P P I W + P S+ + D
Sbjct: 142 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGD 201
Query: 564 NVATLVIREVFPEDAGT-FTCVAK-NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
L V PED + C A+ N + V+ D ++ T+
Sbjct: 202 ----LYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELND-TIAANLSDTE 256
Query: 622 XXXXADILEGIPPTF-SKKPKAQYVDE--GSDILLECRLVAIPEPDIAWLFKGEEIVPDE 678
E PPTF + + A +E G+ + LEC +P P I W K + ++P +
Sbjct: 257 FYGAKSSRER-PPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWA-KEDGMLP-K 313
Query: 679 NISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
N +V + L+I +V + G Y +A N G I +++K P I
Sbjct: 314 NRTVYKNFE-----KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA----PYWI 364
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP----TKSDGDTHSITILKP 794
+++++ GE L + GNP+P I+W N P++ P K DGDT I
Sbjct: 365 TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDT---IIFSN 421
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-TVKEKGTIKLV 853
+ + VY A N G +A + V AEPP + + V L
Sbjct: 422 VQERSSAVYQCNASNEYGYLLANAFVNV------LAEPPRILTPANTLYQVIANRPALLD 475
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+P+P+I W++ + + E I + +E+ + DS +G Y CVA N G
Sbjct: 476 CAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDS---TGTYTCVARNKLG 532
Query: 914 KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH----TVSTKWYHNKKEI 967
+ + V ++++ T++ + + G V EC+ H +++ W + +E+
Sbjct: 533 MAKN--EVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL 588
Score = 89.4 bits (212), Expect = 1e-16
Identities = 117/529 (22%), Positives = 207/529 (39%), Gaps = 53/529 (10%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXX 1545
+N+ P ED L C G P+P+++W +G ++ A +
Sbjct: 368 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSS 427
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C A N++G + + V + +P ++ + + L+ G P P +
Sbjct: 428 AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIE 487
Query: 1606 WYK--NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
W+K G+ L D I + + I ++ + YT A N G + EV L++
Sbjct: 488 WFKGAKGSALHED----IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK 543
Query: 1664 DKP---SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE--PDNNRWIKVAD 1718
D +PE V+ R V+ E K D L LT ++ + P + R+
Sbjct: 544 DPTWIVKQPEYAVVQR---GSMVSFECKVK-HDHTLSLTVLWLKDNRELPSDERF----T 595
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT-----ALDVPSXXXXX 1773
VD+D + ++++ + +A + A +V T DVP+
Sbjct: 596 VDKD--HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDL 653
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXARIQ-KL 1829
+D +SV ++W P + N SPI + +E + K W Q KL
Sbjct: 654 ELTDQLD-KSVQLSWTPGDDN-NSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKL 711
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP 1889
S Y FR+ A N IG SLP + ++ + K P P S ++ + W +P
Sbjct: 712 SPYVNYSFRVMAVNSIGKSLPSEASEQY-LTKASEPDKNPTAVEGLGSEPDNLVITW-KP 769
Query: 1890 ----ESNGGSPITNYIIEFKTVKG-KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
ESNG P Y + ++ G WT +V +V ++ + + ++ A N
Sbjct: 770 LNGFESNG--PGLQYKVSWRQKDGDDEWTSVVV--ANVSKYIVSGTPTFVPYLIKVQALN 825
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+G + + + H+ P AP +R+ N+V ++ WD
Sbjct: 826 DMGFA----PEPAVVMGHSGEDLPMVAPGNVRV---NVVNSTLAEVHWD 867
Score = 84.6 bits (200), Expect = 3e-15
Identities = 135/647 (20%), Positives = 259/647 (40%), Gaps = 74/647 (11%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 45 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 161
Query: 751 SVILSAQ-VVGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 162 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 218
Query: 804 TLKAENSEGIAE----TSAVITVEE----------PTE------ENAEPPLFINRFQEIT 843
+ +++ I + + VI+V+E TE PP F+ +
Sbjct: 219 YARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNAS 278
Query: 844 VKE--KGTIKLVARVTRN-PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEID 900
KE +G + + + P P I W + + ++ + T+ +NF+ + ++++ SE D
Sbjct: 279 NKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-KTLQIIHV---SEAD 334
Query: 901 SGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKW 960
SG+Y+C+A N+ G H V + E T+I + W
Sbjct: 335 SGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISW 394
Query: 961 YHN--KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKE 1014
N EI+ D I +G V +C ++ + + V
Sbjct: 395 LTNGVPIEIAPDDPSRKI-DGDTIIFSNVQERSS--AVYQCNASNEYGYLLANAFVNVLA 451
Query: 1015 TIPEFIRKLQD-FEVKEKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
P + ++V A+L+ S + W + + ++ Y + G
Sbjct: 452 EPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG--- 508
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIE 1129
L I G Y+C+ R++ A+ V ++ P I+ + + V +G+ +FE +
Sbjct: 509 TLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECK 568
Query: 1130 LTKGDAL---VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS--- 1183
+ L V W KD E+ + T+D K L + D DD+G Y+C +
Sbjct: 569 VKHDHTLSLTVLWLKDNRELPSDE--RFTVD--KDHLVVADVSDDDSGTYTCVANTTLDS 624
Query: 1184 -KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+A+L+V P+ P + + D LT ++ D+++ ++W
Sbjct: 625 VSASAVLSVVAPT---PTPAPVYDVPNPPFDLELTDQL-DKSVQLSW 667
Score = 76.6 bits (180), Expect = 9e-13
Identities = 165/773 (21%), Positives = 294/773 (38%), Gaps = 84/773 (10%)
Query: 1044 TADVVWERDGEIIKPKKNKY-DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
T + W ++ ++ + Y +FEK L I + S D G Y CI ++ T+
Sbjct: 299 TPIIYWAKEDGMLPKNRTVYKNFEKT-----LQIIHVSEADSGNYQCIAKNALGAIHHTI 353
Query: 1103 ---VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFS-NHIQLTI 1156
V+ P IT QN ++ G T I G+ R W +G I+ + + I
Sbjct: 354 SVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVPIEIAPDDPSRKI 412
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
DG + + + Y C N + +N L P IL PANT Y
Sbjct: 413 DG--DTIIFSNVQERSSAVYQCNASNEYGYLLANA---FVN-VLAEPPRILTPANT-LYQ 465
Query: 1217 TVEIPDETLDVTWYKKK-SVIE---DTEKFTLISDV----KKRTLIIRKCTEDDQCEYTC 1268
+ LD ++ IE + L D+ + TL I +D YTC
Sbjct: 466 VIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTC 525
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
V + K +V + P + + EY + +RGS +V ++ + +D + + +
Sbjct: 526 VARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGS----MVSFECKVK-HDHTLSLTVL 580
Query: 1328 IKKCKHTKPSIDSKSAS---LTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL------ 1378
K PS + + L + V + D+G Y ++++
Sbjct: 581 WLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTP 640
Query: 1379 ----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISVKN 1432
D P+PP + + S+ + W P + NS I +++EY++ W
Sbjct: 641 APVYDVPNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTE 699
Query: 1433 ITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN- 1490
++ TQT+ Q L +Y FR AVN + S SE +E Y ++PT + L +
Sbjct: 700 VSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSE 759
Query: 1491 -----ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXX 1545
IT +P E G Q KV+W + + N
Sbjct: 760 PDNLVITWKPLNGFESN---GPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVP 816
Query: 1546 XXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV 1604
K A ND G E + V+G + + ++ +++ V + L + +P +
Sbjct: 817 YLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRV--NVVNSTLAEVHWDPVPLKSI 874
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSV---IRIKELKRSHS--------SKYTIEASNTAGT 1653
+ G ++ K + + + + + I + ++H S YT+ G
Sbjct: 875 RGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGK 934
Query: 1654 SSVEVTL-KVYDKP-SKPEGPVIMREI--SRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
+ +V++ P P P ++ + + +S+T+EW PP G+ LT+Y + K++P
Sbjct: 935 GEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGI-LTEYTL-KYQPI 992
Query: 1710 NNRWIKVADVDRDVET----YCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
N+ VD + + ++ LN + Y F AQ G + E +
Sbjct: 993 NSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAV 1045
Score = 65.3 bits (152), Expect = 2e-09
Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 8/191 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P+ P + +++ +SV L WT P + SPIT +IIE++ K W V G+
Sbjct: 647 PNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 705
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++ + FR+ A N++G SLP+E+ L K + PTA + N+V
Sbjct: 706 TAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLV 764
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+T ++ P L Y ++ R W V V N K+ + Y+I++
Sbjct: 765 ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSV--VVANVSKYIVSGTPTFVPYLIKVQ 822
Query: 2043 ARNEIGLS-EP 2052
A N++G + EP
Sbjct: 823 ALNDMGFAPEP 833
Score = 57.6 bits (133), Expect = 5e-07
Identities = 63/290 (21%), Positives = 114/290 (39%), Gaps = 12/290 (4%)
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
PP P I +D+S + E + G + +Y+ E ++I TQT IQ
Sbjct: 174 PP--PIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQT-IQQ 230
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN---EDI 1499
+ S +N+ ++ S+T E+Y K ++ + PT P N + + +
Sbjct: 231 KQPISVKVISVDELNDTIAANLSDT-EFYGA-KSSRERPPTFLTPEGNASNKEELRGNVL 288
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L CI G+P P + W ++ L + Y+N Y+CIA N G
Sbjct: 289 SLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGA 348
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + V ++ P + +++ G++ + G P P + W NG +E +
Sbjct: 349 IHHTISVRVKAAPYWITAPQNLVL--SPGEDGTLICRANGNPKPRISWLTNGVPIEIAPD 406
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + K I ++ S+ Y ASN G + V +P +
Sbjct: 407 -DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPR 455
Score = 56.4 bits (130), Expect = 1e-06
Identities = 171/816 (20%), Positives = 308/816 (37%), Gaps = 97/816 (11%)
Query: 721 LPIVLKIKTGEKEPPQVIEPL-KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA-- 777
+P+ K+ +PP + + K I+ E++++ + G P P+ +W +N
Sbjct: 32 VPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDK 91
Query: 778 --LPTKSDGD-THSITILKPKKVKD-EGVYTLKAENSEGIAETSAVIT--VEEP--TEEN 829
L T G T I I+ K + EGVY A N G A ++ ++ P T+E
Sbjct: 92 DPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEK 151
Query: 830 AEP---------------------PLFI---NRFQEITVKEKGTIKLVARVT-RNPVPSI 864
EP P+ N FQ + E+ + L + N +P
Sbjct: 152 LEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPED 211
Query: 865 TWYRNNEIISPSETITQNFDGEN-IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
T R + I TQ + I + + +VD D+ +A+N + +GA+ +
Sbjct: 212 T--REDYICYARFNHTQTIQQKQPISVKVISVDELNDT-----IAANLSDTEFYGAKSSR 264
Query: 924 DVEKVTFVKHLQKSYETEE--GKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRX 981
+ TF+ + EE G + LEC + + T + KE + + +
Sbjct: 265 E-RPPTFLTPEGNASNKEELRGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTVYKNFE 322
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETS---TMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
D G +CI K+ + T+ V + P +I Q+ + + L
Sbjct: 323 KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLIC 382
Query: 1039 EINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES-- 1095
N + W +G I+ + D ++ + N Y C +E
Sbjct: 383 RANGNPKPRISWLTNGVPIEIAPD--DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGY 440
Query: 1096 --CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNH 1151
A V V+ PP I+T N+ G L + WFK H
Sbjct: 441 LLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSAL--H 498
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFIL 1207
+ + + L+I D G Y+C ++G +K L +++P+ + ++ PE+ +
Sbjct: 499 EDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPT--WIVKQPEYAV 556
Query: 1208 VPANTDAYLTVEIP-DETLDVT--WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQC 1264
V + ++ D TL +T W K + E+FT V K L++ ++DD
Sbjct: 557 VQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFT----VDKDHLVVADVSDDDSG 612
Query: 1265 EYTCV---LLDAKSTTKLKVEVVEFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPN 1318
YTCV LD+ S + + V P Y+ + ++ + V P +
Sbjct: 613 TYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDD 672
Query: 1319 DEWIVNSKIIK-KCKHTKPSI----DSKSASLTIKKVENTDAGIYKLRL--ENNCGHA-D 1370
+ + II+ + KP + S + T +++ + Y R+ N+ G +
Sbjct: 673 NNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLP 732
Query: 1371 VEMNVTILDKPSPPGK-PNILE---IDSSSINICWDEPEN--TGNSTIIYYVVEYQEID- 1423
E + L K S P K P +E + ++ I W +P N N + Y V +++ D
Sbjct: 733 SEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITW-KPLNGFESNGPGLQYKVSWRQKDG 791
Query: 1424 TTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
EW SV ++ + T Y + A+N++
Sbjct: 792 DDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDM 827
Score = 41.9 bits (94), Expect = 0.024
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 524 GSTVQFECQVEGYPRPQIT--WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V FEC+V+ +T W + + + F + D D+ LV+ +V +D+GT+
Sbjct: 560 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV--DKDH---LVVADVSDDDSGTY 614
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA S++ L V AP
Sbjct: 615 TCVANTTLDSVSASAVLSVVAP 636
Score = 41.1 bits (92), Expect = 0.042
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 7/109 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE----WISVK-NITK 1435
PS P I+ S+ + WD P + N + Y ++YQ I++T + +K K
Sbjct: 952 PSAPSSLKIVNPTLDSLTLEWDPPSHP-NGILTEYTLKYQPINSTHELGPLVDLKIPANK 1010
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
T+ +++NL ++ Y+F YA S + T E + E I P V
Sbjct: 1011 TRWTLKNLNFSTRYKFYFYAQTSAG-SGSQITEEAVTTVDEAGILPPDV 1058
Score = 37.1 bits (82), Expect = 0.69
Identities = 38/146 (26%), Positives = 58/146 (39%), Gaps = 14/146 (9%)
Query: 1476 ETKIQSPTV-EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG-------KKLKTAK- 1526
E +Q PT+ ++ K+ +P E+I + C G P P +W R+G L T K
Sbjct: 40 EDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP 99
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHK 1585
T Y+C A N+ G V + VV + P+ T E ++
Sbjct: 100 GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWT--KEKLEPITL 157
Query: 1586 VGDEWLVTAVIE--GIPPPEVIWYKN 1609
+ LV G+PPP + W N
Sbjct: 158 QSGQSLVLPCRPPIGLPPPIIFWMDN 183
>AF172277-1|AAF22282.1| 1308|Homo sapiens NgCAM-related related cell
adhesion molecule protein.
Length = 1308
Score = 93.9 bits (223), Expect = 6e-18
Identities = 114/478 (23%), Positives = 194/478 (40%), Gaps = 48/478 (10%)
Query: 507 SMAPIFV-EKLRPKHTPDGSTVQFECQVE-GYPRPQITWFRQTAIIKP-SQDFQMYYDDD 563
S +P++ EKL P G ++ C+ G P P I W + P S+ + D
Sbjct: 142 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGD 201
Query: 564 NVATLVIREVFPEDAGT-FTCVAK-NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
L V PED + C A+ N + V+ D ++ T+
Sbjct: 202 ----LYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELND-TIAANLSDTE 256
Query: 622 XXXXADILEGIPPTF-SKKPKAQYVDE--GSDILLECRLVAIPEPDIAWLFKGEEIVPDE 678
E PPTF + + A +E G+ + LEC +P P I W K + ++P +
Sbjct: 257 FYGAKSSRER-PPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWA-KEDGMLP-K 313
Query: 679 NISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
N +V + L+I +V + G Y +A N G I +++K P I
Sbjct: 314 NRTVYKNFE-----KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA----PYWI 364
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP----TKSDGDTHSITILKP 794
+++++ GE L + GNP+P I+W N P++ P K DGDT I
Sbjct: 365 TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDT---IIFSN 421
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-TVKEKGTIKLV 853
+ + VY A N G +A + V AEPP + + V L
Sbjct: 422 VQERSSAVYQCNASNEYGYLLANAFVNV------LAEPPRILTPANTLYQVIANRPALLD 475
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAG 913
+P+P+I W++ + + E I + +E+ + DS +G Y CVA N G
Sbjct: 476 CAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDS---TGTYTCVARNKLG 532
Query: 914 KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH----TVSTKWYHNKKEI 967
+ + V ++++ T++ + + G V EC+ H +++ W + +E+
Sbjct: 533 MAKN--EVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL 588
Score = 89.4 bits (212), Expect = 1e-16
Identities = 117/529 (22%), Positives = 207/529 (39%), Gaps = 53/529 (10%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENR---XXXXXXXXXXXXX 1545
+N+ P ED L C G P+P+++W +G ++ A +
Sbjct: 368 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSS 427
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C A N++G + + V + +P ++ + + L+ G P P +
Sbjct: 428 AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIE 487
Query: 1606 WYK--NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY 1663
W+K G+ L D I + + I ++ + YT A N G + EV L++
Sbjct: 488 WFKGAKGSALHED----IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK 543
Query: 1664 DKP---SKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE--PDNNRWIKVAD 1718
D +PE V+ R V+ E K D L LT ++ + P + R+
Sbjct: 544 DPTWIVKQPEYAVVQR---GSMVSFECKVK-HDHTLSLTVLWLKDNRELPSDERF----T 595
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT-----ALDVPSXXXXX 1773
VD+D + ++++ + +A + A +V T DVP+
Sbjct: 596 VDKD--HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDL 653
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXARIQ-KL 1829
+D +SV ++W P + N SPI + +E + K W Q KL
Sbjct: 654 ELTDQLD-KSVQLSWTPGDDN-NSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKL 711
Query: 1830 SINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEP 1889
S Y FR+ A N IG SLP + ++ + K P P S ++ + W +P
Sbjct: 712 SPYVNYSFRVMAVNSIGKSLPSEASEQY-LTKASEPDKNPTAVEGLGSEPDNLVITW-KP 769
Query: 1890 ----ESNGGSPITNYIIEFKTVKG-KSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAEN 1944
ESNG P Y + ++ G WT +V +V ++ + + ++ A N
Sbjct: 770 LNGFESNG--PGLQYKVSWRQKDGDDEWTSVVV--ANVSKYIVSGTPTFVPYLIKVQALN 825
Query: 1945 TVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
+G + + + H+ P AP +R+ N+V ++ WD
Sbjct: 826 DMGFA----PEPAVVMGHSGEDLPMVAPGNVRV---NVVNSTLAEVHWD 867
Score = 84.6 bits (200), Expect = 3e-15
Identities = 135/647 (20%), Positives = 259/647 (40%), Gaps = 74/647 (11%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 45 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 161
Query: 751 SVILSAQ-VVGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 162 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 218
Query: 804 TLKAENSEGIAE----TSAVITVEE----------PTE------ENAEPPLFINRFQEIT 843
+ +++ I + + VI+V+E TE PP F+ +
Sbjct: 219 YARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNAS 278
Query: 844 VKE--KGTIKLVARVTRN-PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEID 900
KE +G + + + P P I W + + ++ + T+ +NF+ + ++++ SE D
Sbjct: 279 NKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-KTLQIIHV---SEAD 334
Query: 901 SGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKW 960
SG+Y+C+A N+ G H V + E T+I + W
Sbjct: 335 SGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISW 394
Query: 961 YHN--KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKE 1014
N EI+ D I +G V +C ++ + + V
Sbjct: 395 LTNGVPIEIAPDDPSRKI-DGDTIIFSNVQERSS--AVYQCNASNEYGYLLANAFVNVLA 451
Query: 1015 TIPEFIRKLQD-FEVKEKDVAILEVE-INSETADVVWERDGEIIKPKKNKYDFEKRGHIR 1072
P + ++V A+L+ S + W + + ++ Y + G
Sbjct: 452 EPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENG--- 508
Query: 1073 KLYIRNTSVHDEGEYSCILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIE 1129
L I G Y+C+ R++ A+ V ++ P I+ + + V +G+ +FE +
Sbjct: 509 TLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECK 568
Query: 1130 LTKGDAL---VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS--- 1183
+ L V W KD E+ + T+D K L + D DD+G Y+C +
Sbjct: 569 VKHDHTLSLTVLWLKDNRELPSDE--RFTVD--KDHLVVADVSDDDSGTYTCVANTTLDS 624
Query: 1184 -KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTW 1229
+A+L+V P+ P + + D LT ++ D+++ ++W
Sbjct: 625 VSASAVLSVVAPT---PTPAPVYDVPNPPFDLELTDQL-DKSVQLSW 667
Score = 76.6 bits (180), Expect = 9e-13
Identities = 165/773 (21%), Positives = 294/773 (38%), Gaps = 84/773 (10%)
Query: 1044 TADVVWERDGEIIKPKKNKY-DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
T + W ++ ++ + Y +FEK L I + S D G Y CI ++ T+
Sbjct: 299 TPIIYWAKEDGMLPKNRTVYKNFEKT-----LQIIHVSEADSGNYQCIAKNALGAIHHTI 353
Query: 1103 ---VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFS-NHIQLTI 1156
V+ P IT QN ++ G T I G+ R W +G I+ + + I
Sbjct: 354 SVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVPIEIAPDDPSRKI 412
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
DG + + + Y C N + +N L P IL PANT Y
Sbjct: 413 DG--DTIIFSNVQERSSAVYQCNASNEYGYLLANA---FVN-VLAEPPRILTPANT-LYQ 465
Query: 1217 TVEIPDETLDVTWYKKK-SVIE---DTEKFTLISDV----KKRTLIIRKCTEDDQCEYTC 1268
+ LD ++ IE + L D+ + TL I +D YTC
Sbjct: 466 VIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTC 525
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYEREYRI-KRGSDVTLLVDYQAFPQPNDEWIVNSKI 1327
V + K +V + P + + EY + +RGS +V ++ + +D + + +
Sbjct: 526 VARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGS----MVSFECKVK-HDHTLSLTVL 580
Query: 1328 IKKCKHTKPSIDSKSAS---LTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL------ 1378
K PS + + L + V + D+G Y ++++
Sbjct: 581 WLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTP 640
Query: 1379 ----DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISVKN 1432
D P+PP + + S+ + W P + NS I +++EY++ W
Sbjct: 641 APVYDVPNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTE 699
Query: 1433 ITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKN- 1490
++ TQT+ Q L +Y FR AVN + S SE +E Y ++PT + L +
Sbjct: 700 VSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSE 759
Query: 1491 -----ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXX 1545
IT +P E G Q KV+W + + N
Sbjct: 760 PDNLVITWKPLNGFESN---GPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVP 816
Query: 1546 XXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEV 1604
K A ND G E + V+G + + ++ +++ V + L + +P +
Sbjct: 817 YLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRV--NVVNSTLAEVHWDPVPLKSI 874
Query: 1605 IWYKNGNKLENDKEYNITTKEKTSV---IRIKELKRSHS--------SKYTIEASNTAGT 1653
+ G ++ K + + + + + I + ++H S YT+ G
Sbjct: 875 RGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGK 934
Query: 1654 SSVEVTL-KVYDKP-SKPEGPVIMREI--SRESVTIEWKPPLDDGGLELTKYAIEKHEPD 1709
+ +V++ P P P ++ + + +S+T+EW PP G+ LT+Y + K++P
Sbjct: 935 GEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGI-LTEYTL-KYQPI 992
Query: 1710 NNRWIKVADVDRDVET----YCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
N+ VD + + ++ LN + Y F AQ G + E +
Sbjct: 993 NSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAV 1045
Score = 65.3 bits (152), Expect = 2e-09
Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 8/191 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P+ P + +++ +SV L WT P + SPIT +IIE++ K W V G+
Sbjct: 647 PNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 705
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++ + FR+ A N++G SLP+E+ L K + PTA + N+V
Sbjct: 706 TAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLV 764
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+T ++ P L Y ++ R W V V N K+ + Y+I++
Sbjct: 765 ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSV--VVANVSKYIVSGTPTFVPYLIKVQ 822
Query: 2043 ARNEIGLS-EP 2052
A N++G + EP
Sbjct: 823 ALNDMGFAPEP 833
Score = 57.6 bits (133), Expect = 5e-07
Identities = 63/290 (21%), Positives = 114/290 (39%), Gaps = 12/290 (4%)
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
PP P I +D+S + E + G + +Y+ E ++I TQT IQ
Sbjct: 174 PP--PIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQT-IQQ 230
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN---EDI 1499
+ S +N+ ++ S+T E+Y K ++ + PT P N + + +
Sbjct: 231 KQPISVKVISVDELNDTIAANLSDT-EFYGA-KSSRERPPTFLTPEGNASNKEELRGNVL 288
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L CI G+P P + W ++ L + Y+N Y+CIA N G
Sbjct: 289 SLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGA 348
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + V ++ P + +++ G++ + G P P + W NG +E +
Sbjct: 349 IHHTISVRVKAAPYWITAPQNLVL--SPGEDGTLICRANGNPKPRISWLTNGVPIEIAPD 406
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + K I ++ S+ Y ASN G + V +P +
Sbjct: 407 -DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPR 455
Score = 56.4 bits (130), Expect = 1e-06
Identities = 171/816 (20%), Positives = 308/816 (37%), Gaps = 97/816 (11%)
Query: 721 LPIVLKIKTGEKEPPQVIEPL-KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA-- 777
+P+ K+ +PP + + K I+ E++++ + G P P+ +W +N
Sbjct: 32 VPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDK 91
Query: 778 --LPTKSDGD-THSITILKPKKVKD-EGVYTLKAENSEGIAETSAVIT--VEEP--TEEN 829
L T G T I I+ K + EGVY A N G A ++ ++ P T+E
Sbjct: 92 DPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEK 151
Query: 830 AEP---------------------PLFI---NRFQEITVKEKGTIKLVARVT-RNPVPSI 864
EP P+ N FQ + E+ + L + N +P
Sbjct: 152 LEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPED 211
Query: 865 TWYRNNEIISPSETITQNFDGEN-IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
T R + I TQ + I + + +VD D+ +A+N + +GA+ +
Sbjct: 212 T--REDYICYARFNHTQTIQQKQPISVKVISVDELNDT-----IAANLSDTEFYGAKSSR 264
Query: 924 DVEKVTFVKHLQKSYETEE--GKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRX 981
+ TF+ + EE G + LEC + + T + KE + + +
Sbjct: 265 E-RPPTFLTPEGNASNKEELRGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTVYKNFE 322
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETS---TMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
D G +CI K+ + T+ V + P +I Q+ + + L
Sbjct: 323 KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLIC 382
Query: 1039 EINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES-- 1095
N + W +G I+ + D ++ + N Y C +E
Sbjct: 383 RANGNPKPRISWLTNGVPIEIAPD--DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGY 440
Query: 1096 --CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNH 1151
A V V+ PP I+T N+ G L + WFK H
Sbjct: 441 LLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSAL--H 498
Query: 1152 IQLTIDGKKQKLKIYDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPEFIL 1207
+ + + L+I D G Y+C ++G +K L +++P+ + ++ PE+ +
Sbjct: 499 EDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPT--WIVKQPEYAV 556
Query: 1208 VPANTDAYLTVEIP-DETLDVT--WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQC 1264
V + ++ D TL +T W K + E+FT V K L++ ++DD
Sbjct: 557 VQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFT----VDKDHLVVADVSDDDSG 612
Query: 1265 EYTCV---LLDAKSTTKLKVEVVEFPPKIVDYE---REYRIKRGSDVTLLVDYQAFPQPN 1318
YTCV LD+ S + + V P Y+ + ++ + V P +
Sbjct: 613 TYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDD 672
Query: 1319 DEWIVNSKIIK-KCKHTKPSI----DSKSASLTIKKVENTDAGIYKLRL--ENNCGHA-D 1370
+ + II+ + KP + S + T +++ + Y R+ N+ G +
Sbjct: 673 NNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLP 732
Query: 1371 VEMNVTILDKPSPPGK-PNILE---IDSSSINICWDEPEN--TGNSTIIYYVVEYQEID- 1423
E + L K S P K P +E + ++ I W +P N N + Y V +++ D
Sbjct: 733 SEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITW-KPLNGFESNGPGLQYKVSWRQKDG 791
Query: 1424 TTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
EW SV ++ + T Y + A+N++
Sbjct: 792 DDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDM 827
Score = 41.9 bits (94), Expect = 0.024
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 524 GSTVQFECQVEGYPRPQIT--WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V FEC+V+ +T W + + + F + D D+ LV+ +V +D+GT+
Sbjct: 560 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV--DKDH---LVVADVSDDDSGTY 614
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA S++ L V AP
Sbjct: 615 TCVANTTLDSVSASAVLSVVAP 636
Score = 41.1 bits (92), Expect = 0.042
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 7/109 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE----WISVK-NITK 1435
PS P I+ S+ + WD P + N + Y ++YQ I++T + +K K
Sbjct: 952 PSAPSSLKIVNPTLDSLTLEWDPPSHP-NGILTEYTLKYQPINSTHELGPLVDLKIPANK 1010
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
T+ +++NL ++ Y+F YA S + T E + E I P V
Sbjct: 1011 TRWTLKNLNFSTRYKFYFYAQTSAG-SGSQITEEAVTTVDEAGILPPDV 1058
Score = 37.1 bits (82), Expect = 0.69
Identities = 38/146 (26%), Positives = 58/146 (39%), Gaps = 14/146 (9%)
Query: 1476 ETKIQSPTV-EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG-------KKLKTAK- 1526
E +Q PT+ ++ K+ +P E+I + C G P P +W R+G L T K
Sbjct: 40 EDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP 99
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHK 1585
T Y+C A N+ G V + VV + P+ T E ++
Sbjct: 100 GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWT--KEKLEPITL 157
Query: 1586 VGDEWLVTAVIE--GIPPPEVIWYKN 1609
+ LV G+PPP + W N
Sbjct: 158 QSGQSLVLPCRPPIGLPPPIIFWMDN 183
>AB046788-1|BAB13394.1| 1380|Homo sapiens KIAA1568 protein protein.
Length = 1380
Score = 93.9 bits (223), Expect = 6e-18
Identities = 82/312 (26%), Positives = 130/312 (41%), Gaps = 25/312 (8%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
PTF ++P Q V E + C++ P+P + W K + +P I+ D
Sbjct: 227 PTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK-KDDADLPRGRYD--IKDDY----- 278
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVI 753
L+I EGTY +A NR G+ L ++ PPQ + + IV QG +V
Sbjct: 279 TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA----PPQFVVRPRDQIVAQGRTVT 334
Query: 754 LSAQVVGNPRPTITWCKN--------NKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+ GNP+P + W K N+P + S T +TI ++ D G Y
Sbjct: 335 FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQR-SDAGYYIC 393
Query: 806 KAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSIT 865
+A G A + V + + PP+ + T+ GT L + T +P+P I+
Sbjct: 394 QALTVAGSILAKAQLEVTDVLTDRP-PPIILQGPANQTLAVDGTALLKCKATGDPLPVIS 452
Query: 866 WYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDV 925
W + P E L I N+ D+G Y CVA++S+G++S A + +
Sbjct: 453 WLKEG-FTFPGRDPRATIQ-EQGTLQIKNLRIS-DTGTYTCVATSSSGETSWSAVLDVTE 509
Query: 926 EKVTFVKHLQKS 937
T K+ S
Sbjct: 510 SGATISKNYDLS 521
Score = 81.0 bits (191), Expect = 4e-14
Identities = 88/418 (21%), Positives = 161/418 (38%), Gaps = 29/418 (6%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPS--IDSKS 1342
+FPP+IV++ + + +G TL + P P EW + + ++ K S + S
Sbjct: 30 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 89
Query: 1343 ASLTIKKV-----ENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNILEIDS 1394
SL ++ D G Y N G A + + V +L +++
Sbjct: 90 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 149
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAY 1454
+ P TI + + + D E IS++ + I N + + + +
Sbjct: 150 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG---GKLMISNTRKSDAGMYTCV 206
Query: 1455 AVNEVDISDASETTEYYKVIKETKIQSPT-VEKPLKNITTEPNEDIELTCIFGGVPQPKV 1513
N V D S+ E T + PT + +P+ + E E +E C G PQP V
Sbjct: 207 GTNMVGERD-SDPAEL------TVFERPTFLRRPINQVVLE-EEAVEFRCQVQGDPQPTV 258
Query: 1514 TWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVI 1573
W +D L + ++ Y CIA N G++E S + ++ P
Sbjct: 259 RWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 318
Query: 1574 TISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNK---LENDKEY--NITTKEKTS 1628
+ D Q G +G P P V W K G++ N + + + T
Sbjct: 319 VVRPRD--QIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 376
Query: 1629 VIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+ I ++RS + Y +A AG+ + L+V D + P+I++ + +++ ++
Sbjct: 377 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 434
Score = 79.0 bits (186), Expect = 2e-13
Identities = 82/334 (24%), Positives = 132/334 (39%), Gaps = 34/334 (10%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDE----NISVAIE 685
E PP + P V +G L C+ P P I W GE + D+ + + +
Sbjct: 29 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 88
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE-----ASLPIVLKIKTGEKEPPQVIEP 740
S + ++ K EG+Y VA N GE ASL + L + P V
Sbjct: 89 SGSLFFLRIVHGRRSKP-DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV--- 144
Query: 741 LKSMIVRQGESVILSAQVV-GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKD 799
+V GE IL Q G+P PTI W K+ + + + I +K D
Sbjct: 145 ----VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRK-SD 199
Query: 800 EGVYTLKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
G+YT N G ++ A +TV E P F+ R V E+ ++ +V
Sbjct: 200 AGMYTCVGTNMVGERDSDPAELTV-------FERPTFLRRPINQVVLEEEAVEFRCQVQG 252
Query: 859 NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHG 918
+P P++ W +++ ++ +D ++ + D G Y C+A N GK
Sbjct: 253 DPQPTVRWKKDD-----ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEAS 307
Query: 919 ARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT 952
A +T+ V+ + +G+TV C+T
Sbjct: 308 ATLTVRAPPQFVVR--PRDQIVAQGRTVTFPCET 339
Score = 72.1 bits (169), Expect = 2e-11
Identities = 114/495 (23%), Positives = 195/495 (39%), Gaps = 46/495 (9%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSIT 790
E PP+++E +IV +GE L+ + G P PTI W K+ + V+ K D +H +
Sbjct: 29 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVET--DKDDPRSHRML 86
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENA--EPPLFINRFQ----EITV 844
+ V+ +++ EG A + E NA E L + F+ ++ V
Sbjct: 87 LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 146
Query: 845 KEKGTIKLVARVTR-NPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
L + R +P P+I W ++ I E + +L+I+N + D+G
Sbjct: 147 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRGGKLMISNT-RKSDAGM 202
Query: 904 YKCVASNSAG-KSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYH 962
Y CV +N G + S A +T+ E+ TF++ EE + V CQ
Sbjct: 203 YTCVGTNMVGERDSDPAELTV-FERPTFLRRPINQVVLEE-EAVEFRCQVQGDPQPTVRW 260
Query: 963 NKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVVKETIPE 1018
K + R I++ D G CI +++ E S L V+ P+
Sbjct: 261 KKDDADLPRGRYDIKD--DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP-PQ 317
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSETADVV-WERDG--EIIKPKKNKYDFEK--RGHIRK 1073
F+ + +D V + E V W+++G ++ P + + +
Sbjct: 318 FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 377
Query: 1074 LYIRNTSVHDEGEYSC----ILRDESCTAEVTVVEL-----PPEIITRLQNQKVNKGNKA 1124
L I N D G Y C + A++ V ++ PP I+ NQ + A
Sbjct: 378 LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA 437
Query: 1125 TFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC---- 1178
+ + T GD L + W K+G F ++ L+I + + D G Y+C
Sbjct: 438 LLKCKAT-GDPLPVISWLKEG--FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATS 494
Query: 1179 EVGNSKCTAILTVEE 1193
G + +A+L V E
Sbjct: 495 SSGETSWSAVLDVTE 509
Score = 66.9 bits (156), Expect = 7e-10
Identities = 45/195 (23%), Positives = 80/195 (41%), Gaps = 3/195 (1%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY- 691
PP F +P+ Q V +G + C P+P + W +G + + N S +
Sbjct: 315 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 374
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQG 749
L ITN+++ G Y A+ G L++ ++ PP +++ + +
Sbjct: 375 TGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 434
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ +L + G+P P I+W K ++ +K ++ D G YT A +
Sbjct: 435 GTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATS 494
Query: 810 SEGIAETSAVITVEE 824
S G SAV+ V E
Sbjct: 495 SSGETSWSAVLDVTE 509
Score = 60.5 bits (140), Expect = 6e-08
Identities = 103/477 (21%), Positives = 181/477 (37%), Gaps = 57/477 (11%)
Query: 1315 PQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVE-M 1373
P+P W K+ K + SI + L I +DAG+Y N G D +
Sbjct: 163 PEPTIYW-KKDKVRIDDKEERISI--RGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPA 219
Query: 1374 NVTILDKPSPPGKP-NILEIDSSSINI-CWDEPENTGNSTIIYYVVEYQEIDTTEWISVK 1431
+T+ ++P+ +P N + ++ ++ C + + T+ + + D + +
Sbjct: 220 ELTVFERPTFLRRPINQVVLEEEAVEFRC--QVQGDPQPTVRW------KKDDADLPRGR 271
Query: 1432 NITKTQTSIQNLKTNSSYR--FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
K +++ KT S+ + A N V +AS T + V +P
Sbjct: 272 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT-------VRAPPQFVVRPRD 324
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKK---------LKTAKATYENRXXXXXXXX 1540
I + + C G PQP V W ++G + ++ +
Sbjct: 325 QIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 383
Query: 1541 XXXXXXXYKCIAFNDHGEVETSCVVGIQQ----KPVITISNEDIKQKHKVGDEWLVTAVI 1596
Y C A G + + + +P I Q V L+
Sbjct: 384 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 443
Query: 1597 EGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSV 1656
G P P + W K G ++ T +E+ ++IK L+ S + YT A++++G +S
Sbjct: 444 TGDPLPVISWLKEGFTFPG-RDPRATIQEQ-GTLQIKNLRISDTGTYTCVATSSSGETSW 501
Query: 1657 EVTLKVY-------------DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAI 1703
L V D P P P + ++++ SVT+ W+P G L + Y I
Sbjct: 502 SAVLDVTESGATISKNYDLSDLPGPPSKPQVT-DVTKNSVTLSWQPGTP-GTLPASAYII 559
Query: 1704 EKHEPD-NNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPI 1758
E +N W VA+ + Y ++ L N Y+F V A NP G S+ + S+P+
Sbjct: 560 EAFSQSVSNSWQTVANHVKTT-LYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPV 615
Score = 58.4 bits (135), Expect = 3e-07
Identities = 58/222 (26%), Positives = 88/222 (39%), Gaps = 34/222 (15%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA--IIKPSQDFQ--MYYDDDNV 565
P FV + R + G TV F C+ +G P+P + W ++ + ++ P+Q Q
Sbjct: 316 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 375
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXX 625
L I + DAG + C A AG + +L V L+D
Sbjct: 376 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP----------------- 418
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
PP + P Q + LL+C+ P P I+WL +G P + I+
Sbjct: 419 -------PPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF-PGRDPRATIQ 470
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L+I N++ GTYT VA + GE S VL +
Sbjct: 471 EQ-----GTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 507
Score = 55.2 bits (127), Expect = 2e-06
Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 14/110 (12%)
Query: 494 KLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPS 553
+L VFE+PT + + + +E+ V+F CQV+G P+P + W + A +
Sbjct: 220 ELTVFERPTFLRRPINQVVLEE---------EAVEFRCQVQGDPQPTVRWKKDDADLPRG 270
Query: 554 QDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
+ YD + TL I++ D GT+ C+A+N G ++ L V AP
Sbjct: 271 R-----YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 315
Score = 54.0 bits (124), Expect = 6e-06
Identities = 96/418 (22%), Positives = 162/418 (38%), Gaps = 43/418 (10%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKR----GHI 1071
P + D V + + L + T + W +DGE ++ K+ + G +
Sbjct: 33 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 92
Query: 1072 RKLYIRN--TSVHDEGEYSCILRDE-----SCTAEVTVVELPPEIITRLQNQKVNKGNKA 1124
L I + S DEG Y C+ R+ S A + V L + + V G A
Sbjct: 93 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 152
Query: 1125 TFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
E + +G + + W KD I +++I G K L I + DAG Y+C N
Sbjct: 153 ILECQPPRGHPEPTIYWKKDKVRIDDKEE-RISIRGGK--LMISNTRKSDAGMYTCVGTN 209
Query: 1183 -----SKCTAILTV-EEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVI 1236
A LTV E P+ LR P +V ++ + +KK
Sbjct: 210 MVGERDSDPAELTVFERPTF---LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 266
Query: 1237 EDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYER 1295
++ + D TL I+K D+ Y C+ + + + V PP+ V R
Sbjct: 267 LPRGRYDIKDDY---TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPR 323
Query: 1296 EYRIKRGSDVTLLVDYQAFPQPNDEWIV--NSKIIKKCKHTKPSID---SKSASLTIKKV 1350
+ + +G VT + + PQP W + ++ + +P+ S + LTI +
Sbjct: 324 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 383
Query: 1351 ENTDAGIYKLRLENNCG----HADVEMNVTILDKPSP---PGKPN-ILEIDSSSINIC 1400
+ +DAG Y + G A +E+ + D+P P G N L +D +++ C
Sbjct: 384 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 441
Score = 41.1 bits (92), Expect = 0.042
Identities = 38/118 (32%), Positives = 56/118 (47%), Gaps = 15/118 (12%)
Query: 1865 PPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSVH 1923
PPS+P+ V++ T SVTL W +P + G P + YIIE F SW TV V
Sbjct: 526 PPSKPQ---VTDVTKNSVTLSW-QPGTPGTLPASAYIIEAFSQSVSNSWQ---TVANHVK 578
Query: 1924 E--HCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMV 1978
+ + ++ +F + A N G+S P+ S VR + SPP ++ R V
Sbjct: 579 TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQD----ISPPAQGVDHRQV 632
Score = 35.9 bits (79), Expect = 1.6
Identities = 29/109 (26%), Positives = 44/109 (40%), Gaps = 8/109 (7%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQD----FQMYY 560
++ P VE G C+ EG P P I W++ ++ +D +M
Sbjct: 28 QEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL 87
Query: 561 DDDNVATLVI---REVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
++ L I R P D G++ CVA+N G A S + A L D
Sbjct: 88 PSGSLFFLRIVHGRRSKP-DEGSYVCVARNYLGEAVSRNASLEVALLRD 135
>X85337-1|CAA59685.1| 991|Homo sapiens myosin light chain kinase
protein.
Length = 991
Score = 93.5 bits (222), Expect = 7e-18
Identities = 52/200 (26%), Positives = 90/200 (45%), Gaps = 1/200 (0%)
Query: 1287 PPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLT 1346
PP+I+ + + +++ G V L W+ K I++ +H K + LT
Sbjct: 315 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLT 374
Query: 1347 IKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNILEIDSSSINICWDEPE 1405
I G Y L +EN G ++N++++DKP PP G P +I SSS+ + W
Sbjct: 375 ILAGRQEHCGCYTLLVENKSGSRQAQVNLSVVDKPDPPAGTPCASDIRSSSLTLSWYGSS 434
Query: 1406 NTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDAS 1465
G S + Y +E + W + T ++Q+L + Y+FR A+N S+ S
Sbjct: 435 YDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPS 494
Query: 1466 ETTEYYKVIKETKIQSPTVE 1485
+ +E V ++ + VE
Sbjct: 495 QESELTTVGEKPEEPKDEVE 514
Score = 90.2 bits (214), Expect = 7e-17
Identities = 41/116 (35%), Positives = 66/116 (56%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR 545
+KL + E E+ + P F + +R +GS +F+C++EGYP P++ WF+
Sbjct: 862 EKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFK 921
Query: 546 QTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 922 DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 977
Score = 81.4 bits (192), Expect = 3e-14
Identities = 51/176 (28%), Positives = 80/176 (45%), Gaps = 3/176 (1%)
Query: 1582 QKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSS 1641
QK + G+ + + G P W K +++ + + E S + I ++ H
Sbjct: 325 QKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAGRQEHCG 384
Query: 1642 KYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKY 1701
YT+ N +G+ +V L V DKP P G +I S+T+ W DGG + Y
Sbjct: 385 CYTLLVENKSGSRQAQVNLSVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 444
Query: 1702 AIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESE 1756
+IE + N W ++A ++ +Q L + EY FRV A N G SE + ESE
Sbjct: 445 SIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 498
Score = 66.5 bits (155), Expect = 1e-09
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Query: 503 SEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDD 562
SE Q AP F +KL+ H +G + +CQV P I W +K ++ F + +
Sbjct: 169 SESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQE 227
Query: 563 DNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV-EAPLSDH 607
++ ++ I + PED G + CVAKN AG A + ++ V +AP S++
Sbjct: 228 GSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASEN 273
Score = 58.0 bits (134), Expect = 3e-07
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 409 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 466
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
FN++DL +H Y R+ A N G SEP + E V GE EEP ++ EV
Sbjct: 467 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTV--GE---KPEEPKDEVEV 515
Score = 56.0 bits (129), Expect = 1e-06
Identities = 39/152 (25%), Positives = 67/152 (44%), Gaps = 6/152 (3%)
Query: 1762 TALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXX 1820
+ +D P I + S+ ++W+ S +GGS + Y +EI K WK
Sbjct: 404 SVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCR 463
Query: 1821 XXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFV-VSESTS 1879
+Q L + Y+FR+ A N GTS P + T+G+ P +P++ V VS+
Sbjct: 464 STSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPKDEVEVSDDDE 520
Query: 1880 RSVTLKWTEPESNGGSPITN-YIIEFKTVKGK 1910
+ + + N +++ Y IE + GK
Sbjct: 521 KEPEVDYRTVTINTEQKVSDFYDIEERLGSGK 552
Score = 54.8 bits (126), Expect = 3e-06
Identities = 38/132 (28%), Positives = 63/132 (47%), Gaps = 5/132 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + L+ + V +G+ ++L QV +P TI W N K +K + +G S++I
Sbjct: 176 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 235
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-PTEENAEPPLFINRFQEITVKEKGTI 850
K +D G+Y A+N G AE S +TV++ P EN + P +R + +
Sbjct: 236 EKALP-EDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSPPPVLGT 294
Query: 851 KLVARVTRNPVP 862
+ A V + P P
Sbjct: 295 ESDATVKKKPAP 306
Score = 54.0 bits (124), Expect = 6e-06
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
E+ +E P F + Q++ V E + L +V+ +P +I W N + + ++ I +
Sbjct: 166 EKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILS 225
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTID 924
+G + I E D G YKCVA N AG++ +VT+D
Sbjct: 226 QEGSLCSVSIEKALPE-DRGLYKCVAKNDAGQAECSCQVTVD 266
Score = 52.8 bits (121), Expect = 1e-05
Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 1015 TIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYDFEKRGHIRK 1073
T P F +KLQD V E +L+ +++S+ A ++W +G+ +K K + G +
Sbjct: 174 TAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTK-FIILSQEGSLCS 232
Query: 1074 LYIRNTSVHDEGEYSCILRDES----CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIE 1129
+ I D G Y C+ ++++ C+ +VTV + P T+ K + + +
Sbjct: 233 VSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSPPPVL 292
Query: 1130 LTKGDALVR 1138
T+ DA V+
Sbjct: 293 GTESDATVK 301
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 884 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 941
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 942 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 981
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 4/135 (2%)
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
+NLK+ S + N+V+ T + E++ +P ++ L+++ + +
Sbjct: 135 ENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLL 194
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXX----XXXYKCIAFNDH 1556
L C P + W +GK LKT K ++ YKC+A ND
Sbjct: 195 LQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDA 254
Query: 1557 GEVETSCVVGIQQKP 1571
G+ E SC V + P
Sbjct: 255 GQAECSCQVTVDDAP 269
Score = 46.8 bits (106), Expect = 9e-04
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSIT 790
PPQ+I+ + VR GESV L +V G T TW K K ++ + ++ + +T
Sbjct: 315 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLT 374
Query: 791 ILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPP 833
IL ++ + G YTL EN G + ++V + + A P
Sbjct: 375 ILAGRQ-EHCGCYTLLVENKSGSRQAQVNLSVVDKPDPPAGTP 416
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 4/101 (3%)
Query: 1875 SESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKD 1934
S+ S S+TL W +GGS + +Y IE K+W ++ T + ++++
Sbjct: 419 SDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFN--VQDLLPDH 476
Query: 1935 EIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
E FR+ A N G S P SQ L P P +E+
Sbjct: 477 EYKFRVRAINVYGTSEP--SQESELTTVGEKPEEPKDEVEV 515
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
L AE E +E + +E EE P F +++ V E + ++ P P
Sbjct: 859 LNAEKLE--SEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPE 916
Query: 864 ITWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A +
Sbjct: 917 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELI 975
Query: 923 ID 924
++
Sbjct: 976 VE 977
Score = 44.0 bits (99), Expect = 0.006
Identities = 23/88 (26%), Positives = 40/88 (45%)
Query: 1295 REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTD 1354
++ + G + L + P W +N K +K K S + S++I+K D
Sbjct: 183 QDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPED 242
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPS 1382
G+YK +N+ G A+ VT+ D P+
Sbjct: 243 RGLYKCVAKNDAGQAECSCQVTVDDAPA 270
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/90 (30%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+G P F +K + +V EG +LL+C++ + P I W G+ + + I ++ E +
Sbjct: 172 QGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL- 230
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEA 719
CSV I G Y VA N G+A
Sbjct: 231 --CSV-SIEKALPEDRGLYKCVAKNDAGQA 257
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 886 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 945
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 946 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 977
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 909 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 968
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 969 TCTAELIV 976
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 886 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 945
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 946 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 985
Score = 36.3 bits (80), Expect = 1.2
Identities = 23/103 (22%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTKGD-ALVRWFKDGSEIQFSNHIQLTIDGKKQKLKI 1165
P +LQ+ V +G K + +++ A + W +G ++ + I L+ +G + I
Sbjct: 176 PAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSI 235
Query: 1166 YDCDLDDAGEYSC----EVGNSKCTAILTVEEPSINFTLRLPE 1204
+D G Y C + G ++C+ +TV++ + + PE
Sbjct: 236 EKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE 278
Score = 33.9 bits (74), Expect = 6.4
Identities = 19/81 (23%), Positives = 33/81 (40%)
Query: 1587 GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIE 1646
G + L+ + PP +IW NG L+ K ++ + + I++ Y
Sbjct: 190 GKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCV 249
Query: 1647 ASNTAGTSSVEVTLKVYDKPS 1667
A N AG + + V D P+
Sbjct: 250 AKNDAGQAECSCQVTVDDAPA 270
>U41725-1|AAD09360.1| 1502|Homo sapiens PTPsigma-(brain) protein.
Length = 1502
Score = 93.5 bits (222), Expect = 7e-18
Identities = 106/530 (20%), Positives = 198/530 (37%), Gaps = 36/530 (6%)
Query: 1473 VIKETKIQS--PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD----GKKLKTAK 1526
V++E ++ S P ++ + E + C G P P++TW++D +
Sbjct: 124 VLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGR 183
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV 1586
Y+C+A N G +S + + + H++
Sbjct: 184 IKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEI 243
Query: 1587 --GDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
G +T V G P P V W + L + + + +V+ + ++K S ++ +
Sbjct: 244 MPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPV----GRNVLELTDVKDS-ANYHP 298
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
A ++ G + V P P P++ E + S+TI W D G + Y +
Sbjct: 299 CVAMSSLGVIEAVAQITVKSLPKAPGTPMV-TENTATSITITW----DSGNPDPVSYYVI 353
Query: 1705 KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTAL 1764
+++ + D Y I L+ N EY V A N +G + SE +V +T
Sbjct: 354 EYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG--QGPPSESVVTRTGE 411
Query: 1765 DVPSXXXXXXXXXXIDNESVYITW-FPSEKNG--GSPIIDYKVEIKQEGKKWKXXXXXXX 1821
P+ + ++ + W P E NG + Y +E + W+
Sbjct: 412 QAPARPPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDS 471
Query: 1822 XXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRS 1881
+ L + TY R+ A +G P + D I + P QP N + S
Sbjct: 472 LLTTVGSLLEDETYTVRVLAFTSVGDG-PLS--DPIQVKTQQGVPGQPMNLRAEARSETS 528
Query: 1882 VTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRIS 1941
+TL W+ P I Y + F+ +G ++ + +E++K E FR++
Sbjct: 529 ITLSWSPPRQES---IIKYELLFR--EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLA 583
Query: 1942 AENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPE 1991
A + G+ T + + T+ S +++M+ V+ SW P+
Sbjct: 584 ARSPQGLGAFTP-----VVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPD 628
Score = 91.1 bits (216), Expect = 4e-17
Identities = 144/659 (21%), Positives = 256/659 (38%), Gaps = 57/659 (8%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID-SKSA 1343
E PP+ + ++ G + + P+P W K + + D S A
Sbjct: 30 EEPPRFIKEPKDQIGVSGRVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGA 89
Query: 1344 SLTIKKVENT-DAGIYKLRLENNCGHADVEMNVTILDKPS-PPGKPNI--------LEID 1393
L I+ + D +Y+ +N+ G V +T+L + P G PNI +E
Sbjct: 90 VLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERT 149
Query: 1394 SSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWIS-VKNITKTQTSIQNLKTNSSYRF 1451
++ +C +GN I + ++ +D + +K + I++ + ++
Sbjct: 150 RTATMLC----AASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKY 205
Query: 1452 RAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQP 1511
A N + +S Y +V ++ P+ + P ++ +TC+ G P P
Sbjct: 206 ECVATNSAGVRYSSPANLYVRV---RRVAPRFSILPMSH-EIMPGGNVNITCVAVGSPMP 261
Query: 1512 KVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKP 1571
V W + + L T + + C+A + G +E + ++ P
Sbjct: 262 YVKWMQGAEDL-TPEDDMPVGRNVLELTDVKDSANYHPCVAMSSLGVIEAVAQITVKSLP 320
Query: 1572 VITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEN-DKEYNITTKEKTSVI 1630
+ + +T + P V +Y K ++ D Y I T+
Sbjct: 321 KAP-GTPMVTENTATS----ITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRY 375
Query: 1631 RIKELKRSHSSKYTIEASNTAGT---SSVEVTLKVYDKPSKPEGPVIMREISRESVTIEW 1687
I L + + + A N+ G S VT P++P V R +S ++ ++W
Sbjct: 376 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPARPPRNVQARMLSATTMIVQW 435
Query: 1688 KPPLDDGGL---ELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQ 1744
+ P++ GL Y +E P N W K +VD + T + L E+ Y RV+A
Sbjct: 436 EEPVEPNGLIRGYRVYYTMEPEHPVGN-WQK-HNVDDSLLT-TVGSLLEDETYTVRVLAF 492
Query: 1745 NPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKV 1804
VG + S+PI +KT VP + S+ ++W P + II Y++
Sbjct: 493 TSVG--DGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPPRQES---IIKYEL 546
Query: 1805 EIKQEGKKWKXXXXXXXXXAR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKT 1862
+ +EG + ++ L NT Y FR+ AR+ G +T + +T
Sbjct: 547 -LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGA-FTP---VVRQRT 601
Query: 1863 LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFK----TVKGKSWTKIVT 1917
L S P+NF V SV L W P+ N SP T Y I++ V G++ K++T
Sbjct: 602 LQSIS-PKNFKVKMIMKTSVLLSWEFPD-NYNSP-TPYKIQYNGLTLDVDGRTTKKLIT 657
Score = 83.4 bits (197), Expect = 8e-15
Identities = 72/264 (27%), Positives = 117/264 (44%), Gaps = 10/264 (3%)
Query: 717 GEASLPIVLKIK-TGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV 775
G L +VL + +EPP+ I+ K I G Q G+P+P +TW K K V
Sbjct: 14 GPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGRVASFVCQATGDPKPRVTWNKKGKKV 73
Query: 776 KALPTKS---DGDTHSITILKPKKV-KDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ ++ D ++ ++P + +DE VY A+NS G A +TV + +
Sbjct: 74 NSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSG 133
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELV 891
P Q V+ T ++ + NP P ITW+++ + PS + + + L
Sbjct: 134 FPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQ 193
Query: 892 ITNVDSEIDSGDYKCVASNSAG-KSSHGARVTIDVEKVT-FVKHLQKSYETEEGKTVILE 949
I + E D G Y+CVA+NSAG + S A + + V +V L S+E G V +
Sbjct: 194 IES-SEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNIT 252
Query: 950 CQT--SHTVSTKWYHNKKEISGMD 971
C S KW ++++ D
Sbjct: 253 CVAVGSPMPYVKWMQGAEDLTPED 276
Score = 77.0 bits (181), Expect = 7e-13
Identities = 98/410 (23%), Positives = 160/410 (39%), Gaps = 40/410 (9%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFSNHIQLTIDGKKQ 1161
E PP I ++Q G A+F + T GD R W K G ++ + D
Sbjct: 30 EEPPRFIKEPKDQIGVSGRVASFVCQAT-GDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
Query: 1162 K-LKIYDCDLD-DAGEYSCEVGNS--------KCTAILTVEEPSINFTLRL-PEFILVP- 1209
L+I D Y C NS K T + + PS + + P+ +V
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 1210 ANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
T L + ++TW+K ++ + I ++ L I E DQ +Y CV
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 208
Query: 1270 LLDA-----KSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVN 1324
++ S L V V P+ + I G +V + P P +W+
Sbjct: 209 ATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQG 268
Query: 1325 SKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLE-NNCGHADVEMNVTILDKPSP 1383
++ + P D ++ + D+ Y + ++ G + +T+ P
Sbjct: 269 AEDLT------PEDDMPVGRNVLELTDVKDSANYHPCVAMSSLGVIEAVAQITVKSLPKA 322
Query: 1384 PGKPNILEIDSSSINICWDEPENTGN-STIIYYVVEYQEIDTTEWISVK-NITKTQTSIQ 1441
PG P + E ++SI I WD +GN + YYV+EY+ +K +IT T+ SI
Sbjct: 323 PGTPMVTENTATSITITWD----SGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIG 378
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNI 1491
L NS Y AVN + SE+ V+ T Q+P +P +N+
Sbjct: 379 GLSPNSEYEIWVSAVNSIGQGPPSES-----VVTRTGEQAPA--RPPRNV 421
Score = 75.4 bits (177), Expect = 2e-12
Identities = 75/300 (25%), Positives = 127/300 (42%), Gaps = 24/300 (8%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F K+PK Q G C+ P+P + W KG+++ + IE D
Sbjct: 32 PPRFIKEPKDQIGVSGRVASFVCQATGDPKPRVTWNKKGKKV--NSQRFETIEFD-ESAG 88
Query: 693 SVLKITNVK-KFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP---PQVIEPLKSMIVRQ 748
+VL+I ++ E Y VA N GE ++ L + ++ P P + + +V +
Sbjct: 89 AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
Query: 749 GESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDEGVYT 804
+ + GNP P ITW K+ PV P+ S+G + ++ + D+G Y
Sbjct: 149 TRTATMLCAASGNPDPEITWFKDFLPVD--PSASNGRIKQLRSGALQIESSEETDQGKYE 206
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
A NS G+ +S P F + G + + +P+P +
Sbjct: 207 CVATNSAGVRYSSPANLY---VRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYV 263
Query: 865 TWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDY-KCVASNSAGKSSHGARVTI 923
W + E ++P + + G N+ L +T+V DS +Y CVA +S G A++T+
Sbjct: 264 KWMQGAEDLTPEDDMPV---GRNV-LELTDVK---DSANYHPCVAMSSLGVIEAVAQITV 316
Score = 74.5 bits (175), Expect = 4e-12
Identities = 81/338 (23%), Positives = 139/338 (41%), Gaps = 35/338 (10%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++ + + G F CQ G P+P++TW ++ + + + +D+ A L
Sbjct: 33 PRFIKEPKDQIGVSGRVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 570 IREV-FPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADI 628
I+ + P D + CVA+N+ G E+ V A L+ D
Sbjct: 93 IQPLRTPRDENVYECVAQNSVG------EITVHAKLT-----------------VLREDQ 129
Query: 629 LEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDM 688
L P P+ + V+ + C P+P+I W FK + +P + S +
Sbjct: 130 LPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITW-FK--DFLPVDP-SASNGRIK 185
Query: 689 HMYCSVLKITNVKKFQEGTYTVVAVNREG-EASLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ L+I + ++ +G Y VA N G S P L ++ P I P+ I+
Sbjct: 186 QLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIM- 244
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVY-TLK 806
G +V ++ VG+P P + W + + + T D +L+ VKD Y
Sbjct: 245 PGGNVNITCVAVGSPMPYVKWMQGAEDL----TPEDDMPVGRNVLELTDVKDSANYHPCV 300
Query: 807 AENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITV 844
A +S G+ E A ITV+ + P + N IT+
Sbjct: 301 AMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI 338
Score = 65.7 bits (153), Expect = 2e-09
Identities = 52/218 (23%), Positives = 102/218 (46%), Gaps = 12/218 (5%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P +V+E+T+ S+T+ W +S P++ Y+IE+K+ K + + + +
Sbjct: 320 PKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKS-KSQDGPYQIKEDITTTRY 375
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMT 1985
I + E +SA N++G P+ES R + A P+ P ++ RM+ + ++
Sbjct: 376 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA--PARPPRNVQARMLSATTMIV 433
Query: 1986 SWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVN-TLKFNIRDLSENHTYMIRIYAR 2044
W P G + GY + + K +V+ +L + L E+ TY +R+ A
Sbjct: 434 QWEEPVEPNGL-IRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAF 492
Query: 2045 NEIG---LSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
+G LS+P++ + + +PG+ + E +T +
Sbjct: 493 TSVGDGPLSDPIQV-KTQQGVPGQPMNLRAEARSETSI 529
>BC113458-1|AAI13459.1| 166|Homo sapiens MYLK protein protein.
Length = 166
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 36 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 95
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 96 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 152
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 59 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 116
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 117 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 156
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 33 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 92
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 93 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 151
Query: 924 D 924
+
Sbjct: 152 E 152
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 61 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 120
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 121 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 152
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 84 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 143
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 144 TCTAELIV 151
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 61 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 120
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 121 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 160
>BC113456-1|AAI13457.1| 167|Homo sapiens MYLK protein protein.
Length = 167
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 37 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 96
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 97 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 153
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 60 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 117
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 118 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 157
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 34 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 93
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 94 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 152
Query: 924 D 924
+
Sbjct: 153 E 153
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 62 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 121
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 122 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 153
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 85 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 144
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 145 TCTAELIV 152
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 62 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 121
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 122 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 161
>BC100762-1|AAI00763.2| 154|Homo sapiens myosin, light chain kinase
protein.
Length = 154
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 24 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 83
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 84 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 140
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 47 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 104
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 105 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 144
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 21 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 80
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 81 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 139
Query: 924 D 924
+
Sbjct: 140 E 140
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 49 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 108
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 109 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 140
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 72 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 131
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 132 TCTAELIV 139
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 49 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 108
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 109 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 148
>BC100761-1|AAI00762.2| 154|Homo sapiens myosin, light chain kinase
protein.
Length = 154
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 24 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 83
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 84 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 140
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 47 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 104
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 105 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 144
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 21 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 80
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 81 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 139
Query: 924 D 924
+
Sbjct: 140 E 140
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 49 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 108
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 109 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 140
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 72 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 131
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 132 TCTAELIV 139
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 49 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 108
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 109 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 148
>AF096775-1|AAD54019.1| 154|Homo sapiens kinase-related protein
isoform 2 protein.
Length = 154
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 24 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 83
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 84 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 140
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 47 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 104
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 105 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 144
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 21 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 80
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 81 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 139
Query: 924 D 924
+
Sbjct: 140 E 140
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 49 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 108
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 109 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 140
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 72 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 131
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 132 TCTAELIV 139
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 49 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 108
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 109 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 148
>AF096773-1|AAD54017.1| 154|Homo sapiens kinase-related protein
protein.
Length = 154
Score = 92.3 bits (219), Expect = 2e-17
Identities = 43/117 (36%), Positives = 70/117 (59%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 24 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 83
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 84 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 140
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 47 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 104
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 105 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 144
Score = 47.2 bits (107), Expect = 6e-04
Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 21 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 80
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 81 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 139
Query: 924 D 924
+
Sbjct: 140 E 140
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 49 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 108
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 109 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 140
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 72 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 131
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 132 TCTAELIV 139
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 49 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 108
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 109 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 148
>BC070170-1|AAH70170.1| 637|Homo sapiens TTN protein protein.
Length = 637
Score = 91.5 bits (217), Expect = 3e-17
Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA--LP----TKSDGDT 786
+ P +PL+S++V +G + A + G P P ++W ++ + + LP + SDG
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
+TI K + G Y+LKA N G A ++A + V+ T PP F+ R Q +TV++
Sbjct: 64 -KLTIPAVTKA-NSGRYSLKATNGSGQATSTAELLVKAETA----PPNFVQRLQSMTVRQ 117
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
++L RVT P P + +YR+ I S + +G+ L+I E DSG Y
Sbjct: 118 GSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPE-DSGTYSV 176
Query: 907 VASNSAGKSSHGARVTIDVEK 927
A+NS G+++ A + + E+
Sbjct: 177 NATNSVGRATSTAELLVQGEE 197
Score = 88.2 bits (209), Expect = 3e-16
Identities = 61/202 (30%), Positives = 99/202 (49%), Gaps = 9/202 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYC 692
PTF++ ++ V EGS E + P P+++W G+ I V I SD
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR--- 62
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L I V K G Y++ A N G+A+ L +K E PP ++ L+SM VRQG V
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-ETAPPNFVQRLQSMTVRQGSQV 121
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L +V G P P + + ++ +++ +GD +S+ I + +D G Y++ A N
Sbjct: 122 RLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYP-EDSGTYSVNATN 180
Query: 810 SEGIAETSAVITVEEPTEENAE 831
S G A ++A + V+ E A+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAK 202
Score = 76.2 bits (179), Expect = 1e-12
Identities = 64/231 (27%), Positives = 104/231 (45%), Gaps = 35/231 (15%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ--DFQMYYDDDN 564
+ AP F + L+ +GST FE + G+P P+++WFR +I S Q+ + D
Sbjct: 3 TQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
A L I V ++G ++ A N +G A+ST +E+ V
Sbjct: 63 -AKLTIPAVTKANSGRYSLKATNGSGQATST-------------AELLVKA--------- 99
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
E PP F ++ ++ V +GS + L+ R+ IP P + + G EI + ++
Sbjct: 100 -----ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQ 154
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP 735
E D++ L I GTY+V A N G A+ L ++ GE+E P
Sbjct: 155 EGDLYS----LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ-GEEEVP 200
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 1/96 (1%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
++ P FV++L+ GS V+ + +V G P P + ++R A I+ S DFQ+ + D +
Sbjct: 100 ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD-L 158
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+L+I E +PED+GT++ A N+ G A+ST EL+V+
Sbjct: 159 YSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 65.7 bits (153), Expect = 2e-09
Identities = 54/185 (29%), Positives = 83/185 (44%), Gaps = 9/185 (4%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNK-YDFEKRGHIRKL 1074
P F + LQ V E A E I+ +V W RDG++I KL
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1075 YIRNTSVHDEGEYSCILRDES----CTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEI 1128
I + + G YS + S TAE+ V PP + RLQ+ V +G++ ++
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 1129 ELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
+T +V++++DG+EIQ S Q++ +G L I + +D+G YS NS A
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 1188 ILTVE 1192
T E
Sbjct: 186 TSTAE 190
Score = 57.6 bits (133), Expect = 5e-07
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 7/197 (3%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------ATYENRX 1533
Q+PT +PL+++ G P P+V+W+RDG+ + T+ + + R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDEWLV 1592
Y A N G+ ++ + ++ + + ++ + G + +
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ GIP P V +Y++G ++++ ++ I+ + + I E S Y++ A+N+ G
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 1653 TSSVEVTLKVYDKPSKP 1669
++ L V + P
Sbjct: 184 RATSTAELLVQGEEEVP 200
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISD 1247
+T + P+ FT L +++ +T + +V+W++ VI T IS
Sbjct: 1 MTTQAPT--FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF 58
Query: 1248 VKKRT-LIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
R L I T+ + Y+ + A ST +L V+ PP V + +++G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
S V L V P P ++ + I+ + S + SL I + D+G Y +
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
N+ G A + + + P K + ++ I+
Sbjct: 179 TNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQIS 214
>BC058824-1|AAH58824.1| 558|Homo sapiens TTN protein protein.
Length = 558
Score = 91.5 bits (217), Expect = 3e-17
Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA--LP----TKSDGDT 786
+ P +PL+S++V +G + A + G P P ++W ++ + + LP + SDG
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
+TI K + G Y+LKA N G A ++A + V+ T PP F+ R Q +TV++
Sbjct: 64 -KLTIPAVTKA-NSGRYSLKATNGSGQATSTAELLVKAETA----PPNFVQRLQSMTVRQ 117
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
++L RVT P P + +YR+ I S + +G+ L+I E DSG Y
Sbjct: 118 GSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPE-DSGTYSV 176
Query: 907 VASNSAGKSSHGARVTIDVEK 927
A+NS G+++ A + + E+
Sbjct: 177 NATNSVGRATSTAELLVQGEE 197
Score = 88.2 bits (209), Expect = 3e-16
Identities = 61/202 (30%), Positives = 99/202 (49%), Gaps = 9/202 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYC 692
PTF++ ++ V EGS E + P P+++W G+ I V I SD
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR--- 62
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L I V K G Y++ A N G+A+ L +K E PP ++ L+SM VRQG V
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-ETAPPNFVQRLQSMTVRQGSQV 121
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L +V G P P + + ++ +++ +GD +S+ I + +D G Y++ A N
Sbjct: 122 RLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYP-EDSGTYSVNATN 180
Query: 810 SEGIAETSAVITVEEPTEENAE 831
S G A ++A + V+ E A+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAK 202
Score = 76.2 bits (179), Expect = 1e-12
Identities = 64/231 (27%), Positives = 104/231 (45%), Gaps = 35/231 (15%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ--DFQMYYDDDN 564
+ AP F + L+ +GST FE + G+P P+++WFR +I S Q+ + D
Sbjct: 3 TQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
A L I V ++G ++ A N +G A+ST +E+ V
Sbjct: 63 -AKLTIPAVTKANSGRYSLKATNGSGQATST-------------AELLVKA--------- 99
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
E PP F ++ ++ V +GS + L+ R+ IP P + + G EI + ++
Sbjct: 100 -----ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQ 154
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP 735
E D++ L I GTY+V A N G A+ L ++ GE+E P
Sbjct: 155 EGDLYS----LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ-GEEEVP 200
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 1/96 (1%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
++ P FV++L+ GS V+ + +V G P P + ++R A I+ S DFQ+ + D +
Sbjct: 100 ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD-L 158
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+L+I E +PED+GT++ A N+ G A+ST EL+V+
Sbjct: 159 YSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 65.7 bits (153), Expect = 2e-09
Identities = 54/185 (29%), Positives = 83/185 (44%), Gaps = 9/185 (4%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNK-YDFEKRGHIRKL 1074
P F + LQ V E A E I+ +V W RDG++I KL
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1075 YIRNTSVHDEGEYSCILRDES----CTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEI 1128
I + + G YS + S TAE+ V PP + RLQ+ V +G++ ++
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 1129 ELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
+T +V++++DG+EIQ S Q++ +G L I + +D+G YS NS A
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 1188 ILTVE 1192
T E
Sbjct: 186 TSTAE 190
Score = 57.6 bits (133), Expect = 5e-07
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 7/197 (3%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------ATYENRX 1533
Q+PT +PL+++ G P P+V+W+RDG+ + T+ + + R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDEWLV 1592
Y A N G+ ++ + ++ + + ++ + G + +
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ GIP P V +Y++G ++++ ++ I+ + + I E S Y++ A+N+ G
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 1653 TSSVEVTLKVYDKPSKP 1669
++ L V + P
Sbjct: 184 RATSTAELLVQGEEEVP 200
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISD 1247
+T + P+ FT L +++ +T + +V+W++ VI T IS
Sbjct: 1 MTTQAPT--FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF 58
Query: 1248 VKKRT-LIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
R L I T+ + Y+ + A ST +L V+ PP V + +++G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
S V L V P P ++ + I+ + S + SL I + D+G Y +
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
N+ G A + + + P K + ++ I+
Sbjct: 179 TNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQIS 214
>BC013396-1|AAH13396.1| 305|Homo sapiens TTN protein protein.
Length = 305
Score = 91.5 bits (217), Expect = 3e-17
Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 13/201 (6%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA--LP----TKSDGDT 786
+ P +PL+S++V +G + A + G P P ++W ++ + + LP + SDG
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 787 HSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKE 846
+TI K + G Y+LKA N G A ++A + V+ T PP F+ R Q +TV++
Sbjct: 64 -KLTIPAVTKA-NSGRYSLKATNGSGQATSTAELLVKAETA----PPNFVQRLQSMTVRQ 117
Query: 847 KGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKC 906
++L RVT P P + +YR+ I S + +G+ L+I E DSG Y
Sbjct: 118 GSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPE-DSGTYSV 176
Query: 907 VASNSAGKSSHGARVTIDVEK 927
A+NS G+++ A + + E+
Sbjct: 177 NATNSVGRATSTAELLVQGEE 197
Score = 88.2 bits (209), Expect = 3e-16
Identities = 61/202 (30%), Positives = 99/202 (49%), Gaps = 9/202 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYC 692
PTF++ ++ V EGS E + P P+++W G+ I V I SD
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR--- 62
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
+ L I V K G Y++ A N G+A+ L +K E PP ++ L+SM VRQG V
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-ETAPPNFVQRLQSMTVRQGSQV 121
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L +V G P P + + ++ +++ +GD +S+ I + +D G Y++ A N
Sbjct: 122 RLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYP-EDSGTYSVNATN 180
Query: 810 SEGIAETSAVITVEEPTEENAE 831
S G A ++A + V+ E A+
Sbjct: 181 SVGRATSTAELLVQGEEEVPAK 202
Score = 76.2 bits (179), Expect = 1e-12
Identities = 64/231 (27%), Positives = 104/231 (45%), Gaps = 35/231 (15%)
Query: 507 SMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQ--DFQMYYDDDN 564
+ AP F + L+ +GST FE + G+P P+++WFR +I S Q+ + D
Sbjct: 3 TQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
A L I V ++G ++ A N +G A+ST +E+ V
Sbjct: 63 -AKLTIPAVTKANSGRYSLKATNGSGQATST-------------AELLVKA--------- 99
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
E PP F ++ ++ V +GS + L+ R+ IP P + + G EI + ++
Sbjct: 100 -----ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQ 154
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPP 735
E D++ L I GTY+V A N G A+ L ++ GE+E P
Sbjct: 155 EGDLYS----LLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ-GEEEVP 200
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/96 (37%), Positives = 61/96 (63%), Gaps = 1/96 (1%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNV 565
++ P FV++L+ GS V+ + +V G P P + ++R A I+ S DFQ+ + D +
Sbjct: 100 ETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGD-L 158
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+L+I E +PED+GT++ A N+ G A+ST EL+V+
Sbjct: 159 YSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 65.7 bits (153), Expect = 2e-09
Identities = 54/185 (29%), Positives = 83/185 (44%), Gaps = 9/185 (4%)
Query: 1017 PEFIRKLQDFEVKEKDVAILEVEINS-ETADVVWERDGEIIKPKKNK-YDFEKRGHIRKL 1074
P F + LQ V E A E I+ +V W RDG++I KL
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1075 YIRNTSVHDEGEYSCILRDES----CTAEVTVVE--LPPEIITRLQNQKVNKGNKATFEI 1128
I + + G YS + S TAE+ V PP + RLQ+ V +G++ ++
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 1129 ELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTA 1187
+T +V++++DG+EIQ S Q++ +G L I + +D+G YS NS A
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 1188 ILTVE 1192
T E
Sbjct: 186 TSTAE 190
Score = 57.6 bits (133), Expect = 5e-07
Identities = 38/197 (19%), Positives = 84/197 (42%), Gaps = 7/197 (3%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK------ATYENRX 1533
Q+PT +PL+++ G P P+V+W+RDG+ + T+ + + R
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKH-KVGDEWLV 1592
Y A N G+ ++ + ++ + + ++ + G + +
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRL 123
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+ GIP P V +Y++G ++++ ++ I+ + + I E S Y++ A+N+ G
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 1653 TSSVEVTLKVYDKPSKP 1669
++ L V + P
Sbjct: 184 RATSTAELLVQGEEEVP 200
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 8/216 (3%)
Query: 1189 LTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE-DTEKFTLISD 1247
+T + P+ FT L +++ +T + +V+W++ VI T IS
Sbjct: 1 MTTQAPT--FTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISF 58
Query: 1248 VKKRT-LIIRKCTEDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRG 1302
R L I T+ + Y+ + A ST +L V+ PP V + +++G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 1303 SDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRL 1362
S V L V P P ++ + I+ + S + SL I + D+G Y +
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNA 178
Query: 1363 ENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSIN 1398
N+ G A + + + P K + ++ I+
Sbjct: 179 TNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQIS 214
>AC005338-1|AAC27825.1| 475|Homo sapiens PTPsigma, partial CDS
protein.
Length = 475
Score = 91.1 bits (216), Expect = 4e-17
Identities = 97/476 (20%), Positives = 174/476 (36%), Gaps = 30/476 (6%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD----GKKLKTAKATYENRXXXXX 1537
P ++ + E + C G P P++TW++D +
Sbjct: 9 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQI 68
Query: 1538 XXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV--GDEWLVTAV 1595
Y+C+A N G +S + + + H++ G +T V
Sbjct: 69 ESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCV 128
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSS 1655
G P P V W + L + + + +V+ + ++K S+ YT A ++ G
Sbjct: 129 AVGSPMPYVKWMQGAEDLTPEDDMPV----GRNVLELTDVK--DSANYTCVAMSSLGVIE 182
Query: 1656 VEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
+ V P P P++ E + S+TI W D G + Y + +++ +
Sbjct: 183 AVAQITVKSLPKAPGTPMV-TENTATSITITW----DSGNPDPVSYYVIEYKSKSQDGPY 237
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXX 1775
D Y I L+ N EY V A N +G + SE +V +T P+
Sbjct: 238 QIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG--QGPPSESVVTRTGEQAPASAPRNVQ 295
Query: 1776 XXXIDNESVYITW-FPSEKNG--GSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSIN 1832
+ ++ + W P E NG + Y +E + W+ + L +
Sbjct: 296 ARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED 355
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESN 1892
TY R+ A +G P + D I + P QP N + S+TL W+ P
Sbjct: 356 ETYTVRVLAFTSVGDG-PLS--DPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQE 412
Query: 1893 GGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGV 1948
I Y + F+ +G ++ + +E++K E FR++A + G+
Sbjct: 413 S---IIKYELLFR--EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGL 463
Score = 76.6 bits (180), Expect = 9e-13
Identities = 61/249 (24%), Positives = 102/249 (40%), Gaps = 17/249 (6%)
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDA-----KSTTKLK 1280
++TW+K ++ + I ++ L I E DQ +Y CV ++ S L
Sbjct: 39 EITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLY 98
Query: 1281 VEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V V P+ + I G +V + P P +W+ ++ + P D
Sbjct: 99 VRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLT------PEDDM 152
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINIC 1400
++ + D+ Y ++ G + +T+ P PG P + E ++SI I
Sbjct: 153 PVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITIT 212
Query: 1401 WDEPENTGN-STIIYYVVEYQEIDTTEWISVK-NITKTQTSIQNLKTNSSYRFRAYAVNE 1458
WD +GN + YYV+EY+ +K +IT T+ SI L NS Y AVN
Sbjct: 213 WD----SGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNS 268
Query: 1459 VDISDASET 1467
+ SE+
Sbjct: 269 IGQGPPSES 277
Score = 63.7 bits (148), Expect = 7e-09
Identities = 51/218 (23%), Positives = 101/218 (46%), Gaps = 12/218 (5%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P +V+E+T+ S+T+ W +S P++ Y+IE+K+ K + + + +
Sbjct: 193 PKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKS-KSQDGPYQIKEDITTTRY 248
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMT 1985
I + E +SA N++G P+ES R + A +P ++ RM+ + ++
Sbjct: 249 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRN--VQARMLSATTMIV 306
Query: 1986 SWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDV-NTLKFNIRDLSENHTYMIRIYAR 2044
W P G + GY + + K +V ++L + L E+ TY +R+ A
Sbjct: 307 QWEEPVEPNGL-IRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAF 365
Query: 2045 NEIG---LSEPLESDEPFKVIPGEGSHADEEPGEQTEV 2079
+G LS+P++ + + +PG+ + E +T +
Sbjct: 366 TSVGDGPLSDPIQV-KTQQGVPGQPMNLRAEARSETSI 402
Score = 60.1 bits (139), Expect = 9e-08
Identities = 54/212 (25%), Positives = 90/212 (42%), Gaps = 10/212 (4%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P P+ + V+ + C P+P+I W FK + +P + S + +
Sbjct: 9 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITW-FK--DFLPVDP-SASNGRIKQLRSG 64
Query: 694 VLKITNVKKFQEGTYTVVAVNREG-EASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L+I + ++ +G Y VA N G S P L ++ P I P+ I+ G +V
Sbjct: 65 ALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIM-PGGNV 123
Query: 753 ILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEG 812
++ VG+P P + W + + + T D +L+ VKD YT A +S G
Sbjct: 124 NITCVAVGSPMPYVKWMQGAEDL----TPEDDMPVGRNVLELTDVKDSANYTCVAMSSLG 179
Query: 813 IAETSAVITVEEPTEENAEPPLFINRFQEITV 844
+ E A ITV+ + P + N IT+
Sbjct: 180 VIEAVAQITVKSLPKAPGTPMVTENTATSITI 211
Score = 53.6 bits (123), Expect = 7e-06
Identities = 45/183 (24%), Positives = 78/183 (42%), Gaps = 16/183 (8%)
Query: 745 IVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI----LKPKKVKDE 800
+V + + + GNP P ITW K+ PV P+ S+G + ++ + D+
Sbjct: 19 VVERTRTATMLCAASGNPDPEITWFKDFLPVD--PSASNGRIKQLRSGALQIESSEETDQ 76
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
G Y A NS G+ +S P F + G + + +P
Sbjct: 77 GKYECVATNSAGVRYSSPANLY---VRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSP 133
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+P + W + E ++P + + G N+ L +T+V DS +Y CVA +S G A+
Sbjct: 134 MPYVKWMQGAEDLTPEDDMPV---GRNV-LELTDVK---DSANYTCVAMSSLGVIEAVAQ 186
Query: 921 VTI 923
+T+
Sbjct: 187 ITV 189
Score = 46.8 bits (106), Expect = 9e-04
Identities = 37/132 (28%), Positives = 62/132 (46%), Gaps = 5/132 (3%)
Query: 844 VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
V+ T ++ + NP P ITW+++ + PS + + + L I + + E D G
Sbjct: 20 VERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSE-ETDQGK 78
Query: 904 YKCVASNSAG-KSSHGARVTIDVEKVT-FVKHLQKSYETEEGKTVILECQT--SHTVSTK 959
Y+CVA+NSAG + S A + + V +V L S+E G V + C S K
Sbjct: 79 YECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK 138
Query: 960 WYHNKKEISGMD 971
W ++++ D
Sbjct: 139 WMQGAEDLTPED 150
Score = 43.2 bits (97), Expect = 0.010
Identities = 31/110 (28%), Positives = 51/110 (46%), Gaps = 12/110 (10%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FS P + + G ++ + C V P P + W+ E++ P E DM +
Sbjct: 104 VAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTP--------EDDMPVG 155
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEP--PQVIE 739
+VL++T+VK YT VA++ G + +K+ K P P V E
Sbjct: 156 RNVLELTDVK--DSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTE 203
Score = 37.1 bits (82), Expect = 0.69
Identities = 22/70 (31%), Positives = 28/70 (40%), Gaps = 1/70 (1%)
Query: 526 TVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVA 585
T C G P P+ITWF+ + PS L I D G + CVA
Sbjct: 25 TATMLCAASGNPDPEITWFKDFLPVDPSAS-NGRIKQLRSGALQIESSEETDQGKYECVA 83
Query: 586 KNAAGFASST 595
N+AG S+
Sbjct: 84 TNSAGVRYSS 93
Score = 34.7 bits (76), Expect = 3.7
Identities = 21/88 (23%), Positives = 36/88 (40%), Gaps = 7/88 (7%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G V C G P P + W + + P DD V V+ +D+ +TC
Sbjct: 120 GGNVNITCVAVGSPMPYVKWMQGAEDLTPE-------DDMPVGRNVLELTDVKDSANYTC 172
Query: 584 VAKNAAGFASSTTELIVEAPLSDHGSEM 611
VA ++ G + ++ V++ G+ M
Sbjct: 173 VAMSSLGVIEAVAQITVKSLPKAPGTPM 200
>X90870-1|CAA62378.1| 458|Homo sapiens myosin-light-chain kinase
protein.
Length = 458
Score = 90.2 bits (214), Expect = 7e-17
Identities = 41/116 (35%), Positives = 66/116 (56%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR 545
+KL + E E+ + P F + +R +GS +F+C++EGYP P++ WF+
Sbjct: 329 EKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFK 388
Query: 546 QTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 389 DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 444
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 351 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 408
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 409 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 448
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
L AE E +E + +E EE P F +++ V E + ++ P P
Sbjct: 326 LNAEKLE--SEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPE 383
Query: 864 ITWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A +
Sbjct: 384 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELI 442
Query: 923 ID 924
++
Sbjct: 443 VE 444
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 353 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 412
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 413 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 444
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 376 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 435
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 436 TCTAELIV 443
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 353 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 412
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 413 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 452
>BC107783-1|AAI07784.1| 227|Homo sapiens MYLK protein protein.
Length = 227
Score = 90.2 bits (214), Expect = 7e-17
Identities = 41/116 (35%), Positives = 66/116 (56%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR 545
+KL + E E+ + P F + +R +GS +F+C++EGYP P++ WF+
Sbjct: 98 EKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFK 157
Query: 546 QTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 158 DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 213
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 120 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 177
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 178 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 217
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
L AE E +E + +E EE P F +++ V E + ++ P P
Sbjct: 95 LNAEKLE--SEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPE 152
Query: 864 ITWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A +
Sbjct: 153 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELI 211
Query: 923 ID 924
++
Sbjct: 212 VE 213
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 122 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 181
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 182 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 213
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 145 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 204
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 205 TCTAELIV 212
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 122 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 181
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 182 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 221
>BC100763-1|AAI00764.2| 153|Homo sapiens myosin, light chain kinase
protein.
Length = 153
Score = 90.2 bits (214), Expect = 7e-17
Identities = 41/116 (35%), Positives = 66/116 (56%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR 545
+KL + E E+ + P F + +R +GS +F+C++EGYP P++ WF+
Sbjct: 24 EKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFK 83
Query: 546 QTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 84 DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 139
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 46 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 103
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 104 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 143
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
L AE E +E + +E EE P F +++ V E + ++ P P
Sbjct: 21 LNAEKLE--SEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPE 78
Query: 864 ITWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A +
Sbjct: 79 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELI 137
Query: 923 ID 924
++
Sbjct: 138 VE 139
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 48 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 107
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 108 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 139
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 71 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 130
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 131 TCTAELIV 138
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 48 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 107
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 108 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 147
>BC064420-1|AAH64420.2| 153|Homo sapiens myosin, light chain kinase
protein.
Length = 153
Score = 90.2 bits (214), Expect = 7e-17
Identities = 41/116 (35%), Positives = 66/116 (56%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR 545
+KL + E E+ + P F + +R +GS +F+C++EGYP P++ WF+
Sbjct: 24 EKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFK 83
Query: 546 QTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 84 DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 139
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 46 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 103
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 104 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 143
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
L AE E +E + +E EE P F +++ V E + ++ P P
Sbjct: 21 LNAEKLE--SEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPE 78
Query: 864 ITWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A +
Sbjct: 79 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELI 137
Query: 923 ID 924
++
Sbjct: 138 VE 139
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 48 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 107
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 108 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 139
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 71 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 130
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 131 TCTAELIV 138
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 48 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 107
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 108 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 147
>BC017811-1|AAH17811.1| 236|Homo sapiens MYLK protein protein.
Length = 236
Score = 90.2 bits (214), Expect = 7e-17
Identities = 41/116 (35%), Positives = 66/116 (56%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR 545
+KL + E E+ + P F + +R +GS +F+C++EGYP P++ WF+
Sbjct: 97 EKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFK 156
Query: 546 QTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 157 DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 212
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 119 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 176
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 177 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 216
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
L AE E +E + +E EE P F +++ V E + ++ P P
Sbjct: 94 LNAEKLE--SEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPE 151
Query: 864 ITWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A +
Sbjct: 152 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELI 210
Query: 923 ID 924
++
Sbjct: 211 VE 212
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 121 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 180
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 181 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 212
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 144 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 203
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 204 TCTAELIV 211
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 121 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 180
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 181 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 220
>AF096774-1|AAD54018.1| 153|Homo sapiens kinase-related protein
isoform 1 protein.
Length = 153
Score = 90.2 bits (214), Expect = 7e-17
Identities = 41/116 (35%), Positives = 66/116 (56%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR 545
+KL + E E+ + P F + +R +GS +F+C++EGYP P++ WF+
Sbjct: 24 EKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFK 83
Query: 546 QTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 84 DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 139
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 46 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 103
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 104 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 143
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
L AE E +E + +E EE P F +++ V E + ++ P P
Sbjct: 21 LNAEKLE--SEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPE 78
Query: 864 ITWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A +
Sbjct: 79 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELI 137
Query: 923 ID 924
++
Sbjct: 138 VE 139
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 48 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 107
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 108 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 139
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 71 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 130
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 131 TCTAELIV 138
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 48 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 107
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 108 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 147
>AF096771-2|AAD51381.1| 153|Homo sapiens kinase related protein
protein.
Length = 153
Score = 90.2 bits (214), Expect = 7e-17
Identities = 41/116 (35%), Positives = 66/116 (56%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR 545
+KL + E E+ + P F + +R +GS +F+C++EGYP P++ WF+
Sbjct: 24 EKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFK 83
Query: 546 QTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 84 DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 139
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 46 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 103
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 104 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 143
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
L AE E +E + +E EE P F +++ V E + ++ P P
Sbjct: 21 LNAEKLE--SEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPE 78
Query: 864 ITWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A +
Sbjct: 79 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELI 137
Query: 923 ID 924
++
Sbjct: 138 VE 139
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 48 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 107
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 108 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 139
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 71 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 130
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 131 TCTAELIV 138
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 48 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 107
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 108 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 147
>AF096771-1|AAD51380.1| 300|Homo sapiens smooth muscle/nonmuscle
myosin light chain kinase protein.
Length = 300
Score = 90.2 bits (214), Expect = 7e-17
Identities = 41/116 (35%), Positives = 66/116 (56%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR 545
+KL + E E+ + P F + +R +GS +F+C++EGYP P++ WF+
Sbjct: 171 EKLESEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFK 230
Query: 546 QTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 231 DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 286
Score = 49.6 bits (113), Expect = 1e-04
Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 193 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 250
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 251 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 290
Score = 44.8 bits (101), Expect = 0.003
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAE-PPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
L AE E +E + +E EE P F +++ V E + ++ P P
Sbjct: 168 LNAEKLE--SEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPE 225
Query: 864 ITWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVT 922
+ W+++++ I S ++D + N L+I++V + D Y C A NS G+++ A +
Sbjct: 226 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELI 284
Query: 923 ID 924
++
Sbjct: 285 VE 286
Score = 42.3 bits (95), Expect = 0.018
Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 195 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 254
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 255 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 286
Score = 40.7 bits (91), Expect = 0.056
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 218 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 277
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 278 TCTAELIV 285
Score = 39.1 bits (87), Expect = 0.17
Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 195 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 254
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 255 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 294
>AF040990-1|AAC39575.1| 1651|Homo sapiens roundabout 1 protein.
Length = 1651
Score = 90.2 bits (214), Expect = 7e-17
Identities = 78/327 (23%), Positives = 132/327 (40%), Gaps = 25/327 (7%)
Query: 605 SDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPD 664
SD G + V A++ P+F K+P V +C P P
Sbjct: 233 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 292
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIV 724
+ W K + +P + D H LKI V G+YT VA N G+A
Sbjct: 293 VRWR-KDDGELPKSRYEI---RDDH----TLKIRKVTAGDMGSYTCVAENMVGKAEASAT 344
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNN--------KPVK 776
L + +EPP + + +V G +V + GNP+P I W + +P +
Sbjct: 345 LTV----QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 400
Query: 777 ALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFI 836
+ S T +TI ++ D G Y + N G T A + V + + PP+
Sbjct: 401 SSSRFSVSQTGDLTITNVQR-SDVGYYICQTLNVAGSIITKAYLEVTDVIADR-PPPVIR 458
Query: 837 NRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVD 896
TV GT L T +PVP+I W ++ ++S ++ + + +++ +
Sbjct: 459 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 518
Query: 897 SEIDSGDYKCVASNSAGKSSHGARVTI 923
D+G Y C+AS +G+++ A + +
Sbjct: 519 ---DTGRYTCIASTPSGEATWSAYIEV 542
Score = 79.4 bits (187), Expect = 1e-13
Identities = 108/484 (22%), Positives = 179/484 (36%), Gaps = 44/484 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
E PP + P V +G L C+ P P I W GE + D++ + +
Sbjct: 64 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 123
Query: 690 M-YCSVLKITNVKKFQ--EGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMI 745
L+I + +K + EG Y VA N GEA S L++ + Q P ++
Sbjct: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ--NP-SDVM 180
Query: 746 VRQGESVILSAQVV-GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYT 804
V GE ++ Q G+P PTI+W K+ P+ + + I +K D G Y
Sbjct: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRK-SDAGKYV 239
Query: 805 LKAENSEGIAETS-AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPS 863
N G E+ A +TV E P F+ R + V + + +PVP+
Sbjct: 240 CVGTNMVGERESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 292
Query: 864 ITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ W +++ + S ++ I V D G Y CVA N GK+ A +T+
Sbjct: 293 VRWRKDDGELPKSRYEIRDDHTLKIRKVTAG-----DMGSYTCVAENMVGKAEASATLTV 347
Query: 924 DVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGM-------DHREII 976
VK + G+TV +C+ + + ++ +
Sbjct: 348 QEPPHFVVK--PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 405
Query: 977 QEGRXXXXXXXXXXXXDVGVIKC----IVKDQETSTMLVVKETI----PEFIRK--LQDF 1026
+ DVG C + T L V + I P IR+ +
Sbjct: 406 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 465
Query: 1027 EVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGE 1086
+ + V S ++W +DG ++ + ++ + G L IR + D G
Sbjct: 466 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG---VLQIRYAKLGDTGR 522
Query: 1087 YSCI 1090
Y+CI
Sbjct: 523 YTCI 526
Score = 77.4 bits (182), Expect = 5e-13
Identities = 108/462 (23%), Positives = 184/462 (39%), Gaps = 56/462 (12%)
Query: 1338 IDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEM-NVTILDKPSPPGKPNILEI--DS 1394
I + L I +DAG Y N G + E+ +T+L++PS +P+ L + D
Sbjct: 218 ITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD 277
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRA 1453
S+ C E G+ V +++ D S I T I+ + +
Sbjct: 278 SAEFKC----EARGDPVP---TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTC 330
Query: 1454 YAVNEVDISDASETTEYYKVIKETKIQSPT--VEKPLKNITTEPNEDIELTCIFGGVPQP 1511
A N V ++AS T +Q P V KP + + C G PQP
Sbjct: 331 VAENMVGKAEASATLT---------VQEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQP 380
Query: 1512 KVTWYRDGKK---------LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETS 1562
+ W R+G + +++ + Y C N G + T
Sbjct: 381 AIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK 440
Query: 1563 CVVG----IQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ I +P I + Q V ++++ V G P P ++W K+G L + ++
Sbjct: 441 AYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG-VLVSTQD 499
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD-----KPSKPEGPV 1673
I E V++I+ K + +YT AS +G ++ ++V + +P +P P
Sbjct: 500 SRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 558
Query: 1674 I---------MREISRESVTIEWKPPLDDGGLELTKYAIEK-HEPDNNRWIKVADVDRDV 1723
+ + ++SR +VT+ W+P L+ G T Y IE + W VA+ +
Sbjct: 559 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-TSYIIEAFSHASGSSWQTVAE-NVKT 616
Query: 1724 ETYCIQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTAL 1764
ET I+ L N Y+F V A N G S+ + S+P+ + L
Sbjct: 617 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVL 658
Score = 71.3 bits (167), Expect = 3e-11
Identities = 110/423 (26%), Positives = 167/423 (39%), Gaps = 64/423 (15%)
Query: 505 EQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQD----FQMYY 560
++ P VE G C+ EG P P I W++ ++ +D +M
Sbjct: 63 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 122
Query: 561 DDDNVATLVI---REVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXX 617
++ L I R+ P D G + CVA+N G A S + A L D +
Sbjct: 123 PSGSLFFLRIVHGRKSRP-DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ----NPS 177
Query: 618 XXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPD 677
++E PP +P + +GS + + D +G +++
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGS---------PLDDKDERITIRGGKLM-- 226
Query: 678 ENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV 737
I+ +SD Y V GT V RE E + VL+ + K P
Sbjct: 227 --ITYTRKSDAGKYVCV-----------GTNMV--GERESEVAELTVLERPSFVKRP--- 268
Query: 738 IEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKV 797
++ V +S + G+P PT+ W K++ LP KS + LK +KV
Sbjct: 269 ----SNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---GELP-KSRYEIRDDHTLKIRKV 320
Query: 798 K--DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVAR 855
D G YT AEN G AE SA +TV+ EPP F+ + ++ V T+
Sbjct: 321 TAGDMGSYTCVAENMVGKAEASATLTVQ-------EPPHFVVKPRDQVVALGRTVTFQCE 373
Query: 856 VTRNPVPSITWYR---NNEIIS--PSETITQNFDGENIELVITNVDSEIDSGDYKCVASN 910
T NP P+I W R N + S P ++ ++ + +L ITNV D G Y C N
Sbjct: 374 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGYYICQTLN 432
Query: 911 SAG 913
AG
Sbjct: 433 VAG 435
Score = 70.5 bits (165), Expect = 6e-11
Identities = 98/408 (24%), Positives = 157/408 (38%), Gaps = 39/408 (9%)
Query: 1006 TSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSE-TADVVWERDGEIIKPKKNKYD 1064
T + L ++ P + D V + + A L + T + W + GE ++ K+
Sbjct: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
Query: 1065 FEKR----GHIRKLYIRN--TSVHDEGEYSCILRDE-----SCTAEVTVVELPPEIITRL 1113
+ G + L I + S DEG Y C+ R+ S A + V L +
Sbjct: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
Query: 1114 QNQKVNKGNKATFEIELTKG--DALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLD 1171
+ V G A E + +G + + W KDGS + + ++TI G K L I
Sbjct: 177 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGK--LMITYTRKS 233
Query: 1172 DAGEYSCEVGN------SKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETL 1225
DAG+Y C N S+ + +E PS ++ P + V + A E + +
Sbjct: 234 DAGKYVCVGTNMVGERESEVAELTVLERPSF---VKRPSNLAVTVDDSAEFKCEARGDPV 290
Query: 1226 DVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-V 1284
++K ++ + D TL IRK T D YTCV + + + V
Sbjct: 291 PTVRWRKDDGELPKSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 347
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK--- 1341
+ PP V R+ + G VT + PQP W + P S+
Sbjct: 348 QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 407
Query: 1342 --SASLTIKKVENTDAGIYKLRLENNCG----HADVEMNVTILDKPSP 1383
+ LTI V+ +D G Y + N G A +E+ I D+P P
Sbjct: 408 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 455
Score = 70.5 bits (165), Expect = 6e-11
Identities = 71/274 (25%), Positives = 112/274 (40%), Gaps = 14/274 (5%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHM-Y 691
PP F KP+ Q V G + +C P+P I W +G + + S +
Sbjct: 350 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 409
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT--GEKEPPQVIEPLKSMIVRQG 749
L ITNV++ G Y +N G L++ ++ PP + + + V
Sbjct: 410 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 469
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ +LS G+P PTI W K+ V ++ + + ++ K+ D G YT A
Sbjct: 470 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 529
Query: 810 SEGIAETSAVITVEEPTEENAEP-PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYR 868
G A SA I V+E P P N K + V V+RN V +++W
Sbjct: 530 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPE-----VTDVSRNTV-TLSWQP 583
Query: 869 N-NEIISPSETITQNF---DGENIELVITNVDSE 898
N N +P+ I + F G + + V NV +E
Sbjct: 584 NLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE 617
Score = 68.9 bits (161), Expect = 2e-10
Identities = 122/538 (22%), Positives = 207/538 (38%), Gaps = 59/538 (10%)
Query: 731 EKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTH--- 787
E PP+++E +IV +GE L+ + G P PTI W K + V+ K D +H
Sbjct: 64 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET--DKDDPRSHRML 121
Query: 788 ----SITILK----PKKVKDEGVYTLKAENSEGIAET-SAVITVEEPTEENAEPPLFINR 838
S+ L+ K DEGVY A N G A + +A + V ++ + P +
Sbjct: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-- 179
Query: 839 FQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSE 898
+ V E ++ +P P+I+W ++ SP + + +L+IT +
Sbjct: 180 --MVAVGEPAVME-CQPPRGHPEPTISWKKDG---SPLDDKDERITIRGGKLMIT-YTRK 232
Query: 899 IDSGDYKCVASNSAG-KSSHGARVTIDVEKVTFVKHLQK-SYETEEGKTVILECQTSHTV 956
D+G Y CV +N G + S A +T+ +E+ +FVK + ++ E +
Sbjct: 233 SDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP 291
Query: 957 STKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQ----ETSTMLVV 1012
+ +W + E+ EI + D+G C+ ++ E S L V
Sbjct: 292 TVRWRKDDGELP-KSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 347
Query: 1013 KETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGE-----IIKPKKNKYDFE 1066
+E P F+ K +D V + E + W R+G +P ++ F
Sbjct: 348 QEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 406
Query: 1067 KRGHIRKLYIRNTSVHDEGEYSCILRD------ESCTAEVT--VVELPPEIITR-LQNQK 1117
L I N D G Y C + EVT + + PP +I + NQ
Sbjct: 407 V-SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 465
Query: 1118 VNKGNKATFEIELTKGDA-LVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY 1176
V T + W KDG + S + L+I L D G Y
Sbjct: 466 VAVDGTFVLSCVATGSPVPTILWRKDG--VLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 523
Query: 1177 SC----EVGNSKCTAILTVEEPSINFTLRLP-EFILVPANTDAYLTVEIPDETLDVTW 1229
+C G + +A + V+E + P + L+P+ ++ T+ ++W
Sbjct: 524 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 581
Score = 58.4 bits (135), Expect = 3e-07
Identities = 109/502 (21%), Positives = 192/502 (38%), Gaps = 58/502 (11%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFS-----NHIQLTID 1157
+ PP I+ + V+KG AT + + + W+K G ++ +H L
Sbjct: 65 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
Query: 1158 GKKQKLKIYDC--DLDDAGEYSCEVGNSKCTAI---LTVEEPSINFTLRL-PEFILVPAN 1211
G L+I D G Y C N A+ ++E + R P ++V
Sbjct: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184
Query: 1212 TDAYLTVEIPDETLD--VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCV 1269
A + + P + ++W K S ++D ++ I K L+I + D +Y CV
Sbjct: 185 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK---LMITYTRKSDAGKYVCV 241
Query: 1270 LLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAF--------PQPNDEW 1321
+ + EV E + ER +KR S++ + VD A P P W
Sbjct: 242 --GTNMVGERESEVAE----LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 295
Query: 1322 IVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKP 1381
+ + K ++ +L I+KV D G Y EN G A+ +T+ + P
Sbjct: 296 RKDDGELPKSRYEIRD----DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
Query: 1382 SPPGKPNILEIDSSSINICWDEPENTGN-STIIYY--------VVEYQEIDTTEWISVKN 1432
KP ++ + + + + E TGN I++ + YQ ++ SV
Sbjct: 352 HFVVKPRD-QVVALGRTVTF-QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 409
Query: 1433 I-TKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV--EKPLK 1489
T T++Q +++ Y Y ++++ + T Y +V + P V + P+
Sbjct: 410 TGDLTITNVQ--RSDVGY----YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV- 462
Query: 1490 NITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXXXXXXXXXX 1547
N T + L+C+ G P P + W +DG + T + +
Sbjct: 463 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 522
Query: 1548 YKCIAFNDHGEVETSCVVGIQQ 1569
Y CIA GE S + +Q+
Sbjct: 523 YTCIASTPSGEATWSAYIEVQE 544
Score = 48.8 bits (111), Expect = 2e-04
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSVHE 1924
PS P V++ + +VTL W +P N G+ T+YIIE F G SW + V
Sbjct: 561 PSAPSKPEVTDVSRNTVTLSW-QPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTET 618
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE 1953
I+ +K +F + A N G+S P++
Sbjct: 619 SAIKGLKPNAIYLFLVRAANAYGISDPSQ 647
Score = 48.0 bits (109), Expect = 4e-04
Identities = 60/238 (25%), Positives = 90/238 (37%), Gaps = 38/238 (15%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA-----IIKPSQDFQMYYDDDN 564
P FV K R + G TV F+C+ G P+P I W R+ + +P Q +
Sbjct: 351 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS-SSRFSVSQ 409
Query: 565 VATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXX 624
L I V D G + C N AG +I +A L E+T
Sbjct: 410 TGDLTITNVQRSDVGYYICQTLNVAG------SIITKAYL-----EVTDV---------- 448
Query: 625 XADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAI 684
I + PP + P Q V +L C P P I W G + ++ +
Sbjct: 449 ---IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 505
Query: 685 ESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKT--GEKEPPQVIEP 740
E+ VL+I K G YT +A GEA+ ++++ +PP+ +P
Sbjct: 506 EN------GVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDP 557
Score = 46.8 bits (106), Expect = 9e-04
Identities = 31/97 (31%), Positives = 46/97 (47%), Gaps = 4/97 (4%)
Query: 1965 VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNI-AIRDVTKTMWMEVGKVDVNT 2023
+PS P+ P E+ V N V SW P + GA Y I A + + W V + +V T
Sbjct: 560 IPSAPSKP-EVTDVSRNTVTLSW-QPNLNSGATPTSYIIEAFSHASGSSWQTVAE-NVKT 616
Query: 2024 LKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
I+ L N Y+ + A N G+S+P + +P K
Sbjct: 617 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 653
Score = 41.9 bits (94), Expect = 0.024
Identities = 40/174 (22%), Positives = 64/174 (36%), Gaps = 13/174 (7%)
Query: 1507 GVPQPKVTWYRDGKKL--KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCV 1564
G P+P ++W +DG L K + T Y C+ N GE E+
Sbjct: 196 GHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVA 254
Query: 1565 -VGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITT 1623
+ + ++P ++ V D G P P V W K+ +L + Y I
Sbjct: 255 ELTVLERPSFVKRPSNLAV--TVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEI-- 309
Query: 1624 KEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPS---KPEGPVI 1674
++I+++ YT A N G + TL V + P KP V+
Sbjct: 310 -RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 362
>BC065720-1|AAH65720.1| 445|Homo sapiens MYBPC1 protein protein.
Length = 445
Score = 89.8 bits (213), Expect = 9e-17
Identities = 52/157 (33%), Positives = 83/157 (52%), Gaps = 3/157 (1%)
Query: 1038 VEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCT 1097
VE+ +V W ++G+ I+P KY FE +G R L+I N + D+ EY DE C+
Sbjct: 248 VELADPKLEVKWYKNGQEIRPS-TKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCS 306
Query: 1098 AEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEI--QFSNHIQLT 1155
E+ V E P + +L++ G + E E+++ DA V+WFK+G EI + ++
Sbjct: 307 TELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIR 366
Query: 1156 IDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
++GKK L I DA EYS + +A L+V+
Sbjct: 367 VEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVD 403
Score = 83.0 bits (196), Expect = 1e-14
Identities = 55/193 (28%), Positives = 94/193 (48%), Gaps = 5/193 (2%)
Query: 1117 KVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEY 1176
+V+KG + F +EL V+W+K+G EI+ S G ++ L I +C + D EY
Sbjct: 237 QVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEY 296
Query: 1177 SCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK-KSV 1235
G+ KC+ L V EP I T +L E L E+ ++ +V W+K + +
Sbjct: 297 YVTAGDEKCSTELFVREPPIMVTKQL-EDTTAYCGERVELECEVSEDDANVKWFKNGEEI 355
Query: 1236 IEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYE 1294
I + ++ + + KK LII T+ D EY+ + +S+ KL V++ P KI+
Sbjct: 356 IPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLK--PLKILTPL 413
Query: 1295 REYRIKRGSDVTL 1307
+ + G ++ L
Sbjct: 414 TDQTVNLGKEICL 426
Score = 68.1 bits (159), Expect = 3e-10
Identities = 52/209 (24%), Positives = 91/209 (43%), Gaps = 2/209 (0%)
Query: 926 EKVTFVKHLQKSYETEEGKTVILECQTSHT-VSTKWYHNKKEISGMDHREIIQEGRXXXX 984
+ F K L +Y+ ++G V + + + KWY N +EI +G
Sbjct: 224 KSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRIL 283
Query: 985 XXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSET 1044
D D++ ST L V+E ++L+D + LE E++ +
Sbjct: 284 FINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDD 343
Query: 1045 ADVVWERDGEIIKP-KKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVV 1103
A+V W ++GE I P K++Y G L I + D EYS + +A+++V
Sbjct: 344 ANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVD 403
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTK 1132
P +I+T L +Q VN G + + E+++
Sbjct: 404 LKPLKILTPLTDQTVNLGKEICLKCEISE 432
Score = 40.3 bits (90), Expect = 0.074
Identities = 29/116 (25%), Positives = 49/116 (42%), Gaps = 14/116 (12%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIV--PDENISVAIESDMHMYCSVLKITNVKKFQE 705
G + LEC V+ + ++ W GEEI+ P + +E H +L I K
Sbjct: 330 GERVELECE-VSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKH----ILIIEGATKADA 384
Query: 706 GTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGN 761
Y+V+ + A L + LK P +++ PL V G+ + L ++ N
Sbjct: 385 AEYSVMTTGGQSSAKLSVDLK-------PLKILTPLTDQTVNLGKEICLKCEISEN 433
Score = 39.5 bits (88), Expect = 0.13
Identities = 32/139 (23%), Positives = 66/139 (47%), Gaps = 10/139 (7%)
Query: 831 EPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSITWYRNNEII--SPSETITQNFDGEN 887
EPP+ + + E T G ++L V+ + ++ W++N E I P +G+
Sbjct: 313 EPPIMVTKQLEDTTAYCGERVELECEVSEDDA-NVKWFKNGEEIIPGPKSRYRIRVEGKK 371
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVI 947
L+I ++ D+ +Y + + G+SS A++++D++ + + L GK +
Sbjct: 372 HILIIEGA-TKADAAEYSVMTTG--GQSS--AKLSVDLKPLKILTPLTDQ-TVNLGKEIC 425
Query: 948 LECQTSHTVSTKWYHNKKE 966
L+C+ S + K KK+
Sbjct: 426 LKCEISENIPKKKKKKKKK 444
Score = 38.7 bits (86), Expect = 0.23
Identities = 47/201 (23%), Positives = 75/201 (37%), Gaps = 10/201 (4%)
Query: 844 VKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGD 903
V + G ++ V + +P + WY+N + I PS G L I N DS
Sbjct: 238 VDKGGRVRFVVELA-DPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEY 296
Query: 904 YKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSH-TVSTKWYH 962
Y +AG + + + K L+ + G+ V LEC+ S + KW+
Sbjct: 297 YV-----TAGDEKCSTELFVREPPIMVTKQLEDT-TAYCGERVELECEVSEDDANVKWFK 350
Query: 963 NKKE-ISGMDHREIIQ-EGRXXXXXXXXXXXXDVGVIKCIVKDQETSTMLVVKETIPEFI 1020
N +E I G R I+ EG+ D + ++S L V + +
Sbjct: 351 NGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKIL 410
Query: 1021 RKLQDFEVKEKDVAILEVEIN 1041
L D V L+ EI+
Sbjct: 411 TPLTDQTVNLGKEICLKCEIS 431
>AF069604-1|AAD15924.1| 560|Homo sapiens myosin light chain kinase
isoform 4 protein.
Length = 560
Score = 89.4 bits (212), Expect = 1e-16
Identities = 42/117 (35%), Positives = 69/117 (58%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P F + +R +GS +F+C++EGYP P++ WF
Sbjct: 430 EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWF 489
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T E IVE
Sbjct: 490 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAEHIVE 546
Score = 79.8 bits (188), Expect = 1e-13
Identities = 41/139 (29%), Positives = 65/139 (46%), Gaps = 1/139 (0%)
Query: 1332 KHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPP-GKPNIL 1390
+H K + LTI G Y L +EN G ++N+T++DKP PP G P
Sbjct: 2 EHIKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCAS 61
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+I SSS+ + W G S + Y +E + W + T ++Q+L + Y+
Sbjct: 62 DIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYK 121
Query: 1451 FRAYAVNEVDISDASETTE 1469
FR A+N S+ S+ +E
Sbjct: 122 FRVRAINVYGTSEPSQESE 140
Score = 69.3 bits (162), Expect = 1e-10
Identities = 44/137 (32%), Positives = 64/137 (46%), Gaps = 3/137 (2%)
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISR 1680
+ E S + I ++ H YT+ N G+ +V L V DKP P G +I
Sbjct: 6 VENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRS 65
Query: 1681 ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFR 1740
S+T+ W DGG + Y+IE + N W ++A ++ +Q L + EY FR
Sbjct: 66 SSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRS--TSFNVQDLLPDHEYKFR 123
Query: 1741 VIAQNPVGFSE-ALESE 1756
V A N G SE + ESE
Sbjct: 124 VRAINVYGTSEPSQESE 140
Score = 57.6 bits (133), Expect = 5e-07
Identities = 59/282 (20%), Positives = 117/282 (41%), Gaps = 14/282 (4%)
Query: 1714 IKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXX 1773
IKV + + + + E+C + ++ +N +G +A V T +D P
Sbjct: 4 IKVENSENGSKLTILAARQEHCG-CYTLLVENKLGSRQAQ-----VNLTVVDKPDPPAGT 57
Query: 1774 XXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK-WKXXXXXXXXXARIQKLSIN 1832
I + S+ ++W+ S +GGS + Y +EI K WK +Q L +
Sbjct: 58 PCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPD 117
Query: 1833 TTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPR-NFVVSESTSRSVTLKWTEPES 1891
Y+FR+ A N GTS P + T+G+ P +P+ + + + +
Sbjct: 118 HEYKFRVRAINVYGTSEPSQESELTTVGE---KPEEPKMKWRCQTDDEKEPEVDYRTVTI 174
Query: 1892 NGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHE-HCIENIKEKDEIIFRISAENTVGVSL 1950
N ++++ + + G + +I+ + E CI+ +++ E + I + V + L
Sbjct: 175 NTEQKVSDF-YDIEERLGSLFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDL 233
Query: 1951 PTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEW 1992
E+ + + K T L R+ + + +GTPE+
Sbjct: 234 KPEN-IMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEF 274
Score = 55.2 bits (127), Expect = 2e-06
Identities = 29/92 (31%), Positives = 43/92 (46%), Gaps = 2/92 (2%)
Query: 1966 PSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK 2025
P PP + S+ + SW +DGG+ + Y+I I D W E+ +
Sbjct: 51 PDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATC--RSTS 108
Query: 2026 FNIRDLSENHTYMIRIYARNEIGLSEPLESDE 2057
FN++DL +H Y R+ A N G SEP + E
Sbjct: 109 FNVQDLLPDHEYKFRVRAINVYGTSEPSQESE 140
Score = 47.2 bits (107), Expect = 6e-04
Identities = 34/105 (32%), Positives = 55/105 (52%), Gaps = 6/105 (5%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P FSK + V EGS +C++ P+P++ W FK ++ + E+ I+ D
Sbjct: 453 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVW-FKDDQSI-RESRHFQIDYDEDGN 510
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLP---IVLKIKTGEKE 733
CS++ I++V + YT AVN GEA+ IV ++ GE E
Sbjct: 511 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAEHIVETMEEGEGE 554
Score = 45.6 bits (103), Expect = 0.002
Identities = 27/113 (23%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P F +++ V E + ++ P P +
Sbjct: 427 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEV 486
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSS 916
W+++++ I S ++D + N L+I++V + D Y C A NS G+++
Sbjct: 487 VWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEAT 538
Score = 40.7 bits (91), Expect = 0.056
Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P +++ +V +G+ A F+ ++ D V WFKD I+ S H Q+ D L
Sbjct: 455 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 514
Query: 1165 IYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
I D DD +Y+C+ NS A T E
Sbjct: 515 ISDVCGDDDAKYTCKAVNSLGEATCTAE 542
Score = 39.9 bits (89), Expect = 0.098
Identities = 18/61 (29%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W+K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 478 IEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 537
Query: 1655 S 1655
+
Sbjct: 538 T 538
Score = 37.1 bits (82), Expect = 0.69
Identities = 25/100 (25%), Positives = 43/100 (43%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 455 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLI 514
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A VE E E
Sbjct: 515 ISDVCGDDDAKYTCKAVNSLGEATCTAEHIVETMEEGEGE 554
>AB209412-1|BAD92649.1| 1130|Homo sapiens neogenin homolog 1 variant
protein.
Length = 1130
Score = 89.4 bits (212), Expect = 1e-16
Identities = 100/397 (25%), Positives = 164/397 (41%), Gaps = 23/397 (5%)
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDDG-GLELTKYAIEKHEPDNNRWIKVADVDRDVE 1724
PS P V+ +S + + W+ P D G LT E ++ +++
Sbjct: 135 PSAPRD-VVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 193
Query: 1725 TYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVP-SXXXXXXXXXXIDNES 1783
IQ L Y+FRV+AQN G E+ S P+ ++T +V S
Sbjct: 194 V-TIQNLMPATVYIFRVMAQNKHGSGES--SAPLRVETQPEVQLPGPAPNLRAYAASPTS 250
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
+ +TW + +G I +YK+ ++G + I L T Y FR+ A N
Sbjct: 251 ITVTW-ETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYN 309
Query: 1844 EIGTSLPYTSDDKITIGKTLT--PPSQPRNFVVSESTSRSVTLKWTEP-ESNGGSPITNY 1900
+ G P S + + +TL+ P + P+N + S+S+ + W P + IT Y
Sbjct: 310 KHG---PGVSTPDVAV-RTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGY 365
Query: 1901 IIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLE 1960
I ++ KS V G+ IE + E FR++A G T+ S
Sbjct: 366 KIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETF 425
Query: 1961 K----HATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV 2016
+ VP P++ L +R + ++IV+ SW PE + + GY AI + +
Sbjct: 426 ESDLDETRVPEVPSS-LHVRPLVTSIVV-SWTPPE-NQNIVVRGY--AIGYGIGSPHAQT 480
Query: 2017 GKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPL 2053
KVD + I +L + Y+I + A N +G PL
Sbjct: 481 IKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPL 517
Score = 84.6 bits (200), Expect = 3e-15
Identities = 83/358 (23%), Positives = 143/358 (39%), Gaps = 23/358 (6%)
Query: 1643 YTIEASNTAGTSSVEVTLKVYDKPS-KPEGPVI-MREI--SRESVTIEWKPPLDDGGLEL 1698
+ + A N G+ L+V +P + GP +R S S+T+ W+ P+ G E+
Sbjct: 207 FRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNG-EI 265
Query: 1699 TKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
Y + E + K DVD +Y I L + EY FRV+A N G + + +
Sbjct: 266 QNYKLYYMEKGTD---KEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHG--PGVSTPDV 320
Query: 1759 VIKTALDVPSXXXXXXXXXXIDNESVYITWF-PSEKNGGSPIIDYKVEIKQEGKK---WK 1814
++T DVPS +++S+ I W P+ I YK+ ++ +K +
Sbjct: 321 AVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTE 380
Query: 1815 XXXXXXXXXARIQKLSINTTYQFRIYAR--NEIGTSLPYTSDDKITIGKTLT-PPSQPRN 1871
I+ L T Y FR+ A N G + + S + T P P +
Sbjct: 381 TLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSS 440
Query: 1872 FVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIK 1931
V + S+ + WT PE N + Y I + G + + V + IEN+
Sbjct: 441 LHVRPLVT-SIVVSWTPPE-NQNIVVRGYAIGYGI--GSPHAQTIKVDYKQRYYTIENLD 496
Query: 1932 EKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIR--MVGSNIVMTSW 1987
+ + A N VG +P +V P+P P+ ++ ++ + + +W
Sbjct: 497 PSSHYVITLKAFNNVGEGIPLYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITW 554
Score = 54.8 bits (126), Expect = 3e-06
Identities = 127/614 (20%), Positives = 214/614 (34%), Gaps = 48/614 (7%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKT---- 1436
PS P + + I + W P + + + Y V Y T E I+ + + T
Sbjct: 135 PSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFY----TKEGIARERVENTSHPG 190
Query: 1437 --QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTE 1494
Q +IQNL + Y FR A N+ + E++ +V + ++Q P L+
Sbjct: 191 EMQVTIQNLMPATVYIFRVMAQNK---HGSGESSAPLRVETQPEVQLPGPAPNLRAYAAS 247
Query: 1495 PNEDIEL--TCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIA 1552
P T + G Y K + + ++ +A
Sbjct: 248 PTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVA 307
Query: 1553 FNDHGE-VETSCVV--GIQQKPVITISNE--DIKQKHKVGDEWL--VTAVIEGIPPPEVI 1605
+N HG V T V + P N +++ + W A G I
Sbjct: 308 YNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKI 367
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS------SVEVT 1659
Y+ ++ + E ++ + + +I + L R + + A GT S E
Sbjct: 368 RYRKASRKSDVTETLVSGTQLSQLI--EGLDRGTEYNFRVAALTINGTGPATDWLSAETF 425
Query: 1660 LKVYDKPSKPEGPVIMREISR-ESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVAD 1718
D+ PE P + S+ + W PP ++ + + YAI + +
Sbjct: 426 ESDLDETRVPEVPSSLHVRPLVTSIVVSWTPP-ENQNIVVRGYAIGYGIGSPHA--QTIK 482
Query: 1719 VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEAL-ESEPIVIKTALD-VPSXXXXXXXX 1776
VD Y I+ L+ + Y+ + A N VG L ES T D P
Sbjct: 483 VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTVPDPTPMMPPVGVQA 542
Query: 1777 XXIDNESVYITWFPSEKNGGSPIID---YKVEIKQE---GKKWKXXXXXXXXXARIQKLS 1830
+ ++++ ITW + I D Y V K K+K + L
Sbjct: 543 SILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYL-VTGLK 601
Query: 1831 INTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPE 1890
NT Y+F + +S + T T P + V E +++ + W +P
Sbjct: 602 PNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNW-QPP 660
Query: 1891 SNGGSPITNYIIEFKT---VKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVG 1947
S IT YII + T + W I V G+ H I+ + F+I A N+ G
Sbjct: 661 SEANGKITGYIIYYSTDVNAEIHDWV-IEPVVGNRLTHQIQELTLDTPYYFKIQARNSKG 719
Query: 1948 VSLPTESQSVRLEK 1961
+ +E+ R K
Sbjct: 720 MGPMSEAVQFRTPK 733
Score = 54.4 bits (125), Expect = 4e-06
Identities = 52/204 (25%), Positives = 83/204 (40%), Gaps = 9/204 (4%)
Query: 1847 TSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKT 1906
TSL + D + T PS PR+ V S ++R + L W P S+ Y + F T
Sbjct: 116 TSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSV-FYT 174
Query: 1907 VKGKSWTKIV-TVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATV 1965
+G + ++ T + I+N+ IFR+ A+N G S +R+E V
Sbjct: 175 KEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSG--ESSAPLRVETQPEV 232
Query: 1966 PSPPTAP-LEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTL 2024
P AP L + +W TP G + Y + + + VDV++
Sbjct: 233 QLPGPAPNLRAYAASPTSITVTWETPV-SGNGEIQNYKLYYMEKGTDKEQD---VDVSSH 288
Query: 2025 KFNIRDLSENHTYMIRIYARNEIG 2048
+ I L + Y R+ A N+ G
Sbjct: 289 SYTINGLKKYTEYSFRVVAYNKHG 312
Score = 52.0 bits (119), Expect = 2e-05
Identities = 40/195 (20%), Positives = 71/195 (36%), Gaps = 7/195 (3%)
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
A++ P F K+P Y E DI+ EC + P P + W+ G+ ++P + + E
Sbjct: 9 AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKE 68
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
+ L++ + K EG Y +A N G A L I + P + +
Sbjct: 69 HN-------LQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHDVAIPTLPPTSLTSA 121
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+ + + PR + + + +K D H + EG+
Sbjct: 122 TTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARE 181
Query: 806 KAENSEGIAETSAVI 820
+ EN+ E I
Sbjct: 182 RVENTSHPGEMQVTI 196
Score = 46.8 bits (106), Expect = 9e-04
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 5/104 (4%)
Query: 821 TVEEPTEENAEP-PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETI 879
T+E E + P F+ + I E I VT P P++ W +N +++ PS+
Sbjct: 4 TIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYF 63
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ N++ V+ V S D G Y+C+A N G + GA++ I
Sbjct: 64 -KIVKEHNLQ-VLGLVKS--DEGFYQCIAENDVGNAQAGAQLII 103
Score = 46.8 bits (106), Expect = 9e-04
Identities = 23/91 (25%), Positives = 46/91 (50%), Gaps = 4/91 (4%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P F+++ + + + FEC+V G P P + W + ++ PS F++ + + L
Sbjct: 17 PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN----LQ 72
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ + D G + C+A+N G A + +LI+
Sbjct: 73 VLGLVKSDEGFYQCIAENDVGNAQAGAQLII 103
Score = 44.0 bits (99), Expect = 0.006
Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 1/90 (1%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKP 794
P+ ++ ++ + ++ +V G P PT+ W KN V H++ +L
Sbjct: 17 PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGL 76
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEE 824
K DEG Y AEN G A+ A + + E
Sbjct: 77 VK-SDEGFYQCIAENDVGNAQAGAQLIILE 105
>AB040929-1|BAA96020.1| 920|Homo sapiens KIAA1496 protein protein.
Length = 920
Score = 89.4 bits (212), Expect = 1e-16
Identities = 106/465 (22%), Positives = 194/465 (41%), Gaps = 35/465 (7%)
Query: 645 VDEGSDILLECRLVAIP-EPDIAWLFKG-EEIVPDENISVAIESDMHMYCSVLKITNVKK 702
V EG ++L C E AW+F V +++ + H+Y S ++ ++V
Sbjct: 26 VREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGN 85
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQGESVILSAQVVG 760
+ ++V R + P+VL+ GE EP ++ +++ +G +V L +G
Sbjct: 86 YTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALG 145
Query: 761 NPRPTITWCKNNKPVKALPTKSDGDTHSIT-ILK-PK-KVKDEGVYTLKAENSEGIAETS 817
NP P I W +++ LP S + +L+ P + +D G Y AENS G
Sbjct: 146 NPIPQINWRRSD----GLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVAR 201
Query: 818 AVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSE 877
+T P ++ +++ + + ++ R + P PS W +N +
Sbjct: 202 GRLTY-------YAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAAL---- 250
Query: 878 TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKH-LQK 936
+ + EN L I+N+ S DSG ++C+A N G A + + F K+ ++K
Sbjct: 251 VLEERTQIENGALTISNL-SVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKK 309
Query: 937 SYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGV 996
+ + G V L+C+ + K ++S +H E I D G
Sbjct: 310 LVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEH-ERISLLNDGGLKIANVTKADAGT 368
Query: 997 IKCIVKDQ-----ETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV--W 1049
C+ ++Q T+ ++V + T D V E + +V+ + D++ W
Sbjct: 369 YTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQ-HDPLLDIIFTW 427
Query: 1050 ERDGEIIKPKKNKYDFEKRGHIRK--LYIRNTSVHDEGEYSCILR 1092
+G + KK+ FEK G L IRN + G+Y C+++
Sbjct: 428 YFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQ 472
Score = 86.2 bits (204), Expect = 1e-15
Identities = 75/328 (22%), Positives = 143/328 (43%), Gaps = 27/328 (8%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P+ +GS + LEC + P P I W + + + + + + VL+I N
Sbjct: 126 PETLPAAKGSTVKLECFALGNPIPQINWR-------RSDGLPFSSKIKLRKFSGVLEIPN 178
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVV 759
++ G+Y +A N G+ V + + P ++ +K + + +S+ +
Sbjct: 179 FQQEDAGSYECIAENSRGKN----VARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRAS 234
Query: 760 GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
G P+P+ W KN + L ++ + ++TI V D G++ AEN G+ +SA
Sbjct: 235 GKPKPSYRWLKNGAAL-VLEERTQIENGALTI-SNLSVTDSGMFQCIAENKHGLVYSSAE 292
Query: 820 ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETI 879
+ V + ++ P+ + + V+ + L + +P +W + + + E I
Sbjct: 293 LKVVASAPDFSKNPM----KKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERI 348
Query: 880 TQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
+ DG L I NV ++ D+G Y C+A N GK++ + V + T + + +
Sbjct: 349 SLLNDG---GLKIANV-TKADAGTYTCMAENQFGKANGTTHLV--VTEPTRITLAPSNMD 402
Query: 940 TEEGKTVILECQTSH----TVSTKWYHN 963
G++VIL CQ H + WY N
Sbjct: 403 VSVGESVILPCQVQHDPLLDIIFTWYFN 430
Score = 79.8 bits (188), Expect = 1e-13
Identities = 166/789 (21%), Positives = 282/789 (35%), Gaps = 61/789 (7%)
Query: 1253 LIIRKCTEDDQCEYTCVL---------LDAKSTTKLKVEVV--EFPPKI-VDYEREYRIK 1300
L I K D YTCV+ L + + L+ + V E+ PKI V +
Sbjct: 73 LYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAA 132
Query: 1301 RGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKL 1360
+GS V L P P W + + +K + S L I + DAG Y+
Sbjct: 133 KGSTVKLECFALGNPIPQINWRRSDGLPFS---SKIKLRKFSGVLEIPNFQQEDAGSYEC 189
Query: 1361 RLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY-YVVEY 1419
EN+ G +T KP +EI ++ W E +G Y ++
Sbjct: 190 IAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVED-SLYW-ECRASGKPKPSYRWLKNG 247
Query: 1420 QEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI 1479
+ E ++N T I NL S F+ A N+ + +S KV+
Sbjct: 248 AALVLEERTQIENGALT---ISNLSVTDSGMFQCIAENKHGLVYSSAEL---KVVASAPD 301
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR-DGKKLKTAKATYENRXXXXXX 1538
S K L + + + L C P+ +W + D + + + N
Sbjct: 302 FSKNPMKKL--VQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIA 359
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITI--SNEDIKQKHKVGDEWLVTAVI 1596
Y C+A N G+ + + + + IT+ SN D+ VG+ ++ +
Sbjct: 360 NVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVS----VGESVILPCQV 415
Query: 1597 EGIPPPEVI--WYKNGNKLENDKEYNITTK---EKTSVIRIKELKRSHSSKYTIEASNTA 1651
+ P ++I WY NG + K+ + K + + I+ ++ HS KY
Sbjct: 416 QHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGV 475
Query: 1652 GTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNN 1711
+ S L V P PE V + EI+ + + WK D+ + Y+I+ P +
Sbjct: 476 DSVSSAADLIVRGSPGPPEN-VKVDEITDTTAQLSWKEGKDNHS-PVISYSIQARTPFSV 533
Query: 1712 RWIKVADV----DRDVETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPIVIKTALDV 1766
W V V D T + +LN EY FRV+A N +G E +L SE ++T V
Sbjct: 534 GWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEK--VRTEEAV 591
Query: 1767 PSXXXXXXXXXXIDNESVYITW--FPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXX 1823
P + ITW P E G Y V + G W
Sbjct: 592 PEVPPSEVNGGGGSRSELVITWDPVPEELQNGEG-FGYVVAFRPLGVTTWIQTVVTSPDT 650
Query: 1824 ARI----QKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTS 1879
R + + + Y+ ++ N G P++ + + P P + +S
Sbjct: 651 PRYVFRNESIVPYSPYEVKVGVYNNKGEG-PFSPVTTVFSAEE-EPTVAPSQVSANSLSS 708
Query: 1880 RSVTLKW-TEPESNGGSPITNYIIEFKTVKGKSWTKI-VTVGGSVHEHCIENIKEKDEII 1937
+ + W T P + Y + + GK + + V G+ + +K
Sbjct: 709 SEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYY 768
Query: 1938 FRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAP 1997
+ A N+ G S +V + T PS P + + +++ + +
Sbjct: 769 TAVRAYNSAGAG--PFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESE 826
Query: 1998 LLGYNIAIR 2006
+ GY + R
Sbjct: 827 VTGYKVFYR 835
Score = 77.8 bits (183), Expect = 4e-13
Identities = 122/556 (21%), Positives = 209/556 (37%), Gaps = 55/556 (9%)
Query: 1499 IELTCIFGGVPQPKVTWYR-DGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHG 1557
++L C G P P++ W R DG + + Y+CIA N G
Sbjct: 137 VKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRG 196
Query: 1558 EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDK 1617
+ + KP +D++ + W A G P P W KNG L ++
Sbjct: 197 KNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRA--SGKPKPSYRWLKNGAALVLEE 254
Query: 1618 EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY----DKPSKPEGPV 1673
T+ + + I L + S + A N G LKV D P +
Sbjct: 255 R----TQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKL 310
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTK---YAIEKHEPD---NNRWIKVADVDR-DVETY 1726
+ ++ V+++ KP L K ++++HE N+ +K+A+V + D TY
Sbjct: 311 VQVQVG-SLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTY 369
Query: 1727 CIQKLNE--NCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESV 1784
N+ ++ P + A + + + ++ +P I
Sbjct: 370 TCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDII----- 424
Query: 1785 YITWFPSEKNGGSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNE 1844
TW+ NG + D+K ++G ++ I+ + + + ++ +
Sbjct: 425 -FTWY---FNGA--LADFK----KDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQT- 473
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEF 1904
G ++ D I G P P N V E T + L W E + N SP+ +Y I+
Sbjct: 474 -GVDSVSSAADLIVRGS----PGPPENVKVDEITDTTAQLSWKEGKDNH-SPVISYSIQA 527
Query: 1905 KTVKGKSWTKIVTV----GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPT-ESQSVRL 1959
+T W + TV G H + + E FR+ A N +G P+ S+ VR
Sbjct: 528 RTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRT 587
Query: 1960 EKHATVPSPPTAPLEIRMVG---SNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV 2016
E+ VP P P E+ G S +V+T PE GY +A R + T W++
Sbjct: 588 EE--AVPEVP--PSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQT 643
Query: 2017 GKVDVNTLKFNIRDLS 2032
+T ++ R+ S
Sbjct: 644 VVTSPDTPRYVFRNES 659
Score = 76.6 bits (180), Expect = 9e-13
Identities = 92/398 (23%), Positives = 164/398 (41%), Gaps = 34/398 (8%)
Query: 802 VYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNP 860
V T N+ + + ++ + EP + + +F E KG T+KL NP
Sbjct: 89 VVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEV-QFPETLPAAKGSTVKLECFALGNP 147
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
+P I W R++ + S+ + F G L I N E D+G Y+C+A NS GK+ R
Sbjct: 148 IPQINWRRSDGLPFSSKIKLRKFSG---VLEIPNFQQE-DAGSYECIAENSRGKNVARGR 203
Query: 921 VTIDVEKVTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGMDHREIIQE 978
+T K +V+ L K E ++ EC+ S S +W N + ++ R I+
Sbjct: 204 LTY-YAKPHWVQ-LIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALV-LEERTQIEN 260
Query: 979 GRXXXXXXXXXXXXDVGVIKCIVKDQE----TSTMLVVKETIPEFIRKLQDFEVKEKDVA 1034
G D G+ +CI +++ +S L V + P+F + V+ + +
Sbjct: 261 G---ALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGS 317
Query: 1035 ILEVEIN---SETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCIL 1091
++ ++ S A W++ G++ + + G ++ I N + D G Y+C+
Sbjct: 318 LVSLDCKPRASPRALSSWKK-GDVSVQEHERISLLNDGGLK---IANVTKADAGTYTCMA 373
Query: 1092 RDESCTAEVT---VVELPPEIITRLQNQKVNKGNKATFEIELTKG---DALVRWFKDGSE 1145
++ A T VV P I N V+ G ++ D + W+ +G+
Sbjct: 374 ENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGAL 433
Query: 1146 IQF---SNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEV 1180
F +H + L I + L +G+Y C V
Sbjct: 434 ADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMV 471
Score = 60.1 bits (139), Expect = 9e-08
Identities = 164/826 (19%), Positives = 303/826 (36%), Gaps = 92/826 (11%)
Query: 930 FVKHLQKSYETEEGKTVILECQT---SHTVSTKWYHNK-KEISGMDHREIIQEGRXXXXX 985
F ++ + EG+ V+L C S +S W N+ D R + +
Sbjct: 16 FKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQ-ETGHLY 74
Query: 986 XXXXXXXDVGVIKCIVKDQETS-------TMLVVKE--TIPEFIRKLQ-DFE-----VKE 1030
DVG C+V T+ T LV++ + E+ K++ F K
Sbjct: 75 ISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKG 134
Query: 1031 KDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCI 1090
V + + + + W R + P +K K + L I N D G Y CI
Sbjct: 135 STVKLECFALGNPIPQINWRRSDGL--PFSSKIKLRKFSGV--LEIPNFQQEDAGSYECI 190
Query: 1091 L---RDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEI 1146
R ++ P + +++ ++ + +E + K RW K+G+ +
Sbjct: 191 AENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAAL 250
Query: 1147 QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSK----CTAILTVEEPSINFTLRL 1202
Q+ + L I + + D+G + C N +A L V + +F+ +
Sbjct: 251 VLEERTQI----ENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFS-KN 305
Query: 1203 PEFILVPANTDAYLTVEIPDETLD---VTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCT 1259
P LV + ++++ +W K +++ E+ +L++D L I T
Sbjct: 306 PMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLND---GGLKIANVT 362
Query: 1260 EDDQCEYTCVLLD----AKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFP 1315
+ D YTC+ + A TT L VV P +I + G V L Q P
Sbjct: 363 KADAGTYTCMAENQFGKANGTTHL---VVTEPTRITLAPSNMDVSVGESVILPCQVQHDP 419
Query: 1316 QPND--EWIVNSKII---KKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHAD 1370
+ W N + K H + S S L I+ ++ +G Y ++
Sbjct: 420 LLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVS 479
Query: 1371 VEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISV 1430
++ + P PP + EI ++ + W E ++ +S +I Y ++ + + W +V
Sbjct: 480 SAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKD-NHSPVISYSIQARTPFSVGWQTV 538
Query: 1431 KNIT-----KTQT-SIQNLKTNSSYRFRAYAVNEVDISDAS------ETTEYYKVIKETK 1478
+ KT T ++ L Y FR A N++ + S T E + ++
Sbjct: 539 TTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSE 598
Query: 1479 IQSPTVEKPLKNITTEP-NEDIELTCIFGGV----PQPKVTWYRDGKKLKTAKATYENRX 1533
+ + IT +P E+++ FG V P TW + + T+ T R
Sbjct: 599 VNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWI---QTVVTSPDT--PRY 653
Query: 1534 XXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGI---QQKPVITISNEDIKQKHKVGDEW 1590
K +N+ GE S V + +++P + S E
Sbjct: 654 VFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEV 713
Query: 1591 LVTAVIEGIPPPEVIWYK-----NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTI 1645
+ + ++ Y+ G K E+ + + E ++ R++ LK + + +
Sbjct: 714 SWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSA--RLRGLKSNLAYYTAV 771
Query: 1646 EASNTAGTSSVEVTLKVYDK---PSKPEGPVIMREISRESVTIEWK 1688
A N+AG T+ V K PS+P G V+ + V + W+
Sbjct: 772 RAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTK-VLLNWE 816
Score = 54.0 bits (124), Expect = 6e-06
Identities = 51/142 (35%), Positives = 70/142 (49%), Gaps = 15/142 (10%)
Query: 634 PTFSKKP--KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
P FSK P K V GS + L+C+ A P +W KG+ V E+ +++ +D
Sbjct: 300 PDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWK-KGDVSV-QEHERISLLND---- 353
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
LKI NV K GTYT +A N+ G+A+ L + EP ++ +M V GES
Sbjct: 354 -GGLKIANVTKADAGTYTCMAENQFGKANGTTHLVV----TEPTRITLAPSNMDVSVGES 408
Query: 752 VILSAQVVGNPRPTI--TWCKN 771
VIL QV +P I TW N
Sbjct: 409 VILPCQVQHDPLLDIIFTWYFN 430
Score = 47.6 bits (108), Expect = 5e-04
Identities = 26/80 (32%), Positives = 39/80 (48%), Gaps = 4/80 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GS V +C+ PR +W + ++ + + D L I V DAGT+TC
Sbjct: 316 GSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGG----LKIANVTKADAGTYTC 371
Query: 584 VAKNAAGFASSTTELIVEAP 603
+A+N G A+ TT L+V P
Sbjct: 372 MAENQFGKANGTTHLVVTEP 391
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/97 (27%), Positives = 46/97 (47%), Gaps = 5/97 (5%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P +V+ ++ ++ +EC+ G P+P W + A + + Q+ +N A L
Sbjct: 210 PHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQI----ENGA-LT 264
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSD 606
I + D+G F C+A+N G S+ EL V A D
Sbjct: 265 ISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPD 301
Score = 40.7 bits (91), Expect = 0.056
Identities = 24/67 (35%), Positives = 33/67 (49%), Gaps = 4/67 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
GSTV+ EC G P PQI W R + S+ + L I EDAG++ C
Sbjct: 134 GSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFS----GVLEIPNFQQEDAGSYEC 189
Query: 584 VAKNAAG 590
+A+N+ G
Sbjct: 190 IAENSRG 196
>X16841-1|CAA34739.1| 761|Homo sapiens protein ( Human mRNA for a
nontransmembrane isoform of N-CAM from skeletal muscle.
).
Length = 761
Score = 89.0 bits (211), Expect = 2e-16
Identities = 93/398 (23%), Positives = 166/398 (41%), Gaps = 36/398 (9%)
Query: 593 SSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDIL 652
SS+T I A + D G V ++ F P Q EG D +
Sbjct: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVA 712
+ C +V+ P I W KG +++ +++ + S+ + L+I +KK EGTY
Sbjct: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-----NYLQIRGIKKTDEGTYRCEG 191
Query: 713 -VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKN 771
+ GE + + ++ Q + + + G+SV L G P PT++W K+
Sbjct: 192 RILARGEINFKDI-QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
Query: 772 NKPVKALPTKS----DGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
+ ++ D+ +TI K K DE Y AEN G E A I + +
Sbjct: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDK-NDEAEYICIAENKAG--EQDATIHL----K 303
Query: 828 ENAEPPL-FINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGE 886
A+P + ++ + ++E+ + L + +P+PSITW + IS E + DG
Sbjct: 304 VFAKPKITYVENQTAMELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEE---KTLDGH 358
Query: 887 NIELVITNVDS-------EIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE 939
+ V S D+G+Y C ASN+ G+ S + ++V+ ++ Y
Sbjct: 359 MVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS--MYLEVQYAPKLQGPVAVY- 415
Query: 940 TEEGKTVILECQ--TSHTVSTKWYHNKKEISGMDHREI 975
T EG V + C+ + + W+ + + + ++ I
Sbjct: 416 TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 453
Score = 85.4 bits (202), Expect = 2e-15
Identities = 74/299 (24%), Positives = 126/299 (42%), Gaps = 25/299 (8%)
Query: 628 ILEGIPPTFSKKPKA--QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
++ +PPT + + G + L C PEP ++W GE+I +E+ I
Sbjct: 206 VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF 265
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI 745
SD S L I V K E Y +A N+ GE I LK+ P++
Sbjct: 266 SDDS---SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA----KPKITYVENQTA 318
Query: 746 VRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGD----TH---SITILKPKKVK 798
+ E V L+ + G+P P+ITW + + + + DG +H S LK +
Sbjct: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
D G Y A N+ I + S + +E + P+ + + E + + V
Sbjct: 379 DAGEYICTASNT--IGQDSQSMYLEVQYAPKLQGPVAVYTW------EGNQVNITCEVFA 430
Query: 859 NPVPSITWYRNNEIISPSE-TITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P +I+W+R+ +++ S + + ++ + + DSE D G+Y C A N G+ S
Sbjct: 431 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
Score = 79.8 bits (188), Expect = 1e-13
Identities = 100/452 (22%), Positives = 184/452 (40%), Gaps = 46/452 (10%)
Query: 1101 TVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTI---D 1157
T V L +I+ V + ++ D + WF E N ++++ D
Sbjct: 16 TAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWND 75
Query: 1158 GKKQKLKIYDCDLDDAGEYSCEV---GNSKCTAILTVEEPSINFTLRLPEFILVPANTDA 1214
L IY+ ++DDAG Y C V S+ A + V+ P DA
Sbjct: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
Query: 1215 YLTVEIPDETLDVTWYKKKS---VIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTC--- 1268
+ ++ +K K +++ +F ++S+ L IR + D+ Y C
Sbjct: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGR 192
Query: 1269 VLLDAKSTTKLKVEVVEFPPKIVDYER--EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSK 1326
+L + K +V PP I + G VTL+ D + FP+P W + +
Sbjct: 193 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252
Query: 1327 IIKKCKHTKPSIDSKSAS-LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
I++ + + I S +S LTIKKV+ D Y EN G D +++ + KP
Sbjct: 253 QIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY 312
Query: 1386 KPN--ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQ- 1441
N +E++ C E +G+ I + W S +NI+ + ++
Sbjct: 313 VENQTAMELEEQVTLTC----EASGD-----------PIPSITWRTSTRNISSEEKTLDG 357
Query: 1442 NLKTNSSYRFRAYAVNEVDISDASE--TTEYYKVIKET-----KIQ-SPTVEKPLKNITT 1493
++ S R + + + +DA E T + +++ ++Q +P ++ P+ T
Sbjct: 358 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW 417
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTA 1525
E N+ + +TC P ++W+RDG+ L ++
Sbjct: 418 EGNQ-VNITCEVFAYPSATISWFRDGQLLPSS 448
Score = 73.7 bits (173), Expect = 6e-12
Identities = 112/536 (20%), Positives = 218/536 (40%), Gaps = 51/536 (9%)
Query: 1025 DFEVKEKDVAILEVEINSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRK-LYIRNTSVH 1082
+ V E + +V +++ D+ W +GE + P + + L I N ++
Sbjct: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
Query: 1083 DEGEYSCILRDESCT-AEVTV-VELPPEIITRLQN--QKVNKGNKATFEIELTKG-DALV 1137
D G Y C++ E + +E TV V++ +++ + Q+ +G A ++ +
Sbjct: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTI 149
Query: 1138 RWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVG-------NSKCTAILT 1190
W G ++ ++ + L+I D G Y CE N K ++
Sbjct: 150 IWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIV 208
Query: 1191 VEEPSI-------NFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIE---DTE 1240
P+I N T L + + + + + + P+ T+ +W K IE D E
Sbjct: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGF-----PEPTM--SWTKDGEQIEQEEDDE 261
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP-PKIVDYEREYRI 1299
K+ D + T I+K ++D+ EY C+ + + + F PKI E + +
Sbjct: 262 KYIFSDDSSQLT--IKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
Query: 1300 KRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCK-----HTKPSIDSKSASLTIKKVENTD 1354
+ VTL + P P+ W +++ I + H ++ +SLT+K ++ TD
Sbjct: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
Query: 1355 AGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
AG Y N G M + + P G + + + +NI E ++TI +
Sbjct: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITC-EVFAYPSATISW 438
Query: 1415 YVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVI 1474
+ + Q + ++ + ++K S + +S F Y V+ E+ E+ V
Sbjct: 439 F-RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN-RIGQESLEFILVQ 496
Query: 1475 KETKIQSPTVE--KPLKNITTEPNEDIELTCIFGGVP--QPKVTWYRDGKKLKTAK 1526
+T SP+++ +P + ++ E T GGVP + K W G+++ +K
Sbjct: 497 ADTP-SSPSIDQVEPYSSTAQVQFDEPEAT---GGVPILKYKAEWRAVGEEVWHSK 548
Score = 73.7 bits (173), Expect = 6e-12
Identities = 110/556 (19%), Positives = 208/556 (37%), Gaps = 50/556 (8%)
Query: 1226 DVTWYKK--KSVIEDTEKFTLI-SDVKKRTLIIRKCTEDDQCEYTCVLL-DAKSTTKLKV 1281
D++W+ + + + ++ +++ +D TL I DD Y CV+ + S ++ V
Sbjct: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
Query: 1282 EVVEFPPKIV-DYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS 1340
V F + + + G D ++ D + P W + + K + + S
Sbjct: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
Query: 1341 KSASLTIKKVENTDAGIYK----LRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSS- 1395
+ L I+ ++ TD G Y+ + D+++ V + P+ + NI+ ++
Sbjct: 171 NNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV--PPTIQARQNIVNATANL 227
Query: 1396 --SINICWDE---PENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
S+ + D PE T + T +E QE D ++I + +Q +I+ + N
Sbjct: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIE-QEEDDEKYIFSDD--SSQLTIKKVDKNDEAE 284
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
+ A N+ DA+ + + K T +++ T E E + LTC G P
Sbjct: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTA--------MELEEQVTLTCEASGDPI 336
Query: 1511 PKVTWYRDGKKLKTAKATYENR---------XXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
P +TW + + + + T + Y C A N G+
Sbjct: 337 PSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQ 396
Query: 1562 SCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNI 1621
S + +Q P + + G++ +T + P + W+++G L + NI
Sbjct: 397 SMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 453
Query: 1622 T--TKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREIS 1679
S + + + Y A N G S+E L D PS P + E
Sbjct: 454 KIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPY 511
Query: 1680 RESVTIEWKPPLDDGGLELTKYAIE----KHEPDNNRWIKVADVDRDVETYCIQKLNENC 1735
+ +++ P GG+ + KY E E +++W + + I L
Sbjct: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME-GIVTIVGLKPET 570
Query: 1736 EYMFRVIAQNPVGFSE 1751
Y R+ A N G E
Sbjct: 571 TYAVRLAALNGKGLGE 586
Score = 54.4 bits (125), Expect = 4e-06
Identities = 25/79 (31%), Positives = 41/79 (51%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G +V C EG+P P ++W + I+ +D + Y D+ + L I++V D + C
Sbjct: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N AG +T L V A
Sbjct: 288 IAENKAGEQDATIHLKVFA 306
Score = 48.0 bits (109), Expect = 4e-04
Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P A Y EG+ + + C + A P I+W F+ +++P N S I+ S L++T
Sbjct: 411 PVAVYTWEGNQVNITCEVFAYPSATISW-FRDGQLLPSSNYS-NIKIYNTPSASYLEVTP 468
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQV--IEPLKS 743
+ G Y AVNR G+ SL +L ++ P + +EP S
Sbjct: 469 DSENDFGNYNCTAVNRIGQESLEFIL-VQADTPSSPSIDQVEPYSS 513
Score = 41.1 bits (92), Expect = 0.042
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 4/85 (4%)
Query: 520 HTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQ--MYYDDDNVATLVIREVFPED 577
+T +G+ V C+V YP I+WFR ++ PS ++ Y+ + + L + D
Sbjct: 415 YTWEGNQVNITCEVFAYPSATISWFRDGQLL-PSSNYSNIKIYNTPSASYLEVTPDSEND 473
Query: 578 AGTFTCVAKNAAGFASSTTELIVEA 602
G + C A N G S ++V+A
Sbjct: 474 FGNYNCTAVNRIG-QESLEFILVQA 497
Score = 40.7 bits (91), Expect = 0.056
Identities = 33/131 (25%), Positives = 53/131 (40%), Gaps = 3/131 (2%)
Query: 524 GSTVQFECQVEGYPRPQ-ITWFRQTAI-IKPSQD-FQMYYDDDNVATLVIREVFPEDAGT 580
G + F CQV G + + I+WF + P+Q + ++DD+ +TL I +DAG
Sbjct: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
Query: 581 FTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKP 640
+ CV G S T + + T D++ +PPT K
Sbjct: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Query: 641 KAQYVDEGSDI 651
K + V D+
Sbjct: 154 KGRDVILKKDV 164
Score = 36.7 bits (81), Expect = 0.91
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 4/79 (5%)
Query: 527 VQFECQVEGYPRPQITWFRQTAIIKPSQ---DFQMYYDDD-NVATLVIREVFPEDAGTFT 582
V C+ G P P ITW T I + D M V++L ++ + DAG +
Sbjct: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
Query: 583 CVAKNAAGFASSTTELIVE 601
C A N G S + L V+
Sbjct: 385 CTASNTIGQDSQSMYLEVQ 403
Score = 34.3 bits (75), Expect = 4.9
Identities = 43/181 (23%), Positives = 74/181 (40%), Gaps = 7/181 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSW-TKIVTVGGSVHE 1924
PS P V E S + +++ EPE+ GG PI Y E++ V + W +K + E
Sbjct: 500 PSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 558
Query: 1925 HCIENIKEKDEIIF--RISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNI 1982
+ + K E + R++A N G+ + + + + P PP + V +
Sbjct: 559 GIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP-VHSPPPPASASSSTPVPLSP 617
Query: 1983 VMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
T+W P P G A + + M + + VN +K + H Y++R
Sbjct: 618 PDTTWPLPALATTEPAKGEPSAPK-LEGQMGEDGNSIKVNLIKQDDGGSPIRH-YLVRYR 675
Query: 2043 A 2043
A
Sbjct: 676 A 676
>BC005376-1|AAH05376.1| 498|Homo sapiens myotilin protein.
Length = 498
Score = 88.6 bits (210), Expect = 2e-16
Identities = 55/206 (26%), Positives = 94/206 (45%), Gaps = 8/206 (3%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F + P+ +DEG ++ ++ +P PD++W G + D+ + I S+ ++
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD-LHKMIVSEKGLHS 307
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGES 751
+ ++ V+ G Y VA NR GEA+ + L + E K P I +S V +G+S
Sbjct: 308 LIFEV--VRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDS 365
Query: 752 VILSAQVVGNPRPTITWCKNNKPVK----ALPTKSDGDTHSITILKPKKVKDEGVYTLKA 807
V L Q+ P P + W +NN+ V+ + D ++K KD G YT+ A
Sbjct: 366 VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
Query: 808 ENSEGIAETSAVITVEEPTEENAEPP 833
N G+ + + V + P
Sbjct: 426 VNEAGVTTCNTRLDVTARPNQTLPAP 451
Score = 77.0 bits (181), Expect = 7e-13
Identities = 65/251 (25%), Positives = 108/251 (43%), Gaps = 30/251 (11%)
Query: 497 VFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDF 556
V ++ +E+ P F++ +G + + +V G P P ++W+ ++
Sbjct: 237 VNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLH 296
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXX 616
+M + + +L+ V DAG + CVAKN AG A+ T +L V A +H
Sbjct: 297 KMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA--KEHKR------- 347
Query: 617 XXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP 676
P F KP+++ V EG + LEC++ AIP P + W + E+V
Sbjct: 348 ----------------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK-RNNEMVQ 390
Query: 677 DENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ 736
+++ D ++L I +V K G YTV AVN G + L + P Q
Sbjct: 391 FNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTA---RPNQ 446
Query: 737 VIEPLKSMIVR 747
+ K + VR
Sbjct: 447 TLPAPKQLRVR 457
Score = 74.9 bits (176), Expect = 3e-12
Identities = 52/196 (26%), Positives = 99/196 (50%), Gaps = 10/196 (5%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK----SDGDTHSI 789
PP+ I+ ++M + +G + +V G P P ++W N + V++ S+ HS+
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT 849
I + + D G Y A+N G E + + ++ +E+ P+FI + Q V E +
Sbjct: 309 -IFEVVRASDAGAYACVAKNRAG--EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDS 365
Query: 850 IKLVARVTRNPVPSITWYRNNEIIS-PSETITQNFDGE-NIELVITNVDSEIDSGDYKCV 907
+KL +++ P P + W RNNE++ ++ I+ D + L+I +V+ + D+G Y
Sbjct: 366 VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKK-DAGWYTVS 424
Query: 908 ASNSAGKSSHGARVTI 923
A N AG ++ R+ +
Sbjct: 425 AVNEAGVTTCNTRLDV 440
Score = 57.6 bits (133), Expect = 5e-07
Identities = 35/150 (23%), Positives = 69/150 (46%), Gaps = 5/150 (3%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
++ +E PP FI + +++ E ++ +V+ P P ++WY N + +
Sbjct: 240 QDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMI 299
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI---DVEKVTFVKHLQKSYE 939
+ + +I V D+G Y CVA N AG+++ ++ + + ++ + +S +
Sbjct: 300 VSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK 359
Query: 940 TEEGKTVILECQTSHTVSTK--WYHNKKEI 967
EG +V LECQ S K W N + +
Sbjct: 360 VLEGDSVKLECQISAIPPPKLFWKRNNEMV 389
Score = 54.0 bits (124), Expect = 6e-06
Identities = 40/203 (19%), Positives = 83/203 (40%), Gaps = 10/203 (4%)
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK-----ATYE 1530
+ K P + +N++ + + G+P P V+WY +G+ +++ + +
Sbjct: 244 QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEK 303
Query: 1531 NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC---VVGIQQKPVITISNEDIKQKHKVG 1587
Y C+A N GE + V+ + K + +K G
Sbjct: 304 GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEG 363
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS--VIRIKELKRSHSSKYTI 1645
D + I IPPP++ W +N ++ + + ++ T + IK++ + + YT+
Sbjct: 364 DSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTV 423
Query: 1646 EASNTAGTSSVEVTLKVYDKPSK 1668
A N AG ++ L V +P++
Sbjct: 424 SAVNEAGVTTCNTRLDVTARPNQ 446
Score = 39.1 bits (87), Expect = 0.17
Identities = 22/96 (22%), Positives = 38/96 (39%), Gaps = 1/96 (1%)
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA-S 1344
+PP+ + I G + P P+ W +N + ++ K + K S
Sbjct: 248 YPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
L + V +DAG Y +N G A + + +L K
Sbjct: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
Score = 38.3 bits (85), Expect = 0.30
Identities = 42/209 (20%), Positives = 90/209 (43%), Gaps = 14/209 (6%)
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP I +N +++G + +++ A V W+ +G +Q + ++ + K
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
Query: 1165 IYDC-DLDDAGEYSCEVGNSKCTAILTVE-EPSINFTLRLPEFILVPANTDAY----LTV 1218
I++ DAG Y+C N A TV+ + R P FI P + + +
Sbjct: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
Query: 1219 EIPDETL---DVTWYKKKSVIE-DTEKFTLISDVKKR-TLIIRKCTEDDQCEYTCVLLD- 1272
E + + W + +++ +T++ +L D R TL+I+ + D YT ++
Sbjct: 369 ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
Query: 1273 -AKSTTKLKVEVVEFPPKIVDYEREYRIK 1300
+T +++V P + + ++ R++
Sbjct: 429 AGVTTCNTRLDVTARPNQTLPAPKQLRVR 457
>AF144477-1|AAD44754.1| 498|Homo sapiens myotilin protein.
Length = 498
Score = 88.6 bits (210), Expect = 2e-16
Identities = 55/206 (26%), Positives = 94/206 (45%), Gaps = 8/206 (3%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F + P+ +DEG ++ ++ +P PD++W G + D+ + I S+ ++
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD-LHKMIVSEKGLHS 307
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGES 751
+ ++ V+ G Y VA NR GEA+ + L + E K P I +S V +G+S
Sbjct: 308 LIFEV--VRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDS 365
Query: 752 VILSAQVVGNPRPTITWCKNNKPVK----ALPTKSDGDTHSITILKPKKVKDEGVYTLKA 807
V L Q+ P P + W +NN+ V+ + D ++K KD G YT+ A
Sbjct: 366 VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
Query: 808 ENSEGIAETSAVITVEEPTEENAEPP 833
N G+ + + V + P
Sbjct: 426 VNEAGVTTCNTRLDVTARPNQTLPAP 451
Score = 77.0 bits (181), Expect = 7e-13
Identities = 65/251 (25%), Positives = 108/251 (43%), Gaps = 30/251 (11%)
Query: 497 VFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDF 556
V ++ +E+ P F++ +G + + +V G P P ++W+ ++
Sbjct: 237 VNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLH 296
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXX 616
+M + + +L+ V DAG + CVAKN AG A+ T +L V A +H
Sbjct: 297 KMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA--KEHKR------- 347
Query: 617 XXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP 676
P F KP+++ V EG + LEC++ AIP P + W + E+V
Sbjct: 348 ----------------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK-RNNEMVQ 390
Query: 677 DENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ 736
+++ D ++L I +V K G YTV AVN G + L + P Q
Sbjct: 391 FNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTA---RPNQ 446
Query: 737 VIEPLKSMIVR 747
+ K + VR
Sbjct: 447 TLPAPKQLRVR 457
Score = 74.9 bits (176), Expect = 3e-12
Identities = 52/196 (26%), Positives = 99/196 (50%), Gaps = 10/196 (5%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK----SDGDTHSI 789
PP+ I+ ++M + +G + +V G P P ++W N + V++ S+ HS+
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT 849
I + + D G Y A+N G E + + ++ +E+ P+FI + Q V E +
Sbjct: 309 -IFEVVRASDAGAYACVAKNRAG--EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDS 365
Query: 850 IKLVARVTRNPVPSITWYRNNEIIS-PSETITQNFDGE-NIELVITNVDSEIDSGDYKCV 907
+KL +++ P P + W RNNE++ ++ I+ D + L+I +V+ + D+G Y
Sbjct: 366 VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKK-DAGWYTVS 424
Query: 908 ASNSAGKSSHGARVTI 923
A N AG ++ R+ +
Sbjct: 425 AVNEAGVTTCNTRLDV 440
Score = 57.6 bits (133), Expect = 5e-07
Identities = 35/150 (23%), Positives = 69/150 (46%), Gaps = 5/150 (3%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
++ +E PP FI + +++ E ++ +V+ P P ++WY N + +
Sbjct: 240 QDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMI 299
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI---DVEKVTFVKHLQKSYE 939
+ + +I V D+G Y CVA N AG+++ ++ + + ++ + +S +
Sbjct: 300 VSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK 359
Query: 940 TEEGKTVILECQTSHTVSTK--WYHNKKEI 967
EG +V LECQ S K W N + +
Sbjct: 360 VLEGDSVKLECQISAIPPPKLFWKRNNEMV 389
Score = 54.0 bits (124), Expect = 6e-06
Identities = 40/203 (19%), Positives = 83/203 (40%), Gaps = 10/203 (4%)
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK-----ATYE 1530
+ K P + +N++ + + G+P P V+WY +G+ +++ + +
Sbjct: 244 QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEK 303
Query: 1531 NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC---VVGIQQKPVITISNEDIKQKHKVG 1587
Y C+A N GE + V+ + K + +K G
Sbjct: 304 GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEG 363
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS--VIRIKELKRSHSSKYTI 1645
D + I IPPP++ W +N ++ + + ++ T + IK++ + + YT+
Sbjct: 364 DSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTV 423
Query: 1646 EASNTAGTSSVEVTLKVYDKPSK 1668
A N AG ++ L V +P++
Sbjct: 424 SAVNEAGVTTCNTRLDVTARPNQ 446
Score = 39.1 bits (87), Expect = 0.17
Identities = 22/96 (22%), Positives = 38/96 (39%), Gaps = 1/96 (1%)
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA-S 1344
+PP+ + I G + P P+ W +N + ++ K + K S
Sbjct: 248 YPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
L + V +DAG Y +N G A + + +L K
Sbjct: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
Score = 38.3 bits (85), Expect = 0.30
Identities = 42/209 (20%), Positives = 90/209 (43%), Gaps = 14/209 (6%)
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP I +N +++G + +++ A V W+ +G +Q + ++ + K
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
Query: 1165 IYDC-DLDDAGEYSCEVGNSKCTAILTVE-EPSINFTLRLPEFILVPANTDAY----LTV 1218
I++ DAG Y+C N A TV+ + R P FI P + + +
Sbjct: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
Query: 1219 EIPDETL---DVTWYKKKSVIE-DTEKFTLISDVKKR-TLIIRKCTEDDQCEYTCVLLD- 1272
E + + W + +++ +T++ +L D R TL+I+ + D YT ++
Sbjct: 369 ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
Query: 1273 -AKSTTKLKVEVVEFPPKIVDYEREYRIK 1300
+T +++V P + + ++ R++
Sbjct: 429 AGVTTCNTRLDVTARPNQTLPAPKQLRVR 457
>AF133820-1|AAD29051.2| 498|Homo sapiens titin-like protein
protein.
Length = 498
Score = 88.6 bits (210), Expect = 2e-16
Identities = 55/206 (26%), Positives = 94/206 (45%), Gaps = 8/206 (3%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYC 692
PP F + P+ +DEG ++ ++ +P PD++W G + D+ + I S+ ++
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDD-LHKMIVSEKGLHS 307
Query: 693 SVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGE-KEPPQVIEPLKSMIVRQGES 751
+ ++ V+ G Y VA NR GEA+ + L + E K P I +S V +G+S
Sbjct: 308 LIFEV--VRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDS 365
Query: 752 VILSAQVVGNPRPTITWCKNNKPVK----ALPTKSDGDTHSITILKPKKVKDEGVYTLKA 807
V L Q+ P P + W +NN+ V+ + D ++K KD G YT+ A
Sbjct: 366 VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSA 425
Query: 808 ENSEGIAETSAVITVEEPTEENAEPP 833
N G+ + + V + P
Sbjct: 426 VNEAGVTTCNTRLDVTARPNQTLPAP 451
Score = 77.0 bits (181), Expect = 7e-13
Identities = 65/251 (25%), Positives = 108/251 (43%), Gaps = 30/251 (11%)
Query: 497 VFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDF 556
V ++ +E+ P F++ +G + + +V G P P ++W+ ++
Sbjct: 237 VNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLH 296
Query: 557 QMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXX 616
+M + + +L+ V DAG + CVAKN AG A+ T +L V A +H
Sbjct: 297 KMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA--KEHKR------- 347
Query: 617 XXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVP 676
P F KP+++ V EG + LEC++ AIP P + W + E+V
Sbjct: 348 ----------------APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWK-RNNEMVQ 390
Query: 677 DENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ 736
+++ D ++L I +V K G YTV AVN G + L + P Q
Sbjct: 391 FNTDRISLYQDNTGRVTLL-IKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTA---RPNQ 446
Query: 737 VIEPLKSMIVR 747
+ K + VR
Sbjct: 447 TLPAPKQLRVR 457
Score = 74.9 bits (176), Expect = 3e-12
Identities = 52/196 (26%), Positives = 99/196 (50%), Gaps = 10/196 (5%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK----SDGDTHSI 789
PP+ I+ ++M + +G + +V G P P ++W N + V++ S+ HS+
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
Query: 790 TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT 849
I + + D G Y A+N G E + + ++ +E+ P+FI + Q V E +
Sbjct: 309 -IFEVVRASDAGAYACVAKNRAG--EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDS 365
Query: 850 IKLVARVTRNPVPSITWYRNNEIIS-PSETITQNFDGE-NIELVITNVDSEIDSGDYKCV 907
+KL +++ P P + W RNNE++ ++ I+ D + L+I +V+ + D+G Y
Sbjct: 366 VKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKK-DAGWYTVS 424
Query: 908 ASNSAGKSSHGARVTI 923
A N AG ++ R+ +
Sbjct: 425 AVNEAGVTTCNTRLDV 440
Score = 57.6 bits (133), Expect = 5e-07
Identities = 35/150 (23%), Positives = 69/150 (46%), Gaps = 5/150 (3%)
Query: 823 EEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQN 882
++ +E PP FI + +++ E ++ +V+ P P ++WY N + +
Sbjct: 240 QDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMI 299
Query: 883 FDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI---DVEKVTFVKHLQKSYE 939
+ + +I V D+G Y CVA N AG+++ ++ + + ++ + +S +
Sbjct: 300 VSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKK 359
Query: 940 TEEGKTVILECQTSHTVSTK--WYHNKKEI 967
EG +V LECQ S K W N + +
Sbjct: 360 VLEGDSVKLECQISAIPPPKLFWKRNNEMV 389
Score = 54.0 bits (124), Expect = 6e-06
Identities = 40/203 (19%), Positives = 83/203 (40%), Gaps = 10/203 (4%)
Query: 1476 ETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAK-----ATYE 1530
+ K P + +N++ + + G+P P V+WY +G+ +++ + +
Sbjct: 244 QEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEK 303
Query: 1531 NRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSC---VVGIQQKPVITISNEDIKQKHKVG 1587
Y C+A N GE + V+ + K + +K G
Sbjct: 304 GLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEG 363
Query: 1588 DEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTS--VIRIKELKRSHSSKYTI 1645
D + I IPPP++ W +N ++ + + ++ T + IK++ + + YT+
Sbjct: 364 DSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTV 423
Query: 1646 EASNTAGTSSVEVTLKVYDKPSK 1668
A N AG ++ L V +P++
Sbjct: 424 SAVNEAGVTTCNTRLDVTARPNQ 446
Score = 39.1 bits (87), Expect = 0.17
Identities = 22/96 (22%), Positives = 38/96 (39%), Gaps = 1/96 (1%)
Query: 1286 FPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSA-S 1344
+PP+ + I G + P P+ W +N + ++ K + K S
Sbjct: 248 YPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHS 307
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
L + V +DAG Y +N G A + + +L K
Sbjct: 308 LIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAK 343
Score = 38.3 bits (85), Expect = 0.30
Identities = 42/209 (20%), Positives = 90/209 (43%), Gaps = 14/209 (6%)
Query: 1106 PPEIITRLQNQKVNKGNKATFEIELTKGDAL-VRWFKDGSEIQFSNHIQLTIDGKKQKLK 1164
PP I +N +++G + +++ A V W+ +G +Q + ++ + K
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
Query: 1165 IYDC-DLDDAGEYSCEVGNSKCTAILTVE-EPSINFTLRLPEFILVPANTDAY----LTV 1218
I++ DAG Y+C N A TV+ + R P FI P + + +
Sbjct: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
Query: 1219 EIPDETL---DVTWYKKKSVIE-DTEKFTLISDVKKR-TLIIRKCTEDDQCEYTCVLLD- 1272
E + + W + +++ +T++ +L D R TL+I+ + D YT ++
Sbjct: 369 ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
Query: 1273 -AKSTTKLKVEVVEFPPKIVDYEREYRIK 1300
+T +++V P + + ++ R++
Sbjct: 429 AGVTTCNTRLDVTARPNQTLPAPKQLRVR 457
>L05606-1|AAA36339.1| 476|Homo sapiens protein ( Human myosin binding
protein H mRNA, complete cds. ).
Length = 476
Score = 87.8 bits (208), Expect = 4e-16
Identities = 67/302 (22%), Positives = 135/302 (44%), Gaps = 22/302 (7%)
Query: 1282 EVVEFPP-KIVDYEREYRIKR-GSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSID 1339
E +E P ++ + R+ I++ G V L + +Q P+P W N + + + + D
Sbjct: 167 ENIEAPKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGD 226
Query: 1340 SKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINI 1399
S L I+ + +D+G Y+L + A +++ +++KP PP +L++ + +
Sbjct: 227 QDSI-LFIRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPSSIRLLDVWGCNAAL 285
Query: 1400 CWDEPENTGNSTIIYYVVEYQEIDTTEWISV-KNITKTQTSIQNLKTNSSYRFRAYAVNE 1458
W P++TGN+ ++ Y+V+ + T +W +V + T +I +L +SY FR ++ N
Sbjct: 286 QWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSENL 345
Query: 1459 VDISDASETTEYYKVIKETKI-------------QSPTVEKPLKNITTEPNEDIELTCIF 1505
+S ++ T+ I++ I ++P+ +PL + T+ P +L C
Sbjct: 346 CGLSTSATVTKELAHIQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSV 405
Query: 1506 GGVPQPKVTWYRDGKKL----KTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVET 1561
+ Q K+ W ++ ++ K + + Y C A N GE
Sbjct: 406 -ELHQAKIIWMKNKMEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASV 464
Query: 1562 SC 1563
C
Sbjct: 465 DC 466
Score = 72.5 bits (170), Expect = 1e-11
Identities = 43/167 (25%), Positives = 81/167 (48%), Gaps = 5/167 (2%)
Query: 1585 KVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYT 1644
+VG+ + +G P P+ W NG+ L++ + ++ T ++ S++ I+ +RS S +Y
Sbjct: 187 QVGETVNLQIPFQGKPKPQATWTHNGHALDSQR-VSMRTGDQDSILFIRSAQRSDSGRYE 245
Query: 1645 IEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
+ + + + V +KP P + + ++ + ++W PP D G EL Y ++
Sbjct: 246 LTVRVEDLEAKAVIDILVIEKPGPPSS-IRLLDVWGCNAALQWTPPQDTGNTELLGYMVQ 304
Query: 1705 KHEPDNNRWIKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFS 1750
K + +W V ++R T C I L Y FRV ++N G S
Sbjct: 305 KADKKTGQWFTV--LERYHPTTCTISDLIIGNSYSFRVFSENLCGLS 349
Score = 61.3 bits (142), Expect = 4e-08
Identities = 37/155 (23%), Positives = 69/155 (44%), Gaps = 7/155 (4%)
Query: 1379 DKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITKT 1436
D PS P + ++ SSS+ + W+ PE G + YV+E +EW +S + + T
Sbjct: 69 DVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMVT 128
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKP---LKNITT 1493
Q +++NL + R AV+ + + + I++P + P +
Sbjct: 129 QQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHI--RENIEAPKIRVPRHLRQTYIR 186
Query: 1494 EPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKAT 1528
+ E + L F G P+P+ TW +G L + + +
Sbjct: 187 QVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVS 221
Score = 48.0 bits (109), Expect = 4e-04
Identities = 35/114 (30%), Positives = 53/114 (46%), Gaps = 5/114 (4%)
Query: 492 IDKLPVFEKPTS---EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA 548
I K + KP + S AP F + L + G + Q C VE + + +I W +
Sbjct: 361 IQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSVELH-QAKIIWMKNKM 419
Query: 549 IIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
I+ + ++ + V TL IR+ P D+G +TC A N G AS L V+A
Sbjct: 420 EIQGNPKYRAL-SEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVKA 472
Score = 46.8 bits (106), Expect = 9e-04
Identities = 24/102 (23%), Positives = 44/102 (43%), Gaps = 1/102 (0%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
PS P + + +S SVT+ W PE G + Y++E W + V +
Sbjct: 71 PSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMVTQQ 130
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVP 1966
+ N+ D+ + R+SA ++ G P Q + + ++ P
Sbjct: 131 TVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIRENIEAP 172
Score = 45.2 bits (102), Expect = 0.003
Identities = 35/150 (23%), Positives = 62/150 (41%), Gaps = 4/150 (2%)
Query: 1621 ITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMR--EI 1678
+ T E + + E R + A T+S T P P+++ ++
Sbjct: 24 VPTAEPPGEVAVSESTREEQVPKPHGPAPQAPTAST-ATKPAPPSEDVPSAPLLLTLDDV 82
Query: 1679 SRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYM 1738
S SVT+ W+PP G L L Y +E + W+ V+ V ++ L +++
Sbjct: 83 SSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMVTQQTVRNLALGDKFL 142
Query: 1739 FRVIAQNPVGFS-EALESEPIVIKTALDVP 1767
RV A + G A+ +PI I+ ++ P
Sbjct: 143 LRVSAVSSAGAGPPAMLDQPIHIRENIEAP 172
Score = 45.2 bits (102), Expect = 0.003
Identities = 65/299 (21%), Positives = 114/299 (38%), Gaps = 31/299 (10%)
Query: 1765 DVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWKXXXXXXXXX 1823
DVPS + + SV ++W P E+ G + Y +E+ +EG +W
Sbjct: 69 DVPSAPLLLTLDD-VSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMV 127
Query: 1824 AR--IQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPS--QPRNFVVSESTS 1879
+ ++ L++ + R+ A + G P D I I + + P PR+
Sbjct: 128 TQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIRENIEAPKIRVPRH-------- 179
Query: 1880 RSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIE-NIKEKDEIIF 1938
L+ T G + + K +WT G ++ + ++D I+F
Sbjct: 180 ----LRQTYIRQVGETVNLQIPFQGKPKPQATWTHN---GHALDSQRVSMRTGDQDSILF 232
Query: 1939 RISAENTVGVSLPTESQSVRLEKHATV-------PSPPTAPLEIRMVGSNIVMTSWGTPE 1991
SA+ + + LE A + P PP++ + + G N + W P+
Sbjct: 233 IRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPSSIRLLDVWGCNAAL-QWTPPQ 291
Query: 1992 WDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLS 2050
G LLGY + D W V + + I DL ++Y R+++ N GLS
Sbjct: 292 DTGNTELLGYMVQKADKKTGQWFTVLE-RYHPTTCTISDLIIGNSYSFRVFSENLCGLS 349
Score = 43.2 bits (97), Expect = 0.010
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 7/106 (6%)
Query: 1963 ATVPSPPT-----APLEIRM--VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWME 2015
AT P+PP+ APL + + V S+ V SW PE G L GY + + + W+
Sbjct: 60 ATKPAPPSEDVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVP 119
Query: 2016 VGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKV 2061
V + + +R+L+ +++R+ A + G P D+P +
Sbjct: 120 VSARPMMVTQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHI 165
Score = 39.9 bits (89), Expect = 0.098
Identities = 29/99 (29%), Positives = 48/99 (48%), Gaps = 7/99 (7%)
Query: 733 EPPQVIEP--LKSMIVRQ-GESVILSAQVVGNPRPTITWCKNNKPVKA-LPTKSDGDTHS 788
E P++ P L+ +RQ GE+V L G P+P TW N + + + GD S
Sbjct: 170 EAPKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGDQDS 229
Query: 789 ITILKPKKVKDEGVY--TLKAENSEGIAETSAVITVEEP 825
I ++ + D G Y T++ E+ E A ++ +E+P
Sbjct: 230 ILFIRSAQRSDSGRYELTVRVEDLEAKAVID-ILVIEKP 267
Score = 37.1 bits (82), Expect = 0.69
Identities = 16/60 (26%), Positives = 33/60 (55%)
Query: 1603 EVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV 1662
++IW KN +++ + +Y +++ + I++ S YT +A N G +SV+ L+V
Sbjct: 411 KIIWMKNKMEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASVDCRLEV 470
Score = 34.3 bits (75), Expect = 4.9
Identities = 19/90 (21%), Positives = 39/90 (43%), Gaps = 2/90 (2%)
Query: 1786 ITWFPSEKNGGSPIIDYKVEI--KQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARN 1843
+ W P + G + ++ Y V+ K+ G+ + I L I +Y FR+++ N
Sbjct: 285 LQWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSEN 344
Query: 1844 EIGTSLPYTSDDKITIGKTLTPPSQPRNFV 1873
G S T ++ + ++P+ F+
Sbjct: 345 LCGLSTSATVTKELAHIQKADIAAKPKGFI 374
Score = 33.9 bits (74), Expect = 6.4
Identities = 30/96 (31%), Positives = 45/96 (46%), Gaps = 9/96 (9%)
Query: 1192 EEPSINFTLRLPEFILVPA-NTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKK 1250
E PS FT L + P +T + +VE+ + W K K I+ K+ +S+
Sbjct: 380 EAPS--FTQPLADHTSTPGYSTQLFCSVEL--HQAKIIWMKNKMEIQGNPKYRALSEQGV 435
Query: 1251 RTLIIRKCTEDDQCEYTC----VLLDAKSTTKLKVE 1282
TL IRK + D YTC VL +A +L+V+
Sbjct: 436 CTLEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVK 471
>AK128233-1|BAC87343.1| 1172|Homo sapiens protein ( Homo sapiens cDNA
FLJ46367 fis, clone TESTI4051424, weakly similar to
M-protein, striated muscle. ).
Length = 1172
Score = 87.8 bits (208), Expect = 4e-16
Identities = 84/316 (26%), Positives = 135/316 (42%), Gaps = 39/316 (12%)
Query: 1779 IDNESVYITWFPSEKNGGSPIIDYKVEIKQ-EGKKWKXXXXXXXXXAR--IQKLSINTTY 1835
++ + + +TW P G+PI Y +E Q E +W R I+ L +Y
Sbjct: 119 VNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWIACHEAPGGTCRCPIRGLVEGQSY 178
Query: 1836 QFRIYARNEIGTS----------------------LPYTSDDKITIGK-----TLTPPSQ 1868
+FR+ A + +G+S +P+ +KITI T+T PS
Sbjct: 179 RFRVRAISRVGSSVPSKASELVVMGDHDAARRKTEIPFDLGNKITISTDAFEDTVTIPSP 238
Query: 1869 PRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGG-SVHEHCI 1927
P N SE V L W EP G +P+T Y +E + +W I + +
Sbjct: 239 PTNVHASEIREAYVVLAWEEPSPRGRAPLT-YSLEKSVIGSGTWEAISSESPVRSPRFAV 297
Query: 1928 ENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLE-KHATVPSPPTAPLEIRMVGSNIVMT 1985
++++K +FR+ A N G+S P+E S+ + L AT+P PP R +++ +T
Sbjct: 298 LDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLP-PPAQVQAFRDTQTSVSLT 356
Query: 1986 SWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARN 2045
W P D LLGY I R V + W V + +F + L Y + + +
Sbjct: 357 -W-DPVKD--PELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPRLRTGKEYEFCVRSVS 412
Query: 2046 EIGLSEPLESDEPFKV 2061
E G+ E + EP +V
Sbjct: 413 EAGVGESSAATEPIRV 428
Score = 85.4 bits (202), Expect = 2e-15
Identities = 80/332 (24%), Positives = 131/332 (39%), Gaps = 16/332 (4%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTS-----SVEVTLKVYDKPSKPEGPVIMREISRESVTIE 1686
+ +L++ S + + A N G S S + L+ P V ++ SV++
Sbjct: 297 VLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQTSVSLT 356
Query: 1687 WKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNP 1746
W P D EL Y I + + W V + + + +L EY F V + +
Sbjct: 357 WDPVKDP---ELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPRLRTGKEYEFCVRSVSE 413
Query: 1747 VGFSEA-LESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVE 1805
G E+ +EPI +K AL PS NE V I W P ++ GG I+ Y ++
Sbjct: 414 AGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEMV-IGWKPPKRRGGGKILGYFLD 472
Query: 1806 IKQ-EGKKWKXXXXXX--XXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK- 1861
E W ++ L Y+FR A N G +
Sbjct: 473 QHDSEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEW 532
Query: 1862 TLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGS 1921
T+ P P + SE + S+ L+W P G P+T Y + F+ + W K VT G
Sbjct: 533 TMPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQW-KPVTPGPI 591
Query: 1922 VHEHC-IENIKEKDEIIFRISAENTVGVSLPT 1952
H + +++ +F++ A N+ G+ P+
Sbjct: 592 SGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPS 623
Score = 71.3 bits (167), Expect = 3e-11
Identities = 65/276 (23%), Positives = 109/276 (39%), Gaps = 16/276 (5%)
Query: 1784 VYITWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXA---RIQKLSINTTYQFRI 1839
V + W G +P+ Y +E G W+ + + L +Y FR+
Sbjct: 252 VVLAWEEPSPRGRAPLT-YSLEKSVIGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRV 310
Query: 1840 YARNEIGTSLPYTSDDKITIG---KTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
A N+ G S P + I + TL PP+Q + F T SV+L W +P +
Sbjct: 311 RAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAF---RDTQTSVSLTW-DPVKD--PE 364
Query: 1897 ITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTES-Q 1955
+ Y I + V W + + ++ E F + + + GV + + +
Sbjct: 365 LLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPRLRTGKEYEFCVRSVSEAGVGESSAATE 424
Query: 1956 SVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWME 2015
+R+++ PS P + G N ++ W P+ GG +LGY + D + W
Sbjct: 425 PIRVKQALATPSAPYG-FALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHA 483
Query: 2016 VGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSE 2051
V + + T + DL E H Y R A N G+ E
Sbjct: 484 VNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGE 519
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/161 (22%), Positives = 73/161 (45%), Gaps = 6/161 (3%)
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYD- 1664
W+++G+ L + + I ++ + +++ + YT+ + G + V D
Sbjct: 41 WFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYTVRVPSPFGPREQSTYVLVRDA 100
Query: 1665 ---KPSKPEGPVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADV 1719
P P P+ +R +++R+ + + W PP D G +T Y IE+ + ++ WI +
Sbjct: 101 EAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWIACHEA 160
Query: 1720 DRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVI 1760
I+ L E Y FRV A + VG S ++ +V+
Sbjct: 161 PGGTCRCPIRGLVEGQSYRFRVRAISRVGSSVPSKASELVV 201
Score = 61.7 bits (143), Expect = 3e-08
Identities = 48/215 (22%), Positives = 81/215 (37%), Gaps = 6/215 (2%)
Query: 1649 NTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEP 1708
++A T + V + PS P G ++ + + I WKPP GG ++ Y +++H+
Sbjct: 419 SSAATEPIRVK-QALATPSAPYGFALLN-CGKNEMVIGWKPPKRRGGGKILGYFLDQHDS 476
Query: 1709 DNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPS 1768
+ W V + L+E Y FR A N G E + +P
Sbjct: 477 EELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEWTMPQ 536
Query: 1769 -XXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEG-KKWK--XXXXXXXXXA 1824
+ S+ + W P G P+ Y V ++EG ++WK
Sbjct: 537 PGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISGTHL 596
Query: 1825 RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
R+ L +Y F++ A N G P D + +
Sbjct: 597 RVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLL 631
Score = 60.5 bits (140), Expect = 6e-08
Identities = 39/159 (24%), Positives = 72/159 (45%), Gaps = 9/159 (5%)
Query: 1320 EWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILD 1379
+W + +++ + K + ASL + D G+Y +R+ + G + V + D
Sbjct: 40 QWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYTVRVPSPFGPREQSTYVLVRD 99
Query: 1380 ----KPSPPGKP-NI--LEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN 1432
P PG P N+ L+++ + + W P +T + I Y +E + ++ EWI+
Sbjct: 100 AEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWIACHE 159
Query: 1433 IT--KTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+ I+ L SYRFR A++ V S S+ +E
Sbjct: 160 APGGTCRCPIRGLVEGQSYRFRVRAISRVGSSVPSKASE 198
Score = 56.4 bits (130), Expect = 1e-06
Identities = 54/221 (24%), Positives = 87/221 (39%), Gaps = 29/221 (13%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P P N + + L W P G+PIT Y IE + W G
Sbjct: 108 PGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWIACHEAPGGTCRC 167
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKH------ATVP------------ 1966
I + E FR+ A + VG S+P++ S+ V + H +P
Sbjct: 168 PIRGLVEGQSYRFRVRAISRVGSSVPSKASELVVMGDHDAARRKTEIPFDLGNKITISTD 227
Query: 1967 ------SPPTAPLEIRM--VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV-G 2017
+ P+ P + + V+ +W P G APL Y++ + W +
Sbjct: 228 AFEDTVTIPSPPTNVHASEIREAYVVLAWEEPSPRGRAPLT-YSLEKSVIGSGTWEAISS 286
Query: 2018 KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEP 2058
+ V + +F + DL + +Y+ R+ A N+ GLS+P E EP
Sbjct: 287 ESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEP 327
Score = 48.8 bits (111), Expect = 2e-04
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 4/92 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
PSPP + EI + + + W+EP G + + Y +E I + W ++ + + +
Sbjct: 236 PSPPTNVHASEIREAYVVLAWEEPSPRGRAPLT-YSLEKSVIGSGTWEAISSESPVRSPR 294
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
++ +L+ SY FR A+N+ +SD SE +E
Sbjct: 295 FAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSE 326
Score = 46.8 bits (106), Expect = 9e-04
Identities = 30/141 (21%), Positives = 67/141 (47%), Gaps = 11/141 (7%)
Query: 1341 KSASLTIKKVENTDAGIYKLRLENNCGHADVEMN---VTILDKPS---PPGKPNILEIDS 1394
+S + +E + ++++R N G +D + + P+ PP +
Sbjct: 291 RSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQ 350
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFR 1452
+S+++ WD ++ ++ Y + +++ T+EW +V N I T+ ++ L+T Y F
Sbjct: 351 TSVSLTWDPVKDP---ELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPRLRTGKEYEFC 407
Query: 1453 AYAVNEVDISDASETTEYYKV 1473
+V+E + ++S TE +V
Sbjct: 408 VRSVSEAGVGESSAATEPIRV 428
Score = 46.4 bits (105), Expect = 0.001
Identities = 52/205 (25%), Positives = 88/205 (42%), Gaps = 21/205 (10%)
Query: 740 PLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKK 796
PLK +G + + TW +K +++ + T + D + IL PK
Sbjct: 961 PLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKRLESGDRIRTGTTLDEIWLHILDPKD 1020
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE----PPLFI---NRFQEI------- 842
D+G YTL+ + + + S ++ + + AE L I NR + +
Sbjct: 1021 -SDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEHQRLKTLAIIEKNRAKVVRGLPDVA 1079
Query: 843 TVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSG 902
T+ E T+ L V+ +P P I+W +N++ ++ + G + + I V+SE DSG
Sbjct: 1080 TIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVTITIEKVNSE-DSG 1138
Query: 903 DYKCVASNSAGKSSHGARVTIDVEK 927
Y N G S +VTI V K
Sbjct: 1139 RYGVFVKNKYG--SETGQVTISVFK 1161
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/130 (24%), Positives = 57/130 (43%), Gaps = 7/130 (5%)
Query: 1932 EKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP--PTAPLEIRMVGSN--IVMTSW 1987
++DE ++ + + G P E + L + A +P P +PL +R + N ++ +W
Sbjct: 72 KEDEGLYTVRVPSPFG---PREQSTYVLVRDAEAENPGAPGSPLNVRCLDVNRDCLILTW 128
Query: 1988 GTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEI 2047
P G P+ Y I W+ + T + IR L E +Y R+ A + +
Sbjct: 129 APPSDTRGNPITAYTIERCQGESGEWIACHEAPGGTCRCPIRGLVEGQSYRFRVRAISRV 188
Query: 2048 GLSEPLESDE 2057
G S P ++ E
Sbjct: 189 GSSVPSKASE 198
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/94 (24%), Positives = 45/94 (47%), Gaps = 2/94 (2%)
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW--ISVKNITK 1435
+ +P PP E+ ++S+ + W+ P G + Y V +QE + +W ++ I+
Sbjct: 534 MPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISG 593
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
T + +L+ SY F+ A+N + S T+
Sbjct: 594 THLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTD 627
Score = 44.8 bits (101), Expect = 0.003
Identities = 91/398 (22%), Positives = 151/398 (37%), Gaps = 55/398 (13%)
Query: 458 VQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDKL--PVFEKPTSEEQSMAPIFVEK 515
+Q E+KG AQ L D Q +++ DKL K ++ P F
Sbjct: 802 IQNLSEEDKGSYTAQ-LRDGKAKNQITLTLVDDDFDKLLRKADAKRRDWKRKQGPYFERP 860
Query: 516 LRPKHTPDGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVF 574
L+ K T D VQ C+V + + WF Q A + Q Y + L I E+
Sbjct: 861 LQWKVTED-CQVQLTCKVTNTKKETRFQWFFQRAEMPDGQ----YDPETGTGLLCIEELS 915
Query: 575 PEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPP 634
+D G + + + D G + T+ ++ G
Sbjct: 916 KKDKGIYRAMVSD------------------DRGEDDTILDLTGDALDAIFTEL--GRIG 955
Query: 635 TFSKKP-KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
S P K Q +EG I + + + W K + + + I D
Sbjct: 956 ALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKRLESGDRIRTGTTLDEIW--- 1012
Query: 694 VLKITNVKKFQEGTYTV-VAVNRE---------GEA---SLPIVLKIKTG---EKEPPQV 737
L I + K +G YT+ +A +E G+A ++ ++KT EK +V
Sbjct: 1013 -LHILDPKDSDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEHQRLKTLAIIEKNRAKV 1071
Query: 738 IEPLKSMI-VRQGESVILSAQVVGNPRPTITWCKNNKPVKALP---TKSDGDTHSITILK 793
+ L + + + +++ L+ V G+P P I+W KN++PV L + G +ITI K
Sbjct: 1072 VRGLPDVATIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVTITIEK 1131
Query: 794 PKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+D G Y + +N G I+V + +E E
Sbjct: 1132 VNS-EDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKE 1168
Score = 44.4 bits (100), Expect = 0.005
Identities = 19/79 (24%), Positives = 38/79 (48%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
+T ++ G P PE+ W KN + Y + + I I+++ S +Y + N
Sbjct: 1089 LTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKY 1148
Query: 1652 GTSSVEVTLKVYDKPSKPE 1670
G+ + +VT+ V+ +P+
Sbjct: 1149 GSETGQVTISVFKHGDEPK 1167
Score = 41.1 bits (92), Expect = 0.042
Identities = 37/167 (22%), Positives = 67/167 (40%), Gaps = 12/167 (7%)
Query: 1320 EW-IVNSKIIKKCKHTKPSIDS-KSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTI 1377
EW VN+K I+ + T P + + K ++ V G E++ + +
Sbjct: 379 EWQTVNNKPIQGTRFTVPRLRTGKEYEFCVRSVSEAGVG------ESSAATEPIRVKQA- 431
Query: 1378 LDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITK 1435
L PS P +L + + I W P+ G I+ Y ++ + + +W +V I
Sbjct: 432 LATPSAPYGFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHAVNQQPIPT 491
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSP 1482
+ +L Y FRA A N + + S + ++ KE + P
Sbjct: 492 RVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFE-CKEWTMPQP 537
Score = 34.3 bits (75), Expect = 4.9
Identities = 32/184 (17%), Positives = 75/184 (40%), Gaps = 22/184 (11%)
Query: 1223 ETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE 1282
E + TW+ K +E ++ + + + L I + D+ +YT + K +L +
Sbjct: 983 EYMKTTWFHKDKRLESGDRIRTGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEVRQLSTD 1042
Query: 1283 VV--EFPPKIVDYER----------EYRIKRG-SDVTLLVDYQAF---------PQPNDE 1320
+ F + +++R ++ RG DV +++ + P P
Sbjct: 1043 LSGQAFEDAMAEHQRLKTLAIIEKNRAKVVRGLPDVATIMEDKTLCLTCIVSGDPTPEIS 1102
Query: 1321 WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
W+ N + + + + ++TI+KV + D+G Y + ++N G ++ +++
Sbjct: 1103 WLKNDQPVTFLDRYRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKYGSETGQVTISVFKH 1162
Query: 1381 PSPP 1384
P
Sbjct: 1163 GDEP 1166
Score = 33.9 bits (74), Expect = 6.4
Identities = 20/68 (29%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1036 LEVEINSETADV-VWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE 1094
LEVE S A++ + + EI K +F++ + ++ I+N S D+G Y+ LRD
Sbjct: 761 LEVEKLSPAAELHLIFNNKEIFSSPNRKINFDREKGLVEVIIQNLSEEDKGSYTAQLRDG 820
Query: 1095 SCTAEVTV 1102
++T+
Sbjct: 821 KAKNQITL 828
>BC104918-1|AAI04919.1| 1208|Homo sapiens CHL1 protein protein.
Length = 1208
Score = 87.4 bits (207), Expect = 5e-16
Identities = 173/823 (21%), Positives = 308/823 (37%), Gaps = 56/823 (6%)
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+++ ++ K + + PP E I +G + L + P P +W + K
Sbjct: 224 VNSSNSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPK 283
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
+ K ++ +L I+ V D G Y+ N G A + +V + + P KP
Sbjct: 284 GREAK---ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSA 340
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ S I E E T I + V +D + + + S NL+ N +
Sbjct: 341 VYSTGSNGILLCEAEGEPQPT-IKWRVNGSPVDNHPFAG-DVVFPREISFTNLQPNHT-- 396
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
AV + + S+ T I ++ K +N T L C F P+
Sbjct: 397 ----AVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPE 452
Query: 1511 PKVTWYR--DGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
V+W + + K L+ + Y C N G+ + + I+
Sbjct: 453 AVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIR 512
Query: 1569 QKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEK 1626
+ +S N I + H + ++ W K+G E + +
Sbjct: 513 NATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIID 572
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT-LKVYDKPSKPEGPVIMREISRESVTI 1685
+ + I + Y A +TA S+ ++T + V D P PE + + E SV +
Sbjct: 573 GANLTISNVTLEDQGIYCCSA-HTALDSAADITQVTVLDVPDPPEN-LHLSERQNRSVRL 630
Query: 1686 EWKPPLDDGGLELTKYAIE----KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRV 1741
W+ D +++Y +E K EP RW ++ V + +T I L Y FRV
Sbjct: 631 TWEAGADHNS-NISEYIVEFEGNKEEP--GRWEELTRV-QGKKTTVILPLAPFVRYQFRV 686
Query: 1742 IAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSP 1798
IA N VG S+ + +T P + + I W P E+NG P
Sbjct: 687 IAVNEVGRSQPSQPSD-HHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNG--P 743
Query: 1799 IIDYKVEIKQEGK--KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDK 1856
++Y+V K +G +W+ R+ ++ Y ++ A N++G+ P
Sbjct: 744 GLEYRVTWKPQGAPVEWE-EETVTNHTLRVMTPAVYAPYDVKVQAINQLGSG-PDPQSVT 801
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKW-TEPESNGGSPITNYIIE-FKT---VKGKS 1911
+ G+ P + P V S V + W T P+ + Y I +KT + G++
Sbjct: 802 LYSGEDY-PDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRT 860
Query: 1912 WTKIVTV---GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
K V + G + + ++ E + A N+ G ES+ + VP
Sbjct: 861 HPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAG--PESEPYIFQTPEGVPEQ 918
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM-EVGKVDVNT---L 2024
PT L++ V + SWG P+ G L GY + + + T + E+ +++ T
Sbjct: 919 PTF-LKVIKVDKDTATLSWGLPKKLNG-NLTGYLLQYQIINDTYEIGELNDINITTPSKP 976
Query: 2025 KFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGS 2067
+++ +L+ Y + A G +P+ + GEGS
Sbjct: 977 SWHLSNLNATTKYKFYLRACTSQGCGKPITEESS---TLGEGS 1016
Score = 77.0 bits (181), Expect = 7e-13
Identities = 93/360 (25%), Positives = 148/360 (41%), Gaps = 37/360 (10%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PPT S + + +G +LLEC +P P + W G ++ A E+ Y
Sbjct: 239 LPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRE---AKEN----Y 291
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
LKI NV +G Y A N G A+ + ++ EPP+ + +S + G +
Sbjct: 292 GKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVE----EPPRWTKKPQSAVYSTGSN 347
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSD---GDTHSITILKPKKVKDEGVYTLKAE 808
IL + G P+PTI W N PV P D S T L+P VY +A
Sbjct: 348 GILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHT---AVYQCEAS 404
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWY 867
N G +A I V + PL + E G + L +P ++W
Sbjct: 405 NVHGTILANANIDVVDVR------PLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQ 458
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ E + P E + EN L I N +E D+G Y C N+ GK++ +D+
Sbjct: 459 KVEE-VKPLEGRRYHI-YENGTLQI-NRTTEEDAGSYSCWVENAIGKTA--VTANLDIRN 513
Query: 928 VTFVKHLQKSYETEEGKTVILECQT------SHTVSTKWYHNKK--EISGMDHREIIQEG 979
T ++ K+ + + L C++ H++ W + + EI+G + II +G
Sbjct: 514 ATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDG 573
Score = 44.0 bits (99), Expect = 0.006
Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC EG P PQ+ W + + ++ + Y TL I V +D G + C
Sbjct: 255 GEILLLECFAEGLPTPQVDWNKIGGDLPKGREAKENYGK----TLKIENVSYQDKGNYRC 310
Query: 584 VAKNAAGFASSTTELIVEAP 603
A N G A+ +IVE P
Sbjct: 311 TASNFLGTATHDFHVIVEEP 330
Score = 42.7 bits (96), Expect = 0.014
Identities = 132/621 (21%), Positives = 226/621 (36%), Gaps = 60/621 (9%)
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVI-LSAQVVGNPRPTITWCKNNKPVKALPTKSD 783
++I + ++ P +I+ K + + + + GNP PT +W K+ P +
Sbjct: 25 IEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRII 84
Query: 784 GDTHSITILKPKK---VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQ 840
+S T P + +G Y A N GIA + + + + P +
Sbjct: 85 PSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVP-----SVPKFPKEKID 139
Query: 841 EITVKEKGTIKLVARVTRNPVPSITWYRNNEI--ISPSETITQNFDGENIELVITNVDSE 898
+ V+E I L + P ++ N E+ I E + + G +L NV+ +
Sbjct: 140 PLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKG---DLYFANVEEK 196
Query: 899 IDSGDYKCVAS---------NSAGKSSHGARVTIDVEKVTFV-----KHLQKSYETEEGK 944
DY C A+ K + + +I K + + S +G+
Sbjct: 197 DSRNDYCCFAAFPRLRTIVQKMPMKLTVNSSNSIKQRKPKLLLPPTESGSESSITILKGE 256
Query: 945 TVILECQTSHTVSTKWYHNKKEISG-MDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++LEC + + NK I G + +E D G +C +
Sbjct: 257 ILLLECFAEGLPTPQVDWNK--IGGDLPKGREAKENYGKTLKIENVSYQDKGNYRCTASN 314
Query: 1004 ---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEII--K 1057
T V+ E P + +K Q IL E E + W +G +
Sbjct: 315 FLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNH 374
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR-LQNQ 1116
P F + L +T+V+ + E S + A + VV++ P I T+ +N
Sbjct: 375 PFAGDVVFPREISFTNLQPNHTAVY-QCEASNVHGTILANANIDVVDVRPLIQTKDGENY 433
Query: 1117 KVNKGNKATFEIE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGE 1175
G A E +A+V W K E++ + I + L+I +DAG
Sbjct: 434 ATVVGYSAFLHCEFFASPEAVVSWQK-VEEVKPLEGRRYHI-YENGTLQINRTTEEDAGS 491
Query: 1176 YSCEVGNSKCTAILTVEEPSINFTL--------RLPEFILVPANTDAYLTVEIPDETLDV 1227
YSC V N+ +T N T R+P+ ++ + ++ + +L +
Sbjct: 492 YSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHL-KHSLKL 550
Query: 1228 TWYKKKSVIE--DTEKFTLISDVKKRTLIIRKCTEDDQCEYTC----VLLDAKSTTKLKV 1281
+W K E TE +I D L I T +DQ Y C L A T++ V
Sbjct: 551 SWSKDGEAFEINGTEDGRIIID--GANLTISNVTLEDQGIYCCSAHTALDSAADITQVTV 608
Query: 1282 EVVEFPPKIVDY-EREYRIKR 1301
V PP+ + ER+ R R
Sbjct: 609 LDVPDPPENLHLSERQNRSVR 629
Score = 37.1 bits (82), Expect = 0.69
Identities = 29/130 (22%), Positives = 49/130 (37%), Gaps = 3/130 (2%)
Query: 1251 RTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLV 1309
+TL I + D+ Y C + T V VE PP+ + GS+ LL
Sbjct: 293 KTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLC 352
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
+ + PQP +W VN + + + S T ++ +Y+ N G
Sbjct: 353 EAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFT--NLQPNHTAVYQCEASNVHGTI 410
Query: 1370 DVEMNVTILD 1379
N+ ++D
Sbjct: 411 LANANIDVVD 420
Score = 36.3 bits (80), Expect = 1.2
Identities = 56/249 (22%), Positives = 91/249 (36%), Gaps = 17/249 (6%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAI----LTVE 1192
V W K G ++ + + + LKI + D G Y C N TA + VE
Sbjct: 272 VDWNKIGGDLPKGREAK---ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVE 328
Query: 1193 EPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVK-KR 1251
EP +T + P+ + ++ L E E ++ D F DV R
Sbjct: 329 EPP-RWT-KKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFA--GDVVFPR 384
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKST--TKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLL 1308
+ + Y C + T ++VV+ P I + E Y G L
Sbjct: 385 EISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLH 444
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
++ A P+ W + +K + + I ++ +L I + DAG Y +EN G
Sbjct: 445 CEFFASPEAVVSW-QKVEEVKPLEGRRYHI-YENGTLQINRTTEEDAGSYSCWVENAIGK 502
Query: 1369 ADVEMNVTI 1377
V N+ I
Sbjct: 503 TAVTANLDI 511
Score = 35.1 bits (77), Expect = 2.8
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + C+ P ++W ++ +KP + + Y+ +N TL I EDAG+++C
Sbjct: 438 GYSAFLHCEFFASPEAVVSW-QKVEEVKPLEG-RRYHIYEN-GTLQINRTTEEDAGSYSC 494
Query: 584 VAKNAAGFASSTTEL 598
+NA G + T L
Sbjct: 495 WVENAIGKTAVTANL 509
>AB209329-1|BAD92566.1| 1210|Homo sapiens Neural cell adhesion
molecule variant protein.
Length = 1210
Score = 87.4 bits (207), Expect = 5e-16
Identities = 173/823 (21%), Positives = 308/823 (37%), Gaps = 56/823 (6%)
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKK 1330
+++ ++ K + + PP E I +G + L + P P +W + K
Sbjct: 226 VNSSNSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPK 285
Query: 1331 CKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNIL 1390
+ K ++ +L I+ V D G Y+ N G A + +V + + P KP
Sbjct: 286 GREAK---ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSA 342
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYR 1450
+ S I E E T I + V +D + + + S NL+ N +
Sbjct: 343 VYSTGSNGILLCEAEGEPQPT-IKWRVNGSPVDNHPFAG-DVVFPREISFTNLQPNHT-- 398
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQ 1510
AV + + S+ T I ++ K +N T L C F P+
Sbjct: 399 ----AVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPE 454
Query: 1511 PKVTWYR--DGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
V+W + + K L+ + Y C N G+ + + I+
Sbjct: 455 AVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIR 514
Query: 1569 QKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEK 1626
+ +S N I + H + ++ W K+G E + +
Sbjct: 515 NATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIID 574
Query: 1627 TSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT-LKVYDKPSKPEGPVIMREISRESVTI 1685
+ + I + Y A +TA S+ ++T + V D P PE + + E SV +
Sbjct: 575 GANLTISNVTLEDQGIYCCSA-HTALDSAADITQVTVLDVPDPPEN-LHLSERQNRSVRL 632
Query: 1686 EWKPPLDDGGLELTKYAIE----KHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRV 1741
W+ D +++Y +E K EP RW ++ V + +T I L Y FRV
Sbjct: 633 TWEAGADHNS-NISEYIVEFEGNKEEP--GRWEELTRV-QGKKTTVILPLAPFVRYQFRV 688
Query: 1742 IAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP---SEKNGGSP 1798
IA N VG S+ + +T P + + I W P E+NG P
Sbjct: 689 IAVNEVGRSQPSQPSD-HHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNG--P 745
Query: 1799 IIDYKVEIKQEGK--KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDK 1856
++Y+V K +G +W+ R+ ++ Y ++ A N++G+ P
Sbjct: 746 GLEYRVTWKPQGAPVEWE-EETVTNHTLRVMTPAVYAPYDVKVQAINQLGSG-PDPQSVT 803
Query: 1857 ITIGKTLTPPSQPRNFVVSESTSRSVTLKW-TEPESNGGSPITNYIIE-FKT---VKGKS 1911
+ G+ P + P V S V + W T P+ + Y I +KT + G++
Sbjct: 804 LYSGEDY-PDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRT 862
Query: 1912 WTKIVTV---GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSP 1968
K V + G + + ++ E + A N+ G ES+ + VP
Sbjct: 863 HPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAG--PESEPYIFQTPEGVPEQ 920
Query: 1969 PTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM-EVGKVDVNT---L 2024
PT L++ V + SWG P+ G L GY + + + T + E+ +++ T
Sbjct: 921 PTF-LKVIKVDKDTATLSWGLPKKLNG-NLTGYLLQYQIINDTYEIGELNDINITTPSKP 978
Query: 2025 KFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGS 2067
+++ +L+ Y + A G +P+ + GEGS
Sbjct: 979 SWHLSNLNATTKYKFYLRACTSQGCGKPITEESS---TLGEGS 1018
Score = 77.0 bits (181), Expect = 7e-13
Identities = 93/360 (25%), Positives = 148/360 (41%), Gaps = 37/360 (10%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PPT S + + +G +LLEC +P P + W G ++ A E+ Y
Sbjct: 241 LPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRE---AKEN----Y 293
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
LKI NV +G Y A N G A+ + ++ EPP+ + +S + G +
Sbjct: 294 GKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVE----EPPRWTKKPQSAVYSTGSN 349
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSD---GDTHSITILKPKKVKDEGVYTLKAE 808
IL + G P+PTI W N PV P D S T L+P VY +A
Sbjct: 350 GILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHT---AVYQCEAS 406
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWY 867
N G +A I V + PL + E G + L +P ++W
Sbjct: 407 NVHGTILANANIDVVDVR------PLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQ 460
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ E + P E + EN L I N +E D+G Y C N+ GK++ +D+
Sbjct: 461 KVEE-VKPLEGRRYHI-YENGTLQI-NRTTEEDAGSYSCWVENAIGKTA--VTANLDIRN 515
Query: 928 VTFVKHLQKSYETEEGKTVILECQT------SHTVSTKWYHNKK--EISGMDHREIIQEG 979
T ++ K+ + + L C++ H++ W + + EI+G + II +G
Sbjct: 516 ATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDG 575
Score = 44.0 bits (99), Expect = 0.006
Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC EG P PQ+ W + + ++ + Y TL I V +D G + C
Sbjct: 257 GEILLLECFAEGLPTPQVDWNKIGGDLPKGREAKENYGK----TLKIENVSYQDKGNYRC 312
Query: 584 VAKNAAGFASSTTELIVEAP 603
A N G A+ +IVE P
Sbjct: 313 TASNFLGTATHDFHVIVEEP 332
Score = 42.7 bits (96), Expect = 0.014
Identities = 132/621 (21%), Positives = 226/621 (36%), Gaps = 60/621 (9%)
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVI-LSAQVVGNPRPTITWCKNNKPVKALPTKSD 783
++I + ++ P +I+ K + + + + GNP PT +W K+ P +
Sbjct: 27 IEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRII 86
Query: 784 GDTHSITILKPKK---VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQ 840
+S T P + +G Y A N GIA + + + + P +
Sbjct: 87 PSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVP-----SVPKFPKEKID 141
Query: 841 EITVKEKGTIKLVARVTRNPVPSITWYRNNEI--ISPSETITQNFDGENIELVITNVDSE 898
+ V+E I L + P ++ N E+ I E + + G +L NV+ +
Sbjct: 142 PLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKG---DLYFANVEEK 198
Query: 899 IDSGDYKCVAS---------NSAGKSSHGARVTIDVEKVTFV-----KHLQKSYETEEGK 944
DY C A+ K + + +I K + + S +G+
Sbjct: 199 DSRNDYCCFAAFPRLRTIVQKMPMKLTVNSSNSIKQRKPKLLLPPTESGSESSITILKGE 258
Query: 945 TVILECQTSHTVSTKWYHNKKEISG-MDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKD 1003
++LEC + + NK I G + +E D G +C +
Sbjct: 259 ILLLECFAEGLPTPQVDWNK--IGGDLPKGREAKENYGKTLKIENVSYQDKGNYRCTASN 316
Query: 1004 ---QETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEII--K 1057
T V+ E P + +K Q IL E E + W +G +
Sbjct: 317 FLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNH 376
Query: 1058 PKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITR-LQNQ 1116
P F + L +T+V+ + E S + A + VV++ P I T+ +N
Sbjct: 377 PFAGDVVFPREISFTNLQPNHTAVY-QCEASNVHGTILANANIDVVDVRPLIQTKDGENY 435
Query: 1117 KVNKGNKATFEIE-LTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGE 1175
G A E +A+V W K E++ + I + L+I +DAG
Sbjct: 436 ATVVGYSAFLHCEFFASPEAVVSWQK-VEEVKPLEGRRYHI-YENGTLQINRTTEEDAGS 493
Query: 1176 YSCEVGNSKCTAILTVEEPSINFTL--------RLPEFILVPANTDAYLTVEIPDETLDV 1227
YSC V N+ +T N T R+P+ ++ + ++ + +L +
Sbjct: 494 YSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHL-KHSLKL 552
Query: 1228 TWYKKKSVIE--DTEKFTLISDVKKRTLIIRKCTEDDQCEYTC----VLLDAKSTTKLKV 1281
+W K E TE +I D L I T +DQ Y C L A T++ V
Sbjct: 553 SWSKDGEAFEINGTEDGRIIID--GANLTISNVTLEDQGIYCCSAHTALDSAADITQVTV 610
Query: 1282 EVVEFPPKIVDY-EREYRIKR 1301
V PP+ + ER+ R R
Sbjct: 611 LDVPDPPENLHLSERQNRSVR 631
Score = 37.1 bits (82), Expect = 0.69
Identities = 29/130 (22%), Positives = 49/130 (37%), Gaps = 3/130 (2%)
Query: 1251 RTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLV 1309
+TL I + D+ Y C + T V VE PP+ + GS+ LL
Sbjct: 295 KTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLC 354
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
+ + PQP +W VN + + + S T ++ +Y+ N G
Sbjct: 355 EAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFT--NLQPNHTAVYQCEASNVHGTI 412
Query: 1370 DVEMNVTILD 1379
N+ ++D
Sbjct: 413 LANANIDVVD 422
Score = 36.3 bits (80), Expect = 1.2
Identities = 56/249 (22%), Positives = 91/249 (36%), Gaps = 17/249 (6%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAI----LTVE 1192
V W K G ++ + + + LKI + D G Y C N TA + VE
Sbjct: 274 VDWNKIGGDLPKGREAK---ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVE 330
Query: 1193 EPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVK-KR 1251
EP +T + P+ + ++ L E E ++ D F DV R
Sbjct: 331 EPP-RWT-KKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFA--GDVVFPR 386
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKST--TKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLL 1308
+ + Y C + T ++VV+ P I + E Y G L
Sbjct: 387 EISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLH 446
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
++ A P+ W + +K + + I ++ +L I + DAG Y +EN G
Sbjct: 447 CEFFASPEAVVSW-QKVEEVKPLEGRRYHI-YENGTLQINRTTEEDAGSYSCWVENAIGK 504
Query: 1369 ADVEMNVTI 1377
V N+ I
Sbjct: 505 TAVTANLDI 513
Score = 35.1 bits (77), Expect = 2.8
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + C+ P ++W ++ +KP + + Y+ +N TL I EDAG+++C
Sbjct: 440 GYSAFLHCEFFASPEAVVSW-QKVEEVKPLEG-RRYHIYEN-GTLQINRTTEEDAGSYSC 496
Query: 584 VAKNAAGFASSTTEL 598
+NA G + T L
Sbjct: 497 WVENAIGKTAVTANL 511
>BC008124-1|AAH08124.2| 294|Homo sapiens NFASC protein protein.
Length = 294
Score = 87.0 bits (206), Expect = 7e-16
Identities = 62/230 (26%), Positives = 106/230 (46%), Gaps = 13/230 (5%)
Query: 732 KEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITI 791
K P ++ K++I+ GE L + GNP+PT+ W N +P+++ P + + TI
Sbjct: 9 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 68
Query: 792 L-KPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTI 850
+ + ++ VY N G +A ++V + P + R Q I V
Sbjct: 69 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD-----VPPRMLSPRNQLIRVILYNRT 123
Query: 851 KLVARVTRNPVPSITWYRNNEIISPSETITQNFD-GENIELVITNVDSEIDSGDYKCVAS 909
+L +P+P++ W++N + S N+ EN L I + E D G Y CVA+
Sbjct: 124 RLDCPFFGSPIPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKE-DQGIYTCVAT 179
Query: 910 NSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK 959
N GK+ + +V ++V+ T + + + G TV LEC+ H S K
Sbjct: 180 NILGKAEN--QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLK 227
Score = 67.7 bits (158), Expect = 4e-10
Identities = 75/297 (25%), Positives = 120/297 (40%), Gaps = 31/297 (10%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIV---PDENISVAIESDMHM 690
P + +PK + G D L CR P+P + W+ GE + P+ N VA ++
Sbjct: 12 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT---- 67
Query: 691 YCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQG 749
+ + T + Y N G + + PP+++ P +I V
Sbjct: 68 --IIFRDTQISS--RAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLSPRNQLIRVILY 120
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
L G+P PT+ W KN + + +K + +D+G+YT A N
Sbjct: 121 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 180
Query: 810 SEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGT-IKLVARVTRNPVPSIT--W 866
G AE + V++PT I R E V +GT ++L RV +P +T W
Sbjct: 181 ILGKAENQVRLEVKDPTR--------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW 232
Query: 867 YRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+++E + I E+ L I V +E D G Y CVAS + A +T+
Sbjct: 233 LKDDEPLY----IGNRMKKEDDSLTIFGV-AERDQGSYTCVASTELDQDLAKAYLTV 284
Score = 62.1 bits (144), Expect = 2e-08
Identities = 54/224 (24%), Positives = 91/224 (40%), Gaps = 8/224 (3%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXX---XXXXXXXX 1545
KN+ P ED L C G P+P V W +G+ L++A
Sbjct: 19 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 78
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C N+HG + + V + P +S + + + + + G P P +
Sbjct: 79 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 138
Query: 1606 WYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDK 1665
W+KNG D N E S + IK +++ YT A+N G + +V L+V D
Sbjct: 139 WFKNGQGSNLDGG-NYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 196
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPL-DDGGLELTKYAIEKHEP 1708
P +++R T++ + + D L+LT ++ EP
Sbjct: 197 TRIYRMP--EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 238
Score = 39.1 bits (87), Expect = 0.17
Identities = 24/76 (31%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Query: 528 QFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKN 587
+ +C G P P + WF+ + D Y+ +N +L I+ + ED G +TCVA N
Sbjct: 124 RLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYEN-GSLEIKMIRKEDQGIYTCVATN 180
Query: 588 AAGFASSTTELIVEAP 603
G A + L V+ P
Sbjct: 181 ILGKAENQVRLEVKDP 196
>AK074083-1|BAB84909.1| 1471|Homo sapiens FLJ00154 protein protein.
Length = 1471
Score = 87.0 bits (206), Expect = 7e-16
Identities = 107/468 (22%), Positives = 180/468 (38%), Gaps = 30/468 (6%)
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEG----PVI 1674
Y + ++ I L ++ ++ N G S + +V P V
Sbjct: 400 YEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVT 459
Query: 1675 MREISRESVTIEWKPPLD---DGGLELTKYAIEKHEPDNNRWIKVADV--DRDVETYCIQ 1729
+R S S+ + W P D +G E Y I+ D VA V DR + I+
Sbjct: 460 VRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQS-SAVAQVVSDRLEREFTIE 518
Query: 1730 KLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWF 1789
+L E EY ++ A N VG SE + +T VPS + + + +TW
Sbjct: 519 ELEEWMEYELQMQAFNAVGAGPW--SEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWT 576
Query: 1790 P-SEKNGGSPIIDYKVEIKQEG----KKWKXXXXXXXXXARIQKLSINTTYQFRIYARNE 1844
E++ I+ YK+ + + + A + L Y+ ++ A
Sbjct: 577 SVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTR 636
Query: 1845 IGTSLPYTSDDKITIGKTLTP-PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
IG +P T + + +T P P V E SV + W PE G I Y I
Sbjct: 637 IGNGVPSTP---LILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGI-ILGYQIA 692
Query: 1904 FKTVKGKSWT-KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKH 1962
++ T V VG +V + ++ + IFR+SA+ G P E+ + EK
Sbjct: 693 YRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKR 752
Query: 1963 ATVPSPPTAPLEIRM-VGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEV-GKVD 2020
P+PP L + V + + W P DG +P+ + + +R++ + W +
Sbjct: 753 ER-PAPPRELLVPQAEVTARSLRLQW-VPGSDGASPIRYFTMQVRELPRGEWQTYSSSIS 810
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIG---LSEPLESDEPFKVIPGE 2065
+ L +Y +R+ A N+IG S E+ + +PGE
Sbjct: 811 HEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGE 858
Score = 74.9 bits (176), Expect = 3e-12
Identities = 103/457 (22%), Positives = 178/457 (38%), Gaps = 37/457 (8%)
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG----TSSVEVTLKVYDKPSKPEGPVI 1674
Y+ + + + + L+ S K ++A+N G +S E + D P +P G V
Sbjct: 805 YSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVS 864
Query: 1675 MREISRESVTIEWKPPLDD---GGLELTKYAIEKHEPDNNRWIKVADVDRDVETYC-IQK 1730
+ SV I+W+PP D+ G L+ + + E + + + + +
Sbjct: 865 ATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALRAELTD 924
Query: 1731 LNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWF- 1789
L + Y + A N +G S A S P+ + P+ + + +TW
Sbjct: 925 LKKYRRYEVIMTAYNIIGESPA--SAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDP 982
Query: 1790 --PSEKNG---GSPIIDYKVEIKQEGKKWKXXXXXXXXXARIQKLSINTTYQFRIYARNE 1844
P +NG G I ++ + + E +K K R++ L+ +T Y I A N
Sbjct: 983 PPPESQNGNIQGYKIYYWEADSQNETEKMK-VLFLPEPVVRLKNLTSHTKYLVSISAFNA 1041
Query: 1845 IGTSLPYTSDDKITIGKT-LTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
G P + + G+T P P SE TS ++ + W EP + G + Y +
Sbjct: 1042 AGDG-PKSDPQQ---GRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGI-LQGYRVV 1096
Query: 1904 FK---TVKGKSWTKIVTVGGSVHEHC-IENIKEKDEIIFRISAEN-TVGVSLPTESQSVR 1958
++ V+G S V V G+ + ++ + FR+ A T G L +
Sbjct: 1097 YEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGP 1156
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMW-MEVG 2017
E P +P ++ + S +T T G P GY I R + +W M V
Sbjct: 1157 AE------GSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVK 1210
Query: 2018 KV--DVNTLKFNIRDLSENHTYMIRIYARNEIGLSEP 2052
+ + ++ L + TY R+ A NE G EP
Sbjct: 1211 DIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEP 1247
Score = 58.4 bits (135), Expect = 3e-07
Identities = 92/402 (22%), Positives = 153/402 (38%), Gaps = 30/402 (7%)
Query: 1666 PSKPEGPVIMREISRESVTIEWKPPLDD--GGLELTKYAIEKHEPDNNRWIKVADVDRD- 1722
P+ P V ++ ++ W PP G+ Y + D + V + D
Sbjct: 147 PTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGIN-QGYKLLAWPADAPEAVTVVTIAPDF 205
Query: 1723 --VETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXID 1780
V I L + Y V+ G + S P ++ T D P +D
Sbjct: 206 HGVHHGHITNLKKFTAYFTSVLCFTTPG--DGPPSTPQLVWTQEDKPGAVGHLSFTEILD 263
Query: 1781 NESVYITWF-PSEKNGGSPIIDYKVEIKQEGK---KWKXXXXXXXXXARIQKLSINTTYQ 1836
S+ ++W P EKNG I Y++ + G+ + +IQ LS TTY
Sbjct: 264 T-SLKVSWQEPLEKNG--IITGYQISWEVYGRNNSRLTHTLNSTTHEYKIQGLSSLTTYT 320
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
+ A +GT L +S I+ G P P N V+S + RS TL++ P +G +
Sbjct: 321 IDVAAVTAVGTGLVTSST--ISSGVPPDLPGAPSNLVISNISPRSATLQF-RPGYDGKTS 377
Query: 1897 ITNYIIEFKT---VKGKSWTKIVTVGGSVHEHCIE--NIKEKDEIIFRISAENTVGVSLP 1951
I+ +I+E + + W + +E N+ FR+ N VG S
Sbjct: 378 ISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPY 437
Query: 1952 TESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSW---GTPEWDGGAPLLGYNIAI--R 2006
+ S V A PT+ + +R + W +++G +GY I
Sbjct: 438 SPSSRVIQTLQAPPDVAPTS-VTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRS 496
Query: 2007 DVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
D+ + +V D +F I +L E Y +++ A N +G
Sbjct: 497 DLQSSAVAQVVS-DRLEREFTIEELEEWMEYELQMQAFNAVG 537
Score = 51.6 bits (118), Expect = 3e-05
Identities = 115/538 (21%), Positives = 202/538 (37%), Gaps = 57/538 (10%)
Query: 1355 AGIYKLRLENNCGHAD-VEMNVTILDKPSPPGKPNIL-----EIDSSSINICWDEPENTG 1408
A I++L + G + +E V +K P P L E+ + S+ + W P + G
Sbjct: 725 AYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQW-VPGSDG 783
Query: 1409 NSTIIYYVVEYQEIDTTEWISVKN-ITKTQTS--IQNLKTNSSYRFRAYAVNEVDISDAS 1465
S I Y+ ++ +E+ EW + + I+ T+ + L+ +SY+ R A N++ SD S
Sbjct: 784 ASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFS 843
Query: 1466 ETTEYYKVIKETKIQSPTVEKPLKNITT------EPNEDIELTCIFGGVP-QPKVTWYRD 1518
TE +++ + P + T+ +P D L + G + Y
Sbjct: 844 SETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEA 903
Query: 1519 GKKLKTAKATYENRXXXXXXXXXXXXXXXYKCI--AFNDHGEVETSCVVGI-QQKPVITI 1575
G T T +N Y+ I A+N GE S V + + +
Sbjct: 904 GS--GTEAKTLKNPIALRAELTDLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAM 961
Query: 1576 SNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEY-------NITTKEKT- 1627
+ ++++ + VT PPPE +NGN ++ K Y N T K K
Sbjct: 962 APQNVQVTPLTASQLEVT---WDPPPPE---SQNGN-IQGYKIYYWEADSQNETEKMKVL 1014
Query: 1628 ----SVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGP--VIMREISRE 1681
V+R+K L +I A N AG + + P P + EI+
Sbjct: 1015 FLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITST 1074
Query: 1682 SVTIEW-KPPLDDGGLELTKYAIEKHEP-DNNRWIKVADVDRDVETYC-IQKLNENCEYM 1738
++ + W +P +G L+ + E P + +V + + + ++ L + Y
Sbjct: 1075 TLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYF 1134
Query: 1739 FRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSP 1798
FRV A+ + + L++ I A P + + W +G +P
Sbjct: 1135 FRVQART-ITYGPELQAN-ITAGPAEGSPGSPRDVLVTKSA--SELTLQWTEGH-SGDTP 1189
Query: 1799 IIDYKVEIKQEGK-KWKXX-----XXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
Y +E + + W + KL TY+FR+ A NE G P
Sbjct: 1190 TTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEP 1247
Score = 50.4 bits (115), Expect = 7e-05
Identities = 38/160 (23%), Positives = 74/160 (46%), Gaps = 7/160 (4%)
Query: 1834 TYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKW-TEPESN 1892
TYQFR+ A NE+G Y+++ + P + P+N V S T++S+ ++W PE+
Sbjct: 16 TYQFRVCAVNEVGRG-QYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETE 74
Query: 1893 GGSPITNYIIEFKT--VKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSL 1950
+ YI+ ++ + G+ + +T V+ + ++ + +++A N G L
Sbjct: 75 HNGVLRGYILRYRLAGLPGEYQQRNIT-SPEVNYCLVTDLIIWTQYEIQVAAYN--GAGL 131
Query: 1951 PTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTP 1990
S++V VP+ P ++ V S + W P
Sbjct: 132 GVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPP 171
Score = 41.5 bits (93), Expect = 0.032
Identities = 28/103 (27%), Positives = 51/103 (49%), Gaps = 8/103 (7%)
Query: 1370 DVEMNVTILDKPSPPGKPN--ILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW 1427
+++ N+T PG P ++ +S + + W E ++G++ YV+E + D W
Sbjct: 1147 ELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEG-HSGDTPTTGYVIEARPSDEGLW 1205
Query: 1428 -ISVKNITKTQTS----IQNLKTNSSYRFRAYAVNEVDISDAS 1465
+ VK+I ++ TS + L+ +Y FR AVNE + S
Sbjct: 1206 DMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPS 1248
>AF002246-1|AAB60937.1| 1224|Homo sapiens neural cell adhesion
molecule protein.
Length = 1224
Score = 87.0 bits (206), Expect = 7e-16
Identities = 177/833 (21%), Positives = 311/833 (37%), Gaps = 57/833 (6%)
Query: 1261 DDQCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDE 1320
+D T + A S + K +++ PP E I +G + L + P P +
Sbjct: 231 NDSSSSTEIGSKANSIKQRKPKLL-LPPTESGSESSITILKGEILLLECFAEGLPTPQVD 289
Query: 1321 WIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK 1380
W + K + K ++ +L I+ V D G Y+ N G A + +V + +
Sbjct: 290 WNKIGGDLPKGREAK---ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEP 346
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSI 1440
P KP + S I E E T I + V +D + + + S
Sbjct: 347 PRWTKKPQSAVYSTGSNGILLCEAEGEPQPT-IKWRVNGSPVDNHPFAG-DVVFPREISF 404
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
NL+ N + AV + + S+ T I ++ K +N T
Sbjct: 405 TNLQPNHT------AVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAF 458
Query: 1501 LTCIFGGVPQPKVTWYR--DGKKLKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L C F P+ V+W + + K L+ + Y C N G+
Sbjct: 459 LHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGK 518
Query: 1559 VETSCVVGIQQKPVITIS--NEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
+ + I+ + +S N I + H + ++ W K+G E +
Sbjct: 519 TAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEIN 578
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVT-LKVYDKPSKPEGPVIM 1675
+ + + I + Y A +TA S+ ++T + V D P PE + +
Sbjct: 579 GTEDGRIIIDGANLTISNVTLEDQGIYCCSA-HTALDSAADITQVTVLDVPDPPEN-LHL 636
Query: 1676 REISRESVTIEWKPPLDDGGLELTKYAIE----KHEPDNNRWIKVADVDRDVETYCIQKL 1731
E SV + W+ D +++Y +E K EP RW ++ V + +T I L
Sbjct: 637 SERQNRSVRLTWEAGADHNS-NISEYIVEFEGNKEEP--GRWEELTRV-QGKKTTVILPL 692
Query: 1732 NENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFP- 1790
Y FRVIA N VG S+ + +T P + + I W P
Sbjct: 693 APFVRYQFRVIAVNEVGRSQPSQPSD-HHETPPAAPDRNPQNIRVQASQPKEMIIKWEPL 751
Query: 1791 --SEKNGGSPIIDYKVEIKQEGK--KWKXXXXXXXXXARIQKLSINTTYQFRIYARNEIG 1846
E+NG P ++Y+V K +G +W+ R+ ++ Y ++ A N++G
Sbjct: 752 KSMEQNG--PGLEYRVTWKPQGAPVEWE-EETVTNHTLRVMTPAVYAPYDVKVQAINQLG 808
Query: 1847 TSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKW-TEPESNGGSPITNYIIE-F 1904
+ P + G+ P + P V S V + W T P+ + Y I +
Sbjct: 809 SG-PDPQSVTLYSGEDY-PDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWW 866
Query: 1905 KT---VKGKSWTKIVTV---GGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
KT + G++ K V + G + + ++ E + A N+ G ES+
Sbjct: 867 KTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAG--PESEPYI 924
Query: 1959 LEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM-EVG 2017
+ VP PT L++ V + SWG P+ G L GY + + + T + E+
Sbjct: 925 FQTPEGVPEQPTF-LKVIKVDKDTATLSWGLPKKLNG-NLTGYLLQYQIINDTYEIGELN 982
Query: 2018 KVDVNT---LKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGS 2067
+++ T +++ +L+ Y + A G +P+ + GEGS
Sbjct: 983 DINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESS---TLGEGS 1032
Score = 77.0 bits (181), Expect = 7e-13
Identities = 93/360 (25%), Positives = 148/360 (41%), Gaps = 37/360 (10%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+PPT S + + +G +LLEC +P P + W G ++ A E+ Y
Sbjct: 255 LPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRE---AKEN----Y 307
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGES 751
LKI NV +G Y A N G A+ + ++ EPP+ + +S + G +
Sbjct: 308 GKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVE----EPPRWTKKPQSAVYSTGSN 363
Query: 752 VILSAQVVGNPRPTITWCKNNKPVKALPTKSD---GDTHSITILKPKKVKDEGVYTLKAE 808
IL + G P+PTI W N PV P D S T L+P VY +A
Sbjct: 364 GILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHT---AVYQCEAS 420
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG-TIKLVARVTRNPVPSITWY 867
N G +A I V + PL + E G + L +P ++W
Sbjct: 421 NVHGTILANANIDVVDVR------PLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQ 474
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
+ E + P E + EN L I N +E D+G Y C N+ GK++ +D+
Sbjct: 475 KVEE-VKPLEGRRYHI-YENGTLQI-NRTTEEDAGSYSCWVENAIGKTA--VTANLDIRN 529
Query: 928 VTFVKHLQKSYETEEGKTVILECQT------SHTVSTKWYHNKK--EISGMDHREIIQEG 979
T ++ K+ + + L C++ H++ W + + EI+G + II +G
Sbjct: 530 ATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDG 589
Score = 58.0 bits (134), Expect = 3e-07
Identities = 53/252 (21%), Positives = 91/252 (36%), Gaps = 6/252 (2%)
Query: 1415 YVVEYQEIDT-TEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKV 1473
Y +E D+ ++ + +T +Q + + +A + ++ K
Sbjct: 189 YFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQ 248
Query: 1474 IKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-R 1532
K + PT +IT E + L C G+P P+V W + G L + EN
Sbjct: 249 RKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGREAKENYG 308
Query: 1533 XXXXXXXXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLV 1592
Y+C A N G V +++ P T + + G ++
Sbjct: 309 KTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWT--KKPQSAVYSTGSNGIL 366
Query: 1593 TAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
EG P P + W NG+ ++N + I L+ +H++ Y EASN G
Sbjct: 367 LCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPRE--ISFTNLQPNHTAVYQCEASNVHG 424
Query: 1653 TSSVEVTLKVYD 1664
T + V D
Sbjct: 425 TILANANIDVVD 436
Score = 50.0 bits (114), Expect = 9e-05
Identities = 86/366 (23%), Positives = 139/366 (37%), Gaps = 33/366 (9%)
Query: 832 PPLFINRFQEITVKEKGTIKLVARVTRN-PVPSITWYRNNEIISPSETITQNFDGENIEL 890
PP IT+ KG I L+ P P + W + + +N+ G+ ++
Sbjct: 256 PPTESGSESSITIL-KGEILLLECFAEGLPTPQVDWNKIGGDLPKGREAKENY-GKTLK- 312
Query: 891 VITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKS-YETEEGKTVILE 949
I NV + D G+Y+C ASN G ++H V ++ E + K Q + Y T ++ E
Sbjct: 313 -IENVSYQ-DKGNYRCTASNFLGTATHDFHVIVE-EPPRWTKKPQSAVYSTGSNGILLCE 369
Query: 950 CQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKCIVKDQETSTM 1009
+ + KW N + + R V +C + + +
Sbjct: 370 AEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFTNLQPNHT--AVYQCEASNVHGTIL 427
Query: 1010 LVVKETIPEFIRKLQ--DFEVKEKDV---AILEVEI-NSETADVVWERDGEIIKPKKNKY 1063
+ + +Q D E V A L E S A V W++ E+ + +Y
Sbjct: 428 ANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRY 487
Query: 1064 DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNK 1123
+ G L I T+ D G YSC + + VT L T+L+ N
Sbjct: 488 HIYENG---TLQINRTTEEDAGSYSCWVENAIGKTAVT-ANLDIRNATKLRVSPKNPRIP 543
Query: 1124 ATFEIEL---TKGDALVR------WFKDGS--EIQFSNHIQLTIDGKKQKLKIYDCDLDD 1172
+EL +K D+ ++ W KDG EI + ++ IDG L I + L+D
Sbjct: 544 KLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDG--ANLTISNVTLED 601
Query: 1173 AGEYSC 1178
G Y C
Sbjct: 602 QGIYCC 607
Score = 44.0 bits (99), Expect = 0.006
Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC EG P PQ+ W + + ++ + Y TL I V +D G + C
Sbjct: 271 GEILLLECFAEGLPTPQVDWNKIGGDLPKGREAKENYGK----TLKIENVSYQDKGNYRC 326
Query: 584 VAKNAAGFASSTTELIVEAP 603
A N G A+ +IVE P
Sbjct: 327 TASNFLGTATHDFHVIVEEP 346
Score = 37.1 bits (82), Expect = 0.69
Identities = 29/130 (22%), Positives = 49/130 (37%), Gaps = 3/130 (2%)
Query: 1251 RTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYEREYRIKRGSDVTLLV 1309
+TL I + D+ Y C + T V VE PP+ + GS+ LL
Sbjct: 309 KTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLC 368
Query: 1310 DYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
+ + PQP +W VN + + + S T ++ +Y+ N G
Sbjct: 369 EAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISFT--NLQPNHTAVYQCEASNVHGTI 426
Query: 1370 DVEMNVTILD 1379
N+ ++D
Sbjct: 427 LANANIDVVD 436
Score = 36.7 bits (81), Expect = 0.91
Identities = 40/191 (20%), Positives = 74/191 (38%), Gaps = 14/191 (7%)
Query: 725 LKIKTGEKEPPQVIEPLKSMIVRQGESVI-LSAQVVGNPRPTITWCKNNKPVKALPTKSD 783
++I + ++ P +I+ K + + + + GNP PT +W K+ P +
Sbjct: 25 IEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRII 84
Query: 784 GDTHSITILKPKK---VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQ 840
+S T P + +G Y A N GIA + + + + P +
Sbjct: 85 PSNNSGTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVP-----SVPKFPKEKID 139
Query: 841 EITVKEKGTIKLVARVTRNPVPSITWYRNNEI--ISPSETITQNFDGENIELVITNVDSE 898
+ V+E I L + P ++ N E+ I E + + G +L NV+ +
Sbjct: 140 PLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKG---DLYFANVEEK 196
Query: 899 IDSGDYKCVAS 909
DY C A+
Sbjct: 197 DSRNDYCCFAA 207
Score = 36.3 bits (80), Expect = 1.2
Identities = 56/249 (22%), Positives = 91/249 (36%), Gaps = 17/249 (6%)
Query: 1137 VRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAI----LTVE 1192
V W K G ++ + + + LKI + D G Y C N TA + VE
Sbjct: 288 VDWNKIGGDLPKGREAK---ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVE 344
Query: 1193 EPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVK-KR 1251
EP +T + P+ + ++ L E E ++ D F DV R
Sbjct: 345 EPP-RWT-KKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFA--GDVVFPR 400
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKST--TKLKVEVVEFPPKIVDYERE-YRIKRGSDVTLL 1308
+ + Y C + T ++VV+ P I + E Y G L
Sbjct: 401 EISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLH 460
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGH 1368
++ A P+ W + +K + + I ++ +L I + DAG Y +EN G
Sbjct: 461 CEFFASPEAVVSW-QKVEEVKPLEGRRYHI-YENGTLQINRTTEEDAGSYSCWVENAIGK 518
Query: 1369 ADVEMNVTI 1377
V N+ I
Sbjct: 519 TAVTANLDI 527
Score = 35.1 bits (77), Expect = 2.8
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + C+ P ++W ++ +KP + + Y+ +N TL I EDAG+++C
Sbjct: 454 GYSAFLHCEFFASPEAVVSW-QKVEEVKPLEG-RRYHIYEN-GTLQINRTTEEDAGSYSC 510
Query: 584 VAKNAAGFASSTTEL 598
+NA G + T L
Sbjct: 511 WVENAIGKTAVTANL 525
>D86983-1|BAA13219.1| 1496|Homo sapiens KIAA0230 protein.
Length = 1496
Score = 86.6 bits (205), Expect = 9e-16
Identities = 95/391 (24%), Positives = 152/391 (38%), Gaps = 29/391 (7%)
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P E N E P + Q+ V T+ R NP P I W RNN +S N
Sbjct: 255 PEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLL 314
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI----DVEKVTFVKHLQKSYET 940
+ L+I N E D G Y+C+A N AG+ VT+ + TFV Q + E
Sbjct: 315 DDG-TLMIQNT-QETDQGIYQCMAKNVAGEVK-TQEVTLRYFGSPARPTFVIQPQNT-EV 370
Query: 941 EEGKTVILECQ-TSH-TVSTKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVI 997
G++V LEC T H W + +D R I G +
Sbjct: 371 LVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACS 430
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEII 1056
D +T ++ + +P+F QD V E + E V+ W + G +
Sbjct: 431 ATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL 490
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC----ILRDESCTAEVTV-VELPPEIIT 1111
+ ++ G +R I ++HD+G+Y C I+ + A +TV + P +
Sbjct: 491 SVDR-RHLVLSSGTLR---ISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 546
Query: 1112 RLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
+ V G + + + W KDG ++ S ++ +G L I D
Sbjct: 547 IPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG---FLTINDVGP 603
Query: 1171 DDAGEYSC----EVGNSKCTAILTVEEPSIN 1197
DAG Y C +G++ + +L+V P ++
Sbjct: 604 ADAGRYECVARNTIGSASVSMVLSVNVPDVS 634
Score = 86.2 bits (204), Expect = 1e-15
Identities = 94/417 (22%), Positives = 155/417 (37%), Gaps = 29/417 (6%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P + +P+ V G+ + CR P+P+I WL E+ + + + D
Sbjct: 263 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDD-----G 317
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLP-IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N ++ +G Y +A N GE + L+ P VI+P + ++ GESV
Sbjct: 318 TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVL-VGESV 376
Query: 753 ILSAQVVGNPRPTITWCKNNK-PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
L G+P P I+W + ++ P+ P + + + I + D G Y A N+
Sbjct: 377 TLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ-GDSGEYACSATNNI 435
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+A I V+ + P Q+ V E T+ NP P I W +
Sbjct: 436 DSVHATAFIIVQALPQFTVTP-------QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGS 488
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV 931
+S G L I+ V D G Y+C A N G A +T+
Sbjct: 489 QLSVDRRHLVLSSG---TLRISGVALH-DQGQYECQAVNIIGSQKVVAHLTVQPRVTPVF 544
Query: 932 KHLQKSYETEEGKTVILEC--QTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ E G V L C Q + W + +++ I EG
Sbjct: 545 ASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG---FLTINDV 601
Query: 990 XXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRKLQDFEVKE--KDVAILEVEINS 1042
D G +C+ ++ S +V+ +P+ R F + +A ++ INS
Sbjct: 602 GPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINS 658
Score = 72.9 bits (171), Expect = 1e-11
Identities = 91/386 (23%), Positives = 154/386 (39%), Gaps = 36/386 (9%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI--- 789
E P++ + V G +V + + GNP+P I W +NN L K+D + +
Sbjct: 261 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNN---NELSMKTDSRLNLLDDG 317
Query: 790 -TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+++ + D+G+Y A+N G +T V T+ + P F+ + Q V
Sbjct: 318 TLMIQNTQETDQGIYQCMAKNVAGEVKTQEV-TLR--YFGSPARPTFVIQPQNTEVLVGE 374
Query: 849 TIKLVARVTRNPVPSITWYRNNEI---ISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
++ L T +P P I+W R + + P IT + G I+ V+ DSG+Y
Sbjct: 375 SVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPS-GGLYIQNVVQG-----DSGEYA 428
Query: 906 CVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHN 963
C A+N+ S H A I V+ + + EG+TV +C+ W
Sbjct: 429 CSATNNI-DSVH-ATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG 486
Query: 964 KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETSTMLVVKETI-PE 1018
++S +D R ++ D G +C I+ Q+ L V+ + P
Sbjct: 487 GSQLS-VDRRHLVLS--SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV 543
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
F D V+ L E + W +DG + + K+ G L I
Sbjct: 544 FASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG-VQVTESGKFHISPEGF---LTIN 599
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVV 1103
+ D G Y C+ R+ +A V++V
Sbjct: 600 DVGPADAGRYECVARNTIGSASVSMV 625
Score = 62.9 bits (146), Expect = 1e-08
Identities = 77/320 (24%), Positives = 129/320 (40%), Gaps = 26/320 (8%)
Query: 1074 LYIRNTSVHDEGEYSCILRD---ESCTAEVTV----VELPPEIITRLQNQKVNKGNKATF 1126
L I+NT D+G Y C+ ++ E T EVT+ P + + QN +V G T
Sbjct: 319 LMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTL 378
Query: 1127 EIELT-KGDALVRWFK-DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS- 1183
E T + W + D + + + +T G L I + D+GEY+C N+
Sbjct: 379 ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG---LYIQNVVQGDSGEYACSATNNI 435
Query: 1184 ---KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE 1240
TA + V+ FT+ + +++ T + + + W K S +
Sbjct: 436 DSVHATAFIIVQALP-QFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR 494
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP---PKIVDYEREY 1297
+ ++S TL I DQ +Y C ++ + K+ + P P +
Sbjct: 495 RHLVLSS---GTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 551
Query: 1298 RIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGI 1357
++ G++V L Q P+P W N ++ + K I S LTI V DAG
Sbjct: 552 TVEVGANVQLPCSSQGEPEPAITW--NKDGVQVTESGKFHI-SPEGFLTINDVGPADAGR 608
Query: 1358 YKLRLENNCGHADVEMNVTI 1377
Y+ N G A V M +++
Sbjct: 609 YECVARNTIGSASVSMVLSV 628
Score = 58.0 bits (134), Expect = 3e-07
Identities = 77/428 (17%), Positives = 159/428 (37%), Gaps = 18/428 (4%)
Query: 1264 CEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
CEY + T E+ P+I ++ + G+ V + P+P W+
Sbjct: 239 CEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR 298
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
N+ + ++ ++ +L I+ + TD GIY+ +N G + VT+ SP
Sbjct: 299 NNNELSMKTDSRLNL-LDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQ-EVTLRYFGSP 356
Query: 1384 PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS---I 1440
+++ ++ + + + + + D T + T + I
Sbjct: 357 ARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYI 416
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
QN+ S + A N +D A+ +I + Q P + E + ++
Sbjct: 417 QNVVQGDSGEYACSATNNIDSVHATAF-----IIVQALPQFTVT--PQDRVVIE-GQTVD 468
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
C G P P + W + G +L + + Y+C A N G
Sbjct: 469 FQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQ 528
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
+ + +Q + ++ +VG + +G P P + W K+G ++ ++
Sbjct: 529 KVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKF 588
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV-YDKPSKPEGPVIMREI 1678
+I+ + + I ++ + + +Y A NT G++SV + L V S+ P + I
Sbjct: 589 HISPE---GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSI 645
Query: 1679 SRESVTIE 1686
T++
Sbjct: 646 VEAIATVD 653
Score = 54.8 bits (126), Expect = 3e-06
Identities = 26/67 (38%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV F C+ EG P+P+I W R + D ++ DD TL+I+ D G + C
Sbjct: 277 GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDD--GTLMIQNTQETDQGIYQC 334
Query: 584 VAKNAAG 590
+AKN AG
Sbjct: 335 MAKNVAG 341
Score = 53.6 bits (123), Expect = 7e-06
Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 508 MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
+ P+F G+ VQ C +G P P ITW + + S F + +
Sbjct: 540 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPE----GF 595
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
L I +V P DAG + CVA+N G AS + L V P
Sbjct: 596 LTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 631
Score = 41.5 bits (93), Expect = 0.032
Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P F+ P V+ G+++ L C PEP I W G ++ ++ E
Sbjct: 540 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPE------ 593
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L I +V G Y VA N G AS+ +VL +
Sbjct: 594 -GFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 628
Score = 38.3 bits (85), Expect = 0.30
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 3/93 (3%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P FV + + G +V EC G+P P+I+W R P D ++ L
Sbjct: 359 PTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLP-VDPRVNITPS--GGLY 415
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
I+ V D+G + C A N +T +IV+A
Sbjct: 416 IQNVVQGDSGEYACSATNNIDSVHATAFIIVQA 448
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/79 (27%), Positives = 34/79 (43%), Gaps = 4/79 (5%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G TV F+C+ +G P P I W + + + + + + TL I V D G +
Sbjct: 463 EGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVL----SSGTLRISGVALHDQGQYE 518
Query: 583 CVAKNAAGFASSTTELIVE 601
C A N G L V+
Sbjct: 519 CQAVNIIGSQKVVAHLTVQ 537
>BC098579-1|AAH98579.1| 722|Homo sapiens PXDN protein protein.
Length = 722
Score = 86.6 bits (205), Expect = 9e-16
Identities = 95/391 (24%), Positives = 152/391 (38%), Gaps = 29/391 (7%)
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P E N E P + Q+ V T+ R NP P I W RNN +S N
Sbjct: 233 PEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLL 292
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI----DVEKVTFVKHLQKSYET 940
+ L+I N E D G Y+C+A N AG+ VT+ + TFV Q + E
Sbjct: 293 DDG-TLMIQNT-QETDQGIYQCMAKNVAGEVK-TQEVTLRYFGSPARPTFVIQPQNT-EV 348
Query: 941 EEGKTVILECQ-TSH-TVSTKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVI 997
G++V LEC T H W + +D R I G +
Sbjct: 349 LVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACS 408
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEII 1056
D +T ++ + +P+F QD V E + E V+ W + G +
Sbjct: 409 ATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL 468
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC----ILRDESCTAEVTV-VELPPEIIT 1111
+ ++ G +R I ++HD+G+Y C I+ + A +TV + P +
Sbjct: 469 SVDR-RHLVLSSGTLR---ISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 524
Query: 1112 RLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
+ V G + + + W KDG ++ S ++ +G L I D
Sbjct: 525 IPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG---FLTINDVGP 581
Query: 1171 DDAGEYSC----EVGNSKCTAILTVEEPSIN 1197
DAG Y C +G++ + +L+V P ++
Sbjct: 582 ADAGRYECVARNTIGSASVSMVLSVNVPDVS 612
Score = 86.2 bits (204), Expect = 1e-15
Identities = 94/417 (22%), Positives = 155/417 (37%), Gaps = 29/417 (6%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P + +P+ V G+ + CR P+P+I WL E+ + + + D
Sbjct: 241 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDD-----G 295
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLP-IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N ++ +G Y +A N GE + L+ P VI+P + ++ GESV
Sbjct: 296 TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVL-VGESV 354
Query: 753 ILSAQVVGNPRPTITWCKNNK-PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
L G+P P I+W + ++ P+ P + + + I + D G Y A N+
Sbjct: 355 TLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ-GDSGEYACSATNNI 413
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+A I V+ + P Q+ V E T+ NP P I W +
Sbjct: 414 DSVHATAFIIVQALPQFTVTP-------QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGS 466
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV 931
+S G L I+ V D G Y+C A N G A +T+
Sbjct: 467 QLSVDRRHLVLSSG---TLRISGVALH-DQGQYECQAVNIIGSQKVVAHLTVQPRVTPVF 522
Query: 932 KHLQKSYETEEGKTVILEC--QTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ E G V L C Q + W + +++ I EG
Sbjct: 523 ASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG---FLTINDV 579
Query: 990 XXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRKLQDFEVKE--KDVAILEVEINS 1042
D G +C+ ++ S +V+ +P+ R F + +A ++ INS
Sbjct: 580 GPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINS 636
Score = 72.9 bits (171), Expect = 1e-11
Identities = 91/386 (23%), Positives = 154/386 (39%), Gaps = 36/386 (9%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI--- 789
E P++ + V G +V + + GNP+P I W +NN L K+D + +
Sbjct: 239 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNN---NELSMKTDSRLNLLDDG 295
Query: 790 -TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+++ + D+G+Y A+N G +T V T+ + P F+ + Q V
Sbjct: 296 TLMIQNTQETDQGIYQCMAKNVAGEVKTQEV-TLR--YFGSPARPTFVIQPQNTEVLVGE 352
Query: 849 TIKLVARVTRNPVPSITWYRNNEI---ISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
++ L T +P P I+W R + + P IT + G I+ V+ DSG+Y
Sbjct: 353 SVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPS-GGLYIQNVVQG-----DSGEYA 406
Query: 906 CVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHN 963
C A+N+ S H A I V+ + + EG+TV +C+ W
Sbjct: 407 CSATNNI-DSVH-ATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG 464
Query: 964 KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETSTMLVVKETI-PE 1018
++S +D R ++ D G +C I+ Q+ L V+ + P
Sbjct: 465 GSQLS-VDRRHLVLS--SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV 521
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
F D V+ L E + W +DG + + K+ G L I
Sbjct: 522 FASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG-VQVTESGKFHISPEGF---LTIN 577
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVV 1103
+ D G Y C+ R+ +A V++V
Sbjct: 578 DVGPADAGRYECVARNTIGSASVSMV 603
Score = 62.9 bits (146), Expect = 1e-08
Identities = 77/320 (24%), Positives = 129/320 (40%), Gaps = 26/320 (8%)
Query: 1074 LYIRNTSVHDEGEYSCILRD---ESCTAEVTV----VELPPEIITRLQNQKVNKGNKATF 1126
L I+NT D+G Y C+ ++ E T EVT+ P + + QN +V G T
Sbjct: 297 LMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTL 356
Query: 1127 EIELT-KGDALVRWFK-DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS- 1183
E T + W + D + + + +T G L I + D+GEY+C N+
Sbjct: 357 ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG---LYIQNVVQGDSGEYACSATNNI 413
Query: 1184 ---KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE 1240
TA + V+ FT+ + +++ T + + + W K S +
Sbjct: 414 DSVHATAFIIVQALP-QFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR 472
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP---PKIVDYEREY 1297
+ ++S TL I DQ +Y C ++ + K+ + P P +
Sbjct: 473 RHLVLSS---GTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 529
Query: 1298 RIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGI 1357
++ G++V L Q P+P W N ++ + K I S LTI V DAG
Sbjct: 530 TVEVGANVQLPCSSQGEPEPAITW--NKDGVQVTESGKFHI-SPEGFLTINDVGPADAGR 586
Query: 1358 YKLRLENNCGHADVEMNVTI 1377
Y+ N G A V M +++
Sbjct: 587 YECVARNTIGSASVSMVLSV 606
Score = 58.0 bits (134), Expect = 3e-07
Identities = 77/428 (17%), Positives = 159/428 (37%), Gaps = 18/428 (4%)
Query: 1264 CEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
CEY + T E+ P+I ++ + G+ V + P+P W+
Sbjct: 217 CEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR 276
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
N+ + ++ ++ +L I+ + TD GIY+ +N G + VT+ SP
Sbjct: 277 NNNELSMKTDSRLNL-LDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQ-EVTLRYFGSP 334
Query: 1384 PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS---I 1440
+++ ++ + + + + + D T + T + I
Sbjct: 335 ARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYI 394
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
QN+ S + A N +D A+ +I + Q P + E + ++
Sbjct: 395 QNVVQGDSGEYACSATNNIDSVHATAF-----IIVQALPQFTVT--PQDRVVIE-GQTVD 446
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
C G P P + W + G +L + + Y+C A N G
Sbjct: 447 FQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQ 506
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
+ + +Q + ++ +VG + +G P P + W K+G ++ ++
Sbjct: 507 KVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKF 566
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV-YDKPSKPEGPVIMREI 1678
+I+ + + I ++ + + +Y A NT G++SV + L V S+ P + I
Sbjct: 567 HISPE---GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSI 623
Query: 1679 SRESVTIE 1686
T++
Sbjct: 624 VEAIATVD 631
Score = 54.8 bits (126), Expect = 3e-06
Identities = 26/67 (38%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV F C+ EG P+P+I W R + D ++ DD TL+I+ D G + C
Sbjct: 255 GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDD--GTLMIQNTQETDQGIYQC 312
Query: 584 VAKNAAG 590
+AKN AG
Sbjct: 313 MAKNVAG 319
Score = 53.6 bits (123), Expect = 7e-06
Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 508 MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
+ P+F G+ VQ C +G P P ITW + + S F + +
Sbjct: 518 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPE----GF 573
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
L I +V P DAG + CVA+N G AS + L V P
Sbjct: 574 LTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 609
Score = 41.5 bits (93), Expect = 0.032
Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P F+ P V+ G+++ L C PEP I W G ++ ++ E
Sbjct: 518 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPE------ 571
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L I +V G Y VA N G AS+ +VL +
Sbjct: 572 -GFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 606
Score = 38.3 bits (85), Expect = 0.30
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 3/93 (3%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P FV + + G +V EC G+P P+I+W R P D ++ L
Sbjct: 337 PTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLP-VDPRVNITPS--GGLY 393
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
I+ V D+G + C A N +T +IV+A
Sbjct: 394 IQNVVQGDSGEYACSATNNIDSVHATAFIIVQA 426
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/79 (27%), Positives = 34/79 (43%), Gaps = 4/79 (5%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G TV F+C+ +G P P I W + + + + + + TL I V D G +
Sbjct: 441 EGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVL----SSGTLRISGVALHDQGQYE 496
Query: 583 CVAKNAAGFASSTTELIVE 601
C A N G L V+
Sbjct: 497 CQAVNIIGSQKVVAHLTVQ 515
>AK130921-1|BAC85460.1| 572|Homo sapiens protein ( Homo sapiens
cDNA FLJ27411 fis, clone WMC04903, highly similar to
Myosin light chain kinase, smooth muscle and non-muscle
isozymes ).
Length = 572
Score = 86.6 bits (205), Expect = 9e-16
Identities = 41/117 (35%), Positives = 68/117 (58%), Gaps = 1/117 (0%)
Query: 486 KKLNEKIDKLPVFEKPTSEEQS-MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWF 544
+KL + D F + +EE+ + P + +R +GS +F+C++EGYP P++ W
Sbjct: 442 EKLESEEDVSQAFLEAVAEEKPHVKPYLSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWS 501
Query: 545 RQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
+ I+ S+ FQ+ YD+D +L+I +V +D +TC A N+ G A+ T ELIVE
Sbjct: 502 KDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 558
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/101 (27%), Positives = 50/101 (49%), Gaps = 3/101 (2%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P SK + V EGS +C++ P+P++ W + I + + + D +
Sbjct: 465 VKPYLSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWSKDDQSIRESRHFQIDYDEDGN-- 522
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEK 732
CS++ I++V + YT AVN GEA+ L ++T E+
Sbjct: 523 CSLI-ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEE 562
Score = 42.7 bits (96), Expect = 0.014
Identities = 27/121 (22%), Positives = 53/121 (43%), Gaps = 2/121 (1%)
Query: 805 LKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSI 864
L AE E + S E+ P +++ V E + ++ P P +
Sbjct: 439 LNAEKLESEEDVSQAFLEAVAEEKPHVKPYLSKTIRDLEVVEGSAARFDCKIEGYPDPEV 498
Query: 865 TWYRNNEIISPSETITQNFDGE-NIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
W ++++ I S ++D + N L+I++V + D Y C A NS G+++ A + +
Sbjct: 499 VWSKDDQSIRESRHFQIDYDEDGNCSLIISDVCGD-DDAKYTCKAVNSLGEATCTAELIV 557
Query: 924 D 924
+
Sbjct: 558 E 558
Score = 40.3 bits (90), Expect = 0.074
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITI 791
P + + ++ + V +G + ++ G P P + W K+++ ++ D D + I
Sbjct: 467 PYLSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWSKDDQSIRESRHFQIDYDEDGNCSLI 526
Query: 792 LKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAE 831
+ D+ YT KA NS G A +A + VE E E
Sbjct: 527 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGE 566
Score = 39.9 bits (89), Expect = 0.098
Identities = 29/92 (31%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 1107 PEIITRLQNQKVNKGNKATFEIELTK-GDALVRWFKDGSEIQFSNHIQLTIDGKKQ-KLK 1164
P + +++ +V +G+ A F+ ++ D V W KD I+ S H Q+ D L
Sbjct: 467 PYLSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWSKDDQSIRESRHFQIDYDEDGNCSLI 526
Query: 1165 IYDCDLDDAGEYSCE----VGNSKCTAILTVE 1192
I D DD +Y+C+ +G + CTA L VE
Sbjct: 527 ISDVCGDDDAKYTCKAVNSLGEATCTAELIVE 558
Score = 38.7 bits (86), Expect = 0.23
Identities = 20/68 (29%), Positives = 34/68 (50%), Gaps = 1/68 (1%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSV-IRIKELKRSHSSKYTIEASNTAGTS 1654
IEG P PEV+W K+ + + + I E + + I ++ +KYT +A N+ G +
Sbjct: 490 IEGYPDPEVVWSKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 549
Query: 1655 SVEVTLKV 1662
+ L V
Sbjct: 550 TCTAELIV 557
>AF200348-1|AAF06354.1| 1496|Homo sapiens melanoma-associated antigen
MG50 protein.
Length = 1496
Score = 86.6 bits (205), Expect = 9e-16
Identities = 95/391 (24%), Positives = 152/391 (38%), Gaps = 29/391 (7%)
Query: 825 PTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFD 884
P E N E P + Q+ V T+ R NP P I W RNN +S N
Sbjct: 255 PEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLL 314
Query: 885 GENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI----DVEKVTFVKHLQKSYET 940
+ L+I N E D G Y+C+A N AG+ VT+ + TFV Q + E
Sbjct: 315 DDG-TLMIQNT-QETDQGIYQCMAKNVAGEVK-TQEVTLRYFGSPARPTFVIQPQNT-EV 370
Query: 941 EEGKTVILECQ-TSH-TVSTKWYHNKKEISGMDHR-EIIQEGRXXXXXXXXXXXXDVGVI 997
G++V LEC T H W + +D R I G +
Sbjct: 371 LVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACS 430
Query: 998 KCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVV-WERDGEII 1056
D +T ++ + +P+F QD V E + E V+ W + G +
Sbjct: 431 ATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL 490
Query: 1057 KPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC----ILRDESCTAEVTV-VELPPEIIT 1111
+ ++ G +R I ++HD+G+Y C I+ + A +TV + P +
Sbjct: 491 SVDR-RHLVLSSGTLR---ISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 546
Query: 1112 RLQNQKVNKGNKATFEIELT-KGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDL 1170
+ V G + + + W KDG ++ S ++ +G L I D
Sbjct: 547 IPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG---FLTINDVGP 603
Query: 1171 DDAGEYSC----EVGNSKCTAILTVEEPSIN 1197
DAG Y C +G++ + +L+V P ++
Sbjct: 604 ADAGRYECVARNTIGSASVSMVLSVNVPDVS 634
Score = 86.2 bits (204), Expect = 1e-15
Identities = 94/417 (22%), Positives = 155/417 (37%), Gaps = 29/417 (6%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS 693
P + +P+ V G+ + CR P+P+I WL E+ + + + D
Sbjct: 263 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDD-----G 317
Query: 694 VLKITNVKKFQEGTYTVVAVNREGEASLP-IVLKIKTGEKEPPQVIEPLKSMIVRQGESV 752
L I N ++ +G Y +A N GE + L+ P VI+P + ++ GESV
Sbjct: 318 TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVL-VGESV 376
Query: 753 ILSAQVVGNPRPTITWCKNNK-PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSE 811
L G+P P I+W + ++ P+ P + + + I + D G Y A N+
Sbjct: 377 TLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ-GDSGEYACSATNNI 435
Query: 812 GIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNE 871
+A I V+ + P Q+ V E T+ NP P I W +
Sbjct: 436 DSVHATAFIIVQALPQFTVTP-------QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGS 488
Query: 872 IISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFV 931
+S G L I+ V D G Y+C A N G A +T+
Sbjct: 489 QLSVDRRHLVLSSG---TLRISGVALH-DQGQYECQAVNIIGSQKVVAHLTVQPRVTPVF 544
Query: 932 KHLQKSYETEEGKTVILEC--QTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXX 989
+ E G V L C Q + W + +++ I EG
Sbjct: 545 ASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG---FLTINDV 601
Query: 990 XXXDVGVIKCIVKDQ--ETSTMLVVKETIPEFIRKLQDFEVKE--KDVAILEVEINS 1042
D G +C+ ++ S +V+ +P+ R F + +A ++ INS
Sbjct: 602 GPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINS 658
Score = 72.9 bits (171), Expect = 1e-11
Identities = 91/386 (23%), Positives = 154/386 (39%), Gaps = 36/386 (9%)
Query: 733 EPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSI--- 789
E P++ + V G +V + + GNP+P I W +NN L K+D + +
Sbjct: 261 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNN---NELSMKTDSRLNLLDDG 317
Query: 790 -TILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKG 848
+++ + D+G+Y A+N G +T V T+ + P F+ + Q V
Sbjct: 318 TLMIQNTQETDQGIYQCMAKNVAGEVKTQEV-TLR--YFGSPARPTFVIQPQNTEVLVGE 374
Query: 849 TIKLVARVTRNPVPSITWYRNNEI---ISPSETITQNFDGENIELVITNVDSEIDSGDYK 905
++ L T +P P I+W R + + P IT + G I+ V+ DSG+Y
Sbjct: 375 SVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPS-GGLYIQNVVQG-----DSGEYA 428
Query: 906 CVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVS--TKWYHN 963
C A+N+ S H A I V+ + + EG+TV +C+ W
Sbjct: 429 CSATNNI-DSVH-ATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG 486
Query: 964 KKEISGMDHREIIQEGRXXXXXXXXXXXXDVGVIKC----IVKDQETSTMLVVKETI-PE 1018
++S +D R ++ D G +C I+ Q+ L V+ + P
Sbjct: 487 GSQLS-VDRRHLVLS--SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV 543
Query: 1019 FIRKLQDFEVKEKDVAILEVEINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIR 1077
F D V+ L E + W +DG + + K+ G L I
Sbjct: 544 FASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG-VQVTESGKFHISPEGF---LTIN 599
Query: 1078 NTSVHDEGEYSCILRDESCTAEVTVV 1103
+ D G Y C+ R+ +A V++V
Sbjct: 600 DVGPADAGRYECVARNTIGSASVSMV 625
Score = 62.9 bits (146), Expect = 1e-08
Identities = 77/320 (24%), Positives = 129/320 (40%), Gaps = 26/320 (8%)
Query: 1074 LYIRNTSVHDEGEYSCILRD---ESCTAEVTV----VELPPEIITRLQNQKVNKGNKATF 1126
L I+NT D+G Y C+ ++ E T EVT+ P + + QN +V G T
Sbjct: 319 LMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTL 378
Query: 1127 EIELT-KGDALVRWFK-DGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNS- 1183
E T + W + D + + + +T G L I + D+GEY+C N+
Sbjct: 379 ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG---LYIQNVVQGDSGEYACSATNNI 435
Query: 1184 ---KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTE 1240
TA + V+ FT+ + +++ T + + + W K S +
Sbjct: 436 DSVHATAFIIVQALP-QFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR 494
Query: 1241 KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVVEFP---PKIVDYEREY 1297
+ ++S TL I DQ +Y C ++ + K+ + P P +
Sbjct: 495 RHLVLSS---GTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 551
Query: 1298 RIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGI 1357
++ G++V L Q P+P W N ++ + K I S LTI V DAG
Sbjct: 552 TVEVGANVQLPCSSQGEPEPAITW--NKDGVQVTESGKFHI-SPEGFLTINDVGPADAGR 608
Query: 1358 YKLRLENNCGHADVEMNVTI 1377
Y+ N G A V M +++
Sbjct: 609 YECVARNTIGSASVSMVLSV 628
Score = 58.0 bits (134), Expect = 3e-07
Identities = 77/428 (17%), Positives = 159/428 (37%), Gaps = 18/428 (4%)
Query: 1264 CEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV 1323
CEY + T E+ P+I ++ + G+ V + P+P W+
Sbjct: 239 CEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR 298
Query: 1324 NSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSP 1383
N+ + ++ ++ +L I+ + TD GIY+ +N G + VT+ SP
Sbjct: 299 NNNELSMKTDSRLNL-LDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQ-EVTLRYFGSP 356
Query: 1384 PGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTS---I 1440
+++ ++ + + + + + D T + T + I
Sbjct: 357 ARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYI 416
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE 1500
QN+ S + A N +D A+ +I + Q P + E + ++
Sbjct: 417 QNVVQGDSGEYACSATNNIDSVHATAF-----IIVQALPQFTVT--PQDRVVIE-GQTVD 468
Query: 1501 LTCIFGGVPQPKVTWYRDGKKLKTAKATYE-NRXXXXXXXXXXXXXXXYKCIAFNDHGEV 1559
C G P P + W + G +L + + Y+C A N G
Sbjct: 469 FQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQ 528
Query: 1560 ETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEY 1619
+ + +Q + ++ +VG + +G P P + W K+G ++ ++
Sbjct: 529 KVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKF 588
Query: 1620 NITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV-YDKPSKPEGPVIMREI 1678
+I+ + + I ++ + + +Y A NT G++SV + L V S+ P + I
Sbjct: 589 HISPE---GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSI 645
Query: 1679 SRESVTIE 1686
T++
Sbjct: 646 VEAIATVD 653
Score = 54.8 bits (126), Expect = 3e-06
Identities = 26/67 (38%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G+TV F C+ EG P+P+I W R + D ++ DD TL+I+ D G + C
Sbjct: 277 GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDD--GTLMIQNTQETDQGIYQC 334
Query: 584 VAKNAAG 590
+AKN AG
Sbjct: 335 MAKNVAG 341
Score = 53.6 bits (123), Expect = 7e-06
Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 508 MAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVAT 567
+ P+F G+ VQ C +G P P ITW + + S F + +
Sbjct: 540 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPE----GF 595
Query: 568 LVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAP 603
L I +V P DAG + CVA+N G AS + L V P
Sbjct: 596 LTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 631
Score = 41.5 bits (93), Expect = 0.032
Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 632 IPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
+ P F+ P V+ G+++ L C PEP I W G ++ ++ E
Sbjct: 540 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPE------ 593
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L I +V G Y VA N G AS+ +VL +
Sbjct: 594 -GFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 628
Score = 38.3 bits (85), Expect = 0.30
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 3/93 (3%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLV 569
P FV + + G +V EC G+P P+I+W R P D ++ L
Sbjct: 359 PTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLP-VDPRVNITPS--GGLY 415
Query: 570 IREVFPEDAGTFTCVAKNAAGFASSTTELIVEA 602
I+ V D+G + C A N +T +IV+A
Sbjct: 416 IQNVVQGDSGEYACSATNNIDSVHATAFIIVQA 448
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/79 (27%), Positives = 34/79 (43%), Gaps = 4/79 (5%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G TV F+C+ +G P P I W + + + + + + TL I V D G +
Sbjct: 463 EGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVL----SSGTLRISGVALHDQGQYE 518
Query: 583 CVAKNAAGFASSTTELIVE 601
C A N G L V+
Sbjct: 519 CQAVNIIGSQKVVAHLTVQ 537
>Z29373-1|CAA82564.1| 1257|Homo sapiens neural cell adhesion molecule
L1 protein.
Length = 1257
Score = 85.8 bits (203), Expect = 2e-15
Identities = 126/577 (21%), Positives = 222/577 (38%), Gaps = 50/577 (8%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PP +++ P+ V DI L+C PE W G P E + V + H
Sbjct: 34 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93
Query: 692 CSVLKITN---VKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ N ++FQ G Y A N+ G A S I L + K P + ++P++ V
Sbjct: 94 SFTITGNNSNFAQRFQ-GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE---VE 149
Query: 748 QGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+GESV+L + P + N+K +K + G ++ + Y
Sbjct: 150 EGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209
Query: 806 KAE--NSEGIAETSAVITVEEPTEE--NAEPPLFI--NRFQEITVKEKGTIKLVARVTRN 859
A + I + + + T + +P L N + + + L
Sbjct: 210 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P+I W R + + P++ +T + N L + V E D G+Y+C+A NS G + H
Sbjct: 270 PTPTIKWLRPSGPM-PADRVT--YQNHNKTLQLLKVGEE-DDGEYRCLAENSLGSARHAY 325
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGM--DHREI 975
VT VE + H +S+ G+T L+CQ + W N + + D +
Sbjct: 326 YVT--VEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYR 383
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQE-----TSTMLVVKETIPEFIRKLQDFEVKE 1030
IQ G D V +C +++ + + VV+ Q + +
Sbjct: 384 IQRG---ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ 440
Query: 1031 KDVAILEVE-INSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
A L + + V W + DG + + + + L IR+ +D G Y
Sbjct: 441 GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYAN----GTLGIRDLQANDTGRYF 496
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ ++ + V+ +I ++ KG++ TF + + +L + W D
Sbjct: 497 CLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGD 556
Query: 1143 GSEIQ-FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC 1178
G ++Q + + I+ +L I+ D D G YSC
Sbjct: 557 GRDLQELGDSDKYFIE--DGRLVIHSLDYSDQGNYSC 591
Score = 76.2 bits (179), Expect = 1e-12
Identities = 114/488 (23%), Positives = 188/488 (38%), Gaps = 47/488 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWL-FKGEEIVPDENISVAIESD 687
EG P + K V+EG ++L C EP I W+ K I DE +++ +
Sbjct: 133 EGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGN 192
Query: 688 MHMYCSVLKITNVKKFQ-----EGTYTVVAVNREGEASLPIVLKIKTGEK---EPPQVIE 739
++ + +VL N + GT T++ +E PI L++K P+++
Sbjct: 193 LY-FANVLTSDNHSDYICHAHFPGTRTII--QKE-----PIDLRVKATNSMIDRKPRLLF 244
Query: 740 PLKS---MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKK 796
P S ++ QG+ ++L G P PTI W + + P+ A ++ +LK +
Sbjct: 245 PTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGE 304
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+D+G Y AENS G A + +TVE P ++++ Q T +L +V
Sbjct: 305 -EDDGEYRCLAENSLGSARHAYYVTVE-------AAPYWLHKPQSHLYGPGETARLDCQV 356
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P P +TW R N I Q + + L+++NV D+ +C A N G
Sbjct: 357 QGRPQPEVTW-RINGIPVEELAKDQKYRIQRGALILSNVQPS-DTMVTQCEARNRHGLLL 414
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHRE 974
A + + + ++Y +G T L C+ + S +W D R
Sbjct: 415 ANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 474
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCI-VKDQETSTM---LVVKETIPEFIRKLQDFEVKE 1030
D G C+ DQ T+ L VK+ E K
Sbjct: 475 FPYAN--GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKG 532
Query: 1031 KDVAI-LEVEIN-SETADVVWERDGEIIKP--KKNKYDFEKRGHIRKLYIRNTSVHDEGE 1086
V + + S + W DG ++ +KY E +L I + D+G
Sbjct: 533 SRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED----GRLVIHSLDYSDQGN 588
Query: 1087 YSCILRDE 1094
YSC+ E
Sbjct: 589 YSCVASTE 596
Score = 66.1 bits (154), Expect = 1e-09
Identities = 142/729 (19%), Positives = 274/729 (37%), Gaps = 51/729 (6%)
Query: 1068 RGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRLQNQKVNKGNKA 1124
+ H + L + D+GEY C+ + +A VE P + + Q+ G A
Sbjct: 291 QNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETA 350
Query: 1125 TFEIELT-KGDALVRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ ++ + V W +G + + + + I ++ L + + D CE N
Sbjct: 351 RLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI--QRGALILSNVQPSDTMVTQCEARN 408
Query: 1183 S-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK--KSV 1235
I V+ P+ T ++ V +T L V W + +V
Sbjct: 409 RHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV 468
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYE 1294
++D F + TL IR +D Y C+ + ++ + + V+ +I
Sbjct: 469 LQDERFFPYANG----TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 524
Query: 1295 REYRIKRGSDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
R K+GS VT P QP+ W + + +++ + + L I ++
Sbjct: 525 RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYF-IEDGRLVIHSLDY 583
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK---PNILEIDSSSINICWDEPENTGN 1409
+D G Y + + ++ P P + ++ + S + + W P N
Sbjct: 584 SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSW-SPAEDHN 642
Query: 1410 STIIYYVVEYQ--EIDTTEWISVKNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASE 1466
+ I Y +E++ E+ +W S+ + QTS L Y FR A+N+ + S
Sbjct: 643 APIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSP 702
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE-LTCIFGGVPQP--KVTWYRDGKKLK 1523
+E + ++P K N TT + L + PQ +V W G +
Sbjct: 703 VSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGP 762
Query: 1524 TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE-VETSCVVGIQ----QKPVITISNE 1578
+ + K A N G+ E +G + + +
Sbjct: 763 WQEQIVSD-PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 821
Query: 1579 DIKQKHKVGDEW--LVTAVIEG-IPPPEVIWYKNGNKLENDKEY----NITTKEKTSVIR 1631
+I V +W + A ++G + V +++ G++ ++ K + ++ T+ +
Sbjct: 822 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 881
Query: 1632 IKELKRSHSSKYTIEASNTAGTS-SVEVTLKVYD-KPSKPEGPVIMREISRESVTIEWKP 1689
+ L+ S ++A N G+ + E T + P PE + + S S+ + W+P
Sbjct: 882 LSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEA-LHLECQSNTSLLLRWQP 940
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE--TYCIQKLNENCEYMFRVIAQNPV 1747
PL G+ LT Y + H D +++ RD E T+ + L+ + Y F++ A
Sbjct: 941 PLSHNGV-LTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKE 999
Query: 1748 GFSEALESE 1756
G EA+ E
Sbjct: 1000 GPGEAIVRE 1008
Score = 49.6 bits (113), Expect = 1e-04
Identities = 39/176 (22%), Positives = 68/176 (38%), Gaps = 10/176 (5%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFND 1555
+ + L CI G P P + W R + + TY+N Y+C+A N
Sbjct: 258 QPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENS 317
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG---NK 1612
G + V ++ P ++ + G+ + ++G P PEV W NG +
Sbjct: 318 LGSARHAYYVTVEAAPYWL--HKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEE 375
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
L D++Y I + + + ++ S + EA N G + V P+K
Sbjct: 376 LAKDQKYRI----QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 427
Score = 46.8 bits (106), Expect = 9e-04
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC EG+P P I W R + P ++ Y + N TL + +V ED G + C
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSG---PMPADRVTYQNHN-KTLQLLKVGEEDDGEYRC 312
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N+ G A + VEA
Sbjct: 313 LAENSLGSARHAYYVTVEA 331
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++ K + G T + +CQV+G P+P++TW ++ Q Y L
Sbjct: 332 APYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GAL 389
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
++ V P D C A+N G + + +V+ P
Sbjct: 390 ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 425
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 35/79 (44%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYP--RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V F CQ P +P ITW ++ D Y+ +D LVI + D G +
Sbjct: 532 GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG--RLVIHSLDYSDQGNY 589
Query: 582 TCVAKNAAGFASSTTELIV 600
+CVA S +L+V
Sbjct: 590 SCVASTELDVVESRAQLLV 608
>M77640-1|AAC14352.1| 1257|Homo sapiens L1 cell adhesion molecule
protein.
Length = 1257
Score = 85.8 bits (203), Expect = 2e-15
Identities = 126/577 (21%), Positives = 222/577 (38%), Gaps = 50/577 (8%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PP +++ P+ V DI L+C PE W G P E + V + H
Sbjct: 34 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93
Query: 692 CSVLKITN---VKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ N ++FQ G Y A N+ G A S I L + K P + ++P++ V
Sbjct: 94 SFTITGNNSNFAQRFQ-GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE---VE 149
Query: 748 QGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+GESV+L + P + N+K +K + G ++ + Y
Sbjct: 150 EGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209
Query: 806 KAE--NSEGIAETSAVITVEEPTEE--NAEPPLFI--NRFQEITVKEKGTIKLVARVTRN 859
A + I + + + T + +P L N + + + L
Sbjct: 210 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P+I W R + + P++ +T + N L + V E D G+Y+C+A NS G + H
Sbjct: 270 PTPTIKWLRPSGPM-PADRVT--YQNHNKTLQLLKVGEE-DDGEYRCLAENSLGSARHAY 325
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGM--DHREI 975
VT VE + H +S+ G+T L+CQ + W N + + D +
Sbjct: 326 YVT--VEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYR 383
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQE-----TSTMLVVKETIPEFIRKLQDFEVKE 1030
IQ G D V +C +++ + + VV+ Q + +
Sbjct: 384 IQRG---ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ 440
Query: 1031 KDVAILEVE-INSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
A L + + V W + DG + + + + L IR+ +D G Y
Sbjct: 441 GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYAN----GTLGIRDLQANDTGRYF 496
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ ++ + V+ +I ++ KG++ TF + + +L + W D
Sbjct: 497 CLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGD 556
Query: 1143 GSEIQ-FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC 1178
G ++Q + + I+ +L I+ D D G YSC
Sbjct: 557 GRDLQELGDSDKYFIE--DGRLVIHSLDYSDQGNYSC 591
Score = 76.2 bits (179), Expect = 1e-12
Identities = 114/488 (23%), Positives = 188/488 (38%), Gaps = 47/488 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWL-FKGEEIVPDENISVAIESD 687
EG P + K V+EG ++L C EP I W+ K I DE +++ +
Sbjct: 133 EGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGN 192
Query: 688 MHMYCSVLKITNVKKFQ-----EGTYTVVAVNREGEASLPIVLKIKTGEK---EPPQVIE 739
++ + +VL N + GT T++ +E PI L++K P+++
Sbjct: 193 LY-FANVLTSDNHSDYICHAHFPGTRTII--QKE-----PIDLRVKATNSMIDRKPRLLF 244
Query: 740 PLKS---MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKK 796
P S ++ QG+ ++L G P PTI W + + P+ A ++ +LK +
Sbjct: 245 PTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGE 304
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+D+G Y AENS G A + +TVE P ++++ Q T +L +V
Sbjct: 305 -EDDGEYRCLAENSLGSARHAYYVTVE-------AAPYWLHKPQSHLYGPGETARLDCQV 356
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P P +TW R N I Q + + L+++NV D+ +C A N G
Sbjct: 357 QGRPQPEVTW-RINGIPVEELAKDQKYRIQRGALILSNVQPS-DTMVTQCEARNRHGLLL 414
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHRE 974
A + + + ++Y +G T L C+ + S +W D R
Sbjct: 415 ANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 474
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCI-VKDQETSTM---LVVKETIPEFIRKLQDFEVKE 1030
D G C+ DQ T+ L VK+ E K
Sbjct: 475 FPYAN--GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKG 532
Query: 1031 KDVAI-LEVEIN-SETADVVWERDGEIIKP--KKNKYDFEKRGHIRKLYIRNTSVHDEGE 1086
V + + S + W DG ++ +KY E +L I + D+G
Sbjct: 533 SRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED----GRLVIHSLDYSDQGN 588
Query: 1087 YSCILRDE 1094
YSC+ E
Sbjct: 589 YSCVASTE 596
Score = 66.1 bits (154), Expect = 1e-09
Identities = 142/729 (19%), Positives = 274/729 (37%), Gaps = 51/729 (6%)
Query: 1068 RGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRLQNQKVNKGNKA 1124
+ H + L + D+GEY C+ + +A VE P + + Q+ G A
Sbjct: 291 QNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETA 350
Query: 1125 TFEIELT-KGDALVRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ ++ + V W +G + + + + I ++ L + + D CE N
Sbjct: 351 RLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI--QRGALILSNVQPSDTMVTQCEARN 408
Query: 1183 S-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK--KSV 1235
I V+ P+ T ++ V +T L V W + +V
Sbjct: 409 RHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV 468
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYE 1294
++D F + TL IR +D Y C+ + ++ + + V+ +I
Sbjct: 469 LQDERFFPYANG----TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 524
Query: 1295 REYRIKRGSDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
R K+GS VT P QP+ W + + +++ + + L I ++
Sbjct: 525 RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYF-IEDGRLVIHSLDY 583
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK---PNILEIDSSSINICWDEPENTGN 1409
+D G Y + + ++ P P + ++ + S + + W P N
Sbjct: 584 SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSW-SPAEDHN 642
Query: 1410 STIIYYVVEYQ--EIDTTEWISVKNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASE 1466
+ I Y +E++ E+ +W S+ + QTS L Y FR A+N+ + S
Sbjct: 643 APIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSP 702
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE-LTCIFGGVPQP--KVTWYRDGKKLK 1523
+E + ++P K N TT + L + PQ +V W G +
Sbjct: 703 VSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGP 762
Query: 1524 TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE-VETSCVVGIQ----QKPVITISNE 1578
+ + K A N G+ E +G + + +
Sbjct: 763 WQEQIVSD-PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 821
Query: 1579 DIKQKHKVGDEW--LVTAVIEG-IPPPEVIWYKNGNKLENDKEY----NITTKEKTSVIR 1631
+I V +W + A ++G + V +++ G++ ++ K + ++ T+ +
Sbjct: 822 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 881
Query: 1632 IKELKRSHSSKYTIEASNTAGTS-SVEVTLKVYD-KPSKPEGPVIMREISRESVTIEWKP 1689
+ L+ S ++A N G+ + E T + P PE + + S S+ + W+P
Sbjct: 882 LSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEA-LHLECQSNTSLLLRWQP 940
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE--TYCIQKLNENCEYMFRVIAQNPV 1747
PL G+ LT Y + H D +++ RD E T+ + L+ + Y F++ A
Sbjct: 941 PLSHNGV-LTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKE 999
Query: 1748 GFSEALESE 1756
G EA+ E
Sbjct: 1000 GPGEAIVRE 1008
Score = 49.6 bits (113), Expect = 1e-04
Identities = 39/176 (22%), Positives = 68/176 (38%), Gaps = 10/176 (5%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFND 1555
+ + L CI G P P + W R + + TY+N Y+C+A N
Sbjct: 258 QPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENS 317
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG---NK 1612
G + V ++ P ++ + G+ + ++G P PEV W NG +
Sbjct: 318 LGSARHAYYVTVEAAPYWL--HKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEE 375
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
L D++Y I + + + ++ S + EA N G + V P+K
Sbjct: 376 LAKDQKYRI----QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 427
Score = 46.8 bits (106), Expect = 9e-04
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC EG+P P I W R + P ++ Y + N TL + +V ED G + C
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSG---PMPADRVTYQNHN-KTLQLLKVGEEDDGEYRC 312
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N+ G A + VEA
Sbjct: 313 LAENSLGSARHAYYVTVEA 331
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++ K + G T + +CQV+G P+P++TW ++ Q Y L
Sbjct: 332 APYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GAL 389
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
++ V P D C A+N G + + +V+ P
Sbjct: 390 ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 425
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 35/79 (44%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYP--RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V F CQ P +P ITW ++ D Y+ +D LVI + D G +
Sbjct: 532 GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG--RLVIHSLDYSDQGNY 589
Query: 582 TCVAKNAAGFASSTTELIV 600
+CVA S +L+V
Sbjct: 590 SCVASTELDVVESRAQLLV 608
>M74387-1|AAA59476.1| 1253|Homo sapiens cell adhesion molecule L1
protein.
Length = 1253
Score = 85.8 bits (203), Expect = 2e-15
Identities = 126/577 (21%), Positives = 222/577 (38%), Gaps = 50/577 (8%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PP +++ P+ V DI L+C PE W G P E + V + H
Sbjct: 34 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93
Query: 692 CSVLKITN---VKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ N ++FQ G Y A N+ G A S I L + K P + ++P++ V
Sbjct: 94 SFTITGNNSNFAQRFQ-GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE---VE 149
Query: 748 QGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+GESV+L + P + N+K +K + G ++ + Y
Sbjct: 150 EGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209
Query: 806 KAE--NSEGIAETSAVITVEEPTEE--NAEPPLFI--NRFQEITVKEKGTIKLVARVTRN 859
A + I + + + T + +P L N + + + L
Sbjct: 210 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P+I W R + + P++ +T + N L + V E D G+Y+C+A NS G + H
Sbjct: 270 PTPTIKWLRPSGPM-PADRVT--YQNHNKTLQLLKVGEE-DDGEYRCLAENSLGSARHAY 325
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGM--DHREI 975
VT VE + H +S+ G+T L+CQ + W N + + D +
Sbjct: 326 YVT--VEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYR 383
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQE-----TSTMLVVKETIPEFIRKLQDFEVKE 1030
IQ G D V +C +++ + + VV+ Q + +
Sbjct: 384 IQRG---ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ 440
Query: 1031 KDVAILEVE-INSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
A L + + V W + DG + + + + L IR+ +D G Y
Sbjct: 441 GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYAN----GTLGIRDLQANDTGRYF 496
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ ++ + V+ +I ++ KG++ TF + + +L + W D
Sbjct: 497 CLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGD 556
Query: 1143 GSEIQ-FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC 1178
G ++Q + + I+ +L I+ D D G YSC
Sbjct: 557 GRDLQELGDSDKYFIE--DGRLVIHSLDYSDQGNYSC 591
Score = 76.2 bits (179), Expect = 1e-12
Identities = 114/488 (23%), Positives = 188/488 (38%), Gaps = 47/488 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWL-FKGEEIVPDENISVAIESD 687
EG P + K V+EG ++L C EP I W+ K I DE +++ +
Sbjct: 133 EGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGN 192
Query: 688 MHMYCSVLKITNVKKFQ-----EGTYTVVAVNREGEASLPIVLKIKTGEK---EPPQVIE 739
++ + +VL N + GT T++ +E PI L++K P+++
Sbjct: 193 LY-FANVLTSDNHSDYICHAHFPGTRTII--QKE-----PIDLRVKATNSMIDRKPRLLF 244
Query: 740 PLKS---MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKK 796
P S ++ QG+ ++L G P PTI W + + P+ A ++ +LK +
Sbjct: 245 PTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGE 304
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+D+G Y AENS G A + +TVE P ++++ Q T +L +V
Sbjct: 305 -EDDGEYRCLAENSLGSARHAYYVTVE-------AAPYWLHKPQSHLYGPGETARLDCQV 356
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P P +TW R N I Q + + L+++NV D+ +C A N G
Sbjct: 357 QGRPQPEVTW-RINGIPVEELAKDQKYRIQRGALILSNVQPS-DTMVTQCEARNRHGLLL 414
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHRE 974
A + + + ++Y +G T L C+ + S +W D R
Sbjct: 415 ANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 474
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCI-VKDQETSTM---LVVKETIPEFIRKLQDFEVKE 1030
D G C+ DQ T+ L VK+ E K
Sbjct: 475 FPYAN--GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKG 532
Query: 1031 KDVAI-LEVEIN-SETADVVWERDGEIIKP--KKNKYDFEKRGHIRKLYIRNTSVHDEGE 1086
V + + S + W DG ++ +KY E +L I + D+G
Sbjct: 533 SRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED----GRLVIHSLDYSDQGN 588
Query: 1087 YSCILRDE 1094
YSC+ E
Sbjct: 589 YSCVASTE 596
Score = 66.1 bits (154), Expect = 1e-09
Identities = 142/729 (19%), Positives = 274/729 (37%), Gaps = 51/729 (6%)
Query: 1068 RGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRLQNQKVNKGNKA 1124
+ H + L + D+GEY C+ + +A VE P + + Q+ G A
Sbjct: 291 QNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETA 350
Query: 1125 TFEIELT-KGDALVRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ ++ + V W +G + + + + I ++ L + + D CE N
Sbjct: 351 RLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI--QRGALILSNVQPSDTMVTQCEARN 408
Query: 1183 S-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK--KSV 1235
I V+ P+ T ++ V +T L V W + +V
Sbjct: 409 RHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV 468
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYE 1294
++D F + TL IR +D Y C+ + ++ + + V+ +I
Sbjct: 469 LQDERFFPYANG----TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 524
Query: 1295 REYRIKRGSDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
R K+GS VT P QP+ W + + +++ + + L I ++
Sbjct: 525 RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYF-IEDGRLVIHSLDY 583
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK---PNILEIDSSSINICWDEPENTGN 1409
+D G Y + + ++ P P + ++ + S + + W P N
Sbjct: 584 SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSW-SPAEDHN 642
Query: 1410 STIIYYVVEYQ--EIDTTEWISVKNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASE 1466
+ I Y +E++ E+ +W S+ + QTS L Y FR A+N+ + S
Sbjct: 643 APIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSP 702
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE-LTCIFGGVPQP--KVTWYRDGKKLK 1523
+E + ++P K N TT + L + PQ +V W G +
Sbjct: 703 VSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGP 762
Query: 1524 TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE-VETSCVVGIQ----QKPVITISNE 1578
+ + K A N G+ E +G + + +
Sbjct: 763 WQEQIVSD-PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 821
Query: 1579 DIKQKHKVGDEW--LVTAVIEG-IPPPEVIWYKNGNKLENDKEY----NITTKEKTSVIR 1631
+I V +W + A ++G + V +++ G++ ++ K + ++ T+ +
Sbjct: 822 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 881
Query: 1632 IKELKRSHSSKYTIEASNTAGTS-SVEVTLKVYD-KPSKPEGPVIMREISRESVTIEWKP 1689
+ L+ S ++A N G+ + E T + P PE + + S S+ + W+P
Sbjct: 882 LSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEA-LHLECQSNTSLLLRWQP 940
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE--TYCIQKLNENCEYMFRVIAQNPV 1747
PL G+ LT Y + H D +++ RD E T+ + L+ + Y F++ A
Sbjct: 941 PLSHNGV-LTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKE 999
Query: 1748 GFSEALESE 1756
G EA+ E
Sbjct: 1000 GPGEAIVRE 1008
Score = 49.6 bits (113), Expect = 1e-04
Identities = 39/176 (22%), Positives = 68/176 (38%), Gaps = 10/176 (5%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFND 1555
+ + L CI G P P + W R + + TY+N Y+C+A N
Sbjct: 258 QPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENS 317
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG---NK 1612
G + V ++ P ++ + G+ + ++G P PEV W NG +
Sbjct: 318 LGSARHAYYVTVEAAPYWL--HKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEE 375
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
L D++Y I + + + ++ S + EA N G + V P+K
Sbjct: 376 LAKDQKYRI----QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 427
Score = 46.8 bits (106), Expect = 9e-04
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC EG+P P I W R + P ++ Y + N TL + +V ED G + C
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSG---PMPADRVTYQNHN-KTLQLLKVGEEDDGEYRC 312
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N+ G A + VEA
Sbjct: 313 LAENSLGSARHAYYVTVEA 331
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++ K + G T + +CQV+G P+P++TW ++ Q Y L
Sbjct: 332 APYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GAL 389
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
++ V P D C A+N G + + +V+ P
Sbjct: 390 ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 425
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 35/79 (44%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYP--RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V F CQ P +P ITW ++ D Y+ +D LVI + D G +
Sbjct: 532 GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG--RLVIHSLDYSDQGNY 589
Query: 582 TCVAKNAAGFASSTTELIV 600
+CVA S +L+V
Sbjct: 590 SCVASTELDVVESRAQLLV 608
>BC126229-1|AAI26230.1| 1257|Homo sapiens L1 cell adhesion molecule
protein.
Length = 1257
Score = 85.8 bits (203), Expect = 2e-15
Identities = 126/577 (21%), Positives = 222/577 (38%), Gaps = 50/577 (8%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PP +++ P+ V DI L+C PE W G P E + V + H
Sbjct: 34 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93
Query: 692 CSVLKITN---VKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ N ++FQ G Y A N+ G A S I L + K P + ++P++ V
Sbjct: 94 SFTITGNNSNFAQRFQ-GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE---VE 149
Query: 748 QGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+GESV+L + P + N+K +K + G ++ + Y
Sbjct: 150 EGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209
Query: 806 KAE--NSEGIAETSAVITVEEPTEE--NAEPPLFI--NRFQEITVKEKGTIKLVARVTRN 859
A + I + + + T + +P L N + + + L
Sbjct: 210 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P+I W R + + P++ +T + N L + V E D G+Y+C+A NS G + H
Sbjct: 270 PTPTIKWLRPSGPM-PADRVT--YQNHNKTLQLLKVGEE-DDGEYRCLAENSLGSARHAY 325
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGM--DHREI 975
VT VE + H +S+ G+T L+CQ + W N + + D +
Sbjct: 326 YVT--VEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYR 383
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQE-----TSTMLVVKETIPEFIRKLQDFEVKE 1030
IQ G D V +C +++ + + VV+ Q + +
Sbjct: 384 IQRG---ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ 440
Query: 1031 KDVAILEVE-INSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
A L + + V W + DG + + + + L IR+ +D G Y
Sbjct: 441 GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYAN----GTLGIRDLQANDTGRYF 496
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ ++ + V+ +I ++ KG++ TF + + +L + W D
Sbjct: 497 CLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGD 556
Query: 1143 GSEIQ-FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC 1178
G ++Q + + I+ +L I+ D D G YSC
Sbjct: 557 GRDLQELGDSDKYFIE--DGRLVIHSLDYSDQGNYSC 591
Score = 76.2 bits (179), Expect = 1e-12
Identities = 114/488 (23%), Positives = 188/488 (38%), Gaps = 47/488 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWL-FKGEEIVPDENISVAIESD 687
EG P + K V+EG ++L C EP I W+ K I DE +++ +
Sbjct: 133 EGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGN 192
Query: 688 MHMYCSVLKITNVKKFQ-----EGTYTVVAVNREGEASLPIVLKIKTGEK---EPPQVIE 739
++ + +VL N + GT T++ +E PI L++K P+++
Sbjct: 193 LY-FANVLTSDNHSDYICHAHFPGTRTII--QKE-----PIDLRVKATNSMIDRKPRLLF 244
Query: 740 PLKS---MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKK 796
P S ++ QG+ ++L G P PTI W + + P+ A ++ +LK +
Sbjct: 245 PTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGE 304
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+D+G Y AENS G A + +TVE P ++++ Q T +L +V
Sbjct: 305 -EDDGEYRCLAENSLGSARHAYYVTVE-------AAPYWLHKPQSHLYGPGETARLDCQV 356
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P P +TW R N I Q + + L+++NV D+ +C A N G
Sbjct: 357 QGRPQPEVTW-RINGIPVEELAKDQKYRIQRGALILSNVQPS-DTMVTQCEARNRHGLLL 414
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHRE 974
A + + + ++Y +G T L C+ + S +W D R
Sbjct: 415 ANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 474
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCI-VKDQETSTM---LVVKETIPEFIRKLQDFEVKE 1030
D G C+ DQ T+ L VK+ E K
Sbjct: 475 FPYAN--GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKG 532
Query: 1031 KDVAI-LEVEIN-SETADVVWERDGEIIKP--KKNKYDFEKRGHIRKLYIRNTSVHDEGE 1086
V + + S + W DG ++ +KY E +L I + D+G
Sbjct: 533 SRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED----GRLVIHSLDYSDQGN 588
Query: 1087 YSCILRDE 1094
YSC+ E
Sbjct: 589 YSCVASTE 596
Score = 66.1 bits (154), Expect = 1e-09
Identities = 142/729 (19%), Positives = 274/729 (37%), Gaps = 51/729 (6%)
Query: 1068 RGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRLQNQKVNKGNKA 1124
+ H + L + D+GEY C+ + +A VE P + + Q+ G A
Sbjct: 291 QNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETA 350
Query: 1125 TFEIELT-KGDALVRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ ++ + V W +G + + + + I ++ L + + D CE N
Sbjct: 351 RLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI--QRGALILSNVQPSDTMVTQCEARN 408
Query: 1183 S-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK--KSV 1235
I V+ P+ T ++ V +T L V W + +V
Sbjct: 409 RHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV 468
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYE 1294
++D F + TL IR +D Y C+ + ++ + + V+ +I
Sbjct: 469 LQDERFFPYANG----TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 524
Query: 1295 REYRIKRGSDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
R K+GS VT P QP+ W + + +++ + + L I ++
Sbjct: 525 RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYF-IEDGRLVIHSLDY 583
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK---PNILEIDSSSINICWDEPENTGN 1409
+D G Y + + ++ P P + ++ + S + + W P N
Sbjct: 584 SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSW-SPAEDHN 642
Query: 1410 STIIYYVVEYQ--EIDTTEWISVKNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASE 1466
+ I Y +E++ E+ +W S+ + QTS L Y FR A+N+ + S
Sbjct: 643 APIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSP 702
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE-LTCIFGGVPQP--KVTWYRDGKKLK 1523
+E + ++P K N TT + L + PQ +V W G +
Sbjct: 703 VSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGP 762
Query: 1524 TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE-VETSCVVGIQ----QKPVITISNE 1578
+ + K A N G+ E +G + + +
Sbjct: 763 WQEQIVSD-PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 821
Query: 1579 DIKQKHKVGDEW--LVTAVIEG-IPPPEVIWYKNGNKLENDKEY----NITTKEKTSVIR 1631
+I V +W + A ++G + V +++ G++ ++ K + ++ T+ +
Sbjct: 822 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 881
Query: 1632 IKELKRSHSSKYTIEASNTAGTS-SVEVTLKVYD-KPSKPEGPVIMREISRESVTIEWKP 1689
+ L+ S ++A N G+ + E T + P PE + + S S+ + W+P
Sbjct: 882 LSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEA-LHLECQSNTSLLLRWQP 940
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE--TYCIQKLNENCEYMFRVIAQNPV 1747
PL G+ LT Y + H D +++ RD E T+ + L+ + Y F++ A
Sbjct: 941 PLSHNGV-LTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKE 999
Query: 1748 GFSEALESE 1756
G EA+ E
Sbjct: 1000 GPGEAIVRE 1008
Score = 49.6 bits (113), Expect = 1e-04
Identities = 39/176 (22%), Positives = 68/176 (38%), Gaps = 10/176 (5%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFND 1555
+ + L CI G P P + W R + + TY+N Y+C+A N
Sbjct: 258 QPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENS 317
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG---NK 1612
G + V ++ P ++ + G+ + ++G P PEV W NG +
Sbjct: 318 LGSARHAYYVTVEAAPYWL--HKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEE 375
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
L D++Y I + + + ++ S + EA N G + V P+K
Sbjct: 376 LAKDQKYRI----QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 427
Score = 46.8 bits (106), Expect = 9e-04
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC EG+P P I W R + P ++ Y + N TL + +V ED G + C
Sbjct: 257 GQPLVLECIAEGFPTPTIKWLRPSG---PMPADRVTYQNHN-KTLQLLKVGEEDDGEYRC 312
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N+ G A + VEA
Sbjct: 313 LAENSLGSARHAYYVTVEA 331
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++ K + G T + +CQV+G P+P++TW ++ Q Y L
Sbjct: 332 APYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GAL 389
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
++ V P D C A+N G + + +V+ P
Sbjct: 390 ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 425
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 35/79 (44%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYP--RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V F CQ P +P ITW ++ D Y+ +D LVI + D G +
Sbjct: 532 GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG--RLVIHSLDYSDQGNY 589
Query: 582 TCVAKNAAGFASSTTELIV 600
+CVA S +L+V
Sbjct: 590 SCVASTELDVVESRAQLLV 608
>AL137357-1|CAB70709.1| 1185|Homo sapiens hypothetical protein
protein.
Length = 1185
Score = 85.8 bits (203), Expect = 2e-15
Identities = 98/425 (23%), Positives = 175/425 (41%), Gaps = 50/425 (11%)
Query: 1658 VTLKVYDKPSKPEGPVIMRE-ISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRW-IK 1715
VT + D+P P P++ +E + SV + W+P DG + Y I+ E + RW +
Sbjct: 361 VTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPG-SDGLSPVRYYTIQTRELPSGRWALH 419
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXX 1775
A V + ++ + +L Y FRV A N +G SE E E + T P
Sbjct: 420 SASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE-ESESLTTLQAAPDEAPTILS 478
Query: 1776 XXXIDNESVYITWF-PSEKNGGSPIIDYKVE----------------IKQEGKKW----- 1813
SV I W P+E ++ +++ I G W
Sbjct: 479 VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTS 538
Query: 1814 ----KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQP 1869
+ + L+ + Y+ R+ N +G P + ++ +G+ + P + P
Sbjct: 539 MYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSSPPQEVFVGEAV-PTAAP 596
Query: 1870 RNFVVSESTSRSVTLKWTEP--ESNGGSPITNYIIEF-KTVKGKSWTKIVTVGGSVHEHC 1926
RN VV +T+ + + W P +S G I Y I F + +G ++ T+ + +
Sbjct: 597 RNVVVHGATATQLDVTWEPPPLDSQNGD-IQGYKIYFWEAQRGNLTERVKTLFLAENSVK 655
Query: 1927 IENIKEKDEIIFRISAENTVG---VSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++N+ + ++A N G S PT+ Q+ PS P++ ++ + + V
Sbjct: 656 LKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQT-----QQAAPSAPSS-VKFSELTTTSV 709
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWM-EVGKVDV---NTLKFNIRDLSENHTYMI 2039
SW P++ G L GY + + + ++ VDV + L ++DL+E TY
Sbjct: 710 NVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRF 768
Query: 2040 RIYAR 2044
RI A+
Sbjct: 769 RIRAK 773
Score = 60.9 bits (141), Expect = 5e-08
Identities = 33/120 (27%), Positives = 65/120 (54%), Gaps = 6/120 (5%)
Query: 1379 DKPSPPGKPNILEID--SSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITK 1435
D+P PP +P + + D + S+ + W EP + G S + YY ++ +E+ + W + +++
Sbjct: 367 DRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSH 425
Query: 1436 TQTS--IQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITT 1493
+S + LK +SY+FR A N++ S+ SE +E ++ ++PT+ + TT
Sbjct: 426 NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTT 485
Score = 58.0 bits (134), Expect = 3e-07
Identities = 63/259 (24%), Positives = 105/259 (40%), Gaps = 13/259 (5%)
Query: 1804 VEIKQEGKKW----KXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITI 1859
V + EG++W + + L+ T Y FR+ N +GTS P KI
Sbjct: 1 VGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQT 60
Query: 1860 GKTLTPPSQPRNFVVSESTSRSVTLKW---TEPESNGGSPITNYIIEFKTVKGKSWTKIV 1916
+ P P N + ++ S+ L+W E E NG Y I++ G T
Sbjct: 61 LQA-PPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSH 119
Query: 1917 TVGGSV-HEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEI 1975
V V ++ IE+++E E ++ A N +G S P SQ+V +VPS +
Sbjct: 120 VVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPW-SQTVVGRTRESVPSSGPTNVSA 177
Query: 1976 RMVGSNIVMTSWG-TPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLK-FNIRDLSE 2033
S+ ++ W PE D +LGY + ++ V+ N+ + + L +
Sbjct: 178 LATTSSSMLGRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGK 237
Query: 2034 NHTYMIRIYARNEIGLSEP 2052
Y +++ A IG P
Sbjct: 238 YVLYEVQVLAFTRIGDGSP 256
Score = 56.8 bits (131), Expect = 8e-07
Identities = 88/397 (22%), Positives = 152/397 (38%), Gaps = 34/397 (8%)
Query: 1632 IKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPE-GPVIMREISRESVTI--EWK 1688
I++L+ + ++A N G+ T+ + S P GP + ++ S ++ W
Sbjct: 131 IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLGRWS 190
Query: 1689 --PPLDDGGLELTKYAIEKHEPDNNR---WIKVADVDRDVETYCIQKLNENCEYMFRVIA 1743
P D GL L + K + + + W+ + R + + L + Y +V+A
Sbjct: 191 EVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQ---LTGLGKYVLYEVQVLA 247
Query: 1744 QNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYK 1803
+G + S P +++ LD + SV + W P G I+ Y+
Sbjct: 248 FTRIG--DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQ 304
Query: 1804 VEIKQEGKKWKXXXXXXXXXARIQK----LSINTTYQFRIYARN-----EIGTSLPYTSD 1854
+ + + Q L + Y FRI A+ E +L T++
Sbjct: 305 ITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKVWGEAAEALVVTTE 364
Query: 1855 DKITIGKTLTPPSQPRNFVVSEST-SRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWT 1913
+ PPS+P V E +RSV L W EP S+G SP+ Y I+ + + W
Sbjct: 365 KR----DRPQPPSRP--MVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWA 417
Query: 1914 -KIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAP 1972
+V + ++ +K FR+ A N +G S +E A PT
Sbjct: 418 LHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI- 476
Query: 1973 LEIRMVGSNIVMTSWGTPEWDG-GAPLLGYNIAIRDV 2008
L + + V+ W P D LLG+ I R++
Sbjct: 477 LSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYREL 513
Score = 49.2 bits (112), Expect = 2e-04
Identities = 35/126 (27%), Positives = 55/126 (43%), Gaps = 9/126 (7%)
Query: 1630 IRIKELKRSHSSKYTIEASNTAGTSSVEVTLKV---YDKPSKPEGPVIMREISRESVTIE 1686
+++K+L + ++ I A +E + P P P+I+R S ++ I
Sbjct: 755 LKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSS--AIAIH 812
Query: 1687 WKPPLDDGGLELTKYAIEKHEPDNNRW-IKVADVDRDVETYCIQK--LNENCEYMFRVIA 1743
W D G +T+Y IE D W I + D+ ++V +Y L Y FRVIA
Sbjct: 813 WSSG-DPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 871
Query: 1744 QNPVGF 1749
N GF
Sbjct: 872 VNDYGF 877
Score = 48.8 bits (111), Expect = 2e-04
Identities = 44/144 (30%), Positives = 67/144 (46%), Gaps = 13/144 (9%)
Query: 1337 SIDSKSASLTIKKVENTDAGI---YKLRLENNCGHADVEMNVTI---LDKPSPPGKPNIL 1390
++D K S KV++ G+ +++R + ++E NVT P PPG P I+
Sbjct: 744 TVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIV 803
Query: 1391 EIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTS----IQNLKT 1445
SS+I I W + G I YV+E + D W I +K+I K +S + LK
Sbjct: 804 RY-SSAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKP 861
Query: 1446 NSSYRFRAYAVNEVDISDASETTE 1469
SY FR AVN+ S ++
Sbjct: 862 GVSYDFRVIAVNDYGFGTPSSPSQ 885
>AJ621424-1|CAF18565.1| 1685|Homo sapiens myomesin 1 protein.
Length = 1685
Score = 85.8 bits (203), Expect = 2e-15
Identities = 98/407 (24%), Positives = 160/407 (39%), Gaps = 31/407 (7%)
Query: 1669 PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVETYC 1727
P + + E +R V + WKPP G E Y +EK E W +V ++ +
Sbjct: 640 PPTDLSVTEATRSYVVLSWKPP-GQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFA 698
Query: 1728 IQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYI 1786
+ L E Y FRV N G E E +E V+ LD+P D SV +
Sbjct: 699 LFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDT-SVVV 757
Query: 1787 TWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXARI--QKLSINTTYQFRIYARN 1843
+W E ++ Y +E G KW+ +R L +Y FR+ A N
Sbjct: 758 SW--EESKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVN 815
Query: 1844 EIGTSLPYTSDD-----KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPIT 1898
G S Y+ D K IG ++P P +S+ + E++ +
Sbjct: 816 AAGLS-EYSQDSEAIEVKAAIGGGVSPDVCP---ALSDEPGGLTASRGRVHEASPPTFQK 871
Query: 1899 NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
+ ++ K K + +G + E ++E+ + +A S P + ++ R
Sbjct: 872 DALLGSKPNKPSLPSSSQNLGQTEVSKVSETVQEELTPPPQKAAPQGKSKSDPLKKKTDR 931
Query: 1959 LEKHATVPSPPTAPLEIRMVGS--NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM---W 2013
+PP+ P +I + S + ++ W P+ GGA + GY + R+V + W
Sbjct: 932 --------APPSPPCDITCLESFRDSMVLGWKQPDKTGGAEITGYYVNYREVIDGVPGKW 983
Query: 2014 MEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
E V+ + I +L EN Y ++ A N GL P E FK
Sbjct: 984 REANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFK 1030
Score = 71.7 bits (168), Expect = 3e-11
Identities = 53/209 (25%), Positives = 86/209 (41%), Gaps = 10/209 (4%)
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGK 1811
+S+P+ KT PS +S+ + W +K GG+ I Y V ++ +G
Sbjct: 921 KSDPLKKKTDRAPPSPPCDITCLESF-RDSMVLGWKQPDKTGGAEITGYYVNYREVIDGV 979
Query: 1812 --KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK-TLTPP 1866
KW+ +I L N YQF++ A N G P + + T+ P
Sbjct: 980 PGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAVP 1039
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK--SWTKIVTVGGSVHE 1924
P + SE S+ L+W P +G +P+T Y ++ K K K W +
Sbjct: 1040 GPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNVY 1099
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE 1953
+ +KE +FR+ A N GV P++
Sbjct: 1100 LKVRGLKEGVSYVFRVRAINQAGVGKPSD 1128
Score = 66.1 bits (154), Expect = 1e-09
Identities = 34/114 (29%), Positives = 56/114 (49%), Gaps = 3/114 (2%)
Query: 1963 ATVPSPPTAPLEIRMVGSN--IVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD 2020
A + P APL+++ + +N ++ SW P DGG+P+LGY I +V W +
Sbjct: 504 AEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTP 563
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVI-PGEGSHADEEP 2073
V +F + L E +Y+ R+ A N++G+ P EP + P E + P
Sbjct: 564 VKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRP 617
Score = 64.5 bits (150), Expect = 4e-09
Identities = 53/234 (22%), Positives = 92/234 (39%), Gaps = 9/234 (3%)
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+T V ++ E + + +A+ + S + K P P + E R+S+ +
Sbjct: 893 QTEVSKVSETVQEELTPPPQKAAPQGKSKSDPLKKKTDRAPPSPPCDITCLESFRDSMVL 952
Query: 1686 EWKPPLDDGGLELTKYAIEKHEPDN---NRWIKVADVDRDVETYCIQKLNENCEYMFRVI 1742
WK P GG E+T Y + E + +W + E Y I L EN Y F+V
Sbjct: 953 GWKQPDKTGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVA 1012
Query: 1743 AQNPVGF-SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIID 1801
A N G + + SE + + +S+ + W P +G +P+
Sbjct: 1013 AMNMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTG 1072
Query: 1802 YKVEIKQEGKK---WKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLP 1850
Y V++K+ K W+ +++ L +Y FR+ A N+ G P
Sbjct: 1073 YFVDLKEAKAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKP 1126
Score = 61.7 bits (143), Expect = 3e-08
Identities = 49/198 (24%), Positives = 79/198 (39%), Gaps = 6/198 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT-VGGSVHE 1924
P P + V+E+T V L W P G I Y +E ++W ++ T +
Sbjct: 638 PGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIM-YFVEKCEAGTENWQRVNTELPVKSPR 696
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTESQSVR-LEKHATVPSPPTAPLEIRMVGSNIV 1983
+ ++ E FR+ N+ GV P+E+ V + +P P + R +++V
Sbjct: 697 FALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVV 756
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
+ SW E L+GY I W V +F L +Y+ R+ A
Sbjct: 757 V-SW--EESKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRA 813
Query: 2044 RNEIGLSEPLESDEPFKV 2061
N GLSE + E +V
Sbjct: 814 VNAAGLSEYSQDSEAIEV 831
Score = 61.3 bits (142), Expect = 4e-08
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 7/164 (4%)
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
PE+ WY+NG L K + + + L + YTI +
Sbjct: 439 PEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVF 498
Query: 1662 VYDKPSKPEG----PVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
V D ++ EG P+ ++ E +++ + I WK P DGG + Y I+K E + W +
Sbjct: 499 VRDADAEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQ 558
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS-EALESEPI 1758
D + + L E Y+FRV A N +G + SEP+
Sbjct: 559 CNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPV 602
Score = 60.9 bits (141), Expect = 5e-08
Identities = 55/239 (23%), Positives = 96/239 (40%), Gaps = 33/239 (13%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P+ P + E+ + + W +P +GGSPI Y I+ V SW++
Sbjct: 510 PAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARF 569
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTE----------SQSVRLEKHAT----------- 1964
+ + E IFR+ A N +G+ P+ ++ RL+ +
Sbjct: 570 PVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTE 629
Query: 1965 -------VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
VP PPT L + + V+ SW P G ++ Y + + W V
Sbjct: 630 EEPSEGIVPGPPT-DLSVTEATRSYVVLSWKPPGQRGHEGIM-YFVEKCEAGTENWQRVN 687
Query: 2018 -KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
++ V + +F + DL+E +Y R+ N G+ EP E+ E + G+ + PG+
Sbjct: 688 TELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATE--VTVVGDKLDIPKAPGK 744
Score = 55.6 bits (128), Expect = 2e-06
Identities = 49/197 (24%), Positives = 81/197 (41%), Gaps = 12/197 (6%)
Query: 1284 VEFPPKI-VDYEREYR-IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
+ F K V + RE + G V + + + F QP +W N + K + +
Sbjct: 405 IHFDDKFDVSFGREGETMSLGCRVVITPEIKHF-QPEIQWYRNGVPLSPSKWVQTLWSGE 463
Query: 1342 SASLTIKKVENTDAGIYKLRL------ENNCGHADV-EMNVTILDKPSPPGKPNILEIDS 1394
A+LT + D G+Y +R+ E + V + + I P+ P LE +
Sbjct: 464 RATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVKCLEANK 523
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFR 1452
I I W +P G S I+ Y ++ E+ T W + + + + L SY FR
Sbjct: 524 DYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFR 583
Query: 1453 AYAVNEVDISDASETTE 1469
AVN++ I S +E
Sbjct: 584 VRAVNKMGIGFPSRVSE 600
Score = 54.0 bits (124), Expect = 6e-06
Identities = 38/114 (33%), Positives = 56/114 (49%), Gaps = 6/114 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTT--EW--ISVKNITK 1435
PSPP LE S+ + W +P+ TG + I Y V Y+E ID +W +VK +++
Sbjct: 934 PSPPCDITCLESFRDSMVLGWKQPDKTGGAEITGYYVNYREVIDGVPGKWREANVKAVSE 993
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
I NLK N Y+F+ A+N + S +E +K +E I P LK
Sbjct: 994 EAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFK-CEEWTIAVPGPPHSLK 1046
Score = 51.2 bits (117), Expect = 4e-05
Identities = 47/233 (20%), Positives = 86/233 (36%), Gaps = 14/233 (6%)
Query: 488 LNEKIDKLPVFEKPTSEEQSM-APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
L + +++ + +E+ + AP F+ K R + V+ C + G+P P++TW++
Sbjct: 254 LRKTLEETETYHAKLNEDHLLHAPEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKN 313
Query: 547 TAIIKPSQDFQMYYDDD--NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
I + Y + + TL I ED + A N G S+ ++V+
Sbjct: 314 QVPINVHANPGKYIIESRYGMHTLEINACDFEDTAQYRASAMNVKGELSAYASVVVKRYK 373
Query: 605 SDHGSEMTVXXXXXXXXXXXXA--DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ F K + EG + L CR+V PE
Sbjct: 374 GEFDETRFHAGASTMPLSFGVTPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPE 433
Query: 663 -----PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTV 710
P+I W G + P + + + + L +++ K EG YT+
Sbjct: 434 IKHFQPEIQWYRNGVPLSPSKWVQTLWSGER----ATLTFSHLNKEDEGLYTI 482
Score = 49.2 bits (112), Expect = 2e-04
Identities = 81/384 (21%), Positives = 150/384 (39%), Gaps = 30/384 (7%)
Query: 457 YVQKHLTEEKGWVPAQYLMD---ENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFV 513
+++K E++G Q L D N+ T L + +K+ K F++ + P FV
Sbjct: 1304 FMEKLQDEDEGTYTFQ-LQDGKATNHSTVVLVGDVFKKLQKEAEFQRQ-EWIRKQGPHFV 1361
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
E L + T + V +C+V + I W++ I + D + TL+I E
Sbjct: 1362 EYLSWEVTGE-CNVLLKCKVANIKKETHIVWYKDEREISVDEKHDF---KDGICTLLITE 1417
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEA---PLSDHGSEMTVXXXXXXXXXXXXADIL 629
+DAG + + K+ G S +L+ EA + + ++ + L
Sbjct: 1418 FSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELMMEVCKKIALSATDLKIQSTAEGIQL 1477
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+ + K + GS I R+ + WL E P N D
Sbjct: 1478 YSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGEQIWLQINE---PTPN-------DKG 1527
Query: 690 MYCSVLKITNVKKFQEGTYTVVA-VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VR 747
Y V+++ + K + T + E A + + EK +V+ L ++ ++
Sbjct: 1528 KY--VMELFDGKTGHQKTVDLSGQAYDEAYAEFQRLKQAAIAEKNRARVLGGLPDVVTIQ 1585
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYT 804
+G+++ L+ V G+P P ++W KN K + + K + + + D G Y
Sbjct: 1586 EGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGKYG 1645
Query: 805 LKAENSEGIAETSAVITVEEPTEE 828
L +N G + ++V P EE
Sbjct: 1646 LVVKNKYGSETSDFTVSVFIPEEE 1669
Score = 44.8 bits (101), Expect = 0.003
Identities = 55/207 (26%), Positives = 85/207 (41%), Gaps = 39/207 (18%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTK----SDGDTH 787
P +I+P +S V + E+V L + G P P +TW KN P+ A P K S H
Sbjct: 277 PEFIIKP-RSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH 335
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-----------------PTEENA 830
++ I +D Y A N +G A + V+ P
Sbjct: 336 TLEI-NACDFEDTAQYRASAMNVKGELSAYASVVVKRYKGEFDETRFHAGASTMPLSFGV 394
Query: 831 EPPLFINRFQ-------EITVKEKG-TIKLVARVTRNPV-----PSITWYRNNEIISPSE 877
P + +RF+ +++ +G T+ L RV P P I WYRN +SPS+
Sbjct: 395 TPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPEIKHFQPEIQWYRNGVPLSPSK 454
Query: 878 TITQNFDGENIELVITNVDSEIDSGDY 904
+ + GE L ++++ E D G Y
Sbjct: 455 WVQTLWSGERATLTFSHLNKE-DEGLY 480
Score = 44.4 bits (100), Expect = 0.005
Identities = 32/142 (22%), Positives = 60/142 (42%), Gaps = 10/142 (7%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISVKN--ITKT 1436
P PP E+ S+ + W P ++G + + Y V+ +E E W + I
Sbjct: 1039 PGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNV 1098
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
++ LK SY FR A+N+ + S+ V+ ET+ P ++ + N+ +
Sbjct: 1099 YLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAG--PVVAETR---PGTKEVVVNVDDDGV 1153
Query: 1497 EDIELTCIFGGVPQPKVTWYRD 1518
+ C P+ + +W +D
Sbjct: 1154 ISLNFEC-DKMTPKSEFSWSKD 1174
Score = 44.0 bits (99), Expect = 0.006
Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 5/117 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP ++ E S + + W P G+ I+Y+ VE E T W V + +
Sbjct: 638 PGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYF-VEKCEAGTENWQRVNTELPVKSPR 696
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI-QSPTVEKPLKNITT 1493
++ +L SY FR N + + SE TE V + I ++P P +N T
Sbjct: 697 FALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDT 753
Score = 43.6 bits (98), Expect = 0.008
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNT 1650
+T + G PPPEV W KN L +D N+ + +T+ I + + S KY + N
Sbjct: 1592 LTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGKYGLVVKNK 1651
Query: 1651 AGTSSVEVTLKVY 1663
G+ + + T+ V+
Sbjct: 1652 YGSETSDFTVSVF 1664
Score = 43.2 bits (97), Expect = 0.010
Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 20/213 (9%)
Query: 996 VIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS--ETADVVWERDG 1053
V K + K+ E +++ P F+ L +EV + +L+ ++ + + +VW +D
Sbjct: 1337 VFKKLQKEAEFQRQEWIRKQGPHFVEYLS-WEVTGECNVLLKCKVANIKKETHIVWYKDE 1395
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE--SCTAEVTVV-----ELP 1106
I + K+DF K G I L I S D G Y IL+D+ + + +V EL
Sbjct: 1396 REISVDE-KHDF-KDG-ICTLLITEFSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELM 1452
Query: 1107 PEII-------TRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGK 1159
E+ T L+ Q +G + + D V W +GS I++S+ ++ + G+
Sbjct: 1453 MEVCKKIALSATDLKIQSTAEGIQLYSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGE 1512
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
+ L+I + +D G+Y E+ + K TV+
Sbjct: 1513 QIWLQINEPTPNDKGKYVMELFDGKTGHQKTVD 1545
Score = 41.5 bits (93), Expect = 0.032
Identities = 31/124 (25%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 1358 YKLRLENNCGHADVE--MNVTI----LDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+++R N+ G + VT+ LD P PGK +S+ + W+E ++
Sbjct: 710 FRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDA--KE 767
Query: 1412 IIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
++ Y +E + +W N + ++ + L T SY FR AVN +S+ S+ +E
Sbjct: 768 LVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSE 827
Query: 1470 YYKV 1473
+V
Sbjct: 828 AIEV 831
Score = 41.1 bits (92), Expect = 0.042
Identities = 19/82 (23%), Positives = 35/82 (42%)
Query: 842 ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDS 901
+T++E + L V +P P ++W +N + ++ + F+ N S DS
Sbjct: 1582 VTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADS 1641
Query: 902 GDYKCVASNSAGKSSHGARVTI 923
G Y V N G + V++
Sbjct: 1642 GKYGLVVKNKYGSETSDFTVSV 1663
Score = 40.3 bits (90), Expect = 0.074
Identities = 33/102 (32%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN----NEIISPSETITQNFDGENI 888
P FI + + TV EK +KL + P P +TWY+N N +P + I ++ G +
Sbjct: 277 PEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH- 335
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
L I D E D+ Y+ A N G+ S A V + K F
Sbjct: 336 TLEINACDFE-DTAQYRASAMNVKGELSAYASVVVKRYKGEF 376
Score = 39.5 bits (88), Expect = 0.13
Identities = 24/104 (23%), Positives = 44/104 (42%), Gaps = 4/104 (3%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P + EG + L C + P P+++WL + + D++ ++ E+ Y I
Sbjct: 1579 PDVVTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAY---FTING 1635
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ-VIEPLK 742
V G Y +V N+ G + + + E+E +E LK
Sbjct: 1636 VSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEEARMAALESLK 1679
Score = 39.1 bits (87), Expect = 0.17
Identities = 64/280 (22%), Positives = 115/280 (41%), Gaps = 40/280 (14%)
Query: 1126 FEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSK- 1184
FE + + W KD + S +++ G K K+ D +DD G YSC+V ++
Sbjct: 1158 FECDKMTPKSEFSWSKDYVSTEDSPRLEVESKGNKTKMTFKDLGMDDLGIYSCDVTDTDG 1217
Query: 1185 CTAILTVEEPSINFTLRLP---EFILVPANTDAYLTVEIPDETLDVTW------------ 1229
+ ++E + L L +F VP ++ L VEI ++ W
Sbjct: 1218 IASSYLIDEEELKRLLALSHEHKFPTVPVKSE--LAVEILEKGQVRFWMQAEKLSGNAKV 1275
Query: 1230 ---YKKKSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK----STTKLKV 1281
+ +K + E + K + + + + K ++D+ YT L D K ST L
Sbjct: 1276 NYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQLQDGKATNHSTVVLVG 1335
Query: 1282 EVVEFPPKIVDYER-EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH------- 1333
+V + K +++R E+ K+G + ++ + N IKK H
Sbjct: 1336 DVFKKLQKEAEFQRQEWIRKQGPHFVEYLSWEVTGECNVLLKCKVANIKKETHIVWYKDE 1395
Query: 1334 TKPSIDSKS------ASLTIKKVENTDAGIYKLRLENNCG 1367
+ S+D K +L I + DAGIY++ L+++ G
Sbjct: 1396 REISVDEKHDFKDGICTLLITEFSKKDAGIYEVILKDDRG 1435
Score = 39.1 bits (87), Expect = 0.17
Identities = 20/89 (22%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G + C V G P P+++W + + + ++ A I V D+G +
Sbjct: 1586 EGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGKYG 1645
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEM 611
V KN G S T++ V + + + M
Sbjct: 1646 LVVKNKYG--SETSDFTVSVFIPEEEARM 1672
Score = 38.3 bits (85), Expect = 0.30
Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 9/90 (10%)
Query: 747 RQGESVILSAQVVGNP-----RPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVK 798
R+GE++ L +VV P +P I W +N P+ K + T G+ ++T K +
Sbjct: 417 REGETMSLGCRVVITPEIKHFQPEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNK-E 475
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEE 828
DEG+YT++ E + SA + V + E
Sbjct: 476 DEGLYTIRVRMGEYYEQYSAYVFVRDADAE 505
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/93 (26%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 1433 ITKTQTSIQNLKTNSSYRFRAYAVNE----VDISDASETTEYY--KVIKETKIQSPT-VE 1485
++K TS + S + R + E + + E TE Y K+ ++ + +P +
Sbjct: 222 VSKQATSALQQEETSEKKSRKVVIREKAERLSLRKTLEETETYHAKLNEDHLLHAPEFII 281
Query: 1486 KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
KP + E E+++L C G P+P+VTWY++
Sbjct: 282 KPRSHTVWE-KENVKLHCSIAGWPEPRVTWYKN 313
Score = 36.3 bits (80), Expect = 1.2
Identities = 20/80 (25%), Positives = 35/80 (43%), Gaps = 1/80 (1%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS-KSASLTIKKVENTDAGI 1357
I+ G + L + P P W+ N K + H ++ ++A TI V D+G
Sbjct: 1584 IQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADSGK 1643
Query: 1358 YKLRLENNCGHADVEMNVTI 1377
Y L ++N G + V++
Sbjct: 1644 YGLVVKNKYGSETSDFTVSV 1663
Score = 34.3 bits (75), Expect = 4.9
Identities = 32/102 (31%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI-SVAIESDMHMYC 692
P F KP++ V E ++ L C + PEP + W I N IES M+
Sbjct: 277 PEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH- 335
Query: 693 SVLKITNVKKFQE-GTYTVVAVNREGEAS--LPIVLKIKTGE 731
L+I N F++ Y A+N +GE S +V+K GE
Sbjct: 336 -TLEI-NACDFEDTAQYRASAMNVKGELSAYASVVVKRYKGE 375
>AB102653-1|BAC81122.1| 1255|Homo sapiens L1 cell adhesion molecule
protein.
Length = 1255
Score = 85.8 bits (203), Expect = 2e-15
Identities = 126/577 (21%), Positives = 222/577 (38%), Gaps = 50/577 (8%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PP +++ P+ V DI L+C PE W G P E + V + H
Sbjct: 32 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 91
Query: 692 CSVLKITN---VKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ N ++FQ G Y A N+ G A S I L + K P + ++P++ V
Sbjct: 92 SFTITGNNSNFAQRFQ-GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE---VE 147
Query: 748 QGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+GESV+L + P + N+K +K + G ++ + Y
Sbjct: 148 EGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 207
Query: 806 KAE--NSEGIAETSAVITVEEPTEE--NAEPPLFI--NRFQEITVKEKGTIKLVARVTRN 859
A + I + + + T + +P L N + + + L
Sbjct: 208 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 267
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P+I W R + + P++ +T + N L + V E D G+Y+C+A NS G + H
Sbjct: 268 PTPTIKWLRPSGPM-PADRVT--YQNHNKTLQLLKVGEE-DDGEYRCLAENSLGSARHAY 323
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGM--DHREI 975
VT VE + H +S+ G+T L+CQ + W N + + D +
Sbjct: 324 YVT--VEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYR 381
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQE-----TSTMLVVKETIPEFIRKLQDFEVKE 1030
IQ G D V +C +++ + + VV+ Q + +
Sbjct: 382 IQRG---ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ 438
Query: 1031 KDVAILEVE-INSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
A L + + V W + DG + + + + L IR+ +D G Y
Sbjct: 439 GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYAN----GTLGIRDLQANDTGRYF 494
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ ++ + V+ +I ++ KG++ TF + + +L + W D
Sbjct: 495 CLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGD 554
Query: 1143 GSEIQ-FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC 1178
G ++Q + + I+ +L I+ D D G YSC
Sbjct: 555 GRDLQELGDSDKYFIE--DGRLVIHSLDYSDQGNYSC 589
Score = 76.2 bits (179), Expect = 1e-12
Identities = 114/488 (23%), Positives = 188/488 (38%), Gaps = 47/488 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWL-FKGEEIVPDENISVAIESD 687
EG P + K V+EG ++L C EP I W+ K I DE +++ +
Sbjct: 131 EGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGN 190
Query: 688 MHMYCSVLKITNVKKFQ-----EGTYTVVAVNREGEASLPIVLKIKTGEK---EPPQVIE 739
++ + +VL N + GT T++ +E PI L++K P+++
Sbjct: 191 LY-FANVLTSDNHSDYICHAHFPGTRTII--QKE-----PIDLRVKATNSMIDRKPRLLF 242
Query: 740 PLKS---MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKK 796
P S ++ QG+ ++L G P PTI W + + P+ A ++ +LK +
Sbjct: 243 PTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGE 302
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+D+G Y AENS G A + +TVE P ++++ Q T +L +V
Sbjct: 303 -EDDGEYRCLAENSLGSARHAYYVTVE-------AAPYWLHKPQSHLYGPGETARLDCQV 354
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P P +TW R N I Q + + L+++NV D+ +C A N G
Sbjct: 355 QGRPQPEVTW-RINGIPVEELAKDQKYRIQRGALILSNVQPS-DTMVTQCEARNRHGLLL 412
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHRE 974
A + + + ++Y +G T L C+ + S +W D R
Sbjct: 413 ANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 472
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCI-VKDQETSTM---LVVKETIPEFIRKLQDFEVKE 1030
D G C+ DQ T+ L VK+ E K
Sbjct: 473 FPYAN--GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKG 530
Query: 1031 KDVAI-LEVEIN-SETADVVWERDGEIIKP--KKNKYDFEKRGHIRKLYIRNTSVHDEGE 1086
V + + S + W DG ++ +KY E +L I + D+G
Sbjct: 531 SRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED----GRLVIHSLDYSDQGN 586
Query: 1087 YSCILRDE 1094
YSC+ E
Sbjct: 587 YSCVASTE 594
Score = 66.1 bits (154), Expect = 1e-09
Identities = 142/729 (19%), Positives = 274/729 (37%), Gaps = 51/729 (6%)
Query: 1068 RGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRLQNQKVNKGNKA 1124
+ H + L + D+GEY C+ + +A VE P + + Q+ G A
Sbjct: 289 QNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETA 348
Query: 1125 TFEIELT-KGDALVRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ ++ + V W +G + + + + I ++ L + + D CE N
Sbjct: 349 RLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI--QRGALILSNVQPSDTMVTQCEARN 406
Query: 1183 S-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK--KSV 1235
I V+ P+ T ++ V +T L V W + +V
Sbjct: 407 RHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV 466
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYE 1294
++D F + TL IR +D Y C+ + ++ + + V+ +I
Sbjct: 467 LQDERFFPYANG----TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP 522
Query: 1295 REYRIKRGSDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
R K+GS VT P QP+ W + + +++ + + L I ++
Sbjct: 523 RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYF-IEDGRLVIHSLDY 581
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK---PNILEIDSSSINICWDEPENTGN 1409
+D G Y + + ++ P P + ++ + S + + W P N
Sbjct: 582 SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSW-SPAEDHN 640
Query: 1410 STIIYYVVEYQ--EIDTTEWISVKNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASE 1466
+ I Y +E++ E+ +W S+ + QTS L Y FR A+N+ + S
Sbjct: 641 APIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSP 700
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE-LTCIFGGVPQP--KVTWYRDGKKLK 1523
+E + ++P K N TT + L + PQ +V W G +
Sbjct: 701 VSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGP 760
Query: 1524 TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE-VETSCVVGIQ----QKPVITISNE 1578
+ + K A N G+ E +G + + +
Sbjct: 761 WQEQIVSD-PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 819
Query: 1579 DIKQKHKVGDEW--LVTAVIEG-IPPPEVIWYKNGNKLENDKEY----NITTKEKTSVIR 1631
+I V +W + A ++G + V +++ G++ ++ K + ++ T+ +
Sbjct: 820 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 879
Query: 1632 IKELKRSHSSKYTIEASNTAGTS-SVEVTLKVYD-KPSKPEGPVIMREISRESVTIEWKP 1689
+ L+ S ++A N G+ + E T + P PE + + S S+ + W+P
Sbjct: 880 LSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEA-LHLECQSNTSLLLRWQP 938
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE--TYCIQKLNENCEYMFRVIAQNPV 1747
PL G+ LT Y + H D +++ RD E T+ + L+ + Y F++ A
Sbjct: 939 PLSHNGV-LTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKE 997
Query: 1748 GFSEALESE 1756
G EA+ E
Sbjct: 998 GPGEAIVRE 1006
Score = 49.6 bits (113), Expect = 1e-04
Identities = 39/176 (22%), Positives = 68/176 (38%), Gaps = 10/176 (5%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFND 1555
+ + L CI G P P + W R + + TY+N Y+C+A N
Sbjct: 256 QPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENS 315
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG---NK 1612
G + V ++ P ++ + G+ + ++G P PEV W NG +
Sbjct: 316 LGSARHAYYVTVEAAPYWL--HKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEE 373
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
L D++Y I + + + ++ S + EA N G + V P+K
Sbjct: 374 LAKDQKYRI----QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 425
Score = 46.8 bits (106), Expect = 9e-04
Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC EG+P P I W R + P ++ Y + N TL + +V ED G + C
Sbjct: 255 GQPLVLECIAEGFPTPTIKWLRPSG---PMPADRVTYQNHN-KTLQLLKVGEEDDGEYRC 310
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N+ G A + VEA
Sbjct: 311 LAENSLGSARHAYYVTVEA 329
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++ K + G T + +CQV+G P+P++TW ++ Q Y L
Sbjct: 330 APYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GAL 387
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
++ V P D C A+N G + + +V+ P
Sbjct: 388 ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 423
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 35/79 (44%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYP--RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V F CQ P +P ITW ++ D Y+ +D LVI + D G +
Sbjct: 530 GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG--RLVIHSLDYSDQGNY 587
Query: 582 TCVAKNAAGFASSTTELIV 600
+CVA S +L+V
Sbjct: 588 SCVASTELDVVESRAQLLV 606
>AK128020-1|BAC87234.1| 595|Homo sapiens ursor. protein.
Length = 595
Score = 85.4 bits (202), Expect = 2e-15
Identities = 94/415 (22%), Positives = 146/415 (35%), Gaps = 50/415 (12%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFR---QTAIIKPSQDFQMYYDDDNV 565
AP E R G + C+ G P P +TW R Q ++ +
Sbjct: 48 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 107
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIV--EAPLSDHGSEMTVXXXXXXXXXX 623
L V PED + C A+N G + LIV AP S TV
Sbjct: 108 GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVR--------- 158
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVA-IPEPDIAWLFKGEEIVPDENISV 682
+LEG P + L C ++A P P+ WL G + P S+
Sbjct: 159 ----VLEGQP-----------------VSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSI 197
Query: 683 AIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLK 742
+ +H + + G Y+ VA N G + L ++ PP++
Sbjct: 198 RADGSLH-------LDRALQEHAGRYSCVATNTAGSQHRDVELVVQV----PPRIHPTAT 246
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGV 802
I +G L G P PTITW K + + + ++ +D G
Sbjct: 247 HHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGA 306
Query: 803 YTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVP 862
Y A N+ G + ++V + + ++T K + L +P P
Sbjct: 307 YVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNADVPLQVTAKAGEEVTLDCEAKGSPPP 366
Query: 863 SITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSH 917
+TW +++ + P ++ L V DSG Y+C ASN AG +SH
Sbjct: 367 LVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVG---DSGHYECTASNPAGSASH 418
Score = 74.9 bits (176), Expect = 3e-12
Identities = 94/416 (22%), Positives = 151/416 (36%), Gaps = 42/416 (10%)
Query: 695 LKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVIL 754
L+I ++ GTYT AVN G+AS I L + PQ+ E + + V G S +L
Sbjct: 13 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG----HAPQLTELPRDVTVELGRSALL 68
Query: 755 SAQVVGNPRPTITWCK-NNKPV-----KALPTKSDGDTHSITILKPKKVKDEGVYTLKAE 808
+ + G P PT+TW + + +P+ ++S + + +D+ Y +A
Sbjct: 69 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEAR 128
Query: 809 NSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV-TRNPVPSITWY 867
N G + A + V PP + + V E + L V P+P W
Sbjct: 129 NVFGKVQAEARLIV-----TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWL 183
Query: 868 RNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEK 927
++ + P + DG L + E +G Y CVA+N+AG + + V
Sbjct: 184 KDGRPLPPGSRHSIRADG---SLHLDRALQE-HAGRYSCVATNTAGSQHRDVELVVQVP- 238
Query: 928 VTFVKHLQKSYETEEGKTVILECQTS--HTVSTKWYHNKKEISGM-DHREIIQEGRXXXX 984
+ + T EG L C S + W ++ H + +EG
Sbjct: 239 -PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---TL 294
Query: 985 XXXXXXXXDVGVIKCIV------KDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
D G C QE + K I + D ++ A EV
Sbjct: 295 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNADVPLQVTAKAGEEV 354
Query: 1039 EINSETAD-----VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSC 1089
++ E V W +D + P N+Y G +R + V D G Y C
Sbjct: 355 TLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLR---LAQVQVGDSGHYEC 407
Score = 65.3 bits (152), Expect = 2e-09
Identities = 81/339 (23%), Positives = 128/339 (37%), Gaps = 22/339 (6%)
Query: 593 SSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDIL 652
SS+ +L + A T + G P ++ P+ V+ G L
Sbjct: 8 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSAL 67
Query: 653 LECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCS-VLKITNVKKFQEGTYTVV 711
L CR P P + W +G+ + S S VL +V + Y
Sbjct: 68 LACRATGRPPPTVTWR-RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 126
Query: 712 AVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVV-GNPRPTITWCK 770
A N G+ L I TG PPQ+ ++ V +G+ V L V+ G P P W K
Sbjct: 127 ARNVFGKVQAEARL-IVTGH-APPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLK 184
Query: 771 NNKPV---KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTE 827
+ +P+ ++DG H L+ + G Y+ A N+ G + V+ P
Sbjct: 185 DGRPLPPGSRHSIRADGSLHLDRALQ----EHAGRYSCVATNTAGSQHRDVELVVQVP-- 238
Query: 828 ENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGEN 887
P + IT E L + P P+ITW + ++ S N E
Sbjct: 239 ----PRIHPTATHHIT-NEGVPASLPCVASGVPAPTITWTKETNALT-SRGPHYNVSKEG 292
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE 926
L+ S D+G Y C A+N+ G SS R++++ +
Sbjct: 293 TLLIAQ--PSAQDAGAYVCTATNTVGFSSQEMRLSVNTK 329
Score = 54.4 bits (125), Expect = 4e-06
Identities = 45/194 (23%), Positives = 73/194 (37%), Gaps = 11/194 (5%)
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATY--ENRXXXXXXX 1539
P + + T L C+ GVP P +TW ++ L + Y
Sbjct: 239 PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQ 298
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITIS---NEDI--KQKHKVGDEWLVTA 1594
Y C A N G + + KP I ++ N D+ + K G+E +
Sbjct: 299 PSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNADVPLQVTAKAGEEVTLDC 358
Query: 1595 VIEGIPPPEVIWYKNGNKLEN-DKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGT 1653
+G PPP V W K+ + Y + + +R+ +++ S Y ASN AG+
Sbjct: 359 EAKGSPPPLVTWTKDSRPVPPITNRYGLL---PSGSLRLAQVQVGDSGHYECTASNPAGS 415
Query: 1654 SSVEVTLKVYDKPS 1667
+S L V + S
Sbjct: 416 ASHRYVLGVQGRTS 429
Score = 50.8 bits (116), Expect = 5e-05
Identities = 51/216 (23%), Positives = 74/216 (34%), Gaps = 32/216 (14%)
Query: 521 TPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGT 580
T +G C G P P ITW ++T + +Y+ TL+I + +DAG
Sbjct: 250 TNEGVPASLPCVASGVPAPTITWTKETNALTSRGP---HYNVSKEGTLLIAQPSAQDAGA 306
Query: 581 FTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKP 640
+ C A N GF+S L V H AD+ P
Sbjct: 307 YVCTATNTVGFSSQEMRLSVNTKPRIH------------MNGSRNADV-----------P 343
Query: 641 KAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNV 700
G ++ L+C P P + W + P N + S L++ V
Sbjct: 344 LQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPS------GSLRLAQV 397
Query: 701 KKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ 736
+ G Y A N G AS VL ++ PQ
Sbjct: 398 QVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQ 433
Score = 46.8 bits (106), Expect = 9e-04
Identities = 48/196 (24%), Positives = 77/196 (39%), Gaps = 14/196 (7%)
Query: 1481 SPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR-DGKKL-------KTAKATYENR 1532
+P + + +++T E L C G P P VTW R DG+ L + +++ +
Sbjct: 48 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS 107
Query: 1533 XXXXXXXXXXXXXXXYKCIAFNDHGEV--ETSCVVGIQQKPVITISNEDIKQKHKVGDEW 1590
Y C A N G+V E +V P I S ++
Sbjct: 108 GVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS- 166
Query: 1591 LVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNT 1650
L V+ G P PE W K+G L ++I + + + H+ +Y+ A+NT
Sbjct: 167 LPCIVLAGRPLPERHWLKDGRPLPPGSRHSI---RADGSLHLDRALQEHAGRYSCVATNT 223
Query: 1651 AGTSSVEVTLKVYDKP 1666
AG+ +V L V P
Sbjct: 224 AGSQHRDVELVVQVPP 239
Score = 42.7 bits (96), Expect = 0.014
Identities = 69/329 (20%), Positives = 117/329 (35%), Gaps = 26/329 (7%)
Query: 1253 LIIRKCTEDDQCEYTCVLLDAKSTTKLKVEVV---EFPPKIVDYEREYRIKRGSDVTL-L 1308
L +DQ Y C + + + ++ PP+I R+ G V+L
Sbjct: 110 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPC 169
Query: 1309 VDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCG- 1367
+ P P W+ + + + ++ SI + SL + + AG Y N G
Sbjct: 170 IVLAGRPLPERHWLKDGRPLPP--GSRHSIRA-DGSLHLDRALQEHAGRYSCVATNTAGS 226
Query: 1368 -HADVEMNVTILDKPSPPGKPNILE--IDSSSINICWDEPENTGNSTIIYYVVEYQEIDT 1424
H DVE+ V + + P +I + +S + P T I + E +
Sbjct: 227 QHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPT-----ITWTKETNAL-- 279
Query: 1425 TEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQ---S 1481
T N++K T + + S+ AY + S V + +I S
Sbjct: 280 TSRGPHYNVSKEGTLL--IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGS 337
Query: 1482 PTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYE--NRXXXXXXX 1539
+ PL+ +T + E++ L C G P P VTW +D + + Y
Sbjct: 338 RNADVPLQ-VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQ 396
Query: 1540 XXXXXXXXYKCIAFNDHGEVETSCVVGIQ 1568
Y+C A N G V+G+Q
Sbjct: 397 VQVGDSGHYECTASNPAGSASHRYVLGVQ 425
Score = 39.1 bits (87), Expect = 0.17
Identities = 31/132 (23%), Positives = 52/132 (39%), Gaps = 5/132 (3%)
Query: 1252 TLIIRKCTEDDQCEYTCVLLDAKSTTKLKVE-VVEFPPKIVDYEREYRIKRGSDVTLLVD 1310
+L + + ++ Y+CV + + VE VV+ PP+I + G +L
Sbjct: 202 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCV 261
Query: 1311 YQAFPQPNDEWIVNSKIIKKCKHTKPSID-SKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
P P W + + P + SK +L I + DAG Y N G +
Sbjct: 262 ASGVPAPTITWTKETNALTS---RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS 318
Query: 1370 DVEMNVTILDKP 1381
EM +++ KP
Sbjct: 319 SQEMRLSVNTKP 330
>BC067107-1|AAH67107.1| 814|Homo sapiens putative neuronal cell
adhesion molecule protein.
Length = 814
Score = 84.6 bits (200), Expect = 3e-15
Identities = 79/330 (23%), Positives = 131/330 (39%), Gaps = 33/330 (10%)
Query: 605 SDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPD 664
SD G V A I F P+A +EG +C++ +P+P
Sbjct: 110 SDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL 169
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYC----SVLKITNVKKFQEGTYTVVAVN----RE 716
I W E V I++D Y VL+IT ++ G + VA N R
Sbjct: 170 ITW----------EKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Query: 717 GEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK-NNKPV 775
+ V +G + P ++ +++ + ++ +L GNPRP ++W + + +P+
Sbjct: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
Query: 776 KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAV--ITVEEPTEENAEPP 833
+ G + I+ V+ GVY A +A + V+ P E
Sbjct: 280 GVEGIQVLGTGN--LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAE------ 331
Query: 834 LFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVIT 893
F+ Q I+ T + P P +TW +N +++ P + N L I+
Sbjct: 332 -FVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHV--RLKNNNSTLTIS 388
Query: 894 NVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ E D Y+CVA NSAG S AR+T+
Sbjct: 389 GIGPE-DEAIYQCVAENSAGSSQASARLTV 417
Score = 73.3 bits (172), Expect = 9e-12
Identities = 77/303 (25%), Positives = 121/303 (39%), Gaps = 40/303 (13%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G +F+CQ+ G P+P ITW + I + Y L I + ED G F
Sbjct: 152 EGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE---RYTLLPKGVLQITGLRAEDGGIFH 208
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N A S HG+ +TV P P+
Sbjct: 209 CVASNIASIRIS------------HGARLTVSGSGSGAYK----------EPAILVGPEN 246
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKK 702
+ +LEC P P ++W + E I V + L I++V
Sbjct: 247 LTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQV-------LGTGNLIISDVTV 299
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNP 762
G Y V A NR G + + + + P + ++ +S+ G + + + Q G P
Sbjct: 300 QHSGVY-VCAANRPG-TRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEP 357
Query: 763 RPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
P +TW KN + P + K++ T +I+ + P +DE +Y AENS G ++ SA
Sbjct: 358 PPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGP---EDEAIYQCVAENSAGSSQASAR 414
Query: 820 ITV 822
+TV
Sbjct: 415 LTV 417
Score = 67.3 bits (157), Expect = 6e-10
Identities = 83/385 (21%), Positives = 140/385 (36%), Gaps = 15/385 (3%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F+ +P G I+L+CR+ P I W G E+ P+ S + + M
Sbjct: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVEL-PESTHSTLLANGSLMIRHFR 102
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
EG Y VA NR G L + K + ++ + +G
Sbjct: 103 LEPGGSPSDEGDYECVAQNRFG---LVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQ 159
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-A 814
Q+ G P+P ITW KN P+ + + + + +D G++ A N I
Sbjct: 160 CQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
A +TV + P + + +T+ T L T NP P ++W R +
Sbjct: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE-KVTFVKH 933
E I G L+I++V + SG Y C A+ + A+ + V+ FV+H
Sbjct: 280 GVEGIQVLGTG---NLIISDVTVQ-HSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQH 335
Query: 934 LQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXX 991
Q S G T + CQ W N + + H + +
Sbjct: 336 PQ-SISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRL--KNNNSTLTISGIGP 392
Query: 992 XDVGVIKCIVKDQETSTMLVVKETI 1016
D + +C+ ++ S+ + T+
Sbjct: 393 EDEAIYQCVAENSAGSSQASARLTV 417
Score = 65.7 bits (153), Expect = 2e-09
Identities = 67/297 (22%), Positives = 112/297 (37%), Gaps = 17/297 (5%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR-DGKKLKTAKATYENRXXXXXX 1538
+ P + +N+T ++ L C+ G P+P V+W R DG+ +
Sbjct: 236 KEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIIS 295
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV----GDEWLVTA 1594
Y C A V + Q + V+ E ++ + G + T
Sbjct: 296 DVTVQHSGVYVCAANRPGTRVRRTA----QGRLVVQAPAEFVQHPQSISRPAGTTAMFTC 351
Query: 1595 VIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+G PPP V W KNG L ++ K S + I + + Y A N+AG+S
Sbjct: 352 QAQGEPPPHVTWLKNGQVL--GPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSS 409
Query: 1655 SVEVTLKVYDKPSKPEGPVIMREISRES--VTIEWKPPLDDGGLELTKYAIEKHEPDNNR 1712
L V P P +R +S S V + W PL + E+ Y + + +
Sbjct: 410 QASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLAN-TKEIIGYVLHIRKAADPP 468
Query: 1713 WIKVAD-VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPS 1768
++ + V + + + L + Y F + A P G S A S P + T + P+
Sbjct: 469 ELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSA--SVPTLASTLGEAPA 523
Score = 63.3 bits (147), Expect = 9e-09
Identities = 45/192 (23%), Positives = 85/192 (44%), Gaps = 9/192 (4%)
Query: 1283 VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
VV+ P + V + + G+ Q P P+ W+ N +++ H + + + +
Sbjct: 325 VVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVR--LKNNN 382
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL---DKPSPPGKPNILEIDSSSINI 1399
++LTI + D IY+ EN+ G + +T+L P PP + + S+ + +
Sbjct: 383 STLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRV 442
Query: 1400 CWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKT--QTSIQNLKTNSSYRFRAYAV 1456
W EP II YV+ ++ D E + ++K+ Q + +L+ +++Y F A
Sbjct: 443 SWSEP-LANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAY 501
Query: 1457 NEVDISDASETT 1468
S AS T
Sbjct: 502 TPRGASSASVPT 513
Score = 62.1 bits (144), Expect = 2e-08
Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 3/89 (3%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
FV+ + P G+T F CQ +G P P +TW + ++ P ++ +N +TL I
Sbjct: 332 FVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRL---KNNNSTLTIS 388
Query: 572 EVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ PED + CVA+N+AG + ++ L V
Sbjct: 389 GIGPEDEAIYQCVAENSAGSSQASARLTV 417
Score = 48.8 bits (111), Expect = 2e-04
Identities = 48/214 (22%), Positives = 84/214 (39%), Gaps = 12/214 (5%)
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
++ A N G+S + ++T+ P PRN +S V + W+EP +N
Sbjct: 398 YQCVAENSAGSS---QASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLAN-TKE 453
Query: 1897 ITNYIIEF-KTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQ 1955
I Y++ K V S +H + +++ F I A G S + S
Sbjct: 454 IIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGAS--SASV 511
Query: 1956 SVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLL-GYNIAIRDVTKTMWM 2014
P+PP PL +R++GS+ + W W A G+ + R +KT +
Sbjct: 512 PTLASTLGEAPAPP--PLSVRVLGSSSLQLLW--EPWPRLAQHEGGFKLFYRPASKTSFT 567
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
+ +N+ L Y +++ A N+ G
Sbjct: 568 GPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHG 601
Score = 43.6 bits (98), Expect = 0.008
Identities = 45/168 (26%), Positives = 68/168 (40%), Gaps = 18/168 (10%)
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLK-------TAKATYENRXXXXXXXXXXXXXXX 1547
P + I L C G P ++TW ++G +L A + R
Sbjct: 55 PGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGD 114
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT---AVIEGIPPPEV 1604
Y+C+A N G V S IQ T+S+ + + VG+E V I G+P P +
Sbjct: 115 YECVAQNRFGLV-VSRKARIQ---AATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLI 170
Query: 1605 IWYKNGNKLENDKE-YNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
W KN ++ D E Y + K V++I L+ + ASN A
Sbjct: 171 TWEKNRVPIDTDNERYTLLPK---GVLQITGLRAEDGGIFHCVASNIA 215
Score = 38.3 bits (85), Expect = 0.30
Identities = 25/86 (29%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV---FPEDAGT 580
G + +C+VEG P +ITW R+ + P + ++ R P D G
Sbjct: 56 GQPIVLDCRVEGTPPVRITW-RKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGD 114
Query: 581 FTCVAKNAAGFASSTTELIVEAPLSD 606
+ CVA+N G S I A +SD
Sbjct: 115 YECVAQNRFGLVVSRKARIQAATMSD 140
Score = 35.1 bits (77), Expect = 2.8
Identities = 34/125 (27%), Positives = 52/125 (41%), Gaps = 5/125 (4%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTS 1986
I I +DE I++ AEN+ G S + +V + +P PP + V S V S
Sbjct: 387 ISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAE--GLPGPPRNVRAV-SVSSTEVRVS 443
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK-VDVNTLKFNIRDLSENHTYMIRIYARN 2045
W P ++GY + IR +E + V +T + + DL + Y I A
Sbjct: 444 WSEP-LANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYT 502
Query: 2046 EIGLS 2050
G S
Sbjct: 503 PRGAS 507
>BC042054-1|AAH42054.1| 814|Homo sapiens putative neuronal cell
adhesion molecule protein.
Length = 814
Score = 84.6 bits (200), Expect = 3e-15
Identities = 79/330 (23%), Positives = 131/330 (39%), Gaps = 33/330 (10%)
Query: 605 SDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPD 664
SD G V A I F P+A +EG +C++ +P+P
Sbjct: 110 SDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL 169
Query: 665 IAWLFKGEEIVPDENISVAIESDMHMYC----SVLKITNVKKFQEGTYTVVAVN----RE 716
I W E V I++D Y VL+IT ++ G + VA N R
Sbjct: 170 ITW----------EKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Query: 717 GEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCK-NNKPV 775
+ V +G + P ++ +++ + ++ +L GNPRP ++W + + +P+
Sbjct: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
Query: 776 KALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAV--ITVEEPTEENAEPP 833
+ G + I+ V+ GVY A +A + V+ P E
Sbjct: 280 GVEGIQVLGTGN--LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAE------ 331
Query: 834 LFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVIT 893
F+ Q I+ T + P P +TW +N +++ P + N L I+
Sbjct: 332 -FVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHV--RLKNNNSTLTIS 388
Query: 894 NVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
+ E D Y+CVA NSAG S AR+T+
Sbjct: 389 GIGPE-DEAIYQCVAENSAGSSQASARLTV 417
Score = 73.3 bits (172), Expect = 9e-12
Identities = 77/303 (25%), Positives = 121/303 (39%), Gaps = 40/303 (13%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G +F+CQ+ G P+P ITW + I + Y L I + ED G F
Sbjct: 152 EGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE---RYTLLPKGVLQITGLRAEDGGIFH 208
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXXADILEGIPPTFSKKPKA 642
CVA N A S HG+ +TV P P+
Sbjct: 209 CVASNIASIRIS------------HGARLTVSGSGSGAYK----------EPAILVGPEN 246
Query: 643 QYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKK 702
+ +LEC P P ++W + E I V + L I++V
Sbjct: 247 LTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQV-------LGTGNLIISDVTV 299
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNP 762
G Y V A NR G + + + + P + ++ +S+ G + + + Q G P
Sbjct: 300 QHSGVY-VCAANRPG-TRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEP 357
Query: 763 RPTITWCKNNK---PVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
P +TW KN + P + K++ T +I+ + P +DE +Y AENS G ++ SA
Sbjct: 358 PPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGP---EDEAIYQCVAENSAGSSQASAR 414
Query: 820 ITV 822
+TV
Sbjct: 415 LTV 417
Score = 67.3 bits (157), Expect = 6e-10
Identities = 83/385 (21%), Positives = 140/385 (36%), Gaps = 15/385 (3%)
Query: 636 FSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVL 695
F+ +P G I+L+CR+ P I W G E+ P+ S + + M
Sbjct: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVEL-PESTHSTLLANGSLMIRHFR 102
Query: 696 KITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILS 755
EG Y VA NR G L + K + ++ + +G
Sbjct: 103 LEPGGSPSDEGDYECVAQNRFG---LVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQ 159
Query: 756 AQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGI-A 814
Q+ G P+P ITW KN P+ + + + + +D G++ A N I
Sbjct: 160 CQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Query: 815 ETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIIS 874
A +TV + P + + +T+ T L T NP P ++W R +
Sbjct: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
Query: 875 PSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVE-KVTFVKH 933
E I G L+I++V + SG Y C A+ + A+ + V+ FV+H
Sbjct: 280 GVEGIQVLGTG---NLIISDVTVQ-HSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQH 335
Query: 934 LQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXXXXX 991
Q S G T + CQ W N + + H + +
Sbjct: 336 PQ-SISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRL--KNNNSTLTISGIGP 392
Query: 992 XDVGVIKCIVKDQETSTMLVVKETI 1016
D + +C+ ++ S+ + T+
Sbjct: 393 EDEAIYQCVAENSAGSSQASARLTV 417
Score = 65.7 bits (153), Expect = 2e-09
Identities = 67/297 (22%), Positives = 112/297 (37%), Gaps = 17/297 (5%)
Query: 1480 QSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYR-DGKKLKTAKATYENRXXXXXX 1538
+ P + +N+T ++ L C+ G P+P V+W R DG+ +
Sbjct: 236 KEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIIS 295
Query: 1539 XXXXXXXXXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKV----GDEWLVTA 1594
Y C A V + Q + V+ E ++ + G + T
Sbjct: 296 DVTVQHSGVYVCAANRPGTRVRRTA----QGRLVVQAPAEFVQHPQSISRPAGTTAMFTC 351
Query: 1595 VIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS 1654
+G PPP V W KNG L ++ K S + I + + Y A N+AG+S
Sbjct: 352 QAQGEPPPHVTWLKNGQVL--GPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSS 409
Query: 1655 SVEVTLKVYDKPSKPEGPVIMREISRES--VTIEWKPPLDDGGLELTKYAIEKHEPDNNR 1712
L V P P +R +S S V + W PL + E+ Y + + +
Sbjct: 410 QASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLAN-TKEIIGYVLHIRKAADPP 468
Query: 1713 WIKVAD-VDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPS 1768
++ + V + + + L + Y F + A P G S A S P + T + P+
Sbjct: 469 ELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSA--SVPTLASTLGEAPA 523
Score = 63.3 bits (147), Expect = 9e-09
Identities = 45/192 (23%), Positives = 85/192 (44%), Gaps = 9/192 (4%)
Query: 1283 VVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKS 1342
VV+ P + V + + G+ Q P P+ W+ N +++ H + + + +
Sbjct: 325 VVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVR--LKNNN 382
Query: 1343 ASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTIL---DKPSPPGKPNILEIDSSSINI 1399
++LTI + D IY+ EN+ G + +T+L P PP + + S+ + +
Sbjct: 383 STLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRV 442
Query: 1400 CWDEPENTGNSTIIYYVVEYQE-IDTTEWISVKNITKT--QTSIQNLKTNSSYRFRAYAV 1456
W EP II YV+ ++ D E + ++K+ Q + +L+ +++Y F A
Sbjct: 443 SWSEP-LANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAY 501
Query: 1457 NEVDISDASETT 1468
S AS T
Sbjct: 502 TPRGASSASVPT 513
Score = 62.1 bits (144), Expect = 2e-08
Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 3/89 (3%)
Query: 512 FVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIR 571
FV+ + P G+T F CQ +G P P +TW + ++ P ++ +N +TL I
Sbjct: 332 FVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRL---KNNNSTLTIS 388
Query: 572 EVFPEDAGTFTCVAKNAAGFASSTTELIV 600
+ PED + CVA+N+AG + ++ L V
Sbjct: 389 GIGPEDEAIYQCVAENSAGSSQASARLTV 417
Score = 48.8 bits (111), Expect = 2e-04
Identities = 48/214 (22%), Positives = 84/214 (39%), Gaps = 12/214 (5%)
Query: 1837 FRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSP 1896
++ A N G+S + ++T+ P PRN +S V + W+EP +N
Sbjct: 398 YQCVAENSAGSS---QASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLAN-TKE 453
Query: 1897 ITNYIIEF-KTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQ 1955
I Y++ K V S +H + +++ F I A G S + S
Sbjct: 454 IIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGAS--SASV 511
Query: 1956 SVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLL-GYNIAIRDVTKTMWM 2014
P+PP PL +R++GS+ + W W A G+ + R +KT +
Sbjct: 512 PTLASTLGEAPAPP--PLSVRVLGSSSLQLLW--EPWPRLAQHEGGFKLFYRPASKTSFT 567
Query: 2015 EVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
+ +N+ L Y +++ A N+ G
Sbjct: 568 GPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHG 601
Score = 43.6 bits (98), Expect = 0.008
Identities = 45/168 (26%), Positives = 68/168 (40%), Gaps = 18/168 (10%)
Query: 1495 PNEDIELTCIFGGVPQPKVTWYRDGKKLK-------TAKATYENRXXXXXXXXXXXXXXX 1547
P + I L C G P ++TW ++G +L A + R
Sbjct: 55 PGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGD 114
Query: 1548 YKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVT---AVIEGIPPPEV 1604
Y+C+A N G V S IQ T+S+ + + VG+E V I G+P P +
Sbjct: 115 YECVAQNRFGLV-VSRKARIQ---AATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLI 170
Query: 1605 IWYKNGNKLENDKE-YNITTKEKTSVIRIKELKRSHSSKYTIEASNTA 1651
W KN ++ D E Y + K V++I L+ + ASN A
Sbjct: 171 TWEKNRVPIDTDNERYTLLPK---GVLQITGLRAEDGGIFHCVASNIA 215
Score = 38.3 bits (85), Expect = 0.30
Identities = 25/86 (29%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREV---FPEDAGT 580
G + +C+VEG P +ITW R+ + P + ++ R P D G
Sbjct: 56 GQPIVLDCRVEGTPPVRITW-RKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGD 114
Query: 581 FTCVAKNAAGFASSTTELIVEAPLSD 606
+ CVA+N G S I A +SD
Sbjct: 115 YECVAQNRFGLVVSRKARIQAATMSD 140
Score = 35.1 bits (77), Expect = 2.8
Identities = 34/125 (27%), Positives = 52/125 (41%), Gaps = 5/125 (4%)
Query: 1927 IENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTS 1986
I I +DE I++ AEN+ G S + +V + +P PP + V S V S
Sbjct: 387 ISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAE--GLPGPPRNVRAV-SVSSTEVRVS 443
Query: 1987 WGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGK-VDVNTLKFNIRDLSENHTYMIRIYARN 2045
W P ++GY + IR +E + V +T + + DL + Y I A
Sbjct: 444 WSEP-LANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYT 502
Query: 2046 EIGLS 2050
G S
Sbjct: 503 PRGAS 507
>AY358367-1|AAQ88733.1| 625|Homo sapiens YVTM2421 protein.
Length = 625
Score = 84.6 bits (200), Expect = 3e-15
Identities = 102/384 (26%), Positives = 155/384 (40%), Gaps = 25/384 (6%)
Query: 1635 LKRSHSSKYTIEASNTAGTSSVEVTLK-VYDKPSKPEGPVIMREISRESVTIEWKPPLD- 1692
+K++ + SN + E+ +K V D S E P + I +V + W PP+
Sbjct: 240 IKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSN-IQARAVVLSWAPPVGL 298
Query: 1693 ----DGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYC-IQKLNENCEYMFRVIAQ-NP 1746
GL Y+ E D R K + E C ++ L +Y RV A N
Sbjct: 299 SCGPHSGLSFP-YSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNS 357
Query: 1747 VGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEI 1806
V S SEP+ T P S+ + W NG S I +Y +E
Sbjct: 358 VKGSC---SEPVSFTTHSCAPECPFPPKLAHR-SKSSLTLQWKAPIDNG-SKITNYLLEW 412
Query: 1807 KQEGKK---WKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTL 1863
EGK+ ++ ++ KL Y FR+ ARN+IGTS T+G
Sbjct: 413 -DEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIP 471
Query: 1864 TPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVH 1923
PS PR + + VTL+W++PE + Y +E + + + G +
Sbjct: 472 QMPSAPR---LVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDL- 527
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++N+K + FR++A NT G S P+E P PPT PL V S+
Sbjct: 528 TCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDR--PGPPTRPLVKGPVTSHGF 585
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRD 2007
W P+ +GG+ +L Y + I D
Sbjct: 586 SVKWDPPKDNGGSEILKYLLEITD 609
Score = 80.2 bits (189), Expect = 7e-14
Identities = 71/293 (24%), Positives = 124/293 (42%), Gaps = 13/293 (4%)
Query: 1616 DKEYNITTKEKTSVIRIKELKRSHSSKYTIEA--SNTAGTSSVEVTLKVYDKPSKPEGPV 1673
D +Y I + +K+L+ + + A ++ G+ S V+ + + P
Sbjct: 322 DGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPP 381
Query: 1674 IMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYC-IQKLN 1732
+ S+ S+T++WK P+D+G ++T Y +E E N + + +C + KL
Sbjct: 382 KLAHRSKSSLTLQWKAPIDNGS-KITNYLLEWDEGKRNSGFRQCFFGS--QKHCKLTKLC 438
Query: 1733 ENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSE 1792
Y FR+ A+N +G S S+ +V T ++P V + W E
Sbjct: 439 PAMGYTFRLAARNDIGTSGY--SQEVVCYTLGNIPQMPSAPRLVRA-GITWVTLQWSKPE 495
Query: 1793 KNGGSPIIDYKVEIKQEGKK--WKXXXXXXXXXARIQKLSINTTYQFRIYARNEIGTSLP 1850
+I Y +EI+++ + ++ L +T Y+FR+ A N G S P
Sbjct: 496 GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 555
Query: 1851 YTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE 1903
T PP++P V TS ++KW P+ NGGS I Y++E
Sbjct: 556 SEVLVCTTSPDRPGPPTRP--LVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 606
Score = 65.7 bits (153), Expect = 2e-09
Identities = 38/112 (33%), Positives = 56/112 (50%), Gaps = 4/112 (3%)
Query: 1597 EGIPPPEVIWYK-NGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTS- 1654
EG P EVI Y + END ++ + +K LKRS K+ + ASNT G S
Sbjct: 495 EGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSC 554
Query: 1655 --SVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIE 1704
V V D+P P P++ ++ +++W PP D+GG E+ KY +E
Sbjct: 555 PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE 606
Score = 45.6 bits (103), Expect = 0.002
Identities = 29/113 (25%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 1358 YKLRLENNCGHADVEMNV---TILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIY 1414
++L N+ G + V T+ + P P P ++ + + + W +PE +I
Sbjct: 445 FRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT 504
Query: 1415 YVVEYQEIDTTEWISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASE 1466
Y +E QE + K + T +++NLK ++ Y+FR A N S SE
Sbjct: 505 YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 557
Score = 41.9 bits (94), Expect = 0.024
Identities = 22/87 (25%), Positives = 44/87 (50%), Gaps = 4/87 (4%)
Query: 1336 PSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA---DVEMNVTILDKPSPPGKPNIL-E 1391
P + + T+K ++ + ++L N G + +V + T D+P PP +P +
Sbjct: 520 PKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGP 579
Query: 1392 IDSSSINICWDEPENTGNSTIIYYVVE 1418
+ S ++ WD P++ G S I+ Y++E
Sbjct: 580 VTSHGFSVKWDPPKDNGGSEILKYLLE 606
>AC007567-1|AAS07434.1| 383|Homo sapiens unknown protein.
Length = 383
Score = 84.2 bits (199), Expect = 5e-15
Identities = 72/304 (23%), Positives = 136/304 (44%), Gaps = 23/304 (7%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 45 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 161
Query: 751 SVILSAQV-VGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 162 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 218
Query: 804 TLKAENSEGIAETSAV-ITVEEPTEENAEPPLFINRFQEITVKE--KGTIKLVARVTRN- 859
+ +++ I + + + V PP F+ + KE +G + + +
Sbjct: 219 YARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGL 278
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P I W + + ++ + T+ +NF+ L I +V SE DSG+Y+C+A N+ G H
Sbjct: 279 PTPIIYWAKEDGMLPKNRTVYKNFEKT---LQIIHV-SEADSGNYQCIAKNALGAIHHTI 334
Query: 920 RVTI 923
V +
Sbjct: 335 SVRV 338
Score = 51.6 bits (118), Expect = 3e-05
Identities = 41/147 (27%), Positives = 70/147 (47%), Gaps = 14/147 (9%)
Query: 633 PPTF-SKKPKAQYVDE--GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
PPTF + + A +E G+ + LEC +P P I W K + ++P +N +V +
Sbjct: 248 PPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWA-KEDGMLP-KNRTVYKNFE-- 303
Query: 690 MYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQG 749
L+I +V + G Y +A N G I +++K P I +++++ G
Sbjct: 304 ---KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA----PYWITAPQNLVLSPG 356
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVK 776
E L + GNP+P I+W N P++
Sbjct: 357 EDGTLICRANGNPKPRISWLTNGVPIE 383
Score = 47.6 bits (108), Expect = 5e-04
Identities = 71/358 (19%), Positives = 131/358 (36%), Gaps = 18/358 (5%)
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYE-REYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIK 1329
L+ KL ++V+ PP I ++Y I ++ + + + P P+ W N
Sbjct: 30 LEVPLDPKLLEDLVQ-PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFD 88
Query: 1330 KCKHT----KPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPG 1385
K KP + ++ + T G+Y+ N G A V N+ + SP
Sbjct: 89 IDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAA-VSNNIVVRPSRSPLW 147
Query: 1386 KPNILE---IDSSSINICWDEPENTGNSTIIYYVVE-YQEIDTTEWISVK-NITKTQTSI 1440
LE + S + P II+++ +Q + +E +S N +++
Sbjct: 148 TKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNV 207
Query: 1441 QNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN---E 1497
T Y A + I + K ++ + PT P N + +
Sbjct: 208 LPEDTREDYICYARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGN 267
Query: 1498 DIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDH 1556
+ L CI G+P P + W ++ L + Y+N Y+CIA N
Sbjct: 268 VLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNAL 327
Query: 1557 GEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLE 1614
G + + V ++ P + +++ G++ + G P P + W NG +E
Sbjct: 328 GAIHHTISVRVKAAPYWITAPQNLVL--SPGEDGTLICRANGNPKPRISWLTNGVPIE 383
Score = 46.8 bits (106), Expect = 9e-04
Identities = 46/230 (20%), Positives = 88/230 (38%), Gaps = 13/230 (5%)
Query: 645 VDEGSDILLECRL-VAIPEPDIAWLFKGEEIVPD-ENISVAIESDMHMYCSVLKITNVKK 702
+ G ++L CR + +P P I W+ + +P E +S + D++ + + T
Sbjct: 157 LQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDY 216
Query: 703 FQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQ---GESVILSAQVV 759
+ ++ + V+ K+ + PP + P + ++ G + L
Sbjct: 217 ICYARFNHTQTIQQKQPISVKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAE 276
Query: 760 GNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAV 819
G P P I W K + + T ++ I+ + D G Y A+N+ G +
Sbjct: 277 GLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEA-DSGNYQCIAKNALGAIHHTIS 335
Query: 820 ITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN 869
+ V+ P +I Q + + L+ R NP P I+W N
Sbjct: 336 VRVKAA-------PYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTN 378
Score = 46.4 bits (105), Expect = 0.001
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 479 NYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVE-KLRPKHTPDGSTVQFECQVEGYP 537
N+TQ +Q+K + I + V +S E+ + E K G+ + EC EG P
Sbjct: 223 NHTQTIQQK--QPIS-VKVISAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 279
Query: 538 RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTE 597
P I W ++ ++ ++ ++ TL I V D+G + C+AKNA G T
Sbjct: 280 TPIIYWAKEDGMLPKNRTVYKNFEK----TLQIIHVSEADSGNYQCIAKNALGAIHHTIS 335
Query: 598 LIVEA 602
+ V+A
Sbjct: 336 VRVKA 340
>AB011422-1|BAA76314.1| 1289|Homo sapiens Trad protein.
Length = 1289
Score = 84.2 bits (199), Expect = 5e-15
Identities = 58/178 (32%), Positives = 87/178 (48%), Gaps = 11/178 (6%)
Query: 1586 VGDEWLVTAVIEGIPPPEVIWY-KNGNKLENDKE---YNITTKEKTSV-IRIKELKRSHS 1640
+GD ++ + G P P + W + N L+ D Y +++ + + ++I L S
Sbjct: 787 LGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS 846
Query: 1641 SKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTK 1700
YT A+N GT+S T+KV P+ P P I +E S SV + W PP G ++
Sbjct: 847 GIYTCIATNDHGTTSTSATVKVQGVPAAPNRP-IAQERSCTSVILRWLPPSSTGNCTISG 905
Query: 1701 YAIEKHEPDNNRWIKVADVDRDVETYC-IQKLNENCEYMFRVIAQNPVGFSEALESEP 1757
Y +E E + W + V ++TY I+ L+ C Y FRV A NP G S L SEP
Sbjct: 906 YTVEYREEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGIS--LPSEP 959
Score = 72.9 bits (171), Expect = 1e-11
Identities = 46/142 (32%), Positives = 68/142 (47%), Gaps = 1/142 (0%)
Query: 1333 HTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEI 1392
+T S DS +L I + D+GIY N+ G V + P+ P +P E
Sbjct: 824 YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER 883
Query: 1393 DSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRF 1451
+S+ + W P +TGN TI Y VEY+E + W SV + T I++L Y+F
Sbjct: 884 SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF 943
Query: 1452 RAYAVNEVDISDASETTEYYKV 1473
R A N IS SE +E+ ++
Sbjct: 944 RVSASNPWGISLPSEPSEFVRL 965
Score = 55.6 bits (128), Expect = 2e-06
Identities = 36/120 (30%), Positives = 61/120 (50%), Gaps = 5/120 (4%)
Query: 1845 IGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEF 1904
I T+ T+ T+ K P+ P + E + SV L+W P S G I+ Y +E+
Sbjct: 852 IATNDHGTTSTSATV-KVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEY 910
Query: 1905 KTVKGKSWTKIVTVGGSVHEH-CIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKH 1962
+ + W + +V ++ + IE++ FR+SA N G+SLP+E S+ VRL ++
Sbjct: 911 REEGSQIWQQ--SVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEY 968
Score = 52.0 bits (119), Expect = 2e-05
Identities = 32/96 (33%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 735 PQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPV------KALPTKSDGDTHS 788
P+ + PL + G++VIL +V G P+PTITW ++ + A T S D+
Sbjct: 774 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 833
Query: 789 ITI-LKPKKVKDEGVYTLKAENSEGIAETSAVITVE 823
IT+ + +D G+YT A N G TSA + V+
Sbjct: 834 ITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 869
Score = 50.8 bits (116), Expect = 5e-05
Identities = 32/100 (32%), Positives = 48/100 (48%), Gaps = 4/100 (4%)
Query: 506 QSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYD---- 561
Q +AP F+ L G TV +C+V G P+P ITW I + + Y
Sbjct: 770 QEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSC 829
Query: 562 DDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVE 601
D TL I + P+D+G +TC+A N G S++ + V+
Sbjct: 830 DSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQ 869
Score = 46.4 bits (105), Expect = 0.001
Identities = 37/142 (26%), Positives = 64/142 (45%), Gaps = 8/142 (5%)
Query: 1929 NIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWG 1988
N+ +D I+ A N G + + S +V+++ VP+ P P+ +++++ W
Sbjct: 840 NLMPQDSGIYTCIATNDHGTT--STSATVKVQG---VPAAPNRPIAQERSCTSVILR-WL 893
Query: 1989 TPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIG 2048
P G + GY + R+ +W + ++T I DLS Y R+ A N G
Sbjct: 894 PPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLV-IEDLSPGCPYQFRVSASNPWG 952
Query: 2049 LSEPLESDEPFKVIPGEGSHAD 2070
+S P E E F +P + AD
Sbjct: 953 ISLPSEPSE-FVRLPEYDAAAD 973
Score = 44.0 bits (99), Expect = 0.006
Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 2/70 (2%)
Query: 1783 SVYITWFPSEKNGGSPIIDYKVEIKQEGKK-W-KXXXXXXXXXARIQKLSINTTYQFRIY 1840
SV + W P G I Y VE ++EG + W + I+ LS YQFR+
Sbjct: 887 SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVS 946
Query: 1841 ARNEIGTSLP 1850
A N G SLP
Sbjct: 947 ASNPWGISLP 956
Score = 43.6 bits (98), Expect = 0.008
Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 1/97 (1%)
Query: 648 GSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE-SDMHMYCSVLKITNVKKFQEG 706
G ++L+C++ P+P I W + I+ +N S S LKI N+ G
Sbjct: 788 GDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSG 847
Query: 707 TYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKS 743
YT +A N G S +K++ P + I +S
Sbjct: 848 IYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERS 884
Score = 41.5 bits (93), Expect = 0.032
Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 6/96 (6%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEII----SPSETIT-QNFDGEN 887
P F+ ++T T+ L +V P P+ITW ++ I + S T T + D
Sbjct: 774 PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGE 833
Query: 888 IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
I L I N+ + DSG Y C+A+N G +S A V +
Sbjct: 834 ITLKICNLMPQ-DSGIYTCIATNDHGTTSTSATVKV 868
>EF506611-1|ABP88252.1| 1248|Homo sapiens non-neural L1CAM protein.
Length = 1248
Score = 83.4 bits (197), Expect = 8e-15
Identities = 125/577 (21%), Positives = 216/577 (37%), Gaps = 50/577 (8%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PP +++ P+ V DI L+C PE W G P E + V + H
Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88
Query: 692 CSVLKITN---VKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVR 747
+ N ++FQ G Y A N+ G A S I L + K P + ++P++ V
Sbjct: 89 SFTITGNNSNFAQRFQ-GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE---VE 144
Query: 748 QGESVILSAQVVGNPRPTITWCKNNK--PVKALPTKSDGDTHSITILKPKKVKDEGVYTL 805
+GESV+L + P + N+K +K + G ++ + Y
Sbjct: 145 EGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 204
Query: 806 KAE--NSEGIAETSAVITVEEPTEE--NAEPPLFI--NRFQEITVKEKGTIKLVARVTRN 859
A + I + + + T + +P L N + + + L
Sbjct: 205 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 264
Query: 860 PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGA 919
P P+I W R + P + N L + V E D G+Y+C+A NS G + H
Sbjct: 265 PTPTIKWLRPS---GPMPADRATYQNHNKTLQLLKVGEE-DDGEYRCLAENSLGSARHAY 320
Query: 920 RVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTK--WYHNKKEISGM--DHREI 975
VT VE + H +S+ G+T L+CQ + W N + + D +
Sbjct: 321 YVT--VEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYR 378
Query: 976 IQEGRXXXXXXXXXXXXDVGVIKCIVKDQE-----TSTMLVVKETIPEFIRKLQDFEVKE 1030
IQ G D V +C +++ + + VV+ Q + +
Sbjct: 379 IQRG---ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ 435
Query: 1031 KDVAILEVE-INSETADVVW-ERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYS 1088
A L + + V W + DG + + + + L IR+ +D G Y
Sbjct: 436 GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYAN----GTLGIRDLQANDTGRYF 491
Query: 1089 CILRDESCTAEVTV---VELPPEIITRLQNQKVNKGNKATFEIELTKGDAL---VRWFKD 1142
C+ ++ + V +I ++ KG++ TF + + +L + W D
Sbjct: 492 CLAANDQNNVTIMANLKVTDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGD 551
Query: 1143 GSEIQ-FSNHIQLTIDGKKQKLKIYDCDLDDAGEYSC 1178
G ++Q + + I+ +L I+ D D G YSC
Sbjct: 552 GRDLQELGDSDKYFIE--DGRLVIHSLDYSDQGNYSC 586
Score = 76.6 bits (180), Expect = 9e-13
Identities = 112/488 (22%), Positives = 192/488 (39%), Gaps = 47/488 (9%)
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEP-DIAWL-FKGEEIVPDENISVAIESD 687
EG P + K V+EG ++L C EP I W+ K I DE +++ +
Sbjct: 128 EGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGN 187
Query: 688 MHMYCSVLKITNVKKFQ-----EGTYTVVAVNREGEASLPIVLKIKTGEK---EPPQVIE 739
++ + +VL N + GT T++ +E PI L++K P+++
Sbjct: 188 LY-FANVLTSDNHSDYICHAHFPGTRTII--QKE-----PIDLRVKATNSMIDRKPRLLF 239
Query: 740 PLKS---MIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKK 796
P S ++ QG+ ++L G P PTI W + + P+ A ++ +LK +
Sbjct: 240 PTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRATYQNHNKTLQLLKVGE 299
Query: 797 VKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARV 856
+D+G Y AENS G A + +TVE P ++++ Q T +L +V
Sbjct: 300 -EDDGEYRCLAENSLGSARHAYYVTVE-------AAPYWLHKPQSHLYGPGETARLDCQV 351
Query: 857 TRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSS 916
P P +TW R N I Q + + L+++NV D+ +C A N G
Sbjct: 352 QGRPQPEVTW-RINGIPVEELAKDQKYRIQRGALILSNVQPS-DTMVTQCEARNRHGLLL 409
Query: 917 HGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQT--SHTVSTKWYHNKKEISGMDHRE 974
A + + + ++Y +G T L C+ + S +W D R
Sbjct: 410 ANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 469
Query: 975 IIQEGRXXXXXXXXXXXXDVGVIKCI-VKDQETSTMLV-VKETIPEFIRKLQDFEVKEKD 1032
D G C+ DQ T++ +K T I + +++K
Sbjct: 470 FPYAN--GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVTDATQITQGPRSTIEKKG 527
Query: 1033 VAI---LEVEIN-SETADVVWERDGEIIKP--KKNKYDFEKRGHIRKLYIRNTSVHDEGE 1086
+ + + S + W DG ++ +KY E +L I + D+G
Sbjct: 528 SRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED----GRLVIHSLDYSDQGN 583
Query: 1087 YSCILRDE 1094
YSC+ E
Sbjct: 584 YSCVASTE 591
Score = 64.9 bits (151), Expect = 3e-09
Identities = 142/729 (19%), Positives = 273/729 (37%), Gaps = 51/729 (6%)
Query: 1068 RGHIRKLYIRNTSVHDEGEYSCILRDESCTAE---VTVVELPPEIITRLQNQKVNKGNKA 1124
+ H + L + D+GEY C+ + +A VE P + + Q+ G A
Sbjct: 286 QNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETA 345
Query: 1125 TFEIELT-KGDALVRWFKDGSEI-QFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGN 1182
+ ++ + V W +G + + + + I ++ L + + D CE N
Sbjct: 346 RLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI--QRGALILSNVQPSDTMVTQCEARN 403
Query: 1183 S-----KCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKK--KSV 1235
I V+ P+ T ++ V +T L V W + +V
Sbjct: 404 RHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV 463
Query: 1236 IEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTTKLKVEV-VEFPPKIVDYE 1294
++D F + TL IR +D Y C+ + ++ + + V +I
Sbjct: 464 LQDERFFPYANG----TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVTDATQITQGP 519
Query: 1295 REYRIKRGSDVTLLVDYQAFP--QPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVEN 1352
R K+GS VT P QP+ W + + +++ + + L I ++
Sbjct: 520 RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYF-IEDGRLVIHSLDY 578
Query: 1353 TDAGIYKLRLENNCGHADVEMNVTILDKPSPPGK---PNILEIDSSSINICWDEPENTGN 1409
+D G Y + + ++ P P + ++ + S + + W P N
Sbjct: 579 SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSW-SPAEDHN 637
Query: 1410 STIIYYVVEYQ--EIDTTEWISVKNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASE 1466
+ I Y +E++ E+ +W S+ + QTS L Y FR A+N+ + S
Sbjct: 638 APIEKYDIEFEDKEMAPGKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSP 697
Query: 1467 TTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIE-LTCIFGGVPQP--KVTWYRDGKKLK 1523
+E + ++P K N TT + L + PQ +V W G +
Sbjct: 698 VSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGP 757
Query: 1524 TAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGE-VETSCVVGIQ----QKPVITISNE 1578
+ + K A N G+ E +G + + +
Sbjct: 758 WQEQIVSD-PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGI 816
Query: 1579 DIKQKHKVGDEW--LVTAVIEG-IPPPEVIWYKNGNKLENDKEY----NITTKEKTSVIR 1631
+I V +W + A ++G + V +++ G++ ++ K + ++ T+ +
Sbjct: 817 EILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI 876
Query: 1632 IKELKRSHSSKYTIEASNTAGTS-SVEVTLKVYD-KPSKPEGPVIMREISRESVTIEWKP 1689
+ L+ S ++A N G+ + E T + P PE + + S S+ + W+P
Sbjct: 877 LSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEA-LHLECQSNTSLLLRWQP 935
Query: 1690 PLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVE--TYCIQKLNENCEYMFRVIAQNPV 1747
PL G+ LT Y + H D +++ RD E T+ + L+ + Y F++ A
Sbjct: 936 PLSHNGV-LTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKE 994
Query: 1748 GFSEALESE 1756
G EA+ E
Sbjct: 995 GPGEAIVRE 1003
Score = 51.2 bits (117), Expect = 4e-05
Identities = 40/176 (22%), Positives = 69/176 (39%), Gaps = 10/176 (5%)
Query: 1497 EDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFND 1555
+ + L CI G P P + W R + +ATY+N Y+C+A N
Sbjct: 253 QPLVLECIAEGFPTPTIKWLRPSGPMPADRATYQNHNKTLQLLKVGEEDDGEYRCLAENS 312
Query: 1556 HGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNG---NK 1612
G + V ++ P ++ + G+ + ++G P PEV W NG +
Sbjct: 313 LGSARHAYYVTVEAAPYWL--HKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEE 370
Query: 1613 LENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
L D++Y I + + + ++ S + EA N G + V P+K
Sbjct: 371 LAKDQKYRI----QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAK 422
Score = 46.0 bits (104), Expect = 0.001
Identities = 27/79 (34%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTC 583
G + EC EG+P P I W R + P + Y + N TL + +V ED G + C
Sbjct: 252 GQPLVLECIAEGFPTPTIKWLRPSG---PMPADRATYQNHN-KTLQLLKVGEEDDGEYRC 307
Query: 584 VAKNAAGFASSTTELIVEA 602
+A+N+ G A + VEA
Sbjct: 308 LAENSLGSARHAYYVTVEA 326
Score = 41.9 bits (94), Expect = 0.024
Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 509 APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATL 568
AP ++ K + G T + +CQV+G P+P++TW ++ Q Y L
Sbjct: 327 APYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GAL 384
Query: 569 VIREVFPEDAGTFTCVAKNAAGFASSTTEL-IVEAP 603
++ V P D C A+N G + + +V+ P
Sbjct: 385 ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 420
Score = 39.5 bits (88), Expect = 0.13
Identities = 25/79 (31%), Positives = 35/79 (44%), Gaps = 4/79 (5%)
Query: 524 GSTVQFECQVEGYP--RPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V F CQ P +P ITW ++ D Y+ +D LVI + D G +
Sbjct: 527 GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG--RLVIHSLDYSDQGNY 584
Query: 582 TCVAKNAAGFASSTTELIV 600
+CVA S +L+V
Sbjct: 585 SCVASTELDVVESRAQLLV 603
Score = 33.5 bits (73), Expect = 8.5
Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 1/51 (1%)
Query: 1474 IKETKIQSPTV-EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLK 1523
I E ++ P + E+ + + P +DI L C G P+ + W RDG K
Sbjct: 22 IPEELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFK 72
>AK125322-1|BAC86128.1| 1685|Homo sapiens protein ( Homo sapiens cDNA
FLJ43332 fis, clone NT2RI3006340, highly similar to
Myomesin 1. ).
Length = 1685
Score = 83.4 bits (197), Expect = 8e-15
Identities = 97/407 (23%), Positives = 159/407 (39%), Gaps = 31/407 (7%)
Query: 1669 PEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKV-ADVDRDVETYC 1727
P + + E +R V + WKPP G E Y +EK E W +V ++ +
Sbjct: 640 PPTDLSVTEATRSYVVLSWKPP-GQRGHEGIMYFVEKCEAGTENWQRVNTELPVKSPRFA 698
Query: 1728 IQKLNENCEYMFRVIAQNPVGFSEALE-SEPIVIKTALDVPSXXXXXXXXXXIDNESVYI 1786
+ L E Y FRV N G E E +E V+ LD+P D SV +
Sbjct: 699 LFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDT-SVVV 757
Query: 1787 TWFPSEKNGGSPIIDYKVEIKQEGK-KWKXXXXXXXXXARI--QKLSINTTYQFRIYARN 1843
+W E ++ Y +E G KW+ +R L +Y FR+ A N
Sbjct: 758 SW--EESKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVN 815
Query: 1844 EIGTSLPYTSDD-----KITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPIT 1898
G S Y+ D K IG ++P P +S+ + E++ +
Sbjct: 816 AAGLS-EYSQDSEAIEVKAAIGGGVSPDVCP---ALSDEPGGLTASRGRVHEASPPTFQK 871
Query: 1899 NYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVR 1958
+ ++ K K + +G + E ++E+ + +A S P + ++ R
Sbjct: 872 DALLGSKPNKPSLPSSSQNLGQTEVSKVSETVQEELTPPPQKAAPQGKSKSDPLKKKTDR 931
Query: 1959 LEKHATVPSPPTAPLEIRMVGS--NIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTM---W 2013
+PP+ P +I + S + ++ W P+ GGA + GY + R+V + W
Sbjct: 932 --------APPSPPCDITCLESFRDSMVLGWKQPDKTGGAEITGYYVNYREVIDGVPGKW 983
Query: 2014 MEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFK 2060
E V+ + I + EN Y ++ A N GL P E FK
Sbjct: 984 REANVKAVSEEAYKISNSKENMVYQFQVAAMNMAGLGAPSAVSECFK 1030
Score = 69.3 bits (162), Expect = 1e-10
Identities = 52/209 (24%), Positives = 85/209 (40%), Gaps = 10/209 (4%)
Query: 1754 ESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQ--EGK 1811
+S+P+ KT PS +S+ + W +K GG+ I Y V ++ +G
Sbjct: 921 KSDPLKKKTDRAPPSPPCDITCLESF-RDSMVLGWKQPDKTGGAEITGYYVNYREVIDGV 979
Query: 1812 --KWKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGK-TLTPP 1866
KW+ +I N YQF++ A N G P + + T+ P
Sbjct: 980 PGKWREANVKAVSEEAYKISNSKENMVYQFQVAAMNMAGLGAPSAVSECFKCEEWTIAVP 1039
Query: 1867 SQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGK--SWTKIVTVGGSVHE 1924
P + SE S+ L+W P +G +P+T Y ++ K K K W +
Sbjct: 1040 GPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNVY 1099
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTE 1953
+ +KE +FR+ A N GV P++
Sbjct: 1100 LKVRGLKEGVSYVFRVRAINQAGVGKPSD 1128
Score = 66.1 bits (154), Expect = 1e-09
Identities = 34/114 (29%), Positives = 56/114 (49%), Gaps = 3/114 (2%)
Query: 1963 ATVPSPPTAPLEIRMVGSN--IVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVD 2020
A + P APL+++ + +N ++ SW P DGG+P+LGY I +V W +
Sbjct: 504 AEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTP 563
Query: 2021 VNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVI-PGEGSHADEEP 2073
V +F + L E +Y+ R+ A N++G+ P EP + P E + P
Sbjct: 564 VKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRP 617
Score = 62.1 bits (144), Expect = 2e-08
Identities = 52/234 (22%), Positives = 91/234 (38%), Gaps = 9/234 (3%)
Query: 1626 KTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTI 1685
+T V ++ E + + +A+ + S + K P P + E R+S+ +
Sbjct: 893 QTEVSKVSETVQEELTPPPQKAAPQGKSKSDPLKKKTDRAPPSPPCDITCLESFRDSMVL 952
Query: 1686 EWKPPLDDGGLELTKYAIEKHEPDN---NRWIKVADVDRDVETYCIQKLNENCEYMFRVI 1742
WK P GG E+T Y + E + +W + E Y I EN Y F+V
Sbjct: 953 GWKQPDKTGGAEITGYYVNYREVIDGVPGKWREANVKAVSEEAYKISNSKENMVYQFQVA 1012
Query: 1743 AQNPVGF-SEALESEPIVIKTALDVPSXXXXXXXXXXIDNESVYITWFPSEKNGGSPIID 1801
A N G + + SE + + +S+ + W P +G +P+
Sbjct: 1013 AMNMAGLGAPSAVSECFKCEEWTIAVPGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTG 1072
Query: 1802 YKVEIKQEGKK---WKXXXXXXXXXA--RIQKLSINTTYQFRIYARNEIGTSLP 1850
Y V++K+ K W+ +++ L +Y FR+ A N+ G P
Sbjct: 1073 YFVDLKEAKAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKP 1126
Score = 61.7 bits (143), Expect = 3e-08
Identities = 49/198 (24%), Positives = 79/198 (39%), Gaps = 6/198 (3%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVT-VGGSVHE 1924
P P + V+E+T V L W P G I Y +E ++W ++ T +
Sbjct: 638 PGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIM-YFVEKCEAGTENWQRVNTELPVKSPR 696
Query: 1925 HCIENIKEKDEIIFRISAENTVGVSLPTESQSVR-LEKHATVPSPPTAPLEIRMVGSNIV 1983
+ ++ E FR+ N+ GV P+E+ V + +P P + R +++V
Sbjct: 697 FALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVV 756
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYA 2043
+ SW E L+GY I W V +F L +Y+ R+ A
Sbjct: 757 V-SW--EESKDAKELVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRA 813
Query: 2044 RNEIGLSEPLESDEPFKV 2061
N GLSE + E +V
Sbjct: 814 VNAAGLSEYSQDSEAIEV 831
Score = 61.3 bits (142), Expect = 4e-08
Identities = 43/164 (26%), Positives = 69/164 (42%), Gaps = 7/164 (4%)
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLK 1661
PE+ WY+NG L K + + + L + YTI +
Sbjct: 439 PEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVF 498
Query: 1662 VYDKPSKPEG----PVIMR--EISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIK 1715
V D ++ EG P+ ++ E +++ + I WK P DGG + Y I+K E + W +
Sbjct: 499 VRDADAEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQ 558
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFS-EALESEPI 1758
D + + L E Y+FRV A N +G + SEP+
Sbjct: 559 CNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPV 602
Score = 60.9 bits (141), Expect = 5e-08
Identities = 55/239 (23%), Positives = 96/239 (40%), Gaps = 33/239 (13%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEH 1925
P+ P + E+ + + W +P +GGSPI Y I+ V SW++
Sbjct: 510 PAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARF 569
Query: 1926 CIENIKEKDEIIFRISAENTVGVSLPTE----------SQSVRLEKHAT----------- 1964
+ + E IFR+ A N +G+ P+ ++ RL+ +
Sbjct: 570 PVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTE 629
Query: 1965 -------VPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVG 2017
VP PPT L + + V+ SW P G ++ Y + + W V
Sbjct: 630 EEPSEGIVPGPPT-DLSVTEATRSYVVLSWKPPGQRGHEGIM-YFVEKCEAGTENWQRVN 687
Query: 2018 -KVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGE 2075
++ V + +F + DL+E +Y R+ N G+ EP E+ E + G+ + PG+
Sbjct: 688 TELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATE--VTVVGDKLDIPKAPGK 744
Score = 55.6 bits (128), Expect = 2e-06
Identities = 49/197 (24%), Positives = 81/197 (41%), Gaps = 12/197 (6%)
Query: 1284 VEFPPKI-VDYEREYR-IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSK 1341
+ F K V + RE + G V + + + F QP +W N + K + +
Sbjct: 405 IHFDDKFDVSFGREGETMSLGCRVVITPEIKHF-QPEIQWYRNGVPLSPSKWVQTLWSGE 463
Query: 1342 SASLTIKKVENTDAGIYKLRL------ENNCGHADV-EMNVTILDKPSPPGKPNILEIDS 1394
A+LT + D G+Y +R+ E + V + + I P+ P LE +
Sbjct: 464 RATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVKCLEANK 523
Query: 1395 SSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFR 1452
I I W +P G S I+ Y ++ E+ T W + + + + L SY FR
Sbjct: 524 DYIIISWKQPAVDGGSPILGYFIDKCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFR 583
Query: 1453 AYAVNEVDISDASETTE 1469
AVN++ I S +E
Sbjct: 584 VRAVNKMGIGFPSRVSE 600
Score = 51.6 bits (118), Expect = 3e-05
Identities = 37/114 (32%), Positives = 55/114 (48%), Gaps = 6/114 (5%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQE-IDTT--EW--ISVKNITK 1435
PSPP LE S+ + W +P+ TG + I Y V Y+E ID +W +VK +++
Sbjct: 934 PSPPCDITCLESFRDSMVLGWKQPDKTGGAEITGYYVNYREVIDGVPGKWREANVKAVSE 993
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLK 1489
I N K N Y+F+ A+N + S +E +K +E I P LK
Sbjct: 994 EAYKISNSKENMVYQFQVAAMNMAGLGAPSAVSECFK-CEEWTIAVPGPPHSLK 1046
Score = 51.2 bits (117), Expect = 4e-05
Identities = 47/233 (20%), Positives = 86/233 (36%), Gaps = 14/233 (6%)
Query: 488 LNEKIDKLPVFEKPTSEEQSM-APIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQ 546
L + +++ + +E+ + AP F+ K R + V+ C + G+P P++TW++
Sbjct: 254 LRKTLEETETYHAKLNEDHLLHAPEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKN 313
Query: 547 TAIIKPSQDFQMYYDDD--NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPL 604
I + Y + + TL I ED + A N G S+ ++V+
Sbjct: 314 QVPINVHANPGKYIIESRYGMHTLEINACDFEDTAQYRASAMNVKGELSAYASVVVKRYK 373
Query: 605 SDHGSEMTVXXXXXXXXXXXXA--DILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPE 662
+ F K + EG + L CR+V PE
Sbjct: 374 GEFDETRFHAGASTMPLSFGVTPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPE 433
Query: 663 -----PDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTV 710
P+I W G + P + + + + L +++ K EG YT+
Sbjct: 434 IKHFQPEIQWYRNGVPLSPSKWVQTLWSGER----ATLTFSHLNKEDEGLYTI 482
Score = 49.2 bits (112), Expect = 2e-04
Identities = 81/384 (21%), Positives = 150/384 (39%), Gaps = 30/384 (7%)
Query: 457 YVQKHLTEEKGWVPAQYLMD---ENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFV 513
+++K E++G Q L D N+ T L + +K+ K F++ + P FV
Sbjct: 1304 FMEKLQDEDEGTYTFQ-LQDGKATNHSTVVLVGDVFKKLQKEAEFQRQ-EWIRKQGPHFV 1361
Query: 514 EKLRPKHTPDGSTVQFECQVEGYPRP-QITWFRQTAIIKPSQDFQMYYDDDNVATLVIRE 572
E L + T + V +C+V + I W++ I + D + TL+I E
Sbjct: 1362 EYLSWEVTGE-CNVLLKCKVANIKKETHIVWYKDEREISVDEKHDF---KDGICTLLITE 1417
Query: 573 VFPEDAGTFTCVAKNAAGFASSTTELIVEA---PLSDHGSEMTVXXXXXXXXXXXXADIL 629
+DAG + + K+ G S +L+ EA + + ++ + L
Sbjct: 1418 FSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELMMEVCKKIALSATDLKIQSTAEGIQL 1477
Query: 630 EGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMH 689
+ + K + GS I R+ + WL E P N D
Sbjct: 1478 YSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGEQIWLQINE---PTPN-------DKG 1527
Query: 690 MYCSVLKITNVKKFQEGTYTVVA-VNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VR 747
Y V+++ + K + T + E A + + EK +V+ L ++ ++
Sbjct: 1528 KY--VMELFDGKTGHQKTVDLSGQAYDEAYAEFQRLKQAAIAEKNRARVLGGLPDVVTIQ 1585
Query: 748 QGESVILSAQVVGNPRPTITWCKNNKPVKA---LPTKSDGDTHSITILKPKKVKDEGVYT 804
+G+++ L+ V G+P P ++W KN K + + K + + + D G Y
Sbjct: 1586 EGKALNLTCNVWGDPPPEVSWLKNEKALASDGHCNLKFEAGRTAYFTINGVSTADSGKYG 1645
Query: 805 LKAENSEGIAETSAVITVEEPTEE 828
L +N G + ++V P EE
Sbjct: 1646 LVVKNKYGSETSDFTVSVFIPEEE 1669
Score = 44.8 bits (101), Expect = 0.003
Identities = 55/207 (26%), Positives = 85/207 (41%), Gaps = 39/207 (18%)
Query: 734 PPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVK--ALPTK----SDGDTH 787
P +I+P +S V + E+V L + G P P +TW KN P+ A P K S H
Sbjct: 277 PEFIIKP-RSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH 335
Query: 788 SITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEE-----------------PTEENA 830
++ I +D Y A N +G A + V+ P
Sbjct: 336 TLEI-NACDFEDTAQYRASAMNVKGELSAYASVVVKRYKGEFDETRFHAGASTMPLSFGV 394
Query: 831 EPPLFINRFQ-------EITVKEKG-TIKLVARVTRNPV-----PSITWYRNNEIISPSE 877
P + +RF+ +++ +G T+ L RV P P I WYRN +SPS+
Sbjct: 395 TPYGYASRFEIHFDDKFDVSFGREGETMSLGCRVVITPEIKHFQPEIQWYRNGVPLSPSK 454
Query: 878 TITQNFDGENIELVITNVDSEIDSGDY 904
+ + GE L ++++ E D G Y
Sbjct: 455 WVQTLWSGERATLTFSHLNKE-DEGLY 480
Score = 44.4 bits (100), Expect = 0.005
Identities = 32/142 (22%), Positives = 60/142 (42%), Gaps = 10/142 (7%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WISVKN--ITKT 1436
P PP E+ S+ + W P ++G + + Y V+ +E E W + I
Sbjct: 1039 PGPPHSLKCSEVRKDSLVLQWKPPVHSGRTPVTGYFVDLKEAKAKEDQWRGLNEAAIKNV 1098
Query: 1437 QTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN 1496
++ LK SY FR A+N+ + S+ V+ ET+ P ++ + N+ +
Sbjct: 1099 YLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAG--PVVAETR---PGTKEVVVNVDDDGV 1153
Query: 1497 EDIELTCIFGGVPQPKVTWYRD 1518
+ C P+ + +W +D
Sbjct: 1154 ISLNFEC-DKMTPKSEFSWSKD 1174
Score = 44.0 bits (99), Expect = 0.006
Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 5/117 (4%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKN---ITKTQ 1437
P PP ++ E S + + W P G+ I+Y+ VE E T W V + +
Sbjct: 638 PGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYF-VEKCEAGTENWQRVNTELPVKSPR 696
Query: 1438 TSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKI-QSPTVEKPLKNITT 1493
++ +L SY FR N + + SE TE V + I ++P P +N T
Sbjct: 697 FALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDT 753
Score = 43.2 bits (97), Expect = 0.010
Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 20/213 (9%)
Query: 996 VIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINS--ETADVVWERDG 1053
V K + K+ E +++ P F+ L +EV + +L+ ++ + + +VW +D
Sbjct: 1337 VFKKLQKEAEFQRQEWIRKQGPHFVEYLS-WEVTGECNVLLKCKVANIKKETHIVWYKDE 1395
Query: 1054 EIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDE--SCTAEVTVV-----ELP 1106
I + K+DF K G I L I S D G Y IL+D+ + + +V EL
Sbjct: 1396 REISVDE-KHDF-KDG-ICTLLITEFSKKDAGIYEVILKDDRGKDKSRLKLVDEAFKELM 1452
Query: 1107 PEII-------TRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGK 1159
E+ T L+ Q +G + + D V W +GS I++S+ ++ + G+
Sbjct: 1453 MEVCKKIALSATDLKIQSTAEGIQLYSFVTYYVEDLKVNWSHNGSAIRYSDRVKTGVTGE 1512
Query: 1160 KQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVE 1192
+ L+I + +D G+Y E+ + K TV+
Sbjct: 1513 QIWLQINEPTPNDKGKYVMELFDGKTGHQKTVD 1545
Score = 43.2 bits (97), Expect = 0.010
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 1592 VTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKE-KTSVIRIKELKRSHSSKYTIEASNT 1650
+T + G PPPEV W KN L +D N+ + +T+ I + + S KY + N
Sbjct: 1592 LTCNVWGDPPPEVSWLKNEKALASDGHCNLKFEAGRTAYFTINGVSTADSGKYGLVVKNK 1651
Query: 1651 AGTSSVEVTLKVY 1663
G+ + + T+ V+
Sbjct: 1652 YGSETSDFTVSVF 1664
Score = 41.5 bits (93), Expect = 0.032
Identities = 31/124 (25%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 1358 YKLRLENNCGHADVE--MNVTI----LDKPSPPGKPNILEIDSSSINICWDEPENTGNST 1411
+++R N+ G + VT+ LD P PGK +S+ + W+E ++
Sbjct: 710 FRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDA--KE 767
Query: 1412 IIYYVVEYQEIDTTEWISVKN--ITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
++ Y +E + +W N + ++ + L T SY FR AVN +S+ S+ +E
Sbjct: 768 LVGYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVRAVNAAGLSEYSQDSE 827
Query: 1470 YYKV 1473
+V
Sbjct: 828 AIEV 831
Score = 40.3 bits (90), Expect = 0.074
Identities = 33/102 (32%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 833 PLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRN----NEIISPSETITQNFDGENI 888
P FI + + TV EK +KL + P P +TWY+N N +P + I ++ G +
Sbjct: 277 PEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH- 335
Query: 889 ELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTF 930
L I D E D+ Y+ A N G+ S A V + K F
Sbjct: 336 TLEINACDFE-DTAQYRASAMNVKGELSAYASVVVKRYKGEF 376
Score = 39.5 bits (88), Expect = 0.13
Identities = 19/82 (23%), Positives = 34/82 (41%)
Query: 842 ITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDS 901
+T++E + L V +P P ++W +N + ++ F+ N S DS
Sbjct: 1582 VTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDGHCNLKFEAGRTAYFTINGVSTADS 1641
Query: 902 GDYKCVASNSAGKSSHGARVTI 923
G Y V N G + V++
Sbjct: 1642 GKYGLVVKNKYGSETSDFTVSV 1663
Score = 39.1 bits (87), Expect = 0.17
Identities = 64/280 (22%), Positives = 115/280 (41%), Gaps = 40/280 (14%)
Query: 1126 FEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSK- 1184
FE + + W KD + S +++ G K K+ D +DD G YSC+V ++
Sbjct: 1158 FECDKMTPKSEFSWSKDYVSTEDSPRLEVESKGNKTKMTFKDLGMDDLGIYSCDVTDTDG 1217
Query: 1185 CTAILTVEEPSINFTLRLP---EFILVPANTDAYLTVEIPDETLDVTW------------ 1229
+ ++E + L L +F VP ++ L VEI ++ W
Sbjct: 1218 IASSYLIDEEELKRLLALSHEHKFPTVPVKSE--LAVEILEKGQVRFWMQAEKLSGNAKV 1275
Query: 1230 ---YKKKSVIEDTE-KFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAK----STTKLKV 1281
+ +K + E + K + + + + K ++D+ YT L D K ST L
Sbjct: 1276 NYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQLQDGKATNHSTVVLVG 1335
Query: 1282 EVVEFPPKIVDYER-EYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKH------- 1333
+V + K +++R E+ K+G + ++ + N IKK H
Sbjct: 1336 DVFKKLQKEAEFQRQEWIRKQGPHFVEYLSWEVTGECNVLLKCKVANIKKETHIVWYKDE 1395
Query: 1334 TKPSIDSKS------ASLTIKKVENTDAGIYKLRLENNCG 1367
+ S+D K +L I + DAGIY++ L+++ G
Sbjct: 1396 REISVDEKHDFKDGICTLLITEFSKKDAGIYEVILKDDRG 1435
Score = 38.3 bits (85), Expect = 0.30
Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 9/90 (10%)
Query: 747 RQGESVILSAQVVGNP-----RPTITWCKNNKPV---KALPTKSDGDTHSITILKPKKVK 798
R+GE++ L +VV P +P I W +N P+ K + T G+ ++T K +
Sbjct: 417 REGETMSLGCRVVITPEIKHFQPEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNK-E 475
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEE 828
DEG+YT++ E + SA + V + E
Sbjct: 476 DEGLYTIRVRMGEYYEQYSAYVFVRDADAE 505
Score = 38.3 bits (85), Expect = 0.30
Identities = 20/89 (22%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 523 DGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFT 582
+G + C V G P P+++W + + + ++ A I V D+G +
Sbjct: 1586 EGKALNLTCNVWGDPPPEVSWLKNEKALASDGHCNLKFEAGRTAYFTINGVSTADSGKYG 1645
Query: 583 CVAKNAAGFASSTTELIVEAPLSDHGSEM 611
V KN G S T++ V + + + M
Sbjct: 1646 LVVKNKYG--SETSDFTVSVFIPEEEARM 1672
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/93 (26%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 1433 ITKTQTSIQNLKTNSSYRFRAYAVNE----VDISDASETTEYY--KVIKETKIQSPT-VE 1485
++K TS + S + R + E + + E TE Y K+ ++ + +P +
Sbjct: 222 VSKQATSALQQEETSEKKSRKVVIREKAERLSLRKTLEETETYHAKLNEDHLLHAPEFII 281
Query: 1486 KPLKNITTEPNEDIELTCIFGGVPQPKVTWYRD 1518
KP + E E+++L C G P+P+VTWY++
Sbjct: 282 KPRSHTVWE-KENVKLHCSIAGWPEPRVTWYKN 313
Score = 37.9 bits (84), Expect = 0.39
Identities = 24/104 (23%), Positives = 43/104 (41%), Gaps = 4/104 (3%)
Query: 640 PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITN 699
P + EG + L C + P P+++WL + + D + ++ E+ Y I
Sbjct: 1579 PDVVTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDGHCNLKFEAGRTAY---FTING 1635
Query: 700 VKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQ-VIEPLK 742
V G Y +V N+ G + + + E+E +E LK
Sbjct: 1636 VSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEEARMAALESLK 1679
Score = 35.9 bits (79), Expect = 1.6
Identities = 20/80 (25%), Positives = 35/80 (43%), Gaps = 1/80 (1%)
Query: 1299 IKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDS-KSASLTIKKVENTDAGI 1357
I+ G + L + P P W+ N K + H ++ ++A TI V D+G
Sbjct: 1584 IQEGKALNLTCNVWGDPPPEVSWLKNEKALASDGHCNLKFEAGRTAYFTINGVSTADSGK 1643
Query: 1358 YKLRLENNCGHADVEMNVTI 1377
Y L ++N G + V++
Sbjct: 1644 YGLVVKNKYGSETSDFTVSV 1663
Score = 34.3 bits (75), Expect = 4.9
Identities = 32/102 (31%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENI-SVAIESDMHMYC 692
P F KP++ V E ++ L C + PEP + W I N IES M+
Sbjct: 277 PEFIIKPRSHTVWEKENVKLHCSIAGWPEPRVTWYKNQVPINVHANPGKYIIESRYGMH- 335
Query: 693 SVLKITNVKKFQE-GTYTVVAVNREGEAS--LPIVLKIKTGE 731
L+I N F++ Y A+N +GE S +V+K GE
Sbjct: 336 -TLEI-NACDFEDTAQYRASAMNVKGELSAYASVVVKRYKGE 375
>AK074780-1|BAC11205.1| 570|Homo sapiens protein ( Homo sapiens
cDNA FLJ90299 fis, clone NT2RP2000514, highly similar to
Homo sapiens roundabout 2 (robo2) mRNA. ).
Length = 570
Score = 83.4 bits (197), Expect = 8e-15
Identities = 65/241 (26%), Positives = 102/241 (42%), Gaps = 13/241 (5%)
Query: 705 EGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRP 764
EGTY +A NR G+ L ++ PPQ + + IV QG +V + GNP+P
Sbjct: 5 EGTYMCIAENRVGKMEASATLTVRARPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQP 64
Query: 765 TITWCKN--------NKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAET 816
+ W K N+P + S T +TI ++ D G Y +A G
Sbjct: 65 AVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQR-SDAGYYICQALTVAGSILA 123
Query: 817 SAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPS 876
A + V + + PP+ + T+ GT L + T +P+P I+W + P
Sbjct: 124 KAQLEVTDVLTDR-PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG-FTFPG 181
Query: 877 ETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQK 936
E L I N+ D+G Y CVA++S+G++S A + + T K+
Sbjct: 182 RDPRATIQ-EQGTLQIKNLRIS-DTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDL 239
Query: 937 S 937
S
Sbjct: 240 S 240
Score = 66.9 bits (156), Expect = 7e-10
Identities = 45/195 (23%), Positives = 80/195 (41%), Gaps = 3/195 (1%)
Query: 633 PPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY- 691
PP F +P+ Q V +G + C P+P + W +G + + N S +
Sbjct: 34 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 93
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIK--TGEKEPPQVIEPLKSMIVRQG 749
L ITN+++ G Y A+ G L++ ++ PP +++ + +
Sbjct: 94 TGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 153
Query: 750 ESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAEN 809
+ +L + G+P P I+W K ++ +K ++ D G YT A +
Sbjct: 154 GTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATS 213
Query: 810 SEGIAETSAVITVEE 824
S G SAV+ V E
Sbjct: 214 SSGETSWSAVLDVTE 228
Score = 60.1 bits (139), Expect = 9e-08
Identities = 77/337 (22%), Positives = 128/337 (37%), Gaps = 39/337 (11%)
Query: 1451 FRAYAVNEVDISDASETTEYYKVIKETKIQSPT-VEKPLKNITTEPNEDIELTCIFGGVP 1509
+ A N V +AS T ++ + P V +P I + + C G P
Sbjct: 8 YMCIAENRVGKMEASATL----TVRARPVAPPQFVVRPRDQIVAQ-GRTVTFPCETKGNP 62
Query: 1510 QPKVTWYRDGKK---------LKTAKATYENRXXXXXXXXXXXXXXXYKCIAFNDHGEVE 1560
QP V W ++G + ++ + Y C A G +
Sbjct: 63 QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSIL 122
Query: 1561 TSCVVGIQQ----KPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLEND 1616
+ + +P I Q V L+ G P P + W K G
Sbjct: 123 AKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPG- 181
Query: 1617 KEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVY------------- 1663
++ T +E+ ++IK L+ S + YT A++++G +S L V
Sbjct: 182 RDPRATIQEQ-GTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLS 240
Query: 1664 DKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPD-NNRWIKVADVDRD 1722
D P P P + ++++ SVT+ W+P G L + Y IE +N W VA+ +
Sbjct: 241 DLPGPPSKPQVT-DVTKNSVTLSWQPGTP-GTLPASAYIIEAFSQSVSNSWQTVANHVKT 298
Query: 1723 VETYCIQKLNENCEYMFRVIAQNPVGFSE-ALESEPI 1758
Y ++ L N Y+F V A NP G S+ + S+P+
Sbjct: 299 T-LYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPV 334
Score = 58.4 bits (135), Expect = 3e-07
Identities = 58/222 (26%), Positives = 88/222 (39%), Gaps = 34/222 (15%)
Query: 510 PIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTA--IIKPSQDFQ--MYYDDDNV 565
P FV + R + G TV F C+ +G P+P + W ++ + ++ P+Q Q
Sbjct: 35 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 94
Query: 566 ATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXXXX 625
L I + DAG + C A AG + +L V L+D
Sbjct: 95 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP----------------- 137
Query: 626 ADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIE 685
PP + P Q + LL+C+ P P I+WL +G P + I+
Sbjct: 138 -------PPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF-PGRDPRATIQ 189
Query: 686 SDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKI 727
L+I N++ GTYT VA + GE S VL +
Sbjct: 190 EQ-----GTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 226
Score = 57.6 bits (133), Expect = 5e-07
Identities = 28/103 (27%), Positives = 52/103 (50%), Gaps = 3/103 (2%)
Query: 1369 ADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVE-YQEIDTTEW 1427
A + N + D P PP KP + ++ +S+ + W +P G Y++E + + + W
Sbjct: 231 ATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW-QPGTPGTLPASAYIIEAFSQSVSNSW 289
Query: 1428 ISVKNITKTQT-SIQNLKTNSSYRFRAYAVNEVDISDASETTE 1469
+V N KT +++ L+ N+ Y F A+N +SD S ++
Sbjct: 290 QTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSD 332
Score = 48.4 bits (110), Expect = 3e-04
Identities = 36/120 (30%), Positives = 53/120 (44%), Gaps = 9/120 (7%)
Query: 799 DEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTR 858
DEG Y AEN G E SA +TV PP F+ R ++ V + T+
Sbjct: 4 DEGTYMCIAENRVGKMEASATLTVR---ARPVAPPQFVVRPRDQIVAQGRTVTFPCETKG 60
Query: 859 NPVPSITWYR--NNEIISPSETITQNFD---GENIELVITNVDSEIDSGDYKCVASNSAG 913
NP P++ W + + ++ P++ N +L ITN+ D+G Y C A AG
Sbjct: 61 NPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS-DAGYYICQALTVAG 119
Score = 43.2 bits (97), Expect = 0.010
Identities = 61/218 (27%), Positives = 88/218 (40%), Gaps = 26/218 (11%)
Query: 1083 DEGEYSCILRDE----SCTAEVTVVE---LPPEIITRLQNQKVNKGNKATFEIELTKGD- 1134
DEG Y CI + +A +TV PP+ + R ++Q V +G TF E TKG+
Sbjct: 4 DEGTYMCIAENRVGKMEASATLTVRARPVAPPQFVVRPRDQIVAQGRTVTFPCE-TKGNP 62
Query: 1135 -ALVRWFKDGSE-IQFSNHIQLTID----GKKQKLKIYDCDLDDAGEYSCEVGNSKCTAI 1188
V W K+GS+ + F N Q L I + DAG Y C+ + +
Sbjct: 63 QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSIL 122
Query: 1189 LTVE-EPSINFTLRLPEFILV-PANT------DAYLTVEIPDETLDV-TWYKKKSVIEDT 1239
+ E + T R P IL PAN A L + + L V +W K+
Sbjct: 123 AKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGR 182
Query: 1240 EKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSTT 1277
+ I + + TL I+ D YTCV + T
Sbjct: 183 DPRATIQE--QGTLQIKNLRISDTGTYTCVATSSSGET 218
Score = 41.1 bits (92), Expect = 0.042
Identities = 38/118 (32%), Positives = 56/118 (47%), Gaps = 15/118 (12%)
Query: 1865 PPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIE-FKTVKGKSWTKIVTVGGSVH 1923
PPS+P+ V++ T SVTL W +P + G P + YIIE F SW TV V
Sbjct: 245 PPSKPQ---VTDVTKNSVTLSW-QPGTPGTLPASAYIIEAFSQSVSNSWQ---TVANHVK 297
Query: 1924 E--HCIENIKEKDEIIFRISAENTVGVSLPTE-SQSVRLEKHATVPSPPTAPLEIRMV 1978
+ + ++ +F + A N G+S P+ S VR + SPP ++ R V
Sbjct: 298 TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQD----ISPPAQGVDHRQV 351
Score = 33.9 bits (74), Expect = 6.4
Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 14/143 (9%)
Query: 1271 LDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIV--NSKII 1328
++A +T ++ V PP+ V R+ + +G VT + + PQP W + ++
Sbjct: 19 MEASATLTVRARPVA-PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLL 77
Query: 1329 KKCKHTKPSID---SKSASLTIKKVENTDAGIYKLRLENNCG----HADVEMNVTILDKP 1381
+ +P+ S + LTI ++ +DAG Y + G A +E+ + D+P
Sbjct: 78 FPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP 137
Query: 1382 SP---PGKPN-ILEIDSSSINIC 1400
P G N L +D +++ C
Sbjct: 138 PPIILQGPANQTLAVDGTALLKC 160
>U55258-1|AAC50765.1| 1299|Homo sapiens hBRAVO/Nr-CAM precursor
protein.
Length = 1299
Score = 82.6 bits (195), Expect = 1e-14
Identities = 117/532 (21%), Positives = 209/532 (39%), Gaps = 59/532 (11%)
Query: 1489 KNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXXX---XX 1545
+N+ P ED L C G P+P+++W +G ++ A +
Sbjct: 363 QNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSS 422
Query: 1546 XXYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVI 1605
Y+C A N++G + + V + +P ++ + + L+ G P P +
Sbjct: 423 AVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIE 482
Query: 1606 WYKN--GNKLEND-----KEYNITTKEKTSVIR-IKELKRSHSSKYTIEASNTAGTSSVE 1657
W+K G+ L D + + K+ T +++ I ++ + YT A N G + E
Sbjct: 483 WFKGAKGSALHEDIYVLHENGTLEIKDATWIVKEIPVAQKDSTGTYTCVARNKLGMAKNE 542
Query: 1658 VTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHE--PDNNRWIK 1715
V L+ PE V+ R V+ E K D L LT ++ + P + R+
Sbjct: 543 VHLQ-------PEYAVVQRG---SMVSFECKVK-HDHTLSLTVLWLKDNRELPSDERFT- 590
Query: 1716 VADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKT-----ALDVPSXX 1770
VD+D + ++++ + +A + A +V T DVP+
Sbjct: 591 ---VDKD--HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPP 645
Query: 1771 XXXXXXXXIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKK---WKXXXXXXXXXARIQ 1827
+D +SV ++W P + N SPI + +E + K W Q
Sbjct: 646 FDLELTDQLD-KSVQLSWTPGDDNN-SPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQ 703
Query: 1828 -KLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKW 1886
KLS Y FR+ A N IG SLP + ++ + K P P S ++ + W
Sbjct: 704 LKLSPYVNYSFRVMAVNSIGKSLPSEASEQY-LTKASEPDKNPTAVEGLGSEPDNLEITW 762
Query: 1887 TEP----ESNGGSPITNYIIEFKTVKG-KSWTKIVTVGGSVHEHCIENIKEKDEIIFRIS 1941
+P ESNG P Y + ++ G WT +V +V ++ + + ++
Sbjct: 763 -KPLNGFESNG--PGLQYKVSWRQKDGDDEWTSVVV--ANVSKYIVSGTPTFVPYLIKVQ 817
Query: 1942 AENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWD 1993
A N +G + + + H+ P AP +R+ N+V ++ WD
Sbjct: 818 ALNDMGFA----PEPAVVMGHSGEDLPMVAPGNVRV---NVVNSTLAEVHWD 862
Score = 79.0 bits (186), Expect = 2e-13
Identities = 117/486 (24%), Positives = 190/486 (39%), Gaps = 64/486 (13%)
Query: 507 SMAPIFV-EKLRPKHTPDGSTVQFECQVE-GYPRPQITWFRQTAIIKP-SQDFQMYYDDD 563
S +P++ EKL P G ++ C+ G P P I W + P S+ + D
Sbjct: 137 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGD 196
Query: 564 NVATLVIREVFPEDAGT-FTCVAK-NAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXX 621
L V PED + C A+ N + V+ D ++ T+
Sbjct: 197 ----LYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELND-TIAANLSDTE 251
Query: 622 XXXXADILEGIPPTF-SKKPKAQYVDE--GSDILLECRLVAIPEPDIAWLFKGEEIVPDE 678
E PPTF + + A +E G+ + LEC +P P I W K + ++P +
Sbjct: 252 FYGAKSSRER-PPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWA-KEDGMLP-K 308
Query: 679 NISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVI 738
N +V + L+I +V + G Y +A N G I +++K P I
Sbjct: 309 NRTVYKNFE-----KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAA----PYWI 359
Query: 739 EPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALP----TKSDGDTHSITILKP 794
+++++ GE L + GNP+P I+W N P++ P K DGDT I
Sbjct: 360 TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDT---IIFSN 416
Query: 795 KKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEI-TVKEKGTIKLV 853
+ + VY A N G +A + V AEPP + + V L
Sbjct: 417 VQERSSAVYQCNASNEYGYLLANAFVNV------LAEPPRILTPANTLYQVIANRPALLD 470
Query: 854 ARVTRNPVPSITWYRNNEIISPSETITQNFDGENIELV-ITNVDSEI------DSGDYKC 906
+P+P+I W++ + + E I + +E+ T + EI +G Y C
Sbjct: 471 CAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIKDATWIVKEIPVAQKDSTGTYTC 530
Query: 907 VASNSAGKSSHGARVTIDVEKVTFVKHLQKSYE-TEEGKTVILECQTSH----TVSTKWY 961
VA N G + + HLQ Y + G V EC+ H +++ W
Sbjct: 531 VARNKLGMAKNEV-------------HLQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWL 577
Query: 962 HNKKEI 967
+ +E+
Sbjct: 578 KDNREL 583
Score = 71.7 bits (168), Expect = 3e-11
Identities = 74/323 (22%), Positives = 143/323 (44%), Gaps = 42/323 (13%)
Query: 633 PPTFSKK-PKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMY 691
PPT +++ PK +D +I+++C P P +W G D++ V ++
Sbjct: 40 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 99
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEA-SLPIVLKIKTGEKEPPQVIEPLKSMIVRQGE 750
+ + EG Y A N G A S IV++ + P E L+ + ++ G+
Sbjct: 100 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVR---PSRSPLWTKEKLEPITLQSGQ 156
Query: 751 SVILSAQ-VVGNPRPTITWCKNNKPVKALPTKS------DGDTHSITILKPKKVKDEGVY 803
S++L + +G P P I W N+ + LP +GD + +L P+ +++ +
Sbjct: 157 SLVLPCRPPIGLPPPIIFWMDNS--FQRLPQSERVSQGLNGDLYFSNVL-PEDTREDYIC 213
Query: 804 TLKAENSEGIAE----TSAVITVEE----------PTE------ENAEPPLFINRFQEIT 843
+ +++ I + + VI+V+E TE PP F+ +
Sbjct: 214 YARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNAS 273
Query: 844 VKE--KGTIKLVARVTRN-PVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEID 900
KE +G + + + P P I W + + ++ + T+ +NF+ + ++++ SE D
Sbjct: 274 NKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-KTLQIIHV---SEAD 329
Query: 901 SGDYKCVASNSAGKSSHGARVTI 923
SG+Y+C+A N+ G H V +
Sbjct: 330 SGNYQCIAKNALGAIHHTISVRV 352
Score = 71.3 bits (167), Expect = 3e-11
Identities = 171/776 (22%), Positives = 293/776 (37%), Gaps = 90/776 (11%)
Query: 1044 TADVVWERDGEIIKPKKNKY-DFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTV 1102
T + W ++ ++ + Y +FEK L I + S D G Y CI ++ T+
Sbjct: 294 TPIIYWAKEDGMLPKNRTVYKNFEKT-----LQIIHVSEADSGNYQCIAKNALGAIHHTI 348
Query: 1103 ---VELPPEIITRLQNQKVNKGNKATFEIELTKGDALVR--WFKDGSEIQFS-NHIQLTI 1156
V+ P IT QN ++ G T I G+ R W +G I+ + + I
Sbjct: 349 SVRVKAAPYWITAPQNLVLSPGEDGTL-ICRANGNPKPRISWLTNGVPIEIAPDDPSRKI 407
Query: 1157 DGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYL 1216
DG + + + Y C N + +N L P IL PANT Y
Sbjct: 408 DG--DTIIFSNVQERSSAVYQCNASNEYGYLLANA---FVN-VLAEPPRILTPANT-LYQ 460
Query: 1217 TVEIPDETLD----------VTWYK--KKSVIEDT-----EKFTLISDVKKRTLIIRK-- 1257
+ LD + W+K K S + + E TL ++K T I+++
Sbjct: 461 VIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTL--EIKDATWIVKEIP 518
Query: 1258 -CTEDDQCEYTCVLLD----AKSTTKLKVE-VVEFPPKIVDYEREYRIKRGSDVTLLVDY 1311
+D YTCV + AK+ L+ E V +V +E + + +T+L
Sbjct: 519 VAQKDSTGTYTCVARNKLGMAKNEVHLQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLK 578
Query: 1312 QAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADV 1371
P+DE K H + S S T V NT + A
Sbjct: 579 DNRELPSDERFTVDK-----DHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVV-APT 632
Query: 1372 EMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE--WIS 1429
+ D P+PP + + S+ + W P + NS I +++EY++ W
Sbjct: 633 PTPAPVYDVPNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHH 691
Query: 1430 VKNITKTQTSIQ-NLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPL 1488
++ TQT+ Q L +Y FR AVN + S SE +E Y ++PT + L
Sbjct: 692 QTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGL 751
Query: 1489 KN------ITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRXXXXXXXXXX 1542
+ IT +P E G Q KV+W + + N
Sbjct: 752 GSEPDNLEITWKPLNGFESN---GPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPT 808
Query: 1543 XXXXXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPP 1601
K A ND G E + V+G + + ++ +++ V + L + +P
Sbjct: 809 FVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRV--NVVNSTLAEVHWDPVPL 866
Query: 1602 PEVIWYKNGNKLENDKEYNITTKEKTSV---IRIKELKRSHS--------SKYTIEASNT 1650
+ + G ++ K + + + + + I + ++H S YT+
Sbjct: 867 KSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVV 926
Query: 1651 AGTSSVEVTL-KVYDKP-SKPEGPVIMREI--SRESVTIEWKPPLDDGGLELTKYAIEKH 1706
G + +V++ P P P ++ + + +S+T+EW PP G+ LT+Y + K+
Sbjct: 927 NGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGI-LTEYTL-KY 984
Query: 1707 EPDNNRWIKVADVDRDVET----YCIQKLNENCEYMFRVIAQNPVGFSEALESEPI 1758
+P N+ VD + + ++ LN + Y F AQ G + E +
Sbjct: 985 QPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAV 1040
Score = 63.7 bits (148), Expect = 7e-09
Identities = 79/303 (26%), Positives = 122/303 (40%), Gaps = 43/303 (14%)
Query: 634 PTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGE--EIVPDENISVAIESDMHMY 691
P + P+ + G D L CR P+P I+WL G EI PD+ S I+ D ++
Sbjct: 356 PYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDP-SRKIDGDTIIF 414
Query: 692 CSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMI-VRQGE 750
+NV++ Y A N G + + EPP+++ P ++ V
Sbjct: 415 ------SNVQERSSAVYQCNASNEYGYLLANAFVNVLA---EPPRILTPANTLYQVIANR 465
Query: 751 SVILSAQVVGNPRPTITWCKNNK------PVKALPTKSDGDTHSIT-ILK--PKKVKDE- 800
+L G+P PTI W K K + L + T I+K P KD
Sbjct: 466 PALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIKDATWIVKEIPVAQKDST 525
Query: 801 GVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNP 860
G YT A N G+A+ + E + F E VK T+ L
Sbjct: 526 GTYTCVARNKLGMAKNEVHLQPEYAVVQRGSMVSF-----ECKVKHDHTLSL-------- 572
Query: 861 VPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGAR 920
++ W ++N + E T + D LV+ +V S+ DSG Y CVA+ + S A
Sbjct: 573 --TVLWLKDNRELPSDERFTVDKD----HLVVADV-SDDDSGTYTCVANTTLDSVSASAV 625
Query: 921 VTI 923
+++
Sbjct: 626 LSV 628
Score = 62.9 bits (146), Expect = 1e-08
Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 8/191 (4%)
Query: 1866 PSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKS--WTKIVTVGGSVH 1923
P+ P + +++ +SV L WT P + SPIT +IIE++ K W V G+
Sbjct: 642 PNPPFDLELTDQLDKSVQLSWT-PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 700
Query: 1924 EHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIV 1983
++ + FR+ A N++G SLP+E+ L K + PTA + N+
Sbjct: 701 TAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLE 759
Query: 1984 MTSWGTPEWDGGAPLLGYNIAIRDVT-KTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIY 2042
+T ++ P L Y ++ R W V V N K+ + Y+I++
Sbjct: 760 ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSV--VVANVSKYIVSGTPTFVPYLIKVQ 817
Query: 2043 ARNEIGLS-EP 2052
A N++G + EP
Sbjct: 818 ALNDMGFAPEP 828
Score = 57.6 bits (133), Expect = 5e-07
Identities = 63/290 (21%), Positives = 114/290 (39%), Gaps = 12/290 (4%)
Query: 1383 PPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQN 1442
PP P I +D+S + E + G + +Y+ E ++I TQT IQ
Sbjct: 169 PP--PIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQT-IQQ 225
Query: 1443 LKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPN---EDI 1499
+ S +N+ ++ S+T E+Y K ++ + PT P N + + +
Sbjct: 226 KQPISVKVISVDELNDTIAANLSDT-EFYGA-KSSRERPPTFLTPEGNASNKEELRGNVL 283
Query: 1500 ELTCIFGGVPQPKVTWYRDGKKLKTAKATYEN-RXXXXXXXXXXXXXXXYKCIAFNDHGE 1558
L CI G+P P + W ++ L + Y+N Y+CIA N G
Sbjct: 284 SLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGA 343
Query: 1559 VETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKE 1618
+ + V ++ P + +++ G++ + G P P + W NG +E +
Sbjct: 344 IHHTISVRVKAAPYWITAPQNLVL--SPGEDGTLICRANGNPKPRISWLTNGVPIEIAPD 401
Query: 1619 YNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSK 1668
+ + K I ++ S+ Y ASN G + V +P +
Sbjct: 402 -DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPR 450
Score = 44.4 bits (100), Expect = 0.005
Identities = 171/820 (20%), Positives = 305/820 (37%), Gaps = 105/820 (12%)
Query: 721 LPIVLKIKTGEKEPPQVIEPL-KSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKA-- 777
+P+ K+ +PP + + K I+ E++++ + G P P+ +W +N
Sbjct: 27 VPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDK 86
Query: 778 --LPTKSDGD-THSITILKPKKVKD-EGVYTLKAENSEGIAETSAVIT--VEEP--TEEN 829
L T G T I I+ K + EGVY A N G A ++ ++ P T+E
Sbjct: 87 DPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEK 146
Query: 830 AEP---------------------PLFI---NRFQEITVKEKGTIKLVARVT-RNPVPSI 864
EP P+ N FQ + E+ + L + N +P
Sbjct: 147 LEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPED 206
Query: 865 TWYRNNEIISPSETITQNFDGEN-IELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
T R + I TQ + I + + +VD D+ +A+N + +GA+ +
Sbjct: 207 T--REDYICYARFNHTQTIQQKQPISVKVISVDELNDT-----IAANLSDTEFYGAKSSR 259
Query: 924 DVEKVTFVKHLQKSYETEE--GKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRX 981
+ TF+ + EE G + LEC + + T + KE + + +
Sbjct: 260 E-RPPTFLTPEGNASNKEELRGNVLSLEC-IAEGLPTPIIYWAKEDGMLPKNRTVYKNFE 317
Query: 982 XXXXXXXXXXXDVGVIKCIVKDQETS---TMLVVKETIPEFIRKLQDFEVKEKDVAILEV 1038
D G +CI K+ + T+ V + P +I Q+ + + L
Sbjct: 318 KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLIC 377
Query: 1039 EINSETAD-VVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDES-- 1095
N + W +G I+ + D ++ + N Y C +E
Sbjct: 378 RANGNPKPRISWLTNGVPIEIAPD--DPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGY 435
Query: 1096 --CTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKD--GSEIQ-- 1147
A V V+ PP I+T N+ G L + WFK GS +
Sbjct: 436 LLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHED 495
Query: 1148 -FSNHIQLTIDGKKQKLKIYDCDL---DDAGEYSCEVGNSKCTAILTVEEPSINFTLRLP 1203
+ H T++ K + + + D G Y+C N L + + ++ P
Sbjct: 496 IYVLHENGTLEIKDATWIVKEIPVAQKDSTGTYTCVARNK-----LGMAKNEVHLQ---P 547
Query: 1204 EFILVPANTDAYLTVEIP-DETLDVT--WYKKKSVIEDTEKFTLISDVKKRTLIIRKCTE 1260
E+ +V + ++ D TL +T W K + E+FT V K L++ ++
Sbjct: 548 EYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFT----VDKDHLVVADVSD 603
Query: 1261 DDQCEYTCV---LLDAKSTTKLKVEVVEFPPKIVDYE---REYRIKRGSDVTLLVDYQAF 1314
DD YTCV LD+ S + + V P Y+ + ++ + V
Sbjct: 604 DDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWT 663
Query: 1315 PQPNDEWIVNSKIIK-KCKHTKPSI----DSKSASLTIKKVENTDAGIYKLRL--ENNCG 1367
P ++ + II+ + KP + S + T +++ + Y R+ N+ G
Sbjct: 664 PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIG 723
Query: 1368 HA-DVEMNVTILDKPSPPGK-PNILE---IDSSSINICWDEPEN--TGNSTIIYYVVEYQ 1420
+ E + L K S P K P +E + ++ I W +P N N + Y V ++
Sbjct: 724 KSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLEITW-KPLNGFESNGPGLQYKVSWR 782
Query: 1421 EID-TTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEV 1459
+ D EW SV ++ + T Y + A+N++
Sbjct: 783 QKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDM 822
Score = 41.9 bits (94), Expect = 0.024
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 524 GSTVQFECQVEGYPRPQIT--WFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTF 581
GS V FEC+V+ +T W + + + F + D D+ LV+ +V +D+GT+
Sbjct: 555 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTV--DKDH---LVVADVSDDDSGTY 609
Query: 582 TCVAKNAAGFASSTTELIVEAP 603
TCVA S++ L V AP
Sbjct: 610 TCVANTTLDSVSASAVLSVVAP 631
Score = 41.1 bits (92), Expect = 0.042
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 7/109 (6%)
Query: 1381 PSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTE----WISVK-NITK 1435
PS P I+ S+ + WD P + N + Y ++YQ I++T + +K K
Sbjct: 947 PSAPSSLKIVNPTLDSLTLEWDPPSHP-NGILTEYTLKYQPINSTHELGPLVDLKIPANK 1005
Query: 1436 TQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTV 1484
T+ +++NL ++ Y+F YA S + T E + E I P V
Sbjct: 1006 TRWTLKNLNFSTRYKFYFYAQTSAG-SGSQITEEAVTTVDEAGILPPDV 1053
Score = 37.1 bits (82), Expect = 0.69
Identities = 38/146 (26%), Positives = 58/146 (39%), Gaps = 14/146 (9%)
Query: 1476 ETKIQSPTV-EKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDG-------KKLKTAK- 1526
E +Q PT+ ++ K+ +P E+I + C G P P +W R+G L T K
Sbjct: 35 EDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP 94
Query: 1527 ATYENRXXXXXXXXXXXXXXXYKCIAFNDHG-EVETSCVVGIQQKPVITISNEDIKQKHK 1585
T Y+C A N+ G V + VV + P+ T E ++
Sbjct: 95 GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWT--KEKLEPITL 152
Query: 1586 VGDEWLVTAVIE--GIPPPEVIWYKN 1609
+ LV G+PPP + W N
Sbjct: 153 QSGQSLVLPCRPPIGLPPPIIFWMDN 178
Score = 35.5 bits (78), Expect = 2.1
Identities = 50/185 (27%), Positives = 79/185 (42%), Gaps = 30/185 (16%)
Query: 652 LLECRLVAIPEPDIAWLFKG-------EEI-VPDENISVAIESDMHMYCSVLKITNVKKF 703
LL+C P P I W FKG E+I V EN ++ I+ + V +I +K
Sbjct: 468 LLDCAFFGSPLPTIEW-FKGAKGSALHEDIYVLHENGTLEIKDATWI---VKEIPVAQKD 523
Query: 704 QEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPR 763
GTYT VA N+ G A + L+ P+ +V++G V +V +
Sbjct: 524 STGTYTCVARNKLGMAKNEVHLQ--------PEYA------VVQRGSMVSFECKVKHDHT 569
Query: 764 PTIT--WCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVIT 821
++T W K+N+ + + + H ++ D G YT A + SAV++
Sbjct: 570 LSLTVLWLKDNRELPSDERFTVDKDH--LVVADVSDDDSGTYTCVANTTLDSVSASAVLS 627
Query: 822 VEEPT 826
V PT
Sbjct: 628 VVAPT 632
>AK092284-1|BAC03850.1| 885|Homo sapiens protein ( Homo sapiens cDNA
FLJ34965 fis, clone NTONG2004308. ).
Length = 885
Score = 82.6 bits (195), Expect = 1e-14
Identities = 75/292 (25%), Positives = 118/292 (40%), Gaps = 21/292 (7%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
EP ++N PP FI + V E T+ + V PVP + WYRN ++ P E I
Sbjct: 456 EP-KDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMER 514
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI--DVEKVTFV------KHLQ 935
G L I+N+ + G+Y C A N G++ A V I E+V + +H+
Sbjct: 515 VGNVCSLEISNIQKG-EGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVM 573
Query: 936 K-------SYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ S T + ++LE + S K + + +I + +
Sbjct: 574 EFDLEHTTSSRTPSPQEIVLEVELSEK-DVKEFEKQVKIVTVPDFTPDHKSMIVSLDVLP 632
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVE-INSETADV 1047
D + +D+E L V E P FI + DF++ E A+ + I T +V
Sbjct: 633 FNFVDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEV 692
Query: 1048 VWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
W ++ I+P KY + L IRN + D Y C R +C E
Sbjct: 693 KWYKEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRC--RAVNCVGE 742
Score = 59.3 bits (137), Expect = 1e-07
Identities = 107/460 (23%), Positives = 187/460 (40%), Gaps = 73/460 (15%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
++ M P F+E L + + +T+ F +VEG P P + W+R ++++P + +M
Sbjct: 458 KDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKM-ERVG 516
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
NV +L I + + G + C A N G A S + + E V
Sbjct: 517 NVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQ-----EERVVALPPPVTHQH 571
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
LE T S+ P Q +I+LE V + E D+ K +IV + +
Sbjct: 572 VMEFDLE--HTTSSRTPSPQ------EIVLE---VELSEKDVKEFEKQVKIVTVPDFTPD 620
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE-ASLPIVLKIKTGEKEPPQVIEPLK 742
+S M + VL V + +REGE L I L++ + PP+ I P+
Sbjct: 621 HKS-MIVSLDVLPFNFVDPNMD--------SREGEDKELKIDLEV---FEMPPRFIMPIC 668
Query: 743 SMIVRQGESVILSAQVVGNPRPTITW-----CKNNKPVKALPTKSDGDTHSITILKPKKV 797
+ + + V+G P P + W C +K + ++ G +H++ I + +
Sbjct: 669 DFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEKG-SHTLKI-RNVCL 726
Query: 798 KDEGVYTLKAENSEGIA-----------ETSAVI------TVEEPTEENAEPPLFINRFQ 840
D Y +A N G A E AVI T+ EE + + F
Sbjct: 727 SDSATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVLKSNYTDSFF 786
Query: 841 EITVKEKGTIKLVARVT--RNPVPSITWYRNNEIISPSETITQNFDGENIE--------- 889
E V E G + + ++ P+ + +++ SP T+ DG+ ++
Sbjct: 787 EFQVVE-GPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGRRFTVEES 845
Query: 890 ------LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
L IT++ + D G+Y+CVA+N +G + A +T+
Sbjct: 846 GTGFHNLFITSL-VKSDEGEYRCVATNKSGMAESFAALTL 884
Score = 55.6 bits (128), Expect = 2e-06
Identities = 66/340 (19%), Positives = 120/340 (35%), Gaps = 29/340 (8%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
E PP ++ + ++ + + +V+ + P P +W N +++ + K S
Sbjct: 461 EMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCS 520
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK-------PSPPGKPNILEIDSSSI 1397
L I ++ + G Y N G A NV I+ + P P +++E D
Sbjct: 521 LEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEHT 580
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
T + I VE E D E+ VK +T + + S +
Sbjct: 581 T-----SSRTPSPQEIVLEVELSEKDVKEFEKQVKIVTVPDFTPDHKSMIVSLDVLPFNF 635
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY 1516
+ ++ + K+ E P P+ + N D C G+P P+V WY
Sbjct: 636 VDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWY 695
Query: 1517 RDGKKLKTAKATY-----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEV---------ETS 1562
++ ++ Y + Y+C A N GE ++
Sbjct: 696 KEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRCRAVNCVGEAICRGFLTMGDSE 755
Query: 1563 CVVGIQQKPVITISN--EDIKQKHKVGDEWLVTAVIEGIP 1600
I +K +T+S+ E++ K D + V+EG P
Sbjct: 756 IFAVIAKKSKVTLSSLMEELVLKSNYTDSFFEFQVVEGPP 795
Score = 46.0 bits (104), Expect = 0.001
Identities = 67/289 (23%), Positives = 116/289 (40%), Gaps = 29/289 (10%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQ 1161
E+PP I L +KV + F +E+ +G + V+W+++ S ++ I++ G
Sbjct: 461 EMPPSFIEPLTKRKVYENTTLGFIVEV-EGLPVPGVKWYRNKSLLEPDERIKMERVGNVC 519
Query: 1162 KLKIYDCDLDDAGEYSCE----VGNSKCTA---ILTVEE------PSI------NFTLRL 1202
L+I + + GEY C +G +K A I+ EE P + F L
Sbjct: 520 SLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEH 579
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
P+ + L VE+ ++ DV ++K+ I FT D K + + +
Sbjct: 580 TTSSRTPSPQEIVLEVELSEK--DVKEFEKQVKIVTVPDFT--PDHKSMIVSLDVLPFNF 635
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
K+ +EV E PP+ + +++I SD P P +W
Sbjct: 636 VDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWY 695
Query: 1323 VNSKIIK--KCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHA 1369
I+ K+ S + S +L I+ V +D+ Y+ R N G A
Sbjct: 696 KEYMCIEPDNIKYV-ISEEKGSHTLKIRNVCLSDSATYRCRAVNCVGEA 743
Score = 37.9 bits (84), Expect = 0.39
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+EG+P P V WY+N + LE D+ + + I +++ +Y A N G
Sbjct: 487 VEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCSLEISNIQKGEGGEYMCHAVNIIG 543
Score = 37.9 bits (84), Expect = 0.39
Identities = 20/56 (35%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 1598 GIPPPEVIWYKNGNKLENDK-EYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
GIP PEV WYK +E D +Y I+ ++ + ++I+ + S S+ Y A N G
Sbjct: 686 GIPTPEVKWYKEYMCIEPDNIKYVISEEKGSHTLKIRNVCLSDSATYRCRAVNCVG 741
Score = 37.9 bits (84), Expect = 0.39
Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 2/89 (2%)
Query: 1012 VKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGH 1070
V E P FI+ + D A + + S V W +DG++++ ++ + G
Sbjct: 790 VVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGRRFTVEESGTG- 848
Query: 1071 IRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
L+I + DEGEY C+ ++S AE
Sbjct: 849 FHNLFITSLVKSDEGEYRCVATNKSGMAE 877
Score = 35.9 bits (79), Expect = 1.6
Identities = 18/63 (28%), Positives = 27/63 (42%), Gaps = 4/63 (6%)
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAKATYENRXX----XXXXXXXXXXXXXYKCIAFNDHGE 1558
C+ G P+P V WY+DGK ++ + T E Y+C+A N G
Sbjct: 816 CLVRGSPRPTVYWYKDGKLVQGRRFTVEESGTGFHNLFITSLVKSDEGEYRCVATNKSGM 875
Query: 1559 VET 1561
E+
Sbjct: 876 AES 878
>BX537998-1|CAD97954.1| 1263|Homo sapiens hypothetical protein
protein.
Length = 1263
Score = 82.2 bits (194), Expect = 2e-14
Identities = 75/292 (25%), Positives = 118/292 (40%), Gaps = 21/292 (7%)
Query: 824 EPTEENAEPPLFINRFQEITVKEKGTIKLVARVTRNPVPSITWYRNNEIISPSETITQNF 883
EP ++N PP FI + V E T+ + V PVP + WYRN ++ P E I
Sbjct: 834 EP-KDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMER 892
Query: 884 DGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI--DVEKVTFV------KHLQ 935
G L I+N+ + G+Y C A N G++ A V I E+V + +H+
Sbjct: 893 VGNVCSLEISNIQKG-EGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVM 951
Query: 936 K-------SYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRXXXXXXXX 988
+ S T + ++LE + S K + + +I + +
Sbjct: 952 EFDLEHTTSSRTPSPQEIVLEVELSEK-DVKEFEKQVKIVTVPEFTPDHKSMIVSLDVLP 1010
Query: 989 XXXXDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVE-INSETADV 1047
D + +D+E L V E P FI + DF++ E A+ + I T +V
Sbjct: 1011 FNFVDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEV 1070
Query: 1048 VWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
W ++ I+P KY + L IRN + D Y C R +C E
Sbjct: 1071 KWYKEYMCIEPDNIKYVISEEKGSYTLKIRNVCLSDSATYRC--RAVNCVGE 1120
Score = 56.8 bits (131), Expect = 8e-07
Identities = 106/458 (23%), Positives = 183/458 (39%), Gaps = 69/458 (15%)
Query: 504 EEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDD 563
++ M P F+E L + + +T+ F +VEG P P + W+R ++++P + +M
Sbjct: 836 KDNEMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKM-ERVG 894
Query: 564 NVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVXXXXXXXXXX 623
NV +L I + + G + C A N G A S + + E V
Sbjct: 895 NVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQ-----EERVVALPPPVTHQH 949
Query: 624 XXADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVA 683
LE T S+ P Q +I+LE V + E D+ K +IV +
Sbjct: 950 VMEFDLE--HTTSSRTPSPQ------EIVLE---VELSEKDVKEFEKQVKIVTVPEFTPD 998
Query: 684 IESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGE-ASLPIVLKIKTGEKEPPQVIEPLK 742
+S M + VL V + +REGE L I L++ + PP+ I P+
Sbjct: 999 HKS-MIVSLDVLPFNFVDPNMD--------SREGEDKELKIDLEV---FEMPPRFIMPIC 1046
Query: 743 SMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTK--SDGDTHSITI-LKPKKVKD 799
+ + + V+G P P + W K ++ K + S T+ ++ + D
Sbjct: 1047 DFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEKGSYTLKIRNVCLSD 1106
Query: 800 EGVYTLKAENSEGIA-----------ETSAVI------TVEEPTEENAEPPLFINRFQEI 842
Y +A N G A E AVI T+ EE + + F E
Sbjct: 1107 SATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAKKSKVTLSSLMEELVLKSNYTDSFFEF 1166
Query: 843 TVKEKGTIKLVARVT--RNPVPSITWYRNNEIISPSETITQNFDGENIE----------- 889
V E G + + ++ P+ + +++ SP T+ DG+ ++
Sbjct: 1167 QVVE-GPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGRRFTVEESGT 1225
Query: 890 ----LVITNVDSEIDSGDYKCVASNSAGKSSHGARVTI 923
L IT++ + D G+Y+CVA+N +G + A +T+
Sbjct: 1226 GFHNLFITSL-VKSDEGEYRCVATNKSGMAESFAALTL 1262
Score = 56.4 bits (130), Expect = 1e-06
Identities = 66/340 (19%), Positives = 121/340 (35%), Gaps = 29/340 (8%)
Query: 1285 EFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSAS 1344
E PP ++ + ++ + + +V+ + P P +W N +++ + K S
Sbjct: 839 EMPPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCS 898
Query: 1345 LTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDK-------PSPPGKPNILEIDSSSI 1397
L I ++ + G Y N G A NV I+ + P P +++E D
Sbjct: 899 LEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEHT 958
Query: 1398 NICWDEPENTGNSTIIYYVVEYQEIDTTEW-ISVKNITKTQTSIQNLKTNSSYRFRAYAV 1456
T + I VE E D E+ VK +T + + + S +
Sbjct: 959 T-----SSRTPSPQEIVLEVELSEKDVKEFEKQVKIVTVPEFTPDHKSMIVSLDVLPFNF 1013
Query: 1457 NEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWY 1516
+ ++ + K+ E P P+ + N D C G+P P+V WY
Sbjct: 1014 VDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWY 1073
Query: 1517 RDGKKLKTAKATY-----ENRXXXXXXXXXXXXXXXYKCIAFNDHGEV---------ETS 1562
++ ++ Y + Y+C A N GE ++
Sbjct: 1074 KEYMCIEPDNIKYVISEEKGSYTLKIRNVCLSDSATYRCRAVNCVGEAICRGFLTMGDSE 1133
Query: 1563 CVVGIQQKPVITISN--EDIKQKHKVGDEWLVTAVIEGIP 1600
I +K +T+S+ E++ K D + V+EG P
Sbjct: 1134 IFAVIAKKSKVTLSSLMEELVLKSNYTDSFFEFQVVEGPP 1173
Score = 47.6 bits (108), Expect = 5e-04
Identities = 67/289 (23%), Positives = 116/289 (40%), Gaps = 29/289 (10%)
Query: 1104 ELPPEIITRLQNQKVNKGNKATFEIELTKGDAL--VRWFKDGSEIQFSNHIQLTIDGKKQ 1161
E+PP I L +KV + F +E+ +G + V+W+++ S ++ I++ G
Sbjct: 839 EMPPSFIEPLTKRKVYENTTLGFIVEV-EGLPVPGVKWYRNKSLLEPDERIKMERVGNVC 897
Query: 1162 KLKIYDCDLDDAGEYSCE----VGNSKCTA---ILTVEE------PSIN------FTLRL 1202
L+I + + GEY C +G +K A I+ EE P + F L
Sbjct: 898 SLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEH 957
Query: 1203 PEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDD 1262
P+ + L VE+ ++ DV ++K+ I +FT D K + + +
Sbjct: 958 TTSSRTPSPQEIVLEVELSEK--DVKEFEKQVKIVTVPEFT--PDHKSMIVSLDVLPFNF 1013
Query: 1263 QCEYTCVLLDAKSTTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWI 1322
K+ +EV E PP+ + +++I SD P P +W
Sbjct: 1014 VDPNMDSREGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWY 1073
Query: 1323 VNSKIIKKCKHTKPSIDSKSASLTIK--KVENTDAGIYKLRLENNCGHA 1369
I+ + K I + S T+K V +D+ Y+ R N G A
Sbjct: 1074 KEYMCIEP-DNIKYVISEEKGSYTLKIRNVCLSDSATYRCRAVNCVGEA 1121
Score = 37.9 bits (84), Expect = 0.39
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 1596 IEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAG 1652
+EG+P P V WY+N + LE D+ + + I +++ +Y A N G
Sbjct: 865 VEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCSLEISNIQKGEGGEYMCHAVNIIG 921
Score = 37.9 bits (84), Expect = 0.39
Identities = 21/56 (37%), Positives = 30/56 (53%), Gaps = 1/56 (1%)
Query: 1598 GIPPPEVIWYKNGNKLENDKEYNITTKEKTS-VIRIKELKRSHSSKYTIEASNTAG 1652
GIP PEV WYK +E D + ++EK S ++I+ + S S+ Y A N G
Sbjct: 1064 GIPTPEVKWYKEYMCIEPDNIKYVISEEKGSYTLKIRNVCLSDSATYRCRAVNCVG 1119
Score = 37.9 bits (84), Expect = 0.39
Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 2/89 (2%)
Query: 1012 VKETIPEFIRKLQDFEVKEKDVAILEVEIN-SETADVVWERDGEIIKPKKNKYDFEKRGH 1070
V E P FI+ + D A + + S V W +DG++++ ++ + G
Sbjct: 1168 VVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQGRRFTVEESGTG- 1226
Query: 1071 IRKLYIRNTSVHDEGEYSCILRDESCTAE 1099
L+I + DEGEY C+ ++S AE
Sbjct: 1227 FHNLFITSLVKSDEGEYRCVATNKSGMAE 1255
Score = 35.9 bits (79), Expect = 1.6
Identities = 18/63 (28%), Positives = 27/63 (42%), Gaps = 4/63 (6%)
Query: 1503 CIFGGVPQPKVTWYRDGKKLKTAKATYENRXX----XXXXXXXXXXXXXYKCIAFNDHGE 1558
C+ G P+P V WY+DGK ++ + T E Y+C+A N G
Sbjct: 1194 CLVRGSPRPTVYWYKDGKLVQGRRFTVEESGTGFHNLFITSLVKSDEGEYRCVATNKSGM 1253
Query: 1559 VET 1561
E+
Sbjct: 1254 AES 1256
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.312 0.131 0.377
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 305,825,765
Number of Sequences: 224733
Number of extensions: 13134915
Number of successful extensions: 75587
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 919
Number of HSP's successfully gapped in prelim test: 1117
Number of HSP's that attempted gapping in prelim test: 37192
Number of HSP's gapped (non-prelim): 22064
length of query: 2130
length of database: 73,234,838
effective HSP length: 101
effective length of query: 2029
effective length of database: 50,536,805
effective search space: 102539177345
effective search space used: 102539177345
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (21.8 bits)
S2: 73 (33.5 bits)
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