Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000563-TA|BGIBMGA000563-PA|IPR005962|Tyrosine
3-monooxygenase, IPR001273|Aromatic amino acid hydroxylase
(561 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 469 e-131
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 465 e-130
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 465 e-130
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 465 e-130
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 423 e-117
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 423 e-117
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 421 e-117
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 420 e-117
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 408 e-113
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 408 e-113
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 408 e-113
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 396 e-110
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 396 e-110
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 392 e-108
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 230 1e-59
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 230 1e-59
AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase ... 208 4e-53
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 130 2e-29
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 124 8e-28
AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens ... 91 1e-17
BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein. 86 3e-16
AY196346-1|AAO72076.1| 74|Homo sapiens tryptophan hydroxylase ... 71 1e-11
AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine hydr... 65 7e-10
S61396-1|AAD13928.1| 26|Homo sapiens PAH protein. 48 1e-04
S61296-1|AAD13926.1| 25|Homo sapiens PAH protein. 37 0.16
S75697-1|AAD14181.1| 26|Homo sapiens PAH protein. 34 1.2
AY722626-1|AAU11305.1| 23|Homo sapiens phenylalanine hydroxyla... 34 1.5
AF057280-2|AAC69458.1| 57|Homo sapiens tryptophan hydroxylase ... 33 2.0
AF057280-1|AAC69459.1| 79|Homo sapiens tryptophan hydroxylase ... 33 2.7
BX641037-1|CAE46023.1| 441|Homo sapiens hypothetical protein pr... 31 8.1
BC107570-1|AAI07571.1| 520|Homo sapiens BAZ2B protein protein. 31 8.1
BC012576-1|AAH12576.1| 643|Homo sapiens BAZ2B protein protein. 31 8.1
AB040909-1|BAA96000.2| 2142|Homo sapiens KIAA1476 protein protein. 31 8.1
AB032255-1|BAA89212.1| 1972|Homo sapiens bromodomain adjacent to... 31 8.1
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 469 bits (1155), Expect = e-131
Identities = 219/408 (53%), Positives = 294/408 (72%), Gaps = 9/408 (2%)
Query: 151 SLARILKTIDNYKGCVQHLETRPSQ---VTGVQFDALVKVSMTRINLIQLIRSLRQSTAF 207
+L+R +K + ++ + HLETRP+Q G + V++ + R +L L+ +RQ
Sbjct: 95 ALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQ---- 150
Query: 208 AGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRKQIAE 267
V+ + K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR+RRK IAE
Sbjct: 151 --VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAE 208
Query: 268 IAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAADIFVPHR 327
IAF Y++GDPIP + YT E TW+ V+ T+ L HAC E+ AF L+ +
Sbjct: 209 IAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDN 268
Query: 328 IPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPFHTPEPDC 387
IPQLEDVS FL++ TGF LRP AGLL+ARDFLASLAFRVFQ TQY+RH +SP H+PEPDC
Sbjct: 269 IPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDC 328
Query: 388 IHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKENQQLKAY 447
HELLGH+P+LAD +FAQFSQ+IGLASLGASD EIEKLST+YWFTVEFGLCK+N ++KAY
Sbjct: 329 CHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAY 388
Query: 448 GAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKFRRWV 507
GA LLSS GELLH LS++PE+R F+P + +VQPYQDQ YQ +Y+V+E+F DAKDK R +
Sbjct: 389 GAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYA 448
Query: 508 STMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
S + RPF V+F+P+T ++VLDS + + + E+ L +A+ +
Sbjct: 449 SRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAI 496
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 465 bits (1146), Expect = e-130
Identities = 218/408 (53%), Positives = 293/408 (71%), Gaps = 9/408 (2%)
Query: 151 SLARILKTIDNYKGCVQHLETRPSQ---VTGVQFDALVKVSMTRINLIQLIRSLRQSTAF 207
+L+R +K + ++ + HLETRP+Q G + V++ + R +L L+ +RQ
Sbjct: 122 ALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQ---- 177
Query: 208 AGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRKQIAE 267
V+ + K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR+RRK IAE
Sbjct: 178 --VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAE 235
Query: 268 IAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAADIFVPHR 327
IAF Y++GDPIP + YT E TW+ V+ T+ L HAC E+ AF L+ +
Sbjct: 236 IAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDN 295
Query: 328 IPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPFHTPEPDC 387
IPQLEDVS FL++ TGF LRP AGLL+ARDFLASLAFRVFQ TQY+RH +SP H+PEPDC
Sbjct: 296 IPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDC 355
Query: 388 IHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKENQQLKAY 447
HELLGH+P+LAD +FAQFSQ+IGLASLGASD EIEKLST+ WFTVEFGLCK+N ++KAY
Sbjct: 356 CHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAY 415
Query: 448 GAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKFRRWV 507
GA LLSS GELLH LS++PE+R F+P + +VQPYQDQ YQ +Y+V+E+F DAKDK R +
Sbjct: 416 GAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYA 475
Query: 508 STMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
S + RPF V+F+P+T ++VLDS + + + E+ L +A+ +
Sbjct: 476 SRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAI 523
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 465 bits (1146), Expect = e-130
Identities = 218/408 (53%), Positives = 293/408 (71%), Gaps = 9/408 (2%)
Query: 151 SLARILKTIDNYKGCVQHLETRPSQ---VTGVQFDALVKVSMTRINLIQLIRSLRQSTAF 207
+L+R +K + ++ + HLETRP+Q G + V++ + R +L L+ +RQ
Sbjct: 95 ALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQ---- 150
Query: 208 AGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRKQIAE 267
V+ + K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR+RRK IAE
Sbjct: 151 --VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAE 208
Query: 268 IAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAADIFVPHR 327
IAF Y++GDPIP + YT E TW+ V+ T+ L HAC E+ AF L+ +
Sbjct: 209 IAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDN 268
Query: 328 IPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPFHTPEPDC 387
IPQLEDVS FL++ TGF LRP AGLL+ARDFLASLAFRVFQ TQY+RH +SP H+PEPDC
Sbjct: 269 IPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDC 328
Query: 388 IHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKENQQLKAY 447
HELLGH+P+LAD +FAQFSQ+IGLASLGASD EIEKLST+ WFTVEFGLCK+N ++KAY
Sbjct: 329 CHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAY 388
Query: 448 GAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKFRRWV 507
GA LLSS GELLH LS++PE+R F+P + +VQPYQDQ YQ +Y+V+E+F DAKDK R +
Sbjct: 389 GAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYA 448
Query: 508 STMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
S + RPF V+F+P+T ++VLDS + + + E+ L +A+ +
Sbjct: 449 SRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAI 496
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 465 bits (1146), Expect = e-130
Identities = 218/408 (53%), Positives = 293/408 (71%), Gaps = 9/408 (2%)
Query: 151 SLARILKTIDNYKGCVQHLETRPSQ---VTGVQFDALVKVSMTRINLIQLIRSLRQSTAF 207
+L+R +K + ++ + HLETRP+Q G + V++ + R +L L+ +RQ
Sbjct: 126 ALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQ---- 181
Query: 208 AGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRKQIAE 267
V+ + K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR+RRK IAE
Sbjct: 182 --VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAE 239
Query: 268 IAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAADIFVPHR 327
IAF Y++GDPIP + YT E TW+ V+ T+ L HAC E+ AF L+ +
Sbjct: 240 IAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDN 299
Query: 328 IPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPFHTPEPDC 387
IPQLEDVS FL++ TGF LRP AGLL+ARDFLASLAFRVFQ TQY+RH +SP H+PEPDC
Sbjct: 300 IPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDC 359
Query: 388 IHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKENQQLKAY 447
HELLGH+P+LAD +FAQFSQ+IGLASLGASD EIEKLST+ WFTVEFGLCK+N ++KAY
Sbjct: 360 CHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAY 419
Query: 448 GAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKFRRWV 507
GA LLSS GELLH LS++PE+R F+P + +VQPYQDQ YQ +Y+V+E+F DAKDK R +
Sbjct: 420 GAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYA 479
Query: 508 STMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
S + RPF V+F+P+T ++VLDS + + + E+ L +A+ +
Sbjct: 480 SRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAI 527
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 423 bits (1041), Expect = e-117
Identities = 203/413 (49%), Positives = 277/413 (67%), Gaps = 2/413 (0%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRIN-LIQLIRSLRQ 203
+++ +G+LA++L+ + + H+E+RPS++ +++ + + L +I+ LR
Sbjct: 41 LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRH 100
Query: 204 STAFAGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRK 263
A V+ L+ + PWFPR +LD + + Y ELD +HPGF D YR RRK
Sbjct: 101 DIG-ATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRK 159
Query: 264 QIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAADIF 323
Q A+IA+ Y++G PIP + Y E E TW VF T+ L HAC EY F L+ F
Sbjct: 160 QFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGF 219
Query: 324 VPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPFHTP 383
IPQLEDVS FL+ TGF LRP AGLL++RDFL LAFRVF TQY+RH + P +TP
Sbjct: 220 HEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTP 279
Query: 384 EPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKENQQ 443
EPD HELLGH+PL +D SFAQFSQEIGLASLGA D IEKL+T+YWFTVEFGLCK+
Sbjct: 280 EPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDS 339
Query: 444 LKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKF 503
+KAYGA LLSS GEL + LS+KP+L P E T++Q Y E+QP+YYVAE+F DAK+K
Sbjct: 340 IKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKV 399
Query: 504 RRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKLK 556
R + +T+ RPF VR++P+T+R+EVLD+ +L+ L +N+E+ L +A++K+K
Sbjct: 400 RNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK 452
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 423 bits (1041), Expect = e-117
Identities = 203/413 (49%), Positives = 277/413 (67%), Gaps = 2/413 (0%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRIN-LIQLIRSLRQ 203
+++ +G+LA++L+ + + H+E+RPS++ +++ + + L +I+ LR
Sbjct: 41 LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRH 100
Query: 204 STAFAGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRK 263
A V+ L+ + PWFPR +LD + + Y ELD +HPGF D YR RRK
Sbjct: 101 DIG-ATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRK 159
Query: 264 QIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAADIF 323
Q A+IA+ Y++G PIP + Y E E TW VF T+ L HAC EY F L+ F
Sbjct: 160 QFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGF 219
Query: 324 VPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPFHTP 383
IPQLEDVS FL+ TGF LRP AGLL++RDFL LAFRVF TQY+RH + P +TP
Sbjct: 220 HEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTP 279
Query: 384 EPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKENQQ 443
EPD HELLGH+PL +D SFAQFSQEIGLASLGA D IEKL+T+YWFTVEFGLCK+
Sbjct: 280 EPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDS 339
Query: 444 LKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKF 503
+KAYGA LLSS GEL + LS+KP+L P E T++Q Y E+QP+YYVAE+F DAK+K
Sbjct: 340 IKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKV 399
Query: 504 RRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKLK 556
R + +T+ RPF VR++P+T+R+EVLD+ +L+ L +N+E+ L +A++K+K
Sbjct: 400 RNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK 452
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 421 bits (1038), Expect = e-117
Identities = 202/413 (48%), Positives = 277/413 (67%), Gaps = 2/413 (0%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRIN-LIQLIRSLRQ 203
+++ +G+LA++L+ + + H+E+RPS++ +++ + + L +I+ LR
Sbjct: 41 LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRH 100
Query: 204 STAFAGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRK 263
A V+ L+ + PWFPR +LD + + Y ELD +HPGF D YR RRK
Sbjct: 101 DIG-ATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRK 159
Query: 264 QIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAADIF 323
Q A+IA+ Y++G PIP + Y E E TW VF T+ L HAC EY F L+ F
Sbjct: 160 QFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGF 219
Query: 324 VPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPFHTP 383
IPQLEDVS FL+ TGF LRP AGLL++RDFL LAFRVF TQY+RH + P +TP
Sbjct: 220 HEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTP 279
Query: 384 EPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKENQQ 443
+PD HELLGH+PL +D SFAQFSQEIGLASLGA D IEKL+T+YWFTVEFGLCK+
Sbjct: 280 QPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDS 339
Query: 444 LKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKF 503
+KAYGA LLSS GEL + LS+KP+L P E T++Q Y E+QP+YYVAE+F DAK+K
Sbjct: 340 IKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKV 399
Query: 504 RRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKLK 556
R + +T+ RPF VR++P+T+R+EVLD+ +L+ L +N+E+ L +A++K+K
Sbjct: 400 RNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK 452
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 420 bits (1034), Expect = e-117
Identities = 202/413 (48%), Positives = 276/413 (66%), Gaps = 2/413 (0%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRIN-LIQLIRSLRQ 203
+++ +G+LA++L+ + + H+E+RPS++ +++ + + L +I+ LR
Sbjct: 41 LKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRH 100
Query: 204 STAFAGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRK 263
A V+ L+ + PWFPR +LD + + Y ELD +HPGF D YR RRK
Sbjct: 101 DIG-ATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRK 159
Query: 264 QIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAADIF 323
Q A+IA+ Y++G PIP + Y E TW VF T+ L HAC EY F L+ F
Sbjct: 160 QFADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGF 219
Query: 324 VPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPFHTP 383
IPQLEDVS FL+ TGF LRP AGLL++RDFL LAFRVF TQY+RH + P +TP
Sbjct: 220 HEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTP 279
Query: 384 EPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKENQQ 443
EPD HELLGH+PL +D SFAQFSQEIGLASLGA D IEKL+T+YWFTVEFGLCK+
Sbjct: 280 EPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDS 339
Query: 444 LKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKF 503
+KAYGA LLSS GEL + LS+KP+L P E T++Q Y E+QP+YYVAE+F DAK+K
Sbjct: 340 IKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKV 399
Query: 504 RRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKLK 556
R + +T+ RPF VR++P+T+R+EVLD+ +L+ L +N+E+ L +A++K+K
Sbjct: 400 RNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK 452
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 408 bits (1005), Expect = e-113
Identities = 192/415 (46%), Positives = 269/415 (64%), Gaps = 4/415 (0%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQS 204
+++ +G L + L+ + + H+E+R S+ + + V + +LI+ L+
Sbjct: 70 LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQ 129
Query: 205 TAFAGVN----LLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRE 260
T +N + TE PWFPR S+LD C+H + Y ELD +HPGF D YR+
Sbjct: 130 TTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQ 189
Query: 261 RRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAA 320
RRK ++A YKYG PIP + YTE E TW VF + L P HACREY F L
Sbjct: 190 RRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKY 249
Query: 321 DIFVPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPF 380
+ +PQLEDVS FL++ +GFT+RP AG L+ RDFLA LA+RVF TQY+RH + P
Sbjct: 250 CGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPL 309
Query: 381 HTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKE 440
+TPEPD HELLGH+PLLADP FAQFSQEIGLASLGASD +++KL+T Y+FT+EFGLCK+
Sbjct: 310 YTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQ 369
Query: 441 NQQLKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAK 500
QL+AYGA LLSSIGEL HALSDK ++ F+P +T +Q +Q Y+V+E+FE+AK
Sbjct: 370 EGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAK 429
Query: 501 DKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
+K R + +++RPF V FNP+T+ +E+L +E ++ L +++ + +A+ K+
Sbjct: 430 EKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKM 484
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 408 bits (1005), Expect = e-113
Identities = 192/415 (46%), Positives = 269/415 (64%), Gaps = 4/415 (0%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQS 204
+++ +G L + L+ + + H+E+R S+ + + V + +LI+ L+
Sbjct: 76 LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQ 135
Query: 205 TAFAGVN----LLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRE 260
T +N + TE PWFPR S+LD C+H + Y ELD +HPGF D YR+
Sbjct: 136 TTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQ 195
Query: 261 RRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAA 320
RRK ++A YKYG PIP + YTE E TW VF + L P HACREY F L
Sbjct: 196 RRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKY 255
Query: 321 DIFVPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPF 380
+ +PQLEDVS FL++ +GFT+RP AG L+ RDFLA LA+RVF TQY+RH + P
Sbjct: 256 CGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPL 315
Query: 381 HTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKE 440
+TPEPD HELLGH+PLLADP FAQFSQEIGLASLGASD +++KL+T Y+FT+EFGLCK+
Sbjct: 316 YTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQ 375
Query: 441 NQQLKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAK 500
QL+AYGA LLSSIGEL HALSDK ++ F+P +T +Q +Q Y+V+E+FE+AK
Sbjct: 376 EGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAK 435
Query: 501 DKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
+K R + +++RPF V FNP+T+ +E+L +E ++ L +++ + +A+ K+
Sbjct: 436 EKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKM 490
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 408 bits (1005), Expect = e-113
Identities = 192/415 (46%), Positives = 269/415 (64%), Gaps = 4/415 (0%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQS 204
+++ +G L + L+ + + H+E+R S+ + + V + +LI+ L+
Sbjct: 70 LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQ 129
Query: 205 TAFAGVN----LLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRE 260
T +N + TE PWFPR S+LD C+H + Y ELD +HPGF D YR+
Sbjct: 130 TTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQ 189
Query: 261 RRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAA 320
RRK ++A YKYG PIP + YTE E TW VF + L P HACREY F L
Sbjct: 190 RRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKY 249
Query: 321 DIFVPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPF 380
+ +PQLEDVS FL++ +GFT+RP AG L+ RDFLA LA+RVF TQY+RH + P
Sbjct: 250 CGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPL 309
Query: 381 HTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKE 440
+TPEPD HELLGH+PLLADP FAQFSQEIGLASLGASD +++KL+T Y+FT+EFGLCK+
Sbjct: 310 YTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQ 369
Query: 441 NQQLKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAK 500
QL+AYGA LLSSIGEL HALSDK ++ F+P +T +Q +Q Y+V+E+FE+AK
Sbjct: 370 EGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAK 429
Query: 501 DKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
+K R + +++RPF V FNP+T+ +E+L +E ++ L +++ + +A+ K+
Sbjct: 430 EKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKM 484
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 396 bits (976), Expect = e-110
Identities = 192/416 (46%), Positives = 272/416 (65%), Gaps = 6/416 (1%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQS 204
+++ +G L + LK + H+E+R S+ +F+ V + R L + L+
Sbjct: 24 LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSH 83
Query: 205 TAFAGVNL-----LTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYR 259
T VNL L E+ + + PWFP+ SDLD+C + + Y ELD +HPGF D YR
Sbjct: 84 TNVLSVNLPDNFTLKEDGMET-VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYR 142
Query: 260 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 319
+RRK A++A YK+GDPIP + +TE E TW VF + L P HACREY L
Sbjct: 143 KRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSK 202
Query: 320 ADIFVPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSP 379
+ IPQLEDVS+FL++ TGF++RP AG L+ RDFL+ LAFRVF TQYVRH++ P
Sbjct: 203 YCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDP 262
Query: 380 FHTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCK 439
F+TPEPD HELLGH+PLLA+PSFAQFSQEIGLASLGAS+ ++KL+T Y+FTVEFGLCK
Sbjct: 263 FYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCK 322
Query: 440 ENQQLKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDA 499
++ QL+ +GA LLSSI EL HALS +++PF+P T Q +Q +Y+V+E+FEDA
Sbjct: 323 QDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDA 382
Query: 500 KDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
K+K R + T+ RPF V++NP+T +++L + + + +L ++ +++A+ K+
Sbjct: 383 KEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKV 438
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 396 bits (976), Expect = e-110
Identities = 192/416 (46%), Positives = 272/416 (65%), Gaps = 6/416 (1%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQS 204
+++ +G L + LK + H+E+R S+ +F+ V + R L + L+
Sbjct: 24 LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSH 83
Query: 205 TAFAGVNL-----LTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYR 259
T VNL L E+ + + PWFP+ SDLD+C + + Y ELD +HPGF D YR
Sbjct: 84 TNVLSVNLPDNFTLKEDGMET-VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYR 142
Query: 260 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQA 319
+RRK A++A YK+GDPIP + +TE E TW VF + L P HACREY L
Sbjct: 143 KRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSK 202
Query: 320 ADIFVPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSP 379
+ IPQLEDVS+FL++ TGF++RP AG L+ RDFL+ LAFRVF TQYVRH++ P
Sbjct: 203 YCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDP 262
Query: 380 FHTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCK 439
F+TPEPD HELLGH+PLLA+PSFAQFSQEIGLASLGAS+ ++KL+T Y+FTVEFGLCK
Sbjct: 263 FYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCK 322
Query: 440 ENQQLKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDA 499
++ QL+ +GA LLSSI EL HALS +++PF+P T Q +Q +Y+V+E+FEDA
Sbjct: 323 QDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDA 382
Query: 500 KDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
K+K R + T+ RPF V++NP+T +++L + + + +L ++ +++A+ K+
Sbjct: 383 KEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKV 438
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 392 bits (964), Expect = e-108
Identities = 188/415 (45%), Positives = 264/415 (63%), Gaps = 4/415 (0%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQS 204
+++ +G L + LK + H+E+R S+ +F+ V R L + L+
Sbjct: 24 LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDTNREQLNDIFHLLKSH 83
Query: 205 TAFAGV----NLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRE 260
T V N + PWFP+ SDLD+C + + Y ELD +HPGF D YR+
Sbjct: 84 TNVLSVTPPDNFTMKEEGMESVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRK 143
Query: 261 RRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAA 320
RRK A+ A +YKYGDPIP + +TE E TW VF + L P HACREY L
Sbjct: 144 RRKYFADSAMSYKYGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLSKY 203
Query: 321 DIFVPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPF 380
+ IPQLED+S+FL++ TGF++RP AG L+ RDFL+ LAFRVF TQYVRH++ PF
Sbjct: 204 CGYQEDNIPQLEDISNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPF 263
Query: 381 HTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKE 440
+TPEPD HELLGH+PLLA+PSFAQFSQEIGLASLGAS+ ++KL+T Y+FTVEFGLCK+
Sbjct: 264 YTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQ 323
Query: 441 NQQLKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAK 500
+ QL+ +GA LLSSI EL H LS +++PF+P T Q +Q +Y+V+E+FEDAK
Sbjct: 324 DGQLRVFGAGLLSSISELKHVLSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAK 383
Query: 501 DKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
+K R + T+ RPF V++NP+T +++L + + +L ++ +++A+ K+
Sbjct: 384 EKMREFTKTIKRPFGVKYNPYTRSIQILKDAKSITNAMNELRHDLDVVSDALGKV 438
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 230 bits (562), Expect = 1e-59
Identities = 107/200 (53%), Positives = 143/200 (71%)
Query: 356 RDFLASLAFRVFQSTQYVRHNNSPFHTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASL 415
R +A +AF+ R + DC HELLGH+P+LAD +FAQFSQ+IGLASL
Sbjct: 207 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 266
Query: 416 GASDSEIEKLSTVYWFTVEFGLCKENQQLKAYGAALLSSIGELLHALSDKPELRPFEPAS 475
GASD EIEKLST+YWFTVEFGLCK+N ++KAYGA LLSS GELLH LS++PE+R F+P +
Sbjct: 267 GASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEA 326
Query: 476 TSVQPYQDQEYQPIYYVAETFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLE 535
+VQPYQDQ YQ +Y+V+E+F DAKDK R + S + RPF V+F+P+T ++VLDS +
Sbjct: 327 AAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVR 386
Query: 536 TLIWQLNTEMLHLTNAVKKL 555
+ + E+ L +A+ +
Sbjct: 387 RSLEGVQDELDTLAHALSAI 406
Score = 132 bits (319), Expect = 3e-30
Identities = 62/144 (43%), Positives = 93/144 (64%), Gaps = 9/144 (6%)
Query: 151 SLARILKTIDNYKGCVQHLETRPSQ---VTGVQFDALVKVSMTRINLIQLIRSLRQSTAF 207
+L+R +K + ++ + HLETRP+Q G + V++ + R +L L+ +RQ
Sbjct: 99 ALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQ---- 154
Query: 208 AGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRKQIAE 267
V+ + K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR+RRK IAE
Sbjct: 155 --VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAE 212
Query: 268 IAFAYKYGDPIPSIAYTEIENGTW 291
IAF Y++GDPIP + YT E TW
Sbjct: 213 IAFQYRHGDPIPRVEYTAEEIATW 236
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 230 bits (562), Expect = 1e-59
Identities = 107/200 (53%), Positives = 143/200 (71%)
Query: 356 RDFLASLAFRVFQSTQYVRHNNSPFHTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASL 415
R +A +AF+ R + DC HELLGH+P+LAD +FAQFSQ+IGLASL
Sbjct: 203 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 262
Query: 416 GASDSEIEKLSTVYWFTVEFGLCKENQQLKAYGAALLSSIGELLHALSDKPELRPFEPAS 475
GASD EIEKLST+YWFTVEFGLCK+N ++KAYGA LLSS GELLH LS++PE+R F+P +
Sbjct: 263 GASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEA 322
Query: 476 TSVQPYQDQEYQPIYYVAETFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLE 535
+VQPYQDQ YQ +Y+V+E+F DAKDK R + S + RPF V+F+P+T ++VLDS +
Sbjct: 323 AAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVR 382
Query: 536 TLIWQLNTEMLHLTNAVKKL 555
+ + E+ L +A+ +
Sbjct: 383 RSLEGVQDELDTLAHALSAI 402
Score = 132 bits (319), Expect = 3e-30
Identities = 62/144 (43%), Positives = 93/144 (64%), Gaps = 9/144 (6%)
Query: 151 SLARILKTIDNYKGCVQHLETRPSQ---VTGVQFDALVKVSMTRINLIQLIRSLRQSTAF 207
+L+R +K + ++ + HLETRP+Q G + V++ + R +L L+ +RQ
Sbjct: 95 ALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQ---- 150
Query: 208 AGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRKQIAE 267
V+ + K PWFPR S+LD C+HL+TK++P+LD++HPGF+D+ YR+RRK IAE
Sbjct: 151 --VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAE 208
Query: 268 IAFAYKYGDPIPSIAYTEIENGTW 291
IAF Y++GDPIP + YT E TW
Sbjct: 209 IAFQYRHGDPIPRVEYTAEEIATW 232
>AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase
protein.
Length = 163
Score = 208 bits (508), Expect = 4e-53
Identities = 92/158 (58%), Positives = 124/158 (78%)
Query: 371 QYVRHNNSPFHTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYW 430
QYVRH++ PF+TPEPD HELLGH+PLLA+PSFAQFSQEIGLASLGAS+ ++KL+T Y+
Sbjct: 1 QYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYF 60
Query: 431 FTVEFGLCKENQQLKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIY 490
FTVEFGLCK++ QL+ +GA LLSSI EL HALS +++PF+P T Q +Q +Y
Sbjct: 61 FTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVY 120
Query: 491 YVAETFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVL 528
+V+E+FEDAK+K R + T+ RP V++NP+T +++L
Sbjct: 121 FVSESFEDAKEKMREFTKTIKRPPGVKYNPYTRSIQIL 158
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 130 bits (313), Expect = 2e-29
Identities = 66/171 (38%), Positives = 96/171 (56%), Gaps = 6/171 (3%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQS 204
+++ +G L + LK + H+E+R S+ +F+ V + R L ++ L+
Sbjct: 22 LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDILHLLKSH 81
Query: 205 TAFAGVNL-----LTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYR 259
T VNL L E+ + + PWFP+ SDLD+C + + Y ELD +HPGF D YR
Sbjct: 82 TNVLSVNLPDNFTLKEDGMET-VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYR 140
Query: 260 ERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREY 310
+RRK A++A YK+GDPIP + +TE E TW VF + L P HACREY
Sbjct: 141 KRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREY 191
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 124 bits (299), Expect = 8e-28
Identities = 60/99 (60%), Positives = 72/99 (72%)
Query: 356 RDFLASLAFRVFQSTQYVRHNNSPFHTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASL 415
R +A +AF+ R + DC HELLGH+P+LAD +FAQFSQ+IGLASL
Sbjct: 16 RKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIGLASL 75
Query: 416 GASDSEIEKLSTVYWFTVEFGLCKENQQLKAYGAALLSS 454
GASD EIEKLST+ WFTVEFGLCK+N ++KAYGA LLSS
Sbjct: 76 GASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLSS 114
Score = 70.5 bits (165), Expect = 1e-11
Identities = 44/115 (38%), Positives = 63/115 (54%), Gaps = 7/115 (6%)
Query: 247 DMNHPGFADKDYRERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHA 306
D++HPGF+D+ YR+RRK IAEIAF Y++GDPIP + YT E TW + +L +P A
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWD-CCHELLGHVPMLA 59
Query: 307 CREYKAAFEKLQAADIFV-PHRIPQLEDVSSF-----LRKHTGFTLRPAAGLLTA 355
R + + + A + I +L +S F L K G AGLL++
Sbjct: 60 DRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYGAGLLSS 114
>AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens
cDNA FLJ37295 fis, clone BRAMY2015311, moderately
similar to TRYPTOPHAN 5-MONOOXYGENASE (EC 1.14.16.4). ).
Length = 250
Score = 90.6 bits (215), Expect = 1e-17
Identities = 44/135 (32%), Positives = 70/135 (51%), Gaps = 4/135 (2%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQS 204
+++ +G L + L+ + + H+E+R S+ + + V + +LI+ L+
Sbjct: 70 LKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQ 129
Query: 205 TAFAGVN----LLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRE 260
T +N + TE PWFPR S+LD C+H + Y ELD +HPGF D YR+
Sbjct: 130 TTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQ 189
Query: 261 RRKQIAEIAFAYKYG 275
RRK ++A YKYG
Sbjct: 190 RRKYFVDVAMGYKYG 204
>BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein.
Length = 206
Score = 86.2 bits (204), Expect = 3e-16
Identities = 47/133 (35%), Positives = 70/133 (52%), Gaps = 4/133 (3%)
Query: 145 MRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQS 204
+++ +G L + LK + H+E+R S+ +F+ V + R L + L+
Sbjct: 24 LKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSH 83
Query: 205 TAFAGVNL---LTENNISSKT-PWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRE 260
T VNL T N +T PWFP+ SDLD+C + + Y ELD +HPGF D YR+
Sbjct: 84 TNVLSVNLPDNFTLNEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRK 143
Query: 261 RRKQIAEIAFAYK 273
RRK A++A YK
Sbjct: 144 RRKYFADLAMNYK 156
>AY196346-1|AAO72076.1| 74|Homo sapiens tryptophan hydroxylase
protein.
Length = 74
Score = 70.5 bits (165), Expect = 1e-11
Identities = 29/69 (42%), Positives = 46/69 (66%)
Query: 460 HALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKFRRWVSTMSRPFEVRFN 519
HALS +++PF+P T Q +Q +Y+V+E+FEDAK+K R T+ RPF V++N
Sbjct: 1 HALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMRESTKTIKRPFGVKYN 60
Query: 520 PHTERVEVL 528
P+T +++L
Sbjct: 61 PYTRSIQIL 69
>AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine
hydroxylase protein.
Length = 44
Score = 64.9 bits (151), Expect = 7e-10
Identities = 27/44 (61%), Positives = 35/44 (79%)
Query: 247 DMNHPGFADKDYRERRKQIAEIAFAYKYGDPIPSIAYTEIENGT 290
D++HPGF+D+ YR+RRK IAEIAF Y++GDPIP + YT E T
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIAT 44
>S61396-1|AAD13928.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 47.6 bits (108), Expect = 1e-04
Identities = 17/25 (68%), Positives = 21/25 (84%)
Query: 424 KLSTVYWFTVEFGLCKENQQLKAYG 448
KL+T+YWFTVEFG CK+ +KAYG
Sbjct: 1 KLATIYWFTVEFGFCKQGDSIKAYG 25
>S61296-1|AAD13926.1| 25|Homo sapiens PAH protein.
Length = 25
Score = 37.1 bits (82), Expect = 0.16
Identities = 14/25 (56%), Positives = 20/25 (80%)
Query: 485 EYQPIYYVAETFEDAKDKFRRWVST 509
E+QP+YYVA +F DAK+K R + +T
Sbjct: 1 EFQPLYYVAGSFNDAKEKVRNFAAT 25
>S75697-1|AAD14181.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 34.3 bits (75), Expect = 1.2
Identities = 15/23 (65%), Positives = 18/23 (78%)
Query: 337 FLRKHTGFTLRPAAGLLTARDFL 359
F+ TGF LRP AGLL++RDFL
Sbjct: 2 FIPACTGFCLRPVAGLLSSRDFL 24
>AY722626-1|AAU11305.1| 23|Homo sapiens phenylalanine hydroxylase
protein.
Length = 23
Score = 33.9 bits (74), Expect = 1.5
Identities = 13/22 (59%), Positives = 17/22 (77%)
Query: 481 YQDQEYQPIYYVAETFEDAKDK 502
Y E+QP+YYVAE+F D K+K
Sbjct: 1 YTVTEFQPLYYVAESFNDDKEK 22
>AF057280-2|AAC69458.1| 57|Homo sapiens tryptophan hydroxylase
isoform 1 protein.
Length = 57
Score = 33.5 bits (73), Expect = 2.0
Identities = 12/50 (24%), Positives = 31/50 (62%)
Query: 506 WVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKL 555
+ T+ RPF V++NP+T +++L + + + +L ++ +++A+ K+
Sbjct: 2 FTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKV 51
>AF057280-1|AAC69459.1| 79|Homo sapiens tryptophan hydroxylase
isoform 2 protein.
Length = 79
Score = 33.1 bits (72), Expect = 2.7
Identities = 12/49 (24%), Positives = 30/49 (61%)
Query: 506 WVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKK 554
+ T+ RPF V++NP+T +++L + + + +L ++ +++A+ K
Sbjct: 2 FTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAK 50
>BX641037-1|CAE46023.1| 441|Homo sapiens hypothetical protein
protein.
Length = 441
Score = 31.5 bits (68), Expect = 8.1
Identities = 16/58 (27%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Query: 35 DARFETLVVKQTKQSVLEEARARANDSGLESDFIQDGVHIGNGDNSPTVEDGTQQDET 92
DAR + + K+ ++ +E + +DSG SD +G I + D+ ED ++D++
Sbjct: 221 DARVDKIKDKKPRKKAMESSSNSDSDSGTSSDTSSEG--ISSSDSDDLEEDEEEEDQS 276
>BC107570-1|AAI07571.1| 520|Homo sapiens BAZ2B protein protein.
Length = 520
Score = 31.5 bits (68), Expect = 8.1
Identities = 16/58 (27%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Query: 35 DARFETLVVKQTKQSVLEEARARANDSGLESDFIQDGVHIGNGDNSPTVEDGTQQDET 92
DAR + + K+ ++ +E + +DSG SD +G I + D+ ED ++D++
Sbjct: 160 DARVDKIKDKKPRKKAMESSSNSDSDSGTSSDTSSEG--ISSSDSDDLEEDEEEEDQS 215
>BC012576-1|AAH12576.1| 643|Homo sapiens BAZ2B protein protein.
Length = 643
Score = 31.5 bits (68), Expect = 8.1
Identities = 16/58 (27%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Query: 35 DARFETLVVKQTKQSVLEEARARANDSGLESDFIQDGVHIGNGDNSPTVEDGTQQDET 92
DAR + + K+ ++ +E + +DSG SD +G I + D+ ED ++D++
Sbjct: 27 DARVDKIKDKKPRKKAMESSSNSDSDSGTSSDTSSEG--ISSSDSDDLEEDEEEEDQS 82
>AB040909-1|BAA96000.2| 2142|Homo sapiens KIAA1476 protein protein.
Length = 2142
Score = 31.5 bits (68), Expect = 8.1
Identities = 16/58 (27%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Query: 35 DARFETLVVKQTKQSVLEEARARANDSGLESDFIQDGVHIGNGDNSPTVEDGTQQDET 92
DAR + + K+ ++ +E + +DSG SD +G I + D+ ED ++D++
Sbjct: 231 DARVDKIKDKKPRKKAMESSSNSDSDSGTSSDTSSEG--ISSSDSDDLEEDEEEEDQS 286
>AB032255-1|BAA89212.1| 1972|Homo sapiens bromodomain adjacent to
zinc finger domain 2B protein.
Length = 1972
Score = 31.5 bits (68), Expect = 8.1
Identities = 16/58 (27%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Query: 35 DARFETLVVKQTKQSVLEEARARANDSGLESDFIQDGVHIGNGDNSPTVEDGTQQDET 92
DAR + + K+ ++ +E + +DSG SD +G I + D+ ED ++D++
Sbjct: 27 DARVDKIKDKKPRKKAMESSSNSDSDSGTSSDTSSEG--ISSSDSDDLEEDEEEEDQS 82
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.318 0.133 0.387
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 73,737,019
Number of Sequences: 224733
Number of extensions: 2869103
Number of successful extensions: 5654
Number of sequences better than 10.0: 34
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 5608
Number of HSP's gapped (non-prelim): 43
length of query: 561
length of database: 73,234,838
effective HSP length: 94
effective length of query: 467
effective length of database: 52,109,936
effective search space: 24335340112
effective search space used: 24335340112
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 68 (31.5 bits)
- SilkBase 1999-2023 -