Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000602-TA|BGIBMGA000602-PA|IPR000494|EGF receptor, L
domain, IPR006211|Furin-like cysteine rich region, IPR001245|Tyrosine
protein kinase, IPR011009|Protein kinase-like, IPR009030|Growth
factor, receptor, IPR000719|Protein kinase, IPR008266|Tyrosine protein
kinase, active site, IPR006212|Furin-like repeat
(1397 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P04412 Cluster: Epidermal growth factor receptor precur... 1453 0.0
UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;... 763 0.0
UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;... 722 0.0
UniRef50_Q6SAW1 Cluster: Epidermal growth factor receptor; n=70;... 666 0.0
UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23... 533 e-149
UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase... 498 e-139
UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4... 497 e-139
UniRef50_P00533 Cluster: Epidermal growth factor receptor precur... 472 e-131
UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2... 458 e-127
UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming pr... 447 e-123
UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3... 423 e-116
UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1; ... 420 e-115
UniRef50_Q5G254 Cluster: Erbb3; n=6; Danio rerio|Rep: Erbb3 - Da... 411 e-113
UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; ... 400 e-109
UniRef50_Q4RQT4 Cluster: Chromosome 2 SCAF15004, whole genome sh... 370 e-100
UniRef50_Q68KJ7 Cluster: HER2; n=3; Amniota|Rep: HER2 - Felis si... 367 1e-99
UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 330 2e-88
UniRef50_Q4RXV8 Cluster: Chromosome 11 SCAF14979, whole genome s... 322 3e-86
UniRef50_Q6SAX5 Cluster: Epidermal growth factor receptor; n=14;... 314 8e-84
UniRef50_UPI0000E47E88 Cluster: PREDICTED: similar to v-erb-a er... 312 4e-83
UniRef50_Q26566 Cluster: Epidermal growth factor receptor precur... 299 3e-79
UniRef50_Q5BXN9 Cluster: SJCHGC05493 protein; n=1; Schistosoma j... 283 2e-74
UniRef50_Q4SMB8 Cluster: Chromosome 3 SCAF14553, whole genome sh... 280 2e-73
UniRef50_Q4RW26 Cluster: Chromosome 9 SCAF14991, whole genome sh... 274 1e-71
UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus multilo... 259 4e-67
UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2; Cul... 238 9e-61
UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hyd... 233 3e-59
UniRef50_Q6QMR8 Cluster: EGFR8; n=3; Clupeocephala|Rep: EGFR8 - ... 232 4e-59
UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 232 4e-59
UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus ... 227 1e-57
UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA... 225 7e-57
UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep: Ty... 222 5e-56
UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2; Sop... 221 1e-55
UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to protein-ty... 219 3e-55
UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA... 219 6e-55
UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephr... 218 1e-54
UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein ty... 216 4e-54
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 216 4e-54
UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38; Eut... 216 4e-54
UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-onco... 214 2e-53
UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming pr... 214 2e-53
UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ... 214 2e-53
UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosi... 213 2e-53
UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 213 3e-53
UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2; Anthomedu... 213 3e-53
UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111; Euteleo... 213 3e-53
UniRef50_Q4S1Y7 Cluster: Chromosome undetermined SCAF14764, whol... 213 4e-53
UniRef50_UPI0000D563AD Cluster: PREDICTED: similar to CG3969-PA,... 212 5e-53
UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hyd... 211 9e-53
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 210 3e-52
UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming pr... 209 4e-52
UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=1... 209 5e-52
UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to tyrosine-p... 208 6e-52
UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack CG1499... 208 6e-52
UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24; Euteleo... 208 8e-52
UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like t... 207 1e-51
UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 206 3e-51
UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep... 206 3e-51
UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=3... 206 4e-51
UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13; Euteleo... 206 4e-51
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 205 6e-51
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 205 8e-51
UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga... 204 1e-50
UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep: CG1499... 204 2e-50
UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Eph... 204 2e-50
UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n... 203 2e-50
UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precurs... 203 3e-50
UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome s... 203 3e-50
UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whol... 202 4e-50
UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona intestinali... 202 4e-50
UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Da... 202 5e-50
UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome s... 202 5e-50
UniRef50_UPI00015B5A01 Cluster: PREDICTED: similar to protein ki... 202 7e-50
UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA... 201 9e-50
UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep: Zgc:1... 201 9e-50
UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep: ... 201 1e-49
UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47; E... 201 1e-49
UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep... 200 2e-49
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 200 2e-49
UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5; Cae... 200 2e-49
UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3; Culicidae|... 200 2e-49
UniRef50_A7RL50 Cluster: Predicted protein; n=1; Nematostella ve... 200 2e-49
UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54; Gnat... 200 2e-49
UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA;... 200 3e-49
UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whol... 200 3e-49
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 200 3e-49
UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family... 199 4e-49
UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome sh... 199 4e-49
UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep: E... 198 7e-49
UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55; E... 198 9e-49
UniRef50_Q7PT15 Cluster: ENSANGP00000009263; n=2; Culicidae|Rep:... 198 1e-48
UniRef50_Q9UK79 Cluster: Herstatin; n=1; Homo sapiens|Rep: Herst... 197 2e-48
UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=2... 197 2e-48
UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56; n... 197 2e-48
UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=3... 197 2e-48
UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|R... 196 3e-48
UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;... 196 5e-48
UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Re... 196 5e-48
UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6; Eume... 196 5e-48
UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 196 5e-48
UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome sh... 195 6e-48
UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n... 195 6e-48
UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23; Ther... 195 8e-48
UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=5... 195 8e-48
UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precurs... 194 1e-47
UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Re... 194 1e-47
UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=1... 194 1e-47
UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3; ... 194 1e-47
UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: E... 194 1e-47
UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|... 194 2e-47
UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n... 193 2e-47
UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precurs... 193 2e-47
UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome sh... 193 2e-47
UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -... 193 2e-47
UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma m... 193 2e-47
UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monos... 193 2e-47
UniRef50_O45232 Cluster: Putative uncharacterized protein ark-1;... 192 8e-47
UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK sp... 191 1e-46
UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor... 191 1e-46
UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma man... 190 2e-46
UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming pr... 190 2e-46
UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC 2.7... 190 3e-46
UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor recep... 190 3e-46
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 190 3e-46
UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precu... 190 3e-46
UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin... 189 4e-46
UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86; Coel... 189 4e-46
UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor precu... 189 4e-46
UniRef50_UPI0000E47C0F Cluster: PREDICTED: similar to focal adhe... 188 7e-46
UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA... 188 7e-46
UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,... 187 2e-45
UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-prote... 187 2e-45
UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon nigrovi... 186 3e-45
UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CS... 186 4e-45
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 186 5e-45
UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92... 186 5e-45
UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome sh... 186 5e-45
UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Cion... 186 5e-45
UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to ENSANGP000... 185 9e-45
UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 185 9e-45
UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5; Eutel... 185 9e-45
UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:... 184 1e-44
UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ... 184 1e-44
UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2; C... 184 2e-44
UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP099... 184 2e-44
UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella ve... 184 2e-44
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 184 2e-44
UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1 pre... 184 2e-44
UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9; Cl... 183 3e-44
UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21; Deut... 183 3e-44
UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora... 182 5e-44
UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gamb... 182 5e-44
UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 182 6e-44
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 182 8e-44
UniRef50_Q25410 Cluster: Putative molluscan insulin-related pept... 182 8e-44
UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX... 182 8e-44
UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:1... 181 1e-43
UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella ve... 181 1e-43
UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77; E... 181 1e-43
UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC ... 180 2e-43
UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;... 179 4e-43
UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 179 4e-43
UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming pr... 179 4e-43
UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6; En... 179 6e-43
UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase ... 179 6e-43
UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte ... 178 8e-43
UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca CG... 178 8e-43
UniRef50_Q4S1M5 Cluster: Chromosome 6 SCAF14768, whole genome sh... 178 1e-42
UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona intestinali... 178 1e-42
UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-onco... 177 1e-42
UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin re... 177 1e-42
UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32; Eute... 177 1e-42
UniRef50_Q4SF69 Cluster: Chromosome undetermined SCAF14608, whol... 177 2e-42
UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Re... 177 2e-42
UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=... 177 2e-42
UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p, ... 177 2e-42
UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kin... 177 2e-42
UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular ... 177 2e-42
UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae... 177 2e-42
UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella ve... 177 2e-42
UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosin... 176 3e-42
UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep: M... 176 3e-42
UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4; Endoptery... 176 3e-42
UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1; ... 176 3e-42
UniRef50_UPI00006A1E7A Cluster: Non-receptor tyrosine-protein ki... 176 4e-42
UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor... 176 4e-42
UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whol... 175 5e-42
UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n... 175 5e-42
UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2; ... 175 7e-42
UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Re... 175 7e-42
UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase ... 175 7e-42
UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,... 175 9e-42
UniRef50_O61460 Cluster: Ephrin receptor 1 precursor; n=3; Caeno... 175 9e-42
UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2 pre... 175 9e-42
UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein ... 174 1e-41
UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta ... 174 1e-41
UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hy... 174 1e-41
UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberite... 174 1e-41
UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250... 174 2e-41
UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;... 173 3e-41
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 173 3e-41
UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona ... 173 3e-41
UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1; ... 173 4e-41
UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 173 4e-41
UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella ve... 173 4e-41
UniRef50_UPI0000E4A99A Cluster: PREDICTED: similar to tyrosine k... 172 5e-41
UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2; ... 172 5e-41
UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase ... 172 5e-41
UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane r... 172 5e-41
UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1; ... 172 7e-41
UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1 pre... 172 7e-41
UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3; ... 171 9e-41
UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella ve... 171 9e-41
UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase ... 171 9e-41
UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homol... 171 9e-41
UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;... 171 1e-40
UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1 ... 171 2e-40
UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;... 170 2e-40
UniRef50_Q13470 Cluster: Non-receptor tyrosine-protein kinase TN... 170 3e-40
UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homol... 170 3e-40
UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:... 170 3e-40
UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n... 169 4e-40
UniRef50_UPI000065E56D Cluster: EPHB1_HUMAN Isoform 3 of P54762 ... 169 4e-40
UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella ve... 169 4e-40
UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=... 169 4e-40
UniRef50_Q01974 Cluster: Tyrosine-protein kinase transmembrane r... 169 4e-40
UniRef50_Q25198 Cluster: Receptor tyrosine kinase 90; n=1; Hydra... 169 5e-40
UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 168 8e-40
UniRef50_UPI0000DB7B4C Cluster: PREDICTED: similar to hopscotch ... 168 1e-39
UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2; ... 168 1e-39
UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome sh... 167 1e-39
UniRef50_O60674 Cluster: Tyrosine-protein kinase JAK2; n=48; Eut... 167 1e-39
UniRef50_Q10925-2 Cluster: Isoform b of Q10925 ; n=2; Caenorhabd... 167 2e-39
UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|... 167 2e-39
UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3; Eutheria... 167 2e-39
UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase ... 167 2e-39
UniRef50_Q10925 Cluster: Probable tyrosine-protein kinase kin-25... 167 2e-39
UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to ENSANGP000... 167 2e-39
UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whol... 167 2e-39
UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gamb... 167 2e-39
UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic... 166 3e-39
UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5; ... 166 3e-39
UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome s... 166 3e-39
UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Cio... 166 3e-39
UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella ve... 166 3e-39
UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome sh... 165 6e-39
UniRef50_Q4SFK0 Cluster: Chromosome 7 SCAF14601, whole genome sh... 165 6e-39
UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1... 165 6e-39
UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4 var... 165 8e-39
UniRef50_Q15516 Cluster: Tyrosine kinase; n=1; Homo sapiens|Rep:... 165 8e-39
UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO pr... 165 8e-39
UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca precur... 165 8e-39
UniRef50_P52333 Cluster: Tyrosine-protein kinase JAK3; n=17; Eut... 165 1e-38
UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-li... 164 1e-38
UniRef50_Q9PWD1 Cluster: Tyrosine-protein kinase; n=3; Tetraodon... 164 1e-38
UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin re... 164 2e-38
UniRef50_UPI0000D56AE3 Cluster: PREDICTED: similar to CG1594-PA;... 164 2e-38
UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5; Caenorha... 164 2e-38
UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|R... 163 4e-38
UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor precu... 163 4e-38
UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine p... 162 5e-38
UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;... 162 5e-38
UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2 pre... 162 5e-38
UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1; Gir... 162 7e-38
UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor prec... 162 7e-38
UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4 pre... 162 7e-38
UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 161 9e-38
UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor precu... 161 1e-37
UniRef50_UPI00005A2D48 Cluster: PREDICTED: similar to EPH recept... 161 2e-37
UniRef50_Q6W5B1 Cluster: TEL/JAK2 fusion protein; n=4; Danio rer... 161 2e-37
UniRef50_Q6GPK5 Cluster: Tyrosine-protein kinase; n=4; Euteleost... 161 2e-37
UniRef50_Q23554 Cluster: Putative uncharacterized protein; n=1; ... 161 2e-37
UniRef50_Q5JZY3 Cluster: Ephrin type-A receptor 10 precursor; n=... 161 2e-37
UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle spe... 160 2e-37
UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 160 2e-37
UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 160 3e-37
UniRef50_P14616 Cluster: Insulin receptor-related protein precur... 160 3e-37
UniRef50_Q4RU24 Cluster: Chromosome 12 SCAF14996, whole genome s... 159 4e-37
UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 159 4e-37
UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella ve... 159 4e-37
UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3 ... 159 4e-37
UniRef50_P23458 Cluster: Tyrosine-protein kinase JAK1; n=55; Eut... 159 4e-37
UniRef50_O12990 Cluster: Tyrosine-protein kinase Jak1; n=8; Eute... 159 4e-37
UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase recepto... 159 5e-37
UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1... 159 5e-37
UniRef50_Q9PTN6 Cluster: Tyrosine-protein kinase; n=9; Euteleost... 159 7e-37
UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1; ... 159 7e-37
UniRef50_Q26614 Cluster: Fibroblast growth factor receptor precu... 159 7e-37
UniRef50_UPI0000DB7A0A Cluster: PREDICTED: similar to FMS-like t... 158 9e-37
UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror CG4926... 158 1e-36
UniRef50_Q9N3S5 Cluster: Putative uncharacterized protein; n=4; ... 158 1e-36
UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane r... 158 1e-36
UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11; Mammal... 158 1e-36
UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1... 157 2e-36
UniRef50_Q70W12 Cluster: Discoidin receptor; n=1; Ciona intestin... 157 2e-36
UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; ... 157 2e-36
UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41... 157 2e-36
UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;... 157 2e-36
UniRef50_UPI00015B6363 Cluster: PREDICTED: similar to tyrosine p... 157 2e-36
UniRef50_UPI000065E468 Cluster: Homolog of Gallus gallus "Ephrin... 157 2e-36
UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12; Euar... 157 2e-36
UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine prot... 157 2e-36
UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2; ... 157 3e-36
UniRef50_P29597 Cluster: Non-receptor tyrosine-protein kinase TY... 157 3e-36
UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor p... 157 3e-36
UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whol... 156 4e-36
UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2; ... 156 4e-36
UniRef50_P04629 Cluster: High affinity nerve growth factor recep... 156 4e-36
UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane r... 156 5e-36
UniRef50_Q16832 Cluster: Discoidin domain-containing receptor 2 ... 156 5e-36
UniRef50_Q4SUM3 Cluster: Ephrin receptor; n=4; Tetraodon nigrovi... 155 6e-36
UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n... 155 6e-36
UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor p... 155 8e-36
UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-li... 155 1e-35
UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor; ... 155 1e-35
UniRef50_O76997 Cluster: Putative neurotrophin receptor LTRK 1 p... 154 2e-35
UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like pro... 153 2e-35
UniRef50_O16131 Cluster: Insulin receptor homolog precursor; n=2... 153 2e-35
UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin re... 153 3e-35
UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole... 153 3e-35
UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=5... 153 4e-35
UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor precu... 152 6e-35
UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella ve... 152 8e-35
UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC 2.7... 152 8e-35
UniRef50_Q4T1R9 Cluster: Chromosome 4 SCAF10492, whole genome sh... 151 1e-34
UniRef50_A6NFC2 Cluster: Uncharacterized protein ERBB2; n=2; Mam... 151 1e-34
UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2; S... 151 1e-34
UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2; ... 151 1e-34
UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella ve... 151 1e-34
UniRef50_Q9Y1Y8 Cluster: Protein tyrosine kinase; n=2; Metazoa|R... 150 2e-34
UniRef50_O17391 Cluster: Protein kinase protein 9, isoform b; n=... 150 2e-34
UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=... 150 2e-34
UniRef50_Q16RK6 Cluster: Receptor protein tyrosine kinase; n=1; ... 150 3e-34
UniRef50_A4RXI8 Cluster: Predicted protein; n=2; Ostreococcus|Re... 149 4e-34
UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2; ... 149 4e-34
UniRef50_O76411 Cluster: Suppressor of constitutive dauer format... 149 4e-34
UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor ... 149 5e-34
UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor t... 149 7e-34
UniRef50_Q61B52 Cluster: Putative uncharacterized protein CBG134... 149 7e-34
UniRef50_Q674V1 Cluster: Vascular endothelial growth factor rece... 148 9e-34
UniRef50_Q16LR4 Cluster: Tyrosine protein kinase; n=5; Coelomata... 148 9e-34
UniRef50_Q96HF4 Cluster: EPHA2 protein; n=3; Amniota|Rep: EPHA2 ... 148 9e-34
UniRef50_UPI00015B5C00 Cluster: PREDICTED: similar to VEGFR-A sp... 148 1e-33
UniRef50_Q22489 Cluster: Putative uncharacterized protein; n=4; ... 148 1e-33
UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2; Culicidae... 148 1e-33
UniRef50_O01325 Cluster: Putative uncharacterized protein; n=2; ... 148 1e-33
UniRef50_UPI00015B54DC Cluster: PREDICTED: similar to vascular e... 147 2e-33
UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin re... 147 2e-33
UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whol... 147 2e-33
UniRef50_A1IKE0 Cluster: Receptor tyrosine kinase-like orphan re... 147 2e-33
UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine prot... 147 2e-33
UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protei... 146 3e-33
UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome s... 146 3e-33
UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor... 146 3e-33
UniRef50_Q4H3A3 Cluster: Janus kinase; n=1; Ciona intestinalis|R... 146 3e-33
UniRef50_Q5RIU8 Cluster: Novel protein similar to vertebrate dis... 146 4e-33
UniRef50_P18475 Cluster: Tyrosine-protein kinase receptor torso ... 146 4e-33
UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella ve... 146 5e-33
UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor... 146 5e-33
UniRef50_O15197 Cluster: Ephrin type-B receptor 6 precursor; n=2... 145 7e-33
UniRef50_UPI000065F9C5 Cluster: Epithelial discoidin domain-cont... 145 9e-33
UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4; Caenorhabd... 145 9e-33
UniRef50_Q0IFX6 Cluster: Pdgf/vegf receptor; n=1; Aedes aegypti|... 145 9e-33
UniRef50_P36888 Cluster: FL cytokine receptor precursor; n=33; A... 145 9e-33
UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15 ... 145 9e-33
UniRef50_Q9GRH2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 144 1e-32
UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12; Tetr... 144 2e-32
UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3; ... 144 2e-32
UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690; ... 144 2e-32
UniRef50_UPI00006A26D5 Cluster: UPI00006A26D5 related cluster; n... 144 2e-32
UniRef50_Q9VLQ8 Cluster: CG8222-PA, isoform A; n=8; Sophophora|R... 144 2e-32
UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine ki... 144 2e-32
UniRef50_Q8T4M0 Cluster: VEGFR-A splice form A; n=4; Diptera|Rep... 144 2e-32
UniRef50_UPI0000E470E3 Cluster: PREDICTED: similar to Fer, parti... 143 3e-32
UniRef50_Q7Q0U2 Cluster: ENSANGP00000012311; n=1; Anopheles gamb... 143 3e-32
UniRef50_Q55GU0 Cluster: Protein kinase, TKL group; n=1; Dictyos... 143 3e-32
UniRef50_UPI0000E47A46 Cluster: PREDICTED: similar to ret protei... 142 5e-32
UniRef50_Q8IQ00 Cluster: CG3277-PB, isoform B; n=3; Sophophora|R... 142 5e-32
UniRef50_Q9U8U8 Cluster: VEGFR-like; n=1; Branchiostoma belcheri... 142 6e-32
UniRef50_Q5CVX5 Cluster: Ser/Thr protein kinase with MORN repeat... 142 6e-32
UniRef50_A7SIN7 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 142 6e-32
UniRef50_UPI0000F1E1C1 Cluster: PREDICTED: hypothetical protein;... 142 8e-32
UniRef50_UPI00015B5DE3 Cluster: PREDICTED: hypothetical protein;... 141 1e-31
UniRef50_Q5Z986 Cluster: EDR1-like; n=3; Magnoliophyta|Rep: EDR1... 141 1e-31
UniRef50_Q9Y1Y0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 141 1e-31
UniRef50_O17408 Cluster: Putative uncharacterized protein; n=1; ... 141 1e-31
UniRef50_P17948 Cluster: Vascular endothelial growth factor rece... 141 1e-31
UniRef50_Q9TYX4 Cluster: Putative uncharacterized protein R11E3.... 141 1e-31
UniRef50_Q8T0W6 Cluster: Putative insulin receptor precursor; n=... 141 1e-31
UniRef50_Q17IF1 Cluster: Receptor protein tyrosine kinase; n=1; ... 141 1e-31
UniRef50_UPI000155CF4D Cluster: PREDICTED: similar to EPH recept... 140 2e-31
UniRef50_UPI0000499A85 Cluster: protein kinase; n=1; Entamoeba h... 140 2e-31
UniRef50_Q4RHE1 Cluster: Chromosome 3 SCAF15050, whole genome sh... 140 2e-31
UniRef50_P07333 Cluster: Macrophage colony-stimulating factor 1 ... 140 2e-31
UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18; Eu... 140 2e-31
UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precurso... 140 2e-31
UniRef50_Q17833 Cluster: Putative uncharacterized protein old-1;... 140 3e-31
UniRef50_UPI0000DB74F2 Cluster: PREDICTED: similar to Derailed 2... 139 4e-31
UniRef50_Q4TFI7 Cluster: Chromosome undetermined SCAF4439, whole... 139 4e-31
UniRef50_Q4SJQ3 Cluster: Tyrosine-protein kinase receptor; n=1; ... 139 4e-31
UniRef50_P80192 Cluster: Mitogen-activated protein kinase kinase... 139 4e-31
UniRef50_Q08345 Cluster: Epithelial discoidin domain-containing ... 139 4e-31
UniRef50_Q9M085 Cluster: Protein kinase-like protein; n=22; Magn... 139 6e-31
UniRef50_A7RGV3 Cluster: Predicted protein; n=1; Nematostella ve... 139 6e-31
UniRef50_Q9N4T2 Cluster: Putative uncharacterized protein Y50D4B... 138 8e-31
UniRef50_UPI0000D576E5 Cluster: PREDICTED: similar to CG33531-PA... 138 1e-30
UniRef50_Q4RPK6 Cluster: Chromosome 12 SCAF15007, whole genome s... 138 1e-30
UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 138 1e-30
UniRef50_Q21038 Cluster: Putative uncharacterized protein ver-3;... 138 1e-30
UniRef50_P35968 Cluster: Vascular endothelial growth factor rece... 138 1e-30
UniRef50_UPI00015535B8 Cluster: PREDICTED: similar to mixed line... 138 1e-30
UniRef50_Q95ZV7 Cluster: Putative uncharacterized protein; n=3; ... 138 1e-30
UniRef50_Q16584 Cluster: Mitogen-activated protein kinase kinase... 137 2e-30
UniRef50_UPI0000E49AD1 Cluster: PREDICTED: similar to mixed line... 137 2e-30
UniRef50_UPI0000DB7571 Cluster: PREDICTED: similar to mitogen-ac... 137 2e-30
UniRef50_Q25199 Cluster: Tyrosine kinase receptor; n=7; Hydra|Re... 137 2e-30
UniRef50_Q4JDD5 Cluster: Tyrosine-protein kinase receptor; n=5; ... 136 3e-30
UniRef50_Q0MQ66 Cluster: Putative uncharacterized protein; n=5; ... 136 3e-30
UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella ve... 136 4e-30
UniRef50_Q3U1V8 Cluster: Mitogen-activated protein kinase kinase... 136 4e-30
UniRef50_Q19726 Cluster: Putative uncharacterized protein kin-14... 136 5e-30
UniRef50_P34265 Cluster: Probable tyrosine-protein kinase kin-31... 135 9e-30
UniRef50_Q640T5 Cluster: Tyrosine-protein kinase receptor; n=2; ... 134 1e-29
UniRef50_Q4L0H7 Cluster: Insulin receptor tyrosine kinase; n=2; ... 134 1e-29
UniRef50_UPI0000D8BE91 Cluster: UPI0000D8BE91 related cluster; n... 134 2e-29
UniRef50_O02064 Cluster: Putative uncharacterized protein; n=1; ... 134 2e-29
UniRef50_P35916 Cluster: Vascular endothelial growth factor rece... 134 2e-29
UniRef50_Q60WJ5 Cluster: Putative uncharacterized protein CBG191... 134 2e-29
UniRef50_Q16VL6 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 133 3e-29
UniRef50_UPI00015B55E4 Cluster: PREDICTED: similar to receptor-l... 133 4e-29
UniRef50_UPI0000F1F986 Cluster: PREDICTED: similar to mixed line... 133 4e-29
UniRef50_Q9U8U9 Cluster: PDGFR-like; n=1; Eptatretus burgeri|Rep... 132 5e-29
UniRef50_P91360 Cluster: Putative uncharacterized protein; n=1; ... 132 5e-29
UniRef50_Q24592 Cluster: Tyrosine-protein kinase hopscotch; n=2;... 132 5e-29
UniRef50_Q9U3B5 Cluster: Putative uncharacterized protein; n=3; ... 132 7e-29
UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1; ... 132 7e-29
UniRef50_O17755 Cluster: Putative uncharacterized protein; n=3; ... 132 7e-29
UniRef50_A7RNB2 Cluster: Predicted protein; n=1; Nematostella ve... 132 7e-29
UniRef50_A0CL90 Cluster: Chromosome undetermined scaffold_20, wh... 132 7e-29
UniRef50_Q02779 Cluster: Mitogen-activated protein kinase kinase... 132 7e-29
UniRef50_Q9I8N6 Cluster: Macrophage colony-stimulating factor 1 ... 132 7e-29
UniRef50_UPI0000D560EA Cluster: PREDICTED: similar to CG31127-PA... 132 9e-29
UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistos... 132 9e-29
UniRef50_O76809 Cluster: Receptor tyrosine kinase HTK30; n=1; Hy... 132 9e-29
UniRef50_Q8UVR8 Cluster: Macrophage colony-stimulating factor 1 ... 132 9e-29
UniRef50_Q61CN6 Cluster: Putative uncharacterized protein CBG128... 131 1e-28
UniRef50_Q4H377 Cluster: Mitogen-activated protein kinase kinase... 131 1e-28
UniRef50_Q9V422 Cluster: Tyrosine-protein kinase Dnt precursor; ... 131 1e-28
UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2; ... 131 2e-28
UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 131 2e-28
UniRef50_Q8AXB3 Cluster: Vascular endothelial growth factor rece... 131 2e-28
UniRef50_Q0P4R9 Cluster: Discoidin domain receptor family, membe... 130 2e-28
UniRef50_Q012D5 Cluster: Tyrosine kinase specific for activated ... 130 2e-28
UniRef50_Q1HTP1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 130 3e-28
UniRef50_P16234 Cluster: Alpha-type platelet-derived growth fact... 130 3e-28
UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Re... 129 5e-28
UniRef50_Q17HL3 Cluster: Discoidin domain receptor; n=3; Culicid... 129 5e-28
UniRef50_UPI0000585FA7 Cluster: PREDICTED: similar to leucine zi... 129 6e-28
UniRef50_Q9C833 Cluster: Protein kinase, putative; 42705-46677; ... 129 6e-28
UniRef50_Q9Y1X7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 129 6e-28
UniRef50_Q9Y1Y4 Cluster: Tyrosine-protein kinase; n=1; Ephydatia... 128 8e-28
UniRef50_Q19238 Cluster: Putative tyrosine-protein kinase F09A5.... 128 8e-28
UniRef50_UPI00015B629D Cluster: PREDICTED: similar to CG33531-PA... 128 1e-27
UniRef50_Q8ITG6 Cluster: Focal adhesion kinase; n=2; Protostomia... 128 1e-27
UniRef50_P10721 Cluster: Mast/stem cell growth factor receptor p... 128 1e-27
UniRef50_P34892 Cluster: Receptor-like tyrosine-protein kinase k... 128 1e-27
UniRef50_A4S2A1 Cluster: Predicted protein; n=1; Ostreococcus lu... 128 1e-27
UniRef50_Q7JQT0 Cluster: GH27039p; n=4; Diptera|Rep: GH27039p - ... 128 1e-27
UniRef50_Q23102 Cluster: Putative uncharacterized protein; n=1; ... 128 1e-27
UniRef50_Q54RZ7 Cluster: MORN repeat-containing protein; n=1; Di... 127 2e-27
UniRef50_UPI00015B55E2 Cluster: PREDICTED: similar to tyrosine-p... 126 3e-27
UniRef50_UPI0000DB7238 Cluster: PREDICTED: similar to Discoidin ... 126 3e-27
UniRef50_O82754 Cluster: Putative serine/threonine kinase; n=2; ... 126 3e-27
UniRef50_Q5GIT4 Cluster: Vascular endothelial growth factor rece... 126 3e-27
UniRef50_Q8JFR5 Cluster: Mast/stem cell growth factor receptor p... 126 3e-27
UniRef50_Q9NYL2 Cluster: Mitogen-activated protein kinase kinase... 126 4e-27
UniRef50_Q95UN8 Cluster: Mitogen-activated protein kinase kinase... 126 4e-27
UniRef50_UPI00015B6067 Cluster: PREDICTED: similar to tyrosine p... 126 6e-27
UniRef50_UPI000155F437 Cluster: PREDICTED: similar to Mitogen ac... 126 6e-27
UniRef50_Q27324 Cluster: Tyrosine-protein kinase Drl precursor; ... 126 6e-27
UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole... 125 7e-27
UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4; ... 125 7e-27
UniRef50_A2DI38 Cluster: TKL family protein kinase; n=2; Trichom... 125 7e-27
UniRef50_UPI000065D0F4 Cluster: Mitogen-activated protein kinase... 125 1e-26
UniRef50_Q8I7I5 Cluster: Roller: helically twisted, animals roll... 125 1e-26
UniRef50_Q5TRF2 Cluster: ENSANGP00000025511; n=1; Anopheles gamb... 125 1e-26
UniRef50_A7RWY4 Cluster: Predicted protein; n=1; Nematostella ve... 125 1e-26
UniRef50_P34891 Cluster: Receptor-like tyrosine-protein kinase k... 124 1e-26
UniRef50_UPI00005011B5 Cluster: UPI00005011B5 related cluster; n... 124 2e-26
UniRef50_Q9LMF8 Cluster: F16A14.22; n=9; Magnoliophyta|Rep: F16A... 124 2e-26
UniRef50_Q59DZ7 Cluster: CG33531-PA; n=6; Sophophora|Rep: CG3353... 124 2e-26
UniRef50_UPI0000DB72A0 Cluster: PREDICTED: similar to R151.4a; n... 124 2e-26
UniRef50_Q259N0 Cluster: H0723C07.13 protein; n=4; Oryza sativa|... 123 4e-26
UniRef50_UPI0000F1F8B4 Cluster: PREDICTED: hypothetical protein;... 122 5e-26
UniRef50_UPI0000E257E1 Cluster: PREDICTED: similar to tyrosine k... 122 5e-26
UniRef50_Q9SZM7 Cluster: Protein kinase like protein; n=1; Arabi... 122 5e-26
UniRef50_P79749 Cluster: Beta-type platelet-derived growth facto... 122 5e-26
UniRef50_Q2MHE4 Cluster: Serine/threonine-protein kinase HT1; n=... 122 5e-26
UniRef50_UPI00015B629F Cluster: PREDICTED: similar to CG33531-PA... 122 9e-26
UniRef50_A2DXP4 Cluster: TKL family protein kinase; n=1; Trichom... 122 9e-26
>UniRef50_P04412 Cluster: Epidermal growth factor receptor precursor;
n=129; Endopterygota|Rep: Epidermal growth factor
receptor precursor - Drosophila melanogaster (Fruit fly)
Length = 1426
Score = 1453 bits (3600), Expect = 0.0
Identities = 661/1152 (57%), Positives = 827/1152 (71%), Gaps = 18/1152 (1%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+SVPSN++ HYRNLRDR+TNCTYVDGNL+LTWL NE++DLSFL IREVTGY+LISHV V
Sbjct: 109 LSVPSNKEHHYRNLRDRYTNCTYVDGNLKLTWLPNENLDLSFLDNIREVTGYILISHVDV 168
Query: 61 HKIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSVGIYSNFNLC 120
K+V P+LQIIRGRTLF L+V EE++AL VT S +TLE+P LRDVL G VG ++N+NLC
Sbjct: 169 KKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLC 228
Query: 121 HVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKTICSPQ 180
H++TI W EI + T + + + + GE +NCQKFSK CSPQ
Sbjct: 229 HMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQKFSKLTCSPQ 288
Query: 181 CAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQIYNPTTYSW 240
CA GRC+GP PR+CC+ FCAGGCTGP C+AC+NF+DE +ECP M+ YNPTTY
Sbjct: 289 CAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVL 348
Query: 241 EPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAVNGECIPCVGTCPKTCRAEKP 300
E NP GKYAYGATCV+ CP HLL+DNGACVRSCP +K GEC+PC G CPKTC
Sbjct: 349 ETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTV 408
Query: 301 IHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALEVFSTVREVT 360
+H+GNIDSF++CT+IDG+I IL+ TF+GFQ V +Y+ G RY ++P+ EVFSTV+E+T
Sbjct: 409 LHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERREVFSTVKEIT 468
Query: 361 GYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXXXXXXXXXXXVNSGAI 420
GYLN++ HP F +LSYFRNLE I GRQ++E++FA+L IVK+ ++SG++
Sbjct: 469 GYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSV 528
Query: 421 AIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNLVCDPQCSADGCWGPGPD 480
I NR+LCY I W + K + K + +N CEKN +C QC+ DGCWG G D
Sbjct: 529 VIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTD 588
Query: 481 QCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCTGASRANCTSCKHVRDG 540
QCL+C+N+NF CI +C YK D+++CK CH EC C GA +C C HVRDG
Sbjct: 589 QCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRT-CNGAGADHCQECVHVRDG 647
Query: 541 PYCVAQCPESRYASEXXXXXXXXXXXXXXXXXXANTVGEGGCNSCNKAIISVEATVESCL 600
+CV++CP+++Y +T+G G C +CN AII+ +ATV+ CL
Sbjct: 648 QHCVSECPKNKYNDRGVCRECHATCDGCTGPK--DTIGIGACTTCNLAIINNDATVKRCL 705
Query: 601 KEDEPCPDGYYNEWV-----GNVKPLEGKVKIACRKCHPLCIKCVGFGIHEQVCQVCNGF 655
+D+ CPDGY+ E+V G++KPL G+ CRKCHPLC C +G HEQVC C +
Sbjct: 706 LKDDKCPDGYFWEYVHPQEQGSLKPLAGRA--VCRKCHPLCELCTNYGYHEQVCSKCTHY 763
Query: 656 KRGDQCEDECPSDHFTDEIGRNCTPCHSECKGCTGPGPTDCIKCKNLKIFLGGSDASDEN 715
KR +QCE ECP+DH+TDE R C H EC GCTGPG DC C+N K+F N
Sbjct: 764 KRREQCETECPADHYTDEEQRECFQRHPECNGCTGPGADDCKSCRNFKLFDANETGPYVN 823
Query: 716 AP-FNCTDTCPDNIPNKIYFDEQLQDPIEEPYCSEHANDIPTATARTSTVLVIILVIASL 774
+ FNCT CP + + Y Q PYC+ TA ++ I+ A L
Sbjct: 824 STMFNCTSKCPLEMRHVNY-----QYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVL 878
Query: 775 F--LAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAEL 832
+ +L ++ Y RQK KAKKE VKMTM L+GCED+EPLRP+N+ NL KLRIVK+AEL
Sbjct: 879 VPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAEL 938
Query: 833 RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHP 892
R+GG+LG GAFG+VYKGVWVPEGENVKIPVAIK L ++TGA +S+EFL EAYIMAS EH
Sbjct: 939 RKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHV 998
Query: 893 NLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKR 952
NLL+LLAVCM++QMMLITQLMPLGCL+DYVR +++KIGSKA LNW TQIA+GM+YLEEKR
Sbjct: 999 NLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKR 1058
Query: 953 LVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFT 1012
LVHRDLAARNVLVQTP+ VKITDFGLAKLL + +EYKAAGGKMPIKWLALECI++R+FT
Sbjct: 1059 LVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFT 1118
Query: 1013 HKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWM 1072
KSDVWAFGVTIWE+L++G RP+ENI A+++P+LIE GLKL QP IC+LDIYC ++SCW
Sbjct: 1119 SKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWH 1178
Query: 1073 LDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPE 1132
LDA RPTFKQL FAE ARDPGRYL IPGDKF RLP+Y++QDEK++IR L+ +G E
Sbjct: 1179 LDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSE 1238
Query: 1133 SLVDADEYLQPK 1144
++ D+YLQPK
Sbjct: 1239 AIAKPDDYLQPK 1250
Score = 100 bits (240), Expect = 2e-19
Identities = 62/167 (37%), Positives = 83/167 (49%), Gaps = 13/167 (7%)
Query: 1230 SRYCSDPMKTRTEVSLEDNFDGMSKAKEAQVGNLKLNLPLDEDDYLMPSPQHTQNASTYM 1289
+RYC DP + +D D S A+E VGNL+L+LP+DEDDYLMP+ Q N + M
Sbjct: 1269 NRYCKDPSNKNSSTG-DDERD--SSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNM 1325
Query: 1290 DLISEGCEGQDVNDIRFGEFVSSKRCIDNPEYLMSEESVPPQTLGIPTEPVPXXXXXXXX 1349
+ ++ + + + +DNPEYL++ QTLG+ P+P
Sbjct: 1326 NNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNA-----QTLGVGESPIPTQTIGIPV 1380
Query: 1350 XXXDTTPRPGTSNYMPQRSVEEESMSDHEYYNDLQRELQPLRRNETT 1396
PGT E + SDHEYYND QRELQPL RN T
Sbjct: 1381 MGG-----PGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNT 1422
>UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;
Diptera|Rep: Epidermal growth factor receptor -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 763 bits (1887), Expect = 0.0
Identities = 361/630 (57%), Positives = 445/630 (70%), Gaps = 17/630 (2%)
Query: 523 CTGASRANCTSCKHVRDGPYCVAQCPESRYASEXXXXXXXXXXXXXXXXXXANTVGEGGC 582
C GA +C C HVRDG +CV++CP+++Y +T+G G C
Sbjct: 529 CNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPK--DTIGIGAC 586
Query: 583 NSCNKAIISVEATVESCLKEDEPCPDGYYNEWV-----GNVKPLEGKVKIACRKCHPLCI 637
+CN AII+ +ATV+ CL +D+ CPDGY+ E+V G++KPL G+ CRKCHPLC
Sbjct: 587 TTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRA--VCRKCHPLCE 644
Query: 638 KCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECKGCTGPGPTDCI 697
C +G HEQVC C +KR +QCE ECP+DH+TDE R C CH EC GCTGPG DC
Sbjct: 645 LCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCK 704
Query: 698 KCKNLKIFLGGSDASDENAP-FNCTDTCPDNIPNKIYFDEQLQDPIEEPYCSEHANDIPT 756
C+N K+F N+ FNCT CP + + Y Q PYC+
Sbjct: 705 SCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNY-----QYTAIGPYCAASPPRSSK 759
Query: 757 ATARTSTVLVIILVIASLF--LAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRP 814
TA ++ I+ A L + +L ++ Y RQK KAKKE VKMTM L+GCED+EPLRP
Sbjct: 760 ITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRP 819
Query: 815 TNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGAN 874
+N+ NL KLRIVK+AELR+GG+LG GAFG+VYKGVWVPEGENVKIPVAIK L ++TGA
Sbjct: 820 SNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAE 879
Query: 875 TSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
+S+EFL EAYIMA L+LLAVCM++QMMLITQLMPLGCL+DYVR +++KIGSKA
Sbjct: 880 SSEEFLREAYIMAXXXXXXXLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKAL 939
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG 994
LNW TQIA+GM+YLEEKRLVHRDLAARNVLVQTP+ VKITDFGLAKLL + +EYKAAGG
Sbjct: 940 LNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGG 999
Query: 995 KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLP 1054
KMPIKWLALECI++R+FT KSDVWAFGVTIWE+L++G RP+ENI A+++P+LIE GLKL
Sbjct: 1000 KMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLE 1059
Query: 1055 QPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPSYST 1114
QP IC+LDIYC ++SCW LDA RPTFKQL FAE ARDPGRYL IPGD
Sbjct: 1060 QPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDXXXXXXXXXX 1119
Query: 1115 QDEKEMIRNLSSAMEGPESLVDADEYLQPK 1144
EK++IR L+ +G E++ + D+YLQPK
Sbjct: 1120 XXEKDLIRKLAPTTDGSEAIAEPDDYLQPK 1149
Score = 496 bits (1224), Expect = e-138
Identities = 214/352 (60%), Positives = 264/352 (75%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+SVPSN++ HYRNLRDR+TNCTYVDGNLELTWL NE++DLSFL IREVTGY+LISHV V
Sbjct: 8 LSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISHVDV 67
Query: 61 HKIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSVGIYSNFNLC 120
K+V P+LQIIRGRTLF L+V EE++AL VT S +TLE+P LRDVL G VG ++N+NLC
Sbjct: 68 KKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLC 127
Query: 121 HVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKTICSPQ 180
H++TI W EI + T + + + + GE +NCQKFSK CSPQ
Sbjct: 128 HMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQKFSKLTCSPQ 187
Query: 181 CAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQIYNPTTYSW 240
CA GRC+GP PR+CC+ FCAGGCTGP C+AC+NF+DEG C +ECP M+ YNPTTY
Sbjct: 188 CAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVL 247
Query: 241 EPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAVNGECIPCVGTCPKTCRAEKP 300
E NP GKYAYGATCV+ CP HLL+DNGACVRSCP +K GEC+PC G CPKTC
Sbjct: 248 ETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTV 307
Query: 301 IHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALEV 352
+H+GNIDSF++CT+IDG+I IL+ TF+GFQ V +Y+ G RY ++P+ LEV
Sbjct: 308 LHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEV 359
Score = 101 bits (241), Expect = 2e-19
Identities = 62/167 (37%), Positives = 83/167 (49%), Gaps = 13/167 (7%)
Query: 1230 SRYCSDPMKTRTEVSLEDNFDGMSKAKEAQVGNLKLNLPLDEDDYLMPSPQHTQNASTYM 1289
+RYC DP + +D D S A+E VGNL+L+LP+DEDDYLMP+ Q N + M
Sbjct: 1168 NRYCKDPSNKNSSTG-DDETD--SSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNM 1224
Query: 1290 DLISEGCEGQDVNDIRFGEFVSSKRCIDNPEYLMSEESVPPQTLGIPTEPVPXXXXXXXX 1349
+ ++ + + + +DNPEYL++ QTLG+ P+P
Sbjct: 1225 NNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNA-----QTLGVGESPIPTQTIGIPV 1279
Query: 1350 XXXDTTPRPGTSNYMPQRSVEEESMSDHEYYNDLQRELQPLRRNETT 1396
PGT E + SDHEYYND QRELQPL RN T
Sbjct: 1280 MGV-----PGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNT 1321
Score = 87.4 bits (207), Expect = 2e-15
Identities = 73/272 (26%), Positives = 113/272 (41%), Gaps = 41/272 (15%)
Query: 287 CVGTCPK-TCRAEKPIHSGNI-DSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPK 344
C+GT + + + K H N+ D + +CT +DG++E+ T N D SF
Sbjct: 1 CIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLEL-----TWLPNENLDLSF------ 49
Query: 345 MEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQV----VENLFASLYIV 400
+REVTGY+ + H + + F L++I GR + VE +L++
Sbjct: 50 --------LDNIREVTGYILIS--HVDVKKV-VFPKLQIIRGRTLFSLSVEEEKYALFVT 98
Query: 401 KTXXXXXXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKS-KDHKQIIQKNGDPRQCE 459
+ V +G + N NLC+ I W+++V + D R+C
Sbjct: 99 YSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECP 158
Query: 460 KNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSEC 519
K C C+ GCWG GP C C C+ Y + C CH C
Sbjct: 159 K----CHESCT-HGCWGEGPKNCQKFSKLT----CSPQCA-GGRCYGPKPREC--CHLFC 206
Query: 520 LDGCTGASRANCTSCKHVRDGPYCVAQCPESR 551
GCTG ++ +C +CK+ D C +CP R
Sbjct: 207 AGGCTGPTQKDCIACKNFFDEGVCKEECPPMR 238
Score = 49.6 bits (113), Expect = 6e-04
Identities = 31/104 (29%), Positives = 44/104 (42%), Gaps = 16/104 (15%)
Query: 465 CDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCT 524
C P C +G C C +Y E C C + + C QCH EC +GCT
Sbjct: 639 CHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADH-YTDEEQRECFQCHPEC-NGCT 696
Query: 525 GASRANCTSCKHVR------DGPY-------CVAQCP-ESRYAS 554
G +C SC++ + GPY C ++CP E R+ +
Sbjct: 697 GPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVN 740
Score = 45.6 bits (103), Expect = 0.010
Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 8/65 (12%)
Query: 474 CWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCTGASR----A 529
C G G D C C + G+ C+ C P D C++CH+ C DGCTG
Sbjct: 529 CNGAGADHCQECVHVRDGQHCVSEC---PKNKYNDRGVCRECHATC-DGCTGPKDTIGIG 584
Query: 530 NCTSC 534
CT+C
Sbjct: 585 ACTTC 589
Score = 42.7 bits (96), Expect = 0.068
Identities = 28/75 (37%), Positives = 30/75 (40%), Gaps = 10/75 (13%)
Query: 629 CRKCHPLCIK-CVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECKG 687
C KCH C C G G C F + C +C R C CH C G
Sbjct: 157 CPKCHESCTHGCWGEGPKN-----CQKFSKLT-CSPQCAGGRCYGPKPREC--CHLFCAG 208
Query: 688 -CTGPGPTDCIKCKN 701
CTGP DCI CKN
Sbjct: 209 GCTGPTQKDCIACKN 223
>UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;
Drosophila melanogaster|Rep: Epidermal growth factor
receptor - Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 722 bits (1786), Expect = 0.0
Identities = 311/627 (49%), Positives = 404/627 (64%), Gaps = 11/627 (1%)
Query: 105 DVLQGSVGIYSNFNLCHVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGE 164
DVL G VG ++N+NLCH++TI W EI + T + + + + GE
Sbjct: 112 DVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHGCWGE 171
Query: 165 SIENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCS 224
+NCQKFSK CSPQCA GRC+GP PR+CC+ FCAGGCTGP C+AC+NF+DEG C
Sbjct: 172 GPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCK 231
Query: 225 QECPSMQIYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAVNGEC 284
+ECP M+ YNPTTY E NP GKYAYGATCV+ CP HLL+DNGACVRSCP + GEC
Sbjct: 232 EECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDXMDKGGEC 291
Query: 285 IPCVGTCPKTCRAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPK 344
+PC G CPKTC +H+GNIDSF++CT+IDG+I IL+ TF+GFQ V +Y+ G RY
Sbjct: 292 VPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVXANYTMGPRYIP 351
Query: 345 MEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXX 404
++P+ LEVFSTV+E+TGYLN++ HP F +LSYFRNLE I GRQ++E++FA+L IVK+
Sbjct: 352 LDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSL 411
Query: 405 XXXXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNLV 464
++SG++ I NR+LCY I W + K + K + +N CEKN +
Sbjct: 412 YSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTI 471
Query: 465 CDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCT 524
C QC+ DGCWG G DQCL+C+N+NF CI +C YK D+++CK CH EC C
Sbjct: 472 CSDQCNEDGCWGAGTDQCLNCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRT-CN 530
Query: 525 GASRANCTSCKHVRDGPYCVAQCPESRYASEXXXXXXXXXXXXXXXXXXANTVGEGGCNS 584
GA +C C HVRDG +CV++CP+++Y +T+G G C +
Sbjct: 531 GAGADHCQECVHVRDGQHCVSECPKNKY--NDRGVCRECHATCDGCTGPKDTIGIGACTT 588
Query: 585 CNKAIISVEATVESCLKEDEPCPDGYYNEWV-----GNVKPLEGKVKIACRKCHPLCIKC 639
CN AII+ +ATV+ CL +D+ CPDGY+ E+V G++KPL G+ CRKCHPLC C
Sbjct: 589 CNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRA--VCRKCHPLCELC 646
Query: 640 VGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECKGCTGPGPTDCIKC 699
+G HEQVC C +KR +QCE ECP+DH+TDE R C CH EC GCTGPG DC C
Sbjct: 647 TNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSC 706
Query: 700 KNLKIFLGGSDASDENAP-FNCTDTCP 725
+N K+F N+ FNCT CP
Sbjct: 707 RNFKLFDANETGPYVNSTMFNCTSKCP 733
Score = 448 bits (1103), Expect = e-124
Identities = 202/276 (73%), Positives = 243/276 (88%)
Query: 869 ETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEK 928
++TGA +S+EFL EAYIMASVEH NLL+LLAVCM++QMMLITQLMPLGCL+DYVR +++K
Sbjct: 874 KSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDK 933
Query: 929 IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE 988
IGSKA LNW TQIA+GM+YLEEKRLVHRDLAARNVLVQTP+ VKITDFGLAKLL + +E
Sbjct: 934 IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE 993
Query: 989 YKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE 1048
YKAAGGKMPIKWLALECI++R+FT KSDVWAFGVTIWE+L++G RP+ENI A+++P+LIE
Sbjct: 994 YKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIE 1053
Query: 1049 NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMR 1108
GLKL QP IC+LDIYC ++SCW LDA RPTFKQL FAE ARDPGRYL IPGDKF R
Sbjct: 1054 VGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTR 1113
Query: 1109 LPSYSTQDEKEMIRNLSSAMEGPESLVDADEYLQPK 1144
LP+Y++QDEK++IR L+ +G E++ + D+YLQPK
Sbjct: 1114 LPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPK 1149
Score = 101 bits (241), Expect = 2e-19
Identities = 62/167 (37%), Positives = 83/167 (49%), Gaps = 13/167 (7%)
Query: 1230 SRYCSDPMKTRTEVSLEDNFDGMSKAKEAQVGNLKLNLPLDEDDYLMPSPQHTQNASTYM 1289
+RYC DP + +D D S A+E VGNL+L+LP+DEDDYLMP+ Q N + M
Sbjct: 1168 NRYCKDPSNKNSSTG-DDETD--SSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNM 1224
Query: 1290 DLISEGCEGQDVNDIRFGEFVSSKRCIDNPEYLMSEESVPPQTLGIPTEPVPXXXXXXXX 1349
+ ++ + + + +DNPEYL++ QTLG+ P+P
Sbjct: 1225 NNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNA-----QTLGVGESPIPTQTIGIPV 1279
Query: 1350 XXXDTTPRPGTSNYMPQRSVEEESMSDHEYYNDLQRELQPLRRNETT 1396
PGT E + SDHEYYND QRELQPL RN T
Sbjct: 1280 MGV-----PGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNT 1321
Score = 72.1 bits (169), Expect = 1e-10
Identities = 84/309 (27%), Positives = 123/309 (39%), Gaps = 73/309 (23%)
Query: 10 HYRNLRDRFTNCTYVDGNLELT-------------------WLENESMDLSFLKYIREVT 50
H N+ D F NCT +DGN+ + ++ + L ++E+T
Sbjct: 309 HAGNI-DSFRNCTVIDGNIRILDQTFSGFQDVXANYTMGPRYIPLDPERLEVFSTVKEIT 367
Query: 51 GYVLI--SHVKVHKI-VLPQLQIIRGRTLFKLNVREEEFALL-VTMSTAFTLELPALRDV 106
GY+ I +H + + L+ I GR L E FA L + S+ ++LE+ L+ +
Sbjct: 368 GYLNIEGTHPQFRNLSYFRNLETIHGRQLM-----ESMFAALAIVKSSLYSLEMRNLKQI 422
Query: 107 LQGSVGIYSNFNLCHVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESI 166
GSV I N +LC+V I W I ++ Q + N R
Sbjct: 423 SSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWV-------NENLRA------------- 462
Query: 167 ENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQE 226
+ C+K + TICS QC + C+G AG QCL C+NF GTC +
Sbjct: 463 DLCEK-NGTICSDQCNEDGCWG-----------AG------TDQCLNCKNFNFNGTCIAD 504
Query: 227 C----PSMQIYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAVNG 282
C + + N T P GA + C ++D CV CP NK G
Sbjct: 505 CGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVH--VRDGQHCVSECPKNKYNDRG 562
Query: 283 ECIPCVGTC 291
C C TC
Sbjct: 563 VCRECHATC 571
>UniRef50_Q6SAW1 Cluster: Epidermal growth factor receptor; n=70;
Drosophila melanogaster|Rep: Epidermal growth factor
receptor - Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 666 bits (1646), Expect = 0.0
Identities = 317/542 (58%), Positives = 390/542 (71%), Gaps = 18/542 (3%)
Query: 515 CHSECLDGCTGASRANCTSCKHVRDGPYCVAQCPESRYASEXXXXXXXXXXXXXXXXXXA 574
CH EC C GA +C C HVRDG +CV++CP+++Y
Sbjct: 522 CHPECRT-CNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPK-- 578
Query: 575 NTVGEGGCNSCNKAIISVEATVESCLKEDEPCPDGYYNEWV-----GNVKPLEGKVKIAC 629
+T+G G C +CN AII+ +ATV+ CL +D+ CPDGY+ E+V G++KPL G+ C
Sbjct: 579 DTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRA--VC 636
Query: 630 RKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECKGCT 689
RKCHPLC C +G HEQVC C +KR +QCE ECP+DH+TDE R C CH EC GCT
Sbjct: 637 RKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCT 696
Query: 690 GPGPTDCIKCKNLKIFLGGSDASDENAP-FNCTDTCPDNIPNKIYFDEQLQDPIEEPYCS 748
GPG DC C+N K+F N+ FNCT CP + + Y Q PYC+
Sbjct: 697 GPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNY-----QYTAIGPYCA 751
Query: 749 EHANDIPTATARTSTVLVIILVIASLF--LAVLAIIGYNFRQKAKAKKEAVKMTMVLTGC 806
TA ++ I+ A L + +L ++ Y RQK KAKKE VKMTM L+GC
Sbjct: 752 ASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGC 811
Query: 807 EDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKV 866
ED+EPLRP+N+ NL KLRIVK+AELR+GG+LG GAFG+VYKGVWVPEGENVKIPVAIK
Sbjct: 812 EDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKE 871
Query: 867 LKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHK 926
L ++TGA +S+EFL EAYIMASVEH NLL+LLAVCM++QMMLITQLMPLGCL+DYVR ++
Sbjct: 872 LLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNR 931
Query: 927 EKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINE 986
+KIGSKA LNW TQIA+GM+YLEEKRLVHRDLAARNVLVQTP+ VKITDFGLAKLL +
Sbjct: 932 DKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDS 991
Query: 987 DEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPEL 1046
+EYKAAGGKMPIKWLALECI++R+FT KSDVWAFGVTIWE+L++G RP+ENI A+++P+L
Sbjct: 992 NEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDL 1051
Query: 1047 IE 1048
IE
Sbjct: 1052 IE 1053
Score = 139 bits (336), Expect = 6e-31
Identities = 62/79 (78%), Positives = 71/79 (89%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+SVPSN++ HYRNLRDR+TNCTYVDGNLELTWL NE++DLSFL IREVTGY+LISHV V
Sbjct: 8 LSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISHVDV 67
Query: 61 HKIVLPQLQIIRGRTLFKL 79
K+V P+LQIIRGRTLF L
Sbjct: 68 KKVVFPKLQIIRGRTLFSL 86
Score = 103 bits (248), Expect = 3e-20
Identities = 46/95 (48%), Positives = 66/95 (69%)
Query: 332 VNQDYSFGERYPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVE 391
V +Y+ G RY ++P+ LEVFSTV+E+TGYLN++ HP F +LSYFRNLE I GRQ++E
Sbjct: 339 VYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLME 398
Query: 392 NLFASLYIVKTXXXXXXXXXXXXVNSGAIAIMENR 426
++FA+L IVK+ ++SG++ I NR
Sbjct: 399 SMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNR 433
Score = 99.5 bits (237), Expect = 6e-19
Identities = 61/167 (36%), Positives = 83/167 (49%), Gaps = 13/167 (7%)
Query: 1230 SRYCSDPMKTRTEVSLEDNFDGMSKAKEAQVGNLKLNLPLDEDDYLMPSPQHTQNASTYM 1289
+RYC DP + +D D S A+E VGNL+L+LP+DEDDYLMP+ Q N + +
Sbjct: 1168 NRYCKDPSNKNSSTG-DDETD--SSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNI 1224
Query: 1290 DLISEGCEGQDVNDIRFGEFVSSKRCIDNPEYLMSEESVPPQTLGIPTEPVPXXXXXXXX 1349
+ ++ + + + +DNPEYL++ QTLG+ P+P
Sbjct: 1225 NNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNA-----QTLGVGESPIPTQTIGIPV 1279
Query: 1350 XXXDTTPRPGTSNYMPQRSVEEESMSDHEYYNDLQRELQPLRRNETT 1396
PGT E + SDHEYYND QRELQPL RN T
Sbjct: 1280 MGV-----PGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNT 1321
Score = 51.6 bits (118), Expect = 1e-04
Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 10/75 (13%)
Query: 464 VCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGC 523
+C P+C C G G D C C + G+ C+ C P D C++CH+ C DGC
Sbjct: 521 ICHPECRT--CNGAGADHCQECVHVRDGQHCVSEC---PKNKYNDRGVCRECHATC-DGC 574
Query: 524 TGASR----ANCTSC 534
TG CT+C
Sbjct: 575 TGPKDTIGIGACTTC 589
Score = 49.6 bits (113), Expect = 6e-04
Identities = 31/104 (29%), Positives = 44/104 (42%), Gaps = 16/104 (15%)
Query: 465 CDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCT 524
C P C +G C C +Y E C C + + C QCH EC +GCT
Sbjct: 639 CHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPA-DHYTDEEQRECFQCHPEC-NGCT 696
Query: 525 GASRANCTSCKHVR------DGPY-------CVAQCP-ESRYAS 554
G +C SC++ + GPY C ++CP E R+ +
Sbjct: 697 GPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVN 740
>UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23
precursor; n=3; Caenorhabditis|Rep: Receptor
tyrosine-protein kinase let-23 precursor - Caenorhabditis
elegans
Length = 1323
Score = 533 bits (1315), Expect = e-149
Identities = 387/1315 (29%), Positives = 620/1315 (47%), Gaps = 147/1315 (11%)
Query: 13 NLRDRFTNCTYVDGNLELTWLE-----------NESMD----------LSFLKYIREVTG 51
+L + C V GNLE+TW+E N ++D ++F + E+ G
Sbjct: 58 DLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRG 117
Query: 52 YVLISHVKVHKIVLPQLQIIRGRTLFKLNVREEEFALLVTMST-AFTLELPALRDVLQGS 110
++I + KI P+L++I G +F N AL + + + + LR + GS
Sbjct: 118 SLIIYRANIQKISFPRLRVIYGDEVFHDN------ALYIHKNDKVHEVVMRELRVIRNGS 171
Query: 111 VGIYSNFNLCHV-KTINWDEI--NQDLTQVTFTFI---ILPLGKGNARV--VTQPARWAA 162
V I N +C++ I+W E+ + D+ +V T GK A+ W +
Sbjct: 172 VTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCNDKCWGS 231
Query: 163 GESIENCQKFSKTICSPQCAQGRCFGPNPR---DCCNTFCAGGCTGPLPTQCLACRNFYD 219
G++ +CQ+ +++C C+Q CF N +CC++ C GGCTG P C+AC +
Sbjct: 232 GDN--DCQRVYRSVCPKSCSQ--CFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYEL 287
Query: 220 EGTCSQECPSMQIYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPP---- 275
+G C + CPS +I+N T NP+G+Y G CV+ CP LL +N CVR C
Sbjct: 288 DGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHY 347
Query: 276 NKTAVNGECIPC-VGTCPKTCRAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQ 334
+ T EC C +CPK C + + + + + + C IDG + I+E FT ++Q
Sbjct: 348 DATKDVRECEKCRSSSCPKICTVDGHLTNETLKNLEGCEQIDGHL-IIEHAFT-YEQ--- 402
Query: 335 DYSFGERYPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLF 394
L+V TV+ V+ Y+ + NF L + +NL++I GR++ +
Sbjct: 403 ---------------LKVLETVKIVSEYITIV--QQNFYDLKFLKNLQIIEGRKLHNVRW 445
Query: 395 ASLYIVKTXXXXXXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLV--KSKDHKQ--IIQ 450
A + +GA+ IM+N LCY KI W+ ++ K KD+K I
Sbjct: 446 ALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIA 505
Query: 451 KNGDPRQCEKNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHK 510
+N D + CE VCD C+ GCWG P+ CL C+ + C++ C L
Sbjct: 506 ENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQTSM 565
Query: 511 SCKQCHSECLDGCTGASRANCTSCKH--VRDGPY-----CVAQCPESRYASEXXXXXXXX 563
C++C EC + C G +C +C+H + + + CV CP S + ++
Sbjct: 566 KCERCSPEC-ETCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCH 624
Query: 564 XXXXXXXXXXANT-VGEGGCNSCNKAIISVEATVESCLKE---DEPCPDGYYNEWVGNVK 619
++ +G GGC C A+ T+ CL+ + C + + +
Sbjct: 625 PTCYDNGCTGPDSNLGYGGCKQCKYAVKYENDTI-FCLQSSGMNNVCVENDLPNYYISTY 683
Query: 620 PLEGKVKIACRKCHPLCIKC--VGFGIHEQVCQVCNGFKRGDQ-----CEDECPSDHF-- 670
EG ++ C KC C C G + + C VC + C D+CP + F
Sbjct: 684 DTEGVIETHCEKCSISCKTCSSAGRNVVQNKC-VCKHVEYQPNPSERICMDQCPVNSFMV 742
Query: 671 TDEIGRNCTPCHSECK---GCTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDN 727
D C CH EC C T C KCKN +F G D + C CP N
Sbjct: 743 PDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKG--DIA------QCVSECPKN 794
Query: 728 IPNKIYFDEQLQDPIEEPYCSEHANDIPTATARTSTVLV--IILVIASLFLAVLAIIGYN 785
+P +P C ++ DI + +T V++ ++ A +FL +L ++ +
Sbjct: 795 LP--------FSNPANGE-CLDY--DIASRQRKTRMVIIGSVLFGFAVMFLFIL-LVYWR 842
Query: 786 FRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAEL--RRGGMLGFGAF 843
++ K K A + M + P+ +V+PN++++ ++ +EL + LG GAF
Sbjct: 843 CQRIGKKLKIAEMVDM-----PELTPI-DASVRPNMSRICLIPSSELQTKLDKKLGAGAF 896
Query: 844 GKVYKGVWVPE-GENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCM 902
G V+ G++ P+ +NVKIPVAIKV + T + + E LEEA M + H NLL+++ CM
Sbjct: 897 GTVFAGIYYPKRAKNVKIPVAIKVFQ--TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCM 954
Query: 903 TNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAAR 961
+ + ++T PLG L ++++ HKE +G++ + +C QIA GM YLE++R+VHRDLA R
Sbjct: 955 HDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATR 1014
Query: 962 NVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFG 1021
NVLV+ N V+ITDFGL+K+L + D GK+ IKWLA+E +TH SDVWAFG
Sbjct: 1015 NVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFG 1074
Query: 1022 VTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTF 1081
VT WEI+++G PY+ +S ++ +++G +L QP C+ D+Y ++ CWM D SRP F
Sbjct: 1075 VTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGF 1134
Query: 1082 KQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDADEYL 1141
+ L + F E + P +L S + + E IR + P+ D
Sbjct: 1135 EILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSL- 1193
Query: 1142 QPKFKSMTGTVTTNSALSAGMETQTSSLKPCTSSSWPNNAGQDGVPDPS---TKPENWDH 1198
P S ++ T + + + S+ + P + G D S K +
Sbjct: 1194 -PSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQ 1252
Query: 1199 EMLRYNNQLNPDG-SEVR----HYYNNGVCASDTSSSRYCSDP-MKTRTEVSLED 1247
+ Y N DG +E+ YYN + +SSS Y ++P +KT+ + E+
Sbjct: 1253 SAVLYTAVTNEDGQTELSPSNGDYYNQP--NTPSSSSGYYNEPHLKTKKPETSEE 1305
>UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase
erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine
kinase-type cell surface receptor HER4).; n=1; Takifugu
rubripes|Rep: Receptor tyrosine-protein kinase erbB-4
precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type
cell surface receptor HER4). - Takifugu rubripes
Length = 1236
Score = 498 bits (1229), Expect = e-139
Identities = 257/524 (49%), Positives = 336/524 (64%), Gaps = 38/524 (7%)
Query: 632 CHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECP--SDHFTDEIGRN-CTPCHSECK-- 686
C PLC +G C C F RG C D C + + C C +C+
Sbjct: 480 CDPLCSGAGCWGPGPDQCLSCKYFSRGRTCVDGCNLYEGEIREYANESVCVECDGQCELA 539
Query: 687 -----GCTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDNIPNKIYFDEQLQDP 741
C GPGP C KC + K + P NC + CPD + F + +
Sbjct: 540 DDDSLTCHGPGPEHCEKCLHFK-----------DGP-NCVEKCPDGLQGANSFIFKYAEA 587
Query: 742 IEEPYCSEHANDIPTATARTSTVLVIILVIASLFLAVLAI--IGYNFRQKAKAKKEAVKM 799
E + HAN T L+ VI LF+ V+ + + + R+K KK A++
Sbjct: 588 NNECHPC-HAN------CTQGTPLIAAGVIGVLFMVVILVLSVAVSVRRKNIKKKRALRR 640
Query: 800 TMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVK 859
+ E EPL P+ PN A+LRI+KE EL+R +LG GAFG VYKG+WVPEGE VK
Sbjct: 641 FLET---ELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGEKVK 697
Query: 860 IPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLV 919
IPVA+K+L E TG + EF++EA IMAS+EHP+L++LL VC++ + L+TQLMP GCL+
Sbjct: 698 IPVAVKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQLVTQLMPHGCLL 757
Query: 920 DYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLA 979
DYV HK+ IGS+ LNWC QIA+GM YLEE+RLVHRDLAARNVLV++PN +KITDFGLA
Sbjct: 758 DYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLA 817
Query: 980 KLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENIS 1039
+LLD+NE EY A GGKM IKW+ALECI +R FTH+SDVW++GVTIWE++++G +PY+ IS
Sbjct: 818 RLLDVNEKEYNADGGKMAIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIS 877
Query: 1040 ARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYL 1099
R++P+L+E G +LPQP ICT+D+Y VMV CWM+DADSRP FK+LA F MARDP RYL
Sbjct: 878 TRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFTRMARDPQRYL 937
Query: 1100 VIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDADEYLQP 1143
VI GD M+LP ++ + ++L A E E L+DA+EYL P
Sbjct: 938 VIQGDDCMKLPG---PNDSKFFQSL-LAEEELEDLMDAEEYLVP 977
Score = 396 bits (974), Expect = e-108
Identities = 216/586 (36%), Positives = 311/586 (53%), Gaps = 59/586 (10%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+S S+ D Y+ +R + NC V GNLE+T ++ S +L+FL+ IREVTGYVL++ +
Sbjct: 9 LSTLSDLDQQYQTMRKNYENCEVVMGNLEITSIDR-SRNLTFLRSIREVTGYVLVALNQF 67
Query: 61 HKIVLPQLQIIRGRTLFKLNVREEEFALLVTM-------STAFTLELPALRDVLQGSVGI 113
+ L L+IIRG L+ E+ +AL + + S L L L ++L G V +
Sbjct: 68 DYLPLENLRIIRGTKLY-----EDRYALAIFLNYRRDGNSGLRQLGLKNLTEILNGGVYV 122
Query: 114 YSNFNLCHVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAA-----GESIEN 168
N LCH TI+W +I + +++P N+ + Q + G ++
Sbjct: 123 DRNNFLCHADTIHWQDI---VKHPRIHPLVVPT---NSSITCQKCHRSCNGRCWGPKVDQ 176
Query: 169 CQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECP 228
CQ +KT+C+ QC GRCFGP DCC+ CAGGC GP T C AC NF D G C +CP
Sbjct: 177 CQSLTKTVCAEQC-DGRCFGPYISDCCHRECAGGCYGPKDTDCFACTNFNDSGACVTQCP 235
Query: 229 SMQIYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAV--NG--EC 284
YN T+ E N KY YGA CV+ CP + + D+ +CVR+CP NK V NG C
Sbjct: 236 QPFFYNSITFQLEHNVRTKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENGIKIC 295
Query: 285 IPCVGTCPKTC--------RAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDY 336
IPC CPK C + + + S NID F +CT I+G++ L TG + Y
Sbjct: 296 IPCTDICPKACDGIGTASLQTAQTVDSSNIDKFVNCTKINGNLVFL---ITGIK--GDSY 350
Query: 337 SFGERYPKMEPDALEVFSTVREVTG-----YLNVQAHHPNFTSLSYFRNLEVIGGRQVVE 391
++P+ L VF TVRE+TG +LN+Q+ N T LS F NL IGGR +
Sbjct: 351 ---HNIEALDPEKLNVFRTVREITGESHERFLNIQSWPDNMTDLSVFSNLATIGGRTLYS 407
Query: 392 NLFASLYIVKTXXXXXXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQK 451
+ + L + + +++G + + +N LCY + I W +L ++ K +I+
Sbjct: 408 GI-SLLVLKQQGISSLQLQSLREISAGNVHVADNSQLCYYNTINWTRLFRTAHQKALIRN 466
Query: 452 NGDPRQCEKNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYK--ADH 509
N P QC K +VCDP CS GCWGPGPDQCLSC+ ++ G C+D C+++ G + A+
Sbjct: 467 NQSPEQCSKKRMVCDPLCSGAGCWGPGPDQCLSCKYFSRGRTCVDGCNLYEGEIREYANE 526
Query: 510 KSCKQCHSEC--LDG----CTGASRANCTSCKHVRDGPYCVAQCPE 549
C +C +C D C G +C C H +DGP CV +CP+
Sbjct: 527 SVCVECDGQCELADDDSLTCHGPGPEHCEKCLHFKDGPNCVEKCPD 572
Score = 48.0 bits (109), Expect = 0.002
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 11/77 (14%)
Query: 627 IACRKCHPLCI-KCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSEC 685
I C+KCH C +C G + + CQ +QC+ C + +D C CH EC
Sbjct: 156 ITCQKCHRSCNGRCWGPKVDQ--CQSLTKTVCAEQCDGRCFGPYISD-----C--CHREC 206
Query: 686 KG-CTGPGPTDCIKCKN 701
G C GP TDC C N
Sbjct: 207 AGGCYGPKDTDCFACTN 223
>UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4
precursor; n=58; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-4 precursor - Homo sapiens
(Human)
Length = 1308
Score = 497 bits (1227), Expect = e-139
Identities = 267/559 (47%), Positives = 355/559 (63%), Gaps = 55/559 (9%)
Query: 632 CHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECP--SDHFTD-EIGRNCTPCHSECKG- 687
C+ LC +G C C F RG C + C F + E G C C +C+
Sbjct: 503 CNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKM 562
Query: 688 ------CTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDNIPNKIYFDEQLQDP 741
C GPGP +C KC + K + P NC + CPD + F + DP
Sbjct: 563 EDGLLTCHGPGPDNCTKCSHFK-----------DGP-NCVEKCPDGLQGANSFIFKYADP 610
Query: 742 IEE-----PYCSEHANDIPTA--------TARTS------TVLVIILVIASLFLAVLAII 782
E P C++ N PT+ T ++ T L+ VI LF +L I+
Sbjct: 611 DRECHPCHPNCTQGCNG-PTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLF--ILVIV 667
Query: 783 GYNF----RQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGML 838
G F R+K+ KK A++ + E EPL P+ PN A+LRI+KE EL+R +L
Sbjct: 668 GLTFAVYVRRKSIKKKRALRRFLET---ELVEPLTPSGTAPNQAQLRILKETELKRVKVL 724
Query: 839 GFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLL 898
G GAFG VYKG+WVPEGE VKIPVAIK+L ETTG + EF++EA IMAS++HP+L++LL
Sbjct: 725 GSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLL 784
Query: 899 AVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDL 958
VC++ + L+TQLMP GCL++YV HK+ IGS+ LNWC QIA+GM YLEE+RLVHRDL
Sbjct: 785 GVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDL 844
Query: 959 AARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVW 1018
AARNVLV++PN VKITDFGLA+LL+ +E EY A GGKMPIKW+ALECI +R FTH+SDVW
Sbjct: 845 AARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVW 904
Query: 1019 AFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSR 1078
++GVTIWE++++G +PY+ I R +P+L+E G +LPQP ICT+D+Y VMV CWM+DADSR
Sbjct: 905 SYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSR 964
Query: 1079 PTFKQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDAD 1138
P FK+LA F+ MARDP RYLVI GD M+LPS ++ + +NL E E ++DA+
Sbjct: 965 PKFKELAAEFSRMARDPQRYLVIQGDDRMKLPS---PNDSKFFQNLLDE-EDLEDMMDAE 1020
Query: 1139 EYLQPKFKSMTGTVTTNSA 1157
EYL P+ ++ + T+ A
Sbjct: 1021 EYLVPQAFNIPPPIYTSRA 1039
Score = 407 bits (1003), Expect = e-112
Identities = 222/577 (38%), Positives = 317/577 (54%), Gaps = 45/577 (7%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+S S+ + YR LR + NC V GNLE+T +E+ + DLSFL+ +REVTGYVL++ +
Sbjct: 36 LSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEH-NRDLSFLRSVREVTGYVLVALNQF 94
Query: 61 HKIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTA----FTLE---LPALRDVLQGSVGI 113
+ L L+IIRG L+ E+ +AL + ++ F L+ L L ++L G V +
Sbjct: 95 RYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYV 149
Query: 114 YSNFNLCHVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFS 173
N LC+ TI+W +I ++ T + G R G + +CQ +
Sbjct: 150 DQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLT 209
Query: 174 KTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQIY 233
+T+C+ QC GRC+GP DCC+ CAGGC+GP T C AC NF D G C +CP +Y
Sbjct: 210 RTVCAEQC-DGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVY 268
Query: 234 NPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAV--NG--ECIPCVG 289
NPTT+ E N N KY YGA CV+ CP + + D+ +CVR+CP +K V NG C PC
Sbjct: 269 NPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTD 328
Query: 290 TCPKTC--------RAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGER 341
CPK C + + + S NID F +CT I+G++ L TG Y+ E
Sbjct: 329 ICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFL---VTGIH--GDPYNAIE- 382
Query: 342 YPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVK 401
++P+ L VF TVRE+TG+LN+Q+ PN T S F NL IGGR + L SL I+K
Sbjct: 383 --AIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGL--SLLILK 438
Query: 402 -TXXXXXXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEK 460
+++G I I +N NLCY I W L + + + +I+ N C
Sbjct: 439 QQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTA 498
Query: 461 NNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYK--ADHKSCKQCHSE 518
+VC+ CS+DGCWGPGPDQCLSC+ ++ G ICI++C+++ G ++ + C +C +
Sbjct: 499 EGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQ 558
Query: 519 C---LDG---CTGASRANCTSCKHVRDGPYCVAQCPE 549
C DG C G NCT C H +DGP CV +CP+
Sbjct: 559 CEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPD 595
Score = 83.4 bits (197), Expect = 4e-14
Identities = 59/209 (28%), Positives = 94/209 (44%), Gaps = 25/209 (11%)
Query: 350 LEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFA-SLYIVKTXXXXXX 408
L +VREVTGY+ V + + L NL +I G ++ E+ +A ++++
Sbjct: 74 LSFLRSVREVTGYVLVALNQFRYLPLE---NLRIIRGTKLYEDRYALAIFLNYRKDGNFG 130
Query: 409 XXXXXXVN-----SGAIAIMENRNLCYADKIAWNKLVKSK--DHKQIIQKNGDPRQCEKN 461
N +G + + +N+ LCYAD I W +V++ + ++ NG C +
Sbjct: 131 LQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSG-CGR- 188
Query: 462 NLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLD 521
C C+ CWGP + C + E C C G Y +D C CH EC
Sbjct: 189 ---CHKSCTGR-CWGPTENHCQTLTRTVCAEQCDGRCY---GPYVSD---C--CHRECAG 236
Query: 522 GCTGASRANCTSCKHVRDGPYCVAQCPES 550
GC+G +C +C + D CV QCP++
Sbjct: 237 GCSGPKDTDCFACMNFNDSGACVTQCPQT 265
Score = 71.7 bits (168), Expect = 1e-10
Identities = 81/304 (26%), Positives = 127/304 (41%), Gaps = 56/304 (18%)
Query: 16 DRFTNCTYVDGNLE--LTWLEN------ESMD---LSFLKYIREVTGYVLISHVKVHKI- 63
D+F NCT ++GNL +T + E++D L+ + +RE+TG++ I +
Sbjct: 354 DKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTD 413
Query: 64 --VLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFT-LELPALRDVLQGSVGIYSNFNLC 120
V L I GR L+ +LL+ T L+ +L+++ G++ I N NLC
Sbjct: 414 FSVFSNLVTIGGRVLYS------GLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLC 467
Query: 121 HVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKTICSPQ 180
+ TINW + F+ I N R+V + R A ENC +C+
Sbjct: 468 YYHTINWTTL--------FSTI-------NQRIVIRDNRKA-----ENCTA-EGMVCNHL 506
Query: 181 CAQGRCFGPNPRDC--CNTFCAGG-CTGPLPTQCLACRNFYDEGTCSQ---ECPSMQIYN 234
C+ C+GP P C C F G C R F + C + +C M+
Sbjct: 507 CSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGL 566
Query: 235 PTTYSWEPNPNGKYAY---GATCVRNCPEHLLKDNGACVRSCPPNKTAVNGECIPCVGTC 291
T + P+ K ++ G CV CP+ L N + P++ EC PC C
Sbjct: 567 LTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDR-----ECHPCHPNC 621
Query: 292 PKTC 295
+ C
Sbjct: 622 TQGC 625
Score = 60.9 bits (141), Expect = 2e-07
Identities = 32/94 (34%), Positives = 47/94 (50%), Gaps = 14/94 (14%)
Query: 452 NGDPRQCEKNNLV--CDPQCSA--DG---CWGPGPDQCLSCQNYNFGEICIDNC-----S 499
+G+ R+ E ++ CDPQC DG C GPGPD C C ++ G C++ C
Sbjct: 540 DGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQG 599
Query: 500 VHPGLYK-AD-HKSCKQCHSECLDGCTGASRANC 531
+ ++K AD + C CH C GC G + +C
Sbjct: 600 ANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDC 633
Score = 52.8 bits (121), Expect = 6e-05
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 11/92 (11%)
Query: 612 NEWVGNVKPLEGKVKIACRKCHPLCI-KCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHF 670
N W N+ + C +CH C +C +G E CQ +QC+ C +
Sbjct: 169 NPWPSNLTLVSTNGSSGCGRCHKSCTGRC--WGPTENHCQTLTRTVCAEQCDGRCYGPYV 226
Query: 671 TDEIGRNCTPCHSECKG-CTGPGPTDCIKCKN 701
+D C CH EC G C+GP TDC C N
Sbjct: 227 SD-----C--CHRECAGGCSGPKDTDCFACMN 251
Score = 46.0 bits (104), Expect = 0.007
Identities = 27/78 (34%), Positives = 35/78 (44%), Gaps = 11/78 (14%)
Query: 629 CRKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECP-----SDHFTDEIG---RNCTP 680
C K + C G G C C+ FK G C ++CP ++ F + R C P
Sbjct: 559 CEKMEDGLLTCHGPGPDN--CTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHP 616
Query: 681 CHSEC-KGCTGPGPTDCI 697
CH C +GC GP DCI
Sbjct: 617 CHPNCTQGCNGPTSHDCI 634
>UniRef50_P00533 Cluster: Epidermal growth factor receptor precursor;
n=124; root|Rep: Epidermal growth factor receptor
precursor - Homo sapiens (Human)
Length = 1210
Score = 472 bits (1163), Expect = e-131
Identities = 253/572 (44%), Positives = 344/572 (60%), Gaps = 39/572 (6%)
Query: 622 EGKVKIACRKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPS-DHFTDEIGRN--C 678
E K + CH LC +G + C C RG +C D+C + E N C
Sbjct: 496 ENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSEC 555
Query: 679 TPCHSECKG------CTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDNIPNKI 732
CH EC CTG GP +CI+C + ++ G +C TCP + +
Sbjct: 556 IQCHPECLPQAMNITCTGRGPDNCIQCAH---YIDGP---------HCVKTCPAGVMGEN 603
Query: 733 ------YFDEQLQDPIEEPYCSEHAND-----IPTATARTSTVLVIILVIASLFLAVLAI 781
Y D + P C+ PT + ++ ++ L L V
Sbjct: 604 NTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALG 663
Query: 782 IGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFG 841
IG R++ +K ++ +L E EPL P+ PN A LRI+KE E ++ +LG G
Sbjct: 664 IGLFMRRRHIVRKRTLRR--LLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSG 721
Query: 842 AFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVC 901
AFG VYKG+W+PEGE VKIPVAIK L+E T +KE L+EAY+MASV++P++ +LL +C
Sbjct: 722 AFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGIC 781
Query: 902 MTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAAR 961
+T+ + LITQLMP GCL+DYVR HK+ IGS+ LNWC QIA+GM YLE++RLVHRDLAAR
Sbjct: 782 LTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAAR 841
Query: 962 NVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFG 1021
NVLV+TP VKITDFGLAKLL E EY A GGK+PIKW+ALE I HRI+TH+SDVW++G
Sbjct: 842 NVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYG 901
Query: 1022 VTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTF 1081
VT+WE++++G++PY+ I A + ++E G +LPQP ICT+D+Y +MV CWM+DADSRP F
Sbjct: 902 VTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKF 961
Query: 1082 KQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDADEYL 1141
++L F++MARDP RYLVI GD+ M LPS + R L E + +VDADEYL
Sbjct: 962 RELIIEFSKMARDPQRYLVIQGDERMHLPS---PTDSNFYRALMDE-EDMDDVVDADEYL 1017
Query: 1142 QPKFKSMTGTVTTNSALSAGME-TQTSSLKPC 1172
P+ + T+ + L + + T +S C
Sbjct: 1018 IPQQGFFSSPSTSRTPLLSSLSATSNNSTVAC 1049
Score = 397 bits (978), Expect = e-109
Identities = 221/567 (38%), Positives = 307/567 (54%), Gaps = 41/567 (7%)
Query: 8 DTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKVHKIVLPQ 67
+ H+ +L+ F NC V GNLE+T+++ + DLSFLK I+EV GYVLI+ V +I L
Sbjct: 45 EDHFLSLQRMFNNCEVVLGNLEITYVQR-NYDLSFLKTIQEVAGYVLIALNTVERIPLEN 103
Query: 68 LQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPA--LRDVLQGSVGIYSNFNLCHVKTI 125
LQIIRG ++ + + T ELP L+++L G+V +N LC+V++I
Sbjct: 104 LQIIRGNMYYENSYALAVLSNYDANKTGLK-ELPMRNLQEILHGAVRFSNNPALCNVESI 162
Query: 126 NW-DEINQD-LTQVTFTFIILPLGKGNARVVTQP--ARWAAGESIENCQKFSKTICSPQC 181
W D ++ D L+ ++ F LG + P + W AGE ENCQK +K IC+ QC
Sbjct: 163 QWRDIVSSDFLSNMSMDFQN-HLGSCQKCDPSCPNGSCWGAGE--ENCQKLTKIICAQQC 219
Query: 182 AQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQIYNPTTYSWE 241
+ GRC G +P DCC+ CA GCTGP + CL CR F DE TC CP + +YNPTTY +
Sbjct: 220 S-GRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMD 278
Query: 242 PNPNGKYAYGATCVRNCP-EHLLKDNGACVRSCPPNKTAVNGE----CIPCVGTCPKTC- 295
NP GKY++GATCV+ CP +++ D+G+CVR+C + + + C C G C K C
Sbjct: 279 VNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCN 338
Query: 296 -------RAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPD 348
+ I++ NI FK+CT I G + IL + F G SF P ++P
Sbjct: 339 GIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRG-------DSF-THTPPLDPQ 390
Query: 349 ALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXXXXX 408
L++ TV+E+TG+L +QA N T L F NLE+I GR F SL +V
Sbjct: 391 ELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQF-SLAVVSLNITSLG 449
Query: 409 XXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNLVCDPQ 468
++ G + I N+NLCYA+ I W KL + K I N C+ VC
Sbjct: 450 LRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHAL 509
Query: 469 CSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYK--ADHKSCKQCHSECLD----- 521
CS +GCWGP P C+SC+N + G C+D C++ G + ++ C QCH ECL
Sbjct: 510 CSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNI 569
Query: 522 GCTGASRANCTSCKHVRDGPYCVAQCP 548
CTG NC C H DGP+CV CP
Sbjct: 570 TCTGRGPDNCIQCAHYIDGPHCVKTCP 596
Score = 71.3 bits (167), Expect = 2e-10
Identities = 74/275 (26%), Positives = 113/275 (41%), Gaps = 48/275 (17%)
Query: 18 FTNCTYVDGNLEL--------TWLENESMD---LSFLKYIREVTGYVLISHVKVHKIVL- 65
F NCT + G+L + ++ +D L LK ++E+TG++LI ++ L
Sbjct: 359 FKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLH 418
Query: 66 --PQLQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSVGIYSNFNLCHVK 123
L+IIRGRT + +F+L V +L L +L+++ G V I N NLC+
Sbjct: 419 AFENLEIIRGRTK-----QHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYAN 473
Query: 124 TINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKTICSPQCAQ 183
TINW ++ Q T ++++ EN K + +C C+
Sbjct: 474 TINWKKLFGTSGQKT-------------KIISNRG--------ENSCKATGQVCHALCSP 512
Query: 184 GRCFGPNPRDC--CNTFCAGG-CTGPLPTQCLACRNFYDEGTCSQECPSM--QIYNPTTY 238
C+GP PRDC C G C R F + C Q P Q N T
Sbjct: 513 EGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCT 572
Query: 239 SWEPN---PNGKYAYGATCVRNCPEHLLKDNGACV 270
P+ Y G CV+ CP ++ +N V
Sbjct: 573 GRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLV 607
Score = 50.4 bits (115), Expect = 3e-04
Identities = 30/94 (31%), Positives = 42/94 (44%), Gaps = 16/94 (17%)
Query: 453 GDPRQCEKNN--LVCDPQCSADG----CWGPGPDQCLSCQNYNFGEICIDNCSV------ 500
G+PR+ +N+ + C P+C C G GPD C+ C +Y G C+ C
Sbjct: 544 GEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGEN 603
Query: 501 HPGLYK---ADHKSCKQCHSECLDGCTGASRANC 531
+ ++K A H C CH C GCTG C
Sbjct: 604 NTLVWKYADAGHV-CHLCHPNCTYGCTGPGLEGC 636
Score = 50.0 bits (114), Expect = 5e-04
Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 20/99 (20%)
Query: 628 ACRKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSEC-K 686
+C+KC P C +G E+ CQ QC C +D C CH++C
Sbjct: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSD-----C--CHNQCAA 238
Query: 687 GCTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCP 725
GCTGP +DC+ C+ + DE C DTCP
Sbjct: 239 GCTGPRESDCLVCRKFR---------DE---ATCKDTCP 265
Score = 39.5 bits (88), Expect = 0.64
Identities = 29/94 (30%), Positives = 35/94 (37%), Gaps = 18/94 (19%)
Query: 619 KPLEGKVKIACRKCHPLC------IKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTD 672
+P E C +CHP C I C G G C C + G C CP+ +
Sbjct: 545 EPREFVENSECIQCHPECLPQAMNITCTGRGPDN--CIQCAHYIDGPHCVKTCPAGVMGE 602
Query: 673 ---------EIGRNCTPCHSECK-GCTGPGPTDC 696
+ G C CH C GCTGPG C
Sbjct: 603 NNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGC 636
>UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2
precursor; n=36; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-2 precursor - Homo sapiens
(Human)
Length = 1255
Score = 458 bits (1130), Expect = e-127
Identities = 235/537 (43%), Positives = 332/537 (61%), Gaps = 44/537 (8%)
Query: 632 CHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDEC------PSDHFTDEIGRNCTPCHSEC 685
CH LC + +G C C+ F RG +C +EC P ++ R+C PCH EC
Sbjct: 511 CHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVN---ARHCLPCHPEC 567
Query: 686 KG------CTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDNIPNKIYFDEQLQ 739
+ C GP C+ C + K + PF C CP + + + +
Sbjct: 568 QPQNGSVTCFGPEADQCVACAHYK-----------DPPF-CVARCPSGVKPDLSYMPIWK 615
Query: 740 DPIEE------PY-CSEHANDIPT----ATARTSTVLVIILVIASLFLAVLAIIGYNFRQ 788
P EE P C+ D+ A R S + II + + L V+ + +
Sbjct: 616 FPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILI 675
Query: 789 KAKAKK-EAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVY 847
K + +K M +L E EPL P+ PN A++RI+KE ELR+ +LG GAFG VY
Sbjct: 676 KRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY 735
Query: 848 KGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMM 907
KG+W+P+GENVKIPVAIKVL+E T +KE L+EAY+MA V P + +LL +C+T+ +
Sbjct: 736 KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQ 795
Query: 908 LITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQT 967
L+TQLMP GCL+D+VR ++ ++GS+ LNWC QIA+GM+YLE+ RLVHRDLAARNVLV++
Sbjct: 796 LVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKS 855
Query: 968 PNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEI 1027
PN VKITDFGLA+LLDI+E EY A GGK+PIKW+ALE I R FTH+SDVW++GVT+WE+
Sbjct: 856 PNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL 915
Query: 1028 LSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADT 1087
+++GA+PY+ I AR +P+L+E G +LPQP ICT+D+Y +MV CWM+D++ RP F++L
Sbjct: 916 MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSE 975
Query: 1088 FAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDADEYLQPK 1144
F+ MARDP R++VI + + + ++ + + LVDA+EYL P+
Sbjct: 976 FSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLED-----DDMGDLVDAEEYLVPQ 1027
Score = 337 bits (829), Expect = 1e-90
Identities = 200/583 (34%), Positives = 291/583 (49%), Gaps = 49/583 (8%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+ +P++ +TH LR + C V GNLELT+L + LSFL+ I+EV GYVLI+H +V
Sbjct: 33 LRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNA-SLSFLQDIQEVQGYVLIAHNQV 91
Query: 61 HKIVLPQLQIIRGRTLFKLN----VREEEFALLVTMSTAFT-------LELPALRDVLQG 109
++ L +L+I+RG LF+ N V + L T L+L +L ++L+G
Sbjct: 92 RQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKG 151
Query: 110 SVGIYSNFNLCHVKTINWDEINQDLTQVTFTFIILPLGKG--NARVVTQPAR-WAAGESI 166
V I N LC+ TI W +I Q+ T I + + + +R W GES
Sbjct: 152 GVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCW--GESS 209
Query: 167 ENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQE 226
E+CQ ++T+C+ CA RC GP P DCC+ CA GCTGP + CLAC +F G C
Sbjct: 210 EDCQSLTRTVCAGGCA--RCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELH 267
Query: 227 CPSMQIYNPTTYSWEPNPNGKYAYGATCVRNCP-EHLLKDNGACVRSCPPNKTAVNGE-- 283
CP++ YN T+ PNP G+Y +GA+CV CP +L D G+C CP + V E
Sbjct: 268 CPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDG 327
Query: 284 ---CIPCVGTCPKTC--------RAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQV 332
C C C + C R + + S NI F C I GS+ L +F G
Sbjct: 328 TQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPAS 387
Query: 333 NQDYSFGERYPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVEN 392
N ++P+ L+VF T+ E+TGYL + A + LS F+NL+VI GR ++ N
Sbjct: 388 NT--------APLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGR-ILHN 438
Query: 393 LFASLYIVKTXXXXXXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKN 452
SL + + SG I N +LC+ + W++L ++ + N
Sbjct: 439 GAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTAN 498
Query: 453 GDPRQCEKNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYK--ADHK 510
+C L C C+ CWGPGP QC++C + G+ C++ C V GL + + +
Sbjct: 499 RPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNAR 558
Query: 511 SCKQCHSEC--LDG---CTGASRANCTSCKHVRDGPYCVAQCP 548
C CH EC +G C G C +C H +D P+CVA+CP
Sbjct: 559 HCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCP 601
Score = 56.8 bits (131), Expect = 4e-06
Identities = 62/212 (29%), Positives = 94/212 (44%), Gaps = 28/212 (13%)
Query: 40 LSFLKYIREVTGYVLIS---HVKVHKIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTAF 96
L + + E+TGY+ IS V LQ+IRGR L ++L +
Sbjct: 397 LQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRIL-----HNGAYSLTLQGLGIS 451
Query: 97 TLELPALRDVLQGSVGIYSNFNLCHVKTINWDEINQDLTQVTFTFIILP----LGKGNA- 151
L L +LR++ G I+ N +LC V T+ WD++ ++ Q P +G+G A
Sbjct: 452 WLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLAC 511
Query: 152 -RVVTQPARWAAGES-IENCQKFSK-TICSPQCA--QG--RCFGPNPRDC--CNTFCA-- 200
++ + W G + NC +F + C +C QG R + N R C C+ C
Sbjct: 512 HQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREY-VNARHCLPCHPECQPQ 570
Query: 201 -GG--CTGPLPTQCLACRNFYDEGTCSQECPS 229
G C GP QC+AC ++ D C CPS
Sbjct: 571 NGSVTCFGPEADQCVACAHYKDPPFCVARCPS 602
Score = 38.3 bits (85), Expect = 1.5
Identities = 22/71 (30%), Positives = 29/71 (40%), Gaps = 6/71 (8%)
Query: 630 RKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECK-GC 688
R CHP C G + + C R C C + +C CH +C GC
Sbjct: 190 RACHPCSPMCKGSRCWGESSEDCQSLTR-TVCAGGCA--RCKGPLPTDC--CHEQCAAGC 244
Query: 689 TGPGPTDCIKC 699
TGP +DC+ C
Sbjct: 245 TGPKHSDCLAC 255
>UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming protein
erbB; n=8; root|Rep: Tyrosine-protein kinase transforming
protein erbB - Avian leukosis virus (ALV)
Length = 634
Score = 447 bits (1101), Expect = e-123
Identities = 214/401 (53%), Positives = 285/401 (71%), Gaps = 8/401 (1%)
Query: 774 LFLAVLAI-IGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAEL 832
L L V+ + IG R++ +K ++ +L E EPL P+ PN A LRI+KE E
Sbjct: 75 LCLVVVGLGIGLYLRRRHIVRKRTLRR--LLQERELVEPLTPSGEAPNQAHLRILKETEF 132
Query: 833 RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHP 892
++ +LG GAFG VYKG+W+PEGE VKIPVAIK L+E T +KE L+EAY+MASV++P
Sbjct: 133 KKVKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNP 192
Query: 893 NLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKR 952
++ +LL +C+T+ + LITQLMP GCL+DY+R HK+ IGS+ LNWC QIA+GM YLEE+R
Sbjct: 193 HVCRLLGICLTSTVQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEERR 252
Query: 953 LVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFT 1012
LVHRDLAARNVLV+TP VKITDFGLAKLL +E EY A GGK+PIKW+ALE I HRI+T
Sbjct: 253 LVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRIYT 312
Query: 1013 HKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWM 1072
H+SDVW++GVT+WE++++G++PY+ I A + ++E G +LPQP ICT+D+Y +MV CWM
Sbjct: 313 HQSDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCWM 372
Query: 1073 LDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPE 1132
+DADSRP F++L F++MARDP RYLVI GD+ M LPS + + R L E E
Sbjct: 373 IDADSRPKFRELIAEFSKMARDPPRYLVIQGDERMHLPS---PTDSKFYRTLMEE-EDME 428
Query: 1133 SLVDADEYLQPKFKSMTGTVTTNSALSAGME-TQTSSLKPC 1172
+VDADEYL P T+ + L + + T +S C
Sbjct: 429 DIVDADEYLVPHQGFFNSPSTSRTPLLSSLSATSNNSATNC 469
>UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3
precursor; n=41; cellular organisms|Rep: Receptor
tyrosine-protein kinase erbB-3 precursor - Homo sapiens
(Human)
Length = 1342
Score = 423 bits (1042), Expect = e-116
Identities = 222/575 (38%), Positives = 314/575 (54%), Gaps = 47/575 (8%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+SV + + Y+ L + C V GNLE+ L + DLSFL++IREVTGYVL++ +
Sbjct: 36 LSVTGDAENQYQTLYKLYERCEVVMGNLEIV-LTGHNADLSFLQWIREVTGYVLVAMNEF 94
Query: 61 HKIVLPQLQIIRGRTLFKLNVREEEFALLVTMS-------TAFTLELPALRDVLQGSVGI 113
+ LP L+++RG ++ + +FA+ V ++ L L L ++L G V I
Sbjct: 95 STLPLPNLRVVRGTQVY-----DGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYI 149
Query: 114 YSNFNLCHVKTINWDEINQDLTQVTFTFIILPLGKG--NARVVTQPARWAAGESIENCQK 171
N LCH+ TI+W +I +D ++ G+ V + W G E+CQ
Sbjct: 150 EKNDKLCHMDTIDWRDIVRDRDA---EIVVKDNGRSCPPCHEVCKGRCWGPGS--EDCQT 204
Query: 172 FSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQ 231
+KTIC+PQC G CFGPNP CC+ CAGGC+GP T C ACR+F D G C CP
Sbjct: 205 LTKTICAPQC-NGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPL 263
Query: 232 IYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAV--NG--ECIPC 287
+YN T+ EPNP+ KY YG CV +CP + + D +CVR+CPP+K V NG C PC
Sbjct: 264 VYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPC 323
Query: 288 VGTCPKTCRAE------KPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGER 341
G CPK C + + S NID F +CT I G+++ L TG +N D +
Sbjct: 324 GGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFL---ITG---LNGDP--WHK 375
Query: 342 YPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVK 401
P ++P+ L VF TVRE+TGYLN+Q+ P+ + S F NL IGGR + F+ L +
Sbjct: 376 IPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKN 435
Query: 402 TXXXXXXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQ-CEK 460
+++G I I NR LCY + W K+++ +++ K+ PR+ C
Sbjct: 436 LNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVA 495
Query: 461 NNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYK--ADHKSCKQCHSE 518
VCDP CS+ GCWGPGP QCLSC+NY+ G +C+ +C+ G + A C CH E
Sbjct: 496 EGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPE 555
Query: 519 C--LDG---CTGASRANCTSCKHVRDGPYCVAQCP 548
C ++G C G+ C C H RDGP+CV+ CP
Sbjct: 556 CQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCP 590
Score = 346 bits (851), Expect = 2e-93
Identities = 206/583 (35%), Positives = 307/583 (52%), Gaps = 48/583 (8%)
Query: 632 CHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDEC-----PSDHFTDEIGRNCTPCHSECK 686
C PLC +G C C + RG C C F E C CH EC+
Sbjct: 500 CDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEA--ECFSCHPECQ 557
Query: 687 G------CTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDNI---PNKIYFDEQ 737
C G G C +C + + + P +C +CP + IY
Sbjct: 558 PMEGTATCNGSGSDTCAQCAHFR-----------DGP-HCVSSCPHGVLGAKGPIYKYPD 605
Query: 738 LQDPIEEPY--CSEHANDIPTATARTSTVLVI--------ILVIASLFLAVLAIIGYNFR 787
+Q+ + C++ T+++I + VIA L + + + G
Sbjct: 606 VQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLY 665
Query: 788 QKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVY 847
+ + + M L E EPL P+ K N RI KE ELR+ +LG G FG V+
Sbjct: 666 WRGRRIQNKRAMRRYLERGESIEPLDPSE-KANKVLARIFKETELRKLKVLGSGVFGTVH 724
Query: 848 KGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMM 907
KGVW+PEGE++KIPV IKV+++ +G + + + + S++H ++++LL +C + +
Sbjct: 725 KGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQ 784
Query: 908 LITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQT 967
L+TQ +PLG L+D+VR H+ +G + LNW QIA+GM YLEE +VHR+LAARNVL+++
Sbjct: 785 LVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS 844
Query: 968 PNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEI 1027
P+ V++ DFG+A LL ++ + + K PIKW+ALE I +TH+SDVW++GVT+WE+
Sbjct: 845 PSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWEL 904
Query: 1028 LSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADT 1087
+++GA PY + VP+L+E G +L QP ICT+D+Y VMV CWM+D + RPTFK+LA+
Sbjct: 905 MTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANE 964
Query: 1088 FAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDADEYLQPKFKS 1147
F MARDP RYLVI + P + E + N E +D D L+ + +
Sbjct: 965 FTRMARDPPRYLVIKRESG---PGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDN 1021
Query: 1148 MTGTVTTNSALSAGMET-----QTSSLKPCTSSSWPNNAGQDG 1185
+ T T SALS + T + SL +S P N G G
Sbjct: 1022 L-ATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLG 1063
Score = 99 bits (238), Expect = 4e-19
Identities = 61/206 (29%), Positives = 94/206 (45%), Gaps = 24/206 (11%)
Query: 350 LEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXXXXXX 409
L +REVTGY+ V + F++L NL V+ G QV + FA ++
Sbjct: 74 LSFLQWIREVTGYVLVAMNE--FSTLP-LPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHA 130
Query: 410 ------XXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNL 463
+ SG + I +N LC+ D I W +V+ +D + +++ NG R C +
Sbjct: 131 LRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG--RSCPPCHE 188
Query: 464 VCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGC 523
VC +C WGPG + C + IC C+ H + + C CH EC GC
Sbjct: 189 VCKGRC-----WGPGSEDCQTLTK----TICAPQCNGH--CFGPNPNQC--CHDECAGGC 235
Query: 524 TGASRANCTSCKHVRDGPYCVAQCPE 549
+G +C +C+H D CV +CP+
Sbjct: 236 SGPQDTDCFACRHFNDSGACVPRCPQ 261
Score = 50.4 bits (115), Expect = 3e-04
Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 13/93 (13%)
Query: 452 NGDPRQC--EKNNLVCDPQCSA-DG---CWGPGPDQCLSCQNYNFGEICIDNC-----SV 500
NG+PR+ E C P+C +G C G G D C C ++ G C+ +C
Sbjct: 537 NGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGA 596
Query: 501 HPGLYKAD--HKSCKQCHSECLDGCTGASRANC 531
+YK C+ CH C GC G +C
Sbjct: 597 KGPIYKYPDVQNECRPCHENCTQGCKGPELQDC 629
Score = 48.4 bits (110), Expect = 0.001
Identities = 28/94 (29%), Positives = 36/94 (38%), Gaps = 13/94 (13%)
Query: 617 NVKPLEGKVKIACRKCHPLCIKCVGF----GIHEQVCQVCNGFKRGDQCEDECPSD---- 668
N +P E + C CHP C G G C C F+ G C CP
Sbjct: 537 NGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGA 596
Query: 669 ----HFTDEIGRNCTPCHSEC-KGCTGPGPTDCI 697
+ ++ C PCH C +GC GP DC+
Sbjct: 597 KGPIYKYPDVQNECRPCHENCTQGCKGPELQDCL 630
Score = 48.0 bits (109), Expect = 0.002
Identities = 38/124 (30%), Positives = 52/124 (41%), Gaps = 23/124 (18%)
Query: 195 CNTFCA-GGCTGPLPTQCLACRNFYDEGTCSQECPSMQIYNPTTYSWEP-----NPNGKY 248
C+ C+ GGC GP P QCL+CRN+ G C C + P ++ E +P +
Sbjct: 500 CDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLN-GEPREFAHEAECFSCHPECQP 558
Query: 249 AYG-ATCVRN----CPEHL-LKDNGACVRSCPPNKTAVNG----------ECIPCVGTCP 292
G ATC + C + +D CV SCP G EC PC C
Sbjct: 559 MEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCT 618
Query: 293 KTCR 296
+ C+
Sbjct: 619 QGCK 622
Score = 41.5 bits (93), Expect = 0.16
Identities = 25/76 (32%), Positives = 33/76 (43%), Gaps = 11/76 (14%)
Query: 628 ACRKCHPLCI-KCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECK 686
+C CH +C +C G G + CQ QC C + C CH EC
Sbjct: 182 SCPPCHEVCKGRCWGPGSED--CQTLTKTICAPQCNGHCFGPN-----PNQC--CHDECA 232
Query: 687 G-CTGPGPTDCIKCKN 701
G C+GP TDC C++
Sbjct: 233 GGCSGPQDTDCFACRH 248
Score = 40.3 bits (90), Expect = 0.37
Identities = 15/23 (65%), Positives = 16/23 (69%), Gaps = 1/23 (4%)
Query: 675 GRNCTPCHSECKG-CTGPGPTDC 696
GR+C PCH CKG C GPG DC
Sbjct: 180 GRSCPPCHEVCKGRCWGPGSEDC 202
>UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1; Ciona
intestinalis|Rep: Epidermal growth factor receptor -
Ciona intestinalis (Transparent sea squirt)
Length = 878
Score = 420 bits (1035), Expect = e-115
Identities = 199/340 (58%), Positives = 262/340 (77%), Gaps = 8/340 (2%)
Query: 810 EPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPE---GENVKIPVAIKV 866
EP+ P+ V PN A+LRIVKEAELR G +LG GAFG V+KG W+P+ E VK+PVAIKV
Sbjct: 101 EPMTPSGVAPNQAQLRIVKEAELRIGKILGSGAFGTVHKGYWIPDLAPRERVKVPVAIKV 160
Query: 867 LKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHK 926
L++ + S E L+EA++MAS EHPNL++LL + ++ ++MLITQLMPLG L++YVR +K
Sbjct: 161 LRDESSQVASNEILDEAFVMASCEHPNLVRLLGISLSQRIMLITQLMPLGNLLEYVRDNK 220
Query: 927 EKIGSKAFLNWCTQIARGMAYL-EEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDIN 985
+ IGS+ LNW QIA+GM YL EEK LVHRDLAARNVLV++PN V+ITDFGLAKLLD+
Sbjct: 221 DNIGSQHLLNWSLQIAKGMKYLSEEKHLVHRDLAARNVLVKSPNHVRITDFGLAKLLDVK 280
Query: 986 EDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPE 1045
ED Y+A GGKMPIKWLALE IQHRIFT KSDVW+FGVT+WE++++G +PYE++ AR V
Sbjct: 281 EDVYRAEGGKMPIKWLALESIQHRIFTQKSDVWSFGVTMWELMTFGKKPYESVPAREVHT 340
Query: 1046 LIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDK 1105
L+E G +LPQP ICT+DIY +++ CW +DA++RPTFK+L + +++ARDP RYLVI D
Sbjct: 341 LLERGERLPQPYICTIDIYMLLIKCWTVDAEARPTFKELTEELSKLARDPQRYLVIDNDG 400
Query: 1106 FMR-LPSYSTQDEKEMIRNLSSAMEGPESLVDADEYLQPK 1144
+ LPS +T E +R+L + + DA+EYL P+
Sbjct: 401 LLTDLPSPTT---SEFLRSLVNDEGDDFPITDAEEYLHPQ 437
>UniRef50_Q5G254 Cluster: Erbb3; n=6; Danio rerio|Rep: Erbb3 - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1429
Score = 411 bits (1011), Expect = e-113
Identities = 218/570 (38%), Positives = 305/570 (53%), Gaps = 36/570 (6%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+S + HY NL++R+T C V GNLE+T +EN+ +D SFL IREVTGY+LI+ +
Sbjct: 35 LSSTGTPEQHYNNLKERYTGCEIVMGNLEITQMEND-LDFSFLGSIREVTGYILIAMNQF 93
Query: 61 HKIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSVGIYSNFNLC 120
K+ L QL++IRG +L+ F T + L L L ++L+G V I N NL
Sbjct: 94 RKLPLNQLRVIRGSSLYDKEWALSVFHNFDTHTGLEDLGLTNLTEILEGGVQIVHNRNLS 153
Query: 121 HVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKTICSPQ 180
+ INW +I +D I G+G+ W G S + CQK +KT+C+ Q
Sbjct: 154 YAPLINWQDIVRDGD--ARIQIQDNGGRGSCNPACGEFCW--GPSNDQCQKLTKTVCALQ 209
Query: 181 CAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQIYNPTTYSW 240
C G CFG NP +CC+ CAGGCTGP T C ACR+ G+C CP +YN T+
Sbjct: 210 CL-GHCFGTNPNECCHPECAGGCTGPRDTDCFACRHVNYSGSCVPHCPWPVVYNQQTFQV 268
Query: 241 EPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAVN----GECIPCVGTCPKTCR 296
EPN + Y +G+ CV CP H + D ACV SCPP KT + +C C+G CPK C
Sbjct: 269 EPNADAMYQFGSICVPKCPGHFVVDGSACVSSCPPGKTEIEKNQIKQCETCIGLCPKVCE 328
Query: 297 A-----EKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALE 351
+ + S NIDSF +CT I GS+ L + G N P +EP+ L+
Sbjct: 329 GTGANHRQTVDSSNIDSFINCTKIQGSLHFLILGIKGDVYNN--------IPPLEPEKLK 380
Query: 352 VFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVV--ENLFASLYIVKTXXXXXXX 409
VF+TVRE+TG LN+Q+ LS F +L I GR + F+ L +
Sbjct: 381 VFNTVREITGILNIQSWPDELHDLSVFSSLTTIQGRSLYNPNTPFSMLMMKIPSLTSLGL 440
Query: 410 XXXXXVNSGAIAIMENRNLCYADKIAWNKLV---KSKDHKQIIQKNGDPRQCEKNNLVCD 466
++ G++ I +N NLCY I W ++ + + + I++N QCE+ VCD
Sbjct: 441 RSMREISDGSVYITQNMNLCYHHTINWTQIFPRNQLQRRRNDIKENKQKIQCEEEGHVCD 500
Query: 467 PQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVH---PGLYKADHKSCKQCHSECL--- 520
P CS GCWGPGP+QCLSC+NY+ C+ +C+++ P + A +K C CHSECL
Sbjct: 501 PLCSDAGCWGPGPEQCLSCRNYSRLGTCVSHCNLYSGEPREFAASNKECLACHSECLLQN 560
Query: 521 --DGCTGASRANCTSCKHVRDGPYCVAQCP 548
C G C +C ++ DGP+CV+ CP
Sbjct: 561 GKQTCLGKGADQCVACSNLMDGPHCVSSCP 590
Score = 336 bits (825), Expect = 3e-90
Identities = 190/509 (37%), Positives = 279/509 (54%), Gaps = 43/509 (8%)
Query: 622 EGKVKIACRK----CHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECP--SDHFTDEIG 675
E K KI C + C PLC +G + C C + R C C S +
Sbjct: 485 ENKQKIQCEEEGHVCDPLCSDAGCWGPGPEQCLSCRNYSRLGTCVSHCNLYSGEPREFAA 544
Query: 676 RN--CTPCHSEC------KGCTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDN 727
N C CHSEC + C G G C+ C NL + P +C +CP+
Sbjct: 545 SNKECLACHSECLLQNGKQTCLGKGADQCVACSNLM-----------DGP-HCVSSCPNG 592
Query: 728 IPNK----IYFDEQLQDPIEEPY------CSEHA-NDI--PTATARTSTVL-VIILVIAS 773
+ + I+ E + C+ A D P +S + + + V A
Sbjct: 593 VNGEKGQTIFKYSTAAGHCELCHFNCTRGCTGPALRDCVDPDRNVNSSQIAGIAVAVFAG 652
Query: 774 L-FLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAEL 832
+ L L ++G + + +++ + +G E EPL P K RI+K EL
Sbjct: 653 ITVLLALFVLGMLYHRGLAIRRKRALRRYLESG-ESMEPLDPGE-KGTKVHARILKPQEL 710
Query: 833 RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHP 892
R+G +LG+G FG V KG W+PEG+++KIPVAIK ++ + T E + M S++HP
Sbjct: 711 RKGKLLGYGVFGTVNKGFWIPEGDSLKIPVAIKTIQNRSSRQTFTEITDHMLSMGSLDHP 770
Query: 893 NLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKR 952
+++L+ +C + LITQL P G L+ ++R HK+ + + LNWC QIA+GM YLEE
Sbjct: 771 YIVRLIGICPGASLQLITQLSPHGSLLQHLRQHKDSLDPQRLLNWCVQIAKGMYYLEEHC 830
Query: 953 LVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFT 1012
+ HR+LAARN+L+++ V+I+DFG+A LL ++ +Y + K IKW+ALE I +T
Sbjct: 831 MAHRNLAARNILLKSDYIVQISDFGVADLLYPDDKKYVYSEHKTSIKWMALESILFGRYT 890
Query: 1013 HKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWM 1072
H+SDVW++GVT+WE++SYGA PY ++ +VP L+E G +L QP ICT+D+Y VMV CWM
Sbjct: 891 HQSDVWSYGVTVWEMMSYGAEPYASMHPHDVPGLLEKGERLAQPQICTIDVYMVMVKCWM 950
Query: 1073 LDADSRPTFKQLADTFAEMARDPGRYLVI 1101
+D + RPTFK+LA F MARDP RYLV+
Sbjct: 951 IDENVRPTFKELASEFTRMARDPPRYLVV 979
Score = 50.0 bits (114), Expect = 5e-04
Identities = 29/95 (30%), Positives = 42/95 (44%), Gaps = 15/95 (15%)
Query: 452 NGDPRQCEKNN---LVCDPQCSADG----CWGPGPDQCLSCQNYNFGEICIDNC----SV 500
+G+PR+ +N L C +C C G G DQC++C N G C+ +C +
Sbjct: 536 SGEPREFAASNKECLACHSECLLQNGKQTCLGKGADQCVACSNLMDGPHCVSSCPNGVNG 595
Query: 501 HPGL----YKADHKSCKQCHSECLDGCTGASRANC 531
G Y C+ CH C GCTG + +C
Sbjct: 596 EKGQTIFKYSTAAGHCELCHFNCTRGCTGPALRDC 630
Score = 42.3 bits (95), Expect = 0.091
Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 4/90 (4%)
Query: 462 NLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLD 521
N C P+C A GC GP C +C++ N+ C+ +C P +Y + +++ +
Sbjct: 220 NECCHPEC-AGGCTGPRDTDCFACRHVNYSGSCVPHCP-WPVVYNQQTFQVEP-NADAMY 276
Query: 522 GCTGASRANCTSCKHVRDGPYCVAQCPESR 551
C V DG CV+ CP +
Sbjct: 277 QFGSICVPKCPG-HFVVDGSACVSSCPPGK 305
Score = 36.3 bits (80), Expect = 5.9
Identities = 13/23 (56%), Positives = 16/23 (69%), Gaps = 1/23 (4%)
Query: 681 CHSECKG-CTGPGPTDCIKCKNL 702
CH EC G CTGP TDC C+++
Sbjct: 223 CHPECAGGCTGPRDTDCFACRHV 245
>UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; Ciona
intestinalis|Rep: Epidermal growth factor receptor -
Ciona intestinalis (Transparent sea squirt)
Length = 1462
Score = 400 bits (986), Expect = e-109
Identities = 257/686 (37%), Positives = 361/686 (52%), Gaps = 52/686 (7%)
Query: 629 CRKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECKG- 687
C C C+ C FK QC CP +++ + + C+ C C G
Sbjct: 634 CLPCDSECLSTCNGPTSYNCTSGCQNFKLNSQCVPSCPLNYYIG-LNKTCSACSPNCVGG 692
Query: 688 CTGPGPTDCIK---CKNLKIFLGGSDASDENAPFNCTDTCPDNIPNKIYFDEQLQDPIEE 744
CTG P D C + + + + + C D + +
Sbjct: 693 CTG--PLDIYGEGGCSSCHVSMDEKTSVYTHRGAKCPFCLNDQLRETCAHGCTSFNNTGR 750
Query: 745 PYCSEHANDIPTATARTSTVLVIILVIASLFL-AVLAIIGYNFRQKAKAKKEAVKMTMV- 802
C +P TV +II V+ +F+ V++ + Y R+ K ++ + TMV
Sbjct: 751 LQCYY----LPKPDI---TVYIIIGVMVFIFIFIVISWVFYKHRKTIKRMRQTIGETMVG 803
Query: 803 --LTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVP---EGEN 857
+ + PL P+ PN+A+LRIVKE+EL MLG GAFG V K +W P +GE
Sbjct: 804 ERIPLEPEAVPLTPSGAAPNVAQLRIVKESELEFRKMLGSGAFGTVQKAIWTPLNIQGEK 863
Query: 858 VKIPVAIKVLK--ETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPL 915
VKI VA+K LK E + + E ++EAY+MASVE P L++LL + MT Q+ LITQLMPL
Sbjct: 864 VKIAVAVKTLKTSEDLLQSANNEIMDEAYMMASVECPYLVRLLGISMTEQVALITQLMPL 923
Query: 916 GCLVDYVR--THKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKI 973
G L++YVR T ++ I S+ L+WC QIA+GM YLEEK LVHRDLAARNVLV+TPN VKI
Sbjct: 924 GSLLEYVRNPTTRDSIRSRQILSWCVQIAKGMKYLEEKHLVHRDLAARNVLVKTPNHVKI 983
Query: 974 TDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGAR 1033
TDFGLAK+LD E+ Y A GGK+PIKWLA+ECI R F+H SDVWAFGVT WE+L++GAR
Sbjct: 984 TDFGLAKMLDTKEEIYHAEGGKLPIKWLAIECITEREFSHLSDVWAFGVTCWELLTFGAR 1043
Query: 1034 PYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMAR 1093
PYE + A +V L+E G +LPQP+ T+DIY V+V CWM+D RP+F L D F++MA
Sbjct: 1044 PYEGVRAVDVLSLLERGDRLPQPATSTIDIYMVLVKCWMVDRLCRPSFSNLVDEFSKMAA 1103
Query: 1094 DPGRYLVIPGDKFMRLPSYSTQDEKEMIRNL-SSAMEGPESLV--DADEYL--------Q 1142
DP R++VI D + S ++ D+ R L E L+ + DEYL
Sbjct: 1104 DPSRFVVIKHDDTDNIMSPTSVDDASFFRQLMEDEKTAEEDLIADEPDEYLLNLNHPDNL 1163
Query: 1143 PKFKSMTGTVTTN---SALSAGMETQTSSLKPCTSSSWPNNAGQDGVP--DPSTKPENWD 1197
PK+ ++ + A A + ++ + SS+ + AG P P P++
Sbjct: 1164 PKYANIAHDPPQHPDQGARDARLFSRNTPSSFPESSTSSSTAGMRAEPPVTPQADPDDVF 1223
Query: 1198 HEMLRYNNQLNPDGSEVRHYYNNGVCASDTSSSRYCSDPMKTRTEVSLEDNFDGMSKAKE 1257
E++ ++P + V N + +T RY DP R + DGM
Sbjct: 1224 SEVVNSVKTVSPHPTSVEQQATNRKDSEET--QRYTEDPTTKRPLL------DGMQSPTT 1275
Query: 1258 AQVGNLKLNLPLDEDDYLMPSPQHTQ 1283
N +DE++YL+P+P Q
Sbjct: 1276 LYKPNPG---EVDENNYLLPTPLKKQ 1298
Score = 192 bits (469), Expect = 4e-47
Identities = 185/658 (28%), Positives = 276/658 (41%), Gaps = 100/658 (15%)
Query: 6 NRDTHYRNLRDRFTNCTYVDGNLELTWL--ENESMDLSFLKYIREVTGYVLISHVKVHKI 63
+R+ Y NL +TNCT V+GNLELT L + F K+I +VTGY+LI + I
Sbjct: 75 SREIQYSNLEKLYTNCTLVNGNLELTGLFPFGNITTIEFTKHIEQVTGYLLIYRTIMDSI 134
Query: 64 VLPQLQIIRGRTLFKLNV---------REEE----FALLVTMSTAFTLEL--PALRDVLQ 108
L L++IRG T + + V R++ +A +T + EL P L ++
Sbjct: 135 NLSSLRLIRGLTQYYIGVDCRTNLTLARDQPGYSVYANRITGDQNYLRELWMPKLTEISA 194
Query: 109 GSVGIYSNFNLCHVKTINW-DEINQDLTQVTFTFIILPLGKGNARVV---------TQPA 158
G+V ++ +C++++I W DEI D +Q T P+ + P
Sbjct: 195 GNV-FFTKSRICNLESIKWRDEIFNDGSQ-TVEITNDPVRDRYCDPCPSVCRDDSGSTPV 252
Query: 159 RWAAGESIENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGC------TGPLPTQCL 212
G S + CQ +K+ C QC RC CCN CAGGC TG C
Sbjct: 253 NRCWGNSSDLCQLITKSKCRRQCGNDRCNAGGA--CCNGKCAGGCYDNMPATGNKDKWCH 310
Query: 213 ACRNFYDEGTCSQECPSMQIYNPT-TYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVR 271
AC++ + GTC + CP NPT T + P Y + CV CP ++ + C
Sbjct: 311 ACKDMNNNGTCVEACPQGTQMNPTSTITKTPK---TYQFARYCVPKCPFNVPQTTSFCRT 367
Query: 272 SCPPNKTAVNGE-CIPCV-GTCPKTC----------RAEKPIHSGNIDSF-KDCTIIDGS 318
CP N C PC G C C + +K I+S NI F K+CTII+GS
Sbjct: 368 YCPEGTFDYNSNICEPCENGKCEHVCYGLGVGHGPLKDDKEINSENIKYFNKNCTIIEGS 427
Query: 319 IEILEMTFTGFQQVNQDYSFGERYPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYF 378
+ TF G Y + +E L VF V+E+TGYL + L F
Sbjct: 428 LSFQASTFNG-----DSYCSIGKLNNLE--MLSVFENVKEITGYLAFDEWRMH--DLCLF 478
Query: 379 RNLEVIGGRQVVENLFASLYIVKTXXXXXXXXXXXXVN--SGAIAIMENRNLCYADKIAW 436
+NL+ I G+++ L+ SLY+ N G + ++ N L + D I W
Sbjct: 479 KNLKKIRGKELKSELY-SLYVYTNDKSLRELCLNSLENIYDGGVLVVRNPRLGHTDTITW 537
Query: 437 NKLVK-SKDHKQIIQKNGDPRQCEKNNLVCDPQCSADGCWGPGPDQCLSCQNYN-----F 490
+ S + +I +N C + +CD + GCWG C+ CQ Y
Sbjct: 538 ENIFSDSGNQNTMILRNQKEVPC---HTMCD---QSQGCWGRDATNCVRCQYYTDYTDVN 591
Query: 491 GEIC---IDNCSVHPGLYKADHKSC-KQCHSE----------CL-------DGCTGASRA 529
G++ + + + + + +C +QC+ E CL C G +
Sbjct: 592 GQLTPAWVTDQTTGLAVPGYNTTTCVEQCNQEKGVYASSDMRCLPCDSECLSTCNGPTSY 651
Query: 530 NCTS-CKHVRDGPYCVAQCPESRYASEXXXXXXXXXXXXXXXXXXANTVGEGGCNSCN 586
NCTS C++ + CV CP + Y + GEGGC+SC+
Sbjct: 652 NCTSGCQNFKLNSQCVPSCPLNYYIGLNKTCSACSPNCVGGCTGPLDIYGEGGCSSCH 709
Score = 37.1 bits (82), Expect = 3.4
Identities = 22/60 (36%), Positives = 25/60 (41%), Gaps = 6/60 (10%)
Query: 169 CQKFS-KTICSPQCAQGRCFGPNPR-DCCNTFCAGGCTGPLPTQ----CLACRNFYDEGT 222
CQ F + C P C G N C+ C GGCTGPL C +C DE T
Sbjct: 657 CQNFKLNSQCVPSCPLNYYIGLNKTCSACSPNCVGGCTGPLDIYGEGGCSSCHVSMDEKT 716
>UniRef50_Q4RQT4 Cluster: Chromosome 2 SCAF15004, whole genome shotgun
sequence; n=2; Tetraodon nigroviridis|Rep: Chromosome 2
SCAF15004, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 996
Score = 370 bits (910), Expect = e-100
Identities = 176/318 (55%), Positives = 234/318 (73%), Gaps = 25/318 (7%)
Query: 848 KGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMM 907
+G+WVPEGE VKIPVA+K+L E TG + EF++EA IMAS+EHP+L++LL VC++ +
Sbjct: 320 EGIWVPEGEKVKIPVAVKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ 379
Query: 908 LITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIAR----------GMAYLEEK------ 951
L+TQLMP GCL+DYV HK+ IGS+ LNWC QIA+ G+ + ++
Sbjct: 380 LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKVLQWKVTGAYGLPEMSKEVSQTPL 439
Query: 952 RLVH-----RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECI 1006
R +H RDLAARNVLV++PN +KITDFGLA+LLD+NE EY A GGKM IKW+ALECI
Sbjct: 440 RFMHFRAKWRDLAARNVLVKSPNHIKITDFGLARLLDVNEKEYNADGGKMAIKWMALECI 499
Query: 1007 QHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCV 1066
+R FTH+SDVW++GVTIWE++++G +PY+ IS R++P+L+E G +LPQP I T+D+Y V
Sbjct: 500 HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPISTIDVYMV 559
Query: 1067 MVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSS 1126
MV CWM+DADSRP FK+LA F MARDP RYLVI GD M+LP ++ + ++L
Sbjct: 560 MVKCWMIDADSRPKFKELAAEFTRMARDPQRYLVIQGDDCMKLPG---PNDSKFFQSL-L 615
Query: 1127 AMEGPESLVDADEYLQPK 1144
A E E L+DA+EYL P+
Sbjct: 616 AEEQLEDLMDAEEYLVPQ 633
Score = 176 bits (428), Expect = 4e-42
Identities = 96/265 (36%), Positives = 141/265 (53%), Gaps = 26/265 (9%)
Query: 287 CVGTCPKTCRAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKME 346
C G + + + S NID F +CT I+G++ L TG + Y ++
Sbjct: 7 CDGIGTASLHMHQTVDSSNIDKFVNCTKINGNLVFL---ITGIK--GDVY---HNIEALD 58
Query: 347 PDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXXX 406
P+ L VF TVREVTG+LN+Q+ N T LS F NL IGGR +LY ++
Sbjct: 59 PEKLNVFRTVREVTGFLNIQSWPDNMTDLSVFSNLATIGGR--------ALYRIQNEHLK 110
Query: 407 XXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNLVCD 466
+++G + I EN LCY + I W +L ++ + K +I+ N P QC K ++VCD
Sbjct: 111 LQSLRE--ISAGNVHIEENSQLCYYNTINWTRLFRTSNQKALIRNNQSPEQCSKKHMVCD 168
Query: 467 PQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYK--ADHKSCKQCHSECLDGCT 524
P CS GCWGPGPDQCLSC+ + G C+D C+++ G + A+ C +C +C
Sbjct: 169 PLCSDAGCWGPGPDQCLSCKYFIRGRTCVDRCNLYEGEIREYANGSMCVECDGQC----- 223
Query: 525 GASRANCTSCKHVRDGPYCVAQCPE 549
+ + +C H DGP CV +CP+
Sbjct: 224 ELADDDSLTC-HGPDGPNCVEKCPD 247
Score = 61.3 bits (142), Expect = 2e-07
Identities = 77/294 (26%), Positives = 115/294 (39%), Gaps = 65/294 (22%)
Query: 16 DRFTNCTYVDGNLE--LTWLEN------ESMD---LSFLKYIREVTGYVLISHVKVHKI- 63
D+F NCT ++GNL +T ++ E++D L+ + +REVTG++ I +
Sbjct: 27 DKFVNCTKINGNLVFLITGIKGDVYHNIEALDPEKLNVFRTVREVTGFLNIQSWPDNMTD 86
Query: 64 --VLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSVGIYSNFNLCH 121
V L I GR L++ ++ E L+L +LR++ G+V I N LC+
Sbjct: 87 LSVFSNLATIGGRALYR--IQNEH------------LKLQSLREISAGNVHIEENSQLCY 132
Query: 122 VKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKTICSPQC 181
TINW + R Q A +S E C K +C P C
Sbjct: 133 YNTINWTRL--------------------FRTSNQKALIRNNQSPEQCSK-KHMVCDPLC 171
Query: 182 AQGRCFGPNPRDC--CNTFCAG-GCTGPLPTQCLACRNFYDEGTCSQECPSM-QIYNPTT 237
+ C+GP P C C F G C R Y G+ EC ++ + +
Sbjct: 172 SDAGCWGPGPDQCLSCKYFIRGRTCVDRCNLYEGEIRE-YANGSMCVECDGQCELADDDS 230
Query: 238 YSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAVNGECIPCVGTC 291
+ P+ G CV CP+ L N + N EC PC C
Sbjct: 231 LTCH-GPD-----GPNCVEKCPDGLQGANSFIFK-----YAEANNECHPCHANC 273
>UniRef50_Q68KJ7 Cluster: HER2; n=3; Amniota|Rep: HER2 - Felis
silvestris catus (Cat)
Length = 304
Score = 367 bits (902), Expect = 1e-99
Identities = 165/298 (55%), Positives = 226/298 (75%)
Query: 766 VIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLR 825
+I V+ L + V+ ++ ++ + K M +L E EPL P+ PN A++R
Sbjct: 7 IIAAVVGILLVVVVGLVLGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMR 66
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYI 885
I+KE ELR+ +LG GAFG VYKG+W+P+GENVKIPVAIKVL+E T +KE L+EAY+
Sbjct: 67 ILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYV 126
Query: 886 MASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGM 945
MA V P + +LL +C+T+ + L+TQLMP GCL+D+VR H+ ++GS+ LNWC QIA+GM
Sbjct: 127 MAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGM 186
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALEC 1005
+YLE+ RLVHRDLAARNVLV++PN VKITDFGLA+LLDI+E EY A GGK+PIKW+ALE
Sbjct: 187 SYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALES 246
Query: 1006 IQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDI 1063
I R FTH+SDVW++GVT+ E++++GA+PY+ I AR +P+L+E G +LPQP ICT+D+
Sbjct: 247 ILRRRFTHQSDVWSYGVTVRELMTFGAKPYDGIPAREIPDLVEKGERLPQPPICTIDV 304
>UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 1193
Score = 330 bits (811), Expect = 2e-88
Identities = 174/430 (40%), Positives = 254/430 (59%), Gaps = 14/430 (3%)
Query: 678 CTPCHSECKGCTGPGPTDCIKC---KNLKIFLGG--SDASDENAPFNCTDTCPDNIPNKI 732
C PC+ C CTGPG T C C K L + + G +D ++A NC I
Sbjct: 686 CLPCNDVCASCTGPGNTSCTTCRYAKRLALCVSGCSNDTEYQDAALNCLPCAAGCIGCS- 744
Query: 733 YFDEQLQDPIEEPYCSEHANDIPTATARTSTVL--VIILVIASLFLAVLAIIGYNFRQKA 790
+ + S D+ ++ V ++++ +A+ + +L I+ Y R +
Sbjct: 745 --GPSISQCLTCASGSCTTTDVQSSGGIIGIVFGSIVVIFLATSIVLILFIV-YR-RYEH 800
Query: 791 KAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGV 850
K K + T + NE LRP + P+ +L I E L +G +LG GAFG VYKG
Sbjct: 801 KVFKNRTQSTAMCYS-NGNETLRPPKLPPDATRLIITPETALEQGQVLGSGAFGTVYKGH 859
Query: 851 WVPEGENVKIPVAIKVLKETTGANTSK-EFLEEAYIMASVEHPNLLQLLAVCMTNQMMLI 909
W PEG+ VAIKVLKE T S+ E L E +MA+++H N+++L VCM QMMLI
Sbjct: 860 WRPEGDPNCYEVAIKVLKEETATPQSQTELLREGAVMATMDHINVVRLYCVCMGKQMMLI 919
Query: 910 TQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPN 969
T+ + LG L+ Y++ ++ + + + LN+ QIA GMAYLEEKR+VHRDLAARNVLV TP
Sbjct: 920 TEFVRLGSLLSYLKNNQATLDAYSMLNFSRQIADGMAYLEEKRMVHRDLAARNVLVHTPQ 979
Query: 970 SVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILS 1029
VKITDFGL +++D+ E YKA GG +P++W+A E I +THKSDVW+FGVTIWEIL+
Sbjct: 980 LVKITDFGLTRIIDVGESHYKATGGMVPLRWMAPESIFLFEYTHKSDVWSFGVTIWEILT 1039
Query: 1030 YGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFA 1089
+G PY+ + + V +L++NG +L +P+ C ++Y ++ CW+ D RP+F L+++
Sbjct: 1040 FGRLPYKGKNGKEVSQLVKNGQQLERPATCDANLYHLLEQCWLHDQTKRPSFSALSNSLN 1099
Query: 1090 EMARDPGRYL 1099
M DP RY+
Sbjct: 1100 VMLNDPTRYI 1109
Score = 305 bits (749), Expect = 5e-81
Identities = 217/734 (29%), Positives = 319/734 (43%), Gaps = 80/734 (10%)
Query: 14 LRDRFTNCTYVDGNLELTWLENESMDL---SF--LKYIREVTGYVLISHVK-VHKIVLPQ 67
L RF CT + GNL + E +L SF L ++REV+GY+ S++ V +I LP
Sbjct: 53 LAARFCGCTRISGNLAIHLNLQEDANLTEDSFASLYHLREVSGYLQFSNIPAVTRITLPN 112
Query: 68 LQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSVGIYSNFNLCHVKTINW 127
L++IRG+T L+ +LLV S ++ LP+L ++ G S +C +NW
Sbjct: 113 LRVIRGQTA--LSSTNGPVSLLVENSRIGSVNLPSLTEISNGGATFVSTNGMCGFLGVNW 170
Query: 128 DEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKTICSPQCAQGRCF 187
+I + Q+ ++ + + W+ S CQ +KT+C C GRCF
Sbjct: 171 ADILTN-GQLDYSMSGCKVTTLDCSSCPSGHCWS---SPHYCQTLTKTVCPQGC--GRCF 224
Query: 188 ---GPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQIYNPTTYSWEPNP 244
G CC+ CA GC+GP QC AC + GTC ECP Q+Y+P + NP
Sbjct: 225 QSPGDGSYQCCSALCAAGCSGPTSDQCYACSILDNNGTCVTECPPAQVYDPDLFMLVDNP 284
Query: 245 NGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAVNG-ECIPC-VGTCPKTC--RAEKP 300
N + A G CV+ C +LL+ GACV CP T+ NG +C+ C G CP+ C
Sbjct: 285 NYRLASGDLCVQQCAGNLLEYAGACVTFCPEGYTSNNGAKCVACSSGVCPRVCTGTGTDG 344
Query: 301 IHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALEVFSTVREVT 360
+ +GNI F CTI++GS+ I + + M LE+ ST++EV
Sbjct: 345 LGAGNIGQFNSCTIVNGSLSISDTSI------------------MSGANLELLSTIQEVQ 386
Query: 361 GYLNVQAHHPNFTSLSYFRNLEVIG------GRQVVE-NL-------FASLYIVKTXXXX 406
GYL ++ + TS Y RNL+ +G R + NL SL ++ T
Sbjct: 387 GYLRIEGLN-TVTSFPYLRNLKTVGFPGAAYNRSITRTNLCQPGGYQLYSLMVLSTSLQS 445
Query: 407 XXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNG---DPRQCEKNNL 463
+ G + N LCY + +L S + + DP C
Sbjct: 446 IDFSSLRSIQYGGYILGRNPQLCYVGNFS-RRLADSNAPVCLSTSSAYRKDPSSCIAAGF 504
Query: 464 VCDPQCSAD-GCWGPGPDQCLSCQNYNFGEICIDNCS---VHP---GLYKADHKS-CKQC 515
VC PQCS++ CWGP QC C+++ + C+ CS + P G+Y+ + C+ C
Sbjct: 505 VCHPQCSSNSSCWGPNDTQCDGCRSFVYKGRCVAQCSDVVLSPGNSGIYQNNGSGVCEDC 564
Query: 516 HSECLDGC-TGASRANCTSCKH----VRDGPYCVAQCPESRYASEXXXXXXXXXXXXXXX 570
S+CL GC G +C C++ + GP CVA CP Y +
Sbjct: 565 DSQCLGGCVNGTDPYHCIRCRNYTLVTQTGPLCVASCPLGTYTNGTMCIPCFQGCTGGCA 624
Query: 571 XXXANTVGEGGCNSCNKAIISVEATVESCLKEDEPCPDGYYNEWV--GNVKPLEG---KV 625
GC C + + ++ + + CP Y GN K L V
Sbjct: 625 GPLPYVNLTNGCLGC--SYVHLDQLGQQVICNSSGCPSSTYQSSTPPGNSKQLLSIIQDV 682
Query: 626 KIACRKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSEC 685
C C+ +C C G G C C KR C C +D + NC PC + C
Sbjct: 683 TTLCLPCNDVCASCTGPG--NTSCTTCRYAKRLALCVSGCSNDTEYQDAALNCLPCAAGC 740
Query: 686 KGCTGPGPTDCIKC 699
GC+GP + C+ C
Sbjct: 741 IGCSGPSISQCLTC 754
>UniRef50_Q4RXV8 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14979, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1547
Score = 322 bits (792), Expect = 3e-86
Identities = 203/541 (37%), Positives = 274/541 (50%), Gaps = 76/541 (14%)
Query: 46 IREVTGYVLISHVKVHKIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFT-------L 98
IREVTGY+L++ ++ L L++IRG L+ E ++AL+V ++ L
Sbjct: 86 IREVTGYILLAVNTFSRLPLDNLRVIRGNELY-----ENQYALVVMINYPTKGGQGLQEL 140
Query: 99 ELPALRDVLQGSVGIYSNFNLCHVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPA 158
L L ++LQG V I N +L +NW +I +D T F P + P
Sbjct: 141 GLTHLTEILQGGVKITQNRDLSFAPKVNWLDIVKDGTANITIFDNGPEKPCHKACGDVPC 200
Query: 159 RWAAGESIENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFY 218
W G + CQ +KT+C+PQC RCFG +P +CC++ CAGGCTGPL T C ACR F
Sbjct: 201 -WGPGSDM--CQILTKTVCAPQC-NFRCFGRSPGECCHSECAGGCTGPLDTDCFACRKFN 256
Query: 219 DEGTCSQECPSMQIYNPTTYSWEPNPNGKYAYGATCVRNC----PEHLLK---------- 264
D G+C +CP IYN T+ EPNPN K+ +G+ CV C P LL+
Sbjct: 257 DSGSCVPQCPMALIYNKYTFRLEPNPNAKFQFGSICVAQCPRQYPPRLLRLKSASSFVFI 316
Query: 265 --------------DNGACVRSCPPNKTAV--NG--ECIPCVGTCPKTCRAE-----KPI 301
D +CVRSCP +K V NG C PC G CPK C + +
Sbjct: 317 PALLCFLYSANFLVDGTSCVRSCPADKMEVEKNGVKRCEPCGGLCPKACHGTGSPNGETV 376
Query: 302 HSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALEVFSTVREVTG 361
+ NIDSF +CT I GS+ L TG N + P ++P+ L++F+TVRE+T
Sbjct: 377 DALNIDSFINCTKIQGSLHFL---LTGINGDNYN-----NVPPLDPEKLKIFNTVREITD 428
Query: 362 YLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKT-XXXXXXXXXXXXVNSGAI 420
L +Q+ N + LS F NL+ I GR++ + SL +VKT +N G +
Sbjct: 429 MLVIQSWPTNMSDLSVFSNLQTIQGRKLYKGY--SLMVVKTPSLTSLGLRSLRKINDGGV 486
Query: 421 AIMENRNLCYADKIAWNKLVKSKD-----HKQIIQKNGDPRQ-CEKNNLVCDPQCSADGC 474
I N+NLCY D + W L+ S HK I K+ PR C + N VCDP CS+DGC
Sbjct: 487 YITGNKNLCYHDTVNWTLLLGSSSRQQRRHKNIDIKDNRPRSDCVRENFVCDPLCSSDGC 546
Query: 475 WGPGPDQCLSCQNYNFGEICIDNCSVHPG---LYKADHKSCKQCHSECLDGCTGASRANC 531
WGPGP QCLSC+ Y+ G IC+ +C G + C CH EC TG R C
Sbjct: 547 WGPGPSQCLSCKKYSRGGICVADCMFLAGDRREFATASGECMPCHPEC-KAQTG--RETC 603
Query: 532 T 532
T
Sbjct: 604 T 604
Score = 199 bits (486), Expect = 4e-49
Identities = 92/175 (52%), Positives = 128/175 (73%), Gaps = 5/175 (2%)
Query: 930 GSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY 989
GS+A L C Q GM YLEE ++VHR+LAARNVL++ + +++D+G+A LL ++ +Y
Sbjct: 930 GSQAVL--CHQ---GMYYLEENKVVHRNLAARNVLLKNNYTAQVSDYGVADLLYRDDKKY 984
Query: 990 KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIEN 1049
K PIKW+ALE I R +TH+SDVW++GVT+WE++SYGA PY + +++ +L+E
Sbjct: 985 FFNEAKTPIKWMALESILFRKYTHQSDVWSYGVTVWEMMSYGAEPYNTMRPQDISDLLEK 1044
Query: 1050 GLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGD 1104
G +L QP ICT+D+Y VMV CWM+D + RPTFK+LA+ F MARDP RYLVI D
Sbjct: 1045 GERLSQPQICTIDVYMVMVKCWMVDENVRPTFKELANEFTRMARDPPRYLVIKED 1099
Score = 91.1 bits (216), Expect = 2e-16
Identities = 68/258 (26%), Positives = 107/258 (41%), Gaps = 36/258 (13%)
Query: 309 FKDCTIIDGSIEI------LEMTFT-GFQQVNQDYSFGERYPKMEPDALEVF-----STV 356
+ C I+ G++EI ++ +F G Q + + + P +++ ++
Sbjct: 27 YTGCEIVMGNLEITMMEHGMDFSFLKGDSQSQESTPLPPEHSCLRPRVIDLMCLLTRQSI 86
Query: 357 REVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVK------TXXXXXXXX 410
REVTGY+ + + F+ L NL VI G ++ EN +A + ++
Sbjct: 87 REVTGYILLAVN--TFSRLP-LDNLRVIRGNELYENQYALVVMINYPTKGGQGLQELGLT 143
Query: 411 XXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNLVCDPQCS 470
+ G + I +NR+L +A K+ W +VK I NG + C K C
Sbjct: 144 HLTEILQGGVKITQNRDLSFAPKVNWLDIVKDGTANITIFDNGPEKPCHK-------ACG 196
Query: 471 ADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCTGASRAN 530
CWGPG D C +C C+ + C CHSEC GCTG +
Sbjct: 197 DVPCWGPGSDMCQILTK----TVCAPQCNFR--CFGRSPGEC--CHSECAGGCTGPLDTD 248
Query: 531 CTSCKHVRDGPYCVAQCP 548
C +C+ D CV QCP
Sbjct: 249 CFACRKFNDSGSCVPQCP 266
Score = 79.0 bits (186), Expect = 9e-13
Identities = 48/110 (43%), Positives = 64/110 (58%), Gaps = 5/110 (4%)
Query: 766 VIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLR 825
VI+L+ S + VL ++ Y R A +K A++ M E EPL P K R
Sbjct: 717 VIVLLFVSFSVFVLTLL-YR-RGLAIRRKRAMRRYMERG--ESFEPLEPGE-KGAKVHAR 771
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
I+K +ELR +LG G FG VYKG+W+PEGE VK+PVAIKV+ + G T
Sbjct: 772 ILKPSELRTAKLLGNGVFGSVYKGIWIPEGETVKLPVAIKVIHDRPGQKT 821
Score = 53.6 bits (123), Expect = 4e-05
Identities = 54/204 (26%), Positives = 86/204 (42%), Gaps = 38/204 (18%)
Query: 16 DRFTNCTYVDGNLE--LTWLENESMD---------LSFLKYIREVTGYVLISHVKVHKI- 63
D F NCT + G+L LT + ++ + L +RE+T ++I +
Sbjct: 382 DSFINCTKIQGSLHFLLTGINGDNYNNVPPLDPEKLKIFNTVREITDMLVIQSWPTNMSD 441
Query: 64 --VLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFT-LELPALRDVLQGSVGIYSNFNLC 120
V LQ I+GR L+K ++L+V + + T L L +LR + G V I N NLC
Sbjct: 442 LSVFSNLQTIQGRKLYK------GYSLMVVKTPSLTSLGLRSLRKINDGGVYITGNKNLC 495
Query: 121 HVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKTICSPQ 180
+ T+NW T ++ + R + S +C + +C P
Sbjct: 496 YHDTVNW------------TLLLGSSSRQQRRHKNIDIKDNRPRS--DCVR-ENFVCDPL 540
Query: 181 CAQGRCFGPNPRDC--CNTFCAGG 202
C+ C+GP P C C + GG
Sbjct: 541 CSSDGCWGPGPSQCLSCKKYSRGG 564
Score = 43.6 bits (98), Expect = 0.039
Identities = 22/60 (36%), Positives = 27/60 (45%), Gaps = 11/60 (18%)
Query: 649 CQVCNGFKRGDQCEDECPSD---------HFTDEIGRNCTPCHSEC-KGCTGPGPTDCIK 698
C C + G C CP + D+ GR C PCH C KGC GPG DC++
Sbjct: 646 CLECANLQDGPHCVSSCPEGVMGGEEIIFKYPDKQGR-CEPCHGNCTKGCYGPGIRDCVE 704
Score = 43.2 bits (97), Expect = 0.052
Identities = 26/72 (36%), Positives = 31/72 (43%), Gaps = 8/72 (11%)
Query: 630 RKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECKG-C 688
+ CH C +G +CQ+ QC C F G C CHSEC G C
Sbjct: 189 KPCHKACGDVPCWGPGSDMCQILTKTVCAPQCNFRC----FGRSPGE-C--CHSECAGGC 241
Query: 689 TGPGPTDCIKCK 700
TGP TDC C+
Sbjct: 242 TGPLDTDCFACR 253
Score = 39.5 bits (88), Expect = 0.64
Identities = 25/73 (34%), Positives = 28/73 (38%), Gaps = 12/73 (16%)
Query: 632 CHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDEC-----PSDHFTDEIGRNCTPCHSECK 686
C PLC +G C C + RG C +C F G C PCH ECK
Sbjct: 537 CDPLCSSDGCWGPGPSQCLSCKKYSRGGICVADCMFLAGDRREFATASGE-CMPCHPECK 595
Query: 687 G------CTGPGP 693
CTGP P
Sbjct: 596 AQTGRETCTGPVP 608
Score = 38.3 bits (85), Expect = 1.5
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 7/61 (11%)
Query: 478 GPDQCLSCQNYNFGEICIDNC--SVHPG---LYKADHKS--CKQCHSECLDGCTGASRAN 530
G +CL C N G C+ +C V G ++K K C+ CH C GC G +
Sbjct: 642 GAAECLECANLQDGPHCVSSCPEGVMGGEEIIFKYPDKQGRCEPCHGNCTKGCYGPGIRD 701
Query: 531 C 531
C
Sbjct: 702 C 702
Score = 37.9 bits (84), Expect = 1.9
Identities = 29/112 (25%), Positives = 43/112 (38%), Gaps = 17/112 (15%)
Query: 444 DHKQIIQKNGDPRQCEKNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPG 503
D ++ +G+ C C Q + C GP PD N + C P
Sbjct: 576 DRREFATASGECMPCHPE---CKAQTGRETCTGPVPD-------LNQVQACCCPPEAAPS 625
Query: 504 LYKADHKSCKQCHSECLDGCTGASRANCTSCKHVRDGPYCVAQCPESRYASE 555
L + + S+ GA A C C +++DGP+CV+ CPE E
Sbjct: 626 LLRPRRADLLRFASQ-----QGA--AECLECANLQDGPHCVSSCPEGVMGGE 670
>UniRef50_Q6SAX5 Cluster: Epidermal growth factor receptor; n=14;
Drosophila melanogaster|Rep: Epidermal growth factor
receptor - Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 314 bits (772), Expect = 8e-84
Identities = 145/186 (77%), Positives = 171/186 (91%)
Query: 870 TTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKI 929
+TGA +S+EFL EAYIMASVEH NLL+LLAVCM++QMMLITQLMPLGCL+DYVR +++KI
Sbjct: 875 STGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKI 934
Query: 930 GSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY 989
GSKA LNW TQIA+GM+YLEEKRLVHRDLAARNVLVQTP+ VKITDFGLAKLL + +EY
Sbjct: 935 GSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEY 994
Query: 990 KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIEN 1049
KAAGGKMPIKWLALECI++R+FT KSDVWAFGVTIWE+L++G RP+ENI A+++P+LIE
Sbjct: 995 KAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEV 1054
Query: 1050 GLKLPQ 1055
GLKL Q
Sbjct: 1055 GLKLEQ 1060
Score = 194 bits (473), Expect = 1e-47
Identities = 82/181 (45%), Positives = 116/181 (64%)
Query: 332 VNQDYSFGERYPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVE 391
V +Y+ G RY ++P+ LEVFSTV+E+TGYLN++ HP F +LSYFRNLE I GRQ++E
Sbjct: 339 VYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLME 398
Query: 392 NLFASLYIVKTXXXXXXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQK 451
++FA+L IVK+ ++SG++ I NR+LCY I W + K + K + +
Sbjct: 399 SMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNE 458
Query: 452 NGDPRQCEKNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKS 511
N CEKN +C QC+ DGCWG G DQCL+C+N+NF CI +C YK D+++
Sbjct: 459 NLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRT 518
Query: 512 C 512
C
Sbjct: 519 C 519
Score = 117 bits (282), Expect = 2e-24
Identities = 52/90 (57%), Positives = 68/90 (75%)
Query: 52 YVLISHVKVHKIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSV 111
Y+LISHV V K+V P+LQIIRGRTLF L+V EE++AL VT S +TLE+P LRDVL G V
Sbjct: 59 YILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQV 118
Query: 112 GIYSNFNLCHVKTINWDEINQDLTQVTFTF 141
G ++N+NLCH++TI W EI + T + +
Sbjct: 119 GFHNNYNLCHMRTIQWSEIVSNGTDAYYNY 148
Score = 101 bits (241), Expect = 2e-19
Identities = 62/167 (37%), Positives = 83/167 (49%), Gaps = 13/167 (7%)
Query: 1230 SRYCSDPMKTRTEVSLEDNFDGMSKAKEAQVGNLKLNLPLDEDDYLMPSPQHTQNASTYM 1289
+RYC DP + +D D S A+E VGNL+L+LP+DEDDYLMP+ Q N + M
Sbjct: 1168 NRYCKDPSNKNSSTG-DDETD--SSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNM 1224
Query: 1290 DLISEGCEGQDVNDIRFGEFVSSKRCIDNPEYLMSEESVPPQTLGIPTEPVPXXXXXXXX 1349
+ ++ + + + +DNPEYL++ QTLG+ P+P
Sbjct: 1225 NNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNA-----QTLGVGESPIPTQTIGIPV 1279
Query: 1350 XXXDTTPRPGTSNYMPQRSVEEESMSDHEYYNDLQRELQPLRRNETT 1396
PGT E + SDHEYYND QRELQPL RN T
Sbjct: 1280 MGV-----PGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNT 1321
Score = 54.8 bits (126), Expect = 2e-05
Identities = 56/192 (29%), Positives = 83/192 (43%), Gaps = 47/192 (24%)
Query: 40 LSFLKYIREVTGYVLI--SHVKVHKI-VLPQLQIIRGRTLFKLNVREEEFALL-VTMSTA 95
L ++E+TGY+ I +H + + L+ I GR L E FA L + S+
Sbjct: 357 LEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLM-----ESMFAALAIVKSSL 411
Query: 96 FTLELPALRDVLQGSVGIYSNFNLCHVKTINWDEINQDLTQVTFTFIILPLGKGNARVVT 155
++LE+ L+ + GSV I N +LC+V I W I ++ Q + N R
Sbjct: 412 YSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWV-------NENLRA-- 462
Query: 156 QPARWAAGESIENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACR 215
+ C+K + TICS QC + C+G AG QCL C+
Sbjct: 463 -----------DLCEK-NGTICSDQCNEDGCWG-----------AG------TDQCLTCK 493
Query: 216 NFYDEGTCSQEC 227
NF GTC +C
Sbjct: 494 NFNFNGTCIADC 505
>UniRef50_UPI0000E47E88 Cluster: PREDICTED: similar to v-erb-a
erythroblastic leukemia viral oncogene homolog 4 isoform
JM-a/CVT-2 precursor; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to v-erb-a
erythroblastic leukemia viral oncogene homolog 4 isoform
JM-a/CVT-2 precursor - Strongylocentrotus purpuratus
Length = 1077
Score = 312 bits (766), Expect = 4e-83
Identities = 230/757 (30%), Positives = 332/757 (43%), Gaps = 85/757 (11%)
Query: 7 RDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKVHKIVLP 66
R +Y L+DR+TNCTYVDGNLE+++L + DL FL IREVTGY+LI I L
Sbjct: 53 RQQYYEELKDRYTNCTYVDGNLEISFLHEQEYDLGFLSSIREVTGYILILLTYSRVIPLT 112
Query: 67 QLQIIRGRTLFKLNVREEEFALLVTMS------TAFTLE--LPALRDVLQGSVGIYSNFN 118
L++IRG L+ ++++AL V ++ T T E L +L ++L+G V + N
Sbjct: 113 NLRVIRGTKLY-----DDKYALYVALTFHTGDPTIATEEMWLTSLHEILKGDVYFHQNNQ 167
Query: 119 LCHVKTINWDEINQDLT---QVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKT 175
LC+V+TI WD++ L + + W GE E+CQ +
Sbjct: 168 LCYVETIAWDDMQPGLVANISMWDEHAQRNCSEHRCHESCNGHCWGPGE--EHCQILTLK 225
Query: 176 ICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQIYNP 235
CS C RC GP DCC+ CAGGCT CLACR F + TC + CP Y+
Sbjct: 226 DCSSTCDY-RCRGPTQADCCHRSCAGGCTNSSNAGCLACRQFSLDNTCVETCPRRYEYDR 284
Query: 236 TTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAVNGECIPCVGTCPKTC 295
T++ NPN +Y+YG+ C+++CP ++L D CV+ C P K + +CIPC G CP TC
Sbjct: 285 NTFTNVENPNFRYSYGSRCLKDCPNNVLVDGDNCVKVCGPGKKEQDNQCIPCEGVCPSTC 344
Query: 296 RA---EKPIHSGNIDS--FKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDAL 350
+ + S +I S F +CT I+G++ I TFTG +F P ++P AL
Sbjct: 345 DGIGDDGALSSKHIRSKQFDNCTQINGNLIITSHTFTG-------DAFAGTTP-IDPSAL 396
Query: 351 EVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQ---VVENLFASLYIVKTXXXXX 407
E+F TV+++TGYL+VQ H +FT+LS F NLE I GR V + S+YI T
Sbjct: 397 EIFRTVKQITGYLSVQGLHQHFTNLSMFSNLERIDGRNLYGVGGSKTDSVYITSTNLDFF 456
Query: 408 XXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQC--------- 458
V++G I I N LCY K + + S IQ + C
Sbjct: 457 GLTSLAEVSNGDITISSNSKLCYLQKPMFRPIRSSNRQTISIQDSRSDADCQPPFASLAI 516
Query: 459 ------EKNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSC 512
E +L+ + G + + F + SV + D +C
Sbjct: 517 LDNQHLEALSLISLNELKLGGAYVQNNRLLCYSEETAFDAVINPEYSV-SFVNNKDRATC 575
Query: 513 ----KQCHSECLD-GCTGASRANCTSCKHVRDGPYCVAQCPESRYASEXXXXXXXXXXXX 567
K C +C D GC G C CK+ G C+ C
Sbjct: 576 IAENKTCDPQCADIGCWGPGPRQCAKCKNAIIGDTCIEACD----LDNGQYVETEASASE 631
Query: 568 XXXXXXANTVGEGGCN--SCNKAIISVEATVESCLKEDEPCPDGYYNEWVGNVKPLEGKV 625
+T GC+ ++ ++T +C + DG + +P
Sbjct: 632 AAVCEHCDTQCSAGCSGPEPDQCDCQSDSTGTNCRRMCRNVQDGPFCR-AECPEPKFANA 690
Query: 626 KIACRKCHPLCIK-CVG--FGIHEQVCQVC-----NGFKRGDQC---EDECPSDHFTDEI 674
+ C CH C+K C G + E C C + ++ +C C D+F D I
Sbjct: 691 QKNCTDCHSNCLKGCNGPENNLGEDGCLECPQVMLDYNRKVMECMLINTPCSDDYFYDRI 750
Query: 675 GRN-----------CTPCHSECKGCTGPGPTDCIKCK 700
+ C C C GC G GP C +CK
Sbjct: 751 SHSEKSDPLAGSVICQQCDPMCIGCDGAGPRRCKQCK 787
Score = 201 bits (491), Expect = 9e-50
Identities = 105/336 (31%), Positives = 165/336 (49%), Gaps = 34/336 (10%)
Query: 418 GAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNLVCDPQCSADGCWGP 477
G + NR LCY+++ A++ ++ + ++ N D C N CDPQC+ GCWGP
Sbjct: 536 GGAYVQNNRLLCYSEETAFDAVI-NPEYSVSFVNNKDRATCIAENKTCDPQCADIGCWGP 594
Query: 478 GPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKS------CKQCHSECLDGCTG------ 525
GP QC C+N G+ CI+ C + G Y S C+ C ++C GC+G
Sbjct: 595 GPRQCAKCKNAIIGDTCIEACDLDNGQYVETEASASEAAVCEHCDTQCSAGCSGPEPDQC 654
Query: 526 -----ASRANC-TSCKHVRDGPYCVAQCPESRYASEXXXXXXXXXXXXXXXXXXANTVGE 579
++ NC C++V+DGP+C A+CPE ++A+ N +GE
Sbjct: 655 DCQSDSTGTNCRRMCRNVQDGPFCRAECPEPKFANAQKNCTDCHSNCLKGCNGPENNLGE 714
Query: 580 GGCNSCNKAIISVEATVESCLKEDEPCPDGYYNEWVGNVK---PLEGKVKIACRKCHPLC 636
GC C + ++ V C+ + PC D Y+ + + + + PL G V C++C P+C
Sbjct: 715 DGCLECPQVMLDYNRKVMECMLINTPCSDDYFYDRISHSEKSDPLAGSV--ICQQCDPMC 772
Query: 637 IKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECKGCTGPGPTDC 696
I C G G + C+ C F++ D+C DEC S + D + C PCH +C+ C DC
Sbjct: 773 IGCDGAG--PRRCKQCKLFRQDDECVDECRSGFYPD-VDDMCQPCHPQCRQCFNGTVHDC 829
Query: 697 IKCKNLKIFLGGSDASDENAPFNCTDTCPDNIPNKI 732
+ C++ + G EN F C +CP PN++
Sbjct: 830 LDCESYTVQTG------ENT-FFCALSCPAEYPNEL 858
Score = 136 bits (330), Expect = 3e-30
Identities = 125/466 (26%), Positives = 192/466 (41%), Gaps = 84/466 (18%)
Query: 465 CDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNC-SVHPGLY-KAD---------HKSCK 513
CD QCSA GC GP PDQC CQ+ + G C C +V G + +A+ K+C
Sbjct: 638 CDTQCSA-GCSGPEPDQC-DCQSDSTGTNCRRMCRNVQDGPFCRAECPEPKFANAQKNCT 695
Query: 514 QCHSECLDGCTGASRA----NCTSCKHVR-DGPYCVAQCPESRYASEXXXXXXXXXXXXX 568
CHS CL GC G C C V D V +C
Sbjct: 696 DCHSNCLKGCNGPENNLGEDGCLECPQVMLDYNRKVMECMLINTPCSDDYFYDRISHSEK 755
Query: 569 XXXXXANTVGEGGCNSCNKAIISVEAT----VESC--LKEDEPCPDGYYNEWVGNVKPLE 622
+ + C C+ I + + C ++D+ C D + + +V +
Sbjct: 756 SDPLAGSVI----CQQCDPMCIGCDGAGPRRCKQCKLFRQDDECVDECRSGFYPDVDDM- 810
Query: 623 GKVKIACRKCHPLCIKCVGFGIHEQVCQVCNGF--KRGDQ---CEDECPSDH-------- 669
C+ CHP C +C +H+ C C + + G+ C CP+++
Sbjct: 811 ------CQPCHPQCRQCFNGTVHD--CLDCESYTVQTGENTFFCALSCPAEYPNELSPYV 862
Query: 670 --------FTDEIGRNCTPCHSECK-GCTGPGPTDCIKCKNLKIFLGGSDASDENAPFNC 720
F C CH+ECK GC + C CKN+ + L C
Sbjct: 863 CGKTCPTLFFPNAMSKCEGCHTECKDGCHNGTRSGCYACKNVVVNL------------EC 910
Query: 721 TDTCPDNIPNKIYFDEQLQDPIEEPYCSEHANDIPTATARTSTVLVIILVIASLFLAVLA 780
CP N + P + A P + I+ +F+ ++
Sbjct: 911 RAECPAAYKNTNGTCLYIHGP------DQKATPKPGGGMSIGLLAGIVTSSLIIFIVIIV 964
Query: 781 IIGYNFRQKAKAKKEAVKMTMV----LTGCE-DNEPLRPTNVKPNLAKLRIVKEAELRRG 835
+ + F+Q+ K + + C+ PL P+NV+PN A+L+I+K+ EL+ G
Sbjct: 965 FVIW-FKQRIKNDMYIDIPPNIDLHDMKSCDYTGAPLTPSNVEPNQAQLKIIKDTELKLG 1023
Query: 836 GMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLE 881
+LG GAFG VYKG+W+P+GE ++IPVAIK L+E + + ++E LE
Sbjct: 1024 PVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVS-PHAAEELLE 1068
Score = 35.9 bits (79), Expect = 7.9
Identities = 23/73 (31%), Positives = 30/73 (41%), Gaps = 7/73 (9%)
Query: 157 PARWAAGESIENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRN 216
PA + S C K T+ P A +C G C+T C GC + C AC+N
Sbjct: 851 PAEYPNELSPYVCGKTCPTLFFPN-AMSKCEG------CHTECKDGCHNGTRSGCYACKN 903
Query: 217 FYDEGTCSQECPS 229
C ECP+
Sbjct: 904 VVVNLECRAECPA 916
>UniRef50_Q26566 Cluster: Epidermal growth factor receptor precursor;
n=5; Schistosoma|Rep: Epidermal growth factor receptor
precursor - Schistosoma mansoni (Blood fluke)
Length = 1717
Score = 299 bits (735), Expect = 3e-79
Identities = 175/476 (36%), Positives = 269/476 (56%), Gaps = 56/476 (11%)
Query: 676 RNCTPCHSEC-KGCTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDNIPNKIYF 734
R C CH +C +GC+GPGP DC+KC+N +I L +E F C +CP++ N I+
Sbjct: 870 RRCLLCHEQCIQGCSGPGPEDCVKCRNYQIIL-----DEETNKFVCNSSCPED-RNHIFH 923
Query: 735 DEQLQDPIEEPYCSEHANDIPTATARTSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKK 794
L + A ++ +V V I++ + V+ + ++KA+A+K
Sbjct: 924 GMCLTAEQNARLSGQTARELRNRILIGVSVSVFIIIALVTIILVVCL-----KRKAEAEK 978
Query: 795 EAVKMTMVLTG-CEDNEPLRPTNVKPNLAKLRIVKEAEL---RRGGMLGFGAFGKVYKGV 850
++ T E + + + +PN+ +L ++ + +L LG G+FG VYKGV
Sbjct: 979 IREQLRSAYTNLLEPDMKTQSVSREPNMGRLEMINQDDLFCDFNSAPLGTGSFGAVYKGV 1038
Query: 851 W-VPE--------GENVKIPVAIKVLKE-----TTGANTSKEF----------------- 879
W VP+ ++ VAIKV+ + AN S F
Sbjct: 1039 WKVPKHALLRYNWHRGAQLDVAIKVILNDSPECSVTANPSSPFEAGNSSYSEEEAKRASV 1098
Query: 880 ---LEE----AYIMASVEHPNLLQLLAVCMTNQM-MLITQLMPLGCLVDYVRTHKEKIGS 931
+EE A IMASV H + L L+ +C++++ L++ + LG L YV+ H +++ S
Sbjct: 1099 RANIEELLQEAKIMASVMHRHCLPLIGICLSSERHCLVSIFVELGALDRYVKQHADELNS 1158
Query: 932 KAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLD-INEDEYK 990
L+W QIA GM+YLE + ++HRDLAARNVLVQT V+ITDFGLAK+L+ +ED
Sbjct: 1159 LTLLSWAEQIADGMSYLEMRGIIHRDLAARNVLVQTREHVQITDFGLAKMLERRDEDSVI 1218
Query: 991 AAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENG 1050
G++PI+WLA+E +Q+ I++HK+DVW++GVT+WEI ++G RPYE++ ++ + + G
Sbjct: 1219 VKAGRVPIRWLAIETLQYGIYSHKTDVWSYGVTLWEIFTFGKRPYEDVDTVDIKDHVIKG 1278
Query: 1051 LKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKF 1106
+L QP ICTLD+Y V+V CWM D +SRPTF +L TF + PGRYL I GD++
Sbjct: 1279 GRLTQPDICTLDVYMVLVKCWMEDYESRPTFIELMRTFNTFCKTPGRYLYIEGDQY 1334
Score = 156 bits (379), Expect = 4e-36
Identities = 131/541 (24%), Positives = 232/541 (42%), Gaps = 53/541 (9%)
Query: 2 SVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLEN----ESMDLSFLKYIREVTGYVLISH 57
S P+ + ++ + CT++ GNL + LE DLSFL+ I +V+GYV I
Sbjct: 40 SKPNPKHIQLTYIKFLYGGCTHIIGNLVICGLEKLENGSDPDLSFLEKIEDVSGYVYIGQ 99
Query: 58 VKVHKIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSVGIYSNF 117
V I LP L++IRG ++ + AL+++ ++ L+L +L + + + +N
Sbjct: 100 NSVKTISLPSLKVIRGEPGYR--IMNTSAALVISRNSLEILDLRSLTAIQRNDIVALNNQ 157
Query: 118 NLCHVK-TINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQKFSKTI 176
LC+ TI+W++I +D + F +A ++ + +C
Sbjct: 158 FLCNFGFTIDWEQIFEDNRKQMFIPDRKEKTVSHAGCDIALRKYTDDRTKHSCHGS---- 213
Query: 177 CSPQCAQGRCFGPNPRDC-----C----NTFCAGG----------CTGPLPTQ---CLAC 214
C +G C+GP P C C + +C GG C G T+ C AC
Sbjct: 214 CPVVNGRGYCWGPKPEMCQKMLKCANNPDNYCLGGRATTQPCLEECLGGCETRPGNCRAC 273
Query: 215 RNFYDEGTCSQECPSMQIYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCP 274
++ ++G C +CP I + NP KY + CV+NCP LK + CV C
Sbjct: 274 KHAMNDGKCVSQCPPPLIVSREESRTVANPEFKYNFHDICVKNCPAPFLKSDSYCVIECD 333
Query: 275 PN-KTAVNGECIPCVGT-CPKTCRAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQV 332
N + VNG C C + CP+ C+ E +G+++ + ++ + +TG +
Sbjct: 334 LNTQIPVNGTCKDCPKSGCPEHCKEETIFVNGSLNILQSSSLRKFKSCVY---YTGGLYI 390
Query: 333 NQD-YSFGERYPKMEPDALEVFST--VREVTGYL--NVQAHHPNFTSLSYFRNLEVIGGR 387
+++ + +P + E+++ ++ + GY+ +++ +L++ NLE +
Sbjct: 391 SKESFQKSSLFPDPIQNVNELYNLLHLKSIVGYIYFDLREAPEELKNLTFLENLESV-VL 449
Query: 388 QVVENLFASLYIVKTXXXXXXXXXXXXVNSGAIAIMENR-NLCYADKIAWNKLVKSKDHK 446
+V ++ + N G ++N LCY + V+ D
Sbjct: 450 EVKSQSPGAVITIMNGENIESFGFKSLTNIGGYVYLKNMPKLCYISALTKMLPVRMID-- 507
Query: 447 QIIQKNGDPRQCEKNNLVCDPQCSAD-GCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLY 505
+Q D C K VC +C + GCWG + C C GE C+ C+ HPG Y
Sbjct: 508 --VQ---DEELCAKRGHVCHSECLPELGCWGADANMCAHCCGLKAGEYCVSRCTDHPGFY 562
Query: 506 K 506
+
Sbjct: 563 E 563
Score = 70.9 bits (166), Expect = 2e-10
Identities = 47/185 (25%), Positives = 67/185 (36%), Gaps = 31/185 (16%)
Query: 510 KSCKQCHSECLDGCTGASRANCTS-CKHVRDGPYCVAQCPESRYASEXXX---------X 559
K+C CH EC C G + C CKH + G C+ +CP + Y
Sbjct: 608 KTCAICHPECAQTCYGPNANQCVGECKHYQHGDTCLPECPRNTYIDPQTRHCLPCNESCS 667
Query: 560 XXXXXXXXXXXXXXANTVGEGGCNSCNKAIISVEATVESCLKEDEPCPDGYYNE------ 613
N +G GGC +C I CL +D CP +Y E
Sbjct: 668 HILTTGQNQLCSGPGNFLGLGGCETCWTVIQDKITNKYQCLPDD--CPPKHYTESYQTQD 725
Query: 614 WVGNVK------------PLEGKVKIACRKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQC 661
++ K L G +++ C+ CHP C C G H +C C + +C
Sbjct: 726 FINKEKIIVSSHSQVKKGELGGMIRV-CKPCHPFCDLCTANGTHASICHSCTHWWFKSEC 784
Query: 662 EDECP 666
+ CP
Sbjct: 785 VEICP 789
Score = 54.0 bits (124), Expect = 3e-05
Identities = 35/121 (28%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 629 CRKCHPLCIK-CVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECKG 687
C CHP C + C G ++ V + C ++ GD C ECP + + D R+C PC+ C
Sbjct: 610 CAICHPECAQTCYGPNANQCVGE-CKHYQHGDTCLPECPRNTYIDPQTRHCLPCNESCSH 668
Query: 688 CTGPGPTDCIKCKNLKIFLGGSDAS---DENAPFNCTDTCPDNIPNKIYFDE-QLQDPIE 743
G + LGG + ++ N PD+ P K Y + Q QD I
Sbjct: 669 ILTTGQNQLCSGPGNFLGLGGCETCWTVIQDKITNKYQCLPDDCPPKHYTESYQTQDFIN 728
Query: 744 E 744
+
Sbjct: 729 K 729
Score = 53.6 bits (123), Expect = 4e-05
Identities = 51/222 (22%), Positives = 85/222 (38%), Gaps = 32/222 (14%)
Query: 346 EPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXX 405
+PD L + +V+GY+ + + SL + + G +++ N A+L I +
Sbjct: 79 DPD-LSFLEKIEDVSGYVYIGQNSVKTISLPSLKVIRGEPGYRIM-NTSAALVISRNSLE 136
Query: 406 XXXXXXXXXVNSGAIAIMENRNLC-YADKIAWNKLVKSKDHKQII----QKNGDPRQCE- 459
+ I + N+ LC + I W ++ + + I +K C+
Sbjct: 137 ILDLRSLTAIQRNDIVALNNQFLCNFGFTIDWEQIFEDNRKQMFIPDRKEKTVSHAGCDI 196
Query: 460 --------KNNLVCDPQCSA-DG---CWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKA 507
+ C C +G CWGP P+ C C+ +P Y
Sbjct: 197 ALRKYTDDRTKHSCHGSCPVVNGRGYCWGPKPEMCQKMLK----------CANNPDNYCL 246
Query: 508 DHKSCKQ-CHSECLDGCTGASRANCTSCKHVRDGPYCVAQCP 548
++ Q C ECL GC NC +CKH + CV+QCP
Sbjct: 247 GGRATTQPCLEECLGGCE-TRPGNCRACKHAMNDGKCVSQCP 287
Score = 44.0 bits (99), Expect = 0.030
Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 3/74 (4%)
Query: 460 KNNLVCDPQCSADGCWGPGPDQCL-SCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSE 518
K +C P+C A C+GP +QC+ C++Y G+ C+ C + + + C C+
Sbjct: 608 KTCAICHPEC-AQTCYGPNANQCVGECKHYQHGDTCLPECPRNTYI-DPQTRHCLPCNES 665
Query: 519 CLDGCTGASRANCT 532
C T C+
Sbjct: 666 CSHILTTGQNQLCS 679
Score = 41.5 bits (93), Expect = 0.16
Identities = 17/37 (45%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 515 CHSECLD--GCTGASRANCTSCKHVRDGPYCVAQCPE 549
CHSECL GC GA C C ++ G YCV++C +
Sbjct: 521 CHSECLPELGCWGADANMCAHCCGLKAGEYCVSRCTD 557
Score = 40.3 bits (90), Expect = 0.37
Identities = 14/33 (42%), Positives = 22/33 (66%), Gaps = 1/33 (3%)
Query: 456 RQCEKNNLVCDPQCSADGCWGPGPDQCLSCQNY 488
++ ++ L+C QC GC GPGP+ C+ C+NY
Sbjct: 866 KRTQRRCLLCHEQC-IQGCSGPGPEDCVKCRNY 897
Score = 37.5 bits (83), Expect = 2.6
Identities = 16/44 (36%), Positives = 22/44 (50%), Gaps = 1/44 (2%)
Query: 195 CNTFCAGGCTGPLPTQCLA-CRNFYDEGTCSQECPSMQIYNPTT 237
C+ CA C GP QC+ C+++ TC ECP +P T
Sbjct: 613 CHPECAQTCYGPNANQCVGECKHYQHGDTCLPECPRNTYIDPQT 656
Score = 37.5 bits (83), Expect = 2.6
Identities = 15/53 (28%), Positives = 25/53 (47%), Gaps = 7/53 (13%)
Query: 506 KADHKSCKQCHSECLDGCTGASRANCTSCKHVR-------DGPYCVAQCPESR 551
K + C CH +C+ GC+G +C C++ + + C + CPE R
Sbjct: 866 KRTQRRCLLCHEQCIQGCSGPGPEDCVKCRNYQIILDEETNKFVCNSSCPEDR 918
Score = 37.1 bits (82), Expect = 3.4
Identities = 17/41 (41%), Positives = 22/41 (53%), Gaps = 7/41 (17%)
Query: 195 CNTFCAGGCTGPLPTQCLACRNF---YDEGT----CSQECP 228
C+ C GC+GP P C+ CRN+ DE T C+ CP
Sbjct: 875 CHEQCIQGCSGPGPEDCVKCRNYQIILDEETNKFVCNSSCP 915
>UniRef50_Q5BXN9 Cluster: SJCHGC05493 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC05493 protein - Schistosoma
japonicum (Blood fluke)
Length = 418
Score = 283 bits (694), Expect = 2e-74
Identities = 123/228 (53%), Positives = 174/228 (76%)
Query: 857 NVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLG 916
N+ IPVAIKVL ++ T+KE LEEA +MA+V+HP ++ LA+C+T+++ LITQ +PLG
Sbjct: 190 NLNIPVAIKVLSDSADPQTNKELLEEAKVMATVDHPCCVRFLALCLTSKLQLITQFLPLG 249
Query: 917 CLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDF 976
L+++V+ + I + W QIA GMAYL + ++HRDLAARNVLVQ+ + VKITDF
Sbjct: 250 SLLEFVKIRWDVIEINSLFQWSEQIASGMAYLSSRGIIHRDLAARNVLVQSKDQVKITDF 309
Query: 977 GLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYE 1036
GLAK LD + +EY A+GG+MPIKWLA+E IQ RIF++KSDVWA+G+T+WE+ ++G RPYE
Sbjct: 310 GLAKCLDTSHNEYHASGGRMPIKWLAIESIQERIFSYKSDVWAYGITLWEMCTFGHRPYE 369
Query: 1037 NISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
NI A+++ + +E G +LPQP +L+ YC+M+ CW D + RPTFK+L
Sbjct: 370 NIHAKDLLDYLEKGNRLPQPETTSLEFYCLMLQCWHTDPNLRPTFKEL 417
Score = 56.0 bits (129), Expect = 7e-06
Identities = 25/48 (52%), Positives = 34/48 (70%)
Query: 807 EDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPE 854
E+ P ++KPN+A LRI+ E+EL RG ++G GAFG VY GVW P+
Sbjct: 87 ENITPTCSDSLKPNMATLRIITESELIRGPLIGSGAFGTVYCGVWCPK 134
>UniRef50_Q4SMB8 Cluster: Chromosome 3 SCAF14553, whole genome shotgun
sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 3
SCAF14553, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 606
Score = 280 bits (686), Expect = 2e-73
Identities = 125/204 (61%), Positives = 162/204 (79%), Gaps = 4/204 (1%)
Query: 941 IARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKW 1000
++ GM YLEE+RLVHRDLAARNVLV++PN +KITDFGLA+LLD NE EY A GGKMPIKW
Sbjct: 1 MSEGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDANEKEYNADGGKMPIKW 60
Query: 1001 LALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICT 1060
+ALECI +R FTH+SDVW++GVTIWE++++G +PY+ I R +P+++E G +LPQP ICT
Sbjct: 61 MALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICT 120
Query: 1061 LDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEM 1120
+D+Y VMV CWM+DADSRP FK+LA F MARDP RYLVI GD M+LPS ++ +
Sbjct: 121 IDVYMVMVKCWMIDADSRPKFKELAAEFCRMARDPQRYLVIQGDDRMKLPS---PNDSKF 177
Query: 1121 IRNLSSAMEGPESLVDADEYLQPK 1144
++L E ++L+DADEYL P+
Sbjct: 178 FQSLLDE-EDLDNLMDADEYLVPQ 200
>UniRef50_Q4RW26 Cluster: Chromosome 9 SCAF14991, whole genome shotgun
sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 9
SCAF14991, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1344
Score = 274 bits (672), Expect = 1e-71
Identities = 167/491 (34%), Positives = 246/491 (50%), Gaps = 64/491 (13%)
Query: 630 RKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPS-DHFTDEIGR---NCTPCHSEC 685
R C PLC +G C C + R C +C F+ E C CH EC
Sbjct: 513 RVCDPLCSDSGCWGPGPDQCLSCRKYSRHGTCVADCFFYSGFSREFAALDGECVACHPEC 572
Query: 686 K------GCTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDNI----------- 728
K CTGPG C++C N ++ P+ C +CP+ +
Sbjct: 573 KPQTGRVSCTGPGADKCVECTNF-----------QDGPY-CMPSCPNGVNDGQRGLIFKF 620
Query: 729 PNKIYFDEQLQDPIEEPYCSEHANDIPTATARTSTVLVIILVIASLFLAVLAIIGYNFRQ 788
PN+ E + ND A + T + + + +F VL +G + +
Sbjct: 621 PNREGHCEPCHQNCTQGCSGPGLNDCLEAASGQITGIALGVPAGLIFCLVLFFLGMLYHR 680
Query: 789 KAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYK 848
+++ M L E EPL P K R++K +ELR+ LG G FG V K
Sbjct: 681 GLAIRRKRA-MRRYLESGESFEPLGPGE-KGTKVYARVLKPSELRKIKSLGSGVFGTVNK 738
Query: 849 GVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMML 908
G W PEGE VKIPVAIK +++++G T E + M S++HP +++LL +C + L
Sbjct: 739 GFWTPEGETVKIPVAIKTIQDSSGRRTFTEITDHMLSMGSLDHPYIVRLLGICPGPSLQL 798
Query: 909 ITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTP 968
+TQL G L++++R HK + + LNWC QIA+GM YLEE R+VHR+LAARN+L++
Sbjct: 799 VTQLSSHGSLLEHIRQHKTSLDPQRLLNWCVQIAKGMYYLEEHRMVHRNLAARNILLKND 858
Query: 969 NSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFG------- 1021
V+I+D+G+A LL ++ +Y K PIKW+ALE I R ++H+SDVW++G
Sbjct: 859 YQVQISDYGVADLLYPDDKKYIYTETKTPIKWMALESILFRRYSHQSDVWSYGEKCVCVC 918
Query: 1022 --VTIW--------------------EILSYGARPYENISARNVPELIENGLKLPQPSIC 1059
V +W E++S+GA PY ++ + VP L+E G +L QP IC
Sbjct: 919 VCVCVWPCAVCLKAVVNFLRTGVTVWEMMSFGAEPYASVQPQEVPSLLEKGERLSQPPIC 978
Query: 1060 TLDIYCVMVSC 1070
T+D+Y VMV C
Sbjct: 979 TIDVYMVMVKC 989
Score = 254 bits (623), Expect = 1e-65
Identities = 158/422 (37%), Positives = 213/422 (50%), Gaps = 49/422 (11%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+S +++ Y +DR+ C + GNLE+T +E++ D SFLK IREVTGYVLI+
Sbjct: 9 LSSTGSQENQYNLTKDRYNGCEIIMGNLEITQIESD-WDFSFLKTIREVTGYVLIAMNHF 67
Query: 61 HKIVLPQLQIIRGRTLFKLNVREEEFALLVTM-------STAFTLELPALRDVLQGSVGI 113
+I L QL++IRG +L+ E FAL V + S L L L ++L G V I
Sbjct: 68 QEIPLEQLRVIRGNSLY-----ERRFALSVFLNYPKDGSSGMNRLSLMNLTEILDGGVQI 122
Query: 114 YSNFNLCHVKTINWDEI--NQDLT-QVTFT------------FIILPLGKGNARVVTQPA 158
+N L + + W +I N D ++ F + P K ++ +P
Sbjct: 123 INNKYLRYGPWVYWQDIIRNNDAPIEIQFNGARGGCHKSCGDYCWGP-DKDQCQICERPV 181
Query: 159 RWAAGESIENCQKFS--KTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRN 216
+ S + KT+C+PQC RCFG +PRDCC+ CA GC GPL T C ACR+
Sbjct: 182 LPSQFPSFSQHGSITMTKTVCAPQC-NDRCFGTSPRDCCHVECAAGCKGPLDTDCFACRH 240
Query: 217 FYDEGTCSQECPSMQIYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPN 276
F D G C +CP IYN T+ E NPN KY YG+ CV CP H + D +CV CPP
Sbjct: 241 FNDSGACVPQCPLTLIYNKQTFQMETNPNAKYQYGSICVSQCPTHFVVDGRSCVSVCPPG 300
Query: 277 KTAV----NGECIPCVGTCPKTCRA-----EKPIHSGNIDSFKDCTIIDGSIEILEMTFT 327
KT V +C C G CPK C + + S NIDSF +CT I GS+ L
Sbjct: 301 KTEVERGGQRQCELCSGLCPKVCEGTGAEHRQTVDSSNIDSFVNCTKIQGSLHFLVTGIL 360
Query: 328 GFQQVNQDYSFGERYPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGR 387
G + N P ++ LEVF TVRE+T LN+Q+ LS F +L I GR
Sbjct: 361 GDEFKN--------VPPLDAKKLEVFRTVREITDILNIQSWPRQLNDLSVFSSLTTIQGR 412
Query: 388 QV 389
+
Sbjct: 413 SL 414
Score = 122 bits (294), Expect = 7e-26
Identities = 53/143 (37%), Positives = 73/143 (51%), Gaps = 9/143 (6%)
Query: 415 VNSGAIAIMENRNLCYADKIAWNKLVKS-KDHKQIIQKNGDPRQCEKNNLVCDPQCSADG 473
++ G++ I +N NLCY + W +L + +D + N C + VCDP CS G
Sbjct: 464 ISDGSVYISQNANLCYHHTVNWTQLFRGGRDRANSLSSNRPLTDCVADGRVCDPLCSDSG 523
Query: 474 CWGPGPDQCLSCQNYNFGEICIDNCSVHPGL---YKADHKSCKQCHSECLD-----GCTG 525
CWGPGPDQCLSC+ Y+ C+ +C + G + A C CH EC CTG
Sbjct: 524 CWGPGPDQCLSCRKYSRHGTCVADCFFYSGFSREFAALDGECVACHPECKPQTGRVSCTG 583
Query: 526 ASRANCTSCKHVRDGPYCVAQCP 548
C C + +DGPYC+ CP
Sbjct: 584 PGADKCVECTNFQDGPYCMPSCP 606
Score = 80.6 bits (190), Expect = 3e-13
Identities = 62/216 (28%), Positives = 90/216 (41%), Gaps = 37/216 (17%)
Query: 355 TVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFA-SLYIVKTXXXXXXXXXXX 413
T+REVTGY+ + +H F + L VI G + E FA S+++
Sbjct: 52 TIREVTGYVLIAMNH--FQEIP-LEQLRVIRGNSLYERRFALSVFLNYPKDGSSGMNRLS 108
Query: 414 XVN-----SGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNLVCDPQ 468
+N G + I+ N+ L Y + W ++++ D IQ NG C K+ C
Sbjct: 109 LMNLTEILDGGVQIINNKYLRYGPWVYWQDIIRNNDAPIEIQFNGARGGCHKS---C--- 162
Query: 469 CSADGCWGPGPDQCLSC-------QNYNFGE---------ICIDNCSVHPGLYKADHKSC 512
D CWGP DQC C Q +F + +C C + + + C
Sbjct: 163 --GDYCWGPDKDQCQICERPVLPSQFPSFSQHGSITMTKTVCAPQC--NDRCFGTSPRDC 218
Query: 513 KQCHSECLDGCTGASRANCTSCKHVRDGPYCVAQCP 548
CH EC GC G +C +C+H D CV QCP
Sbjct: 219 --CHVECAAGCKGPLDTDCFACRHFNDSGACVPQCP 252
Score = 57.6 bits (133), Expect = 2e-06
Identities = 26/83 (31%), Positives = 41/83 (49%), Gaps = 8/83 (9%)
Query: 457 QCEKNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNC--SVHPG----LYKADHK 510
+C + C PQ C GPG D+C+ C N+ G C+ +C V+ G ++K ++
Sbjct: 564 ECVACHPECKPQTGRVSCTGPGADKCVECTNFQDGPYCMPSCPNGVNDGQRGLIFKFPNR 623
Query: 511 S--CKQCHSECLDGCTGASRANC 531
C+ CH C GC+G +C
Sbjct: 624 EGHCEPCHQNCTQGCSGPGLNDC 646
Score = 54.0 bits (124), Expect = 3e-05
Identities = 55/213 (25%), Positives = 86/213 (40%), Gaps = 26/213 (12%)
Query: 39 DLSFLKYIREVTGYVLISHVKVHKIVLPQLQIIRGRTLFKLNVREEEFALLVT-MSTAFT 97
DLS + + G L +V + V P+ + + F+L+V + T +
Sbjct: 399 DLSVFSSLTTIQGRSLHKYVSRVRSVTPR---VPSHANAPVCAPSRRFSLMVMRIPTLTS 455
Query: 98 LELPALRDVLQGSVGIYSNFNLCHVKTINW--------DEINQDLTQVTFTFIILPLGKG 149
L L +LR++ GSV I N NLC+ T+NW D N + T + G+
Sbjct: 456 LGLRSLREISDGSVYISQNANLCYHHTVNWTQLFRGGRDRANSLSSNRPLTDCVAD-GRV 514
Query: 150 NARVVTQPARWAAG-ESIENCQKFSK-TICSPQC----AQGRCFGPNPRDC--CNTFCAG 201
+ + W G + +C+K+S+ C C R F +C C+ C
Sbjct: 515 CDPLCSDSGCWGPGPDQCLSCRKYSRHGTCVADCFFYSGFSREFAALDGECVACHPECKP 574
Query: 202 -----GCTGPLPTQCLACRNFYDEGTCSQECPS 229
CTGP +C+ C NF D C CP+
Sbjct: 575 QTGRVSCTGPGADKCVECTNFQDGPYCMPSCPN 607
Score = 50.8 bits (116), Expect = 3e-04
Identities = 29/92 (31%), Positives = 41/92 (44%), Gaps = 18/92 (19%)
Query: 629 CRKCHPLC------IKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIG------- 675
C CHP C + C G G + C C F+ G C CP+ + G
Sbjct: 565 CVACHPECKPQTGRVSCTGPGADK--CVECTNFQDGPYCMPSCPNGVNDGQRGLIFKFPN 622
Query: 676 --RNCTPCHSEC-KGCTGPGPTDCIKCKNLKI 704
+C PCH C +GC+GPG DC++ + +I
Sbjct: 623 REGHCEPCHQNCTQGCSGPGLNDCLEAASGQI 654
Score = 35.9 bits (79), Expect = 7.9
Identities = 23/87 (26%), Positives = 39/87 (44%), Gaps = 4/87 (4%)
Query: 465 CDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCT 524
C +C+A GC GP C +C+++N C+ C + K + +++ G
Sbjct: 219 CHVECAA-GCKGPLDTDCFACRHFNDSGACVPQCPLTLIYNKQTFQMETNPNAKYQYGSI 277
Query: 525 GASRANCTSCKHVRDGPYCVAQCPESR 551
S+ C + V DG CV+ CP +
Sbjct: 278 CVSQ--CPT-HFVVDGRSCVSVCPPGK 301
>UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus
multilocularis|Rep: EGF receptor - Echinococcus
multilocularis
Length = 1564
Score = 259 bits (634), Expect = 4e-67
Identities = 117/232 (50%), Positives = 165/232 (71%), Gaps = 2/232 (0%)
Query: 877 KEFLEEAYIMASVEHPNLLQLLAVCMTNQMM-LITQLMPLGCLVDYVRTHKEKIGSKAFL 935
++ L EA +MASV+H N L L+ VC+T +M +++ + G L Y+R H++ + S L
Sbjct: 1060 QDMLTEAKVMASVQHKNCLPLIGVCLTRKMQCMVSMFVEEGSLDRYLRLHRDDLNSFTLL 1119
Query: 936 NWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDIN-EDEYKAAGG 994
+W QIA GMAYLEE+ ++HRDLAARNVLVQ+ V+ITDFGLAK+LD N ED G
Sbjct: 1120 SWAEQIADGMAYLEERGIIHRDLAARNVLVQSRELVQITDFGLAKMLDTNNEDSVVVRTG 1179
Query: 995 KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLP 1054
++PI+WLA+E +Q I++HK+DVW++GVT+WEI ++G +PYENIS + + + G++L
Sbjct: 1180 RVPIRWLAIETLQAGIYSHKTDVWSYGVTLWEIFTFGKQPYENISTSEIKDHVMKGVRLS 1239
Query: 1055 QPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKF 1106
QP ICTLD Y VMV CWM + +SRPTF +L F + + PGRYL I GD++
Sbjct: 1240 QPEICTLDTYMVMVQCWMEEHESRPTFLELMKCFHKYCQTPGRYLYIEGDEY 1291
Score = 170 bits (414), Expect = 2e-40
Identities = 155/536 (28%), Positives = 234/536 (43%), Gaps = 49/536 (9%)
Query: 6 NRDTHYRNLRDRFTNCTYVDGNLELTWL----ENESMDLSFLKYIREVTGYVLISHVKVH 61
N T + +++ CT++ GNL L L + DLSFL IREV+GYV I + +V
Sbjct: 47 NAKTLLAYYKRQYSQCTHIIGNLVLCNLKRLEDGSDPDLSFLNSIREVSGYVYIGNNEVK 106
Query: 62 KIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTA-FT-----LELPALRDVLQGSVGIYS 115
+I L L+IIRGR + + + AL+VT + +T L+L +L + + ++ +
Sbjct: 107 RIPLISLRIIRGRVPYHVG-NVGDGALIVTRNAKNYTHGLEVLDLRSLAVIQEHNIIAWD 165
Query: 116 NFNLCHVK-TINWDEINQDLT---QVTFTFIILPLGKGNARVVTQPARW------AAGES 165
N LCH + T++ ++ D+ +++ + L G G P R A E+
Sbjct: 166 NPMLCHFQYTVDCPQLFVDVKNQRRLSVSKENLISGSGCDYDTDSPMRRNTTCHSACSEN 225
Query: 166 IE--NCQKFSKTICS--PQCAQGR---CFGPNP--RDCCNTFCAGGCTGPLPTQCLACRN 216
E +C K C +C + C NP R C+ C GGC G + C ACR+
Sbjct: 226 DEKGHCWGPEKNQCQLRSKCTKESTTYCRLDNPFERIKCDDACIGGCNGST-SNCWACRS 284
Query: 217 FYDEGTCSQECPSMQIYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPN 276
+ TC CP NPTT E NP+ KY CVR CPE LLK + CV C
Sbjct: 285 KRNGDTCVSFCPPRHHVNPTTSRQELNPDFKYELHDICVRQCPEPLLKMDTVCVIECDFK 344
Query: 277 KT-AVNGECIPCVGT-CPKTCRAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQ 334
T VNG C+PC T C C +K I S + ++G +N+
Sbjct: 345 TTIPVNGSCVPCAKTPCANHCE-QKDIFGSRFPLMTSAAAKRMSQCVF---YSGAIYINK 400
Query: 335 D-YSFGERYPKMEPDALEVFSTVREVTG--YLNVQAHHPNFTSLSYFRNL-EVIGGRQVV 390
D + + P ++ + L +RE+ G YL++ A P +L++ NL +V
Sbjct: 401 DSFKVTLKRPGLQIEDLWNLHNIREIVGYIYLDLDASSPELRNLTFLENLYKVTTEFSDG 460
Query: 391 ENLFASLYIVKTXXXXXXXXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQ 450
+L L I + + +LCY + V++K K
Sbjct: 461 VSLDQPLVIYHSKYLEFLGLKSLRYMDMTAYLEALPSLCYTSALEKILPVRTKGVK---- 516
Query: 451 KNGDPRQCEKNNLVCDPQCSAD-GCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLY 505
DP C + VC +C + GCWGPGP C C + +C+ +CS PG Y
Sbjct: 517 ---DPATCIREGHVCHSECLPEAGCWGPGPAMCAHCCTFEANGVCVSDCSEAPGFY 569
Score = 125 bits (302), Expect = 7e-27
Identities = 114/415 (27%), Positives = 167/415 (40%), Gaps = 71/415 (17%)
Query: 512 CKQCHSECLDGCTGASRANCTS-CKHVRDGPYCVAQCPESRYASE-------------XX 557
C +CH EC + CT C CKH + G CV +C + +YA E
Sbjct: 613 CARCHEECAESCTAPGPDQCLGECKHFKSGDTCVKRCSKEQYAEEKQKLCQPCNSKCLAS 672
Query: 558 XXXXXXXXXXXXXXXXANTVGEGGCNSCNKAIISVEATVESCLKEDEPCPDGYYNEWVG- 616
+ +G GGC C + CL D CP ++
Sbjct: 673 LKSKFPPDDISACSGPGDYLGLGGCAFCYFVKKDKATSKYQCL--DMKCPPKHFGNATSL 730
Query: 617 ---NVKPLEG---KVKIA------CRKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDE 664
N+K E V+ A C CHP C CVG G H VC+ C + +C +
Sbjct: 731 THLNLKKEEFPLVSVRAANADLQECVPCHPECEVCVGPGNHVSVCRKCRNWMYRSECVNA 790
Query: 665 CPSDHF-------TDEIG---------RNCTPCHSECKG-CTGPGPTDCIKCKNLKIFLG 707
CP D T+ + R C CH +C G CT GP C C+ KI +
Sbjct: 791 CPPDDTYVPNATATEHLSEREKQMLERRECLRCHEQCAGGCTAYGPEFCNNCRYAKIMI- 849
Query: 708 GSDASDENAPFNCTDTCPDNIPNKIYFDEQLQDPIEEPYCSEHANDIPTATARTSTVLV- 766
D F C TCP + K+ D EE Y E + A AR ++
Sbjct: 850 --DVQANK--FICNSTCPPEL-YKMENTNLCLD--EEQY--EKMSGAKLARARNQALIAA 900
Query: 767 -IILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLR 825
I+L+ +F VL+++ +N++ K KEA+K T T D + + + +PN+ +
Sbjct: 901 GIVLLFLLIFSLVLSVLCFNYKAKRSRIKEALKSTYTNTKAPDMKDAKSSR-EPNMGRWE 959
Query: 826 IVKEAELR---RGGMLGFGAFGKVYKGVW-VPE--------GENVKIPVAIKVLK 868
++ +L +G GAFG+VY+G W VP+ N + VAIKV++
Sbjct: 960 MINIDDLTFDDANNPIGRGAFGEVYRGKWRVPKRVLNQFNWARNTSLDVAIKVIR 1014
Score = 51.6 bits (118), Expect = 1e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 3/57 (5%)
Query: 465 CDPQCSADGCWGPGPDQCL-SCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECL 520
C +C A+ C PGPDQCL C+++ G+ C+ CS + K C+ C+S+CL
Sbjct: 616 CHEEC-AESCTAPGPDQCLGECKHFKSGDTCVKRCSKEQ-YAEEKQKLCQPCNSKCL 670
Score = 48.0 bits (109), Expect = 0.002
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 627 IACRKCHPLCIK-CVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSEC 685
+ C +CH C + C G +Q C FK GD C C + + +E + C PC+S+C
Sbjct: 611 VKCARCHEECAESCTAPG-PDQCLGECKHFKSGDTCVKRCSKEQYAEEKQKLCQPCNSKC 669
Score = 46.8 bits (106), Expect = 0.004
Identities = 27/99 (27%), Positives = 42/99 (42%), Gaps = 13/99 (13%)
Query: 460 KNNLVCDPQCSADG----CWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQC 515
+ N C CS + CWGP +QC C + + L + +C
Sbjct: 213 RRNTTCHSACSENDEKGHCWGPEKNQC------QLRSKCTKESTTYCRLDNPFERI--KC 264
Query: 516 HSECLDGCTGASRANCTSCKHVRDGPYCVAQCPESRYAS 554
C+ GC G S +NC +C+ R+G CV+ CP + +
Sbjct: 265 DDACIGGCNG-STSNCWACRSKRNGDTCVSFCPPRHHVN 302
Score = 44.4 bits (100), Expect = 0.022
Identities = 26/104 (25%), Positives = 44/104 (42%), Gaps = 23/104 (22%)
Query: 452 NGDPRQCEKNNLVCDPQCSADGCWGPGP--DQCLSCQNYNFGEICIDNC----SVHPGLY 505
N D ++C + C P+C C GPG C C+N+ + C++ C + P
Sbjct: 749 NADLQEC----VPCHPECEV--CVGPGNHVSVCRKCRNWMYRSECVNACPPDDTYVPNAT 802
Query: 506 KADH-----------KSCKQCHSECLDGCTGASRANCTSCKHVR 538
+H + C +CH +C GCT C +C++ +
Sbjct: 803 ATEHLSEREKQMLERRECLRCHEQCAGGCTAYGPEFCNNCRYAK 846
Score = 37.9 bits (84), Expect = 1.9
Identities = 16/38 (42%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 195 CNTFCAGGCTGPLPTQCLA-CRNFYDEGTCSQECPSMQ 231
C+ CA CT P P QCL C++F TC + C Q
Sbjct: 616 CHEECAESCTAPGPDQCLGECKHFKSGDTCVKRCSKEQ 653
>UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2;
Culicidae|Rep: Tyrosine-protein kinase shark - Aedes
aegypti (Yellowfever mosquito)
Length = 939
Score = 238 bits (582), Expect = 9e-61
Identities = 121/280 (43%), Positives = 177/280 (63%), Gaps = 6/280 (2%)
Query: 813 RPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTG 872
R T+ +PN I KE L + +LG G FG VY+G+ P+ + P+AIK L E+TG
Sbjct: 643 RTTSNRPNYF---IPKECILTQK-VLGRGEFGYVYQGLLRPQEPSDCTPIAIKQLVESTG 698
Query: 873 ANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSK 932
+FL EA +M + H +++L+ +C +M++ +L+PLG ++DY+ +K I K
Sbjct: 699 KRNRVDFLREASVMIRLRHHCIVKLIGICKGPPLMMVEELVPLGSMLDYIIANKGTINPK 758
Query: 933 AFLN-WCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA 991
L W QIA GM YLE+ VHRDLAARN+L+ + N KI+DFGL++ + +D Y+A
Sbjct: 759 LELVIWAAQIACGMQYLEQHHFVHRDLAARNILLASRNQAKISDFGLSRAIGAGDDYYRA 818
Query: 992 A-GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENG 1050
+ GGK PIKW A E + F+H SDVW+FGVT+WE+ S GA PY+++ +V +LIENG
Sbjct: 819 SQGGKWPIKWYAPESFNYGTFSHASDVWSFGVTMWEMYSLGAPPYQDMKGVDVIKLIENG 878
Query: 1051 LKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
+L QP +C +++ VM +CW + SRPTFK L F +
Sbjct: 879 QRLSQPDLCPENVFEVMKNCWNYNPKSRPTFKFLTRFFTD 918
>UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hydra
vulgaris|Rep: Tyrosine-protein kinase HTK16 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 757
Score = 233 bits (569), Expect = 3e-59
Identities = 109/271 (40%), Positives = 167/271 (61%), Gaps = 2/271 (0%)
Query: 820 NLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEF 879
N A+ I+ + + G LG G FG V KG+W+ G +I VA+K L + KEF
Sbjct: 472 NNAQQNIILKESISFGKELGVGEFGSVIKGIWLSPGGK-EINVAMKTLHKDKMVQGEKEF 530
Query: 880 LEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCT 939
L EA +M+ + HP ++ LL VC+ M+L+ +L+ +G L+DY+ ++ +I W +
Sbjct: 531 LREALVMSQLNHPCIVSLLGVCLGPPMILVQELVEMGALLDYLMDYQPEIQEVDLKLWAS 590
Query: 940 QIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPI 998
QIA GM YLE KR VHRDLAARN+L+ VKI+DFGL++ + D Y+A GG+ P+
Sbjct: 591 QIAFGMMYLELKRFVHRDLAARNILLANKKQVKISDFGLSRAVGTGSDYYQAKQGGRWPV 650
Query: 999 KWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSI 1058
+W A E I + F+ KSDVW++G+T+WE+ ++G PY ++ V +E+ +L +P
Sbjct: 651 RWYAPESINYGTFSTKSDVWSYGITLWEMFTFGDLPYGEMTGNEVVSFLEHCGRLEKPDE 710
Query: 1059 CTLDIYCVMVSCWMLDADSRPTFKQLADTFA 1089
C + Y +M+SCW +D + RPTF +L TF+
Sbjct: 711 CPIHTYSIMLSCWHIDPNKRPTFNELHSTFS 741
>UniRef50_Q6QMR8 Cluster: EGFR8; n=3; Clupeocephala|Rep: EGFR8 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 389
Score = 232 bits (568), Expect = 4e-59
Identities = 125/299 (41%), Positives = 174/299 (58%), Gaps = 20/299 (6%)
Query: 8 DTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKVHKIVLPQ 67
+ HY+ L + NCT V NLE+T + E DLSFLK I+EV GYVLI+ V KI L
Sbjct: 42 EDHYQVLLRMYRNCTVVLENLEITHI-TEKYDLSFLKSIQEVGGYVLIAVNTVSKIPLEN 100
Query: 68 LQIIRGRTLFKLNVREEEFALLVTMSTAFTLE-------LPALRDVLQGSVGIYSNFNLC 120
L+IIRG +L+ E++FAL V ++ ++E L +L ++L+G V N LC
Sbjct: 101 LRIIRGHSLY-----EDKFALAVLVNFNNSIEQGVKELPLTSLTEILKGGVKFCRNDYLC 155
Query: 121 HVKTINWDEINQDLTQVTFTFIILPLGKGNARVVTQPARWAA-GESIENCQKFSKTICSP 179
+V TI W +I + T + GK + + G + CQ+ +K I +
Sbjct: 156 NVGTIEWADILNMKSLPTIVSHNISYGKNCGKCDPSCFNGSCWGTGPDKCQRMTKVIYAE 215
Query: 180 QCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQIYNPTTYS 239
+C+ GRC GP P DCCN CA GCTGP PT CLAC++F DEGTC CP + +Y+P T+
Sbjct: 216 RCS-GRCKGPRPIDCCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQ 274
Query: 240 WEPNPNGKYAYGATCVRNCP-EHLLKDNGACVRSCPPNKTAVN----GECIPCVGTCPK 293
PNP GKY++GATC++ CP +++ D+GACVR+C P V+ +C C G CPK
Sbjct: 275 LAPNPYGKYSFGATCIKTCPHNYVVTDHGACVRTCSPGTYEVDEGGVRKCKRCEGLCPK 333
Score = 79.8 bits (188), Expect = 5e-13
Identities = 57/206 (27%), Positives = 78/206 (37%), Gaps = 22/206 (10%)
Query: 350 LEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXXXXXX 409
L +++EV GY+ + N S NL +I G + E+ FA +V
Sbjct: 73 LSFLKSIQEVGGYVLIAV---NTVSKIPLENLRIIRGHSLYEDKFALAVLVNFNNSIEQG 129
Query: 410 XXXXXVNS------GAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKN-GDPRQCEKNN 462
+ S G + N LC I W ++ K I+ N + C K
Sbjct: 130 VKELPLTSLTEILKGGVKFCRNDYLCNVGTIEWADILNMKSLPTIVSHNISYGKNCGK-- 187
Query: 463 LVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDG 522
CDP C CWG GPD+C + E C C G D C C+ C G
Sbjct: 188 --CDPSCFNGSCWGTGPDKCQRMTKVIYAERCSGRCK---GPRPID---C--CNEHCAAG 237
Query: 523 CTGASRANCTSCKHVRDGPYCVAQCP 548
CTG +C +CK +D C CP
Sbjct: 238 CTGPRPTDCLACKDFQDEGTCKDACP 263
Score = 47.6 bits (108), Expect = 0.002
Identities = 32/98 (32%), Positives = 37/98 (37%), Gaps = 20/98 (20%)
Query: 629 CRKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECK-G 687
C KC P C +G CQ ++C C D C C+ C G
Sbjct: 185 CGKCDPSCFNGSCWGTGPDKCQRMTKVIYAERCSGRCKGPRPID-----C--CNEHCAAG 237
Query: 688 CTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCP 725
CTGP PTDC+ CK D DE C D CP
Sbjct: 238 CTGPRPTDCLACK---------DFQDEG---TCKDACP 263
>UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 743
Score = 232 bits (568), Expect = 4e-59
Identities = 115/269 (42%), Positives = 167/269 (62%), Gaps = 4/269 (1%)
Query: 823 KLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEE 882
+L + E +L G LG G FG V KG++ + KI VA+K L+ + + KEF E
Sbjct: 456 QLSYISEHDLHLGAELGQGEFGSVLKGLY-KGADGKKIEVAVKTLRLDSQGHGEKEFARE 514
Query: 883 AYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLN-WCTQI 941
A IM ++ HP +++L+ + MM++ +L+ +G LVDY+ K+ I L W +I
Sbjct: 515 AGIMVTLNHPCIVKLIGITNGKPMMMVQELISMGALVDYLYERKQPIPDVLTLKLWAAEI 574
Query: 942 ARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKW 1000
A GM YLE KR VHRDLAARN+LVQ+ VKI+DFGL++ + N D YKA+ GG+ P+KW
Sbjct: 575 ASGMMYLETKRFVHRDLAARNILVQSMKQVKISDFGLSRAVGANSDYYKASQGGRWPVKW 634
Query: 1001 LALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIEN-GLKLPQPSIC 1059
A E I F+H SDVW++G+T+WE+ S+G PY +++ V + +EN +L P C
Sbjct: 635 YAPESINFGTFSHASDVWSYGITLWEMFSFGDAPYGDMTGAEVLDRVENLNYRLECPRDC 694
Query: 1060 TLDIYCVMVSCWMLDADSRPTFKQLADTF 1088
IY +M+ CW L+ + RPTF QL D+F
Sbjct: 695 PSSIYELMLRCWSLEPNERPTFAQLYDSF 723
>UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus
variegatus|Rep: Focal adhesion kinase - Lytechinus
variegatus (Sea urchin)
Length = 1006
Score = 227 bits (556), Expect = 1e-57
Identities = 105/257 (40%), Positives = 161/257 (62%), Gaps = 3/257 (1%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
+G G FG V+KG+++ + E K+ VA+K K + + FLEEAYIM +HP++++L
Sbjct: 444 IGQGQFGDVHKGIYIDQDE--KVEVAVKTCKVESTQALGERFLEEAYIMKQFDHPHIIKL 501
Query: 898 LAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRD 957
+ VC + ++ +L P G + +++THKE++ + + + Q++ ++YLE K+ VHRD
Sbjct: 502 IGVCTDPPIWIVMELAPFGEMRMFLQTHKEELTLASLILYAYQLSMALSYLESKKFVHRD 561
Query: 958 LAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDV 1017
+AARN+LV ++VK+ DFGL++LL + YKA+ GK+PIKW+A E I R FT SDV
Sbjct: 562 IAARNLLVVAKDNVKLGDFGLSRLLH-DHSYYKASKGKLPIKWMAPESINFRRFTSASDV 620
Query: 1018 WAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADS 1077
W FGV +WEIL YG +P++ + V IENG +LP P+ C +Y VM CW +
Sbjct: 621 WMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSK 680
Query: 1078 RPTFKQLADTFAEMARD 1094
RP FK L E+ +
Sbjct: 681 RPNFKDLKTRLNEILEE 697
>UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG10023-PA, isoform A - Tribolium castaneum
Length = 1106
Score = 225 bits (550), Expect = 7e-57
Identities = 104/261 (39%), Positives = 166/261 (63%), Gaps = 1/261 (0%)
Query: 831 ELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVE 890
+++ G +LG G FG V+KG + + ++ IPVA+K K NT+++FLEEAYIM +
Sbjct: 427 QIQLGEILGEGQFGDVHKGTYKAKDGSL-IPVAVKTCKREADLNTTEKFLEEAYIMQKFD 485
Query: 891 HPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEE 950
H ++++L+ VC + + ++ +L LG L Y++ +K+ + L + Q++ ++YLE
Sbjct: 486 HQHIIKLIGVCSESPVWIVMELAKLGELRAYLQNNKDDLDLATLLLYAFQLSTALSYLES 545
Query: 951 KRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRI 1010
K+ VHRD+AARNVLV + SVK+ DFGL++ ++ ++ YKA+ GK+PIKW++ E I R
Sbjct: 546 KKFVHRDIAARNVLVSSHTSVKLGDFGLSRSMNDDQSYYKASKGKLPIKWMSPESINFRR 605
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
FT SDVW FGV +WEIL YG +P++ + V IENG +L P C +Y +M C
Sbjct: 606 FTIASDVWMFGVCMWEILMYGIKPFQGVKNNEVLTKIENGERLALPPNCPPRLYSLMSQC 665
Query: 1071 WMLDADSRPTFKQLADTFAEM 1091
W + RP+FK++ + E+
Sbjct: 666 WSYEPSKRPSFKEIKEILNEI 686
>UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep:
Tyrosine kinase - Schistosoma mansoni (Blood fluke)
Length = 1264
Score = 222 bits (543), Expect = 5e-56
Identities = 111/259 (42%), Positives = 160/259 (61%), Gaps = 6/259 (2%)
Query: 838 LGFGAFGKVYKGVW-VPEGENVKIPVAIKVLKETTGANTS-KEFLEEAYIMASVEHPNLL 895
LG G FG V KG++ P G+ V PVA+K LK AN+ +E L EA MA ++H +++
Sbjct: 894 LGGGNFGHVVKGLYRTPSGQEV--PVAVKTLKPNQIANSGEREILAEARTMAQLKHRHIV 951
Query: 896 QLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
+L+ VC Q ML+ +L PLG + Y++ + + Q+A GMAYLE + VH
Sbjct: 952 RLIGVCKEEQFMLVLELAPLGPINKYLKKRPD-VSVHTLTELMHQVALGMAYLESCKFVH 1010
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQHRIFTHK 1014
RDLAARNVL+ T + KI+DFG++K L+ D Y+AA GK P+KW A ECI + F K
Sbjct: 1011 RDLAARNVLLVTRHFAKISDFGMSKALNFGSDYYRAATAGKWPLKWYAPECIYYFRFDSK 1070
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVW++G+T+WE+ SYG RPY ++ + +++ GL+L +PS C IY +M CW +
Sbjct: 1071 SDVWSYGITLWEVYSYGERPYRDMKGAQILAMLDQGLRLSRPSRCPESIYSIMQQCWNFE 1130
Query: 1075 ADSRPTFKQLADTFAEMAR 1093
RPTF +L T + + R
Sbjct: 1131 GVHRPTFAELVLTISRILR 1149
>UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2;
Sophophora|Rep: Tyrosine-protein kinase shark -
Drosophila melanogaster (Fruit fly)
Length = 939
Score = 221 bits (540), Expect = 1e-55
Identities = 121/292 (41%), Positives = 172/292 (58%), Gaps = 13/292 (4%)
Query: 811 PLRPTNVKPNLAKLRIVKEAE-LRRGGMLGFGAFGKVYKGVWVPE----GENVKIPVAIK 865
P P+ + AKLR E E L +G G FG V+ G W+ GE ++ VAIK
Sbjct: 640 PSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIK 698
Query: 866 VLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTH 925
+L + + +EFL EA +M +EH +++L+ + +M++ +L PLG ++ Y+ H
Sbjct: 699 MLSDEH--SNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDH 756
Query: 926 KEKIGSKAFLN-WCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDI 984
+I + A L W +QIA GM YLE + VHRDLAARN+L+ + KI+DFG+++ L
Sbjct: 757 GHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRP 816
Query: 985 NEDEYK-AAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNV 1043
EY+ GG+ PI+W A E IF+H SDVW+FGVTIWE+ S GA PY IS +
Sbjct: 817 GSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDA 876
Query: 1044 PELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
+L+++G +LPQP++C IY VM SCW RPTF L + F ARDP
Sbjct: 877 IKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF---ARDP 925
>UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to
protein-tyrosine kinase; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to protein-tyrosine
kinase - Strongylocentrotus purpuratus
Length = 837
Score = 219 bits (536), Expect = 3e-55
Identities = 109/269 (40%), Positives = 162/269 (60%), Gaps = 5/269 (1%)
Query: 823 KLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEE 882
+++ + + + RG +G G FG V +G + + VK VA+K L KEFL E
Sbjct: 554 EVQCIDASLIERGNEIGQGEFGSVLEGKYKEKDRWVK--VALKTLHADHLQTGQKEFLRE 611
Query: 883 AYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIA 942
A +M ++HP +++L+ VC+ MML+ +L+ G L+D+++ + I + W TQIA
Sbjct: 612 AKVMCGLDHPCIVKLMGVCLGPPMMLVQELVSQGALLDFLQN--DSITASDLKLWATQIA 669
Query: 943 RGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWL 1001
GM YLE K+ VHRDLAARN+L++ KI+DFGL++ N D Y++ GG+ P+KW
Sbjct: 670 SGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGRWPVKWY 729
Query: 1002 ALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTL 1061
A E I + F+H SDVW FGVT+WE+ S GA+PY + V + IENG +L +P C
Sbjct: 730 APESIYYGTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIENGHRLNRPEGCPQ 789
Query: 1062 DIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
++Y +M CW +RPTF QL D F +
Sbjct: 790 NVYQIMNKCWSYKPCNRPTFSQLNDMFRD 818
>UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG18247-PA - Tribolium castaneum
Length = 725
Score = 219 bits (534), Expect = 6e-55
Identities = 107/261 (40%), Positives = 166/261 (63%), Gaps = 6/261 (2%)
Query: 832 LRRGGMLGFGAFGKVYKGVWVPE-GENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVE 890
L+ G ++G G FG VY+G + GE +K VAIK ++ TS L+EA++M +
Sbjct: 450 LKMGRVIGEGEFGSVYEGTYTKRNGEEIK--VAIKTVRHEQ-IETSNAILKEAHVMMRLN 506
Query: 891 HPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKA-FLNWCTQIARGMAYLE 949
H +++L+ + ++++ +L+ LG +++Y+ +KE I + F W QIA GM YLE
Sbjct: 507 HHCVVKLIGLSKGRPLLMVQELVALGSMLNYIILNKESINPNSEFKIWAAQIACGMNYLE 566
Query: 950 EKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQH 1008
E+R +HRDLAARN+L+ + + KI+DFGL++ L + + Y+A GGK P+KW A E +
Sbjct: 567 EQRFIHRDLAARNILLASQHQAKISDFGLSRALAADHEYYRALQGGKWPLKWYAPESYNY 626
Query: 1009 RIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMV 1068
F+HKSDVW+FGV IWE+ S+G PY + + ++IE+G +L QP C IY +M
Sbjct: 627 GQFSHKSDVWSFGVAIWEMYSFGDVPYGELKGSDAIKIIEDGERLKQPDACPDHIYEIMR 686
Query: 1069 SCWMLDADSRPTFKQLADTFA 1089
CW DA++RPTFK+L + F+
Sbjct: 687 RCWEYDAENRPTFKELLEFFS 707
>UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephrin
receptor - Gallus gallus (Chicken)
Length = 969
Score = 218 bits (532), Expect = 1e-54
Identities = 131/364 (35%), Positives = 200/364 (54%), Gaps = 16/364 (4%)
Query: 745 PYCSEHA-NDIPTAT-ARTSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMV 802
PY E +P T A + V+ I+ LF+ +L +G F ++ KA + +
Sbjct: 520 PYSQEQEFRTLPPGTGALSGGVMASIIFGVLLFIGLL--LGILFFRRKKAHRRQARPDYS 577
Query: 803 LTGCEDNEP-LRP-TNVKP----NLAKLRIVKEAELR---RGGMLGFGAFGKVYKGVWVP 853
+G + + L+P +++P + L +KE ++ ++G G FG+VY+G
Sbjct: 578 TSGFDREKVWLKPYVDLQPYDDPSRGVLEFIKELDVSCVTMENVIGEGEFGEVYRGSLRL 637
Query: 854 EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQL 912
G+ +I VAIK LK T + FL EA IM HPN++ L V + MM+IT+
Sbjct: 638 PGKE-RIVVAIKTLKSTYSDSQWWNFLREATIMGQFNHPNIVHLEGVVTKRRPMMIITEY 696
Query: 913 MPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVK 972
M G L ++R ++EK +N IA GM YL E VHRDLAARN+LV K
Sbjct: 697 MENGALDTFLRENEEKFSPVQLVNMLQGIASGMTYLSEHNYVHRDLAARNILVTRSLQCK 756
Query: 973 ITDFGLAKLLDIN-EDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYG 1031
++DFGL+++L+ + E Y+ GGK+PI+W A E I HRIFT SDVW+FG+ +WE+LS+G
Sbjct: 757 VSDFGLSRILENDAEGTYETKGGKIPIRWTAPEAIAHRIFTSASDVWSFGIVMWEVLSFG 816
Query: 1032 ARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
+PY N++ + V + +E+G +LP P C +Y +M SCW D RP F+++
Sbjct: 817 DKPYGNMTNQEVMKSLEDGYRLPPPVDCPSILYELMKSCWSHDRMRRPHFQEIRAQLQHF 876
Query: 1092 ARDP 1095
+ P
Sbjct: 877 SSSP 880
>UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein
tyrosine kinase; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to protein tyrosine kinase - Nasonia vitripennis
Length = 739
Score = 216 bits (527), Expect = 4e-54
Identities = 111/258 (43%), Positives = 161/258 (62%), Gaps = 6/258 (2%)
Query: 835 GGMLGFGAFGKVYKGVW-VPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPN 893
G +LG G FG VY+G++ P G + PVAIK+L++T T +EFL EA +M + H
Sbjct: 467 GEVLGEGEFGAVYEGLFDSPSG--TQEPVAIKMLRDTHNIATREEFLREARLMMTFNHHC 524
Query: 894 LLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLN-WCTQIARGMAYLEEKR 952
+++L+ ++++ +L+ LG ++ Y+ ++I L W +QIA GM YLEE R
Sbjct: 525 IVKLIGFSEGPPLLMVQELVSLGSMLAYLLEFPDRINPNYELKVWASQIACGMKYLEEIR 584
Query: 953 LVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWLALECIQHRIF 1011
LVHRDLAARN+L+ + + KI+DFGL++ N D YKA AGGK PIKW A E + F
Sbjct: 585 LVHRDLAARNILLASKHQAKISDFGLSRTFGSN-DYYKATAGGKWPIKWYAPESYNYGTF 643
Query: 1012 THKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCW 1071
+H SDVW++G+T+WE+ SYG +PY + V +L+E G +L QP C +Y VM CW
Sbjct: 644 SHASDVWSYGITLWEMFSYGEQPYGDRRGTEVIDLVEKGDRLAQPEQCPDHVYKVMQKCW 703
Query: 1072 MLDADSRPTFKQLADTFA 1089
RPTF++L D F+
Sbjct: 704 SYSPADRPTFQELLDIFS 721
>UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5;
Eumetazoa|Rep: Tyrosine-protein kinase Abl - Drosophila
melanogaster (Fruit fly)
Length = 1620
Score = 216 bits (527), Expect = 4e-54
Identities = 116/260 (44%), Positives = 158/260 (60%), Gaps = 11/260 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G +G+VY+ VW G V A+K LKE T A K+FLEEA IM ++HPNL+QL
Sbjct: 377 LGGGQYGEVYEAVWKRYGNTV----AVKTLKEDTMA--LKDFLEEAAIMKEMKHPNLVQL 430
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTH-KEKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
+ VC +IT+ M G L+D++R+ +E + + A L TQIA GM+YLE + +H
Sbjct: 431 IGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIH 490
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWLALECIQHRIFTHK 1014
RDLAARN LV VK+ DFGLA+L+ +D Y A AG K PIKW A E + + F+ K
Sbjct: 491 RDLAARNCLVGDNKLVKVADFGLARLM--RDDTYTAHAGAKFPIKWTAPEGLAYNKFSTK 548
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVWAFGV +WEI +YG PY I +V ++ G ++ +P C ++Y +M CW D
Sbjct: 549 SDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWD 608
Query: 1075 ADSRPTFKQLADTFAEMARD 1094
A RPTFK + M ++
Sbjct: 609 ATDRPTFKSIHHALEHMFQE 628
>UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38;
Euteleostomi|Rep: Tyrosine-protein kinase ABL2 - Homo
sapiens (Human)
Length = 1182
Score = 216 bits (527), Expect = 4e-54
Identities = 113/260 (43%), Positives = 157/260 (60%), Gaps = 11/260 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G +G+VY GVW + + VA+K LKE T +EFL+EA +M ++HPNL+QL
Sbjct: 294 LGGGQYGEVYVGVW----KKYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHPNLVQL 347
Query: 898 LAVC-MTNQMMLITQLMPLGCLVDYVRT-HKEKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
L VC + ++T+ MP G L+DY+R ++E++ + L TQI+ M YLE+K +H
Sbjct: 348 LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH 407
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWLALECIQHRIFTHK 1014
RDLAARN LV + VK+ DFGL++L+ D Y A AG K PIKW A E + + F+ K
Sbjct: 408 RDLAARNCLVGENHVVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESLAYNTFSIK 465
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVWAFGV +WEI +YG PY I V +L+E G ++ QP C +Y +M +CW
Sbjct: 466 SDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWS 525
Query: 1075 ADSRPTFKQLADTFAEMARD 1094
RP+F + F M D
Sbjct: 526 PADRPSFAETHQAFETMFHD 545
>UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-oncogene
tyrosine-protein kinase abl1; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to proto-oncogene
tyrosine-protein kinase abl1 - Nasonia vitripennis
Length = 1522
Score = 214 bits (522), Expect = 2e-53
Identities = 112/260 (43%), Positives = 157/260 (60%), Gaps = 11/260 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G +G VY+ VW + + VA+K LKE T A K+FLEEA IM ++H NL+QL
Sbjct: 296 LGGGQYGDVYEAVW----KRYNMTVAVKTLKEDTMA--LKDFLEEAAIMKEMKHRNLVQL 349
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTH-KEKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
+ VC +IT+ M G L+DY+R K +I + ++ TQIA GM+YLE + +H
Sbjct: 350 IGVCTREPPFYIITEFMSKGNLLDYLRNESKHQINAVVLMHMATQIASGMSYLESRNFIH 409
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWLALECIQHRIFTHK 1014
RDLAARN LV + VK+ DFGLA+L+ +D Y A AG K PIKW A E + + F+ K
Sbjct: 410 RDLAARNCLVGESHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWTAPEGLAYNKFSTK 467
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVWAFG+ +WEI +YG PY + +V ++E G ++ P C +Y +M CW
Sbjct: 468 SDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEKGYRMECPPGCPPKVYELMRQCWQWS 527
Query: 1075 ADSRPTFKQLADTFAEMARD 1094
A RPTFK++ + M ++
Sbjct: 528 ASDRPTFKEIHHSLENMFQE 547
>UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming protein
Abl; n=15; root|Rep: Tyrosine-protein kinase transforming
protein Abl - Abelson murine leukemia virus
Length = 746
Score = 214 bits (522), Expect = 2e-53
Identities = 116/287 (40%), Positives = 169/287 (58%), Gaps = 14/287 (4%)
Query: 813 RPT--NVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKET 870
+PT V PN K + + ++ LG G +G+VY+GVW + + VA+K LKE
Sbjct: 108 KPTIYGVSPNYDKWEM-ERTDITMKHKLGGGQYGEVYEGVW----KKYSLTVAVKTLKED 162
Query: 871 TGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRT-HKEK 928
T +EFL+EA +M ++HPNL+QLL VC +IT+ M G L+DY+R ++++
Sbjct: 163 T--MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE 220
Query: 929 IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE 988
+ + L TQI+ M YLE+K +HRDLAARN LV + VK+ DFGL++L+ D
Sbjct: 221 VSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDT 278
Query: 989 YKA-AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELI 1047
Y A AG K PIKW A E + + F+ KSDVWAFGV +WEI +YG PY I V EL+
Sbjct: 279 YTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL 338
Query: 1048 ENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
E ++ +P C +Y +M +CW + RP+F ++ F M ++
Sbjct: 339 EKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE 385
>UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ABL1;
n=35; root|Rep: Proto-oncogene tyrosine-protein kinase
ABL1 - Homo sapiens (Human)
Length = 1130
Score = 214 bits (522), Expect = 2e-53
Identities = 116/287 (40%), Positives = 169/287 (58%), Gaps = 14/287 (4%)
Query: 813 RPT--NVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKET 870
+PT V PN K + + ++ LG G +G+VY+GVW + + VA+K LKE
Sbjct: 222 KPTVYGVSPNYDKWEM-ERTDITMKHKLGGGQYGEVYEGVW----KKYSLTVAVKTLKED 276
Query: 871 TGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRT-HKEK 928
T +EFL+EA +M ++HPNL+QLL VC +IT+ M G L+DY+R ++++
Sbjct: 277 T--MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE 334
Query: 929 IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE 988
+ + L TQI+ M YLE+K +HRDLAARN LV + VK+ DFGL++L+ D
Sbjct: 335 VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDT 392
Query: 989 YKA-AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELI 1047
Y A AG K PIKW A E + + F+ KSDVWAFGV +WEI +YG PY I V EL+
Sbjct: 393 YTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL 452
Query: 1048 ENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
E ++ +P C +Y +M +CW + RP+F ++ F M ++
Sbjct: 453 EKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE 499
>UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosine
kinase CG4032-PA; n=1; Apis mellifera|Rep: PREDICTED:
similar to Abl tyrosine kinase CG4032-PA - Apis mellifera
Length = 1439
Score = 213 bits (521), Expect = 2e-53
Identities = 113/260 (43%), Positives = 157/260 (60%), Gaps = 11/260 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G +G VY+ VW + + VA+K LKE T A K+FLEEA IM ++H NL+QL
Sbjct: 295 LGGGQYGDVYEAVW----KRYNMTVAVKTLKEDTMA--LKDFLEEAAIMKEMKHRNLVQL 348
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTH-KEKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
L VC +IT+ M G L+DY+R K +I + ++ TQIA GM+YLE + +H
Sbjct: 349 LGVCTREPPFYIITEFMSKGNLLDYLRNESKHQINAVVLMHMATQIASGMSYLESRNFIH 408
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWLALECIQHRIFTHK 1014
RDLAARN LV + VK+ DFGLA+L+ +D Y A AG K PIKW A E + + F+ K
Sbjct: 409 RDLAARNCLVGENHLVKVADFGLARLM--RDDTYTAHAGAKFPIKWTAPEGLAYNKFSTK 466
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVWAFG+ +WEI +YG PY + +V ++E G ++ P C +Y +M CW
Sbjct: 467 SDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEKGYRMECPPGCPPKVYELMRQCWQWS 526
Query: 1075 ADSRPTFKQLADTFAEMARD 1094
A RPTFK++ + M ++
Sbjct: 527 AADRPTFKEIHHSLENMFQE 546
>UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 573
Score = 213 bits (520), Expect = 3e-53
Identities = 104/269 (38%), Positives = 163/269 (60%), Gaps = 3/269 (1%)
Query: 825 RIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGA-NTSKEFLEEA 883
R ++++EL G LG G FG V GV+ P+ ++ A+K LK++ N E L EA
Sbjct: 279 RRIEDSELSTQGELGAGTFGTVRLGVYRPKNGEPEVQCALKYLKQSEELPNQKAEILREA 338
Query: 884 YIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIAR 943
MA+++H N+++L +C+ + + L+ +L G L ++R K LN Q++R
Sbjct: 339 DAMAALDHCNIVRLFGICVGDPICLVMELARQGPLNKFLRKRPTFPVIK-ILNMALQVSR 397
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWLA 1002
GMAYLEE R VHRDLAARNVLV ++VKI+DFG+++ + + YKA G+ P+KW A
Sbjct: 398 GMAYLEEVRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGAGSEYYKAETAGRWPLKWYA 457
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLD 1062
ECI + F KSDVW++GVT+WE S+GA+PY + +++ +++E +L P C
Sbjct: 458 PECIYYAKFDSKSDVWSYGVTVWEAFSFGAKPYAGLKGQDIMQMLEGNQRLDSPEKCPQP 517
Query: 1063 IYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
IY +M+ CW + RP+F +L+ ++
Sbjct: 518 IYDIMLRCWAWRPEDRPSFSELSSMLKDI 546
>UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2;
Anthomedusae|Rep: Protein-tyrosine kinase - Hydractinia
echinata (Snail fur) (Hermit crab hydroid)
Length = 1162
Score = 213 bits (520), Expect = 3e-53
Identities = 102/278 (36%), Positives = 164/278 (58%), Gaps = 5/278 (1%)
Query: 819 PNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLK-----ETTGA 873
P AK V +L ++G G FG VY+G + + +V+IPVA+K K E
Sbjct: 416 PMSAKDYEVARDDLTLDEIIGQGQFGDVYQGTFKSKISSVEIPVAVKTYKIELDKEQEDG 475
Query: 874 NTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKA 933
+++FLEEAY+M +HP++++L+ + + +I +L G L Y++ ++ + S+
Sbjct: 476 TRAEKFLEEAYLMQQFDHPHVIKLIGIVSDSPSYIIMELASYGELRSYLQQYRTQTESER 535
Query: 934 FLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAG 993
L + Q++ ++YLE + VHRD+AARN+L P+++K+ DFGL++ +D + YKA+
Sbjct: 536 LLTYIYQLSTALSYLESRNFVHRDIAARNILAADPHTIKLADFGLSRWIDEEQSYYKASK 595
Query: 994 GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKL 1053
GK+PIKW+A E I R F+ SDVW FGV WEIL YG +P++ + V IENG +L
Sbjct: 596 GKLPIKWMAPESINFRRFSSASDVWMFGVCCWEILMYGVKPFQGVPNEKVIGKIENGERL 655
Query: 1054 PQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
P P C +Y +M W + RPTF++L +++
Sbjct: 656 PLPPNCAPTLYHLMTESWHYEPSKRPTFQELKSRLSQI 693
>UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111;
Euteleostomi|Rep: Focal adhesion kinase 1 - Homo sapiens
(Human)
Length = 1052
Score = 213 bits (520), Expect = 3e-53
Identities = 105/270 (38%), Positives = 161/270 (59%), Gaps = 3/270 (1%)
Query: 815 TNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGAN 874
T P+ I +E + G +G G FG V++G+++ EN + VAIK K T +
Sbjct: 406 TYTMPSTRDYEIQRE-RIELGRCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDS 463
Query: 875 TSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
++FL+EA M +HP++++L+ V N + +I +L LG L +++ K + +
Sbjct: 464 VREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASL 523
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG 994
+ + Q++ +AYLE KR VHRD+AARNVLV + + VK+ DFGL++ ++ + YKA+ G
Sbjct: 524 ILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKG 582
Query: 995 KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLP 1054
K+PIKW+A E I R FT SDVW FGV +WEIL +G +P++ + +V IENG +LP
Sbjct: 583 KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP 642
Query: 1055 QPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
P C +Y +M CW D RP F +L
Sbjct: 643 MPPNCPPTLYSLMTKCWAYDPSRRPRFTEL 672
>UniRef50_Q4S1Y7 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=2; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14764,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 874
Score = 213 bits (519), Expect = 4e-53
Identities = 130/396 (32%), Positives = 180/396 (45%), Gaps = 55/396 (13%)
Query: 173 SKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQI 232
+K C+ QC++ RC GP P DCCN CA GCTGP QCLACR+F DEGTC C S
Sbjct: 102 TKLQCAEQCSR-RCRGPKPSDCCNRHCAAGCTGPQADQCLACRDFNDEGTCKDTCRSHMF 160
Query: 233 YNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAV--NG--ECIPCV 288
+N + PNP+ KYA+G CV+ CP + + G CVR+C V NG +C C
Sbjct: 161 HNSKIHRGVPNPDAKYAFGPICVKACPHNYVVTEGWCVRTCRAGMFEVEENGVQQCRECN 220
Query: 289 GTCPKTC--------RAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGE 340
G CPK C +++ NI+ F++CT I+G++ +E +FTG
Sbjct: 221 GPCPKVCDGLGVGAFNNSVAVNASNIEFFRNCTKINGNVNFIETSFTG--------DLFH 272
Query: 341 RYPKMEPDALEVFSTVREVT--------------------GYLNVQAHHPNFTSLSYFRN 380
P M+P LE F TV+E+T G+L +Q+ N TSLS F N
Sbjct: 273 NIPPMDPAKLEYFRTVKEITGRGRPRRPLRLQLTSSSHRSGFLLIQSWPENLTSLSAFEN 332
Query: 381 LEVIGGRQVVENLFASLYIVKTXXXX-XXXXXXXXVNSGAIAIMENRNLCYADKIAWNKL 439
L +I GR N+ SL + +T V++G + + N LC+ + W L
Sbjct: 333 LHIIRGR-ATHNMRTSLVVTRTEHLRWLGLRSLKEVSAGRVMVKNNPQLCFLQPLQWTHL 391
Query: 440 VKSKDHKQIIQKNGDPRQCEKNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNC- 498
+S I+ N C K+ +D PGP QC C + G C+ +C
Sbjct: 392 FRSTGQTADIRNNKPVDVCSKSG----TGLLSDVPGPPGPGQCSQCAHVQDGPSCVAHCP 447
Query: 499 -------SVHPGLYKADHKSCKQCHSECLDGCTGAS 527
+Y C+ CH C G G S
Sbjct: 448 QGMLGEGDTEIWMYPDRAGRCQLCHQNCTQGSAGQS 483
Score = 198 bits (484), Expect = 7e-49
Identities = 107/235 (45%), Positives = 154/235 (65%), Gaps = 16/235 (6%)
Query: 766 VIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTG-CEDN---EPLRPTNVKPNL 821
++I+VI +L VL R++ ++ K VL G C+ + EPL P+ PN
Sbjct: 493 LLIVVIVALVTFVLLRRRRITRRRTLRRQLQEKEVAVLPGRCKGHSLVEPLTPSGEAPNQ 552
Query: 822 AKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLE 881
A LRI+KE E ++ +LG GAFG VYK + P++ ++ + S +
Sbjct: 553 AMLRIMKETEFKKIRVLGSGAFGTVYK---------ARKPISSDLI--IVSLSPSNHY-S 600
Query: 882 EAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQI 941
+AY+MAS++HP++ +LL +C+T+ + L+TQLMP GCL+DYVR H+++IG+ LNWC QI
Sbjct: 601 DAYVMASIDHPHVCRLLGICLTSSIQLVTQLMPFGCLLDYVRFHQDQIGAPWLLNWCVQI 660
Query: 942 ARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKM 996
A+GM+YLE + LVHRDLAARNVLV++P+ V ITDFGLAKLL NE Y+A GGK+
Sbjct: 661 AKGMSYLEGRHLVHRDLAARNVLVKSPSHVTITDFGLAKLLTANEKAYRADGGKV 715
Score = 148 bits (359), Expect = 9e-34
Identities = 57/107 (53%), Positives = 82/107 (76%)
Query: 995 KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLP 1054
K+PIKW+ALE I +TH+SDVW+FGVT+WE++++G++PY+ I A + ++E G +LP
Sbjct: 753 KVPIKWMALESILQSTYTHQSDVWSFGVTVWELMTFGSKPYDGIPASEISSVLERGERLP 812
Query: 1055 QPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVI 1101
P ICT D+Y +MV CWM+D SRPTF++L F+ MARDP R+LV+
Sbjct: 813 HPPICTTDLYMIMVQCWMIDPSSRPTFRKLTAEFSTMARDPSRFLVV 859
Score = 37.5 bits (83), Expect = 2.6
Identities = 12/19 (63%), Positives = 15/19 (78%)
Query: 531 CTSCKHVRDGPYCVAQCPE 549
C+ C HV+DGP CVA CP+
Sbjct: 430 CSQCAHVQDGPSCVAHCPQ 448
>UniRef50_UPI0000D563AD Cluster: PREDICTED: similar to CG3969-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG3969-PA, isoform A - Tribolium castaneum
Length = 1268
Score = 212 bits (518), Expect = 5e-53
Identities = 113/282 (40%), Positives = 166/282 (58%), Gaps = 12/282 (4%)
Query: 819 PNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKE 878
P ++ I+ A + LG G FG V +GVW EGE +I VAIK L + E
Sbjct: 110 PRVSSKHIIPAASITINKELGMGEFGVVQQGVWCNEGE--RIQVAIKCLSRDRMQSNMVE 167
Query: 879 FLEEAYIMASVEHPNLLQLLAVCMTN---QMMLITQLMPLGCLVDYVR--THKEKIGSKA 933
FL+EA IM +++HPN+++ V + N +ML+T+L PL L++ ++ + +
Sbjct: 168 FLKEASIMHNIDHPNIVRFFGVVLPNVEGSLMLVTELAPLRSLLECLKEPSLRSSFPVLT 227
Query: 934 FLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-- 991
++ QI GM YLE RL+HRDLAARN+LV + + VKI+DFGL++ L +D Y+
Sbjct: 228 LCDFAYQICDGMQYLEANRLIHRDLAARNILVFSKSKVKISDFGLSRALGQGKDYYQTNF 287
Query: 992 -AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE-- 1048
K+PI W A ECI + FT SDVWAFGVT+WE+ SYG +P+ ++ + + E I+
Sbjct: 288 NVNLKLPIAWCAPECISYLRFTTSSDVWAFGVTLWEMFSYGFQPWAALTGQQILEAIDEP 347
Query: 1049 NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
N +L QP C LD Y +M+ CW +A +RP F ++ AE
Sbjct: 348 NFQRLEQPDCCPLDHYNLMLDCWRHEASARPKFAEIGPVLAE 389
>UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hydra
vulgaris|Rep: Protein-tyrosine kinase HTK98 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 624
Score = 211 bits (516), Expect = 9e-53
Identities = 101/260 (38%), Positives = 160/260 (61%), Gaps = 3/260 (1%)
Query: 832 LRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEH 891
LR LG G FG V KGV++ + N + VA+K LKE E ++EA IM+ ++H
Sbjct: 357 LRLEHELGHGNFGSVVKGVYLLKN-NKSVAVAVKTLKEEDIPGQKSEIVKEAEIMSKLDH 415
Query: 892 PNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEK 951
PN+++L+ V + ML+ +L P G L +++ ++ + L Q+ GM YLE +
Sbjct: 416 PNIVRLIGVTQSPGFMLVMELAPQGPLHKFLKKNRN-MNVLDILVLMLQVDEGMNYLESQ 474
Query: 952 RLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQHRI 1010
VHRDLAARNVLV + N VKI+DFG+++ + + + Y+A GK P+KW A ECI +
Sbjct: 475 HFVHRDLAARNVLVVSENFVKISDFGMSRAMGVGNEYYRAERAGKWPLKWYAPECIYYHK 534
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
F+ K DVW++G+T+WE +SYG +PY+ + + E +E+G +LP+P C+ +Y +M+ C
Sbjct: 535 FSSKGDVWSYGITMWEAVSYGGKPYQGMRGPVIVEKLESGYRLPKPDNCSDAVYTLMLKC 594
Query: 1071 WMLDADSRPTFKQLADTFAE 1090
W + D RP+F ++ A+
Sbjct: 595 WETNPDDRPSFMEIGIILAQ 614
>UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; n=1;
Suberites domuncula|Rep: Bruton's tyrosine kinase-like
protein - Suberites domuncula (Sponge)
Length = 700
Score = 210 bits (512), Expect = 3e-52
Identities = 114/281 (40%), Positives = 164/281 (58%), Gaps = 12/281 (4%)
Query: 814 PTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGA 873
P ++ P + + + L G LG G FG+V G W +G KI VAIK+++E GA
Sbjct: 415 PQSLGPLFDEAWEIDKVSLSLGKELGSGQFGRVVSGKW--KG---KIDVAIKMMRE--GA 467
Query: 874 NTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQ-LMPLGCLVDYVRTHKEKIG-S 931
+F+EEA +M +H NL++L VC N + I Q LM GCL+ ++R KE + +
Sbjct: 468 MNEDDFIEEAKVMKQFQHENLVKLYGVCTKNGPIFIVQELMVNGCLLQFLRQRKELVEKT 527
Query: 932 KAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA 991
+ L+ TQI M YLEE +HRDLAARN LV N VK+ DFGLA+ + +DEY A
Sbjct: 528 EIILDMATQICSAMKYLEESGFIHRDLAARNCLVGERNVVKVADFGLARF--VVDDEYTA 585
Query: 992 AGG-KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENG 1050
+ G K PIKW A E I H F+ KSDVW+FG+ +WE+ + G PY + V + + G
Sbjct: 586 SEGTKFPIKWAAPEVITHAKFSSKSDVWSFGILLWELWTGGKTPYPTFTNSQVLDEVLMG 645
Query: 1051 LKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
+L +P C ++Y +M CW+ ++D RP FK L+ + +M
Sbjct: 646 YRLDRPKQCPPEVYALMGKCWLTNSDDRPQFKTLSSSLGQM 686
>UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming protein
Abl; n=57; root|Rep: Tyrosine-protein kinase transforming
protein Abl - Feline sarcoma virus (strain
Hardy-Zuckerman 2)
Length = 439
Score = 209 bits (511), Expect = 4e-52
Identities = 114/277 (41%), Positives = 164/277 (59%), Gaps = 14/277 (5%)
Query: 813 RPT--NVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKET 870
+PT V PN K + + ++ LG G +G+VY+GVW + + VA+K LKE
Sbjct: 171 KPTVYGVSPNYDKWEM-ERTDITMKHKLGGGQYGEVYEGVW----KKYSLTVAVKTLKED 225
Query: 871 TGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRT-HKEK 928
T +EFL+EA +M ++HPNL+QLL VC +IT+ M G L+DY+R ++++
Sbjct: 226 T--MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE 283
Query: 929 IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE 988
+ + L TQI+ M YLE+K +HRDLAARN LV + VK+ DFGL++L+ D
Sbjct: 284 VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDT 341
Query: 989 YKA-AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELI 1047
Y A AG K PIKW A E + + F+ KSDVWAFGV +WEI +YG PY I V EL+
Sbjct: 342 YTAHAGTKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL 401
Query: 1048 ENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
E ++ +P C +Y +M +CW + RP F ++
Sbjct: 402 EKDYRMERPEGCPEKVYELMRACWQWNPSDRPAFAEI 438
>UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=19;
Mammalia|Rep: Ephrin type-A receptor 1 precursor - Homo
sapiens (Human)
Length = 976
Score = 209 bits (510), Expect = 5e-52
Identities = 131/387 (33%), Positives = 196/387 (50%), Gaps = 16/387 (4%)
Query: 745 PYCSEHANDIPTATARTSTVLVIILVIASLFLAVLAIIG---YNFRQKAKAKKEAVKMTM 801
P+ +H +R T I+ VI L L ++G + R+ + +++ +
Sbjct: 526 PFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRA 585
Query: 802 VLTGCEDNEPLRP-----TNVKPNLAKLRIVKEAE---LRRGGMLGFGAFGKVYKGVWVP 853
ED L+P P L +E + L ++G G FG+VY+G
Sbjct: 586 TDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRL 645
Query: 854 EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQL 912
++ K VAIK LK+T+ FL EA IM HP++L L V + +M+IT+
Sbjct: 646 PSQDCKT-VAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEF 704
Query: 913 MPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVK 972
M G L ++R ++++ + IA GM YL VHRDLAARN+LV K
Sbjct: 705 MENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCK 764
Query: 973 ITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGA 1032
++DFGL +LLD + Y+ GGK+PI+W A E I HRIFT SDVW+FG+ +WE+LS+G
Sbjct: 765 VSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGD 824
Query: 1033 RPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMA 1092
+PY +S + V + IE+G +LP P C +Y +M +CW D RP F++L ++
Sbjct: 825 KPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLL 884
Query: 1093 RDPGRYLVIPG---DKFMRLPSYSTQD 1116
+P I +RLPS S D
Sbjct: 885 ANPHSLRTIANFDPRVTLRLPSLSGSD 911
>UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to
tyrosine-protein kinase pr2; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to tyrosine-protein
kinase pr2 - Nasonia vitripennis
Length = 1345
Score = 208 bits (509), Expect = 6e-52
Identities = 109/255 (42%), Positives = 157/255 (61%), Gaps = 10/255 (3%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG V +GVW +GE +I VAIK L N EFL+EA IM S++H ++++L
Sbjct: 180 LGTGEFGVVQQGVWTNDGE--RIQVAIKCLSRERMQNNPIEFLKEAAIMHSIDHEHIVRL 237
Query: 898 LAVCM-TNQMMLITQLMPLGCLVDYVR--THKEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
V + TN +ML+T+L PL L++ ++ + + + ++ QIA GM YLE KRL+
Sbjct: 238 YGVVLDTNSLMLVTELAPLRSLLECLKEPSLRASFPVPSLCDFSVQIADGMQYLEAKRLI 297
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA---AGGKMPIKWLALECIQHRIF 1011
HRDLAARN+LV + N VKI+DFGL++ L + +D Y+ K+PI W A ECI + F
Sbjct: 298 HRDLAARNILVFSKNKVKISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECISYLKF 357
Query: 1012 THKSDVWAFGVTIWEILSYGARPYENISARNVPELIE--NGLKLPQPSICTLDIYCVMVS 1069
T SDVWA+GVT+WE+ SYG +P+ ++ + E I+ N +L QP C D + +M
Sbjct: 358 TSASDVWAYGVTLWEMFSYGFQPWAALTGHQILEAIDEPNFQRLEQPDCCPKDYFSLMQQ 417
Query: 1070 CWMLDADSRPTFKQL 1084
CW + RP F +L
Sbjct: 418 CWQHEPTKRPKFSEL 432
>UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack CG14992-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to Ack
CG14992-PA - Apis mellifera
Length = 1302
Score = 208 bits (509), Expect = 6e-52
Identities = 104/269 (38%), Positives = 158/269 (58%), Gaps = 5/269 (1%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWV-PEGENVKIPVAIKVLKETTGANTSKEFLEEAY 884
++++ ++ LG G+FG V +G W P G K+PVA+KVLK + + F+ E
Sbjct: 104 LIQDKDVTLSDQLGDGSFGIVRRGEWTSPSGR--KLPVAVKVLKADAQPSVIENFVSEVQ 161
Query: 885 IMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARG 944
+M +++H NL++L V ++ MM++T+L LG L+DY+R +I ++ Q+A G
Sbjct: 162 VMHTLDHQNLIRLYGVVLSQPMMMVTELASLGALLDYLRKQCGQISVLTLCDYALQVATG 221
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWLAL 1003
MAYLE KR +HRDLA RNVL+ + + VKI DFGL + L ED Y + K+P W A
Sbjct: 222 MAYLEAKRFLHRDLACRNVLLSSIDKVKIGDFGLMRALPQQEDCYVMSEHKKVPFPWCAP 281
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE-NGLKLPQPSICTLD 1062
E ++ R FTH SDVW FGVT+WE+L++G P+ + + I+ G +L +P +
Sbjct: 282 ESLKRRKFTHASDVWMFGVTLWEMLTFGEEPWVGLKGSEILRKIDKEGERLHEPEATPPE 341
Query: 1063 IYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
+Y +M+ CW D RPTF L + M
Sbjct: 342 MYQLMLRCWACDPSERPTFASLRVSLTSM 370
>UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24;
Euteleostomi|Rep: Activated CDC42 kinase 1 - Homo sapiens
(Human)
Length = 1036
Score = 208 bits (508), Expect = 8e-52
Identities = 113/285 (39%), Positives = 158/285 (55%), Gaps = 7/285 (2%)
Query: 811 PLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVW-VPEGENVKIPVAIKVLKE 869
P P P + ++ E +LR LG G+FG V +G W P G+ V VA+K LK
Sbjct: 105 PGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVS--VAVKCLKP 162
Query: 870 T--TGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKE 927
+ +F+ E M S++H NL++L V +T M ++T+L PLG L+D +R H+
Sbjct: 163 DVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG 222
Query: 928 KIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINED 987
+ Q+A GM YLE KR +HRDLAARN+L+ T + VKI DFGL + L N+D
Sbjct: 223 HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDD 282
Query: 988 EY-KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPEL 1046
Y K+P W A E ++ R F+H SD W FGVT+WE+ +YG P+ ++ +
Sbjct: 283 HYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHK 342
Query: 1047 IE-NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
I+ G +LP+P C DIY VMV CW + RPTF L D E
Sbjct: 343 IDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLE 387
>UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like
tyrosine kinase CG3969-PA, isoform A; n=1; Apis
mellifera|Rep: PREDICTED: similar to Fak-like tyrosine
kinase CG3969-PA, isoform A - Apis mellifera
Length = 1270
Score = 207 bits (506), Expect = 1e-51
Identities = 116/301 (38%), Positives = 174/301 (57%), Gaps = 17/301 (5%)
Query: 799 MTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENV 858
+TM+ +D P+R N A IV + LG G FG V +GVW +GE
Sbjct: 90 LTMLPEERQDRPPIRVPNKHMIPADAIIVNKE-------LGTGEFGVVQQGVWTNDGE-- 140
Query: 859 KIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCM-TNQMMLITQLMPLGC 917
+I VAIK L N EFL+EA IM +++H ++++L V + TN +ML+T+L PL
Sbjct: 141 RIQVAIKCLSRERMQNNPIEFLKEAAIMYAIDHEHIVRLYGVVLDTNSLMLVTELAPLRS 200
Query: 918 LVDYVR--THKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITD 975
L++ ++ + + + ++ QIA GM YLE KRL+HRDLAARN+LV + N VKI+D
Sbjct: 201 LLECLKEPSLRSSFPVLSLCDFSVQIADGMQYLEAKRLIHRDLAARNILVFSKNKVKISD 260
Query: 976 FGLAKLLDINEDEYKA---AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGA 1032
FGL++ L + +D Y+ K+PI W A ECI + FT SDVWA+GVT+WE+ SYG
Sbjct: 261 FGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECISYLKFTSASDVWAYGVTLWEMFSYGF 320
Query: 1033 RPYENISARNVPELIE--NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
+P+ ++ + E I+ N +L QP C + + +M CW + RP F +L + +
Sbjct: 321 QPWAALTGHQILEAIDDPNFQRLEQPECCPKEYFSLMQQCWQHEPSKRPKFSELINLLPD 380
Query: 1091 M 1091
+
Sbjct: 381 L 381
>UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 206 bits (503), Expect = 3e-51
Identities = 106/273 (38%), Positives = 151/273 (55%), Gaps = 6/273 (2%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
+G G FG VYKG+W +P+A+K LK + +FL EA IM HPN+++L
Sbjct: 541 IGGGEFGTVYKGMW--NERKPPVPIAVKTLKPGSSDKMRDDFLTEASIMGQFHHPNVIKL 598
Query: 898 LAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
V M+I + M G L Y+R + EK+ + L +A GM YL E VHR
Sbjct: 599 YGVITKVEPAMIIMEFMDNGSLYYYLRHNDEKLSLQQLLKMACGVAAGMQYLSEVGYVHR 658
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQHRIFTHKS 1015
DLAARN+LV K+ DFGL++ + DEY GGK+P++W A E I +R FT S
Sbjct: 659 DLAARNILVSKDEVCKVADFGLSR--ETTNDEYDVKKGGKIPVRWTAPEAISYRKFTTAS 716
Query: 1016 DVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDA 1075
DVW++GV +WE++SYG +PYE+ + V + +E+G +L +P C +Y +M SCW +
Sbjct: 717 DVWSYGVLLWEVMSYGQQPYEDWDNQMVLDKLESGYRLQKPKDCPSTVYELMQSCWSAEH 776
Query: 1076 DSRPTFKQLADTFAEMARDPGRYLVIPGDKFMR 1108
RPTFK+L M + IP + R
Sbjct: 777 TDRPTFKELVRLLDAMLESNNKDAPIPKPRTRR 809
>UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep:
CG1511-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 1096
Score = 206 bits (503), Expect = 3e-51
Identities = 107/261 (40%), Positives = 149/261 (57%), Gaps = 2/261 (0%)
Query: 837 MLGFGAFGKVYKG-VWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLL 895
++G G FG V +G + +P I VAIK LK + +FL EA IM +HPN++
Sbjct: 746 IIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVI 805
Query: 896 QLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
L V +N +M+IT+ M G L ++R + K + + IA GM+YL + V
Sbjct: 806 YLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYV 865
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHK 1014
HRDLAARNVLV KI DFGL++ ++ D Y GGK+P++W A E I R FT
Sbjct: 866 HRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSA 925
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVW++GV +WE++SYG RPY N S ++V + IE G +LP P C +Y +M+ CW
Sbjct: 926 SDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQ 985
Query: 1075 ADSRPTFKQLADTFAEMARDP 1095
RPTF + T +AR P
Sbjct: 986 RTHRPTFASIVSTLDNLARQP 1006
>UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=32;
Euteleostomi|Rep: Ephrin type-A receptor 2 precursor -
Homo sapiens (Human)
Length = 976
Score = 206 bits (502), Expect = 4e-51
Identities = 128/386 (33%), Positives = 192/386 (49%), Gaps = 13/386 (3%)
Query: 723 TCPDNIPNKIYFDEQLQDPIEEPYCSEHANDIPTATARTSTVLVII--LVIASLFLAVLA 780
T D P+ Y + E ++ T + S L +I + + + L VLA
Sbjct: 493 TLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLA 552
Query: 781 IIGYNFRQKAKAKKEAVKMTMV-LTGCEDNEPLRP-----TNVKPNLAKLRIVKEAE--- 831
+G+ ++ K ++ V + E +PL+ T PN A L+ E
Sbjct: 553 GVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSC 612
Query: 832 LRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEH 891
+ R ++G G FG+VYKG+ ++PVAIK LK +FL EA IM H
Sbjct: 613 VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSH 672
Query: 892 PNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEE 950
N+++L V + MM+IT+ M G L ++R + + IA GM YL
Sbjct: 673 HNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLAN 732
Query: 951 KRLVHRDLAARNVLVQTPNSVKITDFGLAKLL-DINEDEYKAAGGKMPIKWLALECIQHR 1009
VHRDLAARN+LV + K++DFGL+++L D E Y +GGK+PI+W A E I +R
Sbjct: 733 MNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYR 792
Query: 1010 IFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVS 1069
FT SDVW+FG+ +WE+++YG RPY +S V + I +G +LP P C IY +M+
Sbjct: 793 KFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQ 852
Query: 1070 CWMLDADSRPTFKQLADTFAEMARDP 1095
CW + RP F + ++ R P
Sbjct: 853 CWQQERARRPKFADIVSILDKLIRAP 878
>UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13;
Euteleostomi|Rep: Activated CDC42 kinase 2 - Bos taurus
(Bovine)
Length = 747
Score = 206 bits (502), Expect = 4e-51
Identities = 109/270 (40%), Positives = 153/270 (56%), Gaps = 7/270 (2%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVW-VPEGENVKIPVAIKVLKET--TGANTSKEFLEE 882
++ E +L LG G+FG V +G W P G+ V VA+K LK + +F+ E
Sbjct: 120 LIGEKDLHLFEKLGDGSFGVVRRGEWDAPSGKTVS--VAVKCLKPDVLSQPEAMDDFIRE 177
Query: 883 AYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIA 942
M S++H NL++L V +T M ++T+L PLG L+D +R H+ + Q+A
Sbjct: 178 VNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVA 237
Query: 943 RGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWL 1001
GM YLE KR +HRDLAARN+L+ T + VKI DFGL + L N+D Y K+P W
Sbjct: 238 EGMGYLEAKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 297
Query: 1002 ALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE-NGLKLPQPSICT 1060
A E ++ R F+H SD W FGVT+WE+ +YG P+ ++ + I+ G +LP+P C
Sbjct: 298 APESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP 357
Query: 1061 LDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
DIY VMV CW + RPTF L D E
Sbjct: 358 QDIYNVMVQCWAHKPEDRPTFVALRDFLLE 387
>UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10;
Endopterygota|Rep: Tyrosine-protein kinase Btk29A -
Drosophila melanogaster (Fruit fly)
Length = 786
Score = 205 bits (501), Expect = 6e-51
Identities = 107/260 (41%), Positives = 157/260 (60%), Gaps = 13/260 (5%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG V +G W I A+K++KE G + +F+EEA +M ++HPNL+QL
Sbjct: 532 LGSGQFGVVRRGKW-----RGSIDTAVKMMKE--GTMSEDDFIEEAKVMTKLQHPNLVQL 584
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTH-KEKIGSKAFL-NWCTQIARGMAYLEEKRLV 954
VC ++ + ++T+ M G L++Y+R H K IG+ L + C Q+++GM YLE +
Sbjct: 585 YGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYI 644
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG-KMPIKWLALECIQHRIFTH 1013
HRDLAARN LV + N VK+ DFGLA+ + +D+Y ++GG K PIKW E + + F+
Sbjct: 645 HRDLAARNCLVGSENVVKVADFGLARY--VLDDQYTSSGGTKFPIKWAPPEVLNYTRFSS 702
Query: 1014 KSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWML 1073
KSDVWA+GV +WEI + G PY + V E ++ G+ L +P C +IY VM CW
Sbjct: 703 KSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSH 762
Query: 1074 DADSRPTFKQLADTFAEMAR 1093
+ RP F+ L D A +A+
Sbjct: 763 GPEERPAFRVLMDQLALVAQ 782
>UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27;
Fungi/Metazoa group|Rep: Tyrosine-protein kinase FRK -
Homo sapiens (Human)
Length = 505
Score = 205 bits (500), Expect = 8e-51
Identities = 106/251 (42%), Positives = 155/251 (61%), Gaps = 11/251 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG+V++G+W N PVA+K LK G+ +FL EA IM ++ HP L+QL
Sbjct: 240 LGSGQFGEVWEGLW-----NNTTPVAVKTLKP--GSMDPNDFLREAQIMKNLRHPKLIQL 292
Query: 898 LAVC-MTNQMMLITQLMPLGCLVDYVRTHK-EKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
AVC + + + +IT+LM G L +Y++ KI ++ Q+A GMAYLE + +H
Sbjct: 293 YAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIH 352
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDI-NEDEYKAAGG-KMPIKWLALECIQHRIFTH 1013
RDLAARNVLV N K+ DFGLA++ + NED Y++ K+P+KW A E I+ F+
Sbjct: 353 RDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSI 412
Query: 1014 KSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWML 1073
KSDVW+FG+ ++EI++YG PY ++ V +++ +LPQPS C Y +M+ CW
Sbjct: 413 KSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNA 472
Query: 1074 DADSRPTFKQL 1084
+ RPTF+ L
Sbjct: 473 EPKERPTFETL 483
>UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga
brevicollis|Rep: Receptor tyrosine kinase - Monosiga
brevicollis
Length = 1476
Score = 204 bits (499), Expect = 1e-50
Identities = 114/322 (35%), Positives = 179/322 (55%), Gaps = 16/322 (4%)
Query: 832 LRRGGMLGFGAFGKVYKGVWVPEGENVKIP-VAIKVLKETTGANTSKEFLEEAYIMASV- 889
+R G LG GAFG+V++ W+ + K+ A K LK ++FL E +M +
Sbjct: 726 VRLGEELGHGAFGEVFQA-WIRNSYSGKVRRCAAKTLKPDVSFEHRQDFLSEMTVMKEIG 784
Query: 890 EHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVR------THKEKIGSKAFLNWCTQIA 942
HPN++ ++ C+ +L+ +L G + DY+R + + I ++C QIA
Sbjct: 785 AHPNVIGIIGHCLRETPQILLVELAEFGNMRDYLRGCRATQENPQTIRVDQMADFCLQIA 844
Query: 943 RGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLA 1002
RGMA+LE+K ++HRDLAARNVLV KI+DFGLA+ I EYK K+P+KW+A
Sbjct: 845 RGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLAR--SIEGGEYKTTATKLPVKWMA 902
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLD 1062
E ++ RI+T KSDVW+FGVT+WEI S G PY+ R+V +E+G +LP P ++
Sbjct: 903 PESLKSRIYTTKSDVWSFGVTMWEIFSLGGTPYKEHQNRDVLSFLESGHRLPSPRQAPVE 962
Query: 1063 IYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIP---GDKFMR-LPSYSTQDEK 1118
+ CW+L+A RP+F +L D A++ + +P + F + S + E
Sbjct: 963 FDDIARMCWVLEASDRPSFSELVDLLADIVLEQSFSATVPEVDSENFYEAIAGPSEESEA 1022
Query: 1119 EMIRNLSSAMEGPESLVDADEY 1140
+R ++ ++ E+ + AD Y
Sbjct: 1023 SGLRAAANDVDDTEAWMGADMY 1044
>UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep: CG14992-PA
- Drosophila melanogaster (Fruit fly)
Length = 1073
Score = 204 bits (497), Expect = 2e-50
Identities = 105/271 (38%), Positives = 149/271 (54%), Gaps = 4/271 (1%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKET--TGANTSKEFLEEA 883
++ E ++ G LG G+FG V +G W IPVA+KVLK T +F E
Sbjct: 117 LIHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREV 176
Query: 884 YIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIAR 943
M +++H NL++L V ++ MM+IT+L G L+D +R NW QI
Sbjct: 177 QAMHALDHANLVRLYGVVLSQPMMMITELAERGSLLDTLRKQCRHTSLTIIWNWSVQIVT 236
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWLA 1002
GMAYLE+KR +HRDLA RNVL+ N +KI DFGL + L +D Y + K+P W A
Sbjct: 237 GMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCA 296
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE-NGLKLPQPSICTL 1061
E ++ R F+H SD W FGVT+WE+ S+G P+ ++ + I+ G +L QP C
Sbjct: 297 PESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPP 356
Query: 1062 DIYCVMVSCWMLDADSRPTFKQLADTFAEMA 1092
D+Y +M+ CW RPTF L + A M+
Sbjct: 357 DVYAMMLQCWDKTPAERPTFAALKEYLASMS 387
>UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Ephrin
receptor - Apis mellifera (Honeybee)
Length = 996
Score = 204 bits (497), Expect = 2e-50
Identities = 109/262 (41%), Positives = 147/262 (56%), Gaps = 3/262 (1%)
Query: 837 MLGFGAFGKVYKG-VWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLL 895
++G G FG V +G + +P +I VAIK LK + +FL EA IM EHPN++
Sbjct: 638 IIGGGEFGDVCRGKLKLPPDGRTEIDVAIKTLKPGSADKARNDFLTEASIMGQFEHPNVI 697
Query: 896 QLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
L V +N +M+IT+ M G L ++R + K + IA GM YL E V
Sbjct: 698 FLQGVVTKSNPVMIITEFMENGSLDTFLRANDGKFQVLQLVGMLRGIASGMQYLAEMNYV 757
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLD-INEDEYKAAGGKMPIKWLALECIQHRIFTH 1013
HRDLAARNVLV KI DFGL++ ++ E Y GGK+P++W A E I R FT
Sbjct: 758 HRDLAARNVLVNAALVCKIADFGLSREIESATEGAYTTRGGKIPVRWTAPEAIAFRKFTS 817
Query: 1014 KSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWML 1073
SDVW+ G+ WE++SYG RPY N S ++V + IE G +LP P C IY +M+ CW
Sbjct: 818 ASDVWSMGIVCWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEAIYQLMLDCWQK 877
Query: 1074 DADSRPTFKQLADTFAEMARDP 1095
+ RPTF L T ++ R P
Sbjct: 878 ERTHRPTFANLTQTLDKLIRSP 899
>UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n=11;
Metazoa|Rep: Tyrosine-protein kinase isoform SRK1 -
Spongilla lacustris (Freshwater sponge)
Length = 505
Score = 203 bits (496), Expect = 2e-50
Identities = 110/276 (39%), Positives = 168/276 (60%), Gaps = 16/276 (5%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+++ +++ LG G FG+V++G+W N VA+K LK G + +EFL+EA IM
Sbjct: 235 IEKTQIKLLRRLGAGQFGEVWEGLW-----NGTTSVAVKTLKP--GTMSVEEFLQEASIM 287
Query: 887 ASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGM 945
+ HP L+QL AVC + + ++T+LM G L++Y+R + + ++ Q+A GM
Sbjct: 288 KRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQLVDVAAQVASGM 347
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWLALE 1004
+YLE++ +HRDLAARN+LV K+ DFGLA+++D E+ Y+A G K PIKW A E
Sbjct: 348 SYLEQQNYIHRDLAARNILVGEHGICKVADFGLARVID--EEIYEAHTGAKFPIKWTAPE 405
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
+ FT KSDVW+FGV ++EI++YG PY ++ V E I+ ++P P+ C +
Sbjct: 406 AAMYNRFTIKSDVWSFGVVLYEIITYGRFPYPGMTNPEVLEKIQQNYRMPCPANCPKQFH 465
Query: 1065 CVMVSCWMLDADSRPTFK----QLADTF-AEMARDP 1095
+M+ CW D SRPTF+ QL + F +E RDP
Sbjct: 466 DIMLDCWREDPASRPTFETLQWQLEEFFNSEGYRDP 501
>UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2)
(EPH homology kinase 2).; n=2; Xenopus tropicalis|Rep:
Ephrin type-A receptor 6 precursor (EC 2.7.10.1)
(Tyrosine-protein kinase receptor EHK-2) (EPH homology
kinase 2). - Xenopus tropicalis
Length = 952
Score = 203 bits (495), Expect = 3e-50
Identities = 119/349 (34%), Positives = 188/349 (53%), Gaps = 12/349 (3%)
Query: 768 ILVIASLFLAVLAIIGYNFRQKAKAK-KEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRI 826
+LVI +LF + + + K K++ K V+ V T + + T P+LA
Sbjct: 525 LLVILTLFFLITGRCQWYIKAKMKSEEKRRVQFPGVKTYIDPD-----TYEDPSLAVHEF 579
Query: 827 VKEAE---LRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEA 883
KE + +R ++G G FG+V G + +IPVAIK LK K+FL EA
Sbjct: 580 AKEIDPSRIRIERVIGAGEFGEVCSGRLKTPAKK-EIPVAIKTLKGGYVDRQRKDFLREA 638
Query: 884 YIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIA 942
IM +HPN+++L V ++ +M++ + M G L ++R H + + IA
Sbjct: 639 SIMGQFDHPNIIRLEGVVTKSRPVMIVVEYMENGSLDSFLRKHDGQFTVIQLVGMLRGIA 698
Query: 943 RGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE-YKAAGGKMPIKWL 1001
GM YL + VHRDLAARN+LV + K++DFGL+++L+ + D Y GGK+PI+W
Sbjct: 699 SGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWT 758
Query: 1002 ALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTL 1061
A E I R F+ SD W++G+ +WE++SYG RPY +S ++V IE G +LP P C +
Sbjct: 759 APEAIAFRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPV 818
Query: 1062 DIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLP 1110
++ +M+ CW D + RP F + ++ R+P ++ D R+P
Sbjct: 819 SLHQLMLHCWQKDRNIRPKFSDIVGFLDKLIRNPSALHILVEDILGRMP 867
>UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=5; Euteleostomi|Rep: Chromosome 11
SCAF14979, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1042
Score = 203 bits (495), Expect = 3e-50
Identities = 105/282 (37%), Positives = 156/282 (55%), Gaps = 6/282 (2%)
Query: 819 PNLAKLRIVKEAE---LRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN+A + V E + + + ++G G FG+V++GV G+ ++ VAIK LK
Sbjct: 666 PNIAIQKFVTEIDPSAISKQKVIGVGEFGEVFRGVMKTRGQG-EVNVAIKTLKPGYSEKQ 724
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCMT-NQMMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
+FL EA IM HPN++ L V +M++T+ M G L Y++ +I
Sbjct: 725 RLDFLSEASIMGQFSHPNIIHLEGVVTKFKHIMIVTEYMDNGALDTYLKGRDGEIPPYQL 784
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL-DINEDEYKAAG 993
+ IA GM YL VHRDLAARN+LV + K++DFGL+++L D +E Y G
Sbjct: 785 VGMLRGIAAGMQYLSNMSYVHRDLAARNILVNSNLECKVSDFGLSRVLEDDDEGTYTTRG 844
Query: 994 GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKL 1053
GK+PI+W A E I +R FT SDVW+FG+ +WE++++G RPY ++S V + I +L
Sbjct: 845 GKIPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINEAFRL 904
Query: 1054 PQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
P P C IY +M+ CW D RP F + ++ R P
Sbjct: 905 PAPMDCPSAIYQLMLQCWQHDRSKRPRFSDIVSFLDKLLRSP 946
>UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whole
genome shotgun sequence; n=3; Tetraodontidae|Rep:
Chromosome undetermined SCAF14659, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 712
Score = 202 bits (494), Expect = 4e-50
Identities = 125/383 (32%), Positives = 198/383 (51%), Gaps = 16/383 (4%)
Query: 760 RTSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRP----- 814
+T+ +L + A++ L V+ ++ + R++ ++ + T + E +PL+
Sbjct: 273 KTAVILGAAVGGAAMLLIVVVVLLLHRRKRNPHIRQGPEDTY-FSSSEQLKPLKTYVDPH 331
Query: 815 TNVKPNLAKLRIVKE---AELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETT 871
T PN A ++ E + + + ++G G FG+VY+G+ G + VAIK LK
Sbjct: 332 TYEDPNTAVMKFATEIHPSHIAKEKVIGAGEFGEVYRGILKVPGRK-ESAVAIKTLKPGY 390
Query: 872 GANTSKEFLEEAYIMASVEHPNLLQLLAVCMT-NQMMLITQLMPLGCLVDYVRTHKEKIG 930
++FL EA IM H N+++L V M+IT+ M G L Y+R H +
Sbjct: 391 TEKQRQDFLSEASIMGQFAHQNIIRLEGVVTKFKHAMIITEYMENGALDRYLRDHDGEFT 450
Query: 931 SKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL-DINEDEY 989
S + IA GM YL + VHRDLAARN+LV K++DFGL+++L D E Y
Sbjct: 451 SFQLVGMLRGIAAGMKYLSDMSYVHRDLAARNILVNNTLECKVSDFGLSRVLEDDPEGTY 510
Query: 990 KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIEN 1049
+GGK+PI+W A E I +R F SDVW+FG+ +WE++++G RPY ++S V + I
Sbjct: 511 TTSGGKIPIRWTAPEAIAYRKFASASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINE 570
Query: 1050 GLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPG---DKF 1106
+LP P C +Y +M+ CW+ D RP F + + ++ R P I
Sbjct: 571 AFRLPAPMDCPSAVYQLMLQCWLHDRAKRPRFGDIVNLLDKLLRSPDSLKTIADFDPRVS 630
Query: 1107 MRLPSYSTQDEKEMIRNLSSAME 1129
+RLPS S D R++S +E
Sbjct: 631 IRLPSTSGSDGSP-FRSVSEWLE 652
>UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1048
Score = 202 bits (494), Expect = 4e-50
Identities = 130/376 (34%), Positives = 193/376 (51%), Gaps = 22/376 (5%)
Query: 749 EHANDIPTATARTSTVLVIILVIA--SLFLAVLAIIGYNFRQKA---KAKKEAVKMTMVL 803
E P T+ +II VI S+ +A++ I+ + R+K+ K+K + K+ M +
Sbjct: 542 ESTTSSPNTNDHVGTIQLIIAVIGGCSIVIAIVLIV-FCCRRKSHQNKSKLDMEKLPMFV 600
Query: 804 TGCEDNEPLR----------PTNVK-PNLAKLRIVKEAELRRGGM---LGFGAFGKVYKG 849
G N + PT + P A L KE + G+ +G G FG+V G
Sbjct: 601 MGHLKNGSIGYMPGHKTYIDPTTYEDPARAVLDFTKEIDASYIGIEEVIGGGEFGEVCLG 660
Query: 850 VWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQM-ML 908
+ VAIK LK +FL EA IM +HPN+++L V +Q M+
Sbjct: 661 RMRLPNSKKEHDVAIKTLKAGYSTQQKLDFLGEASIMGQFDHPNVIRLEGVVTKSQPHMI 720
Query: 909 ITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTP 968
IT+ M G L ++R H + + IA GM YL + VHRDLAARN+LV
Sbjct: 721 ITEYMENGSLDTFLRKHDGEFTVIQLVGILRNIAAGMKYLSDMGYVHRDLAARNILVNAQ 780
Query: 969 NSVKITDFGLAKLLDINEDE-YKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEI 1027
K++DFGL+++L+ + D Y GGK+PI+W A E I +R FT SDVW++G+ +WE+
Sbjct: 781 LICKVSDFGLSRVLEESSDSTYTTRGGKIPIRWTAPEAINYRKFTSASDVWSYGIVMWEV 840
Query: 1028 LSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADT 1087
+SYG RPY +S ++V + G +LP P C + +M+ CW D + RP F Q+ T
Sbjct: 841 MSYGERPYWGMSNQDVIHAVGTGYRLPAPMDCPQVQHELMLDCWKKDRNERPKFSQVVAT 900
Query: 1088 FAEMARDPGRYLVIPG 1103
M R+P + VI G
Sbjct: 901 LDRMIREPEQLKVIAG 916
>UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Danio
rerio|Rep: Spleen protein tyrosine kinase - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 586
Score = 202 bits (493), Expect = 5e-50
Identities = 102/248 (41%), Positives = 151/248 (60%), Gaps = 5/248 (2%)
Query: 836 GMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLK-ETTGANTSKEFLEEAYIMASVEHPNL 894
G LG G FG V +GV+ + + + VA+K+LK + A E L EA +M +++P +
Sbjct: 326 GELGSGNFGTVLRGVY--QMKKTQKVVAVKILKNDDDNAAVKDEMLREANVMQQLDNPYI 383
Query: 895 LQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
++++ +C +ML+ +L LG L +++ +K I K Q++ GM YLEE V
Sbjct: 384 VRMIGICEAENLMLVMELAELGPLHKFLQKNKH-ITVKNLTELVHQVSMGMKYLEEHNFV 442
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAG-GKMPIKWLALECIQHRIFTH 1013
HRDLAARNVL+ T + KI+DFGL+K L +E+ YKA G GK P+KW A EC+ + F+
Sbjct: 443 HRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHGKWPLKWYAPECMNYLKFSS 502
Query: 1014 KSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWML 1073
KSDVW+FGV +WE SYG +PY+ + V ++IENG ++ P C ++Y +M CW
Sbjct: 503 KSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLMKKCWTY 562
Query: 1074 DADSRPTF 1081
D RP F
Sbjct: 563 KPDERPGF 570
>UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 780
Score = 202 bits (493), Expect = 5e-50
Identities = 103/273 (37%), Positives = 162/273 (59%), Gaps = 3/273 (1%)
Query: 825 RIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAY 884
R ++ + ++ ++G G FG+V G G+ IPVA+K LK ++FL EA
Sbjct: 408 REIEASRIKIEKIIGSGEFGEVCYGRMRLPGKR-DIPVALKTLKVGYTEKQKRDFLAEAS 466
Query: 885 IMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIAR 943
IMA +HPN+++L V ++ +M+IT+ M G L ++R H + + IA
Sbjct: 467 IMAQFDHPNVIRLEGVVTHSKPVMIITEYMENGSLDSFLRRHDGQFTIIQLVGLLRGIAA 526
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE-YKAAGGKMPIKWLA 1002
GM YL + +HRDLAARN+LV + K++DFGL+++L+ + D Y +GGK+PI+W A
Sbjct: 527 GMTYLSDLGYIHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTSGGKIPIRWTA 586
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLD 1062
E I R F+ SDVW++GV +WE+ SYG RPY N++ R+V + +E G +LP P C
Sbjct: 587 PEAITFRKFSSSSDVWSYGVVMWEVTSYGERPYWNLTNRDVIKSVEEGYRLPAPMGCPAA 646
Query: 1063 IYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
++ +M+ CW D + RP F Q+ ++ R+P
Sbjct: 647 LHTLMLDCWQKDRNERPRFCQIVTVLDKLIRNP 679
>UniRef50_UPI00015B5A01 Cluster: PREDICTED: similar to protein kinase
protein; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to protein kinase protein - Nasonia vitripennis
Length = 1337
Score = 202 bits (492), Expect = 7e-50
Identities = 110/311 (35%), Positives = 173/311 (55%), Gaps = 8/311 (2%)
Query: 787 RQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLR-IVKEAELRRGGMLGFGAFGK 845
++K A+ + +T + G + R + N + L ++++ ++ LG G+FG
Sbjct: 93 KKKRTAQWKKSLITKIRPGSDKKSNKRASQPVENASVLTCLIQDKDVTLSVKLGDGSFGV 152
Query: 846 VYKGVWV-PEGENVKIPVAIKVLKETT--GANTSKEFLEEAYIMASVEHPNLLQLLAVCM 902
V +G W P G +PVA+KVLK N ++F+ E M ++H NL++L V +
Sbjct: 153 VRRGEWTSPTGRT--LPVAVKVLKADALNQPNVVEDFVSEVQSMHMLDHHNLIRLYGVVL 210
Query: 903 TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARN 962
+ MM++T+L PLG L+DY+R I N+ Q+A GMAYLE KR +HRDLA RN
Sbjct: 211 SQPMMMVTELAPLGALLDYLRKQCGHISVLTLCNYALQVATGMAYLEAKRFLHRDLACRN 270
Query: 963 VLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWLALECIQHRIFTHKSDVWAFG 1021
VL+ + + +KI DFGL + L ED Y K+P W A E ++ R F+H SDVW FG
Sbjct: 271 VLLSSVDKIKIGDFGLMRALPQQEDCYVMTEHKKVPFPWCAPESLKARQFSHASDVWMFG 330
Query: 1022 VTIWEILSYGARPYENISARNVPELIE-NGLKLPQPSICTLDIYCVMVSCWMLDADSRPT 1080
VT+WE+L++G P+ ++ + + I+ G +L +P ++ +M+ CW D RPT
Sbjct: 331 VTLWEMLTFGEEPWVGLNGSEILKKIDREGERLHEPEASPPAMFQLMLHCWARDPAERPT 390
Query: 1081 FKQLADTFAEM 1091
F L ++ M
Sbjct: 391 FASLKESLTGM 401
>UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA;
n=3; Tribolium castaneum|Rep: PREDICTED: similar to
CG14992-PA - Tribolium castaneum
Length = 1000
Score = 201 bits (491), Expect = 9e-50
Identities = 105/308 (34%), Positives = 169/308 (54%), Gaps = 7/308 (2%)
Query: 787 RQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLR--IVKEAELRRGGMLGFGAFG 844
+++A+ +K + ++ L+ T+ LA ++ E+ + LG G+FG
Sbjct: 64 KKRAQIRKRNLINKLIPVVANKTATLKKTDDSVTLADFTSCLIPESNITLSIKLGDGSFG 123
Query: 845 KVYKGVWVPEGENVKIPVAIKVLKETTGANTS--KEFLEEAYIMASVEHPNLLQLLAVCM 902
V +G W V +PVA+K+LK + ++F++E M + HPNL++L V +
Sbjct: 124 VVRRGEWTSPNGRV-LPVAVKILKADALSQPGVFEDFIKEVQAMHVLSHPNLIRLYGVVL 182
Query: 903 TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARN 962
+ MM++T+L LG L+DY+R ++ + TQ+A GMAYLE KR +HRDLA RN
Sbjct: 183 SQPMMMVTELANLGSLLDYLRKQCQQTPVPMLCEYATQVATGMAYLESKRFLHRDLACRN 242
Query: 963 VLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWLALECIQHRIFTHKSDVWAFG 1021
VL+ + + +KI DFGL + L ED Y K+P W A E ++ R F+H SD W FG
Sbjct: 243 VLLASADKIKIGDFGLMRALPQEEDCYVMTEHKKVPFPWCAPESLRSRQFSHASDTWMFG 302
Query: 1022 VTIWEILSYGARPYENISARNVPELIE-NGLKLPQPSICTLDIYCVMVSCWMLDADSRPT 1080
VT+WE+ ++G P+ + + I+ G +L QP C +Y +++ CW+ + RPT
Sbjct: 303 VTVWEMFTFGEDPWMGLIGSEILRKIDKEGERLHQPEACPPAVYSILLQCWLKNPTERPT 362
Query: 1081 FKQLADTF 1088
F L + F
Sbjct: 363 FAALKEFF 370
>UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep: Zgc:154019
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 732
Score = 201 bits (491), Expect = 9e-50
Identities = 108/268 (40%), Positives = 157/268 (58%), Gaps = 7/268 (2%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVW-VPEGENVKIPVAIKVLKETTGANTSKEFLEEAY 884
++++ EL G LG G+FG V K W P G +PVA+K L+ + +FL+E
Sbjct: 105 LIQDRELLFGDRLGSGSFGVVRKAEWHTPTGR--VLPVAVKTLRSGQ-VDLVSDFLQEVT 161
Query: 885 IMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRT-HKEKIGSKAFLNWCTQIAR 943
M S++HPN++ L V +T+ + ++T+L PLG L D +R H E S+ +L + TQIA
Sbjct: 162 SMQSLDHPNIIHLYGVVLTHPLKMVTELAPLGSLYDTLRLRHGEYPLSRLWL-FSTQIAA 220
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLAL 1003
GM YLE +R +HRDLAARNVL+ VKI DFGL + LD + A ++P W A
Sbjct: 221 GMEYLESRRFIHRDLAARNVLLAAREQVKIGDFGLMRGLDDRDHYIMTAHRRIPFAWCAP 280
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE-NGLKLPQPSICTLD 1062
E ++ F+H SDVW FGVT+WE+ +Y P+ +S R + +E G +L +P C +
Sbjct: 281 ESLRTGSFSHASDVWMFGVTLWEMFTYCEEPWLGLSGRQILYRVEREGERLERPPDCPQE 340
Query: 1063 IYCVMVSCWMLDADSRPTFKQLADTFAE 1090
+Y VM CW ++ RPTF QL +E
Sbjct: 341 LYAVMRKCWACNSTERPTFAQLTTMVSE 368
>UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep:
MBRTK2 - Monosiga brevicollis
Length = 759
Score = 201 bits (490), Expect = 1e-49
Identities = 122/336 (36%), Positives = 181/336 (53%), Gaps = 19/336 (5%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
V+ +R G LG GAFG+V++ + + A K LK ++FL E +M
Sbjct: 355 VERRSVRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKALKPGAPFRARQDFLSEMTVM 414
Query: 887 ASV-EHPNLLQLLAVCMTNQM-MLITQLMPLGCLVDYVR---THKEK---IGSKAFLNWC 938
+ HPN++ + C+ ++ +L+ +L LG L DY+R T + K +GS+ ++C
Sbjct: 415 KEIGAHPNIIGIFGHCLRDEPHILLVELAELGNLRDYLRKCRTSQSKPQLLGSRQLADFC 474
Query: 939 TQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPI 998
QIA GM++LE K ++HRDLAARNVL+ + KI DFGLA+ ++ NED Y+ K+P+
Sbjct: 475 LQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARSIE-NED-YETTATKLPV 532
Query: 999 KWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSI 1058
KW+A E + +RI+T KSDVW+FGVT+WEI S G PY ++ L+ +G +LP+P
Sbjct: 533 KWMAPESLGYRIYTSKSDVWSFGVTMWEIFSLGGTPYVKHRNVDILSLLADGYRLPKPRQ 592
Query: 1059 CTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIP---GDKFMRLPSYSTQ 1115
+ CWM +AD+RPTF +L D R L P D T+
Sbjct: 593 APGQADAIARMCWMHEADNRPTFLELVDLLTAFIRKKNFSLAEPEVDSDGLYEAIGDPTE 652
Query: 1116 D-EKEMIRNLSSAMEGP-----ESLVDADEYLQPKF 1145
D E IR + S EG ES ++ DE +F
Sbjct: 653 DSEGSGIRAIMSGTEGMGAGIYESQINGDEIYDNEF 688
>UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47;
Euteleostomi|Rep: Protein tyrosine kinase 2 beta - Homo
sapiens (Human)
Length = 1009
Score = 201 bits (490), Expect = 1e-49
Identities = 96/255 (37%), Positives = 157/255 (61%), Gaps = 2/255 (0%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
+LG G FG+VY+GV+ + KI VA+K K+ + ++F+ EA IM +++HP++++
Sbjct: 430 ILGEGFFGEVYEGVYTNH-KGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVK 488
Query: 897 LLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
L+ + +I +L P G L Y+ +K + + + QI + MAYLE VHR
Sbjct: 489 LIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHR 548
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSD 1016
D+A RN+LV +P VK+ DFGL++ ++ +ED YKA+ ++PIKW++ E I R FT SD
Sbjct: 549 DIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVTRLPIKWMSPESINFRRFTTASD 607
Query: 1017 VWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDAD 1076
VW F V +WEILS+G +P+ + ++V ++E G +LP+P +C +Y +M CW D
Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667
Query: 1077 SRPTFKQLADTFAEM 1091
RP F +L + +++
Sbjct: 668 DRPRFTELVCSLSDV 682
>UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep: Eph
receptor B1 - Mus musculus (Mouse)
Length = 943
Score = 200 bits (489), Expect = 2e-49
Identities = 103/261 (39%), Positives = 158/261 (60%), Gaps = 5/261 (1%)
Query: 839 GFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLL 898
G G FG+VYKG G+ +I VAIK LK ++FL EA IM +HPN+++L
Sbjct: 585 GRGEFGEVYKGRLKLPGKR-EIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 643
Query: 899 AVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRD 957
V ++ +M+IT+ M G L ++R + + + IA GM YL E VHRD
Sbjct: 644 GVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRD 703
Query: 958 LAARNVLVQTPNSVKITDFGLAKLL--DINEDEYKAA-GGKMPIKWLALECIQHRIFTHK 1014
LAARN+LV + K++DFGL++ L D ++ Y ++ GGK+P++W A E I +R FT
Sbjct: 704 LAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSA 763
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVW++G+ +WE++S+G RPY ++S ++V IE +LP P C ++ +M+ CW D
Sbjct: 764 SDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKD 823
Query: 1075 ADSRPTFKQLADTFAEMARDP 1095
+SRP F ++ +T +M R+P
Sbjct: 824 RNSRPRFAEIVNTLDKMIRNP 844
>UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa
group|Rep: Src family kinase - Asterina miniata (Bat
star) (Patiria miniata)
Length = 563
Score = 200 bits (489), Expect = 2e-49
Identities = 108/250 (43%), Positives = 152/250 (60%), Gaps = 13/250 (5%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG+V++G W N + VA+K LKE GA FL+EA IM + HP L+ L
Sbjct: 308 LGNGQFGEVWEGTW-----NGTVRVAVKTLKE--GAMDPTAFLQEANIMKKLRHPKLVAL 360
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEK-IGSKAFLNWCTQIARGMAYLEEKRLVH 955
LAVC + + ++T+LM GCL+DY+ + K + ++ Q+A GMAYLE +R VH
Sbjct: 361 LAVCSEGEPIYIVTELMTNGCLLDYLHEGEGKQLREPELIDITAQVADGMAYLESQRFVH 420
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQHRIFTHK 1014
RDLAARN+LV + K+ DFGL++++ EDEY A G KMPIKW A E I FT K
Sbjct: 421 RDLAARNILVGDLRNCKVADFGLSRII---EDEYIAKEGAKMPIKWTAPEAINFGKFTIK 477
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVW+FG+ I+E+++ G PY + R V + + G ++P+P C +Y + CW
Sbjct: 478 SDVWSFGILIYEVITKGRVPYPGMVNREVLDQVSRGYRMPKPPECPDQLYDITKQCWDAV 537
Query: 1075 ADSRPTFKQL 1084
+ RPTF+ L
Sbjct: 538 PEKRPTFEFL 547
>UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5;
Caenorhabditis|Rep: Tyrosine-protein kinase abl-1 -
Caenorhabditis elegans
Length = 1224
Score = 200 bits (489), Expect = 2e-49
Identities = 112/272 (41%), Positives = 151/272 (55%), Gaps = 11/272 (4%)
Query: 816 NVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
++ PN + +E+ LG G +G VY+G W + +A+K LKE A
Sbjct: 295 SLSPNAPDEWELDRSEIIMHNKLGGGQYGDVYEGYW----KRHDCTIAVKALKED--AMP 348
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVR-THKEKIGSKA 933
EFL EA IM + H NL++LL VC +IT+ M G L++Y+R T K +
Sbjct: 349 LHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPII 408
Query: 934 FLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-A 992
+ +QIA GM+YLE + +HRDLAARN LV N VKI DFGLA+ + ED Y A A
Sbjct: 409 LVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFM--KEDTYTAHA 466
Query: 993 GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLK 1052
G K PIKW A E + F+ KSDVWAFGV +WEI +YG PY + NV L+ENG +
Sbjct: 467 GAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFR 526
Query: 1053 LPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
+ P C +Y +M+ CW RP F+ +
Sbjct: 527 MDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDI 558
>UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3; Culicidae|Rep:
Protein kinase protein - Aedes aegypti (Yellowfever
mosquito)
Length = 1081
Score = 200 bits (488), Expect = 2e-49
Identities = 103/278 (37%), Positives = 154/278 (55%), Gaps = 5/278 (1%)
Query: 813 RPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTG 872
R T LA ++ E ++ LG G+FG V +G W G + +PVA+K+LK T
Sbjct: 100 RETEEPSALALTCLIHEKDVTMSVKLGDGSFGVVRRGEWNAPGGQI-VPVAVKILKADTL 158
Query: 873 ANTS--KEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIG 930
A ++F +E M ++ HPNL++L V ++ MM++T+L G L+D +R +
Sbjct: 159 AQPGVIEDFFKEVQAMHTLNHPNLVRLHGVVLSQPMMMVTELAANGSLLDTLRKQCKNTS 218
Query: 931 SKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY- 989
NW Q+A GMAYLE KR +HRDLA RNVL+ + N +KI DFGL + L ED Y
Sbjct: 219 LTTIWNWSVQVATGMAYLESKRFLHRDLACRNVLLASGNKIKIGDFGLMRALPQQEDCYV 278
Query: 990 KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE- 1048
K+P W A E +++R F+H SD W F VT+WE+ ++G P+ ++ + I+
Sbjct: 279 MTEHKKVPFPWCAPESLRYRQFSHASDTWMFAVTLWEMFTFGEDPWVGLNGSQILRKIDR 338
Query: 1049 NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
G +L P C D+Y +M+ CW RPTF + +
Sbjct: 339 EGERLHHPDACPPDVYQLMLQCWDKSPAERPTFAAIKE 376
>UniRef50_A7RL50 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 438
Score = 200 bits (488), Expect = 2e-49
Identities = 102/273 (37%), Positives = 164/273 (60%), Gaps = 8/273 (2%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGA---NTSKEFLEE 882
++ E+ L M+G GAFG V KG W + K+ VA+K LK + A +F++E
Sbjct: 110 LITESSLVLYEMIGDGAFGYVRKGQWTTD-TGTKVDVAVKCLKFSADAAFIQMQTDFIKE 168
Query: 883 AYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIA 942
A MA ++HP++++L + ++ MML+T+L PLGCL+ +R ++++ ++ Q+A
Sbjct: 169 ANSMALLDHPHIIRLFGIVLSTPMMLVTELAPLGCLLTALRNNRQRFMVSTLCDFMIQVA 228
Query: 943 RGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWL 1001
GMAYLE KR +HRDLAARNVL+++ VKI DFGL + L + +D Y GK+P W
Sbjct: 229 SGMAYLESKRFIHRDLAARNVLLESNEKVKIGDFGLMRALSVEDDYYTMNPKGKVPFAWC 288
Query: 1002 ALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGL-KLP-QPSIC 1059
E +++R F+H SDVW+FG+ + E+ SYG P+ ++ + ++ L + P +PS C
Sbjct: 289 PPEALKYRKFSHASDVWSFGICVIELFSYGEEPWPGLNGAQILAKVDMPLCERPLKPSHC 348
Query: 1060 TLDIYCVMVS-CWMLDADSRPTFKQLADTFAEM 1091
IY ++VS CW D +R F +L + ++
Sbjct: 349 PSLIYSLLVSLCWAHDPSNRAGFSELKKSLEQV 381
>UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54;
Gnathostomata|Rep: Tyrosine-protein kinase BTK - Homo
sapiens (Human)
Length = 659
Score = 200 bits (488), Expect = 2e-49
Identities = 103/256 (40%), Positives = 151/256 (58%), Gaps = 11/256 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG V G W G+ VAIK++KE G+ + EF+EEA +M ++ H L+QL
Sbjct: 408 LGTGQFGVVKYGKW--RGQ---YDVAIKMIKE--GSMSEDEFIEEAKVMMNLSHEKLVQL 460
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
VC + + +IT+ M GCL++Y+R + + ++ L C + M YLE K+ +HR
Sbjct: 461 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 520
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQHRIFTHKS 1015
DLAARN LV VK++DFGL++ + +DEY ++ G K P++W E + + F+ KS
Sbjct: 521 DLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKS 578
Query: 1016 DVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDA 1075
D+WAFGV +WEI S G PYE + E I GL+L +P + + +Y +M SCW A
Sbjct: 579 DIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKA 638
Query: 1076 DSRPTFKQLADTFAEM 1091
D RPTFK L ++
Sbjct: 639 DERPTFKILLSNILDV 654
>UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to CG8250-PA
- Tribolium castaneum
Length = 1284
Score = 200 bits (487), Expect = 3e-49
Identities = 132/432 (30%), Positives = 222/432 (51%), Gaps = 35/432 (8%)
Query: 757 ATARTSTVLVIILVIASLFLAVL-AIIGYNFRQKAKAKKEAVKMTMVLTGCE-DNEPLRP 814
A ++ ++I+L+I+ +FL L A I + + + + + +L+G + + LR
Sbjct: 728 AAGDATSWILIVLIISVIFLTTLVAFICFILYNRYQHQASGILRRKMLSGADLQLDRLRV 787
Query: 815 ------TNVKPN---------LAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEG-ENV 858
T PN L L+ + +LR LG GAFG+VY+G + + V
Sbjct: 788 ASDSMMTEYNPNYEFGGVVYTLKDLKDIPREQLRLVKALGQGAFGEVYQGFYRQRPCDTV 847
Query: 859 KIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGC 917
++PVA+K L E + + +FL EA IM+ HPN++ + VC ++ +L+ G
Sbjct: 848 EMPVAVKTLPEMSTSQAEMDFLMEALIMSKFNHPNIVHFIGVCFDKHPRFIVLELLAGGD 907
Query: 918 LVDYVRTHKEK------IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNS- 970
L +++R + K + K + +A+G YLE+ R +HRD+AARN L+ T
Sbjct: 908 LKNFLRESRPKPERGSPLTMKDLVLIAVDVAKGCKYLEDNRFIHRDIAARNCLLTTKGPG 967
Query: 971 --VKITDFGLAKLLDINEDEYKAAGGK--MPIKWLALECIQHRIFTHKSDVWAFGVTIWE 1026
VKI DFG+++ D+ +Y GGK +PIKW+ E IFT K+DVW+FGV +WE
Sbjct: 968 RVVKIADFGMSR--DVYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGVLLWE 1025
Query: 1027 ILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
I+S G PY + R V +L+ +G +L P+ C IY +M CW + RPTF + +
Sbjct: 1026 IMSMGYMPYTGCANREVMQLVTSGGRLDPPANCPGPIYGIMTQCWHPTPEQRPTFATILE 1085
Query: 1087 TFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDADEYLQPKFK 1146
+DP + + P F R P S + + ++R LSS + + + +YL P
Sbjct: 1086 RLGYCLQDP-QVMNAPLPVFNRPP--SNERDATVMRPLSSDENCLQVVPQSSDYLIPNHT 1142
Query: 1147 SMTGTVTTNSAL 1158
+++ + ++S++
Sbjct: 1143 NVSNPIGSSSSV 1154
>UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF14482, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 621
Score = 200 bits (487), Expect = 3e-49
Identities = 104/290 (35%), Positives = 166/290 (57%), Gaps = 6/290 (2%)
Query: 808 DNEPLRPTNVKPNLAKLRIVKEAEL-RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKV 866
D E P+ + V ++L G LG G FG V KG++ + + + VA+K+
Sbjct: 332 DTEVYESPYADPDELRSSTVDRSQLFLEDGELGSGNFGTVMKGIY--KMKKTEKTVAVKI 389
Query: 867 LK-ETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTH 925
LK + + +E L EA +M +++P +++++ +C +ML+ +L LG L +++ H
Sbjct: 390 LKNDEDNLSVREEMLREANVMQQLDNPYIVRMIGICEAENLMLVMELAELGPLHKFLQKH 449
Query: 926 KEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDIN 985
K+ I K Q++ GM YLEE VHRDLAARNVL+ T + KI+DFGL+K + +
Sbjct: 450 KQ-ISMKNITELVHQVSVGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKAVAED 508
Query: 986 EDEYKAAG-GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVP 1044
+ YKA G GK P+KW A ECI + F+ KSDVW+FGV +WE S+G +PY+ + V
Sbjct: 509 KSYYKAKGHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSFGQKPYKGMKGNEVM 568
Query: 1045 ELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
++IE+G ++ P+ C ++ +M +CW + RP+F + E D
Sbjct: 569 QMIESGQRMEAPANCPSEMSDLMQACWTYKVEDRPSFSVVEPRLREYYYD 618
>UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18;
Euteleostomi|Rep: Tyrosine-protein kinase ITK/TSK - Homo
sapiens (Human)
Length = 620
Score = 200 bits (487), Expect = 3e-49
Identities = 102/269 (37%), Positives = 156/269 (57%), Gaps = 11/269 (4%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYI 885
++ +EL +G G FG V+ G W+ + + VAIK ++E GA + ++F+EEA +
Sbjct: 357 VIDPSELTFVQEIGSGQFGLVHLGYWLNKDK-----VAIKTIRE--GAMSEEDFIEEAEV 409
Query: 886 MASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARG 944
M + HP L+QL VC+ + L+ + M GCL DY+RT + ++ L C + G
Sbjct: 410 MMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEG 469
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG-KMPIKWLAL 1003
MAYLEE ++HRDLAARN LV +K++DFG+ + + +D+Y ++ G K P+KW +
Sbjct: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRF--VLDDQYTSSTGTKFPVKWASP 527
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDI 1063
E ++ KSDVW+FGV +WE+ S G PYEN S V E I G +L +P + + +
Sbjct: 528 EVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHV 587
Query: 1064 YCVMVSCWMLDADSRPTFKQLADTFAEMA 1092
Y +M CW + RP F +L AE+A
Sbjct: 588 YQIMNHCWKERPEDRPAFSRLLRQLAEIA 616
>UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family
protein tyrosine kinase; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to src-family protein
tyrosine kinase - Strongylocentrotus purpuratus
Length = 387
Score = 199 bits (486), Expect = 4e-49
Identities = 108/254 (42%), Positives = 153/254 (60%), Gaps = 12/254 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG+V++GVW N PVA+K LKE T + + FL EA +M + H ++QL
Sbjct: 132 LGEGKFGEVWQGVW-----NGNTPVAVKTLKERTMSPAA--FLAEANVMKKLRHEGIVQL 184
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEK-IGSKAFLNWCTQIARGMAYLEEKRLVH 955
AVC + + ++T+LM G L Y+++ K K ++ IA GM YL K +VH
Sbjct: 185 YAVCSDKEPIYIVTELMSNGDLRTYLKSDKCKNTKMTTLIDMGAHIASGMDYLGSKNVVH 244
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQHRIFTHK 1014
RDLAARNVLV N VKI DFG A+L++ +D Y G K+P+KW A E + H FT K
Sbjct: 245 RDLAARNVLVGKGNVVKIADFGRAQLME--KDVYVGEEGAKLPLKWTAPEAVLHGRFTIK 302
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVW+FG+ + E++++G PY+ + R V + + NG ++P+ CT +Y +M+ CW D
Sbjct: 303 SDVWSFGILMTEMVTFGGYPYKKMRTREVTKKVANGYRMPKMDHCTDSLYMIMLKCWHKD 362
Query: 1075 ADSRPTFKQLADTF 1088
RPTFK L D F
Sbjct: 363 PQQRPTFKYLHDYF 376
>UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome shotgun
sequence; n=3; Fungi/Metazoa group|Rep: Chromosome 3
SCAF14978, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 958
Score = 199 bits (486), Expect = 4e-49
Identities = 98/260 (37%), Positives = 162/260 (62%), Gaps = 5/260 (1%)
Query: 835 GGMLGFGAFGKVYKGVWVPE-GENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPN 893
G +LG G FG+V+ GV+ + GEN+ VAIK K + A+ ++FL EA +M +++HP+
Sbjct: 390 GQILGEGFFGEVHNGVYKTQTGENLS--VAIKTCKNCS-ADVKEKFLSEASVMKNLDHPH 446
Query: 894 LLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRL 953
+++L+ V + + ++ +L G L Y+ + + + + +C QI + +AYLE +
Sbjct: 447 IVRLIGVIEADPVWIVMELYEHGELGKYLVEQQYSLTTVMLITYCLQICKALAYLEGLNV 506
Query: 954 VHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTH 1013
VHRD+A RN+LV +P VK+ DFGL++ ++ E+ YKA+ ++PIKW+A E I R FT
Sbjct: 507 VHRDIAVRNILVASPLCVKLGDFGLSRYIE-EEEYYKASASRLPIKWMAPESINFRRFTT 565
Query: 1014 KSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWML 1073
SDVW FGV +WEI S +P+ + V + +E+G++LP+P +C +Y ++ SCW
Sbjct: 566 ASDVWMFGVCVWEIFSMAQQPFFWLENSQVIDQLESGIRLPKPQLCPPTVYSLVSSCWSH 625
Query: 1074 DADSRPTFKQLADTFAEMAR 1093
+ RP F LA + +E+ R
Sbjct: 626 EPHLRPQFSHLACSLSEIHR 645
>UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep: Ephrin
receptor - Mus musculus (Mouse)
Length = 819
Score = 198 bits (484), Expect = 7e-49
Identities = 127/359 (35%), Positives = 192/359 (53%), Gaps = 18/359 (5%)
Query: 748 SEHANDIPTATARTSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMT-----MV 802
S + IP A + TV VI+L + FL GY+ KAK E KM +
Sbjct: 404 SNDQSQIPII-AVSVTVGVILLAVMIGFLLSGRRCGYS---KAKQDPEEEKMHFHNGHIK 459
Query: 803 LTGCEDNEPLRP-TNVKPNLAKLRIVKEAE---LRRGGMLGFGAFGKVYKGVWVPEGENV 858
L G + P T PN A KE E + ++G G FG+V G G+
Sbjct: 460 LPGVRTY--IDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKR- 516
Query: 859 KIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGC 917
++PVAIK LK ++FL EA IM +HPN++ L V ++ +M++T+ M G
Sbjct: 517 ELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGS 576
Query: 918 LVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFG 977
L +++ + + + IA GM YL + VHRDLAARN+L+ + K++DFG
Sbjct: 577 LDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFG 636
Query: 978 LAKLL-DINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYE 1036
L+++L D E Y GGK+PI+W A E I R FT SDVW++G+ +WE++SYG RPY
Sbjct: 637 LSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVMWEVVSYGERPYW 696
Query: 1037 NISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
++ ++V + +E G +LP P C +Y +M+ CW D +SRP F ++ + ++ R+P
Sbjct: 697 EMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNMLDKLIRNP 755
>UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55;
Euteleostomi|Rep: Tyrosine-protein kinase ZAP-70 - Homo
sapiens (Human)
Length = 619
Score = 198 bits (483), Expect = 9e-49
Identities = 100/245 (40%), Positives = 147/245 (60%), Gaps = 3/245 (1%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG V +GV+ +I VAIKVLK+ T ++E + EA IM +++P +++L
Sbjct: 344 LGCGNFGSVRQGVY--RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401
Query: 898 LAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRD 957
+ VC +ML+ ++ G L ++ +E+I Q++ GM YLEEK VHRD
Sbjct: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461
Query: 958 LAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWLALECIQHRIFTHKSD 1016
LAARNVL+ + KI+DFGL+K L ++ Y A + GK P+KW A ECI R F+ +SD
Sbjct: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521
Query: 1017 VWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDAD 1076
VW++GVT+WE LSYG +PY+ + V IE G ++ P C ++Y +M CW+ +
Sbjct: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581
Query: 1077 SRPTF 1081
RP F
Sbjct: 582 DRPDF 586
>UniRef50_Q7PT15 Cluster: ENSANGP00000009263; n=2; Culicidae|Rep:
ENSANGP00000009263 - Anopheles gambiae str. PEST
Length = 1306
Score = 198 bits (482), Expect = 1e-48
Identities = 106/256 (41%), Positives = 150/256 (58%), Gaps = 11/256 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG V +GVW E +I VAIK L + EFL+EA +M S+EH N+++L
Sbjct: 126 LGTGEFGIVQQGVWTNGSE--RIQVAIKCLCRERMQSNPMEFLKEAAMMHSIEHENIVRL 183
Query: 898 LAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWC---TQIARGMAYLEEKRL 953
V + T +ML+T+L L L++ ++ ++ C +QI GM YLE KR
Sbjct: 184 YGVVLDTESLMLVTELAHLRSLLECLKDPGLRVSFLTVPTLCEFASQICNGMMYLENKRF 243
Query: 954 VHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA---AGGKMPIKWLALECIQHRI 1010
+HRDLAARN+LV + N VKI+DFGL++ L + +D Y+ K+PI W A ECI
Sbjct: 244 IHRDLAARNILVFSKNKVKISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECINFLR 303
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE--NGLKLPQPSICTLDIYCVMV 1068
FTH SDVWAFGV +WEI SYG +P+ ++ + E I+ + +L +P C + Y +M+
Sbjct: 304 FTHASDVWAFGVCLWEIFSYGFQPWAALTGHQILEAIDEPHYQRLEKPECCPKEYYALML 363
Query: 1069 SCWMLDADSRPTFKQL 1084
CW DA RP F +
Sbjct: 364 KCWQHDAAKRPKFSDI 379
>UniRef50_Q9UK79 Cluster: Herstatin; n=1; Homo sapiens|Rep:
Herstatin - Homo sapiens (Human)
Length = 419
Score = 197 bits (481), Expect = 2e-48
Identities = 118/320 (36%), Positives = 168/320 (52%), Gaps = 25/320 (7%)
Query: 1 MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKV 60
+ +P++ +TH LR + C V GNLELT+L + LSFL+ I+EV GYVLI+H +V
Sbjct: 33 LRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNA-SLSFLQDIQEVQGYVLIAHNQV 91
Query: 61 HKIVLPQLQIIRGRTLFKLN----VREEEFALLVTMSTAFT-------LELPALRDVLQG 109
++ L +L+I+RG LF+ N V + L T L+L +L ++L+G
Sbjct: 92 RQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKG 151
Query: 110 SVGIYSNFNLCHVKTINWDEINQDLTQVTFTFIILPLGKG--NARVVTQPAR-WAAGESI 166
V I N LC+ TI W +I Q+ T I + + + +R W GES
Sbjct: 152 GVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCW--GESS 209
Query: 167 ENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQE 226
E+CQ ++T+C+ CA RC GP P DCC+ CA GCTGP + CLAC +F G C
Sbjct: 210 EDCQSLTRTVCAGGCA--RCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELH 267
Query: 227 CPSMQIYNPTTYSWEPNPNGKYAYGATCVRNCP-EHLLKDNGACVRSCPPNKTAVNGE-- 283
CP++ YN T+ PNP G+Y +GA+CV CP +L D G+C CP + V E
Sbjct: 268 CPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDG 327
Query: 284 ---CIPCVGTCPKTCRAEKP 300
C C C + + P
Sbjct: 328 TQRCEKCSKPCARGTHSLPP 347
Score = 70.9 bits (166), Expect = 2e-10
Identities = 37/132 (28%), Positives = 49/132 (37%), Gaps = 14/132 (10%)
Query: 418 GAIAIMENRNLCYADKIAWNKLVKSKDHKQI-IQKNGDPRQCEKNNLVCDPQCSADGCWG 476
G + I N LCY D I W + + + + R C C P C CWG
Sbjct: 151 GGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHP----CSPMCKGSRCWG 206
Query: 477 PGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCTGASRANCTSCKH 536
+ C S +C C+ G D C CH +C GCTG ++C +C H
Sbjct: 207 ESSEDCQSLTR----TVCAGGCARCKGPLPTD---C--CHEQCAAGCTGPKHSDCLACLH 257
Query: 537 VRDGPYCVAQCP 548
C CP
Sbjct: 258 FNHSGICELHCP 269
Score = 38.3 bits (85), Expect = 1.5
Identities = 22/71 (30%), Positives = 29/71 (40%), Gaps = 6/71 (8%)
Query: 630 RKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECK-GC 688
R CHP C G + + C R C C + +C CH +C GC
Sbjct: 190 RACHPCSPMCKGSRCWGESSEDCQSLTR-TVCAGGCA--RCKGPLPTDC--CHEQCAAGC 244
Query: 689 TGPGPTDCIKC 699
TGP +DC+ C
Sbjct: 245 TGPKHSDCLAC 255
>UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=22;
Euteleostomi|Rep: Ephrin type-A receptor 8 precursor -
Homo sapiens (Human)
Length = 1005
Score = 197 bits (481), Expect = 2e-48
Identities = 102/273 (37%), Positives = 154/273 (56%), Gaps = 3/273 (1%)
Query: 825 RIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAY 884
R ++ + + ++G G G+V G G+ +PVAIK LK ++FL EA
Sbjct: 628 REIEASRIHIEKIIGSGDSGEVCYGRLRVPGQR-DVPVAIKALKAGYTERQRRDFLSEAS 686
Query: 885 IMASVEHPNLLQLLAVCMTNQM-MLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIAR 943
IM +HPN+++L V ++ M++T+ M G L ++RTH + + +
Sbjct: 687 IMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGA 746
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE-YKAAGGKMPIKWLA 1002
GM YL + VHRDLAARNVLV + K++DFGL+++L+ + D Y GGK+PI+W A
Sbjct: 747 GMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTA 806
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLD 1062
E I R F+ SDVW+FGV +WE+L+YG RPY N++ R+V +E G +LP P C
Sbjct: 807 PEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHA 866
Query: 1063 IYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
++ +M+ CW D RP F Q+ + R P
Sbjct: 867 LHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSP 899
>UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56; n=15;
Sophophora|Rep: Focal adhesion kinase homolog DFak56 -
Drosophila melanogaster (Fruit fly)
Length = 1200
Score = 197 bits (480), Expect = 2e-48
Identities = 90/232 (38%), Positives = 138/232 (59%)
Query: 860 IPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLV 919
I VAIK K ++ FL EAYIM +HP++++L+ +C + ++ +L LG L
Sbjct: 508 IQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELR 567
Query: 920 DYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLA 979
Y++T+ E++ L +C Q++ ++YLE K+ VHRD+AARNVLV +P VK+ DFGL+
Sbjct: 568 AYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLS 627
Query: 980 KLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENIS 1039
+ + + +PIKW++ E I R FT SDVW FGV IWEIL G +P++ +
Sbjct: 628 RWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVK 687
Query: 1040 ARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
+V +ENG +LP P C +Y +M CW + RP FK++ +T E+
Sbjct: 688 NSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEI 739
>UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=311;
Eumetazoa|Rep: Ephrin type-B receptor 2 precursor - Homo
sapiens (Human)
Length = 1055
Score = 197 bits (480), Expect = 2e-48
Identities = 108/284 (38%), Positives = 164/284 (57%), Gaps = 8/284 (2%)
Query: 819 PNLAKLRIVKEAEL---RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN A KE ++ + ++G G FG+V G G+ +I VAIK LK
Sbjct: 605 PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKR-EIFVAIKTLKSGYTEKQ 663
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
++FL EA IM +HPN++ L V + +M+IT+ M G L ++R + +
Sbjct: 664 RRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQL 723
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL--DINEDEYKAA 992
+ IA GM YL + VHRDLAARN+LV + K++DFGL++ L D ++ Y +A
Sbjct: 724 VGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSA 783
Query: 993 -GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGL 1051
GGK+PI+W A E IQ+R FT SDVW++G+ +WE++SYG RPY +++ ++V IE
Sbjct: 784 LGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDY 843
Query: 1052 KLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
+LP P C ++ +M+ CW D + RP F Q+ +T +M R+P
Sbjct: 844 RLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP 887
>UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|Rep:
Focal adhesion kinase - Aedes aegypti (Yellowfever
mosquito)
Length = 1092
Score = 196 bits (479), Expect = 3e-48
Identities = 92/232 (39%), Positives = 141/232 (60%), Gaps = 1/232 (0%)
Query: 860 IPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLV 919
I VA+K K TS++FLEEAYIM EHP++++L+ +C + + ++ +L LG L
Sbjct: 483 IQVAVKTCKADADLATSEKFLEEAYIMQKFEHPHIIKLIGICSGSPIWIVMELARLGELR 542
Query: 920 DYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLA 979
Y++ + K+ L + Q++ ++YLE K+ VHRD+AARNVLV +P +K+ DFGL+
Sbjct: 543 AYLKKNGSKLKLGTLLLYSYQLSTALSYLESKKFVHRDIAARNVLVSSPTCIKLADFGLS 602
Query: 980 KLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENIS 1039
+ ++ ++ Y + G +PIKW+A E I R FT SDVW FGV WEIL G +P++ I
Sbjct: 603 RWVE-DQSYYTSTKGMLPIKWMAPESINFRRFTTASDVWMFGVCTWEILMLGVKPFQGIK 661
Query: 1040 ARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
+V +ENG +LP P C +Y +M CW + RP FK + + E+
Sbjct: 662 NCDVIGKLENGERLPLPPNCPPRLYSLMSQCWSYEPHKRPNFKNIKEVLYEI 713
>UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
Cek8 - Strongylocentrotus purpuratus
Length = 775
Score = 196 bits (477), Expect = 5e-48
Identities = 101/270 (37%), Positives = 150/270 (55%), Gaps = 3/270 (1%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+ ++R ++G G FG V G+ + + I VA+K LK +FL EA IM
Sbjct: 412 IDATQIRILEVIGGGEFGDVCSGLMLMP-DKTTIKVAVKTLKTGATDKDRSDFLSEASIM 470
Query: 887 ASVEHPNLLQLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGM 945
+HPN+++LL V T M++T+ M G L Y+R + + L + GM
Sbjct: 471 GQFDHPNVIKLLGVVTKTRPAMIVTEFMENGSLDKYLRENDGRFTVTQLLGMMRGVGFGM 530
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALEC 1005
+L E VHRDLAARN+LV K+ DFGL++ ++ + Y+ GGK+PI+W A E
Sbjct: 531 RFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKEL-DGAYETRGGKIPIRWTAPEA 589
Query: 1006 IQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYC 1065
I ++ FT SDVW+ GV +WEI+SYG RPY N ++V + +E G +LP P C I+
Sbjct: 590 IGYKKFTSASDVWSLGVVMWEIMSYGERPYWNWPNQDVIKAVEKGYRLPPPMECPEAIHQ 649
Query: 1066 VMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
+M+ CW D + RPTF + T + R+P
Sbjct: 650 LMLDCWQRDRNHRPTFTTIVSTLDRLIRNP 679
>UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1006
Score = 196 bits (477), Expect = 5e-48
Identities = 105/280 (37%), Positives = 161/280 (57%), Gaps = 12/280 (4%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
++G G FG+V G +G+ +I VAIK LK ++FL EA IM +HPN+++
Sbjct: 666 VIGMGEFGEVCSGRLRVQGKR-EIYVAIKSLKAGYSDKQRRDFLSEASIMGQFDHPNIIR 724
Query: 897 LLAVCMT-NQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
L V +M+IT+ M G L ++R H + + IA GM YL + VH
Sbjct: 725 LEGVVTRCKPLMIITEYMENGSLDAFLRKHDGQFTVIQLVGMLRGIASGMKYLSDMSYVH 784
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDI----------NEDEYKAAGGKMPIKWLALEC 1005
RDLAARN+LV + K++DFGL+++L+ N Y + GGK+PI+W A E
Sbjct: 785 RDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRENTGTYLSPGGKIPIRWTAPEA 844
Query: 1006 IQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYC 1065
I +R FT SDVW++G+ +WE++SYG RPY +++ ++V + IE G +LP P C L ++
Sbjct: 845 IAYRKFTTASDVWSYGIVMWEVVSYGERPYWDMNNQDVIKAIEEGYRLPAPMDCPLVLHQ 904
Query: 1066 VMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDK 1105
+M+ CW + RPTF Q+ + ++ R+PG GD+
Sbjct: 905 LMLDCWERERAERPTFSQILNMLDKLIRNPGTLRRTGGDR 944
>UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6;
Eumetazoa|Rep: Tyrosine kinase receptor ron - Canis
familiaris (Dog)
Length = 998
Score = 196 bits (477), Expect = 5e-48
Identities = 105/281 (37%), Positives = 165/281 (58%), Gaps = 15/281 (5%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
++G G FG VY G ++ E +N +I A+K L T ++ FL E +M + HPN+L
Sbjct: 685 VIGKGHFGVVYHGEYIDEDQN-RIHCAVKSLSRITEVQEAEAFLREGLLMRGLHHPNVLA 743
Query: 897 LLAVCMTNQMM--LITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
L+ + + + + ++ M G L+ ++R+ + K +++ Q+ARGM YL E++ V
Sbjct: 744 LIGIVLPPEGLPRVLLPYMRHGDLLRFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFV 803
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAG----GKMPIKWLALECIQHRI 1010
HRDLAARN ++ +VK+ DFGLA+ DI + EY + ++P+KW+ALE +Q
Sbjct: 804 HRDLAARNCMLDESFTVKVADFGLAR--DILDKEYYSVRQHRHARLPVKWMALESLQTYR 861
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
FT KSDVW+FGV +WE+L+ GA PY +I ++ + + G +LPQP C +Y VM C
Sbjct: 862 FTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLIQFLAQGRRLPQPEYCPNSLYMVMQRC 921
Query: 1071 WMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPS 1111
W +D RPTF L + +A R L GD +++LP+
Sbjct: 922 WAVDPAVRPTFTALVEEVEHVA---ARLL---GDHYVQLPA 956
>UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 485
Score = 196 bits (477), Expect = 5e-48
Identities = 100/269 (37%), Positives = 157/269 (58%), Gaps = 13/269 (4%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSK-EFLEEAYI 885
+ +A L + ++G G FG+V+ G + EG+ V A+K +K+ +K +FL EA +
Sbjct: 221 IPKASLLKKSLIGKGEFGEVWLGDY--EGKKV----AMKSMKDHLKDEKAKTQFLAEASV 274
Query: 886 MASVEHPNLLQLLAVCMT-NQMMLITQLMPLGCLVDYVRTHKEKIGSKAF-LNWCTQIAR 943
M ++ HPNL+ L+ + + N + LIT+ M G L+DY+R+ + +K +++ + +
Sbjct: 275 MTTLRHPNLVCLIGISLDDNPIYLITEFMAKGSLIDYLRSRGRAVITKQNQIDFARDVVK 334
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLAL 1003
GM YLE + VHRDLAARNVL+ N K++DFGLAK + K G K+P+KW A
Sbjct: 335 GMVYLESQNFVHRDLAARNVLIAEDNVAKVSDFGLAK----SSSNVKQEGAKLPVKWTAP 390
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDI 1063
E ++ F++K+DVW+FGV +WEI SYG PY + +V +ENG ++ P C I
Sbjct: 391 EALRENKFSNKTDVWSFGVLLWEIYSYGRVPYPRVPVEDVANHVENGYRMESPDGCPDQI 450
Query: 1064 YCVMVSCWMLDADSRPTFKQLADTFAEMA 1092
Y +M+ CW D RP F ++ +A
Sbjct: 451 YKIMMDCWEKDPSQRPNFTRIEKALESVA 479
>UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome shotgun
sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 4
SCAF14752, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 810
Score = 195 bits (476), Expect = 6e-48
Identities = 98/270 (36%), Positives = 157/270 (58%), Gaps = 8/270 (2%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYI 885
I+ ++ G +LG G FG+V+KG + K PVA+K KE + FL EA I
Sbjct: 546 ILNHEDVVLGELLGKGNFGEVFKGTL----QRDKTPVAVKTCKEDLPSELKIRFLSEARI 601
Query: 886 MASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARG 944
+ +HPN+++L+ VC Q + ++ +L+P G + Y+R K+++ +K L + A G
Sbjct: 602 LKQYDHPNIVKLIGVCTQRQPIYIVMELVPGGDFLSYLRKKKDELKTKQLLRFAVDAAAG 661
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGK-MPIKWLAL 1003
MAYLE K +HRDLAARN LV N++KI+DFG+++ D + Y ++G K +PIKW A
Sbjct: 662 MAYLESKNCIHRDLAARNCLVGDNNALKISDFGMSRQED--DGIYSSSGLKQIPIKWTAP 719
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDI 1063
E + + ++ +SDVW++G+ +WE S G PY ++ + E +E G ++ P C D+
Sbjct: 720 EALNYGRYSSESDVWSYGILLWETFSLGMCPYPGMTNQQAREQVEKGYRMACPQRCPDDV 779
Query: 1064 YCVMVSCWMLDADSRPTFKQLADTFAEMAR 1093
Y VM CW + + RP F +L A + +
Sbjct: 780 YKVMQRCWQYNPEDRPKFSELQRDLAAVKK 809
>UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n=4;
Caenorhabditis|Rep: Protein kinase protein 32, isoform a
- Caenorhabditis elegans
Length = 867
Score = 195 bits (476), Expect = 6e-48
Identities = 108/303 (35%), Positives = 168/303 (55%), Gaps = 8/303 (2%)
Query: 784 YNFRQKAKAKKEAVKMTMVLTGCEDN-EPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGA 842
YN R K + ++ LT E P P N+ N+ R+ +E + ++G G
Sbjct: 323 YNQRDSV-FKLKGIERCETLTMHEATIRPKTPNNIDSNI---RLRREL-ITLKELIGGGQ 377
Query: 843 FGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCM 902
FG VYK V+ ++ +I VA+KV K ++ L+E+ +M + H N++QL+ VC+
Sbjct: 378 FGNVYKAVYHDLEKDERIAVAVKVCKTDAEPADTQLILQESSLMRNFRHSNIIQLIGVCV 437
Query: 903 TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARN 962
M L+ +L P G L +Y++ K+ + + +C+QI + YL R VHRD+AARN
Sbjct: 438 DQPMWLVLELAPKGELREYLQQEKDWLPLRILTLFCSQICDSLVYLHSTRFVHRDIAARN 497
Query: 963 VLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGV 1022
+LV +P VK+ DFGL++ LD + Y A+ GK+PIKWLA E + +R F+ SDVW FGV
Sbjct: 498 ILVCSPQCVKLADFGLSRALDY-DAVYTASRGKLPIKWLAPESVNYRQFSMASDVWMFGV 556
Query: 1023 TIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY-CVMVSCWMLDADSRPTF 1081
+WEI S G +P+ ++ +V IE G + P P C +Y + W ++ RPT
Sbjct: 557 CMWEIFSLGVKPWAGVTNSDVIMHIEQGSRPPCPEKCPTALYNFIRSKMWAIEPHKRPTV 616
Query: 1082 KQL 1084
Q+
Sbjct: 617 DQI 619
>UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23;
Theria|Rep: Tyrosine-protein kinase SYK - Homo sapiens
(Human)
Length = 635
Score = 195 bits (475), Expect = 8e-48
Identities = 106/276 (38%), Positives = 160/276 (57%), Gaps = 12/276 (4%)
Query: 808 DNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVL 867
D E +RP V + KL +++ EL G G FG V KG + + + V VA+K+L
Sbjct: 354 DPEEIRPKEVYLD-RKLLTLEDKEL------GSGNFGTVKKGYY--QMKKVVKTVAVKIL 404
Query: 868 K-ETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHK 926
K E E L EA +M +++P +++++ +C ML+ ++ LG L Y++ ++
Sbjct: 405 KNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR 464
Query: 927 EKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINE 986
+ K + Q++ GM YLEE VHRDLAARNVL+ T + KI+DFGL+K L +E
Sbjct: 465 H-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 523
Query: 987 DEYKA-AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPE 1045
+ YKA GK P+KW A ECI + F+ KSDVW+FGV +WE SYG +PY + V
Sbjct: 524 NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583
Query: 1046 LIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTF 1081
++E G ++ P+ C ++Y +M CW D ++RP F
Sbjct: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619
>UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=51;
Euteleostomi|Rep: Ephrin type-A receptor 7 precursor -
Homo sapiens (Human)
Length = 998
Score = 195 bits (475), Expect = 8e-48
Identities = 104/282 (36%), Positives = 161/282 (57%), Gaps = 6/282 (2%)
Query: 819 PNLAKLRIVKEAE---LRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN A + KE + ++ ++G G FG+V G G+ + VAIK LK
Sbjct: 617 PNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKR-DVAVAIKTLKVGYTEKQ 675
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
++FL EA IM +HPN++ L V + +M++ + M G L ++R H +
Sbjct: 676 RRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQL 735
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL-DINEDEYKAAG 993
+ IA GM YL + VHRDLAARN+LV + K++DFGL++++ D E Y G
Sbjct: 736 VGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTG 795
Query: 994 GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKL 1053
GK+P++W A E IQ+R FT SDVW++G+ +WE++SYG RPY ++S ++V + IE G +L
Sbjct: 796 GKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRL 855
Query: 1054 PQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
P P C ++ +M+ CW + RP F+Q+ +M R+P
Sbjct: 856 PAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNP 897
>UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=2; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 1071
Score = 194 bits (474), Expect = 1e-47
Identities = 111/308 (36%), Positives = 172/308 (55%), Gaps = 10/308 (3%)
Query: 819 PNLAKLRIVKEAEL---RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN A KE ++ + ++G G FG+V G G+ +I VAIK LK
Sbjct: 708 PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGNLRQPGKR-EILVAIKTLKVGYTERQ 766
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
++FL EA IM +HPN++ L V ++ +M+IT+ M G L ++R + +
Sbjct: 767 RRDFLSEASIMGQFDHPNIIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQL 826
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL--DINEDEYKAA 992
+ IA G+ YL + VHRDLAARN+LV + K++DFGL++ L D ++ Y +A
Sbjct: 827 VGMLRGIAAGVKYLCDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSA 886
Query: 993 -GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGL 1051
GGK+PI+W A E IQ+R FT SD W++G+ +WE++SYG RPY ++S ++V IE
Sbjct: 887 LGGKIPIRWTAPEAIQYRKFTSSSDCWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDY 946
Query: 1052 KLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPG--RYLVIPGDKFMRL 1109
+LP P C ++ +M+ CW + ++RP F Q+ T +M R+P + +
Sbjct: 947 RLPPPMDCPSALHQLMLDCWQKERNNRPKFSQIVSTLDKMIRNPNSLKAMTPLSSSTPDF 1006
Query: 1110 PSYSTQDE 1117
S+ST DE
Sbjct: 1007 SSFSTVDE 1014
>UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1072
Score = 194 bits (474), Expect = 1e-47
Identities = 106/282 (37%), Positives = 160/282 (56%), Gaps = 6/282 (2%)
Query: 819 PNLAKLRIVKEAE---LRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN A KE + +R ++G G FG+V G +G+ +I VAIK LK
Sbjct: 707 PNQAIRDFAKEIDASNIRIERVIGAGEFGEVCSGRLRVQGKR-EIYVAIKSLKAGYSDKQ 765
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCMT-NQMMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
++FL EA IM +HPN+++L V +M+IT+ M G L +++ H +
Sbjct: 766 RRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIITEFMENGSLDTFLKKHDGQFTVIQL 825
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL-DINEDEYKAAG 993
+ IA GM YL + VHRDLAARN+LV + K++DFGL+++L D E Y G
Sbjct: 826 VGMLRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRG 885
Query: 994 GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKL 1053
GK+PI+W A E I +R FT SDVW++G+ +WE++SYG RPY +S ++V + I+ G +L
Sbjct: 886 GKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAIDEGYRL 945
Query: 1054 PQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
P P C + ++ +M+ CW RP F Q+ ++ R+P
Sbjct: 946 PAPMDCPVVLHQLMLDCWEKGRSDRPKFGQIVTILDKLIRNP 987
>UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=103;
Euteleostomi|Rep: Ephrin type-A receptor 5 precursor -
Homo sapiens (Human)
Length = 1037
Score = 194 bits (474), Expect = 1e-47
Identities = 102/282 (36%), Positives = 162/282 (57%), Gaps = 6/282 (2%)
Query: 819 PNLAKLRIVKEAE---LRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN A KE E + ++G G FG+V G G+ ++PVAIK LK
Sbjct: 659 PNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKR-ELPVAIKTLKVGYTEKQ 717
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
++FL EA IM +HPN++ L V ++ +M++T+ M G L +++ + +
Sbjct: 718 RRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQL 777
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL-DINEDEYKAAG 993
+ I+ GM YL + VHRDLAARN+L+ + K++DFGL+++L D E Y G
Sbjct: 778 VGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 837
Query: 994 GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKL 1053
GK+PI+W A E I R FT SDVW++G+ +WE++SYG RPY ++ ++V + +E G +L
Sbjct: 838 GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRL 897
Query: 1054 PQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
P P C +Y +M+ CW + +SRP F ++ + ++ R+P
Sbjct: 898 PSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNP 939
>UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 276
Score = 194 bits (473), Expect = 1e-47
Identities = 106/266 (39%), Positives = 165/266 (62%), Gaps = 17/266 (6%)
Query: 837 MLGFGAFGKVYKGVWV-PEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-EHPNL 894
+LG GAFG+V+KG+ P G+ IPVA+K LK +EF+ E +M +V +H N+
Sbjct: 2 LLGEGAFGQVFKGILRGPNGQ--VIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNI 59
Query: 895 LQLLAVCMTNQMM-LITQLMPLGCLVDYVRT-HKEK-----IGSKAFLNWCTQIARGMAY 947
+ + CM Q+ +I + +P G L Y++ KEK I SK FL++ QIA GMA+
Sbjct: 60 VTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACGMAH 119
Query: 948 LEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWLALECI 1006
LE ++HRDLAARN+LV T +KI+DFG+++ Y K + G +P++WL+ E I
Sbjct: 120 LESVGIIHRDLAARNILVGTGKVLKISDFGMSR-----PGVYIKMSKGVIPLRWLSPEAI 174
Query: 1007 QHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCV 1066
+ +++KSDVWAFGV +WEI + G PY N++ +++ + G++L QP+ C+ D+Y +
Sbjct: 175 KDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYIL 234
Query: 1067 MVSCWMLDADSRPTFKQLADTFAEMA 1092
M SCW L A+ RP+F + ++A
Sbjct: 235 MKSCWNLKAEDRPSFLAILSKIEQIA 260
>UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: Eph
receptor - Manduca sexta (Tobacco hawkmoth) (Tobacco
hornworm)
Length = 1011
Score = 194 bits (473), Expect = 1e-47
Identities = 113/310 (36%), Positives = 160/310 (51%), Gaps = 6/310 (1%)
Query: 792 AKKEAVKMTMVLTGCEDNEPLRP-TNVKPNLAKLRIVKEAE---LRRGGMLGFGAFGKVY 847
AK + T + G + P T PN A +E + + ++G G FG V
Sbjct: 603 AKTSSNATTPLFAGTGSRTYIDPHTYEDPNQAVREFAREIDASCITIEAIIGGGEFGDVC 662
Query: 848 KGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMT-NQM 906
+G +I VAIK LK + ++FL EA IM EHPN++ L V N +
Sbjct: 663 RGKLKLASCGQEIDVAIKTLKPGSTERARRDFLAEASIMGQFEHPNVIFLQGVVTKCNPI 722
Query: 907 MLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQ 966
M+IT+ M G L ++R + K + IA GM YL E +HRDLAARNVLV
Sbjct: 723 MIITEFMENGSLDTFLRANDGKFMVLQLVGMLRGIATGMQYLSEMNYIHRDLAARNVLVN 782
Query: 967 TPNSVKITDFGLAKLLDINED-EYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIW 1025
+ KI DFGL++ ++ D Y GGK+P++W A E I R FT SDVW+ G+ W
Sbjct: 783 SHLVCKIADFGLSREIESTADGAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSMGIVCW 842
Query: 1026 EILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLA 1085
E++S+G RPY N S ++V + IE G +LP P C +Y +M+ CW + RPTF +
Sbjct: 843 EVMSFGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEAVYQLMLDCWQKERTHRPTFASIV 902
Query: 1086 DTFAEMARDP 1095
T ++ P
Sbjct: 903 KTLDKLIGYP 912
>UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|Rep:
Tyrosine kinase receptor - Xenopus laevis (African clawed
frog)
Length = 1369
Score = 194 bits (472), Expect = 2e-47
Identities = 95/257 (36%), Positives = 150/257 (58%), Gaps = 9/257 (3%)
Query: 834 RGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPN 893
R ++G G FG VY G +V E + ++ A+K L T +EFL E +M S HPN
Sbjct: 1059 RDRIIGKGHFGSVYHGTYVDEDQQ-EVHCAVKSLNRITDLEEVEEFLREGILMKSFHHPN 1117
Query: 894 LLQLLAVCMTNQ--MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEK 951
+L L+ +C+ + +++ M G L ++R+ + K + + Q++RGM YL +
Sbjct: 1118 VLSLIGICLPQEGLPLVVLPFMKHGDLRHFIRSEERNPTVKDLVGFGLQVSRGMEYLANR 1177
Query: 952 RLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA----GGKMPIKWLALECIQ 1007
+ VHRDLAARN ++ VK+ DFGLA+ D+ + EY + ++P+KW+A+E +Q
Sbjct: 1178 KFVHRDLAARNCMLDESFHVKVADFGLAR--DVFDKEYYSVRRHKNARLPVKWMAMESLQ 1235
Query: 1008 HRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVM 1067
+ FT KSDVW+FGV +WE+++ GA PY ++ A ++ + G +L QP C +Y +M
Sbjct: 1236 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVDAYDITRYLFRGRRLAQPEYCPNPLYSLM 1295
Query: 1068 VSCWMLDADSRPTFKQL 1084
+SCW RPTF QL
Sbjct: 1296 LSCWNPQPVERPTFTQL 1312
>UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n=2;
Danio rerio|Rep: UPI00015A61DF UniRef100 entry - Danio
rerio
Length = 985
Score = 193 bits (471), Expect = 2e-47
Identities = 93/251 (37%), Positives = 159/251 (63%), Gaps = 5/251 (1%)
Query: 835 GGMLGFGAFGKVYKGVWVPE-GENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPN 893
G +LG G FG+V+ G++ + GE V VA+K K+ + A+ ++F+ EA IM ++HP+
Sbjct: 365 GRILGEGFFGEVHDGIYKSKSGERVN--VAVKTCKDCS-ADVKEKFMSEALIMKKLDHPH 421
Query: 894 LLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRL 953
+++L+ + + + ++ +L P G L +Y++ ++ K+ + + + QI++ +AYLE +
Sbjct: 422 IVRLIGIIEEDPVWIVMELYPFGELENYLKDNQNKLTNVTLILYSLQISKALAYLEGVNM 481
Query: 954 VHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTH 1013
VHRD+A RNVLV + VK+ DFGL++ ++ E+ YKA+ ++PIKW+A E I R FT
Sbjct: 482 VHRDIAVRNVLVAKVDCVKLGDFGLSRYIE-EEEYYKASVTRLPIKWMAPESINFRRFTS 540
Query: 1014 KSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWML 1073
SDVW F V +WEI+S G +P+ + ++V +E G++LP+P C +Y +M CW
Sbjct: 541 ASDVWMFAVCMWEIMSGGQQPFFWLENKDVINQLEQGMRLPKPERCPPTLYSLMTRCWSY 600
Query: 1074 DADSRPTFKQL 1084
RP+F +L
Sbjct: 601 SPRDRPSFTEL 611
>UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=1; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 986
Score = 193 bits (471), Expect = 2e-47
Identities = 112/308 (36%), Positives = 172/308 (55%), Gaps = 13/308 (4%)
Query: 819 PNLAKLRIVKEAEL---RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN A KE ++ + ++G G FG+V G G+ ++ VAIK LK
Sbjct: 626 PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGNLKLPGKR-EMFVAIKTLKTGYTEKQ 684
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
++FL EA IM +HPN++ L V ++ +M+IT+ M G L ++R I
Sbjct: 685 RRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDAFLRV---SIHGDQL 741
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL--DINEDEYKAA 992
+ IA GM YL + VHRDLAARN+LV + K++DFGL++ L D ++ Y +A
Sbjct: 742 VGMLRGIASGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSA 801
Query: 993 -GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGL 1051
GGK+PI+W A E IQ+R FT SDVW++G+ +WE++SYG RPY +++ ++V IE
Sbjct: 802 LGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDY 861
Query: 1052 KLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPG--RYLVIPGDKFMRL 1109
+LP P C ++ +M+ CW D ++RP F Q+ + +M R+P + +
Sbjct: 862 RLPPPMDCPSTLHQLMLDCWQKDRNNRPKFSQIVNNLDKMIRNPNTLKAMTPLSSGIPDF 921
Query: 1110 PSYSTQDE 1117
S+ST DE
Sbjct: 922 SSFSTVDE 929
>UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome shotgun
sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 7
SCAF14601, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 761
Score = 193 bits (471), Expect = 2e-47
Identities = 107/307 (34%), Positives = 167/307 (54%), Gaps = 10/307 (3%)
Query: 819 PNLAKLRIVKEAEL---RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN A KE ++ + ++G G FG+V +G G+ VAIK LK
Sbjct: 393 PNEAVREFAKEIDVSFVKIEEVIGAGEFGEVCRGRLKIPGKKENY-VAIKTLKGGYTDKQ 451
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
++FL EA IM +HPN++ L V + +M++T+ M G L ++R + +
Sbjct: 452 RRDFLSEASIMGQFQHPNIIHLEGVITASCPVMILTEFMENGALDSFLRLNDSQFTPIQL 511
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE--YKAA 992
+ IA GM YL E VHRDLAARN+L+ + K++DFGL++ L N + Y ++
Sbjct: 512 VGMLRGIASGMKYLSEMSYVHRDLAARNILINSNLVCKVSDFGLSRFLQENSSDPTYTSS 571
Query: 993 -GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGL 1051
GGK+PI+W A E I R FT SDVW++G+ +WE++S+G RPY ++S ++V IE
Sbjct: 572 LGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDY 631
Query: 1052 KLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPS 1111
+LP P C ++ +M+ CW D +RP F L ++ R+P ++ D+ PS
Sbjct: 632 RLPPPPDCPTHLHQLMLDCWQKDRSARPRFADLVSALDKLIRNPASLKIVAQDRVG--PS 689
Query: 1112 YSTQDEK 1118
Y D++
Sbjct: 690 YPLLDQR 696
>UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -
Caenorhabditis elegans
Length = 533
Score = 193 bits (471), Expect = 2e-47
Identities = 114/258 (44%), Positives = 152/258 (58%), Gaps = 15/258 (5%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG+V+ G W + VAIK +K G + + FL+EA IM +HPNL++L
Sbjct: 268 LGDGNFGEVWYGKW-----RGIVEVAIKTMKP--GTMSPEAFLQEAQIMKQCDHPNLVKL 320
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
AVC + +IT+ M G L+ Y+RT +G +A ++ QIA GM YLEE++LVHR
Sbjct: 321 YAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQALVDMAAQIANGMMYLEERKLVHR 380
Query: 957 DLAARNVLVQTPNS----VKITDFGLAKLLDINEDEYKA-AGGKMPIKWLALECIQHRIF 1011
DLAARNVLV S VK+ DFGLA+ L + ED Y+A G K PIKW A E F
Sbjct: 381 DLAARNVLVGDKISGVPVVKVADFGLARKL-MEEDIYEARTGAKFPIKWTAPEAATCGNF 439
Query: 1012 THKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY-CVMVSC 1070
T KSDVW++G+ ++EI++ G PY + R V E +E G ++P P C IY V++ C
Sbjct: 440 TVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKC 499
Query: 1071 WMLDADSRPTFKQLADTF 1088
W D RPTF L F
Sbjct: 500 WDKTPDRRPTFDTLYHFF 517
>UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Src tyrosine kinase - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 193 bits (471), Expect = 2e-47
Identities = 108/298 (36%), Positives = 171/298 (57%), Gaps = 18/298 (6%)
Query: 806 CEDNEP-LRPTNVKPNLAKLRIVKEAELRRGGML-----GFGAFGKVYKGVWVPEGENVK 859
C +P +RPT+ +P +++ + E+ + ++ G G FG+V+K VW N
Sbjct: 314 CRLGKPCIRPTHPEPVGLSHKLIDKWEIPKSSIILKEKIGQGQFGEVFKAVW-----NKT 368
Query: 860 IPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVC-MTNQMMLITQLMPLGCL 918
VA+K LK ++ + +FL EA M + HPNL+QL AVC T ++T+ M G L
Sbjct: 369 TIVAVKTLKPSSC--DAADFLREAQTMKRLHHPNLIQLYAVCTQTEPFYIVTEYMSKGSL 426
Query: 919 VDYVRTHK-EKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFG 977
++Y+++ + + + + +IA GMAYLE +R +HRDLAARNVLV ++VKI DFG
Sbjct: 427 LNYLQSPEGNALNMQCLIMMAAKIAPGMAYLESRRHIHRDLAARNVLVGEQHAVKIADFG 486
Query: 978 LAKLLDINEDEYKA-AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYE 1036
LA++ I+ EY A AG + PIKW + E + FT KSDVW+FG+ + EI++YG PY
Sbjct: 487 LARM--IHNREYVAHAGARFPIKWTSPEAANYSRFTIKSDVWSFGILLTEIVTYGRSPYP 544
Query: 1037 NISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
+ V ++ G ++ +P C ++Y +M+ CW D + RP+F + + D
Sbjct: 545 GMHNAEVLRQVDAGYRMSKPPGCPPELYDLMLECWAADENKRPSFATIHFRLEQFCED 602
>UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monosiga
ovata|Rep: Protein tyrosine kinase CSK - Monosiga ovata
Length = 468
Score = 193 bits (471), Expect = 2e-47
Identities = 100/261 (38%), Positives = 153/261 (58%), Gaps = 14/261 (5%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+ E+ + +G G FG V++G++ G+ V AIK LK+ G + +FL EA M
Sbjct: 210 ISPREIVKSAQIGSGQFGDVFEGLY--RGQKV----AIKTLKDVQG-DAIDQFLLEADTM 262
Query: 887 ASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAF-LNWCTQIARG 944
+ H NL+QL+ VC +M++++ M GCL+DY+R+ + + A L +C I
Sbjct: 263 TRLRHKNLVQLIGVCTQGSPIMIVSEFMGKGCLLDYLRSRGRAVINLATQLGFCRDICAA 322
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALE 1004
M YLEE++ VHRDLAARN+L+ K+ DFGLAK + + GK+PIKW A E
Sbjct: 323 MEYLEEQKFVHRDLAARNILLSDDGVAKVADFGLAKDSQLGVTDI----GKLPIKWTAPE 378
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
I+ ++ T KSDVW+FGV +WEI ++G PY + + V + + G ++ P C ++Y
Sbjct: 379 AIRLKVSTSKSDVWSFGVVLWEIFAFGRAPYPRMGQKEVVDAVVKGYRMECPDTCPKEVY 438
Query: 1065 -CVMVSCWMLDADSRPTFKQL 1084
+M++CW +D RPTFK L
Sbjct: 439 DKIMMACWEIDPVKRPTFKTL 459
>UniRef50_O45232 Cluster: Putative uncharacterized protein ark-1; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein
ark-1 - Caenorhabditis elegans
Length = 1043
Score = 192 bits (467), Expect = 8e-47
Identities = 106/270 (39%), Positives = 153/270 (56%), Gaps = 7/270 (2%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG V++ W + I VA+K + TS FL+EA IM + H ++++L
Sbjct: 119 LGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRL 178
Query: 898 LAVCM-TNQMMLITQLMPLGCLVDYVRTH--KEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
V + T ++ML+++L G L++ + ++ ++ QIA GM+YLE +RL+
Sbjct: 179 YGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLI 238
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA---AGGKMPIKWLALECIQHRIF 1011
HRDLAARNVLV +P VKI+DFGL++ L I ED Y++ K+PI W A ECI F
Sbjct: 239 HRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKF 298
Query: 1012 THKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLK-LPQPSICTLDIYCVMVSC 1070
T KSDVWA+GVTIWE+ SYG P++ S + EL++ + L +P C DIY ++
Sbjct: 299 TSKSDVWAYGVTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKET 358
Query: 1071 WMLDADSRPTFKQLADTFAEMARDPGRYLV 1100
W RPTF + F E R +V
Sbjct: 359 WTHQVQDRPTFSDIVAKFPERRAQSVRAVV 388
>UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK splice
variant A; n=9; Diptera|Rep: Receptor protein tyrosine
kinase ALK splice variant A - Drosophila melanogaster
(Fruit fly)
Length = 1701
Score = 191 bits (466), Expect = 1e-46
Identities = 143/480 (29%), Positives = 225/480 (46%), Gaps = 42/480 (8%)
Query: 763 TVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMT----MVLTGCEDN-EPLRPTNV 817
++L+I L + + +A L + YN Q+ K K+ KM + LT +N + N
Sbjct: 1107 SILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNF 1166
Query: 818 KPNLA------------KLRIVKEAELRRGGMLGFGAFGKVYKGVWVP-EGENVKIPVAI 864
PN L V L+ LG GAFG+VY ++ +G+ V++ VA+
Sbjct: 1167 NPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAV 1226
Query: 865 KVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVR 923
K L+E ++FL+EA IMA HPN++ L+ VC Q ++ +L+ G L ++R
Sbjct: 1227 KTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLR 1286
Query: 924 THKEK------IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNS---VKIT 974
++ + K L +A+G Y+E KR +HRD+AARN L+ + VKI
Sbjct: 1287 ENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIA 1346
Query: 975 DFGLAKLLDINEDEYKAAGGK--MPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGA 1032
DFG+++ DI +Y GGK +PIKW+ E IFT K+DVW+FG+ +WE+ S G
Sbjct: 1347 DFGMSR--DIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGR 1404
Query: 1033 RPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMA 1092
PY V EL+ G +L P+ C + IY VM CW + RPTF L +
Sbjct: 1405 SPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACT 1464
Query: 1093 RDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDADEYLQPKFKSMTGTV 1152
+D + P + P+ S +D+ +IR G E + +YL P +
Sbjct: 1465 QD-ASIMNAPLPNILG-PTASERDD-TVIR----PPNGEEFCLAVPDYLVPLPPGGSNNP 1517
Query: 1153 TTNSALSAGMETQTSSLKPCTSSSWPNNAGQDGVPDPSTKPEN---WDHEMLRYNNQLNP 1209
+ S E Q + CT + + A P + P + W+ + N+++ P
Sbjct: 1518 SMASGSGYVPELQRQQMSSCTPPAVTSPAAPHPRPVENIAPTSGDCWETSFILPNSKVEP 1577
>UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor
precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CD136
antigen) (CDw136) [Contains: Macrophage- stimulating
protein receptor alpha chain; Macrophage-stimulating
protein receptor beta chain]; n=15; Eutheria|Rep:
Macrophage-stimulating protein receptor precursor (EC
2.7.10.1) (MSP receptor) (p185-Ron) (CD136 antigen)
(CDw136) [Contains: Macrophage- stimulating protein
receptor alpha chain; Macrophage-stimulating protein
receptor beta chain] - Homo sapiens (Human)
Length = 1400
Score = 191 bits (465), Expect = 1e-46
Identities = 102/281 (36%), Positives = 161/281 (57%), Gaps = 15/281 (5%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
++G G FG VY G ++ + +N +I AIK L T + FL E +M + HPN+L
Sbjct: 1087 VIGKGHFGVVYHGEYIDQAQN-RIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 1145
Query: 897 LLAVCMTNQMM--LITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
L+ + + + + ++ M G L+ ++R+ + K +++ Q+ARGM YL E++ V
Sbjct: 1146 LIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFV 1205
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAG----GKMPIKWLALECIQHRI 1010
HRDLAARN ++ +VK+ DFGLA+ DI + EY + ++P+KW+ALE +Q
Sbjct: 1206 HRDLAARNCMLDESFTVKVADFGLAR--DILDREYYSVQQHRHARLPVKWMALESLQTYR 1263
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
FT KSDVW+FGV +WE+L+ GA PY +I ++ + G +LPQP C +Y VM C
Sbjct: 1264 FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQC 1323
Query: 1071 WMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPS 1111
W D RPTF+ L ++ + GD +++LP+
Sbjct: 1324 WEADPAVRPTFRVLVGEVEQIVS------ALLGDHYVQLPA 1358
>UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma
mansoni|Rep: Tyrosine kinase 5 - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 190 bits (463), Expect = 2e-46
Identities = 101/255 (39%), Positives = 151/255 (59%), Gaps = 9/255 (3%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG+V+KG W N VA+K LK+ G T ++FL+EA IM + +HP L++L
Sbjct: 310 LGAGQFGEVWKGTW-----NGTTEVAVKTLKQ--GTMTKEDFLKEARIMRAAQHPKLVRL 362
Query: 898 LAVCMTNQMMLITQLMPLGCLVDYVRTHKEK-IGSKAFLNWCTQIARGMAYLEEKRLVHR 956
AVC + + ++T+LM G L+ Y+R K + ++ QIA GMAYLE++ +HR
Sbjct: 363 YAVCTEDPIYIVTELMCNGSLLQYLRDGPGKNLLINQLVDMMAQIANGMAYLEKEHYIHR 422
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG-KMPIKWLALECIQHRIFTHKS 1015
DLAARN+LV N VK+ DFGLA++++ + Y A K PIKW A E FT KS
Sbjct: 423 DLAARNILVGENNCVKVADFGLARMVEDHYCTYMAQKSTKFPIKWTAPEAALMGRFTIKS 482
Query: 1016 DVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDA 1075
DVW+FG+ I+E+++ G PY +++ + G ++P+P C IY +++ W
Sbjct: 483 DVWSFGIVIYELITLGQVPYPSMNNTETLHQVSTGYRMPRPVNCPQPIYDMLLRIWDSCP 542
Query: 1076 DSRPTFKQLADTFAE 1090
+ RPTF L + F +
Sbjct: 543 EKRPTFSSLFEFFED 557
>UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming protein
ros; n=3; root|Rep: Tyrosine-protein kinase transforming
protein ros - Avian sarcoma virus (strain UR2)
Length = 402
Score = 190 bits (463), Expect = 2e-46
Identities = 132/385 (34%), Positives = 199/385 (51%), Gaps = 38/385 (9%)
Query: 755 PTATARTSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNE--PL 812
P TA + + ++L + SL + +L G+ + Q+ K++K A +VL ED E L
Sbjct: 6 PDITAIVAVIGAVVLGLTSLTIIIL--FGFVWHQRWKSRKPASTGQIVLVK-EDKELAQL 62
Query: 813 R-------------PTNVKPNLAKLRIVK---EAELRRGGMLGFGAFGKVYKGVWVP--- 853
R + P+ A++ + +L +LG GAFG+VY+G +
Sbjct: 63 RGMAETVGLANACYAVSTLPSQAEIESLPAFPRDKLNLHKLLGSGAFGEVYEGTALDILA 122
Query: 854 EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQL 912
+G + VA+K LK EFL+EA++M+ +HP++L+LL VC+ N+ LI +L
Sbjct: 123 DGSG-ESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHILKLLGVCLLNEPQYLILEL 181
Query: 913 MPLGCLVDYVR-THKEKIGSKAF-----LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQ 966
M G L+ Y+R K+K S L+ C I +G YLE+ R +HRDLAARN LV
Sbjct: 182 MEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDICKGCVYLEKMRFIHRDLAARNCLVS 241
Query: 967 TPNS------VKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAF 1020
VKI DFGLA+ + N+ K G +P++W+A E + +FT+ SDVWAF
Sbjct: 242 EKQYGSCSRVVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLIDGVFTNHSDVWAF 301
Query: 1021 GVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPT 1080
GV +WE L+ G +PY +S V + +G +L P+ C DI +M CW D +RPT
Sbjct: 302 GVLVWETLTLGQQPYPGLSNIEVLHHVRSGGRLESPNNCPDDIRDLMTRCWAQDPHNRPT 361
Query: 1081 FKQLADTFAEMARDPGRYLVIPGDK 1105
F + E+ P + GDK
Sbjct: 362 FFYIQHKLQEIRHSPLCFSYFLGDK 386
>UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC
2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein
2).; n=3; Deuterostomia|Rep: Activated CDC42 kinase 1 (EC
2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein
2). - Takifugu rubripes
Length = 1127
Score = 190 bits (462), Expect = 3e-46
Identities = 99/271 (36%), Positives = 157/271 (57%), Gaps = 7/271 (2%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKET--TGANTSKEFLEEA 883
++ E +L LG G+FG V +G W+ V + VA+K LK + + ++F+ E
Sbjct: 132 LIPEKDLTLFEKLGDGSFGVVKRGEWLTPTGKV-LNVAVKCLKTDVLSQPDALEDFICEV 190
Query: 884 YIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVR-THKE-KIGSKAFLNWCTQI 941
M S++H NL++L V +T+ M ++T+L PLG L++ +R H + + + Q+
Sbjct: 191 NAMHSLDHQNLIRLYGVVLTHPMKMVTELAPLGSLLERLRCVHPQGPVLIHTLCQYAVQV 250
Query: 942 ARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKW 1000
+ GMAYLE++R +HRDLAARN+L+ + + +KI DFGL + L N + Y K+P W
Sbjct: 251 SCGMAYLEQRRFIHRDLAARNILLASAHKIKIGDFGLMRALPNNHEHYVMQEHRKVPFAW 310
Query: 1001 LALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE-NGLKLPQPSIC 1059
A E ++ R F+H +D W FGVT+WE+ ++G P+ ++ + I+ G +LP+P C
Sbjct: 311 CAPESLKTRTFSHATDTWMFGVTLWEMFTHGQEPWLGLNGSQILHKIDKEGERLPKPEDC 370
Query: 1060 TLDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
DIY VM+ CW D RPTF L + E
Sbjct: 371 PQDIYNVMLQCWAQKPDDRPTFVALREFLLE 401
>UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor receptor
2; n=11; Clupeocephala|Rep: Plasminogen related growth
factor receptor 2 - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1375
Score = 190 bits (462), Expect = 3e-46
Identities = 104/310 (33%), Positives = 170/310 (54%), Gaps = 17/310 (5%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
++G G FG VY G + + + A+K L T FL E IM +HPN+L
Sbjct: 1070 VIGKGHFGTVYHGYLIDSNKQ-ETHCAVKSLNRITDLKDVDHFLREGLIMKGFDHPNILS 1128
Query: 897 LLAVCMTNQ--MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
LL + + + +++ M G + ++R+ K K + + Q+A+GM YL +K+ V
Sbjct: 1129 LLGIMLPKEGLPLVVLPYMKHGDVRHFIRSEKRNPTVKDLIGFGLQVAKGMEYLAQKKFV 1188
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG----KMPIKWLALECIQHRI 1010
HRDLAARN ++ +VK+ DFG+A+ DI + EY + K+P+KW+A+E +Q +
Sbjct: 1189 HRDLAARNCMLDETYTVKVADFGMAR--DIYDKEYYSIQDHKQVKLPVKWMAIESLQTQK 1246
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
FT KSDVW++G+ +WE+L+ GA PY ++ ++ + G +LPQP C +Y +M+SC
Sbjct: 1247 FTSKSDVWSYGILMWELLTRGASPYPDVDPYDITNYLLKGRRLPQPQFCPNTLYSIMLSC 1306
Query: 1071 WMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLP-SYSTQDEKEMIRNLS-SAM 1128
W + D RP+F LA + L + G+ ++ L +Y D+ +L+ SA
Sbjct: 1307 WDPEPDFRPSFSSLASDVQHI------LLCLQGEHYISLKVNYVNLDQPRPYPSLTGSAD 1360
Query: 1129 EGPESLVDAD 1138
E S +D+D
Sbjct: 1361 EAEASDLDSD 1370
>UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17;
Amniota|Rep: Tyrosine-protein kinase Srms - Homo sapiens
(Human)
Length = 488
Score = 190 bits (462), Expect = 3e-46
Identities = 99/260 (38%), Positives = 156/260 (60%), Gaps = 12/260 (4%)
Query: 830 AELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV 889
+E G LG G FG+V++G+W+ +PVAIKV+K T + +E + +
Sbjct: 228 SEFALGRKLGEGYFGEVWEGLWLGS-----LPVAIKVIKSANMKLT--DLAKEIQTLKGL 280
Query: 890 EHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEK-IGSKAFLNWCTQIARGMAY 947
H L++L AVC + + ++T+LM G L ++ T + + + L + Q+A GM+Y
Sbjct: 281 RHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSY 340
Query: 948 LEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYK-AAGGKMPIKWLALECI 1006
LEE+R+VHRDLAARNVLV + K+ DFGLA+LL +D Y ++ K+P+KW A E
Sbjct: 341 LEEQRVVHRDLAARNVLVDDGLACKVADFGLARLL--KDDIYSPSSSSKIPVKWTAPEAA 398
Query: 1007 QHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCV 1066
+R+F+ KSDVW+FGV + E+ +YG PYE ++ + I G +LP+P+ C ++Y +
Sbjct: 399 NYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVL 458
Query: 1067 MVSCWMLDADSRPTFKQLAD 1086
M+ CW + RP+F L +
Sbjct: 459 MLECWRSSPEERPSFATLRE 478
>UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precursor;
n=81; Tetrapoda|Rep: Hepatocyte growth factor receptor
precursor - Homo sapiens (Human)
Length = 1390
Score = 190 bits (462), Expect = 3e-46
Identities = 96/254 (37%), Positives = 149/254 (58%), Gaps = 9/254 (3%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
++G G FG VY G + + + KI A+K L T +FL E IM HPN+L
Sbjct: 1083 VIGRGHFGCVYHGTLL-DNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 1141
Query: 897 LLAVCMTNQ--MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
LL +C+ ++ +++ M G L +++R K + + Q+A+GM YL K+ V
Sbjct: 1142 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFV 1201
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA----GGKMPIKWLALECIQHRI 1010
HRDLAARN ++ +VK+ DFGLA+ D+ + EY + G K+P+KW+ALE +Q +
Sbjct: 1202 HRDLAARNCMLDEKFTVKVADFGLAR--DMYDKEYYSVHNKTGAKLPVKWMALESLQTQK 1259
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
FT KSDVW+FGV +WE+++ GA PY +++ ++ + G +L QP C +Y VM+ C
Sbjct: 1260 FTTKSDVWSFGVVLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC 1319
Query: 1071 WMLDADSRPTFKQL 1084
W A+ RP+F +L
Sbjct: 1320 WHPKAEMRPSFSEL 1333
>UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin
receptor - Ciona intestinalis (Transparent sea squirt)
Length = 1006
Score = 189 bits (461), Expect = 4e-46
Identities = 99/253 (39%), Positives = 148/253 (58%), Gaps = 11/253 (4%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
++G G FG+V KG + + VAIK LK +FL EA IM +HPN+++
Sbjct: 651 VIGRGEFGEVCKGTFFNKC------VAIKTLKVGYNTQERSDFLGEASIMGQFDHPNVIR 704
Query: 897 LLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
L V ++ +M+IT+ M G L ++R + KI S IA+GM YL VH
Sbjct: 705 LEGVVTKSRPLMIITEFMENGSLDAFLRNQEGKIPSAQLTEMLLSIAQGMEYLSNMGYVH 764
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLD-INEDE---YKAAGGKMPIKWLALECIQHRIF 1011
RDLAARN+LV + K++DFGL+++L+ + ED+ Y GG +PI+W + E I R F
Sbjct: 765 RDLAARNILVNSNLVCKVSDFGLSRVLEQLEEDDVAMYTTRGGMIPIRWTSPEAITMRTF 824
Query: 1012 THKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCW 1071
+ SDVW+FG+ +WE++S+G RPY +S ++V + +++G +LP P C I+ VM+ CW
Sbjct: 825 STSSDVWSFGIVMWEVMSFGERPYWEMSNQDVVQFVDSGYRLPPPCYCPRIIHSVMLECW 884
Query: 1072 MLDADSRPTFKQL 1084
D RP F L
Sbjct: 885 KRDRTQRPNFSHL 897
>UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86;
Coelomata|Rep: Tyrosine-protein kinase Tec - Homo sapiens
(Human)
Length = 631
Score = 189 bits (461), Expect = 4e-46
Identities = 96/267 (35%), Positives = 149/267 (55%), Gaps = 11/267 (4%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+ +EL LG G FG V G W + VAIK ++E GA ++F+EEA +M
Sbjct: 365 INPSELTFMRELGSGLFGVVRLGKW-----RAQYKVAIKAIRE--GAMCEEDFIEEAKVM 417
Query: 887 ASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGM 945
+ HP L+QL VC + + ++T+ M GCL++++R + L+ C + GM
Sbjct: 418 MKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGM 477
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWLALE 1004
YLE +HRDLAARN LV VK++DFG+A+ + +D+Y ++G K P+KW E
Sbjct: 478 EYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARY--VLDDQYTSSSGAKFPVKWCPPE 535
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
+ F+ KSDVW+FGV +WE+ + G P+E + V ++ G +L QP + + +Y
Sbjct: 536 VFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVY 595
Query: 1065 CVMVSCWMLDADSRPTFKQLADTFAEM 1091
VM+ CW + RP+F+ L T E+
Sbjct: 596 EVMLRCWQEKPEGRPSFEDLLRTIDEL 622
>UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor precursor;
n=1; Hydra vulgaris|Rep: Fibroblast growth factor
receptor precursor - Hydra attenuata (Hydra) (Hydra
vulgaris)
Length = 816
Score = 189 bits (461), Expect = 4e-46
Identities = 106/306 (34%), Positives = 176/306 (57%), Gaps = 21/306 (6%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVW--VPEGENVKIPVAIKVLKETTGANTSKEFLEEAY 884
+K +L +LG GAFG+V++ +P V+ VA+K+LKE K+F+ E
Sbjct: 469 IKLEQLETDCLLGEGAFGRVFRATARDLPNHTGVQT-VAVKMLKEDCCEQDLKDFISEIE 527
Query: 885 IMASV-EHPNLLQLLAVC-MTNQMMLITQLMPLGCLVDYVRTHK----------EKIGSK 932
+M S+ +H N+L LLAV ++ ++ + G L +++ ++ +KI
Sbjct: 528 VMKSIGKHINILNLLAVSSQQGKLYIVVEYCRHGNLRSFLKDNRPVMQANSVITKKITLY 587
Query: 933 AFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY--K 990
++C Q+ARGM +L K+ +HRD+AARNVLV +KI DFGLA+ DI+E +Y K
Sbjct: 588 DLTSFCLQVARGMNFLASKKCIHRDIAARNVLVGEGYLMKIADFGLAR--DIHEQDYYRK 645
Query: 991 AAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENG 1050
G++P+KW+A+E + R++T +SD+W+FG+ WEI+++G PY I+ + +L++ G
Sbjct: 646 CTDGRLPVKWMAIEALFDRVYTTQSDIWSFGILAWEIVTFGGSPYPGIALEKLFDLLKQG 705
Query: 1051 LKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPG--RYLVIPGDKFMR 1108
++ +P CT D+Y +M++CW RPTF QL + M D Y+ + + R
Sbjct: 706 YRMERPLNCTDDMYTLMLNCWKEIPSKRPTFSQLIEDLERMLLDASSTEYIDLQPIQPER 765
Query: 1109 LPSYST 1114
S+ST
Sbjct: 766 TESFST 771
>UniRef50_UPI0000E47C0F Cluster: PREDICTED: similar to focal adhesion
kinase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to focal adhesion kinase -
Strongylocentrotus purpuratus
Length = 575
Score = 188 bits (459), Expect = 7e-46
Identities = 84/210 (40%), Positives = 131/210 (62%), Gaps = 1/210 (0%)
Query: 885 IMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARG 944
IM +HP++++L+ VC + ++ +L P G + +++ HK+++ + + + Q++
Sbjct: 28 IMKQFDHPHIIKLIGVCTDPPIWIVMELAPFGEMRMFLQAHKDELTLASLILYAYQLSMA 87
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALE 1004
++YLE K+ VHRD+AARN+LV ++VK+ DFGL++LL + YKA+ GK+PIKW+A E
Sbjct: 88 LSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLH-DHSYYKASKGKLPIKWMAPE 146
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
I R FT SDVW FGV +WEIL YG +P++ + V IENG +LP P+ C +Y
Sbjct: 147 SINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLY 206
Query: 1065 CVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
VM CW + RP FK L E+ +
Sbjct: 207 SVMTLCWSYEPSKRPNFKDLKTRLNEILEE 236
>UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG14396-PA, isoform A - Tribolium castaneum
Length = 1065
Score = 188 bits (459), Expect = 7e-46
Identities = 106/293 (36%), Positives = 164/293 (55%), Gaps = 33/293 (11%)
Query: 838 LGFGAFGKVYKGVWVP-EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
LG G FGKV + + G+ VA+K LK+ + + L E ++ V HPN+++
Sbjct: 749 LGEGEFGKVLRAKALNISGQPGLTTVAVKTLKDDARESELNDLLSEYQLLKEVSHPNVIR 808
Query: 897 LLAVCMT--NQMMLITQLMPLGCLVDYVRTHKE--------------------------K 928
LL VC + LI + G L +Y+R + K
Sbjct: 809 LLGVCTAPGGPIYLIIEFAEHGSLRNYLRRSRHLKSECGRLPSSTVDENDVHYDEPNISK 868
Query: 929 IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE 988
+ K L++ QI +GMAYL E +LVHRDLAARNVL+ KI+DFGL + DI ED+
Sbjct: 869 VTPKEILSFAWQICKGMAYLSEIKLVHRDLAARNVLLAADQICKISDFGLTR--DIYEDD 926
Query: 989 --YKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPEL 1046
+K + G++P+KW+A E + I+T+KSDVW+FG+ +WE+++ GA PY I+ +N+ L
Sbjct: 927 AYFKRSKGRVPVKWMAPESLSDHIYTNKSDVWSFGILVWELVTLGATPYPGIAVQNLFHL 986
Query: 1047 IENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYL 1099
+ G ++ +P C+ +Y +M SCW +D + RPTF++LA + +M D +YL
Sbjct: 987 LRQGYRMERPDNCSPTLYNIMRSCWHIDPEQRPTFQELAALWEKMLSDEVQYL 1039
>UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7223-PA, isoform A - Tribolium castaneum
Length = 861
Score = 187 bits (455), Expect = 2e-45
Identities = 102/275 (37%), Positives = 158/275 (57%), Gaps = 26/275 (9%)
Query: 835 GGMLGFGAFGKVYK----GVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV- 889
G LG GAFGKV K G+ P ++ VA+K+LKE N + + E +M +
Sbjct: 536 GKSLGEGAFGKVVKAEAVGLLKPGASSI---VAVKMLKEGHTDNEMMDLVSEMEMMKMIG 592
Query: 890 EHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTH--------------KEK--IGSK 932
+H N++ LL C + ++ + P G L D++R H KEK + K
Sbjct: 593 KHNNIINLLGCCTQGGPLYVVVEYAPYGNLRDFLRQHRPSSGYEPAIGLEEKEKKTLTQK 652
Query: 933 AFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA 992
+++ Q+ARGM YL +R +HRDLAARNVLV +KI DFGLA+ + N+ K
Sbjct: 653 DLVSFAYQVARGMEYLASRRCIHRDLAARNVLVSDDYFLKIADFGLARDIHCNDYYRKTT 712
Query: 993 GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENI-SARNVPELIENGL 1051
G++P+KW+A E + HR++T +SDVW++G+ +WEI++ G PY ++ S + +L+ NG
Sbjct: 713 DGRLPVKWMAPEALFHRVYTTQSDVWSYGILLWEIMTLGGTPYPSVPSVEKLFQLLRNGH 772
Query: 1052 KLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
++ +P C+L+IY +M CW + RPTF QL +
Sbjct: 773 RMEKPPCCSLEIYMLMRECWSYKPNERPTFSQLVE 807
>UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-protein
kinase; n=38; Euteleostomi|Rep: Megakaryocyte-associated
tyrosine-protein kinase - Homo sapiens (Human)
Length = 507
Score = 187 bits (455), Expect = 2e-45
Identities = 99/273 (36%), Positives = 153/273 (56%), Gaps = 15/273 (5%)
Query: 832 LRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEH 891
L G +G G FG V +G ++ + VA+K +K T++ FL+E +M ++H
Sbjct: 235 LTLGAQIGEGEFGAVLQGEYLGQ------KVAVKNIKCDV---TAQAFLDETAVMTKMQH 285
Query: 892 PNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTH-KEKIGSKAFLNWCTQIARGMAYLEE 950
NL++LL V + + ++ + + G LV+++RT + + + L + +A GM YLE
Sbjct: 286 ENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLES 345
Query: 951 KRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRI 1010
K+LVHRDLAARN+LV K++DFGLAK D ++P+KW A E ++H
Sbjct: 346 KKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDS-----SRLPVKWTAPEALKHGK 400
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
FT KSDVW+FGV +WE+ SYG PY +S + V E +E G ++ P C ++ +M SC
Sbjct: 401 FTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSC 460
Query: 1071 WMLDADSRPTFKQLADTFAEMARDPGRYLVIPG 1103
W + RP F++LA+ A R G + G
Sbjct: 461 WEAEPARRPPFRKLAEKLARELRSAGAPASVSG 493
>UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon
nigroviridis|Rep: Ephrin receptor - Tetraodon
nigroviridis (Green puffer)
Length = 950
Score = 186 bits (454), Expect = 3e-45
Identities = 100/283 (35%), Positives = 161/283 (56%), Gaps = 8/283 (2%)
Query: 819 PNLAKLRIVKEAEL---RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN A KE ++ + ++G G FG+V +G G + VAIK LK
Sbjct: 620 PNDAVHEFAKEIDISCVKIEEVIGAGEFGEVCRGRLKQAGRREMV-VAIKTLKAGYTERQ 678
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHKEKIGSKAF 934
++FL EA IM +HPN+++L V + +++IT+ M G L ++R + +
Sbjct: 679 RRDFLAEASIMGQFDHPNVIRLEGVLTRSCPVLIITEFMENGALDSFLRLNDGRFTMTQL 738
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE--YKAA 992
+ +A GM YL + VHRDLAARN+LV + K++DFGL++ LD + Y ++
Sbjct: 739 VGMLRGVAAGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLDDTSADPTYTSS 798
Query: 993 -GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGL 1051
GGK+PI+W A E I R FT SDVW++G+ +WE++SYG RPY ++S ++V +E
Sbjct: 799 LGGKIPIRWTAPEAIAFRKFTTASDVWSYGIVMWEVVSYGERPYWDMSNQDVMTAVEQDY 858
Query: 1052 KLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
+LP P C + ++ +M+ CWM + + RP F ++ T ++ R+
Sbjct: 859 RLPPPMDCPMVLHQLMLECWMKERNLRPKFSRIVGTLDKLLRN 901
>UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CSK;
n=1; Hydra vulgaris|Rep: Non-receptor protein-tyrosine
kinase CSK - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 467
Score = 186 bits (453), Expect = 4e-45
Identities = 101/250 (40%), Positives = 147/250 (58%), Gaps = 15/250 (6%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
++G G FG VYKGVW K VAIK L++ + T++ L EA +M +++H NL+
Sbjct: 218 LIGKGEFGNVYKGVWA------KKTVAIKKLRDDS--KTAQSLLAEASVMTTLQHKNLVV 269
Query: 897 LLAVCMTNQMMLI-TQLMPLGCLVDYVRTH-KEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
L+A+ +LI T+ G LV+Y+RT + I + + + GM YLEEK ++
Sbjct: 270 LVAISFQGDSILILTEYCEKGVLVEYLRTRGRAVITLEEQKGFAIDVCNGMRYLEEKNII 329
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHK 1014
HRDLAARNVL+ K++DFGLAK D+ E + A GK P+KW A E I+ +IF+ K
Sbjct: 330 HRDLAARNVLLSDELCAKVSDFGLAK--DV---EQELASGKFPVKWTAPEAIELKIFSTK 384
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVW+FG+ +WEI S+G PY + I++ ++ P C +Y +M+ CW D
Sbjct: 385 SDVWSFGILLWEIFSFGRNPYPREPLDELLTKIKSNYRMECPEKCPPFVYQLMLKCWDAD 444
Query: 1075 ADSRPTFKQL 1084
RP+FKQL
Sbjct: 445 PSRRPSFKQL 454
>UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine
protein kinase BTK; n=1; Danio rerio|Rep: PREDICTED:
similar to tyrosine protein kinase BTK - Danio rerio
Length = 596
Score = 186 bits (452), Expect = 5e-45
Identities = 96/256 (37%), Positives = 153/256 (59%), Gaps = 11/256 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG V G W +G + VAIK++KE G+ + +F+EEA +M + H NL+QL
Sbjct: 343 LGNGQFGVVKYGKW--QGRH---DVAIKMVKE--GSMSEDDFIEEAKVMMKLCHGNLVQL 395
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
VC + + ++T+ + GCL++Y++ S A L C ++ GM YLE + +HR
Sbjct: 396 YGVCTKQRPIYIVTEYLANGCLLNYLQEGLLNPTSIALLEMCKDVSEGMKYLEANQFIHR 455
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQHRIFTHKS 1015
DLAARN LV + ++K+TDFGL++ + +DEY ++ G K P++W E + + F+ KS
Sbjct: 456 DLAARNCLVDSNGTIKVTDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKS 513
Query: 1016 DVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDA 1075
D+WAFGV +WEI + G PY+ + + E I G +L +P + +++ +M SCW
Sbjct: 514 DIWAFGVLMWEIYTQGRMPYDRWNNTEIVEKISAGHRLYRPQMANENVFAIMNSCWHERP 573
Query: 1076 DSRPTFKQLADTFAEM 1091
D RPTF++L ++
Sbjct: 574 DERPTFQELVGVIKDL 589
>UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92124 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 510
Score = 186 bits (452), Expect = 5e-45
Identities = 99/247 (40%), Positives = 150/247 (60%), Gaps = 12/247 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG+V+ + N VA+K LK G + + FLEEA +M +++H L++L
Sbjct: 251 LGAGQFGEVWMAFY-----NNSTKVAVKTLKP--GTMSVEAFLEEANLMKTLQHDRLVRL 303
Query: 898 LAVCM-TNQMMLITQLMPLGCLVDYVRTHK-EKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
AV T + +IT+ M G L+D++++ KI +++ QIA GMAY+E+K +H
Sbjct: 304 YAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQLPKLIDFSAQIAEGMAYIEKKNYIH 363
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQHRIFTHK 1014
RDL A NVLV KI DFGLA++++ +D+Y A G K PIKW A E I + FT K
Sbjct: 364 RDLRAANVLVSEMLLCKIADFGLARVIE--DDQYTAREGAKFPIKWTAPEAINYGSFTIK 421
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SD+W+FGV ++EI++YG PY +S V ++ G ++P+P C +++Y +M +CW
Sbjct: 422 SDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYRMPRPENCPVELYEIMTTCWKNK 481
Query: 1075 ADSRPTF 1081
+ RPTF
Sbjct: 482 PEDRPTF 488
>UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome shotgun
sequence; n=8; Clupeocephala|Rep: Chromosome 8 SCAF14552,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 714
Score = 186 bits (452), Expect = 5e-45
Identities = 99/276 (35%), Positives = 153/276 (55%), Gaps = 6/276 (2%)
Query: 825 RIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAY 884
R + L+ ++G FG+V +G + P G ++ VA+K L+ FL EA
Sbjct: 346 REIDPTHLKIEEVIGAAQFGEVSRGRYRPLGRR-EVLVAVKTLRWGASDREKGMFLSEAG 404
Query: 885 IMASVEHPNLLQLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIAR 943
++ +HPN+L+L V T ++T+ M G L ++R ++ + + I
Sbjct: 405 VLGQFDHPNVLKLEGVITRTPPERIVTEFMENGPLDSFLRENEGQFSVLQLVGMLRGIGA 464
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKL---LDINEDEYKAA-GGKMPIK 999
GM YL E+ VHRDLAARNVLV + K++DFGL++L LD N Y A+ G K+P++
Sbjct: 465 GMRYLAERNFVHRDLAARNVLVNSNLVCKVSDFGLSRLMRGLDHNIPTYTASLGSKIPVR 524
Query: 1000 WLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSIC 1059
W A E QHR F+ SDVW+FGV +WE++SYG RPY ++S + V + + + +LP P C
Sbjct: 525 WTAPEAFQHRKFSSASDVWSFGVLMWEVMSYGERPYWDMSNQEVMKAVADQYRLPAPHSC 584
Query: 1060 TLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
++ +M+ CW D RP F+ L + + R P
Sbjct: 585 PPALHSLMLQCWQADRGDRPAFETLLSSLDRLIRHP 620
>UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Ciona
intestinalis|Rep: Ephrin receptor like protein - Ciona
intestinalis (Transparent sea squirt)
Length = 1085
Score = 186 bits (452), Expect = 5e-45
Identities = 95/267 (35%), Positives = 150/267 (56%), Gaps = 7/267 (2%)
Query: 837 MLGFGAFGKVYKGVWV---PEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPN 893
++G G FG+VY+G G+ I VAIK L N +FL EA + +HPN
Sbjct: 721 VIGCGEFGEVYQGSLTLTDTGGKRKVIDVAIKQLHAQCQPNEQIDFLHEAKALERFQHPN 780
Query: 894 LLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTH---KEKIGSKAFLNWCTQIARGMAYLE 949
+++L AV M ++ M++T+LM GCL ++R H K + +A+GMAYL
Sbjct: 781 IVKLEAVVMASRPFMIVTELMVNGCLGKFLRHHRGAKRYFKPTVLVRMLHGVAKGMAYLS 840
Query: 950 EKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHR 1009
+ VHRDLAARNVL+ K+ DFGL + + + GGK+ ++W A E + ++
Sbjct: 841 KMCYVHRDLAARNVLINNELVCKVADFGLIRHIGEKKSTVNTKGGKISLRWTAPEAVAYQ 900
Query: 1010 IFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVS 1069
++ SDVW+FGV WE+++YG +PY +++ + V + I +G +LP P C ++ +M+
Sbjct: 901 AYSQASDVWSFGVFAWEVITYGEKPYWSLTNQQVLQAINDGYRLPAPEDCPSVLHQLMLE 960
Query: 1070 CWMLDADSRPTFKQLADTFAEMARDPG 1096
CW D ++RPTF+Q+ M G
Sbjct: 961 CWHRDKNTRPTFEQVVTRLDAMINQRG 987
>UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to
ENSANGP00000013218; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000013218 - Nasonia
vitripennis
Length = 972
Score = 185 bits (450), Expect = 9e-45
Identities = 103/283 (36%), Positives = 160/283 (56%), Gaps = 22/283 (7%)
Query: 837 MLGFGAFGKVYKGVWVP-EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLL 895
+LG G FG+V + G + VA+K LKE A+ + L E ++ +HPN++
Sbjct: 506 VLGEGEFGRVLRAKAQDIAGWQGQTTVAVKTLKEDASASELADLLSEYQLLKEAQHPNVI 565
Query: 896 QLLAVCMT--NQMMLITQLMPLGCLVDYVRT--HKEKIGSKAF-------------LNWC 938
+LL C T + LI + G L +Y+R H E G + L++
Sbjct: 566 RLLGACTTAGGPIYLIIEFAEFGSLRNYLRRSRHLESEGRPSIDPVVNYTITPRDILSFA 625
Query: 939 TQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE--YKAAGGKM 996
QI++GMAYL + +LVHRDLAARNVL+ KI+DFGL + D+ ED+ K + G++
Sbjct: 626 WQISKGMAYLADIKLVHRDLAARNVLLGAGKVCKISDFGLTR--DVYEDDAYLKRSKGRV 683
Query: 997 PIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQP 1056
P+KW+A E + ++T KSDVW+FGV +WE+++ GA PY + N+ L++ G ++ +P
Sbjct: 684 PVKWMAPESLADHVYTSKSDVWSFGVLLWELVTLGASPYPGVDVHNLYNLLKAGYRMEKP 743
Query: 1057 SICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYL 1099
+ C+ +Y +MVSCW + RP+FK+L + M D YL
Sbjct: 744 ANCSHQLYKLMVSCWHDEPGMRPSFKELTCHWERMLEDAVEYL 786
>UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase receptor - Aedes
aegypti (Yellowfever mosquito)
Length = 2073
Score = 185 bits (450), Expect = 9e-45
Identities = 93/256 (36%), Positives = 153/256 (59%), Gaps = 11/256 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG GAFG+VY+G+ G + VAIK L++ EFL+EA++M++ +H ++L+L
Sbjct: 1818 LGSGAFGEVYEGIVKGVGGEAETRVAIKTLRKGATEQEKAEFLQEAHLMSNFKHKHILKL 1877
Query: 898 LAVCMT-NQMMLITQLMPLGCLVDYVRTHKEKIGSKAFL------NWCTQIARGMAYLEE 950
+ VC+ + + ++ +LM G L+ Y+R+++ G+ + L + C +A G YLEE
Sbjct: 1878 IGVCLDLDSLYIVMELMQGGDLLSYLRSNRPTPGNPSMLTLLDLISMCVDVATGCRYLEE 1937
Query: 951 KRLVHRDLAARNVLVQTPNS----VKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECI 1006
VHRDLA RN LV + + VKI DFGLA+ + N+ K G +P++W++ E +
Sbjct: 1938 MHFVHRDLACRNCLVSSMDPRERVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSPESL 1997
Query: 1007 QHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCV 1066
+FT +SD+WAFGV +WEI++ G +PY + V + +G +L +P C ++Y +
Sbjct: 1998 VDGVFTSQSDIWAFGVLLWEIMTLGQQPYPARNNVEVLHYVRDGGRLTRPQDCPEELYQL 2057
Query: 1067 MVSCWMLDADSRPTFK 1082
M+ CW + RPTF+
Sbjct: 2058 MLKCWSYSPEDRPTFR 2073
>UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5;
Euteleostomi|Rep: Tyrosine-protein kinase BLK - Homo
sapiens (Human)
Length = 505
Score = 185 bits (450), Expect = 9e-45
Identities = 102/261 (39%), Positives = 151/261 (57%), Gaps = 13/261 (4%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+ LR LG G FG+V+ G + N+K VAIK LKE G + + FL EA +M
Sbjct: 236 IPRQSLRLVRKLGSGQFGEVWMGYYK---NNMK--VAIKTLKE--GTMSPEAFLGEANVM 288
Query: 887 ASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHK-EKIGSKAFLNWCTQIARGM 945
+++H L++L AV + ++T+ M GCL+D+++T + ++ ++ QIA GM
Sbjct: 289 KALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALE 1004
AY+E +HRDL A N+LV KI DFGLA+++D EY A G K PIKW A E
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIID---SEYTAQEGAKFPIKWTAPE 405
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
I +FT K+DVW+FGV + E+++YG PY +S V +E G ++P+P C ++Y
Sbjct: 406 AIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELY 465
Query: 1065 -CVMVSCWMLDADSRPTFKQL 1084
V+ CW + RPTF+ L
Sbjct: 466 RGVIAECWRSRPEERPTFEFL 486
>UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:
ENSANGP00000013218 - Anopheles gambiae str. PEST
Length = 861
Score = 184 bits (449), Expect = 1e-44
Identities = 136/429 (31%), Positives = 215/429 (50%), Gaps = 35/429 (8%)
Query: 758 TARTSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNV 817
T +++ +I +V+ + +AV+ ++ Y F +K K + + + G N+
Sbjct: 408 TGPHASIYLIAIVLIPMVVAVMIVL-YCFSRKLTVKNKLLDGSSGANGTIGGMNSISMNL 466
Query: 818 KPNLAKL-RIVKEAELRRGGM-----LGFGAFGKVYKGVWVPEGENVKIP-VAIKVLKET 870
N ++ + E R + LG G FGKV KG E I VA+K+LK
Sbjct: 467 VSNDTEIFNYDSKWEFPRTNLILDATLGEGEFGKVLKGFATDLPEKPGITTVAVKMLK-- 524
Query: 871 TGANTSK--EFLEEAYIMASVEHPNLLQLLAVCMTNQM-MLITQLMPLGCLVDYVRTHK- 926
TGAN+ + L E ++ V HPN+++LL C +LI + G L +Y+R +
Sbjct: 525 TGANSVELLALLSEYQLLQEVNHPNVIRLLGACTKGDSPLLIIEYCQYGSLKNYLRLSRK 584
Query: 927 ------------EKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKIT 974
E I K L++ QI++GMAYL + +LVHRDLAARNVL+ KI+
Sbjct: 585 LEVLNADYENAVEPITVKDILSFAWQISKGMAYLTDIKLVHRDLAARNVLLAEGKVCKIS 644
Query: 975 DFGLAKLLDINEDE--YKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGA 1032
DFGL + D+ ED+ K + ++P+KW+A E + I+T KSDVWAFGV WE+++ GA
Sbjct: 645 DFGLTR--DVYEDDAYLKKSKDRVPVKWMAPESLADHIYTTKSDVWAFGVLCWELITLGA 702
Query: 1033 RPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMA 1092
PY I +N+ L++ G ++ P C+ +IY ++ CW D RP+FK LA F +
Sbjct: 703 SPYPGIPPQNLYNLLKQGYRMECPKNCSEEIYGIVRLCWADDPKQRPSFKHLAGQFELLL 762
Query: 1093 RDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDADEY--LQPKFKSMTG 1150
+YL + + P Y + + ++ + ESL +Y + MTG
Sbjct: 763 GRSAKYLDMEQNSISN-PVYCVNVDGKF--DVFEEQDRLESLWTPPQYETVDTTSAEMTG 819
Query: 1151 TVTTNSALS 1159
T SA++
Sbjct: 820 RYQTPSAMA 828
>UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ROS
precursor; n=20; Eumetazoa|Rep: Proto-oncogene
tyrosine-protein kinase ROS precursor - Homo sapiens
(Human)
Length = 2347
Score = 184 bits (449), Expect = 1e-44
Identities = 104/265 (39%), Positives = 152/265 (57%), Gaps = 16/265 (6%)
Query: 837 MLGFGAFGKVYKGVWVP---EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPN 893
+LG GAFG+VY+G V G +I VA+K LK+ + EFL+EA++M+ HPN
Sbjct: 1950 LLGSGAFGEVYEGTAVDILGVGSG-EIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPN 2008
Query: 894 LLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFL------NWCTQIARGMA 946
+L+ L VC+ N+ +I +LM G L+ Y+R + L + C I++G
Sbjct: 2009 ILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCV 2068
Query: 947 YLEEKRLVHRDLAARNVLVQ-----TPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWL 1001
YLE +HRDLAARN LV +P VKI DFGLA+ + N+ K G +P++W+
Sbjct: 2069 YLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWM 2128
Query: 1002 ALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTL 1061
A E + IFT +SDVW+FG+ IWEIL+ G +PY S +V ++ G +L P C
Sbjct: 2129 APESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPD 2188
Query: 1062 DIYCVMVSCWMLDADSRPTFKQLAD 1086
D++ +M CW + D RPTF ++ D
Sbjct: 2189 DLWNLMTQCWAQEPDQRPTFHRIQD 2213
>UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2;
Caenorhabditis|Rep: C-terminal src kinase protein 1 -
Caenorhabditis elegans
Length = 539
Score = 184 bits (448), Expect = 2e-44
Identities = 101/261 (38%), Positives = 148/261 (56%), Gaps = 11/261 (4%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYI 885
++ ++ G +G G FG V G + +N K VA+KV K G L+EA
Sbjct: 277 VISSNDIDVGDTIGHGEFGDVRLGTY----KNRK--VALKVSKRH-GNGMLDSLLDEAKF 329
Query: 886 MASVEHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTH-KEKIGSKAFLNWCTQIAR 943
M + HPNL+ L+ V + + + +IT+ M G L+D +R+ + + + + + I +
Sbjct: 330 MVGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMFAMDICQ 389
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLAL 1003
GM YLE K++VHRDLAARNVL+ K++DFGLAK N + +A GK PIKW A
Sbjct: 390 GMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAK--KANSQSHDSASGKFPIKWTAP 447
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDI 1063
E ++H FT KSDVW+FG+ +WEI S+G PY I ++V IE G ++ P C +I
Sbjct: 448 EALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEI 507
Query: 1064 YCVMVSCWMLDADSRPTFKQL 1084
+ VM W L A RP+F Q+
Sbjct: 508 FKVMNETWALSAQDRPSFGQV 528
>UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP09923p -
Drosophila melanogaster (Fruit fly)
Length = 847
Score = 184 bits (448), Expect = 2e-44
Identities = 108/271 (39%), Positives = 163/271 (60%), Gaps = 16/271 (5%)
Query: 816 NVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
N K + K ++ EAEL+ +G G FG V G+ N K VA+K+LK+ GA
Sbjct: 579 NSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGIL----RNEK--VAVKMLKDE-GA-- 629
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTH-KEKIGSKA 933
++FL EA +M ++EH NL++ + + T++ + L+T+ M G LVDY+R+ ++ I K
Sbjct: 630 VQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKD 689
Query: 934 FLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAG 993
+ + A GM YLE K++VHRDLAARNVL+ K++DFGLA+ E+ Y
Sbjct: 690 QIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYNLDV 744
Query: 994 GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKL 1053
GK+PIKW A E +++ F++KSD+W+FG+ +WEI S+G PY I +V + +E G K+
Sbjct: 745 GKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKM 804
Query: 1054 PQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
P C +IY +M W L+ RPTF +L
Sbjct: 805 EAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 835
>UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 337
Score = 184 bits (448), Expect = 2e-44
Identities = 107/288 (37%), Positives = 166/288 (57%), Gaps = 24/288 (8%)
Query: 835 GGMLGFGAFGKVYKG--VWVPEG-ENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-E 890
G ++G GAFGKV K V +P G EN + VA+K L + FL E +M + +
Sbjct: 21 GEVVGSGAFGKVTKATIVGLPGGPENKETVVAVKKLNAMATMEDRRNFLSEIEMMKQLGK 80
Query: 891 HPNLLQLLAVCMTN--QMMLITQLMPLGCLVDYVRTHKEKIGSKA--------------- 933
H N++ +L C+T+ Q+ LIT+ P G L +Y+R ++K+ ++
Sbjct: 81 HLNIVSILG-CVTHAGQLCLITEYCPYGDLRNYLRAIRDKVSTRDSLAGRAPGRELTQND 139
Query: 934 FLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAG 993
L++ QIA GM YL +K VHRDLAARN+L+ N VKI+DFGL + + + + +K
Sbjct: 140 LLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVYESSEYHKMHN 199
Query: 994 -GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLK 1052
GK+P+KW+A E I + T KSDVWAFGV +WEI++ G PY S + + ++NG +
Sbjct: 200 TGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKEFYKKLKNGYR 259
Query: 1053 LPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAE-MARDPGRYL 1099
+ +P +C+ ++Y +M SCW + RPTF +L + + M R+ Y+
Sbjct: 260 MEKPDMCSPELYAMMRSCWASSPEDRPTFTKLRNQLEQLMDREDELYI 307
>UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12;
Eumetazoa|Rep: Tyrosine-protein kinase Fps85D -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 184 bits (447), Expect = 2e-44
Identities = 89/250 (35%), Positives = 148/250 (59%), Gaps = 11/250 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
+G G FG VYK + ++ K+ VA+K + T ++FL+E I+ +HPN+++L
Sbjct: 1069 IGRGNFGDVYKA----KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKL 1124
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
+ +C+ Q +M++ +L+ G L+ Y+R + + ++ + C A GM YLE K +HR
Sbjct: 1125 IGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHR 1184
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG--KMPIKWLALECIQHRIFTHK 1014
DLAARN LV +SVKI+DFG+++ E+EY + G ++P+KW A E + +T
Sbjct: 1185 DLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSL 1240
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
DVW++G+ +WEI S G PY ++ E I+ G ++P P ++Y +M+ CW D
Sbjct: 1241 CDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAAD 1300
Query: 1075 ADSRPTFKQL 1084
A+SRP F ++
Sbjct: 1301 AESRPHFDEI 1310
>UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1
precursor; n=2; Dugesia japonica|Rep: Fibroblast growth
factor receptor 1 precursor - Dugesia japonica
(Planarian)
Length = 854
Score = 184 bits (447), Expect = 2e-44
Identities = 99/267 (37%), Positives = 153/267 (57%), Gaps = 15/267 (5%)
Query: 838 LGFGAFGKVYKGVWVPEGENVK-IPVAIKVLKETTGANTSKEFLEEAYIMASV-EHPNLL 895
LG GAFG VY+G+ G I VA+K++++ + +F++E IM + HPN++
Sbjct: 557 LGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRDDFSDSNVHDFVKEMEIMKHIGRHPNVI 616
Query: 896 QLLAVC-MTNQMMLITQLMPLGCLVDYVRTHKEK-------IGSKAFLNWCT---QIARG 944
QLL +C + +I +L P G L D+VR +K IG+ CT QIARG
Sbjct: 617 QLLGLCTQKGPLRVIVELAPYGNLRDFVRAKNKKYSKSKKIIGNFTSSILCTYSLQIARG 676
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALE 1004
M YL + +VHRDL+ARN+LV +KI DFGL +++D K G +P+KW+A E
Sbjct: 677 MTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTRIVDYYYR--KKTDGILPVKWMAPE 734
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
+ + +T KSDVW++G+ +WEI + G PY I V +LI G + P+P + +IY
Sbjct: 735 ALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEKVVDLIRKGFQNPKPELANFEIY 794
Query: 1065 CVMVSCWMLDADSRPTFKQLADTFAEM 1091
+M CW L +++RP F ++ + ++
Sbjct: 795 RLMQHCWSLSSENRPNFFEIVEILIDI 821
>UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9;
Clupeocephala|Rep: C-Met receptor tyrosine kinase - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1382
Score = 183 bits (446), Expect = 3e-44
Identities = 95/255 (37%), Positives = 149/255 (58%), Gaps = 11/255 (4%)
Query: 837 MLGFGAFGKVYKGVWV-PEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLL 895
++G G FG V+ G + P+G+ K AIK L T +FL+E I+ HPN+L
Sbjct: 1084 IIGRGHFGCVFHGTLLEPDGQ--KQHCAIKSLNRITDIEEVSQFLKEGIIVKDFSHPNVL 1141
Query: 896 QLLAVCMTNQ--MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRL 953
LL +C+ ++ +++ M G L +++R K + + Q+A+GM YL K+
Sbjct: 1142 SLLGICLPSEGSPLVVLPYMKHGDLRNFIRDESHNPTVKDLMGFGLQVAKGMEYLASKKF 1201
Query: 954 VHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA----GGKMPIKWLALECIQHR 1009
VHRDLAARN ++ +VK+ D GLA+ D+ + EY + G K+P+KW+ALE +Q
Sbjct: 1202 VHRDLAARNCMLDESYTVKVADVGLAR--DVYDKEYYSVHNKHGVKLPVKWMALESLQTH 1259
Query: 1010 IFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVS 1069
FT KSDVW+FGV +WE+++ GA PY ++++ ++ + G +L QP C +Y VM+
Sbjct: 1260 KFTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYNVMIE 1319
Query: 1070 CWMLDADSRPTFKQL 1084
CW + RPTF +L
Sbjct: 1320 CWHPKPERRPTFLEL 1334
>UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21;
Deuterostomia|Rep: Tyrosine-protein kinase CSK - Homo
sapiens (Human)
Length = 450
Score = 183 bits (446), Expect = 3e-44
Identities = 102/259 (39%), Positives = 145/259 (55%), Gaps = 17/259 (6%)
Query: 831 ELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVE 890
EL+ +G G FG V G + G V A+K +K T++ FL EA +M +
Sbjct: 194 ELKLLQTIGKGEFGDVMLGDY--RGNKV----AVKCIKNDA---TAQAFLAEASVMTQLR 244
Query: 891 HPNLLQLLAVCMTNQ--MMLITQLMPLGCLVDYVRTH-KEKIGSKAFLNWCTQIARGMAY 947
H NL+QLL V + + + ++T+ M G LVDY+R+ + +G L + + M Y
Sbjct: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304
Query: 948 LEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQ 1007
LE VHRDLAARNVLV N K++DFGL K +D GK+P+KW A E ++
Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT-----GKLPVKWTAPEALR 359
Query: 1008 HRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVM 1067
+ F+ KSDVW+FG+ +WEI S+G PY I ++V +E G K+ P C +Y VM
Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419
Query: 1068 VSCWMLDADSRPTFKQLAD 1086
+CW LDA RP+F QL +
Sbjct: 420 KNCWHLDAAMRPSFLQLRE 438
>UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora|Rep:
CG14396-PD, isoform D - Drosophila melanogaster (Fruit
fly)
Length = 1237
Score = 182 bits (444), Expect = 5e-44
Identities = 103/295 (34%), Positives = 167/295 (56%), Gaps = 20/295 (6%)
Query: 822 AKLRIVKEAELRRGGMLGFGAFGKVYKGVWVP-EGENVKIPVAIKVLKETTGANTSKEFL 880
AK +E +L+ +LG G FG+V KG G VA+K+LK+ + + L
Sbjct: 764 AKWEFPRE-KLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALL 822
Query: 881 EEAYIMASVEHPNLLQLLAVCMTNQM-MLITQLMPLGCLVDYVRTHK------------- 926
E ++ V HPN+++LL C +++ +LI + G L Y+R +
Sbjct: 823 SEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGV 882
Query: 927 EKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINE 986
E + K L + QI +GMAYL E +LVHRDLAARNVL+ KI+DFGL + D+ E
Sbjct: 883 EPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTR--DVYE 940
Query: 987 DE--YKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVP 1044
D+ K + ++P+KW+A E + ++T KSDVW+FGV WE+++ GA PY I+ +N+
Sbjct: 941 DDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLW 1000
Query: 1045 ELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYL 1099
L++ G ++ +P C+ +Y ++ +CW + + RP+FK LA F ++ + +Y+
Sbjct: 1001 SLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYI 1055
>UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000020257 - Anopheles gambiae
str. PEST
Length = 1192
Score = 182 bits (444), Expect = 5e-44
Identities = 89/250 (35%), Positives = 146/250 (58%), Gaps = 10/250 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
+G G FG VYK + +N VA+K + T ++FL+E I+ +HPN+++L
Sbjct: 937 IGRGNFGDVYKAK-LKSSKNTL--VAVKTCRMTLPEEQKRKFLQEGRILKQYDHPNIVKL 993
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
+ +C+ Q +M++ +L+ G L+ ++R + +G + + C A GM YLE K +HR
Sbjct: 994 IGICVQKQPIMIVMELVAGGSLLMFLRKNASTLGQRQMMGMCRDAAAGMRYLESKNCIHR 1053
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG--KMPIKWLALECIQHRIFTHK 1014
DLAARN L+ + N VKI+DFG+++ E+EY +GG ++PIKW A E + +T
Sbjct: 1054 DLAARNCLIGSENIVKISDFGMSR----EEEEYIVSGGMKQIPIKWTAPEALNFGKYTSL 1109
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
DVW++G+ +WEI S G PY +S E I+ G ++P P ++Y +M+ CW +
Sbjct: 1110 CDVWSYGILVWEIFSRGDTPYSGMSNSMARERIDEGYRMPAPEGAPPEMYRLMLKCWSYE 1169
Query: 1075 ADSRPTFKQL 1084
+SRP F ++
Sbjct: 1170 PESRPHFDEI 1179
>UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles gambiae str. PEST|Rep: Tyrosine-protein kinase
receptor - Anopheles gambiae str. PEST
Length = 2075
Score = 182 bits (443), Expect = 6e-44
Identities = 95/257 (36%), Positives = 150/257 (58%), Gaps = 11/257 (4%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
+LG GAFG+VY+GV + VAIK LK+ + +EFL+EA +M++ +H ++ +
Sbjct: 1810 LLGSGAFGEVYEGVVKGVDGEAETRVAIKTLKKGAKLHEKQEFLQEAQLMSNFKHKHITR 1869
Query: 897 LLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKA------FLNWCTQIARGMAYLE 949
LL VC+ + +++I +LM G L+ Y+R + G A ++ C +A G YLE
Sbjct: 1870 LLGVCLEADALLIIMELMQGGDLLSYLRRSRSLPGQAARLTMLDLISMCQDVASGCRYLE 1929
Query: 950 EKRLVHRDLAARNVLVQTPNS----VKITDFGLAKLLDINEDEYKAAGGKMPIKWLALEC 1005
E VHRDLA RN LV + + VKI DFGLA+ + N+ K G +P++W++ E
Sbjct: 1930 EMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSPES 1989
Query: 1006 IQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYC 1065
+ +FT +SD+WAFGV +WEI++ G +PY+ + V + G L +P +C ++Y
Sbjct: 1990 LVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNVEVLNHVREGGHLDRPKVCPNEMYE 2049
Query: 1066 VMVSCWMLDADSRPTFK 1082
+M CW + RPTF+
Sbjct: 2050 LMKYCWKFSPEERPTFR 2066
>UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1;
Eptatretus burgeri|Rep: TEC family protein tyrosine
kinase - Eptatretus burgeri (Inshore hagfish)
Length = 636
Score = 182 bits (442), Expect = 8e-44
Identities = 100/287 (34%), Positives = 153/287 (53%), Gaps = 15/287 (5%)
Query: 811 PLRPTNVKPNLAKLRIVK----EAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKV 866
P+RP P+ A L K EL LG GA G V G+W V+ +AI++
Sbjct: 353 PVRPGEELPSTAGLSYGKWELDALELTSLRELGRGALGVVQLGMW----RGVR-HIAIRM 407
Query: 867 LKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTH 925
L E G +F E +M + HPNL+QL V + + ++ + + LGCL +++
Sbjct: 408 LHE--GVLAEDDFFHEVKLMMQLSHPNLVQLYGVVTRYRPLRIVMEYLALGCLRTFLQAR 465
Query: 926 KEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDIN 985
K+GS L C+ + + M YLE +HRDLAAR+ LV S+K++DFG+A+ +
Sbjct: 466 PGKLGSAWLLEACSDVCKAMVYLESNSFLHRDLAARHCLVGEDFSIKVSDFGMARY--VL 523
Query: 986 EDEYKAA-GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVP 1044
+D+Y + G + P+KW E F+ KSDVW+FGV +WE+ S G PY+ S V
Sbjct: 524 DDQYTCSQGARFPVKWSPPEVFDRGRFSSKSDVWSFGVVMWEVFSEGTLPYDGWSNGEVV 583
Query: 1045 ELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
E + G +LPQP++ +Y +M CW D + RP F +L + ++
Sbjct: 584 ESVHAGYQLPQPTLAPTPVYTIMCDCWQPDPEKRPYFMKLLELITDL 630
>UniRef50_Q25410 Cluster: Putative molluscan insulin-related
peptide(s) receptor precursor (EC 2.7.10.1) [Contains:
Putative molluscan insulin-related peptide(s) receptor
alpha chain; Putative molluscan insulin-related
peptide(s) receptor beta chain]; n=2; Coelomata|Rep:
Putative molluscan insulin-related peptide(s) receptor
precursor (EC 2.7.10.1) [Contains: Putative molluscan
insulin-related peptide(s) receptor alpha chain; Putative
molluscan insulin-related peptide(s) receptor beta chain]
- Lymnaea stagnalis (Great pond snail)
Length = 1607
Score = 182 bits (442), Expect = 8e-44
Identities = 111/346 (32%), Positives = 189/346 (54%), Gaps = 24/346 (6%)
Query: 755 PTATARTSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRP 814
P ++T+L++ +V+A + +++I K K + + + + +E L
Sbjct: 967 PPDPESSNTLLIVAIVLAFFGVLTVSLIVACVYYKQKIRSDDMTVISRNMNYVPSEILYI 1026
Query: 815 TNV-KPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGV--WVPEGENVKIPVAIKVLKETT 871
++ + + K++++KE LG G+FG VY+GV + + N +IPVA+K + +
Sbjct: 1027 SDEWEVDRDKIKLIKE--------LGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRA 1078
Query: 872 GANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIG 930
+ +EFL+EA M ++++LL V T Q ++I +LM LG L +Y+R H+
Sbjct: 1079 SFSDRREFLKEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYLRGHRPDED 1138
Query: 931 SKA--------FLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL 982
L +IA GMAYL +K+ VHRDLAARN +V +VKI DFG+ +
Sbjct: 1139 HPGVMPPHLLDILQMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTVKIGDFGMTR-- 1196
Query: 983 DINEDEYKAAGGK--MPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISA 1040
DI E +Y GGK +P++W+A E ++ +FT SDVW++GV +WE+++ A+PY+ +S
Sbjct: 1197 DIYETDYYRKGGKGMLPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLSN 1256
Query: 1041 RNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
V + I +G + P C ++ +M CW + RPTFK + +
Sbjct: 1257 EEVVKFISDGYIMELPENCPNEMAYLMQHCWAKKPNQRPTFKAIIE 1302
Score = 113 bits (272), Expect = 3e-23
Identities = 121/479 (25%), Positives = 206/479 (43%), Gaps = 76/479 (15%)
Query: 20 NCTYVDGNLELTWLENESMDLSFLKY--IREVTGYVLISHV---KVHKIVLPQLQIIRGR 74
NCT ++G+L ++ E +++D L + +RE+T Y+L+ V + + P L IIRGR
Sbjct: 82 NCTVIEGSLRISLFELKALDFRHLSFPDLREITDYLLMYRVYGLETLSKLFPNLAIIRGR 141
Query: 75 TLFKLNVREEEFALLV-TMSTAFTLELPALRDVLQGSVGIYSNFNLCHVKTINWDEINQD 133
LF +A+++ M L L LR + +G V + NF LC+++TINW +I
Sbjct: 142 ELFN------SYAIVMYEMRDLQDLGLVNLRTISRGGVRLTKNFKLCYIETINWTQIGVS 195
Query: 134 LTQVTFTFIILPLGKGNARVVTQPAR-WAAGESIENCQKFSKTICSPQCAQGRCFGPNPR 192
+ + + Q R W + +CQK C QC + N
Sbjct: 196 DPEARRFINNKEQCPNSCKDECQSKRCW----TYSDCQKGLN--C--QCKENTYCMEN-G 246
Query: 193 DCCNTFCAGGCTGPL-PTQCLACRNFYDEGTCSQECPSMQIYNPTTYSWEPNPNGKYAYG 251
CC+ +C GGC P+ P +C +C+ TC +CP P TY + N +
Sbjct: 247 SCCHDYCLGGCKVPMNPDECFSCKEVQFNNTCRPQCP------PGTYKF---LNRRCLTD 297
Query: 252 ATCVR-------NCPEHLLKDNG---ACVRSCPPNKTAVN-------GECIPCVGTCPKT 294
C+ N P+ L + G C+ +CP N + + +C+ C CPK
Sbjct: 298 KECLALTNDPDGNTPKLLDGEKGEPSLCLYTCPQNYSVGDSKDNKNLSQCVKCRQLCPKE 357
Query: 295 CRAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALEVFS 354
C + + + K+C+ I G ++I M+ + Q + S G
Sbjct: 358 CHGLEINNIQDAHKLKECSKISGPLKIQIMSGSNVAQ-ELEKSLG--------------- 401
Query: 355 TVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGR----QVVENLFASLYIVKTXXXX---- 406
+REVT ++++ + +L +F+NL++IG + + E SL+++
Sbjct: 402 NIREVTETIHIKRSYA-LVTLHFFKNLQIIGSKVPSSETQEGQSFSLFLMDNTNLQELFP 460
Query: 407 XXXXXXXXVNSGAIAIMENRNLC-YADKIAWNKLVKSKDHKQIIQ-KNGDPRQCEKNNL 463
+ +G I + +N LC + K + L S+ I NG R CEK++L
Sbjct: 461 EEQMKKMKILNGGIYVHDNGQLCPHTIKEFLSHLNLSEAQSSISSISNGHQRPCEKHDL 519
Score = 68.1 bits (159), Expect = 2e-09
Identities = 52/201 (25%), Positives = 80/201 (39%), Gaps = 21/201 (10%)
Query: 353 FSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXXXXXXXXX 412
F +RE+T YL + + T F NL +I GR++ + +Y ++
Sbjct: 107 FPDLREITDYLLMYRVYGLETLSKLFPNLAIIRGRELFNSYAIVMYEMRDLQDLGLVNLR 166
Query: 413 XXVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNLVCDPQCSAD 472
++ G + + +N LCY + I W ++ S + N + QC + C +C +
Sbjct: 167 T-ISRGGVRLTKNFKLCYIETINWTQIGVSDPEARRFINNKE--QCPNS---CKDECQSK 220
Query: 473 GCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCTGASRAN-C 531
CW CQ NC Y ++ SC CH CL GC + C
Sbjct: 221 RCWTYS-----DCQKGL-------NCQCKENTYCMENGSC--CHDYCLGGCKVPMNPDEC 266
Query: 532 TSCKHVRDGPYCVAQCPESRY 552
SCK V+ C QCP Y
Sbjct: 267 FSCKEVQFNNTCRPQCPPGTY 287
>UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX;
n=36; Euteleostomi|Rep: Cytoplasmic tyrosine-protein
kinase BMX - Homo sapiens (Human)
Length = 675
Score = 182 bits (442), Expect = 8e-44
Identities = 95/260 (36%), Positives = 148/260 (56%), Gaps = 11/260 (4%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+K E+ LG G FG V G W +G+ VA+K++KE G+ + EF +EA M
Sbjct: 412 LKREEITLLKELGSGQFGVVQLGKW--KGQ---YDVAVKMIKE--GSMSEDEFFQEAQTM 464
Query: 887 ASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGM 945
+ HP L++ VC + ++T+ + GCL++Y+R+H + + L C + GM
Sbjct: 465 MKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGM 524
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWLALE 1004
A+LE + +HRDLAARN LV VK++DFG+ + + +D+Y + G K P+KW A E
Sbjct: 525 AFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRY--VLDDQYVSSVGTKFPVKWSAPE 582
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
+ ++ KSDVWAFG+ +WE+ S G +PY+ V + G +L +P + + IY
Sbjct: 583 VFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIY 642
Query: 1065 CVMVSCWMLDADSRPTFKQL 1084
+M SCW + RPTF+QL
Sbjct: 643 QIMYSCWHELPEKRPTFQQL 662
>UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:153964
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 511
Score = 181 bits (441), Expect = 1e-43
Identities = 103/278 (37%), Positives = 155/278 (55%), Gaps = 11/278 (3%)
Query: 812 LRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETT 871
++P NV P + + E + LG G F VY G W + VAIK+LK
Sbjct: 228 IKPENVPPPSTDEWELPKEEFQLENQLGSGHFADVYSGKWKNHSK-----VAIKILKNND 282
Query: 872 GANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEK-I 929
A +EF E IM + H +L+ L AVC ++ +IT+L+ G L+ ++R + + +
Sbjct: 283 -ALVLREFQLEVQIMKRLRHKHLISLFAVCTSSSPFYIITELIEKGDLLHFLRNPEGRSL 341
Query: 930 GSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY 989
++ ++ Q+A GMAYLE +HRDLAARNVLV KI DFGLA++ I E Y
Sbjct: 342 QMESLIDMAAQVADGMAYLEANNSIHRDLAARNVLVGDGYVCKIADFGLARI--IKEPVY 399
Query: 990 KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELI-E 1048
+ K+P KW A E I H ++ KSDVW+FG+ ++EI+++G PY ++ V +LI +
Sbjct: 400 LSDDKKIPYKWTAPEAIGHGTYSSKSDVWSFGILLYEIVTHGGIPYPGVNTGEVYDLITK 459
Query: 1049 NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
++P P C IY +M +CW +++ RP FK L D
Sbjct: 460 ENYRMPSPPKCPQAIYNIMRACWRIESVDRPNFKVLKD 497
>UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 295
Score = 181 bits (441), Expect = 1e-43
Identities = 97/278 (34%), Positives = 160/278 (57%), Gaps = 21/278 (7%)
Query: 837 MLGFGAFGKVYKG-VWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVE-HPNL 894
+LG GAFG V K +G +PVA+K++KE ++ + E ++ ++ HPN+
Sbjct: 14 VLGSGAFGVVMKADAQGIKGCVGSLPVAVKIVKENDSDTARRDLMAELDLLKLIDPHPNV 73
Query: 895 LQLLAVCMTNQ-MMLITQLMPLGCLVDYVR---------------THKEKIGSKAFLNWC 938
+ LL C +M+I + G L Y+R ++K+ +K L++
Sbjct: 74 IGLLGCCTRGDPLMVIVEFCQYGDLQSYLRHCRGIEDKYYEQIYMVPEKKLTAKDLLSFG 133
Query: 939 TQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY--KAAGGKM 996
Q ARGMA+L ++VHRDLAARN+L+ + K++DFG A+ + + ED Y K GG+
Sbjct: 134 IQAARGMAHLASMKVVHRDLAARNILIDEKSVCKVSDFGFARDIYV-EDHYTRKTQGGRF 192
Query: 997 PIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQP 1056
PIKW+A+E + + T KSDVW++GV +WEI++ GA PY ++++ V +++G ++ +P
Sbjct: 193 PIKWMAIESLLDGVSTTKSDVWSYGVLLWEIVTLGASPYPGMNSQEVINFLQDGYRMDKP 252
Query: 1057 SICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
C ++Y VM+ CW L A RPTF +++ +M D
Sbjct: 253 KHCLDELYAVMLDCWQLSAQRRPTFVEISRLLNKMLSD 290
>UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77;
Eutheria|Rep: Proto-oncogene c-fes variant 4 - Homo
sapiens (Human)
Length = 752
Score = 181 bits (440), Expect = 1e-43
Identities = 92/262 (35%), Positives = 150/262 (57%), Gaps = 9/262 (3%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYI 885
++ +L G +G G FG+V+ G +N VA+K +ET + +FL+EA I
Sbjct: 485 VLNHEDLVLGEQIGRGNFGEVFSGRL--RADNTL--VAVKSCRETLPPDLKAKFLQEARI 540
Query: 886 MASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARG 944
+ HPN+++L+ VC Q + ++ +L+ G + ++RT ++ K L A G
Sbjct: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 600
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG--KMPIKWLA 1002
M YLE K +HRDLAARN LV N +KI+DFG+++ + + Y A+GG ++P+KW A
Sbjct: 601 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSR--EEADGVYAASGGSRQVPVKWTA 658
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLD 1062
E + + ++ +SDVW+FG+ +WE S GA PY N+S + E +E G +LP P +C
Sbjct: 659 PEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDA 718
Query: 1063 IYCVMVSCWMLDADSRPTFKQL 1084
++ +M CW + RP+F +
Sbjct: 719 VFRLMEQCWAYEPGQRPSFSTI 740
>UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC
2.7.10.2).; n=1; Xenopus tropicalis|Rep: Tyrosine-protein
kinase Tec (EC 2.7.10.2). - Xenopus tropicalis
Length = 647
Score = 180 bits (439), Expect = 2e-43
Identities = 92/247 (37%), Positives = 142/247 (57%), Gaps = 11/247 (4%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+ +EL LG G FG V G W + VAIK ++E GA + ++F+EEA +M
Sbjct: 407 INPSELTFMKELGSGLFGVVRLGKW-----RAQYKVAIKAIRE--GAMSEEDFIEEAKVM 459
Query: 887 ASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGM 945
+ H L+QL VC + + ++T+ M GCL++Y+R + L+ C + M
Sbjct: 460 MKLTHLKLVQLYGVCTQQRPIYIVTEFMEHGCLLNYLRQRHGQFSPDILLSMCQDVCEAM 519
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALE 1004
+YLE+ +HRDLAARN LV VK++DFG+ + + +D+Y ++ G K P+KW E
Sbjct: 520 SYLEQNNFIHRDLAARNCLVNDAGVVKVSDFGMTRY--VLDDQYTSSCGAKFPVKWSPPE 577
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
+ F+ KSDVW+FGV +WE+ + G P+E+ S V E++ G +L +P + T IY
Sbjct: 578 VFNYSRFSSKSDVWSFGVLMWEVFTEGKMPFESYSNVEVVEMVTRGERLYRPKLATKIIY 637
Query: 1065 CVMVSCW 1071
VMV+CW
Sbjct: 638 SVMVACW 644
>UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein; n=3;
Danio rerio|Rep: PREDICTED: hypothetical protein - Danio
rerio
Length = 510
Score = 179 bits (436), Expect = 4e-43
Identities = 96/249 (38%), Positives = 145/249 (58%), Gaps = 11/249 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G F VY+G W +G + VAIK+LK + +EF+ E I+ + H +L+ L
Sbjct: 249 LGKGFFADVYRGKW--KG---MVNVAIKILKNDS--INHREFMLETQILKKLRHKHLIAL 301
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHK-EKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
AVC ++ +IT+LM G L+ ++ + + + ++ +Q+A GMAYLEE+ +H
Sbjct: 302 FAVCTSSSPFYIITELMEKGDLLSLLKGKEGQDLNAQMLTEMASQVADGMAYLEEQNSIH 361
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKS 1015
RDLAARNVLV K+ D GLA++ + E Y + ++P KW A E I H F++KS
Sbjct: 362 RDLAARNVLVGANYICKVADLGLARI--VKESVYSSEDAQIPYKWSAPEAISHGRFSNKS 419
Query: 1016 DVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDA 1075
DVW+FGV ++E+ +YG PY S V +I +G ++P P C IY +M+ CW A
Sbjct: 420 DVWSFGVLLYEMFTYGGVPYPAFSNIEVYNMITSGYRMPAPPNCPSHIYDIMLMCWRYSA 479
Query: 1076 DSRPTFKQL 1084
+ RP F +L
Sbjct: 480 EERPDFSEL 488
>UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 557
Score = 179 bits (436), Expect = 4e-43
Identities = 92/278 (33%), Positives = 151/278 (54%), Gaps = 15/278 (5%)
Query: 826 IVKEAELRRGG-MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAY 884
++K A+L+ + G G+F KVY+G G VA+K +K K F E
Sbjct: 279 VIKYADLKLNQEVFGEGSFSKVYRGTLHQMGTGTT-EVAVKAMKSIESDAEMKSFFTECS 337
Query: 885 IMASVEHPNLLQLLAVCMTNQMMLITQLMPL---GCLVDYVRTHK----------EKIGS 931
+M +++HPN+L +L +C + + ++P G L DY++ H+ E +
Sbjct: 338 VMQTLKHPNVLGILGMCFDSPDSIPLMVLPFMVNGNLKDYLKKHRGPHLQLETYPENLSL 397
Query: 932 KAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA 991
+ C I RGM+YL ++R VHRDLAARN L+ + +VK+ DFGL + + +
Sbjct: 398 QMLKRICVDITRGMSYLADRRFVHRDLAARNCLLDSALAVKVGDFGLTRDIYLTNYYRAP 457
Query: 992 AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGL 1051
K+P+KW+ E +Q + K+DVW+FGVT WE+ S+G+ PY + + + + +GL
Sbjct: 458 TETKLPVKWMPPEMLQDGVSDEKTDVWSFGVTCWEVFSFGSTPYPGVDNHLMLQHLMSGL 517
Query: 1052 KLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFA 1089
+L +P +C +IY +M CW + + RPTF +L F+
Sbjct: 518 RLQKPLLCPDEIYTLMARCWSSNPEDRPTFNELFKEFS 555
>UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming protein
SEA; n=6; root|Rep: Tyrosine-protein kinase transforming
protein SEA - Avian erythroblastosis virus (strain S13)
Length = 370
Score = 179 bits (436), Expect = 4e-43
Identities = 103/283 (36%), Positives = 153/283 (54%), Gaps = 13/283 (4%)
Query: 810 EPLRPTNVKPNLAKLRIVKEAEL--RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVL 867
E LRP ++ K ++ E L R ++G G FG VY G ++ + A+K L
Sbjct: 38 EDLRPELLEE--VKDILIPEERLITHRSRVIGRGHFGSVYHGTYMDPLLG-NLHCAVKSL 94
Query: 868 KETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ--MMLITQLMPLGCLVDYVRTH 925
T +EFL E +M HP +L LL VC+ +++ M G L +VR
Sbjct: 95 HRITYLEEVEEFLREGILMKGFHHPQVLSLLGVCLPRHGLPLVVLPYMRHGDLRHFVRAQ 154
Query: 926 KEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDIN 985
+ K + + Q+A GM YL +K+ VHRDLAARN ++ +VK+ DFGLA+ D+
Sbjct: 155 ERSPTVKELIGFGLQVALGMEYLAQKKFVHRDLAARNCMLDETLTVKVADFGLAR--DVF 212
Query: 986 EDEYKAAG----GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISAR 1041
EY + K+P++W+ALE +Q + FT KSDVW+FGV +WE+L+ GA PY +
Sbjct: 213 GKEYYSIRQHRHAKLPVRWMALESLQTQKFTTKSDVWSFGVLMWELLTRGASPYPEVDPY 272
Query: 1042 NVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
++ + G +LPQP C +Y VM+SCW + RP+F L
Sbjct: 273 DMARYLLRGRRLPQPQPCPDTLYGVMLSCWAPTPEERPSFSGL 315
>UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6;
Endopterygota|Rep: Tyrosine-protein kinase Src64B -
Drosophila melanogaster (Fruit fly)
Length = 552
Score = 179 bits (435), Expect = 6e-43
Identities = 111/301 (36%), Positives = 169/301 (56%), Gaps = 16/301 (5%)
Query: 794 KEAVKMTMVLTG-CEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWV 852
K A+ + +L+ C +P + ++ P L + +E++ LG G FG+V+ G W
Sbjct: 246 KNALGLCHILSRPCPKPQP-QMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKW- 303
Query: 853 PEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQ- 911
I VA+K L+E G ++ FL+EA IM H L+ L AVC + + I Q
Sbjct: 304 ----RNSIDVAVKTLRE--GTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQE 357
Query: 912 LMPLGCLVDYVRTHKEK-IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNS 970
M G L+D++R + + + + TQ+A GM YLE K+L+HRDLAARNVL+ N
Sbjct: 358 YMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNV 417
Query: 971 VKITDFGLAKLLDINEDEY-KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILS 1029
KI DFGLA++ I +DEY G + P+KW A E I + F+ KSDVW++G+ + E+ +
Sbjct: 418 AKICDFGLARV--IADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFT 475
Query: 1030 YGARPYENISARNVPELIENGLKLPQPS--ICTLDIYCVMVSCWMLDADSRPTFKQLADT 1087
YG PY + +R V E IE G ++P+P+ +IY +++ CW + RPTF+ L
Sbjct: 476 YGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHY 535
Query: 1088 F 1088
F
Sbjct: 536 F 536
>UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase FER;
n=109; root|Rep: Proto-oncogene tyrosine-protein kinase
FER - Homo sapiens (Human)
Length = 822
Score = 179 bits (435), Expect = 6e-43
Identities = 94/261 (36%), Positives = 148/261 (56%), Gaps = 9/261 (3%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYI 885
I+ ++ G +LG G FG+VYKG K VA+K KE +FL+EA I
Sbjct: 557 ILSHEDVILGELLGKGNFGEVYKGTLKD-----KTSVAVKTCKEDLPQELKIKFLQEAKI 611
Query: 886 MASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARG 944
+ +HPN+++L+ VC Q + +I +L+ G + ++R K+++ K + + A G
Sbjct: 612 LKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAG 671
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGK-MPIKWLAL 1003
M YLE K +HRDLAARN LV N +KI+DFG+++ D Y ++G K +PIKW A
Sbjct: 672 MLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQED--GGVYSSSGLKQIPIKWTAP 729
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDI 1063
E + + ++ +SDVW+FG+ +WE S G PY ++ + E +E G ++ P C DI
Sbjct: 730 EALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDI 789
Query: 1064 YCVMVSCWMLDADSRPTFKQL 1084
+M+ CW ++RP F +L
Sbjct: 790 SKIMMKCWDYKPENRPKFSEL 810
>UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte
receptor tyrosine protein kinase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to leukocyte receptor
tyrosine protein kinase - Nasonia vitripennis
Length = 1472
Score = 178 bits (434), Expect = 8e-43
Identities = 94/270 (34%), Positives = 151/270 (55%), Gaps = 15/270 (5%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG GAFG+V++GV+ + + PVA+K L + + +F+ EA IM+ EHPN++Q
Sbjct: 926 LGQGAFGEVFQGVY-KYSRSEEHPVAVKTLPSVSTSQAEADFMMEALIMSKFEHPNIVQF 984
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEK------IGSKAFLNWCTQIARGMAYLEE 950
+ + ++ +L+ G L +++R + + + ++ + +A+G Y+EE
Sbjct: 985 IGISFDKHPRYIVLELLAGGDLKNFLREERPRPDRPTTLTMQSLIMCAYDVAKGCKYMEE 1044
Query: 951 KRLVHRDLAARNVLVQTPNS---VKITDFGLAKLLDINEDEYKAAGGK--MPIKWLALEC 1005
R +HRD+AARN L+ VKI DFG+A+ DI +Y GGK +PIKW+ E
Sbjct: 1045 ARFIHRDIAARNCLLSCKGPGRVVKIADFGMAR--DIYRSDYYRKGGKAMLPIKWMPPES 1102
Query: 1006 IQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYC 1065
IFT K+DVWAFGV +WEI+S+G PY + R V ++ +G +L +P+ C IY
Sbjct: 1103 FLDGIFTTKTDVWAFGVLLWEIMSFGYMPYTGCANREVMSMVTSGGRLERPAGCPDPIYG 1162
Query: 1066 VMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
+M CW + RP+F + + +DP
Sbjct: 1163 IMTRCWHPHPEERPSFSSIVERIGYCLQDP 1192
>UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca
CG10244-PA; n=3; Endopterygota|Rep: PREDICTED: similar to
Cad96Ca CG10244-PA - Apis mellifera
Length = 657
Score = 178 bits (434), Expect = 8e-43
Identities = 95/280 (33%), Positives = 160/280 (57%), Gaps = 12/280 (4%)
Query: 837 MLGFGAFGKVYKGVWVP-EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVE-HPNL 894
+LG G FG+V+K + +G++ I VA+K LKE + +E +M +++ HPN+
Sbjct: 364 ILGEGCFGQVWKCEALDIDGKSGAIIVAVKTLKENATERERLDLAQELRVMKNLDPHPNV 423
Query: 895 LQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEK-------IGSKAFLNWCTQIARGMA 946
++LL C + M +I + + G L ++R +E+ + S+ + QIA+GM
Sbjct: 424 VRLLGCCTEREPMFVILEYVSGGKLQSFLRASREERNHGGPGLTSRDLTGFVYQIAKGME 483
Query: 947 YLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECI 1006
YL K ++HRDLAARN+L+ + K+ DFG A+ + N+ + + G++PI+W+A E +
Sbjct: 484 YLASKGIIHRDLAARNILIDENRACKVADFGFARDVAANQIYERKSEGRLPIRWMAPESL 543
Query: 1007 QHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCV 1066
IF+ KSD+W+FGV IWEI++ G+ PY ++A V I+ G +L +P C ++Y +
Sbjct: 544 YDNIFSVKSDIWSFGVLIWEIVTLGSTPYPGLAAAEVMRRIKEGYRLDRPEHCKRELYNI 603
Query: 1067 MVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKF 1106
M CW D RP+F +L + D Y+ + D+F
Sbjct: 604 MYYCWDKDPACRPSFGELVSLTEGLLLDETDYIEL--DRF 641
>UniRef50_Q4S1M5 Cluster: Chromosome 6 SCAF14768, whole genome shotgun
sequence; n=5; Euteleostomi|Rep: Chromosome 6 SCAF14768,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 1379
Score = 178 bits (433), Expect = 1e-42
Identities = 88/236 (37%), Positives = 136/236 (57%), Gaps = 3/236 (1%)
Query: 858 VKIPVAIKVLKETT-GANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLG 916
+++ VA+K LK ++ +F+ E M S+ H NL++L + +T M ++ +L PLG
Sbjct: 208 LQLTVAVKCLKANVLDSDGLDDFIREVNAMHSLSHQNLIRLHGIVLTQPMKMVVELAPLG 267
Query: 917 CLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDF 976
L+D +R + I + + Q+A GM+YLE+KR +HRDLAARNVL+ T +VKI DF
Sbjct: 268 SLLDRLRKRQGHILISSLCTYAVQVACGMSYLEQKRFLHRDLAARNVLLSTNETVKIGDF 327
Query: 977 GLAKLLDINEDEY-KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPY 1035
GL + L + D+Y G K+P W A E ++ R F+H SD W GVT+WE+ ++G P+
Sbjct: 328 GLMRALPTHTDQYIMEEGHKIPFPWCAPESLKSRTFSHASDTWMIGVTLWEMFTHGQEPW 387
Query: 1036 ENISARNVPELIE-NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
++ + ++ +L +P C D Y VM+ CW + RPTF L D E
Sbjct: 388 LGLNGSQILHKVDVEAERLCKPEDCPQDTYNVMLQCWSPKPEDRPTFVALRDFLLE 443
>UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1002
Score = 178 bits (433), Expect = 1e-42
Identities = 93/271 (34%), Positives = 149/271 (54%), Gaps = 4/271 (1%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+ + ++ ++G G FG+V +G + G+ VA+K LK FL EA M
Sbjct: 610 IDQTRIKIDSVIGRGEFGEVCRGKMLT-GKTTT-SVAVKRLKHGASLIDHTNFLREACTM 667
Query: 887 ASVEHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGM 945
A + PN++QL V + M+IT+ M G L +++ + L IA GM
Sbjct: 668 AQFKDPNIIQLKGVVTKSIPAMIITEFMEHGSLDKFLQARSGQPTVLQLLEMLRGIASGM 727
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDIN-EDEYKAAGGKMPIKWLALE 1004
YL + VHRDLAARN+LV + K++DFGL++ L+ + + Y GGK+ ++W A E
Sbjct: 728 KYLSSMKYVHRDLAARNILVNSQLVCKVSDFGLSRTLENDPQATYTTQGGKIALRWTAPE 787
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
I+ R FT SDVW++G+ +WE++SYG +PY ++S V E++E+G +LP P C ++
Sbjct: 788 SIRCRQFTSASDVWSYGIVMWEVMSYGEKPYWDMSNEVVTEVLEDGYRLPSPEGCPTPVH 847
Query: 1065 CVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
+M+ CW + RPT ++ T + P
Sbjct: 848 SLMLKCWSYEPKRRPTLLEIIKTLDHFIKQP 878
>UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-oncogene
c-ros-1 protein precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to proto-oncogene c-ros-1 protein
precursor - Apis mellifera
Length = 2105
Score = 177 bits (432), Expect = 1e-42
Identities = 102/268 (38%), Positives = 150/268 (55%), Gaps = 13/268 (4%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
++ ++ LG GAFG+V++G PVAIK L++ A EFL+EA +M
Sbjct: 1802 IRREQITLAKFLGSGAFGEVFQGNAKDLERPGITPVAIKTLRKGASAQEKTEFLQEARLM 1861
Query: 887 ASVEHPNLLQLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKA-------FLNWC 938
+ H ++L+LL VC+ T+ +L+ +LM G L+ Y+R + S + L C
Sbjct: 1862 SHFRHKHVLRLLGVCLDTDPPLLVLELMEAGDLLSYLRASRSLQPSDSHALRLQDLLAMC 1921
Query: 939 TQIARGMAYLEEKRLVHRDLAARNVLVQTPNS----VKITDFGLAKLLDINEDEYKAAGG 994
+ARG YLEE VHRDLA RN LV + VKI DFGLA+ + N+ K G
Sbjct: 1922 EDVARGCRYLEELHFVHRDLACRNCLVSAKDRENRVVKIGDFGLARDIYKNDYYRKEGEG 1981
Query: 995 KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLP 1054
+P++W+A E + +FT +SDVWAFGV +WEI S G +PY + V + G +L
Sbjct: 1982 LLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQQPYPARTNIEVLHHVRAGGRLS 2041
Query: 1055 QPSICTLDIYCVMVSCWMLDADSRPTFK 1082
+P C L ++ +M+ CW D D+RP+FK
Sbjct: 2042 KPLNCPLALHQLMLRCWS-DVDTRPSFK 2068
>UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin
receptor; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to insulin receptor - Tribolium castaneum
Length = 1351
Score = 177 bits (432), Expect = 1e-42
Identities = 116/363 (31%), Positives = 186/363 (51%), Gaps = 29/363 (7%)
Query: 745 PYCSEHANDIPTATARTSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLT 804
PY + + P+ T T V ++ILVI L +LA+ + F +K KA KE++++ +
Sbjct: 905 PYAYFYIEERPSNTYVTLIVCMLILVI----LQILALCAFCFYKKKKADKESMRLIPSVN 960
Query: 805 GCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAI 864
P + K+ +++E LG G+FG VY+G+ +I A+
Sbjct: 961 PEYVPSVYVPDEWEVPRKKIELIRE--------LGQGSFGMVYEGIAQDVRGKAQIKCAV 1012
Query: 865 KVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVR 923
K + E EFL EA +M + + ++++LL V Q ++I +LM G L Y+R
Sbjct: 1013 KTVNEHATNRERLEFLNEASVMKAFDTAHVVRLLGVVSQGQPTLVIMELMANGDLKTYLR 1072
Query: 924 TH------------KEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSV 971
+H K+ K L +IA GMAYL K+ VHRDLAARN +V +V
Sbjct: 1073 SHRPDAEVYDPATAKQPPTLKQILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTV 1132
Query: 972 KITDFGLAKLLDINEDEY--KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILS 1029
KI DFG+ + DI E +Y K G +P++W+A E ++ +FT SDVW++GV +WE+ +
Sbjct: 1133 KIGDFGMTR--DIYETDYYRKGTKGLLPVRWMAPESLKDGVFTSNSDVWSYGVVLWEMAT 1190
Query: 1030 YGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFA 1089
++PY+ +S V + +G + +P C +Y +M CW +RP+F +L
Sbjct: 1191 LASQPYQGLSNDQVLRYVIDGGVMERPENCPDKLYTLMRYCWQHKPSARPSFLKLCSLLL 1250
Query: 1090 EMA 1092
E A
Sbjct: 1251 EDA 1253
Score = 70.1 bits (164), Expect = 4e-10
Identities = 68/231 (29%), Positives = 93/231 (40%), Gaps = 34/231 (14%)
Query: 167 ENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRN----FYDEGT 222
++CQK T C C +CC+ C GGC+ C C+N F +
Sbjct: 220 QHCQKICPTKCKHSCNANL-------ECCDESCLGGCSINDTKLCTVCKNLSMGFGAKKQ 272
Query: 223 CSQECPS--MQIYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKD-NGACVRSCPPNKTA 279
C CP Q + K + PE K N +C+ CPPN +
Sbjct: 273 CMSSCPPDYYQYLERRCILKNECKDMKRPLNFQ-QQGGPEKPFKIFNNSCILECPPNYMS 331
Query: 280 VNGECIPCVGTCPKTCRAEKPIHSGNID-SFKDCTIIDGSIEILEMTFTGFQQVNQDYSF 338
+ CIPC G C K C A + S N+ K CT I S+EI G VN+
Sbjct: 332 NDTHCIPCQGNCIKKC-AGVNVDSINLARQLKGCTHITSSLEI--QIRGGRNVVNE---- 384
Query: 339 GERYPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQV 389
+E E + E+ GYL V P SL++ +NL+VI GRQ+
Sbjct: 385 ------LE----ESLGMIEEIDGYLKVVRSFP-LVSLNFLKNLKVIHGRQL 424
Score = 49.2 bits (112), Expect = 8e-04
Identities = 35/121 (28%), Positives = 62/121 (51%), Gaps = 11/121 (9%)
Query: 16 DRFTNCTYVDGNLELTWLEN-ESMDLSFLKY--IREVTGYVLISHVKVHKIV---LPQLQ 69
+R C V+G +++ +N +LS L + + E+T Y+L+ V + + P L
Sbjct: 43 NRLKGCHVVEGFVQILLFDNVNETELSLLSFPNLTEITDYLLLYRVNGLRSIGQLFPNLS 102
Query: 70 IIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSVGIYSNFNLCHVKTINWDE 129
+IRGR+ F F + MS+ + L +L D+ +G + I N +LC V +I+W+
Sbjct: 103 VIRGRSTFYTY----SFVVF-EMSSLQEIGLYSLTDITRGLIRIDKNPSLCFVNSIDWEA 157
Query: 130 I 130
I
Sbjct: 158 I 158
>UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32;
Euteleostomi|Rep: Tyrosine-protein kinase HCK - Homo
sapiens (Human)
Length = 526
Score = 177 bits (432), Expect = 1e-42
Identities = 94/249 (37%), Positives = 147/249 (59%), Gaps = 11/249 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG+V+ + N VA+K +K G+ + + FL EA +M +++H L++L
Sbjct: 268 LGAGQFGEVWMATY-----NKHTKVAVKTMKP--GSMSVEAFLAEANVMKTLQHDKLVKL 320
Query: 898 LAVCMTNQMMLITQLMPLGCLVDYVRTHK-EKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
AV + +IT+ M G L+D++++ + K +++ QIA GMA++E++ +HR
Sbjct: 321 HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR 380
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALECIQHRIFTHKS 1015
DL A N+LV KI DFGLA++++ NE Y A G K PIKW A E I FT KS
Sbjct: 381 DLRAANILVSASLVCKIADFGLARVIEDNE--YTAREGAKFPIKWTAPEAINFGSFTIKS 438
Query: 1016 DVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDA 1075
DVW+FG+ + EI++YG PY +S V +E G ++P+P C ++Y +M+ CW
Sbjct: 439 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRP 498
Query: 1076 DSRPTFKQL 1084
+ RPTF+ +
Sbjct: 499 EERPTFEYI 507
>UniRef50_Q4SF69 Cluster: Chromosome undetermined SCAF14608, whole
genome shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome undetermined SCAF14608, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 559
Score = 177 bits (431), Expect = 2e-42
Identities = 105/294 (35%), Positives = 154/294 (52%), Gaps = 27/294 (9%)
Query: 823 KLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSK--EFL 880
+ R +++EL G LG G+FG V KG W V + VA+K L+ + T +FL
Sbjct: 148 RARRARDSELLLGEKLGSGSFGVVRKGEWHAPAGRV-LTVAVKSLRSSVSRQTDMLTDFL 206
Query: 881 EEAYIMASVEHPNLLQLLAVCMTNQMMLI----------------------TQLMPLGCL 918
+E M S++HPN+++L V +T + ++ T+L PLG L
Sbjct: 207 QEVTTMQSLDHPNIIRLYGVVLTQPLKMVKPSLLALSLLPGMFRSASALQVTELAPLGSL 266
Query: 919 VDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGL 978
D + + + + TQI GM YLE +RL+HRDLAARN+L+ + VKI DFGL
Sbjct: 267 YDTLHARQYEYPLVRLWLFTTQIVSGMEYLETRRLIHRDLAARNILLASREMVKIGDFGL 326
Query: 979 AKLLDINEDEY-KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYEN 1037
+ L D Y +A ++P W A E ++ F+H SDVW FGVT+WE+ +Y P+
Sbjct: 327 MRGLSQEVDHYVMSAHRRIPFAWCAPESLRVGSFSHSSDVWMFGVTMWEMFTYCEEPWFG 386
Query: 1038 ISARNVPELIE-NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
+S R + +E G +L +P C ++Y VM CWM + RP F QL AE
Sbjct: 387 LSGRQILWRVEREGERLEKPPDCPQELYAVMRKCWMCNPHDRPNFTQLGTLVAE 440
>UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Rep:
Tyrosine kinase - Sycon raphanus
Length = 879
Score = 177 bits (431), Expect = 2e-42
Identities = 95/279 (34%), Positives = 159/279 (56%), Gaps = 12/279 (4%)
Query: 812 LRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETT 871
LR KP+L + I + + G +G G FG V+KG + + VA+K +
Sbjct: 601 LRQPVKKPDLREYNISHD-NILIGEKIGKGNFGDVFKGYL----KTHNMEVAVKSCRSED 655
Query: 872 GANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEK-I 929
+ K FL+EA I+ HPN+++L+ VC + + +I +LM G + ++R + K +
Sbjct: 656 FPDKQK-FLQEAEILKQYRHPNIVELIGVCAEKEPLYIIMELMAGGNFLSFLRGPEGKRL 714
Query: 930 GSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY 989
C + A GM +LE++ +HRDLAARN LV N +KI+DFG+++ D + Y
Sbjct: 715 KVNNLTEMCVEAAAGMVFLEQRNCIHRDLAARNCLVGDNNVLKISDFGMSREED--DGIY 772
Query: 990 KAAGG--KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELI 1047
+ G ++PIKW + E + + +T +SDVW++G+ +WE +YG+ PY ++ R E I
Sbjct: 773 TVSSGLKQIPIKWTSPEALNYGRYTTQSDVWSYGILLWETYTYGSGPYPGMNNRETRERI 832
Query: 1048 ENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
E+ ++P+P +C +Y +M+SCW D D RP+F ++ D
Sbjct: 833 ESNYRMPRPELCPHPVYKLMLSCWEYDPDKRPSFAEIYD 871
>UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor b - Nematostella vectensis
Length = 591
Score = 177 bits (431), Expect = 2e-42
Identities = 94/269 (34%), Positives = 157/269 (58%), Gaps = 23/269 (8%)
Query: 836 GMLGFGAFGKVYKG--VWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-EHP 892
G+LG GAFG+V K + +P + VA+K+L E + + + E +M ++ +H
Sbjct: 278 GILGEGAFGRVVKADAIGLPNMP-YRCNVAVKMLXEDATEHELADLVSEMEVMKTIGQHV 336
Query: 893 NLLQLLAVC-MTNQMMLITQLMPLGCLVDYVRTHK--------------EKIGSKAFLNW 937
N++ L+ C + ++ + G L ++R + EK+ +++
Sbjct: 337 NIINLIGACTQKGPLFVVVEYASQGNLRQFLRARRPIPEYANPLTEPPREKLKLVDLVSF 396
Query: 938 CTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY--KAAGGK 995
Q+ARGM YLE K+ +HRDLAARNVLV + +KI DFGLA+ DI++ +Y K G+
Sbjct: 397 SYQVARGMEYLESKKCIHRDLAARNVLVSDNHVIKIADFGLAR--DIHDIDYYRKTTDGR 454
Query: 996 MPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQ 1055
+P+KW+ALE + R++T +SDVWA+G+ +WEI+++G PY I + EL++ G ++ Q
Sbjct: 455 LPVKWMALEALFDRVYTAQSDVWAYGILMWEIVTFGGSPYPGIPLWKLFELLKEGYRMEQ 514
Query: 1056 PSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
P C D+Y +M+ CW + + RPTF ++
Sbjct: 515 PVNCQDDVYALMLRCWHENPNQRPTFAEI 543
>UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to RE05926p, partial -
Strongylocentrotus purpuratus
Length = 859
Score = 177 bits (430), Expect = 2e-42
Identities = 105/302 (34%), Positives = 163/302 (53%), Gaps = 22/302 (7%)
Query: 838 LGFGAFGKVYKGVWVPE-GENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVE-HPNLL 895
LG G+F VYK V + K VA+K LKET N + +E + ++ HPN++
Sbjct: 319 LGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSKELSLYMYLDPHPNIV 378
Query: 896 QLLAVCM-TNQMMLITQLMPLGCLVDYVR--------------THKEK-IGSKAFLNWCT 939
+L C ++ +I + +P L Y+R K+K I L +
Sbjct: 379 NILGCCTDSDPWYIIMEYLPNNNLQGYLRQIRTGESMTADYRNVKKQKDIPPNDLLTFGV 438
Query: 940 QIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIK 999
QIARGM YL ++ +HRDLAARN+L+ K++DFGLA+ L+ + + G++P++
Sbjct: 439 QIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDGQTYEMKSQGRVPVR 498
Query: 1000 WLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSIC 1059
W++ E + H +T +SDVW+F + IWEI++ G+ PY +S++ V + I G +LP+P C
Sbjct: 499 WMSPESLLHNTYTSQSDVWSFAILIWEIVTLGSHPYPGMSSKQVVKEISAGYRLPKPEHC 558
Query: 1060 TLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIP---GDKFMRL-PSYSTQ 1115
+ DIY +M CW +A+ RPTF Q+ M D YLV+ D ++ L P T
Sbjct: 559 SQDIYNLMKECWAYEAEERPTFSQVKVRLENMLADAQGYLVMSDFNDDNYLYLEPDAHTG 618
Query: 1116 DE 1117
DE
Sbjct: 619 DE 620
>UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kinase
BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in
chromosome X protein) (Epithelial and endothelial
tyrosine kinase) (ETK) (NTK38).; n=2; Gallus gallus|Rep:
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)
(Bone marrow tyrosine kinase gene in chromosome X
protein) (Epithelial and endothelial tyrosine kinase)
(ETK) (NTK38). - Gallus gallus
Length = 633
Score = 177 bits (430), Expect = 2e-42
Identities = 94/258 (36%), Positives = 145/258 (56%), Gaps = 9/258 (3%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG G FG V+ G W +G VA+K++KE G + EF+EEA M + HP L++L
Sbjct: 378 LGSGQFGAVHLGKW--KG---LYDVAVKMIKE--GVVSEDEFVEEAQTMMKLNHPKLVRL 430
Query: 898 LAVCMT-NQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
VC + L+ + MP G L+ Y++ H +++ L C + MA+LE +L+HR
Sbjct: 431 YGVCSKLYPIYLVMEYMPNGSLLSYLQIHGKELQPLQLLEICYDVCDAMAFLESCQLIHR 490
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSD 1016
DLAARN LV + +VK++DFG+ K + +++ + G K P+KW A E + F+ KSD
Sbjct: 491 DLAARNCLVDSNLTVKLSDFGMTKYV-LDDLYVSSLGTKFPVKWSAPEVFHYTKFSSKSD 549
Query: 1017 VWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDAD 1076
VWAFG+ +WE+ + G +PYE V E + G +L +P + + Y +M +CW +
Sbjct: 550 VWAFGILMWEVFTLGKQPYELYDNMQVIEKVSQGYRLYRPQLVSDITYQIMYNCWHELPE 609
Query: 1077 SRPTFKQLADTFAEMARD 1094
RP F QL F + +
Sbjct: 610 KRPAFHQLLSFFEDAVEE 627
>UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular
organisms|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 177 bits (430), Expect = 2e-42
Identities = 90/266 (33%), Positives = 152/266 (57%), Gaps = 7/266 (2%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+K +++ G LG GAFG V++ +G+ VA+K + T + K FL+EA I+
Sbjct: 629 LKHEDIKMGRKLGKGAFGDVWEAALKGQGK-----VAVKTCRSTDVPDREK-FLQEAEIL 682
Query: 887 ASVEHPNLLQLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGM 945
+HPN+++L+ V T ++++ +LMP G L+DY+R ++ L+ GM
Sbjct: 683 KQYDHPNIVKLIGVSWDTEPVLIVMELMPGGSLLDYLRKKAAQMTKGKLLHMSIDACGGM 742
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALEC 1005
YLE K +HRDLAARN LV + VKI+DFG+++ + ++ ++PIKW A E
Sbjct: 743 EYLESKNCIHRDLAARNCLVGENDIVKISDFGMSREEEGGMYTVQSGTRQIPIKWTAPEA 802
Query: 1006 IQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYC 1065
+ + +T SDVW+FGV ++E+ S G+ PY +S +++G ++P P C +I+
Sbjct: 803 LNYGRYTSASDVWSFGVLLYEVFSGGSTPYPGMSNAETRTQVDSGYRMPPPQGCPAEIHQ 862
Query: 1066 VMVSCWMLDADSRPTFKQLADTFAEM 1091
+M CW DA+ RP F + ++ ++
Sbjct: 863 IMQLCWAYDAEDRPKFGAVLESLKKL 888
>UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae|Rep:
Tyrosine-protein kinase - Aedes aegypti (Yellowfever
mosquito)
Length = 747
Score = 177 bits (430), Expect = 2e-42
Identities = 100/270 (37%), Positives = 158/270 (58%), Gaps = 15/270 (5%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+K +L+ +G G FG V G+ +GE V A+KVLK+ A S +FL EA +M
Sbjct: 484 IKMEDLQLKENIGKGEFGDVMLGIL--KGEKV----AVKVLKDAGRA--SNKFLAEAGVM 535
Query: 887 ASVEHPNLLQLLAVCMTNQMM-LITQLMPLGCLVDYVRTH-KEKIGSKAFLNWCTQIARG 944
++EH NL++ + + ++ + L+T+ M G LVDY+R+ ++ I + +N+ G
Sbjct: 536 TTLEHENLVKFIGLVFHDKYIYLVTEYMSKGSLVDYLRSRGRQHITRRDQINFAFDTCSG 595
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALE 1004
M YLE K+++HRDLAARNVL+ K++DFGLA+ ++ Y A K+PIKW A E
Sbjct: 596 MEYLEMKKVIHRDLAARNVLISEECVAKVSDFGLAR-----DERYTADISKLPIKWTAPE 650
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
++ F++K+D+W+FG+ +WEI S+G PY I +V + + +G K+ P C +IY
Sbjct: 651 ALKEGKFSNKTDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVGSGYKMEAPEGCPPEIY 710
Query: 1065 CVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
+M W L + RPTF +L A R+
Sbjct: 711 EMMRQAWDLVPEKRPTFAELKRRLAVCKRE 740
>UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 283
Score = 177 bits (430), Expect = 2e-42
Identities = 99/274 (36%), Positives = 153/274 (55%), Gaps = 16/274 (5%)
Query: 825 RIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAY 884
+I +EA + G LG G FGKV +G V E + ++ A+K LK T + K+ L E
Sbjct: 1 QIPREA-VELGRTLGEGEFGKVIEGN-VTEPDGTRVHCAVKKLKRTATESDWKDLLNELD 58
Query: 885 IMASV-EHPNLLQLLAVCMTNQ--MMLITQLMPLGCLVDYVRTHKEK-----------IG 930
IM V EHPN++ L+ C + +M+I + G L+ Y++ + K I
Sbjct: 59 IMVQVGEHPNIVNLIGACSDPEGPLMVIVEFCGNGNLLHYLQKNSNKNYSNLHEYVLTIP 118
Query: 931 SKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYK 990
++ L +A GMA+LE+ R VHRDLAARNVL+ + K++DFGL++ + N K
Sbjct: 119 ARERLRIAADVASGMAHLEKMRCVHRDLAARNVLLDEALTAKVSDFGLSRDIYTNSVYEK 178
Query: 991 AAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENG 1050
GGK+P KW+A+E I+ ++T SD W+FGV +WEI + G PY + + + ++ G
Sbjct: 179 TTGGKLPAKWMAIESIEAGLYTSHSDAWSFGVLLWEIETGGCIPYPTFTVQEMLNSLKKG 238
Query: 1051 LKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
+L +P C +Y +M+SCW D RP F ++
Sbjct: 239 YRLEKPPYCLEPLYTLMLSCWSADPALRPHFVEI 272
>UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosine
kinase, non-recepTor, 2 isoform 1; n=1; Takifugu
rubripes|Rep: Homolog of Homo sapiens "Tyrosine kinase,
non-recepTor, 2 isoform 1 - Takifugu rubripes
Length = 767
Score = 176 bits (429), Expect = 3e-42
Identities = 97/269 (36%), Positives = 149/269 (55%), Gaps = 18/269 (6%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSK--EFLEEA 883
++++ EL G LG G+FG + VA+K L+ + T +FL+E
Sbjct: 144 LIQDGELLLGEKLGSGSFGV--------------LTVAVKTLRNSVSRQTDTLTDFLQEV 189
Query: 884 YIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIAR 943
M +++HPN+++L V +T + ++T+L LG L D +R + + + TQIA
Sbjct: 190 TTMQALDHPNIIRLYGVVLTQPLKMVTELASLGSLYDTLRARQFEYPLVRLWLFATQIAS 249
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWLA 1002
GM YLE +RL+HRDLAARN+L+ + VKI DFGL + L D Y +A ++P W A
Sbjct: 250 GMDYLETRRLIHRDLAARNILLASREMVKIGDFGLMRGLSQEVDHYVMSAHRRIPFAWCA 309
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE-NGLKLPQPSICTL 1061
E ++ F+H SDVW FGVT+WE+ +Y P+ ++ R + +E G +L +P C
Sbjct: 310 PESLRVGSFSHSSDVWMFGVTMWEMFTYCEEPWFGLTGRQILWRVEREGERLEKPPDCPQ 369
Query: 1062 DIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
++Y VM CW + + RP F QL AE
Sbjct: 370 ELYVVMRKCWACNPNDRPNFSQLGMLVAE 398
>UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep: MBTK3
- Monosiga brevicollis
Length = 357
Score = 176 bits (429), Expect = 3e-42
Identities = 100/260 (38%), Positives = 152/260 (58%), Gaps = 12/260 (4%)
Query: 830 AELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV 889
++L G +G G FG+VY + +G V A+K +++ A EF E+ +M ++
Sbjct: 75 SDLIAGKPIGAGQFGQVYLAKY--KGNQV----AVKTVRQGASAEDIAEFTAESEVMLAL 128
Query: 890 EHPNLLQLLAVCMTNQMML-ITQLMPLGCLVDYVRTHKEKIGSKAFLN---WCTQIARGM 945
H L+QLL V M + L + + M G L + ++T KEK A+L + QI+RGM
Sbjct: 129 RHNCLVQLLGVSMQQRPWLCVIEFMKYGDLREVLKTCKEKSLRLAYLEQLAFAVQISRGM 188
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAG-GKMPIKWLALE 1004
A++ ++R VH DLAARNVL+ N K+ DFGL + D +D Y K+PI+W+A+E
Sbjct: 189 AFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTAKLPIRWMAIE 248
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSI-CTLDI 1063
++ ++F+ KSDVWAFGVT+ EI +YGA PY + R+V + I +G +L +P D
Sbjct: 249 AMKTKVFSEKSDVWAFGVTLHEIAAYGALPYAGVKNRDVSKHILDGNRLAKPEDGMQDDF 308
Query: 1064 YCVMVSCWMLDADSRPTFKQ 1083
+ + SCW D RPTFK+
Sbjct: 309 FALAESCWQDDPAVRPTFKE 328
>UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4;
Endopterygota|Rep: Tyrosine-protein kinase - Aedes
aegypti (Yellowfever mosquito)
Length = 959
Score = 176 bits (429), Expect = 3e-42
Identities = 105/278 (37%), Positives = 161/278 (57%), Gaps = 26/278 (9%)
Query: 830 AELRRGGMLGFGAFGKVY--KGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMA 887
++L G LG GAFGKV + + +G+ + VA+K+LKE K+ + E +M
Sbjct: 624 SKLVLGKSLGEGAFGKVVMAEANGLVKGQASTV-VAVKMLKEGHTDADVKDLVCEMEVMK 682
Query: 888 SV-EHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTH--------------KEK--I 929
+ +H N++ LL C + + +I + P G L D++R+H KEK +
Sbjct: 683 MIGKHVNIINLLGCCCKDGPLYVIVEYAPHGNLKDFLRSHRFGTANYEDMISGEKEKKIL 742
Query: 930 GSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY 989
K +++ QIARGM +L +R +HRDLAARNVLV +KI DFGLA+ DI+ EY
Sbjct: 743 TQKELISFAYQIARGMEHLASRRCIHRDLAARNVLVSDGYVMKIADFGLAR--DIHSQEY 800
Query: 990 --KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISA-RNVPEL 1046
K GK+PI+W+A E ++ + + +SDVW+FGV +WEI++ G PY +I N+ E
Sbjct: 801 YRKTTTGKLPIRWMAPESLEEKFYDSQSDVWSFGVLLWEIMTLGGNPYSSIPTWDNLLEH 860
Query: 1047 IENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
++ G +L QP +C++DIY M CW + RPTF ++
Sbjct: 861 LKKGKRLEQPPLCSIDIYLFMRECWHYRPEERPTFSEI 898
>UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles sp.|Rep: Tyrosine-protein kinase receptor -
Anopheles sp
Length = 863
Score = 176 bits (429), Expect = 3e-42
Identities = 92/256 (35%), Positives = 148/256 (57%), Gaps = 10/256 (3%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
+LG GAFG+VY+GV + VAIK LK+ + +EFL+EA +M++ +H ++ +
Sbjct: 456 LLGSGAFGEVYEGVVKGVDGEAETRVAIKTLKKGAKLHEKQEFLQEAQLMSNFKHKHITR 515
Query: 897 LLAVCM-TNQMMLITQLMPLGCLVDYVRTHK-----EKIGSKAFLNWCTQIARGMAYLEE 950
LL VC+ + +++I +LM G L+ Y+ ++ ++ C +A G YLEE
Sbjct: 516 LLGVCLEADALLIIMELMQGGDLLSYLPAQPLPGQAARLTMLDLISMCQDVASGCRYLEE 575
Query: 951 KRLVHRDLAARNVLVQTPNS----VKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECI 1006
VHRDLA RN LV + + VKI DFGLA+ + N+ K G +P++W++ E +
Sbjct: 576 MHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSPESL 635
Query: 1007 QHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCV 1066
+FT +SD+WAFGV +WEI++ G +PY+ + V + G L +P +C ++Y +
Sbjct: 636 VDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNVEVLNHVREGGHLDRPKVCPNEMYEL 695
Query: 1067 MVSCWMLDADSRPTFK 1082
M CW + RPTF+
Sbjct: 696 MKYCWKFSPEERPTFR 711
>UniRef50_UPI00006A1E7A Cluster: Non-receptor tyrosine-protein kinase
TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).; n=3;
Xenopus tropicalis|Rep: Non-receptor tyrosine-protein
kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1). -
Xenopus tropicalis
Length = 673
Score = 176 bits (428), Expect = 4e-42
Identities = 97/278 (34%), Positives = 153/278 (55%), Gaps = 9/278 (3%)
Query: 814 PTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGA 873
P ++P+ + ++ E +L LG G FG V +G W E V VA+K L+ +
Sbjct: 97 PLRMEPDSSMKCLINERDLSLFERLGDGCFGVVRRGEWRVSSEGVN--VAVKYLRSDACS 154
Query: 874 NTS--KEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGS 931
+ ++FL+E M ++HP+L++L V ++ + ++T++ PLG L+D + GS
Sbjct: 155 DPEALQDFLQEVNSMYVLDHPHLIRLYGVVLSKPLKMVTEIAPLGSLLDALHNSYGSCGS 214
Query: 932 KAF-LNW--CTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDE 988
+ L W QIA GM YLE + +HRDLA RNVL+ + + KI DFGL + L + D
Sbjct: 215 FSLPLLWKYSLQIASGMKYLESYKFIHRDLATRNVLLTSEDVAKIGDFGLMRALGGHSDH 274
Query: 989 Y-KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELI 1047
Y + K+P W E ++ F+++SDVW FGVT+WE+ +YG P+ S + + I
Sbjct: 275 YIMSTHRKIPFAWCPPESLKIGAFSNQSDVWMFGVTLWEMFTYGQEPWMGFSGKQILLKI 334
Query: 1048 ENGLK-LPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
+ + L +P C +Y VM CW+ + D RPTF L
Sbjct: 335 DRDRETLERPDDCPQALYEVMKKCWIYEPDQRPTFANL 372
>UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor 1
precursor; n=310; Euteleostomi|Rep: Basic fibroblast
growth factor receptor 1 precursor - Homo sapiens (Human)
Length = 822
Score = 176 bits (428), Expect = 4e-42
Identities = 98/274 (35%), Positives = 151/274 (55%), Gaps = 24/274 (8%)
Query: 835 GGMLGFGAFGKVYKGVWV---PEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-E 890
G LG G FG+V + + N VA+K+LK + + E +M + +
Sbjct: 481 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 540
Query: 891 HPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHK---------------EKIGSKAF 934
H N++ LL C + + +I + G L +Y++ + E++ SK
Sbjct: 541 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 600
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY--KAA 992
++ Q+ARGM YL K+ +HRDLAARNVLV N +KI DFGLA+ DI+ +Y K
Sbjct: 601 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR--DIHHIDYYKKTT 658
Query: 993 GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLK 1052
G++P+KW+A E + RI+TH+SDVW+FGV +WEI + G PY + + +L++ G +
Sbjct: 659 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 718
Query: 1053 LPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
+ +PS CT ++Y +M CW RPTFKQL +
Sbjct: 719 MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE 752
>UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whole
genome shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome undetermined SCAF10323, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 815
Score = 175 bits (427), Expect = 5e-42
Identities = 95/243 (39%), Positives = 140/243 (57%), Gaps = 3/243 (1%)
Query: 837 MLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQ 896
++G G FG+V G G+ +I VAIK LK ++FL EA IM HPN+++
Sbjct: 483 IIGAGEFGEVCSGPLRLPGKR-EILVAIKTLKAGYTEQQRRDFLWEASIMGQFNHPNIIR 541
Query: 897 LLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVH 955
L V ++ +M+IT+ M G L +++ + + + IA GM YL + VH
Sbjct: 542 LEGVVTKSKPVMIITEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGMRYLSDMGYVH 601
Query: 956 RDLAARNVLVQTPNSVKITDFGLAKLL-DINEDEYKAAGGKMPIKWLALECIQHRIFTHK 1014
RDLAARN+LV K++DFGL++ L D E Y GGK+PI+W A E I +R FT
Sbjct: 602 RDLAARNILVDGHLVCKVSDFGLSRALEDDPEAAYTTQGGKIPIRWTAPEAIAYRKFTSA 661
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
SDVW++GV +WE++SYG RPY ++S ++V + +E +LP P C +Y +M CW +
Sbjct: 662 SDVWSYGVVMWEVMSYGERPYWDMSNQDVIKAVEENYRLPGPMDCPESLYQLMTDCWQRE 721
Query: 1075 ADS 1077
S
Sbjct: 722 RTS 724
>UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n=2;
Ascidiacea|Rep: Gamma-carboxyglutamic acid protein 1 -
Ciona intestinalis (Transparent sea squirt)
Length = 556
Score = 175 bits (427), Expect = 5e-42
Identities = 93/279 (33%), Positives = 153/279 (54%), Gaps = 10/279 (3%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
V+ L+ G ++ G FG VY+G + +N VA+K LK ++FL E +M
Sbjct: 167 VERERLQLGEVITSGNFGDVYRGK-LRSRQNTWHDVAVKSLKSLENHEDVEKFLREGVMM 225
Query: 887 ASVEHPNLLQLLAVCMTNQM-------MLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCT 939
++H N+L L+ VC+ ++ ++I M G L ++R + L +C
Sbjct: 226 RGLDHRNVLALIGVCVDGEVERLQTSPLIILPFMENGDLRTFLRDGNNVLTVLKLLKFCK 285
Query: 940 QIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPI 998
+A GM YL EK+ VHRDLAARN +V VK+ DFGL++ L + D Y+++ ++P+
Sbjct: 286 DVAMGMEYLAEKKFVHRDLAARNCMVDKNWCVKVADFGLSRDL-FDRDYYRSSVKTQLPL 344
Query: 999 KWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSI 1058
KW+ E I++ + KSDVW++G+ WEI++ GA PY + A + + + G ++ +P
Sbjct: 345 KWMPPESIKYGRYGEKSDVWSYGIVCWEIMTRGAIPYPTVQAVAILQYLSEGNRMERPEC 404
Query: 1059 CTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGR 1097
C +Y M CW+ D + RPTF++L ++ RD R
Sbjct: 405 CPHKLYKTMEKCWLDDTERRPTFEELVTITTKIVRDARR 443
>UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2;
Eumetazoa|Rep: Tyrosine-protein kinase receptor - Aplysia
californica (California sea hare)
Length = 1145
Score = 175 bits (426), Expect = 7e-42
Identities = 125/364 (34%), Positives = 181/364 (49%), Gaps = 32/364 (8%)
Query: 745 PYCSEHANDIPTATARTSTVLVIILV---IASLFLAVLAIIGYNFRQKAKAKKEAVKMTM 801
P CS++ P+ S L+ IL+ L L +L + F QK+ + +
Sbjct: 487 PKCSDYDEGHPSEADEGSNKLMYILIPSLTVPLALGILLAL-ICFCQKSHNTRASRPNNK 545
Query: 802 VLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVP-EGENVKI 860
E + PL P + ++ R +R LG GAFGKVYKG V GE+
Sbjct: 546 QAQPVEMS-PLNPKSA----SRAREFPMPNIRFLQELGEGAFGKVYKGELVGLYGESSVT 600
Query: 861 PVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLV 919
VAIK LKE +F E +M+ + HPN++ LL VCM + M ++ + M G L
Sbjct: 601 TVAIKTLKENALPKVQNDFRREVDLMSDMRHPNIVCLLGVCMKQEPMCMLFEYMAQGDLH 660
Query: 920 DYVRTH---------KEKIGS--------KAFLNWCTQIARGMAYLEEKRLVHRDLAARN 962
+Y+ +H ++ G+ L+ TQ+A GM YL VHRDLAARN
Sbjct: 661 EYLLSHSPHSDVTAAEDDSGTGGGHILEYSEMLHVSTQVAAGMEYLASHHFVHRDLAARN 720
Query: 963 VLVQTPNSVKITDFGLAKLLDINEDEYKAAGGK--MPIKWLALECIQHRIFTHKSDVWAF 1020
+LV +VKI+DFGL++ D+ +Y K +P++W+ E I + FT SDVWAF
Sbjct: 721 ILVADGLTVKISDFGLSR--DVYSSDYYRVQSKSLLPVRWMPPEAILYGKFTTDSDVWAF 778
Query: 1021 GVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPT 1080
GV +WE+ SYG +PY S + V E+I + L P C IY +MV CW RP
Sbjct: 779 GVVLWEVFSYGLQPYYGFSNQEVIEMIRSRQILGCPEECPARIYGLMVECWHEMPARRPP 838
Query: 1081 FKQL 1084
F+++
Sbjct: 839 FREI 842
>UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Rep:
Isoform of FGFR2 - Homo sapiens (Human)
Length = 709
Score = 175 bits (426), Expect = 7e-42
Identities = 113/351 (32%), Positives = 183/351 (52%), Gaps = 36/351 (10%)
Query: 831 ELRRGGMLGFGAFGKVY--KGVWVPEGENVK-IPVAIKVLKETTGANTSKEFLEEAYIMA 887
+L G LG G FG+V + V + + + + + VA+K+LK+ + + E +M
Sbjct: 368 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 427
Query: 888 SV-EHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHK---------------EKIG 930
+ +H N++ LL C + + +I + G L +Y+R + E++
Sbjct: 428 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 487
Query: 931 SKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY- 989
K ++ Q+ARGM YL ++ +HRDLAARNVLV N +KI DFGLA+ DIN +Y
Sbjct: 488 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR--DINNIDYY 545
Query: 990 -KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE 1048
K G++P+KW+A E + R++TH+SDVW+FGV +WEI + G PY I + +L++
Sbjct: 546 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 605
Query: 1049 NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVI-PGDKFM 1107
G ++ +P+ CT ++Y +M CW RPTFKQL + D R L + ++++
Sbjct: 606 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE-------DLDRILTLTTNEEYL 658
Query: 1108 RLPSYSTQDEKEMIRNLSSAMEGPESLVDAD----EYLQPKFKSMTGTVTT 1154
L Q SS G +S+ D E P++ + G+V T
Sbjct: 659 DLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 709
>UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase MER
precursor; n=30; root|Rep: Proto-oncogene
tyrosine-protein kinase MER precursor - Homo sapiens
(Human)
Length = 999
Score = 175 bits (426), Expect = 7e-42
Identities = 98/262 (37%), Positives = 145/262 (55%), Gaps = 13/262 (4%)
Query: 835 GGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLK-ETTGANTSKEFLEEAYIMASVEHPN 893
G +LG G FG V +G E + + VA+K +K + + +EFL EA M HPN
Sbjct: 590 GKILGEGEFGSVMEGNLKQE-DGTSLKVAVKTMKLDNSSHREIEEFLSEAACMKDFSHPN 648
Query: 894 LLQLLAVC--MTNQ----MMLITQLMPLGCLVDYVRTHKEKIGSK-----AFLNWCTQIA 942
+++LL VC M++Q M+I M G L Y+ + + G K L + IA
Sbjct: 649 VIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 708
Query: 943 RGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLA 1002
GM YL + +HRDLAARN +++ +V + DFGL+K + + + KMP+KW+A
Sbjct: 709 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIA 768
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLD 1062
+E + R++T KSDVWAFGVT+WEI + G PY + + + + +G +L QP C +
Sbjct: 769 IESLADRVYTSKSDVWAFGVTMWEIRTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDE 828
Query: 1063 IYCVMVSCWMLDADSRPTFKQL 1084
+Y +M SCW D RPTF L
Sbjct: 829 LYEIMYSCWRTDPLDRPTFSVL 850
>UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,
isoform B; n=3; Endopterygota|Rep: PREDICTED: similar to
CG8874-PB, isoform B - Tribolium castaneum
Length = 801
Score = 175 bits (425), Expect = 9e-42
Identities = 90/250 (36%), Positives = 143/250 (57%), Gaps = 12/250 (4%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
+G G FG VY+ + +N VA+K + T + K+FL+E I+ +HPN+++L
Sbjct: 545 IGRGNFGDVYRA----QLKNSNDVVAVKTCRVTLPEDHKKKFLQEGRILKQYDHPNIVKL 600
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHR 956
+ +C+ Q +M++ +L+P G L+ ++R K + + C A GM YLE K +HR
Sbjct: 601 IGICVQKQPIMIVMELVPGGSLLTFLRK-KTALTDAQLMKMCLDAAAGMRYLESKNCIHR 659
Query: 957 DLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG--KMPIKWLALECIQHRIFTHK 1014
DLAARN LV N VKI+DFG+++ E+EY + G ++PIKW A E + +T
Sbjct: 660 DLAARNCLVGYNNVVKISDFGMSR----EEEEYIVSDGMKQIPIKWTAPEALNFGKYTSL 715
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
DVW++G+ WEI S G PY +S E I+ G ++P P ++Y +M+ CW
Sbjct: 716 CDVWSYGILCWEIFSRGGTPYSGLSNSKAREKIDAGYRMPAPDNTPDEMYRLMLRCWEYK 775
Query: 1075 ADSRPTFKQL 1084
++RP F+Q+
Sbjct: 776 PENRPNFEQI 785
>UniRef50_O61460 Cluster: Ephrin receptor 1 precursor; n=3;
Caenorhabditis|Rep: Ephrin receptor 1 precursor -
Caenorhabditis elegans
Length = 1122
Score = 175 bits (425), Expect = 9e-42
Identities = 115/326 (35%), Positives = 165/326 (50%), Gaps = 20/326 (6%)
Query: 862 VAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVD 920
VAIK LK + A EFL EA IM HPN+++L+ V + + +M++ + M G L
Sbjct: 745 VAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQ 804
Query: 921 YVRTHKEKIGSKAFLNWCTQ----IARGMAYLEEKRLVHR-----DLAARNVLVQTPNSV 971
++R ++ G K T+ IA GM YL + VHR DLAARNVL+
Sbjct: 805 FLRNTDQR-GEKVHWEKITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMELRC 863
Query: 972 KITDFGLAKLLDIN----EDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEI 1027
KI DFGL++ + E EY GGK+P++W A E I HR FT SDVW+FGV IWE+
Sbjct: 864 KIADFGLSRGVRSEGSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEV 923
Query: 1028 LSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADT 1087
S+G RPY + + + V + G +LP P C + +Y + CW ++ RPTF QL T
Sbjct: 924 CSFGERPYWDWTNQKVISEVMIGYRLPPPMDCPMGLYRIAQWCWKMERHERPTFTQLLAT 983
Query: 1088 FAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPES---LVDADEYL-QP 1143
F + P PG+ R+ S S + + N+ P S + D++L Q
Sbjct: 984 FHKYILQPTLIEHDPGELPRRVQSQSALNTYGSV-NVGVVPTPPSSAAPMPSLDDFLRQI 1042
Query: 1144 KFKSMTGTVTTNSALSAGMETQTSSL 1169
+ G + +N+ S TS L
Sbjct: 1043 GLNHVYGQLVSNNIHSVSDLANTSHL 1068
>UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2
precursor; n=11; Eumetazoa|Rep: Fibroblast growth factor
receptor 2 precursor - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 817
Score = 175 bits (425), Expect = 9e-42
Identities = 111/351 (31%), Positives = 184/351 (52%), Gaps = 36/351 (10%)
Query: 831 ELRRGGMLGFGAFGKVY--KGVWVPEGENVK-IPVAIKVLKETTGANTSKEFLEEAYIMA 887
+L G LG G FG+V + + + + + + + VA+K+LK+ + + E +M
Sbjct: 476 KLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK 535
Query: 888 SV-EHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHK---------------EKIG 930
+ H N++ LL C + + +I + G L +Y+R + E +
Sbjct: 536 MIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEPLT 595
Query: 931 SKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY- 989
K ++ Q+ARGM YL ++ +HRDLAARNVLV N +KI DFGLA+ D++ +Y
Sbjct: 596 FKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLAR--DVHNIDYY 653
Query: 990 -KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE 1048
K G++P+KW+A E + R++TH+SDVW+FGV +WEI + G PY I + +L++
Sbjct: 654 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 713
Query: 1049 NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVI-PGDKFM 1107
G ++ +P+ CT ++Y +M CW + RPTFKQL + D R L + ++++
Sbjct: 714 EGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVE-------DLDRILTLATNEEYL 766
Query: 1108 RLPSYSTQDEKEMIRNLSSAMEGPESLVD----ADEYLQPKFKSMTGTVTT 1154
L + Q SS G +S+ ADE PK++ + G + T
Sbjct: 767 DLCAPVEQYSPSFPDTRSSCPSGDDSVFSHDPLADEPCLPKYQHINGGIKT 817
>UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein
kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor
tyrosine kinase MerTK).; n=1; Xenopus tropicalis|Rep:
Proto-oncogene tyrosine-protein kinase MER precursor (EC
2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK). -
Xenopus tropicalis
Length = 763
Score = 174 bits (424), Expect = 1e-41
Identities = 106/322 (32%), Positives = 167/322 (51%), Gaps = 27/322 (8%)
Query: 785 NFRQKAKAKKEAVKMTMVLTGCEDN--EPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGA 842
NF+ K + A+++T+ G + + L V+ NL L G +LG G
Sbjct: 432 NFKAKKSYNRRAIEITLSTLGINQDLQQKLEDVMVERNLLNL----------GKVLGEGE 481
Query: 843 FGKVYKG-VWVPEGENVKIPVAIKVLK-ETTGANTSKEFLEEAYIMASVEHPNLLQLLAV 900
FG V +G + +G N K VA+K +K + +EFL EA M HPN+++LL V
Sbjct: 482 FGSVMEGELQYSDGTNHK--VAVKTMKMDNFSQREIEEFLSEAACMKDFNHPNVIRLLGV 539
Query: 901 CMT------NQMMLITQLMPLGCLVDYVRTHK-----EKIGSKAFLNWCTQIARGMAYLE 949
C+ + M+I M G L ++ + + + + + + + IA GM YL
Sbjct: 540 CLEVGPRRIPKPMVILPFMKYGDLHSFLLSSRIGSGPQHVPLRTLVKFMIDIATGMEYLS 599
Query: 950 EKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHR 1009
+ +HRDLAARN +++ +V + DFGL+K + + + KMP+KW+A+E + R
Sbjct: 600 SRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAVESLADR 659
Query: 1010 IFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVS 1069
I+T KSDVWAFGVT+WEI + G PY + + + + G +L QP C D+Y VM
Sbjct: 660 IYTVKSDVWAFGVTMWEISTRGMTPYPGVQNHEIYDYLLVGHRLKQPPECLDDLYTVMYQ 719
Query: 1070 CWMLDADSRPTFKQLADTFAEM 1091
CW+ D RP+F L + ++
Sbjct: 720 CWLSDPTCRPSFTALRENLEKI 741
>UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta cDNA,
RIKEN full-length enriched library, clone:I530025O09
product:fibroblast growth factor receptor 1, full insert
sequence; n=18; Eumetazoa|Rep: 14 days pregnant adult
female placenta cDNA, RIKEN full-length enriched library,
clone:I530025O09 product:fibroblast growth factor
receptor 1, full insert sequence - Mus musculus (Mouse)
Length = 386
Score = 174 bits (424), Expect = 1e-41
Identities = 97/274 (35%), Positives = 150/274 (54%), Gaps = 24/274 (8%)
Query: 835 GGMLGFGAFGKVYKGVWV---PEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-E 890
G LG G FG+V + + N VA+K+LK + + E +M + +
Sbjct: 45 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 104
Query: 891 HPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHK---------------EKIGSKAF 934
H N++ LL C + + +I + G L +Y++ + E++ SK
Sbjct: 105 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 164
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY--KAA 992
++ Q+ARGM YL K+ +HRDLAARN LV N +KI DFGLA+ DI+ +Y K
Sbjct: 165 VSCAYQVARGMEYLASKKCIHRDLAARNALVTEDNVMKIADFGLAR--DIHHIDYYKKTT 222
Query: 993 GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLK 1052
G++P+KW+A E + RI+TH+SDVW+FGV +WEI + G PY + + +L++ G +
Sbjct: 223 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 282
Query: 1053 LPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
+ +PS CT ++Y +M CW RPTFKQL +
Sbjct: 283 MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE 316
>UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hydra
vulgaris|Rep: Tyrosine kinase receptor HTK32 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 752
Score = 174 bits (424), Expect = 1e-41
Identities = 98/301 (32%), Positives = 161/301 (53%), Gaps = 19/301 (6%)
Query: 837 MLGFGAFGKVYKGVWVPEGE-NVKIPVAIKVLKETTGANTSKEFLEEAYIMASVE-HPNL 894
+LG G +G V G + EG+ N+ V+IK+L + A T ++ L E +M V HPN+
Sbjct: 433 ILGSGEYGHVSGGRIIDEGDPNMCKDVSIKMLHDNASAETYRDMLNELRMMRRVSRHPNV 492
Query: 895 LQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHK---------------EKIGSKAFLNWC 938
+ L+ C+T+Q + ++ + P GCL+ ++RT + ++I K L++
Sbjct: 493 ISLIGWCITDQNLYVLEEYAPFGCLLTFLRTQRLLRLRQENLEELPSEDQIDEKTLLSFS 552
Query: 939 TQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPI 998
QIA GM +L ++VHRDLA RN+ + KI+++GL + + K GG++P+
Sbjct: 553 WQIASGMKHLAGLQIVHRDLACRNIYLGHEKVCKISEYGLTRDIYAENVYRKNTGGQLPV 612
Query: 999 KWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPY-ENISARNVPELIENGLKLPQPS 1057
+W+A E I ++T KSDVW+FG+ +WE++S G PY E I + +++E+G + P
Sbjct: 613 RWMAYEAIFESLYTEKSDVWSFGILLWELISLGKIPYPEIIRTEELLDVLESGYHMENPG 672
Query: 1058 ICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDE 1117
+ D Y +M SCW ++RP+F L AE D V F + QDE
Sbjct: 673 HISTDFYLLMNSCWNKAPENRPSFSSLVKKLAEFMNDKDEMHVNLNSFFKKELDNFLQDE 732
Query: 1118 K 1118
+
Sbjct: 733 E 733
>UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberites
domuncula|Rep: Receptor tyrosine kinase - Suberites
domuncula (Sponge)
Length = 715
Score = 174 bits (424), Expect = 1e-41
Identities = 97/257 (37%), Positives = 149/257 (57%), Gaps = 10/257 (3%)
Query: 838 LGFGAFGKVYKG-VWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-EHPNLL 895
LG GAFG V K ++ P + I VA+K+LKE+ K+ + E ++ V EH N++
Sbjct: 393 LGSGAFGVVKKAELFDPISQTTSI-VAVKMLKESASTEDEKDIIMELKVLYHVGEHCNVV 451
Query: 896 QLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLN----WCTQIARGMAYLEE 950
L + ++ LI + G L+ ++R+ + + S + +Q+A GMAYL
Sbjct: 452 SFLGASVHKGKLHLIVEYCERGNLLQFLRSKRGDMKSPLSVQNQVAIASQVANGMAYLAS 511
Query: 951 KRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRI 1010
KR +HRDLAARNVL+ ++K+ DFGLA+ + Y+ +G ++PIKW+A E I +
Sbjct: 512 KRCIHRDLAARNVLITKDLTLKVADFGLARKM--YSSVYRPSGKRLPIKWMAPEGILDGV 569
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
T KSDVW+FG+ +WEI++ G PY SA V IENG ++PQP C +Y VM C
Sbjct: 570 CTSKSDVWSFGILLWEIMTLGRTPYPGRSAHWVIRDIENGYRMPQPDGCPDKLYSVMKCC 629
Query: 1071 WMLDADSRPTFKQLADT 1087
W ++ +RP F +L ++
Sbjct: 630 WQMNPIARPEFTELTNS 646
>UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to Alk
CG8250-PA - Apis mellifera
Length = 1436
Score = 174 bits (423), Expect = 2e-41
Identities = 108/319 (33%), Positives = 167/319 (52%), Gaps = 17/319 (5%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG GAFG+V++GV+ N + PVA+K + ++ T +F+ EA IM+ HPN++
Sbjct: 894 LGQGAFGEVFQGVYRYR-RNQEQPVAVKAIPSSSRPQTEADFMMEALIMSKFNHPNIVHF 952
Query: 898 LAVCMT-NQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNW-----CT-QIARGMAYLEE 950
+ V N ++ +L+ G L +++R + + L C +A G Y+EE
Sbjct: 953 IGVSFERNPKYIVLELLAGGNLKNFLREERPRADRPTSLRMQDLIMCGFDVANGCKYMEE 1012
Query: 951 KRLVHRDLAARNVLVQTPNS---VKITDFGLAKLLDINEDEYKAAGGK--MPIKWLALEC 1005
R +HRD+AARN L+ + VKI DFG+AK DI +Y GGK +PIKW+ E
Sbjct: 1013 ARFIHRDIAARNCLLTSKGPGRIVKIADFGMAK--DIYRSDYYRKGGKAMLPIKWMPPES 1070
Query: 1006 IQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYC 1065
IFT K+DVWAFGV +WEI+S+G PY + R ++ G +L +P+ C IY
Sbjct: 1071 FLDGIFTTKTDVWAFGVLLWEIMSFGYIPYTGCTNREAMTMVTLGGRLEKPAGCPDPIYG 1130
Query: 1066 VMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLS 1125
+M CW + RP+F + + +DP + P F LP ++ M +
Sbjct: 1131 LMTRCWHPRPEDRPSFATIVERIGYCLQDPD-VINHPTPNFDILP-ICDREVTIMRPDPE 1188
Query: 1126 SAMEGPESLVDADEYLQPK 1144
+ +S +DA Y+QP+
Sbjct: 1189 TECINVQSELDACGYMQPR 1207
>UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein; n=1;
Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 522
Score = 173 bits (421), Expect = 3e-41
Identities = 86/282 (30%), Positives = 155/282 (54%), Gaps = 11/282 (3%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
++ + + G +L G FG+V++GV + + + V IK + + + ++E+ ++
Sbjct: 243 IERSRITLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTVTDHSSEEQRHLLVKESCLL 302
Query: 887 ASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHK-------EKIGSKAFLNWCT 939
+ H N+L LL VC ++ ++ M LG L +++ + + I ++ ++
Sbjct: 303 QGLSHKNILPLLHVCFSDPPFILEAFMKLGNLKQFLKNGRIGPGDKHQAISTRDLVHLAI 362
Query: 940 QIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGK--MP 997
QI GM YL +KRLVH+DLA RN ++ ++KITD L++ D+ +Y G P
Sbjct: 363 QITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSR--DLFPSDYHCLGDNENRP 420
Query: 998 IKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPS 1057
+KW+A+E + H+ F+H SDVW+FGVT+WE+++ G PY ++ + +++G ++PQP
Sbjct: 421 VKWMAVESLVHKKFSHASDVWSFGVTLWELVTLGQTPYMDLDPFEMATFLKSGYRMPQPP 480
Query: 1058 ICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYL 1099
C +++ +M CW L RP F QL + R G Y+
Sbjct: 481 SCPDELFNLMACCWALLPQDRPKFSQLCAALTDFHRTLGIYI 522
>UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2 -
Tribolium castaneum
Length = 473
Score = 173 bits (421), Expect = 3e-41
Identities = 94/243 (38%), Positives = 147/243 (60%), Gaps = 8/243 (3%)
Query: 850 VWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLI 909
+W + +N I VA+K+L+E G +++ FL+EA IM H L+ L VC ++ + I
Sbjct: 219 MWYGKWKN-NIEVAVKMLRE--GTMSTQAFLQEAAIMKKFRHKRLVTLFGVCSEHEPIYI 275
Query: 910 TQ-LMPLGCLVDYVRTHKEK-IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQT 967
Q M G L+D++R + K + + + Q+A GM YLE K+L+HRDLAARNVL+
Sbjct: 276 VQEYMSKGSLLDFLRKDEGKELEFEDLVYIAFQVASGMEYLESKQLIHRDLAARNVLIGE 335
Query: 968 PNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEI 1027
N KI DFGLA++++ NE K G + P+KW A E I + F+ KSDVW++G+ + E+
Sbjct: 336 NNIAKICDFGLARVIEDNEYCPK-QGSRFPVKWTAPEAIVYGKFSIKSDVWSYGIFLMEL 394
Query: 1028 LSYGARPYENISARNVPELIENGLKLPQPSICTL--DIYCVMVSCWMLDADSRPTFKQLA 1085
+YG PY + R V +++E G ++ +P+ L +IY +M+ CW ++RPTF+ L
Sbjct: 395 FTYGQVPYPGMHGREVIDMVEKGYRMGKPTSHVLPDEIYSIMLQCWDAKPENRPTFEFLT 454
Query: 1086 DTF 1088
F
Sbjct: 455 HYF 457
>UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase X - Ciona
intestinalis (Transparent sea squirt)
Length = 478
Score = 173 bits (421), Expect = 3e-41
Identities = 98/294 (33%), Positives = 158/294 (53%), Gaps = 13/294 (4%)
Query: 802 VLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPE------G 855
+++ +E L P ++ + L + + + ++G G FG VY G ++ G
Sbjct: 114 LISSASISEQLSPQILQEMSSVLISRNKLMVDKENIIGKGHFGTVYNGEYITSEISKLNG 173
Query: 856 ENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ--MMLITQLM 913
+K VAIK L + + ++FL+E +M+ N+L L+ + + M++ M
Sbjct: 174 NPIKRKVAIKTLSKIEDTESVEKFLKEGLMMSDFHDENVLTLIGISWDDDGAPMVVLPYM 233
Query: 914 PLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKI 973
G L+ ++R K + + Q +GM YL +R VHRDLAARN ++ VK+
Sbjct: 234 MHGDLLQFIRKPSNNPTVKDLVGFGLQACKGMCYLASQRFVHRDLAARNCMLNETYVVKV 293
Query: 974 TDFGLAKLLDINEDEYKAA---GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSY 1030
DFGLA+ DI E EY G+MP+KW+ALE +Q + FT K+DVW+FG+ +WE+L+
Sbjct: 294 ADFGLAR--DIYEKEYYKPHEHAGRMPVKWMALESLQQQTFTIKTDVWSFGILLWELLTR 351
Query: 1031 GARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
G PY ++ A +V I +G +L QP C +Y +M+SCW ++RP F L
Sbjct: 352 GVTPYPDVDAFDVVNYILDGRRLRQPQYCPDPLYELMLSCWHPLPETRPDFVTL 405
>UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1;
Crassostrea gigas|Rep: Tyrosine-protein kinase receptor -
Crassostrea gigas (Pacific oyster) (Crassostrea angulata)
Length = 804
Score = 173 bits (420), Expect = 4e-41
Identities = 117/356 (32%), Positives = 183/356 (51%), Gaps = 35/356 (9%)
Query: 755 PTATARTSTVLVIILVIASLFLAVL-AIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLR 813
PT TA +I + ++ + L +L +IG F +++ KK + D E
Sbjct: 266 PTTTAHWPPETIIAVTVSGVLLLILIVVIGVWFIARSRFKKIPDRPDFTSIN-PDYEHYN 324
Query: 814 PTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVP-EGENVKIPVAIKVLKETTG 872
P + K+++++E LG G+FG VY+GV G+ +I VA+K + E
Sbjct: 325 PDEWEVERDKIQLIRE--------LGQGSFGMVYEGVARDLYGKGGEIKVAVKTVNEHAT 376
Query: 873 ANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHK---EK 928
EFL EA M + ++++LL V Q +LI +LM G L +++R H+ E
Sbjct: 377 YRERMEFLSEASRMKAFSCNHVVRLLGVVSDGQPALLIMELMEKGDLKNFLRMHRPVEED 436
Query: 929 IGS----------------KAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVK 972
I S K + +IA GMAYL +K+ VHRDLAARN +V +VK
Sbjct: 437 IDSTFAGIKEHISRTPPTIKRIIQMAGEIADGMAYLADKKFVHRDLAARNCMVAEDLTVK 496
Query: 973 ITDFGLAKLLDINEDEYKAAGGK--MPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSY 1030
I DFG+ + DI E +Y GGK +P++W+A E ++ IFT SDVW++GV +WE+ +
Sbjct: 497 IADFGMTR--DIYETDYYRKGGKALLPVRWMAPESLKDGIFTSLSDVWSYGVVLWEMATL 554
Query: 1031 GARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
A+PY+ +S V + NG + +P C ++ +M CW RPTFK++ +
Sbjct: 555 AAQPYQGLSNEEVLRYVLNGRVMEKPEDCPDRLFELMQKCWRYRPKQRPTFKEILE 610
>UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 252
Score = 173 bits (420), Expect = 4e-41
Identities = 95/249 (38%), Positives = 138/249 (55%), Gaps = 16/249 (6%)
Query: 866 VLKETTGANTSKEFLEEAYIMASV-EHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVR 923
VL +T G +EFL+E +M + H N++ L + ML+ + +P G L+DY+R
Sbjct: 1 VLVDTAGPEQGEEFLKEISLMKKLGSHKNIVNFLCCSTVKEPFMLVVEFLPKGDLLDYLR 60
Query: 924 THKEK------------IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSV 971
++ K I + L++ QIA GM YL +K VHRDLAARNVLV V
Sbjct: 61 RNRSKQNDETGEQEDEMITPQDLLSFSYQIAAGMEYLSKKGFVHRDLAARNVLVADNKQV 120
Query: 972 KITDFGLAKLLDINEDEYKA-AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSY 1030
K+ DFGL + L E Y+ + K+PIKW++ E I +IFT +SDVW++GV +WEI +
Sbjct: 121 KVADFGLTRDL-YEESAYQGHSNRKLPIKWMSPEAIYDQIFTTESDVWSYGVVLWEIATL 179
Query: 1031 GARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
G PY IS R+V ++ +G ++ +P IC+ ++Y +M CW RPTF L F
Sbjct: 180 GGAPYPTISTRDVFVMLRSGYRMEKPDICSDEVYTIMKHCWEDQPKKRPTFSDLRMKFEY 239
Query: 1091 MARDPGRYL 1099
M YL
Sbjct: 240 MLEADNPYL 248
>UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 304
Score = 173 bits (420), Expect = 4e-41
Identities = 99/287 (34%), Positives = 154/287 (53%), Gaps = 31/287 (10%)
Query: 838 LGFGAFGKVYKG-VWVPEGENVKI----PVAIKVLKETTGANTSKEFLEEAYIMASV-EH 891
LG GAFG V K PE E K+ P A+K+LKE + ++ E IMA V +H
Sbjct: 13 LGSGAFGVVKKAKTEEPEEEKGKVLEIVPCAVKMLKENPTESELRDLCNEIAIMALVGDH 72
Query: 892 PNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHKE---------KIGS---------- 931
PN++ LL C N + L+ +L GC +DY++ H+ KI S
Sbjct: 73 PNIVSLLGACTVNGPLWLVVKLAENGCFLDYIKEHRSVVEYENTENKIHSYENVTEKTQG 132
Query: 932 -----KAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINE 986
K + +IA+GM +LE+K+ VHRDLAARN+L+ N ++DFGL++ + +
Sbjct: 133 APMTEKEKFKFAYEIAKGMRHLEKKKCVHRDLAARNILLNVDNVAMVSDFGLSRDVYESG 192
Query: 987 DEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPEL 1046
GG +P++W+A+E ++ +T KSDVW++GV +WE+ S G PY +S + E
Sbjct: 193 AYDNTTGGVLPVRWMAIESLEDYTYTTKSDVWSYGVLLWEMESGGLMPYAGMSGVEILER 252
Query: 1047 IENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMAR 1093
++ G +L +PS C+ ++Y +M CW + +RP F + E R
Sbjct: 253 LKQGYRLEKPSCCSQELYALMYECWNPEPKNRPAFSIIVSRLEETLR 299
>UniRef50_UPI0000E4A99A Cluster: PREDICTED: similar to tyrosine
kinase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to tyrosine kinase -
Strongylocentrotus purpuratus
Length = 685
Score = 172 bits (419), Expect = 5e-41
Identities = 95/248 (38%), Positives = 151/248 (60%), Gaps = 11/248 (4%)
Query: 797 VKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVP-EG 855
V++ VL E+++ L P + RI + +L++ LG G FG V++GV +P +G
Sbjct: 109 VEIESVLNPTEEDDILDPDEETKFIGVNRI-PDGQLKKEERLGSGHFGMVFRGVLMPRQG 167
Query: 856 ENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCM--TNQMMLITQLM 913
+I VA+KV+K + S +F +E M+ +H N++++L C +N++ L+ +
Sbjct: 168 IPAEI-VAVKVIKNDS---RSDQFQQEIRAMSYCDHKNIVKVLGYCEDNSNRLSLVMEYF 223
Query: 914 PLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRL-VHRDLAARNVLVQTPNSVK 972
PLG L Y+R K+++ K + QI +GM YL E+R+ VHRDLAARNVLV N VK
Sbjct: 224 PLGSLEKYLREKKDRVSHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENEVK 283
Query: 973 ITDFGLAKLLDINEDEYKA--AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSY 1030
ITDFGLA++ +D Y+A + K+PIKW A E ++H+ + +SDVW+ G+ +WE+ SY
Sbjct: 284 ITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLRHQKYQKESDVWSLGIVLWEMFSY 343
Query: 1031 GARPYENI 1038
G P + +
Sbjct: 344 GQDPIQTL 351
Score = 39.5 bits (88), Expect = 0.64
Identities = 23/92 (25%), Positives = 41/92 (44%), Gaps = 3/92 (3%)
Query: 1017 VWAFG-VTIWEILS--YGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWML 1073
VW G T+++++ Y + + + E G++L P C I +M CW +
Sbjct: 441 VWCDGRQTLYDVMGVCYQDSKGRRVEHIELLDFFEKGMRLTHPPSCPAAIETMMNDCWEM 500
Query: 1074 DADSRPTFKQLADTFAEMARDPGRYLVIPGDK 1105
D RP F+ + +A L++PGD+
Sbjct: 501 DPLKRPKFQSMIVRLGILADMIFSLLLLPGDE 532
>UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 442
Score = 172 bits (419), Expect = 5e-41
Identities = 107/309 (34%), Positives = 166/309 (53%), Gaps = 16/309 (5%)
Query: 815 TNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKG-VWVPEGENVKIPVAIKVLKETTGA 873
++++ +L L + EA + ++G G FG VY+G + P G IPVA+K LK
Sbjct: 120 SDLRQSLQGLLLPSEAVVLET-IVGKGYFGNVYRGRMRDPAGR--LIPVAVKTLKGERAR 176
Query: 874 NTS--KEFLEEAYIMASVEHPNLLQLLAVCMT--NQMMLITQLMPLGCLVDYVRTHKEKI 929
+ + ++FL E +M ++HP++L LL + ++ ++ M G L Y+ +
Sbjct: 177 DIAHIEKFLREGVVMKHLDHPHVLSLLGISISPAGNPWVVLPYMEGGDLKTYIADPNRAL 236
Query: 930 GSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLA-KLLDINE-- 986
L++ Q+A+GM+YL + VHRDLAARN ++ VK+ DFGLA LLD
Sbjct: 237 CVLELLDFAHQVAQGMSYLAAQHFVHRDLAARNCMISADRIVKVADFGLAVDLLDKESYI 296
Query: 987 DEYKAAGGKMPIKWLALECIQ-HRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPE 1045
DE + ++P+KWLA E ++ R+F+ +DVW+FGV +WE+L+ A PY +S V
Sbjct: 297 DESETGPARLPLKWLAPESLRDRRVFSSATDVWSFGVLMWELLTRAASPYGEVSNTKVRH 356
Query: 1046 LIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTF----KQLADTFAEMARDPGRYLVI 1101
+E G++LPQP+ C IY +M CW + RP F +L E DP V
Sbjct: 357 YLETGMRLPQPTHCPDIIYDLMQCCWRSTPEDRPDFVFLSHRLRALLQENTPDPFTRRVR 416
Query: 1102 PGDKFMRLP 1110
PG + LP
Sbjct: 417 PGAEQFLLP 425
>UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase Yes;
n=422; root|Rep: Proto-oncogene tyrosine-protein kinase
Yes - Homo sapiens (Human)
Length = 543
Score = 172 bits (419), Expect = 5e-41
Identities = 101/260 (38%), Positives = 140/260 (53%), Gaps = 11/260 (4%)
Query: 827 VKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIM 886
+ LR LG G FG+V+ G W N VAIK LK G + FL+EA IM
Sbjct: 272 IPRESLRLEVKLGQGCFGEVWMGTW-----NGTTKVAIKTLKP--GTMMPEAFLQEAQIM 324
Query: 887 ASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEK-IGSKAFLNWCTQIARGM 945
+ H L+ L AV + ++T+ M G L+D+++ K + ++ QIA GM
Sbjct: 325 KKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGM 384
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAA-GGKMPIKWLALE 1004
AY+E +HRDL A N+LV KI DFGLA+L++ NE Y A G K PIKW A E
Sbjct: 385 AYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNE--YTARQGAKFPIKWTAPE 442
Query: 1005 CIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIY 1064
+ FT KSDVW+FG+ E+++ G PY + R V E +E G ++P P C ++
Sbjct: 443 AALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLH 502
Query: 1065 CVMVSCWMLDADSRPTFKQL 1084
+M CW D D RPTF+ +
Sbjct: 503 ELMNLCWKKDPDERPTFEYI 522
>UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror precursor; n=1; Drosophila melanogaster|Rep:
Tyrosine-protein kinase transmembrane receptor Ror
precursor - Drosophila melanogaster (Fruit fly)
Length = 685
Score = 172 bits (419), Expect = 5e-41
Identities = 96/256 (37%), Positives = 141/256 (55%), Gaps = 10/256 (3%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG GAFGKVYKG + + I VAIK LKE T ++F E +++ ++H N++ +
Sbjct: 416 LGEGAFGKVYKGQLLQPNKTT-ITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCI 474
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYV----RTHKEKIGSKAFLNWCTQIARGMAYLEEKR 952
L V + + ++ + M G L +++ T + + FL QI+ GM YL
Sbjct: 475 LGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQISEGMQYLSAHH 534
Query: 953 LVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGK--MPIKWLALECIQHRI 1010
VHRDLAARN LV VKI+DFGL++ DI +Y K +P++W+ E I +
Sbjct: 535 YVHRDLAARNCLVNEGLVVKISDFGLSR--DIYSSDYYRVQSKSLLPVRWMPSESILYGK 592
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
FT +SDVW+FGV +WEI SYG +PY S + V LI + L P C +Y +M+ C
Sbjct: 593 FTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIEC 652
Query: 1071 WMLDADSRPTFKQLAD 1086
W + RPTF +++
Sbjct: 653 WHEQSVKRPTFTDISN 668
>UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1;
Geodia cydonium|Rep: Tyrosine-protein kinase receptor -
Geodia cydonium (Sponge)
Length = 570
Score = 172 bits (418), Expect = 7e-41
Identities = 114/357 (31%), Positives = 179/357 (50%), Gaps = 37/357 (10%)
Query: 762 STVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMT--------MVLTGCEDN--EP 811
+TVL++I+VI + ++ + R+K E + T M G N EP
Sbjct: 183 ATVLLLIVVIVVVIATIIVLKEQAVRKKMNYSLENARQTPSVPDYIEMYTQGQASNYLEP 242
Query: 812 LRPTNVKPNLAKLR------IVKEAELRRGGMLGFGAFGKVYKG-VWVPEGENVKIPVAI 864
+ +K R ++ E +L LG GAFG+VYKG + + ++ + VAI
Sbjct: 243 VSSRAQVDMYSKWRGPLKGLLLAEDQLILTESLGEGAFGRVYKGSMKTGDDDDRTVEVAI 302
Query: 865 KVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTN---QMMLITQLMPLGCLVDY 921
K LK+ + F++E+ +M HPN+L+LL VC +++ M G L Y
Sbjct: 303 KTLKDISQQENIDNFVQESILMLGFNHPNVLELLGVCFDTTDRHPLIVLPFMANGDLRSY 362
Query: 922 VRTHKEKIGSKAFLNW------------CTQIARGMAYLEEKRLVHRDLAARNVLVQTPN 969
+ + ++ + F ++ C ++ARGM YL VHRDLAARN +V
Sbjct: 363 LMSKRDPSVTTKFTHFPQGLDEERALVMCLEVARGMEYLSNSSFVHRDLAARNCMVSGEL 422
Query: 970 SVKITDFGLAKLLDINEDEYKAAGGK--MPIKWLALECIQHRIFTHKSDVWAFGVTIWEI 1027
+V++ DFGL++ D+ +Y G K +P+KW+A E + IFT KSDVW+FGV WE+
Sbjct: 423 TVRVADFGLSR--DVYSKDYYRMGTKTMLPVKWMAPESLADNIFTVKSDVWSFGVVCWEV 480
Query: 1028 LSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
S A PY I + + I G +L P +C +IY +M CW +++ RP F +L
Sbjct: 481 FSLVA-PYPGIGNHEMSDYIGGGRRLKIPRLCPREIYELMEQCWNEESNKRPNFSEL 536
>UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1
precursor; n=33; Euteleostomi|Rep: Fibroblast growth
factor receptor 1 precursor - Xenopus laevis (African
clawed frog)
Length = 812
Score = 172 bits (418), Expect = 7e-41
Identities = 96/274 (35%), Positives = 148/274 (54%), Gaps = 24/274 (8%)
Query: 835 GGMLGFGAFGKVYKGVWV---PEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-E 890
G LG G FG+V + E N VA+K+LK + + E +M + +
Sbjct: 475 GKPLGEGCFGQVVMAEAIGLDKEKPNKVTKVAVKMLKSDASEKDLSDLISEMEMMKMIGK 534
Query: 891 HPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHK---------------EKIGSKAF 934
H N++ LL C + + +I + G L +Y+R + + + K
Sbjct: 535 HKNIINLLGACTQDGPLYVIVEYTSKGNLREYLRARRPPAMEYCYNPTCVPDQLLSFKDL 594
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY--KAA 992
++ Q+ARGM YL K+ +HRDLAARNVLV N +KI DFGLA+ DI+ +Y K
Sbjct: 595 VSCAYQVARGMDYLASKKCIHRDLAARNVLVTEDNIMKIADFGLAR--DIHHIDYYKKTT 652
Query: 993 GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLK 1052
G++P+KW+A E + RI+TH+SDVW+FGV +WEI + G PY + + +L++ G +
Sbjct: 653 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPMEELFKLLKEGHR 712
Query: 1053 LPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
+ +P+ CT ++Y +M CW RPTF QL +
Sbjct: 713 MDKPTNCTNELYMMMKDCWHAMPSQRPTFNQLVE 746
>UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3;
Endopterygota|Rep: Tyrosine-protein kinase receptor -
Anopheles gambiae str. PEST
Length = 646
Score = 171 bits (417), Expect = 9e-41
Identities = 97/254 (38%), Positives = 141/254 (55%), Gaps = 10/254 (3%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQL 897
LG GAFGKVYKG + + +I VA+K LKE A T +F E +++ ++H N++ +
Sbjct: 380 LGEGAFGKVYKGE-LTQKNGERIFVAVKALKENASAKTQADFKREIELISDLKHDNIVCI 438
Query: 898 LAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKA----FLNWCTQIARGMAYLEEKR 952
L V + + + ++ + M G L +++ + G FL QI GM YL
Sbjct: 439 LGVVLKEEPLCMLFEYMAQGDLHEFLIANSPNEGKSLSQLQFLLIAQQICDGMEYLASHH 498
Query: 953 LVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGK--MPIKWLALECIQHRI 1010
VHRDLAARN LV +VKI+DFGL++ DI +Y K +P++W+ E I +
Sbjct: 499 YVHRDLAARNCLVGDNLTVKISDFGLSR--DIYSSDYYRVQSKSLLPVRWMPSESILYGK 556
Query: 1011 FTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSC 1070
FT +SDVW+FGV +WEI SYG +PY S + V ++ LP P C +Y +MV C
Sbjct: 557 FTTESDVWSFGVVLWEIYSYGLQPYYGYSNQEVINMVRARQLLPCPESCPSAVYSLMVEC 616
Query: 1071 WMLDADSRPTFKQL 1084
W A RPTF ++
Sbjct: 617 WHEQAVRRPTFPEI 630
>UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 315
Score = 171 bits (417), Expect = 9e-41
Identities = 94/280 (33%), Positives = 157/280 (56%), Gaps = 25/280 (8%)
Query: 838 LGFGAFGKVYKGVWVP-EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVE-HPNLL 895
LG G FG V K + + G ++ VA+K LK T +FL E +M S+ HP+++
Sbjct: 34 LGSGNFGHVDKAMAIGIPGFPGQVTVAVKTLKATAQEKDKTDFLTELNLMKSLRPHPHVV 93
Query: 896 QLLAVC------MTNQMMLITQLMPLGCLVDYVRT---HKE-----------KIGSKAFL 935
+L+ C ++N + +I + +P G L+ Y+R H++ ++ SK +
Sbjct: 94 RLIGCCTRQAGELSNHLAIIFEYLPYGDLLGYLRRSRGHEDWYCSGDLRPPSRLVSKDLV 153
Query: 936 NWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGG 994
+ IA GMA+L + VHRDLAARNVLV N+ KI+D GLA+ D+++D Y + +
Sbjct: 154 KFAWMIADGMAFLAANKCVHRDLAARNVLVGEHNTCKISDLGLAR--DVSQDIYTRTSSA 211
Query: 995 KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLP 1054
++P+KW+ E + + + SDVW++G+ +WEI + G PY + ++ +P ++ G ++P
Sbjct: 212 RLPVKWMPPESLLYGQSSSASDVWSYGIVLWEIFTIGDSPYPGVKSKGIPRMLREGYRMP 271
Query: 1055 QPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
+P +Y VM+ CW D D RPTF +L D + +D
Sbjct: 272 KPPHVGDALYFVMLRCWQEDPDERPTFDELCDNMQALQQD 311
>UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase LCK;
n=11; Coelomata|Rep: Proto-oncogene tyrosine-protein
kinase LCK - Homo sapiens (Human)
Length = 516
Score = 171 bits (417), Expect = 9e-41
Identities = 92/225 (40%), Positives = 135/225 (60%), Gaps = 6/225 (2%)
Query: 862 VAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDY 921
VA+K LK+ G+ + FL EA +M ++H L++L AV + +IT+ M G LVD+
Sbjct: 277 VAVKSLKQ--GSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDF 334
Query: 922 VRTHKE-KIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAK 980
++T K+ L+ QIA GMA++EE+ +HRDL A N+LV S KI DFGLA+
Sbjct: 335 LKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLAR 394
Query: 981 LLDINEDEYKAA-GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENIS 1039
L++ NE Y A G K PIKW A E I + FT KSDVW+FG+ + EI+++G PY ++
Sbjct: 395 LIEDNE--YTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMT 452
Query: 1040 ARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
V + +E G ++ +P C ++Y +M CW + RPTF L
Sbjct: 453 NPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYL 497
>UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homolog 2
precursor; n=4; Coelomata|Rep: Fibroblast growth factor
receptor homolog 2 precursor - Drosophila melanogaster
(Fruit fly)
Length = 1052
Score = 171 bits (417), Expect = 9e-41
Identities = 101/292 (34%), Positives = 162/292 (55%), Gaps = 32/292 (10%)
Query: 827 VKEAELRRGGMLGFGAFGKVY--KGVWVPEGENV-KIPVAIKVLKETTGANTSKEFLEEA 883
+ +L G +LG GAFG+V + +P + + VA+K++KE + E
Sbjct: 707 IPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREM 766
Query: 884 YIMASV-EHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHK--------------- 926
+M + +H N++ LL C + +I + P G L D+++ ++
Sbjct: 767 EVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLD 826
Query: 927 -------EKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLA 979
+ +G K + QIARGM YL +R +HRDLAARNVLV +KI DFGLA
Sbjct: 827 DKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLA 886
Query: 980 KLLDINEDEY--KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYEN 1037
+ DI + EY K G++PIKW+A E +Q + + +SDVW++GV +WEI++YG +PY +
Sbjct: 887 R--DIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPH 944
Query: 1038 I-SARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTF 1088
I SA + + G ++ +P+ C+L+IY VM CW ++ +RPTF +L ++F
Sbjct: 945 ILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESF 996
>UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;
Obtectomera|Rep: Fibroblast growth factor receptor -
Bombyx mori (Silk moth)
Length = 856
Score = 171 bits (416), Expect = 1e-40
Identities = 98/281 (34%), Positives = 154/281 (54%), Gaps = 24/281 (8%)
Query: 827 VKEAELRRGGMLGFGAFGKVYK----GVWVPEGENVKIPVAIKVLKETTGANTSKEFLEE 882
V L G +LG G FGKV K G+ P ++V VA+K+LKE + E
Sbjct: 535 VPRESLSLGKVLGEGEFGKVVKAECIGILKPGLQSV---VAVKMLKEGHTDAEMMALVSE 591
Query: 883 AYIMASV-EHPNLLQLLAVC-MTNQMMLITQLMPLGCLVDYVRTH-------------KE 927
+M + +H N++ LL C + +I + P G L +++R H KE
Sbjct: 592 MEMMKMIGKHVNIINLLGCCTQDGPLYVIVEYAPNGNLREFLRNHRPGNRYESPNEDLKE 651
Query: 928 K--IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDIN 985
K + K +++ Q+ARGM YL +R +HRD AARNVLV +KI DFGLAK + N
Sbjct: 652 KKTLTQKDLVSFSYQVARGMEYLASRRCIHRDSAARNVLVSDDCVLKIADFGLAKDVHSN 711
Query: 986 EDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPE 1045
+ K G++P++W+A E + H++FT ++DVW+FGV +WEI++ G PY + + + +
Sbjct: 712 DYYRKKTEGRLPVRWMAPESLYHKVFTTQTDVWSFGVLLWEIMTLGGTPYPTVPGQYMYQ 771
Query: 1046 LIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
+ G ++ +P C+L+IY +M CW RP+F +L +
Sbjct: 772 HLSAGHRMEKPPCCSLEIYMLMRECWSFSPGDRPSFTELVE 812
>UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1
precursor; n=37; Deuterostomia|Rep: Tyrosine-protein
kinase receptor Tie-1 precursor - Homo sapiens (Human)
Length = 1138
Score = 171 bits (415), Expect = 2e-40
Identities = 107/369 (28%), Positives = 184/369 (49%), Gaps = 26/369 (7%)
Query: 737 QLQDPIEEPYCSEHANDIPTATARTSTVLVIILVIASLFLAVLAIIG--YNFRQKAKAKK 794
Q + P++E +E D A +V L I + L ++ I + R+ +
Sbjct: 742 QAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQS 801
Query: 795 EAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPE 854
+ + T++ R ++P +++ ++ ++G G FG+V + + +
Sbjct: 802 GSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKD 861
Query: 855 GENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-EHPNLLQLLAVCMTNQMMLIT-QL 912
G +K+ AIK+LKE N ++F E ++ + HPN++ LL C + I +
Sbjct: 862 G--LKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEY 919
Query: 913 MPLGCLVDYVRTHK---------------EKIGSKAFLNWCTQIARGMAYLEEKRLVHRD 957
P G L+D++R + + S+ L + + A GM YL EK+ +HRD
Sbjct: 920 APYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRD 979
Query: 958 LAARNVLVQTPNSVKITDFGLAKLLDINEDEY-KAAGGKMPIKWLALECIQHRIFTHKSD 1016
LAARNVLV + KI DFGL++ E+ Y K G++P++W+A+E + + ++T KSD
Sbjct: 980 LAARNVLVGENLASKIADFGLSR----GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSD 1035
Query: 1017 VWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDAD 1076
VW+FGV +WEI+S G PY ++ + E + G ++ QP C ++Y +M CW
Sbjct: 1036 VWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPY 1095
Query: 1077 SRPTFKQLA 1085
RP F Q+A
Sbjct: 1096 ERPPFAQIA 1104
>UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase; n=6;
Bilateria|Rep: Developmental receptor tyrosine kinase -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 874
Score = 170 bits (414), Expect = 2e-40
Identities = 101/280 (36%), Positives = 153/280 (54%), Gaps = 16/280 (5%)
Query: 822 AKLR--IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTS-KE 878
AKL+ ++ E L G MLG G FG V + ++ N VA+KVLK +++ ++
Sbjct: 485 AKLQDVLIFERLLTLGRMLGKGEFGSV-REAFLKSENNSGQKVAVKVLKTDINSSSDIEQ 543
Query: 879 FLEEAYIMASVEHPNLLQLLAVCMTNQM-------MLITQLMPLGCLVDYV---RTHKEK 928
L+EA M HPN++QL+ V + + M+I M G L ++ R E
Sbjct: 544 CLKEAAYMKDFHHPNVIQLIGVSLHRRAQQRLPIPMVILPFMKHGDLHTFLLMSRLGDEP 603
Query: 929 --IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINE 986
+ + + + IARGM YL K ++HRDLAARN ++ SV + DFGL+K + +
Sbjct: 604 FTVSQQILIQFMLDIARGMEYLSNKNIIHRDLAARNCMLNENMSVCVADFGLSKKIYSGD 663
Query: 987 DEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPEL 1046
+ + K+P+KW+ALE + ++T +SDVWAFGVT+WEI++ G PY + + E
Sbjct: 664 YYRQGSVSKLPVKWIALESLADNVYTTQSDVWAFGVTMWEIMTRGQTPYPGVENSEIYEY 723
Query: 1047 IENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
+ G +L QP C DIY +M SCW RP+F+ L D
Sbjct: 724 LIKGERLKQPPDCPADIYEIMHSCWSPVPKCRPSFQHLID 763
>UniRef50_Q13470 Cluster: Non-receptor tyrosine-protein kinase TNK1;
n=22; Eutheria|Rep: Non-receptor tyrosine-protein kinase
TNK1 - Homo sapiens (Human)
Length = 666
Score = 170 bits (413), Expect = 3e-40
Identities = 92/272 (33%), Positives = 149/272 (54%), Gaps = 9/272 (3%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVW-VPEGENVKIPVAIKVLK---ETTGANTSKEFLE 881
++ E + RG +LG G FG V++G+W +P G++V PVA+K L+ E +FL
Sbjct: 110 LIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSV--PVAVKSLRVGPEGPMGTELGDFLR 167
Query: 882 EAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLN--WCT 939
E +M ++EHP++L+L + + + ++ +L PLG L + L +
Sbjct: 168 EVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLR 227
Query: 940 QIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGK-MPI 998
Q+A MAYL + LVHRDLA RN+L+ +P ++K+ DFGL + L Y G + +P
Sbjct: 228 QLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPY 287
Query: 999 KWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSI 1058
W A E ++H F+ SDVW FGVT+WE+ S G P+ + + + +E+ +LP+P +
Sbjct: 288 AWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPL 347
Query: 1059 CTLDIYCVMVSCWMLDADSRPTFKQLADTFAE 1090
C+ +Y + + CW RP+F L E
Sbjct: 348 CSRALYSLALRCWAPHPADRPSFSHLEGLLQE 379
>UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homolog 1
precursor; n=3; Sophophora|Rep: Fibroblast growth factor
receptor homolog 1 precursor - Drosophila melanogaster
(Fruit fly)
Length = 729
Score = 170 bits (413), Expect = 3e-40
Identities = 105/309 (33%), Positives = 164/309 (53%), Gaps = 32/309 (10%)
Query: 835 GGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-EHPN 893
G LG GAFG+V + E N VA+K++KE + + E +M + H N
Sbjct: 419 GATLGEGAFGRVV----MAEVNNAI--VAVKMVKEGHTDDDIASLVREMEVMKIIGRHIN 472
Query: 894 LLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHK-------------------EKIGSKA 933
++ LL C N + +I + P G L D++ ++ I K
Sbjct: 473 IINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKD 532
Query: 934 FLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY--KA 991
+ + QIARGM YL +R +HRDLAARNVLV +KI DFGLA+ DI +Y K
Sbjct: 533 LIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLAR--DIQSTDYYRKN 590
Query: 992 AGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENI-SARNVPELIENG 1050
G++PIKW+A E +Q + + KSDVW++G+ +WEI++YG +PY I SA + + +G
Sbjct: 591 TNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSG 650
Query: 1051 LKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLP 1110
++ +P+ C+++IY +M CW +AD RP F ++ + ++ + YL + P
Sbjct: 651 QRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPP 710
Query: 1111 SYSTQDEKE 1119
S S ++E E
Sbjct: 711 STSDEEEDE 719
>UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:
Protein sevenless - Drosophila melanogaster (Fruit fly)
Length = 2554
Score = 170 bits (413), Expect = 3e-40
Identities = 105/306 (34%), Positives = 163/306 (53%), Gaps = 24/306 (7%)
Query: 809 NEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLK 868
N T ++A L + ++L+ LG GAFG+VY+G E VAIK L+
Sbjct: 2186 NRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLR 2245
Query: 869 ETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCM-TNQMMLITQLMPLGCLVDYVRTHKE 927
+ GA+ E L+EA +M++ +H N++ L+ +C T + LI + M G L+ Y+R +
Sbjct: 2246 K--GASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARA 2303
Query: 928 K----------IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPN-------S 970
+ L C +A G +YLE+ VHRDLA RN LV +
Sbjct: 2304 TSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRT 2363
Query: 971 VKITDFGLAKLLDINEDEY--KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEIL 1028
VKI DFGLA+ DI + +Y K G +P++W++ E + +FT +SDVWAFGV WEIL
Sbjct: 2364 VKIGDFGLAR--DIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEIL 2421
Query: 1029 SYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTF 1088
+ G +PY + V ++ G +L QP +CT +Y +++ CW D RP+F++ +T
Sbjct: 2422 TLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTL 2481
Query: 1089 AEMARD 1094
++ D
Sbjct: 2482 HAISTD 2487
>UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n=3;
Danio rerio|Rep: UPI00015A7C25 UniRef100 entry - Danio
rerio
Length = 759
Score = 169 bits (412), Expect = 4e-40
Identities = 93/269 (34%), Positives = 152/269 (56%), Gaps = 16/269 (5%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFL-EEAY 884
+++ ++ G +G G FG+V+ G +N PVA+K +E A +FL E A
Sbjct: 485 VLEHDDVILGQSIGRGNFGEVFSGRL--RSDNT--PVAVKACRENLPAEHKNKFLMEAAR 540
Query: 885 IMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIAR 943
I+ +HPN+++L+ VC Q + +I +L+ G + ++RT + S + +A
Sbjct: 541 ILKQYDHPNIVKLIGVCTQKQPIYIIMELVQGGDFLTFLRTEGHNLKSSMLIRMAENVAS 600
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG--KMPIKWL 1001
G+AYLE K+ +HRD+AARN LV + VKI+DFG+++ + + Y A GG ++P+KW
Sbjct: 601 GLAYLESKKCIHRDVAARNCLVGEESVVKISDFGMSR--EEQDGVYSATGGMKQIPVKWT 658
Query: 1002 ALECIQHRI---FTHKSDVWAFGVTIWEILSYGARPY---ENISARNVPELIENGLKLPQ 1055
A E + + +T +SDVW+FGV +WE S G PY +S + + +E G ++P
Sbjct: 659 APEALNYGSPGRYTTESDVWSFGVLLWETFSRGVTPYTIPTVMSNQQTRDEVERGYRMPA 718
Query: 1056 PSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
P+ C +IY +M CW D RP+F +L
Sbjct: 719 PNNCPDEIYTLMCQCWQYDPRKRPSFLKL 747
>UniRef50_UPI000065E56D Cluster: EPHB1_HUMAN Isoform 3 of P54762 -
Homo sapiens (Human); n=1; Takifugu rubripes|Rep:
EPHB1_HUMAN Isoform 3 of P54762 - Homo sapiens (Human) -
Takifugu rubripes
Length = 983
Score = 169 bits (412), Expect = 4e-40
Identities = 103/283 (36%), Positives = 156/283 (55%), Gaps = 34/283 (12%)
Query: 819 PNLAKLRIVKEAEL---RRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANT 875
PN A KE ++ + ++G G FG+VYKG G+ ++ VAIK LK
Sbjct: 630 PNEAVREFAKEIDVSTVKIEEVIGAGEFGEVYKGRLKLPGKR-ELYVAIKTLKSGYVEKQ 688
Query: 876 SKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFL 935
++FL EA IM +HPN+++L V +T+ PL V +R
Sbjct: 689 RRDFLSEASIMGQFDHPNIIRLEGV--------VTKSRPL---VGMMRG----------- 726
Query: 936 NWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLL--DINEDEYKAA- 992
I+ GM YL E VHRDLAARN+LV + K++DFGL++ L D ++ Y ++
Sbjct: 727 -----ISAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQEDTSDPSYTSSL 781
Query: 993 GGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLK 1052
GGK+P++W A E I +R FT SDVW++G+ +WE++S+G RPY ++S ++V IE +
Sbjct: 782 GGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYR 841
Query: 1053 LPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
LP P C ++ +M+ CW D + RP F + T +M R+P
Sbjct: 842 LPPPMDCPSTLHQLMLDCWQKDRNVRPRFADIVSTLDKMIRNP 884
>UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 624
Score = 169 bits (412), Expect = 4e-40
Identities = 96/273 (35%), Positives = 150/273 (54%), Gaps = 19/273 (6%)
Query: 838 LGFGAFGKVYKGVWVPEGEN-VKIPVAIKVLKETTGANTSKEFLEEAYIMASV-EHPNLL 895
LG GAFG V K + + + VA+K+LK N + L E M ++ H N++
Sbjct: 340 LGEGAFGLVMKAEALGLTDMPYRHTVAVKMLKADATENELADLLSEMDTMKNIGSHKNII 399
Query: 896 QLLAVCMTN-QMMLITQLMPLGCLVDYVRT------HKEKIGSKA----------FLNWC 938
L+ C N + ++ + P G L ++R H+ + S F+++
Sbjct: 400 NLIGACTQNGPLYVVVEFAPHGNLRQFLRERRPSDYHRSRSDSSTHSQPSLIVRDFISFA 459
Query: 939 TQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPI 998
QIARGM YL K+ +HRDLAARN+LV +KI DFGLA+ + + KA G++PI
Sbjct: 460 FQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLARNVRDMDYYRKATDGRLPI 519
Query: 999 KWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSI 1058
KWLA+E + R++T +SDVW FG+ +WEI + G PY I + EL+++G ++ P
Sbjct: 520 KWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGIPVEKLFELLKSGYRMQMPQK 579
Query: 1059 CTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
C +Y +M+SCW + ++RP+F +L F +M
Sbjct: 580 CPDKMYDIMLSCWNENPNARPSFTELRAEFDKM 612
>UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor a - Nematostella vectensis
Length = 441
Score = 169 bits (412), Expect = 4e-40
Identities = 96/273 (35%), Positives = 150/273 (54%), Gaps = 19/273 (6%)
Query: 838 LGFGAFGKVYKGVWVPEGEN-VKIPVAIKVLKETTGANTSKEFLEEAYIMASV-EHPNLL 895
LG GAFG V K + + + VA+K+LK N + L E M ++ H N++
Sbjct: 125 LGEGAFGLVMKAEALGLTDMPYRHTVAVKMLKADATENELADLLSEMDTMKNIGSHKNII 184
Query: 896 QLLAVCMTN-QMMLITQLMPLGCLVDYVRT------HKEKIGSKA----------FLNWC 938
L+ C N + ++ + P G L ++R H+ + S F+++
Sbjct: 185 NLIGACTQNGPLYVVVEFAPHGNLRQFLRERRPSDYHRSRSDSSTHSQPSLIVRDFISFA 244
Query: 939 TQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPI 998
QIARGM YL K+ +HRDLAARN+LV +KI DFGLA+ + + KA G++PI
Sbjct: 245 FQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLARNVRDMDYYRKATDGRLPI 304
Query: 999 KWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSI 1058
KWLA+E + R++T +SDVW FG+ +WEI + G PY I + EL+++G ++ P
Sbjct: 305 KWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGIPVEKLFELLKSGYRMQMPQK 364
Query: 1059 CTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
C +Y +M+SCW + ++RP+F +L F +M
Sbjct: 365 CPDKMYDIMLSCWNENPNARPSFTELRAEFDKM 397
>UniRef50_Q01974 Cluster: Tyrosine-protein kinase transmembrane
receptor ROR2 precursor; n=36; Euteleostomi|Rep:
Tyrosine-protein kinase transmembrane receptor ROR2
precursor - Homo sapiens (Human)
Length = 943
Score = 169 bits (412), Expect = 4e-40
Identities = 115/355 (32%), Positives = 177/355 (49%), Gaps = 25/355 (7%)
Query: 753 DIPTATARTSTVLVIILVIAS-----LFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCE 807
D+P+ + R S+ + I+ ++ L +A L + R K KA + ++
Sbjct: 390 DVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPS 449
Query: 808 DNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKG-VWVPEGENVKIPVAIKV 866
+ + N + AKL+ + + +R LG FGKVYKG ++ P VAIK
Sbjct: 450 QDMEMPLIN-QHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKT 508
Query: 867 LKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ-MMLITQLMPLGCLVDYV--- 922
LK+ +EF EA + A ++HPN++ LL V +Q + +I G L +++
Sbjct: 509 LKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMR 568
Query: 923 ------------RTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNS 970
RT K + F++ QIA GM YL +VH+DLA RNVLV +
Sbjct: 569 SPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLN 628
Query: 971 VKITDFGLAKLLDINEDEYKAAGGKM-PIKWLALECIQHRIFTHKSDVWAFGVTIWEILS 1029
VKI+D GL + + D YK G + PI+W+A E I + F+ SD+W++GV +WE+ S
Sbjct: 629 VKISDLGLFREV-YAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFS 687
Query: 1030 YGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
YG +PY S ++V E+I N LP P C +Y +M+ CW RP FK +
Sbjct: 688 YGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 742
>UniRef50_Q25198 Cluster: Receptor tyrosine kinase 90; n=1; Hydra
vulgaris|Rep: Receptor tyrosine kinase 90 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 848
Score = 169 bits (411), Expect = 5e-40
Identities = 94/258 (36%), Positives = 143/258 (55%), Gaps = 5/258 (1%)
Query: 837 MLGFGAFGKVYKGV--WVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNL 894
+LG+G FGKV+K + E E VA+KV +ET N F +E + ++ +
Sbjct: 593 VLGYGKFGKVFKAYAKGICE-EGTDTLVAVKVFEETPVNNVLSAFNKETEDLMQFQNSYV 651
Query: 895 LQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLV 954
++LL + + +IT+ LG L +Y++T+K S A L+ CT IA+GM+YL V
Sbjct: 652 VRLLGLVRESPFCIITEYSELGDLKEYLQTNKNT-SSSARLHMCTCIAKGMSYLATLHYV 710
Query: 955 HRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHK 1014
HRDLAARN ++ + N VK++ L +D Y P++WLA E I+ I+ K
Sbjct: 711 HRDLAARNCILFSQNEVKVSFLSLCNTT-YKDDYYLLNNLLAPVRWLAPESIRENIYNEK 769
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
+DVW+F VT+WEI S +P+ +S V I L+L PS C +Y +M CW+++
Sbjct: 770 TDVWSFSVTMWEIFSSEVQPFYGVSNEEVVNRIGKDLQLTIPSNCPKTLYKIMTRCWLVN 829
Query: 1075 ADSRPTFKQLADTFAEMA 1092
A RPTF +L AE++
Sbjct: 830 AFDRPTFDELLSLMAEIS 847
>UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 865
Score = 168 bits (409), Expect = 8e-40
Identities = 141/484 (29%), Positives = 217/484 (44%), Gaps = 41/484 (8%)
Query: 645 HEQVCQVCNGFKRGDQCEDE-CPSDHFTDEIGRNCTPCHSECKGCTGPGPTDCIKCK-NL 702
H ++ C+ +G C P D+ T + C C+ TD CK +L
Sbjct: 390 HSEITSDCSQLLKGILCAVAYAPCDNTT---AQPLEMCSESCQLLRSI--TDGRLCKEDL 444
Query: 703 KIFLGGSDASDE-NAPF---NCTDTCPDNIPNKIYFDEQLQDPIEEPYCSEHANDIPTAT 758
L SD D N NC+ T N ++F + + S + T
Sbjct: 445 TSLLQSSDTPDALNRTLHAINCSTT-HFNADGSLWFSNSTCYNVIDTLSSTTSEPTITIG 503
Query: 759 ARTSTVLVIILVIASLFLAVLAIIGYNFRQKAKA---KKEAVKMTMVL----TGCEDNEP 811
T V++ ++ S F+ +L + F +K K K VL T
Sbjct: 504 DHTEIVMIAAPIVGSAFVLILLLTTVYFIKKLKKGNRSKPYWTRDPVLEWGSTATMQEPK 563
Query: 812 LRPTNVK----PNLAKLRIVKEAELRRG-GMLGFGAFGKVYKGVWVPEGENVKIPVAIKV 866
LR T+ + L K ++ ++L+ +G GAFGKVYKG+ + + E+ VAIK
Sbjct: 564 LRLTDDELQYYKGLFKDSLITYSQLQCDKDPIGEGAFGKVYKGL-LTQAESSVEHVAIKT 622
Query: 867 LKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMT---NQMMLITQLMPLGCLVDYVR 923
+K G + + F E M S HPN+++L +C +++ M G L Y+
Sbjct: 623 IKIFAGIESIRSFFTECASMTSFRHPNIIELFGMCFDAPDGTPLMVLPFMINGNLKSYLV 682
Query: 924 THKEKIGSKA--FLN---------WCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVK 972
+ + K F N CT IARGM+Y ++R VHRDLAARN L+ +VK
Sbjct: 683 KSRNPLSEKPDIFPNELGLAVMTKMCTDIARGMSYFVDQRFVHRDLAARNCLLDHDLTVK 742
Query: 973 ITDFGLAKLLDINEDEYKAAG-GKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYG 1031
I DFGLA+ + + YKA+ +P+KW+A E ++ I K+DVWA+GVT WE+ S G
Sbjct: 743 IGDFGLARNVYMT-GYYKASTRAALPVKWMAPEMLRDGISNEKTDVWAYGVTCWEVFSLG 801
Query: 1032 ARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
+ PY + V E + G +L +P +C Y ++ CW + RP F Q+ + +
Sbjct: 802 STPYPGVDNHLVLEHLMKGFRLAKPFLCFEKNYQILQRCWSNNPGDRPCFSQILNEMEAL 861
Query: 1092 ARDP 1095
P
Sbjct: 862 VNVP 865
>UniRef50_UPI0000DB7B4C Cluster: PREDICTED: similar to hopscotch
CG1594-PA; n=1; Apis mellifera|Rep: PREDICTED: similar to
hopscotch CG1594-PA - Apis mellifera
Length = 1133
Score = 168 bits (408), Expect = 1e-39
Identities = 99/274 (36%), Positives = 151/274 (55%), Gaps = 18/274 (6%)
Query: 836 GMLGFGAFGKVYKGVWVPE-GENVKIP-VAIKVLKETTGANTS-KEFLEEAYIMASVEHP 892
G +G G +G+VY+G E G++++ VAIK LK+ T +F E IM ++ HP
Sbjct: 856 GKIGQGFYGEVYRGTLERENGKDIEPQQVAIKKLKKKRALETDINDFEREITIMKTLNHP 915
Query: 893 NLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKR 952
N++++L V ++ L+ + + G L Y+ HK+++ + L + IA GM YL +
Sbjct: 916 NVVKILGVISEPEVCLVMEYVKHGSLQSYLAIHKQELTHRRLLGFALDIATGMDYLGSEG 975
Query: 953 LVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFT 1012
+VHRDLAARN+LV N VKI+DFGLA+++ N+ +PIKW A E I+ F+
Sbjct: 976 IVHRDLAARNILVADENKVKISDFGLAQVIGENDYYILQTDRSLPIKWYAPESIRDGKFS 1035
Query: 1013 HKSDVWAFGVTIWEILSYGARP-----------YENISARNVPEL---IENGLKLPQPSI 1058
+SDVW+FGVT++E S+G P +N + EL +ENG++LP P
Sbjct: 1036 IRSDVWSFGVTMYETFSFGEEPRLPGLDSSTERLQNEQEKGSTELLAALENGIRLPCPFT 1095
Query: 1059 CTLDIYC-VMVSCWMLDADSRPTFKQLADTFAEM 1091
C IY +M CW L + RP F L ++
Sbjct: 1096 CPQAIYVKLMHPCWNLKSHKRPDFATLCKDIEDL 1129
Score = 90.6 bits (215), Expect = 3e-16
Identities = 69/244 (28%), Positives = 127/244 (52%), Gaps = 20/244 (8%)
Query: 846 VYKGVW-VPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTN 904
+++ +W + +G+ K+ VA+K+LK+ AN +KEFLE A + + L++L + +T
Sbjct: 450 LHRAIWRLTKGK--KLEVALKILKQEEEANYTKEFLELAGKWSQLRSGTLVRLYGLTVTP 507
Query: 905 QMMLITQLMPLGCLVDYVRTHKEK-IGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNV 963
+ ++ +L+ G L +Y+R+ + I + + +A + +LEE +VH ++ +
Sbjct: 508 SIGMLLELVRHGSLDEYLRSSSSQTIKTVDMVEATACLAAALWHLEENGVVHGNIRCNKL 567
Query: 964 LVQ--TPNS--VKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWA 1019
LV T NS VK+ D G+ +++ P + LE +H + ++D+WA
Sbjct: 568 LVHAHTNNSFVVKLADPGIFVYTEMDIHWLP------PETYNDLELARH---SFQADIWA 618
Query: 1020 FGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRP 1079
G TIW+I + G E + V + E G +LP P+ C ++Y +M+ CW DS
Sbjct: 619 VGTTIWQIFARGDTLQEFSNVTIVKKHYEAGKRLPIPNGCPTEVYRLMLECW---GDSNG 675
Query: 1080 TFKQ 1083
+ KQ
Sbjct: 676 SRKQ 679
>UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 1084
Score = 168 bits (408), Expect = 1e-39
Identities = 106/324 (32%), Positives = 158/324 (48%), Gaps = 18/324 (5%)
Query: 788 QKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVY 847
Q K ++ + ++T N N K + L RG LG GAFG+VY
Sbjct: 457 QSPDCKLSKLRASTIMTDYNPNYCFAGKTASVNDLKEVSRRNISLTRG--LGHGAFGEVY 514
Query: 848 KGVWVP-EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ- 905
+G+ V GE + VA+K L E +FL EA I++ H N+++ + V +
Sbjct: 515 EGLAVGIPGEPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFSHQNIVRCVGVSLQAMP 574
Query: 906 MMLITQLMPLGCLVDYVRT------HKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLA 959
++ +LM G L ++R H + LN IA+G YLEE + +HRD+A
Sbjct: 575 RFILLELMTGGDLKTFMRETRPRPEHPSSLTMVDLLNIARDIAKGCQYLEENQFIHRDIA 634
Query: 960 ARNVLV--QTPNSV-KITDFGLAKLLDINEDEYKAAGGK--MPIKWLALECIQHRIFTHK 1014
ARN L+ + P V KI DFG+A+ DI Y GG+ +P+KW+ E IFT K
Sbjct: 635 ARNCLLTCKGPGRVAKIGDFGMAR--DIYRASYYRKGGRAMLPVKWMPPEAFMEGIFTSK 692
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
+D W+FGV +WEI S G PY + S + V E + NG ++ P C +Y +M CW
Sbjct: 693 TDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCPGPVYRIMTQCWQHQ 752
Query: 1075 ADSRPTFKQLADTFAEMARDPGRY 1098
+ RP F + + + P R+
Sbjct: 753 PEDRPNFSTILERI-DYCLQPARH 775
>UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome shotgun
sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF15039, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 978
Score = 167 bits (407), Expect = 1e-39
Identities = 104/351 (29%), Positives = 179/351 (50%), Gaps = 30/351 (8%)
Query: 761 TSTVLVIILVIASLFLAVLAIIGYN--FRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVK 818
T T + I+L + +LF ++ F ++ + +E + T P +PT
Sbjct: 610 TVTCVTILLALLALFFIRKMLLNRRRTFTYQSGSGEETILQFNSGTLTLTRRP-KPT--- 665
Query: 819 PNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKE 878
P I++ +++ ++G G FG+V K + +G K+ AIK+LKE N ++
Sbjct: 666 PEALTYPILEWEDIKFEDVIGEGNFGQVIKAMVKKDGN--KMSAAIKMLKEFASENDHRD 723
Query: 879 FLEEAYIMASV-EHPNLLQLLAVCMTNQMMLIT-QLMPLGCLVDYVRTHK---------- 926
F E ++ + +HPN++ L+ C + I + P G L+D++R +
Sbjct: 724 FAGELEVLCKLGQHPNIINLIGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAK 783
Query: 927 -----EKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKL 981
+ S+ L + +A GM YL +K+ +HRDLAARNVLV KI DFGL++
Sbjct: 784 EHGTASTLTSQQLLQFAVDVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSR- 842
Query: 982 LDINEDEY-KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISA 1040
E+ Y K G++P++W+A+E + + ++T KSDVW+FGV +WEI+S G PY ++
Sbjct: 843 ---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTC 899
Query: 1041 RNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
+ E + G ++ +P C ++Y +M CW RP F Q++ + M
Sbjct: 900 AELYEKLPQGFRMEKPKNCDDEVYELMKQCWRDRPYERPPFSQISVQLSRM 950
>UniRef50_O60674 Cluster: Tyrosine-protein kinase JAK2; n=48;
Euteleostomi|Rep: Tyrosine-protein kinase JAK2 - Homo
sapiens (Human)
Length = 1132
Score = 167 bits (407), Expect = 1e-39
Identities = 98/277 (35%), Positives = 152/277 (54%), Gaps = 20/277 (7%)
Query: 828 KEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMA 887
+E L+ LG G FG V + P +N VA+K L+ +T + ++F E I+
Sbjct: 845 EERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHL-RDFEREIEILK 903
Query: 888 SVEHPNLLQLLAVCMT---NQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARG 944
S++H N+++ VC + + LI + +P G L DY++ HKE+I L + +QI +G
Sbjct: 904 SLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKG 963
Query: 945 MAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKA-AGGKMPIKWLAL 1003
M YL KR +HRDLA RN+LV+ N VKI DFGL K+L +++ YK G+ PI W A
Sbjct: 964 MEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 1023
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSY---------------GARPYENISARNVPELIE 1048
E + F+ SDVW+FGV ++E+ +Y G + ++ EL++
Sbjct: 1024 ESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLK 1083
Query: 1049 NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLA 1085
N +LP+P C +IY +M CW + + RP+F+ LA
Sbjct: 1084 NNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA 1120
Score = 101 bits (243), Expect = 1e-19
Identities = 79/301 (26%), Positives = 144/301 (47%), Gaps = 13/301 (4%)
Query: 794 KEAVKMTMVLTGCEDNEPLRPTNVKP---NLAKLRIVKEAELRRGGMLGFGAFGKVYKGV 850
K+ + + T + P PT +P N ++ +L LG G F K++KGV
Sbjct: 504 KDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGV 563
Query: 851 WVPEGENVKI---PVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMT-NQM 906
G+ ++ V +KVL + N S+ F E A +M+ + H +L+ VC+ ++
Sbjct: 564 RREVGDYGQLHETEVLLKVL-DKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDEN 622
Query: 907 MLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQ 966
+L+ + + G L Y++ +K I L Q+A M +LEE L+H ++ A+N+L+
Sbjct: 623 ILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLI 682
Query: 967 TPNSVKITDFGLAKLLD--INEDEYKAAGGKMPIKWLALECIQH-RIFTHKSDVWAFGVT 1023
K + KL D I+ + I W+ ECI++ + +D W+FG T
Sbjct: 683 REEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTT 742
Query: 1024 IWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQ 1083
+WEI S G +P + ++ + E+ +LP P ++ ++ +C + D RP+F+
Sbjct: 743 LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRA 800
Query: 1084 L 1084
+
Sbjct: 801 I 801
>UniRef50_Q10925-2 Cluster: Isoform b of Q10925 ; n=2; Caenorhabditis
elegans|Rep: Isoform b of Q10925 - Caenorhabditis elegans
Length = 1130
Score = 167 bits (406), Expect = 2e-39
Identities = 92/273 (33%), Positives = 155/273 (56%), Gaps = 7/273 (2%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYI 885
++ +++ ++G G+F V +G W + + VA+K+L++ + N + EA
Sbjct: 101 LIPNEQIKLYELIGEGSFAVVKRGTWT-QSNGTHVNVAVKILRDIS-PNIMDDLRVEASH 158
Query: 886 MASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLN-WCTQIARG 944
+ ++HP+L++L + + M++ +L G L+D +R K+ I + L+ +C QIA+
Sbjct: 159 LLKLQHPSLIRLYGI-VRQPAMMVFELCEGGSLLDRLRDDKKAILLVSRLHDYCMQIAKA 217
Query: 945 MAYLEEKRLVHRDLAARNVLV-QTPNSVKITDFGLAKLLDINEDEYKAAGGK-MPIKWLA 1002
+ +LE K VHRD+AARN+L+ + +VKI DFGL + L NE Y A K +P W
Sbjct: 218 LQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFAWCP 277
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLD 1062
E ++HR F+H SDVW++GVTIWE+ ++G P+ A +V + I+ G +L +P C+
Sbjct: 278 PEALRHRKFSHASDVWSYGVTIWEVFTFGEEPWVGCRAIDVLKNIDAGERLEKPKYCSER 337
Query: 1063 IYCVMVSCWMLDADSRPTFKQL-ADTFAEMARD 1094
IY +M +CW + R F + D A M D
Sbjct: 338 IYQIMKNCWKFNPAERCKFGAIREDLVAAMFLD 370
>UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|Rep:
Bm-DAF-2 precursor - Brugia malayi (Filarial nematode
worm)
Length = 1456
Score = 167 bits (406), Expect = 2e-39
Identities = 124/371 (33%), Positives = 190/371 (51%), Gaps = 35/371 (9%)
Query: 761 TSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNV-KP 819
T+TV+ I VI L L++ ++ Y +K +K + ++ + E L +V KP
Sbjct: 977 TTTVVSFIAVIVLLVLSIGSLAAYYISRKILGEKVREYVRQQISA--NPEYLSQMDVYKP 1034
Query: 820 NLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPV-------AIKVLKETTG 872
+ +L K + + +G G FGKVY+G G+N K + AIK + ET
Sbjct: 1035 DEWEL---KRSAIHLEDEIGRGTFGKVYRGY----GDNCKSYLGVTFGECAIKTVSETAN 1087
Query: 873 ANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLIT-QLMPLGCLVDYVRTHK----E 927
+ FL EA +M P +++L V Q +L+ ++M G L DY+R+ + E
Sbjct: 1088 SAERLHFLIEASVMKQFNTPFIVKLYGVVSDGQPVLVVMEMMKKGNLRDYLRSRRPNAEE 1147
Query: 928 KI------GSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKL 981
+ G+ F W +Q+A GMAYLE + HRDLAARN +V ++VKI DFG+A+
Sbjct: 1148 NVNGLPVPGAIDFFRWASQVADGMAYLESLKFCHRDLAARNCMVNEFDTVKIGDFGMAR- 1206
Query: 982 LDINEDEYKAAGGK--MPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENIS 1039
DI EY GK MP++W+A E + FT KSDVW++G+T++E+L+ +PY ++
Sbjct: 1207 -DIYYHEYYKPAGKRLMPVRWMAPESLMDGKFTMKSDVWSYGITLYEMLTLAQQPYLGLA 1265
Query: 1040 ARNVPELIENGLK-LPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRY 1098
+V + I K L +P+ C Y +M CW D RPTF Q+ A G
Sbjct: 1266 NESVFDYIGVKKKILTRPTGCPDFWYELMKRCWKYDPRERPTFAQIVGILLRHAE--GGI 1323
Query: 1099 LVIPGDKFMRL 1109
L P D+F +
Sbjct: 1324 LNFPDDEFREM 1334
Score = 77.0 bits (181), Expect = 3e-12
Identities = 105/476 (22%), Positives = 181/476 (38%), Gaps = 62/476 (13%)
Query: 20 NCTYVDGNLELTWLENESM---DLSFLKYIREVTGYVLI---SHVKVHKIVLPQLQIIRG 73
NCT ++G+ ++ + + + + K +R +TG++LI S ++ K + P L+II G
Sbjct: 49 NCTVMEGDFSVSMITSSNFTHENFPVFKRLRVITGHLLIFQVSALRSLKRLFPNLRIIGG 108
Query: 74 RTLFKLNVREEEFALLVTMSTAFT-LELPALRDVLQGSVGIYSNFNLCHVKTINWDEINQ 132
+ L +AL++ +T + LP L ++ G V I N LC+ + I+W +I
Sbjct: 109 QELIM------NYALVIYQNTHLVEIGLPKLTTIINGGVRIMDNTQLCYSRYIDWSQI-- 160
Query: 133 DLTQVTFTFIILPLGKGNARVVTQPARWAAGESIENCQK-------FSKTICSPQCA--- 182
I+ KG+ + ++ C K + C +C
Sbjct: 161 --LIGPANDILTDQNKGSDSDLCSDD--CVPQNEHRCHKRDHMLSCWDAETCQLECKYAW 216
Query: 183 -QGRCFGPNPRD---CCNTFCAGGCTGP-LPTQCLACRNFYDEGTCSQECP--SMQIYN- 234
+ GP D C+ C GGC+ P P+ C C+N +G C +CP +I++
Sbjct: 217 NDDKTVGPGCDDDGERCHDQCLGGCSAPDDPSACHFCKNVVYQGICMDKCPIGLYEIHHI 276
Query: 235 PTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNK---TAVNGECIPCVGTC 291
+ + + + +L C CP + + CI C G C
Sbjct: 277 YLVRRCVTIEECRNISAPVTMESTKKRMLIVENMCRVDCPFGQEIDPTTSSGCIKCEGYC 336
Query: 292 PKTCRAEKPIHSGNIDS--FKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDA 349
P C+ I+ FK C +I+G +EI E+ G + G
Sbjct: 337 PVKCKGGTIDSFARINDYLFKKCNVIEGYLEI-ELR-KGLDAAGME-KIG---------- 383
Query: 350 LEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYI--VKTXXXXX 407
E + + GYL + +F SL F+ L +I G + + +A
Sbjct: 384 -EALGYIEVIEGYLLID-FSISFISLHMFKRLRLIKGSILYRDRYALAIFENANLRQIFD 441
Query: 408 XXXXXXXVNSGAIAIMENRNLCY---ADKIAWNKLVKSKDHKQIIQKNGDPRQCEK 460
+ +G + NR LCY I L K++ NGD C++
Sbjct: 442 IEKQPLVIGNGTVLFQNNRMLCYNRIKALIDHTGLTDVKENDVSYYSNGDRAVCDE 497
Score = 64.9 bits (151), Expect = 1e-08
Identities = 62/250 (24%), Positives = 106/250 (42%), Gaps = 35/250 (14%)
Query: 311 DCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALEVFSTVREVTGYLNVQAHHP 370
+CT+++G + +T + F E +P VF +R +TG+L +
Sbjct: 49 NCTVMEGDFSVSMITSSNFTH--------ENFP--------VFKRLRVITGHLLIFQVSA 92
Query: 371 NFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXXXXXXXXXXXVNSGAIAIMENRNLCY 430
+ F NL +IGG++++ N +A + T + +G + IM+N LCY
Sbjct: 93 LRSLKRLFPNLRIIGGQELIMN-YALVIYQNTHLVEIGLPKLTTIINGGVRIMDNTQLCY 151
Query: 431 ADKIAWNKLV--KSKDHKQIIQKNGDPRQCE-----KNNLVCDPQCSADGCWGPGPDQCL 483
+ I W++++ + D K D C +N C + CW Q L
Sbjct: 152 SRYIDWSQILIGPANDILTDQNKGSDSDLCSDDCVPQNEHRCHKRDHMLSCWDAETCQ-L 210
Query: 484 SCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCTGASRAN-CTSCKHVRDGPY 542
C+ Y + D+ +V PG D ++CH +CL GC+ + C CK+V
Sbjct: 211 ECK-YAWN----DDKTVGPG---CDDDG-ERCHDQCLGGCSAPDDPSACHFCKNVVYQGI 261
Query: 543 CVAQCPESRY 552
C+ +CP Y
Sbjct: 262 CMDKCPIGLY 271
Score = 37.5 bits (83), Expect = 2.6
Identities = 19/53 (35%), Positives = 26/53 (49%), Gaps = 4/53 (7%)
Query: 458 CEKNNLVCDPQCSADGCWGPG-PDQCLSCQNYNFGEICIDNCSVHPGLYKADH 509
C+ + C QC GC P P C C+N + IC+D C + GLY+ H
Sbjct: 226 CDDDGERCHDQCLG-GCSAPDDPSACHFCKNVVYQGICMDKCPI--GLYEIHH 275
>UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3; Eutheria|Rep:
HOOK3-RET fusion protein - Homo sapiens (Human)
Length = 776
Score = 167 bits (406), Expect = 2e-39
Identities = 94/283 (33%), Positives = 156/283 (55%), Gaps = 27/283 (9%)
Query: 835 GGMLGFGAFGKVYKGV-WVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPN 893
G LG G FGKV K + +G VA+K+LKE + ++ L E ++ V HP+
Sbjct: 389 GKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPH 448
Query: 894 LLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHKEK----IGSKA--------------- 933
+++L C + ++LI + G L ++R ++ +GS
Sbjct: 449 VIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERAL 508
Query: 934 ----FLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY 989
+++ QI++GM YL E +LVHRDLAARN+LV +KI+DFGL++ + ED Y
Sbjct: 509 TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YEEDSY 567
Query: 990 -KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE 1048
K + G++P+KW+A+E + I+T +SDVW+FGV +WEI++ G PY I + L++
Sbjct: 568 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 627
Query: 1049 NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
G ++ +P C+ ++Y +M+ CW + D RP F ++ +M
Sbjct: 628 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM 670
>UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase
receptor ret precursor; n=59; Eumetazoa|Rep:
Proto-oncogene tyrosine-protein kinase receptor ret
precursor - Homo sapiens (Human)
Length = 1114
Score = 167 bits (406), Expect = 2e-39
Identities = 94/283 (33%), Positives = 156/283 (55%), Gaps = 27/283 (9%)
Query: 835 GGMLGFGAFGKVYKGV-WVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPN 893
G LG G FGKV K + +G VA+K+LKE + ++ L E ++ V HP+
Sbjct: 727 GKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPH 786
Query: 894 LLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHKEK----IGSKA--------------- 933
+++L C + ++LI + G L ++R ++ +GS
Sbjct: 787 VIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERAL 846
Query: 934 ----FLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY 989
+++ QI++GM YL E +LVHRDLAARN+LV +KI+DFGL++ + ED Y
Sbjct: 847 TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YEEDSY 905
Query: 990 -KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIE 1048
K + G++P+KW+A+E + I+T +SDVW+FGV +WEI++ G PY I + L++
Sbjct: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
Query: 1049 NGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEM 1091
G ++ +P C+ ++Y +M+ CW + D RP F ++ +M
Sbjct: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM 1008
>UniRef50_Q10925 Cluster: Probable tyrosine-protein kinase kin-25;
n=2; Caenorhabditis|Rep: Probable tyrosine-protein kinase
kin-25 - Caenorhabditis elegans
Length = 1237
Score = 167 bits (406), Expect = 2e-39
Identities = 92/273 (33%), Positives = 155/273 (56%), Gaps = 7/273 (2%)
Query: 826 IVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYI 885
++ +++ ++G G+F V +G W + + VA+K+L++ + N + EA
Sbjct: 101 LIPNEQIKLYELIGEGSFAVVKRGTWT-QSNGTHVNVAVKILRDIS-PNIMDDLRVEASH 158
Query: 886 MASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLN-WCTQIARG 944
+ ++HP+L++L + + M++ +L G L+D +R K+ I + L+ +C QIA+
Sbjct: 159 LLKLQHPSLIRLYGI-VRQPAMMVFELCEGGSLLDRLRDDKKAILLVSRLHDYCMQIAKA 217
Query: 945 MAYLEEKRLVHRDLAARNVLV-QTPNSVKITDFGLAKLLDINEDEYKAAGGK-MPIKWLA 1002
+ +LE K VHRD+AARN+L+ + +VKI DFGL + L NE Y A K +P W
Sbjct: 218 LQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFAWCP 277
Query: 1003 LECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLD 1062
E ++HR F+H SDVW++GVTIWE+ ++G P+ A +V + I+ G +L +P C+
Sbjct: 278 PEALRHRKFSHASDVWSYGVTIWEVFTFGEEPWVGCRAIDVLKNIDAGERLEKPKYCSER 337
Query: 1063 IYCVMVSCWMLDADSRPTFKQL-ADTFAEMARD 1094
IY +M +CW + R F + D A M D
Sbjct: 338 IYQIMKNCWKFNPAERCKFGAIREDLVAAMFLD 370
>UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to
ENSANGP00000019144; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000019144 - Nasonia
vitripennis
Length = 1220
Score = 167 bits (405), Expect = 2e-39
Identities = 94/282 (33%), Positives = 157/282 (55%), Gaps = 18/282 (6%)
Query: 831 ELRRGGMLGFGAFGKVYKGVW--VPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMAS 888
+LR +LG G FG+V+K + + VA+K +KE ++ + E IM
Sbjct: 921 KLRLQTVLGEGNFGQVWKAEADDLTGHQGTTRLVAVKTVKEGASDREKEDLVRELEIMQR 980
Query: 889 V-EHPNLLQLLAVCMTNQM-MLITQLMPLGCLVDYVRTHKEK------------IGSKAF 934
V HPN++ LL C + LI + + G L+ Y+R H+ + + S+
Sbjct: 981 VGSHPNVVTLLGCCTEQEPHYLILEYVMYGKLLAYLRDHRTRQDFYNFSEDSAALTSRDL 1040
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG 994
+ +ARGM YL K+++HRDLAARNVLV KI DFG+++ + + + + G
Sbjct: 1041 TVFGYCVARGMEYLASKKIIHRDLAARNVLVDHNKLCKIADFGMSRFANEDGEVIETRHG 1100
Query: 995 K--MPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLK 1052
+ +PI+W+A E + + +FT K+DVW+FG+ +WEI++ G+ PY +++AR V +++G +
Sbjct: 1101 RNALPIRWMAPESLIYSLFTTKTDVWSFGILMWEIVTLGSTPYPDMTAREVMRSVQSGYR 1160
Query: 1053 LPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARD 1094
L +PS C +++ V+ CW D D RP F+ L A++ D
Sbjct: 1161 LERPSHCRSELFRVIARCWHADPDRRPEFQLLRRDLAQLLED 1202
>UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome undetermined SCAF14764, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 635
Score = 167 bits (405), Expect = 2e-39
Identities = 95/277 (34%), Positives = 152/277 (54%), Gaps = 24/277 (8%)
Query: 832 LRRGGMLGFGAFGKVY--KGVWVPEGENVKIP-VAIKVLKETTGANTSKEFLEEAYIMAS 888
L G LG G FG+V + V + + + ++ VA+K+LK + + E +M
Sbjct: 348 LTLGKPLGEGCFGQVVLAEAVGLDKNKPARVTKVAVKMLKADATEKDRADLISEMEMMKM 407
Query: 889 V-EHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVRTHKE------------KIGSKAF 934
+ +H N++ LL C + + ++ + G L DY+R + + S
Sbjct: 408 IGKHKNIINLLGACTQDGPLYVLVEYASKGNLRDYLRARRPAGLEYWSSSRPVSLASMEI 467
Query: 935 LNWCT---QIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEY-- 989
+ + Q+ARGMAYL K+ +HRDLAARNVLV N +KI DFGLA+ D++ +Y
Sbjct: 468 MELVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR--DVHHIDYYK 525
Query: 990 KAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIEN 1049
K G++P+KW+A E + RI+TH+SDVW+FGV +WEI + G PY + + +L++
Sbjct: 526 KTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKE 585
Query: 1050 GLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
G ++ +P T ++Y +M CW RPTF+QL +
Sbjct: 586 GHRMEKPPTSTQELYLMMRGCWHAVPARRPTFQQLVE 622
>UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000019144 - Anopheles gambiae
str. PEST
Length = 687
Score = 167 bits (405), Expect = 2e-39
Identities = 90/279 (32%), Positives = 158/279 (56%), Gaps = 17/279 (6%)
Query: 837 MLGFGAFGKVYK--GVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVE-HPN 893
+LG GAFG+V++ + E V + A+K LKE + L E ++ S+E H N
Sbjct: 389 ILGEGAFGQVWRCEATDIDGHEGVSV-TAVKTLKENASEAERNDLLSELQVLKSLEPHIN 447
Query: 894 LLQLLAVCMTNQ-MMLITQLMPLGCLVDYVR----------TH-KEKIGSKAFL-NWCTQ 940
+++LL C + +I + + +G L ++R TH K KI + L ++ Q
Sbjct: 448 VVRLLGCCTEKDPIFVILEYVNMGKLQTFLRNSRVEKHYGNTHGKSKILTSGDLTSFMYQ 507
Query: 941 IARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKW 1000
+ARGM +L + ++HRDLAARN+L+ ++ K+ DFG A+ + ++ + + G++PI+W
Sbjct: 508 VARGMDFLTSRGIIHRDLAARNILITDDHTCKVADFGFARDIVTSKVYERKSEGRLPIRW 567
Query: 1001 LALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICT 1060
+A E + IFT KSD+W+FG+ +WEI++ G+ PY I+A +V + +G +L +P C
Sbjct: 568 MATESLYDNIFTVKSDIWSFGILMWEIVTLGSTPYPGIAAADVMRKVRDGYRLEKPEHCR 627
Query: 1061 LDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYL 1099
++Y +M CW D + RP F ++ + + + Y+
Sbjct: 628 RELYNIMFYCWAADPNERPGFPEVVEMLDRLLQTETDYI 666
>UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic
lymphoma kinase (Ki-1),; n=1; Danio rerio|Rep: PREDICTED:
similar to anaplastic lymphoma kinase (Ki-1), - Danio
rerio
Length = 1387
Score = 166 bits (404), Expect = 3e-39
Identities = 106/321 (33%), Positives = 156/321 (48%), Gaps = 17/321 (5%)
Query: 788 QKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVY 847
Q K ++ + ++T N N K + L RG LG GAFG+VY
Sbjct: 753 QSPDCKLSKLRASTIMTDYNPNYCFGGKTASVNDLKEVPRRNISLTRG--LGHGAFGEVY 810
Query: 848 KGVWVP-EGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTN-Q 905
+G+ V GE + VA+K L E +FL EA I++ H N+++ + V +
Sbjct: 811 EGLAVGIPGEPSPMQVAVKTLPEVCSEQDELDFLMEALIISKFSHQNIVRCIGVSLQALP 870
Query: 906 MMLITQLMPLGCLVDYVRT------HKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLA 959
++ +LM G L ++R H + LN IARG YLEE + +HRD+A
Sbjct: 871 HFILLELMAGGDLKSFLRETRPRLEHPSSLTMVDLLNIARDIARGCQYLEENQFIHRDIA 930
Query: 960 ARNVLV--QTPNSV-KITDFGLAKLLDINEDEYKAAGGK--MPIKWLALECIQHRIFTHK 1014
ARN L+ + P V KI DFG+A+ DI Y GG+ +P+KW+ E IFT K
Sbjct: 931 ARNCLLTCKGPGRVAKIGDFGMAR--DIYRASYYRKGGRAMLPVKWMPPEAFMEGIFTSK 988
Query: 1015 SDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLD 1074
+D W+FGV +WEI S G PY + S + V E + NG ++ P C +Y +M W
Sbjct: 989 TDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCPGPVYRIMTQSWQHQ 1048
Query: 1075 ADSRPTFKQLADTFAEMARDP 1095
+ RP F + + +DP
Sbjct: 1049 PEDRPNFSTILERIDYCLQDP 1069
>UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5;
Euteleostomi|Rep: Tyrosine-protein kinase receptor -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 1161
Score = 166 bits (404), Expect = 3e-39
Identities = 98/289 (33%), Positives = 144/289 (49%), Gaps = 15/289 (5%)
Query: 820 NLAKLRIVKEAELRRGGMLGFGAFGKVYKG-VWVPEGENVKIPVAIKVLKETTGANTSKE 878
+L++L+ V + LG GAFG+VY+G V GEN + VAIK L E +
Sbjct: 554 SLSELKEVPRKNITLLRALGHGAFGEVYEGQVLGMNGENTAMQVAIKTLPEICSEQDEMD 613
Query: 879 FLEEAYIMASVEHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVR------THKEKIGS 931
FL EA IM+ H N+++ + V + ++ +LM G + ++R H +
Sbjct: 614 FLMEALIMSKFSHQNIVRCIGVSLQILPRFILLELMTGGDMKSFLRLNRPRTNHSSSLSM 673
Query: 932 KAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNS---VKITDFGLAKLLDINEDE 988
L+ IA G YLEE +HRD+AARN L+ P KI DFG+A+ DI
Sbjct: 674 LELLHMARDIALGCRYLEENHFIHRDIAARNCLLTCPGPDRVAKIGDFGMAR--DIYRAS 731
Query: 989 YKAAGGK--MPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPEL 1046
Y GG+ +P+KW+ E IFT K+D W+FGV +WEI S G PY + + V E
Sbjct: 732 YYRKGGRAMLPVKWMPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEF 791
Query: 1047 IENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDP 1095
+ G ++ P C +Y +M CW + RP F + + +DP
Sbjct: 792 VTGGGRMDPPKSCPGPVYRIMTQCWQHCPEHRPNFTTILERINYCTQDP 840
>UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1373
Score = 166 bits (404), Expect = 3e-39
Identities = 82/229 (35%), Positives = 132/229 (57%), Gaps = 8/229 (3%)
Query: 862 VAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQ--MMLITQLMPLGCLV 919
+ + V T A ++FL+E IM H N+L LL + + + +++ M G L
Sbjct: 1120 IFVSVSSGITDAEEVEQFLKEGIIMKGFHHCNVLSLLGILLPQEGLPLVVLPYMKHGDLR 1179
Query: 920 DYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLA 979
++R K K + + Q+A GM YL +K+ VHRDLAARN ++ +VK+ DFG+A
Sbjct: 1180 HFIRCEKRNPTVKDLIGFGLQVATGMEYLAQKKFVHRDLAARNCMLDESYTVKVADFGMA 1239
Query: 980 KLLDINEDEYKAAGG----KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPY 1035
+ D+ + EY + K+P+KW+A+E +Q + FT KSDVW+FGV +WE+L+ GA PY
Sbjct: 1240 R--DVLDKEYYSVQNHRKAKLPVKWMAIESLQTQKFTPKSDVWSFGVLMWEMLTRGASPY 1297
Query: 1036 ENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQL 1084
++ ++ + G +LPQP C +Y +M+ CW + + RP+F L
Sbjct: 1298 PDVDPYDITHYLLRGRRLPQPQFCPDPLYRIMLQCWDPEPELRPSFATL 1346
>UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase VIII - Ciona
intestinalis (Transparent sea squirt)
Length = 895
Score = 166 bits (404), Expect = 3e-39
Identities = 121/395 (30%), Positives = 189/395 (47%), Gaps = 44/395 (11%)
Query: 751 ANDIPTATARTSTVLVIILVIASLFLAV--LAIIGYNFRQKAKAKKEAVKMTMVLTG-CE 807
A P A + ++II V+ SL + V LA +F +K K+ V G
Sbjct: 442 ATSSPIANVKDDATIIIIAVVVSLAIIVIILAAAFRHFYRKRLTKQSVTANPNVTYGPVA 501
Query: 808 DNEPLRPTNV----KPNLAKLRIVKEAE------------LRRGGMLGFGAFGKVYKGVW 851
LR N + + IV++ E L+ G +LG G FG VYK
Sbjct: 502 TGNTLRSENAYYTSMSSTGSISIVQQLEELVQDVLIENKRLKLGKILGEGEFGFVYKATI 561
Query: 852 VPEGEN---------VKIPVAIKVLKETTGANTSKE-FLEEAYIMASVEHPNLLQLLAVC 901
+ + V+ VA+K +K T T E F++E M ++HPN++ L+ +
Sbjct: 562 SADANSNNNSNQTATVQGHVAVKSIKVTGHTYTEVEGFVKEGLRMKDLDHPNVMALIGIA 621
Query: 902 MTNQ-------MMLITQLMPLGCLVDYV---RTH--KEKIGSKAFLNWCTQIARGMAYLE 949
T + +++ MP G L Y+ RT EK + L + +A+GM YL
Sbjct: 622 FTAEDLNKPASPLVVLPYMPNGDLRSYLFSMRTAGLSEKFTVQKLLLFALDVAKGMQYLS 681
Query: 950 EKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAG-GKMPIKWLALECIQH 1008
+ +HRDLAARN ++ V ++DFGL++ + +E Y+ KMP+KW+ALE +
Sbjct: 682 NRNFIHRDLAARNCMLDENYKVVVSDFGLSRTV-YSESYYRQTHISKMPVKWMALESLAD 740
Query: 1009 RIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDI-YCVM 1067
IFT SDVW+FGVT+WEIL+ G PY + V +L+ NG +L +P C + + V+
Sbjct: 741 NIFTPLSDVWSFGVTVWEILTMGQSPYPGVGNHEVYQLLRNGTRLNKPEHCPSKVWFSVV 800
Query: 1068 VSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIP 1102
CW + R TF +L + +E+ +P + P
Sbjct: 801 FPCWTVQVKDRITFDKLVEVLSEITCNPTEDIETP 835
>UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 280
Score = 166 bits (404), Expect = 3e-39
Identities = 91/261 (34%), Positives = 144/261 (55%), Gaps = 15/261 (5%)
Query: 838 LGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-EHPNLLQ 896
LG G FG V +G + E E + VAIK+LK K+ L E + + +H N++
Sbjct: 14 LGEGEFGIVMEGELLIEEEAPR-KVAIKMLKSDADRTDHKDMLRELDMFKGIGQHENVVS 72
Query: 897 LLAVCMTNQ-MMLITQLMPLGCLVDYVRTHK------------EKIGSKAFLNWCTQIAR 943
L+ C + +IT+ + G L++ +R + K+ K L AR
Sbjct: 73 LIGACTLGMPLYIITEFIAGGTLLELLRESRCITSSYVNANLVSKLSGKDLLKLALGAAR 132
Query: 944 GMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLAL 1003
GM ++ R VHRDLA RNVLV + KITDFGL++ + + A GGK+P+KW+A
Sbjct: 133 GMRHISGNRFVHRDLATRNVLVTEDLTAKITDFGLSRDIYSDGIYLNAKGGKLPLKWMAP 192
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDI 1063
E + ++T +SD+W+FGV +WE+ S+GA PY + + ++ +G +L +P +C +I
Sbjct: 193 ESLLDYVYTTQSDIWSFGVLMWEVWSFGAMPYSAVVPNELLSMLMSGFRLSRPPLCPEEI 252
Query: 1064 YCVMVSCWMLDADSRPTFKQL 1084
Y VM+SCW + + RP+F +L
Sbjct: 253 YDVMMSCWNAEPEVRPSFAKL 273
>UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome shotgun
sequence; n=2; Tetraodontidae|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 921
Score = 165 bits (402), Expect = 6e-39
Identities = 79/204 (38%), Positives = 123/204 (60%), Gaps = 6/204 (2%)
Query: 885 IMASVEHPNLLQLLAVCMTNQMMLITQ--LMPLGCLVDYVRTHKEKIGSKAFLNWCTQIA 942
I+ +HPN+++L+ VC Q + I + G + ++R + KA + +A
Sbjct: 710 ILKQYDHPNVVKLIGVCTQKQPIYIVMELIQGSGDFLTFLRNQGRDLKPKALVKMAENVA 769
Query: 943 RGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG--KMPIKW 1000
GMAYLE K+ +HRDLAARN LV NSVKI+DFG+++ D + Y A GG ++PIKW
Sbjct: 770 SGMAYLESKKCIHRDLAARNCLVAENNSVKISDFGMSRQDD--DGVYLAEGGLRQIPIKW 827
Query: 1001 LALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICT 1060
A E + + +T +SDVW+FG+ +WE S G PY ++S + + +E G ++P P C
Sbjct: 828 TAPEALNYGRYTTQSDVWSFGILLWETFSLGLTPYMSMSNQQTRDEVEKGYRMPAPHACP 887
Query: 1061 LDIYCVMVSCWMLDADSRPTFKQL 1084
++I +M +CW D +RP+FK+L
Sbjct: 888 VEIARIMNNCWQYDPQNRPSFKKL 911
>UniRef50_Q4SFK0 Cluster: Chromosome 7 SCAF14601, whole genome shotgun
sequence; n=2; Tetraodontidae|Rep: Chromosome 7
SCAF14601, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 993
Score = 165 bits (402), Expect = 6e-39
Identities = 111/336 (33%), Positives = 174/336 (51%), Gaps = 40/336 (11%)
Query: 819 PNLAKLRIVKEAEL---RRGGMLGFGAFGKVYKG-VWVPEGENVKIPVAIKVLKETTGAN 874
PN A KE ++ + ++G G FG+V +G + +P + +P IK LK
Sbjct: 583 PNEAVREFAKEIDVSFVKIEEVIGAGEFGEVCRGRLKIPGKKENYVP--IKTLKGGYTDK 640
Query: 875 TSKEFLEEAYIMASVEHPNLLQLLAVCMTN-QMMLITQLMPLGCLVDYVR---THKEKIG 930
++FL EA IM +HPN++ L V + +M++T+ M G L ++R THK
Sbjct: 641 QRRDFLSEASIMGQFQHPNIIHLEGVITASCPVMILTEFMENGALDSFLRVSATHKTHAK 700
Query: 931 SKA----------FLNWCTQ-------IARG--------MAYLEEKRLVHRDLAARNVLV 965
+++ FL + ARG M YL E VHRDLAARN+L+
Sbjct: 701 TRSAGPCRSLTEPFLFPVAERQPVHPHPARGDVRGIASGMKYLSEMSYVHRDLAARNILI 760
Query: 966 QTPNSVKITDFGLAKLLDINEDE--YKAA-GGKMPIKWLALECIQHRIFTHKSDVWAFGV 1022
+ K++DFGL++ L N + Y ++ GGK+PI+W A E I R FT SDVW++G+
Sbjct: 761 NSNLVCKVSDFGLSRFLQENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDVWSYGI 820
Query: 1023 TIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFK 1082
+WE++S+G RPY ++S ++V IE +LP P C ++ +M+ CW D +RP F
Sbjct: 821 VMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTHLHQLMLDCWQKDRSARPRFA 880
Query: 1083 QLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEK 1118
L ++ R+P ++ D PSY D++
Sbjct: 881 DLVSALDKLIRNPASLKIVAQDGVG--PSYPLLDQR 914
>UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (Xe-InsR) (XTK-1b) [Contains: Insulin receptor
subunit alpha; Insulin receptor subunit beta]; n=6;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (Xe-InsR) (XTK-1b) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Xenopus laevis (African clawed frog)
Length = 1362
Score = 165 bits (402), Expect = 6e-39
Identities = 95/270 (35%), Positives = 150/270 (55%), Gaps = 17/270 (6%)
Query: 838 LGFGAFGKVYKGVW--VPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLL 895
LG G+FG VY+G+ + +GE ++ VA+K + E+ EFL EA +M + +++
Sbjct: 1018 LGQGSFGMVYEGIAKDIIKGEP-EVRVAVKTVNESASLRERIEFLNEASVMKAFNCHHVV 1076
Query: 896 QLLAVCMTNQ-MMLITQLMPLGCLVDYVRTHKEKIGS---------KAFLNWCTQIARGM 945
+LL V Q ++I +LM G L Y+R+ + + K + +I+ GM
Sbjct: 1077 RLLGVVSKGQPTLVIMELMAHGDLKSYLRSLRPDAENNPGRLAPTLKEIIQMAAEISDGM 1136
Query: 946 AYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGK--MPIKWLAL 1003
AYL K+ VHRDLAARN +V +VKI DFG+ + DI E +Y GGK +P++W++
Sbjct: 1137 AYLNAKKFVHRDLAARNCMVADDYAVKIGDFGMTR--DIYETDYYRKGGKGLLPVRWMSP 1194
Query: 1004 ECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDI 1063
E ++ +FT SDVW+FGV +WEI S +PY+ +S V + + +G L P C +
Sbjct: 1195 ESLKDGVFTAFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGSLDHPENCPPRL 1254
Query: 1064 YCVMVSCWMLDADSRPTFKQLADTFAEMAR 1093
+ +M CW + RPTF ++ D + R
Sbjct: 1255 HSLMQMCWQYNPKMRPTFLEIIDMLKDDLR 1284
Score = 105 bits (252), Expect = 9e-21
Identities = 124/479 (25%), Positives = 198/479 (41%), Gaps = 65/479 (13%)
Query: 20 NCTYVDGNLE-LTWLENESMDLSFLKY--IREVTGYVLISHV---KVHKIVLPQLQIIRG 73
+CT ++G+L+ L ++ + L++ + +T Y+L+ V + K + P L +IRG
Sbjct: 62 DCTVIEGHLQILLMFTSKPENFRGLRFPKLTTITDYLLLFRVYGLESLKDLFPNLTVIRG 121
Query: 74 RTLFKLNVREEEFALLV-TMSTAFTLELPALRDVLQGSVGIYSNFNLCHVKTINWDEINQ 132
LF +AL++ M + L L ++ +GSV I N LC++ TI+W I
Sbjct: 122 TRLFF------NYALVIFEMVHXKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSII-- 173
Query: 133 DLTQVTFTFIILPLGK----GNARVVTQPARWAA------GESIENC--QKFSKTICSPQ 180
L V +I L G+ T + G +E C Q + +C
Sbjct: 174 -LDSVEDNYIELNRDNKEECGDVCPGTVKGKSKCKHTLVNGALVERCWTQDHCQKVCPSD 232
Query: 181 CAQGRCFGPNPRDCCNTFCAGGCTGPL-PTQCLACRNFYDEGTCSQECP--SMQIYNPTT 237
C C P+ + CC+ C G C P P++C ACR+F +EG C CP S Q
Sbjct: 233 CKGSGCL-PDGQ-CCHPECLGSCRKPNDPSECTACRHFQNEGVCVTACPKGSYQFQGWRC 290
Query: 238 YSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTA--VNGECIPCVGTCPKTC 295
+ + +CP +++ G C+ CP A C PC G CPK C
Sbjct: 291 IDFNTCQELNSRCQNSRDNSCPPYVI-HKGECMPDCPSGYIANSTTRTCTPCAGPCPKVC 349
Query: 296 ---RAEKPIHS-GNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALE 351
+ K I S + + CT+I+GS+ I G + + +E +
Sbjct: 350 TIFQNVKTIDSVTSAQELRGCTVINGSLII---NLRGGNNIATE---------LEAN--- 394
Query: 352 VFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXXXXX--- 408
+ E++GYL ++ + SLS+FR L +I G +V+E S Y +
Sbjct: 395 -LGLIEEISGYLKIRRSYA-LVSLSFFRKLRLIRG-EVLEAGNYSFYALDNPSLRQLWDW 451
Query: 409 XXXXXXVNSGAIAIMENRNLCYADKIAWNKLVKSK---DHKQIIQK-NGDPRQCEKNNL 463
+ G + N LC + ++ +K D I K NGD CE N L
Sbjct: 452 HKHNLTIIHGKLFFHHNPRLCLSQIHQMEEVTGTKGRQDKNDIATKTNGDQASCEDNLL 510
Score = 60.9 bits (141), Expect = 2e-07
Identities = 61/255 (23%), Positives = 105/255 (41%), Gaps = 31/255 (12%)
Query: 305 NIDSF---KDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALEVFSTVREVTG 361
NI F +DCT+I+G ++IL M F +++ G R+PK+ +T
Sbjct: 53 NISQFSMLEDCTVIEGHLQILLM----FTSKPENFR-GLRFPKLTT-----------ITD 96
Query: 362 YLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTXXXXXXXXXXXXVNSGAIA 421
YL + + + F NL VI G ++ N +A + + G++
Sbjct: 97 YLLLFRVYGLESLKDLFPNLTVIRGTRLFFN-YALVIFEMVHXKEIGLYNLMNITRGSVR 155
Query: 422 IMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCE---KNNLVCDPQCSADGCWGPG 478
I +N LCY I W+ ++ S + I + +C + +C G
Sbjct: 156 IEKNNELCYLSTIDWSIILDSVEDNYIELNRDNKEECGDVCPGTVKGKSKCKHTLVNGAL 215
Query: 479 PDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCTGAS-RANCTSCKHV 537
++C + + ++C +C G C CH ECL C + + CT+C+H
Sbjct: 216 VERCWTQDHCQ--KVCPSDCK---GSGCLPDGQC--CHPECLGSCRKPNDPSECTACRHF 268
Query: 538 RDGPYCVAQCPESRY 552
++ CV CP+ Y
Sbjct: 269 QNEGVCVTACPKGSY 283
>UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4 variant;
n=28; Eumetazoa|Rep: Fibroblast growth factor receptor 4
variant - Homo sapiens (Human)
Length = 1034
Score = 165 bits (401), Expect = 8e-39
Identities = 92/272 (33%), Positives = 144/272 (52%), Gaps = 20/272 (7%)
Query: 835 GGMLGFGAFGKVYKGVWV---PEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASV-E 890
G LG G FG+V + P + VA+K+LK+ + + E +M +
Sbjct: 702 GKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGR 761
Query: 891 HPNLLQLLAVC-MTNQMMLITQLMPLGCLVDYVRTHK------------EKIGSKAF--- 934
H N++ LL VC + +I + G L +++R + G +F
Sbjct: 762 HKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVL 821
Query: 935 LNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGG 994
++ Q+ARGM YLE ++ +HRDLAARNVLV N +KI DFGLA+ + + K + G
Sbjct: 822 VSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNG 881
Query: 995 KMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLP 1054
++P+KW+A E + R++TH+SDVW+FG+ +WEI + G PY I + L+ G ++
Sbjct: 882 RLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMD 941
Query: 1055 QPSICTLDIYCVMVSCWMLDADSRPTFKQLAD 1086
+P C ++Y +M CW RPTFKQL +
Sbjct: 942 RPPHCPPELYGLMRECWHAAPSQRPTFKQLVE 973
>UniRef50_Q15516 Cluster: Tyrosine kinase; n=1; Homo sapiens|Rep:
Tyrosine kinase - Homo sapiens (Human)
Length = 600
Score = 165 bits (401), Expect = 8e-39
Identities = 92/232 (39%), Positives = 138/232 (59%), Gaps = 13/232 (5%)
Query: 835 GGMLGFGAFGKVYKGVW-VPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPN 893
G +LG G G VY+G+W +PEG+ VKIPVAIK LK T AN KE L+EA +M +P+
Sbjct: 245 GKILGEGEKGTVYEGLWNIPEGKEVKIPVAIKTLKLDTMAN--KEILDEASVMKGFGNPH 302
Query: 894 LLQLLAVCMTNQMMLITQ--LMPLGCLVDYVRTHKEKIGS-----KAFLNWCTQIARGMA 946
+++LL +CMT+ + +IT+ L+ D H+ + L + IA GM
Sbjct: 303 VVRLLGICMTSTIYVITEYCLLVYRRNKDKAEQHRSNCAELNPPLQTLLKFMVDIALGME 362
Query: 947 YLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECI 1006
YL + +HRDLAARN +++ +V + DFGL+K + + + KMP+KW+A+E +
Sbjct: 363 YLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESL 422
Query: 1007 QHRIFTHKSDVWAFGVTIWEILS--YGARPYENISARNVPELIENGLKLPQP 1056
R++T KSDVWAFGVT+WEI + G PY + + + + +G +L QP
Sbjct: 423 ADRVYT-KSDVWAFGVTMWEIATTLRGMTPYPGVQNHEMYDYLLHGHRLKQP 473
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.135 0.424
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 1,639,645,603
Number of Sequences: 1657284
Number of extensions: 73225017
Number of successful extensions: 194805
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 4731
Number of HSP's successfully gapped in prelim test: 5322
Number of HSP's that attempted gapping in prelim test: 163345
Number of HSP's gapped (non-prelim): 23463
length of query: 1397
length of database: 575,637,011
effective HSP length: 110
effective length of query: 1287
effective length of database: 393,335,771
effective search space: 506223137277
effective search space used: 506223137277
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 79 (35.9 bits)
- SilkBase 1999-2023 -