Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000564-TA|BGIBMGA000564-PA|IPR001382|Glycoside
hydrolase, family 47
(533 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC006079-1|AAH06079.1| 699|Homo sapiens mannosidase, alpha, cla... 512 e-145
BC002953-1|AAH02953.1| 699|Homo sapiens mannosidase, alpha, cla... 512 e-145
AY358465-1|AAQ88830.1| 699|Homo sapiens MAN1B1 protein. 512 e-145
AL929554-19|CAH72887.1| 699|Homo sapiens mannosidase, alpha, cl... 512 e-145
AL807752-35|CAI12781.1| 699|Homo sapiens mannosidase, alpha, cl... 512 e-145
AF148509-1|AAF03215.1| 699|Homo sapiens alpha 1,2-mannosidase p... 512 e-145
AF145732-1|AAD45504.1| 663|Homo sapiens endoplasmic reticulum a... 512 e-145
BC063300-1|AAH63300.1| 641|Homo sapiens mannosidase, alpha, cla... 303 7e-82
AL358072-1|CAH71079.1| 641|Homo sapiens mannosidase, alpha, cla... 303 7e-82
AL157902-1|CAI22315.1| 641|Homo sapiens mannosidase, alpha, cla... 303 7e-82
AF027156-1|AAC26169.1| 641|Homo sapiens alpha 1,2-mannosidase I... 303 7e-82
AL078600-1|CAB75695.2| 653|Homo sapiens mannosidase, alpha, cla... 301 5e-81
AL022722-2|CAI20315.1| 653|Homo sapiens mannosidase, alpha, cla... 301 5e-81
X74837-1|CAA52831.1| 625|Homo sapiens Man9-mannosidase protein. 300 7e-81
AL031280-2|CAI19714.1| 630|Homo sapiens mannosidase, alpha, cla... 287 5e-77
AF261655-1|AAF97058.1| 630|Homo sapiens 1,2-alpha-mannosidase I... 287 5e-77
AL031280-1|CAI19713.1| 450|Homo sapiens mannosidase, alpha, cla... 285 2e-76
AB209275-1|BAD92512.1| 482|Homo sapiens mannosidase, alpha, cla... 267 8e-71
AL929554-1|CAH72871.2| 329|Homo sapiens mannosidase, alpha, cla... 255 3e-67
AL358072-2|CAH71080.1| 343|Homo sapiens mannosidase, alpha, cla... 205 3e-52
AL157902-4|CAI22318.1| 343|Homo sapiens mannosidase, alpha, cla... 205 3e-52
AK074559-1|BAC11060.1| 178|Homo sapiens .2.1.113). protein. 194 5e-49
AK023308-1|BAB14518.1| 618|Homo sapiens protein ( Homo sapiens ... 190 8e-48
AB209276-1|BAD92513.1| 185|Homo sapiens alpha 1,2-mannosidase v... 173 1e-42
AL096819-3|CAI21741.1| 932|Homo sapiens ER degradation enhancer... 160 1e-38
AF288393-1|AAG60613.1| 889|Homo sapiens C1orf22 protein. 159 2e-38
AF053626-1|AAC26201.1| 251|Homo sapiens alpha 1,2-mannosidase I... 154 9e-37
D86967-1|BAA13203.2| 666|Homo sapiens KIAA0212 protein. 145 3e-34
BC019088-1|AAH19088.1| 657|Homo sapiens ER degradation enhancer... 145 3e-34
AF053621-1|AAC26200.1| 358|Homo sapiens alpha 1,2-mannosidase I... 140 1e-32
CR457266-1|CAG33547.1| 578|Homo sapiens C20orf31 protein. 138 5e-32
BC016184-1|AAH16184.1| 578|Homo sapiens ER degradation enhancer... 138 5e-32
BC001371-1|AAH01371.1| 578|Homo sapiens ER degradation enhancer... 138 5e-32
AL356652-1|CAH73763.1| 578|Homo sapiens ER degradation enhancer... 138 5e-32
AL135844-1|CAI19292.1| 578|Homo sapiens ER degradation enhancer... 138 5e-32
AK023931-1|BAB14731.1| 578|Homo sapiens protein ( Homo sapiens ... 138 5e-32
AK001645-1|BAA91806.1| 578|Homo sapiens protein ( Homo sapiens ... 138 5e-32
BC065827-1|AAH65827.1| 367|Homo sapiens MAN1A1 protein protein. 127 1e-28
AL157902-2|CAI22316.1| 203|Homo sapiens mannosidase, alpha, cla... 121 6e-27
AY358580-1|AAQ88943.1| 541|Homo sapiens C20orf31 protein. 120 1e-26
AK127005-1|BAC86786.1| 223|Homo sapiens protein ( Homo sapiens ... 109 2e-23
BC105586-1|AAI05587.1| 242|Homo sapiens EDEM3 protein protein. 97 2e-19
AL157902-3|CAI22317.1| 97|Homo sapiens mannosidase, alpha, cla... 56 2e-07
>BC006079-1|AAH06079.1| 699|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 699
Score = 512 bits (1264), Expect = e-145
Identities = 247/451 (54%), Positives = 318/451 (70%), Gaps = 7/451 (1%)
Query: 85 NDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASDWFSLGLTIVDSLDTAYIMGLTDV 144
N RQ+ +++ F HAW+GY++ AWGHD LKPVS S+WF LGLT++D+LDT +I+GL
Sbjct: 247 NYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKE 306
Query: 145 FEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAF 204
FEE ++W+ ++L F K+ DVN FE TIRILGGLL+ ++ + D LFL KA D G+RLM AF
Sbjct: 307 FEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAF 366
Query: 205 SSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSE 264
+PS IPYSDVN+G AH P W+ ST AEVT++QLEFR+LSR +G+ F+EA V++
Sbjct: 367 RTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQ 426
Query: 265 KIHQLP-KKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLDD 323
IH L KK GLVP+FIN ++G F TLGAR DSYYEYLLKQW+Q GK LL+D
Sbjct: 427 HIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLED 486
Query: 324 YLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDW 383
Y+ IEGVR L + S P+K F+GEL+ G F+ KMDHL CFLPGTLALG +GLP
Sbjct: 487 YVEAIEGVRTHLLRHSEPSKLTFVGELAHG--RFSAKMDHLVCFLPGTLALGVYHGLPAS 544
Query: 384 HMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTD--DMYTKSADAHSLLRPEFIESL 441
HM +A+EL+ TCY T L+PEI HFNL D+ K AD H+LLRPE +ESL
Sbjct: 545 HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESL 604
Query: 442 WYMYQITGNTTYQEWGWQIFQGFEKYAKVPN-GYSSLTNVKS-ENPIPRDMMESFFLSET 499
+Y+Y++TG+ YQ+WGW+I Q F ++ +VP+ GYSS+ NV+ + P PRD MESFFL ET
Sbjct: 605 FYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGET 664
Query: 500 XXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
SDD L+ L+ YV N+EAHPLPI
Sbjct: 665 LKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>BC002953-1|AAH02953.1| 699|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 699
Score = 512 bits (1264), Expect = e-145
Identities = 247/451 (54%), Positives = 318/451 (70%), Gaps = 7/451 (1%)
Query: 85 NDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASDWFSLGLTIVDSLDTAYIMGLTDV 144
N RQ+ +++ F HAW+GY++ AWGHD LKPVS S+WF LGLT++D+LDT +I+GL
Sbjct: 247 NYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKE 306
Query: 145 FEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAF 204
FEE ++W+ ++L F K+ DVN FE TIRILGGLL+ ++ + D LFL KA D G+RLM AF
Sbjct: 307 FEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAF 366
Query: 205 SSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSE 264
+PS IPYSDVN+G AH P W+ ST AEVT++QLEFR+LSR +G+ F+EA V++
Sbjct: 367 RTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQ 426
Query: 265 KIHQLP-KKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLDD 323
IH L KK GLVP+FIN ++G F TLGAR DSYYEYLLKQW+Q GK LL+D
Sbjct: 427 HIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLED 486
Query: 324 YLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDW 383
Y+ IEGVR L + S P+K F+GEL+ G F+ KMDHL CFLPGTLALG +GLP
Sbjct: 487 YVEAIEGVRTHLLRHSEPSKLTFVGELAHG--RFSAKMDHLVCFLPGTLALGVYHGLPAS 544
Query: 384 HMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTD--DMYTKSADAHSLLRPEFIESL 441
HM +A+EL+ TCY T L+PEI HFNL D+ K AD H+LLRPE +ESL
Sbjct: 545 HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESL 604
Query: 442 WYMYQITGNTTYQEWGWQIFQGFEKYAKVPN-GYSSLTNVKS-ENPIPRDMMESFFLSET 499
+Y+Y++TG+ YQ+WGW+I Q F ++ +VP+ GYSS+ NV+ + P PRD MESFFL ET
Sbjct: 605 FYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGET 664
Query: 500 XXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
SDD L+ L+ YV N+EAHPLPI
Sbjct: 665 LKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AY358465-1|AAQ88830.1| 699|Homo sapiens MAN1B1 protein.
Length = 699
Score = 512 bits (1264), Expect = e-145
Identities = 247/451 (54%), Positives = 318/451 (70%), Gaps = 7/451 (1%)
Query: 85 NDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASDWFSLGLTIVDSLDTAYIMGLTDV 144
N RQ+ +++ F HAW+GY++ AWGHD LKPVS S+WF LGLT++D+LDT +I+GL
Sbjct: 247 NYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKE 306
Query: 145 FEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAF 204
FEE ++W+ ++L F K+ DVN FE TIRILGGLL+ ++ + D LFL KA D G+RLM AF
Sbjct: 307 FEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAF 366
Query: 205 SSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSE 264
+PS IPYSDVN+G AH P W+ ST AEVT++QLEFR+LSR +G+ F+EA V++
Sbjct: 367 RTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQ 426
Query: 265 KIHQLP-KKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLDD 323
IH L KK GLVP+FIN ++G F TLGAR DSYYEYLLKQW+Q GK LL+D
Sbjct: 427 HIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLED 486
Query: 324 YLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDW 383
Y+ IEGVR L + S P+K F+GEL+ G F+ KMDHL CFLPGTLALG +GLP
Sbjct: 487 YVEAIEGVRTHLLRHSEPSKLTFVGELAHG--RFSAKMDHLVCFLPGTLALGVYHGLPAS 544
Query: 384 HMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTD--DMYTKSADAHSLLRPEFIESL 441
HM +A+EL+ TCY T L+PEI HFNL D+ K AD H+LLRPE +ESL
Sbjct: 545 HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESL 604
Query: 442 WYMYQITGNTTYQEWGWQIFQGFEKYAKVPN-GYSSLTNVKS-ENPIPRDMMESFFLSET 499
+Y+Y++TG+ YQ+WGW+I Q F ++ +VP+ GYSS+ NV+ + P PRD MESFFL ET
Sbjct: 605 FYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGET 664
Query: 500 XXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
SDD L+ L+ YV N+EAHPLPI
Sbjct: 665 LKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AL929554-19|CAH72887.1| 699|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 699
Score = 512 bits (1264), Expect = e-145
Identities = 247/451 (54%), Positives = 318/451 (70%), Gaps = 7/451 (1%)
Query: 85 NDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASDWFSLGLTIVDSLDTAYIMGLTDV 144
N RQ+ +++ F HAW+GY++ AWGHD LKPVS S+WF LGLT++D+LDT +I+GL
Sbjct: 247 NYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKE 306
Query: 145 FEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAF 204
FEE ++W+ ++L F K+ DVN FE TIRILGGLL+ ++ + D LFL KA D G+RLM AF
Sbjct: 307 FEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAF 366
Query: 205 SSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSE 264
+PS IPYSDVN+G AH P W+ ST AEVT++QLEFR+LSR +G+ F+EA V++
Sbjct: 367 RTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQ 426
Query: 265 KIHQLP-KKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLDD 323
IH L KK GLVP+FIN ++G F TLGAR DSYYEYLLKQW+Q GK LL+D
Sbjct: 427 HIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLED 486
Query: 324 YLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDW 383
Y+ IEGVR L + S P+K F+GEL+ G F+ KMDHL CFLPGTLALG +GLP
Sbjct: 487 YVEAIEGVRTHLLRHSEPSKLTFVGELAHG--RFSAKMDHLVCFLPGTLALGVYHGLPAS 544
Query: 384 HMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTD--DMYTKSADAHSLLRPEFIESL 441
HM +A+EL+ TCY T L+PEI HFNL D+ K AD H+LLRPE +ESL
Sbjct: 545 HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESL 604
Query: 442 WYMYQITGNTTYQEWGWQIFQGFEKYAKVPN-GYSSLTNVKS-ENPIPRDMMESFFLSET 499
+Y+Y++TG+ YQ+WGW+I Q F ++ +VP+ GYSS+ NV+ + P PRD MESFFL ET
Sbjct: 605 FYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGET 664
Query: 500 XXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
SDD L+ L+ YV N+EAHPLPI
Sbjct: 665 LKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AL807752-35|CAI12781.1| 699|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 699
Score = 512 bits (1264), Expect = e-145
Identities = 247/451 (54%), Positives = 318/451 (70%), Gaps = 7/451 (1%)
Query: 85 NDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASDWFSLGLTIVDSLDTAYIMGLTDV 144
N RQ+ +++ F HAW+GY++ AWGHD LKPVS S+WF LGLT++D+LDT +I+GL
Sbjct: 247 NYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKE 306
Query: 145 FEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAF 204
FEE ++W+ ++L F K+ DVN FE TIRILGGLL+ ++ + D LFL KA D G+RLM AF
Sbjct: 307 FEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAF 366
Query: 205 SSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSE 264
+PS IPYSDVN+G AH P W+ ST AEVT++QLEFR+LSR +G+ F+EA V++
Sbjct: 367 RTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQ 426
Query: 265 KIHQLP-KKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLDD 323
IH L KK GLVP+FIN ++G F TLGAR DSYYEYLLKQW+Q GK LL+D
Sbjct: 427 HIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLED 486
Query: 324 YLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDW 383
Y+ IEGVR L + S P+K F+GEL+ G F+ KMDHL CFLPGTLALG +GLP
Sbjct: 487 YVEAIEGVRTHLLRHSEPSKLTFVGELAHG--RFSAKMDHLVCFLPGTLALGVYHGLPAS 544
Query: 384 HMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTD--DMYTKSADAHSLLRPEFIESL 441
HM +A+EL+ TCY T L+PEI HFNL D+ K AD H+LLRPE +ESL
Sbjct: 545 HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESL 604
Query: 442 WYMYQITGNTTYQEWGWQIFQGFEKYAKVPN-GYSSLTNVKS-ENPIPRDMMESFFLSET 499
+Y+Y++TG+ YQ+WGW+I Q F ++ +VP+ GYSS+ NV+ + P PRD MESFFL ET
Sbjct: 605 FYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGET 664
Query: 500 XXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
SDD L+ L+ YV N+EAHPLPI
Sbjct: 665 LKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AF148509-1|AAF03215.1| 699|Homo sapiens alpha 1,2-mannosidase
protein.
Length = 699
Score = 512 bits (1264), Expect = e-145
Identities = 247/451 (54%), Positives = 318/451 (70%), Gaps = 7/451 (1%)
Query: 85 NDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASDWFSLGLTIVDSLDTAYIMGLTDV 144
N RQ+ +++ F HAW+GY++ AWGHD LKPVS S+WF LGLT++D+LDT +I+GL
Sbjct: 247 NYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKE 306
Query: 145 FEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAF 204
FEE ++W+ ++L F K+ DVN FE TIRILGGLL+ ++ + D LFL KA D G+RLM AF
Sbjct: 307 FEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAF 366
Query: 205 SSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSE 264
+PS IPYSDVN+G AH P W+ ST AEVT++QLEFR+LSR +G+ F+EA V++
Sbjct: 367 RTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQ 426
Query: 265 KIHQLP-KKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLDD 323
IH L KK GLVP+FIN ++G F TLGAR DSYYEYLLKQW+Q GK LL+D
Sbjct: 427 HIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLED 486
Query: 324 YLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDW 383
Y+ IEGVR L + S P+K F+GEL+ G F+ KMDHL CFLPGTLALG +GLP
Sbjct: 487 YVEAIEGVRTHLLRHSEPSKLTFVGELAHG--RFSAKMDHLVCFLPGTLALGVYHGLPAS 544
Query: 384 HMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTD--DMYTKSADAHSLLRPEFIESL 441
HM +A+EL+ TCY T L+PEI HFNL D+ K AD H+LLRPE +ESL
Sbjct: 545 HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESL 604
Query: 442 WYMYQITGNTTYQEWGWQIFQGFEKYAKVPN-GYSSLTNVKS-ENPIPRDMMESFFLSET 499
+Y+Y++TG+ YQ+WGW+I Q F ++ +VP+ GYSS+ NV+ + P PRD MESFFL ET
Sbjct: 605 FYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGET 664
Query: 500 XXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
SDD L+ L+ YV N+EAHPLPI
Sbjct: 665 LKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AF145732-1|AAD45504.1| 663|Homo sapiens endoplasmic reticulum
alpha-mannosidase I protein.
Length = 663
Score = 512 bits (1264), Expect = e-145
Identities = 247/451 (54%), Positives = 318/451 (70%), Gaps = 7/451 (1%)
Query: 85 NDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASDWFSLGLTIVDSLDTAYIMGLTDV 144
N RQ+ +++ F HAW+GY++ AWGHD LKPVS S+WF LGLT++D+LDT +I+GL
Sbjct: 211 NYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWILGLRKE 270
Query: 145 FEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAF 204
FEE ++W+ ++L F K+ DVN FE TIRILGGLL+ ++ + D LFL KA D G+RLM AF
Sbjct: 271 FEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAF 330
Query: 205 SSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSE 264
+PS IPYSDVN+G AH P W+ ST AEVT++QLEFR+LSR +G+ F+EA V++
Sbjct: 331 RTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQ 390
Query: 265 KIHQLP-KKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLDD 323
IH L KK GLVP+FIN ++G F TLGAR DSYYEYLLKQW+Q GK LL+D
Sbjct: 391 HIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLED 450
Query: 324 YLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDW 383
Y+ IEGVR L + S P+K F+GEL+ G F+ KMDHL CFLPGTLALG +GLP
Sbjct: 451 YVEAIEGVRTHLLRHSEPSKLTFVGELAHG--RFSAKMDHLVCFLPGTLALGVYHGLPAS 508
Query: 384 HMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTD--DMYTKSADAHSLLRPEFIESL 441
HM +A+EL+ TCY T L+PEI HFNL D+ K AD H+LLRPE +ESL
Sbjct: 509 HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESL 568
Query: 442 WYMYQITGNTTYQEWGWQIFQGFEKYAKVPN-GYSSLTNVKS-ENPIPRDMMESFFLSET 499
+Y+Y++TG+ YQ+WGW+I Q F ++ +VP+ GYSS+ NV+ + P PRD MESFFL ET
Sbjct: 569 FYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGET 628
Query: 500 XXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
SDD L+ L+ YV N+EAHPLPI
Sbjct: 629 LKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 659
>BC063300-1|AAH63300.1| 641|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 641
Score = 303 bits (745), Expect = 7e-82
Identities = 162/455 (35%), Positives = 259/455 (56%), Gaps = 17/455 (3%)
Query: 86 DRQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS---LGLTIVDSLDTAYIMG 140
+++ + E +HAW Y+ + WGH+ L+P++ G + + F +G TIVD+LDT YIMG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 141 LTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRL 200
L D F +G++WI++ L F+ N +V+ FEV IR +GGLL +Y + +++F KA+ L ++L
Sbjct: 239 LHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKL 298
Query: 201 MAAFSSPSGIPYSDVNLGARTAHAPEWSH--YSTTAEVTTVQLEFRQLSRASGNPIFEEA 258
+ AF++P+GIP++ VNL + W+ S AE T+ +EF LS +G+ + +
Sbjct: 299 LPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKK 358
Query: 259 AAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTIN 318
+ + + ++ + +GL P ++NP TG + + T ++G GDS+YEYLLK WL + KT +
Sbjct: 359 VMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHT-SVGGLGDSFYEYLLKAWLMSDKTDH 417
Query: 319 YLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLN 378
Y IE + + L K+S FIGE G KM HL CF G ALG
Sbjct: 418 EARKMYDDAIEAIEKHLIKKSR-GGLTFIGEWKNGH--LEKKMGHLACFAGGMFALGADG 474
Query: 379 GLPD---WHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRP 435
D ++ + E+ TC+ +Y L PE F + + + A+ + +LRP
Sbjct: 475 SRADKAGHYLELGAEIARTCHESYDRTALKLGPE--SFKFDGAVEAVAVRQAEKYYILRP 532
Query: 436 EFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFF 495
E IE+ WY+++ T + Y++WGW+ EKY +V G+S + +V S P D+ +SFF
Sbjct: 533 EVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFF 592
Query: 496 LSETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
L+ET S D L+ L+ +V N+EAHPLP+
Sbjct: 593 LAETLKYLYLLFSGDD-LLPLDHWVFNTEAHPLPV 626
>AL358072-1|CAH71079.1| 641|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 641
Score = 303 bits (745), Expect = 7e-82
Identities = 162/455 (35%), Positives = 259/455 (56%), Gaps = 17/455 (3%)
Query: 86 DRQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS---LGLTIVDSLDTAYIMG 140
+++ + E +HAW Y+ + WGH+ L+P++ G + + F +G TIVD+LDT YIMG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 141 LTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRL 200
L D F +G++WI++ L F+ N +V+ FEV IR +GGLL +Y + +++F KA+ L ++L
Sbjct: 239 LHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKL 298
Query: 201 MAAFSSPSGIPYSDVNLGARTAHAPEWSH--YSTTAEVTTVQLEFRQLSRASGNPIFEEA 258
+ AF++P+GIP++ VNL + W+ S AE T+ +EF LS +G+ + +
Sbjct: 299 LPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKK 358
Query: 259 AAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTIN 318
+ + + ++ + +GL P ++NP TG + + T ++G GDS+YEYLLK WL + KT +
Sbjct: 359 VMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHT-SVGGLGDSFYEYLLKAWLMSDKTDH 417
Query: 319 YLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLN 378
Y IE + + L K+S FIGE G KM HL CF G ALG
Sbjct: 418 EARKMYDDAIEAIEKHLIKKSR-GGLTFIGEWKNGH--LEKKMGHLACFAGGMFALGADG 474
Query: 379 GLPD---WHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRP 435
D ++ + E+ TC+ +Y L PE F + + + A+ + +LRP
Sbjct: 475 SRADKAGHYLELGAEIARTCHESYDRTALKLGPE--SFKFDGAVEAVAVRQAEKYYILRP 532
Query: 436 EFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFF 495
E IE+ WY+++ T + Y++WGW+ EKY +V G+S + +V S P D+ +SFF
Sbjct: 533 EVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFF 592
Query: 496 LSETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
L+ET S D L+ L+ +V N+EAHPLP+
Sbjct: 593 LAETLKYLYLLFSGDD-LLPLDHWVFNTEAHPLPV 626
>AL157902-1|CAI22315.1| 641|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 641
Score = 303 bits (745), Expect = 7e-82
Identities = 162/455 (35%), Positives = 259/455 (56%), Gaps = 17/455 (3%)
Query: 86 DRQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS---LGLTIVDSLDTAYIMG 140
+++ + E +HAW Y+ + WGH+ L+P++ G + + F +G TIVD+LDT YIMG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 141 LTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRL 200
L D F +G++WI++ L F+ N +V+ FEV IR +GGLL +Y + +++F KA+ L ++L
Sbjct: 239 LHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKL 298
Query: 201 MAAFSSPSGIPYSDVNLGARTAHAPEWSH--YSTTAEVTTVQLEFRQLSRASGNPIFEEA 258
+ AF++P+GIP++ VNL + W+ S AE T+ +EF LS +G+ + +
Sbjct: 299 LPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKK 358
Query: 259 AAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTIN 318
+ + + ++ + +GL P ++NP TG + + T ++G GDS+YEYLLK WL + KT +
Sbjct: 359 VMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHT-SVGGLGDSFYEYLLKAWLMSDKTDH 417
Query: 319 YLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLN 378
Y IE + + L K+S FIGE G KM HL CF G ALG
Sbjct: 418 EARKMYDDAIEAIEKHLIKKSR-GGLTFIGEWKNGH--LEKKMGHLACFAGGMFALGADG 474
Query: 379 GLPD---WHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRP 435
D ++ + E+ TC+ +Y L PE F + + + A+ + +LRP
Sbjct: 475 SRADKAGHYLELGAEIARTCHESYDRTALKLGPE--SFKFDGAVEAVAVRQAEKYYILRP 532
Query: 436 EFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFF 495
E IE+ WY+++ T + Y++WGW+ EKY +V G+S + +V S P D+ +SFF
Sbjct: 533 EVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFF 592
Query: 496 LSETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
L+ET S D L+ L+ +V N+EAHPLP+
Sbjct: 593 LAETLKYLYLLFSGDD-LLPLDHWVFNTEAHPLPV 626
>AF027156-1|AAC26169.1| 641|Homo sapiens alpha 1,2-mannosidase IB
protein.
Length = 641
Score = 303 bits (745), Expect = 7e-82
Identities = 162/455 (35%), Positives = 259/455 (56%), Gaps = 17/455 (3%)
Query: 86 DRQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS---LGLTIVDSLDTAYIMG 140
+++ + E +HAW Y+ + WGH+ L+P++ G + + F +G TIVD+LDT YIMG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 141 LTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRL 200
L D F +G++WI++ L F+ N +V+ FEV IR +GGLL +Y + +++F KA+ L ++L
Sbjct: 239 LHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKL 298
Query: 201 MAAFSSPSGIPYSDVNLGARTAHAPEWSH--YSTTAEVTTVQLEFRQLSRASGNPIFEEA 258
+ AF++P+GIP++ VNL + W+ S AE T+ +EF LS +G+ + +
Sbjct: 299 LPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKK 358
Query: 259 AAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTIN 318
+ + + ++ + +GL P ++NP TG + + T ++G GDS+YEYLLK WL + KT +
Sbjct: 359 VMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHT-SVGGLGDSFYEYLLKAWLMSDKTDH 417
Query: 319 YLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLN 378
Y IE + + L K+S FIGE G KM HL CF G ALG
Sbjct: 418 EARKMYDDAIEAIEKHLIKKSR-GGLTFIGEWKNGH--LEKKMGHLACFAGGMFALGADG 474
Query: 379 GLPD---WHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRP 435
D ++ + E+ TC+ +Y L PE F + + + A+ + +LRP
Sbjct: 475 SRADKAGHYLELGAEIARTCHESYDRTALKLGPE--SFKFDGAVEAVAVRQAEKYYILRP 532
Query: 436 EFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFF 495
E IE+ WY+++ T + Y++WGW+ EKY +V G+S + +V S P D+ +SFF
Sbjct: 533 EVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFF 592
Query: 496 LSETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
L+ET S D L+ L+ +V N+EAHPLP+
Sbjct: 593 LAETLKYLYLLFSGDD-LLPLDHWVFNTEAHPLPV 626
>AL078600-1|CAB75695.2| 653|Homo sapiens mannosidase, alpha, class
1A, member 1 protein.
Length = 653
Score = 301 bits (738), Expect = 5e-81
Identities = 165/454 (36%), Positives = 256/454 (56%), Gaps = 16/454 (3%)
Query: 86 DRQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS--LGLTIVDSLDTAYIMGL 141
+++ + E +HAW YK +AWG + LKP+S G +S F G TIVD+LDT +IM +
Sbjct: 194 EKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEM 253
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLM 201
FEE K W++E L F N +++ FEV IR +GGLL+ +Y + +++F KA++LG +L+
Sbjct: 254 KHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLL 313
Query: 202 AAFSSPSGIPYSDVNLGARTAHAPEWSH--YSTTAEVTTVQLEFRQLSRASGNPIFEEAA 259
AF +PSGIP++ +N+ + W+ S AE T+ LEF LS SGNPIF E
Sbjct: 314 PAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAEKV 373
Query: 260 AAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINY 319
+ +++L K GL P ++NP++G + H +++G GDS+YEYLLK WL + KT
Sbjct: 374 MNIRTVLNKLEKPQGLYPNYLNPSSGQWGQH-HVSVGGLGDSFYEYLLKAWLMSDKTDLE 432
Query: 320 LLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALG---H 376
Y ++ + L ++SS + +I E G KM HLTCF G ALG
Sbjct: 433 AKKMYFDAVQAIETHLIRKSS-SGLTYIAEWKGG--LLEHKMGHLTCFAGGMFALGADAA 489
Query: 377 LNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRPE 436
G+ ++ + E+ TC+ +Y L PE F+ + + T+ + + +LRPE
Sbjct: 490 PEGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFD--GGVEAIATRQNEKYYILRPE 547
Query: 437 FIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFFL 496
+E+ YM+++T + Y++W W+ + E + +V GYS L +V + D+ +SFFL
Sbjct: 548 VMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFL 607
Query: 497 SETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
+ET SDD L+ L ++ NSEAH LPI
Sbjct: 608 AETLKYLYLIFSDDD-LLPLEHWIFNSEAHLLPI 640
>AL022722-2|CAI20315.1| 653|Homo sapiens mannosidase, alpha, class
1A, member 1 protein.
Length = 653
Score = 301 bits (738), Expect = 5e-81
Identities = 165/454 (36%), Positives = 256/454 (56%), Gaps = 16/454 (3%)
Query: 86 DRQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS--LGLTIVDSLDTAYIMGL 141
+++ + E +HAW YK +AWG + LKP+S G +S F G TIVD+LDT +IM +
Sbjct: 194 EKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEM 253
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLM 201
FEE K W++E L F N +++ FEV IR +GGLL+ +Y + +++F KA++LG +L+
Sbjct: 254 KHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLL 313
Query: 202 AAFSSPSGIPYSDVNLGARTAHAPEWSH--YSTTAEVTTVQLEFRQLSRASGNPIFEEAA 259
AF +PSGIP++ +N+ + W+ S AE T+ LEF LS SGNPIF E
Sbjct: 314 PAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAEKV 373
Query: 260 AAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINY 319
+ +++L K GL P ++NP++G + H +++G GDS+YEYLLK WL + KT
Sbjct: 374 MNIRTVLNKLEKPQGLYPNYLNPSSGQWGQH-HVSVGGLGDSFYEYLLKAWLMSDKTDLE 432
Query: 320 LLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALG---H 376
Y ++ + L ++SS + +I E G KM HLTCF G ALG
Sbjct: 433 AKKMYFDAVQAIETHLIRKSS-SGLTYIAEWKGG--LLEHKMGHLTCFAGGMFALGADAA 489
Query: 377 LNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRPE 436
G+ ++ + E+ TC+ +Y L PE F+ + + T+ + + +LRPE
Sbjct: 490 PEGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFD--GGVEAIATRQNEKYYILRPE 547
Query: 437 FIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFFL 496
+E+ YM+++T + Y++W W+ + E + +V GYS L +V + D+ +SFFL
Sbjct: 548 VMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFL 607
Query: 497 SETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
+ET SDD L+ L ++ NSEAH LPI
Sbjct: 608 AETLKYLYLIFSDDD-LLPLEHWIFNSEAHLLPI 640
>X74837-1|CAA52831.1| 625|Homo sapiens Man9-mannosidase protein.
Length = 625
Score = 300 bits (737), Expect = 7e-81
Identities = 165/454 (36%), Positives = 256/454 (56%), Gaps = 16/454 (3%)
Query: 86 DRQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS--LGLTIVDSLDTAYIMGL 141
+++ + E +HAW YK +AWG + LKP+S G +S F G TIVD+LDT +IM +
Sbjct: 166 EKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEM 225
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLM 201
FEE K W++E L F N +++ FEV IR +GGLL+ +Y + +++F KA++LG +L+
Sbjct: 226 KHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLL 285
Query: 202 AAFSSPSGIPYSDVNLGARTAHAPEWSH--YSTTAEVTTVQLEFRQLSRASGNPIFEEAA 259
AF +PSGIP++ +N+ + W+ S AE T+ LEF LS SGNPIF E
Sbjct: 286 PAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAEKV 345
Query: 260 AAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINY 319
+ +++L K GL P ++NP++G + H +++G GDS+YEYLLK WL + KT
Sbjct: 346 MNIRTVLNKLEKPQGLYPNYLNPSSGQWGQH-HVSVGGLGDSFYEYLLKAWLMSDKTDLE 404
Query: 320 LLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALG---H 376
Y ++ + L ++SS + +I E G KM HLTCF G ALG
Sbjct: 405 AKKMYFDAVQAIETHLIRKSS-SGLTYIAEWKRG--LLEHKMGHLTCFAGGMFALGADAA 461
Query: 377 LNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRPE 436
G+ ++ + E+ TC+ +Y L PE F+ + + T+ + + +LRPE
Sbjct: 462 PEGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFD--GGVEAIATRQNEKYYILRPE 519
Query: 437 FIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFFL 496
+E+ YM+++T + Y++W W+ + E + +V GYS L +V + D+ +SFFL
Sbjct: 520 VMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFL 579
Query: 497 SETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
+ET SDD L+ L ++ NSEAH LPI
Sbjct: 580 AETLKYLYLIFSDDD-LLPLEHWIFNSEAHLLPI 612
>AL031280-2|CAI19714.1| 630|Homo sapiens mannosidase, alpha, class
1C, member 1 protein.
Length = 630
Score = 287 bits (705), Expect = 5e-77
Identities = 156/452 (34%), Positives = 253/452 (55%), Gaps = 14/452 (3%)
Query: 87 RQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS--LGLTIVDSLDTAYIMGLT 142
++ + E + AW+ YK +A G + L+P++ G + F G T++DSLDT Y+M L
Sbjct: 174 QREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELK 233
Query: 143 DVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMA 202
+ F+E K W+ E + + + FEV IR +GGLL+ Y T +++F KAI LG++L+
Sbjct: 234 EEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLP 293
Query: 203 AFSSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAV 262
AF++P+GIP V+ + S AE ++ LEF L+ SGN +F E +
Sbjct: 294 AFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNI 353
Query: 263 SEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLD 322
+ + ++ K GL P F++P +G+++ H +++G GDS+YEYL+K WL +GKT +
Sbjct: 354 RKVLRKIEKPFGLYPNFLSPVSGNWVQH-HVSVGGLGDSFYEYLIKSWLMSGKTDMEAKN 412
Query: 323 DYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPD 382
Y +E + +L SP +I E G + KM HL CF G +ALG + +
Sbjct: 413 MYYEALEAIETYLL-NVSPGGLTYIAEWRGG--ILDHKMGHLACFSGGMIALGAEDAKEE 469
Query: 383 ---WHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRPEFIE 439
+ +A ++ TC+ +YA T L PE FN S + + T+ ++++ +LRPE +E
Sbjct: 470 KRAHYRELAAQITKTCHESYARSDTKLGPEAFWFN--SGREAVATQLSESYYILRPEVVE 527
Query: 440 SLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFFLSET 499
S Y+++ T N Y+EWGW++ EKY + G+S + +V S P + +SFFL+ET
Sbjct: 528 SYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAET 587
Query: 500 XXXXXXXXSDDRFLIDLNKYVVNSEAHPLPIH 531
S+D L+ L +V N+EAHPLP++
Sbjct: 588 LKYLYLLFSEDD-LLSLEDWVFNTEAHPLPVN 618
>AF261655-1|AAF97058.1| 630|Homo sapiens 1,2-alpha-mannosidase IC
protein.
Length = 630
Score = 287 bits (705), Expect = 5e-77
Identities = 156/452 (34%), Positives = 253/452 (55%), Gaps = 14/452 (3%)
Query: 87 RQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS--LGLTIVDSLDTAYIMGLT 142
++ + E + AW+ YK +A G + L+P++ G + F G T++DSLDT Y+M L
Sbjct: 174 QREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELK 233
Query: 143 DVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMA 202
+ F+E K W+ E + + + FEV IR +GGLL+ Y T +++F KAI LG++L+
Sbjct: 234 EEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLP 293
Query: 203 AFSSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAV 262
AF++P+GIP V+ + S AE ++ LEF L+ SGN +F E +
Sbjct: 294 AFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNI 353
Query: 263 SEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLD 322
+ + ++ K GL P F++P +G+++ H +++G GDS+YEYL+K WL +GKT +
Sbjct: 354 RKVLRKIEKPFGLYPNFLSPVSGNWVQH-HVSVGGLGDSFYEYLIKSWLMSGKTDMEAKN 412
Query: 323 DYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPD 382
Y +E + +L SP +I E G + KM HL CF G +ALG + +
Sbjct: 413 MYYEALEAIETYLL-NVSPGGLTYIAEWRGG--ILDHKMGHLACFSGGMIALGAEDAKEE 469
Query: 383 ---WHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRPEFIE 439
+ +A ++ TC+ +YA T L PE FN S + + T+ ++++ +LRPE +E
Sbjct: 470 KRAHYRELAAQITKTCHESYARSDTKLGPEAFWFN--SGREAVATQLSESYYILRPEVVE 527
Query: 440 SLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFFLSET 499
S Y+++ T N Y+EWGW++ EKY + G+S + +V S P + +SFFL+ET
Sbjct: 528 SYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAET 587
Query: 500 XXXXXXXXSDDRFLIDLNKYVVNSEAHPLPIH 531
S+D L+ L +V N+EAHPLP++
Sbjct: 588 LKYLYLLFSEDD-LLSLEDWVFNTEAHPLPVN 618
>AL031280-1|CAI19713.1| 450|Homo sapiens mannosidase, alpha, class
1C, member 1 protein.
Length = 450
Score = 285 bits (700), Expect = 2e-76
Identities = 155/441 (35%), Positives = 248/441 (56%), Gaps = 14/441 (3%)
Query: 98 AWRGYKEHAWGHDNLKPVS--GMASDWFS--LGLTIVDSLDTAYIMGLTDVFEEGKQWIK 153
AW+ YK +A G + L+P++ G + F G T++DSLDT Y+M L + F+E K W+
Sbjct: 5 AWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELKEEFQEAKAWVG 64
Query: 154 EELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAFSSPSGIPYS 213
E + + + FEV IR +GGLL+ Y T +++F KAI LG++L+ AF++P+GIP
Sbjct: 65 ESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFNTPTGIPKG 124
Query: 214 DVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSEKIHQLPKKH 273
V+ + S AE ++ LEF L+ SGN +F E + + + ++ K
Sbjct: 125 VVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNIRKVLRKIEKPF 184
Query: 274 GLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLDDYLTGIEGVRE 333
GL P F++P +G+++ H +++G GDS+YEYL+K WL +GKT + Y +E +
Sbjct: 185 GLYPNFLSPVSGNWVQH-HVSVGGLGDSFYEYLIKSWLMSGKTDMEAKNMYYEALEAIET 243
Query: 334 FLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPD---WHMTMAEE 390
+L SP +I E G + KM HL CF G +ALG + + + +A +
Sbjct: 244 YLL-NVSPGGLTYIAEWRGG--ILDHKMGHLACFSGGMIALGAEDAKEEKRAHYRELAAQ 300
Query: 391 LLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRPEFIESLWYMYQITGN 450
+ TC+ +YA T L PE FN S + + T+ ++++ +LRPE +ES Y+++ T N
Sbjct: 301 ITKTCHESYARSDTKLGPEAFWFN--SGREAVATQLSESYYILRPEVVESYMYLWRQTHN 358
Query: 451 TTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFFLSETXXXXXXXXSDD 510
Y+EWGW++ EKY + G+S + +V S P + +SFFL+ET S+D
Sbjct: 359 PIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAETLKYLYLLFSED 418
Query: 511 RFLIDLNKYVVNSEAHPLPIH 531
L+ L +V N+EAHPLP++
Sbjct: 419 D-LLSLEDWVFNTEAHPLPVN 438
>AB209275-1|BAD92512.1| 482|Homo sapiens mannosidase, alpha, class
1C, member 1 variant protein.
Length = 482
Score = 267 bits (654), Expect = 8e-71
Identities = 144/420 (34%), Positives = 235/420 (55%), Gaps = 13/420 (3%)
Query: 87 RQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS--LGLTIVDSLDTAYIMGLT 142
++ + E + AW+ YK +A G + L+P++ G + F G T++DSLDT Y+M L
Sbjct: 66 QREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELK 125
Query: 143 DVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMA 202
+ F+E K W+ E + + + FEV IR +GGLL+ Y T +++F KAI LG++L+
Sbjct: 126 EEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLP 185
Query: 203 AFSSPSGIPYSDVNLGARTAHAPEWSHYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAV 262
AF++P+GIP V+ + S AE ++ LEF L+ SGN +F E +
Sbjct: 186 AFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNI 245
Query: 263 SEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLD 322
+ + ++ K GL P F++P +G+++ H +++G GDS+YEYL+K WL +GKT +
Sbjct: 246 RKVLRKIEKPFGLYPNFLSPVSGNWVQH-HVSVGGLGDSFYEYLIKSWLMSGKTDMEAKN 304
Query: 323 DYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPD 382
Y +E + +L SP +I E G + KM HL CF G +ALG + +
Sbjct: 305 MYYEALEAIETYLL-NVSPGGLTYIAEWRGG--ILDHKMGHLACFSGGMIALGAEDAKEE 361
Query: 383 ---WHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRPEFIE 439
+ +A ++ TC+ +YA T L PE FN S + + T+ ++++ +LRPE +E
Sbjct: 362 KRAHYRELAAQITKTCHESYARSDTKLGPEAFWFN--SGREAVATQLSESYYILRPEVVE 419
Query: 440 SLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFFLSET 499
S Y+++ T N Y+EWGW++ EKY + G+S + +V S P + +SFFL+ET
Sbjct: 420 SYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAET 479
>AL929554-1|CAH72871.2| 329|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 329
Score = 255 bits (624), Expect = 3e-67
Identities = 125/233 (53%), Positives = 160/233 (68%), Gaps = 5/233 (2%)
Query: 241 LEFRQLSRASGNPIFEEAAAAVSEKIHQLP-KKHGLVPIFINPNTGHFLPHATITLGARG 299
LEFR+LSR +G+ F+EA V++ IH L KK GLVP+FIN ++G F TLGAR
Sbjct: 1 LEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARA 60
Query: 300 DSYYEYLLKQWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNP 359
DSYYEYLLKQW+Q GK LL+DY+ IEGVR L + S P+K F+GEL+ G F+
Sbjct: 61 DSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG--RFSA 118
Query: 360 KMDHLTCFLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTT 419
KMDHL CFLPGTLALG +GLP HM +A+EL+ TCY T L+PEI HFNL
Sbjct: 119 KMDHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQP 178
Query: 420 D--DMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKV 470
D+ K AD H+LLRPE +ESL+Y+Y++TG+ YQ+WGW+I Q F ++ +V
Sbjct: 179 GRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRV 231
>AL358072-2|CAH71080.1| 343|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 343
Score = 205 bits (501), Expect = 3e-52
Identities = 112/334 (33%), Positives = 183/334 (54%), Gaps = 11/334 (3%)
Query: 171 IRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAFSSPSGIPYSDVNLGARTAHAPEWSHY 230
IR +GGLL +Y + +++F KA+ L ++L+ AF++P+GIP++ VNL + W+
Sbjct: 1 IRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASA 60
Query: 231 STT--AEVTTVQLEFRQLSRASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFL 288
++ AE T+ +EF LS +G+ + + + + + ++ + +GL P ++NP TG +
Sbjct: 61 GSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWG 120
Query: 289 PHATITLGARGDSYYEYLLKQWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIG 348
+ T ++G GDS+YEYLLK WL + KT + Y IE + + L K+S FIG
Sbjct: 121 QYHT-SVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLT-FIG 178
Query: 349 ELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPD---WHMTMAEELLYTCYLTYAAHPTF 405
E G KM HL CF G ALG D ++ + E+ TC+ +Y
Sbjct: 179 EWKNGH--LEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALK 236
Query: 406 LAPEITHFNLASTTDDMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFE 465
L PE F + + + A+ + +LRPE IE+ WY+++ T + Y++WGW+ E
Sbjct: 237 LGPE--SFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIE 294
Query: 466 KYAKVPNGYSSLTNVKSENPIPRDMMESFFLSET 499
KY +V G+S + +V S P D+ +SFFL+ET
Sbjct: 295 KYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAET 328
>AL157902-4|CAI22318.1| 343|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 343
Score = 205 bits (501), Expect = 3e-52
Identities = 112/334 (33%), Positives = 183/334 (54%), Gaps = 11/334 (3%)
Query: 171 IRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAFSSPSGIPYSDVNLGARTAHAPEWSHY 230
IR +GGLL +Y + +++F KA+ L ++L+ AF++P+GIP++ VNL + W+
Sbjct: 1 IRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASA 60
Query: 231 STT--AEVTTVQLEFRQLSRASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFL 288
++ AE T+ +EF LS +G+ + + + + + ++ + +GL P ++NP TG +
Sbjct: 61 GSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWG 120
Query: 289 PHATITLGARGDSYYEYLLKQWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIG 348
+ T ++G GDS+YEYLLK WL + KT + Y IE + + L K+S FIG
Sbjct: 121 QYHT-SVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLT-FIG 178
Query: 349 ELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPD---WHMTMAEELLYTCYLTYAAHPTF 405
E G KM HL CF G ALG D ++ + E+ TC+ +Y
Sbjct: 179 EWKNGH--LEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALK 236
Query: 406 LAPEITHFNLASTTDDMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFE 465
L PE F + + + A+ + +LRPE IE+ WY+++ T + Y++WGW+ E
Sbjct: 237 LGPE--SFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIE 294
Query: 466 KYAKVPNGYSSLTNVKSENPIPRDMMESFFLSET 499
KY +V G+S + +V S P D+ +SFFL+ET
Sbjct: 295 KYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAET 328
>AK074559-1|BAC11060.1| 178|Homo sapiens .2.1.113). protein.
Length = 178
Score = 194 bits (474), Expect = 5e-49
Identities = 94/174 (54%), Positives = 119/174 (68%), Gaps = 4/174 (2%)
Query: 361 MDHLTCFLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTD 420
MDHL CFLPGTLALG +GLP HM +A+EL+ TCY T L+PEI HFNL
Sbjct: 1 MDHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPG 60
Query: 421 --DMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPN-GYSSL 477
D+ K AD H+LLRPE +ESL+Y+Y++TG+ YQ+WGW+I Q F ++ +VP+ GYSS+
Sbjct: 61 RRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSI 120
Query: 478 TNVKS-ENPIPRDMMESFFLSETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
NV+ + P PRD MESFFL ET SDD L+ L+ YV N+EAHPLPI
Sbjct: 121 NNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 174
>AK023308-1|BAB14518.1| 618|Homo sapiens protein ( Homo sapiens
cDNA FLJ13246 fis, clone OVARC1000682, highly similar to
PROCESSING ALPHA-1,2-MANNOSIDASE (EC 3.2.1.-). ).
Length = 618
Score = 190 bits (464), Expect = 8e-48
Identities = 107/290 (36%), Positives = 165/290 (56%), Gaps = 9/290 (3%)
Query: 125 LGLTIVDSLDTAYIMGLTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFT 184
+G TIVD+LDT YIMGL D F +G++WI++ L F+ N +V+ FEV IR +GGLL +Y +
Sbjct: 13 MGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLS 72
Query: 185 QDQLFLDKAIDLGDRLMAAFSSPSGIPYSDVNLGARTAHAPEWSH--YSTTAEVTTVQLE 242
+++F KA+ L ++L+ AF++P+GIP++ VNL + W+ S AE T+ +E
Sbjct: 73 GEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHME 132
Query: 243 FRQLSRASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSY 302
F LS +G+ + + + + + ++ + +GL P ++NP TG + + T ++G GDS+
Sbjct: 133 FIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHT-SVGGLGDSF 191
Query: 303 YEYLLKQWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMD 362
YEYLLK WL + KT + Y IE + + L K+S FIGE G KM
Sbjct: 192 YEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSR-GGLTFIGEWKNGH--LEKKMG 248
Query: 363 HLTCFLPGTLALGHLNGLPD---WHMTMAEELLYTCYLTYAAHPTFLAPE 409
HL CF G ALG D ++ + E+ TC+ +Y L PE
Sbjct: 249 HLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPE 298
>AB209276-1|BAD92513.1| 185|Homo sapiens alpha 1,2-mannosidase
variant protein.
Length = 185
Score = 173 bits (421), Expect = 1e-42
Identities = 85/165 (51%), Positives = 110/165 (66%), Gaps = 4/165 (2%)
Query: 370 GTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTD--DMYTKSA 427
GTLALG +GLP HM +A+EL+ TCY T L+PEI HFNL D+ K A
Sbjct: 17 GTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPA 76
Query: 428 DAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPN-GYSSLTNVKS-ENP 485
D H+LLRPE +ESL+Y+Y++TG+ YQ+WGW+I Q F ++ +VP+ GYSS+ N + + P
Sbjct: 77 DRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNAQDPQKP 136
Query: 486 IPRDMMESFFLSETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
PRD MESFFL ET SDD L+ L+ YV N+EAHPLPI
Sbjct: 137 EPRDKMESFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 181
>AL096819-3|CAI21741.1| 932|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 3 protein.
Length = 932
Score = 160 bits (389), Expect = 1e-38
Identities = 152/492 (30%), Positives = 232/492 (47%), Gaps = 65/492 (13%)
Query: 73 TVYERPVFTGPKNDRQRALVESFRHAWRGYKEHAWGHDNLKPVS------------GMAS 120
T P+ K ++E F HA+ Y EHA+ D L P++ G
Sbjct: 38 TAGAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVD 97
Query: 121 DWFS-LGLTIVDSLDTAYIMGLTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLT 179
D LT++DSLDT ++ T FE+ + + ++ + V+ FE IR+LGGLL
Sbjct: 98 DALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLG 157
Query: 180 NH-------------YFTQDQLFLDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHA 224
H + D+L L A LG +L+ AF++ SG+PY +NL G R A
Sbjct: 158 GHSLAIMLKEKGEYMQWYNDEL-LQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEA 216
Query: 225 PEWSHYST-TAEVTTVQLEFRQLSRASGNPIFEE-AAAAVSEKIHQLPKKHGLVPIFINP 282
+ T TA T+ LEF LSR +G IFEE A A+ + + LV + IN
Sbjct: 217 RTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINI 276
Query: 283 NTGHFLPHATITLGARGDSYYEYLLKQWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPN 342
+TG ++ +GA DSYYEYLLK ++ G + L+ + T + + ++ S P
Sbjct: 277 HTGDWV-RKDSGVGAGIDSYYEYLLKAYVLLGD--DSFLERFNTHYDAIMRYI---SQPP 330
Query: 343 KRLFIGELSAGSEAFNPK--MDHLTCFLPGTLAL-GHLNGLPDWHMTMAEELLYTCYLTY 399
L ++ N + MD L F PG L G + + H E+LY +
Sbjct: 331 LLL---DVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETH-----EMLYQVIKKH 382
Query: 400 AAHPTFLAPEITHFNLASTTDDMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQ 459
FL PE A TTD + A LRPEF ES +++Y+ TG+ Y E G
Sbjct: 383 ----NFL-PE------AFTTD---FRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKT 428
Query: 460 IFQGFEKYAKVPNGYSSLTNVKSENPIPRDMMESFFLSETXXXXXXXXSD-DRFLIDLNK 518
+ + KYA+VP G++++ +V++ + D M+SFFL+E +D + + D+
Sbjct: 429 LIENLNKYARVPCGFAAMKDVRTGS--HEDRMDSFFLAEMFKYLYLLFADKEDIIFDIED 486
Query: 519 YVVNSEAHPLPI 530
Y+ +EAH LP+
Sbjct: 487 YIFTTEAHLLPL 498
>AF288393-1|AAG60613.1| 889|Homo sapiens C1orf22 protein.
Length = 889
Score = 159 bits (387), Expect = 2e-38
Identities = 149/474 (31%), Positives = 228/474 (48%), Gaps = 65/474 (13%)
Query: 91 LVESFRHAWRGYKEHAWGHDNLKPVS------------GMASDWFS-LGLTIVDSLDTAY 137
++E F HA+ Y EHA+ D L P++ G D LT++DSLDT
Sbjct: 13 VLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLV 72
Query: 138 IMGLTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNH-------------YFT 184
++ T FE+ + + ++ + V+ FE IR+LGGLL H +
Sbjct: 73 VLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWY 132
Query: 185 QDQLFLDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWSHYST-TAEVTTVQL 241
D+L L A LG +L+ AF++ SG+PY +NL G R A + T TA T+ L
Sbjct: 133 NDEL-LQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLIL 191
Query: 242 EFRQLSRASGNPIFEE-AAAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGD 300
EF LSR +G IFEE A A+ + + LV + IN +TG ++ +GA D
Sbjct: 192 EFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWV-RKDSGVGAGID 250
Query: 301 SYYEYLLKQWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPK 360
SYYEYLLK ++ G + L+ + T + + ++ S P L ++ N +
Sbjct: 251 SYYEYLLKAYVLLGD--DSFLERFNTHYDAIMRYI---SQPPLLL---DVHIHKPMLNAR 302
Query: 361 --MDHLTCFLPGTLAL-GHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLAS 417
MD L F PG L G + + H E+LY + FL PE A
Sbjct: 303 TWMDALLAFFPGLQVLKGDIRPAIETH-----EMLYQVIKKH----NFL-PE------AF 346
Query: 418 TTDDMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSL 477
TTD + A LRPEF ES +++Y+ TG+ Y E G + + KYA+VP G++++
Sbjct: 347 TTD---FRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAM 403
Query: 478 TNVKSENPIPRDMMESFFLSETXXXXXXXXSD-DRFLIDLNKYVVNSEAHPLPI 530
+V++ + D M+SFFL+E +D + + D+ Y+ +EAH LP+
Sbjct: 404 KDVRTGS--HEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPL 455
>AF053626-1|AAC26201.1| 251|Homo sapiens alpha 1,2-mannosidase IB
protein.
Length = 251
Score = 154 bits (373), Expect = 9e-37
Identities = 86/240 (35%), Positives = 126/240 (52%), Gaps = 9/240 (3%)
Query: 294 TLGARGDSYYEYLLKQWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAG 353
++G GDS+YEYLLK WL + KT + Y IE + + L K+S FIGE G
Sbjct: 3 SVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLT-FIGEWKNG 61
Query: 354 SEAFNPKMDHLTCFLPGTLALGHLNGLPD---WHMTMAEELLYTCYLTYAAHPTFLAPEI 410
KM HL CF G ALG D ++ + E+ TC+ +Y L PE
Sbjct: 62 H--LEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPE- 118
Query: 411 THFNLASTTDDMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKV 470
F + + + A+ + +LRPE IE+ WY+++ T + Y++WGW+ EKY +V
Sbjct: 119 -SFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRV 177
Query: 471 PNGYSSLTNVKSENPIPRDMMESFFLSETXXXXXXXXSDDRFLIDLNKYVVNSEAHPLPI 530
G+S + +V S P D+ +SFFL+ET S D L+ L+ +V N+EAHPLP+
Sbjct: 178 NGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDD-LLPLDHWVFNTEAHPLPV 236
>D86967-1|BAA13203.2| 666|Homo sapiens KIAA0212 protein.
Length = 666
Score = 145 bits (352), Expect = 3e-34
Identities = 131/430 (30%), Positives = 203/430 (47%), Gaps = 47/430 (10%)
Query: 127 LTIVDSLDTAYIMGLTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQD 186
LT+VD+LDT IMG + F++ + + + F K+ V FE TIR+LG LL+ H D
Sbjct: 193 LTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITD 252
Query: 187 --QLFLDKAI------------DLGDRLMAAF-SSPSGIPYSDVNLGARTAHAPEWSHYS 231
Q F D I DL RL+ AF ++ +GIPY VNL +T P+ ++ +
Sbjct: 253 SKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNL--KTGVPPDTNNET 310
Query: 232 TTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSEKIHQLPKKH-GLVPIFINPNTGHFLPH 290
TA ++ +EF LSR G+ FE A + + L GL+ +N TGH++
Sbjct: 311 CTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGK 370
Query: 291 ATITLGARGDSYYEYLLKQWLQTGKTINYLLDDYLTGIEGVREFLAK-RSSPNK-----R 344
+ LGA DS+YEYLLK ++ G+ + L+ + + ++ +L + R + N+
Sbjct: 371 QS-GLGAGLDSFYEYLLKSYILFGEKED--LEMFNAAYQSIQNYLRRGREACNEGEGDPP 427
Query: 345 LFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPT 404
L++ + N +D L F PG L + + D Y + Y A
Sbjct: 428 LYVNVNMFSGQLMNTWIDSLQAFFPGLQVL--IGDVED--AICLHAFYYAIWKRYGA--- 480
Query: 405 FLAPEITHFNLASTTDDMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGF 464
PE ++ L + Y LRPE +ES + +YQ T N Y G I Q
Sbjct: 481 --LPERYNWQLQAPDVLFYP--------LRPELVESTYLLYQATKNPFYLHVGMDILQSL 530
Query: 465 EKYAKVPNGYSSLTNVKSENPIPRDMMESFFLSETXXXXXXXXSDDRFLIDL-NKYVVNS 523
EKY KV GY++L +V ++ D MESFFLSET +D + +Y+ +
Sbjct: 531 EKYTKVKCGYATLHHVIDKS--TEDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTT 588
Query: 524 EAHPLPIHKN 533
E H + + ++
Sbjct: 589 EGHIVSVDEH 598
>BC019088-1|AAH19088.1| 657|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 1 protein.
Length = 657
Score = 145 bits (352), Expect = 3e-34
Identities = 131/430 (30%), Positives = 203/430 (47%), Gaps = 47/430 (10%)
Query: 127 LTIVDSLDTAYIMGLTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQD 186
LT+VD+LDT IMG + F++ + + + F K+ V FE TIR+LG LL+ H D
Sbjct: 184 LTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITD 243
Query: 187 --QLFLDKAI------------DLGDRLMAAF-SSPSGIPYSDVNLGARTAHAPEWSHYS 231
Q F D I DL RL+ AF ++ +GIPY VNL +T P+ ++ +
Sbjct: 244 SKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNL--KTGVPPDTNNET 301
Query: 232 TTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSEKIHQLPKKH-GLVPIFINPNTGHFLPH 290
TA ++ +EF LSR G+ FE A + + L GL+ +N TGH++
Sbjct: 302 CTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGK 361
Query: 291 ATITLGARGDSYYEYLLKQWLQTGKTINYLLDDYLTGIEGVREFLAK-RSSPNK-----R 344
+ LGA DS+YEYLLK ++ G+ + L+ + + ++ +L + R + N+
Sbjct: 362 QS-GLGAGLDSFYEYLLKSYILFGEKED--LEMFNAAYQSIQNYLRRGREACNEGEGDPP 418
Query: 345 LFIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPT 404
L++ + N +D L F PG L + + D Y + Y A
Sbjct: 419 LYVNVNMFSGQLMNTWIDSLQAFFPGLQVL--IGDVED--AICLHAFYYAIWKRYGA--- 471
Query: 405 FLAPEITHFNLASTTDDMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGF 464
PE ++ L + Y LRPE +ES + +YQ T N Y G I Q
Sbjct: 472 --LPERYNWQLQAPDVLFYP--------LRPELVESTYLLYQATKNPFYLHVGMDILQSL 521
Query: 465 EKYAKVPNGYSSLTNVKSENPIPRDMMESFFLSETXXXXXXXXSDDRFLIDL-NKYVVNS 523
EKY KV GY++L +V ++ D MESFFLSET +D + +Y+ +
Sbjct: 522 EKYTKVKCGYATLHHVIDKS--TEDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTT 579
Query: 524 EAHPLPIHKN 533
E H + + ++
Sbjct: 580 EGHIVSVDEH 589
>AF053621-1|AAC26200.1| 358|Homo sapiens alpha 1,2-mannosidase IB
protein.
Length = 358
Score = 140 bits (339), Expect = 1e-32
Identities = 68/174 (39%), Positives = 112/174 (64%), Gaps = 7/174 (4%)
Query: 86 DRQRALVESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS---LGLTIVDSLDTAYIMG 140
+++ + E +HAW Y+ + WGH+ L+P++ G + + F +G TIVD+LDT YIMG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 141 LTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRL 200
L D F +G++WI++ L F+ N +V+ FEV IR +GGLL +Y + +++F KA+ L ++L
Sbjct: 239 LHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKL 298
Query: 201 MAAFSSPSGIPYSDVNLGARTAHAPEWSH--YSTTAEVTTVQLEFRQLSRASGN 252
+ AF++P+GIP++ VNL + W+ S AE T+ +EF LS +G+
Sbjct: 299 LPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGD 352
>CR457266-1|CAG33547.1| 578|Homo sapiens C20orf31 protein.
Length = 578
Score = 138 bits (334), Expect = 5e-32
Identities = 123/433 (28%), Positives = 203/433 (46%), Gaps = 47/433 (10%)
Query: 83 PKNDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASD-WFSLGLTIVDSLDTAYIMGL 141
P + R+R F HA+ Y E+A+ D L+P++ D W S LT++D+LDT I+G
Sbjct: 32 PAHYRERVKA-MFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGN 90
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQ------------DQLF 189
F+ + +++ + F + + + FE IR++GGLL+ H ++
Sbjct: 91 VSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPL 150
Query: 190 LDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWSHYSTTAEVTTVQLEFRQLS 247
L A + +L+ AF +P+G+PY VNL G P + TA + T +EF LS
Sbjct: 151 LRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETP----VTCTAGIGTFIVEFATLS 206
Query: 248 RASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLL 307
+G+P+FE+ A ++ + GLV I+ TG ++ +GA DSY+EYL+
Sbjct: 207 SLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQ-DAGIGAGVDSYFEYLV 265
Query: 308 K-QWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTC 366
K L K + + +Y I F + L++ ++ G+ + P L
Sbjct: 266 KGAILLQDKKLMAMFLEYNKAIRNYTRF------DDWYLWV-QMYKGTVSM-PVFQSLEA 317
Query: 367 FLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKS 426
+ PG +L + + + T YT + + P F +N+ YT
Sbjct: 318 YWPGLQSL--IGDIDNAMRTFLN--YYTVWKQFGGLPEF-------YNIPQG----YTVE 362
Query: 427 ADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPI 486
LRPE IES Y+Y+ TG+ T E G + EK +KV G++++ +++
Sbjct: 363 KREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLD 422
Query: 487 PRDMMESFFLSET 499
R MESFFL+ET
Sbjct: 423 NR--MESFFLAET 433
>BC016184-1|AAH16184.1| 578|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 2 protein.
Length = 578
Score = 138 bits (334), Expect = 5e-32
Identities = 123/433 (28%), Positives = 203/433 (46%), Gaps = 47/433 (10%)
Query: 83 PKNDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASD-WFSLGLTIVDSLDTAYIMGL 141
P + R+R F HA+ Y E+A+ D L+P++ D W S LT++D+LDT I+G
Sbjct: 32 PAHYRERVKA-MFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGN 90
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQ------------DQLF 189
F+ + +++ + F + + + FE IR++GGLL+ H ++
Sbjct: 91 VSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPL 150
Query: 190 LDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWSHYSTTAEVTTVQLEFRQLS 247
L A + +L+ AF +P+G+PY VNL G P + TA + T +EF LS
Sbjct: 151 LRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETP----VTCTAGIGTFIVEFATLS 206
Query: 248 RASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLL 307
+G+P+FE+ A ++ + GLV I+ TG ++ +GA DSY+EYL+
Sbjct: 207 SLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQ-DAGIGAGVDSYFEYLV 265
Query: 308 K-QWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTC 366
K L K + + +Y I F + L++ ++ G+ + P L
Sbjct: 266 KGAILLQDKKLMAMFLEYNKAIRNYTRF------DDWYLWV-QMYKGTVSM-PVFQSLEA 317
Query: 367 FLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKS 426
+ PG +L + + + T YT + + P F +N+ YT
Sbjct: 318 YWPGLQSL--IGDIDNAMRTFLN--YYTVWKQFGGLPEF-------YNIPQG----YTVE 362
Query: 427 ADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPI 486
LRPE IES Y+Y+ TG+ T E G + EK +KV G++++ +++
Sbjct: 363 KREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLD 422
Query: 487 PRDMMESFFLSET 499
R MESFFL+ET
Sbjct: 423 NR--MESFFLAET 433
>BC001371-1|AAH01371.1| 578|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 2 protein.
Length = 578
Score = 138 bits (334), Expect = 5e-32
Identities = 123/433 (28%), Positives = 203/433 (46%), Gaps = 47/433 (10%)
Query: 83 PKNDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASD-WFSLGLTIVDSLDTAYIMGL 141
P + R+R F HA+ Y E+A+ D L+P++ D W S LT++D+LDT I+G
Sbjct: 32 PAHYRERVKA-MFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGN 90
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQ------------DQLF 189
F+ + +++ + F + + + FE IR++GGLL+ H ++
Sbjct: 91 VSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPL 150
Query: 190 LDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWSHYSTTAEVTTVQLEFRQLS 247
L A + +L+ AF +P+G+PY VNL G P + TA + T +EF LS
Sbjct: 151 LRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETP----VTCTAGIGTFIVEFATLS 206
Query: 248 RASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLL 307
+G+P+FE+ A ++ + GLV I+ TG ++ +GA DSY+EYL+
Sbjct: 207 SLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQ-DAGIGAGVDSYFEYLV 265
Query: 308 K-QWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTC 366
K L K + + +Y I F + L++ ++ G+ + P L
Sbjct: 266 KGAILLQDKKLMAMFLEYNKAIRNYTRF------DDWYLWV-QMYKGTVSM-PVFQSLEA 317
Query: 367 FLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKS 426
+ PG +L + + + T YT + + P F +N+ YT
Sbjct: 318 YWPGLQSL--IGDIDNAMRTFLN--YYTVWKQFGGLPEF-------YNIPQG----YTVE 362
Query: 427 ADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPI 486
LRPE IES Y+Y+ TG+ T E G + EK +KV G++++ +++
Sbjct: 363 KREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLD 422
Query: 487 PRDMMESFFLSET 499
R MESFFL+ET
Sbjct: 423 NR--MESFFLAET 433
>AL356652-1|CAH73763.1| 578|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 2 protein.
Length = 578
Score = 138 bits (334), Expect = 5e-32
Identities = 123/433 (28%), Positives = 203/433 (46%), Gaps = 47/433 (10%)
Query: 83 PKNDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASD-WFSLGLTIVDSLDTAYIMGL 141
P + R+R F HA+ Y E+A+ D L+P++ D W S LT++D+LDT I+G
Sbjct: 32 PAHYRERVKA-MFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGN 90
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQ------------DQLF 189
F+ + +++ + F + + + FE IR++GGLL+ H ++
Sbjct: 91 VSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPL 150
Query: 190 LDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWSHYSTTAEVTTVQLEFRQLS 247
L A + +L+ AF +P+G+PY VNL G P + TA + T +EF LS
Sbjct: 151 LRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETP----VTCTAGIGTFIVEFATLS 206
Query: 248 RASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLL 307
+G+P+FE+ A ++ + GLV I+ TG ++ +GA DSY+EYL+
Sbjct: 207 SLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQ-DAGIGAGVDSYFEYLV 265
Query: 308 K-QWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTC 366
K L K + + +Y I F + L++ ++ G+ + P L
Sbjct: 266 KGAILLQDKKLMAMFLEYNKAIRNYTRF------DDWYLWV-QMYKGTVSM-PVFQSLEA 317
Query: 367 FLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKS 426
+ PG +L + + + T YT + + P F +N+ YT
Sbjct: 318 YWPGLQSL--IGDIDNAMRTFLN--YYTVWKQFGGLPEF-------YNIPQG----YTVE 362
Query: 427 ADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPI 486
LRPE IES Y+Y+ TG+ T E G + EK +KV G++++ +++
Sbjct: 363 KREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLD 422
Query: 487 PRDMMESFFLSET 499
R MESFFL+ET
Sbjct: 423 NR--MESFFLAET 433
>AL135844-1|CAI19292.1| 578|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 2 protein.
Length = 578
Score = 138 bits (334), Expect = 5e-32
Identities = 123/433 (28%), Positives = 203/433 (46%), Gaps = 47/433 (10%)
Query: 83 PKNDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASD-WFSLGLTIVDSLDTAYIMGL 141
P + R+R F HA+ Y E+A+ D L+P++ D W S LT++D+LDT I+G
Sbjct: 32 PAHYRERVKA-MFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGN 90
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQ------------DQLF 189
F+ + +++ + F + + + FE IR++GGLL+ H ++
Sbjct: 91 VSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPL 150
Query: 190 LDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWSHYSTTAEVTTVQLEFRQLS 247
L A + +L+ AF +P+G+PY VNL G P + TA + T +EF LS
Sbjct: 151 LRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETP----VTCTAGIGTFIVEFATLS 206
Query: 248 RASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLL 307
+G+P+FE+ A ++ + GLV I+ TG ++ +GA DSY+EYL+
Sbjct: 207 SLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQ-DAGIGAGVDSYFEYLV 265
Query: 308 K-QWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTC 366
K L K + + +Y I F + L++ ++ G+ + P L
Sbjct: 266 KGAILLQDKKLMAMFLEYNKAIRNYTRF------DDWYLWV-QMYKGTVSM-PVFQSLEA 317
Query: 367 FLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKS 426
+ PG +L + + + T YT + + P F +N+ YT
Sbjct: 318 YWPGLQSL--IGDIDNAMRTFLN--YYTVWKQFGGLPEF-------YNIPQG----YTVE 362
Query: 427 ADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPI 486
LRPE IES Y+Y+ TG+ T E G + EK +KV G++++ +++
Sbjct: 363 KREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLD 422
Query: 487 PRDMMESFFLSET 499
R MESFFL+ET
Sbjct: 423 NR--MESFFLAET 433
>AK023931-1|BAB14731.1| 578|Homo sapiens protein ( Homo sapiens
cDNA FLJ13869 fis, clone THYRO1001287, weakly similar to
MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE (EC
3.2.1.113). ).
Length = 578
Score = 138 bits (334), Expect = 5e-32
Identities = 123/433 (28%), Positives = 203/433 (46%), Gaps = 47/433 (10%)
Query: 83 PKNDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASD-WFSLGLTIVDSLDTAYIMGL 141
P + R+R F HA+ Y E+A+ D L+P++ D W S LT++D+LDT I+G
Sbjct: 32 PAHYRERVKA-MFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGN 90
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQ------------DQLF 189
F+ + +++ + F + + + FE IR++GGLL+ H ++
Sbjct: 91 VSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPL 150
Query: 190 LDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWSHYSTTAEVTTVQLEFRQLS 247
L A + +L+ AF +P+G+PY VNL G P + TA + T +EF LS
Sbjct: 151 LRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETP----VTCTAGIGTFIVEFATLS 206
Query: 248 RASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLL 307
+G+P+FE+ A ++ + GLV I+ TG ++ +GA DSY+EYL+
Sbjct: 207 SLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQ-DAGIGAGVDSYFEYLV 265
Query: 308 K-QWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTC 366
K L K + + +Y I F + L++ ++ G+ + P L
Sbjct: 266 KGAILLQDKKLMAMFLEYNKAIRNYTRF------DDWYLWV-QMYKGTVSM-PVFQSLEA 317
Query: 367 FLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKS 426
+ PG +L + + + T YT + + P F +N+ YT
Sbjct: 318 YWPGLQSL--IGDIDNAMRTFLN--YYTVWKQFGGLPEF-------YNIPQG----YTVE 362
Query: 427 ADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPI 486
LRPE IES Y+Y+ TG+ T E G + EK +KV G++++ +++
Sbjct: 363 KREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLD 422
Query: 487 PRDMMESFFLSET 499
R MESFFL+ET
Sbjct: 423 NR--MESFFLAET 433
>AK001645-1|BAA91806.1| 578|Homo sapiens protein ( Homo sapiens
cDNA FLJ10783 fis, clone NT2RP4000417, weakly similar to
MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE (EC
3.2.1.113). ).
Length = 578
Score = 138 bits (334), Expect = 5e-32
Identities = 123/433 (28%), Positives = 203/433 (46%), Gaps = 47/433 (10%)
Query: 83 PKNDRQRALVESFRHAWRGYKEHAWGHDNLKPVSGMASD-WFSLGLTIVDSLDTAYIMGL 141
P + R+R F HA+ Y E+A+ D L+P++ D W S LT++D+LDT I+G
Sbjct: 32 PAHYRERVKA-MFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGN 90
Query: 142 TDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQ------------DQLF 189
F+ + +++ + F + + + FE IR++GGLL+ H ++
Sbjct: 91 VSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPL 150
Query: 190 LDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWSHYSTTAEVTTVQLEFRQLS 247
L A + +L+ AF +P+G+PY VNL G P + TA + T +EF LS
Sbjct: 151 LRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETP----VTCTAGIGTFIVEFATLS 206
Query: 248 RASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLL 307
+G+P+FE+ A ++ + GLV I+ TG ++ +GA DSY+EYL+
Sbjct: 207 SLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQ-DAGIGAGVDSYFEYLV 265
Query: 308 K-QWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKMDHLTC 366
K L K + + +Y I F + L++ ++ G+ + P L
Sbjct: 266 KGAILLQDKKLMAMFLEYNKAIRNYTRF------DDWYLWV-QMYKGTVSM-PVFQSLEA 317
Query: 367 FLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLAPEITHFNLASTTDDMYTKS 426
+ PG +L + + + T YT + + P F +N+ YT
Sbjct: 318 YWPGLQSL--IGDIDNAMRTFLN--YYTVWKQFGGLPEF-------YNIPQG----YTVE 362
Query: 427 ADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKYAKVPNGYSSLTNVKSENPI 486
LRPE IES Y+Y+ TG+ T E G + EK +KV G++++ +++
Sbjct: 363 KREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLD 422
Query: 487 PRDMMESFFLSET 499
R MESFFL+ET
Sbjct: 423 NR--MESFFLAET 433
>BC065827-1|AAH65827.1| 367|Homo sapiens MAN1A1 protein protein.
Length = 367
Score = 127 bits (306), Expect = 1e-28
Identities = 58/130 (44%), Positives = 89/130 (68%), Gaps = 4/130 (3%)
Query: 92 VESFRHAWRGYKEHAWGHDNLKPVS--GMASDWFS--LGLTIVDSLDTAYIMGLTDVFEE 147
++ +HAW YK +AWG + LKP+S G +S F G TIVD+LDT +IM + FEE
Sbjct: 223 IQMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEE 282
Query: 148 GKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHYFTQDQLFLDKAIDLGDRLMAAFSSP 207
K W++E L F N +++ FEV IR +GGLL+ +Y + +++F KA++LG +L+ AF +P
Sbjct: 283 AKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHTP 342
Query: 208 SGIPYSDVNL 217
SGIP++ +N+
Sbjct: 343 SGIPWALLNM 352
>AL157902-2|CAI22316.1| 203|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 203
Score = 121 bits (292), Expect = 6e-27
Identities = 66/188 (35%), Positives = 98/188 (52%), Gaps = 8/188 (4%)
Query: 346 FIGELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPD---WHMTMAEELLYTCYLTYAAH 402
FIGE G KM HL CF G ALG D ++ + E+ TC+ +Y
Sbjct: 10 FIGEWKNGH--LEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRT 67
Query: 403 PTFLAPEITHFNLASTTDDMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQ 462
L PE F + + + A+ + +LRPE IE+ WY+++ T + Y++WGW+
Sbjct: 68 ALKLGPE--SFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAAL 125
Query: 463 GFEKYAKVPNGYSSLTNVKSENPIPRDMMESFFLSETXXXXXXXXSDDRFLIDLNKYVVN 522
EKY +V G+S + +V S P D+ +SFFL+ET S D L+ L+ +V N
Sbjct: 126 AIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDD-LLPLDHWVFN 184
Query: 523 SEAHPLPI 530
+EAHPLP+
Sbjct: 185 TEAHPLPV 192
>AY358580-1|AAQ88943.1| 541|Homo sapiens C20orf31 protein.
Length = 541
Score = 120 bits (289), Expect = 1e-26
Identities = 109/392 (27%), Positives = 182/392 (46%), Gaps = 45/392 (11%)
Query: 123 FSLGLTIVDSLDTAYIMGLTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNHY 182
+S LT++D+LDT I+G F+ + +++ + F + + + FE IR++GGLL+ H
Sbjct: 35 YSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHL 94
Query: 183 FTQDQ------------LFLDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWS 228
++ L A + +L+ AF +P+G+PY VNL G P
Sbjct: 95 LSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETP--- 151
Query: 229 HYSTTAEVTTVQLEFRQLSRASGNPIFEEAAAAVSEKIHQLPKKHGLVPIFINPNTGHFL 288
+ TA + T +EF LS +G+P+FE+ A ++ + GLV I+ TG ++
Sbjct: 152 -VTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWV 210
Query: 289 PHATITLGARGDSYYEYLLK-QWLQTGKTINYLLDDYLTGIEGVREFLAKRSSPNKRLFI 347
+GA DSY+EYL+K L K + + +Y I F + L++
Sbjct: 211 AQ-DAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRF------DDWYLWV 263
Query: 348 GELSAGSEAFNPKMDHLTCFLPGTLALGHLNGLPDWHMTMAEELLYTCYLTYAAHPTFLA 407
++ G+ + P L + PG +L + + + T YT + + P F
Sbjct: 264 -QMYKGTVSM-PVFQSLEAYWPGLQSL--IGDIDNAMRTFLN--YYTVWKQFGGLPEF-- 315
Query: 408 PEITHFNLASTTDDMYTKSADAHSLLRPEFIESLWYMYQITGNTTYQEWGWQIFQGFEKY 467
+N+ YT LRPE IES Y+Y+ TG+ T E G + EK
Sbjct: 316 -----YNIPQG----YTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKI 366
Query: 468 AKVPNGYSSLTNVKSENPIPRDMMESFFLSET 499
+KV G++++ +++ R MESFFL+ET
Sbjct: 367 SKVECGFATIKDLRDHKLDNR--MESFFLAET 396
>AK127005-1|BAC86786.1| 223|Homo sapiens protein ( Homo sapiens
cDNA FLJ45060 fis, clone BRAWH3023415, highly similar
to Homo sapiens alpha 1,2-mannosidase (LOC51697). ).
Length = 223
Score = 109 bits (263), Expect = 2e-23
Identities = 57/107 (53%), Positives = 71/107 (66%), Gaps = 3/107 (2%)
Query: 256 EEAAAAVSEKIHQLP-KKHGLVPIFINPNTGHFLPHATITLGARGDSYYEYLLKQWLQTG 314
+EA V++ IH L KK GLVP+FIN ++G F TLGAR DSYYEYLLKQW+Q G
Sbjct: 91 QEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGG 150
Query: 315 KTINYLLDDYLTGIEGVREFLAKRSSPNKRLFIGELSAGSEAFNPKM 361
K LL+DY+ IEGVR L + S P+K F+GEL+ G F+ KM
Sbjct: 151 KQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG--RFSAKM 195
>BC105586-1|AAI05587.1| 242|Homo sapiens EDEM3 protein protein.
Length = 242
Score = 96.7 bits (230), Expect = 2e-19
Identities = 74/205 (36%), Positives = 107/205 (52%), Gaps = 19/205 (9%)
Query: 127 LTIVDSLDTAYIMGLTDVFEEGKQWIKEELIFTKNKDVNFFEVTIRILGGLLTNH----- 181
LT++DSLDT ++ T FE+ + + ++ + V+ FE IR+LGGLL H
Sbjct: 28 LTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIM 87
Query: 182 --------YFTQDQLFLDKAIDLGDRLMAAFSSPSGIPYSDVNL--GARTAHAPEWSHYS 231
+ D+L L A LG +L+ AF++ SG+PY +NL G R A +
Sbjct: 88 LKEKGEYMQWYNDEL-LQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETD 146
Query: 232 T-TAEVTTVQLEFRQLSRASGNPIFEE-AAAAVSEKIHQLPKKHGLVPIFINPNTGHFLP 289
T TA T+ LEF LSR +G IFEE A A+ + + LV + IN +TG ++
Sbjct: 147 TCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWV- 205
Query: 290 HATITLGARGDSYYEYLLKQWLQTG 314
+GA DSYYEYLLK ++ G
Sbjct: 206 RKDSGVGAGIDSYYEYLLKAYVLLG 230
>AL157902-3|CAI22317.1| 97|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 97
Score = 56.4 bits (130), Expect = 2e-07
Identities = 28/66 (42%), Positives = 40/66 (60%), Gaps = 1/66 (1%)
Query: 465 EKYAKVPNGYSSLTNVKSENPIPRDMMESFFLSETXXXXXXXXSDDRFLIDLNKYVVNSE 524
EKY +V G+S + +V S P D+ +SFFL+ET S D L+ L+ +V N+E
Sbjct: 1 EKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDD-LLPLDHWVFNTE 59
Query: 525 AHPLPI 530
AHPLP+
Sbjct: 60 AHPLPV 65
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.135 0.412
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 77,435,157
Number of Sequences: 224733
Number of extensions: 3272989
Number of successful extensions: 5309
Number of sequences better than 10.0: 43
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 5054
Number of HSP's gapped (non-prelim): 79
length of query: 533
length of database: 73,234,838
effective HSP length: 93
effective length of query: 440
effective length of database: 52,334,669
effective search space: 23027254360
effective search space used: 23027254360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 68 (31.5 bits)
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