Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000468-TA|BGIBMGA000468-PA|IPR000731|Sterol-sensing 5TM
box
(1118 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC011542-1|AAH11542.2| 1011|Homo sapiens DISP1 protein protein. 436 e-121
AB051529-1|BAB21833.2| 1301|Homo sapiens KIAA1742 protein protein. 420 e-116
AK026114-1|BAB15365.1| 917|Homo sapiens protein ( Homo sapiens ... 376 e-103
AK023679-1|BAB14637.1| 637|Homo sapiens protein ( Homo sapiens ... 279 3e-74
BC007734-1|AAH07734.1| 542|Homo sapiens DISP1 protein protein. 139 6e-32
AK098669-1|BAC05373.1| 542|Homo sapiens protein ( Homo sapiens ... 139 6e-32
AL590989-2|CAH70606.1| 1438|Homo sapiens patched domain containi... 56 7e-07
AL117236-1|CAB55303.1| 594|Homo sapiens hypothetical protein pr... 56 7e-07
AL031735-1|CAI22474.1| 1438|Homo sapiens patched domain containi... 56 7e-07
AB037758-1|BAA92575.1| 1438|Homo sapiens KIAA1337 protein protein. 56 7e-07
BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, t... 50 5e-05
AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1... 50 5e-05
AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein... 50 5e-05
AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease ... 50 5e-05
AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, t... 50 5e-05
U59464-1|AAC50550.1| 1447|Homo sapiens PATCHED protein. 39 0.087
U43148-1|AAC50496.1| 1296|Homo sapiens PTC protein. 39 0.087
AL161729-2|CAH73818.1| 1296|Homo sapiens patched homolog 1 (Dros... 39 0.087
AL161729-1|CAH73817.1| 1447|Homo sapiens patched homolog 1 (Dros... 39 0.087
AB233422-1|BAE45302.1| 348|Homo sapiens PTCH protein -10 protein. 39 0.087
AY395768-1|AAR21239.1| 651|Homo sapiens patched protein. 38 0.20
AK127397-1|BAC86958.1| 130|Homo sapiens protein ( Homo sapiens ... 38 0.27
AK126025-1|BAC86399.1| 804|Homo sapiens protein ( Homo sapiens ... 38 0.27
AY438664-1|AAR05447.1| 1203|Homo sapiens patched homolog 2 (Dros... 37 0.35
AY359016-1|AAQ89375.1| 1203|Homo sapiens Patched 2 protein. 37 0.35
AY358555-1|AAQ88919.1| 1211|Homo sapiens Patched 2 protein. 37 0.35
AL592166-5|CAI13000.1| 1203|Homo sapiens patched homolog 2 (Dros... 37 0.35
AL136380-1|CAI23127.1| 1203|Homo sapiens patched homolog 2 (Dros... 37 0.35
AF119569-1|AAD17260.1| 1146|Homo sapiens patched 2 protein. 37 0.35
AF091501-1|AAC79847.1| 1203|Homo sapiens receptor protein patche... 37 0.35
AF087651-1|AAD25953.1| 1203|Homo sapiens patched 2 protein. 37 0.35
AB209495-1|BAD92732.1| 586|Homo sapiens patched variant protein. 37 0.46
BC107139-1|AAI07140.1| 767|Homo sapiens patched domain containi... 36 1.1
BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein. 34 2.5
AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant p... 34 2.5
AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1 ... 34 2.5
AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like pr... 34 2.5
>BC011542-1|AAH11542.2| 1011|Homo sapiens DISP1 protein protein.
Length = 1011
Score = 436 bits (1074), Expect = e-121
Identities = 235/650 (36%), Positives = 377/650 (58%), Gaps = 48/650 (7%)
Query: 403 VFACVWIYTRSLILTLFLFAAITFSLGIAYFFYVYVFNLHFFPFMNLLVIVIVLGIGADD 462
V + +YT+S+ +TL AI SL ++YF Y VF+ FFPFMNL ++I++GIGADD
Sbjct: 1 VLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILVGIGADD 60
Query: 463 AFIYVKIWKMIGKQLIKDNVVYQENGVLDINISSAGETILVQILEETMRHSIVTIFITTL 522
AF+ +W Y + D + ET+ + T++H+ +++F+T+
Sbjct: 61 AFVLCDVWN------------YTK---FDKPHAETSETVSI-----TLQHAALSMFVTSF 100
Query: 523 TTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISV-----FIVDV------- 570
TTA AFYA+YVS I AI CF V+AGTA+LVN+VLM+TWLP V +++++
Sbjct: 101 TTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFTCFKKP 160
Query: 571 --KLYAKKKTFL---DLVHKNVNEMWENIRIVLNRFTIICVTKFHIAFVVVMGALGFISL 625
++Y K + HK + + E RI + V KF ++ AL
Sbjct: 161 QQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGA 220
Query: 626 VVVFYSPGLHLP--DSKQFQLFQTSHPFEQYEMQYRDKFLFERLSKDLGTGTKMPLRWVW 683
+V +P + LP + +FQ+F++SHPFE+Y+ +Y+ F+FER+ G MP+ +W
Sbjct: 221 YIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHH--GEELHMPITVIW 278
Query: 684 GVKAIDNGNHMDPASKGHLVFDENFSISDPKSQSWLLGFCARIKGQPFYQQTLGPLLPNC 743
GV DNGN ++P SKG L D +F+I+ P SQ+W+L FC +++ Q F+ QT +C
Sbjct: 279 GVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDFTSC 338
Query: 744 FIESFKMYMSRRCIDNIDKINRSPCCETSKFPYKKEVFDFCIIKAMESLYQTPRELFMPG 803
FIE+FK +M + + D+ PCC FPYK+E+F+ CI +A+ L ++
Sbjct: 339 FIETFKQWMENQ---DCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSK 395
Query: 804 VAGPKFLRSAKPPIIAALVVEFESIVPYSLSYSEMNKFFTEVEKWTQTELENAPAGMKCG 863
GP+F + I A+V+EF+S ++L+Y +M++F+ EV+ W +EL +AP G+ G
Sbjct: 396 TPGPRFDIN---DTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNG 452
Query: 864 WFLSDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIA 923
WF+S+ +FYDLQ +L+ GT++A+ LS A+ F V++ T N + S+ A+ ++ + VT+
Sbjct: 453 WFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVG 512
Query: 924 VLVINNWKLNILESVAISTSAGLAVDFSLHYALSYTNA-SGNKSARVKYXXXXXXXXXXX 982
LV+ W+LN+LESV IS + GL+VDF++HY ++Y A ++ +V +
Sbjct: 513 SLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAM 572
Query: 983 XXXXXGFAGVFLLRSNLLPYSQIGAFLVLIMTVSWTYATFFLCSLLHIVG 1032
AG ++ S +L Y+Q+G F++LIM +SW +ATFF + +G
Sbjct: 573 AALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLG 622
>AB051529-1|BAB21833.2| 1301|Homo sapiens KIAA1742 protein protein.
Length = 1301
Score = 420 bits (1034), Expect = e-116
Identities = 271/874 (31%), Positives = 437/874 (50%), Gaps = 69/874 (7%)
Query: 191 CGPPISDYAHLVITNTDNSSLLSYKNVERLCKFQSXXXXXXXXXXXXXCQRTTHSEDICC 250
CGPP YA LV +T + SL + + +C+ + CQRT ++ CC
Sbjct: 179 CGPPEKSYAKLVFMSTSSGSLWNLHAIHSMCRMEQDQIRSHTSFGAL-CQRTAANQ--CC 235
Query: 251 PVWSLPNYIALISGKDSCVNLNKEDVKKAVTILKKCAGYFHNFTLMAAC------DLDHC 304
P WSL NY+A++S + SC++ + D + + +L+ CA Y+H+ L+ +C C
Sbjct: 236 PSWSLGNYLAVLSNRSSCLDTTQADAARTLALLRTCALYYHSGALVPSCLGPGQNKSPRC 295
Query: 305 -NVPKYCTQHNAVYNLLFYLIDSEAFSPLNNAQKF--VKNTMLFLPLPRSDTVLPYY-KK 360
VP C+Q +A+Y LL +L+D + SP + +K ++LFLP P+ +++ Y +
Sbjct: 296 AQVPTKCSQSSAIYQLLHFLLDRDFLSPQTTDYQVPSLKYSLLFLPTPKGASLMDIYLDR 355
Query: 361 LENSNMSYDNLV-IPAIDFGLKNALFDIWIIEDTWLIALGGIFVFACVWIYTRSLILTLF 419
L DN + +D GLK L ++++DT L + +F + +Y RSL LTL
Sbjct: 356 LATPWGLADNYTSVTGMDLGLKQELLRHFLVQDTVYPLLALVAIFFGMALYLRSLFLTLM 415
Query: 420 LFAAITFSLGIAYFFYVYVFNLHFFPFMNLLVIVIVLGIGADDAFIYVKIWKMIGKQLIK 479
+ + SL +A+F Y F + +FPF+NL ++++ + A+ I+ +W++ QL
Sbjct: 416 VLLGVLGSLLVAFFLYQVAFRMAYFPFVNLAALLLLSSVCANHTLIFFDLWRLSKSQL-- 473
Query: 480 DNVVYQENGVLDINISSAGETILVQILEETMRHSIVTIFITTLTTAVAFYASYVSYIPAI 539
S G L Q + TM H + ++ LTT+ AFYASY+S +PA+
Sbjct: 474 ---------------PSGG---LAQRVGRTMHHFGYLLLVSGLTTSAAFYASYLSRLPAV 515
Query: 540 NCFSVFAGTAVLVNFVLMMTWLPISVFIVDVKLY-------------AKKKTFLDLVHKN 586
C ++F GTAVLV+ L + WLP S + + L + + L +H+
Sbjct: 516 RCLALFMGTAVLVHLALTLVWLPASAVLHERYLARGCARRARGRWEGSAPRRLLLALHRR 575
Query: 587 VNEMWE----NIRIVLNRFTIICVTKFHIAFVVVMGALGFISLVVVFYSPGLHLPDSKQ- 641
+ + R++ R V KF ++ AL + SP L LP
Sbjct: 576 LRGLRRAAAGTSRLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIAGVSPRLRLPTLPPP 635
Query: 642 -FQLFQTSHPFEQYEMQYRDKFLFERLSKDLGTGTKMPLRWVWGVKAIDNGNHMDPASKG 700
Q+F+ SHPFE+++ +YR FLFE+L + G G MP+ VWGV +D G+ +DP S
Sbjct: 636 GGQVFRPSHPFERFDAEYRQLFLFEQLPQ--GEGGHMPVVLVWGVLPVDTGDPLDPRSNS 693
Query: 701 HLVFDENFSISDPKSQSWLLGFCARIKGQPFYQQTLGPLLPN-CFIESFKMYMSRRCIDN 759
LV D FS S P++Q WLL C R + Q F+ TL P CF+E+ + +M +
Sbjct: 694 SLVRDPAFSASGPEAQRWLLALCHRARNQSFFD-TLQEGWPTLCFVETLQRWMES---PS 749
Query: 760 IDKINRSPCCETSKFPYKKEVFDFCIIKAMESLYQTPRELFMPGVAGPKFLRSAKPPIIA 819
++ CC S FP+ + F C+ M +L Q P G LR +A
Sbjct: 750 CARLGPDLCCGHSDFPWAPQFFLHCL--KMMALEQGPDGTQDLG------LRFDAHGSLA 801
Query: 820 ALVVEFESIVPYSLSYSEMNKFFTEVEKWTQTELENAPAGMKCGWFLSDFQFYDLQRTLA 879
ALV++F++ S Y++ F+ EV W EL AP G++ GWF S + Y LQ +L+
Sbjct: 802 ALVLQFQTNFRNSPDYNQTQLFYNEVSHWLAAELGMAPPGLRRGWFTSRLELYSLQHSLS 861
Query: 880 SGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLVINNWKLNILESVA 939
+ V L L+ AL F L+ T N S+ ++ A+ + +T+ +LV+ W+LN E++
Sbjct: 862 TEPAVVLGLALALAFATLLLGTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALF 921
Query: 940 ISTSAGLAVDFSLHYALSY-TNASGNKSARVKYXXXXXXXXXXXXXXXXGFAGVFLLRSN 998
+S S GL+VDF+++Y +SY ++ +RV + AGV +L +
Sbjct: 922 LSASVGLSVDFTVNYCISYHLCPHPDRLSRVAFSLRQTSCATAVGAAALFAAGVLMLPAT 981
Query: 999 LLPYSQIGAFLVLIMTVSWTYATFFLCSLLHIVG 1032
+L Y ++G L+++ VS +A+FF SL G
Sbjct: 982 VLLYRKLGIILMMVKCVSCGFASFFFQSLCCFFG 1015
Score = 48.0 bits (109), Expect = 2e-04
Identities = 25/78 (32%), Positives = 38/78 (48%)
Query: 1 MLAAYSRFIVRHSYLVLFTVSILSIVLTVIPLILHELPSFSDPIVGFETRGTTLAHRFIA 60
M +YS+ I VL + + T+ L+ LP FS P++GFE R T + + +
Sbjct: 57 MPKSYSQLIAEWPVAVLMLCLAVIFLCTLAGLLGARLPDFSKPLLGFEPRDTDIGSKLVV 116
Query: 61 WENLNDETRPSKRLAVNP 78
W L T P K L ++P
Sbjct: 117 WRALQALTGPRKLLFLSP 134
>AK026114-1|BAB15365.1| 917|Homo sapiens protein ( Homo sapiens cDNA:
FLJ22461 fis, clone HRC10107. ).
Length = 917
Score = 376 bits (925), Expect = e-103
Identities = 197/536 (36%), Positives = 316/536 (58%), Gaps = 28/536 (5%)
Query: 517 IFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISV-----FIVDV- 570
+F+T+ TTA AFYA+YVS I AI CF V+AGTA+LVN+VLM+TWLP V +++++
Sbjct: 1 MFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIF 60
Query: 571 --------KLYAKKKTFL---DLVHKNVNEMWENIRIVLNRFTIICVTKFHIAFVVVMGA 619
++Y K + HK + + E RI + V KF ++ A
Sbjct: 61 TCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLA 120
Query: 620 LGFISLVVVFYSPGLHLP--DSKQFQLFQTSHPFEQYEMQYRDKFLFERLSKDLGTGTKM 677
L +V +P + LP + +FQ+F++SHPFE+Y+ +Y+ F+FER+ G M
Sbjct: 121 LTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHH--GEELHM 178
Query: 678 PLRWVWGVKAIDNGNHMDPASKGHLVFDENFSISDPKSQSWLLGFCARIKGQPFYQQTLG 737
P+ +WGV DNGN ++P SKG L D +F+I+ P SQ+W+L FC +++ Q F+ QT
Sbjct: 179 PITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFFYQTDE 238
Query: 738 PLLPNCFIESFKMYMSRRCIDNIDKINRSPCCETSKFPYKKEVFDFCIIKAMESLYQTPR 797
+CFIE+FK +M + + D+ PCC FPYK+E+F+ CI +A+ L ++
Sbjct: 239 QDFTSCFIETFKQWMENQ---DCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTG 295
Query: 798 ELFMPGVAGPKFLRSAKPPIIAALVVEFESIVPYSLSYSEMNKFFTEVEKWTQTELENAP 857
GP+F + I A+V+EF+S ++L+Y +M++F+ EV+ W +EL +AP
Sbjct: 296 YHLDSKTPGPRFDIN---DTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAP 352
Query: 858 AGMKCGWFLSDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFS 917
G+ GWF+S+ +FYDLQ +L+ GT++A+ LS A+ F V++ T N + S+ A+ ++ +
Sbjct: 353 EGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGT 412
Query: 918 STVTIAVLVINNWKLNILESVAISTSAGLAVDFSLHYALSYTNA-SGNKSARVKYXXXXX 976
VT+ LV+ W+LN+LESV IS + GL+VDF++HY ++Y A ++ +V +
Sbjct: 413 IFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRV 472
Query: 977 XXXXXXXXXXXGFAGVFLLRSNLLPYSQIGAFLVLIMTVSWTYATFFLCSLLHIVG 1032
AG ++ S +L Y+Q+G F++LIM +SW +ATFF + +G
Sbjct: 473 GSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLG 528
>AK023679-1|BAB14637.1| 637|Homo sapiens protein ( Homo sapiens cDNA
FLJ13617 fis, clone PLACE1010917. ).
Length = 637
Score = 279 bits (685), Expect = 3e-74
Identities = 133/357 (37%), Positives = 217/357 (60%), Gaps = 7/357 (1%)
Query: 677 MPLRWVWGVKAIDNGNHMDPASKGHLVFDENFSISDPKSQSWLLGFCARIKGQPFYQQTL 736
MP+ +WGV DNGN ++P SKG L D +F+I+ P SQ+W+L FC +++ Q F+ QT
Sbjct: 1 MPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFFYQTD 60
Query: 737 GPLLPNCFIESFKMYMSRRCIDNIDKINRSPCCETSKFPYKKEVFDFCIIKAMESLYQTP 796
+CFIE+FK +M + + D+ PCC FPYK+E+F+ CI +A+ L ++
Sbjct: 61 EQDFTSCFIETFKQWMENQ---DCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERST 117
Query: 797 RELFMPGVAGPKFLRSAKPPIIAALVVEFESIVPYSLSYSEMNKFFTEVEKWTQTELENA 856
GP+F + I A+V+EF+S ++L+Y +M++F+ EV+ W +EL +A
Sbjct: 118 GYHLDSKTPGPRFDIN---DTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSA 174
Query: 857 PAGMKCGWFLSDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIF 916
P G+ GWF+S+ +FYDLQ +L+ GT++A+ LS A+ F V++ T N + S+ A+ ++
Sbjct: 175 PEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAG 234
Query: 917 SSTVTIAVLVINNWKLNILESVAISTSAGLAVDFSLHYALSYTNA-SGNKSARVKYXXXX 975
+ VT+ LV+ W+LN+LESV IS + GL+VDF++HY ++Y A ++ +V +
Sbjct: 235 TIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSR 294
Query: 976 XXXXXXXXXXXXGFAGVFLLRSNLLPYSQIGAFLVLIMTVSWTYATFFLCSLLHIVG 1032
AG ++ S +L Y+Q+G F++LIM +SW +ATFF + +G
Sbjct: 295 VGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLG 351
>BC007734-1|AAH07734.1| 542|Homo sapiens DISP1 protein protein.
Length = 542
Score = 139 bits (336), Expect = 6e-32
Identities = 86/280 (30%), Positives = 142/280 (50%), Gaps = 15/280 (5%)
Query: 161 KDHSRKQWLSLKNMQRIADKPINLNYASGTCGPPISDYAHLVITNTDNSSLLSYKNVERL 220
K H +W + + N + S C P Y+ +V T++ +L + ++ +
Sbjct: 263 KSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSM 322
Query: 221 CKFQSXXXXXXXXXXXXXCQRTTHSEDICCPVWSLPNYIALISGKDSCVNLNKEDVKKAV 280
C + CQRTT + CCP W+L NYIA+++ + SC + + DV +
Sbjct: 323 CNVDNSRIRSHPQFGDL-CQRTTAAS--CCPSWTLGNYIAILNNRSSCQKIVERDVSHTL 379
Query: 281 TILKKCAGYFHNFTL------MAACDLDH--C-NVPKYCTQHNAVYNLLFYLIDSEAFSP 331
+L+ CA ++ N TL MAA D C NVP+ CT++NAVY +L YL+D + +P
Sbjct: 380 KLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTP 439
Query: 332 --LNNAQKFVKNTMLFLPLPRSDTVLP-YYKKLENSNMSYDNLVIPAIDFGLKNALFDIW 388
+ A +K +MLF P + ++++ Y EN N S I I+FG+K++LF +
Sbjct: 440 KTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTITGIEFGIKHSLFQDY 499
Query: 389 IIEDTWLIALGGIFVFACVWIYTRSLILTLFLFAAITFSL 428
++ DT A+ + V + +YT+S+ +TL AI SL
Sbjct: 500 LLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSL 539
Score = 57.6 bits (133), Expect = 2e-07
Identities = 28/87 (32%), Positives = 48/87 (55%), Gaps = 1/87 (1%)
Query: 4 AYSRFIVRHSYLVLFTVSILSIVLTVIPLILHELPSFSDPIVGFETRGTTLAHRFIAWEN 63
+Y+ I +VL ++ +V ++ +++ ELP FSDP++GFE RGT + R + W N
Sbjct: 180 SYAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNN 239
Query: 64 LNDETRPSKRLAVNP-KEIEDQIRMNR 89
+ T LA P K ++Q + +R
Sbjct: 240 MVKNTGYKATLANYPFKYADEQAKSHR 266
>AK098669-1|BAC05373.1| 542|Homo sapiens protein ( Homo sapiens
cDNA FLJ25803 fis, clone TST07160. ).
Length = 542
Score = 139 bits (336), Expect = 6e-32
Identities = 86/280 (30%), Positives = 142/280 (50%), Gaps = 15/280 (5%)
Query: 161 KDHSRKQWLSLKNMQRIADKPINLNYASGTCGPPISDYAHLVITNTDNSSLLSYKNVERL 220
K H +W + + N + S C P Y+ +V T++ +L + ++ +
Sbjct: 263 KSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSM 322
Query: 221 CKFQSXXXXXXXXXXXXXCQRTTHSEDICCPVWSLPNYIALISGKDSCVNLNKEDVKKAV 280
C + CQRTT + CCP W+L NYIA+++ + SC + + DV +
Sbjct: 323 CNVDNSRIRSHPQFGDL-CQRTTAAS--CCPSWTLGNYIAILNNRSSCQKIVERDVSHTL 379
Query: 281 TILKKCAGYFHNFTL------MAACDLDH--C-NVPKYCTQHNAVYNLLFYLIDSEAFSP 331
+L+ CA ++ N TL MAA D C NVP+ CT++NAVY +L YL+D + +P
Sbjct: 380 KLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTP 439
Query: 332 --LNNAQKFVKNTMLFLPLPRSDTVLP-YYKKLENSNMSYDNLVIPAIDFGLKNALFDIW 388
+ A +K +MLF P + ++++ Y EN N S I I+FG+K++LF +
Sbjct: 440 KTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTITGIEFGIKHSLFQDY 499
Query: 389 IIEDTWLIALGGIFVFACVWIYTRSLILTLFLFAAITFSL 428
++ DT A+ + V + +YT+S+ +TL AI SL
Sbjct: 500 LLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSL 539
Score = 57.6 bits (133), Expect = 2e-07
Identities = 28/87 (32%), Positives = 48/87 (55%), Gaps = 1/87 (1%)
Query: 4 AYSRFIVRHSYLVLFTVSILSIVLTVIPLILHELPSFSDPIVGFETRGTTLAHRFIAWEN 63
+Y+ I +VL ++ +V ++ +++ ELP FSDP++GFE RGT + R + W N
Sbjct: 180 SYAALIADWPVVVLGICTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNN 239
Query: 64 LNDETRPSKRLAVNP-KEIEDQIRMNR 89
+ T LA P K ++Q + +R
Sbjct: 240 MVKNTGYKATLANYPFKYADEQAKSHR 266
>AL590989-2|CAH70606.1| 1438|Homo sapiens patched domain containing
2 protein.
Length = 1438
Score = 56.0 bits (129), Expect = 7e-07
Identities = 46/196 (23%), Positives = 90/196 (45%), Gaps = 24/196 (12%)
Query: 392 DTWLIALGGIFVFACVWIYTR-SLILTLFLFAAITFSLGIAYFFYVYVFNLHFFPFMNLL 450
D L + + A V+I T S+ L+ F A+I S +A F Y VF + + +N +
Sbjct: 508 DMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGV 567
Query: 451 VIVIVLGIGADDAFIYVKIWKMIGKQLIKDNVVYQENGVLDINISSAGETILVQILEETM 510
+++GIG DD F+++ ++ ++D + + + +AG+
Sbjct: 568 AAFVIVGIGVDDVFVFINTYRQATH--LEDPQLRMIH-----TVQTAGK----------- 609
Query: 511 RHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFIVDV 570
F T+LTTA A+ A+ S IPA++ F +F V ++ ++ +P ++ + +
Sbjct: 610 -----ATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSL 664
Query: 571 KLYAKKKTFLDLVHKN 586
L + + H+N
Sbjct: 665 YLAPLESSCQTSCHQN 680
Score = 35.9 bits (79), Expect = 0.81
Identities = 17/86 (19%), Positives = 40/86 (46%), Gaps = 4/86 (4%)
Query: 883 IVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSST----VTIAVLVINNWKLNILESV 938
+ + L L ++ + A F T + L ++ S + + ++ + W++ +E++
Sbjct: 1226 VQSALCGLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAI 1285
Query: 939 AISTSAGLAVDFSLHYALSYTNASGN 964
++S G +VD+ +H Y A N
Sbjct: 1286 SLSILVGSSVDYCVHLVEGYLLAGEN 1311
>AL117236-1|CAB55303.1| 594|Homo sapiens hypothetical protein
protein.
Length = 594
Score = 56.0 bits (129), Expect = 7e-07
Identities = 46/196 (23%), Positives = 90/196 (45%), Gaps = 24/196 (12%)
Query: 392 DTWLIALGGIFVFACVWIYTR-SLILTLFLFAAITFSLGIAYFFYVYVFNLHFFPFMNLL 450
D L + + A V+I T S+ L+ F A+I S +A F Y VF + + +N +
Sbjct: 123 DMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGV 182
Query: 451 VIVIVLGIGADDAFIYVKIWKMIGKQLIKDNVVYQENGVLDINISSAGETILVQILEETM 510
+++GIG DD F+++ ++ ++D + + + +AG+
Sbjct: 183 AAFVIVGIGVDDVFVFINTYRQATH--LEDPQLRMIH-----TVQTAGK----------- 224
Query: 511 RHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFIVDV 570
F T+LTTA A+ A+ S IPA++ F +F V ++ ++ +P ++ + +
Sbjct: 225 -----ATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSL 279
Query: 571 KLYAKKKTFLDLVHKN 586
L + + H+N
Sbjct: 280 YLAPLESSCQTSCHQN 295
>AL031735-1|CAI22474.1| 1438|Homo sapiens patched domain containing
2 protein.
Length = 1438
Score = 56.0 bits (129), Expect = 7e-07
Identities = 46/196 (23%), Positives = 90/196 (45%), Gaps = 24/196 (12%)
Query: 392 DTWLIALGGIFVFACVWIYTR-SLILTLFLFAAITFSLGIAYFFYVYVFNLHFFPFMNLL 450
D L + + A V+I T S+ L+ F A+I S +A F Y VF + + +N +
Sbjct: 508 DMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGV 567
Query: 451 VIVIVLGIGADDAFIYVKIWKMIGKQLIKDNVVYQENGVLDINISSAGETILVQILEETM 510
+++GIG DD F+++ ++ ++D + + + +AG+
Sbjct: 568 AAFVIVGIGVDDVFVFINTYRQATH--LEDPQLRMIH-----TVQTAGK----------- 609
Query: 511 RHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFIVDV 570
F T+LTTA A+ A+ S IPA++ F +F V ++ ++ +P ++ + +
Sbjct: 610 -----ATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSL 664
Query: 571 KLYAKKKTFLDLVHKN 586
L + + H+N
Sbjct: 665 YLAPLESSCQTSCHQN 680
Score = 35.9 bits (79), Expect = 0.81
Identities = 17/86 (19%), Positives = 40/86 (46%), Gaps = 4/86 (4%)
Query: 883 IVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSST----VTIAVLVINNWKLNILESV 938
+ + L L ++ + A F T + L ++ S + + ++ + W++ +E++
Sbjct: 1226 VQSALCGLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAI 1285
Query: 939 AISTSAGLAVDFSLHYALSYTNASGN 964
++S G +VD+ +H Y A N
Sbjct: 1286 SLSILVGSSVDYCVHLVEGYLLAGEN 1311
>AB037758-1|BAA92575.1| 1438|Homo sapiens KIAA1337 protein protein.
Length = 1438
Score = 56.0 bits (129), Expect = 7e-07
Identities = 46/196 (23%), Positives = 90/196 (45%), Gaps = 24/196 (12%)
Query: 392 DTWLIALGGIFVFACVWIYTR-SLILTLFLFAAITFSLGIAYFFYVYVFNLHFFPFMNLL 450
D L + + A V+I T S+ L+ F A+I S +A F Y VF + + +N +
Sbjct: 508 DMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGV 567
Query: 451 VIVIVLGIGADDAFIYVKIWKMIGKQLIKDNVVYQENGVLDINISSAGETILVQILEETM 510
+++GIG DD F+++ ++ ++D + + + +AG+
Sbjct: 568 AAFVIVGIGVDDVFVFINTYRQATH--LEDPQLRMIH-----TVQTAGK----------- 609
Query: 511 RHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFIVDV 570
F T+LTTA A+ A+ S IPA++ F +F V ++ ++ +P ++ + +
Sbjct: 610 -----ATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSL 664
Query: 571 KLYAKKKTFLDLVHKN 586
L + + H+N
Sbjct: 665 YLAPLESSCQTSCHQN 680
Score = 35.9 bits (79), Expect = 0.81
Identities = 17/86 (19%), Positives = 40/86 (46%), Gaps = 4/86 (4%)
Query: 883 IVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSST----VTIAVLVINNWKLNILESV 938
+ + L L ++ + A F T + L ++ S + + ++ + W++ +E++
Sbjct: 1226 VQSALCGLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAI 1285
Query: 939 AISTSAGLAVDFSLHYALSYTNASGN 964
++S G +VD+ +H Y A N
Sbjct: 1286 SLSILVGSSVDYCVHLVEGYLLAGEN 1311
>BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, type
C1 protein.
Length = 1278
Score = 50.0 bits (114), Expect = 5e-05
Identities = 27/80 (33%), Positives = 49/80 (61%), Gaps = 2/80 (2%)
Query: 498 GETILVQILEETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLM 557
GET L Q L + ++F+++ + VAF+ +S +PA++ FS+FAG AV ++F+L
Sbjct: 717 GET-LDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQ 775
Query: 558 MTWLPISVFIVDVKLYAKKK 577
+T +S+ +D+K K +
Sbjct: 776 ITCF-VSLLGLDIKRQEKNR 794
>AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1
protein protein.
Length = 1278
Score = 50.0 bits (114), Expect = 5e-05
Identities = 27/80 (33%), Positives = 49/80 (61%), Gaps = 2/80 (2%)
Query: 498 GETILVQILEETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLM 557
GET L Q L + ++F+++ + VAF+ +S +PA++ FS+FAG AV ++F+L
Sbjct: 717 GET-LDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQ 775
Query: 558 MTWLPISVFIVDVKLYAKKK 577
+T +S+ +D+K K +
Sbjct: 776 ITCF-VSLLGLDIKRQEKNR 794
>AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein
protein.
Length = 1278
Score = 50.0 bits (114), Expect = 5e-05
Identities = 27/80 (33%), Positives = 49/80 (61%), Gaps = 2/80 (2%)
Query: 498 GETILVQILEETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLM 557
GET L Q L + ++F+++ + VAF+ +S +PA++ FS+FAG AV ++F+L
Sbjct: 717 GET-LDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQ 775
Query: 558 MTWLPISVFIVDVKLYAKKK 577
+T +S+ +D+K K +
Sbjct: 776 ITCF-VSLLGLDIKRQEKNR 794
>AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease
protein protein.
Length = 1278
Score = 50.0 bits (114), Expect = 5e-05
Identities = 27/80 (33%), Positives = 49/80 (61%), Gaps = 2/80 (2%)
Query: 498 GETILVQILEETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLM 557
GET L Q L + ++F+++ + VAF+ +S +PA++ FS+FAG AV ++F+L
Sbjct: 717 GET-LDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQ 775
Query: 558 MTWLPISVFIVDVKLYAKKK 577
+T +S+ +D+K K +
Sbjct: 776 ITCF-VSLLGLDIKRQEKNR 794
>AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, type
C1 variant protein.
Length = 1289
Score = 50.0 bits (114), Expect = 5e-05
Identities = 27/80 (33%), Positives = 49/80 (61%), Gaps = 2/80 (2%)
Query: 498 GETILVQILEETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLM 557
GET L Q L + ++F+++ + VAF+ +S +PA++ FS+FAG AV ++F+L
Sbjct: 728 GET-LDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQ 786
Query: 558 MTWLPISVFIVDVKLYAKKK 577
+T +S+ +D+K K +
Sbjct: 787 ITCF-VSLLGLDIKRQEKNR 805
>U59464-1|AAC50550.1| 1447|Homo sapiens PATCHED protein.
Length = 1447
Score = 39.1 bits (87), Expect = 0.087
Identities = 19/75 (25%), Positives = 42/75 (56%), Gaps = 3/75 (4%)
Query: 508 ETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFI 567
E ++ + ++ +T+++ AF+ + + IPA+ FS+ A V+ NF +++ P I
Sbjct: 539 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPA---I 595
Query: 568 VDVKLYAKKKTFLDL 582
+ + LY ++ LD+
Sbjct: 596 LSMDLYRREDRRLDI 610
Score = 36.7 bits (81), Expect = 0.46
Identities = 23/100 (23%), Positives = 48/100 (48%)
Query: 869 FQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLVIN 928
F F++ L ++ + + A F+V LN T+ + + + ++ +
Sbjct: 1015 FLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLI 1074
Query: 929 NWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSAR 968
KL+ + V + S G+ V+F++H AL++ A G+K+ R
Sbjct: 1075 GIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRR 1114
>U43148-1|AAC50496.1| 1296|Homo sapiens PTC protein.
Length = 1296
Score = 39.1 bits (87), Expect = 0.087
Identities = 19/75 (25%), Positives = 42/75 (56%), Gaps = 3/75 (4%)
Query: 508 ETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFI 567
E ++ + ++ +T+++ AF+ + + IPA+ FS+ A V+ NF +++ P I
Sbjct: 388 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPA---I 444
Query: 568 VDVKLYAKKKTFLDL 582
+ + LY ++ LD+
Sbjct: 445 LSMDLYRREDRRLDI 459
Score = 34.3 bits (75), Expect = 2.5
Identities = 22/100 (22%), Positives = 47/100 (47%)
Query: 869 FQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLVIN 928
F F++ L ++ + + A F+V LN T+ + + + ++ +
Sbjct: 864 FLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLI 923
Query: 929 NWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSAR 968
KL+ + V + S G+ V+F++H AL++ A +K+ R
Sbjct: 924 GIKLSAVPVVILIASVGIGVEFTVHVALAFLTAISDKNRR 963
>AL161729-2|CAH73818.1| 1296|Homo sapiens patched homolog 1
(Drosophila) protein.
Length = 1296
Score = 39.1 bits (87), Expect = 0.087
Identities = 19/75 (25%), Positives = 42/75 (56%), Gaps = 3/75 (4%)
Query: 508 ETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFI 567
E ++ + ++ +T+++ AF+ + + IPA+ FS+ A V+ NF +++ P I
Sbjct: 388 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPA---I 444
Query: 568 VDVKLYAKKKTFLDL 582
+ + LY ++ LD+
Sbjct: 445 LSMDLYRREDRRLDI 459
Score = 36.7 bits (81), Expect = 0.46
Identities = 23/100 (23%), Positives = 48/100 (48%)
Query: 869 FQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLVIN 928
F F++ L ++ + + A F+V LN T+ + + + ++ +
Sbjct: 864 FLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLI 923
Query: 929 NWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSAR 968
KL+ + V + S G+ V+F++H AL++ A G+K+ R
Sbjct: 924 GIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRR 963
>AL161729-1|CAH73817.1| 1447|Homo sapiens patched homolog 1
(Drosophila) protein.
Length = 1447
Score = 39.1 bits (87), Expect = 0.087
Identities = 19/75 (25%), Positives = 42/75 (56%), Gaps = 3/75 (4%)
Query: 508 ETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFI 567
E ++ + ++ +T+++ AF+ + + IPA+ FS+ A V+ NF +++ P I
Sbjct: 539 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPA---I 595
Query: 568 VDVKLYAKKKTFLDL 582
+ + LY ++ LD+
Sbjct: 596 LSMDLYRREDRRLDI 610
Score = 36.7 bits (81), Expect = 0.46
Identities = 23/100 (23%), Positives = 48/100 (48%)
Query: 869 FQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLVIN 928
F F++ L ++ + + A F+V LN T+ + + + ++ +
Sbjct: 1015 FLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLI 1074
Query: 929 NWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSAR 968
KL+ + V + S G+ V+F++H AL++ A G+K+ R
Sbjct: 1075 GIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRR 1114
>AB233422-1|BAE45302.1| 348|Homo sapiens PTCH protein -10 protein.
Length = 348
Score = 39.1 bits (87), Expect = 0.087
Identities = 19/75 (25%), Positives = 42/75 (56%), Gaps = 3/75 (4%)
Query: 508 ETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFI 567
E ++ + ++ +T+++ AF+ + + IPA+ FS+ A V+ NF +++ P I
Sbjct: 200 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPA---I 256
Query: 568 VDVKLYAKKKTFLDL 582
+ + LY ++ LD+
Sbjct: 257 LSMDLYRREDRRLDI 271
>AY395768-1|AAR21239.1| 651|Homo sapiens patched protein.
Length = 651
Score = 37.9 bits (84), Expect = 0.20
Identities = 18/75 (24%), Positives = 42/75 (56%), Gaps = 3/75 (4%)
Query: 508 ETMRHSIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMTWLPISVFI 567
E ++ + ++ +T+++ AF+ + + IPA+ FS+ A ++ NF +++ P I
Sbjct: 134 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVLVFNFAMVLLIFPA---I 190
Query: 568 VDVKLYAKKKTFLDL 582
+ + LY ++ LD+
Sbjct: 191 LSMDLYRREDRRLDI 205
>AK127397-1|BAC86958.1| 130|Homo sapiens protein ( Homo sapiens
cDNA FLJ45488 fis, clone BRTHA2003759. ).
Length = 130
Score = 37.5 bits (83), Expect = 0.27
Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 9/90 (10%)
Query: 401 IFVFACVWIYTRSLILT---LFLFAAITFSLGIAYFFYVYVFN-----LHFFPFMNLLVI 452
I+V+ +++Y I T L++F I L I + Y+Y+F LH F ++++ +
Sbjct: 27 IYVYVYIYLYIYFYIFTYIYLYIFIYIYICLYIYLYIYLYIFTYIYIYLHIFIYLHIFIY 86
Query: 453 VIVLGIGADDAFIYVKIWKMIGKQLIKDNV 482
+ + FIY+ I+ M G Q I N+
Sbjct: 87 ICICLYIFIYVFIYINIY-MRGLQNIHGNI 115
>AK126025-1|BAC86399.1| 804|Homo sapiens protein ( Homo sapiens
cDNA FLJ44037 fis, clone TESTI4028823. ).
Length = 804
Score = 37.5 bits (83), Expect = 0.27
Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 23/106 (21%)
Query: 454 IVLGIGADDAFIYVKIWKMIGKQLIKDNVVYQENGVLDINISSAGETILVQILEETMRHS 513
++LG+G DD FI + W K N+ AG+ + + + +
Sbjct: 450 LILGVGVDDMFIMISAWH-------KTNL--------------AGD--IRERMSNVYSKA 486
Query: 514 IVTIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMT 559
V+I ITT+T +A Y +S ++ CF ++ GT +L + +T
Sbjct: 487 AVSITITTITNILALYTGIMSSFRSVQCFCIYTGTTLLFCYFYNIT 532
>AY438664-1|AAR05447.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 37.1 bits (82), Expect = 0.35
Identities = 22/105 (20%), Positives = 47/105 (44%)
Query: 867 SDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLV 926
S F F++ L ++A+ + F+V LN T+ + + + ++
Sbjct: 949 SPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMG 1008
Query: 927 INNWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSARVKY 971
KL+ + V + S G+ V+F++H AL + G+++ R +
Sbjct: 1009 FLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAH 1053
>AY359016-1|AAQ89375.1| 1203|Homo sapiens Patched 2 protein.
Length = 1203
Score = 37.1 bits (82), Expect = 0.35
Identities = 22/105 (20%), Positives = 47/105 (44%)
Query: 867 SDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLV 926
S F F++ L ++A+ + F+V LN T+ + + + ++
Sbjct: 949 SPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMG 1008
Query: 927 INNWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSARVKY 971
KL+ + V + S G+ V+F++H AL + G+++ R +
Sbjct: 1009 FLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAH 1053
>AY358555-1|AAQ88919.1| 1211|Homo sapiens Patched 2 protein.
Length = 1211
Score = 37.1 bits (82), Expect = 0.35
Identities = 22/105 (20%), Positives = 47/105 (44%)
Query: 867 SDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLV 926
S F F++ L ++A+ + F+V LN T+ + + + ++
Sbjct: 949 SPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMG 1008
Query: 927 INNWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSARVKY 971
KL+ + V + S G+ V+F++H AL + G+++ R +
Sbjct: 1009 FLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAH 1053
>AL592166-5|CAI13000.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 37.1 bits (82), Expect = 0.35
Identities = 22/105 (20%), Positives = 47/105 (44%)
Query: 867 SDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLV 926
S F F++ L ++A+ + F+V LN T+ + + + ++
Sbjct: 949 SPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMG 1008
Query: 927 INNWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSARVKY 971
KL+ + V + S G+ V+F++H AL + G+++ R +
Sbjct: 1009 FLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAH 1053
>AL136380-1|CAI23127.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 37.1 bits (82), Expect = 0.35
Identities = 22/105 (20%), Positives = 47/105 (44%)
Query: 867 SDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLV 926
S F F++ L ++A+ + F+V LN T+ + + + ++
Sbjct: 949 SPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMG 1008
Query: 927 INNWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSARVKY 971
KL+ + V + S G+ V+F++H AL + G+++ R +
Sbjct: 1009 FLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAH 1053
>AF119569-1|AAD17260.1| 1146|Homo sapiens patched 2 protein.
Length = 1146
Score = 37.1 bits (82), Expect = 0.35
Identities = 22/105 (20%), Positives = 47/105 (44%)
Query: 867 SDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLV 926
S F F++ L ++A+ + F+V LN T+ + + + ++
Sbjct: 949 SPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMG 1008
Query: 927 INNWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSARVKY 971
KL+ + V + S G+ V+F++H AL + G+++ R +
Sbjct: 1009 FLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAH 1053
>AF091501-1|AAC79847.1| 1203|Homo sapiens receptor protein patched 2
protein.
Length = 1203
Score = 37.1 bits (82), Expect = 0.35
Identities = 22/105 (20%), Positives = 47/105 (44%)
Query: 867 SDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLV 926
S F F++ L ++A+ + F+V LN T+ + + + ++
Sbjct: 949 SPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMG 1008
Query: 927 INNWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSARVKY 971
KL+ + V + S G+ V+F++H AL + G+++ R +
Sbjct: 1009 FLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAH 1053
>AF087651-1|AAD25953.1| 1203|Homo sapiens patched 2 protein.
Length = 1203
Score = 37.1 bits (82), Expect = 0.35
Identities = 22/105 (20%), Positives = 47/105 (44%)
Query: 867 SDFQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLV 926
S F F++ L ++A+ + F+V LN T+ + + + ++
Sbjct: 949 SPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMG 1008
Query: 927 INNWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSARVKY 971
KL+ + V + S G+ V+F++H AL + G+++ R +
Sbjct: 1009 FLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAH 1053
>AB209495-1|BAD92732.1| 586|Homo sapiens patched variant protein.
Length = 586
Score = 36.7 bits (81), Expect = 0.46
Identities = 23/100 (23%), Positives = 48/100 (48%)
Query: 869 FQFYDLQRTLASGTIVALLLSAALGFIVLIPATLNFVTSVCALTAMIFSSTVTIAVLVIN 928
F F++ L ++ + + A F+V LN T+ + + + ++ +
Sbjct: 451 FLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLI 510
Query: 929 NWKLNILESVAISTSAGLAVDFSLHYALSYTNASGNKSAR 968
KL+ + V + S G+ V+F++H AL++ A G+K+ R
Sbjct: 511 GIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRR 550
>BC107139-1|AAI07140.1| 767|Homo sapiens patched domain containing
3 protein.
Length = 767
Score = 35.5 bits (78), Expect = 1.1
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 4/72 (5%)
Query: 492 INISSAGETILVQILEETMRH----SIVTIFITTLTTAVAFYASYVSYIPAINCFSVFAG 547
I IS+ +T L + E M + + V+I ITT+T +A Y +S ++ CF ++ G
Sbjct: 461 IMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTG 520
Query: 548 TAVLVNFVLMMT 559
+L + +T
Sbjct: 521 MTLLFCYFYNIT 532
>BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein.
Length = 1332
Score = 34.3 bits (75), Expect = 2.5
Identities = 12/44 (27%), Positives = 31/44 (70%)
Query: 516 TIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMT 559
++ + +L+ A+ F+ ++ +PA+ F++ +G AV+++F+L M+
Sbjct: 746 SMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMS 789
>AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant
protein.
Length = 1332
Score = 34.3 bits (75), Expect = 2.5
Identities = 12/44 (27%), Positives = 31/44 (70%)
Query: 516 TIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMT 559
++ + +L+ A+ F+ ++ +PA+ F++ +G AV+++F+L M+
Sbjct: 746 SMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMS 789
>AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1
protein.
Length = 1332
Score = 34.3 bits (75), Expect = 2.5
Identities = 12/44 (27%), Positives = 31/44 (70%)
Query: 516 TIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMT 559
++ + +L+ A+ F+ ++ +PA+ F++ +G AV+++F+L M+
Sbjct: 746 SMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMS 789
>AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like
protein 1 protein.
Length = 1359
Score = 34.3 bits (75), Expect = 2.5
Identities = 12/44 (27%), Positives = 31/44 (70%)
Query: 516 TIFITTLTTAVAFYASYVSYIPAINCFSVFAGTAVLVNFVLMMT 559
++ + +L+ A+ F+ ++ +PA+ F++ +G AV+++F+L M+
Sbjct: 746 SMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMS 789
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.324 0.138 0.422
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 156,807,024
Number of Sequences: 224733
Number of extensions: 6573890
Number of successful extensions: 24299
Number of sequences better than 10.0: 37
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 24166
Number of HSP's gapped (non-prelim): 110
length of query: 1118
length of database: 73,234,838
effective HSP length: 98
effective length of query: 1020
effective length of database: 51,211,004
effective search space: 52235224080
effective search space used: 52235224080
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.6 bits)
S2: 70 (32.3 bits)
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