Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000467-TA|BGIBMGA000467-PA|IPR002126|Cadherin,
IPR006209|EGF-like, IPR012680|Laminin G, subdomain 2,
IPR002049|EGF-like, laminin, IPR001879|Hormone receptor,
extracellular, IPR000203|GPS, IPR000152|Aspartic acid and asparagine
hydroxylation site, IPR013032|EGF-like region,
IPR000005|Helix-turn-helix, AraC type, IPR000083|Fibronectin, type I,
IPR006210|EGF, IPR001791|Laminin G, IPR001881|EGF-like
calcium-binding, IPR000742|EGF-like, type 3
(2796 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AL031597-2|CAI23555.1| 3014|Homo sapiens cadherin, EGF LAG seven... 922 0.0
AL031588-3|CAI19319.1| 3014|Homo sapiens cadherin, EGF LAG seven... 922 0.0
AL021392-2|CAI20967.1| 3014|Homo sapiens cadherin, EGF LAG seven... 922 0.0
AF231024-1|AAF61930.1| 3014|Homo sapiens protocadherin Flamingo ... 922 0.0
AY714129-1|AAU94938.1| 4186|Homo sapiens anchor protein protein. 903 0.0
AF231023-1|AAF61929.1| 3312|Homo sapiens protocadherin Flamingo ... 903 0.0
D87469-1|BAA13407.2| 2854|Homo sapiens KIAA0279 protein protein. 901 0.0
AL390252-1|CAI13170.1| 2923|Homo sapiens cadherin, EGF LAG seven... 901 0.0
AF234887-1|AAG00080.1| 2923|Homo sapiens FLAMINGO 1 protein. 901 0.0
AB065955-1|BAC06168.1| 2923|Homo sapiens seven transmembrane hel... 901 0.0
BC000059-1|AAH00059.2| 771|Homo sapiens CELSR1 protein protein. 702 0.0
X87241-1|CAA60685.1| 4590|Homo sapiens homologue of Drosophila F... 459 e-128
AY356402-1|AAR13653.1| 3222|Homo sapiens fat-like cadherin FATJ ... 397 e-109
AL772287-2|CAI13626.1| 3359|Homo sapiens cadherin-like 23 protein. 355 1e-96
AL731541-6|CAI40841.1| 3359|Homo sapiens cadherin-like 23 protein. 355 1e-96
AL359183-3|CAI13426.1| 3359|Homo sapiens cadherin-like 23 protein. 355 1e-96
AY010111-1|AAG27034.2| 3354|Homo sapiens cadherin 23 protein. 355 2e-96
AF312024-1|AAG48303.1| 3354|Homo sapiens cadherin related 23 pro... 355 2e-96
AY354497-1|AAR10443.1| 2916|Homo sapiens cadherin protein protein. 352 9e-96
AB011536-1|BAA32464.1| 1364|Homo sapiens MEGF2 protein. 343 4e-93
AF231022-1|AAF61928.1| 4349|Homo sapiens protocadherin Fat 2 pro... 339 9e-92
BC065284-1|AAH65284.1| 1381|Homo sapiens CDH23 protein protein. 338 2e-91
AB053446-1|BAB61903.2| 3434|Homo sapiens KIAA1773 protein protein. 314 4e-84
AB075518-1|BAE45762.1| 656|Homo sapiens putative protein produc... 309 8e-83
AL772287-1|CAI13625.2| 1066|Homo sapiens cadherin-like 23 protein. 301 3e-80
AL731541-5|CAM20296.1| 1066|Homo sapiens cadherin-like 23 protein. 301 3e-80
AL359183-2|CAI13425.2| 1066|Homo sapiens cadherin-like 23 protein. 301 3e-80
BC032581-1|AAH32581.1| 1061|Homo sapiens CDH23 protein protein. 298 2e-79
AB058715-1|BAB47441.1| 803|Homo sapiens KIAA1812 protein protein. 297 3e-79
L11370-1|AAA36419.1| 1026|Homo sapiens protocadherin 42 protein. 294 3e-78
AK127704-1|BAC87093.1| 1366|Homo sapiens protein ( Homo sapiens ... 290 6e-77
AY861435-1|AAX56125.1| 1065|Homo sapiens protocadherin 11X isofo... 281 3e-74
AY861434-1|AAX56124.1| 1329|Homo sapiens protocadherin 11X isofo... 281 3e-74
AY861433-1|AAX56123.1| 1310|Homo sapiens protocadherin 11X isofo... 281 3e-74
AY861432-1|AAX56122.1| 1339|Homo sapiens protocadherin 11X isofo... 281 3e-74
AL133321-2|CAI41436.1| 1337|Homo sapiens protocadherin 11 X-link... 281 3e-74
AL133321-1|CAI41435.1| 1347|Homo sapiens protocadherin 11 X-link... 281 3e-74
AL133274-3|CAI41629.1| 1310|Homo sapiens protocadherin 11 X-link... 281 3e-74
AL133274-2|CAI41631.1| 1337|Homo sapiens protocadherin 11 X-link... 281 3e-74
AL133274-1|CAI41630.1| 1347|Homo sapiens protocadherin 11 X-link... 281 3e-74
AL121869-5|CAI41414.1| 1337|Homo sapiens protocadherin 11 X-link... 281 3e-74
AL121869-4|CAI41413.1| 1347|Homo sapiens protocadherin 11 X-link... 281 3e-74
AL121869-3|CAI41412.1| 1310|Homo sapiens protocadherin 11 X-link... 281 3e-74
AJ276804-1|CAC13123.1| 1025|Homo sapiens protocadherin protein. 281 3e-74
AF332219-1|AAK13471.1| 1337|Homo sapiens protocadherin 11 protein. 281 3e-74
AF332218-1|AAK13470.1| 1347|Homo sapiens protocadherin 11 protein. 281 3e-74
AB026187-1|BAA90765.1| 1021|Homo sapiens protocadherin-Xa protein. 281 3e-74
BX537422-1|CAD97664.1| 1203|Homo sapiens hypothetical protein pr... 280 4e-74
AL603863-3|CAM17491.1| 1237|Homo sapiens protocadherin 9 protein. 280 4e-74
AL603863-2|CAH72759.1| 1203|Homo sapiens protocadherin 9 protein. 280 4e-74
AL603863-1|CAH72758.1| 1032|Homo sapiens protocadherin 9 protein. 280 4e-74
AL355173-2|CAH72612.1| 1203|Homo sapiens protocadherin 9 protein. 280 4e-74
AL355173-1|CAM17290.1| 1237|Homo sapiens protocadherin 9 protein. 280 4e-74
AL138814-1|CAM13066.1| 1237|Homo sapiens protocadherin 9 protein. 280 4e-74
AL136999-2|CAI12502.1| 1203|Homo sapiens protocadherin 9 protein. 280 4e-74
AL136999-1|CAM13771.1| 1237|Homo sapiens protocadherin 9 protein. 280 4e-74
AF169692-1|AAF89689.2| 1203|Homo sapiens protocadherin-9 protein. 280 4e-74
AJ276803-1|CAC13122.1| 1037|Homo sapiens protocadherin protein. 278 2e-73
AF332217-1|AAK13469.1| 1340|Homo sapiens protocadherin 11 protein. 278 2e-73
AF332216-1|AAK13468.1| 1048|Homo sapiens protocadherin 11 protein. 278 2e-73
AF277053-1|AAL55729.1| 1037|Homo sapiens protocadherin-PC protein. 278 2e-73
AB053445-1|BAB61902.1| 1147|Homo sapiens KIAA1774 protein protein. 277 6e-73
AF217288-1|AAK82656.1| 1310|Homo sapiens protocadherin-S protein. 276 1e-72
AF206516-1|AAK82655.1| 1347|Homo sapiens protocadherin-S protein. 276 1e-72
AL731541-3|CAI40838.1| 728|Homo sapiens cadherin-like 23 protein. 274 2e-72
BC051788-1|AAH51788.1| 929|Homo sapiens protocadherin gamma sub... 273 7e-72
AY563166-1|AAT72166.1| 1079|Homo sapiens cadherin 23 isoform B2 ... 273 7e-72
AY563165-1|AAT72165.1| 1114|Homo sapiens cadherin 23 isoform B1 ... 273 7e-72
AY029205-1|AAK31581.1| 1955|Homo sapiens protocadherin 15 protein. 273 7e-72
AF152523-1|AAD43783.1| 808|Homo sapiens protocadherin gamma B7 ... 273 7e-72
AF152336-1|AAD43730.1| 929|Homo sapiens protocadherin gamma B7 ... 273 7e-72
AY029237-1|AAK31804.1| 1955|Homo sapiens protocadherin 15 protein. 272 1e-71
AL365496-10|CAM19874.1| 1957|Homo sapiens protocadherin 15 protein. 272 1e-71
AL365496-9|CAH73916.1| 1955|Homo sapiens protocadherin 15 protein. 272 1e-71
AL365496-8|CAM19873.1| 1952|Homo sapiens protocadherin 15 protein. 272 1e-71
AL365496-7|CAM19872.1| 1932|Homo sapiens protocadherin 15 protein. 272 1e-71
AL365496-4|CAM19869.1| 1539|Homo sapiens protocadherin 15 protein. 272 1e-71
AL360214-13|CAM21544.1| 1932|Homo sapiens protocadherin 15 protein. 272 1e-71
AL360214-12|CAM21543.1| 1952|Homo sapiens protocadherin 15 protein. 272 1e-71
AL360214-11|CAM21542.1| 1957|Homo sapiens protocadherin 15 protein. 272 1e-71
AL360214-10|CAI15201.1| 1955|Homo sapiens protocadherin 15 protein. 272 1e-71
AL360214-5|CAM21537.1| 1539|Homo sapiens protocadherin 15 protein. 272 1e-71
AL360214-3|CAI15200.1| 961|Homo sapiens protocadherin 15 protein. 272 1e-71
AL356114-13|CAH71769.1| 1955|Homo sapiens protocadherin 15 protein. 272 1e-71
AL356114-12|CAM15125.1| 1932|Homo sapiens protocadherin 15 protein. 272 1e-71
AL356114-11|CAM15124.1| 1957|Homo sapiens protocadherin 15 protein. 272 1e-71
AL356114-10|CAM15123.1| 1952|Homo sapiens protocadherin 15 protein. 272 1e-71
AL356114-7|CAM15120.1| 1539|Homo sapiens protocadherin 15 protein. 272 1e-71
AL356114-3|CAH71768.1| 961|Homo sapiens protocadherin 15 protein. 272 1e-71
AL353784-11|CAM16792.1| 1957|Homo sapiens protocadherin 15 protein. 272 1e-71
AL353784-10|CAH72390.1| 1955|Homo sapiens protocadherin 15 protein. 272 1e-71
AL353784-9|CAM16791.1| 1952|Homo sapiens protocadherin 15 protein. 272 1e-71
AL353784-5|CAM16787.1| 1539|Homo sapiens protocadherin 15 protein. 272 1e-71
AL353784-2|CAH72389.1| 961|Homo sapiens protocadherin 15 protein. 272 1e-71
AL834258-1|CAD38933.1| 1084|Homo sapiens hypothetical protein pr... 267 4e-70
AL365496-3|CAM19868.1| 1785|Homo sapiens protocadherin 15 protein. 267 4e-70
AL365496-1|CAM19866.1| 1684|Homo sapiens protocadherin 15 protein. 267 4e-70
AL360214-6|CAM21538.1| 1785|Homo sapiens protocadherin 15 protein. 267 4e-70
AL360214-4|CAM21536.1| 1684|Homo sapiens protocadherin 15 protein. 267 4e-70
AL356114-6|CAM15119.1| 1785|Homo sapiens protocadherin 15 protein. 267 4e-70
AL356114-4|CAM15117.1| 1684|Homo sapiens protocadherin 15 protein. 267 4e-70
AL353784-7|CAM16789.1| 1785|Homo sapiens protocadherin 15 protein. 267 4e-70
AL353784-3|CAM16785.1| 1684|Homo sapiens protocadherin 15 protein. 267 4e-70
BC103927-1|AAI03928.1| 810|Homo sapiens protocadherin gamma sub... 262 1e-68
BC103926-1|AAI03927.1| 810|Homo sapiens protocadherin gamma sub... 262 1e-68
AF152517-1|AAD43777.1| 810|Homo sapiens protocadherin gamma B1 ... 262 1e-68
AF152330-1|AAD43724.1| 927|Homo sapiens protocadherin gamma B1 ... 262 1e-68
BC103928-1|AAI03929.1| 810|Homo sapiens protocadherin gamma sub... 261 2e-68
AJ564936-1|CAD92415.1| 787|Homo sapiens protocadherin protein. 259 1e-67
AJ564935-1|CAD92414.1| 762|Homo sapiens protocadherin protein. 259 1e-67
AJ564934-1|CAD92413.1| 841|Homo sapiens protocadherin protein. 259 1e-67
AJ564933-1|CAD92412.1| 831|Homo sapiens protocadherin protein. 259 1e-67
AJ564963-1|CAD92434.1| 787|Homo sapiens protocadherin protein. 256 6e-67
AJ564962-1|CAD92433.1| 762|Homo sapiens protocadherin protein. 256 6e-67
AJ564961-1|CAD92432.1| 841|Homo sapiens protocadherin protein. 256 6e-67
AJ564960-1|CAD92431.1| 831|Homo sapiens protocadherin protein. 256 6e-67
BC035812-1|AAH35812.1| 1060|Homo sapiens protocadherin 1 protein. 254 3e-66
AF152522-1|AAD43782.1| 820|Homo sapiens protocadherin gamma B6 ... 254 4e-66
AF152335-1|AAD43729.1| 930|Homo sapiens protocadherin gamma B6 ... 254 4e-66
BC112083-1|AAI12084.1| 878|Homo sapiens protocadherin gamma sub... 252 1e-65
BC112081-1|AAI12082.1| 878|Homo sapiens protocadherin gamma sub... 252 1e-65
AF152526-1|AAD43786.1| 878|Homo sapiens protocadherin gamma C5 ... 252 1e-65
AF152339-1|AAD43733.1| 944|Homo sapiens protocadherin gamma C5 ... 252 1e-65
BC113607-1|AAI13608.1| 803|Homo sapiens protocadherin gamma sub... 251 2e-65
BC112088-1|AAI12089.1| 803|Homo sapiens protocadherin gamma sub... 251 2e-65
AF152520-1|AAD43780.1| 803|Homo sapiens protocadherin gamma B4 ... 251 2e-65
AF152333-1|AAD43727.1| 923|Homo sapiens protocadherin gamma B4 ... 251 2e-65
BC093879-1|AAH93879.1| 818|Homo sapiens protocadherin gamma sub... 250 4e-65
BC093877-1|AAH93877.1| 818|Homo sapiens protocadherin gamma sub... 250 4e-65
AF152521-1|AAD43781.1| 818|Homo sapiens protocadherin gamma B5 ... 250 4e-65
AF152334-1|AAD43728.1| 923|Homo sapiens protocadherin gamma B5 ... 250 4e-65
BC101805-1|AAI01806.1| 811|Homo sapiens protocadherin gamma sub... 246 9e-64
AF152518-1|AAD43778.1| 811|Homo sapiens protocadherin gamma B2 ... 246 9e-64
AF152331-1|AAD43725.1| 931|Homo sapiens protocadherin gamma B2 ... 246 9e-64
AB006756-1|BAA25195.1| 1072|Homo sapiens PCDH7 (BH-Pcdh)b protein. 245 2e-63
AB006755-1|BAA25194.1| 1069|Homo sapiens PCDH7 (BH-Pcdh)a protein. 245 2e-63
AF169693-1|AAF89690.1| 947|Homo sapiens protocadherin 13 protein. 243 6e-63
BC003126-1|AAH03126.1| 808|Homo sapiens protocadherin alpha 2 p... 243 8e-63
AF152480-1|AAD43741.1| 824|Homo sapiens protocadherin alpha 2 s... 243 8e-63
AF152310-1|AAD43704.1| 948|Homo sapiens protocadherin alpha 2 p... 243 8e-63
AC005609-12|AAC34324.1| 824|Homo sapiens KIAA0345-like 12 protein. 243 8e-63
BC027907-1|AAH27907.1| 924|Homo sapiens protocadherin 20 protein. 242 1e-62
AL592490-1|CAH73802.2| 924|Homo sapiens protocadherin 20 protein. 242 1e-62
BC069064-1|AAH69064.1| 824|Homo sapiens PCDHA3 protein protein. 241 3e-62
AF152481-1|AAD43742.1| 824|Homo sapiens protocadherin alpha 3 s... 240 4e-62
AF152311-1|AAD43705.1| 950|Homo sapiens protocadherin alpha 3 p... 240 4e-62
AC005609-11|AAC34323.1| 824|Homo sapiens KIAA0345-like 11 protein. 240 4e-62
BC129807-1|AAI29808.1| 824|Homo sapiens protocadherin alpha 3 p... 239 1e-61
AF152513-1|AAD43773.1| 818|Homo sapiens protocadherin gamma A6 ... 239 1e-61
AF152326-1|AAD43720.1| 932|Homo sapiens protocadherin gamma A6 ... 239 1e-61
AB209178-1|BAD92415.1| 950|Homo sapiens protocadherin gamma sub... 237 5e-61
BC113460-1|AAI13461.1| 813|Homo sapiens protocadherin gamma sub... 235 1e-60
BC104926-1|AAI04927.1| 813|Homo sapiens protocadherin gamma sub... 235 1e-60
AF152512-1|AAD43772.1| 813|Homo sapiens protocadherin gamma A5 ... 235 1e-60
AF152478-1|AAD43739.1| 807|Homo sapiens protocadherin alpha 13 ... 235 1e-60
AF152325-1|AAD43719.1| 931|Homo sapiens protocadherin gamma A5 ... 235 1e-60
AF152309-1|AAD43703.1| 950|Homo sapiens protocadherin alpha 13 ... 235 1e-60
AC005609-1|AAC34314.1| 807|Homo sapiens KIAA0345-like 1 protein. 235 1e-60
AB208924-1|BAD92161.1| 921|Homo sapiens protocadherin alpha 13 ... 235 1e-60
BC113609-1|AAI13610.1| 798|Homo sapiens protocadherin alpha 4 p... 235 2e-60
BC112102-1|AAI12103.1| 798|Homo sapiens protocadherin alpha 4, ... 235 2e-60
AF152482-1|AAD43743.1| 798|Homo sapiens protocadherin alpha 4 s... 235 2e-60
AF152312-1|AAD43706.1| 947|Homo sapiens protocadherin alpha 4 p... 235 2e-60
AC005609-10|AAC34322.1| 798|Homo sapiens KIAA0345-like 10 protein. 235 2e-60
AB208925-1|BAD92162.1| 921|Homo sapiens protocadherin alpha 4 i... 235 2e-60
BC036674-1|AAH36674.1| 950|Homo sapiens PCDHA6 protein protein. 233 9e-60
AF152484-1|AAD43745.1| 803|Homo sapiens protocadherin alpha 6 s... 233 9e-60
AF152314-1|AAD43708.1| 950|Homo sapiens protocadherin alpha 6 p... 233 9e-60
AC005609-8|AAC34320.1| 803|Homo sapiens KIAA0345-like 8 protein. 233 9e-60
AF152486-1|AAD43747.1| 814|Homo sapiens protocadherin alpha 8 s... 231 2e-59
AF152316-1|AAD43710.1| 950|Homo sapiens protocadherin alpha 8 p... 231 2e-59
AC005609-6|AAC34318.1| 814|Homo sapiens KIAA0345-like 6 protein. 231 2e-59
BC105111-1|AAI05112.1| 884|Homo sapiens protocadherin alpha sub... 228 2e-58
BC104776-1|AAI04777.1| 884|Homo sapiens protocadherin alpha sub... 228 2e-58
BC063288-1|AAH63288.1| 1007|Homo sapiens protocadherin alpha sub... 228 2e-58
AY358946-1|AAQ89305.1| 916|Homo sapiens cadherin FIB3 protein. 228 2e-58
AJ007609-1|CAC22256.1| 949|Homo sapiens protocadherin alpha 11 ... 228 2e-58
AF152506-1|AAD43767.1| 820|Homo sapiens protocadherin gamma A12... 228 2e-58
AF152483-1|AAD43744.1| 816|Homo sapiens protocadherin alpha 5 s... 228 2e-58
AF152476-1|AAD43737.1| 810|Homo sapiens protocadherin alpha 11 ... 228 2e-58
AF152474-1|AAD43735.1| 884|Homo sapiens protocadherin alpha C2 ... 228 2e-58
AF152321-1|AAD43715.1| 932|Homo sapiens protocadherin gamma A12... 228 2e-58
AF152313-1|AAD43707.1| 936|Homo sapiens protocadherin alpha 5 p... 228 2e-58
AF152307-1|AAD43701.1| 949|Homo sapiens protocadherin alpha 11 ... 228 2e-58
AF152304-1|AAD43698.1| 1007|Homo sapiens protocadherin alpha C2 ... 228 2e-58
AC005609-9|AAC34321.1| 816|Homo sapiens KIAA0345-like 9 protein. 228 2e-58
AC005609-3|AAC34316.1| 810|Homo sapiens KIAA0345-like 3 protein. 228 2e-58
AB011160-1|BAA25514.2| 938|Homo sapiens KIAA0588 protein protein. 228 2e-58
AF152519-1|AAD43779.1| 814|Homo sapiens protocadherin gamma B3 ... 227 3e-58
AF152332-1|AAD43726.1| 929|Homo sapiens protocadherin gamma B3 ... 227 3e-58
BC033735-1|AAH33735.1| 890|Homo sapiens PCDHA5 protein protein. 226 8e-58
AF217748-1|AAK51616.1| 800|Homo sapiens protocadherin-beta10 pr... 225 2e-57
AF152514-1|AAD43774.1| 817|Homo sapiens protocadherin gamma A7 ... 225 2e-57
AF152479-1|AAD43740.1| 807|Homo sapiens protocadherin alpha 1 s... 225 2e-57
AF152327-1|AAD43721.1| 932|Homo sapiens protocadherin gamma A7 ... 225 2e-57
AF152305-1|AAD43699.1| 950|Homo sapiens protocadherin alpha 1 p... 225 2e-57
AC005609-13|AAC34325.1| 807|Homo sapiens KIAA0345-like 13 protein. 225 2e-57
BC112098-1|AAI12099.1| 818|Homo sapiens protocadherin beta 1, p... 225 2e-57
BC112096-1|AAI12097.1| 818|Homo sapiens protocadherin beta 1, p... 225 2e-57
AF152488-1|AAD43749.1| 818|Homo sapiens protocadherin beta 1 pr... 225 2e-57
AB208958-1|BAD92195.1| 895|Homo sapiens protocadherin gamma sub... 224 3e-57
BC031837-1|AAH31837.1| 800|Homo sapiens protocadherin beta 10 p... 224 4e-57
AY358720-1|AAQ89082.1| 800|Homo sapiens PCDHB10 protein. 224 4e-57
AF152489-1|AAD43750.1| 800|Homo sapiens protocadherin beta 10 p... 224 4e-57
BC101038-1|AAI01039.1| 871|Homo sapiens protocadherin gamma sub... 223 5e-57
BC101036-1|AAI01037.1| 870|Homo sapiens PCDHGC4 protein protein. 223 5e-57
BC101035-1|AAI01036.1| 871|Homo sapiens protocadherin gamma sub... 223 5e-57
AF152525-1|AAD43785.1| 871|Homo sapiens protocadherin gamma C4 ... 223 5e-57
AF152485-1|AAD43746.1| 789|Homo sapiens protocadherin alpha 7 s... 223 5e-57
AF152338-1|AAD43732.1| 938|Homo sapiens protocadherin gamma C4 ... 223 5e-57
AF152315-1|AAD43709.1| 937|Homo sapiens protocadherin alpha 7 p... 223 5e-57
AC005609-7|AAC34319.1| 789|Homo sapiens KIAA0345-like 7 protein. 223 5e-57
AF217749-1|AAF81913.1| 797|Homo sapiens protocadherin beta 9 pr... 223 7e-57
BC104804-1|AAI04805.1| 950|Homo sapiens protocadherin alpha 9 p... 223 1e-56
BC104802-1|AAI04803.1| 950|Homo sapiens protocadherin alpha 9 p... 223 1e-56
AJ007610-1|CAC22257.1| 950|Homo sapiens protocadherin alpha 9 p... 223 1e-56
AF152487-1|AAD43748.1| 842|Homo sapiens protocadherin alpha 9 s... 223 1e-56
AF152317-1|AAD43711.1| 950|Homo sapiens protocadherin alpha 9 p... 223 1e-56
AC005609-5|AAC34313.1| 842|Homo sapiens KIAA0345-like 5 protein. 223 1e-56
AB002343-1|BAA20803.2| 845|Homo sapiens KIAA0345 protein. 223 1e-56
BC105640-1|AAI05641.1| 797|Homo sapiens protocadherin beta 9 pr... 222 1e-56
BC103494-1|AAI03495.1| 796|Homo sapiens PCDHB9 protein protein. 222 1e-56
BC071934-1|AAH71934.1| 798|Homo sapiens protocadherin beta 13 p... 222 1e-56
BC051348-1|AAH51348.1| 798|Homo sapiens protocadherin beta 13 p... 222 1e-56
BC033068-1|AAH33068.1| 798|Homo sapiens protocadherin beta 13 p... 222 1e-56
AY358427-1|AAQ88793.1| 798|Homo sapiens PCDHB13 protein. 222 1e-56
AF217745-1|AAK51613.1| 798|Homo sapiens protocadherin-beta13 pr... 222 1e-56
AF152505-1|AAD43766.1| 837|Homo sapiens protocadherin gamma A11... 222 1e-56
AF152502-1|AAD43763.2| 797|Homo sapiens protocadherin beta 9 pr... 222 1e-56
AF152492-1|AAD43753.1| 798|Homo sapiens protocadherin beta 13 p... 222 1e-56
AF152320-1|AAD43714.1| 935|Homo sapiens protocadherin gamma A11... 222 1e-56
AF152511-1|AAD43771.1| 820|Homo sapiens protocadherin gamma A4 ... 221 2e-56
AF152324-1|AAD43718.1| 931|Homo sapiens protocadherin gamma A4 ... 221 2e-56
BC105636-1|AAI05637.1| 797|Homo sapiens protocadherin beta 9 pr... 221 4e-56
BC100672-1|AAI00673.1| 797|Homo sapiens protocadherin beta 9 pr... 221 4e-56
AF217742-1|AAK51610.1| 787|Homo sapiens protocadherin-beta15 pr... 221 4e-56
AF152494-1|AAD43755.1| 787|Homo sapiens protocadherin beta 15 p... 221 4e-56
BC113372-1|AAI13373.1| 792|Homo sapiens protocadherin alpha 12 ... 220 7e-56
BC112280-1|AAI12281.1| 792|Homo sapiens protocadherin alpha 12,... 220 7e-56
AF152477-1|AAD43738.1| 792|Homo sapiens protocadherin alpha 12 ... 220 7e-56
AF152308-1|AAD43702.1| 941|Homo sapiens protocadherin alpha 12 ... 220 7e-56
AC005609-2|AAC34315.1| 792|Homo sapiens KIAA0345-like 2 protein. 220 7e-56
AB160984-1|BAD08246.1| 1123|Homo sapiens KIAA0811 protein protein. 219 9e-56
BC112084-1|AAI12085.1| 823|Homo sapiens protocadherin gamma sub... 219 1e-55
BC112082-1|AAI12083.1| 823|Homo sapiens protocadherin gamma sub... 219 1e-55
BC028165-1|AAH28165.1| 1159|Homo sapiens protocadherin 17 protein. 219 1e-55
AL445288-1|CAI17092.1| 1159|Homo sapiens protocadherin 17 protein. 219 1e-55
AL445216-1|CAH71250.1| 1159|Homo sapiens protocadherin 17 protein. 219 1e-55
BC093815-1|AAH93815.1| 1135|Homo sapiens protocadherin 18 protein. 219 2e-55
BC038797-1|AAH38797.1| 787|Homo sapiens protocadherin beta 15 p... 219 2e-55
AF152507-1|AAD43768.1| 823|Homo sapiens protocadherin gamma A1 ... 219 2e-55
AF152318-1|AAD43712.1| 931|Homo sapiens protocadherin gamma A1 ... 219 2e-55
AB046782-1|BAB13388.1| 1136|Homo sapiens KIAA1562 protein protein. 219 2e-55
AF029343-1|AAB84144.1| 889|Homo sapiens protocadherin 68 protein. 217 4e-55
AK222560-1|BAD96280.1| 793|Homo sapiens protocadherin beta 7 pr... 217 6e-55
AK000054-1|BAA90911.1| 959|Homo sapiens protein ( Homo sapiens ... 217 6e-55
AB208959-1|BAD92196.1| 716|Homo sapiens protocadherin beta 9 pr... 217 6e-55
BC104950-1|AAI04951.1| 823|Homo sapiens protocadherin gamma sub... 216 8e-55
BC093871-1|AAH93871.1| 823|Homo sapiens protocadherin gamma sub... 216 8e-55
AF152508-1|AAD43769.1| 823|Homo sapiens protocadherin gamma A2 ... 216 8e-55
AF152322-1|AAD43716.1| 932|Homo sapiens protocadherin gamma A2 ... 216 8e-55
BC098574-1|AAH98574.1| 793|Homo sapiens protocadherin beta 7 pr... 215 2e-54
BC130333-1|AAI30334.1| 793|Homo sapiens protocadherin beta 7 pr... 215 3e-54
AK222678-1|BAD96398.1| 793|Homo sapiens protocadherin beta 7 pr... 215 3e-54
AF152503-1|AAD43764.1| 850|Homo sapiens protocadherin gamma A10... 215 3e-54
AF152319-1|AAD43713.1| 936|Homo sapiens protocadherin gamma A10... 215 3e-54
AB006757-1|BAA25196.1| 1200|Homo sapiens PCDH7 (BH-Pcdh)c protein. 215 3e-54
BC130331-1|AAI30332.1| 793|Homo sapiens protocadherin beta 7 pr... 214 3e-54
BC093875-1|AAH93875.1| 850|Homo sapiens protocadherin gamma sub... 214 3e-54
BC093873-1|AAH93873.1| 850|Homo sapiens protocadherin gamma sub... 214 3e-54
AF217750-1|AAK51617.1| 793|Homo sapiens protocadherin-beta7 pro... 214 3e-54
AF152500-1|AAD43761.1| 793|Homo sapiens protocadherin beta 7 pr... 214 3e-54
AC079298-1|AAY41019.1| 959|Homo sapiens unknown protein. 214 3e-54
BC132769-1|AAI32770.1| 828|Homo sapiens protocadherin gamma sub... 213 8e-54
AF152516-1|AAD43776.1| 828|Homo sapiens protocadherin gamma A9 ... 213 8e-54
AF152329-1|AAD43723.1| 932|Homo sapiens protocadherin gamma A9 ... 213 8e-54
BC045637-1|AAH45637.1| 795|Homo sapiens protocadherin beta 12 p... 213 1e-53
AF217746-1|AAK51614.1| 795|Homo sapiens protocadherin-beta12 pr... 213 1e-53
AF152491-1|AAD43752.1| 795|Homo sapiens protocadherin beta 12 p... 213 1e-53
AF152473-1|AAD43734.1| 818|Homo sapiens protocadherin alpha C1 ... 212 1e-53
AF152303-1|AAD43697.1| 963|Homo sapiens protocadherin alpha C1 ... 212 1e-53
AK074160-1|BAB84986.1| 535|Homo sapiens FLJ00233 protein protein. 211 2e-53
AB046841-1|BAB13447.1| 787|Homo sapiens KIAA1621 protein protein. 211 2e-53
BC130282-1|AAI30283.1| 1310|Homo sapiens PCLKC protein protein. 210 4e-53
AB047004-1|BAB40777.1| 1310|Homo sapiens protocadherin LKC protein. 210 4e-53
AJ007608-1|CAC22255.1| 963|Homo sapiens protocadherin alpha-C1 ... 210 5e-53
BC036062-1|AAH36062.1| 776|Homo sapiens protocadherin beta 16 p... 210 7e-53
AF152475-1|AAD43736.1| 844|Homo sapiens protocadherin alpha 10 ... 210 7e-53
AF152306-1|AAD43700.1| 948|Homo sapiens protocadherin alpha 10 ... 210 7e-53
AC005609-4|AAC34317.1| 844|Homo sapiens KIAA0345-like 4 protein. 210 7e-53
BC113611-1|AAI13612.1| 797|Homo sapiens protocadherin beta 11 p... 208 2e-52
BC112132-1|AAI12133.1| 797|Homo sapiens protocadherin beta 11 p... 208 2e-52
AF217747-1|AAK51615.1| 797|Homo sapiens protocadherin-beta11 pr... 208 2e-52
AF152490-1|AAD43751.1| 797|Homo sapiens protocadherin beta 11 p... 208 2e-52
AB209225-1|BAD92462.1| 799|Homo sapiens protocadherin beta 11 p... 208 2e-52
AY013878-1|AAK21988.1| 776|Homo sapiens protocadherin beta 8a p... 208 3e-52
AF282973-2|AAG10030.1| 776|Homo sapiens protocadherin-3x protein. 207 5e-52
AF217757-1|AAF81914.1| 776|Homo sapiens protocadherin 3X protein. 207 5e-52
AL834254-1|CAD38929.1| 647|Homo sapiens hypothetical protein pr... 206 7e-52
AF152501-1|AAD43762.2| 801|Homo sapiens protocadherin beta 8 pr... 204 3e-51
AF152323-1|AAD43717.1| 932|Homo sapiens protocadherin gamma A3 ... 204 3e-51
BC099728-1|AAH99728.1| 798|Homo sapiens protocadherin beta 14 p... 204 4e-51
BC098144-1|AAH98144.1| 797|Homo sapiens PCDHB14 protein protein. 204 4e-51
AF217744-1|AAK51612.1| 798|Homo sapiens protocadherin-beta14 pr... 204 4e-51
AF152493-1|AAD43754.1| 798|Homo sapiens protocadherin beta 14 p... 204 4e-51
AF217752-1|AAK51619.1| 794|Homo sapiens protocadherin-beta6 pro... 203 6e-51
AF152499-1|AAD43760.1| 794|Homo sapiens protocadherin beta 6 pr... 203 6e-51
BC133708-1|AAI33709.1| 693|Homo sapiens PCDHGA3 protein protein. 202 1e-50
AB208927-1|BAD92164.1| 961|Homo sapiens protocadherin gamma sub... 202 1e-50
L11373-1|AAA75391.1| 904|Homo sapiens protocadherin 43 protein. 202 1e-50
BC115409-1|AAI15410.1| 694|Homo sapiens PCDHGA3 protein protein. 202 2e-50
BC115408-1|AAI15409.1| 694|Homo sapiens PCDHGA3 protein protein. 202 2e-50
AY013874-1|AAK21987.1| 896|Homo sapiens protocadherin 10 protein. 202 2e-50
AF152510-1|AAD43770.1| 829|Homo sapiens protocadherin gamma A3 ... 202 2e-50
AC105383-1|AAY41018.1| 1040|Homo sapiens unknown protein. 202 2e-50
AB037821-1|BAA92638.1| 1093|Homo sapiens KIAA1400 protein protein. 202 2e-50
BC001186-1|AAH01186.1| 795|Homo sapiens protocadherin beta 5 pr... 201 3e-50
AF217753-1|AAK51620.1| 795|Homo sapiens protocadherin-beta5 pro... 201 3e-50
AF152498-1|AAD43759.1| 795|Homo sapiens protocadherin beta 5 pr... 201 3e-50
AF134474-1|AAP97251.1| 795|Homo sapiens protocadherin protein. 201 3e-50
AB209393-1|BAD92630.1| 796|Homo sapiens protocadherin beta 5 pr... 201 3e-50
BC101049-1|AAI01050.1| 801|Homo sapiens cadherin 20, type 2 pro... 201 3e-50
BC101048-1|AAI01049.1| 801|Homo sapiens cadherin 20, type 2 pro... 201 3e-50
BC101047-1|AAI01048.1| 801|Homo sapiens cadherin 20, type 2 pro... 201 3e-50
AF217289-1|AAG23739.1| 801|Homo sapiens cadherin 20 protein. 201 3e-50
AF152515-1|AAD43775.1| 820|Homo sapiens protocadherin gamma A8 ... 201 3e-50
AF152328-1|AAD43722.1| 932|Homo sapiens protocadherin gamma A8 ... 201 3e-50
AB002325-1|BAA20785.2| 898|Homo sapiens KIAA0327 protein protein. 201 3e-50
AF217743-1|AAK51611.1| 734|Homo sapiens protocadherin-psi2 prot... 200 4e-50
AF152504-1|AAD43765.1| 750|Homo sapiens protocadherin gamma A11... 200 4e-50
BC111560-1|AAI11561.1| 1040|Homo sapiens protocadherin 10 protein. 200 6e-50
BC098575-1|AAH98575.1| 798|Homo sapiens protocadherin beta 2 pr... 199 1e-49
BC098347-1|AAH98347.1| 798|Homo sapiens protocadherin beta 2, p... 199 1e-49
AF217756-1|AAK51623.1| 798|Homo sapiens protocadherin-beta2 pro... 199 1e-49
AF152495-1|AAD43756.1| 798|Homo sapiens protocadherin beta 2 pr... 199 1e-49
AB209745-1|BAD92982.1| 784|Homo sapiens protocadherin beta 2 pr... 199 1e-49
BC026218-1|AAH26218.1| 934|Homo sapiens protocadherin gamma sub... 196 7e-49
BC019299-1|AAH19299.1| 934|Homo sapiens protocadherin gamma sub... 196 7e-49
AF152524-1|AAD43784.1| 863|Homo sapiens protocadherin gamma C3 ... 196 7e-49
AF152337-1|AAD43731.1| 934|Homo sapiens protocadherin gamma C3 ... 196 7e-49
AF052685-1|AAC08350.1| 934|Homo sapiens protocadherin 43 protein. 196 7e-49
AL031687-1|CAB51587.2| 828|Homo sapiens cadherin-like 22 protein. 196 1e-48
D31784-1|BAA06562.1| 790|Homo sapiens cadherin-6 protein. 195 2e-48
BC104817-1|AAI04818.1| 796|Homo sapiens protocadherin beta 3 pr... 195 2e-48
BC000019-1|AAH00019.1| 663|Homo sapiens CDH6 protein protein. 195 2e-48
AF282973-1|AAG10031.1| 610|Homo sapiens protocadherin-beta8 pro... 195 2e-48
AF217755-1|AAK51622.1| 796|Homo sapiens protocadherin-beta3 pro... 195 2e-48
AF152496-1|AAD43757.1| 796|Homo sapiens protocadherin beta 3 pr... 195 2e-48
BC036786-1|AAH36786.1| 630|Homo sapiens CDH7 protein protein. 192 2e-47
AJ007611-1|CAC13127.1| 784|Homo sapiens cadherin-7 protein. 192 2e-47
AB035301-1|BAA87415.1| 785|Homo sapiens cadherin-7 protein. 192 2e-47
L33477-1|AAB48539.1| 794|Homo sapiens Br-cadherin protein. 190 6e-47
BC052973-1|AAH52973.1| 1187|Homo sapiens PCDH12 protein protein. 190 6e-47
BC047608-1|AAH47608.1| 794|Homo sapiens cadherin 12, type 2 (N-... 190 6e-47
BC042634-1|AAH42634.1| 1187|Homo sapiens PCDH12 protein protein. 190 6e-47
AY358428-1|AAQ88794.1| 1184|Homo sapiens PCDH12 protein. 190 6e-47
AK024140-1|BAB14837.1| 1187|Homo sapiens protein ( Homo sapiens ... 190 6e-47
AF240635-1|AAF73962.1| 1184|Homo sapiens vascular endothelial ca... 190 6e-47
AF231025-1|AAF61931.1| 1184|Homo sapiens protocadherin 12 protein. 190 6e-47
AB026893-1|BAA95162.1| 1184|Homo sapiens vascular cadherin-2 pro... 190 6e-47
L34057-1|AAA35623.1| 794|Homo sapiens cadherin-12 protein. 190 8e-47
BC113416-1|AAI13417.1| 799|Homo sapiens cadherin 8, type 2 prot... 189 1e-46
AB035305-1|BAA87419.1| 799|Homo sapiens cadherin-8 protein. 189 1e-46
AF169695-1|AAF89692.1| 686|Homo sapiens protocadherin alpha 1 a... 189 1e-46
BC113745-1|AAI13746.1| 789|Homo sapiens cadherin 9, type 2, pre... 187 4e-46
BC107594-1|AAI07595.1| 789|Homo sapiens cadherin 9, type 2 (T1-... 187 4e-46
AB035302-1|BAA87416.1| 789|Homo sapiens cadherin-9 protein. 187 4e-46
BC038799-1|AAH38799.1| 745|Homo sapiens PCDH21 protein protein. 187 6e-46
AB053448-1|BAB61905.1| 858|Homo sapiens KIAA1775 protein protein. 187 6e-46
L34060-1|AAA35628.1| 793|Homo sapiens cadherin-8 protein. 186 8e-46
AK093818-1|BAC04231.1| 455|Homo sapiens protein ( Homo sapiens ... 184 4e-45
AF169694-1|AAF89691.1| 695|Homo sapiens protocadherin alpha 6 a... 184 5e-45
AL360214-1|CAM21534.1| 718|Homo sapiens protocadherin 15 protein. 183 7e-45
AL356114-1|CAM15115.1| 718|Homo sapiens protocadherin 15 protein. 183 7e-45
U59325-1|AAB02933.1| 790|Homo sapiens cadherin-14 protein. 183 9e-45
BC098346-1|AAH98346.1| 795|Homo sapiens protocadherin beta 4 pr... 183 9e-45
BC098139-1|AAH98139.1| 795|Homo sapiens protocadherin beta 4 pr... 183 9e-45
BC031051-1|AAH31051.1| 790|Homo sapiens cadherin 18, type 2 pro... 183 9e-45
AF217754-1|AAK51621.1| 795|Homo sapiens protocadherin-beta4 pro... 183 9e-45
AF152497-1|AAD43758.1| 795|Homo sapiens protocadherin beta 4 pr... 183 9e-45
AK021915-1|BAB13935.1| 744|Homo sapiens protein ( Homo sapiens ... 182 2e-44
AB035303-1|BAA87417.1| 788|Homo sapiens cadherin-10 protein. 180 5e-44
L34056-1|AAA35622.1| 796|Homo sapiens cadherin-11 protein. 180 7e-44
D21255-1|BAA04799.1| 693|Homo sapiens OB-cadherin-2 protein. 179 2e-43
D21254-1|BAA04798.1| 796|Homo sapiens OB-cadherin-1 protein. 179 2e-43
AF039747-1|AAD44017.1| 788|Homo sapiens cadherin-10 protein. 179 2e-43
AB209760-1|BAD92997.1| 798|Homo sapiens cadherin 11, type 2 iso... 178 3e-43
BC013609-1|AAH13609.1| 796|Homo sapiens cadherin 11, type 2, OB... 177 4e-43
BC130447-1|AAI30448.1| 685|Homo sapiens protocadherin alpha 10 ... 177 5e-43
AF217751-1|AAK51618.1| 587|Homo sapiens protocadherin-psi1 prot... 176 8e-43
AF169689-1|AAF89329.1| 685|Homo sapiens protocadherin alpha 10 ... 176 8e-43
AY354498-1|AAR10444.1| 702|Homo sapiens protocadherin protein p... 172 2e-41
AY358654-1|AAQ89017.1| 772|Homo sapiens CDH19 protein. 171 2e-41
AJ007607-1|CAC13126.1| 772|Homo sapiens cadherin-19 protein. 171 2e-41
BC011570-1|AAH11570.1| 530|Homo sapiens cadherin-like 23 protein. 170 7e-41
AY358617-1|AAQ88980.1| 530|Homo sapiens CDH23 protein. 170 7e-41
AL122081-1|CAB59256.1| 373|Homo sapiens hypothetical protein pr... 168 2e-40
BC036470-1|AAH36470.1| 906|Homo sapiens cadherin 2, type 1, N-c... 165 2e-39
AF169691-1|AAF89688.1| 398|Homo sapiens cadherin-like protein V... 165 2e-39
X79981-1|CAA56306.1| 784|Homo sapiens VE-cadherin protein. 163 8e-39
S42303-1|AAB22854.1| 905|Homo sapiens N-cadherin protein. 163 8e-39
AL365496-6|CAM19871.1| 981|Homo sapiens protocadherin 15 protein. 163 8e-39
AL360214-7|CAM21539.1| 981|Homo sapiens protocadherin 15 protein. 163 8e-39
AL356114-8|CAM15121.1| 981|Homo sapiens protocadherin 15 protein. 163 8e-39
AL353784-6|CAM16788.1| 981|Homo sapiens protocadherin 15 protein. 163 8e-39
AB035304-1|BAA87418.1| 784|Homo sapiens cadherin-5 protein. 163 8e-39
AF282973-3|AAG10032.1| 536|Homo sapiens protocadherin-beta9 pro... 163 1e-38
X59796-1|CAA42468.1| 780|Homo sapiens cadherin-5 protein. 162 1e-38
U84722-1|AAB41796.1| 784|Homo sapiens vascular endothelial cadh... 162 1e-38
M34064-1|AAA03236.1| 747|Homo sapiens NCAD protein. 162 1e-38
BC042650-1|AAH42650.1| 605|Homo sapiens PCDHGC3 protein protein. 162 1e-38
AB209908-1|BAD93145.1| 807|Homo sapiens cadherin 5, type 2 prep... 162 1e-38
X54315-1|CAA38213.1| 906|Homo sapiens protein ( Human mRNA for ... 161 2e-38
BC113464-1|AAI13465.1| 832|Homo sapiens cadherin 17, LI cadheri... 161 2e-38
BC112013-1|AAI12014.1| 832|Homo sapiens cadherin 17, precursor ... 161 2e-38
U07969-1|AAA19021.1| 832|Homo sapiens intestinal peptide-associ... 161 4e-38
X83228-1|CAA58231.1| 832|Homo sapiens LI-cadherin protein. 160 6e-38
BC112150-1|AAI12151.1| 916|Homo sapiens cadherin 4, type 1, pre... 160 6e-38
BC101651-1|AAI01652.1| 916|Homo sapiens cadherin 4, type 1, R-c... 160 6e-38
AL365401-1|CAC26840.2| 916|Homo sapiens cadherin 4, type 1, R-c... 160 6e-38
AL365229-1|CAI16510.1| 916|Homo sapiens cadherin 4, type 1, R-c... 160 6e-38
AL162457-1|CAH73749.1| 916|Homo sapiens cadherin 4, type 1, R-c... 160 6e-38
AL109911-1|CAI19181.1| 916|Homo sapiens cadherin 4, type 1, R-c... 160 6e-38
AK091496-1|BAC03677.1| 824|Homo sapiens protein ( Homo sapiens ... 160 8e-38
AY358199-1|AAQ88566.1| 781|Homo sapiens CDH24 protein. 156 9e-37
AY260900-1|AAP20590.1| 781|Homo sapiens cadherin-24 protein. 156 9e-37
BC117520-1|AAI17521.1| 669|Homo sapiens CDH5 protein protein. 155 2e-36
BC096364-1|AAH96364.3| 669|Homo sapiens CDH5 protein protein. 155 2e-36
BC096363-1|AAH96363.1| 669|Homo sapiens CDH5 protein protein. 155 2e-36
Z35402-1|CAA84586.1| 827|Homo sapiens E-cadherin protein. 154 5e-36
Z13009-1|CAA78353.1| 882|Homo sapiens E-cadherin protein. 154 5e-36
L34059-1|AAA35627.1| 916|Homo sapiens cadherin-4 protein. 154 5e-36
DQ090940-1|AAY68225.1| 882|Homo sapiens cadherin 1, type 1, E-c... 154 5e-36
BC141838-1|AAI41839.1| 647|Homo sapiens Unknown (protein for MG... 154 5e-36
U59289-1|AAB18912.1| 713|Homo sapiens H-cadherin protein. 153 7e-36
U59288-1|AAB18911.1| 713|Homo sapiens H-cadherin protein. 153 7e-36
L34058-1|AAA35624.1| 713|Homo sapiens cadherin-13 protein. 153 7e-36
AK057922-1|BAB71613.1| 493|Homo sapiens protein ( Homo sapiens ... 153 7e-36
AB001103-1|BAA32411.1| 713|Homo sapiens H-cadherin protein. 153 7e-36
BC015877-1|AAH15877.1| 390|Homo sapiens CDH19 protein protein. 153 9e-36
Z18923-1|CAA79356.1| 882|Homo sapiens E-cadherin protein. 153 1e-35
BC096365-1|AAH96365.1| 662|Homo sapiens CDH5 protein protein. 153 1e-35
BC030653-1|AAH30653.1| 713|Homo sapiens cadherin 13, H-cadherin... 153 1e-35
BC028624-1|AAH28624.1| 713|Homo sapiens cadherin 13, H-cadherin... 153 1e-35
BC139903-1|AAI39904.1| 406|Homo sapiens Unknown (protein for MG... 152 2e-35
L08599-1|AAA61259.1| 878|Homo sapiens uvomorulin protein. 151 3e-35
X57548-1|CAA40773.1| 748|Homo sapiens N-cadherin protein. 149 2e-34
X63629-1|CAA45177.1| 829|Homo sapiens p-cadherin protein. 148 3e-34
BC014462-1|AAH14462.1| 784|Homo sapiens CDH3 protein protein. 148 3e-34
BC041846-1|AAH41846.1| 829|Homo sapiens cadherin 3, type 1, P-c... 146 8e-34
BC027912-1|AAH27912.1| 829|Homo sapiens cadherin 16, KSP-cadher... 142 2e-32
AY358911-1|AAQ89270.1| 807|Homo sapiens Ksp-cadherin protein. 142 2e-32
AF016272-1|AAC34255.1| 829|Homo sapiens Ksp-cadherin protein. 142 2e-32
AY260901-1|AAP20591.1| 819|Homo sapiens cadherin-24 variant pro... 138 2e-31
AB074170-1|BAE45735.1| 348|Homo sapiens putative protein produc... 133 8e-30
BC109240-1|AAI09241.1| 269|Homo sapiens IL19 protein protein. 133 1e-29
AB209205-1|BAD92442.1| 430|Homo sapiens protocadherin alpha 6 i... 131 3e-29
BC108254-1|AAI08255.1| 445|Homo sapiens CDH23 protein protein. 130 9e-29
BC036025-1|AAH36025.1| 1070|Homo sapiens protocadherin 8 protein. 128 4e-28
AY013873-1|AAK21986.1| 973|Homo sapiens protocadherin ARCADLIN ... 128 4e-28
AL139085-5|CAI14111.1| 973|Homo sapiens protocadherin 8 protein. 128 4e-28
AL139085-4|CAI14110.1| 1070|Homo sapiens protocadherin 8 protein. 128 4e-28
AF061573-1|AAC70009.2| 1070|Homo sapiens protocadherin protein. 128 4e-28
D83542-1|BAA12012.1| 814|Homo sapiens cadherin-15 protein. 126 1e-27
BC008951-1|AAH08951.1| 814|Homo sapiens cadherin 15, M-cadherin... 126 1e-27
AF131761-1|AAD20038.1| 420|Homo sapiens Similar to protocadheri... 124 5e-27
AF135156-1|AAG43278.1| 260|Homo sapiens D-cadherin precursor pr... 122 2e-26
BC016722-1|AAH16722.1| 230|Homo sapiens FAT3 protein protein. 120 1e-25
AB025106-1|BAA88957.1| 901|Homo sapiens E-cadherin protein. 118 3e-25
AK027282-1|BAB55016.1| 390|Homo sapiens protein ( Homo sapiens ... 117 7e-25
X56654-1|CAA39976.1| 1049|Homo sapiens desmoglein type 1 protein. 114 4e-24
AF097935-1|AAC83817.1| 1049|Homo sapiens desmoglein 1 protein. 114 4e-24
AL137471-1|CAB70755.1| 709|Homo sapiens hypothetical protein pr... 113 7e-24
AL109928-5|CAD55557.2| 832|Homo sapiens cadherin-like 26 protein. 113 9e-24
X56807-2|CAA40142.1| 914|Homo sapiens desmocollin type 2b protein. 113 1e-23
X56807-1|CAA40141.1| 860|Homo sapiens desmocollin type 2a protein. 113 1e-23
BC132909-1|AAI32910.1| 1040|Homo sapiens desmoglein 4 protein. 113 1e-23
BC132907-1|AAI32908.1| 1040|Homo sapiens desmoglein 4 protein. 113 1e-23
BC063291-1|AAH63291.1| 901|Homo sapiens desmocollin 2 protein. 113 1e-23
AY228236-1|AAP49811.1| 1059|Homo sapiens desmoglein 4 protein. 113 1e-23
AY227350-1|AAP45000.1| 1040|Homo sapiens desmoglein 4 protein. 113 1e-23
AY177664-1|AAO47078.1| 1040|Homo sapiens desmoglein 4 preproprot... 113 1e-23
AY177663-1|AAO47077.1| 1040|Homo sapiens desmoglein 4 preproprot... 113 1e-23
AY168788-1|AAO43657.1| 1059|Homo sapiens desmoglein 4 protein. 113 1e-23
Z26317-1|CAA81226.1| 1117|Homo sapiens desmoglein 2 protein. 112 2e-23
BC099657-1|AAH99657.1| 1118|Homo sapiens desmoglein 2 protein. 112 2e-23
BC099656-1|AAH99656.1| 1118|Homo sapiens desmoglein 2 protein. 112 2e-23
BC099655-1|AAH99655.1| 1118|Homo sapiens desmoglein 2 protein. 112 2e-23
BC051287-1|AAH51287.1| 345|Homo sapiens PCDH1 protein protein. 109 2e-22
X83929-1|CAA58781.1| 896|Homo sapiens desmocollin type 3 protein. 104 4e-21
D17427-1|BAA04249.1| 896|Homo sapiens desmocollin type 4 protein. 104 4e-21
AF293359-2|AAG23427.1| 839|Homo sapiens desmocollin 3b protein. 104 4e-21
AF293359-1|AAG23426.1| 896|Homo sapiens desmocollin 3a protein. 104 4e-21
AK023785-1|BAB14677.1| 808|Homo sapiens protein ( Homo sapiens ... 101 4e-20
AB025105-1|BAA88956.1| 821|Homo sapiens E-cadherin protein. 101 4e-20
BC111738-1|AAI11739.1| 885|Homo sapiens hypothetical protein LO... 99 1e-19
BC111696-1|AAI11697.1| 885|Homo sapiens hypothetical protein LO... 99 1e-19
AK126338-1|BAC86529.1| 885|Homo sapiens protein ( Homo sapiens ... 99 1e-19
M76482-1|AAA60230.1| 999|Homo sapiens pemphigus vulgaris antige... 99 2e-19
Z34522-2|CAA84279.1| 894|Homo sapiens Dsc1b precursor protein. 98 5e-19
>AL031597-2|CAI23555.1| 3014|Homo sapiens cadherin, EGF LAG seven-pass
G-type receptor 1 (flamingo homolog, Drosophila) protein.
Length = 3014
Score = 922 bits (2281), Expect = 0.0
Identities = 494/1116 (44%), Positives = 688/1116 (61%), Gaps = 73/1116 (6%)
Query: 13 VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNP 72
V D NDHSPVFE +Y VRE G VLT++A+D+D NA + Y +
Sbjct: 343 VKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRV---------- 392
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSS 132
DVF+++ SG + TRA LDRE+ A Y +LV+A DQ LS+
Sbjct: 393 ----------LGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGP-LSA 441
Query: 133 TATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII 192
TAT+++ + D+NDNYPQFSE+ Y V V ED+ + N + +++ATD D G N+AI Y+I+
Sbjct: 442 TATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL--NTAVLRVQATDRDQGQNAAIHYSIL 499
Query: 193 GGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRDVN 251
GN QF + SLSG + ++ LD+E V+ Y L I+AQDGG P N++ ++ + + DVN
Sbjct: 500 SGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVN 559
Query: 252 DNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD------------- 298
DN P F +S FQ +V ENVP+GY +V +QA DAD G NA L Y + D
Sbjct: 560 DNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGP 619
Query: 299 KDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
K+ D P I SGW+ +LDRE Y V A D G PP S++ +
Sbjct: 620 KNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLD 679
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN 418
F YE+ L ED G+ V+TL A D D ++ + Y++TGGNTR RF+++SQ
Sbjct: 680 VNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQR 739
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASV 478
G GLIT+A PLD+KQE++YVL V+A+D G RS TA V IN+TDAN + PVF+++ YT SV
Sbjct: 740 GGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQSSHYTVSV 798
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED P+GT++ +SA D D G NA+ITY + + QF I+P +G + T
Sbjct: 799 SEDRPVGTSIATLSANDEDTGENARITYVIQDPVP---------QFRIDPDSGTMYTMME 849
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LD E Y LT+ A+D G+P SDTT +EI ++D NDN P F Y +I EDA T
Sbjct: 850 LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPST 909
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAV 658
S+ QV ATD D G NGR+ Y D +G F I+P SGVIRT + LDRE+VA ++L A+
Sbjct: 910 SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWAL 969
Query: 659 AIDGGTP-PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A+D G+P P S++V + + I DIND+ P+FE D L ++ EN+P+G+ + +IRA+DPDEG
Sbjct: 970 AVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
PNA + Y I GD + F L+ G +L MV+LD+E R++Y LV++A S PL +
Sbjct: 1030 PNAQIMYQIVEGDMRHFFQLDLLNG----DLRAMVELDFEV-RREYVLVVQATSAPLVSR 1084
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILS 833
V IL+ D NDN PV+ DFQI+FNNY + FP G G +PA+D DV+D L Y +
Sbjct: 1085 ATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQ 1144
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLL 893
GN L+LL+ TG + LS L+ N P A MEVSV+DG++ + A L V +IT++ML
Sbjct: 1145 GNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLT 1204
Query: 894 NSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSA 953
NSITVRL +M+ E+FLSPLL F++G+AA++ K+++++F+VQ+DTDV+ NILNV+FSA
Sbjct: 1205 NSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSA 1264
Query: 954 RRPDAEVGVAGDPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEEC 1013
P GV G + L+E++YL+RT L ++T +VLPFDDNIC+ EPC N+ +C
Sbjct: 1265 LLPG---GVRGQ---FFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKC 1318
Query: 1014 LTVLKFGNASGFVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSIC 1073
++VL+F +++ F++S +VLFRPI+P+ C+CP GFTG CET + + G C
Sbjct: 1319 VSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRC 1378
Query: 1074 RSGSQCVARREGGILCQGCSIDAAYTTAVCELRARS 1109
RS REGG C+ C D +T CE+ ARS
Sbjct: 1379 RS-------REGGYTCE-CFED--FTGEHCEVDARS 1404
Score = 591 bits (1460), Expect = e-167
Identities = 319/903 (35%), Positives = 479/903 (53%), Gaps = 84/903 (9%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC+C E FTG +CE C +C++G CV GG C C Y
Sbjct: 1385 YTCECFEDFTGEHCEVDARSGRCA----NGVCKNGGTCVNLLIGGFHCV-CP-PGEYERP 1438
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
CE+ RSFP SF+TF GL++R + L FATQ +GLLLYNGR+NE+HDF+ALE+V
Sbjct: 1439 YCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVD 1498
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEIT--VEGNVGDGSWHTVEIEYFNRT------------ 1207
+ ++ +FS G + + V V DG WH+V+++Y+N+
Sbjct: 1499 EQ--------VQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPS 1550
Query: 1208 ----ITMILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTET-CHRFLDLTGPL 1262
+ +DDCD +++ D G Y+CA T+T + LDLTGPL
Sbjct: 1551 GEKMAVVTVDDCDTTMAVRFGKDIG-NYSCA-----------AQGTQTGSKKSLDLTGPL 1598
Query: 1263 QIGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPC 1322
+GG+PN+P F V N+ FVGC+ + +D K +D+ ++A+NGT GC +R+ C C
Sbjct: 1599 LLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRC 1658
Query: 1323 YNGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFNPLLRPIQLPWLNALS 1382
NG C + W+ Y+C+C GK+C + P F G+ ++S++ L I +PW L
Sbjct: 1659 QNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLM 1718
Query: 1383 IRTRQRDAFVMS----------IQLKSGLLHYSYNG-----ETMYLPMATLSDGAWHR-- 1425
RTR+ D+ +M +Q+ + L + + E++ L ++DG WH
Sbjct: 1719 FRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLL 1778
Query: 1426 IEIKWLGTD------ISVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDV 1479
IE+K + D +++T+DYG+ + + G + +++GG +
Sbjct: 1779 IELKNVKEDSEMKHLVTMTLDYGMDQNKAD-IGGMLPGLTVRSVVVGGASEDKVSVRRG- 1836
Query: 1480 GFFEGCIQDVRIG---TAQSLLN-RPTVRENVRDGCQSRADCMLSICPPYSKCVTSWDSS 1535
F GC+Q VR+G T + LN ++ V+DGC C S CPP S+C +W+
Sbjct: 1837 --FRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDY 1894
Query: 1536 TCTCEAGRVGPQCVSACELGPC-GAARCVPDQ-TPKGYSCACEPGYTLTTSGCIESGKEE 1593
+C C+ G +G CV AC L PC CV +P+GY C C P + C
Sbjct: 1895 SCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHY--GPYCENKLDLP 1952
Query: 1594 CPGGWWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSEN 1653
CP GWWG CGPC C V++G+ P CNK NG+C CKEN+YK CLPC C+ GS +
Sbjct: 1953 CPRGWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHS 2012
Query: 1654 SSCEAATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFG 1713
+C+ ATGQC C+PGVIGR C+ C N +AEVT GCEV+Y+GCP++F G+WWP+TKFG
Sbjct: 2013 RTCDMATGQCACKPGVIGRQCNRCDNPFAEVT-TLGCEVIYNGCPKAFEAGIWWPQTKFG 2071
Query: 1714 VETITDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTF 1773
CP GS G A R C K W P++FNCTT +F LR K+ E ++
Sbjct: 2072 QPAAVPCPKGSVGNAVRHCSGEKG--WLPPELFNCTTISFVDLRAMNEKLSRNETQVDGA 2129
Query: 1774 VGVRVAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLK 1833
+++ L +A +T L+G DV A +L ++ +E Q G +L +QD D+ +++
Sbjct: 2130 RALQLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIH 2189
Query: 1834 STNTILNVEYEREWKRIRELTGHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKDVVI 1893
S + +L W++I+ G A+LL ++ + Y + +A + TY PF IVT ++++
Sbjct: 2190 SGSALLAPATRAAWEQIQRSEGGTAQLL-RRLEGYFSNVARNVRRTYLRPFVIVTANMIL 2248
Query: 1894 SVD 1896
+VD
Sbjct: 2249 AVD 2251
Score = 348 bits (856), Expect = 1e-94
Identities = 278/877 (31%), Positives = 418/877 (47%), Gaps = 73/877 (8%)
Query: 23 FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAXXXXXXX 82
F M Y+ ++ E +GT +L L A G+ V Y +E L E +
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYME-----GLFDERS------- 292
Query: 83 XXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIID 142
+ FRID +GA+ T + LDRE + + VKA D ++P S+T I V + D
Sbjct: 293 ----RGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPR---SATTYITVLVKD 345
Query: 143 DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI 202
ND+ P F + Y V E++ V + I+A+D D N+ +RY ++GG + F +
Sbjct: 346 TNDHSPVFEQSEYRERVRENLEV--GYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQL 402
Query: 203 DSLSGDVSLVKTLDYEQVRSYRLVIRAQD-GGSPS-RSNTTQLLINIRDVNDNAPRFYTS 260
+ SG VS LD E+ Y+L++ A D G +P S T + I + D NDN P+F
Sbjct: 403 NESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQ 462
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
+ V E+V + +++RVQA D D+G NA + Y++ +GNV + SG +
Sbjct: 463 NYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI----LSGNVAGQFYLHSLSGILDV 518
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPR-SATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
LD E KY L + A DGG PP +++ F+ ++ + E+
Sbjct: 519 INPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENV 578
Query: 380 PPGTPVVTLTATDAD--EDNRLHYEIT-------GGNTRG--------RFSITSQNGRGL 422
P G PVV + A DAD E+ RLHY + GG + G F N G
Sbjct: 579 PLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGW 638
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
ITV LD ++ Y V A D G S + V I + D N+ PVF Y + E
Sbjct: 639 ITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNE 698
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
DA +G++VL + A D D N+ ITY L+ + A Q+ G IT LD
Sbjct: 699 DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQR-----GGGLITLALPLD 751
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
+ Y+L VTA DG + S T V I+V D N + PVF+ YT ++ ED VGTS+
Sbjct: 752 YKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSI 808
Query: 601 SQVGATDADVGLNGRIHYEL-DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+ + A D D G N RI Y + DP + F IDP SG + T LD E+ + L +A
Sbjct: 809 ATLSANDEDTGENARITYVIQDPVPQ----FRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G P +S T + I I D ND+ P F D I E++P T+I ++ A D D GPN
Sbjct: 865 QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
Query: 720 AVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASP-PLWND 777
+ Y+ +GGDD + F +E G + + +D + + + L + SP PL
Sbjct: 925 GRLLYTFQGGDDGDGDFYIEPTSGVIRTQ--RRLDRENVAVYNLWALAVDRGSPTPLSAS 982
Query: 778 VRVEILVTDVNDNAPVM-KDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILS 833
V +++ + D+NDNAP+ KD +F ++ PVG ++ A D D ++ Y+I+
Sbjct: 983 VEIQVTILDINDNAPMFEKDELELF--VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE 1040
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVT 870
G+ + L+ G + +L+ V + + V T
Sbjct: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT 1077
Score = 310 bits (761), Expect = 5e-83
Identities = 246/776 (31%), Positives = 379/776 (48%), Gaps = 78/776 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND+ P F Q Y V E T VL ++ATD+D G+NA + Y+I
Sbjct: 447 IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI-------- 498
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V F + SG L LD E V +Y++ +KA D P +
Sbjct: 499 -----------LSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP--PLI 545
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+ + V ++D NDN P F + +V E++ + PV+ I+A DAD G N+ + Y
Sbjct: 546 NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPL-GYPVV-HIQAVDADSGENARLHYR 603
Query: 191 II-------GGNT----------QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGG 233
++ GG + F I + SG +++ LD E+V Y + A D G
Sbjct: 604 LVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG 663
Query: 234 SPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELT 293
SP S++T + I + DVNDN P F ++ ++E+ +G S++ +QA D D N+ +T
Sbjct: 664 SPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVIT 721
Query: 294 YTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXX 353
Y +T + T N ++ G + + LD + + +Y L VTA+DG RS TA
Sbjct: 722 YQLTGGN-TRN-RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVL 776
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR 411
F Y V ++ED P GT + TL+A D D E+ R+ Y I + +
Sbjct: 777 INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQ 834
Query: 412 FSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF 469
F I +G + T+ + LD++ + Y LT+ A D+G +SDT ++I I DAN+ AP F
Sbjct: 835 FRIDPDSGT-MYTMME-LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
Y S+FEDAP T++L VSATD D G N ++ Y+ D F I P
Sbjct: 893 LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDG------DGDFYIEPT 946
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTA 588
+G I T + LDRE ++ Y L A D G P+ LS + +++++++D+NDN P+F++
Sbjct: 947 SGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
+ E+ VG+ V+++ A D D G N +I Y++ D F +D +G +R LD E
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRH-FFQLDLLNGDLRAMVELDFE 1065
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF--YISENS---PIG 703
+ + + + P S VHI + D ND+PPV + F Y++ S P G
Sbjct: 1066 VRREY---VLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
IG I AHDPD + ++Y+ G++ L+ G EL DLD P
Sbjct: 1123 -VIGCIPAHDPDVSDS--LNYTFVQGNELRLLLLDPATG----ELQLSRDLDNNRP 1171
Score = 289 bits (708), Expect = 1e-76
Identities = 219/683 (32%), Positives = 332/683 (48%), Gaps = 46/683 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ P+F ++A+V E G V+ ++A D D G+NA + Y + + L
Sbjct: 553 VQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
A F+I SG + A LDRE+V Y+ V+A D SP +
Sbjct: 613 GGGSAGPKNPAPTPDFP--FQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP---PM 667
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SS+ ++ + ++D NDN P F++ TY + ++ED +V + + ++A D D ANS I Y
Sbjct: 668 SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSS--VLTLQARDRD--ANSVITYQ 723
Query: 191 IIGGNTQMQFSIDSLSGD--VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
+ GGNT+ +F++ S G ++L LDY+Q + Y L + A DG +RS+T +LIN+
Sbjct: 724 LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVT 780
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D N + P F +S + SVSE+ P+G SI + A D D G NA +TY + D +P
Sbjct: 781 DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD-------PVP 833
Query: 309 -ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
IDP SG +YT +LD E Q Y L + A D G P +S T T F+
Sbjct: 834 QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNT-RGRFSITSQNGRGLIT 424
Y+ + ED PP T ++ ++ATD D + RL Y GG+ G F I + G+I
Sbjct: 894 WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS--GVIR 951
Query: 425 VAQPLDFKQERRYVLTVSATDSGG---RSDTAMVQINITDANNYAPVFENAPYTASVFED 481
+ LD + Y L A D G S + +Q+ I D N+ AP+FE V E+
Sbjct: 952 TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEEN 1011
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
P+G+ V + A D D G NAQI Y +I + H Q ++N A+ LD
Sbjct: 1012 NPVGSVVAKIRANDPDEGPNAQIMY----QIVEGDMRHFFQLDLLNGDLRAMVE---LDF 1064
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ-QLYTANIMEDALVGTSV 600
E Y+L V A P +S T V I +VD NDN PV Q+ N + +
Sbjct: 1065 EVRREYVLVVQAT--SAPLVSRAT-VHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121
Query: 601 SQVGATDA-DVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+G A D ++ ++Y + E ++DPA+G ++ ++ LD L V+
Sbjct: 1122 GVIGCIPAHDPDVSDSLNYTF-VQGNELRLLLLDPATGELQLSRDLDNNR-PLEALMEVS 1179
Query: 660 IDGGTPPQSSTVIVHIKIEDIND 682
+ G S T +++ I D
Sbjct: 1180 VSDGI--HSVTAFCTLRVTIITD 1200
Score = 177 bits (430), Expect = 6e-43
Identities = 139/457 (30%), Positives = 208/457 (45%), Gaps = 38/457 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H INV D N H PVF+ Y SV E GT++ TL A D+D G+NA + Y I+
Sbjct: 774 HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ---- 829
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
D + P+ FRID SG + T LD E YT+ + A D P
Sbjct: 830 DPV-PQ----------------FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-- 870
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
+ S T T+ + I+D NDN PQF Y S+ ED + + I ++ ATD D G N +
Sbjct: 871 -QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTS--ILQVSATDRDSGPNGRL 927
Query: 188 RYAIIGGNT-QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS-RSNTTQLLI 245
Y GG+ F I+ SG + + LD E V Y L A D GSP+ S + ++ +
Sbjct: 928 LYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQV 987
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D+NDNAP F + V EN P+G + +++A D DEG NA++ Y + + G++
Sbjct: 988 TILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE----GDM 1043
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+D +G + +LD E + +Y L+V AT R+
Sbjct: 1044 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPD 1103
Query: 366 F--MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLI 423
F + Y + P G + + A D D + L+Y GN + G +
Sbjct: 1104 FQILFNNYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGE--L 1160
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT 460
+++ LD + ++ VS +D G S TA + +T
Sbjct: 1161 QLSRDLDNNRPLEALMEVSVSD-GIHSVTAFCTLRVT 1196
Score = 112 bits (270), Expect = 2e-23
Identities = 91/301 (30%), Positives = 136/301 (45%), Gaps = 15/301 (4%)
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDP--KDREEGSFVIDPASGV 638
F Y + E+ GT + Q+ A G R+ Y ++ +R G F ID A+G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 639 IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISE 698
+ T+ LDRE+ TH L+ A+D TPP+S+T + + ++D ND PVFE + E
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
Query: 699 NSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES 758
N +G + IRA D D NA + Y + GG + F L G + T LD E
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSG----VVSTRAVLDREE 419
Query: 759 PRKKYELVIRA----ASP-PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF 813
+Y+L++ A +P PL V I V D NDN P + + +D
Sbjct: 420 -AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
Query: 814 GRVPAYDADVTDK--LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
RV A D D + Y ILSGN A L+ +G + + L+ + ++ + D
Sbjct: 479 LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
Query: 872 G 872
G
Sbjct: 539 G 539
Score = 68.5 bits (160), Expect = 3e-10
Identities = 47/151 (31%), Positives = 78/151 (51%), Gaps = 14/151 (9%)
Query: 2173 GIRLKKPIRLQIWLDINRETFGSRTNPQCVHWS---TLRGSGEWSRVGCHTEIDYDWSPY 2229
G L +P+ + ++ RT P CV W+ + G+G WS GC
Sbjct: 2383 GAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCEL--------L 2434
Query: 2230 SEEPLLINCTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCL 2289
S + C C+H ++FAVL+D + E L+ VT Y A S+SL LL ++ L L
Sbjct: 2435 SRNRTHVACQCSHTASFAVLMD-ISRRENGEVLPLKIVT-YAAVSLSLAALLVAFVLLSL 2492
Query: 2290 IRGGAATVSNSIHKHLIFSVFMAELLYLIAL 2320
+R + + +SIHKHL ++F+++L+++I +
Sbjct: 2493 VRMLRSNL-HSIHKHLAVALFLSQLVFVIGI 2522
>AL031588-3|CAI19319.1| 3014|Homo sapiens cadherin, EGF LAG seven-pass
G-type receptor 1 (flamingo homolog, Drosophila) protein.
Length = 3014
Score = 922 bits (2281), Expect = 0.0
Identities = 494/1116 (44%), Positives = 688/1116 (61%), Gaps = 73/1116 (6%)
Query: 13 VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNP 72
V D NDHSPVFE +Y VRE G VLT++A+D+D NA + Y +
Sbjct: 343 VKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRV---------- 392
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSS 132
DVF+++ SG + TRA LDRE+ A Y +LV+A DQ LS+
Sbjct: 393 ----------LGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGP-LSA 441
Query: 133 TATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII 192
TAT+++ + D+NDNYPQFSE+ Y V V ED+ + N + +++ATD D G N+AI Y+I+
Sbjct: 442 TATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL--NTAVLRVQATDRDQGQNAAIHYSIL 499
Query: 193 GGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRDVN 251
GN QF + SLSG + ++ LD+E V+ Y L I+AQDGG P N++ ++ + + DVN
Sbjct: 500 SGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVN 559
Query: 252 DNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD------------- 298
DN P F +S FQ +V ENVP+GY +V +QA DAD G NA L Y + D
Sbjct: 560 DNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGP 619
Query: 299 KDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
K+ D P I SGW+ +LDRE Y V A D G PP S++ +
Sbjct: 620 KNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLD 679
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN 418
F YE+ L ED G+ V+TL A D D ++ + Y++TGGNTR RF+++SQ
Sbjct: 680 VNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQR 739
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASV 478
G GLIT+A PLD+KQE++YVL V+A+D G RS TA V IN+TDAN + PVF+++ YT SV
Sbjct: 740 GGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQSSHYTVSV 798
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED P+GT++ +SA D D G NA+ITY + + QF I+P +G + T
Sbjct: 799 SEDRPVGTSIATLSANDEDTGENARITYVIQDPVP---------QFRIDPDSGTMYTMME 849
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LD E Y LT+ A+D G+P SDTT +EI ++D NDN P F Y +I EDA T
Sbjct: 850 LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPST 909
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAV 658
S+ QV ATD D G NGR+ Y D +G F I+P SGVIRT + LDRE+VA ++L A+
Sbjct: 910 SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWAL 969
Query: 659 AIDGGTP-PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A+D G+P P S++V + + I DIND+ P+FE D L ++ EN+P+G+ + +IRA+DPDEG
Sbjct: 970 AVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
PNA + Y I GD + F L+ G +L MV+LD+E R++Y LV++A S PL +
Sbjct: 1030 PNAQIMYQIVEGDMRHFFQLDLLNG----DLRAMVELDFEV-RREYVLVVQATSAPLVSR 1084
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILS 833
V IL+ D NDN PV+ DFQI+FNNY + FP G G +PA+D DV+D L Y +
Sbjct: 1085 ATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQ 1144
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLL 893
GN L+LL+ TG + LS L+ N P A MEVSV+DG++ + A L V +IT++ML
Sbjct: 1145 GNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLT 1204
Query: 894 NSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSA 953
NSITVRL +M+ E+FLSPLL F++G+AA++ K+++++F+VQ+DTDV+ NILNV+FSA
Sbjct: 1205 NSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSA 1264
Query: 954 RRPDAEVGVAGDPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEEC 1013
P GV G + L+E++YL+RT L ++T +VLPFDDNIC+ EPC N+ +C
Sbjct: 1265 LLPG---GVRGQ---FFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKC 1318
Query: 1014 LTVLKFGNASGFVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSIC 1073
++VL+F +++ F++S +VLFRPI+P+ C+CP GFTG CET + + G C
Sbjct: 1319 VSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRC 1378
Query: 1074 RSGSQCVARREGGILCQGCSIDAAYTTAVCELRARS 1109
RS REGG C+ C D +T CE+ ARS
Sbjct: 1379 RS-------REGGYTCE-CFED--FTGEHCEVDARS 1404
Score = 591 bits (1460), Expect = e-167
Identities = 319/903 (35%), Positives = 479/903 (53%), Gaps = 84/903 (9%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC+C E FTG +CE C +C++G CV GG C C Y
Sbjct: 1385 YTCECFEDFTGEHCEVDARSGRCA----NGVCKNGGTCVNLLIGGFHCV-CP-PGEYERP 1438
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
CE+ RSFP SF+TF GL++R + L FATQ +GLLLYNGR+NE+HDF+ALE+V
Sbjct: 1439 YCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVD 1498
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEIT--VEGNVGDGSWHTVEIEYFNRT------------ 1207
+ ++ +FS G + + V V DG WH+V+++Y+N+
Sbjct: 1499 EQ--------VQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPS 1550
Query: 1208 ----ITMILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTET-CHRFLDLTGPL 1262
+ +DDCD +++ D G Y+CA T+T + LDLTGPL
Sbjct: 1551 GEKMAVVTVDDCDTTMAVRFGKDIG-NYSCA-----------AQGTQTGSKKSLDLTGPL 1598
Query: 1263 QIGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPC 1322
+GG+PN+P F V N+ FVGC+ + +D K +D+ ++A+NGT GC +R+ C C
Sbjct: 1599 LLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRC 1658
Query: 1323 YNGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFNPLLRPIQLPWLNALS 1382
NG C + W+ Y+C+C GK+C + P F G+ ++S++ L I +PW L
Sbjct: 1659 QNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLM 1718
Query: 1383 IRTRQRDAFVMS----------IQLKSGLLHYSYNG-----ETMYLPMATLSDGAWHR-- 1425
RTR+ D+ +M +Q+ + L + + E++ L ++DG WH
Sbjct: 1719 FRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLL 1778
Query: 1426 IEIKWLGTD------ISVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDV 1479
IE+K + D +++T+DYG+ + + G + +++GG +
Sbjct: 1779 IELKNVKEDSEMKHLVTMTLDYGMDQNKAD-IGGMLPGLTVRSVVVGGASEDKVSVRRG- 1836
Query: 1480 GFFEGCIQDVRIG---TAQSLLN-RPTVRENVRDGCQSRADCMLSICPPYSKCVTSWDSS 1535
F GC+Q VR+G T + LN ++ V+DGC C S CPP S+C +W+
Sbjct: 1837 --FRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDY 1894
Query: 1536 TCTCEAGRVGPQCVSACELGPC-GAARCVPDQ-TPKGYSCACEPGYTLTTSGCIESGKEE 1593
+C C+ G +G CV AC L PC CV +P+GY C C P + C
Sbjct: 1895 SCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHY--GPYCENKLDLP 1952
Query: 1594 CPGGWWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSEN 1653
CP GWWG CGPC C V++G+ P CNK NG+C CKEN+YK CLPC C+ GS +
Sbjct: 1953 CPRGWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHS 2012
Query: 1654 SSCEAATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFG 1713
+C+ ATGQC C+PGVIGR C+ C N +AEVT GCEV+Y+GCP++F G+WWP+TKFG
Sbjct: 2013 RTCDMATGQCACKPGVIGRQCNRCDNPFAEVT-TLGCEVIYNGCPKAFEAGIWWPQTKFG 2071
Query: 1714 VETITDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTF 1773
CP GS G A R C K W P++FNCTT +F LR K+ E ++
Sbjct: 2072 QPAAVPCPKGSVGNAVRHCSGEKG--WLPPELFNCTTISFVDLRAMNEKLSRNETQVDGA 2129
Query: 1774 VGVRVAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLK 1833
+++ L +A +T L+G DV A +L ++ +E Q G +L +QD D+ +++
Sbjct: 2130 RALQLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIH 2189
Query: 1834 STNTILNVEYEREWKRIRELTGHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKDVVI 1893
S + +L W++I+ G A+LL ++ + Y + +A + TY PF IVT ++++
Sbjct: 2190 SGSALLAPATRAAWEQIQRSEGGTAQLL-RRLEGYFSNVARNVRRTYLRPFVIVTANMIL 2248
Query: 1894 SVD 1896
+VD
Sbjct: 2249 AVD 2251
Score = 348 bits (856), Expect = 1e-94
Identities = 278/877 (31%), Positives = 418/877 (47%), Gaps = 73/877 (8%)
Query: 23 FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAXXXXXXX 82
F M Y+ ++ E +GT +L L A G+ V Y +E L E +
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYME-----GLFDERS------- 292
Query: 83 XXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIID 142
+ FRID +GA+ T + LDRE + + VKA D ++P S+T I V + D
Sbjct: 293 ----RGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPR---SATTYITVLVKD 345
Query: 143 DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI 202
ND+ P F + Y V E++ V + I+A+D D N+ +RY ++GG + F +
Sbjct: 346 TNDHSPVFEQSEYRERVRENLEV--GYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQL 402
Query: 203 DSLSGDVSLVKTLDYEQVRSYRLVIRAQD-GGSPS-RSNTTQLLINIRDVNDNAPRFYTS 260
+ SG VS LD E+ Y+L++ A D G +P S T + I + D NDN P+F
Sbjct: 403 NESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQ 462
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
+ V E+V + +++RVQA D D+G NA + Y++ +GNV + SG +
Sbjct: 463 NYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI----LSGNVAGQFYLHSLSGILDV 518
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPR-SATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
LD E KY L + A DGG PP +++ F+ ++ + E+
Sbjct: 519 INPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENV 578
Query: 380 PPGTPVVTLTATDAD--EDNRLHYEIT-------GGNTRG--------RFSITSQNGRGL 422
P G PVV + A DAD E+ RLHY + GG + G F N G
Sbjct: 579 PLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGW 638
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
ITV LD ++ Y V A D G S + V I + D N+ PVF Y + E
Sbjct: 639 ITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNE 698
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
DA +G++VL + A D D N+ ITY L+ + A Q+ G IT LD
Sbjct: 699 DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQR-----GGGLITLALPLD 751
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
+ Y+L VTA DG + S T V I+V D N + PVF+ YT ++ ED VGTS+
Sbjct: 752 YKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSI 808
Query: 601 SQVGATDADVGLNGRIHYEL-DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+ + A D D G N RI Y + DP + F IDP SG + T LD E+ + L +A
Sbjct: 809 ATLSANDEDTGENARITYVIQDPVPQ----FRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G P +S T + I I D ND+ P F D I E++P T+I ++ A D D GPN
Sbjct: 865 QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
Query: 720 AVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASP-PLWND 777
+ Y+ +GGDD + F +E G + + +D + + + L + SP PL
Sbjct: 925 GRLLYTFQGGDDGDGDFYIEPTSGVIRTQ--RRLDRENVAVYNLWALAVDRGSPTPLSAS 982
Query: 778 VRVEILVTDVNDNAPVM-KDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILS 833
V +++ + D+NDNAP+ KD +F ++ PVG ++ A D D ++ Y+I+
Sbjct: 983 VEIQVTILDINDNAPMFEKDELELF--VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE 1040
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVT 870
G+ + L+ G + +L+ V + + V T
Sbjct: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT 1077
Score = 310 bits (761), Expect = 5e-83
Identities = 246/776 (31%), Positives = 379/776 (48%), Gaps = 78/776 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND+ P F Q Y V E T VL ++ATD+D G+NA + Y+I
Sbjct: 447 IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI-------- 498
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V F + SG L LD E V +Y++ +KA D P +
Sbjct: 499 -----------LSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP--PLI 545
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+ + V ++D NDN P F + +V E++ + PV+ I+A DAD G N+ + Y
Sbjct: 546 NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPL-GYPVV-HIQAVDADSGENARLHYR 603
Query: 191 II-------GGNT----------QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGG 233
++ GG + F I + SG +++ LD E+V Y + A D G
Sbjct: 604 LVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG 663
Query: 234 SPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELT 293
SP S++T + I + DVNDN P F ++ ++E+ +G S++ +QA D D N+ +T
Sbjct: 664 SPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVIT 721
Query: 294 YTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXX 353
Y +T + T N ++ G + + LD + + +Y L VTA+DG RS TA
Sbjct: 722 YQLTGGN-TRN-RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVL 776
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR 411
F Y V ++ED P GT + TL+A D D E+ R+ Y I + +
Sbjct: 777 INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQ 834
Query: 412 FSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF 469
F I +G + T+ + LD++ + Y LT+ A D+G +SDT ++I I DAN+ AP F
Sbjct: 835 FRIDPDSGT-MYTMME-LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
Y S+FEDAP T++L VSATD D G N ++ Y+ D F I P
Sbjct: 893 LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDG------DGDFYIEPT 946
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTA 588
+G I T + LDRE ++ Y L A D G P+ LS + +++++++D+NDN P+F++
Sbjct: 947 SGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
+ E+ VG+ V+++ A D D G N +I Y++ D F +D +G +R LD E
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRH-FFQLDLLNGDLRAMVELDFE 1065
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF--YISENS---PIG 703
+ + + + P S VHI + D ND+PPV + F Y++ S P G
Sbjct: 1066 VRREY---VLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
IG I AHDPD + ++Y+ G++ L+ G EL DLD P
Sbjct: 1123 -VIGCIPAHDPDVSDS--LNYTFVQGNELRLLLLDPATG----ELQLSRDLDNNRP 1171
Score = 289 bits (708), Expect = 1e-76
Identities = 219/683 (32%), Positives = 332/683 (48%), Gaps = 46/683 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ P+F ++A+V E G V+ ++A D D G+NA + Y + + L
Sbjct: 553 VQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
A F+I SG + A LDRE+V Y+ V+A D SP +
Sbjct: 613 GGGSAGPKNPAPTPDFP--FQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP---PM 667
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SS+ ++ + ++D NDN P F++ TY + ++ED +V + + ++A D D ANS I Y
Sbjct: 668 SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSS--VLTLQARDRD--ANSVITYQ 723
Query: 191 IIGGNTQMQFSIDSLSGD--VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
+ GGNT+ +F++ S G ++L LDY+Q + Y L + A DG +RS+T +LIN+
Sbjct: 724 LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVT 780
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D N + P F +S + SVSE+ P+G SI + A D D G NA +TY + D +P
Sbjct: 781 DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD-------PVP 833
Query: 309 -ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
IDP SG +YT +LD E Q Y L + A D G P +S T T F+
Sbjct: 834 QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNT-RGRFSITSQNGRGLIT 424
Y+ + ED PP T ++ ++ATD D + RL Y GG+ G F I + G+I
Sbjct: 894 WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS--GVIR 951
Query: 425 VAQPLDFKQERRYVLTVSATDSGG---RSDTAMVQINITDANNYAPVFENAPYTASVFED 481
+ LD + Y L A D G S + +Q+ I D N+ AP+FE V E+
Sbjct: 952 TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEEN 1011
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
P+G+ V + A D D G NAQI Y +I + H Q ++N A+ LD
Sbjct: 1012 NPVGSVVAKIRANDPDEGPNAQIMY----QIVEGDMRHFFQLDLLNGDLRAMVE---LDF 1064
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ-QLYTANIMEDALVGTSV 600
E Y+L V A P +S T V I +VD NDN PV Q+ N + +
Sbjct: 1065 EVRREYVLVVQAT--SAPLVSRAT-VHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121
Query: 601 SQVGATDA-DVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+G A D ++ ++Y + E ++DPA+G ++ ++ LD L V+
Sbjct: 1122 GVIGCIPAHDPDVSDSLNYTF-VQGNELRLLLLDPATGELQLSRDLDNNR-PLEALMEVS 1179
Query: 660 IDGGTPPQSSTVIVHIKIEDIND 682
+ G S T +++ I D
Sbjct: 1180 VSDGI--HSVTAFCTLRVTIITD 1200
Score = 177 bits (430), Expect = 6e-43
Identities = 139/457 (30%), Positives = 208/457 (45%), Gaps = 38/457 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H INV D N H PVF+ Y SV E GT++ TL A D+D G+NA + Y I+
Sbjct: 774 HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ---- 829
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
D + P+ FRID SG + T LD E YT+ + A D P
Sbjct: 830 DPV-PQ----------------FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-- 870
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
+ S T T+ + I+D NDN PQF Y S+ ED + + I ++ ATD D G N +
Sbjct: 871 -QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTS--ILQVSATDRDSGPNGRL 927
Query: 188 RYAIIGGNT-QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS-RSNTTQLLI 245
Y GG+ F I+ SG + + LD E V Y L A D GSP+ S + ++ +
Sbjct: 928 LYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQV 987
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D+NDNAP F + V EN P+G + +++A D DEG NA++ Y + + G++
Sbjct: 988 TILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE----GDM 1043
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+D +G + +LD E + +Y L+V AT R+
Sbjct: 1044 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPD 1103
Query: 366 F--MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLI 423
F + Y + P G + + A D D + L+Y GN + G +
Sbjct: 1104 FQILFNNYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGE--L 1160
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT 460
+++ LD + ++ VS +D G S TA + +T
Sbjct: 1161 QLSRDLDNNRPLEALMEVSVSD-GIHSVTAFCTLRVT 1196
Score = 112 bits (270), Expect = 2e-23
Identities = 91/301 (30%), Positives = 136/301 (45%), Gaps = 15/301 (4%)
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDP--KDREEGSFVIDPASGV 638
F Y + E+ GT + Q+ A G R+ Y ++ +R G F ID A+G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 639 IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISE 698
+ T+ LDRE+ TH L+ A+D TPP+S+T + + ++D ND PVFE + E
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
Query: 699 NSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES 758
N +G + IRA D D NA + Y + GG + F L G + T LD E
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSG----VVSTRAVLDREE 419
Query: 759 PRKKYELVIRA----ASP-PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF 813
+Y+L++ A +P PL V I V D NDN P + + +D
Sbjct: 420 -AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
Query: 814 GRVPAYDADVTDK--LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
RV A D D + Y ILSGN A L+ +G + + L+ + ++ + D
Sbjct: 479 LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
Query: 872 G 872
G
Sbjct: 539 G 539
Score = 68.5 bits (160), Expect = 3e-10
Identities = 47/151 (31%), Positives = 78/151 (51%), Gaps = 14/151 (9%)
Query: 2173 GIRLKKPIRLQIWLDINRETFGSRTNPQCVHWS---TLRGSGEWSRVGCHTEIDYDWSPY 2229
G L +P+ + ++ RT P CV W+ + G+G WS GC
Sbjct: 2383 GAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCEL--------L 2434
Query: 2230 SEEPLLINCTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCL 2289
S + C C+H ++FAVL+D + E L+ VT Y A S+SL LL ++ L L
Sbjct: 2435 SRNRTHVACQCSHTASFAVLMD-ISRRENGEVLPLKIVT-YAAVSLSLAALLVAFVLLSL 2492
Query: 2290 IRGGAATVSNSIHKHLIFSVFMAELLYLIAL 2320
+R + + +SIHKHL ++F+++L+++I +
Sbjct: 2493 VRMLRSNL-HSIHKHLAVALFLSQLVFVIGI 2522
>AL021392-2|CAI20967.1| 3014|Homo sapiens cadherin, EGF LAG seven-pass
G-type receptor 1 (flamingo homolog, Drosophila) protein.
Length = 3014
Score = 922 bits (2281), Expect = 0.0
Identities = 494/1116 (44%), Positives = 688/1116 (61%), Gaps = 73/1116 (6%)
Query: 13 VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNP 72
V D NDHSPVFE +Y VRE G VLT++A+D+D NA + Y +
Sbjct: 343 VKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRV---------- 392
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSS 132
DVF+++ SG + TRA LDRE+ A Y +LV+A DQ LS+
Sbjct: 393 ----------LGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGP-LSA 441
Query: 133 TATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII 192
TAT+++ + D+NDNYPQFSE+ Y V V ED+ + N + +++ATD D G N+AI Y+I+
Sbjct: 442 TATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL--NTAVLRVQATDRDQGQNAAIHYSIL 499
Query: 193 GGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRDVN 251
GN QF + SLSG + ++ LD+E V+ Y L I+AQDGG P N++ ++ + + DVN
Sbjct: 500 SGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVN 559
Query: 252 DNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD------------- 298
DN P F +S FQ +V ENVP+GY +V +QA DAD G NA L Y + D
Sbjct: 560 DNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGP 619
Query: 299 KDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
K+ D P I SGW+ +LDRE Y V A D G PP S++ +
Sbjct: 620 KNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLD 679
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN 418
F YE+ L ED G+ V+TL A D D ++ + Y++TGGNTR RF+++SQ
Sbjct: 680 VNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQR 739
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASV 478
G GLIT+A PLD+KQE++YVL V+A+D G RS TA V IN+TDAN + PVF+++ YT SV
Sbjct: 740 GGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQSSHYTVSV 798
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED P+GT++ +SA D D G NA+ITY + + QF I+P +G + T
Sbjct: 799 SEDRPVGTSIATLSANDEDTGENARITYVIQDPVP---------QFRIDPDSGTMYTMME 849
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LD E Y LT+ A+D G+P SDTT +EI ++D NDN P F Y +I EDA T
Sbjct: 850 LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPST 909
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAV 658
S+ QV ATD D G NGR+ Y D +G F I+P SGVIRT + LDRE+VA ++L A+
Sbjct: 910 SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWAL 969
Query: 659 AIDGGTP-PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A+D G+P P S++V + + I DIND+ P+FE D L ++ EN+P+G+ + +IRA+DPDEG
Sbjct: 970 AVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
PNA + Y I GD + F L+ G +L MV+LD+E R++Y LV++A S PL +
Sbjct: 1030 PNAQIMYQIVEGDMRHFFQLDLLNG----DLRAMVELDFEV-RREYVLVVQATSAPLVSR 1084
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILS 833
V IL+ D NDN PV+ DFQI+FNNY + FP G G +PA+D DV+D L Y +
Sbjct: 1085 ATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQ 1144
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLL 893
GN L+LL+ TG + LS L+ N P A MEVSV+DG++ + A L V +IT++ML
Sbjct: 1145 GNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLT 1204
Query: 894 NSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSA 953
NSITVRL +M+ E+FLSPLL F++G+AA++ K+++++F+VQ+DTDV+ NILNV+FSA
Sbjct: 1205 NSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSA 1264
Query: 954 RRPDAEVGVAGDPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEEC 1013
P GV G + L+E++YL+RT L ++T +VLPFDDNIC+ EPC N+ +C
Sbjct: 1265 LLPG---GVRGQ---FFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKC 1318
Query: 1014 LTVLKFGNASGFVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSIC 1073
++VL+F +++ F++S +VLFRPI+P+ C+CP GFTG CET + + G C
Sbjct: 1319 VSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRC 1378
Query: 1074 RSGSQCVARREGGILCQGCSIDAAYTTAVCELRARS 1109
RS REGG C+ C D +T CE+ ARS
Sbjct: 1379 RS-------REGGYTCE-CFED--FTGEHCEVDARS 1404
Score = 591 bits (1460), Expect = e-167
Identities = 319/903 (35%), Positives = 479/903 (53%), Gaps = 84/903 (9%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC+C E FTG +CE C +C++G CV GG C C Y
Sbjct: 1385 YTCECFEDFTGEHCEVDARSGRCA----NGVCKNGGTCVNLLIGGFHCV-CP-PGEYERP 1438
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
CE+ RSFP SF+TF GL++R + L FATQ +GLLLYNGR+NE+HDF+ALE+V
Sbjct: 1439 YCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVD 1498
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEIT--VEGNVGDGSWHTVEIEYFNRT------------ 1207
+ ++ +FS G + + V V DG WH+V+++Y+N+
Sbjct: 1499 EQ--------VQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPS 1550
Query: 1208 ----ITMILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTET-CHRFLDLTGPL 1262
+ +DDCD +++ D G Y+CA T+T + LDLTGPL
Sbjct: 1551 GEKMAVVTVDDCDTTMAVRFGKDIG-NYSCA-----------AQGTQTGSKKSLDLTGPL 1598
Query: 1263 QIGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPC 1322
+GG+PN+P F V N+ FVGC+ + +D K +D+ ++A+NGT GC +R+ C C
Sbjct: 1599 LLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRC 1658
Query: 1323 YNGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFNPLLRPIQLPWLNALS 1382
NG C + W+ Y+C+C GK+C + P F G+ ++S++ L I +PW L
Sbjct: 1659 QNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLM 1718
Query: 1383 IRTRQRDAFVMS----------IQLKSGLLHYSYNG-----ETMYLPMATLSDGAWHR-- 1425
RTR+ D+ +M +Q+ + L + + E++ L ++DG WH
Sbjct: 1719 FRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLL 1778
Query: 1426 IEIKWLGTD------ISVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDV 1479
IE+K + D +++T+DYG+ + + G + +++GG +
Sbjct: 1779 IELKNVKEDSEMKHLVTMTLDYGMDQNKAD-IGGMLPGLTVRSVVVGGASEDKVSVRRG- 1836
Query: 1480 GFFEGCIQDVRIG---TAQSLLN-RPTVRENVRDGCQSRADCMLSICPPYSKCVTSWDSS 1535
F GC+Q VR+G T + LN ++ V+DGC C S CPP S+C +W+
Sbjct: 1837 --FRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDY 1894
Query: 1536 TCTCEAGRVGPQCVSACELGPC-GAARCVPDQ-TPKGYSCACEPGYTLTTSGCIESGKEE 1593
+C C+ G +G CV AC L PC CV +P+GY C C P + C
Sbjct: 1895 SCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHY--GPYCENKLDLP 1952
Query: 1594 CPGGWWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSEN 1653
CP GWWG CGPC C V++G+ P CNK NG+C CKEN+YK CLPC C+ GS +
Sbjct: 1953 CPRGWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHS 2012
Query: 1654 SSCEAATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFG 1713
+C+ ATGQC C+PGVIGR C+ C N +AEVT GCEV+Y+GCP++F G+WWP+TKFG
Sbjct: 2013 RTCDMATGQCACKPGVIGRQCNRCDNPFAEVT-TLGCEVIYNGCPKAFEAGIWWPQTKFG 2071
Query: 1714 VETITDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTF 1773
CP GS G A R C K W P++FNCTT +F LR K+ E ++
Sbjct: 2072 QPAAVPCPKGSVGNAVRHCSGEKG--WLPPELFNCTTISFVDLRAMNEKLSRNETQVDGA 2129
Query: 1774 VGVRVAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLK 1833
+++ L +A +T L+G DV A +L ++ +E Q G +L +QD D+ +++
Sbjct: 2130 RALQLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIH 2189
Query: 1834 STNTILNVEYEREWKRIRELTGHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKDVVI 1893
S + +L W++I+ G A+LL ++ + Y + +A + TY PF IVT ++++
Sbjct: 2190 SGSALLAPATRAAWEQIQRSEGGTAQLL-RRLEGYFSNVARNVRRTYLRPFVIVTANMIL 2248
Query: 1894 SVD 1896
+VD
Sbjct: 2249 AVD 2251
Score = 348 bits (856), Expect = 1e-94
Identities = 278/877 (31%), Positives = 418/877 (47%), Gaps = 73/877 (8%)
Query: 23 FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAXXXXXXX 82
F M Y+ ++ E +GT +L L A G+ V Y +E L E +
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYME-----GLFDERS------- 292
Query: 83 XXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIID 142
+ FRID +GA+ T + LDRE + + VKA D ++P S+T I V + D
Sbjct: 293 ----RGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPR---SATTYITVLVKD 345
Query: 143 DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI 202
ND+ P F + Y V E++ V + I+A+D D N+ +RY ++GG + F +
Sbjct: 346 TNDHSPVFEQSEYRERVRENLEV--GYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQL 402
Query: 203 DSLSGDVSLVKTLDYEQVRSYRLVIRAQD-GGSPS-RSNTTQLLINIRDVNDNAPRFYTS 260
+ SG VS LD E+ Y+L++ A D G +P S T + I + D NDN P+F
Sbjct: 403 NESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQ 462
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
+ V E+V + +++RVQA D D+G NA + Y++ +GNV + SG +
Sbjct: 463 NYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI----LSGNVAGQFYLHSLSGILDV 518
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPR-SATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
LD E KY L + A DGG PP +++ F+ ++ + E+
Sbjct: 519 INPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENV 578
Query: 380 PPGTPVVTLTATDAD--EDNRLHYEIT-------GGNTRG--------RFSITSQNGRGL 422
P G PVV + A DAD E+ RLHY + GG + G F N G
Sbjct: 579 PLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGW 638
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
ITV LD ++ Y V A D G S + V I + D N+ PVF Y + E
Sbjct: 639 ITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNE 698
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
DA +G++VL + A D D N+ ITY L+ + A Q+ G IT LD
Sbjct: 699 DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQR-----GGGLITLALPLD 751
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
+ Y+L VTA DG + S T V I+V D N + PVF+ YT ++ ED VGTS+
Sbjct: 752 YKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSI 808
Query: 601 SQVGATDADVGLNGRIHYEL-DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+ + A D D G N RI Y + DP + F IDP SG + T LD E+ + L +A
Sbjct: 809 ATLSANDEDTGENARITYVIQDPVPQ----FRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G P +S T + I I D ND+ P F D I E++P T+I ++ A D D GPN
Sbjct: 865 QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
Query: 720 AVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASP-PLWND 777
+ Y+ +GGDD + F +E G + + +D + + + L + SP PL
Sbjct: 925 GRLLYTFQGGDDGDGDFYIEPTSGVIRTQ--RRLDRENVAVYNLWALAVDRGSPTPLSAS 982
Query: 778 VRVEILVTDVNDNAPVM-KDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILS 833
V +++ + D+NDNAP+ KD +F ++ PVG ++ A D D ++ Y+I+
Sbjct: 983 VEIQVTILDINDNAPMFEKDELELF--VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE 1040
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVT 870
G+ + L+ G + +L+ V + + V T
Sbjct: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT 1077
Score = 310 bits (761), Expect = 5e-83
Identities = 246/776 (31%), Positives = 379/776 (48%), Gaps = 78/776 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND+ P F Q Y V E T VL ++ATD+D G+NA + Y+I
Sbjct: 447 IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI-------- 498
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V F + SG L LD E V +Y++ +KA D P +
Sbjct: 499 -----------LSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP--PLI 545
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+ + V ++D NDN P F + +V E++ + PV+ I+A DAD G N+ + Y
Sbjct: 546 NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPL-GYPVV-HIQAVDADSGENARLHYR 603
Query: 191 II-------GGNT----------QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGG 233
++ GG + F I + SG +++ LD E+V Y + A D G
Sbjct: 604 LVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG 663
Query: 234 SPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELT 293
SP S++T + I + DVNDN P F ++ ++E+ +G S++ +QA D D N+ +T
Sbjct: 664 SPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVIT 721
Query: 294 YTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXX 353
Y +T + T N ++ G + + LD + + +Y L VTA+DG RS TA
Sbjct: 722 YQLTGGN-TRN-RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVL 776
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR 411
F Y V ++ED P GT + TL+A D D E+ R+ Y I + +
Sbjct: 777 INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQ 834
Query: 412 FSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF 469
F I +G + T+ + LD++ + Y LT+ A D+G +SDT ++I I DAN+ AP F
Sbjct: 835 FRIDPDSGT-MYTMME-LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
Y S+FEDAP T++L VSATD D G N ++ Y+ D F I P
Sbjct: 893 LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDG------DGDFYIEPT 946
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTA 588
+G I T + LDRE ++ Y L A D G P+ LS + +++++++D+NDN P+F++
Sbjct: 947 SGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
+ E+ VG+ V+++ A D D G N +I Y++ D F +D +G +R LD E
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRH-FFQLDLLNGDLRAMVELDFE 1065
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF--YISENS---PIG 703
+ + + + P S VHI + D ND+PPV + F Y++ S P G
Sbjct: 1066 VRREY---VLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
IG I AHDPD + ++Y+ G++ L+ G EL DLD P
Sbjct: 1123 -VIGCIPAHDPDVSDS--LNYTFVQGNELRLLLLDPATG----ELQLSRDLDNNRP 1171
Score = 289 bits (708), Expect = 1e-76
Identities = 219/683 (32%), Positives = 332/683 (48%), Gaps = 46/683 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ P+F ++A+V E G V+ ++A D D G+NA + Y + + L
Sbjct: 553 VQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
A F+I SG + A LDRE+V Y+ V+A D SP +
Sbjct: 613 GGGSAGPKNPAPTPDFP--FQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP---PM 667
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SS+ ++ + ++D NDN P F++ TY + ++ED +V + + ++A D D ANS I Y
Sbjct: 668 SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSS--VLTLQARDRD--ANSVITYQ 723
Query: 191 IIGGNTQMQFSIDSLSGD--VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
+ GGNT+ +F++ S G ++L LDY+Q + Y L + A DG +RS+T +LIN+
Sbjct: 724 LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVT 780
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D N + P F +S + SVSE+ P+G SI + A D D G NA +TY + D +P
Sbjct: 781 DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD-------PVP 833
Query: 309 -ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
IDP SG +YT +LD E Q Y L + A D G P +S T T F+
Sbjct: 834 QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNT-RGRFSITSQNGRGLIT 424
Y+ + ED PP T ++ ++ATD D + RL Y GG+ G F I + G+I
Sbjct: 894 WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS--GVIR 951
Query: 425 VAQPLDFKQERRYVLTVSATDSGG---RSDTAMVQINITDANNYAPVFENAPYTASVFED 481
+ LD + Y L A D G S + +Q+ I D N+ AP+FE V E+
Sbjct: 952 TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEEN 1011
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
P+G+ V + A D D G NAQI Y +I + H Q ++N A+ LD
Sbjct: 1012 NPVGSVVAKIRANDPDEGPNAQIMY----QIVEGDMRHFFQLDLLNGDLRAMVE---LDF 1064
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ-QLYTANIMEDALVGTSV 600
E Y+L V A P +S T V I +VD NDN PV Q+ N + +
Sbjct: 1065 EVRREYVLVVQAT--SAPLVSRAT-VHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121
Query: 601 SQVGATDA-DVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+G A D ++ ++Y + E ++DPA+G ++ ++ LD L V+
Sbjct: 1122 GVIGCIPAHDPDVSDSLNYTF-VQGNELRLLLLDPATGELQLSRDLDNNR-PLEALMEVS 1179
Query: 660 IDGGTPPQSSTVIVHIKIEDIND 682
+ G S T +++ I D
Sbjct: 1180 VSDGI--HSVTAFCTLRVTIITD 1200
Score = 177 bits (430), Expect = 6e-43
Identities = 139/457 (30%), Positives = 208/457 (45%), Gaps = 38/457 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H INV D N H PVF+ Y SV E GT++ TL A D+D G+NA + Y I+
Sbjct: 774 HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ---- 829
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
D + P+ FRID SG + T LD E YT+ + A D P
Sbjct: 830 DPV-PQ----------------FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-- 870
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
+ S T T+ + I+D NDN PQF Y S+ ED + + I ++ ATD D G N +
Sbjct: 871 -QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTS--ILQVSATDRDSGPNGRL 927
Query: 188 RYAIIGGNT-QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS-RSNTTQLLI 245
Y GG+ F I+ SG + + LD E V Y L A D GSP+ S + ++ +
Sbjct: 928 LYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQV 987
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D+NDNAP F + V EN P+G + +++A D DEG NA++ Y + + G++
Sbjct: 988 TILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE----GDM 1043
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+D +G + +LD E + +Y L+V AT R+
Sbjct: 1044 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPD 1103
Query: 366 F--MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLI 423
F + Y + P G + + A D D + L+Y GN + G +
Sbjct: 1104 FQILFNNYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGE--L 1160
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT 460
+++ LD + ++ VS +D G S TA + +T
Sbjct: 1161 QLSRDLDNNRPLEALMEVSVSD-GIHSVTAFCTLRVT 1196
Score = 112 bits (270), Expect = 2e-23
Identities = 91/301 (30%), Positives = 136/301 (45%), Gaps = 15/301 (4%)
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDP--KDREEGSFVIDPASGV 638
F Y + E+ GT + Q+ A G R+ Y ++ +R G F ID A+G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 639 IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISE 698
+ T+ LDRE+ TH L+ A+D TPP+S+T + + ++D ND PVFE + E
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
Query: 699 NSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES 758
N +G + IRA D D NA + Y + GG + F L G + T LD E
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSG----VVSTRAVLDREE 419
Query: 759 PRKKYELVIRA----ASP-PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF 813
+Y+L++ A +P PL V I V D NDN P + + +D
Sbjct: 420 -AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
Query: 814 GRVPAYDADVTDK--LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
RV A D D + Y ILSGN A L+ +G + + L+ + ++ + D
Sbjct: 479 LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
Query: 872 G 872
G
Sbjct: 539 G 539
Score = 68.5 bits (160), Expect = 3e-10
Identities = 47/151 (31%), Positives = 78/151 (51%), Gaps = 14/151 (9%)
Query: 2173 GIRLKKPIRLQIWLDINRETFGSRTNPQCVHWS---TLRGSGEWSRVGCHTEIDYDWSPY 2229
G L +P+ + ++ RT P CV W+ + G+G WS GC
Sbjct: 2383 GAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCEL--------L 2434
Query: 2230 SEEPLLINCTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCL 2289
S + C C+H ++FAVL+D + E L+ VT Y A S+SL LL ++ L L
Sbjct: 2435 SRNRTHVACQCSHTASFAVLMD-ISRRENGEVLPLKIVT-YAAVSLSLAALLVAFVLLSL 2492
Query: 2290 IRGGAATVSNSIHKHLIFSVFMAELLYLIAL 2320
+R + + +SIHKHL ++F+++L+++I +
Sbjct: 2493 VRMLRSNL-HSIHKHLAVALFLSQLVFVIGI 2522
>AF231024-1|AAF61930.1| 3014|Homo sapiens protocadherin Flamingo 2
protein.
Length = 3014
Score = 922 bits (2281), Expect = 0.0
Identities = 494/1116 (44%), Positives = 688/1116 (61%), Gaps = 73/1116 (6%)
Query: 13 VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNP 72
V D NDHSPVFE +Y VRE G VLT++A+D+D NA + Y +
Sbjct: 343 VKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRV---------- 392
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSS 132
DVF+++ SG + TRA LDRE+ A Y +LV+A DQ LS+
Sbjct: 393 ----------LGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGP-LSA 441
Query: 133 TATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII 192
TAT+++ + D+NDNYPQFSE+ Y V V ED+ + N + +++ATD D G N+AI Y+I+
Sbjct: 442 TATVYIEVEDENDNYPQFSEQNYVVQVPEDVGL--NTAVLRVQATDRDQGQNAAIHYSIL 499
Query: 193 GGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRDVN 251
GN QF + SLSG + ++ LD+E V+ Y L I+AQDGG P N++ ++ + + DVN
Sbjct: 500 SGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVN 559
Query: 252 DNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD------------- 298
DN P F +S FQ +V ENVP+GY +V +QA DAD G NA L Y + D
Sbjct: 560 DNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGP 619
Query: 299 KDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
K+ D P I SGW+ +LDRE Y V A D G PP S++ +
Sbjct: 620 KNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLD 679
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN 418
F YE+ L ED G+ V+TL A D D ++ + Y++TGGNTR RF+++SQ
Sbjct: 680 VNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQR 739
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASV 478
G GLIT+A PLD+KQE++YVL V+A+D G RS TA V IN+TDAN + PVF+++ YT SV
Sbjct: 740 GGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQSSHYTVSV 798
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED P+GT++ +SA D D G NA+ITY + + QF I+P +G + T
Sbjct: 799 SEDRPVGTSIATLSANDEDTGENARITYVIQDPVP---------QFRIDPDSGTMYTMME 849
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LD E Y LT+ A+D G+P SDTT +EI ++D NDN P F Y +I EDA T
Sbjct: 850 LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPST 909
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAV 658
S+ QV ATD D G NGR+ Y D +G F I+P SGVIRT + LDRE+VA ++L A+
Sbjct: 910 SILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWAL 969
Query: 659 AIDGGTP-PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A+D G+P P S++V + + I DIND+ P+FE D L ++ EN+P+G+ + +IRA+DPDEG
Sbjct: 970 AVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
PNA + Y I GD + F L+ G +L MV+LD+E R++Y LV++A S PL +
Sbjct: 1030 PNAQIMYQIVEGDMRHFFQLDLLNG----DLRAMVELDFEV-RREYVLVVQATSAPLVSR 1084
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILS 833
V IL+ D NDN PV+ DFQI+FNNY + FP G G +PA+D DV+D L Y +
Sbjct: 1085 ATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQ 1144
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLL 893
GN L+LL+ TG + LS L+ N P A MEVSV+DG++ + A L V +IT++ML
Sbjct: 1145 GNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLT 1204
Query: 894 NSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSA 953
NSITVRL +M+ E+FLSPLL F++G+AA++ K+++++F+VQ+DTDV+ NILNV+FSA
Sbjct: 1205 NSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSA 1264
Query: 954 RRPDAEVGVAGDPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEEC 1013
P GV G + L+E++YL+RT L ++T +VLPFDDNIC+ EPC N+ +C
Sbjct: 1265 LLPG---GVRGQ---FFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKC 1318
Query: 1014 LTVLKFGNASGFVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSIC 1073
++VL+F +++ F++S +VLFRPI+P+ C+CP GFTG CET + + G C
Sbjct: 1319 VSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRC 1378
Query: 1074 RSGSQCVARREGGILCQGCSIDAAYTTAVCELRARS 1109
RS REGG C+ C D +T CE+ ARS
Sbjct: 1379 RS-------REGGYTCE-CFED--FTGEHCEVDARS 1404
Score = 591 bits (1460), Expect = e-167
Identities = 319/903 (35%), Positives = 479/903 (53%), Gaps = 84/903 (9%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC+C E FTG +CE C +C++G CV GG C C Y
Sbjct: 1385 YTCECFEDFTGEHCEVDARSGRCA----NGVCKNGGTCVNLLIGGFHCV-CP-PGEYERP 1438
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
CE+ RSFP SF+TF GL++R + L FATQ +GLLLYNGR+NE+HDF+ALE+V
Sbjct: 1439 YCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVD 1498
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEIT--VEGNVGDGSWHTVEIEYFNRT------------ 1207
+ ++ +FS G + + V V DG WH+V+++Y+N+
Sbjct: 1499 EQ--------VQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPS 1550
Query: 1208 ----ITMILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTET-CHRFLDLTGPL 1262
+ +DDCD +++ D G Y+CA T+T + LDLTGPL
Sbjct: 1551 GEKMAVVTVDDCDTTMAVRFGKDIG-NYSCA-----------AQGTQTGSKKSLDLTGPL 1598
Query: 1263 QIGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPC 1322
+GG+PN+P F V N+ FVGC+ + +D K +D+ ++A+NGT GC +R+ C C
Sbjct: 1599 LLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRC 1658
Query: 1323 YNGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFNPLLRPIQLPWLNALS 1382
NG C + W+ Y+C+C GK+C + P F G+ ++S++ L I +PW L
Sbjct: 1659 QNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLM 1718
Query: 1383 IRTRQRDAFVMS----------IQLKSGLLHYSYNG-----ETMYLPMATLSDGAWHR-- 1425
RTR+ D+ +M +Q+ + L + + E++ L ++DG WH
Sbjct: 1719 FRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLL 1778
Query: 1426 IEIKWLGTD------ISVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDV 1479
IE+K + D +++T+DYG+ + + G + +++GG +
Sbjct: 1779 IELKNVKEDSEMKHLVTMTLDYGMDQNKAD-IGGMLPGLTVRSVVVGGASEDKVSVRRG- 1836
Query: 1480 GFFEGCIQDVRIG---TAQSLLN-RPTVRENVRDGCQSRADCMLSICPPYSKCVTSWDSS 1535
F GC+Q VR+G T + LN ++ V+DGC C S CPP S+C +W+
Sbjct: 1837 --FRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDY 1894
Query: 1536 TCTCEAGRVGPQCVSACELGPC-GAARCVPDQ-TPKGYSCACEPGYTLTTSGCIESGKEE 1593
+C C+ G +G CV AC L PC CV +P+GY C C P + C
Sbjct: 1895 SCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHY--GPYCENKLDLP 1952
Query: 1594 CPGGWWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSEN 1653
CP GWWG CGPC C V++G+ P CNK NG+C CKEN+YK CLPC C+ GS +
Sbjct: 1953 CPRGWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHS 2012
Query: 1654 SSCEAATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFG 1713
+C+ ATGQC C+PGVIGR C+ C N +AEVT GCEV+Y+GCP++F G+WWP+TKFG
Sbjct: 2013 RTCDMATGQCACKPGVIGRQCNRCDNPFAEVT-TLGCEVIYNGCPKAFEAGIWWPQTKFG 2071
Query: 1714 VETITDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTF 1773
CP GS G A R C K W P++FNCTT +F LR K+ E ++
Sbjct: 2072 QPAAVPCPKGSVGNAVRHCSGEKG--WLPPELFNCTTISFVDLRAMNEKLSRNETQVDGA 2129
Query: 1774 VGVRVAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLK 1833
+++ L +A +T L+G DV A +L ++ +E Q G +L +QD D+ +++
Sbjct: 2130 RALQLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIH 2189
Query: 1834 STNTILNVEYEREWKRIRELTGHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKDVVI 1893
S + +L W++I+ G A+LL ++ + Y + +A + TY PF IVT ++++
Sbjct: 2190 SGSALLAPATRAAWEQIQRSEGGTAQLL-RRLEGYFSNVARNVRRTYLRPFVIVTANMIL 2248
Query: 1894 SVD 1896
+VD
Sbjct: 2249 AVD 2251
Score = 348 bits (856), Expect = 1e-94
Identities = 278/877 (31%), Positives = 418/877 (47%), Gaps = 73/877 (8%)
Query: 23 FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAXXXXXXX 82
F M Y+ ++ E +GT +L L A G+ V Y +E L E +
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYME-----GLFDERS------- 292
Query: 83 XXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIID 142
+ FRID +GA+ T + LDRE + + VKA D ++P S+T I V + D
Sbjct: 293 ----RGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPR---SATTYITVLVKD 345
Query: 143 DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI 202
ND+ P F + Y V E++ V + I+A+D D N+ +RY ++GG + F +
Sbjct: 346 TNDHSPVFEQSEYRERVRENLEV--GYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQL 402
Query: 203 DSLSGDVSLVKTLDYEQVRSYRLVIRAQD-GGSPS-RSNTTQLLINIRDVNDNAPRFYTS 260
+ SG VS LD E+ Y+L++ A D G +P S T + I + D NDN P+F
Sbjct: 403 NESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQ 462
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
+ V E+V + +++RVQA D D+G NA + Y++ +GNV + SG +
Sbjct: 463 NYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI----LSGNVAGQFYLHSLSGILDV 518
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPR-SATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
LD E KY L + A DGG PP +++ F+ ++ + E+
Sbjct: 519 INPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENV 578
Query: 380 PPGTPVVTLTATDAD--EDNRLHYEIT-------GGNTRG--------RFSITSQNGRGL 422
P G PVV + A DAD E+ RLHY + GG + G F N G
Sbjct: 579 PLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGW 638
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
ITV LD ++ Y V A D G S + V I + D N+ PVF Y + E
Sbjct: 639 ITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNE 698
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
DA +G++VL + A D D N+ ITY L+ + A Q+ G IT LD
Sbjct: 699 DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQR-----GGGLITLALPLD 751
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
+ Y+L VTA DG + S T V I+V D N + PVF+ YT ++ ED VGTS+
Sbjct: 752 YKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSI 808
Query: 601 SQVGATDADVGLNGRIHYEL-DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+ + A D D G N RI Y + DP + F IDP SG + T LD E+ + L +A
Sbjct: 809 ATLSANDEDTGENARITYVIQDPVPQ----FRIDPDSGTMYTMMELDYENQVAYTLTIMA 864
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G P +S T + I I D ND+ P F D I E++P T+I ++ A D D GPN
Sbjct: 865 QDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPN 924
Query: 720 AVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASP-PLWND 777
+ Y+ +GGDD + F +E G + + +D + + + L + SP PL
Sbjct: 925 GRLLYTFQGGDDGDGDFYIEPTSGVIRTQ--RRLDRENVAVYNLWALAVDRGSPTPLSAS 982
Query: 778 VRVEILVTDVNDNAPVM-KDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILS 833
V +++ + D+NDNAP+ KD +F ++ PVG ++ A D D ++ Y+I+
Sbjct: 983 VEIQVTILDINDNAPMFEKDELELF--VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE 1040
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVT 870
G+ + L+ G + +L+ V + + V T
Sbjct: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT 1077
Score = 310 bits (761), Expect = 5e-83
Identities = 246/776 (31%), Positives = 379/776 (48%), Gaps = 78/776 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND+ P F Q Y V E T VL ++ATD+D G+NA + Y+I
Sbjct: 447 IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSI-------- 498
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V F + SG L LD E V +Y++ +KA D P +
Sbjct: 499 -----------LSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP--PLI 545
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+ + V ++D NDN P F + +V E++ + PV+ I+A DAD G N+ + Y
Sbjct: 546 NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPL-GYPVV-HIQAVDADSGENARLHYR 603
Query: 191 II-------GGNT----------QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGG 233
++ GG + F I + SG +++ LD E+V Y + A D G
Sbjct: 604 LVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG 663
Query: 234 SPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELT 293
SP S++T + I + DVNDN P F ++ ++E+ +G S++ +QA D D N+ +T
Sbjct: 664 SPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVIT 721
Query: 294 YTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXX 353
Y +T + T N ++ G + + LD + + +Y L VTA+DG RS TA
Sbjct: 722 YQLTGGN-TRN-RFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVL 776
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR 411
F Y V ++ED P GT + TL+A D D E+ R+ Y I + +
Sbjct: 777 INVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQ 834
Query: 412 FSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF 469
F I +G + T+ + LD++ + Y LT+ A D+G +SDT ++I I DAN+ AP F
Sbjct: 835 FRIDPDSGT-MYTMME-LDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQF 892
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
Y S+FEDAP T++L VSATD D G N ++ Y+ D F I P
Sbjct: 893 LWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDG------DGDFYIEPT 946
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTA 588
+G I T + LDRE ++ Y L A D G P+ LS + +++++++D+NDN P+F++
Sbjct: 947 SGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL 1006
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
+ E+ VG+ V+++ A D D G N +I Y++ D F +D +G +R LD E
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRH-FFQLDLLNGDLRAMVELDFE 1065
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF--YISENS---PIG 703
+ + + + P S VHI + D ND+PPV + F Y++ S P G
Sbjct: 1066 VRREY---VLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
IG I AHDPD + ++Y+ G++ L+ G EL DLD P
Sbjct: 1123 -VIGCIPAHDPDVSDS--LNYTFVQGNELRLLLLDPATG----ELQLSRDLDNNRP 1171
Score = 289 bits (708), Expect = 1e-76
Identities = 219/683 (32%), Positives = 332/683 (48%), Gaps = 46/683 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ P+F ++A+V E G V+ ++A D D G+NA + Y + + L
Sbjct: 553 VQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
A F+I SG + A LDRE+V Y+ V+A D SP +
Sbjct: 613 GGGSAGPKNPAPTPDFP--FQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSP---PM 667
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SS+ ++ + ++D NDN P F++ TY + ++ED +V + + ++A D D ANS I Y
Sbjct: 668 SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSS--VLTLQARDRD--ANSVITYQ 723
Query: 191 IIGGNTQMQFSIDSLSGD--VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
+ GGNT+ +F++ S G ++L LDY+Q + Y L + A DG +RS+T +LIN+
Sbjct: 724 LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVT 780
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D N + P F +S + SVSE+ P+G SI + A D D G NA +TY + D +P
Sbjct: 781 DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQD-------PVP 833
Query: 309 -ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
IDP SG +YT +LD E Q Y L + A D G P +S T T F+
Sbjct: 834 QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNT-RGRFSITSQNGRGLIT 424
Y+ + ED PP T ++ ++ATD D + RL Y GG+ G F I + G+I
Sbjct: 894 WDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS--GVIR 951
Query: 425 VAQPLDFKQERRYVLTVSATDSGG---RSDTAMVQINITDANNYAPVFENAPYTASVFED 481
+ LD + Y L A D G S + +Q+ I D N+ AP+FE V E+
Sbjct: 952 TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEEN 1011
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
P+G+ V + A D D G NAQI Y +I + H Q ++N A+ LD
Sbjct: 1012 NPVGSVVAKIRANDPDEGPNAQIMY----QIVEGDMRHFFQLDLLNGDLRAMVE---LDF 1064
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ-QLYTANIMEDALVGTSV 600
E Y+L V A P +S T V I +VD NDN PV Q+ N + +
Sbjct: 1065 EVRREYVLVVQAT--SAPLVSRAT-VHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121
Query: 601 SQVGATDA-DVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+G A D ++ ++Y + E ++DPA+G ++ ++ LD L V+
Sbjct: 1122 GVIGCIPAHDPDVSDSLNYTF-VQGNELRLLLLDPATGELQLSRDLDNNR-PLEALMEVS 1179
Query: 660 IDGGTPPQSSTVIVHIKIEDIND 682
+ G S T +++ I D
Sbjct: 1180 VSDGI--HSVTAFCTLRVTIITD 1200
Score = 177 bits (430), Expect = 6e-43
Identities = 139/457 (30%), Positives = 208/457 (45%), Gaps = 38/457 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H INV D N H PVF+ Y SV E GT++ TL A D+D G+NA + Y I+
Sbjct: 774 HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ---- 829
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
D + P+ FRID SG + T LD E YT+ + A D P
Sbjct: 830 DPV-PQ----------------FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-- 870
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
+ S T T+ + I+D NDN PQF Y S+ ED + + I ++ ATD D G N +
Sbjct: 871 -QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTS--ILQVSATDRDSGPNGRL 927
Query: 188 RYAIIGGNT-QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS-RSNTTQLLI 245
Y GG+ F I+ SG + + LD E V Y L A D GSP+ S + ++ +
Sbjct: 928 LYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQV 987
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D+NDNAP F + V EN P+G + +++A D DEG NA++ Y + + G++
Sbjct: 988 TILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE----GDM 1043
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+D +G + +LD E + +Y L+V AT R+
Sbjct: 1044 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPD 1103
Query: 366 F--MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLI 423
F + Y + P G + + A D D + L+Y GN + G +
Sbjct: 1104 FQILFNNYVTNKSNSFPTGV-IGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGE--L 1160
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT 460
+++ LD + ++ VS +D G S TA + +T
Sbjct: 1161 QLSRDLDNNRPLEALMEVSVSD-GIHSVTAFCTLRVT 1196
Score = 112 bits (270), Expect = 2e-23
Identities = 91/301 (30%), Positives = 136/301 (45%), Gaps = 15/301 (4%)
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDP--KDREEGSFVIDPASGV 638
F Y + E+ GT + Q+ A G R+ Y ++ +R G F ID A+G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 639 IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISE 698
+ T+ LDRE+ TH L+ A+D TPP+S+T + + ++D ND PVFE + E
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
Query: 699 NSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES 758
N +G + IRA D D NA + Y + GG + F L G + T LD E
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSG----VVSTRAVLDREE 419
Query: 759 PRKKYELVIRA----ASP-PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF 813
+Y+L++ A +P PL V I V D NDN P + + +D
Sbjct: 420 -AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
Query: 814 GRVPAYDADVTDK--LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
RV A D D + Y ILSGN A L+ +G + + L+ + ++ + D
Sbjct: 479 LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
Query: 872 G 872
G
Sbjct: 539 G 539
Score = 68.5 bits (160), Expect = 3e-10
Identities = 47/151 (31%), Positives = 78/151 (51%), Gaps = 14/151 (9%)
Query: 2173 GIRLKKPIRLQIWLDINRETFGSRTNPQCVHWS---TLRGSGEWSRVGCHTEIDYDWSPY 2229
G L +P+ + ++ RT P CV W+ + G+G WS GC
Sbjct: 2383 GAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCEL--------L 2434
Query: 2230 SEEPLLINCTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCL 2289
S + C C+H ++FAVL+D + E L+ VT Y A S+SL LL ++ L L
Sbjct: 2435 SRNRTHVACQCSHTASFAVLMD-ISRRENGEVLPLKIVT-YAAVSLSLAALLVAFVLLSL 2492
Query: 2290 IRGGAATVSNSIHKHLIFSVFMAELLYLIAL 2320
+R + + +SIHKHL ++F+++L+++I +
Sbjct: 2493 VRMLRSNL-HSIHKHLAVALFLSQLVFVIGI 2522
>AY714129-1|AAU94938.1| 4186|Homo sapiens anchor protein protein.
Length = 4186
Score = 903 bits (2234), Expect = 0.0
Identities = 477/1085 (43%), Positives = 665/1085 (61%), Gaps = 52/1085 (4%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ V D NDHSPVFE QY ++RE G +L L+ATD D NA + Y +
Sbjct: 491 VTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRF-------V 543
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P A F ID RSG + T +DRE + Y ++V+A+DQ R
Sbjct: 544 GPPAARAAAAAA-------FEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPR- 595
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+T +H+ ++D+NDN PQFSEK Y V ED V + V+ ++ ATD D AN + Y
Sbjct: 596 SATVRVHITVLDENDNAPQFSEKRYVAQVRED--VRPHTVVLRVTATDRDKDANGLVHYN 653
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRD 249
II GN++ F+IDSL+G++ +V LD+E R Y L IRAQD G P SN T L I + D
Sbjct: 654 IISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVD 713
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
+ND+ P F ++ FQ SV EN P+G+S++ +QA DAD G NA L Y++T D P
Sbjct: 714 INDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVA----PDTPF 769
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
I+ +GWV SG LDRE+ Y V A D G PP SA+A+ F
Sbjct: 770 VINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMK 829
Query: 370 QYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPL 429
+Y + L ED GT VV++TA D D ++ + Y+ITGGNTR RF+I++Q G GL+T+A PL
Sbjct: 830 EYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPL 889
Query: 430 DFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
D+KQER + L ++A+D D V INITDAN + PVF++A Y+ SV ED P+G+T++
Sbjct: 890 DYKQERYFKLVLTASDRA-LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIV 948
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
V+SA+D DVG NA+ITY L + QF I+ +GAIT LD E Y L
Sbjct: 949 VISASDDDVGENARITYLLEDNLP---------QFRIDADSGAITLQAPLDYEDQVTYTL 999
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
+TARD G+P +DTT VE+ V DVNDN P F YT + EDA TSV Q+ ATD D
Sbjct: 1000 AITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRD 1059
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
NGR+ Y + +G F I+P SG++RT + LDRE+V+ ++L A A+D G PP +
Sbjct: 1060 AHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRT 1119
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
V + + ++D+ND+ PVF ++ + ENS +G+ + +I A DPDEGPNA + Y I G
Sbjct: 1120 PVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEG 1179
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVND 789
+ F ++ G EL ++DLDYE+ R++Y +V++A S PL + V + + D ND
Sbjct: 1180 NIPELFQMDIFSG----ELTALIDLDYEA-RQEYVIVVQATSAPLVSRATVHVRLVDQND 1234
Query: 790 NAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNET 845
N+PV+ +FQI+FNNY D FP G GR+PAYD DV+D L Y GN L+++N+T
Sbjct: 1235 NSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQT 1294
Query: 846 TGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTA 905
+G + LS +L+ N P +A+M V+VTDG++ + A L V +ITEE+L NS+TVRL +M
Sbjct: 1295 SGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVIITEELLANSLTVRLENMWQ 1354
Query: 906 EQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSARRP-DAEVGVAG 964
E+FLSPLLG F++G+AA++ P E+++IF++Q+DTDV G +LNVSFSA P A G AG
Sbjct: 1355 ERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDVGGTVLNVSFSALAPRGAGAGAAG 1414
Query: 965 DPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEECLTVLKFGNASG 1024
P +S L+E++Y+ R LA + + VLPFDDN+C+ EPC N+ +C++VL+F +++
Sbjct: 1415 ---PWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCLREPCENYMKCVSVLRFDSSAP 1471
Query: 1025 FVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARRE 1084
F+ S S LFRPI P+ C+CP GFTG CET L + CR+G C ARRE
Sbjct: 1472 FLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCY------SNPCRNGGAC-ARRE 1524
Query: 1085 GGILC 1089
GG C
Sbjct: 1525 GGYTC 1529
Score = 628 bits (1551), Expect = e-179
Identities = 348/912 (38%), Positives = 488/912 (53%), Gaps = 84/912 (9%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC C FTG +CE C V G +CR+G C GG CQ C A+
Sbjct: 1527 YTCVCRPRFTGEDCELDTEAGRC-VPG---VCRNGGTCTDAPNGGFRCQ-CPAGGAFEGP 1581
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
CE+ ARSFP SSF+ F GL++R + L L FAT SGLL YNGR NE+HDFLALELV+
Sbjct: 1582 RCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVA 1641
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEI--TVEGNVGDGSWHTVEIEYFNRTIT---------- 1209
+ +R ++S G + + TV G + DG WHTV + Y+N+ T
Sbjct: 1642 GQ--------VRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPS 1693
Query: 1210 ------MILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTETCHRFLDLTGPLQ 1263
+ +DDCD ++L A+ G Y+C A + T + + LDLTGPL
Sbjct: 1694 KDKVAVLSVDDCDVAVALQFGAEIG-NYSC---------AAAGVQTSS-KKSLDLTGPLL 1742
Query: 1264 IGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPCY 1323
+GG+PN+P +F V +KDF+GC+ D +ID + +D+ ++VA+NGT+AGC K C S PC
Sbjct: 1743 LGGVPNLPENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCK 1802
Query: 1324 NGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFN-PLLRPIQLPWLNALS 1382
N CS+ W ++ CDC G GKDC + P F G+G LS+N + +PW L+
Sbjct: 1803 NSGFCSERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLA 1862
Query: 1383 IRTRQRDAFVMSI----------QLKSGLLHY-----SYNGETMYLPMATLSDGAWH--R 1425
RTR +M + QL GLL S + L T+SDG WH R
Sbjct: 1863 FRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLR 1922
Query: 1426 IEIK-----WLGTDI-SVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDV 1479
+E++ G + V++D+ L M + +++QG + ++ +GGL + A
Sbjct: 1923 LELQEEPGGRRGHHVLMVSLDFSLFQDTM-AVGSELQGLKVKQLHVGGLPPGSAEEAPQ- 1980
Query: 1480 GFFEGCIQDVRIGTAQS---LLNRPTVRENVRDGCQSRADCMLSICPPYSKCVTSWDSST 1536
G GCIQ V +G+ S L P+ R N GC C CPP++ C W + +
Sbjct: 1981 GLV-GCIQGVWLGSTPSGSPALLPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFS 2039
Query: 1537 CTCEAGRVGPQCVSACELGPC---GAARCVPDQTPKGYSCACEPGYTLTTSGCIESGKEE 1593
CTC+ G GP CV AC L PC G+ R +P P GY+C C GY C ++
Sbjct: 2040 CTCQPGYYGPGCVDACLLNPCQNQGSCRHLPG-APHGYTCDCVGGY--FGHHCEHRMDQQ 2096
Query: 1594 CPGGWWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSEN 1653
CP GWWG CGPC CDV +G+ P+CNK NG+CHCKE HY+P G+ CLPC CY GS +
Sbjct: 2097 CPRGWWGSPTCGPCNCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTS 2156
Query: 1654 SSCEAATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFG 1713
SC +GQC CRPG +GR C++C + +AEVT SGC V+YD CP+S GVWWP+TKFG
Sbjct: 2157 RSCAPHSGQCPCRPGALGRQCNSCDSPFAEVTA-SGCRVLYDACPKSLRSGVWWPQTKFG 2215
Query: 1714 VETITDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTF 1773
V CP G+ G A R CDE + W +PD+FNCT+ F +L L +E + ++T
Sbjct: 2216 VLATVPCPRGALGAAVRLCDEAQG--WLEPDLFNCTSPAFRELSLLLDGLELNKTALDTM 2273
Query: 1774 VGVRVAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLK 1833
++A L +T + DV V +L L+ +E Q G LT +QD + NLL
Sbjct: 2274 EAKKLAQRLREVTGHTDHYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLW 2333
Query: 1834 STNTILNVEYEREWKRIRELT---GHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKD 1890
+ + +L E W + + G+ LV+ +EY A LA + TY +P +VT +
Sbjct: 2334 AGSALLAPETGDLWAALGQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPN 2393
Query: 1891 VVISVDTVTSES 1902
+++S+D + S
Sbjct: 2394 IMLSIDRMEHPS 2405
Score = 355 bits (872), Expect = 2e-96
Identities = 255/807 (31%), Positives = 390/807 (48%), Gaps = 42/807 (5%)
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY---AIIGGNTQMQFS 201
+ +PQF + Y V E+ + + ++ A D D G + Y A++ + FS
Sbjct: 390 NRHPQFPQYNYQTLVPENEAA--GTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 447
Query: 202 IDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
ID SG + LD E + + L + AQD GSP S TT + + + D ND++P F +
Sbjct: 448 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 507
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT-GNVDLPITIDPRSGWVYT 320
++E++ ENV GY I++++A D D NA L Y IDPRSG + T
Sbjct: 508 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 567
Query: 321 SGQLDRETQAKYQLLVTATD-GGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
SG++DRE Y+L+V A+D G +P PRSAT F +Y ++ ED
Sbjct: 568 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 627
Query: 379 EPPGTPVVTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
P T V+ +TATD D+D +HY I GN+RG F+I S G I V PLDF+ ER
Sbjct: 628 VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGE--IQVVAPLDFEAERE 685
Query: 437 YVLTVSATDSGG---RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSA 493
Y L + A D+G ++T + I + D N++ P+F + P+ SV E+AP+G +V+ + A
Sbjct: 686 YALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQA 745
Query: 494 TDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D+D G NA++ YSL+ VA D FVIN TG ++ + LDRE++ Y V A
Sbjct: 746 VDADHGENARLEYSLT------GVA-PDTPFVINSATGWVSVSGPLDRESVEHYFFGVEA 798
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
RD G P LS + V ++V+DVNDN P F + Y + EDA VGTSV V A D D N
Sbjct: 799 RDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--N 856
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
I Y++ F I GV AL + K V + V
Sbjct: 857 SAISYQI-TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLV-LTASDRALHDHCYV 914
Query: 674 HIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSN 733
HI I D N PVF+S + ++E+ P+G+TI I A D D G NA + Y ++ D+
Sbjct: 915 HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLP 972
Query: 734 SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDN 790
F ++ +D + LDYE + Y L I A P + VE++V DVNDN
Sbjct: 973 QFRID----ADSGAITLQAPLDYED-QVTYTLAITARDNGIPQKADTTYVEVMVNDVNDN 1027
Query: 791 APVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNAN-LILLNETTG 847
AP +D P ++ A D D ++QY +G + + + T+G
Sbjct: 1028 APQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSG 1087
Query: 848 SMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTAE 906
+ +L+ + + D GV ++ +S++++ +++ N+ +
Sbjct: 1088 IVRTVRRLDREAVSVYELTAYAVDRGVPPLRT--PVSIQVMVQDVNDNAPVFPAEEFEVR 1145
Query: 907 QFLSPLLGFFIDGLAAIIPCPKENIYI 933
+ ++G + + A+ P N +I
Sbjct: 1146 VKENSIVGSVVAQITAVDPDEGPNAHI 1172
Score = 343 bits (843), Expect = 6e-93
Identities = 272/912 (29%), Positives = 428/912 (46%), Gaps = 69/912 (7%)
Query: 17 NDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAX 76
N H P F Y+ V E ++GT VL + A D D G+ + Y++ A +N
Sbjct: 390 NRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSL----AALMNSRSL- 443
Query: 77 XXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATI 136
++F ID +SG + T A+LDRE + R+ + V A D SP RLS+T +
Sbjct: 444 -----------ELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMV 489
Query: 137 HVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIG--- 193
V + D ND+ P F + Y ++ E +V + I +++ATD D N+ +RY +G
Sbjct: 490 AVTVADRNDHSPVFEQAQYRETLRE--NVEEGYPILQLRATDGDAPPNANLRYRFVGPPA 547
Query: 194 --GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSP--SRSNTTQLLINIRD 249
F ID SG +S +D E + SY LV+ A D G RS T ++ I + D
Sbjct: 548 ARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLD 607
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
NDNAP+F + V E+V ++RV A D D+ N + Y + +GN
Sbjct: 608 ENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNI----ISGNSRGHF 663
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRS-ATATXXXXXXXXXXXXXXFMP 368
ID +G + LD E + +Y L + A D G PP S T F+
Sbjct: 664 AIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS 723
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVA 426
++V + E+ P G V+ + A DAD E+ RL Y +TG F I S G ++V+
Sbjct: 724 TPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINS--ATGWVSVS 781
Query: 427 QPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPI 484
PLD + Y V A D G S +A V + + D N+ P F Y + EDA +
Sbjct: 782 GPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAV 841
Query: 485 GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETM 544
GT+V+ V+A D D N+ I+Y ++ + A Q V G +T LD +
Sbjct: 842 GTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGV-----GLVTLALPLDYKQE 894
Query: 545 SGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVG 604
+ L +TA D +L D V I++ D N + PVF+ Y+ ++ ED +G+++ +
Sbjct: 895 RYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVIS 951
Query: 605 ATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGT 664
A+D DVG N RI Y L+ + F ID SG I LD E T+ L A D G
Sbjct: 952 ASDDDVGENARITYLLEDNLPQ---FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGI 1008
Query: 665 PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHY 724
P ++ T V + + D+ND+ P F + T +SE++P T++ +I A D D N V Y
Sbjct: 1009 PQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY 1068
Query: 725 SIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEIL 783
+ + G+D + F++E G V +D + S + + PPL V ++++
Sbjct: 1069 TFQNGEDGDGDFTIEPTSGI--VRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVM 1126
Query: 784 VTDVNDNAPVM--KDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNAN 838
V DVNDNAPV ++F++ K+ VG ++ A D D + Y+I+ GN
Sbjct: 1127 VQDVNDNAPVFPAEEFEV---RVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPE 1183
Query: 839 LILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITE---EMLLNS 895
L ++ +G +T L+ + + V T + + + VRL+ + +LN+
Sbjct: 1184 LFQMDIFSGELTALIDLDYEARQEYVIVVQATSA--PLVSRATVHVRLVDQNDNSPVLNN 1241
Query: 896 ITVRLNDMTAEQ 907
+ N+ + +
Sbjct: 1242 FQILFNNYVSNR 1253
Score = 309 bits (758), Expect = 1e-82
Identities = 227/734 (30%), Positives = 358/734 (48%), Gaps = 56/734 (7%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
+ I VLD ND++P F ++Y A VRE T VL + ATD+D N V Y I ++
Sbjct: 599 VRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNI--IS 656
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
++ + F ID +G + A LD E Y + ++A D P
Sbjct: 657 GNS-----------------RGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPP 699
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
++T + ++D ND+ P F + VSV E+ + + + I+A DAD G N+
Sbjct: 700 LS--NNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS--VIHIQAVDADHGENAR 755
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ Y++ G F I+S +G VS+ LD E V Y + A+D GSP S + + +
Sbjct: 756 LEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVT 815
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDN P F + ++E+ +G S+V V A D D N+ ++Y +T + T N
Sbjct: 816 VLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGN-TRN-R 871
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I+ G V + LD + + ++L++TA+D F
Sbjct: 872 FAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVF 928
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
Y V + ED P G+ +V ++A+D D E+ R+ Y + + R S G IT
Sbjct: 929 QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADS----GAIT 984
Query: 425 VAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+ PLD++ + Y L ++A D+G ++DT V++ + D N+ AP F + YT V EDA
Sbjct: 985 LQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDA 1044
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
P T+VL +SATD D N ++ Y+ + D F I P +G + T + LDRE
Sbjct: 1045 PPFTSVLQISATDRDAHANGRVQYTFQNGEDG------DGDFTIEPTSGIVRTVRRLDRE 1098
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
+S Y LT A D GVP L +++ V DVNDN PVF + + + E+++VG+ V+Q
Sbjct: 1099 AVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQ 1158
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDG 662
+ A D D G N I Y++ + E F +D SG + LD E+ + + +
Sbjct: 1159 ITAVDPDEGPNAHIMYQIVEGNIPE-LFQMDIFSGELTALIDLDYEARQEY---VIVVQA 1214
Query: 663 GTPPQSSTVIVHIKIEDINDSPPVFESDCLTF--YISENS---PIGTTIGEIRAHDPDEG 717
+ P S VH+++ D ND+ PV + + F Y+S S P G IG I A+DPD
Sbjct: 1215 TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVS 1273
Query: 718 PNAVVHYSIKGGDD 731
+ + YS + G++
Sbjct: 1274 DH--LFYSFERGNE 1285
Score = 271 bits (665), Expect = 2e-71
Identities = 202/648 (31%), Positives = 310/648 (47%), Gaps = 28/648 (4%)
Query: 236 SRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT 295
+R T+ R + P+F +Q V EN G +++RV A D D G L Y+
Sbjct: 374 ARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYS 433
Query: 296 MTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXX 355
+ + +++L +IDP+SG + T+ LDRE+ ++ L VTA D G P SAT
Sbjct: 434 LAALMNSRSLEL-FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVT 492
Query: 356 XXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITG---GNTRG 410
F QY L E+ G P++ L ATD D + L Y G
Sbjct: 493 VADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAA 552
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS----GGRSDTAMVQINITDANNYA 466
+ GLI+ + +D + Y L V A+D G RS T V I + D N+ A
Sbjct: 553 AAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA 612
Query: 467 PVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
P F Y A V ED T VL V+ATD D N + Y++ IS + H F I
Sbjct: 613 PQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNI---ISGNSRGH----FAI 665
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV-EISVVDVNDNEPVFKQQL 585
+ TG I LD E Y L + A+D G P LS+ T + I VVD+ND+ P+F
Sbjct: 666 DSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTP 725
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKAL 645
+ +++E+A +G SV + A DAD G N R+ Y L + FVI+ A+G + + L
Sbjct: 726 FQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGV-APDTPFVINSATGWVSVSGPL 784
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
DRESV + A D G+PP S++ V + + D+ND+ P F ++E++ +GT+
Sbjct: 785 DRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTS 844
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM-VDLDYESPRKKYE 764
+ + A D D N+ + Y I GG+ N F++ T+ G LVT+ + LDY+ R ++
Sbjct: 845 VVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGG---VGLVTLALPLDYKQER-YFK 898
Query: 765 LVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADV 823
LV+ A+ L + V I +TD N + PV + + +D P+G + A D DV
Sbjct: 899 LVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNED-RPMGSTIVVISASDDDV 957
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ + L +N ++ +G++TL L+ T+ ++ D
Sbjct: 958 GENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARD 1005
Score = 79.8 bits (188), Expect = 1e-13
Identities = 62/225 (27%), Positives = 102/225 (45%), Gaps = 29/225 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND++PVF +++E V+E + G+ V + A D D G NA + Y I
Sbjct: 1124 QVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQI------- 1176
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ ++F++D SG L LD E Y ++V+AT S
Sbjct: 1177 ------------VEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT------SAP 1218
Query: 130 LSSTATIHVNIIDDNDNYPQFS--EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L S AT+HV ++D NDN P + + + V + +I +I A D DV + +
Sbjct: 1219 LVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDV--SDHL 1276
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDG 232
Y+ GN ++ SG++ L + LD + +++ DG
Sbjct: 1277 FYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1321
Score = 40.3 bits (90), Expect = 0.097
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 1/93 (1%)
Query: 2238 CTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCLIRGGAATV 2297
C C+ TF VL+D E + L +V ++ ++S+ L+ + A L +R + V
Sbjct: 2582 CRCSRTGTFGVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNV 2641
Query: 2298 SNSIHKHLIFSVFMAELLYLIALKARTSLVQNE 2330
IH ++ ++ +AELL+L+ + + VQ++
Sbjct: 2642 -RGIHANVAAALGVAELLFLLGIHRTHNQVQDQ 2673
Score = 37.9 bits (84), Expect = 0.52
Identities = 15/39 (38%), Positives = 19/39 (48%)
Query: 1310 CPEKRSRCSSAPCYNGAECSDLWDTYICDCKEGHTGKDC 1348
C + C S PC NG C+ Y C C+ TG+DC
Sbjct: 1502 CETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDC 1540
>AF231023-1|AAF61929.1| 3312|Homo sapiens protocadherin Flamingo 1
protein.
Length = 3312
Score = 903 bits (2234), Expect = 0.0
Identities = 477/1085 (43%), Positives = 665/1085 (61%), Gaps = 52/1085 (4%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ V D NDHSPVFE QY ++RE G +L L+ATD D NA + Y +
Sbjct: 421 VTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRF-------V 473
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P A F ID RSG + T +DRE + Y ++V+A+DQ R
Sbjct: 474 GPPAARAAAAAA-------FEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPR- 525
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+T +H+ ++D+NDN PQFSEK Y V ED V + V+ ++ ATD D AN + Y
Sbjct: 526 SATVRVHITVLDENDNAPQFSEKRYVAQVRED--VRPHTVVLRVTATDRDKDANGLVHYN 583
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRD 249
II GN++ F+IDSL+G++ +V LD+E R Y L IRAQD G P SN T L I + D
Sbjct: 584 IISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVD 643
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
+ND+ P F ++ FQ SV EN P+G+S++ +QA DAD G NA L Y++T D P
Sbjct: 644 INDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVA----PDTPF 699
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
I+ +GWV SG LDRE+ Y V A D G PP SA+A+ F
Sbjct: 700 VINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMK 759
Query: 370 QYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPL 429
+Y + L ED GT VV++TA D D ++ + Y+ITGGNTR RF+I++Q G GL+T+A PL
Sbjct: 760 EYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPL 819
Query: 430 DFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
D+KQER + L ++A+D D V INITDAN + PVF++A Y+ SV ED P+G+T++
Sbjct: 820 DYKQERYFKLVLTASDRA-LHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIV 878
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
V+SA+D DVG NA+ITY L + QF I+ +GAIT LD E Y L
Sbjct: 879 VISASDDDVGENARITYLLEDNLP---------QFRIDADSGAITLQAPLDYEDQVTYTL 929
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
+TARD G+P +DTT VE+ V DVNDN P F YT + EDA TSV Q+ ATD D
Sbjct: 930 AITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRD 989
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
NGR+ Y + +G F I+P SG++RT + LDRE+V+ ++L A A+D G PP +
Sbjct: 990 AHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRT 1049
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
V + + ++D+ND+ PVF ++ + ENS +G+ + +I A DPDEGPNA + Y I G
Sbjct: 1050 PVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEG 1109
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVND 789
+ F ++ G EL ++DLDYE+ R++Y +V++A S PL + V + + D ND
Sbjct: 1110 NIPELFQMDIFSG----ELTALIDLDYEA-RQEYVIVVQATSAPLVSRATVHVRLVDQND 1164
Query: 790 NAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNET 845
N+PV+ +FQI+FNNY D FP G GR+PAYD DV+D L Y GN L+++N+T
Sbjct: 1165 NSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQT 1224
Query: 846 TGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTA 905
+G + LS +L+ N P +A+M V+VTDG++ + A L V +ITEE+L NS+TVRL +M
Sbjct: 1225 SGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVIITEELLANSLTVRLENMWQ 1284
Query: 906 EQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSARRP-DAEVGVAG 964
E+FLSPLLG F++G+AA++ P E+++IF++Q+DTDV G +LNVSFSA P A G AG
Sbjct: 1285 ERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDVGGTVLNVSFSALAPRGAGAGAAG 1344
Query: 965 DPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEECLTVLKFGNASG 1024
P +S L+E++Y+ R LA + + VLPFDDN+C+ EPC N+ +C++VL+F +++
Sbjct: 1345 ---PWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCLREPCENYMKCVSVLRFDSSAP 1401
Query: 1025 FVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARRE 1084
F+ S S LFRPI P+ C+CP GFTG CET L + CR+G C ARRE
Sbjct: 1402 FLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCY------SNPCRNGGAC-ARRE 1454
Query: 1085 GGILC 1089
GG C
Sbjct: 1455 GGYTC 1459
Score = 628 bits (1551), Expect = e-179
Identities = 348/912 (38%), Positives = 488/912 (53%), Gaps = 84/912 (9%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC C FTG +CE C V G +CR+G C GG CQ C A+
Sbjct: 1457 YTCVCRPRFTGEDCELDTEAGRC-VPG---VCRNGGTCTDAPNGGFRCQ-CPAGGAFEGP 1511
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
CE+ ARSFP SSF+ F GL++R + L L FAT SGLL YNGR NE+HDFLALELV+
Sbjct: 1512 RCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVA 1571
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEI--TVEGNVGDGSWHTVEIEYFNRTIT---------- 1209
+ +R ++S G + + TV G + DG WHTV + Y+N+ T
Sbjct: 1572 GQ--------VRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPS 1623
Query: 1210 ------MILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTETCHRFLDLTGPLQ 1263
+ +DDCD ++L A+ G Y+C A + T + + LDLTGPL
Sbjct: 1624 KDKVAVLSVDDCDVAVALQFGAEIG-NYSC---------AAAGVQTSS-KKSLDLTGPLL 1672
Query: 1264 IGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPCY 1323
+GG+PN+P +F V +KDF+GC+ D +ID + +D+ ++VA+NGT+AGC K C S PC
Sbjct: 1673 LGGVPNLPENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCK 1732
Query: 1324 NGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFN-PLLRPIQLPWLNALS 1382
N CS+ W ++ CDC G GKDC + P F G+G LS+N + +PW L+
Sbjct: 1733 NSGFCSERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLA 1792
Query: 1383 IRTRQRDAFVMSI----------QLKSGLLHY-----SYNGETMYLPMATLSDGAWH--R 1425
RTR +M + QL GLL S + L T+SDG WH R
Sbjct: 1793 FRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLR 1852
Query: 1426 IEIK-----WLGTDI-SVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDV 1479
+E++ G + V++D+ L M + +++QG + ++ +GGL + A
Sbjct: 1853 LELQEEPGGRRGHHVLMVSLDFSLFQDTM-AVGSELQGLKVKQLHVGGLPPGSAEEAPQ- 1910
Query: 1480 GFFEGCIQDVRIGTAQS---LLNRPTVRENVRDGCQSRADCMLSICPPYSKCVTSWDSST 1536
G GCIQ V +G+ S L P+ R N GC C CPP++ C W + +
Sbjct: 1911 GLV-GCIQGVWLGSTPSGSPALLPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFS 1969
Query: 1537 CTCEAGRVGPQCVSACELGPC---GAARCVPDQTPKGYSCACEPGYTLTTSGCIESGKEE 1593
CTC+ G GP CV AC L PC G+ R +P P GY+C C GY C ++
Sbjct: 1970 CTCQPGYYGPGCVDACLLNPCQNQGSCRHLPG-APHGYTCDCVGGY--FGHHCEHRMDQQ 2026
Query: 1594 CPGGWWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSEN 1653
CP GWWG CGPC CDV +G+ P+CNK NG+CHCKE HY+P G+ CLPC CY GS +
Sbjct: 2027 CPRGWWGSPTCGPCNCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTS 2086
Query: 1654 SSCEAATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFG 1713
SC +GQC CRPG +GR C++C + +AEVT SGC V+YD CP+S GVWWP+TKFG
Sbjct: 2087 RSCAPHSGQCPCRPGALGRQCNSCDSPFAEVTA-SGCRVLYDACPKSLRSGVWWPQTKFG 2145
Query: 1714 VETITDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTF 1773
V CP G+ G A R CDE + W +PD+FNCT+ F +L L +E + ++T
Sbjct: 2146 VLATVPCPRGALGAAVRLCDEAQG--WLEPDLFNCTSPAFRELSLLLDGLELNKTALDTM 2203
Query: 1774 VGVRVAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLK 1833
++A L +T + DV V +L L+ +E Q G LT +QD + NLL
Sbjct: 2204 EAKKLAQRLREVTGHTDHYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLW 2263
Query: 1834 STNTILNVEYEREWKRIRELT---GHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKD 1890
+ + +L E W + + G+ LV+ +EY A LA + TY +P +VT +
Sbjct: 2264 AGSALLAPETGDLWAALGQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPN 2323
Query: 1891 VVISVDTVTSES 1902
+++S+D + S
Sbjct: 2324 IMLSIDRMEHPS 2335
Score = 355 bits (872), Expect = 2e-96
Identities = 255/807 (31%), Positives = 390/807 (48%), Gaps = 42/807 (5%)
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY---AIIGGNTQMQFS 201
+ +PQF + Y V E+ + + ++ A D D G + Y A++ + FS
Sbjct: 320 NRHPQFPQYNYQTLVPENEAA--GTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 202 IDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
ID SG + LD E + + L + AQD GSP S TT + + + D ND++P F +
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT-GNVDLPITIDPRSGWVYT 320
++E++ ENV GY I++++A D D NA L Y IDPRSG + T
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 321 SGQLDRETQAKYQLLVTATD-GGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
SG++DRE Y+L+V A+D G +P PRSAT F +Y ++ ED
Sbjct: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
Query: 379 EPPGTPVVTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
P T V+ +TATD D+D +HY I GN+RG F+I S G I V PLDF+ ER
Sbjct: 558 VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGE--IQVVAPLDFEAERE 615
Query: 437 YVLTVSATDSGG---RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSA 493
Y L + A D+G ++T + I + D N++ P+F + P+ SV E+AP+G +V+ + A
Sbjct: 616 YALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQA 675
Query: 494 TDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D+D G NA++ YSL+ VA D FVIN TG ++ + LDRE++ Y V A
Sbjct: 676 VDADHGENARLEYSLT------GVA-PDTPFVINSATGWVSVSGPLDRESVEHYFFGVEA 728
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
RD G P LS + V ++V+DVNDN P F + Y + EDA VGTSV V A D D N
Sbjct: 729 RDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--N 786
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
I Y++ F I GV AL + K V + V
Sbjct: 787 SAISYQI-TGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLV-LTASDRALHDHCYV 844
Query: 674 HIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSN 733
HI I D N PVF+S + ++E+ P+G+TI I A D D G NA + Y ++ D+
Sbjct: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLP 902
Query: 734 SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDN 790
F ++ +D + LDYE + Y L I A P + VE++V DVNDN
Sbjct: 903 QFRID----ADSGAITLQAPLDYED-QVTYTLAITARDNGIPQKADTTYVEVMVNDVNDN 957
Query: 791 APVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNAN-LILLNETTG 847
AP +D P ++ A D D ++QY +G + + + T+G
Sbjct: 958 APQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSG 1017
Query: 848 SMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTAE 906
+ +L+ + + D GV ++ +S++++ +++ N+ +
Sbjct: 1018 IVRTVRRLDREAVSVYELTAYAVDRGVPPLRT--PVSIQVMVQDVNDNAPVFPAEEFEVR 1075
Query: 907 QFLSPLLGFFIDGLAAIIPCPKENIYI 933
+ ++G + + A+ P N +I
Sbjct: 1076 VKENSIVGSVVAQITAVDPDEGPNAHI 1102
Score = 343 bits (843), Expect = 6e-93
Identities = 272/912 (29%), Positives = 428/912 (46%), Gaps = 69/912 (7%)
Query: 17 NDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAX 76
N H P F Y+ V E ++GT VL + A D D G+ + Y++ A +N
Sbjct: 320 NRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSL----AALMNSRSL- 373
Query: 77 XXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATI 136
++F ID +SG + T A+LDRE + R+ + V A D SP RLS+T +
Sbjct: 374 -----------ELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMV 419
Query: 137 HVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIG--- 193
V + D ND+ P F + Y ++ E +V + I +++ATD D N+ +RY +G
Sbjct: 420 AVTVADRNDHSPVFEQAQYRETLRE--NVEEGYPILQLRATDGDAPPNANLRYRFVGPPA 477
Query: 194 --GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSP--SRSNTTQLLINIRD 249
F ID SG +S +D E + SY LV+ A D G RS T ++ I + D
Sbjct: 478 ARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLD 537
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
NDNAP+F + V E+V ++RV A D D+ N + Y + +GN
Sbjct: 538 ENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNI----ISGNSRGHF 593
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRS-ATATXXXXXXXXXXXXXXFMP 368
ID +G + LD E + +Y L + A D G PP S T F+
Sbjct: 594 AIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS 653
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVA 426
++V + E+ P G V+ + A DAD E+ RL Y +TG F I S G ++V+
Sbjct: 654 TPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINS--ATGWVSVS 711
Query: 427 QPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPI 484
PLD + Y V A D G S +A V + + D N+ P F Y + EDA +
Sbjct: 712 GPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAV 771
Query: 485 GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETM 544
GT+V+ V+A D D N+ I+Y ++ + A Q V G +T LD +
Sbjct: 772 GTSVVSVTAVDRDA--NSAISYQITGGNTRNRFAISTQGGV-----GLVTLALPLDYKQE 824
Query: 545 SGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVG 604
+ L +TA D +L D V I++ D N + PVF+ Y+ ++ ED +G+++ +
Sbjct: 825 RYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVIS 881
Query: 605 ATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGT 664
A+D DVG N RI Y L+ + F ID SG I LD E T+ L A D G
Sbjct: 882 ASDDDVGENARITYLLEDNLPQ---FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGI 938
Query: 665 PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHY 724
P ++ T V + + D+ND+ P F + T +SE++P T++ +I A D D N V Y
Sbjct: 939 PQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY 998
Query: 725 SIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEIL 783
+ + G+D + F++E G V +D + S + + PPL V ++++
Sbjct: 999 TFQNGEDGDGDFTIEPTSGI--VRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVM 1056
Query: 784 VTDVNDNAPVM--KDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNAN 838
V DVNDNAPV ++F++ K+ VG ++ A D D + Y+I+ GN
Sbjct: 1057 VQDVNDNAPVFPAEEFEV---RVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPE 1113
Query: 839 LILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITE---EMLLNS 895
L ++ +G +T L+ + + V T + + + VRL+ + +LN+
Sbjct: 1114 LFQMDIFSGELTALIDLDYEARQEYVIVVQATSA--PLVSRATVHVRLVDQNDNSPVLNN 1171
Query: 896 ITVRLNDMTAEQ 907
+ N+ + +
Sbjct: 1172 FQILFNNYVSNR 1183
Score = 309 bits (758), Expect = 1e-82
Identities = 227/734 (30%), Positives = 358/734 (48%), Gaps = 56/734 (7%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
+ I VLD ND++P F ++Y A VRE T VL + ATD+D N V Y I ++
Sbjct: 529 VRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNI--IS 586
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
++ + F ID +G + A LD E Y + ++A D P
Sbjct: 587 GNS-----------------RGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPP 629
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
++T + ++D ND+ P F + VSV E+ + + + I+A DAD G N+
Sbjct: 630 LS--NNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHS--VIHIQAVDADHGENAR 685
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ Y++ G F I+S +G VS+ LD E V Y + A+D GSP S + + +
Sbjct: 686 LEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVT 745
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDN P F + ++E+ +G S+V V A D D N+ ++Y +T + T N
Sbjct: 746 VLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGN-TRN-R 801
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I+ G V + LD + + ++L++TA+D F
Sbjct: 802 FAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANTHRPVF 858
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
Y V + ED P G+ +V ++A+D D E+ R+ Y + + R S G IT
Sbjct: 859 QSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADS----GAIT 914
Query: 425 VAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+ PLD++ + Y L ++A D+G ++DT V++ + D N+ AP F + YT V EDA
Sbjct: 915 LQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDA 974
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
P T+VL +SATD D N ++ Y+ + D F I P +G + T + LDRE
Sbjct: 975 PPFTSVLQISATDRDAHANGRVQYTFQNGEDG------DGDFTIEPTSGIVRTVRRLDRE 1028
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
+S Y LT A D GVP L +++ V DVNDN PVF + + + E+++VG+ V+Q
Sbjct: 1029 AVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQ 1088
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDG 662
+ A D D G N I Y++ + E F +D SG + LD E+ + + +
Sbjct: 1089 ITAVDPDEGPNAHIMYQIVEGNIPE-LFQMDIFSGELTALIDLDYEARQEY---VIVVQA 1144
Query: 663 GTPPQSSTVIVHIKIEDINDSPPVFESDCLTF--YISENS---PIGTTIGEIRAHDPDEG 717
+ P S VH+++ D ND+ PV + + F Y+S S P G IG I A+DPD
Sbjct: 1145 TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVS 1203
Query: 718 PNAVVHYSIKGGDD 731
+ + YS + G++
Sbjct: 1204 DH--LFYSFERGNE 1215
Score = 271 bits (665), Expect = 2e-71
Identities = 202/648 (31%), Positives = 310/648 (47%), Gaps = 28/648 (4%)
Query: 236 SRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT 295
+R T+ R + P+F +Q V EN G +++RV A D D G L Y+
Sbjct: 304 ARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYS 363
Query: 296 MTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXX 355
+ + +++L +IDP+SG + T+ LDRE+ ++ L VTA D G P SAT
Sbjct: 364 LAALMNSRSLEL-FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVT 422
Query: 356 XXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITG---GNTRG 410
F QY L E+ G P++ L ATD D + L Y G
Sbjct: 423 VADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAA 482
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS----GGRSDTAMVQINITDANNYA 466
+ GLI+ + +D + Y L V A+D G RS T V I + D N+ A
Sbjct: 483 AAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA 542
Query: 467 PVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
P F Y A V ED T VL V+ATD D N + Y++ IS + H F I
Sbjct: 543 PQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNI---ISGNSRGH----FAI 595
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV-EISVVDVNDNEPVFKQQL 585
+ TG I LD E Y L + A+D G P LS+ T + I VVD+ND+ P+F
Sbjct: 596 DSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTP 655
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKAL 645
+ +++E+A +G SV + A DAD G N R+ Y L + FVI+ A+G + + L
Sbjct: 656 FQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGV-APDTPFVINSATGWVSVSGPL 714
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
DRESV + A D G+PP S++ V + + D+ND+ P F ++E++ +GT+
Sbjct: 715 DRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTS 774
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM-VDLDYESPRKKYE 764
+ + A D D N+ + Y I GG+ N F++ T+ G LVT+ + LDY+ R ++
Sbjct: 775 VVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGG---VGLVTLALPLDYKQER-YFK 828
Query: 765 LVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADV 823
LV+ A+ L + V I +TD N + PV + + +D P+G + A D DV
Sbjct: 829 LVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNED-RPMGSTIVVISASDDDV 887
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ + L +N ++ +G++TL L+ T+ ++ D
Sbjct: 888 GENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARD 935
Score = 79.8 bits (188), Expect = 1e-13
Identities = 62/225 (27%), Positives = 102/225 (45%), Gaps = 29/225 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND++PVF +++E V+E + G+ V + A D D G NA + Y I
Sbjct: 1054 QVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQI------- 1106
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ ++F++D SG L LD E Y ++V+AT S
Sbjct: 1107 ------------VEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT------SAP 1148
Query: 130 LSSTATIHVNIIDDNDNYPQFS--EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L S AT+HV ++D NDN P + + + V + +I +I A D DV + +
Sbjct: 1149 LVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDV--SDHL 1206
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDG 232
Y+ GN ++ SG++ L + LD + +++ DG
Sbjct: 1207 FYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDG 1251
Score = 37.9 bits (84), Expect = 0.52
Identities = 15/39 (38%), Positives = 19/39 (48%)
Query: 1310 CPEKRSRCSSAPCYNGAECSDLWDTYICDCKEGHTGKDC 1348
C + C S PC NG C+ Y C C+ TG+DC
Sbjct: 1432 CETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDC 1470
Score = 37.9 bits (84), Expect = 0.52
Identities = 23/83 (27%), Positives = 44/83 (53%), Gaps = 1/83 (1%)
Query: 2238 CTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCLIRGGAATV 2297
C C+ TF VL+D E + L +V ++ ++S+ L+ + A L +R + V
Sbjct: 2512 CRCSRTGTFGVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNV 2571
Query: 2298 SNSIHKHLIFSVFMAELLYLIAL 2320
IH ++ ++ +AELL+L+ +
Sbjct: 2572 -RGIHANVAAALGVAELLFLLGI 2593
>D87469-1|BAA13407.2| 2854|Homo sapiens KIAA0279 protein protein.
Length = 2854
Score = 901 bits (2230), Expect = 0.0
Identities = 492/1105 (44%), Positives = 668/1105 (60%), Gaps = 58/1105 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D NDH PVFE Q+Y+ S+RE G VLT++ATD D NA + Y L+
Sbjct: 208 ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILY--RLLEGSGG 265
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+P + VF ID RSG + TR +DRE+V Y + V+A+DQ R
Sbjct: 266 SPSE--------------VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPR- 310
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+TA + +++ DDNDN PQFSEK Y V V ED VT + ++ A+D D G+N+ + Y+
Sbjct: 311 STTAAVFLSVEDDNDNAPQFSEKRYVVQVRED--VTPGAPVLRVTASDRDKGSNAVVHYS 368
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRD 249
I+ GN + QF +D+ +G + +V LDYE + Y L +RAQDGG P SN + L+ + + D
Sbjct: 369 IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLD 428
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
+NDNAP F ++ FQ +V E+VP+GY ++ VQA DAD G NA L Y + + D P
Sbjct: 429 INDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGH----DFPF 484
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
TI+ +GW+ + +LDRE Y V A D G P +A+A+ F
Sbjct: 485 TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQP 544
Query: 370 QYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPL 429
+Y V L ED GT VVT++A D D + + Y+IT GNTR RFSITSQ+G GL+++A PL
Sbjct: 545 EYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPL 604
Query: 430 DFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
D+K ER+YVL V+A+D G R DTA + +N+TDAN + PVF+++ YT +V ED P GTTV+
Sbjct: 605 DYKLERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 663
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
++SATD D G NA+ITY + I QF I+ TGA+TT LD E Y L
Sbjct: 664 LISATDEDTGENARITYFMEDSIP---------QFRIDADTGAVTTQAELDYEDQVSYTL 714
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
+TARD G+P SDTT +EI V DVNDN P F + Y ++ ED TSV Q+ ATD D
Sbjct: 715 AITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 774
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GLNGR+ Y D +G F+++ SG++RT + LDRE+VA + L+A A+D G PP +
Sbjct: 775 SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPART 834
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
+ V + + D+ND+PPVFE D ++ ENSPIG + + A DPDEG NA + Y I G
Sbjct: 835 PMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEG 894
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVND 789
+ F L+ G EL +VDLDYE R +Y LVI+A S PL + V + + D ND
Sbjct: 895 NIPEVFQLDIFSG----ELTALVDLDYED-RPEYVLVIQATSAPLVSRATVHVRLLDRND 949
Query: 790 NAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNET 845
N PV+ +F+I+FNNY FP G GRVPA+D D++D L Y GN +L+LLN +
Sbjct: 950 NPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAS 1009
Query: 846 TGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTA 905
TG + LS L+ N P A M V V+DGV+ + A L V +IT+EML +SIT+RL DM+
Sbjct: 1010 TGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSP 1069
Query: 906 EQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVT-GNILNVSFSARRPDAEVGVAG 964
E+FLSPLLG FI +AA + P +++ +F+VQ DTD G+ILNVS S +P G G
Sbjct: 1070 ERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPP---GPGG 1126
Query: 965 DPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEECLTVLKFGNASG 1024
P P L+ER+YL+R+ L ++ +VLPFDDNIC+ EPC N+ C++VL+F +++
Sbjct: 1127 GP-PFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAP 1185
Query: 1025 FVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARRE 1084
F+ S SVLFRPI+PV C+CP GFTG CET + G CRS RE
Sbjct: 1186 FIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRS-------RE 1238
Query: 1085 GGILCQGCSIDAAYTTAVCELRARS 1109
GG C C YT CE+ ARS
Sbjct: 1239 GGYTCL-CR--DGYTGEHCEVSARS 1260
Score = 625 bits (1545), Expect = e-178
Identities = 337/941 (35%), Positives = 499/941 (53%), Gaps = 82/941 (8%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC C +G+TG +CE C +C++G CV GG C S D +
Sbjct: 1241 YTCLCRDGYTGEHCEVSARSGRCTP----GVCKNGGTCVNLLVGGFKCDCPSGD--FEKP 1294
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
C++ RSFP SF+TF GL++R L L FAT+ GLLLYNGR+NE+HDF+ALE++
Sbjct: 1295 YCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQ 1354
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEIT--VEGNVGDGSWHTVEIEYFNRTI----------- 1208
+ ++ +FS G + ++ V G V DG WHTV+++Y+N+ +
Sbjct: 1355 EQ--------VQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPS 1406
Query: 1209 -----TMILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTETCHRFLDLTGPLQ 1263
+ +D CD ++L + G Y+CA + + LDLTGPL
Sbjct: 1407 EQKVAVVTVDGCDTGVALRFGSVLG-NYSCA----------AQGTQGGSKKSLDLTGPLL 1455
Query: 1264 IGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPCY 1323
+GG+P++P SF V+ + FVGC+ + +D + ID+ ++A+NGT+ GCP K++ C S C+
Sbjct: 1456 LGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCH 1515
Query: 1324 NGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFNPLLRPIQLPWLNALSI 1383
NG C + WD + C+C G GK CA P F G +++++ L PI PW +L
Sbjct: 1516 NGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWHLSLMF 1575
Query: 1384 RTRQRDAFVM----------SIQLKSGLLHYSYNG-----ETMYLPMATLSDGAWHRIEI 1428
RTRQ D ++ ++QL+ G + S G ++ L +DG WH ++
Sbjct: 1576 RTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQL 1635
Query: 1429 KWLGTD-----ISVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDVGFFE 1483
LG ++ DYG + L ++ G ++ I +GG+ AG +A F
Sbjct: 1636 A-LGASGGPGHAILSFDYGQQRA-EGNLGPRLHGLHLSNITVGGIPGPAGGVARG---FR 1690
Query: 1484 GCIQDVRIGTAQSLLNR--PTVRE--NVRDGCQSRADCMLSICPPYSKCVTSWDSSTCTC 1539
GC+Q VR+ +N P+ E NV GC C + CP S C WDS +C+C
Sbjct: 1691 GCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSC 1750
Query: 1540 EAGRVGPQCVSACELGPCG-AARCV-PDQTPKGYSCACEPGYTLTTSGCIESGKEECPGG 1597
+ G G C + C+L PC + C P GY+C C P Y C + CP G
Sbjct: 1751 DPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYL--GPYCETRIDQPCPRG 1808
Query: 1598 WWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSENSSCE 1657
WWG CGPC CDV++G+ P CNK +G+CHCKENHY+P G+ CL C CY GS + C+
Sbjct: 1809 WWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCD 1868
Query: 1658 AATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFGVETI 1717
GQC C+PGVIGR CD C N +AEVT N GCEV YD CPR+ G+WWPRT+FG+
Sbjct: 1869 PEDGQCPCKPGVIGRQCDRCDNPFAEVTTN-GCEVNYDSCPRAIEAGIWWPRTRFGLPAA 1927
Query: 1718 TDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTFVGVR 1777
CP GS G A R CDE + W P++FNCT+ TF +L+ +++ E +++ +
Sbjct: 1928 APCPKGSFGTAVRHCDEHRG--WLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQ 1985
Query: 1778 VAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLKSTNT 1837
+A L A +T +G+DV VA + L+ +E Q G L+ +QD + NLL+ +
Sbjct: 1986 LALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSA 2045
Query: 1838 ILNVEYEREWKRIRELTGHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKDVVISVDT 1897
+L+ +R W+ I++ G G L+Q ++ Y + LA++ TY SPF IVT ++VISV
Sbjct: 2046 LLDTANKRHWELIQQTEG-GTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVR 2104
Query: 1898 VTSESIYGFEPTQLNRLNVDS-YTTERVVALPDTSAFIHSP 1937
+ + G + + L + E V LP+ S F +P
Sbjct: 2105 LDKGNFAGAKLPRYEALRGEQPPDLETTVILPE-SVFRETP 2144
Score = 363 bits (892), Expect = 6e-99
Identities = 253/759 (33%), Positives = 374/759 (49%), Gaps = 44/759 (5%)
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY---AIIGGNTQMQFSIDS 204
PQF +Y +V E+ PV A ++A D D G + Y A+ + FS+D
Sbjct: 110 PQFQPPSYQATVPEN-QPAGTPV-ASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDP 167
Query: 205 LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++G V+ + LD E ++ + AQD G P RS L I + D ND+ P F ++E
Sbjct: 168 VTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKE 227
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
S+ EN+ +GY ++ V+A D D NA + Y + + G+ IDPRSG + T G +
Sbjct: 228 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGS-GGSPSEVFEIDPRSGVIRTRGPV 286
Query: 325 DRETQAKYQLLVTATD-GGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
DRE YQL V A+D G DP PRS TA F +Y V++ ED PG
Sbjct: 287 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 346
Query: 383 TPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
PV+ +TA+D D+ + +HY I GN RG+F + +Q G + V PLD++ + Y L
Sbjct: 347 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT--GALDVVSPLDYETTKEYTLR 404
Query: 441 VSATDSGGR----SDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
V A D GGR + + +V + + D N+ AP+F + P+ A+V E P+G VL V A D+
Sbjct: 405 VRAQD-GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 463
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
D G NA++ Y L A HD F IN TG I+ LDRE + Y V ARD
Sbjct: 464 DAGDNARLEYRL-------AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDH 516
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
G P+L+ + V ++V+DVNDN P F Q YT + EDA VGTSV V A D D + I
Sbjct: 517 GTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVI 574
Query: 617 HYEL-DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
Y++ R S G++ LD + + L A DG + T + +
Sbjct: 575 TYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVV 631
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ D N PVF+S T ++E+ P GTT+ I A D D G NA + Y ++ D F
Sbjct: 632 NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQF 689
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAP 792
++ +D + T +LDYE + Y L I A P + +EILV DVNDNAP
Sbjct: 690 RID----ADTGAVTTQAELDYED-QVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAP 744
Query: 793 VMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSM- 849
+ Y+D P ++ A D D + ++ Y G++ + + E+T +
Sbjct: 745 QFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIV 804
Query: 850 -TLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLI 887
TL NV + +V G+ + M+++V ++
Sbjct: 805 RTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVL 843
Score = 361 bits (888), Expect = 2e-98
Identities = 273/851 (32%), Positives = 414/851 (48%), Gaps = 69/851 (8%)
Query: 20 SPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAXXXX 79
+P F+ Y+A+V E +GT V +L+A D D G+ +EYT++ + N
Sbjct: 109 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSN-------- 160
Query: 80 XXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVN 139
F +D +GA+ T LDRE + + V A D P R S+ AT+ +
Sbjct: 161 --------QFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMP---RRSALATLTIL 209
Query: 140 IIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII---GGNT 196
+ D ND+ P F ++ Y S+ E++ V + ++ATD D N+ I Y ++ GG+
Sbjct: 210 VTDTNDHDPVFEQQEYKESLRENLEV--GYEVLTVRATDGDAPPNANILYRLLEGSGGSP 267
Query: 197 QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQD-GGSPS-RSNTTQLLINIRDVNDNA 254
F ID SG + +D E+V SY+L + A D G P RS T + +++ D NDNA
Sbjct: 268 SEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 327
Query: 255 PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPR 314
P+F + V E+V G ++RV A D D+G NA + Y++ +GN +D +
Sbjct: 328 PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSI----MSGNARGQFYLDAQ 383
Query: 315 SGWVYTSGQLDRETQAKYQLLVTATDGGDPPRS-ATATXXXXXXXXXXXXXXFMPGQYEV 373
+G + LD ET +Y L V A DGG PP S + F+ ++
Sbjct: 384 TGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA 443
Query: 374 ELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGRFSITSQNGRGLITVAQPLDF 431
+ E P G V+ + A DAD DN RL Y + G F T NG G I+VA LD
Sbjct: 444 TVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG--VGHDFPFTINNGTGWISVAAELDR 501
Query: 432 KQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGTTVL 489
++ Y V A D G + TA +++T D N+ P F YT + EDA +GT+V+
Sbjct: 502 EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 561
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA--ITTNKLLDRETMSGY 547
VSA D D ++ ITY ++S + +F I Q+G ++ LD + Y
Sbjct: 562 TVSAVDRDA--HSVITYQITS-------GNTRNRFSITSQSGGGLVSLALPLDYKLERQY 612
Query: 548 LLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATD 607
+L VTA DG + DT + ++V D N + PVF+ YT N+ ED GT+V + ATD
Sbjct: 613 VLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 669
Query: 608 ADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
D G N RI Y ++ + F ID +G + T LD E ++ L A D G P +
Sbjct: 670 EDTGENARITYFMEDSIPQ---FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK 726
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIK 727
S T + I + D+ND+ P F D + E+ P T++ +I A D D G N V Y+ +
Sbjct: 727 SDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ 786
Query: 728 GGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYEL---VIRAASPPLWNDVRVEIL 783
GGDD + F +E+ G + T+ LD E+ +Y L + PP + V +
Sbjct: 787 GGDDGDGDFIVESTSGIVR----TLRRLDRENV-AQYVLRAYAVDKGMPPARTPMEVTVT 841
Query: 784 VTDVNDNAPVMKDFQI-IFNNYKDCFPVG-PFGRVPAYDAD--VTDKLQYRILSGNNANL 839
V DVNDN PV + + +F ++ P+G RV A D D ++ Y+I+ GN +
Sbjct: 842 VLDVNDNPPVFEQDEFDVF--VEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEV 899
Query: 840 ILLNETTGSMT 850
L+ +G +T
Sbjct: 900 FQLDIFSGELT 910
Score = 281 bits (688), Expect = 3e-74
Identities = 203/635 (31%), Positives = 311/635 (48%), Gaps = 29/635 (4%)
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
R+VN AP+F +Q +V EN P G + ++A D DEG L YTM D + +
Sbjct: 104 RNVN-TAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM-DALFDSRSNQ 161
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++DP +G V T+ +LDRET++ + VTA D G P RSA AT F
Sbjct: 162 FFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFE 221
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDAD---EDNRLH--YEITGGNTRGRFSITSQNGRGL 422
+Y+ L E+ G V+T+ ATD D N L+ E +GG+ F I ++ G+
Sbjct: 222 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRS--GV 279
Query: 423 ITVAQPLDFKQERRYVLTVSATDS----GGRSDTAMVQINITDANNYAPVFENAPYTASV 478
I P+D ++ Y LTV A+D G RS TA V +++ D N+ AP F Y V
Sbjct: 280 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 339
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED G VL V+A+D D G NA + YS+ S + QF ++ QTGA+
Sbjct: 340 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMS-------GNARGQFYLDAQTGALDVVSP 392
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LD ET Y L V A+DGG P LS+ + V + V+D+NDN P+F + A ++E +G
Sbjct: 393 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 452
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
V V A DAD G N R+ Y L + F I+ +G I LDRE V +
Sbjct: 453 YLVLHVQAIDADAGDNARLEYRLAGVG-HDFPFTINNGTGWISVAAELDREEVDFYSFGV 511
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTP +++ V + + D+ND+ P F T ++E++ +GT++ + A D D
Sbjct: 512 EARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD-- 569
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
++V+ Y I G+ N FS+ ++ G L + LDY+ R +Y L + A+ +
Sbjct: 570 AHSVITYQITSGNTRNRFSITSQSGGGLVSLA--LPLDYKLER-QYVLAVTASDGTRQDT 626
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNN 836
++ + VTD N + PV + N +D P G + A D D + + ++
Sbjct: 627 AQIVVNVTDANTHRPVFQSSHYTVNVNED-RPAGTTVVLISATDEDTGENARITYFMEDS 685
Query: 837 ANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
++ TG++T +L+ T+ ++ D
Sbjct: 686 IPQFRIDADTGAVTTQAELDYEDQVSYTLAITARD 720
Score = 214 bits (523), Expect = 3e-54
Identities = 155/438 (35%), Positives = 223/438 (50%), Gaps = 26/438 (5%)
Query: 464 NYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQ 523
N AP F+ Y A+V E+ P GT V + A D D G ++ Y++ + + + +Q
Sbjct: 107 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRS----NQF 162
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ 583
F ++P TGA+TT + LDRET S ++ VTA+D G+P S + I V D ND++PVF+Q
Sbjct: 163 FSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQ 222
Query: 584 QLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRT 641
Q Y ++ E+ VG V V ATD D N I Y L S F IDP SGVIRT
Sbjct: 223 QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 282
Query: 642 NKALDRESVATHDLKAVAIDGGTP--PQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
+DRE V ++ L A D G P+S+T V + +ED ND+ P F + E+
Sbjct: 283 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED 342
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
G + + A D D+G NAVVHYSI G+ F L+ + G+ L + LDYE+
Sbjct: 343 VTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDYET- 397
Query: 760 RKKYELVIRA---ASPPLWN-DVRVEILVTDVNDNAP--VMKDFQIIFNNYKDCFPVGPF 813
K+Y L +RA PPL N V + V D+NDNAP V FQ + P+G
Sbjct: 398 TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA---TVLESVPLGYL 454
Query: 814 G-RVPAYDADVTD--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVT 870
V A DAD D +L+YR+ + +N TG ++++ +L+ + V
Sbjct: 455 VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 514
Query: 871 D-GVNEIKAMMQLSVRLI 887
D G + A +SV ++
Sbjct: 515 DHGTPALTASASVSVTVL 532
Score = 125 bits (301), Expect = 3e-27
Identities = 104/337 (30%), Positives = 159/337 (47%), Gaps = 38/337 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P F Y+ SV E T+VL + ATD+D G N V YT +
Sbjct: 733 EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ------ 786
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D F ++ SG + T LDRE VA+Y + A D+ P +
Sbjct: 787 -GGDDGDGD-----------FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPA-- 832
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+ + V ++D NDN P F + + V V+E+ + +A++ ATD D G N+ I Y
Sbjct: 833 -RTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI--GLAVARVTATDPDEGTNAQIMY 889
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
I+ GN F +D SG+++ + LDYE Y LVI+A SR+ + + + D
Sbjct: 890 QIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRAT---VHVRLLD 946
Query: 250 VNDNAPRF--YTSLFQESV---SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
NDN P + LF V S + P G +I RV A+D D ++ LTY+ GN
Sbjct: 947 RNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPD--ISDSLTYSFE----RGN 999
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG 341
+ ++ +G + S LD + + V +DG
Sbjct: 1000 ELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1036
Score = 54.8 bits (126), Expect = 4e-06
Identities = 45/148 (30%), Positives = 79/148 (53%), Gaps = 18/148 (12%)
Query: 2176 LKKPIRLQIWLDINRETFGSRTNPQCVHWS---TLRGSGEWSRVGCHTEIDYDWSPYSEE 2232
L KP+ +Q L E RT P CV W+ + G+G WS GC E+ + +
Sbjct: 2229 LDKPVTVQFRLLETEE----RTKPICVFWNHSILVSGTGGWSARGC--EVVFRNESH--- 2279
Query: 2233 PLLINCTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCLIRG 2292
++C CNH+++FAVL+D V E L+++T Y A ++L LL ++ L L+R
Sbjct: 2280 ---VSCQCNHMTSFAVLMD-VSRRENGEILPLKTLT-YVALGVTLAALLLTFFFLTLLR- 2333
Query: 2293 GAATVSNSIHKHLIFSVFMAELLYLIAL 2320
+ + I ++L ++ +A+L++L+ +
Sbjct: 2334 ILRSNQHGIRRNLTAALGLAQLVFLLGI 2361
Score = 37.5 bits (83), Expect = 0.69
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 6/76 (7%)
Query: 1509 DGCQSRAD-CMLSICPPYSKCVTSWDSSTCTCEAGRVGPQC-VSA----CELGPCGAARC 1562
D C++ D C C P+ +C + TC C G G C VSA C G C
Sbjct: 1214 DYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGT 1273
Query: 1563 VPDQTPKGYSCACEPG 1578
+ G+ C C G
Sbjct: 1274 CVNLLVGGFKCDCPSG 1289
Score = 35.1 bits (77), Expect = 3.7
Identities = 32/96 (33%), Positives = 36/96 (37%), Gaps = 17/96 (17%)
Query: 1537 CTCEAGRVGPQC---VSACELGPCGA-ARCVPDQTPKGYSCACEPGYTLTTSGCIESGKE 1592
C C G G C V C PCG RC + GY+C C GY T C S +
Sbjct: 1205 CRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREG--GYTCLCRDGY--TGEHCEVSARS 1260
Query: 1593 -EC-PGGWWGGSAC-----GPCACDVTRG--YHPHC 1619
C PG G C G CD G P+C
Sbjct: 1261 GRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYC 1296
Score = 33.9 bits (74), Expect = 8.5
Identities = 13/39 (33%), Positives = 18/39 (46%)
Query: 1310 CPEKRSRCSSAPCYNGAECSDLWDTYICDCKEGHTGKDC 1348
C + C S PC C Y C C++G+TG+ C
Sbjct: 1216 CETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHC 1254
>AL390252-1|CAI13170.1| 2923|Homo sapiens cadherin, EGF LAG seven-pass
G-type receptor 2 (flamingo homolog, Drosophila) protein.
Length = 2923
Score = 901 bits (2230), Expect = 0.0
Identities = 492/1105 (44%), Positives = 668/1105 (60%), Gaps = 58/1105 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D NDH PVFE Q+Y+ S+RE G VLT++ATD D NA + Y L+
Sbjct: 277 ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILY--RLLEGSGG 334
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+P + VF ID RSG + TR +DRE+V Y + V+A+DQ R
Sbjct: 335 SPSE--------------VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPR- 379
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+TA + +++ DDNDN PQFSEK Y V V ED VT + ++ A+D D G+N+ + Y+
Sbjct: 380 STTAAVFLSVEDDNDNAPQFSEKRYVVQVRED--VTPGAPVLRVTASDRDKGSNAVVHYS 437
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRD 249
I+ GN + QF +D+ +G + +V LDYE + Y L +RAQDGG P SN + L+ + + D
Sbjct: 438 IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLD 497
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
+NDNAP F ++ FQ +V E+VP+GY ++ VQA DAD G NA L Y + + D P
Sbjct: 498 INDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGH----DFPF 553
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
TI+ +GW+ + +LDRE Y V A D G P +A+A+ F
Sbjct: 554 TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQP 613
Query: 370 QYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPL 429
+Y V L ED GT VVT++A D D + + Y+IT GNTR RFSITSQ+G GL+++A PL
Sbjct: 614 EYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPL 673
Query: 430 DFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
D+K ER+YVL V+A+D G R DTA + +N+TDAN + PVF+++ YT +V ED P GTTV+
Sbjct: 674 DYKLERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 732
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
++SATD D G NA+ITY + I QF I+ TGA+TT LD E Y L
Sbjct: 733 LISATDEDTGENARITYFMEDSIP---------QFRIDADTGAVTTQAELDYEDQVSYTL 783
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
+TARD G+P SDTT +EI V DVNDN P F + Y ++ ED TSV Q+ ATD D
Sbjct: 784 AITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GLNGR+ Y D +G F+++ SG++RT + LDRE+VA + L+A A+D G PP +
Sbjct: 844 SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPART 903
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
+ V + + D+ND+PPVFE D ++ ENSPIG + + A DPDEG NA + Y I G
Sbjct: 904 PMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEG 963
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVND 789
+ F L+ G EL +VDLDYE R +Y LVI+A S PL + V + + D ND
Sbjct: 964 NIPEVFQLDIFSG----ELTALVDLDYED-RPEYVLVIQATSAPLVSRATVHVRLLDRND 1018
Query: 790 NAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNET 845
N PV+ +F+I+FNNY FP G GRVPA+D D++D L Y GN +L+LLN +
Sbjct: 1019 NPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAS 1078
Query: 846 TGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTA 905
TG + LS L+ N P A M V V+DGV+ + A L V +IT+EML +SIT+RL DM+
Sbjct: 1079 TGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSP 1138
Query: 906 EQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVT-GNILNVSFSARRPDAEVGVAG 964
E+FLSPLLG FI +AA + P +++ +F+VQ DTD G+ILNVS S +P G G
Sbjct: 1139 ERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPP---GPGG 1195
Query: 965 DPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEECLTVLKFGNASG 1024
P P L+ER+YL+R+ L ++ +VLPFDDNIC+ EPC N+ C++VL+F +++
Sbjct: 1196 GP-PFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAP 1254
Query: 1025 FVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARRE 1084
F+ S SVLFRPI+PV C+CP GFTG CET + G CRS RE
Sbjct: 1255 FIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRS-------RE 1307
Query: 1085 GGILCQGCSIDAAYTTAVCELRARS 1109
GG C C YT CE+ ARS
Sbjct: 1308 GGYTCL-CR--DGYTGEHCEVSARS 1329
Score = 626 bits (1547), Expect = e-178
Identities = 337/941 (35%), Positives = 499/941 (53%), Gaps = 82/941 (8%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC C +G+TG +CE C +C++G CV GG C S D +
Sbjct: 1310 YTCLCRDGYTGEHCEVSARSGRCTP----GVCKNGGTCVNLLVGGFKCDCPSGD--FEKP 1363
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
C++ RSFP SF+TF GL++R L L FAT+ GLLLYNGR+NE+HDF+ALE++
Sbjct: 1364 YCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQ 1423
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEIT--VEGNVGDGSWHTVEIEYFNRTI----------- 1208
+ ++ +FS G + ++ V G V DG WHTV+++Y+N+ +
Sbjct: 1424 EQ--------VQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPS 1475
Query: 1209 -----TMILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTETCHRFLDLTGPLQ 1263
+ +D CD ++L + G Y+CA + + LDLTGPL
Sbjct: 1476 EQKVAVVTVDGCDTGVALRFGSVLG-NYSCA----------AQGTQGGSKKSLDLTGPLL 1524
Query: 1264 IGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPCY 1323
+GG+P++P SF V+ + FVGC+ + +D + ID+ ++A+NGT+ GCP K++ C S C+
Sbjct: 1525 LGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCH 1584
Query: 1324 NGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFNPLLRPIQLPWLNALSI 1383
NG C + WD + C+C G GK CA P F G +++++ L PI PW +L
Sbjct: 1585 NGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMF 1644
Query: 1384 RTRQRDAFVM----------SIQLKSGLLHYSYNG-----ETMYLPMATLSDGAWHRIEI 1428
RTRQ D ++ ++QL+ G + S G ++ L +DG WH ++
Sbjct: 1645 RTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQL 1704
Query: 1429 KWLGTD-----ISVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDVGFFE 1483
LG ++ DYG + L ++ G ++ I +GG+ AG +A F
Sbjct: 1705 A-LGASGGPGHAILSFDYGQQRA-EGNLGPRLHGLHLSNITVGGIPGPAGGVARG---FR 1759
Query: 1484 GCIQDVRIGTAQSLLNR--PTVRE--NVRDGCQSRADCMLSICPPYSKCVTSWDSSTCTC 1539
GC+Q VR+ +N P+ E NV GC C + CP S C WDS +C+C
Sbjct: 1760 GCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSC 1819
Query: 1540 EAGRVGPQCVSACELGPCG-AARCV-PDQTPKGYSCACEPGYTLTTSGCIESGKEECPGG 1597
+ G G C + C+L PC + C P GY+C C P Y C + CP G
Sbjct: 1820 DPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYL--GPYCETRIDQPCPRG 1877
Query: 1598 WWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSENSSCE 1657
WWG CGPC CDV++G+ P CNK +G+CHCKENHY+P G+ CL C CY GS + C+
Sbjct: 1878 WWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCD 1937
Query: 1658 AATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFGVETI 1717
GQC C+PGVIGR CD C N +AEVT N GCEV YD CPR+ G+WWPRT+FG+
Sbjct: 1938 PEDGQCPCKPGVIGRQCDRCDNPFAEVTTN-GCEVNYDSCPRAIEAGIWWPRTRFGLPAA 1996
Query: 1718 TDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTFVGVR 1777
CP GS G A R CDE + W P++FNCT+ TF +L+ +++ E +++ +
Sbjct: 1997 APCPKGSFGTAVRHCDEHRG--WLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQ 2054
Query: 1778 VAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLKSTNT 1837
+A L A +T +G+DV VA + L+ +E Q G L+ +QD + NLL+ +
Sbjct: 2055 LALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSA 2114
Query: 1838 ILNVEYEREWKRIRELTGHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKDVVISVDT 1897
+L+ +R W+ I++ G G L+Q ++ Y + LA++ TY SPF IVT ++VISV
Sbjct: 2115 LLDTANKRHWELIQQTEG-GTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVR 2173
Query: 1898 VTSESIYGFEPTQLNRLNVDS-YTTERVVALPDTSAFIHSP 1937
+ + G + + L + E V LP+ S F +P
Sbjct: 2174 LDKGNFAGAKLPRYEALRGEQPPDLETTVILPE-SVFRETP 2213
Score = 363 bits (892), Expect = 6e-99
Identities = 253/759 (33%), Positives = 374/759 (49%), Gaps = 44/759 (5%)
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY---AIIGGNTQMQFSIDS 204
PQF +Y +V E+ PV A ++A D D G + Y A+ + FS+D
Sbjct: 179 PQFQPPSYQATVPEN-QPAGTPV-ASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDP 236
Query: 205 LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++G V+ + LD E ++ + AQD G P RS L I + D ND+ P F ++E
Sbjct: 237 VTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
S+ EN+ +GY ++ V+A D D NA + Y + + G+ IDPRSG + T G +
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGS-GGSPSEVFEIDPRSGVIRTRGPV 355
Query: 325 DRETQAKYQLLVTATD-GGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
DRE YQL V A+D G DP PRS TA F +Y V++ ED PG
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 383 TPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
PV+ +TA+D D+ + +HY I GN RG+F + +Q G + V PLD++ + Y L
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT--GALDVVSPLDYETTKEYTLR 473
Query: 441 VSATDSGGR----SDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
V A D GGR + + +V + + D N+ AP+F + P+ A+V E P+G VL V A D+
Sbjct: 474 VRAQD-GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
D G NA++ Y L A HD F IN TG I+ LDRE + Y V ARD
Sbjct: 533 DAGDNARLEYRL-------AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDH 585
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
G P+L+ + V ++V+DVNDN P F Q YT + EDA VGTSV V A D D + I
Sbjct: 586 GTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVI 643
Query: 617 HYEL-DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
Y++ R S G++ LD + + L A DG + T + +
Sbjct: 644 TYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVV 700
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ D N PVF+S T ++E+ P GTT+ I A D D G NA + Y ++ D F
Sbjct: 701 NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQF 758
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAP 792
++ +D + T +LDYE + Y L I A P + +EILV DVNDNAP
Sbjct: 759 RID----ADTGAVTTQAELDYED-QVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAP 813
Query: 793 VMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSM- 849
+ Y+D P ++ A D D + ++ Y G++ + + E+T +
Sbjct: 814 QFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIV 873
Query: 850 -TLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLI 887
TL NV + +V G+ + M+++V ++
Sbjct: 874 RTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVL 912
Score = 361 bits (888), Expect = 2e-98
Identities = 273/851 (32%), Positives = 414/851 (48%), Gaps = 69/851 (8%)
Query: 20 SPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAXXXX 79
+P F+ Y+A+V E +GT V +L+A D D G+ +EYT++ + N
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSN-------- 229
Query: 80 XXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVN 139
F +D +GA+ T LDRE + + V A D P R S+ AT+ +
Sbjct: 230 --------QFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMP---RRSALATLTIL 278
Query: 140 IIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII---GGNT 196
+ D ND+ P F ++ Y S+ E++ V + ++ATD D N+ I Y ++ GG+
Sbjct: 279 VTDTNDHDPVFEQQEYKESLRENLEV--GYEVLTVRATDGDAPPNANILYRLLEGSGGSP 336
Query: 197 QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQD-GGSPS-RSNTTQLLINIRDVNDNA 254
F ID SG + +D E+V SY+L + A D G P RS T + +++ D NDNA
Sbjct: 337 SEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
Query: 255 PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPR 314
P+F + V E+V G ++RV A D D+G NA + Y++ +GN +D +
Sbjct: 397 PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSI----MSGNARGQFYLDAQ 452
Query: 315 SGWVYTSGQLDRETQAKYQLLVTATDGGDPPRS-ATATXXXXXXXXXXXXXXFMPGQYEV 373
+G + LD ET +Y L V A DGG PP S + F+ ++
Sbjct: 453 TGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA 512
Query: 374 ELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGRFSITSQNGRGLITVAQPLDF 431
+ E P G V+ + A DAD DN RL Y + G F T NG G I+VA LD
Sbjct: 513 TVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG--VGHDFPFTINNGTGWISVAAELDR 570
Query: 432 KQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGTTVL 489
++ Y V A D G + TA +++T D N+ P F YT + EDA +GT+V+
Sbjct: 571 EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 630
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA--ITTNKLLDRETMSGY 547
VSA D D ++ ITY ++S + +F I Q+G ++ LD + Y
Sbjct: 631 TVSAVDRDA--HSVITYQITS-------GNTRNRFSITSQSGGGLVSLALPLDYKLERQY 681
Query: 548 LLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATD 607
+L VTA DG + DT + ++V D N + PVF+ YT N+ ED GT+V + ATD
Sbjct: 682 VLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738
Query: 608 ADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
D G N RI Y ++ + F ID +G + T LD E ++ L A D G P +
Sbjct: 739 EDTGENARITYFMEDSIPQ---FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK 795
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIK 727
S T + I + D+ND+ P F D + E+ P T++ +I A D D G N V Y+ +
Sbjct: 796 SDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ 855
Query: 728 GGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYEL---VIRAASPPLWNDVRVEIL 783
GGDD + F +E+ G + T+ LD E+ +Y L + PP + V +
Sbjct: 856 GGDDGDGDFIVESTSGIVR----TLRRLDRENV-AQYVLRAYAVDKGMPPARTPMEVTVT 910
Query: 784 VTDVNDNAPVMKDFQI-IFNNYKDCFPVG-PFGRVPAYDAD--VTDKLQYRILSGNNANL 839
V DVNDN PV + + +F ++ P+G RV A D D ++ Y+I+ GN +
Sbjct: 911 VLDVNDNPPVFEQDEFDVF--VEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEV 968
Query: 840 ILLNETTGSMT 850
L+ +G +T
Sbjct: 969 FQLDIFSGELT 979
Score = 281 bits (688), Expect = 3e-74
Identities = 203/635 (31%), Positives = 311/635 (48%), Gaps = 29/635 (4%)
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
R+VN AP+F +Q +V EN P G + ++A D DEG L YTM D + +
Sbjct: 173 RNVN-TAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM-DALFDSRSNQ 230
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++DP +G V T+ +LDRET++ + VTA D G P RSA AT F
Sbjct: 231 FFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFE 290
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDAD---EDNRLH--YEITGGNTRGRFSITSQNGRGL 422
+Y+ L E+ G V+T+ ATD D N L+ E +GG+ F I ++ G+
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRS--GV 348
Query: 423 ITVAQPLDFKQERRYVLTVSATDS----GGRSDTAMVQINITDANNYAPVFENAPYTASV 478
I P+D ++ Y LTV A+D G RS TA V +++ D N+ AP F Y V
Sbjct: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED G VL V+A+D D G NA + YS+ S + QF ++ QTGA+
Sbjct: 409 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMS-------GNARGQFYLDAQTGALDVVSP 461
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LD ET Y L V A+DGG P LS+ + V + V+D+NDN P+F + A ++E +G
Sbjct: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
V V A DAD G N R+ Y L + F I+ +G I LDRE V +
Sbjct: 522 YLVLHVQAIDADAGDNARLEYRLAGVG-HDFPFTINNGTGWISVAAELDREEVDFYSFGV 580
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTP +++ V + + D+ND+ P F T ++E++ +GT++ + A D D
Sbjct: 581 EARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD-- 638
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
++V+ Y I G+ N FS+ ++ G L + LDY+ R +Y L + A+ +
Sbjct: 639 AHSVITYQITSGNTRNRFSITSQSGGGLVSLA--LPLDYKLER-QYVLAVTASDGTRQDT 695
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNN 836
++ + VTD N + PV + N +D P G + A D D + + ++
Sbjct: 696 AQIVVNVTDANTHRPVFQSSHYTVNVNED-RPAGTTVVLISATDEDTGENARITYFMEDS 754
Query: 837 ANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
++ TG++T +L+ T+ ++ D
Sbjct: 755 IPQFRIDADTGAVTTQAELDYEDQVSYTLAITARD 789
Score = 214 bits (523), Expect = 3e-54
Identities = 155/438 (35%), Positives = 223/438 (50%), Gaps = 26/438 (5%)
Query: 464 NYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQ 523
N AP F+ Y A+V E+ P GT V + A D D G ++ Y++ + + + +Q
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRS----NQF 231
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ 583
F ++P TGA+TT + LDRET S ++ VTA+D G+P S + I V D ND++PVF+Q
Sbjct: 232 FSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQ 291
Query: 584 QLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRT 641
Q Y ++ E+ VG V V ATD D N I Y L S F IDP SGVIRT
Sbjct: 292 QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351
Query: 642 NKALDRESVATHDLKAVAIDGGTP--PQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
+DRE V ++ L A D G P+S+T V + +ED ND+ P F + E+
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED 411
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
G + + A D D+G NAVVHYSI G+ F L+ + G+ L + LDYE+
Sbjct: 412 VTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDYET- 466
Query: 760 RKKYELVIRA---ASPPLWN-DVRVEILVTDVNDNAP--VMKDFQIIFNNYKDCFPVGPF 813
K+Y L +RA PPL N V + V D+NDNAP V FQ + P+G
Sbjct: 467 TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA---TVLESVPLGYL 523
Query: 814 G-RVPAYDADVTD--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVT 870
V A DAD D +L+YR+ + +N TG ++++ +L+ + V
Sbjct: 524 VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
Query: 871 D-GVNEIKAMMQLSVRLI 887
D G + A +SV ++
Sbjct: 584 DHGTPALTASASVSVTVL 601
Score = 125 bits (301), Expect = 3e-27
Identities = 104/337 (30%), Positives = 159/337 (47%), Gaps = 38/337 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P F Y+ SV E T+VL + ATD+D G N V YT +
Sbjct: 802 EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ------ 855
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D F ++ SG + T LDRE VA+Y + A D+ P +
Sbjct: 856 -GGDDGDGD-----------FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPA-- 901
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+ + V ++D NDN P F + + V V+E+ + +A++ ATD D G N+ I Y
Sbjct: 902 -RTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI--GLAVARVTATDPDEGTNAQIMY 958
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
I+ GN F +D SG+++ + LDYE Y LVI+A SR+ + + + D
Sbjct: 959 QIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRAT---VHVRLLD 1015
Query: 250 VNDNAPRF--YTSLFQESV---SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
NDN P + LF V S + P G +I RV A+D D ++ LTY+ GN
Sbjct: 1016 RNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPD--ISDSLTYSFE----RGN 1068
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG 341
+ ++ +G + S LD + + V +DG
Sbjct: 1069 ELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
Score = 54.8 bits (126), Expect = 4e-06
Identities = 45/148 (30%), Positives = 79/148 (53%), Gaps = 18/148 (12%)
Query: 2176 LKKPIRLQIWLDINRETFGSRTNPQCVHWS---TLRGSGEWSRVGCHTEIDYDWSPYSEE 2232
L KP+ +Q L E RT P CV W+ + G+G WS GC E+ + +
Sbjct: 2298 LDKPVTVQFRLLETEE----RTKPICVFWNHSILVSGTGGWSARGC--EVVFRNESH--- 2348
Query: 2233 PLLINCTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCLIRG 2292
++C CNH+++FAVL+D V E L+++T Y A ++L LL ++ L L+R
Sbjct: 2349 ---VSCQCNHMTSFAVLMD-VSRRENGEILPLKTLT-YVALGVTLAALLLTFFFLTLLR- 2402
Query: 2293 GAATVSNSIHKHLIFSVFMAELLYLIAL 2320
+ + I ++L ++ +A+L++L+ +
Sbjct: 2403 ILRSNQHGIRRNLTAALGLAQLVFLLGI 2430
Score = 37.5 bits (83), Expect = 0.69
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 6/76 (7%)
Query: 1509 DGCQSRAD-CMLSICPPYSKCVTSWDSSTCTCEAGRVGPQC-VSA----CELGPCGAARC 1562
D C++ D C C P+ +C + TC C G G C VSA C G C
Sbjct: 1283 DYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGT 1342
Query: 1563 VPDQTPKGYSCACEPG 1578
+ G+ C C G
Sbjct: 1343 CVNLLVGGFKCDCPSG 1358
Score = 35.1 bits (77), Expect = 3.7
Identities = 32/96 (33%), Positives = 36/96 (37%), Gaps = 17/96 (17%)
Query: 1537 CTCEAGRVGPQC---VSACELGPCGA-ARCVPDQTPKGYSCACEPGYTLTTSGCIESGKE 1592
C C G G C V C PCG RC + GY+C C GY T C S +
Sbjct: 1274 CRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREG--GYTCLCRDGY--TGEHCEVSARS 1329
Query: 1593 -EC-PGGWWGGSAC-----GPCACDVTRG--YHPHC 1619
C PG G C G CD G P+C
Sbjct: 1330 GRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYC 1365
Score = 33.9 bits (74), Expect = 8.5
Identities = 13/39 (33%), Positives = 18/39 (46%)
Query: 1310 CPEKRSRCSSAPCYNGAECSDLWDTYICDCKEGHTGKDC 1348
C + C S PC C Y C C++G+TG+ C
Sbjct: 1285 CETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHC 1323
>AF234887-1|AAG00080.1| 2923|Homo sapiens FLAMINGO 1 protein.
Length = 2923
Score = 901 bits (2230), Expect = 0.0
Identities = 492/1105 (44%), Positives = 668/1105 (60%), Gaps = 58/1105 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D NDH PVFE Q+Y+ S+RE G VLT++ATD D NA + Y L+
Sbjct: 277 ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILY--RLLEGSGG 334
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+P + VF ID RSG + TR +DRE+V Y + V+A+DQ R
Sbjct: 335 SPSE--------------VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPR- 379
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+TA + +++ DDNDN PQFSEK Y V V ED VT + ++ A+D D G+N+ + Y+
Sbjct: 380 STTAAVFLSVEDDNDNAPQFSEKRYVVQVRED--VTPGAPVLRVTASDRDKGSNAVVHYS 437
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRD 249
I+ GN + QF +D+ +G + +V LDYE + Y L +RAQDGG P SN + L+ + + D
Sbjct: 438 IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLD 497
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
+NDNAP F ++ FQ +V E+VP+GY ++ VQA DAD G NA L Y + + D P
Sbjct: 498 INDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGH----DFPF 553
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
TI+ +GW+ + +LDRE Y V A D G P +A+A+ F
Sbjct: 554 TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQP 613
Query: 370 QYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPL 429
+Y V L ED GT VVT++A D D + + Y+IT GNTR RFSITSQ+G GL+++A PL
Sbjct: 614 EYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPL 673
Query: 430 DFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
D+K ER+YVL V+A+D G R DTA + +N+TDAN + PVF+++ YT +V ED P GTTV+
Sbjct: 674 DYKLERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 732
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
++SATD D G NA+ITY + I QF I+ TGA+TT LD E Y L
Sbjct: 733 LISATDEDTGENARITYFMEDSIP---------QFRIDADTGAVTTQAELDYEDQVSYTL 783
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
+TARD G+P SDTT +EI V DVNDN P F + Y ++ ED TSV Q+ ATD D
Sbjct: 784 AITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GLNGR+ Y D +G F+++ SG++RT + LDRE+VA + L+A A+D G PP +
Sbjct: 844 SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPART 903
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
+ V + + D+ND+PPVFE D ++ ENSPIG + + A DPDEG NA + Y I G
Sbjct: 904 PMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEG 963
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVND 789
+ F L+ G EL +VDLDYE R +Y LVI+A S PL + V + + D ND
Sbjct: 964 NIPEVFQLDIFSG----ELTALVDLDYED-RPEYVLVIQATSAPLVSRATVHVRLLDRND 1018
Query: 790 NAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNET 845
N PV+ +F+I+FNNY FP G GRVPA+D D++D L Y GN +L+LLN +
Sbjct: 1019 NPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAS 1078
Query: 846 TGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTA 905
TG + LS L+ N P A M V V+DGV+ + A L V +IT+EML +SIT+RL DM+
Sbjct: 1079 TGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSP 1138
Query: 906 EQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVT-GNILNVSFSARRPDAEVGVAG 964
E+FLSPLLG FI +AA + P +++ +F+VQ DTD G+ILNVS S +P G G
Sbjct: 1139 ERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPP---GPGG 1195
Query: 965 DPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEECLTVLKFGNASG 1024
P P L+ER+YL+R+ L ++ +VLPFDDNIC+ EPC N+ C++VL+F +++
Sbjct: 1196 GP-PFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAP 1254
Query: 1025 FVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARRE 1084
F+ S SVLFRPI+PV C+CP GFTG CET + G CRS RE
Sbjct: 1255 FIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRS-------RE 1307
Query: 1085 GGILCQGCSIDAAYTTAVCELRARS 1109
GG C C YT CE+ ARS
Sbjct: 1308 GGYTCL-CR--DGYTGEHCEVSARS 1329
Score = 626 bits (1547), Expect = e-178
Identities = 337/941 (35%), Positives = 499/941 (53%), Gaps = 82/941 (8%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC C +G+TG +CE C +C++G CV GG C S D +
Sbjct: 1310 YTCLCRDGYTGEHCEVSARSGRCTP----GVCKNGGTCVNLLVGGFKCDCPSGD--FEKP 1363
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
C++ RSFP SF+TF GL++R L L FAT+ GLLLYNGR+NE+HDF+ALE++
Sbjct: 1364 YCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQ 1423
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEIT--VEGNVGDGSWHTVEIEYFNRTI----------- 1208
+ ++ +FS G + ++ V G V DG WHTV+++Y+N+ +
Sbjct: 1424 EQ--------VQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPS 1475
Query: 1209 -----TMILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTETCHRFLDLTGPLQ 1263
+ +D CD ++L + G Y+CA + + LDLTGPL
Sbjct: 1476 EQKVAVVTVDGCDTGVALRFGSVLG-NYSCA----------AQGTQGGSKKSLDLTGPLL 1524
Query: 1264 IGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPCY 1323
+GG+P++P SF V+ + FVGC+ + +D + ID+ ++A+NGT+ GCP K++ C S C+
Sbjct: 1525 LGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCH 1584
Query: 1324 NGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFNPLLRPIQLPWLNALSI 1383
NG C + WD + C+C G GK CA P F G +++++ L PI PW +L
Sbjct: 1585 NGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMF 1644
Query: 1384 RTRQRDAFVM----------SIQLKSGLLHYSYNG-----ETMYLPMATLSDGAWHRIEI 1428
RTRQ D ++ ++QL+ G + S G ++ L +DG WH ++
Sbjct: 1645 RTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQL 1704
Query: 1429 KWLGTD-----ISVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDVGFFE 1483
LG ++ DYG + L ++ G ++ I +GG+ AG +A F
Sbjct: 1705 A-LGASGGPGHAILSFDYGQQRA-EGNLGPRLHGLHLSNITVGGIPGPAGGVARG---FR 1759
Query: 1484 GCIQDVRIGTAQSLLNR--PTVRE--NVRDGCQSRADCMLSICPPYSKCVTSWDSSTCTC 1539
GC+Q VR+ +N P+ E NV GC C + CP S C WDS +C+C
Sbjct: 1760 GCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSC 1819
Query: 1540 EAGRVGPQCVSACELGPCG-AARCV-PDQTPKGYSCACEPGYTLTTSGCIESGKEECPGG 1597
+ G G C + C+L PC + C P GY+C C P Y C + CP G
Sbjct: 1820 DPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYL--GPYCETRIDQPCPRG 1877
Query: 1598 WWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSENSSCE 1657
WWG CGPC CDV++G+ P CNK +G+CHCKENHY+P G+ CL C CY GS + C+
Sbjct: 1878 WWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCD 1937
Query: 1658 AATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFGVETI 1717
GQC C+PGVIGR CD C N +AEVT N GCEV YD CPR+ G+WWPRT+FG+
Sbjct: 1938 PEDGQCPCKPGVIGRQCDRCDNPFAEVTTN-GCEVNYDSCPRAIEAGIWWPRTRFGLPAA 1996
Query: 1718 TDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTFVGVR 1777
CP GS G A R CDE + W P++FNCT+ TF +L+ +++ E +++ +
Sbjct: 1997 APCPKGSFGTAVRHCDEHRG--WLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQ 2054
Query: 1778 VAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLKSTNT 1837
+A L A +T +G+DV VA + L+ +E Q G L+ +QD + NLL+ +
Sbjct: 2055 LALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSA 2114
Query: 1838 ILNVEYEREWKRIRELTGHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKDVVISVDT 1897
+L+ +R W+ I++ G G L+Q ++ Y + LA++ TY SPF IVT ++VISV
Sbjct: 2115 LLDTANKRHWELIQQTEG-GTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVR 2173
Query: 1898 VTSESIYGFEPTQLNRLNVDS-YTTERVVALPDTSAFIHSP 1937
+ + G + + L + E V LP+ S F +P
Sbjct: 2174 LDKGNFAGAKLPRYEALRGEQPPDLETTVILPE-SVFRETP 2213
Score = 363 bits (892), Expect = 6e-99
Identities = 253/759 (33%), Positives = 374/759 (49%), Gaps = 44/759 (5%)
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY---AIIGGNTQMQFSIDS 204
PQF +Y +V E+ PV A ++A D D G + Y A+ + FS+D
Sbjct: 179 PQFQPPSYQATVPEN-QPAGTPV-ASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDP 236
Query: 205 LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++G V+ + LD E ++ + AQD G P RS L I + D ND+ P F ++E
Sbjct: 237 VTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
S+ EN+ +GY ++ V+A D D NA + Y + + G+ IDPRSG + T G +
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGS-GGSPSEVFEIDPRSGVIRTRGPV 355
Query: 325 DRETQAKYQLLVTATD-GGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
DRE YQL V A+D G DP PRS TA F +Y V++ ED PG
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 383 TPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
PV+ +TA+D D+ + +HY I GN RG+F + +Q G + V PLD++ + Y L
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT--GALDVVSPLDYETTKEYTLR 473
Query: 441 VSATDSGGR----SDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
V A D GGR + + +V + + D N+ AP+F + P+ A+V E P+G VL V A D+
Sbjct: 474 VRAQD-GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
D G NA++ Y L A HD F IN TG I+ LDRE + Y V ARD
Sbjct: 533 DAGDNARLEYRL-------AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDH 585
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
G P+L+ + V ++V+DVNDN P F Q YT + EDA VGTSV V A D D + I
Sbjct: 586 GTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVI 643
Query: 617 HYEL-DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
Y++ R S G++ LD + + L A DG + T + +
Sbjct: 644 TYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVV 700
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ D N PVF+S T ++E+ P GTT+ I A D D G NA + Y ++ D F
Sbjct: 701 NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQF 758
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAP 792
++ +D + T +LDYE + Y L I A P + +EILV DVNDNAP
Sbjct: 759 RID----ADTGAVTTQAELDYED-QVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAP 813
Query: 793 VMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSM- 849
+ Y+D P ++ A D D + ++ Y G++ + + E+T +
Sbjct: 814 QFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIV 873
Query: 850 -TLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLI 887
TL NV + +V G+ + M+++V ++
Sbjct: 874 RTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVL 912
Score = 361 bits (888), Expect = 2e-98
Identities = 273/851 (32%), Positives = 414/851 (48%), Gaps = 69/851 (8%)
Query: 20 SPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAXXXX 79
+P F+ Y+A+V E +GT V +L+A D D G+ +EYT++ + N
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSN-------- 229
Query: 80 XXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVN 139
F +D +GA+ T LDRE + + V A D P R S+ AT+ +
Sbjct: 230 --------QFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMP---RRSALATLTIL 278
Query: 140 IIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII---GGNT 196
+ D ND+ P F ++ Y S+ E++ V + ++ATD D N+ I Y ++ GG+
Sbjct: 279 VTDTNDHDPVFEQQEYKESLRENLEV--GYEVLTVRATDGDAPPNANILYRLLEGSGGSP 336
Query: 197 QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQD-GGSPS-RSNTTQLLINIRDVNDNA 254
F ID SG + +D E+V SY+L + A D G P RS T + +++ D NDNA
Sbjct: 337 SEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
Query: 255 PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPR 314
P+F + V E+V G ++RV A D D+G NA + Y++ +GN +D +
Sbjct: 397 PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSI----MSGNARGQFYLDAQ 452
Query: 315 SGWVYTSGQLDRETQAKYQLLVTATDGGDPPRS-ATATXXXXXXXXXXXXXXFMPGQYEV 373
+G + LD ET +Y L V A DGG PP S + F+ ++
Sbjct: 453 TGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA 512
Query: 374 ELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGRFSITSQNGRGLITVAQPLDF 431
+ E P G V+ + A DAD DN RL Y + G F T NG G I+VA LD
Sbjct: 513 TVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG--VGHDFPFTINNGTGWISVAAELDR 570
Query: 432 KQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGTTVL 489
++ Y V A D G + TA +++T D N+ P F YT + EDA +GT+V+
Sbjct: 571 EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 630
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA--ITTNKLLDRETMSGY 547
VSA D D ++ ITY ++S + +F I Q+G ++ LD + Y
Sbjct: 631 TVSAVDRDA--HSVITYQITS-------GNTRNRFSITSQSGGGLVSLALPLDYKLERQY 681
Query: 548 LLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATD 607
+L VTA DG + DT + ++V D N + PVF+ YT N+ ED GT+V + ATD
Sbjct: 682 VLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738
Query: 608 ADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
D G N RI Y ++ + F ID +G + T LD E ++ L A D G P +
Sbjct: 739 EDTGENARITYFMEDSIPQ---FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK 795
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIK 727
S T + I + D+ND+ P F D + E+ P T++ +I A D D G N V Y+ +
Sbjct: 796 SDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ 855
Query: 728 GGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYEL---VIRAASPPLWNDVRVEIL 783
GGDD + F +E+ G + T+ LD E+ +Y L + PP + V +
Sbjct: 856 GGDDGDGDFIVESTSGIVR----TLRRLDRENV-AQYVLRAYAVDKGMPPARTPMEVTVT 910
Query: 784 VTDVNDNAPVMKDFQI-IFNNYKDCFPVG-PFGRVPAYDAD--VTDKLQYRILSGNNANL 839
V DVNDN PV + + +F ++ P+G RV A D D ++ Y+I+ GN +
Sbjct: 911 VLDVNDNPPVFEQDEFDVF--VEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEV 968
Query: 840 ILLNETTGSMT 850
L+ +G +T
Sbjct: 969 FQLDIFSGELT 979
Score = 281 bits (688), Expect = 3e-74
Identities = 203/635 (31%), Positives = 311/635 (48%), Gaps = 29/635 (4%)
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
R+VN AP+F +Q +V EN P G + ++A D DEG L YTM D + +
Sbjct: 173 RNVN-TAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM-DALFDSRSNQ 230
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++DP +G V T+ +LDRET++ + VTA D G P RSA AT F
Sbjct: 231 FFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFE 290
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDAD---EDNRLH--YEITGGNTRGRFSITSQNGRGL 422
+Y+ L E+ G V+T+ ATD D N L+ E +GG+ F I ++ G+
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRS--GV 348
Query: 423 ITVAQPLDFKQERRYVLTVSATDS----GGRSDTAMVQINITDANNYAPVFENAPYTASV 478
I P+D ++ Y LTV A+D G RS TA V +++ D N+ AP F Y V
Sbjct: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED G VL V+A+D D G NA + YS+ S + QF ++ QTGA+
Sbjct: 409 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMS-------GNARGQFYLDAQTGALDVVSP 461
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LD ET Y L V A+DGG P LS+ + V + V+D+NDN P+F + A ++E +G
Sbjct: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
V V A DAD G N R+ Y L + F I+ +G I LDRE V +
Sbjct: 522 YLVLHVQAIDADAGDNARLEYRLAGVG-HDFPFTINNGTGWISVAAELDREEVDFYSFGV 580
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTP +++ V + + D+ND+ P F T ++E++ +GT++ + A D D
Sbjct: 581 EARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD-- 638
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
++V+ Y I G+ N FS+ ++ G L + LDY+ R +Y L + A+ +
Sbjct: 639 AHSVITYQITSGNTRNRFSITSQSGGGLVSLA--LPLDYKLER-QYVLAVTASDGTRQDT 695
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNN 836
++ + VTD N + PV + N +D P G + A D D + + ++
Sbjct: 696 AQIVVNVTDANTHRPVFQSSHYTVNVNED-RPAGTTVVLISATDEDTGENARITYFMEDS 754
Query: 837 ANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
++ TG++T +L+ T+ ++ D
Sbjct: 755 IPQFRIDADTGAVTTQAELDYEDQVSYTLAITARD 789
Score = 214 bits (523), Expect = 3e-54
Identities = 155/438 (35%), Positives = 223/438 (50%), Gaps = 26/438 (5%)
Query: 464 NYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQ 523
N AP F+ Y A+V E+ P GT V + A D D G ++ Y++ + + + +Q
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRS----NQF 231
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ 583
F ++P TGA+TT + LDRET S ++ VTA+D G+P S + I V D ND++PVF+Q
Sbjct: 232 FSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQ 291
Query: 584 QLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRT 641
Q Y ++ E+ VG V V ATD D N I Y L S F IDP SGVIRT
Sbjct: 292 QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351
Query: 642 NKALDRESVATHDLKAVAIDGGTP--PQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
+DRE V ++ L A D G P+S+T V + +ED ND+ P F + E+
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED 411
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
G + + A D D+G NAVVHYSI G+ F L+ + G+ L + LDYE+
Sbjct: 412 VTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDYET- 466
Query: 760 RKKYELVIRA---ASPPLWN-DVRVEILVTDVNDNAP--VMKDFQIIFNNYKDCFPVGPF 813
K+Y L +RA PPL N V + V D+NDNAP V FQ + P+G
Sbjct: 467 TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA---TVLESVPLGYL 523
Query: 814 G-RVPAYDADVTD--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVT 870
V A DAD D +L+YR+ + +N TG ++++ +L+ + V
Sbjct: 524 VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
Query: 871 D-GVNEIKAMMQLSVRLI 887
D G + A +SV ++
Sbjct: 584 DHGTPALTASASVSVTVL 601
Score = 125 bits (301), Expect = 3e-27
Identities = 104/337 (30%), Positives = 159/337 (47%), Gaps = 38/337 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P F Y+ SV E T+VL + ATD+D G N V YT +
Sbjct: 802 EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ------ 855
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D F ++ SG + T LDRE VA+Y + A D+ P +
Sbjct: 856 -GGDDGDGD-----------FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPA-- 901
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+ + V ++D NDN P F + + V V+E+ + +A++ ATD D G N+ I Y
Sbjct: 902 -RTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI--GLAVARVTATDPDEGTNAQIMY 958
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
I+ GN F +D SG+++ + LDYE Y LVI+A SR+ + + + D
Sbjct: 959 QIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRAT---VHVRLLD 1015
Query: 250 VNDNAPRF--YTSLFQESV---SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
NDN P + LF V S + P G +I RV A+D D ++ LTY+ GN
Sbjct: 1016 RNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPD--ISDSLTYSFE----RGN 1068
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG 341
+ ++ +G + S LD + + V +DG
Sbjct: 1069 ELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
Score = 54.8 bits (126), Expect = 4e-06
Identities = 45/148 (30%), Positives = 79/148 (53%), Gaps = 18/148 (12%)
Query: 2176 LKKPIRLQIWLDINRETFGSRTNPQCVHWS---TLRGSGEWSRVGCHTEIDYDWSPYSEE 2232
L KP+ +Q L E RT P CV W+ + G+G WS GC E+ + +
Sbjct: 2298 LDKPVTVQFRLLETEE----RTKPICVFWNHSILVSGTGGWSARGC--EVVFRNESH--- 2348
Query: 2233 PLLINCTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCLIRG 2292
++C CNH+++FAVL+D V E L+++T Y A ++L LL ++ L L+R
Sbjct: 2349 ---VSCQCNHMTSFAVLMD-VSRRENGEILPLKTLT-YVALGVTLAALLLTFFFLTLLR- 2402
Query: 2293 GAATVSNSIHKHLIFSVFMAELLYLIAL 2320
+ + I ++L ++ +A+L++L+ +
Sbjct: 2403 ILRSNQHGIRRNLTAALGLAQLVFLLGI 2430
Score = 37.5 bits (83), Expect = 0.69
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 6/76 (7%)
Query: 1509 DGCQSRAD-CMLSICPPYSKCVTSWDSSTCTCEAGRVGPQC-VSA----CELGPCGAARC 1562
D C++ D C C P+ +C + TC C G G C VSA C G C
Sbjct: 1283 DYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGT 1342
Query: 1563 VPDQTPKGYSCACEPG 1578
+ G+ C C G
Sbjct: 1343 CVNLLVGGFKCDCPSG 1358
Score = 35.1 bits (77), Expect = 3.7
Identities = 32/96 (33%), Positives = 36/96 (37%), Gaps = 17/96 (17%)
Query: 1537 CTCEAGRVGPQC---VSACELGPCGA-ARCVPDQTPKGYSCACEPGYTLTTSGCIESGKE 1592
C C G G C V C PCG RC + GY+C C GY T C S +
Sbjct: 1274 CRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREG--GYTCLCRDGY--TGEHCEVSARS 1329
Query: 1593 -EC-PGGWWGGSAC-----GPCACDVTRG--YHPHC 1619
C PG G C G CD G P+C
Sbjct: 1330 GRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYC 1365
Score = 33.9 bits (74), Expect = 8.5
Identities = 13/39 (33%), Positives = 18/39 (46%)
Query: 1310 CPEKRSRCSSAPCYNGAECSDLWDTYICDCKEGHTGKDC 1348
C + C S PC C Y C C++G+TG+ C
Sbjct: 1285 CETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHC 1323
>AB065955-1|BAC06168.1| 2923|Homo sapiens seven transmembrane helix
receptor protein.
Length = 2923
Score = 901 bits (2230), Expect = 0.0
Identities = 492/1105 (44%), Positives = 668/1105 (60%), Gaps = 58/1105 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D NDH PVFE Q+Y+ S+RE G VLT++ATD D NA + Y L+
Sbjct: 277 ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILY--RLLEGSGG 334
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+P + VF ID RSG + TR +DRE+V Y + V+A+DQ R
Sbjct: 335 SPSE--------------VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPR- 379
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+TA + +++ DDNDN PQFSEK Y V V ED VT + ++ A+D D G+N+ + Y+
Sbjct: 380 STTAAVFLSVEDDNDNAPQFSEKRYVVQVRED--VTPGAPVLRVTASDRDKGSNAVVHYS 437
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRD 249
I+ GN + QF +D+ +G + +V LDYE + Y L +RAQDGG P SN + L+ + + D
Sbjct: 438 IMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLD 497
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
+NDNAP F ++ FQ +V E+VP+GY ++ VQA DAD G NA L Y + + D P
Sbjct: 498 INDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGH----DFPF 553
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
TI+ +GW+ + +LDRE Y V A D G P +A+A+ F
Sbjct: 554 TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQP 613
Query: 370 QYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPL 429
+Y V L ED GT VVT++A D D + + Y+IT GNTR RFSITSQ+G GL+++A PL
Sbjct: 614 EYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPL 673
Query: 430 DFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
D+K ER+YVL V+A+D G R DTA + +N+TDAN + PVF+++ YT +V ED P GTTV+
Sbjct: 674 DYKLERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 732
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
++SATD D G NA+ITY + I QF I+ TGA+TT LD E Y L
Sbjct: 733 LISATDEDTGENARITYFMEDSIP---------QFRIDADTGAVTTQAELDYEDQVSYTL 783
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
+TARD G+P SDTT +EI V DVNDN P F + Y ++ ED TSV Q+ ATD D
Sbjct: 784 AITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GLNGR+ Y D +G F+++ SG++RT + LDRE+VA + L+A A+D G PP +
Sbjct: 844 SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPART 903
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
+ V + + D+ND+PPVFE D ++ ENSPIG + + A DPDEG NA + Y I G
Sbjct: 904 PMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEG 963
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVND 789
+ F L+ G EL +VDLDYE R +Y LVI+A S PL + V + + D ND
Sbjct: 964 NIPEVFQLDIFSG----ELTALVDLDYED-RPEYVLVIQATSAPLVSRATVHVRLLDRND 1018
Query: 790 NAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNET 845
N PV+ +F+I+FNNY FP G GRVPA+D D++D L Y GN +L+LLN +
Sbjct: 1019 NPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAS 1078
Query: 846 TGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTA 905
TG + LS L+ N P A M V V+DGV+ + A L V +IT+EML +SIT+RL DM+
Sbjct: 1079 TGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSP 1138
Query: 906 EQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVT-GNILNVSFSARRPDAEVGVAG 964
E+FLSPLLG FI +AA + P +++ +F+VQ DTD G+ILNVS S +P G G
Sbjct: 1139 ERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPP---GPGG 1195
Query: 965 DPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEECLTVLKFGNASG 1024
P P L+ER+YL+R+ L ++ +VLPFDDNIC+ EPC N+ C++VL+F +++
Sbjct: 1196 GP-PFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAP 1254
Query: 1025 FVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARRE 1084
F+ S SVLFRPI+PV C+CP GFTG CET + G CRS RE
Sbjct: 1255 FIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRS-------RE 1307
Query: 1085 GGILCQGCSIDAAYTTAVCELRARS 1109
GG C C YT CE+ ARS
Sbjct: 1308 GGYTCL-CR--DGYTGEHCEVSARS 1329
Score = 626 bits (1547), Expect = e-178
Identities = 337/941 (35%), Positives = 499/941 (53%), Gaps = 82/941 (8%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+TC C +G+TG +CE C +C++G CV GG C S D +
Sbjct: 1310 YTCLCRDGYTGEHCEVSARSGRCTP----GVCKNGGTCVNLLVGGFKCDCPSGD--FEKP 1363
Query: 1102 VCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELVS 1161
C++ RSFP SF+TF GL++R L L FAT+ GLLLYNGR+NE+HDF+ALE++
Sbjct: 1364 YCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQ 1423
Query: 1162 SEAGRGGGPGLRFSFSLGGGKSEIT--VEGNVGDGSWHTVEIEYFNRTI----------- 1208
+ ++ +FS G + ++ V G V DG WHTV+++Y+N+ +
Sbjct: 1424 EQ--------VQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPS 1475
Query: 1209 -----TMILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTETCHRFLDLTGPLQ 1263
+ +D CD ++L + G Y+CA + + LDLTGPL
Sbjct: 1476 EQKVAVVTVDGCDTGVALRFGSVLG-NYSCA----------AQGTQGGSKKSLDLTGPLL 1524
Query: 1264 IGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPCY 1323
+GG+P++P SF V+ + FVGC+ + +D + ID+ ++A+NGT+ GCP K++ C S C+
Sbjct: 1525 LGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCH 1584
Query: 1324 NGAECSDLWDTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFNPLLRPIQLPWLNALSI 1383
NG C + WD + C+C G GK CA P F G +++++ L PI PW +L
Sbjct: 1585 NGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMF 1644
Query: 1384 RTRQRDAFVM----------SIQLKSGLLHYSYNG-----ETMYLPMATLSDGAWHRIEI 1428
RTRQ D ++ ++QL+ G + S G ++ L +DG WH ++
Sbjct: 1645 RTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQL 1704
Query: 1429 KWLGTD-----ISVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDVGFFE 1483
LG ++ DYG + L ++ G ++ I +GG+ AG +A F
Sbjct: 1705 A-LGASGGPGHAILSFDYGQQRA-EGNLGPRLHGLHLSNITVGGIPGPAGGVARG---FR 1759
Query: 1484 GCIQDVRIGTAQSLLNR--PTVRE--NVRDGCQSRADCMLSICPPYSKCVTSWDSSTCTC 1539
GC+Q VR+ +N P+ E NV GC C + CP S C WDS +C+C
Sbjct: 1760 GCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSC 1819
Query: 1540 EAGRVGPQCVSACELGPCG-AARCV-PDQTPKGYSCACEPGYTLTTSGCIESGKEECPGG 1597
+ G G C + C+L PC + C P GY+C C P Y C + CP G
Sbjct: 1820 DPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYL--GPYCETRIDQPCPRG 1877
Query: 1598 WWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGTAECLPCQCYAAGSENSSCE 1657
WWG CGPC CDV++G+ P CNK +G+CHCKENHY+P G+ CL C CY GS + C+
Sbjct: 1878 WWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCD 1937
Query: 1658 AATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCPRSFAGGVWWPRTKFGVETI 1717
GQC C+PGVIGR CD C N +AEVT N GCEV YD CPR+ G+WWPRT+FG+
Sbjct: 1938 PEDGQCPCKPGVIGRQCDRCDNPFAEVTTN-GCEVNYDSCPRAIEAGIWWPRTRFGLPAA 1996
Query: 1718 TDCPPGSSGRATRTCDETKDVPWQDPDMFNCTTATFYQLRKQLHKIETGELTMNTFVGVR 1777
CP GS G A R CDE + W P++FNCT+ TF +L+ +++ E +++ +
Sbjct: 1997 APCPKGSFGTAVRHCDEHRG--WLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQ 2054
Query: 1778 VAADLSTACANTPRLYGADVVVAEGILLELMDYELRQAGLNLTHSQDKDYVRNLLKSTNT 1837
+A L A +T +G+DV VA + L+ +E Q G L+ +QD + NLL+ +
Sbjct: 2055 LALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSA 2114
Query: 1838 ILNVEYEREWKRIRELTGHGAELLVQKFDEYIAVLAESQHDTYTSPFEIVTKDVVISVDT 1897
+L+ +R W+ I++ G G L+Q ++ Y + LA++ TY SPF IVT ++VISV
Sbjct: 2115 LLDTANKRHWELIQQTEG-GTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVR 2173
Query: 1898 VTSESIYGFEPTQLNRLNVDS-YTTERVVALPDTSAFIHSP 1937
+ + G + + L + E V LP+ S F +P
Sbjct: 2174 LDKGNFAGAKLPRYEALRGEQPPDLETTVILPE-SVFRETP 2213
Score = 363 bits (892), Expect = 6e-99
Identities = 253/759 (33%), Positives = 374/759 (49%), Gaps = 44/759 (5%)
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY---AIIGGNTQMQFSIDS 204
PQF +Y +V E+ PV A ++A D D G + Y A+ + FS+D
Sbjct: 179 PQFQPPSYQATVPEN-QPAGTPV-ASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDP 236
Query: 205 LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++G V+ + LD E ++ + AQD G P RS L I + D ND+ P F ++E
Sbjct: 237 VTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
S+ EN+ +GY ++ V+A D D NA + Y + + G+ IDPRSG + T G +
Sbjct: 297 SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGS-GGSPSEVFEIDPRSGVIRTRGPV 355
Query: 325 DRETQAKYQLLVTATD-GGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
DRE YQL V A+D G DP PRS TA F +Y V++ ED PG
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 383 TPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
PV+ +TA+D D+ + +HY I GN RG+F + +Q G + V PLD++ + Y L
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT--GALDVVSPLDYETTKEYTLR 473
Query: 441 VSATDSGGR----SDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
V A D GGR + + +V + + D N+ AP+F + P+ A+V E P+G VL V A D+
Sbjct: 474 VRAQD-GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDA 532
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
D G NA++ Y L A HD F IN TG I+ LDRE + Y V ARD
Sbjct: 533 DAGDNARLEYRL-------AGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDH 585
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
G P+L+ + V ++V+DVNDN P F Q YT + EDA VGTSV V A D D + I
Sbjct: 586 GTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVI 643
Query: 617 HYEL-DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
Y++ R S G++ LD + + L A DG + T + +
Sbjct: 644 TYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVV 700
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ D N PVF+S T ++E+ P GTT+ I A D D G NA + Y ++ D F
Sbjct: 701 NVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQF 758
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAP 792
++ +D + T +LDYE + Y L I A P + +EILV DVNDNAP
Sbjct: 759 RID----ADTGAVTTQAELDYED-QVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAP 813
Query: 793 VMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSM- 849
+ Y+D P ++ A D D + ++ Y G++ + + E+T +
Sbjct: 814 QFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIV 873
Query: 850 -TLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLI 887
TL NV + +V G+ + M+++V ++
Sbjct: 874 RTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVL 912
Score = 361 bits (888), Expect = 2e-98
Identities = 273/851 (32%), Positives = 414/851 (48%), Gaps = 69/851 (8%)
Query: 20 SPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAXXXX 79
+P F+ Y+A+V E +GT V +L+A D D G+ +EYT++ + N
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSN-------- 229
Query: 80 XXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVN 139
F +D +GA+ T LDRE + + V A D P R S+ AT+ +
Sbjct: 230 --------QFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMP---RRSALATLTIL 278
Query: 140 IIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII---GGNT 196
+ D ND+ P F ++ Y S+ E++ V + ++ATD D N+ I Y ++ GG+
Sbjct: 279 VTDTNDHDPVFEQQEYKESLRENLEV--GYEVLTVRATDGDAPPNANILYRLLEGSGGSP 336
Query: 197 QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQD-GGSPS-RSNTTQLLINIRDVNDNA 254
F ID SG + +D E+V SY+L + A D G P RS T + +++ D NDNA
Sbjct: 337 SEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNA 396
Query: 255 PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPR 314
P+F + V E+V G ++RV A D D+G NA + Y++ +GN +D +
Sbjct: 397 PQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSI----MSGNARGQFYLDAQ 452
Query: 315 SGWVYTSGQLDRETQAKYQLLVTATDGGDPPRS-ATATXXXXXXXXXXXXXXFMPGQYEV 373
+G + LD ET +Y L V A DGG PP S + F+ ++
Sbjct: 453 TGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA 512
Query: 374 ELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGRFSITSQNGRGLITVAQPLDF 431
+ E P G V+ + A DAD DN RL Y + G F T NG G I+VA LD
Sbjct: 513 TVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG--VGHDFPFTINNGTGWISVAAELDR 570
Query: 432 KQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGTTVL 489
++ Y V A D G + TA +++T D N+ P F YT + EDA +GT+V+
Sbjct: 571 EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 630
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA--ITTNKLLDRETMSGY 547
VSA D D ++ ITY ++S + +F I Q+G ++ LD + Y
Sbjct: 631 TVSAVDRDA--HSVITYQITS-------GNTRNRFSITSQSGGGLVSLALPLDYKLERQY 681
Query: 548 LLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATD 607
+L VTA DG + DT + ++V D N + PVF+ YT N+ ED GT+V + ATD
Sbjct: 682 VLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738
Query: 608 ADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
D G N RI Y ++ + F ID +G + T LD E ++ L A D G P +
Sbjct: 739 EDTGENARITYFMEDSIPQ---FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQK 795
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIK 727
S T + I + D+ND+ P F D + E+ P T++ +I A D D G N V Y+ +
Sbjct: 796 SDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ 855
Query: 728 GGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYEL---VIRAASPPLWNDVRVEIL 783
GGDD + F +E+ G + T+ LD E+ +Y L + PP + V +
Sbjct: 856 GGDDGDGDFIVESTSGIVR----TLRRLDRENV-AQYVLRAYAVDKGMPPARTPMEVTVT 910
Query: 784 VTDVNDNAPVMKDFQI-IFNNYKDCFPVG-PFGRVPAYDAD--VTDKLQYRILSGNNANL 839
V DVNDN PV + + +F ++ P+G RV A D D ++ Y+I+ GN +
Sbjct: 911 VLDVNDNPPVFEQDEFDVF--VEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEV 968
Query: 840 ILLNETTGSMT 850
L+ +G +T
Sbjct: 969 FQLDIFSGELT 979
Score = 281 bits (688), Expect = 3e-74
Identities = 203/635 (31%), Positives = 311/635 (48%), Gaps = 29/635 (4%)
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
R+VN AP+F +Q +V EN P G + ++A D DEG L YTM D + +
Sbjct: 173 RNVN-TAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM-DALFDSRSNQ 230
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++DP +G V T+ +LDRET++ + VTA D G P RSA AT F
Sbjct: 231 FFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFE 290
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDAD---EDNRLH--YEITGGNTRGRFSITSQNGRGL 422
+Y+ L E+ G V+T+ ATD D N L+ E +GG+ F I ++ G+
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRS--GV 348
Query: 423 ITVAQPLDFKQERRYVLTVSATDS----GGRSDTAMVQINITDANNYAPVFENAPYTASV 478
I P+D ++ Y LTV A+D G RS TA V +++ D N+ AP F Y V
Sbjct: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED G VL V+A+D D G NA + YS+ S + QF ++ QTGA+
Sbjct: 409 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMS-------GNARGQFYLDAQTGALDVVSP 461
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LD ET Y L V A+DGG P LS+ + V + V+D+NDN P+F + A ++E +G
Sbjct: 462 LDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG 521
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
V V A DAD G N R+ Y L + F I+ +G I LDRE V +
Sbjct: 522 YLVLHVQAIDADAGDNARLEYRLAGVG-HDFPFTINNGTGWISVAAELDREEVDFYSFGV 580
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTP +++ V + + D+ND+ P F T ++E++ +GT++ + A D D
Sbjct: 581 EARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD-- 638
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
++V+ Y I G+ N FS+ ++ G L + LDY+ R +Y L + A+ +
Sbjct: 639 AHSVITYQITSGNTRNRFSITSQSGGGLVSLA--LPLDYKLER-QYVLAVTASDGTRQDT 695
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNN 836
++ + VTD N + PV + N +D P G + A D D + + ++
Sbjct: 696 AQIVVNVTDANTHRPVFQSSHYTVNVNED-RPAGTTVVLISATDEDTGENARITYFMEDS 754
Query: 837 ANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
++ TG++T +L+ T+ ++ D
Sbjct: 755 IPQFRIDADTGAVTTQAELDYEDQVSYTLAITARD 789
Score = 214 bits (523), Expect = 3e-54
Identities = 155/438 (35%), Positives = 223/438 (50%), Gaps = 26/438 (5%)
Query: 464 NYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQ 523
N AP F+ Y A+V E+ P GT V + A D D G ++ Y++ + + + +Q
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRS----NQF 231
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ 583
F ++P TGA+TT + LDRET S ++ VTA+D G+P S + I V D ND++PVF+Q
Sbjct: 232 FSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQ 291
Query: 584 QLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRT 641
Q Y ++ E+ VG V V ATD D N I Y L S F IDP SGVIRT
Sbjct: 292 QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351
Query: 642 NKALDRESVATHDLKAVAIDGGTP--PQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
+DRE V ++ L A D G P+S+T V + +ED ND+ P F + E+
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED 411
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
G + + A D D+G NAVVHYSI G+ F L+ + G+ L + LDYE+
Sbjct: 412 VTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGA----LDVVSPLDYET- 466
Query: 760 RKKYELVIRA---ASPPLWN-DVRVEILVTDVNDNAP--VMKDFQIIFNNYKDCFPVGPF 813
K+Y L +RA PPL N V + V D+NDNAP V FQ + P+G
Sbjct: 467 TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA---TVLESVPLGYL 523
Query: 814 G-RVPAYDADVTD--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVT 870
V A DAD D +L+YR+ + +N TG ++++ +L+ + V
Sbjct: 524 VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
Query: 871 D-GVNEIKAMMQLSVRLI 887
D G + A +SV ++
Sbjct: 584 DHGTPALTASASVSVTVL 601
Score = 125 bits (301), Expect = 3e-27
Identities = 104/337 (30%), Positives = 159/337 (47%), Gaps = 38/337 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P F Y+ SV E T+VL + ATD+D G N V YT +
Sbjct: 802 EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ------ 855
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D F ++ SG + T LDRE VA+Y + A D+ P +
Sbjct: 856 -GGDDGDGD-----------FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPA-- 901
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+ + V ++D NDN P F + + V V+E+ + +A++ ATD D G N+ I Y
Sbjct: 902 -RTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI--GLAVARVTATDPDEGTNAQIMY 958
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
I+ GN F +D SG+++ + LDYE Y LVI+A SR+ + + + D
Sbjct: 959 QIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRAT---VHVRLLD 1015
Query: 250 VNDNAPRF--YTSLFQESV---SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
NDN P + LF V S + P G +I RV A+D D ++ LTY+ GN
Sbjct: 1016 RNDNPPVLGNFEILFNNYVTNRSSSFP-GGAIGRVPAHDPD--ISDSLTYSFE----RGN 1068
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG 341
+ ++ +G + S LD + + V +DG
Sbjct: 1069 ELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
Score = 54.8 bits (126), Expect = 4e-06
Identities = 45/148 (30%), Positives = 79/148 (53%), Gaps = 18/148 (12%)
Query: 2176 LKKPIRLQIWLDINRETFGSRTNPQCVHWS---TLRGSGEWSRVGCHTEIDYDWSPYSEE 2232
L KP+ +Q L E RT P CV W+ + G+G WS GC E+ + +
Sbjct: 2298 LDKPVTVQFRLLETEE----RTKPICVFWNHSILVSGTGGWSARGC--EVVFRNESH--- 2348
Query: 2233 PLLINCTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCLIRG 2292
++C CNH+++FAVL+D V E L+++T Y A ++L LL ++ L L+R
Sbjct: 2349 ---VSCQCNHMTSFAVLMD-VSRRENGEILPLKTLT-YVALGVTLAALLLTFFFLTLLR- 2402
Query: 2293 GAATVSNSIHKHLIFSVFMAELLYLIAL 2320
+ + I ++L ++ +A+L++L+ +
Sbjct: 2403 ILRSNQHGIRRNLTAALGLAQLVFLLGI 2430
Score = 37.5 bits (83), Expect = 0.69
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 6/76 (7%)
Query: 1509 DGCQSRAD-CMLSICPPYSKCVTSWDSSTCTCEAGRVGPQC-VSA----CELGPCGAARC 1562
D C++ D C C P+ +C + TC C G G C VSA C G C
Sbjct: 1283 DYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGT 1342
Query: 1563 VPDQTPKGYSCACEPG 1578
+ G+ C C G
Sbjct: 1343 CVNLLVGGFKCDCPSG 1358
Score = 35.1 bits (77), Expect = 3.7
Identities = 32/96 (33%), Positives = 36/96 (37%), Gaps = 17/96 (17%)
Query: 1537 CTCEAGRVGPQC---VSACELGPCGA-ARCVPDQTPKGYSCACEPGYTLTTSGCIESGKE 1592
C C G G C V C PCG RC + GY+C C GY T C S +
Sbjct: 1274 CRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREG--GYTCLCRDGY--TGEHCEVSARS 1329
Query: 1593 -EC-PGGWWGGSAC-----GPCACDVTRG--YHPHC 1619
C PG G C G CD G P+C
Sbjct: 1330 GRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYC 1365
Score = 33.9 bits (74), Expect = 8.5
Identities = 13/39 (33%), Positives = 18/39 (46%)
Query: 1310 CPEKRSRCSSAPCYNGAECSDLWDTYICDCKEGHTGKDC 1348
C + C S PC C Y C C++G+TG+ C
Sbjct: 1285 CETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHC 1323
>BC000059-1|AAH00059.2| 771|Homo sapiens CELSR1 protein protein.
Length = 771
Score = 702 bits (1734), Expect = 0.0
Identities = 361/790 (45%), Positives = 503/790 (63%), Gaps = 33/790 (4%)
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
D P I SGW+ +LDRE Y V A D G PP S++ +
Sbjct: 1 DFPFQIHNSSGWITVCAELDREEVDHYSFGVEAVDHGWPPMSSSTSVSITVLDVNDNDPV 60
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITV 425
F YE+ L ED G+ V+TL A D D ++ + Y++TGGNTR RF+++SQ G GLIT+
Sbjct: 61 FTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITL 120
Query: 426 AQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
A PLD+KQE++YVL V+A+D G RS TA V IN+TDAN + PVF+++ YT SV ED P+G
Sbjct: 121 ALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVG 179
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
T++ +SA D D G NA+ITY + + QF I+P +G + T LD E
Sbjct: 180 TSIATLSANDEDTGENARITYVIQDPVP---------QFRIDPDSGTMYTMMELDYENQV 230
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
Y LT+ A+D G+P SDTT +EI ++D NDN P F Y +I EDA TS+ QV A
Sbjct: 231 AYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSA 290
Query: 606 TDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
TD D G NGR+ Y D +G F I+P SGVIRT + LDRE+VA ++L A+A+D G+P
Sbjct: 291 TDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSP 350
Query: 666 -PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHY 724
P S++V + + I DIND+ P+FE D L ++ EN+P+G+ + +IRA+DPDEGPNA + Y
Sbjct: 351 TPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMY 410
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILV 784
I GD + F L+ G +L MV+LD+E R++Y LV++A S PL + V IL+
Sbjct: 411 QIVEGDMRHFFQLDLLNG----DLRAMVELDFEV-RREYVLVVQATSAPLVSRATVHILL 465
Query: 785 TDVNDNAPVMKDFQIIFNNY----KDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLI 840
D NDN PV+ DFQI+FNNY + FP G GR+PA+D DV+D L Y + GN L+
Sbjct: 466 VDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGRIPAHDPDVSDSLNYTFVQGNELRLL 525
Query: 841 LLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRL 900
LL+ TG + LS L+ N P A MEVSV+DG++ + A L V +IT++ML NSITVRL
Sbjct: 526 LLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRL 585
Query: 901 NDMTAEQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSARRPDAEV 960
+M+ E+FLSPLL F++G+AA++ K+++++F+VQ+DTDV+ NILNV+FSA P
Sbjct: 586 ENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSALLPG--- 642
Query: 961 GVAGDPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEECLTVLKFG 1020
GV G + L+E++YL+RT L ++T +VLPFDDNIC+ EPC N+ +C++VL+F
Sbjct: 643 GVRGQ---FFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFD 699
Query: 1021 NASGFVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCV 1080
+++ F++S +VLFRPI+P+ C+CP GFTG CET + + G CRS
Sbjct: 700 SSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRS----- 754
Query: 1081 ARREGGILCQ 1090
REGG C+
Sbjct: 755 --REGGYTCE 762
Score = 256 bits (627), Expect = 8e-67
Identities = 197/604 (32%), Positives = 297/604 (49%), Gaps = 44/604 (7%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F+I SG + A LDRE+V Y+ V+A D P +SS+ ++ + ++D NDN P
Sbjct: 4 FQIHNSSGWITVCAELDREEVDHYSFGVEAVDHGWPP---MSSSTSVSITVLDVNDNDPV 60
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGD- 208
F++ TY + ++ED +V + + ++A D D ANS I Y + GGNT+ +F++ S G
Sbjct: 61 FTQPTYELRLNEDAAVGSS--VLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGG 116
Query: 209 -VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVS 267
++L LDY+Q + Y L + A DG +RS+T +LIN+ D N + P F +S + SVS
Sbjct: 117 LITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVS 173
Query: 268 ENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP-ITIDPRSGWVYTSGQLDR 326
E+ P+G SI + A D D G NA +TY + D +P IDP SG +YT +LD
Sbjct: 174 EDRPVGTSIATLSANDEDTGENARITYVIQD-------PVPQFRIDPDSGTMYTMMELDY 226
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
E Q Y L + A D G P +S T T F+ Y+ + ED PP T ++
Sbjct: 227 ENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSIL 286
Query: 387 TLTATDADE--DNRLHYEITGGNT-RGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
++ATD D + RL Y GG+ G F I + G+I + LD + Y L A
Sbjct: 287 QVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS--GVIRTQRRLDRENVAVYNLWALA 344
Query: 444 TDSGG---RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
D G S + +Q+ I D N+ AP+FE V E+ P+G+ V + A D D G
Sbjct: 345 VDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGP 404
Query: 501 NAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
NAQI Y +I + H Q ++N A+ LD E Y+L V A P
Sbjct: 405 NAQIMY----QIVEGDMRHFFQLDLLNGDLRAMVE---LDFEVRREYVLVVQAT--SAPL 455
Query: 561 LSDTTDVEISVVDVNDNEPVFKQ-QLYTANIMEDALVGTSVSQVGATDA-DVGLNGRIHY 618
+S T V I +VD NDN PV Q+ N + + +G A D ++ ++Y
Sbjct: 456 VSRAT-VHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGRIPAHDPDVSDSLNY 514
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
+ E ++DPA+G ++ ++ LD L V++ G S T +++
Sbjct: 515 TF-VQGNELRLLLLDPATGELQLSRDLDNNR-PLEALMEVSVSDGI--HSVTAFCTLRVT 570
Query: 679 DIND 682
I D
Sbjct: 571 IITD 574
Score = 251 bits (615), Expect = 2e-65
Identities = 186/570 (32%), Positives = 289/570 (50%), Gaps = 38/570 (6%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
F I + SG +++ LD E+V Y + A D G P S++T + I + DVNDN P F
Sbjct: 4 FQIHNSSGWITVCAELDREEVDHYSFGVEAVDHGWPPMSSSTSVSITVLDVNDNDPVFTQ 63
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
++ ++E+ +G S++ +QA D D N+ +TY +T + T N ++ G +
Sbjct: 64 PTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGN-TRN-RFALSSQRGGGLIT 119
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
+ LD + + +Y L VTA+DG RS TA F Y V ++ED
Sbjct: 120 LALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDR 176
Query: 380 PPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
P GT + TL+A D D E+ R+ Y I + +F I +G + T+ + LD++ + Y
Sbjct: 177 PVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRIDPDSGT-MYTMME-LDYENQVAY 232
Query: 438 VLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
LT+ A D+G +SDT ++I I DAN+ AP F Y S+FEDAP T++L VSATD
Sbjct: 233 TLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATD 292
Query: 496 SDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
D G N ++ Y+ D F I P +G I T + LDRE ++ Y L A D
Sbjct: 293 RDSGPNGRLLYTFQGGDDG------DGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVD 346
Query: 556 GGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
G P+ LS + +++++++D+NDN P+F++ + E+ VG+ V+++ A D D G N
Sbjct: 347 RGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNA 406
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
+I Y++ D F +D +G +R LD E + + + + P S VH
Sbjct: 407 QIMYQIVEGDMRH-FFQLDLLNGDLRAMVELDFEVRREY---VLVVQATSAPLVSRATVH 462
Query: 675 IKIEDINDSPPVFESDCLTF--YISENS---PIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
I + D ND+PPV + F Y++ S P G IG I AHDPD + ++Y+ G
Sbjct: 463 ILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGRIPAHDPDVSDS--LNYTFVQG 519
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESP 759
++ L+ G EL DLD P
Sbjct: 520 NELRLLLLDPATG----ELQLSRDLDNNRP 545
Score = 223 bits (545), Expect = 7e-57
Identities = 186/572 (32%), Positives = 269/572 (47%), Gaps = 58/572 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ PVF YE + E A+ G++VLTL+A D+D N+ + Y +L +T
Sbjct: 49 ITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITY--QLTGGNTR 104
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRA-SLDREKVARYTVLVKATDQASPVSD 128
N F + R G L+T A LD ++ +Y + V A+D
Sbjct: 105 NR-----------------FALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR---- 143
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA + +N+ D N + P F YTVSV ED V + IA + A D D G N+ I
Sbjct: 144 --SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTS--IATLSANDEDTGENARIT 199
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y I + QF ID SG + + LDYE +Y L I AQD G P +S+TT L I I
Sbjct: 200 YVI--QDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILIL 257
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D NDNAP+F +Q S+ E+ P SI++V A D D G N L YT D G+ D
Sbjct: 258 DANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGD-DGDGD-- 314
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP-PRSATATXXXXXXXXXXXXXXFM 367
I+P SG + T +LDRE A Y L A D G P P SA+ F
Sbjct: 315 FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE 374
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITV 425
+ E+ + E+ P G+ V + A D DE + ++ Y+I G+ R F + NG +
Sbjct: 375 KDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGD--LRA 432
Query: 426 AQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAP-----YTASVFE 480
LDF+ R YVL V AT S A V I + D N+ PV + Y +
Sbjct: 433 MVELDFEVRREYVLVVQAT-SAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSN 491
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
P G + + A D DV + T+ +E+ + +++P TG + ++ LD
Sbjct: 492 SFPTG-VIGRIPAHDPDVSDSLNYTFVQGNEL---------RLLLLDPATGELQLSRDLD 541
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVV 572
L+ V+ D G+ S++ + ++++
Sbjct: 542 NNRPLEALMEVSVSD-GIHSVTAFCTLRVTII 572
Score = 177 bits (430), Expect = 6e-43
Identities = 139/457 (30%), Positives = 208/457 (45%), Gaps = 38/457 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H INV D N H PVF+ Y SV E GT++ TL A D+D G+NA + Y I+
Sbjct: 148 HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ---- 203
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
D + P+ FRID SG + T LD E YT+ + A D P
Sbjct: 204 DPV-PQ----------------FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP-- 244
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
+ S T T+ + I+D NDN PQF Y S+ ED + + I ++ ATD D G N +
Sbjct: 245 -QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTS--ILQVSATDRDSGPNGRL 301
Query: 188 RYAIIGGNT-QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS-RSNTTQLLI 245
Y GG+ F I+ SG + + LD E V Y L A D GSP+ S + ++ +
Sbjct: 302 LYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQV 361
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D+NDNAP F + V EN P+G + +++A D DEG NA++ Y + + G++
Sbjct: 362 TILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVE----GDM 417
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+D +G + +LD E + +Y L+V AT R+
Sbjct: 418 RHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPD 477
Query: 366 F--MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLI 423
F + Y + P G + + A D D + L+Y GN + G +
Sbjct: 478 FQILFNNYVTNKSNSFPTGV-IGRIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGE--L 534
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT 460
+++ LD + ++ VS +D G S TA + +T
Sbjct: 535 QLSRDLDNNRPLEALMEVSVSD-GIHSVTAFCTLRVT 570
>X87241-1|CAA60685.1| 4590|Homo sapiens homologue of Drosophila Fat
protein protein.
Length = 4590
Score = 459 bits (1132), Expect = e-128
Identities = 407/1378 (29%), Positives = 639/1378 (46%), Gaps = 137/1378 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND+SPVFE YEA + E G+ V+ ++A+D D G N +V Y+++
Sbjct: 2799 IQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLD------- 2851
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V + F I+ +G + T LD EK Y + V A+D + +L
Sbjct: 2852 ---------QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKI--QL 2900
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGA-NSAIRY 189
SSTA + V + D ND+ P+F+ + Y +V ED VIA + TDAD N + Y
Sbjct: 2901 SSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDP--QGGVIAILSTTDADSEEINRQVTY 2958
Query: 190 AIIGGNTQMQFSIDSLSGD--VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I GG+ QF+++++ + V + K LD E+ +Y L I A DG S++ + +
Sbjct: 2959 FITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVE---VKV 3015
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D NDN+P +L+ +++ E+V G I+++ A DAD NAE+TYT+ G+
Sbjct: 3016 LDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLL-----GSGAE 3070
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++P +G + TS LDRE QA Y LLV ATDGG R A+ F
Sbjct: 3071 KFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVVTLEDVNDNAPEFS 3128
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITV 425
Y + + E+ PGT + + ATDAD + ++ Y + + G+FSI +G +I +
Sbjct: 3129 ADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLID-SADGQFSINELSG--IIQL 3185
Query: 426 AQPLDFKQERRYVLTVSATDSG---GRSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+PLD + + Y L++ A D G + T V +++ D N+ PVFE Y A+V ED
Sbjct: 3186 EKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDI 3245
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
+GT VL V A D+ NA+ITYS+ S NE H + F I+ +TGA+ + LD E
Sbjct: 3246 LVGTEVLQVYAASRDIEANAEITYSIIS--GNE----HGK-FSIDSKTGAVFIIENLDYE 3298
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
+ Y LTV A DGG PSLSD V ++V D+NDN PVF Q YT I EDA++ SV
Sbjct: 3299 SSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVIT 3358
Query: 603 VGATDADVGLNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAID 661
V A DAD N IHY + D +G SF IDP G ++ K LDRE+++ + L A D
Sbjct: 3359 VMADDADGPSNSHIHYSI--IDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3416
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA- 720
G+PP+ +T V+I + D+ND+ PVF + I EN P+G ++ ++ D D N
Sbjct: 3417 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3476
Query: 721 VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRV 780
++I G+D +F + + + + + D+ + K V P L + +
Sbjct: 3477 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVK---VADNGKPQLSSLTYI 3533
Query: 781 EILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLI 840
+I V + + P + +I + + + G G++ A D DV D L Y L NL
Sbjct: 3534 DIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQDVYDTLTYS-LDPQMDNLF 3592
Query: 841 LLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRL 900
++ T G + +L+ + VSVTDG A + + +R +T+EML ++I +R
Sbjct: 3593 SVSSTGGKLIAHKKLDIG---QYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRF 3649
Query: 901 NDMTAEQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSARRPDAEV 960
++T E+F+ F L I+ + +I I S+Q L+V +P
Sbjct: 3650 ANLTPEEFVGDYWRNFQRALRNILGVRRNDIQIVSLQSSEPHPH--LDVLLFVEKPG--- 3704
Query: 961 GVAGDPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEECLTVLKFG 1020
S S L ++ T + + V++L +C C ++ C +
Sbjct: 3705 ------SAQISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAGLDC-PWKFCDEKVSVD 3757
Query: 1021 NASGFVNSDSVL-FRPIYPVTSFTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQC 1079
+ +S + L F + C C EG C + CE D C GS+C
Sbjct: 3758 ESVMSTHSTARLSFVTPRHHRAAVCLCKEG----RCPPV--HHGCEDDP----CPEGSEC 3807
Query: 1080 VA---RREGGILCQGCSIDAAYTTAVCELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQ 1136
V+ + +C ++ L S+ V LT K ++ ++L+ T
Sbjct: 3808 VSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSY-VKYRLTENENKLEMKLTMRLR--TY 3864
Query: 1137 TTSGLLLYNGRYNERHDFLALELVSSEAGRGGGPGLRFSFSLGGGKSEITVEG-NVGDGS 1195
+T +++ Y D+ LE+ GR L++ F G G ++V+ V DG
Sbjct: 3865 STHAVVM----YARGTDYSILEI---HHGR-----LQYKFDCGSGPGIVSVQSIQVNDGQ 3912
Query: 1196 WHTVEIEYFNRTITMILDDCDKVLSLAGAADFGLKYACANFTRKVLPARCEIPTETCHRF 1255
WH V +E ++L D+V + +G A LK T +
Sbjct: 3913 WHAVALEVNGNYARLVL---DQVHTASGTAPGTLK------------------TLNLDNY 3951
Query: 1256 LDLTGPLQIGGLPNIPSSFQVKNKDFVGCISDFYIDHKFIDLNS------YVADNGTLA- 1308
+ G ++ G + S QV N F GC+ Y++ + + LNS ++ ++ ++
Sbjct: 3952 VFFGGHIRQQGTRH-GRSPQVGN-GFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSP 4009
Query: 1309 GC-PEKRSRCSSAPCYNGAECS-DLWDTYICDCKEGHTGKDCADSTGP----PWRFGG 1360
GC C+S PC NG C+ Y C C + G C S P P +GG
Sbjct: 4010 GCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSNPCLYGG 4067
Score = 403 bits (992), Expect = e-111
Identities = 281/880 (31%), Positives = 449/880 (51%), Gaps = 54/880 (6%)
Query: 3 VPFCIHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
V FC I + D ND++P F +YE ++ A+ GT+V+ A+D D G NA++ Y I
Sbjct: 2580 VAFCTVNVI-LTDDNDNAPQFRATKYEVNIGSSAAKGTSVVK-SASDADEGSNADITYAI 2637
Query: 63 ELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQ 122
E AD+ V++ I+ SG + T+ SL + +T V+A D
Sbjct: 2638 E---ADS--------------ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDN 2680
Query: 123 ASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVG 182
SP + S ++V I+ P+FSE YT +V ED+ V I I+A +
Sbjct: 2681 GSPSKE---SVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPV--GTEIDLIRAEHSGTV 2735
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTT 241
S ++ N F ID SG + L K+LD+E + Y+ I A+ +
Sbjct: 2736 LYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASV 2795
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ I ++D NDN+P F +S ++ + EN+P G +++++A DAD G N ++ Y++ D+
Sbjct: 2796 DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL-DQSQ 2854
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR-SATATXXXXXXXXX 360
+ V I+ +GW+ T +LD E + YQ+ V A+D G+ + S+TA
Sbjct: 2855 SVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVN 2914
Query: 361 XXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNR-LHYEITGGNTRGRFSITSQ 417
F Y+ ++ED+P G + L+ TDAD E NR + Y ITGG+ G+F++ +
Sbjct: 2915 DSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETI 2974
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTAS 477
+ V +PLD ++ Y+LT++ATD G S A+V++ + DAN+ +PV E Y+ +
Sbjct: 2975 QNEWKVYVKKPLDREKRDNYLLTITATD-GTFSSKAIVEVKVLDANDNSPVCEKTLYSDT 3033
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ ED G ++ +SATD+D+ NA+ITY+L + ++F +NP TG + T+
Sbjct: 3034 IPEDVLPGKLIMQISATDADIRSNAEITYTL--------LGSGAEKFKLNPDTGELKTST 3085
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LDRE + Y L V A DGG + +++ DVNDN P F Y + E+ G
Sbjct: 3086 PLDREEQAVYHLLVRATDGG--GRFCQASIVVTLEDVNDNAPEFSADPYAITVFENTEPG 3143
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T +++V ATDAD GLN +I Y L D +G F I+ SG+I+ K LDRE A + L
Sbjct: 3144 TLLTRVQATDADAGLNRKILYSL--IDSADGQFSINELSGIIQLEKPLDRELQAVYTLSL 3201
Query: 658 VAIDGGTPPQ-SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
A+D G P + ++T V + + DIND+PPVFE +SE+ +GT + ++ A D
Sbjct: 3202 KAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDI 3261
Query: 717 GPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
NA + YSI G++ FS++++ G+ + + +LDYES +Y L + A +P
Sbjct: 3262 EANAEITYSIISGNEHGKFSIDSKTGA----VFIIENLDYESSH-EYYLTVEATDGGTPS 3316
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRI 831
L + V + VTD+NDN PV +D V A DAD + Y I
Sbjct: 3317 LSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSI 3376
Query: 832 LSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ GN + ++ G + ++ L+ T+ V +D
Sbjct: 3377 IDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3416
Score = 320 bits (787), Expect = 3e-86
Identities = 251/810 (30%), Positives = 390/810 (48%), Gaps = 69/810 (8%)
Query: 1 MSVPFCIHQQINVLDCND--HSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEV 58
+S+ + ++ V+D N+ H PVF + +V+E A G+ V+T+ A D+D G++ E+
Sbjct: 1010 VSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAGRDGEI 1069
Query: 59 EYTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVK 118
Y+I D VF+I +G + T LDRE + Y + V
Sbjct: 1070 RYSIR----------DGSGVG---------VFKIGEETGVIETSDRLDRESTSHYWLTVF 1110
Query: 119 ATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATD 178
ATDQ LSS I++ + D NDN PQ SE Y + E+ S D V+ +I+A D
Sbjct: 1111 ATDQGVVP---LSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMEN-SPKDVSVV-QIEAFD 1165
Query: 179 ADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLV-KTLDYEQVRSYRLVIRAQDGGSPSR 237
D +N + Y I GN Q FSI +G ++ + LD EQ + L + D GSP +
Sbjct: 1166 PDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPK 1225
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYS-------IVRVQAYDADEGVNA 290
S ++++ I D NDN P+F ++ + E + RV A D DEG NA
Sbjct: 1226 STIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYRVIATDKDEGPNA 1285
Query: 291 ELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLL-VTATDGGDPPRSAT 349
E++Y++ D GN I+P++G V +S + +Y +L + A D G P +S+T
Sbjct: 1286 EISYSIED----GNEHGKFFIEPKTG-VVSSKRFS--AAGEYDILSIKAVDNGRPQKSST 1338
Query: 350 ATXXXXXXXXXXXXX---XFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG 406
F + + E +P + ++ L ++ITGG
Sbjct: 1339 TRLHIEWISKPKQSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIP--LWFDITGG 1396
Query: 407 NTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYA 466
N F + G G I VA+PLD +Q+ Y LTV ATD G + V I + D N++
Sbjct: 1397 NYDSHFDV--DKGTGTIIVAKPLDAEQKSNYNLTVEATD-GTTTILTQVFIKVIDTNDHR 1453
Query: 467 PVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
P F + Y + ED T +L +SA D D ++ Y+L S S + ++ ++F +
Sbjct: 1454 PQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQS--SRDPLSL--KKFRL 1507
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLY 586
+P TG++ T++ LD E +S LTV RD VP + + ++V D ND+ P F Y
Sbjct: 1508 DPATGSLYTSEKLDHEAVSPAHLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSY 1567
Query: 587 TANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD--REEGSFVIDPASGVIRTNKA 644
+ E A VG+ V QV A D D G N + Y ++ + SF+IDP G I+T K
Sbjct: 1568 KGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNIGNSFMIDPVLGSIKTAKE 1627
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
LDR + A +DL A D G+PP S V I + +++ P F S + +SE IG+
Sbjct: 1628 LDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGS 1687
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
+G + AH + V Y IK G+ ++F + G+ ++T LD+E+ Y
Sbjct: 1688 FVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT----IITQKALDFET-LPIYT 1737
Query: 765 LVIRAAS-PPLWNDVRVEILVTDVNDNAPV 793
L+I+ + L + V + + D NDNAPV
Sbjct: 1738 LIIQGTNMAGLSTNTTVLVHLQDENDNAPV 1767
Score = 319 bits (784), Expect = 8e-86
Identities = 249/814 (30%), Positives = 394/814 (48%), Gaps = 56/814 (6%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D F I+ SG ++T+ +LD E + YT++++ T+ A LS+ T+ V++ D+NDN
Sbjct: 1711 DAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAG-----LSTNTTVLVHLQDENDNA 1765
Query: 148 PQFSEKTYTVSVDEDISV-----TDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI 202
P F + YT + E S+ TD V I+A DAD +N+ + Y I+ + F+I
Sbjct: 1766 PVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAI 1825
Query: 203 DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQLLINIRDVNDNAPRFYTS 260
DS +G + V +LDYE+ + ++ D G+P + +++ D+ND P F
Sbjct: 1826 DSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKP 1885
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
L++ S+ G ++ V A DAD ++L Y++T+ GN+ ++D ++G +
Sbjct: 1886 LYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE----GNIGEKFSMDYKTGALTV 1941
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX-FMPGQYEVELAEDE 379
Q + +++Y+L V A+DG R A T F Y + E+
Sbjct: 1942 --QNTTQLRSRYELTVRASDG----RFAGLTSVKINVKESKESHLKFTQDVYSAVVKENS 1995
Query: 380 PPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
+ +TA + + L Y I N RF I+ +G L T P D +Q+ + +
Sbjct: 1996 TEAETLAVITAIGSPINEPLFYHIL--NPDRRFKISRTSGV-LSTTGTPFDREQQEAFDV 2052
Query: 440 TVSATDSGGRSDTA--MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
V + S A +V++ + D N+ APVF N PY A V D +G + V+A D D
Sbjct: 2053 VVEVIEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2112
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG-YLLTVTARDG 556
G N ++ Y L H + F I P G I+ K + +T++ YL+TV A+DG
Sbjct: 2113 SGRNGEVHYYLKE---------HHEHFQIGP-LGEISLKKQFELDTLNKEYLVTVVAKDG 2162
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
G P+ S V I+V+ N PVF++ Y+A I E V + V V A + GL ++
Sbjct: 2163 GNPAFSAEVIVPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE-GL--KV 2217
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
Y + D F I+ +GVI LD E+ + L A D T + V V I
Sbjct: 2218 FYSITDGD-PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAE-VFVDII 2275
Query: 677 IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
++DIND+PPVF +SE S IGT++ ++RA D D PN + Y + G +
Sbjct: 2276 VDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDH 2335
Query: 737 LETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPV 793
+ L+ LDYE R ++ + +RA P L +DV V + VTD+N N P+
Sbjct: 2336 FHVDSSTGLISLLR--TLDYEQSR-QHTIFVRAVDGGMPTLSSDVIVTVDVTDLNGNPPL 2392
Query: 794 MKDFQIIFNNYKDCFPVGPFGR-VPAYDADVT--DKLQYRILSGNNANLILLNETTGSMT 850
+ QI + P G F V AYDAD + DKLQY ILSGN+ +++ TG +T
Sbjct: 2393 FEQ-QIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIIT 2451
Query: 851 LSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSV 884
LS + ++ +SV+DGV + ++V
Sbjct: 2452 LSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTV 2485
Score = 312 bits (766), Expect = 1e-83
Identities = 259/893 (29%), Positives = 413/893 (46%), Gaps = 93/893 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++++ D ND+ P F Y VRE GT ++ L+A D D+G++ +V Y++
Sbjct: 914 KVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSL------- 966
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
L+ + F +D SGA+ LD EK Y + V+A D+ PVS
Sbjct: 967 LDHGEGN-------------FDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS-- 1011
Query: 130 LSSTATIHVNIIDDNDNY--PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LSST + V ++D N+N P FS +V ED V ++ + A D D G + I
Sbjct: 1012 LSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPV--GSLVMTVSAHDEDAGRDGEI 1069
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
RY+I G+ F I +G + LD E Y L + A D G S+ ++ I +
Sbjct: 1070 RYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEV 1129
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
DVNDNAP+ ++ + EN P S+V+++A+D D N +L Y +T +GN
Sbjct: 1130 EDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKIT----SGNPQG 1185
Query: 308 PITIDPRSGWV-YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+I P++G + TS +LDRE Q ++ L VT TD G PP+S A F
Sbjct: 1186 FFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF 1245
Query: 367 MPGQYEVELAEDEPPG-------TPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQ 417
+ Y++ L E E P P+ + ATD DE + + Y I GN G+F I +
Sbjct: 1246 LQKFYKIRLPEREKPDRERNARREPLYRVIATDKDEGPNAEISYSIEDGNEHGKFFIEPK 1305
Query: 418 NGRGLITVAQPLDFKQERRY-VLTVSATDSGGRSDTAMVQINI----TDANNYAPV-FEN 471
G V F Y +L++ A D+G ++ +++I + P+ FE
Sbjct: 1306 TG-----VVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKQSLEPISFEE 1360
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
+ +T +V E P+ + V+S + + IT ++D F ++ TG
Sbjct: 1361 SFFTFTVMESDPVAHMIGVISVEPPGIPLWFDIT-----------GGNYDSHFDVDKGTG 1409
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
I K LD E S Y LTV A DG L T V I V+D ND+ P F Y I
Sbjct: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTTTIL---TQVFIKVIDTNDHRPQFSTSKYEVVIP 1466
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYEL----DPKDREEGSFVIDPASGVIRTNKALDR 647
ED T + Q+ A D D ++ Y L DP ++ F +DPA+G + T++ LD
Sbjct: 1467 EDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKK--FRLDPATGSLYTSEKLDH 1522
Query: 648 ESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIG 707
E+V+ L + D P + + + + + D ND P F + + E++ +G+ +
Sbjct: 1523 EAVSPAHLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVL 1582
Query: 708 EIRAHDPDEGPNAVVHYSIKG---GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
++ A D D+G NA V YSI+ G+ NSF ++ GS K T +LD S + +Y+
Sbjct: 1583 QVTALDKDKGKNAEVLYSIESGNIGNIGNSFMIDPVLGSIK----TAKELD-RSNQAEYD 1637
Query: 765 LVIRA---ASPPLWNDVRVEILVTDVNDNAP--VMKDFQIIFNNYKDCFPVGPF-GRVPA 818
L+++A SPP+ V I VT ++ +P K++ + + +G F G V A
Sbjct: 1638 LMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSV---ELSETVSIGSFVGMVTA 1694
Query: 819 YDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ + Y I GN + +N +G++ L+ + T+ + T+
Sbjct: 1695 HS---QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTN 1744
Score = 300 bits (736), Expect = 5e-80
Identities = 226/718 (31%), Positives = 356/718 (49%), Gaps = 44/718 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDD--NDNY 147
F I+ +G + A LD E Y + ++ATD + + A + V+II D NDN
Sbjct: 2230 FTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLT------GAHAEVFVDIIVDDINDNP 2283
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQ--FSIDSL 205
P F++++Y V++ E SV V+ +++ATD+D N I Y + G +++ F +DS
Sbjct: 2284 PVFAQQSYAVTLSE-ASVIGTSVV-QVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2341
Query: 206 SGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
+G +SL++TLDYEQ R + + +RA DGG P+ S+ + +++ D+N N P F +++
Sbjct: 2342 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNGNPPLFEQQIYEAR 2401
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SE+ P G+ + V+AYDAD +L Y++ +GN ID +G + S
Sbjct: 2402 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSI----LSGNDHKHFVIDSATGIITLSNLHR 2457
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
+ Y L ++ +DG RS+T F+ +YEVELAE+ P T V
Sbjct: 2458 HALKPFYSLNLSVSDG--VFRSSTQV-HVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2514
Query: 386 VTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV-- 441
+ + TD D + Y I + RF I N RG I + LD + V++V
Sbjct: 2515 MEVKTTDGDSGIYGHVTYHIVNDFAKDRFYI---NERGQIFTLEKLDRETPAEKVISVRL 2571
Query: 442 SATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
A D+GG+ V + +TD N+ AP F Y ++ A GT+V V SA+D+D G N
Sbjct: 2572 MAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSV-VKSASDADEGSN 2630
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
A ITY++ E +E+V + IN +G ITT + L + V A D G PS
Sbjct: 2631 ADITYAI--EADSESV---KENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSK 2685
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V + ++ P F + YT + ED VGT + + A + L +
Sbjct: 2686 ESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPVGTEIDLIRAEHSGTVLYSLVKGNTP 2745
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDI 680
+R+E SFVID SG ++ K+LD E+ + +A ++V V I+++D
Sbjct: 2746 ESNRDE-SFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDA 2804
Query: 681 NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSL--E 738
ND+ PVFES +I EN P G+ + +IRA D D G N V YS+ D S S +
Sbjct: 2805 NDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSL---DQSQSVEVIES 2861
Query: 739 TRQGSDKAELVTMVDLDYESPRKKYELVIRAASP----PLWNDVRVEILVTDVNDNAP 792
+ + T+ +LD+E R Y++ + A+ L + V++ VTDVND+ P
Sbjct: 2862 FAINMETGWITTLKELDHEK-RDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPP 2918
Score = 299 bits (735), Expect = 7e-80
Identities = 254/880 (28%), Positives = 400/880 (45%), Gaps = 78/880 (8%)
Query: 17 NDHSPVFEMQQYEA-SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDA 75
N H P F V+E G++V+ + +TD D G N ++ Y + D+
Sbjct: 710 NAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSC----- 764
Query: 76 XXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTAT 135
F ID +G L + LDRE +YT+ + D P + ++
Sbjct: 765 --------------FMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIP---QKAAWRL 807
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
+HV ++D NDN P+F +++Y V V ED V + I +++ATD D+G N + Y+I+
Sbjct: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEV--HSEIIQVEATDKDLGPNGHVTYSILTDT 865
Query: 196 TQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGG--SPSRSNTTQLLINIRDVNDN 253
FSIDS++G V++ + LD E + L I A+D P +T + +++ DVNDN
Sbjct: 866 D--TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDN 923
Query: 254 APRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
P F ++ V E++P G I+ ++A+D D G + ++ Y++ D GN D +D
Sbjct: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHG-EGNFD----VDK 978
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX---XFMPGQ 370
SG V QLD E + Y L V A D G P ++ F
Sbjct: 979 LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFV 1038
Query: 371 YEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
+ + ED P G+ V+T++A D D D + Y I G+ G F I + G+I +
Sbjct: 1039 EKGTVKEDAPVGSLVMTVSAHDEDAGRDGEIRYSIRDGSGVGVFKIGEET--GVIETSDR 1096
Query: 429 LDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGT 486
LD + Y LTV ATD G S + I + D N+ AP Y + E++P
Sbjct: 1097 LDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDV 1156
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAI-TTNKLLDRETMS 545
+V+ + A D D N ++ Y ++S + F I+P+TG I TT++ LDRE
Sbjct: 1157 SVVQIEAFDPDSSSNDKLMYKITS-------GNPQGFFSIHPKTGLITTTSRKLDREQQD 1209
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS------ 599
++L VT D G P S V + ++D NDN+P F Q+ Y + E
Sbjct: 1210 EHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARRE 1269
Query: 600 -VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAV 658
+ +V ATD D G N I Y ++ E G F I+P +GV+ + + + +D+ ++
Sbjct: 1270 PLYRVIATDKDEGPNAEISYSIE-DGNEHGKFFIEPKTGVVSSKRF---SAAGEYDILSI 1325
Query: 659 -AIDGGTPPQSSTVIVHIK-IEDINDS--PPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
A+D G P +SST +HI+ I S P FE TF + E+ P+ IG I
Sbjct: 1326 KAVDNGRPQKSSTTRLHIEWISKPKQSLEPISFEESFFTFTVMESDPVAHMIGVISV--- 1382
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPL 774
E P + + I GG+ + F ++ G+ ++ LD E + Y L + A
Sbjct: 1383 -EPPGIPLWFDITGGNYDSHFDVDKGTGT----IIVAKPLDAEQ-KSNYNLTVEATDGTT 1436
Query: 775 WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSG 834
+V I V D ND+ P + +D P ++ A D D +KL Y + S
Sbjct: 1437 TILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSS 1496
Query: 835 N---NANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ L+ TGS+ S +L+ A + V V D
Sbjct: 1497 RDPLSLKKFRLDPATGSLYTSEKLDHEAVSPAHLTVMVRD 1536
Score = 289 bits (709), Expect = 1e-76
Identities = 211/673 (31%), Positives = 332/673 (49%), Gaps = 56/673 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD ND+SPV E Y ++ E G ++ + ATD DI NAE+ YT+
Sbjct: 3012 EVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL------- 3064
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ F+++ +G L T LDRE+ A Y +LV+ATD
Sbjct: 3065 -------------LGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQ- 3110
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
A+I V + D NDN P+FS Y ++V E + ++ +++ATDAD G N I Y
Sbjct: 3111 ----ASIVVTLEDVNDNAPEFSADPYAITVFE--NTEPGTLLTRVQATDADAGLNRKILY 3164
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT-QLLINIR 248
++I + QFSI+ LSG + L K LD E Y L ++A D G P R T +++++
Sbjct: 3165 SLI-DSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVL 3223
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D+NDN P F + +VSE++ +G +++V A D NAE+TY++ +GN
Sbjct: 3224 DINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSI----ISGNEHGK 3279
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
+ID ++G V+ LD E+ +Y L V ATDGG P S AT F
Sbjct: 3280 FSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQ 3339
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVA 426
Y ++ED V+T+ A DAD ++ +HY I GN F+I RG + V
Sbjct: 3340 DTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPV--RGEVKVT 3397
Query: 427 QPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPI 484
+ LD + Y LTV A+D+G R +T V I+++D N+ APVF Y+ + E+ P+
Sbjct: 3398 KLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPV 3457
Query: 485 GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETM 544
G +VL + TD D N + + N+ ++ F +NPQ G + T+ + R+
Sbjct: 3458 GFSVLQLVVTDEDSSHNGP-PFFFTIVTGND-----EKAFEVNPQ-GVLLTSSAIKRKEK 3510
Query: 545 SGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALVGTSVSQV 603
YLL V D G P LS T ++I V++ + P + +++ + E+ G + ++
Sbjct: 3511 DHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEE-YSGGVIGKI 3569
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
ATD DV + Y LDP + + F + G + +K LD + + L V++ G
Sbjct: 3570 HATDQDV--YDTLTYSLDP--QMDNLFSVSSTGGKLIAHKKLD---IGQY-LLNVSVTDG 3621
Query: 664 TPPQSSTVIVHIK 676
+ + VHI+
Sbjct: 3622 KFTTVADITVHIR 3634
Score = 289 bits (708), Expect = 1e-76
Identities = 258/883 (29%), Positives = 412/883 (46%), Gaps = 74/883 (8%)
Query: 13 VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNP 72
V+D ND+ P F + Y V E + ++ ++ATD+D+G N V Y+I DT
Sbjct: 812 VVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSI---LTDT--- 865
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSS 132
D F ID +G + LDRE +++ ++A DQA +L S
Sbjct: 866 ---------------DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFS 909
Query: 133 TATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII 192
T + V++ D NDN P F Y V V ED+ + VI ++A D D+G + +RY+++
Sbjct: 910 TVVVKVSLEDVNDNPPTFIPPNYRVKVREDL--PEGTVIMWLEAHDPDLGQSGQVRYSLL 967
Query: 193 GGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSP-SRSNTTQLLINIRDVN 251
+ + F +D LSG V +V+ LD+E+ + Y L +RA+D G P S S+T + + + DVN
Sbjct: 968 -DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVN 1026
Query: 252 DNA-PRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
+N P ++S ++ +V E+ P+G ++ V A+D D G + E+ Y++ D G
Sbjct: 1027 ENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAGRDGEIRYSIRDGSGVG----VF 1082
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
I +G + TS +LDRE+ + Y L V ATD G P S+
Sbjct: 1083 KIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEP 1142
Query: 370 QYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQ 427
Y E+ E+ P VV + A D D +++L Y+IT GN +G FSI + G + T ++
Sbjct: 1143 VYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGL-ITTTSR 1201
Query: 428 PLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE-DAP- 483
LD +Q+ ++L V+ TD+G +S A V + I D N+ P F Y + E + P
Sbjct: 1202 KLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPD 1261
Query: 484 -----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
+ V ATD D G NA+I+YS+ E NE H +F I P+TG +++ +
Sbjct: 1262 RERNARREPLYRVIATDKDEGPNAEISYSI--EDGNE----HG-KFFIEPKTGVVSSKRF 1314
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD--VNDNEPV-FKQQLYTANIMEDAL 595
+L++ A D G P S TT + I + EP+ F++ +T +ME
Sbjct: 1315 SAAGEYD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKQSLEPISFEESFFTFTVMESDP 1372
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDL 655
V + + + L +++ + F +D +G I K LD E + ++L
Sbjct: 1373 VAHMIGVISVEPPGIPL----WFDI-TGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNL 1427
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
A DG T + V IK+ D ND P F + I E++ T I +I A D D
Sbjct: 1428 TVEATDGTT---TILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD 1484
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYE--SPRKKYELVIRAASPP 773
E N ++ Y+++ D S + R L T LD+E SP +V P
Sbjct: 1485 E-KNKLI-YTLQSSRDPLSLK-KFRLDPATGSLYTSEKLDHEAVSPAHLTVMVRDQDVPV 1541
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRI 831
N R+ + V+D ND+AP Y+ +V A D D ++ Y I
Sbjct: 1542 KRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI 1601
Query: 832 LSGNNANL---ILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
SGN N+ +++ GS+ + +L+ + + V TD
Sbjct: 1602 ESGNIGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATD 1644
Score = 272 bits (666), Expect = 2e-71
Identities = 213/716 (29%), Positives = 326/716 (45%), Gaps = 46/716 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F +D +G ++ LD E+ + Y + V+ATD + + + + + +ID ND+ PQ
Sbjct: 1402 FDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQ------VFIKVIDTNDHRPQ 1455
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQM---QFSIDSLS 206
FS Y V + ED + I +I A D D + + Y + + +F +D +
Sbjct: 1456 FSTSKYEVVIPEDTAPETE--ILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPAT 1511
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
G + + LD+E V L + +D P + N ++++N+ D ND+AP F S ++ V
Sbjct: 1512 GSLYTSEKLDHEAVSPAHLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRV 1571
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDR 326
E+ +G +++V A D D+G NAE+ Y++ + GN+ IDP G + T+ +LDR
Sbjct: 1572 YESAAVGSVVLQVTALDKDKGKNAEVLYSI-ESGNIGNIGNSFMIDPVLGSIKTAKELDR 1630
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
QA+Y L+V ATD G PP S + F +Y VEL+E G+ V
Sbjct: 1631 SNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVG 1690
Query: 387 TLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+T A + + YEI GNT F I + G I + LDF+ Y L + T+
Sbjct: 1691 MVT---AHSQSSVVYEIKDGNTGDAFDINPHS--GTIITQKALDFETLPIYTLIIQGTNM 1745
Query: 447 GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTV-------LVVSATDSDVG 499
G S V +++ D N+ APVF A YT + E A I + V LV+ A D+D
Sbjct: 1746 AGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKD 1805
Query: 500 INAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
NA + Y + E H F I+ TGAI T LD E S + TV D G P
Sbjct: 1806 SNALLVYHIV-----EPSVH--TYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTP 1858
Query: 560 SL--SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIH 617
L +V + V+D+ND PVF + LY A+++ G V V ATDAD ++
Sbjct: 1859 RLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLI 1918
Query: 618 YELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKI 677
Y + + E F +D +G + S ++L A DG +S V I +
Sbjct: 1919 YSITEGNIGE-KFSMDYKTGALTVQNTTQLRS--RYELTVRASDGRFAGLTS---VKINV 1972
Query: 678 EDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSL 737
++ +S F D + + ENS T+ I A N + Y I D F +
Sbjct: 1973 KESKESHLKFTQDVYSAVVKENSTEAETLAVITA--IGSPINEPLFYHILNPD--RRFKI 2028
Query: 738 ETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPV 793
+R + T D + + VI P V V+++V D NDNAPV
Sbjct: 2029 -SRTSGVLSTTGTPFDREQQEAFDVVVEVIEEHKPSAVAHVVVKVIVEDQNDNAPV 2083
Score = 254 bits (621), Expect = 4e-66
Identities = 229/798 (28%), Positives = 371/798 (46%), Gaps = 68/798 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND++PVF Y A V+ G + + A D+D G+N EV Y ++
Sbjct: 2071 KVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLK------ 2124
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ ++ F +D +L++E Y V V A D +P
Sbjct: 2125 -EHHEHFQIGPLGEISLKKQFELD----------TLNKE----YLVTVVAKDGGNPA--- 2166
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S+ + + ++ N P F + Y+ + E I V +PV+ ++A + + Y
Sbjct: 2167 FSAEVIVPITVM--NKAMPVFEKPFYSAEIAESIQV-HSPVV-HVQANSPE---GLKVFY 2219
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
+I G+ QF+I+ +G ++++ LD+E +Y+L IRA D + + + +I + D
Sbjct: 2220 SITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDII-VDD 2278
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
+NDN P F + ++SE IG S+V+V+A D+D N ++Y M +++ + D
Sbjct: 2279 INDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFG-NHSKSHD-HF 2336
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
+D +G + LD E ++ + V A DGG P S+ F
Sbjct: 2337 HVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNGNPPLFEQQ 2396
Query: 370 QYEVELAEDEPPGTPVVTLTATDADEDN--RLHYEITGGNTRGRFSITSQNGRGLITVAQ 427
YE ++E P G V + A DAD + +L Y I GN F I S G +IT++
Sbjct: 2397 IYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATG--IITLSN 2454
Query: 428 PLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTT 487
+ Y L +S +D RS T V + + N ++P F Y + E+AP+ T
Sbjct: 2455 LHRHALKPFYSLNLSVSDGVFRSST-QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTL 2513
Query: 488 VLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGY 547
V+ V TD D GI +TY + ++ + + +F IN + G I T + LDRET +
Sbjct: 2514 VMEVKTTDGDSGIYGHVTYHIVNDFAKD-------RFYIN-ERGQIFTLEKLDRETPAEK 2565
Query: 548 LLTVT--ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
+++V A+D G T V + + D NDN P F+ Y NI A GTSV + A
Sbjct: 2566 VISVRLMAKDAGGKVAFCT--VNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVK-SA 2622
Query: 606 TDADVGLNGRIHYELDPKDRE-EGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGT 664
+DAD G N I Y ++ + + I+ SGVI T ++L A+D G+
Sbjct: 2623 SDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS 2682
Query: 665 PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHY 724
P + S V+V++KI P F TF +SE+ P+GT I IRA E V++
Sbjct: 2683 PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPVGTEIDLIRA----EHSGTVLYS 2738
Query: 725 SIKGGD-DSN---SFSLETRQGSDKAELVTMVDLDYESPR-KKYELVIRAASPP--LWND 777
+KG +SN SF ++ + G K E LD+E+ + ++ ++ R +
Sbjct: 2739 LVKGNTPESNRDESFVIDRQSGRLKLEK----SLDHETTKWYQFSILARCTQDDHEMVAS 2794
Query: 778 VRVEILVTDVNDNAPVMK 795
V V I V D NDN+PV +
Sbjct: 2795 VDVSIQVKDANDNSPVFE 2812
Score = 216 bits (527), Expect = 1e-54
Identities = 215/787 (27%), Positives = 334/787 (42%), Gaps = 88/787 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEASV-------REGASSGTTVLTLKATDQDIGKNAEVEYTIE 63
+ +LD ND+ P F + Y+ + RE + + + ATD+D G NAE+ Y+IE
Sbjct: 1233 VKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYRVIATDKDEGPNAEISYSIE 1292
Query: 64 LVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVL-VKATDQ 122
F I+ ++G + ++ Y +L +KA D
Sbjct: 1293 -------------------DGNEHGKFFIEPKTGVVSSKRF---SAAGEYDILSIKAVDN 1330
Query: 123 ASPVSDRLSSTATIHVNIIDDNDNYPQ---FSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
P + SST +H+ I + F E +T +V E +PV I
Sbjct: 1331 GRP---QKSSTTRLHIEWISKPKQSLEPISFEESFFTFTVMES-----DPVAHMIGVISV 1382
Query: 180 DVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
+ + + I GGN F +D +G + + K LD EQ +Y L + A DG + +
Sbjct: 1383 EP-PGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG---TTTI 1438
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
TQ+ I + D ND+ P+F TS ++ + E+ I+++ A D DE +L YT+
Sbjct: 1439 LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSS 1496
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
++ +DP +G +YTS +LD E + L V D P + A
Sbjct: 1497 RDPLSLK-KFRLDPATGSLYTSEKLDHEAVSPAHLTVMVRDQDVPVKRNFARIVVNVSDT 1555
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLH--YEITGGNTRG-RFSITS 416
F Y+ + E G+ V+ +TA D D+ Y I GN S
Sbjct: 1556 NDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNIGNSFMI 1615
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPY 474
G I A+ LD + Y L V ATD G S+ V+I +T A+N +P F + Y
Sbjct: 1616 DPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY 1675
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
+ + E IG+ V +V+A + + Y + + +A F INP +G I
Sbjct: 1676 SVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDA-------FDINPHSGTII 1723
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T K LD ET+ Y L + + + LS T V + + D NDN PVF Q YT I E A
Sbjct: 1724 TQKALDFETLPIYTLIIQGTN--MAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESA 1781
Query: 595 LVGTSVSQ-------VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDR 647
+ + V + A DAD N + Y + + F ID ++G I T +LD
Sbjct: 1782 SINSVVLTDRNVPLVIRAADADKDSNALLVYHI-VEPSVHTYFAIDSSTGAIHTVLSLDY 1840
Query: 648 ESVATHDLKAVAIDGGTP----PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIG 703
E + D GTP ++ V VH + DIND PPVF + + G
Sbjct: 1841 EETSIFHFTVQVHDMGTPRLFAEYAANVTVH--VIDINDCPPVFAKPLYEASLLLPTYKG 1898
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKY 763
+ + A D D + + YSI G+ FS++ + G+ + T + R +Y
Sbjct: 1899 VKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQL-------RSRY 1951
Query: 764 ELVIRAA 770
EL +RA+
Sbjct: 1952 ELTVRAS 1958
Score = 202 bits (492), Expect = 2e-50
Identities = 170/574 (29%), Positives = 275/574 (47%), Gaps = 43/574 (7%)
Query: 103 ASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDED 162
A L+RE YT++VKA ++ + V R + V ++D ND P FS +Y+VS+ E+
Sbjct: 106 AILNREVKDHYTLIVKALEKNTNVEARTK----VRVQVLDTNDLRPLFSPTSYSVSLPEN 161
Query: 163 ISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRS 222
++ + IA++ ATDAD+G N Y+ T M F+I SG + L LDY + +
Sbjct: 162 TAIRTS--IARVSATDADIGTNGEFYYSF-KDRTDM-FAIHPTSGVIVLTGRLDYLETKL 217
Query: 223 YRLVIRAQDGG-----SPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIV 277
Y + I A D G S S+ +L ++I N+ AP S + P Y+IV
Sbjct: 218 YEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP-AYAIV 276
Query: 278 RVQAYDADEGVNAEL-TYTMTDKDYTGNVDLPITIDPRSGW-VYTSGQLDRETQA-KYQL 334
V D D+G N ++ + ++ D + + V G +D ++ Y L
Sbjct: 277 TVD--DCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGDIDWDSHPFGYNL 334
Query: 335 LVTATDGGDPPR-SATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDA 393
+ A D G PP+ S+ F Y E++E PP TPVV + A A
Sbjct: 335 TLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA 394
Query: 394 DEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTA 453
R ++ T G + +FS+ G LI++ +P+ +Q + L V+ +D R +
Sbjct: 395 YSHLRYVFKRTPG--KAKFSLNYNTG--LISILEPVKRQQAAHFELEVTTSD---RKAST 447
Query: 454 MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEIS 513
V + + AN+ P F Y A+ E+ PIGTT++ +SA D D G N +TYS+++
Sbjct: 448 KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTIMSLSAVDPDEGENGYVTYSIAN--- 504
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSG-YLLTVTARDGGVPSLSDTTDV-EISV 571
+H F I+ TGA++T++ LD E M Y L + A D G+P + + I++
Sbjct: 505 ----LNH-VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITL 559
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV 631
++NDN P+F++ I D VG ++ V A DAD + Y+++ E F
Sbjct: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIE-AGNELDLFS 616
Query: 632 IDPASGVIRTNKALD---RESVATHDLKAVAIDG 662
++P SGV+ ++L V+ H L+ A DG
Sbjct: 617 LNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDG 650
Score = 139 bits (337), Expect = 1e-31
Identities = 152/587 (25%), Positives = 250/587 (42%), Gaps = 39/587 (6%)
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
L+RE + Y L+V A + + T F P Y V L E+ T
Sbjct: 108 LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPL-FSPTSYSVSLPENTAIRT 166
Query: 384 PVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ ++ATDAD + + + F+I +G +I + LD+ + + Y + + A
Sbjct: 167 SIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG--VIVLTGRLDYLETKLYEMEILA 224
Query: 444 TDSG-------GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
D G G S A + ++I AN APV + S + P +V+ D
Sbjct: 225 ADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTVDDC 281
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS-GYLLTVTARD 555
D G N I SLS + + + + +D ++ GY LT+ A+D
Sbjct: 282 DQGANGDIA-SLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGDIDWDSHPFGYNLTLQAKD 340
Query: 556 GGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
G P S + ++ F++ +Y A I E A T V V A A L
Sbjct: 341 KGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHL-- 398
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
R ++ P + F ++ +G+I + + R+ A +L+ D ++ST ++
Sbjct: 399 RYVFKRTPG---KAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR----KASTKVL- 450
Query: 675 IKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS 734
+K+ N +PP F EN PIGTTI + A DPDEG N V YSI +
Sbjct: 451 VKVLGANSNPPEFTQTAYKAAFDENVPIGTTIMSLSAVDPDEGENGYVTYSI-ANLNHVP 509
Query: 735 FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVT----DVNDN 790
F+++ G+ + T +LDYE + Y L IRA+ L VE+L T ++NDN
Sbjct: 510 FAIDHFTGA----VSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDN 565
Query: 791 APVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
P+ + +D V A DAD +QY+I +GN +L LN +G ++
Sbjct: 566 TPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDLFSLNPNSGVLS 625
Query: 851 LSPQLNTNV-PKLA--TMEVSVTDGVNEIKAMMQLSVRLITEEMLLN 894
L L + K++ ++ ++ TDG N + +++ + L+N
Sbjct: 626 LKRSLMDGLGAKVSFHSLRITATDGEN-FATPLYINITVAASHKLVN 671
Score = 117 bits (282), Expect = 5e-25
Identities = 136/565 (24%), Positives = 238/565 (42%), Gaps = 68/565 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD ND P+F Y S+ E + T++ + ATD DIG N E Y+ + T
Sbjct: 136 RVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRT--- 192
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV--S 127
D+F I SG ++ LD + Y + + A D+ + S
Sbjct: 193 ------------------DMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGS 234
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVS-VDEDISVTDNPVIAKIKATDADVGANSA 186
+SS A + V+I N+ P + T + S +D D P A + D D GAN
Sbjct: 235 SGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD------PAYAIVTVDDCDQGANGD 288
Query: 187 I-RYAIIGGNTQMQF-SIDSLSGD----VSLVKTLDYE-QVRSYRLVIRAQDGGSPSRSN 239
I +I+ G+ QF ++ S G V + +D++ Y L ++A+D G+P + +
Sbjct: 289 IASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGDIDWDSHPFGYNLTLQAKDKGTPPQFS 348
Query: 240 TTQLL-INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD 298
+ +++ + +F +++ +SE P +V V+A A + L Y
Sbjct: 349 SVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA----YSHLRYVF-- 402
Query: 299 KDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
K G +++ +G + + R+ A ++L VT +D R A+
Sbjct: 403 KRTPGKA--KFSLNYNTGLISILEPVKRQQAAHFELEVTTSD-----RKASTKVLVKVLG 455
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN 418
F Y+ E+ P GT +++L+A D DE + + N +
Sbjct: 456 ANSNPPEFTQTAYKAAFDENVPIGTTIMSLSAVDPDEGENGYVTYSIANL-NHVPFAIDH 514
Query: 419 GRGLITVAQPLDFK-QERRYVLTVSATDSG---GRSDTAMVQINITDANNYAPVFENAPY 474
G ++ ++ LD++ R Y L + A+D G R + I + + N+ P+FE
Sbjct: 515 FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINC 574
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
++ D +G + VSA D+D Q+ E NE F +NP +G ++
Sbjct: 575 EGTIPRDLGVGEQITTVSAIDAD---ELQLV-QYQIEAGNEL-----DLFSLNPNSGVLS 625
Query: 535 TNK-LLD--RETMSGYLLTVTARDG 556
+ L+D +S + L +TA DG
Sbjct: 626 LKRSLMDGLGAKVSFHSLRITATDG 650
Score = 109 bits (261), Expect = 2e-22
Identities = 92/356 (25%), Positives = 164/356 (46%), Gaps = 23/356 (6%)
Query: 113 YTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIA 172
Y + ++A D+ +P + SS IHV +F + Y + E + + PV+
Sbjct: 332 YNLTLQAKDKGTP--PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISE-FAPPNTPVVM 388
Query: 173 KIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDG 232
+KA + A S +RY + +FS++ +G +S+++ + +Q + L + D
Sbjct: 389 -VKA----IPAYSHLRYVFKRTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSD- 442
Query: 233 GSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAEL 292
R +T++L+ + N N P F + ++ + ENVPIG +I+ + A D DEG N +
Sbjct: 443 ----RKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTIMSLSAVDPDEGENGYV 498
Query: 293 TYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAK-YQLLVTATDGGDP-PRSATA 350
TY++ + ++ +P ID +G V TS LD E + Y L + A+D G P R
Sbjct: 499 TYSIANLNH-----VPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEV 553
Query: 351 TXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG 410
F E + D G + T++A DADE + Y+I GN
Sbjct: 554 LATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELD 613
Query: 411 RFSITSQNGRGLITVAQPL-DFKQERRYVLTVSATDSGGRSDTAMVQINITDANNY 465
FS+ + G++++ + L D + ++ T + G + + INIT A ++
Sbjct: 614 LFSLNPNS--GVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASH 667
Score = 100 bits (240), Expect = 7e-20
Identities = 95/357 (26%), Positives = 161/357 (45%), Gaps = 22/357 (6%)
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+L+RE Y L V A + ++ T V + V+D ND P+F Y+ ++ E+ +
Sbjct: 107 ILNREVKDHYTLIVKALEKNT-NVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
TS+++V ATDAD+G NG +Y KDR + F I P SGVI LD ++++
Sbjct: 166 TSIARVSATDADIGTNGEFYYSF--KDRTD-MFAIHPTSGVIVLTGRLDYLETKLYEMEI 222
Query: 658 VAIDGGTPPQSSTVI-----VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
+A D G S+ I + + IE N+ PV + L+ + P +
Sbjct: 223 LAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTVD 279
Query: 713 DPDEGPNA-VVHYSIKGGDDSNSF-SLETRQGSDKAELVTMVDLDYESPRKKYELVIRA- 769
D D+G N + SI GD F ++ + GS + ++ + D+D++S Y L ++A
Sbjct: 280 DCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGDIDWDSHPFGYNLTLQAK 339
Query: 770 --ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF--PVGPFGRVPAYDADVTD 825
+PP ++ V+V I VT A +K + ++ F P P V A A
Sbjct: 340 DKGTPPQFSSVKV-IHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPA--YS 396
Query: 826 KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQL 882
L+Y LN TG +++ + +EV+ +D K ++++
Sbjct: 397 HLRYVFKRTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVLVKV 453
Score = 75.8 bits (178), Expect = 2e-12
Identities = 75/241 (31%), Positives = 111/241 (46%), Gaps = 34/241 (14%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VL N + P F Y+A+ E GTT+++L A D D G+N V Y+I L
Sbjct: 451 VKVLGANSNPPEFTQTAYKAAFDENVPIGTTIMSLSAVDPDEGENGYVTYSIA-----NL 505
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVAR-YTVLVKATDQASPVSDR 129
N F ID +GA+ T +LD E + R YT+ ++A+D P
Sbjct: 506 NHVP---------------FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRRE 550
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+ ATI +N + NDN P F + ++ D+ V + I + A DAD ++Y
Sbjct: 551 VEVLATITLNNL--NDNTPLFEKINCEGTIPRDLGVGEQ--ITTVSAIDAD--ELQLVQY 604
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLD---YEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I GN FS++ SG +SL ++L +V + L I A DG + T L IN
Sbjct: 605 QIEAGNELDLFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDG----ENFATPLYIN 660
Query: 247 I 247
I
Sbjct: 661 I 661
Score = 52.8 bits (121), Expect = 2e-05
Identities = 97/415 (23%), Positives = 146/415 (35%), Gaps = 58/415 (13%)
Query: 1310 CPEKRSRCSSAPCYNGAEC-SDLW-DTYICDCKEGHTGKDCADSTGPPWRFGGDGMLSFN 1367
CP C PC G+EC SD W + + C C G G+ C S+ G+ + +
Sbjct: 3789 CPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQ-CPGSSS--MTLTGNSYVKYR 3845
Query: 1368 PLLRPIQLPWLNALSIRTRQRDAFVM--------SIQLKSGLLHYSYN-GE---TMYLPM 1415
+L + +RT A VM +++ G L Y ++ G + +
Sbjct: 3846 LTENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVSVQS 3905
Query: 1416 ATLSDGAWHRIEIKWLGTDISVTVDYGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGL- 1474
++DG WH + ++ G + +D + T + GG G
Sbjct: 3906 IQVNDGQWHAVALEVNGNYARLVLDQ-VHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTR 3964
Query: 1475 --LASDVG-FFEGCIQDVRIGTAQSLLN-RPT----VRE--NVRDGC--QSRADCMLSIC 1522
+ VG F GC+ + + + LN +P + E +V GC + DC + C
Sbjct: 3965 HGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASNPC 4024
Query: 1523 PPYSKCVTS-WDSSTCTCEAGRVGPQC---VSACELGPC-GAARCVPDQTPKGYSCACEP 1577
C S C C A +G C V+ C PC CV D G+ C C
Sbjct: 4025 QNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSNPCLYGGTCVVDN--GGFVCQCRG 4082
Query: 1578 GYTLTTSGCIESGKEE-CPGGWWGGSACGPCACDVTRGYH-PHCNKENGKCHCKENHYKP 1635
YT K+E C G + C G+ C + +C
Sbjct: 4083 LYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDEC--------- 4133
Query: 1636 EGTAECLPCQCYAAGSENSSCEAATGQCHCRPGVIGRAC-DACANAYAEVTPNSG 1689
G PC + A EN+ + C+C GR C DA N Y N G
Sbjct: 4134 SGN----PC-LHGALCENTH---GSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIG 4180
>AY356402-1|AAR13653.1| 3222|Homo sapiens fat-like cadherin FATJ
protein protein.
Length = 3222
Score = 397 bits (977), Expect = e-109
Identities = 282/857 (32%), Positives = 427/857 (49%), Gaps = 73/857 (8%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
I N+LD ND+ P+F + Y S+ E G+TVL TD D G N+++ Y+I +
Sbjct: 226 IRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSI--AS 283
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
D+L F +D ++G L +LDRE + Y ++V+ D
Sbjct: 284 GDSLGQ-----------------FTVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQIP 325
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
+ R +STA + + ++D NDN P F T + E+ + + V+ K +ATD D G NS
Sbjct: 326 ASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPI--DTVVFKAQATDPDSGPNSY 382
Query: 187 IRYAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
I Y ++ GN +FSI ++ G+V L LD E+V +Y L + A D G PS S++T+++
Sbjct: 383 IEYTLLNPLGN---KFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVV 439
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + D+NDN P F +L++ ++EN G I++V A D DEG N ++ Y + + GN
Sbjct: 440 VMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN----GN 495
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ ID +G + + LDRE Y L V ATD G PR+ T+T
Sbjct: 496 TNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVP 555
Query: 365 XFMPGQYEVELAED--EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGR 420
F Y V + E+ P T ++ + A D D +++L Y + GGN F++++
Sbjct: 556 VFELSPYSVNVPENLGTLPRT-ILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSAS--- 611
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASV 478
G + V Q LD + + R+VL ++ATDSG + T IN+ D N+ P F + Y ++
Sbjct: 612 GELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTI 671
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
EDAP GT VL+V+A+D+D NA I + + QF INP TG I T+ L
Sbjct: 672 PEDAPTGTDVLLVNASDADASKNAVIR-----------IIGGNSQFTINPSTGQIITSAL 720
Query: 539 LDRETMSGYLLTVTARDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LDRET Y L V D G P LS +T V ++V DVNDN P F+ Y +I L G
Sbjct: 721 LDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPG 780
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
+ V V TDAD+G N +HY L ++ E+ F IDP G I L+ S T +
Sbjct: 781 SFVFAVTVTDADIGPNSELHYSLSGRNSEK--FHIDPLRGAIMAAGPLNGASEVTFSVHV 838
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
DGG+ P++ + V ++ + D P V + TF EN P+ + + I
Sbjct: 839 K--DGGSFPKTDSTTVTVRFVNKADFPKVRAKE-QTFMFPENQPVSSLVTTITGSSLRGE 895
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---PPL 774
P + Y I G+ N+F ++ G ++ LD+E +KY + I A PP
Sbjct: 896 P---MSYYIASGNLGNTFQIDQLTG----QVSISQPLDFEK-IQKYVVWIEARDGGFPPF 947
Query: 775 WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRIL 832
+ +++I V DVNDNAP+ K+ I ++ P V A D D +L Y I+
Sbjct: 948 SSYEKLDITVLDVNDNAPIFKEDPFISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIV 1006
Query: 833 SGNNANLILLNETTGSM 849
+GN N +N TG +
Sbjct: 1007 NGNMENSFSINHATGEI 1023
Score = 386 bits (951), Expect = e-106
Identities = 421/1648 (25%), Positives = 689/1648 (41%), Gaps = 184/1648 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND++P F Y E G+ V + ATD D G N +V Y I+
Sbjct: 1158 IFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIK------- 1210
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVA--------RYTVLVKATDQ 122
+ FRI+ +G + + L + V R++ +V ++D+
Sbjct: 1211 --------------SQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDR 1256
Query: 123 ASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVG 182
P L S T+ +NI+D NDN PQF + Y V +++ V +I D D G
Sbjct: 1257 GKP---SLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKV-GTKLIRVTAIDDKDFG 1312
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
NS + Y I N +F +D+ +G +S+ +L + +++ + + A+D G+P S+
Sbjct: 1313 LNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQAT 1372
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ I + + N + P F S ++ E+ IG + V A D D +N + Y+++ +
Sbjct: 1373 VHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSIS----S 1428
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
GN + I+ +G + + LD E K+++ ++A DGG R+ +
Sbjct: 1429 GNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDN 1488
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F+ Y + E+ P GT V+ L ATDAD T ++ + N G+
Sbjct: 1489 SPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPN-TGV 1547
Query: 423 ITVAQPLDFKQERRYVLTVSATD--SGGRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
IT LDF+ ++ Y LTV A + R A V I + N Y P F + Y + E
Sbjct: 1548 ITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISE 1607
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
AP GT V V A+D D+G + ++ Y + + F IN +TG I + +LD
Sbjct: 1608 AAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKG-------FQINKKTGQIYVSGILD 1660
Query: 541 RETMSGYLLTVTARD-GGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
RE L V A++ G + D V ++V+D ND P+F +Y+ I E +GT
Sbjct: 1661 REKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGT 1719
Query: 599 SVSQVGATDAD-VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
V+ V A D+D + R Y + E G+F I+P +G I LDRE++ ++L
Sbjct: 1720 HVTFVSAFDSDSIPSWSRFSYFIG-SGNENGAFSINPQTGQITVTAELDRETLPIYNLSV 1778
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
+A+D GTP + + + + +EDIND+ P+ + EN GT + +++ DPD
Sbjct: 1779 LAVDSGTPSATGSASLLVTLEDINDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDPDLP 1836
Query: 718 PNA--VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PP 773
PN +Y + G ++ FSL T L T ++D E Y V+ S P
Sbjct: 1837 PNQGPFTYYLLSTGPATSYFSLSTA-----GVLSTTREIDREQIADFYLSVVTKDSGVPQ 1891
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILS 833
+ + V I V D NDN + +I N Y + FP G G V D DV D + S
Sbjct: 1892 MSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDSFHCSLTS 1951
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNE-IKAMMQLSVRLITEEML 892
G +L + T + P+ L + DGV+ + + +++ + +
Sbjct: 1952 G-VTSLFSIPGGTCDLNSQPRSTDGTFDLTVLS---NDGVHSTVTSNIRVFFAGFSNATV 2007
Query: 893 LNSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFS 952
NSI +RL T + FL+ F+ ++ + + ++S ++ + T +
Sbjct: 2008 DNSILLRLGVPTVKDFLTNHYLHFLRIASSQLTGLGTAVQLYSAYEENNRTFLL------ 2061
Query: 953 ARRPDAEVGVAGDPSPHYSPTHLRERVYLHRTTLARLATVQVLPFDDNICVHEPCLNFEE 1012
V + + + +P+ + + L R + V+V D + CVH PC N
Sbjct: 2062 -------AAVKRNHNQYVNPSGVATFFESIKEILLRQSGVKVESVDHDSCVHGPCQNGGS 2114
Query: 1013 CLTVLKFGNASGFVNSDSVLFRPIYPVTSFTCQCPEGFTGVNCETILTKA---------- 1062
CL L + S V+ P+ F C+C G+ G CE + +
Sbjct: 2115 CLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECLPSPCHSGGT 2174
Query: 1063 --------SCEV-DG-DGSIC-RSGSQCV-ARREGGILCQ------GCSIDAAYTTAV-- 1102
SC DG G C R ++C+ + + G +CQ C YT
Sbjct: 2175 CHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSFNCVCKTGYTGVFGK 2234
Query: 1103 -CELRARSFPVSSFLTFPGLKRRHRIHLKLKFATQTTSGLLLYN--GRYNERHDFLALEL 1159
CEL + F S++ FP L + ++ +KFAT + LLLYN + +R +FLALE+
Sbjct: 2235 HCELNSYGFEELSYMEFPSLDPNNN-YIYVKFATIKSHALLLYNYDNQTGDRAEFLALEI 2293
Query: 1160 VSSEAGRGGGPGLRFSFSLGGGKSEITVEGNVGDGSWHTVEIEYFNRTITMILDDCDKVL 1219
LRFS++LG G ++T V DG +HTV ++ +D C +
Sbjct: 2294 AEER--------LRFSYNLGSGTYKLTTMKKVSDGHFHTVIARRAGMAASLTVDSCSENQ 2345
Query: 1220 SLAGAADFGLKYACANFTRKVLPARCEIPTETCHRFLDLTGPLQIGGLPNIPSSFQVKNK 1279
G ++T V P R T L LQ G V++
Sbjct: 2346 E-PGYCTVSNVAVSDDWTLDVQPNRV-----TVGGIRSLEPILQRRG--------HVESH 2391
Query: 1280 DFVGCISDFYIDHKFIDLNSYVADNGTLAGCPEKRSRCSSAPCYNGAECSDLWDTYICDC 1339
DFVGCI +F ++ + ++ + +A G L + S C+ +C + T D
Sbjct: 2392 DFVGCIMEFAVNGRPLEPSQALAAQGILDQYGDFISY-----CFKEKKCKKVCFTVTPDT 2446
Query: 1340 KEGHTGKDCAD---STGPPWRFGGDGMLSFNPLLRPIQLPWLNALSIRTRQRDAFVMSIQ 1396
GK D S + L +L P + L + RTR + ++ IQ
Sbjct: 2447 ALSLEGKGRLDYHMSQNEKREYLLRQSLR-GAMLEPFGVNSLE-VKFRTRSENGVLIHIQ 2504
Query: 1397 ---------LKSGLLHYSYN----GET-MYLPMATLSDGAWHRIEIKWLGTDISVTVD-- 1440
+K+G ++++ + G+ +P ++DG WH I GT ++VD
Sbjct: 2505 ESSNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDRI 2564
Query: 1441 YGLRTVLMPMLANKIQGQYIGKILIGGLDTTAGLLASDVGFFEGCIQDVRIG-------T 1493
Y R ++ P G + I +GG+ + F+GCI + G
Sbjct: 2565 YN-RDIIHP--TQDFGGLDVLTISLGGIPPNQAHRDAQTAGFDGCIASMWYGGESLPFSG 2621
Query: 1494 AQSLLNRPTVRENVRDGCQSRADCMLSICPPYSKCVTSWDSSTCTCEAGRVGPQCVSACE 1553
SL + +V+ GC+ C + C C+ W + C V P C
Sbjct: 2622 KHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWYAYRC------VPP---GDCA 2672
Query: 1554 LGPC-GAARCVPDQTPKGYSCACEPGYT 1580
PC C P G++C+C +T
Sbjct: 2673 SHPCQNGGSCEPG-LHSGFTCSCPDSHT 2699
Score = 371 bits (912), Expect = e-101
Identities = 283/876 (32%), Positives = 429/876 (48%), Gaps = 72/876 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I + D ND+ PVF + +V E G+ ++ L A D D G NA V YTI + AD
Sbjct: 25 EITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTI-ISGAD- 82
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
D FRID SG L+ LDRE+ ++Y++LV+A D
Sbjct: 83 ------------------DSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQ----- 119
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SS I++ + D ND+ P+FS Y+ + ED ++A I ATD D G N I Y
Sbjct: 120 -SSDMRINITVSDVNDHTPKFSRPVYSFDIPED--TIPGSLVAAILATDDDSGVNGEITY 176
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
+ + F ++ ++G +L + LDYE + Y L +RA+DGG + T ++ NI D
Sbjct: 177 IVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGG--GQFTTIRVYFNILD 234
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
VNDN P F + + S+ EN+P+G +++ DAD+G+N++LTY++ D G
Sbjct: 235 VNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQ----F 290
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRS---ATATXXXXXXXXXXXXXXF 366
T+D ++G + LDRE+Q+ Y L+V D P S +TA F
Sbjct: 291 TVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF 349
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG-RFSITSQNGRGLITV 425
+ + + E+ P T V ATD D + E T N G +FSI + +G + +
Sbjct: 350 LSPKL-TYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGE--VRL 406
Query: 426 AQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
LD ++ Y LTV ATD G S + V + + D N+ P+F A Y + E+
Sbjct: 407 TGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTL 466
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
GT ++ V A D D G N Q+ Y + + +N Q+F I+ TGAIT K LDRE
Sbjct: 467 TGTDIIQVFAADGDEGTNGQVRYGIVNGNTN-------QEFRIDSVTGAITVAKPLDREK 519
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMED-ALVGTSVSQ 602
Y LTV A D G +DT+ V I ++D+ND PVF+ Y+ N+ E+ + ++ Q
Sbjct: 520 TPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQ 579
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDG 662
V A D D G N ++ Y L E+ +F + ASG + ++LDRE+ L A D
Sbjct: 580 VVARDDDRGSNSKLSYVLF-GGNEDNAFTLS-ASGELGVTQSLDRETKERFVLMITATDS 637
Query: 663 GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
G+P + T +++ ++D+ND+ P F S I E++P GT + + A D D NAV+
Sbjct: 638 GSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVI 697
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI---RAASP-PLWNDV 778
I GG ++ F++ G +++T LD E+ + Y LV+ A SP PL +
Sbjct: 698 R--IIGG--NSQFTINPSTG----QIITSALLDRET-KDNYTLVVVCSDAGSPEPLSSST 748
Query: 779 RVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADV--TDKLQYRILSGNN 836
V + VTDVNDN P + + + P V DAD+ +L Y LSG N
Sbjct: 749 SVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYS-LSGRN 807
Query: 837 ANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
+ ++ G++ + LN T V V DG
Sbjct: 808 SEKFHIDPLRGAIMAAGPLNG--ASEVTFSVHVKDG 841
Score = 350 bits (861), Expect = 4e-95
Identities = 252/770 (32%), Positives = 374/770 (48%), Gaps = 48/770 (6%)
Query: 114 TVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAK 173
TV+ A P++ + + + + D NDN P F ++V+E+I D I +
Sbjct: 4 TVVAVGDTLAQPLA--AAEVFIVEITLQDINDNPPVFPTDMLDLTVEENIG--DGSKIMQ 59
Query: 174 IKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGG 233
+ A DAD GAN+ + Y II G F ID SGD+ + LD E+ Y L++RA DG
Sbjct: 60 LTAMDADEGANALVTYTIISGADD-SFRIDPESGDLIATRRLDRERRSKYSLLVRADDG- 117
Query: 234 SPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELT 293
+S+ ++ I + DVND+ P+F ++ + E+ G + + A D D GVN E+T
Sbjct: 118 --LQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEIT 175
Query: 294 YTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXX 353
Y + + D G L +P +G + LD E Q Y L V A DGG + T
Sbjct: 176 YIVNEDDEDGIFFL----NPITGVFNLTRLLDYEVQQYYILTVRAEDGGG--QFTTIRVY 229
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGR 411
F Y L E+ P G+ V+ TDAD+ +++L Y I G++ G+
Sbjct: 230 FNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQ 289
Query: 412 FSITSQNGRGLITVAQPLDFKQERRYVLTVSATD-----SGGRSDTAMVQINITDANNYA 466
F++ G++ V + LD + + Y L V D + + TA V I + D N+
Sbjct: 290 FTVDKN---GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNP 346
Query: 467 PVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
P F + P + E+ PI T V ATD D G N+ I Y+L + + N+ F I
Sbjct: 347 PTFLS-PKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK--------FSI 397
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLY 586
G + LDRE +S Y LTV A D G PSLS +T+V + V+D+NDN P+F Q LY
Sbjct: 398 GTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALY 457
Query: 587 TANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALD 646
I E+ L GT + QV A D D G NG++ Y + + + F ID +G I K LD
Sbjct: 458 KVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQ-EFRIDSVTGAITVAKPLD 516
Query: 647 RESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN-SPIGTT 705
RE T+ L A D G+ P++ T V I + DIND PVFE + + EN + T
Sbjct: 517 REKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT 576
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
I ++ A D D G N+ + Y + GG++ N+F+L S EL LD E+ ++++ L
Sbjct: 577 ILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL-----SASGELGVTQSLDRET-KERFVL 630
Query: 766 VIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDA 821
+I A SP L + ++V DVNDN P + F + P G V A DA
Sbjct: 631 MITATDSGSPALTGTGTINVIVDDVNDNVPTFAS-KAYFTTIPEDAPTGTDVLLVNASDA 689
Query: 822 DVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D + RI+ GN+ +N +TG + S L+ T+ V +D
Sbjct: 690 DASKNAVIRIIGGNSQ--FTINPSTGQIITSALLDRETKDNYTLVVVCSD 737
Score = 347 bits (853), Expect = 3e-94
Identities = 248/829 (29%), Positives = 406/829 (48%), Gaps = 48/829 (5%)
Query: 54 KNAEVEYTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARY 113
+N V + +T +L E + + F+ID +G + LD EK+ +Y
Sbjct: 876 ENQPVSSLVTTITGSSLRGEPMSYYIASGN--LGNTFQIDQLTGQVSISQPLDFEKIQKY 933
Query: 114 TVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAK 173
V ++A D P SS + + ++D NDN P F E + + E++S I
Sbjct: 934 VVWIEARDGGFPP---FSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRK---ILT 987
Query: 174 IKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGG 233
+ A D D G N + Y I+ GN + FSI+ +G++ V+ LD E+V Y L I++ D G
Sbjct: 988 VSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKG 1047
Query: 234 SPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELT 293
SPS+S + +++INI D NDNAPRF + +F V EN P+GY++ RV D D G+NA
Sbjct: 1048 SPSQSTSVKVMINILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISR 1106
Query: 294 YTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXX 353
Y++ D LP TI+P +G + S L+RE +Y++ V+A D G + +
Sbjct: 1107 YSIMD------ASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVT 1157
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGR 411
F Y ++ E G+ V + ATD DE + ++ Y I + R
Sbjct: 1158 IFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFR 1217
Query: 412 FSITSQN--GRGLITVAQPLDFKQE--RRYVLTVSATDSGGRS--DTAMVQINITDANNY 465
+ T+ + ++ F R+ V+++D G S V INI D+N+
Sbjct: 1218 INATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDN 1277
Query: 466 APVFENAPYTASVFEDAPIGTTVLVVSA-TDSDVGINAQITYSLSSEISNEAVAHHDQQF 524
AP F + Y V ++ +GT ++ V+A D D G+N+++ Y +S++ +H +F
Sbjct: 1278 APQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISND-------NHLGKF 1330
Query: 525 VINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQ 584
++ TG I+ L + + +TVTA+D G P LS V I+V + N + P F Q
Sbjct: 1331 KLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQS 1390
Query: 585 LYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA 644
+A I E +G+ V V A D D +NG I Y + EEG F I+ ++G++ KA
Sbjct: 1391 HMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSIS-SGNEEGIFAINSSTGILTLAKA 1449
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
LD E H++ AIDGG ++ V + + D+ND+ PVF SD + EN+P GT
Sbjct: 1450 LDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGT 1509
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
T+ + A D D G NAV+ Y+++ DS+ F ++ G + T LD+E+ ++ Y
Sbjct: 1510 TVIHLNATDADSGTNAVIAYTVQ-SSDSDLFVIDPNTG----VITTQGFLDFET-KQSYH 1563
Query: 765 LVIRAASPP---LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYD 820
L ++A + P + V I + N+ P ++ + + P G G V A D
Sbjct: 1564 LTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVS-KLYYFEISEAAPKGTIVGEVFASD 1622
Query: 821 ADV-TD-KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEV 867
D+ TD ++ Y I + +N+ TG + +S L+ + +++V
Sbjct: 1623 RDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKV 1671
Score = 345 bits (847), Expect = 2e-93
Identities = 256/887 (28%), Positives = 438/887 (49%), Gaps = 69/887 (7%)
Query: 4 PFCIHQQ--INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
PF +++ I VLD ND++P+F+ + + + E S +LT+ A D+D G N +++Y
Sbjct: 946 PFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSP-RKILTVSAMDKDSGPNGQLDY- 1003
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
E+V + +++ F I+ +G + + LDREKV+ Y + +K++D
Sbjct: 1004 -EIVNGN-----------------MENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSD 1045
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
+ SP S++ + +NI+D+NDN P+FS+ ++ V E+ + + ++ +D D+
Sbjct: 1046 KGSPSQ---STSVKVMINILDENDNAPRFSQ-IFSAHVPENSPL--GYTVTRVTTSDEDI 1099
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
G N+ RY+I+ + + F+I+ +GD+ + + L+ E YR+ + A D G + +T
Sbjct: 1100 GINAISRYSIM--DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVST 1154
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM-TDKD 300
+ I + D+NDNAPRF + + E IG + +V A D DEG N ++ Y + + +
Sbjct: 1155 DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE 1214
Query: 301 Y------TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
Y TG + + ++ +++ ++R + +VT++D G P + T
Sbjct: 1215 YFRINATTGEIFNKQILKYQNVTGFSNVNINR-----HSFIVTSSDRGKPSLISETTVTI 1269
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE---DNRLHYEITGGNTRGR 411
F+ +Y + ++ GT ++ +TA D + ++ + Y I+ N G+
Sbjct: 1270 NIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK 1329
Query: 412 FSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVF 469
F + N G I+VA L + + +TV+A D G S A V I +T+ N + P F
Sbjct: 1330 FKL--DNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEF 1387
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ +A++ E IG+ V VSA D D +N I YS+SS NE + F IN
Sbjct: 1388 SQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISS--GNE-----EGIFAINSS 1440
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
TG +T K LD E + +T++A DGG + + V ++V+DVNDN PVF Y
Sbjct: 1441 TGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPT 1500
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES 649
++E+A GT+V + ATDAD G N I Y + D + FVIDP +GVI T LD E+
Sbjct: 1501 VLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD--LFVIDPNTGVITTQGFLDFET 1558
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
++ L A + + S V+I+++ N+ P F S F ISE +P GT +GE+
Sbjct: 1559 KQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEV 1618
Query: 710 RAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
A D D G + VHY I G F + + G + + ++D + E R +++ +
Sbjct: 1619 FASDRDLGTDGEVHYLIFGNSRKKGFQINKKTG--QIYVSGILDREKEE-RVSLKVLAKN 1675
Query: 770 ASPPLWNDV-RVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGR-VPAYDADVT--- 824
D+ V + VT ++ N P + I + P+G V A+D+D
Sbjct: 1676 FGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSW 1735
Query: 825 DKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ Y I SGN +N TG +T++ +L+ + + V D
Sbjct: 1736 SRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVD 1782
Score = 338 bits (832), Expect = 1e-91
Identities = 252/802 (31%), Positives = 396/802 (49%), Gaps = 70/802 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
IN+LD ND++P F Q + A V E + G TV + +D+DIG NA Y+I D
Sbjct: 1059 INILDENDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSI----MDAS 1113
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F I+ +G ++ L+RE RY + V A D V
Sbjct: 1114 LP-----------------FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTV---- 1152
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+ TI V D NDN P+FS +Y + E + + ++ ATD D G+N + Y
Sbjct: 1153 STDVTIFVT--DINDNAPRFSRTSYYLDCPELTEIGSK--VTQVFATDPDEGSNGQVFYF 1208
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSY--------RLVIRAQDGGSPSRSNTTQ 242
I + F I++ +G++ + L Y+ V + ++ + D G PS + T
Sbjct: 1209 I--KSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETT 1266
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAY-DADEGVNAELTYTMTDKDY 301
+ INI D NDNAP+F S + V++NV +G ++RV A D D G+N+E+ Y +++ ++
Sbjct: 1267 VTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNH 1326
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
G L D +GW+ + L + + + VTA D G+PP S+ AT
Sbjct: 1327 LGKFKL----DNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENY 1382
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E G+ V T++A D D + + Y I+ GN G F+I S
Sbjct: 1383 HTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSST- 1441
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T+A+ LD++ +++ +T+SA D G R+ V +N+ D N+ +PVF + Y +
Sbjct: 1442 -GILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPT 1500
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+AP GTTV+ ++ATD+D G NA I Y++ S S+ FVI+P TG ITT
Sbjct: 1501 VLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD--------LFVIDPNTGVITTQG 1552
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LD ET Y LTV A + V I + N+ P F +LY I E A G
Sbjct: 1553 FLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKG 1612
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T V +V A+D D+G +G +HY + R++G F I+ +G I + LDRE LK
Sbjct: 1613 TIVGEVFASDRDLGTDGEVHYLIFGNSRKKG-FQINKKTGQIYVSGILDREKEERVSLKV 1671
Query: 658 VAIDGGT--PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+A + G+ V V++ + D ND PP+F + + ISE PIGT + + A D D
Sbjct: 1672 LAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSD 1730
Query: 716 EGPN-AVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYE-LVIRAASP 772
P+ + Y I G+++ +FS+ + G ++ +LD E+ P L + + +P
Sbjct: 1731 SIPSWSRFSYFIGSGNENGAFSINPQTG----QITVTAELDRETLPIYNLSVLAVDSGTP 1786
Query: 773 PLWNDVRVEILVTDVNDNAPVM 794
+ + + D+NDN P++
Sbjct: 1787 SATGSASLLVTLEDINDNGPML 1808
Score = 38.7 bits (86), Expect = 0.30
Identities = 14/33 (42%), Positives = 18/33 (54%), Gaps = 1/33 (3%)
Query: 1317 CSSAPCYNGAECSD-LWDTYICDCKEGHTGKDC 1348
C+S PC NG C L + C C + HTG+ C
Sbjct: 2671 CASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTC 2703
Score = 34.3 bits (75), Expect = 6.4
Identities = 17/50 (34%), Positives = 24/50 (48%), Gaps = 7/50 (14%)
Query: 1040 TSFTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILC 1089
+ FTC CP+ TG CE ++ +C G +C G C A G +C
Sbjct: 2688 SGFTCSCPDSHTGRTCEMVV---ACL----GVLCPQGKVCKAGSPAGHVC 2730
>AL772287-2|CAI13626.1| 3359|Homo sapiens cadherin-like 23 protein.
Length = 3359
Score = 355 bits (873), Expect = 1e-96
Identities = 274/879 (31%), Positives = 425/879 (48%), Gaps = 59/879 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+N+LD ND+ P F+ + A V EG +G ++ + A D D G N V Y + V +
Sbjct: 883 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP-VGMPRM 941
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F I+ SG ++T LDRE++A Y + V A+D +P
Sbjct: 942 D------------------FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK--- 980
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SST+T+ ++++D ND P F Y VSV ED+ + + TD DVG N+ + Y
Sbjct: 981 SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR--VVWLNCTDNDVGLNAELSYF 1038
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR--SNTTQLLINIR 248
I GGN +FS+ V V LD E +Y L++ A D G + + T + + +
Sbjct: 1039 ITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL 1098
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F S ++ SV E++P G+SI++++A DADEG + Y + ++ N +
Sbjct: 1099 DVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIH 1158
Query: 309 ITIDPRSGWVYTSGQ-LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++ +G + + LDRE + + L+V A + P ++ F
Sbjct: 1159 VS----NGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT 1214
Query: 368 PGQY-EVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
QY + L E GT V+ + ATD D + ++Y I G G+F I GLI
Sbjct: 1215 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEI--DESTGLII 1271
Query: 425 VAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDAN--NYAPVFENAPYTASVFEDA 482
LD++ + Y++ VSATD + + IT N + A F NA Y A++ E+
Sbjct: 1272 TVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENL 1331
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
+GT ++ V A D +N QITY ++ S +A A F I+ TG IT L+DRE
Sbjct: 1332 ALGTEIVRVQAYSID-NLN-QITYRFNAYTSTQAKA----LFKIDAITGVITVQGLVDRE 1385
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA-NIMEDALVGTSVS 601
Y LTV A DGG P + T V I+V+D NDN P F +A +I ED VG V+
Sbjct: 1386 KGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVA 1444
Query: 602 QVGATDADVGLNGRIHYELDPKDREEGSFVI---DPASGVIRTNKALDRESVATHDLKAV 658
V A D D G NG++ + L G+F I + + G + + LDRE + + L+ V
Sbjct: 1445 TVKAWDPDAGSNGQVVFSL-ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVV 1503
Query: 659 AIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC-LTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP+ I+ + I DIND+PPV ES ++EN GT + ++RA D D G
Sbjct: 1504 ASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIG 1563
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
N+V+ Y I G+ +F ++ R + A D + +S V +P L
Sbjct: 1564 INSVLSYYITEGNKDMAFRMD-RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSAT 1622
Query: 778 VRVEILVTDVNDNAPVMKD--FQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILS 833
V + + D NDNAP+ + ++++ + D + A D D + Y I++
Sbjct: 1623 THVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEGPNGTVTYAIVA 1681
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPK-LATMEVSVTD 871
GN N ++ G +T + +L+ + T+ V+ TD
Sbjct: 1682 GNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATD 1720
Score = 350 bits (861), Expect = 4e-95
Identities = 274/832 (32%), Positives = 400/832 (48%), Gaps = 85/832 (10%)
Query: 10 QINVLDCNDHSPVFEMQ-QYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
Q+ +LD ND+ PV E Y SV E GT V+ ++ATD+DIG N+ + Y I D
Sbjct: 1519 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1578
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS 127
FR+D SG + TR A DRE+ + Y ++ D+ +P
Sbjct: 1579 M-------------------AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT- 1618
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS+T ++V I+D+NDN P F + Y V +DE + +I I+A D D G N +
Sbjct: 1619 --LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-IQALDLDEGPNGTV 1675
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRS-YRLVIRAQDGG---SPSRSNTTQL 243
YAI+ GN F ID G ++ K LDYE Y L++ A D S ++TT +
Sbjct: 1676 TYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1735
Query: 244 LINIRDVNDNAPRF---YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKD 300
L+N+ D+NDN P F Y F+ V+E P G + A+D D G N ++ Y++ D D
Sbjct: 1736 LVNVNDINDNVPTFPRDYEGPFE--VTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGD 1792
Query: 301 YTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
G I P G V +LDRET A Y L + A D G PP S+T
Sbjct: 1793 PLGE----FVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLD 1848
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITS 416
+ + ++E+ P + V + A+DAD + RL + IT GN F I +
Sbjct: 1849 INDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINA 1908
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG-----GRSDTAMVQINITDANNYAPVFEN 471
G ++TV +PLD ++ Y LT+S D+ R D ++ I ++D N+ P+F
Sbjct: 1909 TTG--IVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1966
Query: 472 APYTASVFEDAPIGTTVLVVS----ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ Y A V E++P GT + V++ A D+D I A +TY L S F IN
Sbjct: 1967 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG--------LFDIN 2018
Query: 528 PQTGAITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
TG +T ++DRE S +L + + L+ T + I+++D NDN P F
Sbjct: 2019 SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPAT 2078
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRT-NKA 644
T +++E+ G SV QV ATD D GLNG + Y ++ ++ F+I +GVIR N
Sbjct: 2079 LTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR--FLIHLVTGVIRVGNAT 2136
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
+DRE ++ L VA D GT P S T IV I I+DINDS P F + T + E++ GT
Sbjct: 2137 IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGT 2196
Query: 705 TIGEIRAHDPDEGPNAVVH-YSIKGGDDS--------NSFSLETRQGS------DKAELV 749
I I A D D P H I DD+ ++F++ GS ELV
Sbjct: 2197 VIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELV 2256
Query: 750 TMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIF 801
++ +L R+ S P + ++ + V DVNDN P K F I +
Sbjct: 2257 ATYEVTLSVIDNASDLPERSVSVP---NAKLTVNVLDVNDNTPQFKPFGITY 2305
Score = 347 bits (852), Expect = 5e-94
Identities = 267/859 (31%), Positives = 406/859 (47%), Gaps = 51/859 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND+ P ++ Y ++ E + V T+ A D D+G+N + Y+I+
Sbjct: 771 ITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ------- 823
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P + ++ + R A L R+ ++V TD P +
Sbjct: 824 -PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK------IVVSVTDCGRPPL-KA 875
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+AT+ VN++D NDN P F + V E I + I ++ A D D G N + Y
Sbjct: 876 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVS--IYQVVAIDLDEGLNGLVSYR 933
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ G +M F I+S SG V LD E++ Y+L + A D G+P++S+T+ L I++ DV
Sbjct: 934 MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDV 993
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
ND P F+ +++ SVSE+VP + +V + D D G+NAEL+Y +T GNVD +
Sbjct: 994 NDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG----GNVDGKFS 1049
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR--SATATXXXXXXXXXXXXXXFMP 368
+ R V T LDRET A Y L++ A D G + + TAT F+
Sbjct: 1050 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1109
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRGLITVA 426
YE + ED P G ++ L ATDADE R+ Y I GN F I NG L+
Sbjct: 1110 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGL-LMRGP 1168
Query: 427 QPLDFKQERRYVLTVSA--TDSGGRSDTAMVQINITDANNYAPVFENAPYT-ASVFEDAP 483
+PLD ++ +VL V A D G + V + + D N+ APVF Y+ + E A
Sbjct: 1169 RPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1228
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
IGT+V+VV ATD D G + Y + S + +F I+ TG I T LD ET
Sbjct: 1229 IGTSVIVVQATDRDSGDGGLVNYRILSGA--------EGKFEIDESTGLIITVNYLDYET 1280
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y++ V+A D P V I++++ D F Y A I+E+ +GT + +V
Sbjct: 1281 KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRV 1340
Query: 604 GATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAID 661
A D LN +I Y + + + F ID +GVI +DRE + L VA D
Sbjct: 1341 QAYSID-NLN-QITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADD 1398
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFE-SDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
GG P STV V+I + D ND+ P F+ + I E+ P+G + ++A DPD G N
Sbjct: 1399 GG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNG 1457
Query: 721 VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V +S+ G+ + +F + T S E+ LD E Y L + A+ +PP D
Sbjct: 1458 QVVFSLASGNIAGAFEIVTTNDS-IGEVFVARPLDREE-LDHYILQVVASDRGTPPRKKD 1515
Query: 778 VRVEILVTDVNDNAPVMKD---FQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSG 834
+++ + D+NDN PV++ + + N R D + L Y I G
Sbjct: 1516 HILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEG 1575
Query: 835 NNANLILLNETTGSMTLSP 853
N ++ +G + P
Sbjct: 1576 NKDMAFRMDRISGEIATRP 1594
Score = 338 bits (831), Expect = 2e-91
Identities = 266/889 (29%), Positives = 409/889 (46%), Gaps = 75/889 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 452 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 505
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 506 ---DD------------PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 546
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 547 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 602
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 603 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 662
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 663 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSL 718
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DG G ++ AT
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTG 836
Query: 420 R-----GLITVAQPLDFKQERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFE 470
+ ++ P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 837 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 896
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 897 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSS 949
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 950 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1009
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESV 650
ED V + TD DVGLN + Y + +G F + V+RT LDRE+
Sbjct: 1010 SEDVPREFRVVWLNCTDNDVGLNAELSYFI-TGGNVDGKFSVGYRDAVVRTVVGLDRETT 1068
Query: 651 ATHDLKAVAIDGGT--PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A + L AID G + T V + + D+ND+ P+F + E+ P G +I +
Sbjct: 1069 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1128
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
++A D DEG V Y I G+ N+F + G + LD E + L++
Sbjct: 1129 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG---LLMRGPRPLDRER-NSSHVLIVE 1184
Query: 769 AAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVT 824
A + P+ + VRV + V D+ND APV Q ++ +G V A D D
Sbjct: 1185 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1244
Query: 825 D--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D + YRILSG ++E+TG + L+ M VS TD
Sbjct: 1245 DGGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATD 1292
Score = 336 bits (825), Expect = 9e-91
Identities = 274/889 (30%), Positives = 419/889 (47%), Gaps = 83/889 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASS-GTTVLTLKATDQDIGKNAEVEYTIELVT 66
H + ++D ND++P+F+ YE + EG + T+++T++A D D G N V Y I V
Sbjct: 1624 HVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI--VA 1681
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDRE-KVARYTVLVKATDQASP 125
+ +N FRID G + LD E RYT++V ATDQ
Sbjct: 1682 GNIVN-----------------TFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPI 1724
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+S RL+ST T+ VN+ D NDN P F + Y E P + A D D G N
Sbjct: 1725 LSHRLTSTTTVLVNVNDINDNVPTF-PRDYE-GPFEVTEGQPGPRVWTFLAHDRDSGPNG 1782
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQL 243
+ Y+I+ G+ +F I + G + + K LD E + Y L I A+D G P S+T +
Sbjct: 1783 QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLV 1842
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D+NDN P ++SEN P+ + V A DAD G NA LT+ +T G
Sbjct: 1843 GIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT----AG 1898
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
N + I+ +G V + LDRE +Y+L ++ D + PR A
Sbjct: 1899 NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDEN 1958
Query: 364 X---XFMPGQYEVELAEDEPPGTPVVTLT----ATDADED--NRLHYEITGGNTRGRFSI 414
F Y+ E+ E+ P GTP+ L A DAD+D + Y++ G + G F I
Sbjct: 1959 DNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS-GLFDI 2017
Query: 415 TSQNGRGLITVAQPLDFKQER----RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE 470
S G++TV + +E L + A D G + TA + I I D N+ P F
Sbjct: 2018 NSST--GVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2075
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
A T + E+ P G +VL V+ATD D G+N ++ Y + EA A +F+I+ T
Sbjct: 2076 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGA--QDRFLIHLVT 2127
Query: 531 GAITT-NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
G I N +DRE Y LTV A D G LS T V I + D+ND+ P F + T +
Sbjct: 2128 GVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVS 2187
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYEL------DPKDR----EEGSFVIDPASGVI 639
++E A GT ++ + A D D LN ++ Y + D DR +E +F ++ +G +
Sbjct: 2188 VLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSV 2245
Query: 640 RTNKALDRESVATHDLKAVAIDGGTP-PQSSTVIVHIKIE----DINDSPPVFESDCLTF 694
++RE VAT+++ ID + P+ S + + K+ D+ND+ P F+ +T+
Sbjct: 2246 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2305
Query: 695 Y---ISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
Y I E + GTT+ + A DPD+G N +V Y++ LE S +++
Sbjct: 2306 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE---DSSAGKVIAN 2362
Query: 752 VDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
+DYE +RA+ SPP ++ V + + D+NDN P+ ++D
Sbjct: 2363 RTVDYEEVH-WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFED-V 2420
Query: 809 PVGP-FGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
PVG V A DAD + G+ + +N TTG + + L+
Sbjct: 2421 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2469
Score = 330 bits (811), Expect = 4e-89
Identities = 278/882 (31%), Positives = 411/882 (46%), Gaps = 62/882 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ P+F YEASV E G ++L LKATD D G+ V Y I L
Sbjct: 1095 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI-------L 1147
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRAS-LDREKVARYTVLVKATDQASPVSDR 129
+ FRI +G L+ LDRE+ + + ++V+A +
Sbjct: 1148 HGNHGNN------------FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL---GP 1192
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYT-VSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ S+ + V + D ND P F+++ Y+ + + E + + ++ ++ATD D G +
Sbjct: 1193 MRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIV--VQATDRDSGDGGLVN 1250
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y I+ G + +F ID +G + V LDYE SY + + A D P + I +
Sbjct: 1251 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLL 1309
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
+ D A +F + ++ ++ EN+ +G IVRVQAY D +N ++TY T L
Sbjct: 1310 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN-LN-QITYRFNAYTSTQAKAL- 1366
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
ID +G + G +DRE Y L V A DGG S
Sbjct: 1367 FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFT 1426
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR-GLITV 425
V + ED P G V T+ A D D + ++ + + GN G F I + N G + V
Sbjct: 1427 SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFV 1486
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENA-PYTASVFEDA 482
A+PLD ++ Y+L V A+D G R ++Q+ I D N+ PV E+ Y SV E+
Sbjct: 1487 ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1546
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL-DR 541
GT V+ V ATD D+GIN+ ++Y ++ + D F ++ +G I T DR
Sbjct: 1547 GGGTAVVQVRATDRDIGINSVLSYYITE-------GNKDMAFRMDRISGEIATRPAPPDR 1599
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA-LVGTSV 600
E S Y L T D G P+LS TT V +++VD NDN P+F+Q Y + E + TS+
Sbjct: 1600 ERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSL 1659
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE-SVATHDLKAVA 659
+ A D D G NG + Y + +F ID GVI K LD E S + L A
Sbjct: 1660 ITIQALDLDEGPNGTVTYAI-VAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTA 1718
Query: 660 IDGG---TPPQSSTVIVHIKIEDINDSPPVFESDCL-TFYISENSPIGTTIGEIRAHDPD 715
D + +ST V + + DIND+ P F D F ++E P G + AHD D
Sbjct: 1719 TDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRD 1777
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---P 772
GPN V YSI GD F + +G + V+LD E+ Y L I A P
Sbjct: 1778 SGPNGQVEYSIMDGDPLGEFVISPVEGVLRVR--KDVELDRETIAF-YNLTICARDRGMP 1834
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDAD--VTDKLQY 829
PL + + V I V D+NDN PV+ + + ++ PV F V A DAD +L +
Sbjct: 1835 PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENS-PVSSFVAHVLASDADSGCNARLTF 1893
Query: 830 RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
I +GN +N TTG +T++ L+ + +SV D
Sbjct: 1894 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1935
Score = 327 bits (803), Expect = 4e-88
Identities = 273/868 (31%), Positives = 416/868 (47%), Gaps = 76/868 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +L+ D + F YEA++ E + GT ++ ++A Y+I D L
Sbjct: 1306 ITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQA------------YSI-----DNL 1348
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N + + +F+ID +G + + +DREK YT+ V A D P ++
Sbjct: 1349 N-QITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGP---KV 1403
Query: 131 SSTATIHVNIIDDNDNYPQFS-EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
ST +++ ++D+NDN P+F VS+ ED V +A +KA D D G+N + +
Sbjct: 1404 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQR--VATVKAWDPDAGSNGQVVF 1461
Query: 190 AIIGGNTQMQFSI----DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
++ GN F I DS+ G+V + + LD E++ Y L + A D G+P R L +
Sbjct: 1462 SLASGNIAGAFEIVTTNDSI-GEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQV 1520
Query: 246 NIRDVNDNAPRFYTSL-FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
I D+NDN P + + SV+ENV G ++V+V+A D D G+N+ L+Y +T+ GN
Sbjct: 1521 TILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE----GN 1576
Query: 305 VDLPITIDPRSGWVYTS-GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
D+ +D SG + T DRE Q+ Y L+ T D G P SAT
Sbjct: 1577 KDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNA 1636
Query: 364 XXFMPGQYEVELAED-EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGR 420
F YEV L E + T ++T+ A D DE + + Y I GN F I
Sbjct: 1637 PMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH--M 1694
Query: 421 GLITVAQPLDFK-QERRYVLTVSATD-----SGGRSDTAMVQINITDANNYAPVFEN--- 471
G+IT A+ LD++ RY L V+ATD S + T V +N+ D N+ P F
Sbjct: 1695 GVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYE 1754
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
P+ V E P G V A D D G N Q+ YS+ + + + +FVI+P G
Sbjct: 1755 GPF--EVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSI---MDGDPLG----EFVISPVEG 1804
Query: 532 AITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
+ K LDRET++ Y LT+ ARD G+P LS T V I V+D+NDN+PV
Sbjct: 1805 VLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNIT 1864
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES 649
I E++ V + V+ V A+DAD G N R+ + + +RE +F I+ +G++ N+ LDRE
Sbjct: 1865 ISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRER-AFFINATTGIVTVNRPLDRER 1923
Query: 650 VATHDLKAVAIDGGTPPQSSTV---IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
+ + L D P+ + ++ I + D ND+ P+F + ENSP GT +
Sbjct: 1924 IPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPL 1983
Query: 707 ----GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKK 762
G I A D D+ AVV Y + G S F + + G ++D + SP
Sbjct: 1984 TVLNGPILALDADQDIYAVVTYQLLGAQ-SGLFDINSSTGVVTVRSGVIIDREAFSP-PI 2041
Query: 763 YELVIRAASPPLWNDV-RVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
EL++ A L N + I + D NDN P + + ++C P +V A D
Sbjct: 2042 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2101
Query: 822 D--VTDKLQYRILSGNNANLILLNETTG 847
D + +L YRI +G + L++ TG
Sbjct: 2102 DSGLNGELVYRIEAGAQ-DRFLIHLVTG 2128
Score = 318 bits (780), Expect = 2e-85
Identities = 267/872 (30%), Positives = 418/872 (47%), Gaps = 77/872 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEA-SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+ V D ND +PVF QQY +RE A GT+V+ ++ATD+D G V Y I
Sbjct: 1201 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI------- 1253
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ F ID +G ++T LD E Y + V ATDQA P +
Sbjct: 1254 -------------LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG 1300
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S +++ ++++ D QFS +Y ++ E++++ I +++A D R+
Sbjct: 1301 FCS---VYITLLNELDEAVQFSNASYEAAILENLALGTE--IVRVQAYSIDNLNQITYRF 1355
Query: 190 -AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
A + F ID+++G +++ +D E+ Y L + A DGG P +T ++ I +
Sbjct: 1356 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVL 1414
Query: 249 DVNDNAPRF-YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D NDN+PRF +TS S+ E+ P+G + V+A+D D G N ++ +++ + G ++
Sbjct: 1415 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1474
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF- 366
+T + G V+ + LDRE Y L V A+D G PPR
Sbjct: 1475 -VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIE 1533
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLIT 424
P Y V + E+ GT VV + ATD D ++ L Y IT GN F + +G + T
Sbjct: 1534 SPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE-IAT 1592
Query: 425 VAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
P D +++ Y L + D G S T V + I D N+ AP+F+ P+ + ++
Sbjct: 1593 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ-PHYEVLLDEG 1651
Query: 483 P--IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
P + T+++ + A D D G N +TY++ ++ V F I+ G IT K LD
Sbjct: 1652 PDTLNTSLITIQALDLDEGPNGTVTYAI---VAGNIV----NTFRIDRHMGVITAAKELD 1704
Query: 541 RETMSG-YLLTVTARDGGVPSLS----DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
E G Y L VTA D P LS TT V ++V D+NDN P F + + +
Sbjct: 1705 YEISHGRYTLIVTATDQ-CPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQ 1763
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNK--ALDRESVATH 653
G V A D D G NG++ Y + D G FVI P GV+R K LDRE++A +
Sbjct: 1764 PGPRVWTFLAHDRDSGPNGQVEYSIMDGD-PLGEFVISPVEGVLRVRKDVELDRETIAFY 1822
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
+L A D G PP SST++V I++ DIND+ PV + + ISENSP+ + + + A D
Sbjct: 1823 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1882
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM-VDLDYESPRKKYELVIRAASP 772
D G NA + ++I G+ +F + G +VT+ LD E +Y+L I
Sbjct: 1883 ADSGCNARLTFNITAGNRERAFFINATTG-----IVTVNRPLDRER-IPEYKLTISVKDN 1936
Query: 773 PLWNDVR------VEILVTDVNDNAPVM--KDFQI-IFNNYKDCFPV----GPFGRVPAY 819
P + + I ++D NDN P+ +Q + N P+ GP + A
Sbjct: 1937 PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA- 1995
Query: 820 DADVTDKLQYRILSGNNANLILLNETTGSMTL 851
D D+ + Y++L G + L +N +TG +T+
Sbjct: 1996 DQDIYAVVTYQLL-GAQSGLFDINSSTGVVTV 2026
Score = 305 bits (750), Expect = 1e-81
Identities = 256/901 (28%), Positives = 414/901 (45%), Gaps = 58/901 (6%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 553 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 610
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTV--LVKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 611 FG-------------SYFDISLYEG-YGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-- 654
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 655 -PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 711
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 712 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 771
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM--TDKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 772 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 831
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 832 N-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 890
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +
Sbjct: 891 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS- 949
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 950 -GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1008
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V ED P V+ ++ TD+DVG+NA+++Y ++ + D +F + + + T
Sbjct: 1009 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITG-------GNVDGKFSVGYRDAVVRTVV 1061
Query: 538 LLDRETMSGYLLTVTARDGGVPSL--SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
LDRET + Y+L + A D G + T V ++V+DVNDN P+F Q Y A++ ED
Sbjct: 1062 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIP 1121
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVI-RTNKALDRESVATHD 654
G S+ Q+ ATDAD G GR+ Y + +F I ++G++ R + LDRE ++H
Sbjct: 1122 EGHSILQLKATDADEGEFGRVWYRI-LHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1180
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-ESDCLTFYISENSPIGTTIGEIRAHD 713
L A + P S+V V + +EDIND PVF + + E + IGT++ ++A D
Sbjct: 1181 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATD 1240
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPP 773
D G +V+Y I G + F ++ G ++T+ LDYE+ V P
Sbjct: 1241 RDSGDGGLVNYRILSGAE-GKFEIDESTGL----IITVNYLDYETKTSYMMNVSATDQAP 1295
Query: 774 LWNDVRVEILVTDVN--DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRI 831
+N + +T +N D A + ++ RV AY D +++ YR
Sbjct: 1296 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRF 1355
Query: 832 ---LSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLIT 888
S L ++ TG +T+ ++ T+ V DG ++ + +++ + ++
Sbjct: 1356 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLD 1415
Query: 889 E 889
E
Sbjct: 1416 E 1416
Score = 295 bits (725), Expect = 1e-78
Identities = 238/779 (30%), Positives = 370/779 (47%), Gaps = 71/779 (9%)
Query: 15 DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPED 74
D ND P F SV E A GT + + A D D+ N ++EY I + A +D
Sbjct: 2171 DINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAK----DD 2224
Query: 75 AXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSST- 133
+D F ++ +G+++ ++ ++RE VA Y V + D AS + +R S
Sbjct: 2225 TDRLVPNQ----EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2280
Query: 134 -ATIHVNIIDDNDNYPQFSEKTYTVSVDEDIS-VTDNPVIAKIKATDADVGANSAIRYAI 191
A + VN++D NDN PQF T ++ + T + + A D D G N + Y +
Sbjct: 2281 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 2340
Query: 192 IG----GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ G Q++ DS +G V +T+DYE+V +RA D GSP R+ + + I
Sbjct: 2341 LDLVPPGYVQLE---DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 2397
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D+NDN P F +QE+V E+VP+G I+ V A DAD G A + Y++ G+ +
Sbjct: 2398 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL------GDGES 2451
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG-GDPP---RSATATXXXXXXXXXXXX 363
I+P +G +Y LDRE + Y L A D GD R +
Sbjct: 2452 KFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCR 2511
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F Q+ + E+EP GT V+T+ ATD DE + L Y + G F + + G
Sbjct: 2512 PQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDS--G 2568
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAP--YTAS 477
L+T +PL + ++ LTV ATD G T M+ + + D N+ PVF P
Sbjct: 2569 LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILH 2626
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ P+ + V V ATD D G+N + YS N + F+I+P +G I T +
Sbjct: 2627 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGN----RDWEFFIIDPISGLIQTAQ 2682
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVF------KQQLYTANI 590
LDRE+ + Y L + A D G P +T +++++ D++DNEP+F Q +
Sbjct: 2683 RLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2742
Query: 591 MEDALVGTSVSQV-GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALD--R 647
E + GT V V GA DAD G N ++Y + EE +F + P G + + LD R
Sbjct: 2743 PEHSPRGTLVGNVTGAVDADEGPNAIVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDRER 2800
Query: 648 ESVATHDLKAVAIDGGTPPQ--SSTV---------IVHIKIEDINDSPPVFESDCLTFYI 696
E++ + +KA + TPP+ S T+ V + +EDIND PP F T +
Sbjct: 2801 EAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2860
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD 755
+ ++ +G+ + ++ A D D G N++V YSI + F D ++ TM +D
Sbjct: 2861 ATDAKVGSELIQVLALDADIGNNSLVFYSILA---IHYFRALANDSEDVGQVFTMGSMD 2916
Score = 287 bits (703), Expect = 5e-76
Identities = 247/820 (30%), Positives = 373/820 (45%), Gaps = 85/820 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ PV ++ E + + V + A+D D G NA + + I TA
Sbjct: 1844 IRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAG-- 1898
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N E A F I+ +G + LDRE++ Y + + D +P + R+
Sbjct: 1899 NRERA--------------FFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPRI 1942
Query: 131 SSTA--TIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIA---KIKATDADVGANS 185
+ + + + D+NDN+P F++ TY V E+ S P+ I A DAD +
Sbjct: 1943 ARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMEN-SPAGTPLTVLNGPILALDADQDIYA 2001
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRS--YRLVIRAQDGGSPSRSNTT 241
+ Y ++G + + F I+S +G V++ +D E L++ A+D G ++T
Sbjct: 2002 VVTYQLLGAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTA 2058
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
LLI I D NDN P F + + EN P G+S+++V A D D G+N EL Y +
Sbjct: 2059 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ 2118
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+ +T R G + +DRE Q Y+L V ATD G P S TA
Sbjct: 2119 DRFLIHLVTGVIRVG----NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIND 2174
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITG-----------GNTRG 410
F+ V + E PGT + +TA D D + +L Y I G N
Sbjct: 2175 SRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQED 2234
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG----RS---DTAMVQINITDAN 463
F++ G + V P++ + Y +T+S D+ RS A + +N+ D N
Sbjct: 2235 AFAVNINTGS--VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVN 2292
Query: 464 NYAPVFEN---APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH 520
+ P F+ Y + E A GTT++ V+A D D G+N +TY+L + V
Sbjct: 2293 DNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2352
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
D G + N+ +D E + TV A D G P + V + +VD+NDN P+
Sbjct: 2353 DSS------AGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPI 2406
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR 640
F Q Y + ED VGT + V ATDAD G I Y L E F I+P +G I
Sbjct: 2407 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG---ESKFAINPTTGDIY 2463
Query: 641 TNKALDRESVATHDLKAVAIDG----GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYI 696
+LDRE + L A+A D + + ++V V I++ D+ND P F + +
Sbjct: 2464 VLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSV 2523
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDY 756
EN P GT++ + A D DEGPN + YS++G +F ++ G LVT
Sbjct: 2524 YENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEAFHVDMDSG-----LVT-TQRPL 2576
Query: 757 ESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPV 793
+S +K+ L + A PPLW + + V DVNDN PV
Sbjct: 2577 QS-YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPV 2615
Score = 271 bits (664), Expect = 3e-71
Identities = 254/874 (29%), Positives = 394/874 (45%), Gaps = 82/874 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPV---IAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
F + Y+V + E + + PV I + ATD D+GA ++ Y+ F+IDS
Sbjct: 132 FHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSAR 189
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQES 265
G V++++ LDYE ++Y+L + A D +T L I I DV D P F + +
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTN 249
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E+ P G ++ + A D D+G + YT+ GN + +D SG + +G LD
Sbjct: 250 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV--SVAGNTNSIFALDYISGVLTLNGLLD 307
Query: 326 RET---QAKYQLLVTATDGGD--PPRSATATXXXXXXXXXXXXXX--FMPGQYEVELAED 378
RE + L V T+ D P AT T F +Y V + E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 379 EPPGTPV-VTLTATDADEDNRLHYEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFK 432
G + + + D DE +E+ GN F I TS G+ I VA PLD++
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 427
Query: 433 QERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVV 491
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 428 TVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 487
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 488 LATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTI 538
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 539 IARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP 596
Query: 612 LNGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQ 667
N +I Y + F I GVI ++ LD E ++ L +A+D G PP
Sbjct: 597 PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL 656
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVH 723
+STV V I++ D ND+PP F + EN G T+ + A D D G +++
Sbjct: 657 NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII- 715
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR---- 779
YS++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 716 YSLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIA 767
Query: 780 -VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNN 836
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 768 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN- 826
Query: 837 ANLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLIT 888
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 827 -KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV---- 881
Query: 889 EEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 882 ---FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 910
Score = 267 bits (655), Expect = 3e-70
Identities = 252/881 (28%), Positives = 393/881 (44%), Gaps = 76/881 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVRE-GASS----GTTVLTLKATDQDIGKNAEVEYTIELV 65
I V D ND++P F Q Y + E GA+ GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ-- 177
Query: 66 TADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASP 125
P F ID G + LD E Y + V ATDQ
Sbjct: 178 ------PPS-------------QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK- 217
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ LS+ A + + I D D P F Y+ ++ E + I A D D G
Sbjct: 218 -TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP--PGTTVRIITAIDQDKGRPR 274
Query: 186 AIRYAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSR 237
I Y I+ GNT F++D +SG ++L LD E + S+ ++ + D +PS
Sbjct: 275 GIGYTIVSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 334
Query: 238 SN-TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADEGVNAELTYT 295
+ TT I + D+NDNAP F +S + +++E +G+++ + +Q D DEG+N+
Sbjct: 335 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVY 394
Query: 296 MTDKDYTGNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ + + P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV-PDHVGYAKVKI 453
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSI 414
F Y + L E+ GT V+T+ ATD D + RFS+
Sbjct: 454 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSL 513
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPY 474
G LI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y
Sbjct: 514 DKDTG--LIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
++ E+ P T ++ + ATD D N QITYS+ +S A + + G I+
Sbjct: 572 VGALRENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVIS 627
Query: 535 TNKLLDRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
++ LD E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E
Sbjct: 628 VSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVE 687
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESV 650
+ + G +V + ATD D R + + EGS F I+ SG I T LDRE+
Sbjct: 688 NIMAGATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETK 744
Query: 651 ATHDLKAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
+ + L A+DGG T I V+I + DIND+ P ++ + E +P + +
Sbjct: 745 SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTT 804
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------R 760
+ A DPD G N + YSI+ + +SL + G + T LD E+P R
Sbjct: 805 VVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMR 859
Query: 761 KKYELVIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVP 817
K V PPL + V + + D+NDN P ++ + + P G +V
Sbjct: 860 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVV 918
Query: 818 AYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
A D D + + YR+ G L+N ++G + + +L+
Sbjct: 919 AIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 959
Score = 179 bits (436), Expect = 1e-43
Identities = 166/569 (29%), Positives = 256/569 (44%), Gaps = 61/569 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEE----ASRFFAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + + D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVS---DHQGVITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAE-----DEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLI 423
+ E + P GTP+ + ATD D GG+ F SQ + RG++
Sbjct: 140 RIPEVGATGNTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIV 192
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFE 480
TV + LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E
Sbjct: 193 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+P GTTV +++A D D G I Y++ S N + F ++ +G +T N LLD
Sbjct: 253 HSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNT-----NSIFALDYISGVLTLNGLLD 307
Query: 541 RET---MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMED 593
RE G++LTV D PS + TT I V+D+NDN P F Y+ I E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 594 ALVGTSVSQ-VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALD 646
A VG ++ + D D GLN +E+ F+I P S IR LD
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 425
Query: 647 RESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E+V +D A + P V I + + ND+ P+F + EN +GT++
Sbjct: 426 YETVDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 484
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
+ A D D G V Y DD + FSL+ D ++ + LDYE ++ +
Sbjct: 485 LTVLATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTI 538
Query: 767 IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
I RV I V DVNDN P +
Sbjct: 539 IARDGGGEETTGRVRINVLDVNDNVPTFQ 567
Score = 172 bits (418), Expect = 2e-41
Identities = 143/518 (27%), Positives = 233/518 (44%), Gaps = 30/518 (5%)
Query: 375 LAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQE 434
++ED P G+ V L A D D D L + ++G F++ G ++ + QPLD + +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDP-LVFGVSGEEASRFFAVEPDTG--VVWLRQPLDRETK 98
Query: 435 RRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFE-----DAPIGTTVL 489
+ + S +D G T V I + D N+ AP F N PY+ + E + P+GT +
Sbjct: 99 SEFTVEFSVSDHQGVI-TRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIF 157
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
+V+ATD D+G + YS Q F I+ G +T + LD ET Y L
Sbjct: 158 IVNATDPDLGAGGSVLYSFQPP---------SQFFAIDSARGIVTVIRELDYETTQAYQL 208
Query: 550 TVTARD-GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDA 608
TV A D LS ++ I + DV D +P+F Y+ NI E + GT+V + A D
Sbjct: 209 TVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 268
Query: 609 DVGLNGRIHYEL-DPKDREEGSFVIDPASGVIRTNKALDRES-VATH----DLKAVAIDG 662
D G I Y + F +D SGV+ N LDRE+ + +H +K ++
Sbjct: 269 DKGRPRGIGYTIVSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELND 328
Query: 663 GTPPQSSTVIV--HIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDEGPN 719
P +TV +I + DIND+ P F S + I+E + +G + I+ D DEG N
Sbjct: 329 DRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLN 388
Query: 720 AVVHYSIKGGDDSNSFSLETR-QGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWND 777
++ + G + + T QG + + LDYE+ R ++L + P
Sbjct: 389 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGY 448
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA 837
+V+I + + NDN P+ + Y++ V A D D + ++
Sbjct: 449 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP 508
Query: 838 NLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNE 875
+ L++ TG + L +L+ + + T+ + DG E
Sbjct: 509 DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE 546
Score = 124 bits (298), Expect = 6e-27
Identities = 120/406 (29%), Positives = 182/406 (44%), Gaps = 45/406 (11%)
Query: 464 NYAPVFENAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHD 521
N P F N + + ED P+G++V + A D D N + + +S E EA
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGE---EA----S 75
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG-GVPSLSDTTDVEISVVDVNDNEPV 580
+ F + P TG + + LDRET S + + + D GV T V I V DVNDN P
Sbjct: 76 RFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI----TRKVNIQVGDVNDNAPT 131
Query: 581 FKQQLYTANIME-----DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPA 635
F Q Y+ I E + VGT + V ATD D+G G + Y P + F ID A
Sbjct: 132 FHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ---FFAIDSA 188
Query: 636 SGVIRTNKALDRESVATHDLKAVAID-GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
G++ + LD E+ + L A D T P S+ + I I D+ D P+F + +
Sbjct: 189 RGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYST 248
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSI--KGGDDSNSFSLETRQGSDKAELVTMV 752
I E+SP GTT+ I A D D+G + Y+I G+ ++ F+L+ G L
Sbjct: 249 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSIFALDYISG----VLTLNG 304
Query: 753 DLDYESPRKKYELVIRAASPPLWND---------VRVEILVTDVNDNAPVM--KDFQIIF 801
LD E+P + ++ L +D ILV D+NDNAP ++ +
Sbjct: 305 LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAI 364
Query: 802 NNYKDC-FPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETT 846
F + F +V D + + L GNN++ +++ T+
Sbjct: 365 TELAQVGFALPLFIQVVDKDEGLNSMFEV-YLVGNNSHHFIISPTS 409
Score = 89.4 bits (212), Expect = 2e-16
Identities = 82/304 (26%), Positives = 131/304 (43%), Gaps = 35/304 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEA--SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
+ V+D ND+ PVF +RE + V + ATD+D G N V Y+ L TA
Sbjct: 2604 VEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF-LKTAG 2662
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ E F ID SG + T LDRE A Y++++ A+D PV
Sbjct: 2663 NRDWE---------------FFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY 2707
Query: 129 RLSSTATIHVNIIDDNDNY---PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ + IDDN+ P Y + + S V A DAD G N+
Sbjct: 2708 ETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNA 2767
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQD--------GGSPSR 237
+ Y I GN + F + G + +++ LD E+ + +++A G SP+
Sbjct: 2768 IVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTL 2826
Query: 238 SNTTQLLIN-----IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAEL 292
L + + D+ND PRF + + V+ + +G +++V A DAD G N+ +
Sbjct: 2827 DLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLV 2886
Query: 293 TYTM 296
Y++
Sbjct: 2887 FYSI 2890
>AL731541-6|CAI40841.1| 3359|Homo sapiens cadherin-like 23 protein.
Length = 3359
Score = 355 bits (873), Expect = 1e-96
Identities = 274/879 (31%), Positives = 425/879 (48%), Gaps = 59/879 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+N+LD ND+ P F+ + A V EG +G ++ + A D D G N V Y + V +
Sbjct: 883 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP-VGMPRM 941
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F I+ SG ++T LDRE++A Y + V A+D +P
Sbjct: 942 D------------------FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK--- 980
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SST+T+ ++++D ND P F Y VSV ED+ + + TD DVG N+ + Y
Sbjct: 981 SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR--VVWLNCTDNDVGLNAELSYF 1038
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR--SNTTQLLINIR 248
I GGN +FS+ V V LD E +Y L++ A D G + + T + + +
Sbjct: 1039 ITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL 1098
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F S ++ SV E++P G+SI++++A DADEG + Y + ++ N +
Sbjct: 1099 DVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIH 1158
Query: 309 ITIDPRSGWVYTSGQ-LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++ +G + + LDRE + + L+V A + P ++ F
Sbjct: 1159 VS----NGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT 1214
Query: 368 PGQY-EVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
QY + L E GT V+ + ATD D + ++Y I G G+F I GLI
Sbjct: 1215 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEI--DESTGLII 1271
Query: 425 VAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDAN--NYAPVFENAPYTASVFEDA 482
LD++ + Y++ VSATD + + IT N + A F NA Y A++ E+
Sbjct: 1272 TVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENL 1331
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
+GT ++ V A D +N QITY ++ S +A A F I+ TG IT L+DRE
Sbjct: 1332 ALGTEIVRVQAYSID-NLN-QITYRFNAYTSTQAKA----LFKIDAITGVITVQGLVDRE 1385
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA-NIMEDALVGTSVS 601
Y LTV A DGG P + T V I+V+D NDN P F +A +I ED VG V+
Sbjct: 1386 KGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVA 1444
Query: 602 QVGATDADVGLNGRIHYELDPKDREEGSFVI---DPASGVIRTNKALDRESVATHDLKAV 658
V A D D G NG++ + L G+F I + + G + + LDRE + + L+ V
Sbjct: 1445 TVKAWDPDAGSNGQVVFSL-ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVV 1503
Query: 659 AIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC-LTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP+ I+ + I DIND+PPV ES ++EN GT + ++RA D D G
Sbjct: 1504 ASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIG 1563
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
N+V+ Y I G+ +F ++ R + A D + +S V +P L
Sbjct: 1564 INSVLSYYITEGNKDMAFRMD-RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSAT 1622
Query: 778 VRVEILVTDVNDNAPVMKD--FQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILS 833
V + + D NDNAP+ + ++++ + D + A D D + Y I++
Sbjct: 1623 THVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEGPNGTVTYAIVA 1681
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPK-LATMEVSVTD 871
GN N ++ G +T + +L+ + T+ V+ TD
Sbjct: 1682 GNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATD 1720
Score = 350 bits (861), Expect = 4e-95
Identities = 274/832 (32%), Positives = 400/832 (48%), Gaps = 85/832 (10%)
Query: 10 QINVLDCNDHSPVFEMQ-QYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
Q+ +LD ND+ PV E Y SV E GT V+ ++ATD+DIG N+ + Y I D
Sbjct: 1519 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1578
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS 127
FR+D SG + TR A DRE+ + Y ++ D+ +P
Sbjct: 1579 M-------------------AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT- 1618
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS+T ++V I+D+NDN P F + Y V +DE + +I I+A D D G N +
Sbjct: 1619 --LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-IQALDLDEGPNGTV 1675
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRS-YRLVIRAQDGG---SPSRSNTTQL 243
YAI+ GN F ID G ++ K LDYE Y L++ A D S ++TT +
Sbjct: 1676 TYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1735
Query: 244 LINIRDVNDNAPRF---YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKD 300
L+N+ D+NDN P F Y F+ V+E P G + A+D D G N ++ Y++ D D
Sbjct: 1736 LVNVNDINDNVPTFPRDYEGPFE--VTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGD 1792
Query: 301 YTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
G I P G V +LDRET A Y L + A D G PP S+T
Sbjct: 1793 PLGE----FVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLD 1848
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITS 416
+ + ++E+ P + V + A+DAD + RL + IT GN F I +
Sbjct: 1849 INDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINA 1908
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG-----GRSDTAMVQINITDANNYAPVFEN 471
G ++TV +PLD ++ Y LT+S D+ R D ++ I ++D N+ P+F
Sbjct: 1909 TTG--IVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1966
Query: 472 APYTASVFEDAPIGTTVLVVS----ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ Y A V E++P GT + V++ A D+D I A +TY L S F IN
Sbjct: 1967 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG--------LFDIN 2018
Query: 528 PQTGAITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
TG +T ++DRE S +L + + L+ T + I+++D NDN P F
Sbjct: 2019 SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPAT 2078
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRT-NKA 644
T +++E+ G SV QV ATD D GLNG + Y ++ ++ F+I +GVIR N
Sbjct: 2079 LTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR--FLIHLVTGVIRVGNAT 2136
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
+DRE ++ L VA D GT P S T IV I I+DINDS P F + T + E++ GT
Sbjct: 2137 IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGT 2196
Query: 705 TIGEIRAHDPDEGPNAVVH-YSIKGGDDS--------NSFSLETRQGS------DKAELV 749
I I A D D P H I DD+ ++F++ GS ELV
Sbjct: 2197 VIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELV 2256
Query: 750 TMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIF 801
++ +L R+ S P + ++ + V DVNDN P K F I +
Sbjct: 2257 ATYEVTLSVIDNASDLPERSVSVP---NAKLTVNVLDVNDNTPQFKPFGITY 2305
Score = 347 bits (852), Expect = 5e-94
Identities = 267/859 (31%), Positives = 406/859 (47%), Gaps = 51/859 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND+ P ++ Y ++ E + V T+ A D D+G+N + Y+I+
Sbjct: 771 ITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ------- 823
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P + ++ + R A L R+ ++V TD P +
Sbjct: 824 -PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK------IVVSVTDCGRPPL-KA 875
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+AT+ VN++D NDN P F + V E I + I ++ A D D G N + Y
Sbjct: 876 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVS--IYQVVAIDLDEGLNGLVSYR 933
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ G +M F I+S SG V LD E++ Y+L + A D G+P++S+T+ L I++ DV
Sbjct: 934 MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDV 993
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
ND P F+ +++ SVSE+VP + +V + D D G+NAEL+Y +T GNVD +
Sbjct: 994 NDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG----GNVDGKFS 1049
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR--SATATXXXXXXXXXXXXXXFMP 368
+ R V T LDRET A Y L++ A D G + + TAT F+
Sbjct: 1050 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1109
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRGLITVA 426
YE + ED P G ++ L ATDADE R+ Y I GN F I NG L+
Sbjct: 1110 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGL-LMRGP 1168
Query: 427 QPLDFKQERRYVLTVSA--TDSGGRSDTAMVQINITDANNYAPVFENAPYT-ASVFEDAP 483
+PLD ++ +VL V A D G + V + + D N+ APVF Y+ + E A
Sbjct: 1169 RPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1228
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
IGT+V+VV ATD D G + Y + S + +F I+ TG I T LD ET
Sbjct: 1229 IGTSVIVVQATDRDSGDGGLVNYRILSGA--------EGKFEIDESTGLIITVNYLDYET 1280
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y++ V+A D P V I++++ D F Y A I+E+ +GT + +V
Sbjct: 1281 KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRV 1340
Query: 604 GATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAID 661
A D LN +I Y + + + F ID +GVI +DRE + L VA D
Sbjct: 1341 QAYSID-NLN-QITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADD 1398
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFE-SDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
GG P STV V+I + D ND+ P F+ + I E+ P+G + ++A DPD G N
Sbjct: 1399 GG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNG 1457
Query: 721 VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V +S+ G+ + +F + T S E+ LD E Y L + A+ +PP D
Sbjct: 1458 QVVFSLASGNIAGAFEIVTTNDS-IGEVFVARPLDREE-LDHYILQVVASDRGTPPRKKD 1515
Query: 778 VRVEILVTDVNDNAPVMKD---FQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSG 834
+++ + D+NDN PV++ + + N R D + L Y I G
Sbjct: 1516 HILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEG 1575
Query: 835 NNANLILLNETTGSMTLSP 853
N ++ +G + P
Sbjct: 1576 NKDMAFRMDRISGEIATRP 1594
Score = 338 bits (831), Expect = 2e-91
Identities = 266/889 (29%), Positives = 409/889 (46%), Gaps = 75/889 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 452 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 505
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 506 ---DD------------PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 546
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 547 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 602
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 603 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 662
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 663 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSL 718
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DG G ++ AT
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTG 836
Query: 420 R-----GLITVAQPLDFKQERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFE 470
+ ++ P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 837 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 896
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 897 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSS 949
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 950 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1009
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESV 650
ED V + TD DVGLN + Y + +G F + V+RT LDRE+
Sbjct: 1010 SEDVPREFRVVWLNCTDNDVGLNAELSYFI-TGGNVDGKFSVGYRDAVVRTVVGLDRETT 1068
Query: 651 ATHDLKAVAIDGGT--PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A + L AID G + T V + + D+ND+ P+F + E+ P G +I +
Sbjct: 1069 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1128
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
++A D DEG V Y I G+ N+F + G + LD E + L++
Sbjct: 1129 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG---LLMRGPRPLDRER-NSSHVLIVE 1184
Query: 769 AAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVT 824
A + P+ + VRV + V D+ND APV Q ++ +G V A D D
Sbjct: 1185 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1244
Query: 825 D--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D + YRILSG ++E+TG + L+ M VS TD
Sbjct: 1245 DGGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATD 1292
Score = 336 bits (825), Expect = 9e-91
Identities = 274/889 (30%), Positives = 419/889 (47%), Gaps = 83/889 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASS-GTTVLTLKATDQDIGKNAEVEYTIELVT 66
H + ++D ND++P+F+ YE + EG + T+++T++A D D G N V Y I V
Sbjct: 1624 HVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI--VA 1681
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDRE-KVARYTVLVKATDQASP 125
+ +N FRID G + LD E RYT++V ATDQ
Sbjct: 1682 GNIVN-----------------TFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPI 1724
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+S RL+ST T+ VN+ D NDN P F + Y E P + A D D G N
Sbjct: 1725 LSHRLTSTTTVLVNVNDINDNVPTF-PRDYE-GPFEVTEGQPGPRVWTFLAHDRDSGPNG 1782
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQL 243
+ Y+I+ G+ +F I + G + + K LD E + Y L I A+D G P S+T +
Sbjct: 1783 QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLV 1842
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D+NDN P ++SEN P+ + V A DAD G NA LT+ +T G
Sbjct: 1843 GIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT----AG 1898
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
N + I+ +G V + LDRE +Y+L ++ D + PR A
Sbjct: 1899 NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDEN 1958
Query: 364 X---XFMPGQYEVELAEDEPPGTPVVTLT----ATDADED--NRLHYEITGGNTRGRFSI 414
F Y+ E+ E+ P GTP+ L A DAD+D + Y++ G + G F I
Sbjct: 1959 DNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS-GLFDI 2017
Query: 415 TSQNGRGLITVAQPLDFKQER----RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE 470
S G++TV + +E L + A D G + TA + I I D N+ P F
Sbjct: 2018 NSST--GVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2075
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
A T + E+ P G +VL V+ATD D G+N ++ Y + EA A +F+I+ T
Sbjct: 2076 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGA--QDRFLIHLVT 2127
Query: 531 GAITT-NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
G I N +DRE Y LTV A D G LS T V I + D+ND+ P F + T +
Sbjct: 2128 GVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVS 2187
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYEL------DPKDR----EEGSFVIDPASGVI 639
++E A GT ++ + A D D LN ++ Y + D DR +E +F ++ +G +
Sbjct: 2188 VLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSV 2245
Query: 640 RTNKALDRESVATHDLKAVAIDGGTP-PQSSTVIVHIKIE----DINDSPPVFESDCLTF 694
++RE VAT+++ ID + P+ S + + K+ D+ND+ P F+ +T+
Sbjct: 2246 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2305
Query: 695 Y---ISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
Y I E + GTT+ + A DPD+G N +V Y++ LE S +++
Sbjct: 2306 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE---DSSAGKVIAN 2362
Query: 752 VDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
+DYE +RA+ SPP ++ V + + D+NDN P+ ++D
Sbjct: 2363 RTVDYEEVH-WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFED-V 2420
Query: 809 PVGP-FGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
PVG V A DAD + G+ + +N TTG + + L+
Sbjct: 2421 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2469
Score = 330 bits (811), Expect = 4e-89
Identities = 278/882 (31%), Positives = 411/882 (46%), Gaps = 62/882 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ P+F YEASV E G ++L LKATD D G+ V Y I L
Sbjct: 1095 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI-------L 1147
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRAS-LDREKVARYTVLVKATDQASPVSDR 129
+ FRI +G L+ LDRE+ + + ++V+A +
Sbjct: 1148 HGNHGNN------------FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL---GP 1192
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYT-VSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ S+ + V + D ND P F+++ Y+ + + E + + ++ ++ATD D G +
Sbjct: 1193 MRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIV--VQATDRDSGDGGLVN 1250
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y I+ G + +F ID +G + V LDYE SY + + A D P + I +
Sbjct: 1251 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLL 1309
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
+ D A +F + ++ ++ EN+ +G IVRVQAY D +N ++TY T L
Sbjct: 1310 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN-LN-QITYRFNAYTSTQAKAL- 1366
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
ID +G + G +DRE Y L V A DGG S
Sbjct: 1367 FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFT 1426
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR-GLITV 425
V + ED P G V T+ A D D + ++ + + GN G F I + N G + V
Sbjct: 1427 SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFV 1486
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENA-PYTASVFEDA 482
A+PLD ++ Y+L V A+D G R ++Q+ I D N+ PV E+ Y SV E+
Sbjct: 1487 ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1546
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL-DR 541
GT V+ V ATD D+GIN+ ++Y ++ + D F ++ +G I T DR
Sbjct: 1547 GGGTAVVQVRATDRDIGINSVLSYYITE-------GNKDMAFRMDRISGEIATRPAPPDR 1599
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA-LVGTSV 600
E S Y L T D G P+LS TT V +++VD NDN P+F+Q Y + E + TS+
Sbjct: 1600 ERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSL 1659
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE-SVATHDLKAVA 659
+ A D D G NG + Y + +F ID GVI K LD E S + L A
Sbjct: 1660 ITIQALDLDEGPNGTVTYAI-VAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTA 1718
Query: 660 IDGG---TPPQSSTVIVHIKIEDINDSPPVFESDCL-TFYISENSPIGTTIGEIRAHDPD 715
D + +ST V + + DIND+ P F D F ++E P G + AHD D
Sbjct: 1719 TDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRD 1777
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---P 772
GPN V YSI GD F + +G + V+LD E+ Y L I A P
Sbjct: 1778 SGPNGQVEYSIMDGDPLGEFVISPVEGVLRVR--KDVELDRETIAF-YNLTICARDRGMP 1834
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDAD--VTDKLQY 829
PL + + V I V D+NDN PV+ + + ++ PV F V A DAD +L +
Sbjct: 1835 PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENS-PVSSFVAHVLASDADSGCNARLTF 1893
Query: 830 RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
I +GN +N TTG +T++ L+ + +SV D
Sbjct: 1894 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1935
Score = 327 bits (803), Expect = 4e-88
Identities = 273/868 (31%), Positives = 416/868 (47%), Gaps = 76/868 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +L+ D + F YEA++ E + GT ++ ++A Y+I D L
Sbjct: 1306 ITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQA------------YSI-----DNL 1348
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N + + +F+ID +G + + +DREK YT+ V A D P ++
Sbjct: 1349 N-QITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGP---KV 1403
Query: 131 SSTATIHVNIIDDNDNYPQFS-EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
ST +++ ++D+NDN P+F VS+ ED V +A +KA D D G+N + +
Sbjct: 1404 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQR--VATVKAWDPDAGSNGQVVF 1461
Query: 190 AIIGGNTQMQFSI----DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
++ GN F I DS+ G+V + + LD E++ Y L + A D G+P R L +
Sbjct: 1462 SLASGNIAGAFEIVTTNDSI-GEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQV 1520
Query: 246 NIRDVNDNAPRFYTSL-FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
I D+NDN P + + SV+ENV G ++V+V+A D D G+N+ L+Y +T+ GN
Sbjct: 1521 TILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE----GN 1576
Query: 305 VDLPITIDPRSGWVYTS-GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
D+ +D SG + T DRE Q+ Y L+ T D G P SAT
Sbjct: 1577 KDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNA 1636
Query: 364 XXFMPGQYEVELAED-EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGR 420
F YEV L E + T ++T+ A D DE + + Y I GN F I
Sbjct: 1637 PMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH--M 1694
Query: 421 GLITVAQPLDFK-QERRYVLTVSATD-----SGGRSDTAMVQINITDANNYAPVFEN--- 471
G+IT A+ LD++ RY L V+ATD S + T V +N+ D N+ P F
Sbjct: 1695 GVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYE 1754
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
P+ V E P G V A D D G N Q+ YS+ + + + +FVI+P G
Sbjct: 1755 GPF--EVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSI---MDGDPLG----EFVISPVEG 1804
Query: 532 AITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
+ K LDRET++ Y LT+ ARD G+P LS T V I V+D+NDN+PV
Sbjct: 1805 VLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNIT 1864
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES 649
I E++ V + V+ V A+DAD G N R+ + + +RE +F I+ +G++ N+ LDRE
Sbjct: 1865 ISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRER-AFFINATTGIVTVNRPLDRER 1923
Query: 650 VATHDLKAVAIDGGTPPQSSTV---IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
+ + L D P+ + ++ I + D ND+ P+F + ENSP GT +
Sbjct: 1924 IPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPL 1983
Query: 707 ----GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKK 762
G I A D D+ AVV Y + G S F + + G ++D + SP
Sbjct: 1984 TVLNGPILALDADQDIYAVVTYQLLGAQ-SGLFDINSSTGVVTVRSGVIIDREAFSP-PI 2041
Query: 763 YELVIRAASPPLWNDV-RVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
EL++ A L N + I + D NDN P + + ++C P +V A D
Sbjct: 2042 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2101
Query: 822 D--VTDKLQYRILSGNNANLILLNETTG 847
D + +L YRI +G + L++ TG
Sbjct: 2102 DSGLNGELVYRIEAGAQ-DRFLIHLVTG 2128
Score = 318 bits (780), Expect = 2e-85
Identities = 267/872 (30%), Positives = 418/872 (47%), Gaps = 77/872 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEA-SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+ V D ND +PVF QQY +RE A GT+V+ ++ATD+D G V Y I
Sbjct: 1201 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI------- 1253
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ F ID +G ++T LD E Y + V ATDQA P +
Sbjct: 1254 -------------LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG 1300
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S +++ ++++ D QFS +Y ++ E++++ I +++A D R+
Sbjct: 1301 FCS---VYITLLNELDEAVQFSNASYEAAILENLALGTE--IVRVQAYSIDNLNQITYRF 1355
Query: 190 -AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
A + F ID+++G +++ +D E+ Y L + A DGG P +T ++ I +
Sbjct: 1356 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVL 1414
Query: 249 DVNDNAPRF-YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D NDN+PRF +TS S+ E+ P+G + V+A+D D G N ++ +++ + G ++
Sbjct: 1415 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1474
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF- 366
+T + G V+ + LDRE Y L V A+D G PPR
Sbjct: 1475 -VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIE 1533
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLIT 424
P Y V + E+ GT VV + ATD D ++ L Y IT GN F + +G + T
Sbjct: 1534 SPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE-IAT 1592
Query: 425 VAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
P D +++ Y L + D G S T V + I D N+ AP+F+ P+ + ++
Sbjct: 1593 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ-PHYEVLLDEG 1651
Query: 483 P--IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
P + T+++ + A D D G N +TY++ ++ V F I+ G IT K LD
Sbjct: 1652 PDTLNTSLITIQALDLDEGPNGTVTYAI---VAGNIV----NTFRIDRHMGVITAAKELD 1704
Query: 541 RETMSG-YLLTVTARDGGVPSLS----DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
E G Y L VTA D P LS TT V ++V D+NDN P F + + +
Sbjct: 1705 YEISHGRYTLIVTATDQ-CPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQ 1763
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNK--ALDRESVATH 653
G V A D D G NG++ Y + D G FVI P GV+R K LDRE++A +
Sbjct: 1764 PGPRVWTFLAHDRDSGPNGQVEYSIMDGD-PLGEFVISPVEGVLRVRKDVELDRETIAFY 1822
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
+L A D G PP SST++V I++ DIND+ PV + + ISENSP+ + + + A D
Sbjct: 1823 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1882
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM-VDLDYESPRKKYELVIRAASP 772
D G NA + ++I G+ +F + G +VT+ LD E +Y+L I
Sbjct: 1883 ADSGCNARLTFNITAGNRERAFFINATTG-----IVTVNRPLDRER-IPEYKLTISVKDN 1936
Query: 773 PLWNDVR------VEILVTDVNDNAPVM--KDFQI-IFNNYKDCFPV----GPFGRVPAY 819
P + + I ++D NDN P+ +Q + N P+ GP + A
Sbjct: 1937 PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA- 1995
Query: 820 DADVTDKLQYRILSGNNANLILLNETTGSMTL 851
D D+ + Y++L G + L +N +TG +T+
Sbjct: 1996 DQDIYAVVTYQLL-GAQSGLFDINSSTGVVTV 2026
Score = 305 bits (750), Expect = 1e-81
Identities = 256/901 (28%), Positives = 414/901 (45%), Gaps = 58/901 (6%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 553 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 610
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTV--LVKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 611 FG-------------SYFDISLYEG-YGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-- 654
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 655 -PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 711
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 712 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 771
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM--TDKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 772 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 831
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 832 N-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 890
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +
Sbjct: 891 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS- 949
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 950 -GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1008
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V ED P V+ ++ TD+DVG+NA+++Y ++ + D +F + + + T
Sbjct: 1009 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITG-------GNVDGKFSVGYRDAVVRTVV 1061
Query: 538 LLDRETMSGYLLTVTARDGGVPSL--SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
LDRET + Y+L + A D G + T V ++V+DVNDN P+F Q Y A++ ED
Sbjct: 1062 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIP 1121
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVI-RTNKALDRESVATHD 654
G S+ Q+ ATDAD G GR+ Y + +F I ++G++ R + LDRE ++H
Sbjct: 1122 EGHSILQLKATDADEGEFGRVWYRI-LHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1180
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-ESDCLTFYISENSPIGTTIGEIRAHD 713
L A + P S+V V + +EDIND PVF + + E + IGT++ ++A D
Sbjct: 1181 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATD 1240
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPP 773
D G +V+Y I G + F ++ G ++T+ LDYE+ V P
Sbjct: 1241 RDSGDGGLVNYRILSGAE-GKFEIDESTGL----IITVNYLDYETKTSYMMNVSATDQAP 1295
Query: 774 LWNDVRVEILVTDVN--DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRI 831
+N + +T +N D A + ++ RV AY D +++ YR
Sbjct: 1296 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRF 1355
Query: 832 ---LSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLIT 888
S L ++ TG +T+ ++ T+ V DG ++ + +++ + ++
Sbjct: 1356 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLD 1415
Query: 889 E 889
E
Sbjct: 1416 E 1416
Score = 295 bits (725), Expect = 1e-78
Identities = 238/779 (30%), Positives = 370/779 (47%), Gaps = 71/779 (9%)
Query: 15 DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPED 74
D ND P F SV E A GT + + A D D+ N ++EY I + A +D
Sbjct: 2171 DINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAK----DD 2224
Query: 75 AXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSST- 133
+D F ++ +G+++ ++ ++RE VA Y V + D AS + +R S
Sbjct: 2225 TDRLVPNQ----EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2280
Query: 134 -ATIHVNIIDDNDNYPQFSEKTYTVSVDEDIS-VTDNPVIAKIKATDADVGANSAIRYAI 191
A + VN++D NDN PQF T ++ + T + + A D D G N + Y +
Sbjct: 2281 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 2340
Query: 192 IG----GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ G Q++ DS +G V +T+DYE+V +RA D GSP R+ + + I
Sbjct: 2341 LDLVPPGYVQLE---DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 2397
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D+NDN P F +QE+V E+VP+G I+ V A DAD G A + Y++ G+ +
Sbjct: 2398 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL------GDGES 2451
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG-GDPP---RSATATXXXXXXXXXXXX 363
I+P +G +Y LDRE + Y L A D GD R +
Sbjct: 2452 KFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCR 2511
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F Q+ + E+EP GT V+T+ ATD DE + L Y + G F + + G
Sbjct: 2512 PQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDS--G 2568
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAP--YTAS 477
L+T +PL + ++ LTV ATD G T M+ + + D N+ PVF P
Sbjct: 2569 LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILH 2626
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ P+ + V V ATD D G+N + YS N + F+I+P +G I T +
Sbjct: 2627 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGN----RDWEFFIIDPISGLIQTAQ 2682
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVF------KQQLYTANI 590
LDRE+ + Y L + A D G P +T +++++ D++DNEP+F Q +
Sbjct: 2683 RLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2742
Query: 591 MEDALVGTSVSQV-GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALD--R 647
E + GT V V GA DAD G N ++Y + EE +F + P G + + LD R
Sbjct: 2743 PEHSPRGTLVGNVTGAVDADEGPNAIVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDRER 2800
Query: 648 ESVATHDLKAVAIDGGTPPQ--SSTV---------IVHIKIEDINDSPPVFESDCLTFYI 696
E++ + +KA + TPP+ S T+ V + +EDIND PP F T +
Sbjct: 2801 EAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2860
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD 755
+ ++ +G+ + ++ A D D G N++V YSI + F D ++ TM +D
Sbjct: 2861 ATDAKVGSELIQVLALDADIGNNSLVFYSILA---IHYFRALANDSEDVGQVFTMGSMD 2916
Score = 287 bits (703), Expect = 5e-76
Identities = 247/820 (30%), Positives = 373/820 (45%), Gaps = 85/820 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ PV ++ E + + V + A+D D G NA + + I TA
Sbjct: 1844 IRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAG-- 1898
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N E A F I+ +G + LDRE++ Y + + D +P + R+
Sbjct: 1899 NRERA--------------FFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPRI 1942
Query: 131 SSTA--TIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIA---KIKATDADVGANS 185
+ + + + D+NDN+P F++ TY V E+ S P+ I A DAD +
Sbjct: 1943 ARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMEN-SPAGTPLTVLNGPILALDADQDIYA 2001
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRS--YRLVIRAQDGGSPSRSNTT 241
+ Y ++G + + F I+S +G V++ +D E L++ A+D G ++T
Sbjct: 2002 VVTYQLLGAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTA 2058
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
LLI I D NDN P F + + EN P G+S+++V A D D G+N EL Y +
Sbjct: 2059 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ 2118
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+ +T R G + +DRE Q Y+L V ATD G P S TA
Sbjct: 2119 DRFLIHLVTGVIRVG----NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIND 2174
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITG-----------GNTRG 410
F+ V + E PGT + +TA D D + +L Y I G N
Sbjct: 2175 SRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQED 2234
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG----RS---DTAMVQINITDAN 463
F++ G + V P++ + Y +T+S D+ RS A + +N+ D N
Sbjct: 2235 AFAVNINTGS--VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVN 2292
Query: 464 NYAPVFEN---APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH 520
+ P F+ Y + E A GTT++ V+A D D G+N +TY+L + V
Sbjct: 2293 DNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2352
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
D G + N+ +D E + TV A D G P + V + +VD+NDN P+
Sbjct: 2353 DSS------AGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPI 2406
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR 640
F Q Y + ED VGT + V ATDAD G I Y L E F I+P +G I
Sbjct: 2407 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG---ESKFAINPTTGDIY 2463
Query: 641 TNKALDRESVATHDLKAVAIDG----GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYI 696
+LDRE + L A+A D + + ++V V I++ D+ND P F + +
Sbjct: 2464 VLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSV 2523
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDY 756
EN P GT++ + A D DEGPN + YS++G +F ++ G LVT
Sbjct: 2524 YENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEAFHVDMDSG-----LVT-TQRPL 2576
Query: 757 ESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPV 793
+S +K+ L + A PPLW + + V DVNDN PV
Sbjct: 2577 QS-YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPV 2615
Score = 271 bits (664), Expect = 3e-71
Identities = 254/874 (29%), Positives = 394/874 (45%), Gaps = 82/874 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPV---IAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
F + Y+V + E + + PV I + ATD D+GA ++ Y+ F+IDS
Sbjct: 132 FHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSAR 189
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQES 265
G V++++ LDYE ++Y+L + A D +T L I I DV D P F + +
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTN 249
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E+ P G ++ + A D D+G + YT+ GN + +D SG + +G LD
Sbjct: 250 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV--SVAGNTNSIFALDYISGVLTLNGLLD 307
Query: 326 RET---QAKYQLLVTATDGGD--PPRSATATXXXXXXXXXXXXXX--FMPGQYEVELAED 378
RE + L V T+ D P AT T F +Y V + E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 379 EPPGTPV-VTLTATDADEDNRLHYEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFK 432
G + + + D DE +E+ GN F I TS G+ I VA PLD++
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 427
Query: 433 QERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVV 491
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 428 TVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 487
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 488 LATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTI 538
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 539 IARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP 596
Query: 612 LNGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQ 667
N +I Y + F I GVI ++ LD E ++ L +A+D G PP
Sbjct: 597 PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL 656
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVH 723
+STV V I++ D ND+PP F + EN G T+ + A D D G +++
Sbjct: 657 NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII- 715
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR---- 779
YS++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 716 YSLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIA 767
Query: 780 -VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNN 836
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 768 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN- 826
Query: 837 ANLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLIT 888
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 827 -KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV---- 881
Query: 889 EEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 882 ---FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 910
Score = 267 bits (655), Expect = 3e-70
Identities = 252/881 (28%), Positives = 393/881 (44%), Gaps = 76/881 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVRE-GASS----GTTVLTLKATDQDIGKNAEVEYTIELV 65
I V D ND++P F Q Y + E GA+ GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ-- 177
Query: 66 TADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASP 125
P F ID G + LD E Y + V ATDQ
Sbjct: 178 ------PPS-------------QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK- 217
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ LS+ A + + I D D P F Y+ ++ E + I A D D G
Sbjct: 218 -TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP--PGTTVRIITAIDQDKGRPR 274
Query: 186 AIRYAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSR 237
I Y I+ GNT F++D +SG ++L LD E + S+ ++ + D +PS
Sbjct: 275 GIGYTIVSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 334
Query: 238 SN-TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADEGVNAELTYT 295
+ TT I + D+NDNAP F +S + +++E +G+++ + +Q D DEG+N+
Sbjct: 335 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVY 394
Query: 296 MTDKDYTGNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ + + P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV-PDHVGYAKVKI 453
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSI 414
F Y + L E+ GT V+T+ ATD D + RFS+
Sbjct: 454 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSL 513
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPY 474
G LI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y
Sbjct: 514 DKDTG--LIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
++ E+ P T ++ + ATD D N QITYS+ +S A + + G I+
Sbjct: 572 VGALRENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVIS 627
Query: 535 TNKLLDRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
++ LD E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E
Sbjct: 628 VSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVE 687
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESV 650
+ + G +V + ATD D R + + EGS F I+ SG I T LDRE+
Sbjct: 688 NIMAGATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETK 744
Query: 651 ATHDLKAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
+ + L A+DGG T I V+I + DIND+ P ++ + E +P + +
Sbjct: 745 SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTT 804
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------R 760
+ A DPD G N + YSI+ + +SL + G + T LD E+P R
Sbjct: 805 VVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMR 859
Query: 761 KKYELVIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVP 817
K V PPL + V + + D+NDN P ++ + + P G +V
Sbjct: 860 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVV 918
Query: 818 AYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
A D D + + YR+ G L+N ++G + + +L+
Sbjct: 919 AIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 959
Score = 179 bits (436), Expect = 1e-43
Identities = 166/569 (29%), Positives = 256/569 (44%), Gaps = 61/569 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEE----ASRFFAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + + D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVS---DHQGVITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAE-----DEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLI 423
+ E + P GTP+ + ATD D GG+ F SQ + RG++
Sbjct: 140 RIPEVGATGNTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIV 192
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFE 480
TV + LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E
Sbjct: 193 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+P GTTV +++A D D G I Y++ S N + F ++ +G +T N LLD
Sbjct: 253 HSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNT-----NSIFALDYISGVLTLNGLLD 307
Query: 541 RET---MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMED 593
RE G++LTV D PS + TT I V+D+NDN P F Y+ I E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 594 ALVGTSVSQ-VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALD 646
A VG ++ + D D GLN +E+ F+I P S IR LD
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 425
Query: 647 RESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E+V +D A + P V I + + ND+ P+F + EN +GT++
Sbjct: 426 YETVDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 484
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
+ A D D G V Y DD + FSL+ D ++ + LDYE ++ +
Sbjct: 485 LTVLATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTI 538
Query: 767 IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
I RV I V DVNDN P +
Sbjct: 539 IARDGGGEETTGRVRINVLDVNDNVPTFQ 567
Score = 172 bits (418), Expect = 2e-41
Identities = 143/518 (27%), Positives = 233/518 (44%), Gaps = 30/518 (5%)
Query: 375 LAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQE 434
++ED P G+ V L A D D D L + ++G F++ G ++ + QPLD + +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDP-LVFGVSGEEASRFFAVEPDTG--VVWLRQPLDRETK 98
Query: 435 RRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFE-----DAPIGTTVL 489
+ + S +D G T V I + D N+ AP F N PY+ + E + P+GT +
Sbjct: 99 SEFTVEFSVSDHQGVI-TRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIF 157
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
+V+ATD D+G + YS Q F I+ G +T + LD ET Y L
Sbjct: 158 IVNATDPDLGAGGSVLYSFQPP---------SQFFAIDSARGIVTVIRELDYETTQAYQL 208
Query: 550 TVTARD-GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDA 608
TV A D LS ++ I + DV D +P+F Y+ NI E + GT+V + A D
Sbjct: 209 TVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 268
Query: 609 DVGLNGRIHYEL-DPKDREEGSFVIDPASGVIRTNKALDRES-VATH----DLKAVAIDG 662
D G I Y + F +D SGV+ N LDRE+ + +H +K ++
Sbjct: 269 DKGRPRGIGYTIVSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELND 328
Query: 663 GTPPQSSTVIV--HIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDEGPN 719
P +TV +I + DIND+ P F S + I+E + +G + I+ D DEG N
Sbjct: 329 DRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLN 388
Query: 720 AVVHYSIKGGDDSNSFSLETR-QGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWND 777
++ + G + + T QG + + LDYE+ R ++L + P
Sbjct: 389 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGY 448
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA 837
+V+I + + NDN P+ + Y++ V A D D + ++
Sbjct: 449 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP 508
Query: 838 NLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNE 875
+ L++ TG + L +L+ + + T+ + DG E
Sbjct: 509 DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE 546
Score = 124 bits (298), Expect = 6e-27
Identities = 120/406 (29%), Positives = 182/406 (44%), Gaps = 45/406 (11%)
Query: 464 NYAPVFENAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHD 521
N P F N + + ED P+G++V + A D D N + + +S E EA
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGE---EA----S 75
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG-GVPSLSDTTDVEISVVDVNDNEPV 580
+ F + P TG + + LDRET S + + + D GV T V I V DVNDN P
Sbjct: 76 RFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI----TRKVNIQVGDVNDNAPT 131
Query: 581 FKQQLYTANIME-----DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPA 635
F Q Y+ I E + VGT + V ATD D+G G + Y P + F ID A
Sbjct: 132 FHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ---FFAIDSA 188
Query: 636 SGVIRTNKALDRESVATHDLKAVAID-GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
G++ + LD E+ + L A D T P S+ + I I D+ D P+F + +
Sbjct: 189 RGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYST 248
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSI--KGGDDSNSFSLETRQGSDKAELVTMV 752
I E+SP GTT+ I A D D+G + Y+I G+ ++ F+L+ G L
Sbjct: 249 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSIFALDYISG----VLTLNG 304
Query: 753 DLDYESPRKKYELVIRAASPPLWND---------VRVEILVTDVNDNAPVM--KDFQIIF 801
LD E+P + ++ L +D ILV D+NDNAP ++ +
Sbjct: 305 LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAI 364
Query: 802 NNYKDC-FPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETT 846
F + F +V D + + L GNN++ +++ T+
Sbjct: 365 TELAQVGFALPLFIQVVDKDEGLNSMFEV-YLVGNNSHHFIISPTS 409
Score = 89.4 bits (212), Expect = 2e-16
Identities = 82/304 (26%), Positives = 131/304 (43%), Gaps = 35/304 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEA--SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
+ V+D ND+ PVF +RE + V + ATD+D G N V Y+ L TA
Sbjct: 2604 VEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF-LKTAG 2662
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ E F ID SG + T LDRE A Y++++ A+D PV
Sbjct: 2663 NRDWE---------------FFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY 2707
Query: 129 RLSSTATIHVNIIDDNDNY---PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ + IDDN+ P Y + + S V A DAD G N+
Sbjct: 2708 ETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNA 2767
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQD--------GGSPSR 237
+ Y I GN + F + G + +++ LD E+ + +++A G SP+
Sbjct: 2768 IVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTL 2826
Query: 238 SNTTQLLIN-----IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAEL 292
L + + D+ND PRF + + V+ + +G +++V A DAD G N+ +
Sbjct: 2827 DLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLV 2886
Query: 293 TYTM 296
Y++
Sbjct: 2887 FYSI 2890
>AL359183-3|CAI13426.1| 3359|Homo sapiens cadherin-like 23 protein.
Length = 3359
Score = 355 bits (873), Expect = 1e-96
Identities = 274/879 (31%), Positives = 425/879 (48%), Gaps = 59/879 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+N+LD ND+ P F+ + A V EG +G ++ + A D D G N V Y + V +
Sbjct: 883 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP-VGMPRM 941
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F I+ SG ++T LDRE++A Y + V A+D +P
Sbjct: 942 D------------------FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK--- 980
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SST+T+ ++++D ND P F Y VSV ED+ + + TD DVG N+ + Y
Sbjct: 981 SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR--VVWLNCTDNDVGLNAELSYF 1038
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR--SNTTQLLINIR 248
I GGN +FS+ V V LD E +Y L++ A D G + + T + + +
Sbjct: 1039 ITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL 1098
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F S ++ SV E++P G+SI++++A DADEG + Y + ++ N +
Sbjct: 1099 DVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIH 1158
Query: 309 ITIDPRSGWVYTSGQ-LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++ +G + + LDRE + + L+V A + P ++ F
Sbjct: 1159 VS----NGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT 1214
Query: 368 PGQY-EVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
QY + L E GT V+ + ATD D + ++Y I G G+F I GLI
Sbjct: 1215 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEI--DESTGLII 1271
Query: 425 VAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDAN--NYAPVFENAPYTASVFEDA 482
LD++ + Y++ VSATD + + IT N + A F NA Y A++ E+
Sbjct: 1272 TVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENL 1331
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
+GT ++ V A D +N QITY ++ S +A A F I+ TG IT L+DRE
Sbjct: 1332 ALGTEIVRVQAYSID-NLN-QITYRFNAYTSTQAKA----LFKIDAITGVITVQGLVDRE 1385
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA-NIMEDALVGTSVS 601
Y LTV A DGG P + T V I+V+D NDN P F +A +I ED VG V+
Sbjct: 1386 KGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVA 1444
Query: 602 QVGATDADVGLNGRIHYELDPKDREEGSFVI---DPASGVIRTNKALDRESVATHDLKAV 658
V A D D G NG++ + L G+F I + + G + + LDRE + + L+ V
Sbjct: 1445 TVKAWDPDAGSNGQVVFSL-ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVV 1503
Query: 659 AIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC-LTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP+ I+ + I DIND+PPV ES ++EN GT + ++RA D D G
Sbjct: 1504 ASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIG 1563
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
N+V+ Y I G+ +F ++ R + A D + +S V +P L
Sbjct: 1564 INSVLSYYITEGNKDMAFRMD-RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSAT 1622
Query: 778 VRVEILVTDVNDNAPVMKD--FQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILS 833
V + + D NDNAP+ + ++++ + D + A D D + Y I++
Sbjct: 1623 THVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEGPNGTVTYAIVA 1681
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPK-LATMEVSVTD 871
GN N ++ G +T + +L+ + T+ V+ TD
Sbjct: 1682 GNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATD 1720
Score = 350 bits (861), Expect = 4e-95
Identities = 274/832 (32%), Positives = 400/832 (48%), Gaps = 85/832 (10%)
Query: 10 QINVLDCNDHSPVFEMQ-QYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
Q+ +LD ND+ PV E Y SV E GT V+ ++ATD+DIG N+ + Y I D
Sbjct: 1519 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1578
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS 127
FR+D SG + TR A DRE+ + Y ++ D+ +P
Sbjct: 1579 M-------------------AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT- 1618
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS+T ++V I+D+NDN P F + Y V +DE + +I I+A D D G N +
Sbjct: 1619 --LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-IQALDLDEGPNGTV 1675
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRS-YRLVIRAQDGG---SPSRSNTTQL 243
YAI+ GN F ID G ++ K LDYE Y L++ A D S ++TT +
Sbjct: 1676 TYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1735
Query: 244 LINIRDVNDNAPRF---YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKD 300
L+N+ D+NDN P F Y F+ V+E P G + A+D D G N ++ Y++ D D
Sbjct: 1736 LVNVNDINDNVPTFPRDYEGPFE--VTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGD 1792
Query: 301 YTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
G I P G V +LDRET A Y L + A D G PP S+T
Sbjct: 1793 PLGE----FVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLD 1848
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITS 416
+ + ++E+ P + V + A+DAD + RL + IT GN F I +
Sbjct: 1849 INDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINA 1908
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG-----GRSDTAMVQINITDANNYAPVFEN 471
G ++TV +PLD ++ Y LT+S D+ R D ++ I ++D N+ P+F
Sbjct: 1909 TTG--IVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1966
Query: 472 APYTASVFEDAPIGTTVLVVS----ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ Y A V E++P GT + V++ A D+D I A +TY L S F IN
Sbjct: 1967 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG--------LFDIN 2018
Query: 528 PQTGAITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
TG +T ++DRE S +L + + L+ T + I+++D NDN P F
Sbjct: 2019 SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPAT 2078
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRT-NKA 644
T +++E+ G SV QV ATD D GLNG + Y ++ ++ F+I +GVIR N
Sbjct: 2079 LTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR--FLIHLVTGVIRVGNAT 2136
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
+DRE ++ L VA D GT P S T IV I I+DINDS P F + T + E++ GT
Sbjct: 2137 IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGT 2196
Query: 705 TIGEIRAHDPDEGPNAVVH-YSIKGGDDS--------NSFSLETRQGS------DKAELV 749
I I A D D P H I DD+ ++F++ GS ELV
Sbjct: 2197 VIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELV 2256
Query: 750 TMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIF 801
++ +L R+ S P + ++ + V DVNDN P K F I +
Sbjct: 2257 ATYEVTLSVIDNASDLPERSVSVP---NAKLTVNVLDVNDNTPQFKPFGITY 2305
Score = 347 bits (852), Expect = 5e-94
Identities = 267/859 (31%), Positives = 406/859 (47%), Gaps = 51/859 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND+ P ++ Y ++ E + V T+ A D D+G+N + Y+I+
Sbjct: 771 ITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ------- 823
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P + ++ + R A L R+ ++V TD P +
Sbjct: 824 -PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK------IVVSVTDCGRPPL-KA 875
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+AT+ VN++D NDN P F + V E I + I ++ A D D G N + Y
Sbjct: 876 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVS--IYQVVAIDLDEGLNGLVSYR 933
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ G +M F I+S SG V LD E++ Y+L + A D G+P++S+T+ L I++ DV
Sbjct: 934 MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDV 993
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
ND P F+ +++ SVSE+VP + +V + D D G+NAEL+Y +T GNVD +
Sbjct: 994 NDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG----GNVDGKFS 1049
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR--SATATXXXXXXXXXXXXXXFMP 368
+ R V T LDRET A Y L++ A D G + + TAT F+
Sbjct: 1050 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1109
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRGLITVA 426
YE + ED P G ++ L ATDADE R+ Y I GN F I NG L+
Sbjct: 1110 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGL-LMRGP 1168
Query: 427 QPLDFKQERRYVLTVSA--TDSGGRSDTAMVQINITDANNYAPVFENAPYT-ASVFEDAP 483
+PLD ++ +VL V A D G + V + + D N+ APVF Y+ + E A
Sbjct: 1169 RPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1228
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
IGT+V+VV ATD D G + Y + S + +F I+ TG I T LD ET
Sbjct: 1229 IGTSVIVVQATDRDSGDGGLVNYRILSGA--------EGKFEIDESTGLIITVNYLDYET 1280
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y++ V+A D P V I++++ D F Y A I+E+ +GT + +V
Sbjct: 1281 KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRV 1340
Query: 604 GATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAID 661
A D LN +I Y + + + F ID +GVI +DRE + L VA D
Sbjct: 1341 QAYSID-NLN-QITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADD 1398
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFE-SDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
GG P STV V+I + D ND+ P F+ + I E+ P+G + ++A DPD G N
Sbjct: 1399 GG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNG 1457
Query: 721 VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V +S+ G+ + +F + T S E+ LD E Y L + A+ +PP D
Sbjct: 1458 QVVFSLASGNIAGAFEIVTTNDS-IGEVFVARPLDREE-LDHYILQVVASDRGTPPRKKD 1515
Query: 778 VRVEILVTDVNDNAPVMKD---FQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSG 834
+++ + D+NDN PV++ + + N R D + L Y I G
Sbjct: 1516 HILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEG 1575
Query: 835 NNANLILLNETTGSMTLSP 853
N ++ +G + P
Sbjct: 1576 NKDMAFRMDRISGEIATRP 1594
Score = 338 bits (831), Expect = 2e-91
Identities = 266/889 (29%), Positives = 409/889 (46%), Gaps = 75/889 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 452 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 505
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 506 ---DD------------PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 546
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 547 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 602
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 603 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 662
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 663 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSL 718
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DG G ++ AT
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTG 836
Query: 420 R-----GLITVAQPLDFKQERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFE 470
+ ++ P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 837 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 896
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 897 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSS 949
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 950 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1009
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESV 650
ED V + TD DVGLN + Y + +G F + V+RT LDRE+
Sbjct: 1010 SEDVPREFRVVWLNCTDNDVGLNAELSYFI-TGGNVDGKFSVGYRDAVVRTVVGLDRETT 1068
Query: 651 ATHDLKAVAIDGGT--PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A + L AID G + T V + + D+ND+ P+F + E+ P G +I +
Sbjct: 1069 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1128
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
++A D DEG V Y I G+ N+F + G + LD E + L++
Sbjct: 1129 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG---LLMRGPRPLDRER-NSSHVLIVE 1184
Query: 769 AAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVT 824
A + P+ + VRV + V D+ND APV Q ++ +G V A D D
Sbjct: 1185 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1244
Query: 825 D--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D + YRILSG ++E+TG + L+ M VS TD
Sbjct: 1245 DGGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATD 1292
Score = 336 bits (825), Expect = 9e-91
Identities = 274/889 (30%), Positives = 419/889 (47%), Gaps = 83/889 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASS-GTTVLTLKATDQDIGKNAEVEYTIELVT 66
H + ++D ND++P+F+ YE + EG + T+++T++A D D G N V Y I V
Sbjct: 1624 HVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI--VA 1681
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDRE-KVARYTVLVKATDQASP 125
+ +N FRID G + LD E RYT++V ATDQ
Sbjct: 1682 GNIVN-----------------TFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPI 1724
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+S RL+ST T+ VN+ D NDN P F + Y E P + A D D G N
Sbjct: 1725 LSHRLTSTTTVLVNVNDINDNVPTF-PRDYE-GPFEVTEGQPGPRVWTFLAHDRDSGPNG 1782
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQL 243
+ Y+I+ G+ +F I + G + + K LD E + Y L I A+D G P S+T +
Sbjct: 1783 QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLV 1842
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D+NDN P ++SEN P+ + V A DAD G NA LT+ +T G
Sbjct: 1843 GIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT----AG 1898
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
N + I+ +G V + LDRE +Y+L ++ D + PR A
Sbjct: 1899 NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDEN 1958
Query: 364 X---XFMPGQYEVELAEDEPPGTPVVTLT----ATDADED--NRLHYEITGGNTRGRFSI 414
F Y+ E+ E+ P GTP+ L A DAD+D + Y++ G + G F I
Sbjct: 1959 DNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS-GLFDI 2017
Query: 415 TSQNGRGLITVAQPLDFKQER----RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE 470
S G++TV + +E L + A D G + TA + I I D N+ P F
Sbjct: 2018 NSST--GVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2075
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
A T + E+ P G +VL V+ATD D G+N ++ Y + EA A +F+I+ T
Sbjct: 2076 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGA--QDRFLIHLVT 2127
Query: 531 GAITT-NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
G I N +DRE Y LTV A D G LS T V I + D+ND+ P F + T +
Sbjct: 2128 GVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVS 2187
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYEL------DPKDR----EEGSFVIDPASGVI 639
++E A GT ++ + A D D LN ++ Y + D DR +E +F ++ +G +
Sbjct: 2188 VLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSV 2245
Query: 640 RTNKALDRESVATHDLKAVAIDGGTP-PQSSTVIVHIKIE----DINDSPPVFESDCLTF 694
++RE VAT+++ ID + P+ S + + K+ D+ND+ P F+ +T+
Sbjct: 2246 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2305
Query: 695 Y---ISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
Y I E + GTT+ + A DPD+G N +V Y++ LE S +++
Sbjct: 2306 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE---DSSAGKVIAN 2362
Query: 752 VDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
+DYE +RA+ SPP ++ V + + D+NDN P+ ++D
Sbjct: 2363 RTVDYEEVH-WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFED-V 2420
Query: 809 PVGP-FGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
PVG V A DAD + G+ + +N TTG + + L+
Sbjct: 2421 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2469
Score = 330 bits (811), Expect = 4e-89
Identities = 278/882 (31%), Positives = 411/882 (46%), Gaps = 62/882 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ P+F YEASV E G ++L LKATD D G+ V Y I L
Sbjct: 1095 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI-------L 1147
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRAS-LDREKVARYTVLVKATDQASPVSDR 129
+ FRI +G L+ LDRE+ + + ++V+A +
Sbjct: 1148 HGNHGNN------------FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL---GP 1192
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYT-VSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ S+ + V + D ND P F+++ Y+ + + E + + ++ ++ATD D G +
Sbjct: 1193 MRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIV--VQATDRDSGDGGLVN 1250
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y I+ G + +F ID +G + V LDYE SY + + A D P + I +
Sbjct: 1251 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLL 1309
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
+ D A +F + ++ ++ EN+ +G IVRVQAY D +N ++TY T L
Sbjct: 1310 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN-LN-QITYRFNAYTSTQAKAL- 1366
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
ID +G + G +DRE Y L V A DGG S
Sbjct: 1367 FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFT 1426
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR-GLITV 425
V + ED P G V T+ A D D + ++ + + GN G F I + N G + V
Sbjct: 1427 SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFV 1486
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENA-PYTASVFEDA 482
A+PLD ++ Y+L V A+D G R ++Q+ I D N+ PV E+ Y SV E+
Sbjct: 1487 ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1546
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL-DR 541
GT V+ V ATD D+GIN+ ++Y ++ + D F ++ +G I T DR
Sbjct: 1547 GGGTAVVQVRATDRDIGINSVLSYYITE-------GNKDMAFRMDRISGEIATRPAPPDR 1599
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA-LVGTSV 600
E S Y L T D G P+LS TT V +++VD NDN P+F+Q Y + E + TS+
Sbjct: 1600 ERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSL 1659
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE-SVATHDLKAVA 659
+ A D D G NG + Y + +F ID GVI K LD E S + L A
Sbjct: 1660 ITIQALDLDEGPNGTVTYAI-VAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTA 1718
Query: 660 IDGG---TPPQSSTVIVHIKIEDINDSPPVFESDCL-TFYISENSPIGTTIGEIRAHDPD 715
D + +ST V + + DIND+ P F D F ++E P G + AHD D
Sbjct: 1719 TDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRD 1777
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---P 772
GPN V YSI GD F + +G + V+LD E+ Y L I A P
Sbjct: 1778 SGPNGQVEYSIMDGDPLGEFVISPVEGVLRVR--KDVELDRETIAF-YNLTICARDRGMP 1834
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDAD--VTDKLQY 829
PL + + V I V D+NDN PV+ + + ++ PV F V A DAD +L +
Sbjct: 1835 PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENS-PVSSFVAHVLASDADSGCNARLTF 1893
Query: 830 RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
I +GN +N TTG +T++ L+ + +SV D
Sbjct: 1894 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1935
Score = 327 bits (803), Expect = 4e-88
Identities = 273/868 (31%), Positives = 416/868 (47%), Gaps = 76/868 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +L+ D + F YEA++ E + GT ++ ++A Y+I D L
Sbjct: 1306 ITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQA------------YSI-----DNL 1348
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N + + +F+ID +G + + +DREK YT+ V A D P ++
Sbjct: 1349 N-QITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGP---KV 1403
Query: 131 SSTATIHVNIIDDNDNYPQFS-EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
ST +++ ++D+NDN P+F VS+ ED V +A +KA D D G+N + +
Sbjct: 1404 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQR--VATVKAWDPDAGSNGQVVF 1461
Query: 190 AIIGGNTQMQFSI----DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
++ GN F I DS+ G+V + + LD E++ Y L + A D G+P R L +
Sbjct: 1462 SLASGNIAGAFEIVTTNDSI-GEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQV 1520
Query: 246 NIRDVNDNAPRFYTSL-FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
I D+NDN P + + SV+ENV G ++V+V+A D D G+N+ L+Y +T+ GN
Sbjct: 1521 TILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE----GN 1576
Query: 305 VDLPITIDPRSGWVYTS-GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
D+ +D SG + T DRE Q+ Y L+ T D G P SAT
Sbjct: 1577 KDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNA 1636
Query: 364 XXFMPGQYEVELAED-EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGR 420
F YEV L E + T ++T+ A D DE + + Y I GN F I
Sbjct: 1637 PMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH--M 1694
Query: 421 GLITVAQPLDFK-QERRYVLTVSATD-----SGGRSDTAMVQINITDANNYAPVFEN--- 471
G+IT A+ LD++ RY L V+ATD S + T V +N+ D N+ P F
Sbjct: 1695 GVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYE 1754
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
P+ V E P G V A D D G N Q+ YS+ + + + +FVI+P G
Sbjct: 1755 GPF--EVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSI---MDGDPLG----EFVISPVEG 1804
Query: 532 AITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
+ K LDRET++ Y LT+ ARD G+P LS T V I V+D+NDN+PV
Sbjct: 1805 VLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNIT 1864
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES 649
I E++ V + V+ V A+DAD G N R+ + + +RE +F I+ +G++ N+ LDRE
Sbjct: 1865 ISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRER-AFFINATTGIVTVNRPLDRER 1923
Query: 650 VATHDLKAVAIDGGTPPQSSTV---IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
+ + L D P+ + ++ I + D ND+ P+F + ENSP GT +
Sbjct: 1924 IPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPL 1983
Query: 707 ----GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKK 762
G I A D D+ AVV Y + G S F + + G ++D + SP
Sbjct: 1984 TVLNGPILALDADQDIYAVVTYQLLGAQ-SGLFDINSSTGVVTVRSGVIIDREAFSP-PI 2041
Query: 763 YELVIRAASPPLWNDV-RVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
EL++ A L N + I + D NDN P + + ++C P +V A D
Sbjct: 2042 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2101
Query: 822 D--VTDKLQYRILSGNNANLILLNETTG 847
D + +L YRI +G + L++ TG
Sbjct: 2102 DSGLNGELVYRIEAGAQ-DRFLIHLVTG 2128
Score = 318 bits (780), Expect = 2e-85
Identities = 267/872 (30%), Positives = 418/872 (47%), Gaps = 77/872 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEA-SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+ V D ND +PVF QQY +RE A GT+V+ ++ATD+D G V Y I
Sbjct: 1201 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI------- 1253
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ F ID +G ++T LD E Y + V ATDQA P +
Sbjct: 1254 -------------LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG 1300
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S +++ ++++ D QFS +Y ++ E++++ I +++A D R+
Sbjct: 1301 FCS---VYITLLNELDEAVQFSNASYEAAILENLALGTE--IVRVQAYSIDNLNQITYRF 1355
Query: 190 -AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
A + F ID+++G +++ +D E+ Y L + A DGG P +T ++ I +
Sbjct: 1356 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVL 1414
Query: 249 DVNDNAPRF-YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D NDN+PRF +TS S+ E+ P+G + V+A+D D G N ++ +++ + G ++
Sbjct: 1415 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1474
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF- 366
+T + G V+ + LDRE Y L V A+D G PPR
Sbjct: 1475 -VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIE 1533
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLIT 424
P Y V + E+ GT VV + ATD D ++ L Y IT GN F + +G + T
Sbjct: 1534 SPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE-IAT 1592
Query: 425 VAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
P D +++ Y L + D G S T V + I D N+ AP+F+ P+ + ++
Sbjct: 1593 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ-PHYEVLLDEG 1651
Query: 483 P--IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
P + T+++ + A D D G N +TY++ ++ V F I+ G IT K LD
Sbjct: 1652 PDTLNTSLITIQALDLDEGPNGTVTYAI---VAGNIV----NTFRIDRHMGVITAAKELD 1704
Query: 541 RETMSG-YLLTVTARDGGVPSLS----DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
E G Y L VTA D P LS TT V ++V D+NDN P F + + +
Sbjct: 1705 YEISHGRYTLIVTATDQ-CPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQ 1763
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNK--ALDRESVATH 653
G V A D D G NG++ Y + D G FVI P GV+R K LDRE++A +
Sbjct: 1764 PGPRVWTFLAHDRDSGPNGQVEYSIMDGD-PLGEFVISPVEGVLRVRKDVELDRETIAFY 1822
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
+L A D G PP SST++V I++ DIND+ PV + + ISENSP+ + + + A D
Sbjct: 1823 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1882
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM-VDLDYESPRKKYELVIRAASP 772
D G NA + ++I G+ +F + G +VT+ LD E +Y+L I
Sbjct: 1883 ADSGCNARLTFNITAGNRERAFFINATTG-----IVTVNRPLDRER-IPEYKLTISVKDN 1936
Query: 773 PLWNDVR------VEILVTDVNDNAPVM--KDFQI-IFNNYKDCFPV----GPFGRVPAY 819
P + + I ++D NDN P+ +Q + N P+ GP + A
Sbjct: 1937 PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA- 1995
Query: 820 DADVTDKLQYRILSGNNANLILLNETTGSMTL 851
D D+ + Y++L G + L +N +TG +T+
Sbjct: 1996 DQDIYAVVTYQLL-GAQSGLFDINSSTGVVTV 2026
Score = 305 bits (750), Expect = 1e-81
Identities = 256/901 (28%), Positives = 414/901 (45%), Gaps = 58/901 (6%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 553 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 610
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTV--LVKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 611 FG-------------SYFDISLYEG-YGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-- 654
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 655 -PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 711
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 712 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 771
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM--TDKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 772 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 831
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 832 N-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 890
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +
Sbjct: 891 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS- 949
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 950 -GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1008
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V ED P V+ ++ TD+DVG+NA+++Y ++ + D +F + + + T
Sbjct: 1009 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITG-------GNVDGKFSVGYRDAVVRTVV 1061
Query: 538 LLDRETMSGYLLTVTARDGGVPSL--SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
LDRET + Y+L + A D G + T V ++V+DVNDN P+F Q Y A++ ED
Sbjct: 1062 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIP 1121
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVI-RTNKALDRESVATHD 654
G S+ Q+ ATDAD G GR+ Y + +F I ++G++ R + LDRE ++H
Sbjct: 1122 EGHSILQLKATDADEGEFGRVWYRI-LHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1180
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-ESDCLTFYISENSPIGTTIGEIRAHD 713
L A + P S+V V + +EDIND PVF + + E + IGT++ ++A D
Sbjct: 1181 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATD 1240
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPP 773
D G +V+Y I G + F ++ G ++T+ LDYE+ V P
Sbjct: 1241 RDSGDGGLVNYRILSGAE-GKFEIDESTGL----IITVNYLDYETKTSYMMNVSATDQAP 1295
Query: 774 LWNDVRVEILVTDVN--DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRI 831
+N + +T +N D A + ++ RV AY D +++ YR
Sbjct: 1296 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRF 1355
Query: 832 ---LSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLIT 888
S L ++ TG +T+ ++ T+ V DG ++ + +++ + ++
Sbjct: 1356 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLD 1415
Query: 889 E 889
E
Sbjct: 1416 E 1416
Score = 295 bits (725), Expect = 1e-78
Identities = 238/779 (30%), Positives = 370/779 (47%), Gaps = 71/779 (9%)
Query: 15 DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPED 74
D ND P F SV E A GT + + A D D+ N ++EY I + A +D
Sbjct: 2171 DINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAK----DD 2224
Query: 75 AXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSST- 133
+D F ++ +G+++ ++ ++RE VA Y V + D AS + +R S
Sbjct: 2225 TDRLVPNQ----EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2280
Query: 134 -ATIHVNIIDDNDNYPQFSEKTYTVSVDEDIS-VTDNPVIAKIKATDADVGANSAIRYAI 191
A + VN++D NDN PQF T ++ + T + + A D D G N + Y +
Sbjct: 2281 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 2340
Query: 192 IG----GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ G Q++ DS +G V +T+DYE+V +RA D GSP R+ + + I
Sbjct: 2341 LDLVPPGYVQLE---DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 2397
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D+NDN P F +QE+V E+VP+G I+ V A DAD G A + Y++ G+ +
Sbjct: 2398 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL------GDGES 2451
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG-GDPP---RSATATXXXXXXXXXXXX 363
I+P +G +Y LDRE + Y L A D GD R +
Sbjct: 2452 KFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCR 2511
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F Q+ + E+EP GT V+T+ ATD DE + L Y + G F + + G
Sbjct: 2512 PQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDS--G 2568
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAP--YTAS 477
L+T +PL + ++ LTV ATD G T M+ + + D N+ PVF P
Sbjct: 2569 LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILH 2626
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ P+ + V V ATD D G+N + YS N + F+I+P +G I T +
Sbjct: 2627 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGN----RDWEFFIIDPISGLIQTAQ 2682
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVF------KQQLYTANI 590
LDRE+ + Y L + A D G P +T +++++ D++DNEP+F Q +
Sbjct: 2683 RLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2742
Query: 591 MEDALVGTSVSQV-GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALD--R 647
E + GT V V GA DAD G N ++Y + EE +F + P G + + LD R
Sbjct: 2743 PEHSPRGTLVGNVTGAVDADEGPNAIVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDRER 2800
Query: 648 ESVATHDLKAVAIDGGTPPQ--SSTV---------IVHIKIEDINDSPPVFESDCLTFYI 696
E++ + +KA + TPP+ S T+ V + +EDIND PP F T +
Sbjct: 2801 EAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2860
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD 755
+ ++ +G+ + ++ A D D G N++V YSI + F D ++ TM +D
Sbjct: 2861 ATDAKVGSELIQVLALDADIGNNSLVFYSILA---IHYFRALANDSEDVGQVFTMGSMD 2916
Score = 287 bits (703), Expect = 5e-76
Identities = 247/820 (30%), Positives = 373/820 (45%), Gaps = 85/820 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ PV ++ E + + V + A+D D G NA + + I TA
Sbjct: 1844 IRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAG-- 1898
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N E A F I+ +G + LDRE++ Y + + D +P + R+
Sbjct: 1899 NRERA--------------FFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPRI 1942
Query: 131 SSTA--TIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIA---KIKATDADVGANS 185
+ + + + D+NDN+P F++ TY V E+ S P+ I A DAD +
Sbjct: 1943 ARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMEN-SPAGTPLTVLNGPILALDADQDIYA 2001
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRS--YRLVIRAQDGGSPSRSNTT 241
+ Y ++G + + F I+S +G V++ +D E L++ A+D G ++T
Sbjct: 2002 VVTYQLLGAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTA 2058
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
LLI I D NDN P F + + EN P G+S+++V A D D G+N EL Y +
Sbjct: 2059 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ 2118
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+ +T R G + +DRE Q Y+L V ATD G P S TA
Sbjct: 2119 DRFLIHLVTGVIRVG----NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIND 2174
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITG-----------GNTRG 410
F+ V + E PGT + +TA D D + +L Y I G N
Sbjct: 2175 SRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQED 2234
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG----RS---DTAMVQINITDAN 463
F++ G + V P++ + Y +T+S D+ RS A + +N+ D N
Sbjct: 2235 AFAVNINTGS--VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVN 2292
Query: 464 NYAPVFEN---APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH 520
+ P F+ Y + E A GTT++ V+A D D G+N +TY+L + V
Sbjct: 2293 DNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2352
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
D G + N+ +D E + TV A D G P + V + +VD+NDN P+
Sbjct: 2353 DSS------AGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPI 2406
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR 640
F Q Y + ED VGT + V ATDAD G I Y L E F I+P +G I
Sbjct: 2407 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG---ESKFAINPTTGDIY 2463
Query: 641 TNKALDRESVATHDLKAVAIDG----GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYI 696
+LDRE + L A+A D + + ++V V I++ D+ND P F + +
Sbjct: 2464 VLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSV 2523
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDY 756
EN P GT++ + A D DEGPN + YS++G +F ++ G LVT
Sbjct: 2524 YENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEAFHVDMDSG-----LVT-TQRPL 2576
Query: 757 ESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPV 793
+S +K+ L + A PPLW + + V DVNDN PV
Sbjct: 2577 QS-YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPV 2615
Score = 271 bits (664), Expect = 3e-71
Identities = 254/874 (29%), Positives = 394/874 (45%), Gaps = 82/874 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPV---IAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
F + Y+V + E + + PV I + ATD D+GA ++ Y+ F+IDS
Sbjct: 132 FHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSAR 189
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQES 265
G V++++ LDYE ++Y+L + A D +T L I I DV D P F + +
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTN 249
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E+ P G ++ + A D D+G + YT+ GN + +D SG + +G LD
Sbjct: 250 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV--SVAGNTNSIFALDYISGVLTLNGLLD 307
Query: 326 RET---QAKYQLLVTATDGGD--PPRSATATXXXXXXXXXXXXXX--FMPGQYEVELAED 378
RE + L V T+ D P AT T F +Y V + E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 379 EPPGTPV-VTLTATDADEDNRLHYEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFK 432
G + + + D DE +E+ GN F I TS G+ I VA PLD++
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 427
Query: 433 QERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVV 491
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 428 TVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 487
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 488 LATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTI 538
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 539 IARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP 596
Query: 612 LNGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQ 667
N +I Y + F I GVI ++ LD E ++ L +A+D G PP
Sbjct: 597 PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL 656
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVH 723
+STV V I++ D ND+PP F + EN G T+ + A D D G +++
Sbjct: 657 NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII- 715
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR---- 779
YS++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 716 YSLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIA 767
Query: 780 -VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNN 836
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 768 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN- 826
Query: 837 ANLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLIT 888
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 827 -KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV---- 881
Query: 889 EEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 882 ---FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 910
Score = 267 bits (655), Expect = 3e-70
Identities = 252/881 (28%), Positives = 393/881 (44%), Gaps = 76/881 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVRE-GASS----GTTVLTLKATDQDIGKNAEVEYTIELV 65
I V D ND++P F Q Y + E GA+ GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ-- 177
Query: 66 TADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASP 125
P F ID G + LD E Y + V ATDQ
Sbjct: 178 ------PPS-------------QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK- 217
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ LS+ A + + I D D P F Y+ ++ E + I A D D G
Sbjct: 218 -TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP--PGTTVRIITAIDQDKGRPR 274
Query: 186 AIRYAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSR 237
I Y I+ GNT F++D +SG ++L LD E + S+ ++ + D +PS
Sbjct: 275 GIGYTIVSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 334
Query: 238 SN-TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADEGVNAELTYT 295
+ TT I + D+NDNAP F +S + +++E +G+++ + +Q D DEG+N+
Sbjct: 335 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVY 394
Query: 296 MTDKDYTGNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ + + P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV-PDHVGYAKVKI 453
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSI 414
F Y + L E+ GT V+T+ ATD D + RFS+
Sbjct: 454 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSL 513
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPY 474
G LI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y
Sbjct: 514 DKDTG--LIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
++ E+ P T ++ + ATD D N QITYS+ +S A + + G I+
Sbjct: 572 VGALRENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVIS 627
Query: 535 TNKLLDRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
++ LD E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E
Sbjct: 628 VSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVE 687
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESV 650
+ + G +V + ATD D R + + EGS F I+ SG I T LDRE+
Sbjct: 688 NIMAGATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETK 744
Query: 651 ATHDLKAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
+ + L A+DGG T I V+I + DIND+ P ++ + E +P + +
Sbjct: 745 SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTT 804
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------R 760
+ A DPD G N + YSI+ + +SL + G + T LD E+P R
Sbjct: 805 VVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMR 859
Query: 761 KKYELVIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVP 817
K V PPL + V + + D+NDN P ++ + + P G +V
Sbjct: 860 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVV 918
Query: 818 AYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
A D D + + YR+ G L+N ++G + + +L+
Sbjct: 919 AIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 959
Score = 179 bits (436), Expect = 1e-43
Identities = 166/569 (29%), Positives = 256/569 (44%), Gaps = 61/569 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEE----ASRFFAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + + D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVS---DHQGVITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAE-----DEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLI 423
+ E + P GTP+ + ATD D GG+ F SQ + RG++
Sbjct: 140 RIPEVGATGNTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIV 192
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFE 480
TV + LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E
Sbjct: 193 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+P GTTV +++A D D G I Y++ S N + F ++ +G +T N LLD
Sbjct: 253 HSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNT-----NSIFALDYISGVLTLNGLLD 307
Query: 541 RET---MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMED 593
RE G++LTV D PS + TT I V+D+NDN P F Y+ I E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 594 ALVGTSVSQ-VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALD 646
A VG ++ + D D GLN +E+ F+I P S IR LD
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 425
Query: 647 RESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E+V +D A + P V I + + ND+ P+F + EN +GT++
Sbjct: 426 YETVDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 484
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
+ A D D G V Y DD + FSL+ D ++ + LDYE ++ +
Sbjct: 485 LTVLATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTI 538
Query: 767 IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
I RV I V DVNDN P +
Sbjct: 539 IARDGGGEETTGRVRINVLDVNDNVPTFQ 567
Score = 172 bits (418), Expect = 2e-41
Identities = 143/518 (27%), Positives = 233/518 (44%), Gaps = 30/518 (5%)
Query: 375 LAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQE 434
++ED P G+ V L A D D D L + ++G F++ G ++ + QPLD + +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDP-LVFGVSGEEASRFFAVEPDTG--VVWLRQPLDRETK 98
Query: 435 RRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFE-----DAPIGTTVL 489
+ + S +D G T V I + D N+ AP F N PY+ + E + P+GT +
Sbjct: 99 SEFTVEFSVSDHQGVI-TRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIF 157
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
+V+ATD D+G + YS Q F I+ G +T + LD ET Y L
Sbjct: 158 IVNATDPDLGAGGSVLYSFQPP---------SQFFAIDSARGIVTVIRELDYETTQAYQL 208
Query: 550 TVTARD-GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDA 608
TV A D LS ++ I + DV D +P+F Y+ NI E + GT+V + A D
Sbjct: 209 TVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 268
Query: 609 DVGLNGRIHYEL-DPKDREEGSFVIDPASGVIRTNKALDRES-VATH----DLKAVAIDG 662
D G I Y + F +D SGV+ N LDRE+ + +H +K ++
Sbjct: 269 DKGRPRGIGYTIVSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELND 328
Query: 663 GTPPQSSTVIV--HIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDEGPN 719
P +TV +I + DIND+ P F S + I+E + +G + I+ D DEG N
Sbjct: 329 DRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLN 388
Query: 720 AVVHYSIKGGDDSNSFSLETR-QGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWND 777
++ + G + + T QG + + LDYE+ R ++L + P
Sbjct: 389 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGY 448
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA 837
+V+I + + NDN P+ + Y++ V A D D + ++
Sbjct: 449 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP 508
Query: 838 NLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNE 875
+ L++ TG + L +L+ + + T+ + DG E
Sbjct: 509 DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE 546
Score = 124 bits (298), Expect = 6e-27
Identities = 120/406 (29%), Positives = 182/406 (44%), Gaps = 45/406 (11%)
Query: 464 NYAPVFENAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHD 521
N P F N + + ED P+G++V + A D D N + + +S E EA
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGE---EA----S 75
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG-GVPSLSDTTDVEISVVDVNDNEPV 580
+ F + P TG + + LDRET S + + + D GV T V I V DVNDN P
Sbjct: 76 RFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI----TRKVNIQVGDVNDNAPT 131
Query: 581 FKQQLYTANIME-----DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPA 635
F Q Y+ I E + VGT + V ATD D+G G + Y P + F ID A
Sbjct: 132 FHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ---FFAIDSA 188
Query: 636 SGVIRTNKALDRESVATHDLKAVAID-GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
G++ + LD E+ + L A D T P S+ + I I D+ D P+F + +
Sbjct: 189 RGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYST 248
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSI--KGGDDSNSFSLETRQGSDKAELVTMV 752
I E+SP GTT+ I A D D+G + Y+I G+ ++ F+L+ G L
Sbjct: 249 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSIFALDYISG----VLTLNG 304
Query: 753 DLDYESPRKKYELVIRAASPPLWND---------VRVEILVTDVNDNAPVM--KDFQIIF 801
LD E+P + ++ L +D ILV D+NDNAP ++ +
Sbjct: 305 LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAI 364
Query: 802 NNYKDC-FPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETT 846
F + F +V D + + L GNN++ +++ T+
Sbjct: 365 TELAQVGFALPLFIQVVDKDEGLNSMFEV-YLVGNNSHHFIISPTS 409
Score = 89.4 bits (212), Expect = 2e-16
Identities = 82/304 (26%), Positives = 131/304 (43%), Gaps = 35/304 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEA--SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
+ V+D ND+ PVF +RE + V + ATD+D G N V Y+ L TA
Sbjct: 2604 VEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF-LKTAG 2662
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ E F ID SG + T LDRE A Y++++ A+D PV
Sbjct: 2663 NRDWE---------------FFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY 2707
Query: 129 RLSSTATIHVNIIDDNDNY---PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ + IDDN+ P Y + + S V A DAD G N+
Sbjct: 2708 ETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNA 2767
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQD--------GGSPSR 237
+ Y I GN + F + G + +++ LD E+ + +++A G SP+
Sbjct: 2768 IVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTL 2826
Query: 238 SNTTQLLIN-----IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAEL 292
L + + D+ND PRF + + V+ + +G +++V A DAD G N+ +
Sbjct: 2827 DLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLV 2886
Query: 293 TYTM 296
Y++
Sbjct: 2887 FYSI 2890
>AY010111-1|AAG27034.2| 3354|Homo sapiens cadherin 23 protein.
Length = 3354
Score = 355 bits (872), Expect = 2e-96
Identities = 274/879 (31%), Positives = 424/879 (48%), Gaps = 59/879 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+N+LD ND+ P F+ + A V EG +G ++ + A D D G N V Y + V +
Sbjct: 878 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP-VGMPRM 936
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F I+ SG ++T LDRE++A Y + V A+D +P
Sbjct: 937 D------------------FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK--- 975
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SST+T+ ++++D ND P F Y VSV ED+ + + TD DVG N+ + Y
Sbjct: 976 SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR--VVWLNCTDNDVGLNAELSYF 1033
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR--SNTTQLLINIR 248
I GGN +FS+ V V LD E +Y L++ A D G + + T + + +
Sbjct: 1034 ITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL 1093
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F S ++ SV E++P G+SI++++A DADEG + Y + ++ N +
Sbjct: 1094 DVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIH 1153
Query: 309 ITIDPRSGWVYTSGQ-LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++ +G + + LDRE + + L+V A + P ++ F
Sbjct: 1154 VS----NGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT 1209
Query: 368 PGQY-EVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
QY + L E GT V+ + ATD D + ++Y I G G+F I GLI
Sbjct: 1210 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEI--DESTGLII 1266
Query: 425 VAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDAN--NYAPVFENAPYTASVFEDA 482
LD++ + Y++ VSATD + + IT N + A F NA Y A++ E+
Sbjct: 1267 TVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENL 1326
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
+GT ++ V A D +N QITY + S +A A F I+ TG IT L+DRE
Sbjct: 1327 ALGTEIVRVQAYSID-NLN-QITYRFDAYTSTQAKA----LFKIDAITGVITVQGLVDRE 1380
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA-NIMEDALVGTSVS 601
Y LTV A DGG P + T V I+V+D NDN P F +A +I ED VG V+
Sbjct: 1381 KGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVA 1439
Query: 602 QVGATDADVGLNGRIHYELDPKDREEGSFVI---DPASGVIRTNKALDRESVATHDLKAV 658
V A D D G NG++ + L G+F I + + G + + LDRE + + L+ V
Sbjct: 1440 TVKAWDPDAGSNGQVVFSL-ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVV 1498
Query: 659 AIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC-LTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP+ I+ + I DIND+PPV ES ++EN GT + ++RA D D G
Sbjct: 1499 ASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIG 1558
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
N+V+ Y I G+ +F ++ R + A D + +S V +P L
Sbjct: 1559 INSVLSYYITEGNKDMTFRMD-RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSAT 1617
Query: 778 VRVEILVTDVNDNAPVMKD--FQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILS 833
V + + D NDNAP+ + ++++ + D + A D D + Y I++
Sbjct: 1618 THVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEGPNGTVTYAIVA 1676
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPK-LATMEVSVTD 871
GN N ++ G +T + +L+ + T+ V+ TD
Sbjct: 1677 GNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATD 1715
Score = 350 bits (861), Expect = 4e-95
Identities = 274/832 (32%), Positives = 400/832 (48%), Gaps = 85/832 (10%)
Query: 10 QINVLDCNDHSPVFEMQ-QYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
Q+ +LD ND+ PV E Y SV E GT V+ ++ATD+DIG N+ + Y I D
Sbjct: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS 127
FR+D SG + TR A DRE+ + Y ++ D+ +P
Sbjct: 1574 M-------------------TFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT- 1613
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS+T ++V I+D+NDN P F + Y V +DE + +I I+A D D G N +
Sbjct: 1614 --LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-IQALDLDEGPNGTV 1670
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRS-YRLVIRAQDGG---SPSRSNTTQL 243
YAI+ GN F ID G ++ K LDYE Y L++ A D S ++TT +
Sbjct: 1671 TYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1730
Query: 244 LINIRDVNDNAPRF---YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKD 300
L+N+ D+NDN P F Y F+ V+E P G + A+D D G N ++ Y++ D D
Sbjct: 1731 LVNVNDINDNVPTFPRDYEGPFE--VTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGD 1787
Query: 301 YTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
G I P G V +LDRET A Y L + A D G PP S+T
Sbjct: 1788 PLGE----FVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLD 1843
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITS 416
+ + ++E+ P + V + A+DAD + RL + IT GN F I +
Sbjct: 1844 INDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINA 1903
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG-----GRSDTAMVQINITDANNYAPVFEN 471
G ++TV +PLD ++ Y LT+S D+ R D ++ I ++D N+ P+F
Sbjct: 1904 TTG--IVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1961
Query: 472 APYTASVFEDAPIGTTVLVVS----ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ Y A V E++P GT + V++ A D+D I A +TY L S F IN
Sbjct: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG--------LFDIN 2013
Query: 528 PQTGAITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
TG +T ++DRE S +L + + L+ T + I+++D NDN P F
Sbjct: 2014 SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPAT 2073
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRT-NKA 644
T +++E+ G SV QV ATD D GLNG + Y ++ ++ F+I +GVIR N
Sbjct: 2074 LTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR--FLIHLVTGVIRVGNAT 2131
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
+DRE ++ L VA D GT P S T IV I I+DINDS P F + T + E++ GT
Sbjct: 2132 IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGT 2191
Query: 705 TIGEIRAHDPDEGPNAVVH-YSIKGGDDS--------NSFSLETRQGS------DKAELV 749
I I A D D P H I DD+ ++F++ GS ELV
Sbjct: 2192 VIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELV 2251
Query: 750 TMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIF 801
++ +L R+ S P + ++ + V DVNDN P K F I +
Sbjct: 2252 ATYEVTLSVIDNASDLPERSVSVP---NAKLTVNVLDVNDNTPQFKPFGITY 2300
Score = 349 bits (857), Expect = 1e-94
Identities = 268/859 (31%), Positives = 406/859 (47%), Gaps = 51/859 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND+ P ++ Y ++ E + V T+ A D D+G+N + Y+I+
Sbjct: 766 ITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ------- 818
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P + ++ + R A L R+ ++V TD P +
Sbjct: 819 -PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK------IVVSVTDCGRPPL-KA 870
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+AT+ VN++D NDN P F + V E I + I ++ A D D G N + Y
Sbjct: 871 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVS--IYQVVAIDLDEGLNGLVSYR 928
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ G +M F I+S SG V LD E++ Y+L + A D G+P++S+T+ L I++ DV
Sbjct: 929 MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDV 988
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
ND P F+ +++ SVSE+VP + +V + D D G+NAEL+Y +T GNVD +
Sbjct: 989 NDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG----GNVDGKFS 1044
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR--SATATXXXXXXXXXXXXXXFMP 368
+ R V T LDRET A Y L++ A D G + + TAT F+
Sbjct: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRGLITVA 426
YE + ED P G ++ L ATDADE R+ Y I GN F I NG L+
Sbjct: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGL-LMRGP 1163
Query: 427 QPLDFKQERRYVLTVSA--TDSGGRSDTAMVQINITDANNYAPVFENAPYT-ASVFEDAP 483
+PLD ++ +VL V A D G + V + + D N+ APVF Y+ + E A
Sbjct: 1164 RPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1223
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
IGT+V+VV ATD D G + Y + S + +F I+ TG I T LD ET
Sbjct: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGA--------EGKFEIDESTGLIITVNYLDYET 1275
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y++ V+A D P V I++++ D F Y A I+E+ +GT + +V
Sbjct: 1276 KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRV 1335
Query: 604 GATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAID 661
A D LN +I Y D + + F ID +GVI +DRE + L VA D
Sbjct: 1336 QAYSID-NLN-QITYRFDAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADD 1393
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFE-SDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
GG P STV V+I + D ND+ P F+ + I E+ P+G + ++A DPD G N
Sbjct: 1394 GG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNG 1452
Query: 721 VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V +S+ G+ + +F + T S E+ LD E Y L + A+ +PP D
Sbjct: 1453 QVVFSLASGNIAGAFEIVTTNDS-IGEVFVARPLDREE-LDHYILQVVASDRGTPPRKKD 1510
Query: 778 VRVEILVTDVNDNAPVMKD---FQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSG 834
+++ + D+NDN PV++ + + N R D + L Y I G
Sbjct: 1511 HILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEG 1570
Query: 835 NNANLILLNETTGSMTLSP 853
N ++ +G + P
Sbjct: 1571 NKDMTFRMDRISGEIATRP 1589
Score = 338 bits (831), Expect = 2e-91
Identities = 266/889 (29%), Positives = 409/889 (46%), Gaps = 75/889 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 500
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 501 ---DD------------PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 541
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 542 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 597
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 598 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 657
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 658 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSL 713
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DG G ++ AT
Sbjct: 714 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 773
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 774 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTG 831
Query: 420 R-----GLITVAQPLDFKQERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFE 470
+ ++ P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 832 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 892 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSS 944
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 945 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1004
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESV 650
ED V + TD DVGLN + Y + +G F + V+RT LDRE+
Sbjct: 1005 SEDVPREFRVVWLNCTDNDVGLNAELSYFI-TGGNVDGKFSVGYRDAVVRTVVGLDRETT 1063
Query: 651 ATHDLKAVAIDGGT--PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A + L AID G + T V + + D+ND+ P+F + E+ P G +I +
Sbjct: 1064 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1123
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
++A D DEG V Y I G+ N+F + G + LD E + L++
Sbjct: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG---LLMRGPRPLDRER-NSSHVLIVE 1179
Query: 769 AAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVT 824
A + P+ + VRV + V D+ND APV Q ++ +G V A D D
Sbjct: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
Query: 825 D--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D + YRILSG ++E+TG + L+ M VS TD
Sbjct: 1240 DGGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATD 1287
Score = 336 bits (825), Expect = 9e-91
Identities = 274/889 (30%), Positives = 419/889 (47%), Gaps = 83/889 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASS-GTTVLTLKATDQDIGKNAEVEYTIELVT 66
H + ++D ND++P+F+ YE + EG + T+++T++A D D G N V Y I V
Sbjct: 1619 HVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI--VA 1676
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDRE-KVARYTVLVKATDQASP 125
+ +N FRID G + LD E RYT++V ATDQ
Sbjct: 1677 GNIVN-----------------TFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPI 1719
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+S RL+ST T+ VN+ D NDN P F + Y E P + A D D G N
Sbjct: 1720 LSHRLTSTTTVLVNVNDINDNVPTF-PRDYE-GPFEVTEGQPGPRVWTFLAHDRDSGPNG 1777
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQL 243
+ Y+I+ G+ +F I + G + + K LD E + Y L I A+D G P S+T +
Sbjct: 1778 QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLV 1837
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D+NDN P ++SEN P+ + V A DAD G NA LT+ +T G
Sbjct: 1838 GIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT----AG 1893
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
N + I+ +G V + LDRE +Y+L ++ D + PR A
Sbjct: 1894 NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDEN 1953
Query: 364 X---XFMPGQYEVELAEDEPPGTPVVTLT----ATDADED--NRLHYEITGGNTRGRFSI 414
F Y+ E+ E+ P GTP+ L A DAD+D + Y++ G + G F I
Sbjct: 1954 DNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS-GLFDI 2012
Query: 415 TSQNGRGLITVAQPLDFKQER----RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE 470
S G++TV + +E L + A D G + TA + I I D N+ P F
Sbjct: 2013 NSST--GVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2070
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
A T + E+ P G +VL V+ATD D G+N ++ Y + EA A +F+I+ T
Sbjct: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGA--QDRFLIHLVT 2122
Query: 531 GAITT-NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
G I N +DRE Y LTV A D G LS T V I + D+ND+ P F + T +
Sbjct: 2123 GVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVS 2182
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYEL------DPKDR----EEGSFVIDPASGVI 639
++E A GT ++ + A D D LN ++ Y + D DR +E +F ++ +G +
Sbjct: 2183 VLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSV 2240
Query: 640 RTNKALDRESVATHDLKAVAIDGGTP-PQSSTVIVHIKIE----DINDSPPVFESDCLTF 694
++RE VAT+++ ID + P+ S + + K+ D+ND+ P F+ +T+
Sbjct: 2241 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2300
Query: 695 Y---ISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
Y I E + GTT+ + A DPD+G N +V Y++ LE S +++
Sbjct: 2301 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE---DSSAGKVIAN 2357
Query: 752 VDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
+DYE +RA+ SPP ++ V + + D+NDN P+ ++D
Sbjct: 2358 RTVDYEEVH-WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFED-V 2415
Query: 809 PVGP-FGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
PVG V A DAD + G+ + +N TTG + + L+
Sbjct: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2464
Score = 330 bits (811), Expect = 4e-89
Identities = 277/882 (31%), Positives = 411/882 (46%), Gaps = 62/882 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ P+F YEASV E G ++L LKATD D G+ V Y I L
Sbjct: 1090 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI-------L 1142
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRAS-LDREKVARYTVLVKATDQASPVSDR 129
+ FRI +G L+ LDRE+ + + ++V+A +
Sbjct: 1143 HGNHGNN------------FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL---GP 1187
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYT-VSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ S+ + V + D ND P F+++ Y+ + + E + + ++ ++ATD D G +
Sbjct: 1188 MRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIV--VQATDRDSGDGGLVN 1245
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y I+ G + +F ID +G + V LDYE SY + + A D P + I +
Sbjct: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLL 1304
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
+ D A +F + ++ ++ EN+ +G IVRVQAY D +N ++TY D +
Sbjct: 1305 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN-LN-QITYRF-DAYTSTQAKAL 1361
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
ID +G + G +DRE Y L V A DGG S
Sbjct: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFT 1421
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR-GLITV 425
V + ED P G V T+ A D D + ++ + + GN G F I + N G + V
Sbjct: 1422 SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFV 1481
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENA-PYTASVFEDA 482
A+PLD ++ Y+L V A+D G R ++Q+ I D N+ PV E+ Y SV E+
Sbjct: 1482 ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1541
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL-DR 541
GT V+ V ATD D+GIN+ ++Y ++ + D F ++ +G I T DR
Sbjct: 1542 GGGTAVVQVRATDRDIGINSVLSYYITE-------GNKDMTFRMDRISGEIATRPAPPDR 1594
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA-LVGTSV 600
E S Y L T D G P+LS TT V +++VD NDN P+F+Q Y + E + TS+
Sbjct: 1595 ERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSL 1654
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE-SVATHDLKAVA 659
+ A D D G NG + Y + +F ID GVI K LD E S + L A
Sbjct: 1655 ITIQALDLDEGPNGTVTYAI-VAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTA 1713
Query: 660 IDGG---TPPQSSTVIVHIKIEDINDSPPVFESDCL-TFYISENSPIGTTIGEIRAHDPD 715
D + +ST V + + DIND+ P F D F ++E P G + AHD D
Sbjct: 1714 TDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRD 1772
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---P 772
GPN V YSI GD F + +G + V+LD E+ Y L I A P
Sbjct: 1773 SGPNGQVEYSIMDGDPLGEFVISPVEGVLRVR--KDVELDRETIAF-YNLTICARDRGMP 1829
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDAD--VTDKLQY 829
PL + + V I V D+NDN PV+ + + ++ PV F V A DAD +L +
Sbjct: 1830 PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENS-PVSSFVAHVLASDADSGCNARLTF 1888
Query: 830 RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
I +GN +N TTG +T++ L+ + +SV D
Sbjct: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
Score = 327 bits (803), Expect = 4e-88
Identities = 273/868 (31%), Positives = 416/868 (47%), Gaps = 76/868 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +L+ D + F YEA++ E + GT ++ ++A Y+I D L
Sbjct: 1301 ITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQA------------YSI-----DNL 1343
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N + + +F+ID +G + + +DREK YT+ V A D P ++
Sbjct: 1344 N-QITYRFDAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGP---KV 1398
Query: 131 SSTATIHVNIIDDNDNYPQFS-EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
ST +++ ++D+NDN P+F VS+ ED V +A +KA D D G+N + +
Sbjct: 1399 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQR--VATVKAWDPDAGSNGQVVF 1456
Query: 190 AIIGGNTQMQFSI----DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
++ GN F I DS+ G+V + + LD E++ Y L + A D G+P R L +
Sbjct: 1457 SLASGNIAGAFEIVTTNDSI-GEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQV 1515
Query: 246 NIRDVNDNAPRFYTSL-FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
I D+NDN P + + SV+ENV G ++V+V+A D D G+N+ L+Y +T+ GN
Sbjct: 1516 TILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE----GN 1571
Query: 305 VDLPITIDPRSGWVYTS-GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
D+ +D SG + T DRE Q+ Y L+ T D G P SAT
Sbjct: 1572 KDMTFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNA 1631
Query: 364 XXFMPGQYEVELAED-EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGR 420
F YEV L E + T ++T+ A D DE + + Y I GN F I
Sbjct: 1632 PMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH--M 1689
Query: 421 GLITVAQPLDFK-QERRYVLTVSATD-----SGGRSDTAMVQINITDANNYAPVFEN--- 471
G+IT A+ LD++ RY L V+ATD S + T V +N+ D N+ P F
Sbjct: 1690 GVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYE 1749
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
P+ V E P G V A D D G N Q+ YS+ + + + +FVI+P G
Sbjct: 1750 GPF--EVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSI---MDGDPLG----EFVISPVEG 1799
Query: 532 AITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
+ K LDRET++ Y LT+ ARD G+P LS T V I V+D+NDN+PV
Sbjct: 1800 VLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNIT 1859
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES 649
I E++ V + V+ V A+DAD G N R+ + + +RE +F I+ +G++ N+ LDRE
Sbjct: 1860 ISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRER-AFFINATTGIVTVNRPLDRER 1918
Query: 650 VATHDLKAVAIDGGTPPQSSTV---IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
+ + L D P+ + ++ I + D ND+ P+F + ENSP GT +
Sbjct: 1919 IPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPL 1978
Query: 707 ----GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKK 762
G I A D D+ AVV Y + G S F + + G ++D + SP
Sbjct: 1979 TVLNGPILALDADQDIYAVVTYQLLGAQ-SGLFDINSSTGVVTVRSGVIIDREAFSP-PI 2036
Query: 763 YELVIRAASPPLWNDV-RVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
EL++ A L N + I + D NDN P + + ++C P +V A D
Sbjct: 2037 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
Query: 822 D--VTDKLQYRILSGNNANLILLNETTG 847
D + +L YRI +G + L++ TG
Sbjct: 2097 DSGLNGELVYRIEAGAQ-DRFLIHLVTG 2123
Score = 318 bits (780), Expect = 2e-85
Identities = 267/872 (30%), Positives = 418/872 (47%), Gaps = 77/872 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEA-SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+ V D ND +PVF QQY +RE A GT+V+ ++ATD+D G V Y I
Sbjct: 1196 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI------- 1248
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ F ID +G ++T LD E Y + V ATDQA P +
Sbjct: 1249 -------------LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG 1295
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S +++ ++++ D QFS +Y ++ E++++ I +++A D R+
Sbjct: 1296 FCS---VYITLLNELDEAVQFSNASYEAAILENLALGTE--IVRVQAYSIDNLNQITYRF 1350
Query: 190 -AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
A + F ID+++G +++ +D E+ Y L + A DGG P +T ++ I +
Sbjct: 1351 DAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVL 1409
Query: 249 DVNDNAPRF-YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D NDN+PRF +TS S+ E+ P+G + V+A+D D G N ++ +++ + G ++
Sbjct: 1410 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1469
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF- 366
+T + G V+ + LDRE Y L V A+D G PPR
Sbjct: 1470 -VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIE 1528
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLIT 424
P Y V + E+ GT VV + ATD D ++ L Y IT GN F + +G + T
Sbjct: 1529 SPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMTFRMDRISGE-IAT 1587
Query: 425 VAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
P D +++ Y L + D G S T V + I D N+ AP+F+ P+ + ++
Sbjct: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ-PHYEVLLDEG 1646
Query: 483 P--IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
P + T+++ + A D D G N +TY++ ++ V F I+ G IT K LD
Sbjct: 1647 PDTLNTSLITIQALDLDEGPNGTVTYAI---VAGNIV----NTFRIDRHMGVITAAKELD 1699
Query: 541 RETMSG-YLLTVTARDGGVPSLS----DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
E G Y L VTA D P LS TT V ++V D+NDN P F + + +
Sbjct: 1700 YEISHGRYTLIVTATDQ-CPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQ 1758
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNK--ALDRESVATH 653
G V A D D G NG++ Y + D G FVI P GV+R K LDRE++A +
Sbjct: 1759 PGPRVWTFLAHDRDSGPNGQVEYSIMDGD-PLGEFVISPVEGVLRVRKDVELDRETIAFY 1817
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
+L A D G PP SST++V I++ DIND+ PV + + ISENSP+ + + + A D
Sbjct: 1818 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1877
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM-VDLDYESPRKKYELVIRAASP 772
D G NA + ++I G+ +F + G +VT+ LD E +Y+L I
Sbjct: 1878 ADSGCNARLTFNITAGNRERAFFINATTG-----IVTVNRPLDRER-IPEYKLTISVKDN 1931
Query: 773 PLWNDVR------VEILVTDVNDNAPVM--KDFQI-IFNNYKDCFPV----GPFGRVPAY 819
P + + I ++D NDN P+ +Q + N P+ GP + A
Sbjct: 1932 PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA- 1990
Query: 820 DADVTDKLQYRILSGNNANLILLNETTGSMTL 851
D D+ + Y++L G + L +N +TG +T+
Sbjct: 1991 DQDIYAVVTYQLL-GAQSGLFDINSSTGVVTV 2021
Score = 305 bits (750), Expect = 1e-81
Identities = 256/901 (28%), Positives = 414/901 (45%), Gaps = 58/901 (6%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 548 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 605
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTV--LVKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 606 FG-------------SYFDISLYEG-YGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-- 649
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 650 -PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 706
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 707 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 766
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM--TDKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 767 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 826
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 827 N-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 885
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +
Sbjct: 886 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS- 944
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 945 -GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1003
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V ED P V+ ++ TD+DVG+NA+++Y ++ + D +F + + + T
Sbjct: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITG-------GNVDGKFSVGYRDAVVRTVV 1056
Query: 538 LLDRETMSGYLLTVTARDGGVPSL--SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
LDRET + Y+L + A D G + T V ++V+DVNDN P+F Q Y A++ ED
Sbjct: 1057 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIP 1116
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVI-RTNKALDRESVATHD 654
G S+ Q+ ATDAD G GR+ Y + +F I ++G++ R + LDRE ++H
Sbjct: 1117 EGHSILQLKATDADEGEFGRVWYRI-LHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-ESDCLTFYISENSPIGTTIGEIRAHD 713
L A + P S+V V + +EDIND PVF + + E + IGT++ ++A D
Sbjct: 1176 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATD 1235
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPP 773
D G +V+Y I G + F ++ G ++T+ LDYE+ V P
Sbjct: 1236 RDSGDGGLVNYRILSGAE-GKFEIDESTGL----IITVNYLDYETKTSYMMNVSATDQAP 1290
Query: 774 LWNDVRVEILVTDVN--DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRI 831
+N + +T +N D A + ++ RV AY D +++ YR
Sbjct: 1291 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRF 1350
Query: 832 ---LSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLIT 888
S L ++ TG +T+ ++ T+ V DG ++ + +++ + ++
Sbjct: 1351 DAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLD 1410
Query: 889 E 889
E
Sbjct: 1411 E 1411
Score = 295 bits (725), Expect = 1e-78
Identities = 238/779 (30%), Positives = 370/779 (47%), Gaps = 71/779 (9%)
Query: 15 DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPED 74
D ND P F SV E A GT + + A D D+ N ++EY I + A +D
Sbjct: 2166 DINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAK----DD 2219
Query: 75 AXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSST- 133
+D F ++ +G+++ ++ ++RE VA Y V + D AS + +R S
Sbjct: 2220 TDRLVPNQ----EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
Query: 134 -ATIHVNIIDDNDNYPQFSEKTYTVSVDEDIS-VTDNPVIAKIKATDADVGANSAIRYAI 191
A + VN++D NDN PQF T ++ + T + + A D D G N + Y +
Sbjct: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 2335
Query: 192 IG----GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ G Q++ DS +G V +T+DYE+V +RA D GSP R+ + + I
Sbjct: 2336 LDLVPPGYVQLE---DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 2392
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D+NDN P F +QE+V E+VP+G I+ V A DAD G A + Y++ G+ +
Sbjct: 2393 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL------GDGES 2446
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG-GDPP---RSATATXXXXXXXXXXXX 363
I+P +G +Y LDRE + Y L A D GD R +
Sbjct: 2447 KFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCR 2506
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F Q+ + E+EP GT V+T+ ATD DE + L Y + G F + + G
Sbjct: 2507 PQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDS--G 2563
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAP--YTAS 477
L+T +PL + ++ LTV ATD G T M+ + + D N+ PVF P
Sbjct: 2564 LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILH 2621
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ P+ + V V ATD D G+N + YS N + F+I+P +G I T +
Sbjct: 2622 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGN----RDWEFFIIDPISGLIQTAQ 2677
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVF------KQQLYTANI 590
LDRE+ + Y L + A D G P +T +++++ D++DNEP+F Q +
Sbjct: 2678 RLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2737
Query: 591 MEDALVGTSVSQV-GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALD--R 647
E + GT V V GA DAD G N ++Y + EE +F + P G + + LD R
Sbjct: 2738 PEHSPRGTLVGNVTGAVDADEGPNAIVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDRER 2795
Query: 648 ESVATHDLKAVAIDGGTPPQ--SSTV---------IVHIKIEDINDSPPVFESDCLTFYI 696
E++ + +KA + TPP+ S T+ V + +EDIND PP F T +
Sbjct: 2796 EAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2855
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD 755
+ ++ +G+ + ++ A D D G N++V YSI + F D ++ TM +D
Sbjct: 2856 ATDAKVGSELIQVLALDADIGNNSLVFYSILA---IHYFRALANDSEDVGQVFTMGSMD 2911
Score = 287 bits (703), Expect = 5e-76
Identities = 247/820 (30%), Positives = 373/820 (45%), Gaps = 85/820 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ PV ++ E + + V + A+D D G NA + + I TA
Sbjct: 1839 IRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAG-- 1893
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N E A F I+ +G + LDRE++ Y + + D +P + R+
Sbjct: 1894 NRERA--------------FFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPRI 1937
Query: 131 SSTA--TIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIA---KIKATDADVGANS 185
+ + + + D+NDN+P F++ TY V E+ S P+ I A DAD +
Sbjct: 1938 ARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMEN-SPAGTPLTVLNGPILALDADQDIYA 1996
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRS--YRLVIRAQDGGSPSRSNTT 241
+ Y ++G + + F I+S +G V++ +D E L++ A+D G ++T
Sbjct: 1997 VVTYQLLGAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTA 2053
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
LLI I D NDN P F + + EN P G+S+++V A D D G+N EL Y +
Sbjct: 2054 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ 2113
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+ +T R G + +DRE Q Y+L V ATD G P S TA
Sbjct: 2114 DRFLIHLVTGVIRVG----NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIND 2169
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITG-----------GNTRG 410
F+ V + E PGT + +TA D D + +L Y I G N
Sbjct: 2170 SRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQED 2229
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG----RS---DTAMVQINITDAN 463
F++ G + V P++ + Y +T+S D+ RS A + +N+ D N
Sbjct: 2230 AFAVNINTGS--VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVN 2287
Query: 464 NYAPVFEN---APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH 520
+ P F+ Y + E A GTT++ V+A D D G+N +TY+L + V
Sbjct: 2288 DNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2347
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
D G + N+ +D E + TV A D G P + V + +VD+NDN P+
Sbjct: 2348 DSS------AGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPI 2401
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR 640
F Q Y + ED VGT + V ATDAD G I Y L E F I+P +G I
Sbjct: 2402 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG---ESKFAINPTTGDIY 2458
Query: 641 TNKALDRESVATHDLKAVAIDG----GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYI 696
+LDRE + L A+A D + + ++V V I++ D+ND P F + +
Sbjct: 2459 VLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSV 2518
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDY 756
EN P GT++ + A D DEGPN + YS++G +F ++ G LVT
Sbjct: 2519 YENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEAFHVDMDSG-----LVT-TQRPL 2571
Query: 757 ESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPV 793
+S +K+ L + A PPLW + + V DVNDN PV
Sbjct: 2572 QS-YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPV 2610
Score = 273 bits (669), Expect = 7e-72
Identities = 250/876 (28%), Positives = 390/876 (44%), Gaps = 71/876 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND++P F Q Y + E GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ------- 172
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F ID G + LD E Y + V ATDQ + L
Sbjct: 173 -PPS-------------QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK--TRPL 216
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+ A + + I D D P F Y+ ++ E + I A D D G I Y
Sbjct: 217 STLANLAIIITDVQDMDPIFINLPYSTNIYEHSP--PGTTVRIITAIDQDKGRPRGIGYT 274
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSRSN-TTQL 243
I+ GNT F++D +SG ++L LD E + S+ ++ + D +PS + TT
Sbjct: 275 IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADE--GVNAELTYTMTDKD 300
I + D+NDNAP F +S + +++E +G+++ + +Q D DE G+N+ + +
Sbjct: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
Query: 301 YTGNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV-PDHVGYAKVKITLINE 453
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F Y + L E+ GT V+T+ ATD D + RFS+ G
Sbjct: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 513
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVF 479
LI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y ++
Sbjct: 514 --LIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALR 571
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P T ++ + ATD D N QITYS+ +S A + + G I+ ++ L
Sbjct: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVISVSRPL 627
Query: 540 DRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
D E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E+ + G
Sbjct: 628 DYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAG 687
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESVATHDL 655
+V + ATD D R + + EGS F I+ SG I T LDRE+ + + L
Sbjct: 688 ATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYIL 744
Query: 656 KAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
A+DGG T I V+I + DIND+ P ++ + E +P + + + A D
Sbjct: 745 IVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVD 804
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------RKKYEL 765
PD G N + YSI+ + +SL + G + T LD E+P RK
Sbjct: 805 PDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMRKIVVS 859
Query: 766 VIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDAD 822
V PPL + V + + D+NDN P ++ + + P G +V A D D
Sbjct: 860 VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVVAIDLD 918
Query: 823 --VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
+ + YR+ G L+N ++G + + +L+
Sbjct: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
Score = 269 bits (659), Expect = 1e-70
Identities = 254/873 (29%), Positives = 397/873 (45%), Gaps = 85/873 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDV 209
F + Y+V + E+ V P+ + ATD D+GA ++ Y+ F+IDS G V
Sbjct: 132 FHNQPYSVRIPENTPV-GTPIFI-VNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIV 187
Query: 210 SLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQESVSE 268
++++ LDYE ++Y+L + A D +T L I I DV D P F + ++ E
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 247
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRET 328
+ P G ++ + A D D+G + YT+ +GN + +D SG + +G LDRE
Sbjct: 248 HSPPGTTVRIITAIDQDKGRPRGIGYTIV----SGNTNSIFALDYISGVLTLNGLLDREN 303
Query: 329 ---QAKYQLLVTATDGGD--PPRSATATXXXXXXXXXXXXXX--FMPGQYEVELAEDEPP 381
+ L V T+ D P AT T F +Y V + E
Sbjct: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQV 363
Query: 382 GTPV-VTLTATDADEDNRLH--YEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFKQ 433
G + + + D DE+ L+ +E+ GN F I TS G+ I VA PLD++
Sbjct: 364 GFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET 423
Query: 434 ERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVS 492
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 424 VDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 484 ATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTII 534
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 535 ARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP 592
Query: 613 NGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQS 668
N +I Y + F I GVI ++ LD E ++ L +A+D G PP +
Sbjct: 593 NNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLN 652
Query: 669 STVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVHY 724
STV V I++ D ND+PP F + EN G T+ + A D D G +++ Y
Sbjct: 653 STVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-Y 711
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR----- 779
S++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 712 SLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIAT 763
Query: 780 VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNNA 837
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 764 VNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-- 821
Query: 838 NLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 822 KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV----- 876
Query: 890 EMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 877 --FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 905
Score = 220 bits (538), Expect = 5e-56
Identities = 193/650 (29%), Positives = 279/650 (42%), Gaps = 49/650 (7%)
Query: 167 DNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLV 226
D PV + + A N + + + G F+++ +G V L + LD E + +
Sbjct: 45 DTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVE 104
Query: 227 IRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADE 286
D T ++ I + DVNDNAP F+ + + EN P+G I V A D D
Sbjct: 105 FSVSDHQGVI---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDL 161
Query: 287 GVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP-P 345
G + Y+ ID G V +LD ET YQL V ATD P
Sbjct: 162 GAGGSVLYSFQPPSQF------FAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
Query: 346 RSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI 403
S A F+ Y + E PPGT V +TA D D+ + Y I
Sbjct: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
Query: 404 TGGNTRGRFSITSQNG----RGLITVAQPLDFKQERRYVLTVSAT---DSGGRSD---TA 453
GNT F++ +G GL+ PL ++LTV T D SD T
Sbjct: 276 VSGNTNSIFALDYISGVLTLNGLLDRENPL---YSHGFILTVKGTELNDDRTPSDATVTT 332
Query: 454 MVQINITDANNYAPVFENAPYTASVFEDAPIGTTV-LVVSATDSDVGINAQITYSLSSEI 512
I + D N+ AP F ++ Y+ ++ E A +G + L + D D + L+S
Sbjct: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL------GLNSMF 386
Query: 513 SNEAVAHHDQQFVINPQTG------AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTD 566
V ++ F+I+P + I LD ET+ Y + A + VP
Sbjct: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
Query: 567 VEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL-DPKDR 625
V+I++++ NDN P+F Q LY ++ E+ VGTSV V ATD D G G + Y D DR
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR 505
Query: 626 EEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPP 685
F +D +G+I LD E + L +A DGG + +T V I + D+ND+ P
Sbjct: 506 ----FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVP 559
Query: 686 VFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS-FSLETRQGSD 744
F+ D + EN P T + +RA D D PN + YSI S F + +G
Sbjct: 560 TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
Query: 745 KAELVTMVDLDYESPRKKYELVIR--AASPPLWNDVRVEILVTDVNDNAP 792
+ +D + S Y V+ A +PPL + V V I V D NDN P
Sbjct: 620 VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
Score = 185 bits (450), Expect = 2e-45
Identities = 167/566 (29%), Positives = 258/566 (45%), Gaps = 60/566 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEE----ASRFFAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + + D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVS---DHQGVITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLITVAQP 428
+ E+ P GTP+ + ATD D GG+ F SQ + RG++TV +
Sbjct: 140 RIPENTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIVTVIRE 192
Query: 429 LDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E +P G
Sbjct: 193 LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPG 252
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET-- 543
TTV +++A D D G I Y++ S +N F ++ +G +T N LLDRE
Sbjct: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSI-------FALDYISGVLTLNGLLDRENPL 305
Query: 544 -MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
G++LTV D PS + TT I V+D+NDN P F Y+ I E A VG
Sbjct: 306 YSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGF 365
Query: 599 SVS---QVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALDRES 649
++ QV D ++GLN +E+ F+I P S IR LD E+
Sbjct: 366 ALPLFIQVVDKDENLGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET 423
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
V +D A + P V I + + ND+ P+F + EN +GT++ +
Sbjct: 424 VDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
Query: 710 RAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
A D D G V Y DD + FSL+ D ++ + LDYE ++ +I
Sbjct: 483 LATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTIIAR 536
Query: 770 ASPPLWNDVRVEILVTDVNDNAPVMK 795
RV I V DVNDN P +
Sbjct: 537 DGGGEETTGRVRINVLDVNDNVPTFQ 562
Score = 175 bits (425), Expect = 2e-42
Identities = 143/514 (27%), Positives = 233/514 (45%), Gaps = 27/514 (5%)
Query: 375 LAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQE 434
++ED P G+ V L A D D D L + ++G F++ G ++ + QPLD + +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDP-LVFGVSGEEASRFFAVEPDTG--VVWLRQPLDRETK 98
Query: 435 RRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSAT 494
+ + S +D G T V I + D N+ AP F N PY+ + E+ P+GT + +V+AT
Sbjct: 99 SEFTVEFSVSDHQGVI-TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
Query: 495 DSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
D D+G + YS Q F I+ G +T + LD ET Y LTV A
Sbjct: 158 DPDLGAGGSVLYSFQPP---------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
Query: 555 D-GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D LS ++ I + DV D +P+F Y+ NI E + GT+V + A D D G
Sbjct: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-VATH----DLKAVAIDGGTPPQS 668
I Y + F +D SGV+ N LDRE+ + +H +K ++ P
Sbjct: 269 RGIGYTI-VSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 327
Query: 669 STVIV--HIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDE--GPNAVVH 723
+TV +I + DIND+ P F S + I+E + +G + I+ D DE G N++
Sbjct: 328 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387
Query: 724 YSIKGGDDSNSFSLETR-QGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDVRVE 781
+ G + + T QG + + LDYE+ R ++L + P +V+
Sbjct: 388 VYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVK 447
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLIL 841
I + + NDN P+ + Y++ V A D D + ++ +
Sbjct: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFS 507
Query: 842 LNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNE 875
L++ TG + L +L+ + + T+ + DG E
Sbjct: 508 LDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE 541
Score = 89.4 bits (212), Expect = 2e-16
Identities = 82/304 (26%), Positives = 131/304 (43%), Gaps = 35/304 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEA--SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
+ V+D ND+ PVF +RE + V + ATD+D G N V Y+ L TA
Sbjct: 2599 VEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF-LKTAG 2657
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ E F ID SG + T LDRE A Y++++ A+D PV
Sbjct: 2658 NRDWE---------------FFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY 2702
Query: 129 RLSSTATIHVNIIDDNDNY---PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ + IDDN+ P Y + + S V A DAD G N+
Sbjct: 2703 ETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNA 2762
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQD--------GGSPSR 237
+ Y I GN + F + G + +++ LD E+ + +++A G SP+
Sbjct: 2763 IVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTL 2821
Query: 238 SNTTQLLIN-----IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAEL 292
L + + D+ND PRF + + V+ + +G +++V A DAD G N+ +
Sbjct: 2822 DLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLV 2881
Query: 293 TYTM 296
Y++
Sbjct: 2882 FYSI 2885
>AF312024-1|AAG48303.1| 3354|Homo sapiens cadherin related 23 protein.
Length = 3354
Score = 355 bits (872), Expect = 2e-96
Identities = 274/879 (31%), Positives = 424/879 (48%), Gaps = 59/879 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+N+LD ND+ P F+ + A V EG +G ++ + A D D G N V Y + V +
Sbjct: 878 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP-VGMPRM 936
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F I+ SG ++T LDRE++A Y + V A+D +P
Sbjct: 937 D------------------FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK--- 975
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SST+T+ ++++D ND P F Y VSV ED+ + + TD DVG N+ + Y
Sbjct: 976 SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR--VVWLNCTDNDVGLNAELSYF 1033
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR--SNTTQLLINIR 248
I GGN +FS+ V V LD E +Y L++ A D G + + T + + +
Sbjct: 1034 ITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL 1093
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F S ++ SV E++P G+SI++++A DADEG + Y + ++ N +
Sbjct: 1094 DVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIH 1153
Query: 309 ITIDPRSGWVYTSGQ-LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++ +G + + LDRE + + L+V A + P ++ F
Sbjct: 1154 VS----NGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT 1209
Query: 368 PGQY-EVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
QY + L E GT V+ + ATD D + ++Y I G G+F I GLI
Sbjct: 1210 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEI--DESTGLII 1266
Query: 425 VAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDAN--NYAPVFENAPYTASVFEDA 482
LD++ + Y++ VSATD + + IT N + A F NA Y A++ E+
Sbjct: 1267 TVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENL 1326
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
+GT ++ V A D +N QITY + S +A A F I+ TG IT L+DRE
Sbjct: 1327 ALGTEIVRVQAYSID-NLN-QITYRFDAYTSTQAKA----LFKIDAITGVITVQGLVDRE 1380
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA-NIMEDALVGTSVS 601
Y LTV A DGG P + T V I+V+D NDN P F +A +I ED VG V+
Sbjct: 1381 KGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVA 1439
Query: 602 QVGATDADVGLNGRIHYELDPKDREEGSFVI---DPASGVIRTNKALDRESVATHDLKAV 658
V A D D G NG++ + L G+F I + + G + + LDRE + + L+ V
Sbjct: 1440 TVKAWDPDAGSNGQVVFSL-ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVV 1498
Query: 659 AIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC-LTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP+ I+ + I DIND+PPV ES ++EN GT + ++RA D D G
Sbjct: 1499 ASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIG 1558
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWND 777
N+V+ Y I G+ +F ++ R + A D + +S V +P L
Sbjct: 1559 INSVLSYYITEGNKDMTFRMD-RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSAT 1617
Query: 778 VRVEILVTDVNDNAPVMKD--FQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILS 833
V + + D NDNAP+ + ++++ + D + A D D + Y I++
Sbjct: 1618 THVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEGPNGTVTYAIVA 1676
Query: 834 GNNANLILLNETTGSMTLSPQLNTNVPK-LATMEVSVTD 871
GN N ++ G +T + +L+ + T+ V+ TD
Sbjct: 1677 GNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATD 1715
Score = 350 bits (861), Expect = 4e-95
Identities = 274/832 (32%), Positives = 400/832 (48%), Gaps = 85/832 (10%)
Query: 10 QINVLDCNDHSPVFEMQ-QYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
Q+ +LD ND+ PV E Y SV E GT V+ ++ATD+DIG N+ + Y I D
Sbjct: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS 127
FR+D SG + TR A DRE+ + Y ++ D+ +P
Sbjct: 1574 M-------------------TFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT- 1613
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS+T ++V I+D+NDN P F + Y V +DE + +I I+A D D G N +
Sbjct: 1614 --LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-IQALDLDEGPNGTV 1670
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRS-YRLVIRAQDGG---SPSRSNTTQL 243
YAI+ GN F ID G ++ K LDYE Y L++ A D S ++TT +
Sbjct: 1671 TYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1730
Query: 244 LINIRDVNDNAPRF---YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKD 300
L+N+ D+NDN P F Y F+ V+E P G + A+D D G N ++ Y++ D D
Sbjct: 1731 LVNVNDINDNVPTFPRDYEGPFE--VTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGD 1787
Query: 301 YTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
G I P G V +LDRET A Y L + A D G PP S+T
Sbjct: 1788 PLGE----FVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLD 1843
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITS 416
+ + ++E+ P + V + A+DAD + RL + IT GN F I +
Sbjct: 1844 INDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINA 1903
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG-----GRSDTAMVQINITDANNYAPVFEN 471
G ++TV +PLD ++ Y LT+S D+ R D ++ I ++D N+ P+F
Sbjct: 1904 TTG--IVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1961
Query: 472 APYTASVFEDAPIGTTVLVVS----ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ Y A V E++P GT + V++ A D+D I A +TY L S F IN
Sbjct: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG--------LFDIN 2013
Query: 528 PQTGAITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
TG +T ++DRE S +L + + L+ T + I+++D NDN P F
Sbjct: 2014 SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPAT 2073
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRT-NKA 644
T +++E+ G SV QV ATD D GLNG + Y ++ ++ F+I +GVIR N
Sbjct: 2074 LTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR--FLIHLVTGVIRVGNAT 2131
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
+DRE ++ L VA D GT P S T IV I I+DINDS P F + T + E++ GT
Sbjct: 2132 IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGT 2191
Query: 705 TIGEIRAHDPDEGPNAVVH-YSIKGGDDS--------NSFSLETRQGS------DKAELV 749
I I A D D P H I DD+ ++F++ GS ELV
Sbjct: 2192 VIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELV 2251
Query: 750 TMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIF 801
++ +L R+ S P + ++ + V DVNDN P K F I +
Sbjct: 2252 ATYEVTLSVIDNASDLPERSVSVP---NAKLTVNVLDVNDNTPQFKPFGITY 2300
Score = 349 bits (857), Expect = 1e-94
Identities = 268/859 (31%), Positives = 406/859 (47%), Gaps = 51/859 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND+ P ++ Y ++ E + V T+ A D D+G+N + Y+I+
Sbjct: 766 ITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ------- 818
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P + ++ + R A L R+ ++V TD P +
Sbjct: 819 -PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK------IVVSVTDCGRPPL-KA 870
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+AT+ VN++D NDN P F + V E I + I ++ A D D G N + Y
Sbjct: 871 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVS--IYQVVAIDLDEGLNGLVSYR 928
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ G +M F I+S SG V LD E++ Y+L + A D G+P++S+T+ L I++ DV
Sbjct: 929 MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDV 988
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
ND P F+ +++ SVSE+VP + +V + D D G+NAEL+Y +T GNVD +
Sbjct: 989 NDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG----GNVDGKFS 1044
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR--SATATXXXXXXXXXXXXXXFMP 368
+ R V T LDRET A Y L++ A D G + + TAT F+
Sbjct: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRGLITVA 426
YE + ED P G ++ L ATDADE R+ Y I GN F I NG L+
Sbjct: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGL-LMRGP 1163
Query: 427 QPLDFKQERRYVLTVSA--TDSGGRSDTAMVQINITDANNYAPVFENAPYT-ASVFEDAP 483
+PLD ++ +VL V A D G + V + + D N+ APVF Y+ + E A
Sbjct: 1164 RPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1223
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
IGT+V+VV ATD D G + Y + S + +F I+ TG I T LD ET
Sbjct: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGA--------EGKFEIDESTGLIITVNYLDYET 1275
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y++ V+A D P V I++++ D F Y A I+E+ +GT + +V
Sbjct: 1276 KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRV 1335
Query: 604 GATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAID 661
A D LN +I Y D + + F ID +GVI +DRE + L VA D
Sbjct: 1336 QAYSID-NLN-QITYRFDAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADD 1393
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFE-SDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
GG P STV V+I + D ND+ P F+ + I E+ P+G + ++A DPD G N
Sbjct: 1394 GG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNG 1452
Query: 721 VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V +S+ G+ + +F + T S E+ LD E Y L + A+ +PP D
Sbjct: 1453 QVVFSLASGNIAGAFEIVTTNDS-IGEVFVARPLDREE-LDHYILQVVASDRGTPPRKKD 1510
Query: 778 VRVEILVTDVNDNAPVMKD---FQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSG 834
+++ + D+NDN PV++ + + N R D + L Y I G
Sbjct: 1511 HILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEG 1570
Query: 835 NNANLILLNETTGSMTLSP 853
N ++ +G + P
Sbjct: 1571 NKDMTFRMDRISGEIATRP 1589
Score = 338 bits (831), Expect = 2e-91
Identities = 266/889 (29%), Positives = 409/889 (46%), Gaps = 75/889 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 500
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 501 ---DD------------PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 541
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 542 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 597
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 598 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 657
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 658 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSL 713
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DG G ++ AT
Sbjct: 714 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 773
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 774 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTG 831
Query: 420 R-----GLITVAQPLDFKQERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFE 470
+ ++ P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 832 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 892 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSS 944
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 945 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1004
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESV 650
ED V + TD DVGLN + Y + +G F + V+RT LDRE+
Sbjct: 1005 SEDVPREFRVVWLNCTDNDVGLNAELSYFI-TGGNVDGKFSVGYRDAVVRTVVGLDRETT 1063
Query: 651 ATHDLKAVAIDGGT--PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A + L AID G + T V + + D+ND+ P+F + E+ P G +I +
Sbjct: 1064 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1123
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
++A D DEG V Y I G+ N+F + G + LD E + L++
Sbjct: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG---LLMRGPRPLDRER-NSSHVLIVE 1179
Query: 769 AAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVT 824
A + P+ + VRV + V D+ND APV Q ++ +G V A D D
Sbjct: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
Query: 825 D--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D + YRILSG ++E+TG + L+ M VS TD
Sbjct: 1240 DGGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATD 1287
Score = 336 bits (825), Expect = 9e-91
Identities = 274/889 (30%), Positives = 419/889 (47%), Gaps = 83/889 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASS-GTTVLTLKATDQDIGKNAEVEYTIELVT 66
H + ++D ND++P+F+ YE + EG + T+++T++A D D G N V Y I V
Sbjct: 1619 HVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI--VA 1676
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDRE-KVARYTVLVKATDQASP 125
+ +N FRID G + LD E RYT++V ATDQ
Sbjct: 1677 GNIVN-----------------TFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPI 1719
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+S RL+ST T+ VN+ D NDN P F + Y E P + A D D G N
Sbjct: 1720 LSHRLTSTTTVLVNVNDINDNVPTF-PRDYE-GPFEVTEGQPGPRVWTFLAHDRDSGPNG 1777
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQL 243
+ Y+I+ G+ +F I + G + + K LD E + Y L I A+D G P S+T +
Sbjct: 1778 QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLV 1837
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D+NDN P ++SEN P+ + V A DAD G NA LT+ +T G
Sbjct: 1838 GIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT----AG 1893
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
N + I+ +G V + LDRE +Y+L ++ D + PR A
Sbjct: 1894 NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDEN 1953
Query: 364 X---XFMPGQYEVELAEDEPPGTPVVTLT----ATDADED--NRLHYEITGGNTRGRFSI 414
F Y+ E+ E+ P GTP+ L A DAD+D + Y++ G + G F I
Sbjct: 1954 DNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS-GLFDI 2012
Query: 415 TSQNGRGLITVAQPLDFKQER----RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE 470
S G++TV + +E L + A D G + TA + I I D N+ P F
Sbjct: 2013 NSST--GVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2070
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
A T + E+ P G +VL V+ATD D G+N ++ Y + EA A +F+I+ T
Sbjct: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGA--QDRFLIHLVT 2122
Query: 531 GAITT-NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
G I N +DRE Y LTV A D G LS T V I + D+ND+ P F + T +
Sbjct: 2123 GVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVS 2182
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYEL------DPKDR----EEGSFVIDPASGVI 639
++E A GT ++ + A D D LN ++ Y + D DR +E +F ++ +G +
Sbjct: 2183 VLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSV 2240
Query: 640 RTNKALDRESVATHDLKAVAIDGGTP-PQSSTVIVHIKIE----DINDSPPVFESDCLTF 694
++RE VAT+++ ID + P+ S + + K+ D+ND+ P F+ +T+
Sbjct: 2241 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2300
Query: 695 Y---ISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
Y I E + GTT+ + A DPD+G N +V Y++ LE S +++
Sbjct: 2301 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE---DSSAGKVIAN 2357
Query: 752 VDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
+DYE +RA+ SPP ++ V + + D+NDN P+ ++D
Sbjct: 2358 RTVDYEEVH-WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFED-V 2415
Query: 809 PVGP-FGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
PVG V A DAD + G+ + +N TTG + + L+
Sbjct: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2464
Score = 330 bits (811), Expect = 4e-89
Identities = 277/882 (31%), Positives = 411/882 (46%), Gaps = 62/882 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ P+F YEASV E G ++L LKATD D G+ V Y I L
Sbjct: 1090 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI-------L 1142
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRAS-LDREKVARYTVLVKATDQASPVSDR 129
+ FRI +G L+ LDRE+ + + ++V+A +
Sbjct: 1143 HGNHGNN------------FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL---GP 1187
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYT-VSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ S+ + V + D ND P F+++ Y+ + + E + + ++ ++ATD D G +
Sbjct: 1188 MRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIV--VQATDRDSGDGGLVN 1245
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y I+ G + +F ID +G + V LDYE SY + + A D P + I +
Sbjct: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLL 1304
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
+ D A +F + ++ ++ EN+ +G IVRVQAY D +N ++TY D +
Sbjct: 1305 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN-LN-QITYRF-DAYTSTQAKAL 1361
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
ID +G + G +DRE Y L V A DGG S
Sbjct: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFT 1421
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR-GLITV 425
V + ED P G V T+ A D D + ++ + + GN G F I + N G + V
Sbjct: 1422 SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFV 1481
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENA-PYTASVFEDA 482
A+PLD ++ Y+L V A+D G R ++Q+ I D N+ PV E+ Y SV E+
Sbjct: 1482 ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1541
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL-DR 541
GT V+ V ATD D+GIN+ ++Y ++ + D F ++ +G I T DR
Sbjct: 1542 GGGTAVVQVRATDRDIGINSVLSYYITE-------GNKDMTFRMDRISGEIATRPAPPDR 1594
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA-LVGTSV 600
E S Y L T D G P+LS TT V +++VD NDN P+F+Q Y + E + TS+
Sbjct: 1595 ERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSL 1654
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE-SVATHDLKAVA 659
+ A D D G NG + Y + +F ID GVI K LD E S + L A
Sbjct: 1655 ITIQALDLDEGPNGTVTYAI-VAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTA 1713
Query: 660 IDGG---TPPQSSTVIVHIKIEDINDSPPVFESDCL-TFYISENSPIGTTIGEIRAHDPD 715
D + +ST V + + DIND+ P F D F ++E P G + AHD D
Sbjct: 1714 TDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRD 1772
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---P 772
GPN V YSI GD F + +G + V+LD E+ Y L I A P
Sbjct: 1773 SGPNGQVEYSIMDGDPLGEFVISPVEGVLRVR--KDVELDRETIAF-YNLTICARDRGMP 1829
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDAD--VTDKLQY 829
PL + + V I V D+NDN PV+ + + ++ PV F V A DAD +L +
Sbjct: 1830 PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENS-PVSSFVAHVLASDADSGCNARLTF 1888
Query: 830 RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
I +GN +N TTG +T++ L+ + +SV D
Sbjct: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
Score = 327 bits (803), Expect = 4e-88
Identities = 273/868 (31%), Positives = 416/868 (47%), Gaps = 76/868 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +L+ D + F YEA++ E + GT ++ ++A Y+I D L
Sbjct: 1301 ITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQA------------YSI-----DNL 1343
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N + + +F+ID +G + + +DREK YT+ V A D P ++
Sbjct: 1344 N-QITYRFDAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGP---KV 1398
Query: 131 SSTATIHVNIIDDNDNYPQFS-EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
ST +++ ++D+NDN P+F VS+ ED V +A +KA D D G+N + +
Sbjct: 1399 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQR--VATVKAWDPDAGSNGQVVF 1456
Query: 190 AIIGGNTQMQFSI----DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
++ GN F I DS+ G+V + + LD E++ Y L + A D G+P R L +
Sbjct: 1457 SLASGNIAGAFEIVTTNDSI-GEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQV 1515
Query: 246 NIRDVNDNAPRFYTSL-FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
I D+NDN P + + SV+ENV G ++V+V+A D D G+N+ L+Y +T+ GN
Sbjct: 1516 TILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE----GN 1571
Query: 305 VDLPITIDPRSGWVYTS-GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
D+ +D SG + T DRE Q+ Y L+ T D G P SAT
Sbjct: 1572 KDMTFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNA 1631
Query: 364 XXFMPGQYEVELAED-EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGR 420
F YEV L E + T ++T+ A D DE + + Y I GN F I
Sbjct: 1632 PMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH--M 1689
Query: 421 GLITVAQPLDFK-QERRYVLTVSATD-----SGGRSDTAMVQINITDANNYAPVFEN--- 471
G+IT A+ LD++ RY L V+ATD S + T V +N+ D N+ P F
Sbjct: 1690 GVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYE 1749
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
P+ V E P G V A D D G N Q+ YS+ + + + +FVI+P G
Sbjct: 1750 GPF--EVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSI---MDGDPLG----EFVISPVEG 1799
Query: 532 AITTNK--LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
+ K LDRET++ Y LT+ ARD G+P LS T V I V+D+NDN+PV
Sbjct: 1800 VLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNIT 1859
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES 649
I E++ V + V+ V A+DAD G N R+ + + +RE +F I+ +G++ N+ LDRE
Sbjct: 1860 ISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRER-AFFINATTGIVTVNRPLDRER 1918
Query: 650 VATHDLKAVAIDGGTPPQSSTV---IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
+ + L D P+ + ++ I + D ND+ P+F + ENSP GT +
Sbjct: 1919 IPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPL 1978
Query: 707 ----GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKK 762
G I A D D+ AVV Y + G S F + + G ++D + SP
Sbjct: 1979 TVLNGPILALDADQDIYAVVTYQLLGAQ-SGLFDINSSTGVVTVRSGVIIDREAFSP-PI 2036
Query: 763 YELVIRAASPPLWNDV-RVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
EL++ A L N + I + D NDN P + + ++C P +V A D
Sbjct: 2037 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
Query: 822 D--VTDKLQYRILSGNNANLILLNETTG 847
D + +L YRI +G + L++ TG
Sbjct: 2097 DSGLNGELVYRIEAGAQ-DRFLIHLVTG 2123
Score = 318 bits (780), Expect = 2e-85
Identities = 267/872 (30%), Positives = 418/872 (47%), Gaps = 77/872 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEA-SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+ V D ND +PVF QQY +RE A GT+V+ ++ATD+D G V Y I
Sbjct: 1196 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI------- 1248
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ F ID +G ++T LD E Y + V ATDQA P +
Sbjct: 1249 -------------LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG 1295
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S +++ ++++ D QFS +Y ++ E++++ I +++A D R+
Sbjct: 1296 FCS---VYITLLNELDEAVQFSNASYEAAILENLALGTE--IVRVQAYSIDNLNQITYRF 1350
Query: 190 -AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
A + F ID+++G +++ +D E+ Y L + A DGG P +T ++ I +
Sbjct: 1351 DAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVL 1409
Query: 249 DVNDNAPRF-YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D NDN+PRF +TS S+ E+ P+G + V+A+D D G N ++ +++ + G ++
Sbjct: 1410 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1469
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF- 366
+T + G V+ + LDRE Y L V A+D G PPR
Sbjct: 1470 -VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIE 1528
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLIT 424
P Y V + E+ GT VV + ATD D ++ L Y IT GN F + +G + T
Sbjct: 1529 SPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMTFRMDRISGE-IAT 1587
Query: 425 VAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
P D +++ Y L + D G S T V + I D N+ AP+F+ P+ + ++
Sbjct: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ-PHYEVLLDEG 1646
Query: 483 P--IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
P + T+++ + A D D G N +TY++ ++ V F I+ G IT K LD
Sbjct: 1647 PDTLNTSLITIQALDLDEGPNGTVTYAI---VAGNIV----NTFRIDRHMGVITAAKELD 1699
Query: 541 RETMSG-YLLTVTARDGGVPSLS----DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
E G Y L VTA D P LS TT V ++V D+NDN P F + + +
Sbjct: 1700 YEISHGRYTLIVTATDQ-CPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQ 1758
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNK--ALDRESVATH 653
G V A D D G NG++ Y + D G FVI P GV+R K LDRE++A +
Sbjct: 1759 PGPRVWTFLAHDRDSGPNGQVEYSIMDGD-PLGEFVISPVEGVLRVRKDVELDRETIAFY 1817
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
+L A D G PP SST++V I++ DIND+ PV + + ISENSP+ + + + A D
Sbjct: 1818 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1877
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM-VDLDYESPRKKYELVIRAASP 772
D G NA + ++I G+ +F + G +VT+ LD E +Y+L I
Sbjct: 1878 ADSGCNARLTFNITAGNRERAFFINATTG-----IVTVNRPLDRER-IPEYKLTISVKDN 1931
Query: 773 PLWNDVR------VEILVTDVNDNAPVM--KDFQI-IFNNYKDCFPV----GPFGRVPAY 819
P + + I ++D NDN P+ +Q + N P+ GP + A
Sbjct: 1932 PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA- 1990
Query: 820 DADVTDKLQYRILSGNNANLILLNETTGSMTL 851
D D+ + Y++L G + L +N +TG +T+
Sbjct: 1991 DQDIYAVVTYQLL-GAQSGLFDINSSTGVVTV 2021
Score = 305 bits (750), Expect = 1e-81
Identities = 256/901 (28%), Positives = 414/901 (45%), Gaps = 58/901 (6%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 548 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 605
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTV--LVKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 606 FG-------------SYFDISLYEG-YGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-- 649
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 650 -PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 706
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 707 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 766
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM--TDKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 767 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 826
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 827 N-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 885
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +
Sbjct: 886 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS- 944
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 945 -GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1003
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V ED P V+ ++ TD+DVG+NA+++Y ++ + D +F + + + T
Sbjct: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITG-------GNVDGKFSVGYRDAVVRTVV 1056
Query: 538 LLDRETMSGYLLTVTARDGGVPSL--SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
LDRET + Y+L + A D G + T V ++V+DVNDN P+F Q Y A++ ED
Sbjct: 1057 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIP 1116
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVI-RTNKALDRESVATHD 654
G S+ Q+ ATDAD G GR+ Y + +F I ++G++ R + LDRE ++H
Sbjct: 1117 EGHSILQLKATDADEGEFGRVWYRI-LHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-ESDCLTFYISENSPIGTTIGEIRAHD 713
L A + P S+V V + +EDIND PVF + + E + IGT++ ++A D
Sbjct: 1176 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATD 1235
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPP 773
D G +V+Y I G + F ++ G ++T+ LDYE+ V P
Sbjct: 1236 RDSGDGGLVNYRILSGAE-GKFEIDESTGL----IITVNYLDYETKTSYMMNVSATDQAP 1290
Query: 774 LWNDVRVEILVTDVN--DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRI 831
+N + +T +N D A + ++ RV AY D +++ YR
Sbjct: 1291 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRF 1350
Query: 832 ---LSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLIT 888
S L ++ TG +T+ ++ T+ V DG ++ + +++ + ++
Sbjct: 1351 DAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLD 1410
Query: 889 E 889
E
Sbjct: 1411 E 1411
Score = 295 bits (725), Expect = 1e-78
Identities = 238/779 (30%), Positives = 370/779 (47%), Gaps = 71/779 (9%)
Query: 15 DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPED 74
D ND P F SV E A GT + + A D D+ N ++EY I + A +D
Sbjct: 2166 DINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAK----DD 2219
Query: 75 AXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSST- 133
+D F ++ +G+++ ++ ++RE VA Y V + D AS + +R S
Sbjct: 2220 TDRLVPNQ----EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
Query: 134 -ATIHVNIIDDNDNYPQFSEKTYTVSVDEDIS-VTDNPVIAKIKATDADVGANSAIRYAI 191
A + VN++D NDN PQF T ++ + T + + A D D G N + Y +
Sbjct: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 2335
Query: 192 IG----GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ G Q++ DS +G V +T+DYE+V +RA D GSP R+ + + I
Sbjct: 2336 LDLVPPGYVQLE---DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 2392
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
D+NDN P F +QE+V E+VP+G I+ V A DAD G A + Y++ G+ +
Sbjct: 2393 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL------GDGES 2446
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG-GDPP---RSATATXXXXXXXXXXXX 363
I+P +G +Y LDRE + Y L A D GD R +
Sbjct: 2447 KFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCR 2506
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F Q+ + E+EP GT V+T+ ATD DE + L Y + G F + + G
Sbjct: 2507 PQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDS--G 2563
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAP--YTAS 477
L+T +PL + ++ LTV ATD G T M+ + + D N+ PVF P
Sbjct: 2564 LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILH 2621
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ P+ + V V ATD D G+N + YS N + F+I+P +G I T +
Sbjct: 2622 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGN----RDWEFFIIDPISGLIQTAQ 2677
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVF------KQQLYTANI 590
LDRE+ + Y L + A D G P +T +++++ D++DNEP+F Q +
Sbjct: 2678 RLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2737
Query: 591 MEDALVGTSVSQV-GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALD--R 647
E + GT V V GA DAD G N ++Y + EE +F + P G + + LD R
Sbjct: 2738 PEHSPRGTLVGNVTGAVDADEGPNAIVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDRER 2795
Query: 648 ESVATHDLKAVAIDGGTPPQ--SSTV---------IVHIKIEDINDSPPVFESDCLTFYI 696
E++ + +KA + TPP+ S T+ V + +EDIND PP F T +
Sbjct: 2796 EAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2855
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD 755
+ ++ +G+ + ++ A D D G N++V YSI + F D ++ TM +D
Sbjct: 2856 ATDAKVGSELIQVLALDADIGNNSLVFYSILA---IHYFRALANDSEDVGQVFTMGSMD 2911
Score = 287 bits (703), Expect = 5e-76
Identities = 247/820 (30%), Positives = 373/820 (45%), Gaps = 85/820 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ PV ++ E + + V + A+D D G NA + + I TA
Sbjct: 1839 IRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAG-- 1893
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N E A F I+ +G + LDRE++ Y + + D +P + R+
Sbjct: 1894 NRERA--------------FFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPRI 1937
Query: 131 SSTA--TIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIA---KIKATDADVGANS 185
+ + + + D+NDN+P F++ TY V E+ S P+ I A DAD +
Sbjct: 1938 ARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMEN-SPAGTPLTVLNGPILALDADQDIYA 1996
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRS--YRLVIRAQDGGSPSRSNTT 241
+ Y ++G + + F I+S +G V++ +D E L++ A+D G ++T
Sbjct: 1997 VVTYQLLGAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTA 2053
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
LLI I D NDN P F + + EN P G+S+++V A D D G+N EL Y +
Sbjct: 2054 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ 2113
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+ +T R G + +DRE Q Y+L V ATD G P S TA
Sbjct: 2114 DRFLIHLVTGVIRVG----NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIND 2169
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITG-----------GNTRG 410
F+ V + E PGT + +TA D D + +L Y I G N
Sbjct: 2170 SRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQED 2229
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG----RS---DTAMVQINITDAN 463
F++ G + V P++ + Y +T+S D+ RS A + +N+ D N
Sbjct: 2230 AFAVNINTGS--VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVN 2287
Query: 464 NYAPVFEN---APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH 520
+ P F+ Y + E A GTT++ V+A D D G+N +TY+L + V
Sbjct: 2288 DNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2347
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
D G + N+ +D E + TV A D G P + V + +VD+NDN P+
Sbjct: 2348 DSS------AGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPI 2401
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR 640
F Q Y + ED VGT + V ATDAD G I Y L E F I+P +G I
Sbjct: 2402 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG---ESKFAINPTTGDIY 2458
Query: 641 TNKALDRESVATHDLKAVAIDG----GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYI 696
+LDRE + L A+A D + + ++V V I++ D+ND P F + +
Sbjct: 2459 VLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSV 2518
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDY 756
EN P GT++ + A D DEGPN + YS++G +F ++ G LVT
Sbjct: 2519 YENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEAFHVDMDSG-----LVT-TQRPL 2571
Query: 757 ESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPV 793
+S +K+ L + A PPLW + + V DVNDN PV
Sbjct: 2572 QS-YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPV 2610
Score = 273 bits (669), Expect = 7e-72
Identities = 250/876 (28%), Positives = 390/876 (44%), Gaps = 71/876 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND++P F Q Y + E GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ------- 172
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F ID G + LD E Y + V ATDQ + L
Sbjct: 173 -PPS-------------QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK--TRPL 216
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+ A + + I D D P F Y+ ++ E + I A D D G I Y
Sbjct: 217 STLANLAIIITDVQDMDPIFINLPYSTNIYEHSP--PGTTVRIITAIDQDKGRPRGIGYT 274
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSRSN-TTQL 243
I+ GNT F++D +SG ++L LD E + S+ ++ + D +PS + TT
Sbjct: 275 IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADE--GVNAELTYTMTDKD 300
I + D+NDNAP F +S + +++E +G+++ + +Q D DE G+N+ + +
Sbjct: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
Query: 301 YTGNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV-PDHVGYAKVKITLINE 453
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F Y + L E+ GT V+T+ ATD D + RFS+ G
Sbjct: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 513
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVF 479
LI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y ++
Sbjct: 514 --LIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALR 571
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P T ++ + ATD D N QITYS+ +S A + + G I+ ++ L
Sbjct: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVISVSRPL 627
Query: 540 DRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
D E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E+ + G
Sbjct: 628 DYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAG 687
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESVATHDL 655
+V + ATD D R + + EGS F I+ SG I T LDRE+ + + L
Sbjct: 688 ATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYIL 744
Query: 656 KAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
A+DGG T I V+I + DIND+ P ++ + E +P + + + A D
Sbjct: 745 IVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVD 804
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------RKKYEL 765
PD G N + YSI+ + +SL + G + T LD E+P RK
Sbjct: 805 PDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMRKIVVS 859
Query: 766 VIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDAD 822
V PPL + V + + D+NDN P ++ + + P G +V A D D
Sbjct: 860 VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVVAIDLD 918
Query: 823 --VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
+ + YR+ G L+N ++G + + +L+
Sbjct: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
Score = 269 bits (659), Expect = 1e-70
Identities = 254/873 (29%), Positives = 397/873 (45%), Gaps = 85/873 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDV 209
F + Y+V + E+ V P+ + ATD D+GA ++ Y+ F+IDS G V
Sbjct: 132 FHNQPYSVRIPENTPV-GTPIFI-VNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIV 187
Query: 210 SLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQESVSE 268
++++ LDYE ++Y+L + A D +T L I I DV D P F + ++ E
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 247
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRET 328
+ P G ++ + A D D+G + YT+ +GN + +D SG + +G LDRE
Sbjct: 248 HSPPGTTVRIITAIDQDKGRPRGIGYTIV----SGNTNSIFALDYISGVLTLNGLLDREN 303
Query: 329 ---QAKYQLLVTATDGGD--PPRSATATXXXXXXXXXXXXXX--FMPGQYEVELAEDEPP 381
+ L V T+ D P AT T F +Y V + E
Sbjct: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQV 363
Query: 382 GTPV-VTLTATDADEDNRLH--YEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFKQ 433
G + + + D DE+ L+ +E+ GN F I TS G+ I VA PLD++
Sbjct: 364 GFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET 423
Query: 434 ERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVS 492
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 424 VDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 484 ATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTII 534
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 535 ARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP 592
Query: 613 NGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQS 668
N +I Y + F I GVI ++ LD E ++ L +A+D G PP +
Sbjct: 593 NNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLN 652
Query: 669 STVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVHY 724
STV V I++ D ND+PP F + EN G T+ + A D D G +++ Y
Sbjct: 653 STVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-Y 711
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR----- 779
S++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 712 SLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIAT 763
Query: 780 VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNNA 837
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 764 VNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-- 821
Query: 838 NLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 822 KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV----- 876
Query: 890 EMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 877 --FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 905
Score = 220 bits (538), Expect = 5e-56
Identities = 193/650 (29%), Positives = 279/650 (42%), Gaps = 49/650 (7%)
Query: 167 DNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLV 226
D PV + + A N + + + G F+++ +G V L + LD E + +
Sbjct: 45 DTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVE 104
Query: 227 IRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADE 286
D T ++ I + DVNDNAP F+ + + EN P+G I V A D D
Sbjct: 105 FSVSDHQGVI---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDL 161
Query: 287 GVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP-P 345
G + Y+ ID G V +LD ET YQL V ATD P
Sbjct: 162 GAGGSVLYSFQPPSQF------FAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
Query: 346 RSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI 403
S A F+ Y + E PPGT V +TA D D+ + Y I
Sbjct: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
Query: 404 TGGNTRGRFSITSQNG----RGLITVAQPLDFKQERRYVLTVSAT---DSGGRSD---TA 453
GNT F++ +G GL+ PL ++LTV T D SD T
Sbjct: 276 VSGNTNSIFALDYISGVLTLNGLLDRENPL---YSHGFILTVKGTELNDDRTPSDATVTT 332
Query: 454 MVQINITDANNYAPVFENAPYTASVFEDAPIGTTV-LVVSATDSDVGINAQITYSLSSEI 512
I + D N+ AP F ++ Y+ ++ E A +G + L + D D + L+S
Sbjct: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL------GLNSMF 386
Query: 513 SNEAVAHHDQQFVINPQTG------AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTD 566
V ++ F+I+P + I LD ET+ Y + A + VP
Sbjct: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
Query: 567 VEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL-DPKDR 625
V+I++++ NDN P+F Q LY ++ E+ VGTSV V ATD D G G + Y D DR
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR 505
Query: 626 EEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPP 685
F +D +G+I LD E + L +A DGG + +T V I + D+ND+ P
Sbjct: 506 ----FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVP 559
Query: 686 VFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS-FSLETRQGSD 744
F+ D + EN P T + +RA D D PN + YSI S F + +G
Sbjct: 560 TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
Query: 745 KAELVTMVDLDYESPRKKYELVIR--AASPPLWNDVRVEILVTDVNDNAP 792
+ +D + S Y V+ A +PPL + V V I V D NDN P
Sbjct: 620 VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
Score = 185 bits (450), Expect = 2e-45
Identities = 167/566 (29%), Positives = 258/566 (45%), Gaps = 60/566 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEE----ASRFFAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + + D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVS---DHQGVITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLITVAQP 428
+ E+ P GTP+ + ATD D GG+ F SQ + RG++TV +
Sbjct: 140 RIPENTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIVTVIRE 192
Query: 429 LDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E +P G
Sbjct: 193 LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPG 252
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET-- 543
TTV +++A D D G I Y++ S +N F ++ +G +T N LLDRE
Sbjct: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSI-------FALDYISGVLTLNGLLDRENPL 305
Query: 544 -MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
G++LTV D PS + TT I V+D+NDN P F Y+ I E A VG
Sbjct: 306 YSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGF 365
Query: 599 SVS---QVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALDRES 649
++ QV D ++GLN +E+ F+I P S IR LD E+
Sbjct: 366 ALPLFIQVVDKDENLGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET 423
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
V +D A + P V I + + ND+ P+F + EN +GT++ +
Sbjct: 424 VDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
Query: 710 RAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
A D D G V Y DD + FSL+ D ++ + LDYE ++ +I
Sbjct: 483 LATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTIIAR 536
Query: 770 ASPPLWNDVRVEILVTDVNDNAPVMK 795
RV I V DVNDN P +
Sbjct: 537 DGGGEETTGRVRINVLDVNDNVPTFQ 562
Score = 175 bits (425), Expect = 2e-42
Identities = 143/514 (27%), Positives = 233/514 (45%), Gaps = 27/514 (5%)
Query: 375 LAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQE 434
++ED P G+ V L A D D D L + ++G F++ G ++ + QPLD + +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDP-LVFGVSGEEASRFFAVEPDTG--VVWLRQPLDRETK 98
Query: 435 RRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSAT 494
+ + S +D G T V I + D N+ AP F N PY+ + E+ P+GT + +V+AT
Sbjct: 99 SEFTVEFSVSDHQGVI-TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
Query: 495 DSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
D D+G + YS Q F I+ G +T + LD ET Y LTV A
Sbjct: 158 DPDLGAGGSVLYSFQPP---------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
Query: 555 D-GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D LS ++ I + DV D +P+F Y+ NI E + GT+V + A D D G
Sbjct: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-VATH----DLKAVAIDGGTPPQS 668
I Y + F +D SGV+ N LDRE+ + +H +K ++ P
Sbjct: 269 RGIGYTI-VSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 327
Query: 669 STVIV--HIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDE--GPNAVVH 723
+TV +I + DIND+ P F S + I+E + +G + I+ D DE G N++
Sbjct: 328 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387
Query: 724 YSIKGGDDSNSFSLETR-QGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDVRVE 781
+ G + + T QG + + LDYE+ R ++L + P +V+
Sbjct: 388 VYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVK 447
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLIL 841
I + + NDN P+ + Y++ V A D D + ++ +
Sbjct: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFS 507
Query: 842 LNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNE 875
L++ TG + L +L+ + + T+ + DG E
Sbjct: 508 LDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE 541
Score = 89.4 bits (212), Expect = 2e-16
Identities = 82/304 (26%), Positives = 131/304 (43%), Gaps = 35/304 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEA--SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
+ V+D ND+ PVF +RE + V + ATD+D G N V Y+ L TA
Sbjct: 2599 VEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF-LKTAG 2657
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ E F ID SG + T LDRE A Y++++ A+D PV
Sbjct: 2658 NRDWE---------------FFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY 2702
Query: 129 RLSSTATIHVNIIDDNDNY---PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ + IDDN+ P Y + + S V A DAD G N+
Sbjct: 2703 ETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNA 2762
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQD--------GGSPSR 237
+ Y I GN + F + G + +++ LD E+ + +++A G SP+
Sbjct: 2763 IVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTL 2821
Query: 238 SNTTQLLIN-----IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAEL 292
L + + D+ND PRF + + V+ + +G +++V A DAD G N+ +
Sbjct: 2822 DLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLV 2881
Query: 293 TYTM 296
Y++
Sbjct: 2882 FYSI 2885
>AY354497-1|AAR10443.1| 2916|Homo sapiens cadherin protein protein.
Length = 2916
Score = 352 bits (866), Expect = 9e-96
Identities = 267/881 (30%), Positives = 420/881 (47%), Gaps = 57/881 (6%)
Query: 1 MSVPFCIHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIG-KNAEVE 59
+S+ + I+V D NDHSP F+ + SV E GT V A D D N+ ++
Sbjct: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
Y IE T NP F I G L+T + LDRE + + V A
Sbjct: 1093 YYIESHNPGT-NP-----------------FLIHPSFGTLVTVSRLDRESIPTVILTVTA 1134
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
+DQA V+DR + T + I+D ND+ P F V ED++V ++ I A D
Sbjct: 1135 SDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTV--GSLVHHITAHDP 1191
Query: 180 DVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
D G N + Y+I+ GN M F +D SG ++ LDYE + L + A D G+P+ S+
Sbjct: 1192 DEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSS 1251
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
+ L + + DVND AP F L++ SV EN G + RV+A D D GVN++L + +
Sbjct: 1252 SQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMP- 1310
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ +L I+ +G V T+ LDRE Q + L V DGG P S+T T
Sbjct: 1311 --GASFEL-FEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDE 1367
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
F+ Y++E+ E++ P V T+ A+D D N + Y I GNT F+I
Sbjct: 1368 NDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEM 1426
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYT 475
+G ++ + LD +Q + L + +D G RS +Q+ + DAN+++P F Y
Sbjct: 1427 SGE--LSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQ 1484
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
+SV EDA +GT VLV+SA D D G+N Q Y L+ E S F I+P +G + T
Sbjct: 1485 SSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASG--------AFTIDPMSGTLKT 1536
Query: 536 NKLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
+ LDRE S + + ARD + S S T +++ V DVNDN+PV +Q + + ++
Sbjct: 1537 SNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPES 1596
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ V A D D+G NG + + + F ID +G I+ + E
Sbjct: 1597 PTNQTTVIVRADDLDLGPNGTVVFSF---AETQSMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
Query: 655 LKAVAIDGGTPPQSST--VIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
L+ D G P +++T +++H++ ED+ S F ++EN GT+I ++A
Sbjct: 1653 LQLKVTDQGIPARTTTGLLVIHMEGEDVKIS---FSHHLYKGLVTENCEAGTSIVTVKAF 1709
Query: 713 DPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASP 772
PD ++ + YSI G++ SL ++ G + +D + R + +L++ A S
Sbjct: 1710 APDSIQDS-MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV---RNEVQLIVLAESS 1765
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYR 830
+V +L+ D NDN+P + + + +V A D D + ++Y
Sbjct: 1766 GHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYS 1825
Query: 831 ILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
ILSGN ++ +G +T L+ + ++ V TD
Sbjct: 1826 ILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD 1866
Score = 333 bits (819), Expect = 5e-90
Identities = 264/884 (29%), Positives = 423/884 (47%), Gaps = 68/884 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND +PVF+ YEASV+E + G V ++A D+D G N+++++ E++ +
Sbjct: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF--EIMPGASF 1314
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
++F I+ +G ++T LDRE +T+ V D P L
Sbjct: 1315 -----------------ELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFP---SL 1354
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
SST TI + D+ND+ P+F +Y + V E+ + V+ + A+D D G N A+ Y
Sbjct: 1355 SSTTTILCTVEDENDHAPEFIVSSYDIEVLEN---QEPEVVYTVLASDMDAGNNRAVEYH 1411
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
II GNT F+I+ +SG++S + LD EQ+ ++ LVI D G P RS+ L + + D
Sbjct: 1412 IIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDA 1471
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
ND++P F T +Q SV E+ +G ++ + A D DEG+N + Y +TD + +G T
Sbjct: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-EASG----AFT 1526
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGG-DPPRSATATXXXXXXXXXXXXXXFMPG 369
IDP SG + TS LDRE ++++ A D RS T
Sbjct: 1527 IDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQN 1586
Query: 370 QYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPL 429
++V L+ + P V + A D D + T+ FSI G Q
Sbjct: 1587 PFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGE---IQFQQN 1643
Query: 430 DFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTT 487
+ L + TD G R+ T ++ I++ + + F + Y V E+ GT+
Sbjct: 1644 PSSEYFPIWLQLKVTDQGIPARTTTGLLVIHM-EGEDVKISFSHHLYKGLVTENCEAGTS 1702
Query: 488 VLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN--KLLDRETMS 545
++ V A D I + YS+ S NE D + ++G +T K LD E +
Sbjct: 1703 IVTVKAFAPD-SIQDSMKYSIFS--GNE-----DGVLSLCSKSGQLTVKEPKFLDFEVRN 1754
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
L V A G + V + + D NDN P F+Q +Y A++ E L V QV A
Sbjct: 1755 EVQLIVLAESSGHRAY---CKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFA 1811
Query: 606 TDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
TD D GLNG I Y + ++EE +F ID SGVI T LD E +++ L A D G P
Sbjct: 1812 TDLDSGLNGLIEYSILSGNQEE-AFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
Query: 666 PQSSTVIVHIKIEDINDSPPVF-ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHY 724
S+T ++ +++ DIND+ P F S+ + I+E+S G + + HD D +A +
Sbjct: 1871 RLSNTTVIKVQVTDINDNAPAFLPSEAVE--ITEDSLPGVIVTHVSVHDVDLN-SAFIFS 1927
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILV 784
K + F+++ G +V + LD+E +YEL+I+ + + + + + V
Sbjct: 1928 FAKESNPGTKFAIDQNTG----VVVLVKTLDFEE-MTEYELLIQISDSVHYTEGALVVRV 1982
Query: 785 TDVNDNAPVM-KDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILL 842
DVNDN PV +DF + + PVG + A D + + + YRILS + +
Sbjct: 1983 LDVNDNPPVFSQDFYQV--TVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSI 2038
Query: 843 NETTGSM-TLSPQLNTNVPKLATMEVSVTDGVN-EIKAMMQLSV 884
+ G++ T+SP L + V +DG N +++A+ + +
Sbjct: 2039 DPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEI 2082
Score = 306 bits (751), Expect = 8e-82
Identities = 270/886 (30%), Positives = 405/886 (45%), Gaps = 79/886 (8%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
IH Q+ VLD NDHSP F Y++SVRE A GT VL L A D+D G N + EY +
Sbjct: 1462 IHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT--- 1518
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
++A F ID SG L T +LDRE +++T A D + +
Sbjct: 1519 ------DEASGA-----------FTIDPMSGTLKTSNTLDREARSQHTFSAVARDCS--I 1559
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
S+T I V + D NDN P + + V + + VI ++A D D+G N
Sbjct: 1560 QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVI--VRADDLDLGPNGT 1617
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ ++ TQ FSID +G++ + E + L ++ D G P+R+ T L+I+
Sbjct: 1618 VVFSF--AETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTDQGIPARTTTGLLVIH 1674
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D F L++ V+EN G SIV V+A+ A + + + Y++ ++GN D
Sbjct: 1675 MEG-EDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI----FSGNED 1728
Query: 307 LPITIDPRSGWVYTSGQ--LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+++ +SG + LD E + + QL+V A G A
Sbjct: 1729 GVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQDENDNSP 1785
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGL 422
F Y+ ++E + V+ + ATD D + + Y I GN F I + +G +
Sbjct: 1786 CFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSG--V 1843
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
IT LD++ Y L V ATD G S+T ++++ +TD N+ AP F + + E
Sbjct: 1844 ITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITE 1902
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
D+ G V VS D D +N+ +S + E SN +F I+ TG + K LD
Sbjct: 1903 DSLPGVIVTHVSVHDVD--LNSAFIFSFAKE-SNPGT-----KFAIDQNTGVVVLVKTLD 1954
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTD-VEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
E M+ Y L + D S+ T + + V+DVNDN PVF Q Y + E VG S
Sbjct: 1955 FEEMTEYELLIQISD----SVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRT-NKALDRESVATHDLKAV 658
V + ATD + N I Y + +E F IDP +G I T + L ++++T
Sbjct: 2011 VLTLSATDLES--NENISYRILSSSKE---FSIDPKNGTIFTISPVLLLDTISTTQFLVE 2065
Query: 659 AIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD-EG 717
A DGG P + +V I IED+N+ P F +SE++ +G+T+ D D
Sbjct: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDK------AELVTMVDLDYESPRKKYELVIRAAS 771
N V YSI G+ N+F +ET+ + LV + LD E+ +ELVI A+
Sbjct: 2126 ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASAS-HELVILASD 2184
Query: 772 ---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGP-FGRVPAYDADVTDKL 827
PPL + + I V DVNDN P + K+ P+G V A D D
Sbjct: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSY-HTHVKESTPLGSHITVVSANDRDTGSHA 2243
Query: 828 Q--YRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ Y I+SGN L E TG + L L+ T+ V +D
Sbjct: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD 2289
Score = 304 bits (746), Expect = 3e-81
Identities = 246/804 (30%), Positives = 376/804 (46%), Gaps = 65/804 (8%)
Query: 11 INVLDCNDHSPVFEM----QQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
++V D ND+ P F ++ V EG V T+ A D D G NAEV Y++
Sbjct: 827 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV---- 882
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
+ ED+ D F+ID +G + T L + Y + V ATDQ P
Sbjct: 883 ----SSEDSS-----------DHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVP- 926
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATD-ADVGANS 185
L A +++ +I + S+ + + E++ T +++ IK++D N
Sbjct: 927 --PLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPT--KIMSLIKSSDHLQQHYNG 982
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRL-VIRAQDGGSPSRSNTTQLL 244
+ ++I+ + F IDS +GD+ L K LDYE Y VI + S S+T L
Sbjct: 983 KLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLS 1042
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEG-VNAELTYTMTDKDYTG 303
I++ D ND++P F L SV ENVPIG + A D D +N+ + Y + +
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGT 1102
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG-----DPPRSATATXXXXXXX 358
N P I P G + T +LDRE+ L VTA+D RS TA
Sbjct: 1103 N---PFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVN 1159
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITS 416
P + + ED G+ V +TA D DE + ++ Y I GN F +
Sbjct: 1160 DHNPTFISFPNAH---VKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDE 1216
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
+ GL+T PLD++ + +++LTV A D G S + + + + D N+ APVF+ Y
Sbjct: 1217 SS--GLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLY 1274
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
ASV E+ G V V A D D G+N+++ + + S E F IN TG +
Sbjct: 1275 EASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFEL-------FEINSDTGEVV 1327
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T +LDRE + L V RDGG PSLS TT + +V D ND+ P F Y ++E+
Sbjct: 1328 TTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQ 1387
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
V V A+D D G N + Y + + +E F I+ SG + T +ALDRE ++
Sbjct: 1388 -EPEVVYTVLASDMDAGNNRAVEYHIIDGNTDE-CFTINEMSGELSTTRALDREQISNFT 1445
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
L + D G PP+SS + + +++ D ND P F + + E++ +GT + + A D
Sbjct: 1446 LVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDK 1505
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIRAAS-- 771
DEG N Y + + S +F+++ G+ L T LD E+ + + V R S
Sbjct: 1506 DEGLNGQTEYFLT-DEASGAFTIDPMSGT----LKTSNTLDREARSQHTFSAVARDCSIQ 1560
Query: 772 PPLWNDVRVEILVTDVNDNAPVMK 795
V +++ VTDVNDN PV++
Sbjct: 1561 GSRSTTVIIKVYVTDVNDNDPVLE 1584
Score = 302 bits (742), Expect = 1e-80
Identities = 230/753 (30%), Positives = 362/753 (48%), Gaps = 72/753 (9%)
Query: 13 VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNP 72
+ D ND+SP FE Y+ASV E V+ + ATD D G N +EY+I + N
Sbjct: 1777 IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSIL-----SGNQ 1831
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSS 132
E+A F+ID SG + T+A LD E + Y+++V+ATD+ P RLS+
Sbjct: 1832 EEA--------------FQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP---RLSN 1874
Query: 133 TATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII 192
T I V + D NDN P F + V + ED ++ + D D+ NSA ++
Sbjct: 1875 TTVIKVQVTDINDNAPAFL-PSEAVEITED--SLPGVIVTHVSVHDVDL--NSAFIFSFA 1929
Query: 193 -GGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVN 251
N +F+ID +G V LVKTLD+E++ Y L+I+ D + L++ + DVN
Sbjct: 1930 KESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEG---ALVVRVLDVN 1986
Query: 252 DNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITI 311
DN P F +Q +V E++P+GYS++ + A D + N + K++ +I
Sbjct: 1987 DNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEF--------SI 2038
Query: 312 DPRSGWVYT-SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQ 370
DP++G ++T S L +T + Q LV A+DGG+P A F
Sbjct: 2039 DPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKS 2098
Query: 371 YEVELAEDEPPGTPVVTLTATDAD---EDNRLHYEITGGNTRGRFSITSQ--------NG 419
Y + L+ED G+ +VT + D D E+ + Y I GN++ F + ++
Sbjct: 2099 YNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQ 2158
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G + + LD + + L + A+DSG S TA++ I + D N+ P F + Y
Sbjct: 2159 VGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH 2218
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E P+G+ + VVSA D D G +A+I Y++ IS H F + TG + K
Sbjct: 2219 VKESTPLGSHITVVSANDRDTGSHAEIIYNI---ISGNEKGH----FYLEENTGVLYLIK 2271
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LD E M+ + LTV A D S V +SV+D ND+ P F ++ + E+ +
Sbjct: 2272 PLDYEKMTKFTLTVQASDAEKKHFSFAV-VFVSVLDDNDHAPQFMFSSFSCIVPENLPIS 2330
Query: 598 TSVSQVGATDADVGLNGRIHYEL-DP------KDREEGSFVIDPASGVIRTNKALDRESV 650
+++ + A D D G G + Y + P + F+IDP +G I + LD E+
Sbjct: 2331 STICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENG 2390
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
+ L A D G +++++V + IE I++ P+F D F + E + IG +
Sbjct: 2391 NKYCLTVQAKDKG--DATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVE 2448
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
A D D G + V+ YS+ G S FS+ G+
Sbjct: 2449 ASDADAGIDGVILYSL--GTSSPFFSVNKTNGN 2479
Score = 288 bits (706), Expect = 2e-76
Identities = 227/755 (30%), Positives = 344/755 (45%), Gaps = 45/755 (5%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
+ V I D+NDN P F + Y SV E S N + ++ ATD D G N I Y+I+ GN
Sbjct: 1773 VAVLIQDENDNSPCFEQSIYQASVSE--SQLYNAHVIQVFATDLDSGLNGLIEYSILSGN 1830
Query: 196 TQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAP 255
+ F ID+LSG ++ LDYE SY L+++A D G P SNTT + + + D+NDNAP
Sbjct: 1831 QEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAP 1890
Query: 256 RFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRS 315
F S E +++P G + V +D D +N+ ++ + G ID +
Sbjct: 1891 AFLPSEAVEITEDSLP-GVIVTHVSVHDVD--LNSAFIFSFAKESNPGT---KFAIDQNT 1944
Query: 316 GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVEL 375
G V LD E +Y+LL+ +D A F Y+V +
Sbjct: 1945 GVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPV---FSQDFYQVTV 2001
Query: 376 AEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQER 435
E P G V+TL+ATD + + + Y I + FSI +NG + T++ L
Sbjct: 2002 PESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGT-IFTISPVLLLDTIS 2058
Query: 436 RYVLTVSATDSGGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSA 493
V A+D G A+ V+I I D NNYAP F Y S+ EDA +G+T++ S
Sbjct: 2059 TTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSN 2118
Query: 494 TDSD-VGINAQITYSLSSEISNEAVAHHDQQFVINP----QTGAITTNKLLDRETMSGYL 548
D D N + YS+ S S H + +F + Q G + LDRE + +
Sbjct: 2119 IDHDWTRENTYVEYSIISGNSQNNF-HVETKFFHSEYPYKQVGYLVLLHSLDREASASHE 2177
Query: 549 LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDA 608
L + A D G P LS T + I V+DVNDN P F Y ++ E +G+ ++ V A D
Sbjct: 2178 LVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDR 2237
Query: 609 DVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQS 668
D G + I Y + E+G F ++ +GV+ K LD E + L A D
Sbjct: 2238 DTGSHAEIIYNI-ISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHF 2295
Query: 669 STVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKG 728
S +V + + D ND P F + + EN PI +TI I A D D GP + YSI
Sbjct: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
Query: 729 --------GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASP-PLWNDVR 779
D + F ++ G A+ + LDYE+ KY L ++A +
Sbjct: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQI----LDYEN-GNKYCLTVQAKDKGDATASLV 2410
Query: 780 VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNA 837
V + + +++ P+ Q F + GRV A DAD + + Y + G ++
Sbjct: 2411 VWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSS 2468
Query: 838 NLILLNETTGSMTL---SPQLNTNVPKLATMEVSV 869
+N+T G++ L P + + + K T+E+ +
Sbjct: 2469 PFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKI 2503
Score = 258 bits (633), Expect = 2e-67
Identities = 229/822 (27%), Positives = 367/822 (44%), Gaps = 65/822 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEY---------- 60
+ V D ND+SP F V E + + A D D GKN ++ Y
Sbjct: 680 VRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFK 739
Query: 61 ---------TIELVT----ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDR 107
TI ++T A + D V + G L+ +LDR
Sbjct: 740 MNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDR 799
Query: 108 EKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSE----KTYTVSVDEDI 163
E + + V TD+ SP + +T ++V++ D NDN P F + K V V E
Sbjct: 800 EHRGHHEMTVLVTDRGSPPRN---ATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 856
Query: 164 SVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSY 223
V N ++ + A D D G N+ + Y++ ++ F ID+ +G++ L Y+ SY
Sbjct: 857 PV--NMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSY 914
Query: 224 RLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYD 283
R+ + A D G P + I + ++ ++ + EN+ + +++ D
Sbjct: 915 RMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSD 974
Query: 284 -ADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATD-G 341
+ N +L +++ D G+ + ID +G ++ S +LD ET + Y V TD
Sbjct: 975 HLQQHYNGKLHFSIVADDKDGHFE----IDSSTGDLFLSKELDYETTSHYLFRVITTDHS 1030
Query: 342 GDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE---DNR 398
+ S+T F + + E+ P GT V A D D ++R
Sbjct: 1031 KNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSR 1090
Query: 399 LHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATD-----SGGRSDTA 453
+ Y I N + + L+TV++ LD + +LTV+A+D + R +
Sbjct: 1091 IQYYIESHNPGTNPFLIHPSFGTLVTVSR-LDRESIPTVILTVTASDQAVNVTDRRLRSL 1149
Query: 454 MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEIS 513
QI I D N++ P F + P A V ED +G+ V ++A D D G N ++TYS+ S
Sbjct: 1150 TAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILS--G 1206
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
NE + F+++ +G +TT LD E + ++LTV A D G P+LS + + ++V+D
Sbjct: 1207 NE-----NMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLD 1261
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVID 633
VND PVFKQ LY A++ E+ G V++V A D D G+N ++ +E+ P E F I+
Sbjct: 1262 VNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFE-LFEIN 1320
Query: 634 PASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+G + T LDRE L+ + DGG P SST + +ED ND P F
Sbjct: 1321 SDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYD 1380
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVD 753
+ EN + + A D D G N V Y I G+ F++ G EL T
Sbjct: 1381 IEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSG----ELSTTRA 1435
Query: 754 LDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAP 792
LD E + LVI + PP + + +++ V D ND++P
Sbjct: 1436 LDREQ-ISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSP 1476
Score = 208 bits (507), Expect = 3e-52
Identities = 172/568 (30%), Positives = 259/568 (45%), Gaps = 34/568 (5%)
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF---MPG-QYEVELAEDE 379
LDRE + +++ V TD G PPR+AT F +PG + V++ E +
Sbjct: 797 LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 856
Query: 380 PPGTPVVTLTATDADEDNRLH--YEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
P V T+ A D DE N Y ++ ++ F I + NG T D++ Y
Sbjct: 857 PVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPS--Y 914
Query: 438 VLTVSATDSG--GRSDTAMVQINITD-ANNYAPVFENAPYTASVFEDAPIGTTVLVVSAT 494
++V ATD G A+V I + + A + +N + P L+ S+
Sbjct: 915 RMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSD 974
Query: 495 DSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
N ++ +S+ ++ D F I+ TG + +K LD ET S YL V
Sbjct: 975 HLQQHYNGKLHFSIVAD-------DKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
Query: 555 DGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG-L 612
D SLS T + I V D ND+ P F+ +L ++ E+ +GT V A D D L
Sbjct: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG---TPPQSS 669
N RI Y ++ + F+I P+ G + T LDRES+ T L A D T +
Sbjct: 1088 NSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLR 1147
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
++ I I D+ND P F S ++ E+ +G+ + I AHDPDEG N V YSI G
Sbjct: 1148 SLTAQIVILDVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSG 1206
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA--ASPPLWNDVRVEILVTDV 787
+++ +F L+ G L T LDYE + V+ +P L + + + V DV
Sbjct: 1207 NENMTFMLDESSGL----LTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
Query: 788 NDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDAD--VTDKLQYRILSGNNANLILLNE 844
ND APV K + + K+ G F RV A D D V KLQ+ I+ G + L +N
Sbjct: 1263 NDEAPVFKQ-HLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINS 1321
Query: 845 TTGSMTLSPQLNTNVPKLATMEVSVTDG 872
TG + + L+ + ++ T+ V V DG
Sbjct: 1322 DTGEVVTTTILDREIQEVFTLRVLVRDG 1349
Score = 166 bits (403), Expect = 1e-39
Identities = 138/478 (28%), Positives = 219/478 (45%), Gaps = 35/478 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQD-IGKNAEVEYTIELVTAD 68
+I + D N+++P F ++ Y S+ E A G+T++T D D +N VEY+I ++ +
Sbjct: 2081 EIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSI--ISGN 2138
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ N + V G L+ SLDRE A + +++ A+D P
Sbjct: 2139 SQNNFHVETKFFHSEYPYKQV-------GYLVLLHSLDREASASHELVILASDSGCP--- 2188
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
LSSTA I + ++D NDN P FS +Y V E + + I + A D D G+++ I
Sbjct: 2189 PLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSH--ITVVSANDRDTGSHAEII 2246
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y II GN + F ++ +G + L+K LDYE++ + L ++A D + + +++
Sbjct: 2247 YNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD-AEKKHFSFAVVFVSVL 2305
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY-----TG 303
D ND+AP+F S F V EN+PI +I + A D D G ELTY++ + +
Sbjct: 2306 DDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSY 2365
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+ DL IDP +G ++ LD E KY L V A D GD +A+
Sbjct: 2366 DHDL-FLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGD--ATASLVVWVDIEGIDEFE 2422
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F QY L E + + A+DAD D + Y + G + FS+ NG
Sbjct: 2423 PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNI 2480
Query: 422 LITVAQPLDFKQ-------ERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENA 472
+ A PL Q E + + +DS S T V ++ + VF ++
Sbjct: 2481 YLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASS 2538
Score = 134 bits (324), Expect = 4e-30
Identities = 131/439 (29%), Positives = 191/439 (43%), Gaps = 28/439 (6%)
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTA 476
G G+I + PL + L VSA D GG + A V I+I FE YT
Sbjct: 325 GEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTF 384
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V+ED P + + V A + + + I Y +SS +F I+P+ G I T
Sbjct: 385 LVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISS-------GDLGGKFSIHPRLGTIRTR 436
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
K LD ET +LTV A+ G P+ S +T+V I+V+DVNDN P F + I +
Sbjct: 437 KPLDHETQPVVVLTVQAQLGSAPACS-STEVNITVMDVNDNHPAFLRTSDEIRISQTTPP 495
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
GT++ A D D G NG I Y + + G F ID A GV+ N +L L
Sbjct: 496 GTALYLARAEDRDSGRNGLIRYSI--ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLT 553
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPP-VFESDCLTFYISENSPIGTTIGEIRAHD-P 714
A D G PQ++ +++ + IE SP FE +SE+ T + + +AH
Sbjct: 554 LRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLG 613
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPP- 773
+ + + YS++ DS F + G + DYES + Y + A P
Sbjct: 614 PQRAASPLRYSLEPSVDSAMFGIRPYTG----WIYLRRQFDYES-TQTYNFRVFAWIPED 668
Query: 774 --LWN-DVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQ 828
L N V + V D NDN+P + + P G G++ A D D +L
Sbjct: 669 GFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLL 728
Query: 829 YRILSGNNANLILLNETTG 847
Y +LS + +N TG
Sbjct: 729 YFLLS--DGKFFKMNPNTG 745
Score = 98.3 bits (234), Expect = 3e-19
Identities = 111/447 (24%), Positives = 189/447 (42%), Gaps = 24/447 (5%)
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSS 132
E A V ++ +I G G + L + +++V A D ++ +++
Sbjct: 304 EAASADGEAAARYVANLAKILGE-GIIYLTLPLSHLESTTLSLMVSAQDGGG-LTAVINA 361
Query: 133 TATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII 192
TIH I +F YT V ED+ D+P I +KA + + ++ I Y I
Sbjct: 362 DVTIH--IFQTTLAPAEFERPKYTFLVYEDVP-EDSP-IGTVKAREP-LNSSEPIFYRIS 416
Query: 193 GGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVND 252
G+ +FSI G + K LD+E L ++AQ G +P+ S+T ++ I + DVND
Sbjct: 417 SGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVMDVND 475
Query: 253 NAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITID 312
N P F + + +S+ P G ++ +A D D G N + Y++ G ID
Sbjct: 476 NHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PG----VFAID 530
Query: 313 PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX-XXXFMPGQY 371
G ++ +G L Q + L + A D G P++A F Y
Sbjct: 531 RALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVY 590
Query: 372 EVELAEDEPPGTPVVTLTATDADED---NRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
+VE++E P T ++ A + L Y + F I G I + +
Sbjct: 591 QVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYT--GWIYLRRQ 648
Query: 429 LDFKQERRYVLTVSA---TDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
D++ + Y V A D ++ + V + + D N+ +P F + V E++P+
Sbjct: 649 FDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKV-EESPVP 707
Query: 486 TTVL-VVSATDSDVGINAQITYSLSSE 511
V+ ++A D D G N Q+ Y L S+
Sbjct: 708 QGVIGKITAIDMDSGKNGQLLYFLLSD 734
Score = 90.2 bits (214), Expect = 9e-17
Identities = 62/236 (26%), Positives = 101/236 (42%), Gaps = 11/236 (4%)
Query: 644 ALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT-----FYISE 698
ALDRE H++ + D G+PP+++T+ V++ + DIND+ P F CL + E
Sbjct: 796 ALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF-PQCLPGKELHVKVLE 854
Query: 699 NSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES 758
P+ + + A DPDEG NA V YS+ D S+ F ++ G + T++ DY
Sbjct: 855 GQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNG--EIRTTTILSYDYRP 912
Query: 759 PRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKD---FQIIFNNYKDCFPVGPFGR 815
+ + PPL V I V ++ +M II N K +
Sbjct: 913 SYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKS 972
Query: 816 VPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
KL + I++ + ++ +TG + LS +L+ V TD
Sbjct: 973 SDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTD 1028
Score = 80.2 bits (189), Expect = 1e-13
Identities = 82/305 (26%), Positives = 131/305 (42%), Gaps = 44/305 (14%)
Query: 2 SVPFCIHQQIN--VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
S P C ++N V+D ND+ P F E + + GT + +A D+D G+N +
Sbjct: 457 SAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIR 516
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
Y+I +P+ VF ID G L SL + T+ ++A
Sbjct: 517 YSI-------ASPQPG-------------VFAIDRALGVLFLNGSLGAGEQRELTLTLRA 556
Query: 120 TDQ-ASPVSDRLSSTATIHVNIIDDNDNYPQ--FSEKTYTVSVDEDISVTDNPVIAKIKA 176
DQ P + L T +I+ ++ P F Y V V E +S P+ ++
Sbjct: 557 EDQGVHPQAALLVLTV-----VIEKREHSPSWTFEHLVYQVEVSESLS----PMTQMLQT 607
Query: 177 TDADVG---ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRA---Q 230
+G A S +RY++ F I +G + L + DYE ++Y + A +
Sbjct: 608 QAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
Query: 231 DGGSPSRSNTTQLLINIRDVNDNAPRF-YTSLFQESVSENVPIGYSIVRVQAYDADEGVN 289
DG + S T +++ + D NDN+P F + LF + VP G I ++ A D D G N
Sbjct: 668 DGFLQNVSTT--VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDSGKN 724
Query: 290 AELTY 294
+L Y
Sbjct: 725 GQLLY 729
Score = 74.5 bits (175), Expect = 5e-12
Identities = 57/160 (35%), Positives = 78/160 (48%), Gaps = 17/160 (10%)
Query: 491 VSATDSDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET-MSGYL 548
V+A+D+D G+ I YSL +S EA Q F I+P G I ++ +DRE + Y
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEA----PQAFRIDPHDGQICVSQDIDRERDPATYD 134
Query: 549 LTVTARDGGVP----------SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
L V A+DG LS V + + DVNDN PVF Y +I ++ GT
Sbjct: 135 LLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGT 194
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
+ V ATD D G+ G + YEL P F ID +G+
Sbjct: 195 EIINVLATDQDSGIYGTVAYELIP-GNVSSLFTIDSTTGL 233
Score = 69.3 bits (162), Expect = 2e-10
Identities = 56/169 (33%), Positives = 84/169 (49%), Gaps = 16/169 (9%)
Query: 601 SQVGATDADVGLNGRIHYEL-DPKDREEG--SFVIDPASGVIRTNKALDRE-SVATHDLK 656
++V A+DAD GL G I Y L D E +F IDP G I ++ +DRE AT+DL
Sbjct: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL 136
Query: 657 AVAIDGGTPPQ----------SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
A DG S+ V + +ED+ND+ PVF IS+ + GT I
Sbjct: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG--SDKAELVTMVD 753
+ A D D G V Y + G+ S+ F++++ G S + E+++ V+
Sbjct: 197 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVN 245
Score = 69.3 bits (162), Expect = 2e-10
Identities = 43/126 (34%), Positives = 63/126 (50%), Gaps = 10/126 (7%)
Query: 90 FRIDGRSGALLTRASLDREK-VARYTVLVKATD-------QASPVSDRLSSTATIHVNII 141
FRID G + +DRE+ A Y +LV+A D + V LS+ A + V++
Sbjct: 109 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLE 168
Query: 142 DDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFS 201
D NDN+P F+ TY S+ ++ I + ATD D G + Y +I GN F+
Sbjct: 169 DVNDNHPVFNPSTYVTSISDE--TQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFT 226
Query: 202 IDSLSG 207
IDS +G
Sbjct: 227 IDSTTG 232
Score = 60.1 bits (139), Expect = 1e-07
Identities = 45/154 (29%), Positives = 63/154 (40%), Gaps = 13/154 (8%)
Query: 279 VQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQ-AKYQLLVT 337
V A DAD G+ + Y++ D + IDP G + S +DRE A Y LLV
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138
Query: 338 ATDGGDPPR----------SATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVT 387
A DG + SA A F P Y ++++ PGT ++
Sbjct: 139 AKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIIN 198
Query: 388 LTATDADED--NRLHYEITGGNTRGRFSITSQNG 419
+ ATD D + YE+ GN F+I S G
Sbjct: 199 VLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 232
Score = 59.7 bits (138), Expect = 1e-07
Identities = 44/159 (27%), Positives = 72/159 (45%), Gaps = 19/159 (11%)
Query: 173 KIKATDADVGANSAIRYAIIGG----NTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVI 227
++ A+DAD G I Y++ G F ID G + + + +D E+ +Y L++
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 228 RAQDGGSPSRSNTTQLL----------INIRDVNDNAPRFYTSLFQESVSENVPIGYSIV 277
A+DG ++ + +++ DVNDN P F S + S+S+ G I+
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
Query: 278 RVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSG 316
V A D D G+ + Y + GNV TID +G
Sbjct: 198 NVLATDQDSGIYGTVAYEL----IPGNVSSLFTIDSTTG 232
Score = 51.2 bits (117), Expect = 5e-05
Identities = 25/70 (35%), Positives = 38/70 (54%)
Query: 439 LTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
+T A GG S A V++++ D N+ PVF + Y S+ ++ GT ++ V ATD D
Sbjct: 147 MTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDS 206
Query: 499 GINAQITYSL 508
GI + Y L
Sbjct: 207 GIYGTVAYEL 216
Score = 41.5 bits (93), Expect = 0.042
Identities = 18/53 (33%), Positives = 29/53 (54%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
++++ D ND+ PVF Y S+ + GT ++ + ATDQD G V Y +
Sbjct: 164 RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL 216
>AB011536-1|BAA32464.1| 1364|Homo sapiens MEGF2 protein.
Length = 1364
Score = 343 bits (844), Expect = 4e-93
Identities = 160/392 (40%), Positives = 223/392 (56%), Gaps = 17/392 (4%)
Query: 1522 CPPYSKCVTSWDSSTCTCEAGRVGPQCVSACELGPC---GAARCVPDQTPKGYSCACEPG 1578
CPP++ C W + +CTC+ G GP CV AC L PC G+ R +P P GY+C C G
Sbjct: 2 CPPHADCRDLWQTFSCTCQPGYYGPGCVDACLLNPCQNQGSCRHLPG-APHGYTCDCVGG 60
Query: 1579 YTLTTSGCIESGKEECPGGWWGGSACGPCACDVTRGYHPHCNKENGKCHCKENHYKPEGT 1638
Y C ++CP GWWG CGPC CDV +G+ P+CNK NG+CHCKE HY+P G+
Sbjct: 61 YF--GHHCEHRMDQQCPRGWWGSPTCGPCNCDVHKGFDPNCNKTNGQCHCKEFHYRPRGS 118
Query: 1639 AECLPCQCYAAGSENSSCEAATGQCHCRPGVIGRACDACANAYAEVTPNSGCEVVYDGCP 1698
CLPC CY GS + SC +GQC CRPG +GR C++C + +AEVT SGC V+YD CP
Sbjct: 119 DSCLPCDCYPVGSTSRSCAPHSGQCPCRPGALGRQCNSCDSPFAEVTA-SGCRVLYDACP 177
Query: 1699 RSFAGGVWWPRTKFGVETITDCPPGS-----SGRATRTCDETKDVPWQDPDMFNCTTATF 1753
+S GVWWP+TKFGV CP G+ +G A R CDE + W +PD+FNCT+ F
Sbjct: 178 KSLRSGVWWPQTKFGVLATVPCPRGALGLRGAGAAVRLCDEAQG--WLEPDLFNCTSPAF 235
Query: 1754 YQLRKQLHKIETGELTMNTFVGVRVAADLSTACANTPRLYGADVVVAEGILLELMDYELR 1813
+L L +E + ++T ++A L +T + DV V +L L+ +E
Sbjct: 236 RELSLLLDGLELNKTALDTMEAKKLAQRLREVTGHTDHYFSQDVRVTARLLAHLLAFESH 295
Query: 1814 QAGLNLTHSQDKDYVRNLLKSTNTILNVEYEREWKRIRELT---GHGAELLVQKFDEYIA 1870
Q G LT +QD + NLL + + +L E W + + G+ LV+ +EY A
Sbjct: 296 QQGFGLTATQDAHFNENLLWAGSALLAPETGDLWAALGQRAPGGSPGSAGLVRHLEEYAA 355
Query: 1871 VLAESQHDTYTSPFEIVTKDVVISVDTVTSES 1902
LA + TY +P +VT ++++S+D + S
Sbjct: 356 TLARNMELTYLNPMGLVTPNIMLSIDRMEHPS 387
Score = 41.5 bits (93), Expect = 0.042
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 1321 PCYNGAECSDLWDTYICDCKEGHTGKDCADS 1351
PC A+C DLW T+ C C+ G+ G C D+
Sbjct: 1 PCPPHADCRDLWQTFSCTCQPGYYGPGCVDA 31
Score = 37.9 bits (84), Expect = 0.52
Identities = 23/83 (27%), Positives = 44/83 (53%), Gaps = 1/83 (1%)
Query: 2238 CTCNHLSTFAVLVDEVDVEFIPEPSLLESVTSYTAFSISLPLLLTSWAALCLIRGGAATV 2297
C C+ TF VL+D E + L +V ++ ++S+ L+ + A L +R + V
Sbjct: 564 CRCSRTGTFGVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNV 623
Query: 2298 SNSIHKHLIFSVFMAELLYLIAL 2320
IH ++ ++ +AELL+L+ +
Sbjct: 624 -RGIHANVAAALGVAELLFLLGI 645
>AF231022-1|AAF61928.1| 4349|Homo sapiens protocadherin Fat 2 protein.
Length = 4349
Score = 339 bits (833), Expect = 9e-92
Identities = 230/720 (31%), Positives = 349/720 (48%), Gaps = 47/720 (6%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+++ D ND++P F ++Y SV E + G V TLK D DI + + T + D
Sbjct: 2893 QVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNR-QVTCYITEGDP 2951
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
L V D +RI R +LDRE A+Y + V A+D +
Sbjct: 2952 LGQ--------FGISQVGDEWRISSRK-------TLDREHTAKYLLRVTASD------GK 2990
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ T+ + ++D NDN PQ S+ YT V ED V I K+ ATD D N+ I Y
Sbjct: 2991 FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHED--VFPGHFILKVSATDLDTDTNAQITY 3048
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
++ G +F +D +G+++ + LD E+ + LV +A DGG RS + +++ D
Sbjct: 3049 SLHGPGAH-EFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGG--RSCQADITLHVED 3105
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
VNDNAPRF+ S +V +N + + V A D D+G NA++ Y++ D + +
Sbjct: 3106 VNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPD-----SAEGHF 3160
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP-PRSATATXXXXXXXXXXXXXXFMP 368
+ID +G + L QA +L V A+D G P P S T F+
Sbjct: 3161 SIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLN 3220
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
++ V++ ED PPGT V+ L + Y + GN +GRF + ++ G++ V
Sbjct: 3221 TEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDART--GILYVNAS 3278
Query: 429 LDFKQERRYVLTV--SATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGT 486
LDF+ +Y L++ S S SD V +NITD N + P F PY+ V E+A +G
Sbjct: 3279 LDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGD 3338
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
+L VSATD D +N+ ITYSL I + H F I+P+ G + K LDRE S
Sbjct: 3339 VILTVSATDEDGPLNSDITYSL---IGGNQLGH----FTIHPKKGELQVAKALDREQASS 3391
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
Y L + A D G P L + TD+ I V DVNDN P F Q Y+ + E++ +G+ V Q+ +
Sbjct: 3392 YSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILS 3451
Query: 607 DADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
D D NG + K +F + P G + T + L R + + L+ A D G PP
Sbjct: 3452 DPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQASDSGIPP 3510
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
SS V + + + + P + + E+ G +G+I A D D P + YS+
Sbjct: 3511 LSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRD--PQDTLTYSL 3568
Score = 312 bits (767), Expect = 9e-84
Identities = 260/881 (29%), Positives = 401/881 (45%), Gaps = 58/881 (6%)
Query: 3 VPFCIHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
V FC +I + D ND+ P F+ +Y S++ S + V+ + A D D G+NA+V Y++
Sbjct: 2566 VAFCT-VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSV 2624
Query: 63 ELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQ 122
NPED V+DV I+ +G + + SL + +KA D
Sbjct: 2625 --------NPED----------LVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDG 2666
Query: 123 ASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA-DV 181
P +S + + ++ + P+FSE YT S ED+ + I +KA A D
Sbjct: 2667 GPP---HWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDL--PEGSEIGIVKAVAAQDP 2721
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
S +R N FS+D +G + + K +D+E + Y++ + A + +
Sbjct: 2722 VIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLV 2781
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ I + DVNDN P F ++ ++EN+P+G S+++V A D D G + +++Y ++ D
Sbjct: 2782 SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS-ADP 2840
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR-SATATXXXXXXXXX 360
NV ID SGW+ T +LD ET Y V A D G + S+ A
Sbjct: 2841 GSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDEN 2900
Query: 361 XXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNR-LHYEITGGNTRGRFSITSQ 417
F +Y + E+ PG V TL DAD E NR + IT G+ G+F I+
Sbjct: 2901 DNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQV 2960
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTAS 477
I+ + LD + +Y+L V+A+D G + V+I + D N+ +P YT
Sbjct: 2961 GDEWRISSRKTLDREHTAKYLLRVTASD-GKFQASVTVEIFVLDVNDNSPQCSQLLYTGK 3019
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V ED G +L VSATD D NAQITYSL ++E F ++P TG +TT
Sbjct: 3020 VHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHE--------FKLDPHTGELTTLT 3071
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LDRE + L A DGG S D+ + V DVNDN P F + ++ V
Sbjct: 3072 ALDRERKDVFNLVAKATDGG--GRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVK 3129
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T V+ V A D D G N ++ Y L D EG F ID +GVIR K L A +L
Sbjct: 3130 TPVAVVFARDPDQGANAQVVYSL--PDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTV 3187
Query: 658 VAIDGGTP-PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
A D GTP P S+ V + + + D PVF + + + E++P GT + ++
Sbjct: 3188 RASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATL---T 3244
Query: 717 GPNA-VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI---RAASP 772
P A Y + G++ F L+ R G L LD+E+ KY L I R +S
Sbjct: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGI----LYVNASLDFET-SPKYFLSIECSRKSSS 3299
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYR 830
L + V + +TDVN++ P ++ V A D D + + Y
Sbjct: 3300 SLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYS 3359
Query: 831 ILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
++ GN ++ G + ++ L+ ++++ TD
Sbjct: 3360 LIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATD 3400
Score = 298 bits (731), Expect = 2e-79
Identities = 261/888 (29%), Positives = 400/888 (45%), Gaps = 75/888 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEA-SVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ N ++P FE ++ V E T + L ATD D G N ++ Y I AD
Sbjct: 702 LSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVI----ADG 757
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N E F I+ +G L A LD E Y + V D +P +
Sbjct: 758 -NEEGC--------------FDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTP---Q 799
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SS + VN+ D NDN P+F Y +++ ED V IA++ DAD N +RY
Sbjct: 800 KSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEV--GTTIAELTTKDADSEDNGRVRY 857
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRS--NTTQLLINI 247
++ + FS+ L+G++ + LD E Y L + A+D S + T L+I +
Sbjct: 858 TLLSPTEK--FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITL 915
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY-TGNVD 306
DVNDN+P+ T + V E++P G + + A D D G E+ Y + D + T VD
Sbjct: 916 EDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVD 975
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX-- 364
L +G + +LD E +A Y L + A+DGG P T
Sbjct: 976 L------MTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHP 1029
Query: 365 -XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F ++ ++ E+ P GT V+ + A D D D L Y + G FSI G
Sbjct: 1030 PHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDT--G 1087
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+I PLD + Y LTV A D G S V I +TDAN+ P A + S+
Sbjct: 1088 MIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQ 1147
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
EDAP+GT+VL + A D D ++T++++S ++ F+I+P TG ++T + L
Sbjct: 1148 EDAPVGTSVLQLDAWDPDSSSKGKLTFNITS-------GNYMGFFMIHPVTGLLSTAQQL 1200
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME--DALVG 597
DRE ++L VT D G PSL T+ V + ++DVNDN P+F +L+ + E +
Sbjct: 1201 DRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSP 1260
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
V ++ A+D D GLNGR+ Y ++ D E +F ID +GV+ +N +KA
Sbjct: 1261 GPVYRLVASDLDEGLNGRVTYSIE--DSYEEAFSIDLVTGVVSSNSTFTAGEYNILTIKA 1318
Query: 658 VAIDGGTPPQSSTVIVHIK---IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
D G PP S++V +HI+ + P F+ +F + E P+ +G I
Sbjct: 1319 T--DSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISV--- 1373
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPL 774
EG + ++I GGD F +E GS +V LD R Y L +
Sbjct: 1374 -EGRPGLFWFNISGGDKDMDFDIEKTTGS----IVIARPLDTRR-RSNYNLTVEVTDGSR 1427
Query: 775 WNDVRVEI-LVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILS 833
+V I ++ ++N + P + + +D P RV A D D L Y I
Sbjct: 1428 TIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHG 1487
Query: 834 G---NNANLILLNETTGSMTLSPQLNT-NVPKLATMEVSVTDGVNEIK 877
+A+L L+ ++G + +L+ + P T+ V V D IK
Sbjct: 1488 SQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIK 1535
Score = 279 bits (683), Expect = 1e-73
Identities = 238/799 (29%), Positives = 368/799 (46%), Gaps = 69/799 (8%)
Query: 8 HQQINVLDCND--HSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELV 65
H ++ VLD N+ H P F ++ V+E + SGT V+ + A D D G + E++Y +
Sbjct: 1015 HVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG 1074
Query: 66 TADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASP 125
T F I+ +G + T A LDRE + Y + V A D+ S
Sbjct: 1075 TG-------------------LAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
LSS +++ + D NDN PQ S+ + S+ ED V + + ++ A D D +
Sbjct: 1116 ---PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTS--VLQLDAWDPDSSSKG 1170
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
+ + I GN F I ++G +S + LD E + L + D G PS +T+++++
Sbjct: 1171 KLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVV 1230
Query: 246 NIRDVNDNAPRFYTSLFQESVSENV-PIGYS-IVRVQAYDADEGVNAELTYTMTDKDYTG 303
I DVNDN P F LF + E + P+ + R+ A D DEG+N +TY++ D
Sbjct: 1231 GILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIED----- 1285
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLL-VTATDGGDPPRSATATXXXXXX---XX 359
+ + +ID +G V ++ T +Y +L + ATD G PP SA+
Sbjct: 1286 SYEEAFSIDLVTGVVSSNSTF---TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRP 1342
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F Y + E +P V ++ + I+GG+ F I +
Sbjct: 1343 SSIPLAFDETYYSFTVMETDPVNHMVGVISV--EGRPGLFWFNISGGDKDMDFDI--EKT 1398
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQI-NITDANNYAPVFENAPYTASV 478
G I +A+PLD ++ Y LTV TD G R+ V I I + N++ P F Y V
Sbjct: 1399 TGSIVIARPLDTRRRSNYNLTVEVTD-GSRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
+D G +L V A D D G + T S + + ++ F ++P +G + T
Sbjct: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASL------FQLDPSSGVLVTVGK 1511
Query: 539 LDRET-MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LD + S + LTV RD +P + V I V D N + P F Q Y A++ + G
Sbjct: 1512 LDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPG 1571
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T + QV A DAD G+N +HY L K EG F I+ G+I + LD+ + A H L
Sbjct: 1572 TELLQVRAMDADRGVNAEVHYSL-LKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTV 1630
Query: 658 VAIDGGTPP--QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
A D G+P +TVI+H+ D S P+F I E+ P+G+ I + A P
Sbjct: 1631 KAEDQGSPQWHDLATVIIHVYPSD--RSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPS 1688
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPL 774
E V Y ++ G+ FS+ + G + T LD+E Y+L IR ++
Sbjct: 1689 E-----VTYELREGNKDGVFSMNSYSGL----ISTQKKLDHEK-ISSYQLKIRGSNMAGA 1738
Query: 775 WNDVRVEILVTDVNDNAPV 793
+ DV V + + D NDNAP+
Sbjct: 1739 FTDVMVVVDIIDENDNAPM 1757
Score = 273 bits (670), Expect = 5e-72
Identities = 253/897 (28%), Positives = 409/897 (45%), Gaps = 70/897 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++++ D ND+ P F+ Y +++G G + + ATD+D+G N V Y
Sbjct: 2057 RVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFA------ 2110
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
ED FRID G + + D + + +Y + V A D +P
Sbjct: 2111 ---EDYTY------------FRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTP---S 2152
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
L S + V + N + P F Y V V E+I++ P++ T A + Y
Sbjct: 2153 LQSEEEVLVTV--RNKSNPLFQSPYYKVRVPENITLY-TPILH----TQARSPEGLRLIY 2205
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
I+ M F+ D +G +++ LDYE + +RA D S S T ++ + D
Sbjct: 2206 NIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVL-VED 2264
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
VNDN P F ++ S+SE +P ++++ A D D G N +++Y + + +V
Sbjct: 2265 VNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDG--SDVSKFF 2322
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
I+ +G + T +LD E Q + + V A D GDPP + F
Sbjct: 2323 QINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQP 2382
Query: 370 QYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQ 427
QYE ++E G V+ + A D D + +RL Y I GN F I S +G +I++
Sbjct: 2383 QYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSG--IISMFN 2440
Query: 428 PLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTT 487
+ Y L V A+D R+ T V IN T+AN Y+P F+ Y A + E+A +GT
Sbjct: 2441 LCKKHLDSSYNLRVGASDGVFRA-TVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTK 2499
Query: 488 VLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGY 547
V+ + A D D G I Y++ +++++E +F INP G I T + LDRE +
Sbjct: 2500 VIDLLAIDKDSGPYGTIDYTIINKLASE-------KFSINPN-GQIATLQKLDRENSTER 2551
Query: 548 LLT--VTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
++ V ARDGG T V+I + D NDN P FK YT +I + + V QV A
Sbjct: 2552 VIAIKVMARDGGGRVAFCT--VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLA 2609
Query: 606 TDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G N + Y ++P+D + I+P +GV++ +L T D A DGG P
Sbjct: 2610 YDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPP 2669
Query: 666 PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYS 725
+S V V +++ S P F TF E+ P G+ IG ++A + V++
Sbjct: 2670 HWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKA---VAAQDPVIYSL 2726
Query: 726 IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEI 782
++G ++ D + +D+ES K Y++ + A + + + V V I
Sbjct: 2727 VRGTTPESNKDGVFSLDPDTGVIKVRKPMDHES-TKLYQIDVMAHCLQNTDVVSLVSVNI 2785
Query: 783 LVTDVNDNAPVMK--DFQIIFNNYKDCFPVG-PFGRVPAYDADV--TDKLQYRILS--GN 835
V DVNDN PV + ++ + + PVG +V A D D ++ YR+ + G+
Sbjct: 2786 QVGDVNDNRPVFEADPYKAVLT---ENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGS 2842
Query: 836 NAN-LILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRL-ITEE 890
N + L ++ +G +T +L+ + V D I+ Q V++ IT+E
Sbjct: 2843 NVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
Score = 271 bits (664), Expect = 3e-71
Identities = 253/902 (28%), Positives = 409/902 (45%), Gaps = 60/902 (6%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
VF +D +G + R +D E Y + V A +D + S ++++ + D NDN P
Sbjct: 2739 VFSLDPDTGVIKVRKPMDHESTKLYQIDVMA--HCLQNTD-VVSLVSVNIQVGDVNDNRP 2795
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII---GGNTQMQFSIDSL 205
F Y + E++ V + + ++ A D D G + + Y + G N F+IDS
Sbjct: 2796 VFEADPYKAVLTENMPVGTS--VIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSE 2853
Query: 206 SGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIRDVNDNAPRFYTSLFQE 264
SG ++ ++ LD E ++Y + A D G + ++ L+ ++I D NDNAPRF + ++
Sbjct: 2854 SGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRG 2913
Query: 265 SVSENVPIGYSIVRVQAYDAD-EGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
SV EN G + ++ DAD N ++T +T+ D G + D W +S +
Sbjct: 2914 SVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDE---WRISSRK 2970
Query: 324 -LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
LDRE AKY L VTA+DG A+ T Y ++ ED PG
Sbjct: 2971 TLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPG 3027
Query: 383 TPVVTLTATDADEDN--RLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
++ ++ATD D D ++ Y + G F + G +T LD +++ + L
Sbjct: 3028 HFILKVSATDLDTDTNAQITYSLHGPGAH-EFKLDPHTGE--LTTLTALDRERKDVFNLV 3084
Query: 441 VSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD GGRS A + +++ D N+ AP F + +VF++ + T V VV A D D G
Sbjct: 3085 AKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA 3144
Query: 501 NAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP- 559
NAQ+ YSL + A H F I+ TG I K L + LTV A D G P
Sbjct: 3145 NAQVVYSLP----DSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPI 3196
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYE 619
LS V +SVV + D PVF ++ + EDA GT V Q+ AT G + Y
Sbjct: 3197 PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQL-ATLTRPGAE-KTGYR 3254
Query: 620 LDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIED 679
+ E+G F +D +G++ N +LD E+ + L + S V + I D
Sbjct: 3255 V-VSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITD 3313
Query: 680 INDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLET 739
+N+ P F D + + EN+ +G I + A D D N+ + YS+ GG+ F++
Sbjct: 3314 VNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHP 3373
Query: 740 RQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKD 796
++G EL LD E Y L +RA PPL D + I V DVNDN P +
Sbjct: 3374 KKG----ELQVAKALDREQ-ASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPP--RF 3426
Query: 797 FQIIFN-NYKDCFPVG-PFGRVPAYDADVTDK---LQYRILSGNNANLILLNETTGSMTL 851
FQ+ ++ ++ P+G ++ D D + +RI GNN + + G +
Sbjct: 3427 FQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT-PDGWLVT 3485
Query: 852 SPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTAEQFLS 910
+ L+ + +++ +D G+ + ++ + V +TE+ + L ++
Sbjct: 3486 AEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVH-VTEQSHYAPSALPL-EIFITVGED 3543
Query: 911 PLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSARRPDAEVGVA-GDPSPH 969
G + + A P++ + +++T L FS PD ++ A G P H
Sbjct: 3544 EFQGGMVGKIHATDRDPQDTLTYSLAEEET------LGRHFSVGAPDGKIIAAQGLPRGH 3597
Query: 970 YS 971
YS
Sbjct: 3598 YS 3599
Score = 259 bits (634), Expect = 1e-67
Identities = 235/862 (27%), Positives = 377/862 (43%), Gaps = 71/862 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I + D ND+SP + V E GT + L A+D D+G EV Y +
Sbjct: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVL-------- 964
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
FR+D +GAL+ LD E+ A Y + + A+D P++ R
Sbjct: 965 ------------MDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRT 1012
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ V +++N + P F+ + V E+ S + VI + A D D G + ++Y
Sbjct: 1013 LCHVEVIVLDVNENLHPPHFASFVHQGQVQEN-SPSGTQVIV-VAAQDDDSGLDGELQYF 1070
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ G FSI+ +G + + LD E Y L + A D GS S+ T++ I + D
Sbjct: 1071 LRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDA 1130
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P+ ++F S+ E+ P+G S++++ A+D D +LT+ +T +Y G
Sbjct: 1131 NDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGF----FM 1186
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQ 370
I P +G + T+ QLDRE + ++ L VT D G+P +T+ F
Sbjct: 1187 IHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKL 1246
Query: 371 YEVELAEDEPPGT--PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVA 426
+ V L E P + PV L A+D DE + R+ Y I FSI G V+
Sbjct: 1247 FNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSYEEA-FSIDLVTG----VVS 1301
Query: 427 QPLDFKQERRYVLTVSATDSGGRSDTAMVQINI-----TDANNYAPVFENAPYTASVFED 481
F +LT+ ATDSG +A V+++I ++ F+ Y+ +V E
Sbjct: 1302 SNSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET 1361
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
P+ V V+S G +++S D F I TG+I + LD
Sbjct: 1362 DPVNHMVGVISVE----GRPGLFWFNISG-------GDKDMDFDIEKTTGSIVIARPLDT 1410
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEI-SVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
S Y LTV DG S + T V I + ++N + P F + Y + +D + G +
Sbjct: 1411 RRRSNYNLTVEVTDG---SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVEL 1467
Query: 601 SQVGATDADVG--LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-VATHDLKA 657
+V A D D G L IH DP F +DP+SGV+ T LD S + H L
Sbjct: 1468 LRVQAIDQDKGKSLIYTIHGSQDP--GSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTV 1525
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
+ D P + + V V I +ED N PP F + + GT + ++RA D D G
Sbjct: 1526 MVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRG 1585
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA--ASPPLW 775
NA VHYS+ G+ F++ G ++T+ ++ + L ++A P W
Sbjct: 1586 VNAEVHYSLLKGNSEGFFNINALLG-----IITLAQKLDQANHAPHTLTVKAEDQGSPQW 1640
Query: 776 NDVRVEILVTDVND-NAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSG 834
+D+ I+ +D +AP+ + F + PVG + A ++ Y + G
Sbjct: 1641 HDLATVIIHVYPSDRSAPIFSKSE-YFVEIPESIPVG--SPILLVSAMSPSEVTYELREG 1697
Query: 835 NNANLILLNETTGSMTLSPQLN 856
N + +N +G ++ +L+
Sbjct: 1698 NKDGVFSMNSYSGLISTQKKLD 1719
Score = 254 bits (623), Expect = 3e-66
Identities = 248/879 (28%), Positives = 394/879 (44%), Gaps = 86/879 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I+V D N H P F YEASV + + GT +L ++A D D G NAEV Y+ L+ ++
Sbjct: 1543 IHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYS--LLKGNS- 1599
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F I+ G + LD+ A +T+ VKA DQ SP +
Sbjct: 1600 ----------------EGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP---QW 1640
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
AT+ +++ + + P FS+ Y V + E I V +P++ + S + Y
Sbjct: 1641 HDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPV-GSPILL------VSAMSPSEVTYE 1693
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ GN FS++S SG +S K LD+E++ SY+L IR + ++++I D
Sbjct: 1694 LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSN--MAGAFTDVMVVVDIIDE 1751
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVR--------VQAYDADEGVNAELTYTMTDKDYT 302
NDNAP F S F +SE P+ YS++ + A D+D+ N+ L Y + + +
Sbjct: 1752 NDNAPMFLKSTFVGQISEAAPL-YSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEAL 1810
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXX 360
IDP G + ++D E+ +Q V D G P A A
Sbjct: 1811 KF----FKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVN 1866
Query: 361 XXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR 420
F YEV + PG ++ + A+D ED+ ++Y I GN ++T
Sbjct: 1867 DSPPRFSEQIYEVAIVGPIHPGMELLMVRASD--EDSEVNYSIKTGNADE--AVTIHPVT 1922
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
G I+V P R+ LT+ A+D G DTA+V+I++T + + F+ Y A+V E
Sbjct: 1923 GSISVLNPAFLGLSRK--LTIRASD-GLYQDTALVKISLTQVLDKSLQFDQDVYWAAVKE 1979
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL-L 539
+ ++++ A + +N ++Y L ++ + H Q G + T +
Sbjct: 1980 NLQDRKALVILGAQGNH--LNDTLSYFL---LNGTDMFHMVQS------AGVLQTRGVAF 2028
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
DRE + L V RD P V +S+ DVNDN P FK Y I + G
Sbjct: 2029 DREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDV 2088
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+ QV ATD D+G NG + YE + F IDP G I K D +++ + LK +A
Sbjct: 2089 LFQVSATDEDLGTNGAVTYEF---AEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIA 2145
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGGTP S V + + N S P+F+S + EN + T I +A P EG
Sbjct: 2146 RDGGTPSLQSEEEVLVTVR--NKSNPLFQSPYYKVRVPENITLYTPILHTQARSP-EGLR 2202
Query: 720 AVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPL--WND 777
+ Y+I + F+ + + G L LDYES + K+ +RA L +++
Sbjct: 2203 LI--YNIVEEEPLMLFTTDFKTG----VLTVTGPLDYES-KTKHVFTVRATDTALGSFSE 2255
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPV-GPFGRVPAYDADV--TDKLQYRILSG 834
VE+LV DVNDN P + + + P P ++ A D D + Y+I+
Sbjct: 2256 ATVEVLVEDVNDNPPTFSQL-VYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVED 2314
Query: 835 NN--ANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ + +N +TG M+ +L+ + ++V D
Sbjct: 2315 GSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMD 2353
Score = 222 bits (542), Expect = 2e-56
Identities = 161/528 (30%), Positives = 262/528 (49%), Gaps = 29/528 (5%)
Query: 373 VELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLD 430
+++ E P TP+ L ATD D + +L Y I GN G F I + G L+TVA PLD
Sbjct: 722 IDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETG--LLTVAAPLD 779
Query: 431 FKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTV 488
++ Y+L V+ D G +S ++ +N+ D N+ AP F Y ++ ED +GTT+
Sbjct: 780 YEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTI 839
Query: 489 LVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYL 548
++ D+D N ++ Y+L S ++F ++P TG + LDRE+ Y+
Sbjct: 840 AELTTKDADSEDNGRVRYTLLSP---------TEKFSLHPLTGELVVTGHLDRESEPRYI 890
Query: 549 LTVTARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
L V ARD L TD+ I++ DVNDN P + + ED GT ++ + A+
Sbjct: 891 LKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDAS 950
Query: 607 DADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
D D+G G + Y L D G+F +D +G + + LD E A ++L A DGG P
Sbjct: 951 DPDLGPAGEVRYVL--MDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPL 1008
Query: 667 QSSTVI-VHIKIEDINDS--PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVH 723
T+ V + + D+N++ PP F S + ENSP GT + + A D D G + +
Sbjct: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEIL 783
Y ++ G +FS+ Q + + + +D ++ S L + S PL + V I
Sbjct: 1069 YFLRAGTGLAAFSI--NQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIE 1126
Query: 784 VTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTD--KLQYRILSGNNANLI 840
VTD NDN P M + + + ++ PVG ++ A+D D + KL + I SGN
Sbjct: 1127 VTDANDNPPQMSQ-AVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
Query: 841 LLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSVRLI 887
+++ TG ++ + QL+ +EV+V D G +K+ ++ V ++
Sbjct: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGIL 1233
Score = 187 bits (456), Expect = 4e-46
Identities = 127/374 (33%), Positives = 184/374 (49%), Gaps = 16/374 (4%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
Q FR+D R+G L ASLD E +Y + ++ + ++S LS T+ VNI D N++
Sbjct: 3261 QGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSS---SSLSDVTTVMVNITDVNEH 3317
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
PQF + Y+ V E+ V D VI + ATD D NS I Y++IGGN F+I
Sbjct: 3318 RPQFPQDPYSTRVLENALVGD--VILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKK 3375
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
G++ + K LD EQ SY L +RA D G P T + I + DVNDN PRF+ + +V
Sbjct: 3376 GELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTV 3435
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDR 326
EN PIG ++++ D D N Y+ + GN + P GW+ T+ L R
Sbjct: 3436 QENSPIGSKVLQLILSDPDSPENGP-PYSF--RITKGNNGSAFRVTP-DGWLVTAEGLSR 3491
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
Q YQL + A+D G PP S+ + +P + + + EDE G V
Sbjct: 3492 RAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVG 3551
Query: 387 TLTATDADEDNRLHYEITGGNTRGR-FSITSQNGRGLITVAQPLDFKQERRYVLTVSATD 445
+ ATD D + L Y + T GR FS+ + +G+ I AQ L Y V+ +D
Sbjct: 3552 KIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGK--IIAAQGL---PRGHYSFNVTVSD 3606
Query: 446 SGGRSDTAMVQINI 459
G + TA V + +
Sbjct: 3607 -GTFTTTAGVHVYV 3619
Score = 150 bits (363), Expect = 8e-35
Identities = 129/418 (30%), Positives = 197/418 (47%), Gaps = 32/418 (7%)
Query: 450 SDTAMVQINITDANNYAPVFENA-PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL 508
SD ++ N+Y P FE+ P + V E PI T + ++ATD D G N ++ Y +
Sbjct: 695 SDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVI 754
Query: 509 SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVE 568
+ NE + F I +TG +T LD E + Y+L VT D G P S +
Sbjct: 755 AD--GNE-----EGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLT 807
Query: 569 ISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYE-LDPKDREE 627
++V D NDN P F Y I ED VGT+++++ DAD NGR+ Y L P ++
Sbjct: 808 VNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK-- 865
Query: 628 GSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQS--STVIVHIKIEDINDSPP 685
F + P +G + LDRES + LK A D + S + I +ED+ND+ P
Sbjct: 866 --FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
Query: 686 VFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
++ + E+ P GT + + A DPD GP V Y + G +F ++ G+
Sbjct: 924 QCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGA-- 980
Query: 746 AELVTMVDLDYESPRKKYELVIRAA--SPPLWNDV--RVEILVTDVNDN--APVMKDFQI 799
L+ +LD+E R Y L + A+ PL VE++V DVN+N P F +
Sbjct: 981 --LILERELDFER-RAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASF-V 1036
Query: 800 IFNNYKDCFPVGPFGRVPAY---DADVTDKLQYRILSGNNANLILLNETTGSM-TLSP 853
++ P G V A D+ + +LQY + +G +N+ TG + TL+P
Sbjct: 1037 HQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP 1094
Score = 148 bits (359), Expect = 2e-34
Identities = 165/630 (26%), Positives = 270/630 (42%), Gaps = 45/630 (7%)
Query: 125 PVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGA 183
P+ LSS+A + + Y S KTY S ++ I + + + + DV
Sbjct: 21 PLEGILSSSAWHFTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVAN 80
Query: 184 NSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQL 243
++G ++ I + S + +L L+ E SY L+I+A + + T++
Sbjct: 81 VFKTEEYVVGNFCFLR--IRTKSSNTAL---LNREVRDSYTLIIQATEKTLELEA-LTRV 134
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
+++I D ND P F ++ ++SE++P+ I +V A DAD G NAE Y +
Sbjct: 135 VVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEM- 193
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
I P SG V +G+L+ + K++L V A D
Sbjct: 194 -----FAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEP 248
Query: 364 XXFMPGQYE--VELAEDEPPGTPVVT-LTATDADEDNRLHYEITGGNTRGRF----SITS 416
P V D GT T L ++ E+ GG+ F S
Sbjct: 249 ALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYAR 308
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQ-INITDANNYAPVFENAPYT 475
N L++V + + L++ A G + ++ ++ + + FE A Y
Sbjct: 309 SNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYR 368
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
+ E +P G+ V++V T + N Q SSE + F +N +TG ITT
Sbjct: 369 VQLSEFSPPGSRVVMVRVTPAFP--NLQYVLKPSSE---------NVGFKLNARTGLITT 417
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
KL+D + Y L + G +T V I +VD N++ P+F + Y + E+
Sbjct: 418 TKLMDFHDRAHYQLHIRTSPG-----QASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIP 472
Query: 596 VGTSVSQVGATDADVGLNGRIHYEL-DPKDREEGSFVIDPASGVIRTNKALDRESV-ATH 653
GTSV V ATD D G NG + Y + PK F IDP G+I T+K +D E + +
Sbjct: 473 PGTSVLAVTATDRDHGENGYVTYSIAGPKAL---PFSIDPYLGIISTSKPMDYELMKRIY 529
Query: 654 DLKAVAIDGGTP-PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
+ A D G+P + V + +++ ++ND+ P+FE T I ++ P+G +I + A
Sbjct: 530 TFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAI 589
Query: 713 DPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
D DE N + Y I G++ F L G
Sbjct: 590 DVDELQN--LKYEIVSGNELEYFDLNHFSG 617
Score = 128 bits (309), Expect = 3e-28
Identities = 141/567 (24%), Positives = 238/567 (41%), Gaps = 42/567 (7%)
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
L+RE + Y L++ AT+ + T F P Y V ++ED P +
Sbjct: 107 LNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPL-FSPPSYRVTISEDMPLKS 165
Query: 384 PVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
P+ +TATDAD + F+I +G ++TVA L+ ++ L V A
Sbjct: 166 PICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSG--VVTVAGKLNVTWRGKHELQVLA 223
Query: 444 TD-------SGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
D G A + +++ A P + T D+ GTT V +
Sbjct: 224 VDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPP---DSNDGTTYATVLVDAN 280
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
G + + + A + + + + ++ + E + G+ L++ AR G
Sbjct: 281 SSGAEVESVEVVGGDPGKHFKAI--KSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSG 338
Query: 557 GVPSL-SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGR 615
P S + ++ + F++ +Y + E + G+ V V T A L
Sbjct: 339 SGPYFYSQIRGFHLPPSKLSSLK--FEKAVYRVQLSEFSPPGSRVVMVRVTPAFPNLQ-- 394
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
Y L P G F ++ +G+I T K +D A + L +P Q+STV+V I
Sbjct: 395 --YVLKPSSENVG-FKLNARTGLITTTKLMDFHDRAHYQLHIRT----SPGQASTVVV-I 446
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
I D N+ P+F + EN P GT++ + A D D G N V YSI G + F
Sbjct: 447 DIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPF 505
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA--SPPLWNDVRVEIL--VTDVNDNA 791
S++ G + T +DYE ++ Y +RA+ P + V I + ++NDN
Sbjct: 506 SIDPYLGI----ISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
Query: 792 PVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
P+ ++ + +D +PVG + A D D L+Y I+SGN LN +G ++
Sbjct: 562 PMFEEVNCTGSIRQD-WPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVIS 620
Query: 851 LS-PQLNTNV--PKLATMEVSVTDGVN 874
L P +N P +++++ +DG N
Sbjct: 621 LKRPFINLTAGQPTSYSLKITASDGKN 647
Score = 128 bits (309), Expect = 3e-28
Identities = 102/326 (31%), Positives = 164/326 (50%), Gaps = 24/326 (7%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITV 425
F Y V+L+E PPG+ VV + T A + L Y + + F + ++ G LIT
Sbjct: 362 FEKAVYRVQLSEFSPPGSRVVMVRVTPAFPN--LQYVLKPSSENVGFKLNARTG--LITT 417
Query: 426 AQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
+ +DF Y L + S G++ T +V I+I D NN+AP+F + Y ++ E+ P G
Sbjct: 418 TKLMDFHDRAHYQLHIRT--SPGQASTVVV-IDIVDCNNHAPLFNRSSYDGTLDENIPPG 474
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
T+VL V+ATD D G N +TYS++ +A+ F I+P G I+T+K +D E M
Sbjct: 475 TSVLAVTATDRDHGENGYVTYSIAGP---KAL-----PFSIDPYLGIISTSKPMDYELMK 526
Query: 546 G-YLLTVTARDGGVPSLSD-TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
Y V A D G P + + + + ++NDN+P+F++ T +I +D VG S+ +
Sbjct: 527 RIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTM 586
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA---LDRESVATHDLKAVAI 660
A D D N + YE+ E F ++ SGVI + L ++ LK A
Sbjct: 587 SAIDVDELQN--LKYEI-VSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITAS 643
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPV 686
DG +T+ + + ++D + PV
Sbjct: 644 DGKNYASPTTLNITV-VKDPHFEVPV 668
Score = 107 bits (256), Expect = 7e-22
Identities = 80/279 (28%), Positives = 136/279 (48%), Gaps = 19/279 (6%)
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++Y + + + F +++ +G ++ K +D+ Y+L IR SP +++T ++I+
Sbjct: 393 LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT----SPGQASTV-VVID 447
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D N++AP F S + ++ EN+P G S++ V A D D G N +TY++ G
Sbjct: 448 IVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-----AGPKA 502
Query: 307 LPITIDPRSGWVYTSGQLDRETQAK-YQLLVTATDGGDP-PRSATATXXXXXXXXXXXXX 364
LP +IDP G + TS +D E + Y V A+D G P R +
Sbjct: 503 LPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQP 562
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
F + +D P G ++T++A D DE L YEI GN F + + G+I+
Sbjct: 563 MFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDL--NHFSGVIS 620
Query: 425 VAQP---LDFKQERRYVLTVSATDSGGRSDTAMVQINIT 460
+ +P L Q Y L ++A+D G++ + +NIT
Sbjct: 621 LKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNIT 657
Score = 105 bits (253), Expect = 2e-21
Identities = 139/579 (24%), Positives = 247/579 (42%), Gaps = 72/579 (12%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+++LD ND P+F Y ++ E + + + ATD D+G+NAE Y
Sbjct: 136 VHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFN------- 188
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSD-- 128
++F I SG + L+ ++ + V A D+ +S+
Sbjct: 189 --------------TRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGN 234
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S A + V++ P + T D + T V+ ++ A+V +
Sbjct: 235 GFGSLAALVVHVEPALRKPPAIASVVVT-PPDSNDGTTYATVLVDANSSGAEVES----- 288
Query: 189 YAIIGGNTQMQF-SIDSL--SGDVSLVKTLD---YEQVRSYRLVIRAQDGGSPSRSNTTQ 242
++GG+ F +I S S + SLV D E + + L ++A+ G P + +
Sbjct: 289 VEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIR 348
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
++ ++ +F ++++ +SE P G +V V+ A L Y + K +
Sbjct: 349 -GFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPA----FPNLQYVL--KPSS 401
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
NV ++ R+G + T+ +D +A YQL + + P A+
Sbjct: 402 ENVG--FKLNARTGLITTTKLMDFHDRAHYQLHIRTS-----PGQASTVVVIDIVDCNNH 454
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR 420
F Y+ L E+ PPGT V+ +TATD D E+ + Y I G FSI
Sbjct: 455 APLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKAL-PFSIDPY--L 511
Query: 421 GLITVAQPLDFK-QERRYVLTVSATDSGG---RSDTAMVQINITDANNYAPVFENAPYTA 476
G+I+ ++P+D++ +R Y V A+D G R + + + + N+ P+FE T
Sbjct: 512 GIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTG 571
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
S+ +D P+G +++ +SA D D N + Y + S NE + F +N +G I+
Sbjct: 572 SIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVS--GNEL-----EYFDLNHFSGVISLK 622
Query: 537 KLLDRETM---SGYLLTVTARDGGVPSLSDTTDVEISVV 572
+ T + Y L +TA DG + + T + I+VV
Sbjct: 623 RPFINLTAGQPTSYSLKITASDG--KNYASPTTLNITVV 659
Score = 93.9 bits (223), Expect = 7e-18
Identities = 76/249 (30%), Positives = 118/249 (47%), Gaps = 31/249 (12%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I+++DCN+H+P+F Y+ ++ E GT+VL + ATD+D G+N V Y+I
Sbjct: 446 IDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-------A 498
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVAR-YTVLVKATDQASPVSDR 129
P+ F ID G + T +D E + R YT V+A+D SP R
Sbjct: 499 GPKAL-------------PFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF--R 543
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+I + + + NDN P F E T S+ +D V + I + A D D N ++Y
Sbjct: 544 REKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKS--IMTMSAIDVDELQN--LKY 599
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVK---TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I+ GN F ++ SG +SL + L Q SY L I A DG + + T + +
Sbjct: 600 EIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITV- 658
Query: 247 IRDVNDNAP 255
++D + P
Sbjct: 659 VKDPHFEVP 667
Score = 62.1 bits (144), Expect = 3e-08
Identities = 44/130 (33%), Positives = 72/130 (55%), Gaps = 10/130 (7%)
Query: 103 ASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDED 162
A L+RE YT++++AT++ L + + V+I+D ND P FS +Y V++ ED
Sbjct: 105 ALLNREVRDSYTLIIQATEKTL----ELEALTRVVVHILDQNDLKPLFSPPSYRVTISED 160
Query: 163 ISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQ-FSIDSLSGDVSLVKTLDYEQVR 221
+ + +P I K+ ATDAD+G N+ YA NT+ + F+I SG V++ L+
Sbjct: 161 MPL-KSP-ICKVTATDADLGQNAEFYYAF---NTRSEMFAIHPTSGVVTVAGKLNVTWRG 215
Query: 222 SYRLVIRAQD 231
+ L + A D
Sbjct: 216 KHELQVLAVD 225
Score = 44.4 bits (100), Expect = 0.006
Identities = 66/255 (25%), Positives = 102/255 (40%), Gaps = 51/255 (20%)
Query: 1103 CELRARSFPVSSFLTF--PGLKRRHRIHLKLKFATQTTSGLLLYNGRYNERHDFLALELV 1160
C A F S++ + P + H IH LK T +LL+ NE ++L+L
Sbjct: 3771 CNGTATRFSGQSYVRYRAPAARNWH-IHFYLK--TLQPQAILLFT---NETAS-VSLKLA 3823
Query: 1161 SSEAGRGGGPGLRFSFSLGGGKSEITVEGNVGDGSWHTVEIEYFNRTITMILDDCDKVLS 1220
S G P L + LGG ++ + +V D WH++ +E + +I +++D
Sbjct: 3824 S------GVPQLEYH-CLGGFYGNLSSQRHVNDHEWHSILVEEMDASIRLMVDSMGN--- 3873
Query: 1221 LAGAADFGLKYACANFTRKVLPARCEIPTETCHRFLDLTGPLQIGGLPNIPSSFQVKNKD 1280
T V+P C R L L +GGL + SS V ++
Sbjct: 3874 ----------------TSLVVPENC--------RGLRPERHLLLGGLILLHSSSNV-SQG 3908
Query: 1281 FVGCISDFYIDHKFIDL---NSYVA---DNGTLAGCPEKRSRCSSAPCYNGAECSDLWDT 1334
F GC+ ++ + +DL VA + L C CS C NG +CS
Sbjct: 3909 FEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGGKCSWTHGA 3968
Query: 1335 -YICDCKEGHTGKDC 1348
Y+C C +GK C
Sbjct: 3969 GYVCKCPPQFSGKHC 3983
Score = 38.7 bits (86), Expect = 0.30
Identities = 61/263 (23%), Positives = 98/263 (37%), Gaps = 34/263 (12%)
Query: 1343 HTGKDCADSTGPPWRFGGDGMLSFNPLLRPIQLPWLNALSIRTRQRDAFVM--------S 1394
H + C+ G RF G + + P W ++T Q A ++ S
Sbjct: 3764 HLQRSCS-CNGTATRFSGQSYVRYRA---PAARNWHIHFYLKTLQPQAILLFTNETASVS 3819
Query: 1395 IQLKSGLLHYSYNG-ETMYLPMAT---LSDGAWHRIEIKWLGTDISVTVD-YGLRTVLMP 1449
++L SG+ Y+ Y +++ ++D WH I ++ + I + VD G ++++P
Sbjct: 3820 LKLASGVPQLEYHCLGGFYGNLSSQRHVNDHEWHSILVEEMDASIRLMVDSMGNTSLVVP 3879
Query: 1450 MLANKIQGQYIGKILIGGLDTTAGLLASDVGFFEGCIQDVRIGTAQSLLNRP------TV 1503
++ + +L+GGL GF EGC+ V + L P +
Sbjct: 3880 ENCRGLRPER--HLLLGGLILLHSSSNVSQGF-EGCLDAVVVNEEALDLLAPGKTVAGLL 3936
Query: 1504 RENVRDGCQSRAD-CMLSICPPYSKCV-TSWDSSTCTCEAGRVGPQCVSA---CELGPC- 1557
C +D C + C KC T C C G C C PC
Sbjct: 3937 ETQALTQCCLHSDYCSQNTCLNGGKCSWTHGAGYVCKCPPQFSGKHCEQGRENCTFAPCL 3996
Query: 1558 GAARCVPDQTPKGYSCACEPGYT 1580
C+ +PKG SC C YT
Sbjct: 3997 EGGTCI--LSPKGASCNCPHPYT 4017
Score = 37.5 bits (83), Expect = 0.69
Identities = 38/166 (22%), Positives = 65/166 (39%), Gaps = 7/166 (4%)
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAEL-----VTMVDLDYESPRKKYELVIRAASP 772
P V Y I GD +N F E + L + L R Y L+I+A
Sbjct: 65 PQWAVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEK 124
Query: 773 PLWNDV--RVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYR 830
L + RV + + D ND P+ +D P +V A DAD+ ++
Sbjct: 125 TLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFY 184
Query: 831 ILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEI 876
+ + ++ T+G +T++ +LN ++V D + +I
Sbjct: 185 YAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKI 230
Score = 35.9 bits (79), Expect = 2.1
Identities = 33/124 (26%), Positives = 52/124 (41%), Gaps = 18/124 (14%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+ C+CP F+G +CE + +C + C G C+ +G C+ YT
Sbjct: 3970 YVCKCPPQFSGKHCEQ--GRENCTF----APCLEGGTCILSPKGA----SCNCPHPYTGD 4019
Query: 1102 VCELRARSFPVSSFLTFPGLKRRH-------RIHLKLKFATQTTSGLLLYNGRYNERHDF 1154
CE+ AR L P ++R I + + F +T GLL Y R + H
Sbjct: 4020 RCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYCRRC-KSHKP 4078
Query: 1155 LALE 1158
+A+E
Sbjct: 4079 VAME 4082
>BC065284-1|AAH65284.1| 1381|Homo sapiens CDH23 protein protein.
Length = 1381
Score = 338 bits (831), Expect = 2e-91
Identities = 268/889 (30%), Positives = 411/889 (46%), Gaps = 75/889 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 500
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 501 ---DDP------------DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 541
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 542 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 597
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 598 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 657
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 658 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSRE----YGQESIIYSL 713
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG--DPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DGG ++ AT
Sbjct: 714 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 773
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 774 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKF--YSLNSTTG 831
Query: 420 RGLITVAQ-----PLDFKQERRYVLTVSATDSGG----RSDTAMVQINITDANNYAPVFE 470
+ T A P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 832 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 892 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP-------VGMPRMDFLINSSS 944
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 945 GVVVTTTELDRERIAKYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1004
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESV 650
ED V + TD DVGLN + Y + + +G F + V+RT LDRE+
Sbjct: 1005 SEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN-VDGKFSVGYRDAVVRTVVGLDRETT 1063
Query: 651 ATHDLKAVAIDGGTPPQ--SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A + L AID G + + T V + + D+ND+ P+F + E+ P G +I +
Sbjct: 1064 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1123
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
++A D DEG V Y I G+ N+F + G + LD E + L++
Sbjct: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG---LLMRGPRPLDRER-NSSHVLIVE 1179
Query: 769 AASP---PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVT 824
A + P+ + VRV + V D+ND APV Q ++ +G V A D D
Sbjct: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
Query: 825 D--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D + YRILSG ++E+TG + L+ M VS TD
Sbjct: 1240 DGGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATD 1287
Score = 316 bits (777), Expect = 6e-85
Identities = 263/903 (29%), Positives = 425/903 (47%), Gaps = 69/903 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV-LTLKATDQDIGKNAEVEYTIELVTADT 69
I V+D ND++P F +Y ++ E A G + L ++ D+D + + LV ++
Sbjct: 336 ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS 395
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRA-SLDREKVARYTVLVKATDQASPVSD 128
+ + + G++ + A LD E V RY + A + V D
Sbjct: 396 HH-------------FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES---VPD 439
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ A + + +I++NDN P FS+ Y +S+ E+++V + + + ATD D G +
Sbjct: 440 HVGY-AKVKITLINENDNRPIFSQPLYNISLYENVTVGTS--VLTVLATDNDAGTFGEVS 496
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y + +FS+D +G + L+ LDYE ++ + L I A+DGG T ++ IN+
Sbjct: 497 YFF--SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVL 552
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F + ++ EN P +VR++A D D N ++TY++ G+
Sbjct: 553 DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY-FD 611
Query: 309 ITIDPRSGWVYTSGQLDRE--TQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I++ G + S LD E + L V A D G+PP ++T F
Sbjct: 612 ISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTF 671
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG--RFSITSQNGRGLIT 424
Y V + E+ G V+ L ATD D E + G +F I +++G IT
Sbjct: 672 SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGE--IT 729
Query: 425 VAQPLDFKQERRYVLTVSATDSG-GRSD-TAMVQINIT--DANNYAPVFENAPYTASVFE 480
LD + + Y+L V A D G G + T + +NIT D N+ P +++APY ++ E
Sbjct: 730 TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVE 789
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAI-TTNKLL 539
P + V V A D D+G N + YS+ ++ + +N TG I TT+ +L
Sbjct: 790 MTPPDSDVTTVVAVDPDLGENGTLVYSIQPP---------NKFYSLNSTTGKIRTTHAML 840
Query: 540 DRETMSGY------LLTVTARDGGVPSLSDTTD--VEISVVDVNDNEPVFKQQLYTANIM 591
DRE + + V+ D G P L T+ V ++++D+NDN+P F+ + A ++
Sbjct: 841 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 900
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVA 651
E G S+ QV A D D GLNG + Y + P F+I+ +SGV+ T LDRE +A
Sbjct: 901 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGMPRMDFLINSSSGVVVTTTELDRERIA 959
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
+ L+ VA D GTP +SST + I + D+ND P F +SE+ P + +
Sbjct: 960 KYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA- 770
D D G NA + Y I GG+ FS+ G A + T+V LD E+ Y L++ A
Sbjct: 1020 TDNDVGLNAELSYFITGGNVDGKFSV----GYRDAVVRTVVGLDRET-TAAYMLILEAID 1074
Query: 771 SPPL----WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTD- 825
+ P+ V + V DVNDN P+ + +D ++ A DAD +
Sbjct: 1075 NGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF 1134
Query: 826 -KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSV 884
++ YRIL GN+ N ++ + G + P+ + + V + + N M+ SV
Sbjct: 1135 GRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDR--ERNSSHVLIVEAYNHDLGPMRSSV 1192
Query: 885 RLI 887
R+I
Sbjct: 1193 RVI 1195
Score = 303 bits (744), Expect = 6e-81
Identities = 230/722 (31%), Positives = 349/722 (48%), Gaps = 56/722 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND+ P F Y SV E +G TVL L ATD D + E I + T
Sbjct: 659 IEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ 718
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
FRI+ RSG + T + LDRE + Y ++V+A D + +
Sbjct: 719 -------------------FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQK- 758
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ AT+++ ++D NDN+P + + Y +++ E ++ D+ V + A D D+G N + Y+
Sbjct: 759 TGIATVNITLLDINDNHPTWKDAPYYINLVE-MTPPDSDVTTVV-AVDPDLGENGTLVYS 816
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKT-LDYEQVRSY------RLVIRAQDGGSPSRSNTTQ- 242
I N +S++S +G + LD E + ++V+ D G P T+
Sbjct: 817 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
Query: 243 -LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ +N+ D+NDN P F F V E +P G SI +V A D DEG+N ++Y M
Sbjct: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP---- 930
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
G + I+ SG V T+ +LDRE AKYQL V A+D G P +S+T+T
Sbjct: 931 VGMPRMDFLINSSSGVVVTTTELDRERIAKYQLRVVASDAGTPTKSSTSTLTIHVLDVND 990
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F P Y V ++ED P VV L TD D + L Y ITGGN G+FS+ ++
Sbjct: 991 ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDA 1050
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GR--SDTAMVQINITDANNYAPVFENAPYT 475
++ LD + Y+L + A D+G G+ + TA V + + D N+ P+F + Y
Sbjct: 1051 --VVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYE 1108
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
ASV ED P G ++L + ATD+D G ++ Y + +H F I+ G +
Sbjct: 1109 ASVPEDIPEGHSILQLKATDADEGEFGRVWYRILH-------GNHGNNFRIHVSNGLLMR 1161
Query: 536 N-KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA-NIMED 593
+ LDRE S ++L V A + + + + V + V D+ND PVF QQ Y+ + E
Sbjct: 1162 GPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRET 1221
Query: 594 ALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATH 653
A +GTSV V ATD D G G ++Y + EG F ID ++G+I T LD E+ ++
Sbjct: 1222 AGIGTSVIVVQATDRDSGDGGLVNYRI--LSGAEGKFEIDESTGLIITVNYLDYETKTSY 1279
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
+ A D P V+I + + D F + I EN +GT I ++A+
Sbjct: 1280 MMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYS 1339
Query: 714 PD 715
D
Sbjct: 1340 ID 1341
Score = 299 bits (735), Expect = 7e-80
Identities = 256/828 (30%), Positives = 389/828 (46%), Gaps = 86/828 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I + D D P+F Y ++ E + GTTV + A DQD G+ + YTI V+ +T
Sbjct: 224 IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI--VSGNT- 280
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVAR---YTVLVKAT---DQAS 124
+F +D SG L LDRE + + VK T D +
Sbjct: 281 ----------------NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
Query: 125 PVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISV-TDNPVIAKIKATDADVGA 183
P SD + T T ++ +ID NDN P+F+ Y+V++ E V P+ ++ D ++G
Sbjct: 325 P-SDA-TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
Query: 184 NSAIRYAIIGGNT-QMQFSIDSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRS 238
NS ++G N+ S S+ G + + LDYE V Y + A + P
Sbjct: 383 NSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHV 441
Query: 239 NTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD 298
++ I + + NDN P F L+ S+ ENV +G S++ V A D D G E++Y +D
Sbjct: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
Query: 299 KDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
+ D ++D +G + +LD E ++ L + A DGG T
Sbjct: 502 -----DPD-RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLD 553
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGR-FSIT 415
F Y L E+EP T +V L ATD D +N++ Y I + G F I+
Sbjct: 554 VNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS 613
Query: 416 SQNGRGLITVAQPLDFKQ--ERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFEN 471
G G+I+V++PLD++Q LTV A D+G + T V I + D N+ P F
Sbjct: 614 LYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSK 673
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH---DQQFVINP 528
Y SV E+ G TVL ++ATD D S E E++ + QF IN
Sbjct: 674 PAYFVSVVENIMAGATVLFLNATDLD----------RSREYGQESIIYSLEGSTQFRINA 723
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT--TDVEISVVDVNDNEPVFKQQLY 586
++G ITT LLDRET S Y+L V A DGGV T V I+++D+NDN P +K Y
Sbjct: 724 RSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPY 783
Query: 587 TANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-L 645
N++E + V+ V A D D+G NG + Y + P ++ + ++ +G IRT A L
Sbjct: 784 YINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK---FYSLNSTTGKIRTTHAML 840
Query: 646 DRESVATHD---LKAVAI---DGGTPP--QSSTVIVHIKIEDINDSPPVFESDCLTFYIS 697
DRE+ H+ ++ + + D G PP +S+ V + + D+ND+ P F++ +
Sbjct: 841 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 900
Query: 698 ENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYE 757
E P G +I ++ A D DEG N +V Y + G F + + G +VT +LD E
Sbjct: 901 EGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG----VVVTTTELDRE 956
Query: 758 SPRKKYELVI---RAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
KY+L + A +P + + I V DVND P F ++N
Sbjct: 957 R-IAKYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF--FPAVYN 1001
Score = 299 bits (735), Expect = 7e-80
Identities = 237/796 (29%), Positives = 375/796 (47%), Gaps = 53/796 (6%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 548 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 605
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVL--VKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 606 FG-------------SYFDISLYEGY-GVISVSRPLDYEQISNGLIYLTVMAMDAGNPP- 650
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 651 --LNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 706
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 707 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 766
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT--DKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 767 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 826
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 827 NSTTG-KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 885
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +G
Sbjct: 886 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG 945
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTAS 477
++ LD ++ +Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 946 --VVVTTTELDRERIAKYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1003
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V ED P V+ ++ TD+DVG+NA+++Y ++ + D +F + + + T
Sbjct: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITG-------GNVDGKFSVGYRDAVVRTVV 1056
Query: 538 LLDRETMSGYLLTVTARDGGVPSL--SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
LDRET + Y+L + A D G + T V ++V+DVNDN P+F Q Y A++ ED
Sbjct: 1057 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIP 1116
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVI-RTNKALDRESVATHD 654
G S+ Q+ ATDAD G GR+ Y + +F I ++G++ R + LDRE ++H
Sbjct: 1117 EGHSILQLKATDADEGEFGRVWYRI-LHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-ESDCLTFYISENSPIGTTIGEIRAHD 713
L A + P S+V V + +EDIND PVF + + E + IGT++ ++A D
Sbjct: 1176 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATD 1235
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPP 773
D G +V+Y I G + F ++ G ++T+ LDYE+ V P
Sbjct: 1236 RDSGDGGLVNYRILSGAE-GKFEIDESTGL----IITVNYLDYETKTSYMMNVSATDQAP 1290
Query: 774 LWNDVRVEILVTDVND 789
+N + +T +N+
Sbjct: 1291 PFNQGFCSVYITLLNE 1306
Score = 273 bits (669), Expect = 7e-72
Identities = 250/876 (28%), Positives = 390/876 (44%), Gaps = 71/876 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND++P F Q Y + E GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ------- 172
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F ID G + LD E Y + V ATDQ + L
Sbjct: 173 -PP-------------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK--TRPL 216
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+ A + + I D D P F Y+ ++ E + I A D D G I Y
Sbjct: 217 STLANLAIIITDVQDMDPIFINLPYSTNIYE--HSPPGTTVRIITAIDQDKGRPRGIGYT 274
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSRSN-TTQL 243
I+ GNT F++D +SG ++L LD E + S+ ++ + D +PS + TT
Sbjct: 275 IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADE--GVNAELTYTMTDKD 300
I + D+NDNAP F +S + +++E +G+++ + +Q D DE G+N+ + +
Sbjct: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
Query: 301 YTGNVDLPITIDPRSG-WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINE 453
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F Y + L E+ GT V+T+ ATD D + RFS+
Sbjct: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDT- 512
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVF 479
GLI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y ++
Sbjct: 513 -GLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALR 571
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P T ++ + ATD D N QITYS+ +S A + + G I+ ++ L
Sbjct: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVISVSRPL 627
Query: 540 DRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
D E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E+ + G
Sbjct: 628 DYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAG 687
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESVATHDL 655
+V + ATD D R + + EGS F I+ SG I T LDRE+ + + L
Sbjct: 688 ATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYIL 744
Query: 656 KAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
A+DGG T I V+I + DIND+ P ++ + E +P + + + A D
Sbjct: 745 IVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVD 804
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------RKKYEL 765
PD G N + YSI+ + +SL + G + T LD E+P RK
Sbjct: 805 PDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMRKIVVS 859
Query: 766 VIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDAD 822
V PPL + V + + D+NDN P ++ + + P G +V A D D
Sbjct: 860 VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVVAIDLD 918
Query: 823 --VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
+ + YR+ G L+N ++G + + +L+
Sbjct: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
Score = 270 bits (662), Expect = 5e-71
Identities = 200/618 (32%), Positives = 299/618 (48%), Gaps = 39/618 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND+ P ++ Y ++ E + V T+ A D D+G+N + Y+I+
Sbjct: 766 ITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ------- 818
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P + ++ + R A L R+ ++V TD P +
Sbjct: 819 -PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK------IVVSVTDCGRPPL-KA 870
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+S+AT+ VN++D NDN P F + V E I + I ++ A D D G N + Y
Sbjct: 871 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVS--IYQVVAIDLDEGLNGLVSYR 928
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ G +M F I+S SG V LD E++ Y+L + A D G+P++S+T+ L I++ DV
Sbjct: 929 MPVGMPRMDFLINSSSGVVVTTTELDRERIAKYQLRVVASDAGTPTKSSTSTLTIHVLDV 988
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
ND P F+ +++ SVSE+VP + +V + D D G+NAEL+Y +T GNVD +
Sbjct: 989 NDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG----GNVDGKFS 1044
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR--SATATXXXXXXXXXXXXXXFMP 368
+ R V T LDRET A Y L++ A D G + + TAT F+
Sbjct: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRGLITVA 426
YE + ED P G ++ L ATDADE R+ Y I GN F I NG L+
Sbjct: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGL-LMRGP 1163
Query: 427 QPLDFKQERRYVLTVSA--TDSGGRSDTAMVQINITDANNYAPVFENAPYT-ASVFEDAP 483
+PLD ++ +VL V A D G + V + + D N+ APVF Y+ + E A
Sbjct: 1164 RPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1223
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
IGT+V+VV ATD D G + Y + S + +F I+ TG I T LD ET
Sbjct: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGA--------EGKFEIDESTGLIITVNYLDYET 1275
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y++ V+A D P V I++++ D F Y A I+E+ +GT + +V
Sbjct: 1276 KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRV 1335
Query: 604 GATDADVGLNGRIHYELD 621
A D LN +I Y D
Sbjct: 1336 QAYSID-NLN-QITYRFD 1351
Score = 269 bits (659), Expect = 1e-70
Identities = 254/873 (29%), Positives = 397/873 (45%), Gaps = 85/873 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDV 209
F + Y+V + E+ V P+ + ATD D+GA ++ Y+ F+IDS G V
Sbjct: 132 FHNQPYSVRIPENTPV-GTPIFI-VNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIV 187
Query: 210 SLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQESVSE 268
++++ LDYE ++Y+L + A D +T L I I DV D P F + ++ E
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 247
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRET 328
+ P G ++ + A D D+G + YT+ +GN + +D SG + +G LDRE
Sbjct: 248 HSPPGTTVRIITAIDQDKGRPRGIGYTIV----SGNTNSIFALDYISGVLTLNGLLDREN 303
Query: 329 ---QAKYQLLVTATDGGD--PPRSATATXXXXXXXXXXXXXX--FMPGQYEVELAEDEPP 381
+ L V T+ D P AT T F +Y V + E
Sbjct: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQV 363
Query: 382 GTPV-VTLTATDADEDNRLH--YEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFKQ 433
G + + + D DE+ L+ +E+ GN F I TS G+ I VA PLD++
Sbjct: 364 GFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET 423
Query: 434 ERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVS 492
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 424 VDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 484 ATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTII 534
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 535 ARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP 592
Query: 613 NGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQS 668
N +I Y + F I GVI ++ LD E ++ L +A+D G PP +
Sbjct: 593 NNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLN 652
Query: 669 STVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVHY 724
STV V I++ D ND+PP F + EN G T+ + A D D G +++ Y
Sbjct: 653 STVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-Y 711
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR----- 779
S++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 712 SLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIAT 763
Query: 780 VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNNA 837
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 764 VNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-- 821
Query: 838 NLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 822 KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV----- 876
Query: 890 EMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 877 --FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 905
Score = 220 bits (538), Expect = 5e-56
Identities = 193/650 (29%), Positives = 279/650 (42%), Gaps = 49/650 (7%)
Query: 167 DNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLV 226
D PV + + A N + + + G F+++ +G V L + LD E + +
Sbjct: 45 DTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVE 104
Query: 227 IRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADE 286
D T ++ I + DVNDNAP F+ + + EN P+G I V A D D
Sbjct: 105 FSVSDHQGVI---TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDL 161
Query: 287 GVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP-P 345
G + Y+ ID G V +LD ET YQL V ATD P
Sbjct: 162 GAGGSVLYSFQPPSQF------FAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
Query: 346 RSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI 403
S A F+ Y + E PPGT V +TA D D+ + Y I
Sbjct: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
Query: 404 TGGNTRGRFSITSQNG----RGLITVAQPLDFKQERRYVLTVSAT---DSGGRSD---TA 453
GNT F++ +G GL+ PL ++LTV T D SD T
Sbjct: 276 VSGNTNSIFALDYISGVLTLNGLLDRENPL---YSHGFILTVKGTELNDDRTPSDATVTT 332
Query: 454 MVQINITDANNYAPVFENAPYTASVFEDAPIGTTV-LVVSATDSDVGINAQITYSLSSEI 512
I + D N+ AP F ++ Y+ ++ E A +G + L + D D + L+S
Sbjct: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL------GLNSMF 386
Query: 513 SNEAVAHHDQQFVINPQTG------AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTD 566
V ++ F+I+P + I LD ET+ Y + A + VP
Sbjct: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAK 445
Query: 567 VEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL-DPKDR 625
V+I++++ NDN P+F Q LY ++ E+ VGTSV V ATD D G G + Y D DR
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR 505
Query: 626 EEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPP 685
F +D +G+I LD E + L +A DGG + +T V I + D+ND+ P
Sbjct: 506 ----FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVP 559
Query: 686 VFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS-FSLETRQGSD 744
F+ D + EN P T + +RA D D PN + YSI S F + +G
Sbjct: 560 TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
Query: 745 KAELVTMVDLDYESPRKKYELVIR--AASPPLWNDVRVEILVTDVNDNAP 792
+ +D + S Y V+ A +PPL + V V I V D NDN P
Sbjct: 620 VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
Score = 185 bits (450), Expect = 2e-45
Identities = 167/566 (29%), Positives = 258/566 (45%), Gaps = 60/566 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEE----ASRFFAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + + D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVS---DHQGVITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLITVAQP 428
+ E+ P GTP+ + ATD D GG+ F SQ + RG++TV +
Sbjct: 140 RIPENTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIVTVIRE 192
Query: 429 LDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E +P G
Sbjct: 193 LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPG 252
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET-- 543
TTV +++A D D G I Y++ S +N F ++ +G +T N LLDRE
Sbjct: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSI-------FALDYISGVLTLNGLLDRENPL 305
Query: 544 -MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
G++LTV D PS + TT I V+D+NDN P F Y+ I E A VG
Sbjct: 306 YSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGF 365
Query: 599 SVS---QVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALDRES 649
++ QV D ++GLN +E+ F+I P S IR LD E+
Sbjct: 366 ALPLFIQVVDKDENLGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET 423
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
V +D A + P V I + + ND+ P+F + EN +GT++ +
Sbjct: 424 VDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
Query: 710 RAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
A D D G V Y DD + FSL+ D ++ + LDYE ++ +I
Sbjct: 483 LATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTIIAR 536
Query: 770 ASPPLWNDVRVEILVTDVNDNAPVMK 795
RV I V DVNDN P +
Sbjct: 537 DGGGEETTGRVRINVLDVNDNVPTFQ 562
Score = 175 bits (425), Expect = 2e-42
Identities = 143/514 (27%), Positives = 233/514 (45%), Gaps = 27/514 (5%)
Query: 375 LAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQE 434
++ED P G+ V L A D D D L + ++G F++ G ++ + QPLD + +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDP-LVFGVSGEEASRFFAVEPDTG--VVWLRQPLDRETK 98
Query: 435 RRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSAT 494
+ + S +D G T V I + D N+ AP F N PY+ + E+ P+GT + +V+AT
Sbjct: 99 SEFTVEFSVSDHQGVI-TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
Query: 495 DSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
D D+G + YS Q F I+ G +T + LD ET Y LTV A
Sbjct: 158 DPDLGAGGSVLYSFQPP---------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
Query: 555 D-GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D LS ++ I + DV D +P+F Y+ NI E + GT+V + A D D G
Sbjct: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-VATH----DLKAVAIDGGTPPQS 668
I Y + F +D SGV+ N LDRE+ + +H +K ++ P
Sbjct: 269 RGIGYTI-VSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 327
Query: 669 STVIV--HIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDE--GPNAVVH 723
+TV +I + DIND+ P F S + I+E + +G + I+ D DE G N++
Sbjct: 328 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387
Query: 724 YSIKGGDDSNSFSLETR-QGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDVRVE 781
+ G + + T QG + + LDYE+ R ++L + P +V+
Sbjct: 388 VYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVK 447
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLIL 841
I + + NDN P+ + Y++ V A D D + ++ +
Sbjct: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFS 507
Query: 842 LNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNE 875
L++ TG + L +L+ + + T+ + DG E
Sbjct: 508 LDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE 541
>AB053446-1|BAB61903.2| 3434|Homo sapiens KIAA1773 protein protein.
Length = 3434
Score = 314 bits (770), Expect = 4e-84
Identities = 253/819 (30%), Positives = 377/819 (46%), Gaps = 52/819 (6%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
ID SG + T LDRE+ RY D A T + V + D ND+ P F
Sbjct: 230 IDEHSGVVRTARVLDREQRDRYRFTAVTPDGA---------TVEVTVRVADINDHAPAFP 280
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGD--- 208
+ + V E + + A DAD G YA+ G F +++ G
Sbjct: 281 QARAALQVPEHTAFGTRYPLEP--ARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGT 338
Query: 209 --VSLVKT--LDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
LV T LD E Y L + A DGGSP R L + + D+ND+AP F S +
Sbjct: 339 PVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHA 398
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
VSE++ G +++V A DAD GVN +TY + + G D P +ID +G + L
Sbjct: 399 VVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEG--DGPFSIDAHTGLLQLERPL 456
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXX----XXXXXFMPGQYEVELAEDEP 380
D E + ++L+V A DGG P +A F+ +++E P
Sbjct: 457 DFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAP 516
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG-RGLITVAQPLDFKQERRYVL 439
PG V ++ +D D+ + H ++ G F++++Q+ L+ VA+ LD ++ Y L
Sbjct: 517 PGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNL 576
Query: 440 TVSATDSGG---RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPI-GTTVLVVSATD 495
V+ATDSG R++ A V +++TD N+ AP F+ Y + + G+ V+ V+A D
Sbjct: 577 RVTATDSGSPPLRAEAAFV-LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARD 635
Query: 496 SDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
D G N Q+TYSL A H F I+P +G ITT LD E L V A D
Sbjct: 636 PDQGTNGQVTYSL-------APGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATD 688
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGR 615
GG+P L+ + V +++ DVNDNEP F++ Y A++ E GT QV ATDAD G G
Sbjct: 689 GGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGL 748
Query: 616 IHYELDPKDREEGS--FVIDPASGVIRTNKALDR-ESVATHDLKAVAIDGGTPPQSSTVI 672
+ Y L GS F ID SG + T + LDR + ++ D A+DGG S V
Sbjct: 749 LSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVY 806
Query: 673 VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDS 732
V + + D ND+PP F IS SP GT + +RAHDPD+G + + Y I G+
Sbjct: 807 VKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSP 866
Query: 733 NSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVND 789
F+L+ + G L+T+ +L I A RV+I +
Sbjct: 867 PLFTLDEQSG-----LLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTP 921
Query: 790 NAPVMKDFQIIFNNYKDCFPVGPFGRVPAYD-ADVTDKLQYRILSGNNANLILLNETTGS 848
P+ + Q +F+ +D P G V A++ + + G+ L L+ +G
Sbjct: 922 TPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 981
Query: 849 M-TLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRL 886
+ TL P + + +EV GV A+ ++ V L
Sbjct: 982 LQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLL 1020
Score = 310 bits (762), Expect = 4e-83
Identities = 257/812 (31%), Positives = 391/812 (48%), Gaps = 82/812 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEAS------VREGASSGTTVLTLKATDQDIGKNAEVEYTIEL 64
+ VLD ND+SP F A V + GT V TL+A D D G+N + YT+
Sbjct: 1335 VAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT- 1393
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQAS 124
P ++F + SG LLT A L R + Y + + A DQ S
Sbjct: 1394 ------GPGS-------------ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGS 1434
Query: 125 PVSDRLSSTATIHVNIIDD---NDNYPQFSEKTYTVSVDEDISVT------DNPVIAKIK 175
P S++ + V ++ + P +E+ V ++VT ++ +
Sbjct: 1435 PPR---SASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVA 1491
Query: 176 ATD-ADVGANSAIRYAIIGG-NTQMQFSIDSLSGDVSLVKTLDYEQVRSYR-LVIRAQ-D 231
A + A VG A+ Y ++GG + + F++D+ SG + L + LD+E +R L +RA+
Sbjct: 1492 APEPAGVG---ALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGP 1548
Query: 232 GGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDAD-EGVNA 290
GG+ +R Q + ++D N++AP F ++ EN G ++ +A DAD G N+
Sbjct: 1549 GGAGARLLRVQ--VQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNS 1606
Query: 291 ELTYTMTDKDYTGNVDLP-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATD--GGDPPRS 347
++ Y + ++ +P + +D R+G + LDRET LLV ATD R
Sbjct: 1607 DVRYRLLRQE----PPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRR 1662
Query: 348 ATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITG 405
A V L ED+PPG + + A D D E R+ Y +
Sbjct: 1663 AARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLAS 1722
Query: 406 GNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDAN 463
G G F + S G ++V +PLD +Q +VLTV A+D G RS T ++ +++ D N
Sbjct: 1723 GGD-GHFRLHSST--GALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVN 1779
Query: 464 NYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQ 523
+ AP F+ Y+ + E+ P GT++L + ATD DVG N Q+TY +S+E+
Sbjct: 1780 DEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY---GGVSSES------- 1829
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ 583
F ++P TG +TT + LDRE LTV A+D G P V ++V D ND+ P F
Sbjct: 1830 FSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGS 1889
Query: 584 QLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNK 643
+ + E T ++ + A+D DVG NG++ Y + D G+FV+D ASG T +
Sbjct: 1890 AHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDGD-PSGAFVLDLASGEFGTMR 1947
Query: 644 ALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIG 703
LDRE L+ A DGG P S+T+++ + + D ND P F + + E+ P G
Sbjct: 1948 PLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAG 2007
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKK 762
T + +++AHDPD G N V Y + G + +F LE G EL T LD E P
Sbjct: 2008 TLLLQLQAHDPDAGANGHVTYYL-GAGTAGAFLLEPSSG----ELRTAAALDREQCPSYT 2062
Query: 763 YEL--VIRAASPPLWNDVRVEILVTDVNDNAP 792
+ + V AA+ PL V V I V DVND+AP
Sbjct: 2063 FSVSAVDGAAAGPLSTTVSVTITVRDVNDHAP 2094
Score = 305 bits (749), Expect = 1e-81
Identities = 241/793 (30%), Positives = 359/793 (45%), Gaps = 66/793 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
++V D ND +P F+ Q+Y +RE GT++LTL+ATD D+G N +V Y
Sbjct: 1773 VSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY---------- 1822
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F +D +G L T +LDRE+ + V A D+ SP
Sbjct: 1823 ------------GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQ--- 1867
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ T+ V + D+ND+ P F ++ V E D + ++A+D DVGAN ++Y
Sbjct: 1868 LTHVTVRVAVEDENDHAPTFGSAHLSLEVPEG---QDPQTLTMLRASDPDVGANGQLQYR 1924
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
I+ G+ F +D SG+ ++ LD E +++L I A+DGG P+ S T L + + D
Sbjct: 1925 ILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDA 1984
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
ND+AP F + V E+VP G ++++QA+D D G N +TY + G
Sbjct: 1985 NDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLG----AGTAG-AFL 2039
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP-PRSATATXXXXXXXXXXXXXXFMPG 369
++P SG + T+ LDRE Y V+A DG P S T + F
Sbjct: 2040 LEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTS 2099
Query: 370 QYEVELAEDEP----PGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLI 423
+ L P P + TL A D D + + Y + G G T + G I
Sbjct: 2100 PLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPG---TTVDSYTGEI 2156
Query: 424 TVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFED 481
VA+ R VL + ATD G RS T ++ + + P F A A++ E+
Sbjct: 2157 RVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIREN 2216
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL--L 539
AP GT ++ A + G N ITYS+ S NE F I P TGAIT L
Sbjct: 2217 APPGTPIVSPRAVHAG-GTNGPITYSILS--GNE-----KGTFSIQPSTGAITVRSAEGL 2268
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E L + A GG + T + +++ D NDN P F + Y A + E +
Sbjct: 2269 DFEVSPRLRLVLQAESGGAFAF---TVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGP 2325
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
+ QV A D D G G+I Y L G F +DP +G I T LDRE A L +A
Sbjct: 2326 LLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMA 2385
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G+P + + + + D ND+ P +SE++ +G+ I ++ +D D GP
Sbjct: 2386 TDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGP- 2443
Query: 720 AVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR 779
V+ Y + + FS+ G + LD+E +Y+L + A P
Sbjct: 2444 -VLWYVLSPSGPQDPFSV----GRYGGRVSLTGPLDFEQ-CDRYQLQLLAHDGPHEGRAN 2497
Query: 780 VEILVTDVNDNAP 792
+ +LV DVNDNAP
Sbjct: 2498 LTVLVEDVNDNAP 2510
Score = 300 bits (737), Expect = 4e-80
Identities = 234/786 (29%), Positives = 361/786 (45%), Gaps = 46/786 (5%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ +LD NDH+P F +Y A V E + G+ VL + A+D D G N V Y I ++
Sbjct: 379 VTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGD 438
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F ID +G L LD E+ + ++V+A D + +
Sbjct: 439 GP-----------------FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAH-PELG 480
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNP--VIAKIKATDADVGANSAIR 188
S+ T+HV D NDN P + + +S P ++A+I +D D G + +
Sbjct: 481 SAFVTVHVR--DANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVN 538
Query: 189 YAIIGGNTQMQFSI-DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
++ GG S DS+ V + + LD E+ +Y L + A D GSP ++++
Sbjct: 539 VSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHV 598
Query: 248 RDVNDNAPRFYTSLFQ-ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
DVNDNAP F L++ E + E G +VRV A D D+G N ++TY++ +T
Sbjct: 599 TDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTH--- 655
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+IDP SG + T+ LD E + + QL+V ATDGG PP +++AT F
Sbjct: 656 -WFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQF 714
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADED--NRLHYEITGG-NTRGRFSITSQNGRGLI 423
Y L E PGT + +TATDAD L Y + G + G G +
Sbjct: 715 QRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDV 774
Query: 424 TVAQPLDFKQ-ERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+ LD Q + TV+A D GG V++ ++D N+ P F Y AS+ +
Sbjct: 775 CTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQS 834
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
P GT VL + A D D G + +++Y + + F ++ Q+G +T L R
Sbjct: 835 PPGTAVLRLRAHDPDQGSHGRLSYHI-------LAGNSPPLFTLDEQSGLLTVAWPLARR 887
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
S L + A DGG + V+IS+V P+F+Q Y ++ ED GTSV
Sbjct: 888 ANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGI 947
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDG 662
V A + G + L D G F +D SG+++T + LDRE + V
Sbjct: 948 VQAHNPP-GRLAPVTLSLSGGD-PRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGS 1005
Query: 663 GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
G PP + V + ++D+ND+ P F + T + N+ GT I +RA DPD G N+ V
Sbjct: 1006 GVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRV 1065
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWNDVRVE 781
+++ G +F+++ G L+ + P + EL R SPP + R+
Sbjct: 1066 TFTLLAG-GGGAFTVDPTTG--HVRLMRPLG-PSGGPAHELELEARDGGSPPRTSHFRLR 1121
Query: 782 ILVTDV 787
++V DV
Sbjct: 1122 VVVQDV 1127
Score = 292 bits (716), Expect = 1e-77
Identities = 257/913 (28%), Positives = 420/913 (46%), Gaps = 87/913 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASV-REGASSGTTVL---TLKATDQDIGKNAEVEYTIELVT 66
I V D NDH+P F + R G S T L TL+A D+D G NA + Y +
Sbjct: 2084 ITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL---- 2139
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
A T P R+ RS L R++V + + ATD P
Sbjct: 2140 AGTPPPGTTVDSYTGE-------IRV-ARSPVALG----PRDRV----LFIVATDLGRPA 2183
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
S+T I V + + + P+F + ++ E+ + P+++ +A A G N
Sbjct: 2184 R---SATGVIIVGLQGEAERGPRFPRASSEATIREN-APPGTPIVSP-RAVHAG-GTNGP 2237
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSL--VKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
I Y+I+ GN + FSI +G +++ + LD+E RLV++A+ GG+ + T L
Sbjct: 2238 ITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFA---FTVLT 2294
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D NDNAPRF + + E+ P+ +++V+A D D+G +++Y++
Sbjct: 2295 LTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARG 2354
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ +DP +G + T+ LDRE A+ +L++ ATD G P +AT
Sbjct: 2355 L---FHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRP 2411
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
+P +E+ ++ED G+ + +T D D L Y ++ + FS+ GR ++
Sbjct: 2412 T-IPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGR--VS 2468
Query: 425 VAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPI 484
+ PLDF+Q RY L + A D G A + + + D N+ AP F + Y + E P
Sbjct: 2469 LTGPLDFEQCDRYQLQLLAHD-GPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPP 2527
Query: 485 GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT---NKLLDR 541
G+ +L VSATD D G N I+Y L+S F ++P G + T L
Sbjct: 2528 GSAILSVSATDRDSGANGHISYHLASPADG---------FSVDPNNGTLFTIVGTVALGH 2578
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVS 601
+ + + ARD G P + V + + D ND+ P F Y + ED G+++
Sbjct: 2579 DGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLL 2638
Query: 602 QVGATDAD-------------VGLNGRIHYELDPKDREEG-SFVIDP-ASGVIRTNKALD 646
+ ATDAD G GR+ ++L+P+ E G S P A G + + LD
Sbjct: 2639 TLEATDADGSRSHAAVDYSIISGNWGRV-FQLEPRLAEAGESAGPGPRALGCLVLLEPLD 2697
Query: 647 RESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
ES+ ++L A D G PPQSS V V + + D+ND+PPVF + E++P+G +
Sbjct: 2698 FESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAEL 2757
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
+ A D D GP+ +V +++ GD S F L+ G+ L +D + ++ +++LV
Sbjct: 2758 LHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGT--LRLAHALDCETQA---RHQLV 2812
Query: 767 IRAASP--PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDAD- 822
++AA P + V I V DVND+ P ++ + + P G + A D D
Sbjct: 2813 VQAADPAGAHFALAPVTIEVQDVNDHGPAF-PLNLLSTSVAENQPPGTLVTTLHAIDGDA 2871
Query: 823 -VTDKLQYRILSG----NNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIK 877
+L+Y +L LN +TG + + + + V D N +
Sbjct: 2872 GAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN-LS 2930
Query: 878 AMMQLSVRLITEE 890
A + +SV L+T E
Sbjct: 2931 ASVTVSV-LVTGE 2942
Score = 291 bits (713), Expect = 3e-77
Identities = 259/891 (29%), Positives = 401/891 (45%), Gaps = 76/891 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++++L+ N+HSP +V E GT+V + ATD+D G N + Y+++ ++ D+
Sbjct: 1228 RVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDS 1287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
FRI ++G + T +LDRE+ + Y +LV+ D SP
Sbjct: 1288 ------------------KAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPR-- 1327
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN----PVIAKIKATDADVGANS 185
S+T T+HV ++D NDN P F + + I V D ++ ++A D D G N
Sbjct: 1328 -STTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENG 1386
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
I Y + G +++ FS+ SG++ L + Y L + A D GSP RS + QLL+
Sbjct: 1387 TILYTLTGPGSEL-FSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLV 1445
Query: 246 NIR----------DVNDNAPRFYTSL-FQESVSENVPIGYSIVRVQAYDADEGVNAELTY 294
+ D+ + P + + +E + G S++ A GV A LTY
Sbjct: 1446 QVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPG-SLLGSVAAPEPAGVGA-LTY 1503
Query: 295 TMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
T+ + + +D SG +Y + LD E ++ L +G +
Sbjct: 1504 TLVGG---ADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQV 1560
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD---EDNRLHYEITGGNTRGR 411
F + L E+ PG + T A+DAD ++ + Y +
Sbjct: 1561 QVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVP 1620
Query: 412 FSITSQNGRGLITVAQPLDFKQERRYVLTVSATD-----SGGRSDTAMVQINITDANNYA 466
++ G ++ + LD + +L V ATD S R+ ++ +TD N+ A
Sbjct: 1621 -ALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNA 1679
Query: 467 PVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
PVF + P + ED P G L V A D D+G A+++Y L+S D F +
Sbjct: 1680 PVFAS-PSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASG--------GDGHFRL 1730
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLY 586
+ TGA++ + LDRE + ++LTV A D G P S T + +SV DVND P F+QQ Y
Sbjct: 1731 HSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEY 1790
Query: 587 TANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALD 646
+ + E+ GTS+ + ATD DVG NG++ Y SF +DP +GV+ T +ALD
Sbjct: 1791 SVLLRENNPPGTSLLTLRATDPDVGANGQVTY----GGVSSESFSLDPDTGVLTTLRALD 1846
Query: 647 RESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
RE +L A D G+PPQ + V V + +ED ND P F S L+ + E T+
Sbjct: 1847 REEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQD-PQTL 1905
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYE-SPRKKYEL 765
+RA DPD G N + Y I GD S +F L+ G E TM LD E P + +
Sbjct: 1906 TMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASG----EFGTMRPLDREVEPAFQLRI 1961
Query: 766 VIR-AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGP-FGRVPAYDAD- 822
R P L + + + V D ND+AP +D P G ++ A+D D
Sbjct: 1962 EARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPED-VPAGTLLLQLQAHDPDA 2020
Query: 823 -VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
+ Y L A LL ++G + + L+ T VS DG
Sbjct: 2021 GANGHVTY-YLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDG 2070
Score = 289 bits (709), Expect = 1e-76
Identities = 225/742 (30%), Positives = 345/742 (46%), Gaps = 74/742 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ + D ND++P F Y A + E +L ++A D D G ++ Y++
Sbjct: 2295 LTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSL-------- 2346
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ +F +D +G + T A LDRE A +++ ATD+ SP L
Sbjct: 2347 ----------AASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPA---L 2393
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+AT+ V +ID NDN P + + + V ED + IA++ D D G + Y
Sbjct: 2394 VGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSE--IAQVTGNDVDSGP--VLWYV 2448
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ Q FS+ G VSL LD+EQ Y+L + A DG R+N T L + DV
Sbjct: 2449 LSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVL---VEDV 2505
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDNAP F SL+Q + E+ P G +I+ V A D D G N ++Y + D +
Sbjct: 2506 NDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP-----AD-GFS 2559
Query: 311 IDPRSGWVYT---SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
+DP +G ++T + L + +++ A D G P R+A AT F
Sbjct: 2560 VDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFT 2619
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDADEDNRLH----YEITGGNTRGRFSITSQ------ 417
Y V + ED PPG+ ++TL ATDAD +R H Y I GN F + +
Sbjct: 2620 LSHYRVAVTEDLPPGSTLLTLEATDAD-GSRSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2678
Query: 418 ------NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVF 469
G + + +PLDF+ +Y LTV+A D G +++V + +T D N+ PVF
Sbjct: 2679 SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVF 2738
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
A Y +V ED P+G +L V A+D+D G + + +++SS F ++
Sbjct: 2739 TRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSS-------GDPSGLFELDES 2791
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
+G + LD ET + + L V A D + V I V DVND+ P F L + +
Sbjct: 2792 SGTLRLAHALDCETQARHQLVVQAADPAGAHFA-LAPVTIEVQDVNDHGPAFPLNLLSTS 2850
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYEL-----DPKDREEGSFVIDPASGVIRTNKA 644
+ E+ GT V+ + A D D G GR+ Y L P+ RE +F ++ ++G +R
Sbjct: 2851 VAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE--AFALNSSTGELRARVP 2908
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
D E + L A D G S TV V + ED D PVF + F + E + G
Sbjct: 2909 FDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD--PVFLAPAFHFQVPEGARRGH 2966
Query: 705 TIGEIRAHDPDEGPNAVVHYSI 726
++G ++A D D G + +V YS+
Sbjct: 2967 SLGHVQATDEDGGADGLVLYSL 2988
Score = 284 bits (697), Expect = 3e-75
Identities = 212/695 (30%), Positives = 314/695 (45%), Gaps = 29/695 (4%)
Query: 193 GGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVND 252
G +ID SG V + LD EQ YR DG T ++ + + D+ND
Sbjct: 221 GSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGA------TVEVTVRVADIND 274
Query: 253 NAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITID 312
+AP F + V E+ G A DAD G Y ++ L
Sbjct: 275 HAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPG 334
Query: 313 PRSGWV---YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
P V +G+LDRE ++ Y L + A DGG PPR A A F
Sbjct: 335 PDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQS 394
Query: 370 QYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQ 427
+Y ++E PG+PV+ + A+DAD + + YEI + G + GL+ + +
Sbjct: 395 RYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLER 454
Query: 428 PLDFKQERRYVLTVSATDSGGRSD--TAMVQINITDANNYAP----VFENAPYTASVFED 481
PLDF+Q R + L V A D G + +A V +++ DAN+ P +F +A + V E
Sbjct: 455 PLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEA 514
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
AP G V +S +D D G A + SL + A++ D + + + LDR
Sbjct: 515 APPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL------VCVARRLDR 568
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E Y L VTA D G P L + V DVNDN P F +QLY + E AL G+ V
Sbjct: 569 EERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFV 628
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+V A D D G NG++ Y L P F IDP SG+I T +LD E L VA
Sbjct: 629 VRVTARDPDQGTNGQVTYSLAPGAHTHW-FSIDPTSGIITTAASLDYELEPQPQLIVVAT 687
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG PP +S+ V + ++D+ND+ P F+ + E + GT ++ A D D GP
Sbjct: 688 DGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFG 747
Query: 721 VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA-SPPLWNDVR 779
++ YS+ G S S S R + ++ T LD + ++ + A L + V
Sbjct: 748 LLSYSLGAGLGS-SGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVY 806
Query: 780 VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTD--KLQYRILSGNNA 837
V++ ++D NDN P + + P R+ A+D D +L Y IL+GN+
Sbjct: 807 VKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSP 866
Query: 838 NLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L L+E +G +T++ L + +E+ DG
Sbjct: 867 PLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDG 901
Score = 281 bits (689), Expect = 3e-74
Identities = 234/800 (29%), Positives = 366/800 (45%), Gaps = 68/800 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEAS-VREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++V D ND++P F+ Q Y + E A G+ V+ + A D D G N +V Y++ A T
Sbjct: 596 LHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLA-PGAHT 654
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
F ID SG + T ASLD E + ++V ATD P
Sbjct: 655 ------------------HWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLP---P 693
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
L+S+AT+ V + D NDN PQF Y S+ E ++ ATDAD G + Y
Sbjct: 694 LASSATVSVALQDVNDNEPQFQRTFYNASLPE--GTQPGTCFLQVTATDADSGPFGLLSY 751
Query: 190 AI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQDGGSPSRSNTTQLLI 245
++ +G + F ID+ SGDV +TLD +Q S+ + A DGG + + +
Sbjct: 752 SLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKV 809
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
+ D NDN P+FY + S+S P G +++R++A+D D+G + L+Y + GN
Sbjct: 810 FLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHI----LAGNS 865
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
T+D +SG + + L R + QL + A DGG +A
Sbjct: 866 PPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 925
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTA-TDADEDNRLHYEITGGNTRGRFSITSQNGRGLIT 424
F QY + ED PGT V + A + ++GG+ RG FS+ + + GL+
Sbjct: 926 FEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVS--GLLQ 983
Query: 425 VAQPLDFKQERRYVLTVSATDSGG---RSDTAMVQINITDANNYAPVFENAPYTASVFED 481
+PLD ++ VL + G A V++ + D N+ +P F T + +
Sbjct: 984 TLRPLD-RELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPN 1042
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + + A D D G+N+++T++L +A F ++P TG + + L
Sbjct: 1043 TAPGTPIYTLRALDPDSGVNSRVTFTL--------LAGGGGAFTVDPTTGHVRLMRPLGP 1094
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDN--EPVFKQQLYTANIMEDALVGTS 599
+ L + ARDGG P + + + V DV P F Y ++ GT
Sbjct: 1095 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQ 1154
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
V QV A D G I Y L + F ++P SG + ALDRE+ + LK +A
Sbjct: 1155 VLQVQAQAPD---GGPITYHL-AAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMA 1210
Query: 660 IDGGTP---PQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
+ G Q+ T V + I + N+ P D ++EN P GT++G + A D D
Sbjct: 1211 VSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDS 1270
Query: 717 GPNAVVHYSIKG-GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR---AASP 772
GPN + YS++ +DS +F + + G E+ T+ LD E + Y+L+++ SP
Sbjct: 1271 GPNGRLTYSLQQLSEDSKAFRIHPQTG----EVTTLQTLDREQ-QSSYQLLVQVQDGGSP 1325
Query: 773 PLWNDVRVEILVTDVNDNAP 792
P V + V D+NDN+P
Sbjct: 1326 PRSTTGTVHVAVLDLNDNSP 1345
Score = 275 bits (674), Expect = 2e-72
Identities = 226/785 (28%), Positives = 357/785 (45%), Gaps = 45/785 (5%)
Query: 105 LDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDIS 164
LDRE+ Y + V ATD SP L + A +++ D NDN P F + Y +++
Sbjct: 566 LDREERDAYNLRVTATDSGSPP---LRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVA 622
Query: 165 VTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYR 224
+ + V+ ++ A D D G N + Y++ G FSID SG ++ +LDYE +
Sbjct: 623 LPGSFVV-RVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQ 681
Query: 225 LVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDA 284
L++ A DGG P +++ + + ++DVNDN P+F + + S+ E G ++V A DA
Sbjct: 682 LIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDA 741
Query: 285 DEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRET-QAKYQLLVTATDGGD 343
D G L+Y++ + P ID SG V T+ LDR+ + + VTA DGG
Sbjct: 742 DSGPFGLLSYSL-GAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG 800
Query: 344 PPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDN--RLHY 401
+ F P +Y ++ PPGT V+ L A D D+ + RL Y
Sbjct: 801 --LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSY 858
Query: 402 EITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINI 459
I GN+ F++ Q+ GL+TVA PL + L + A D GG +A V I+I
Sbjct: 859 HILAGNSPPLFTLDEQS--GLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISI 916
Query: 460 TDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
P+FE Y SV ED GT+V +V A + G A +T SLS
Sbjct: 917 VPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSG-------GD 968
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG-GVPSLSDTTDVEISVVDVNDNE 578
F ++ +G + T + LDRE + G +L + R G GVP V + + DVNDN
Sbjct: 969 PRGLFSLDAVSGLLQTLRPLDRELL-GPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNS 1027
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
P F T + + GT + + A D D G+N R+ + L G+F +DP +G
Sbjct: 1028 PAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTL--LAGGGGAFTVDPTTGH 1085
Query: 639 IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS--PPVFESDCLTFYI 696
+R + L H+L+ A DGG+PP++S + + ++D+ P F S +
Sbjct: 1086 VRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDL 1145
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDY 756
+ GT + +++A PD GP + Y + S+ F LE + G L LD
Sbjct: 1146 PSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSG----WLWVRAALDR 1198
Query: 757 ESPRKKYELVIRAAS------PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPV 810
E+ ++ Y L + A S V + + + N+++P + + ++ P
Sbjct: 1199 EA-QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPG 1257
Query: 811 GPFGRVPAYDAD--VTDKLQYRILS-GNNANLILLNETTGSMTLSPQLNTNVPKLATMEV 867
GRV A D D +L Y + ++ ++ TG +T L+ + V
Sbjct: 1258 TSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLV 1317
Query: 868 SVTDG 872
V DG
Sbjct: 1318 QVQDG 1322
Score = 268 bits (656), Expect = 3e-70
Identities = 244/854 (28%), Positives = 382/854 (44%), Gaps = 66/854 (7%)
Query: 18 DHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPEDAXX 77
+ P F EA++RE A GT +++ +A G N + Y+I L+ +
Sbjct: 2199 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSI-------LSGNE--- 2247
Query: 78 XXXXXXXXVQDVFRIDGRSGALLTRAS--LDREKVARYTVLVKATDQASPVSDRLSSTAT 135
+ F I +GA+ R++ LD E R ++++A S +
Sbjct: 2248 ---------KGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAE------SGGAFAFTV 2292
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
+ + + D NDN P+F Y + E + + P++ +++A D D G+ I Y++
Sbjct: 2293 LTLTLQDANDNAPRFLRPHYVAFLPESRPL-EGPLL-QVEADDLDQGSGGQISYSLAASQ 2350
Query: 196 -TQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNA 254
+ F +D +G ++ LD E RLV+ A D GSP+ + L + + D NDN
Sbjct: 2351 PARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNR 2410
Query: 255 PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPR 314
P ++ VSE+ +G I +V D D G L Y ++ +G D P ++
Sbjct: 2411 PTI-PQPWELRVSEDALLGSEIAQVTGNDVDSG--PVLWYVLSP---SGPQD-PFSVGRY 2463
Query: 315 SGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVE 374
G V +G LD E +YQL + A DG P A F Y+V
Sbjct: 2464 GGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVM 2520
Query: 375 LAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQE 434
L E PPG+ +++++ATD D H + FS+ NG L T+ + +
Sbjct: 2521 LLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGT-LFTIVGTVALGHD 2579
Query: 435 RRYVLTV--SATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLV 490
+ V A D G GR+ A V + + D N++AP F + Y +V ED P G+T+L
Sbjct: 2580 GSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLT 2639
Query: 491 VSATDSDVG-INAQITYSLSSEISNEA------VAHHDQQFVINPQT-GAITTNKLLDRE 542
+ ATD+D +A + YS+ S +A + P+ G + + LD E
Sbjct: 2640 LEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFE 2699
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
+++ Y LTV A D G P S V ++V+DVNDN PVF + Y + ED VG +
Sbjct: 2700 SLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLH 2759
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDG 662
V A+DAD G +G + + + D G F +D +SG +R ALD E+ A H L A D
Sbjct: 2760 VEASDADPGPHGLVRFTVSSGD-PSGLFELDESSGTLRLAHALDCETQARHQLVVQAADP 2818
Query: 663 GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
+ V I+++D+ND P F + L+ ++EN P GT + + A D D G +
Sbjct: 2819 AGA-HFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRL 2877
Query: 723 HYSI----KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDV 778
YS+ G + +F+L + G EL V DYE LV A + L V
Sbjct: 2878 RYSLLEAGPGPEGREAFALNSSTG----ELRARVPFDYEHTESFRLLVGAADAGNLSASV 2933
Query: 779 RVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD-VTDKLQYRILSGNNA 837
V +LVT ++ PV F + G V A D D D L L+ ++
Sbjct: 2934 TVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLA-TSS 2992
Query: 838 NLILLNETTGSMTL 851
+N+TTG++ L
Sbjct: 2993 PYFGINQTTGALYL 3006
Score = 265 bits (650), Expect = 1e-69
Identities = 226/778 (29%), Positives = 342/778 (43%), Gaps = 66/778 (8%)
Query: 15 DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNPED 74
D ND+ P F+ Y AS+ EG GT L + ATD D G + Y++ + +P
Sbjct: 706 DVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP- 764
Query: 75 AXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREK-VARYTVLVKATDQASPVSDRLSST 133
FRID SG + T +LDR++ + + V A D L S
Sbjct: 765 ---------------FRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGG-----LKSM 804
Query: 134 ATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIG 193
+ V + D+NDN PQF + Y S+ + +++A D D G++ + Y I+
Sbjct: 805 VYVKVFLSDENDNPPQFYPREYAASISAQSP--PGTAVLRLRAHDPDQGSHGRLSYHILA 862
Query: 194 GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDN 253
GN+ F++D SG +++ L +L I A+DGG + ++ I+I
Sbjct: 863 GNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPT 922
Query: 254 APRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
P F + SV E+V G S+ VQA++ G A +T +++ D G L D
Sbjct: 923 PPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSL----DA 977
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
SG + T LDRE L G PP A A F + V
Sbjct: 978 VSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTV 1037
Query: 374 ELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDF 431
L + PGTP+ TL A D D ++R+ + + G G F++ G + + +PL
Sbjct: 1038 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG-GAFTVDPTTGH--VRLMRPLGP 1094
Query: 432 KQERRYVLTVSATDSGGRSDTAMVQINIT----DANNYAPVFENAPYTASVFEDAPIGTT 487
+ L + A D G T+ ++ + AP F + Y + GT
Sbjct: 1095 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQ 1154
Query: 488 VLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGY 547
VL V A D G ITY L++E ++ F + PQ+G + LDRE Y
Sbjct: 1155 VLQVQAQAPDGG---PITYHLAAEGASSP-------FGLEPQSGWLWVRAALDREAQELY 1204
Query: 548 LLTVTARDGGVPSLSD---TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVG 604
+L V A G L T V +S+++ N++ P + + E+ GTSV +V
Sbjct: 1205 ILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVF 1264
Query: 605 ATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGT 664
ATD D G NGR+ Y L + +F I P +G + T + LDRE +++ L DGG+
Sbjct: 1265 ATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGS 1324
Query: 665 PPQSSTVIVHIKIEDINDSPPVF------ESDCLTFYISENSPIGTTIGEIRAHDPDEGP 718
PP+S+T VH+ + D+ND+ P F L + + P GT + ++A DPDEG
Sbjct: 1325 PPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGE 1384
Query: 719 NAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N + Y++ G S FSL G EL+T L + R Y L + A SPP
Sbjct: 1385 NGTILYTLT-GPGSELFSLHPHSG----ELLTAAPL-IRAERPHYVLTLSAHDQGSPP 1436
Score = 248 bits (607), Expect = 2e-64
Identities = 244/896 (27%), Positives = 399/896 (44%), Gaps = 78/896 (8%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
++ ++ + D ND+ P F ++Y AS+ + GT VL L+A D D G + + Y I
Sbjct: 805 VYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHI---L 861
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
A P +F +D +SG L L R + + + A D
Sbjct: 862 AGNSPP----------------LFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQ 905
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
++ +A + ++I+ P F + Y SV ED V + ++A + G +
Sbjct: 906 AE---PSARVDISIVPGTPTPPIFEQLQYVFSVPED--VAPGTSVGIVQAHNPP-GRLAP 959
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRS-YRLVIRAQDGGSPSRSNTTQLLI 245
+ ++ GG+ + FS+D++SG + ++ LD E + L +RA G P+ + ++ +
Sbjct: 960 VTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFA-VARVRV 1018
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
+ DVNDN+P F + N G I ++A D D GVN+ +T+T+ G
Sbjct: 1019 LLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTL----LAGGG 1074
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSA--TATXXXXXXXXXXXX 363
T+DP +G V L ++L + A DGG PPR++
Sbjct: 1075 G-AFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLA 1133
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLI 423
F Y V+L GT V+ + A A + + Y + F + Q+ G +
Sbjct: 1134 PRFNSPTYRVDLPSGTTAGTQVLQVQA-QAPDGGPITYHLAAEGASSPFGLEPQS--GWL 1190
Query: 424 TVAQPLDFKQERRYVLTV-----SATDSGGRSDTAMVQINITDANNYAPVFENAPYTASV 478
V LD + + Y+L V S + G ++ TA V+++I + N ++P P +V
Sbjct: 1191 WVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAV 1250
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GT+V V ATD D G N ++TYSL ++S ++ A F I+PQTG +TT +
Sbjct: 1251 AENQPPGTSVGRVFATDRDSGPNGRLTYSL-QQLSEDSKA-----FRIHPQTGEVTTLQT 1304
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA------NIME 592
LDRE S Y L V +DGG P S T V ++V+D+NDN P F Q A + +
Sbjct: 1305 LDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPD 1364
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVAT 652
GT V+ + A D D G NG I Y L E F + P SG + T L R
Sbjct: 1365 RVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSE--LFSLHPHSGELLTAAPLIRAERPH 1422
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKI---EDINDSPP-VFESD-------CLTFYISENSP 701
+ L A D G+PP+S+++ + +++ + + PP + E D LT +E
Sbjct: 1423 YVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLR 1482
Query: 702 IGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK 761
G+ +G + A +P G A+ + + G D +F+L+ G L LD+E+
Sbjct: 1483 PGSLLGSVAAPEP-AGVGALTYTLVGGADPEGTFALDAASG----RLYLARPLDFEAGPP 1537
Query: 762 KYELVIRAASPPLWND--VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L +RA P +RV++ V D N++AP + ++ P A
Sbjct: 1538 WRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRAS 1597
Query: 820 DAD---VTDKLQYRILSGN-NANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
DAD ++YR+L + L+ TG+++ L+ + V TD
Sbjct: 1598 DADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATD 1653
Score = 198 bits (483), Expect = 2e-49
Identities = 154/518 (29%), Positives = 240/518 (46%), Gaps = 23/518 (4%)
Query: 369 GQYEVELAEDEPPGTPVVTLTA-TDADEDNRLHYEITGGNTRG-RFSITSQNGRGLITVA 426
G ++++ E++P GT + ++A A L Y I+ G + G++ A
Sbjct: 181 GSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTA 240
Query: 427 QPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGT 486
+ LD +Q RY T D T V + + D N++AP F A V E GT
Sbjct: 241 RVLDREQRDRYRFTAVTPDGA----TVEVTVRVADINDHAPAFPQARAALQVPEHTAFGT 296
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
+ A D+D G Y+LS + + E + + LDRE S
Sbjct: 297 RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSH 356
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
Y+L + A DGG P ++++++D+ND+ P F Q Y A + E G+ V QV A+
Sbjct: 357 YMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFAS 416
Query: 607 DADVGLNGRIHYELDPKDRE-EGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G+NG + YE++ + E +G F ID +G+++ + LD E H+L A DGG
Sbjct: 417 DADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAH 476
Query: 666 PQSSTVIVHIKIEDINDSPP----VFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAV 721
P+ + V + + D ND+ P +F S + +SE +P G + I DPD+G A
Sbjct: 477 PELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAH 536
Query: 722 VHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDV 778
V+ S++GG+ F+L T Q S + LD E R Y L + A SPPL +
Sbjct: 537 VNVSLEGGE--GHFALST-QDSVIYLVCVARRLDREE-RDAYNLRVTATDSGSPPLRAEA 592
Query: 779 RVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFGRVPAYDAD--VTDKLQYRILSG 834
+ VTDVNDNAP D Q+ + P RV A D D ++ Y + G
Sbjct: 593 AFVLHVTDVNDNAPAF-DRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPG 651
Query: 835 NNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
+ + ++ T+G +T + L+ + + V TDG
Sbjct: 652 AHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDG 689
Score = 184 bits (447), Expect = 5e-45
Identities = 162/579 (27%), Positives = 250/579 (43%), Gaps = 45/579 (7%)
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E P G I + A G A L Y ++ ++ +G V + ID SG V T+ LD
Sbjct: 187 IDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSG-VGTDLAIDEHSGVVRTARVLD 244
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
RE + +Y+ DG AT F + +++ E GT
Sbjct: 245 REQRDRYRFTAVTPDG------ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRY 298
Query: 386 VTLTATDADED--NRLHYEITGGNTRGRFSITSQNGRG-----LITVAQPLDFKQERRYV 438
A DAD Y ++G F + ++ G + V LD + Y+
Sbjct: 299 PLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYM 358
Query: 439 LTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
L + A D G R A++ + + D N++AP F + Y A V E G+ VL V A+D+
Sbjct: 359 LQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDA 418
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
D G+N +TY + N + D F I+ TG + + LD E + L V ARDG
Sbjct: 419 DAGVNGAVTYEI-----NRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDG 473
Query: 557 GVPSLSDTTDVEISVVDVNDNEP----VFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
G + V + V D NDN+P +F + + E A G V+++ +D D G
Sbjct: 474 GAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGD 533
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIR---TNKALDRESVATHDLKAVAIDGGTPPQSS 669
++ L + EG F + VI + LDRE ++L+ A D G+PP +
Sbjct: 534 FAHVNVSL---EGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRA 590
Query: 670 TVIVHIKIEDINDSPPVFESDCL-TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKG 728
+ + D+ND+ P F+ + E + G+ + + A DPD+G N V YS+
Sbjct: 591 EAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAP 650
Query: 729 GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR--AASPPLWNDVRVEILVTD 786
G ++ FS++ G + T LDYE + +V+ PPL + V + + D
Sbjct: 651 GAHTHWFSIDPTSGI----ITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQD 706
Query: 787 VNDNAPVMKDFQIIFNNY---KDCFPVGPFGRVPAYDAD 822
VNDN P FQ F N + P F +V A DAD
Sbjct: 707 VNDNEP---QFQRTFYNASLPEGTQPGTCFLQVTATDAD 742
Score = 146 bits (354), Expect = 1e-33
Identities = 108/389 (27%), Positives = 175/389 (44%), Gaps = 16/389 (4%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGK-NAEVEYTIELV 65
+H Q+ D NDH+P F + Y +V E G+T+LTL+ATD D + +A V+Y+I +
Sbjct: 2604 VHVQLQ--DQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSI--I 2659
Query: 66 TADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASP 125
+ N + G L+ LD E + +Y + V A D+ P
Sbjct: 2660 SG---NWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP 2716
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
SS + V ++D NDN P F+ +Y V+V ED V + ++A+DAD G +
Sbjct: 2717 PQ---SSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPV--GAELLHVEASDADPGPHG 2771
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
+R+ + G+ F +D SG + L LD E ++LV++A D + + I
Sbjct: 2772 LVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAG-AHFALAPVTI 2830
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
++DVND+ P F +L SV+EN P G + + A D D G L Y++ +
Sbjct: 2831 EVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEG 2890
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++ +G + D E ++LLV A D G+ SA+ T
Sbjct: 2891 REAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPV 2948
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD 394
F+ + ++ E G + + ATD D
Sbjct: 2949 FLAPAFHFQVPEGARRGHSLGHVQATDED 2977
Score = 110 bits (265), Expect = 6e-23
Identities = 99/353 (28%), Positives = 157/353 (44%), Gaps = 39/353 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+ PVF Y +V E G +L ++A+D D G + V +T+ + D
Sbjct: 2726 VTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVS--SGDP- 2782
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+F +D SG L +LD E AR+ ++V+A D A
Sbjct: 2783 ----------------SGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHF--- 2823
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ A + + + D ND+ P F + SV E+ ++ + A D D GA +RY+
Sbjct: 2824 -ALAPVTIEVQDVNDHGPAFPLNLLSTSVAEN--QPPGTLVTTLHAIDGDAGAFGRLRYS 2880
Query: 191 II----GGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++ G + F+++S +G++ DYE S+RL++ A D G+ S S T +L+
Sbjct: 2881 LLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVT 2940
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM-TDKDYTG-- 303
D D P F F V E G+S+ VQA D D G + + Y++ T Y G
Sbjct: 2941 GEDEYD--PVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGIN 2998
Query: 304 --NVDLPITID---PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATAT 351
L + +D P SG + G +A +L + G P S +AT
Sbjct: 2999 QTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSAT 3051
>AB075518-1|BAE45762.1| 656|Homo sapiens putative protein product
of Nbla00548 protein.
Length = 656
Score = 309 bits (759), Expect = 8e-83
Identities = 206/669 (30%), Positives = 343/669 (51%), Gaps = 39/669 (5%)
Query: 86 VQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDND 145
+++ F I+ +G + + LDREKV+ Y + +K++D+ SP S++ + +NI+D+ND
Sbjct: 4 MENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQ---STSVKVMINILDEND 60
Query: 146 NYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSL 205
N P+FS+ ++ V E+ + + ++ +D D+G N+ RY+I+ + + F+I+
Sbjct: 61 NAPRFSQ-IFSAHVPENSPL--GYTVTRVTTSDEDIGINAISRYSIM--DASLPFTINPS 115
Query: 206 SGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
+GD+ + + L+ E YR+ + A D G + +T + I + D+NDNAPRF + +
Sbjct: 116 TGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSRTSYYLD 172
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTM-TDKDY------TGNVDLPITIDPRSGWV 318
E IG + +V A D DEG N ++ Y + + +Y TG + + ++
Sbjct: 173 CPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTG 232
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
+++ ++R + +VT++D G P + T F+ +Y + ++
Sbjct: 233 FSNVNINR-----HSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKN 287
Query: 379 EPPGTPVVTLTATDADE---DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQER 435
GT ++ +TA D + ++ + Y I+ N G+F + N G I+VA L +
Sbjct: 288 VKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKL--DNDTGWISVASSLISDLNQ 345
Query: 436 RYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSA 493
+ +TV+A D G S A V I +T+ N + P F + +A++ E IG+ V VSA
Sbjct: 346 NFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSA 405
Query: 494 TDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D D +N I YS+SS NE + F IN TG +T K LD E + +T++A
Sbjct: 406 RDRDAAMNGLIKYSISS--GNE-----EGIFAINSSTGILTLAKALDYELCQKHEMTISA 458
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
DGG + + V ++V+DVNDN PVF Y ++E+A GT+V + ATDAD G N
Sbjct: 459 IDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTN 518
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
I Y + D + FVIDP +GVI T LD E+ ++ L A + + S V
Sbjct: 519 AVIAYTVQSSDSD--LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATV 576
Query: 674 HIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSN 733
+I+++ N+ P F S F ISE +P GT +GE+ A D D G + VHY I G
Sbjct: 577 NIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKK 636
Query: 734 SFSLETRQG 742
F + + G
Sbjct: 637 GFQINKKTG 645
Score = 296 bits (727), Expect = 6e-79
Identities = 209/674 (31%), Positives = 338/674 (50%), Gaps = 40/674 (5%)
Query: 194 GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDN 253
GN + FSI+ +G++ V+ LD E+V Y L I++ D GSPS+S + +++INI D NDN
Sbjct: 2 GNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDN 61
Query: 254 APRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
APRF + +F V EN P+GY++ RV D D G+NA Y++ D LP TI+P
Sbjct: 62 APRF-SQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMD------ASLPFTINP 114
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G + S L+RE +Y++ V+A D G + + F Y +
Sbjct: 115 STGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSRTSYYL 171
Query: 374 ELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQN--GRGLITVAQPL 429
+ E G+ V + ATD DE + ++ Y I + R + T+ + ++
Sbjct: 172 DCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVT 231
Query: 430 DFKQER--RYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
F R+ V+++D G S V INI D+N+ AP F + Y V ++ +G
Sbjct: 232 GFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVG 291
Query: 486 TTVLVVSATDS-DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETM 544
T ++ V+A D D G+N+++ Y +S++ +H +F ++ TG I+ L +
Sbjct: 292 TKLIRVTAIDDKDFGLNSEVEYFISND-------NHLGKFKLDNDTGWISVASSLISDLN 344
Query: 545 SGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVG 604
+ +TVTA+D G P LS V I+V + N + P F Q +A I E +G+ V V
Sbjct: 345 QNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVS 404
Query: 605 ATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGT 664
A D D +NG I Y + EEG F I+ ++G++ KALD E H++ AIDGG
Sbjct: 405 ARDRDAAMNGLIKYSIS-SGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGW 463
Query: 665 PPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHY 724
++ V + + D+ND+ PVF SD + EN+P GTT+ + A D D G NAV+ Y
Sbjct: 464 VARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAY 523
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPP---LWNDVRVE 781
+++ DS+ F ++ G + T LD+E+ ++ Y L ++A + P + V
Sbjct: 524 TVQ-SSDSDLFVIDPNTG----VITTQGFLDFET-KQSYHLTVKAFNVPDEERCSFATVN 577
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADV-TD-KLQYRILSGNNAN 838
I + N+ P ++ + + P G G V A D D+ TD ++ Y I +
Sbjct: 578 IQLKGTNEYVPRFVS-KLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKK 636
Query: 839 LILLNETTGSMTLS 852
+N+ TG + +S
Sbjct: 637 GFQINKKTGQIYVS 650
Score = 287 bits (704), Expect = 4e-76
Identities = 210/651 (32%), Positives = 324/651 (49%), Gaps = 60/651 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
IN+LD ND++P F Q + A V E + G TV + +D+DIG NA Y+I D
Sbjct: 53 INILDENDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSI----MDAS 107
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F I+ +G ++ L+RE RY + V A D V
Sbjct: 108 LP-----------------FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTV---- 146
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+ TI V D NDN P+FS +Y + E + + ++ ATD D G+N + Y
Sbjct: 147 STDVTIFVT--DINDNAPRFSRTSYYLDCPELTEIGSK--VTQVFATDPDEGSNGQVFYF 202
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSY--------RLVIRAQDGGSPSRSNTTQ 242
I + F I++ +G++ + L Y+ V + ++ + D G PS + T
Sbjct: 203 I--KSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETT 260
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAY-DADEGVNAELTYTMTDKDY 301
+ INI D NDNAP+F S + V++NV +G ++RV A D D G+N+E+ Y +++ ++
Sbjct: 261 VTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNH 320
Query: 302 TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
G L D +GW+ + L + + + VTA D G+PP S+ AT
Sbjct: 321 LGKFKL----DNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENY 376
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E G+ V T++A D D + + Y I+ GN G F+I S
Sbjct: 377 HTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSST- 435
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T+A+ LD++ +++ +T+SA D G R+ V +N+ D N+ +PVF + Y +
Sbjct: 436 -GILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPT 494
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+AP GTTV+ ++ATD+D G NA I Y++ S S+ FVI+P TG ITT
Sbjct: 495 VLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD--------LFVIDPNTGVITTQG 546
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LD ET Y LTV A + V I + N+ P F +LY I E A G
Sbjct: 547 FLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKG 606
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
T V +V A+D D+G +G +HY + R++G F I+ +G I + LD++
Sbjct: 607 TIVGEVFASDRDLGTDGEVHYLIFGNSRKKG-FQINKKTGQIYVSGILDQK 656
Score = 185 bits (450), Expect = 2e-45
Identities = 150/484 (30%), Positives = 227/484 (46%), Gaps = 41/484 (8%)
Query: 406 GNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDAN 463
GN FSI G I +PLD ++ YVLT+ ++D G +S + V INI D N
Sbjct: 2 GNMENSFSINHATGE--IRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDEN 59
Query: 464 NYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQ 523
+ AP F ++A V E++P+G TV V+ +D D+GINA IS ++
Sbjct: 60 DNAPRFSQI-FSAHVPENSPLGYTVTRVTTSDEDIGINA---------ISRYSIMDASLP 109
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ 583
F INP TG I ++ L+RE Y + V+A D G + +TDV I V D+NDN P F +
Sbjct: 110 FTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSR 166
Query: 584 QLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNK 643
Y + E +G+ V+QV ATD D G NG++ Y + K + E F I+ +G I +
Sbjct: 167 TSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFI--KSQSE-YFRINATTGEIFNKQ 223
Query: 644 ALDRESVA--------THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFY 695
L ++V H + D G P S V I I D ND+ P F
Sbjct: 224 ILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTP 283
Query: 696 ISENSPIGTTIGEIRA-HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
+++N +GT + + A D D G N+ V Y I + F L+ G + DL
Sbjct: 284 VTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDL 343
Query: 755 DYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
+ + + + + A +PPL + V I VT+ N + P + + +G
Sbjct: 344 N-----QNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSAT-IPESHSIG 397
Query: 812 PFGR-VPAYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVS 868
R V A D D + ++Y I SGN + +N +TG +TL+ L+ + + M +S
Sbjct: 398 SIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTIS 457
Query: 869 VTDG 872
DG
Sbjct: 458 AIDG 461
>AL772287-1|CAI13625.2| 1066|Homo sapiens cadherin-like 23 protein.
Length = 1066
Score = 301 bits (738), Expect = 3e-80
Identities = 254/827 (30%), Positives = 386/827 (46%), Gaps = 84/827 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I + D D P+F Y ++ E + GTTV + A DQD G+ + YTI V +T
Sbjct: 229 IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNT- 287
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVAR---YTVLVKAT---DQAS 124
+F +D SG L LDRE + + VK T D +
Sbjct: 288 ----------------NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 331
Query: 125 PVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGAN 184
P SD + T T ++ +ID NDN P+F+ Y+V++ E ++ + I+ D D G N
Sbjct: 332 P-SDA-TVTTTFNILVIDINDNAPEFNSSEYSVAITE-LAQVGFALPLFIQVVDKDEGLN 388
Query: 185 SAIRYAIIGGNTQ-MQFSIDSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
S ++G N+ S S+ G + + LDYE V Y + A + P
Sbjct: 389 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVG 447
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
++ I + + NDN P F L+ S+ ENV +G S++ V A D D G E++Y +D
Sbjct: 448 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD 507
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
++D +G + +LD E ++ L + A DGG T
Sbjct: 508 PDR------FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLDV 559
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGR-FSITS 416
F Y L E+EP T +V L ATD D +N++ Y I + G F I+
Sbjct: 560 NDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISL 619
Query: 417 QNGRGLITVAQPLDFKQERRYV--LTVSATDSGGR--SDTAMVQINITDANNYAPVFENA 472
G G+I+V++PLD++Q + LTV A D+G + T V I + D N+ P F
Sbjct: 620 YEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP 679
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH---DQQFVINPQ 529
Y SV E+ G TVL ++ATD D S E E++ + QF IN +
Sbjct: 680 AYFVSVVENIMAGATVLFLNATDLD----------RSREYGQESIIYSLEGSTQFRINAR 729
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT--TDVEISVVDVNDNEPVFKQQLYT 587
+G ITT LLDRET S Y+L V A DGGV T V I+++D+NDN P +K Y
Sbjct: 730 SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 789
Query: 588 ANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LD 646
N++E + V+ V A D D+G NG + Y + P ++ + ++ +G IRT A LD
Sbjct: 790 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK---FYSLNSTTGKIRTTHAMLD 846
Query: 647 RESVATHD---LKAVAI---DGGTPP--QSSTVIVHIKIEDINDSPPVFESDCLTFYISE 698
RE+ H+ ++ + + D G PP +S+ V + + D+ND+ P F++ + E
Sbjct: 847 RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 906
Query: 699 NSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES 758
P G +I ++ A D DEG N +V Y + G F + + G +VT +LD E
Sbjct: 907 GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG----VVVTTTELDRER 962
Query: 759 PRKKYELVI---RAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
+Y+L + A +P + + I V DVND P F ++N
Sbjct: 963 -IAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF--FPAVYN 1006
Score = 289 bits (708), Expect = 1e-76
Identities = 223/737 (30%), Positives = 355/737 (48%), Gaps = 57/737 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV-LTLKATDQDIGKNAEVEYTIELVTADT 69
I V+D ND++P F +Y ++ E A G + L ++ D+D G N+ E + LV ++
Sbjct: 343 ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFE--VYLVGNNS 400
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRA-SLDREKVARYTVLVKATDQASPVSD 128
+ + + G++ + A LD E V RY + A + V D
Sbjct: 401 HH-------------FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES---VPD 444
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ A + + +I++NDN P FS+ Y +S+ E+++V + + + ATD D G +
Sbjct: 445 HVGY-AKVKITLINENDNRPIFSQPLYNISLYENVTVGTS--VLTVLATDNDAGTFGEVS 501
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y + +FS+D +G + L+ LDYE ++ + L I A+DGG T ++ IN+
Sbjct: 502 YFF--SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVL 557
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F + ++ EN P +VR++A D D N ++TY++ G+
Sbjct: 558 DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY-FD 616
Query: 309 ITIDPRSGWVYTSGQLDRE--TQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I++ G + S LD E + L V A D G+PP ++T F
Sbjct: 617 ISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTF 676
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG--RFSITSQNGRGLIT 424
Y V + E+ G V+ L ATD D E + G +F I +++G IT
Sbjct: 677 SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGE--IT 734
Query: 425 VAQPLDFKQERRYVLTVSATDSG-GRSD-TAMVQINIT--DANNYAPVFENAPYTASVFE 480
LD + + Y+L V A D G G + T + +NIT D N+ P +++APY ++ E
Sbjct: 735 TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVE 794
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAI-TTNKLL 539
P + V V A D D+G N + YS+ ++ + +N TG I TT+ +L
Sbjct: 795 MTPPDSDVTTVVAVDPDLGENGTLVYSIQPP---------NKFYSLNSTTGKIRTTHAML 845
Query: 540 DRETMSGY------LLTVTARDGGVPSLSDTTD--VEISVVDVNDNEPVFKQQLYTANIM 591
DRE + + V+ D G P L T+ V ++++D+NDN+P F+ + A ++
Sbjct: 846 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 905
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVA 651
E G S+ QV A D D GLNG + Y + P F+I+ +SGV+ T LDRE +A
Sbjct: 906 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGMPRMDFLINSSSGVVVTTTELDRERIA 964
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
+ L+ VA D GTP +SST + I + D+ND P F +SE+ P + +
Sbjct: 965 EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1024
Query: 712 HDPDEGPNAVVHYSIKG 728
D D G NA + Y I G
Sbjct: 1025 TDNDVGLNAELSYFITG 1041
Score = 271 bits (664), Expect = 3e-71
Identities = 254/874 (29%), Positives = 394/874 (45%), Gaps = 82/874 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPV---IAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
F + Y+V + E + + PV I + ATD D+GA ++ Y+ F+IDS
Sbjct: 132 FHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSAR 189
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQES 265
G V++++ LDYE ++Y+L + A D +T L I I DV D P F + +
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTN 249
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E+ P G ++ + A D D+G + YT+ GN + +D SG + +G LD
Sbjct: 250 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVS--VAGNTNSIFALDYISGVLTLNGLLD 307
Query: 326 RETQAK---YQLLVTATDGGDP--PRSATATXXXXXXXXXXXXXX--FMPGQYEVELAED 378
RE + L V T+ D P AT T F +Y V + E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 379 EPPGTPV-VTLTATDADEDNRLHYEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFK 432
G + + + D DE +E+ GN F I TS G+ I VA PLD++
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 427
Query: 433 QERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVV 491
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 428 TVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 487
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 488 LATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTI 538
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 539 IARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP 596
Query: 612 LNGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQ 667
N +I Y + F I GVI ++ LD E ++ L +A+D G PP
Sbjct: 597 PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL 656
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVH 723
+STV V I++ D ND+PP F + EN G T+ + A D D G +++
Sbjct: 657 NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII- 715
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR---- 779
YS++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 716 YSLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIA 767
Query: 780 -VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNN 836
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 768 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN- 826
Query: 837 ANLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLIT 888
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 827 -KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV---- 881
Query: 889 EEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 882 ---FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 910
Score = 267 bits (655), Expect = 3e-70
Identities = 252/881 (28%), Positives = 393/881 (44%), Gaps = 76/881 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVRE-GASS----GTTVLTLKATDQDIGKNAEVEYTIELV 65
I V D ND++P F Q Y + E GA+ GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ-- 177
Query: 66 TADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASP 125
P F ID G + LD E Y + V ATDQ
Sbjct: 178 ------PP-------------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK- 217
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ LS+ A + + I D D P F Y+ ++ E + I A D D G
Sbjct: 218 -TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE--HSPPGTTVRIITAIDQDKGRPR 274
Query: 186 AIRYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSR 237
I Y I + GNT F++D +SG ++L LD E + S+ ++ + D +PS
Sbjct: 275 GIGYTIVSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 334
Query: 238 SN-TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADEGVNAELTYT 295
+ TT I + D+NDNAP F +S + +++E +G+++ + +Q D DEG+N+
Sbjct: 335 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVY 394
Query: 296 MTDKDYTGNVDLPITIDPRSG-WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ + + P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKI 453
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSI 414
F Y + L E+ GT V+T+ ATD D + RFS+
Sbjct: 454 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSL 513
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPY 474
GLI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y
Sbjct: 514 DKDT--GLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
++ E+ P T ++ + ATD D N QITYS+ +S A + + G I+
Sbjct: 572 VGALRENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVIS 627
Query: 535 TNKLLDRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
++ LD E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E
Sbjct: 628 VSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVE 687
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESV 650
+ + G +V + ATD D R + + EGS F I+ SG I T LDRE+
Sbjct: 688 NIMAGATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETK 744
Query: 651 ATHDLKAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
+ + L A+DGG T I V+I + DIND+ P ++ + E +P + +
Sbjct: 745 SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTT 804
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------R 760
+ A DPD G N + YSI+ + +SL + G + T LD E+P R
Sbjct: 805 VVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMR 859
Query: 761 KKYELVIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVP 817
K V PPL + V + + D+NDN P ++ + + P G +V
Sbjct: 860 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVV 918
Query: 818 AYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
A D D + + YR+ G L+N ++G + + +L+
Sbjct: 919 AIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 959
Score = 261 bits (639), Expect = 3e-68
Identities = 190/628 (30%), Positives = 294/628 (46%), Gaps = 61/628 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 452 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 505
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 506 ---DD------------PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 546
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 547 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 602
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 603 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 662
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 663 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSL 718
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DG G ++ AT
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTG 836
Query: 420 R-----GLITVAQPLDFKQERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFE 470
+ ++ P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 837 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 896
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 897 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSS 949
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 950 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1009
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHY 618
ED V + TD DVGLN + Y
Sbjct: 1010 SEDVPREFRVVWLNCTDNDVGLNAELSY 1037
Score = 188 bits (458), Expect = 3e-46
Identities = 150/512 (29%), Positives = 235/512 (45%), Gaps = 36/512 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 553 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 610
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTV--LVKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 611 FG-------------SYFDISLYEG-YGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-- 654
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 655 -PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 711
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 712 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 771
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM--TDKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 772 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 831
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 832 N-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 890
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +
Sbjct: 891 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS- 949
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 950 -GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1008
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLS 509
V ED P V+ ++ TD+DVG+NA+++Y ++
Sbjct: 1009 VSEDVPREFRVVWLNCTDNDVGLNAELSYFIT 1040
Score = 179 bits (436), Expect = 1e-43
Identities = 166/569 (29%), Positives = 257/569 (45%), Gaps = 61/569 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ + ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRF----FAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + +D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAE-----DEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLI 423
+ E + P GTP+ + ATD D GG+ F SQ + RG++
Sbjct: 140 RIPEVGATGNTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIV 192
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFE 480
TV + LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E
Sbjct: 193 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+P GTTV +++A D D G I Y++ S N + F ++ +G +T N LLD
Sbjct: 253 HSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNT-----NSIFALDYISGVLTLNGLLD 307
Query: 541 RET---MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMED 593
RE G++LTV D PS + TT I V+D+NDN P F Y+ I E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 594 ALVGTSVSQ-VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALD 646
A VG ++ + D D GLN +E+ F+I P S IR LD
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 425
Query: 647 RESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E+V +D A + P V I + + ND+ P+F + EN +GT++
Sbjct: 426 YETVDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 484
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
+ A D D G V Y DD + FSL+ D ++ + LDYE ++ +
Sbjct: 485 LTVLATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTI 538
Query: 767 IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
I RV I V DVNDN P +
Sbjct: 539 IARDGGGEETTGRVRINVLDVNDNVPTFQ 567
>AL731541-5|CAM20296.1| 1066|Homo sapiens cadherin-like 23 protein.
Length = 1066
Score = 301 bits (738), Expect = 3e-80
Identities = 254/827 (30%), Positives = 386/827 (46%), Gaps = 84/827 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I + D D P+F Y ++ E + GTTV + A DQD G+ + YTI V +T
Sbjct: 229 IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNT- 287
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVAR---YTVLVKAT---DQAS 124
+F +D SG L LDRE + + VK T D +
Sbjct: 288 ----------------NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 331
Query: 125 PVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGAN 184
P SD + T T ++ +ID NDN P+F+ Y+V++ E ++ + I+ D D G N
Sbjct: 332 P-SDA-TVTTTFNILVIDINDNAPEFNSSEYSVAITE-LAQVGFALPLFIQVVDKDEGLN 388
Query: 185 SAIRYAIIGGNTQ-MQFSIDSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
S ++G N+ S S+ G + + LDYE V Y + A + P
Sbjct: 389 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVG 447
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
++ I + + NDN P F L+ S+ ENV +G S++ V A D D G E++Y +D
Sbjct: 448 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD 507
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
++D +G + +LD E ++ L + A DGG T
Sbjct: 508 PDR------FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLDV 559
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGR-FSITS 416
F Y L E+EP T +V L ATD D +N++ Y I + G F I+
Sbjct: 560 NDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISL 619
Query: 417 QNGRGLITVAQPLDFKQERRYV--LTVSATDSGGR--SDTAMVQINITDANNYAPVFENA 472
G G+I+V++PLD++Q + LTV A D+G + T V I + D N+ P F
Sbjct: 620 YEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP 679
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH---DQQFVINPQ 529
Y SV E+ G TVL ++ATD D S E E++ + QF IN +
Sbjct: 680 AYFVSVVENIMAGATVLFLNATDLD----------RSREYGQESIIYSLEGSTQFRINAR 729
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT--TDVEISVVDVNDNEPVFKQQLYT 587
+G ITT LLDRET S Y+L V A DGGV T V I+++D+NDN P +K Y
Sbjct: 730 SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 789
Query: 588 ANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LD 646
N++E + V+ V A D D+G NG + Y + P ++ + ++ +G IRT A LD
Sbjct: 790 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK---FYSLNSTTGKIRTTHAMLD 846
Query: 647 RESVATHD---LKAVAI---DGGTPP--QSSTVIVHIKIEDINDSPPVFESDCLTFYISE 698
RE+ H+ ++ + + D G PP +S+ V + + D+ND+ P F++ + E
Sbjct: 847 RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 906
Query: 699 NSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES 758
P G +I ++ A D DEG N +V Y + G F + + G +VT +LD E
Sbjct: 907 GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG----VVVTTTELDRER 962
Query: 759 PRKKYELVI---RAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
+Y+L + A +P + + I V DVND P F ++N
Sbjct: 963 -IAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF--FPAVYN 1006
Score = 289 bits (708), Expect = 1e-76
Identities = 223/737 (30%), Positives = 355/737 (48%), Gaps = 57/737 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV-LTLKATDQDIGKNAEVEYTIELVTADT 69
I V+D ND++P F +Y ++ E A G + L ++ D+D G N+ E + LV ++
Sbjct: 343 ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFE--VYLVGNNS 400
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRA-SLDREKVARYTVLVKATDQASPVSD 128
+ + + G++ + A LD E V RY + A + V D
Sbjct: 401 HH-------------FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES---VPD 444
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ A + + +I++NDN P FS+ Y +S+ E+++V + + + ATD D G +
Sbjct: 445 HVGY-AKVKITLINENDNRPIFSQPLYNISLYENVTVGTS--VLTVLATDNDAGTFGEVS 501
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y + +FS+D +G + L+ LDYE ++ + L I A+DGG T ++ IN+
Sbjct: 502 YFF--SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVL 557
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F + ++ EN P +VR++A D D N ++TY++ G+
Sbjct: 558 DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY-FD 616
Query: 309 ITIDPRSGWVYTSGQLDRE--TQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I++ G + S LD E + L V A D G+PP ++T F
Sbjct: 617 ISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTF 676
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG--RFSITSQNGRGLIT 424
Y V + E+ G V+ L ATD D E + G +F I +++G IT
Sbjct: 677 SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGE--IT 734
Query: 425 VAQPLDFKQERRYVLTVSATDSG-GRSD-TAMVQINIT--DANNYAPVFENAPYTASVFE 480
LD + + Y+L V A D G G + T + +NIT D N+ P +++APY ++ E
Sbjct: 735 TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVE 794
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAI-TTNKLL 539
P + V V A D D+G N + YS+ ++ + +N TG I TT+ +L
Sbjct: 795 MTPPDSDVTTVVAVDPDLGENGTLVYSIQPP---------NKFYSLNSTTGKIRTTHAML 845
Query: 540 DRETMSGY------LLTVTARDGGVPSLSDTTD--VEISVVDVNDNEPVFKQQLYTANIM 591
DRE + + V+ D G P L T+ V ++++D+NDN+P F+ + A ++
Sbjct: 846 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 905
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVA 651
E G S+ QV A D D GLNG + Y + P F+I+ +SGV+ T LDRE +A
Sbjct: 906 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGMPRMDFLINSSSGVVVTTTELDRERIA 964
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
+ L+ VA D GTP +SST + I + D+ND P F +SE+ P + +
Sbjct: 965 EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1024
Query: 712 HDPDEGPNAVVHYSIKG 728
D D G NA + Y I G
Sbjct: 1025 TDNDVGLNAELSYFITG 1041
Score = 271 bits (664), Expect = 3e-71
Identities = 254/874 (29%), Positives = 394/874 (45%), Gaps = 82/874 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPV---IAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
F + Y+V + E + + PV I + ATD D+GA ++ Y+ F+IDS
Sbjct: 132 FHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSAR 189
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQES 265
G V++++ LDYE ++Y+L + A D +T L I I DV D P F + +
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTN 249
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E+ P G ++ + A D D+G + YT+ GN + +D SG + +G LD
Sbjct: 250 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVS--VAGNTNSIFALDYISGVLTLNGLLD 307
Query: 326 RETQAK---YQLLVTATDGGDP--PRSATATXXXXXXXXXXXXXX--FMPGQYEVELAED 378
RE + L V T+ D P AT T F +Y V + E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 379 EPPGTPV-VTLTATDADEDNRLHYEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFK 432
G + + + D DE +E+ GN F I TS G+ I VA PLD++
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 427
Query: 433 QERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVV 491
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 428 TVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 487
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 488 LATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTI 538
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 539 IARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP 596
Query: 612 LNGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQ 667
N +I Y + F I GVI ++ LD E ++ L +A+D G PP
Sbjct: 597 PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL 656
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVH 723
+STV V I++ D ND+PP F + EN G T+ + A D D G +++
Sbjct: 657 NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII- 715
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR---- 779
YS++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 716 YSLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIA 767
Query: 780 -VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNN 836
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 768 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN- 826
Query: 837 ANLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLIT 888
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 827 -KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV---- 881
Query: 889 EEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 882 ---FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 910
Score = 267 bits (655), Expect = 3e-70
Identities = 252/881 (28%), Positives = 393/881 (44%), Gaps = 76/881 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVRE-GASS----GTTVLTLKATDQDIGKNAEVEYTIELV 65
I V D ND++P F Q Y + E GA+ GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ-- 177
Query: 66 TADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASP 125
P F ID G + LD E Y + V ATDQ
Sbjct: 178 ------PP-------------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK- 217
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ LS+ A + + I D D P F Y+ ++ E + I A D D G
Sbjct: 218 -TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE--HSPPGTTVRIITAIDQDKGRPR 274
Query: 186 AIRYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSR 237
I Y I + GNT F++D +SG ++L LD E + S+ ++ + D +PS
Sbjct: 275 GIGYTIVSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 334
Query: 238 SN-TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADEGVNAELTYT 295
+ TT I + D+NDNAP F +S + +++E +G+++ + +Q D DEG+N+
Sbjct: 335 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVY 394
Query: 296 MTDKDYTGNVDLPITIDPRSG-WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ + + P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKI 453
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSI 414
F Y + L E+ GT V+T+ ATD D + RFS+
Sbjct: 454 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSL 513
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPY 474
GLI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y
Sbjct: 514 DKDT--GLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
++ E+ P T ++ + ATD D N QITYS+ +S A + + G I+
Sbjct: 572 VGALRENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVIS 627
Query: 535 TNKLLDRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
++ LD E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E
Sbjct: 628 VSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVE 687
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESV 650
+ + G +V + ATD D R + + EGS F I+ SG I T LDRE+
Sbjct: 688 NIMAGATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETK 744
Query: 651 ATHDLKAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
+ + L A+DGG T I V+I + DIND+ P ++ + E +P + +
Sbjct: 745 SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTT 804
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------R 760
+ A DPD G N + YSI+ + +SL + G + T LD E+P R
Sbjct: 805 VVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMR 859
Query: 761 KKYELVIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVP 817
K V PPL + V + + D+NDN P ++ + + P G +V
Sbjct: 860 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVV 918
Query: 818 AYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
A D D + + YR+ G L+N ++G + + +L+
Sbjct: 919 AIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 959
Score = 261 bits (639), Expect = 3e-68
Identities = 190/628 (30%), Positives = 294/628 (46%), Gaps = 61/628 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 452 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 505
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 506 ---DD------------PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 546
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 547 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 602
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 603 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 662
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 663 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSL 718
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DG G ++ AT
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTG 836
Query: 420 R-----GLITVAQPLDFKQERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFE 470
+ ++ P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 837 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 896
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 897 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSS 949
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 950 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1009
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHY 618
ED V + TD DVGLN + Y
Sbjct: 1010 SEDVPREFRVVWLNCTDNDVGLNAELSY 1037
Score = 188 bits (458), Expect = 3e-46
Identities = 150/512 (29%), Positives = 235/512 (45%), Gaps = 36/512 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 553 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 610
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTV--LVKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 611 FG-------------SYFDISLYEG-YGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-- 654
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 655 -PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 711
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 712 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 771
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM--TDKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 772 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 831
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 832 N-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 890
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +
Sbjct: 891 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS- 949
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 950 -GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1008
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLS 509
V ED P V+ ++ TD+DVG+NA+++Y ++
Sbjct: 1009 VSEDVPREFRVVWLNCTDNDVGLNAELSYFIT 1040
Score = 179 bits (436), Expect = 1e-43
Identities = 166/569 (29%), Positives = 257/569 (45%), Gaps = 61/569 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ + ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRF----FAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + +D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAE-----DEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLI 423
+ E + P GTP+ + ATD D GG+ F SQ + RG++
Sbjct: 140 RIPEVGATGNTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIV 192
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFE 480
TV + LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E
Sbjct: 193 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+P GTTV +++A D D G I Y++ S N + F ++ +G +T N LLD
Sbjct: 253 HSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNT-----NSIFALDYISGVLTLNGLLD 307
Query: 541 RET---MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMED 593
RE G++LTV D PS + TT I V+D+NDN P F Y+ I E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 594 ALVGTSVSQ-VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALD 646
A VG ++ + D D GLN +E+ F+I P S IR LD
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 425
Query: 647 RESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E+V +D A + P V I + + ND+ P+F + EN +GT++
Sbjct: 426 YETVDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 484
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
+ A D D G V Y DD + FSL+ D ++ + LDYE ++ +
Sbjct: 485 LTVLATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTI 538
Query: 767 IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
I RV I V DVNDN P +
Sbjct: 539 IARDGGGEETTGRVRINVLDVNDNVPTFQ 567
>AL359183-2|CAI13425.2| 1066|Homo sapiens cadherin-like 23 protein.
Length = 1066
Score = 301 bits (738), Expect = 3e-80
Identities = 254/827 (30%), Positives = 386/827 (46%), Gaps = 84/827 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I + D D P+F Y ++ E + GTTV + A DQD G+ + YTI V +T
Sbjct: 229 IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNT- 287
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVAR---YTVLVKAT---DQAS 124
+F +D SG L LDRE + + VK T D +
Sbjct: 288 ----------------NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 331
Query: 125 PVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGAN 184
P SD + T T ++ +ID NDN P+F+ Y+V++ E ++ + I+ D D G N
Sbjct: 332 P-SDA-TVTTTFNILVIDINDNAPEFNSSEYSVAITE-LAQVGFALPLFIQVVDKDEGLN 388
Query: 185 SAIRYAIIGGNTQ-MQFSIDSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
S ++G N+ S S+ G + + LDYE V Y + A + P
Sbjct: 389 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVG 447
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
++ I + + NDN P F L+ S+ ENV +G S++ V A D D G E++Y +D
Sbjct: 448 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD 507
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
++D +G + +LD E ++ L + A DGG T
Sbjct: 508 PDR------FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLDV 559
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGR-FSITS 416
F Y L E+EP T +V L ATD D +N++ Y I + G F I+
Sbjct: 560 NDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISL 619
Query: 417 QNGRGLITVAQPLDFKQERRYV--LTVSATDSGGR--SDTAMVQINITDANNYAPVFENA 472
G G+I+V++PLD++Q + LTV A D+G + T V I + D N+ P F
Sbjct: 620 YEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP 679
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH---DQQFVINPQ 529
Y SV E+ G TVL ++ATD D S E E++ + QF IN +
Sbjct: 680 AYFVSVVENIMAGATVLFLNATDLD----------RSREYGQESIIYSLEGSTQFRINAR 729
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT--TDVEISVVDVNDNEPVFKQQLYT 587
+G ITT LLDRET S Y+L V A DGGV T V I+++D+NDN P +K Y
Sbjct: 730 SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 789
Query: 588 ANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LD 646
N++E + V+ V A D D+G NG + Y + P ++ + ++ +G IRT A LD
Sbjct: 790 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK---FYSLNSTTGKIRTTHAMLD 846
Query: 647 RESVATHD---LKAVAI---DGGTPP--QSSTVIVHIKIEDINDSPPVFESDCLTFYISE 698
RE+ H+ ++ + + D G PP +S+ V + + D+ND+ P F++ + E
Sbjct: 847 RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 906
Query: 699 NSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES 758
P G +I ++ A D DEG N +V Y + G F + + G +VT +LD E
Sbjct: 907 GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG----VVVTTTELDRER 962
Query: 759 PRKKYELVI---RAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
+Y+L + A +P + + I V DVND P F ++N
Sbjct: 963 -IAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF--FPAVYN 1006
Score = 289 bits (708), Expect = 1e-76
Identities = 223/737 (30%), Positives = 355/737 (48%), Gaps = 57/737 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV-LTLKATDQDIGKNAEVEYTIELVTADT 69
I V+D ND++P F +Y ++ E A G + L ++ D+D G N+ E + LV ++
Sbjct: 343 ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFE--VYLVGNNS 400
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRA-SLDREKVARYTVLVKATDQASPVSD 128
+ + + G++ + A LD E V RY + A + V D
Sbjct: 401 HH-------------FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES---VPD 444
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ A + + +I++NDN P FS+ Y +S+ E+++V + + + ATD D G +
Sbjct: 445 HVGY-AKVKITLINENDNRPIFSQPLYNISLYENVTVGTS--VLTVLATDNDAGTFGEVS 501
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y + +FS+D +G + L+ LDYE ++ + L I A+DGG T ++ IN+
Sbjct: 502 YFF--SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVL 557
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F + ++ EN P +VR++A D D N ++TY++ G+
Sbjct: 558 DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY-FD 616
Query: 309 ITIDPRSGWVYTSGQLDRE--TQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I++ G + S LD E + L V A D G+PP ++T F
Sbjct: 617 ISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTF 676
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG--RFSITSQNGRGLIT 424
Y V + E+ G V+ L ATD D E + G +F I +++G IT
Sbjct: 677 SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGE--IT 734
Query: 425 VAQPLDFKQERRYVLTVSATDSG-GRSD-TAMVQINIT--DANNYAPVFENAPYTASVFE 480
LD + + Y+L V A D G G + T + +NIT D N+ P +++APY ++ E
Sbjct: 735 TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVE 794
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAI-TTNKLL 539
P + V V A D D+G N + YS+ ++ + +N TG I TT+ +L
Sbjct: 795 MTPPDSDVTTVVAVDPDLGENGTLVYSIQPP---------NKFYSLNSTTGKIRTTHAML 845
Query: 540 DRETMSGY------LLTVTARDGGVPSLSDTTD--VEISVVDVNDNEPVFKQQLYTANIM 591
DRE + + V+ D G P L T+ V ++++D+NDN+P F+ + A ++
Sbjct: 846 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 905
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVA 651
E G S+ QV A D D GLNG + Y + P F+I+ +SGV+ T LDRE +A
Sbjct: 906 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGMPRMDFLINSSSGVVVTTTELDRERIA 964
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
+ L+ VA D GTP +SST + I + D+ND P F +SE+ P + +
Sbjct: 965 EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1024
Query: 712 HDPDEGPNAVVHYSIKG 728
D D G NA + Y I G
Sbjct: 1025 TDNDVGLNAELSYFITG 1041
Score = 271 bits (664), Expect = 3e-71
Identities = 254/874 (29%), Positives = 394/874 (45%), Gaps = 82/874 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPV---IAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
F + Y+V + E + + PV I + ATD D+GA ++ Y+ F+IDS
Sbjct: 132 FHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSAR 189
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQES 265
G V++++ LDYE ++Y+L + A D +T L I I DV D P F + +
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTN 249
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E+ P G ++ + A D D+G + YT+ GN + +D SG + +G LD
Sbjct: 250 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVS--VAGNTNSIFALDYISGVLTLNGLLD 307
Query: 326 RETQAK---YQLLVTATDGGDP--PRSATATXXXXXXXXXXXXXX--FMPGQYEVELAED 378
RE + L V T+ D P AT T F +Y V + E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 379 EPPGTPV-VTLTATDADEDNRLHYEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFK 432
G + + + D DE +E+ GN F I TS G+ I VA PLD++
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 427
Query: 433 QERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVV 491
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 428 TVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 487
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 488 LATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTI 538
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 539 IARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP 596
Query: 612 LNGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQ 667
N +I Y + F I GVI ++ LD E ++ L +A+D G PP
Sbjct: 597 PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL 656
Query: 668 SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVH 723
+STV V I++ D ND+PP F + EN G T+ + A D D G +++
Sbjct: 657 NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII- 715
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR---- 779
YS++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 716 YSLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIA 767
Query: 780 -VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNN 836
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 768 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN- 826
Query: 837 ANLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLIT 888
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 827 -KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV---- 881
Query: 889 EEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 882 ---FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 910
Score = 267 bits (655), Expect = 3e-70
Identities = 252/881 (28%), Positives = 393/881 (44%), Gaps = 76/881 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVRE-GASS----GTTVLTLKATDQDIGKNAEVEYTIELV 65
I V D ND++P F Q Y + E GA+ GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ-- 177
Query: 66 TADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASP 125
P F ID G + LD E Y + V ATDQ
Sbjct: 178 ------PP-------------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK- 217
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
+ LS+ A + + I D D P F Y+ ++ E + I A D D G
Sbjct: 218 -TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE--HSPPGTTVRIITAIDQDKGRPR 274
Query: 186 AIRYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSR 237
I Y I + GNT F++D +SG ++L LD E + S+ ++ + D +PS
Sbjct: 275 GIGYTIVSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 334
Query: 238 SN-TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADEGVNAELTYT 295
+ TT I + D+NDNAP F +S + +++E +G+++ + +Q D DEG+N+
Sbjct: 335 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVY 394
Query: 296 MTDKDYTGNVDLPITIDPRSG-WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ + + P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKI 453
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSI 414
F Y + L E+ GT V+T+ ATD D + RFS+
Sbjct: 454 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSL 513
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPY 474
GLI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y
Sbjct: 514 DKDT--GLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
++ E+ P T ++ + ATD D N QITYS+ +S A + + G I+
Sbjct: 572 VGALRENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVIS 627
Query: 535 TNKLLDRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
++ LD E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E
Sbjct: 628 VSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVE 687
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESV 650
+ + G +V + ATD D R + + EGS F I+ SG I T LDRE+
Sbjct: 688 NIMAGATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETK 744
Query: 651 ATHDLKAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
+ + L A+DGG T I V+I + DIND+ P ++ + E +P + +
Sbjct: 745 SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTT 804
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------R 760
+ A DPD G N + YSI+ + +SL + G + T LD E+P R
Sbjct: 805 VVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMR 859
Query: 761 KKYELVIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVP 817
K V PPL + V + + D+NDN P ++ + + P G +V
Sbjct: 860 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVV 918
Query: 818 AYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
A D D + + YR+ G L+N ++G + + +L+
Sbjct: 919 AIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 959
Score = 261 bits (639), Expect = 3e-68
Identities = 190/628 (30%), Positives = 294/628 (46%), Gaps = 61/628 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 452 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 505
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 506 ---DD------------PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 546
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 547 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 602
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 603 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 662
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 663 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSL 718
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DG G ++ AT
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTG 836
Query: 420 R-----GLITVAQPLDFKQERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFE 470
+ ++ P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 837 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 896
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 897 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSS 949
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 950 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1009
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHY 618
ED V + TD DVGLN + Y
Sbjct: 1010 SEDVPREFRVVWLNCTDNDVGLNAELSY 1037
Score = 188 bits (458), Expect = 3e-46
Identities = 150/512 (29%), Positives = 235/512 (45%), Gaps = 36/512 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 553 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 610
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTV--LVKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 611 FG-------------SYFDISLYEG-YGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-- 654
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 655 -PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 711
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 712 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 771
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM--TDKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 772 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 831
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 832 N-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 890
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +
Sbjct: 891 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS- 949
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 950 -GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1008
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLS 509
V ED P V+ ++ TD+DVG+NA+++Y ++
Sbjct: 1009 VSEDVPREFRVVWLNCTDNDVGLNAELSYFIT 1040
Score = 179 bits (436), Expect = 1e-43
Identities = 166/569 (29%), Positives = 257/569 (45%), Gaps = 61/569 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ + ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRF----FAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + +D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAE-----DEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLI 423
+ E + P GTP+ + ATD D GG+ F SQ + RG++
Sbjct: 140 RIPEVGATGNTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIV 192
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFE 480
TV + LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E
Sbjct: 193 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+P GTTV +++A D D G I Y++ S N + F ++ +G +T N LLD
Sbjct: 253 HSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNT-----NSIFALDYISGVLTLNGLLD 307
Query: 541 RET---MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMED 593
RE G++LTV D PS + TT I V+D+NDN P F Y+ I E
Sbjct: 308 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 367
Query: 594 ALVGTSVSQ-VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALD 646
A VG ++ + D D GLN +E+ F+I P S IR LD
Sbjct: 368 AQVGFALPLFIQVVDKDEGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 425
Query: 647 RESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E+V +D A + P V I + + ND+ P+F + EN +GT++
Sbjct: 426 YETVDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 484
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
+ A D D G V Y DD + FSL+ D ++ + LDYE ++ +
Sbjct: 485 LTVLATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTI 538
Query: 767 IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
I RV I V DVNDN P +
Sbjct: 539 IARDGGGEETTGRVRINVLDVNDNVPTFQ 567
>BC032581-1|AAH32581.1| 1061|Homo sapiens CDH23 protein protein.
Length = 1061
Score = 298 bits (731), Expect = 2e-79
Identities = 254/828 (30%), Positives = 388/828 (46%), Gaps = 86/828 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I + D D P+F Y ++ E + GTTV + A DQD G+ + YTI V+ +T
Sbjct: 224 IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI--VSGNT- 280
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVAR---YTVLVKAT---DQAS 124
+F +D SG L LDRE + + VK T D +
Sbjct: 281 ----------------NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
Query: 125 PVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PVIAKIKATDADVGA 183
P SD + T T ++ +ID NDN P+F+ Y+V++ E V P+ ++ D ++G
Sbjct: 325 P-SDA-TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
Query: 184 NSAIRYAIIGGNTQ-MQFSIDSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRS 238
NS ++G N+ S S+ G + + LDYE V Y + A + P
Sbjct: 383 NSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHV 441
Query: 239 NTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD 298
++ I + + NDN P F L+ S+ ENV +G S++ V A D D G E++Y +D
Sbjct: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
Query: 299 KDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX 358
++D +G + +LD E ++ L + A DGG T
Sbjct: 502 DPDR------FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLD 553
Query: 359 XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGR-FSIT 415
F Y L E+EP T +V L ATD D +N++ Y I + G F I+
Sbjct: 554 VNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS 613
Query: 416 SQNGRGLITVAQPLDFKQERRYV--LTVSATDSGGR--SDTAMVQINITDANNYAPVFEN 471
G G+I+V++PLD++Q + LTV A D+G + T V I + D N+ P F
Sbjct: 614 LYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSK 673
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH---DQQFVINP 528
Y SV E+ G TVL ++ATD D S E E++ + QF IN
Sbjct: 674 PAYFVSVVENIMAGATVLFLNATDLD----------RSREYGQESIIYSLEGSTQFRINA 723
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT--TDVEISVVDVNDNEPVFKQQLY 586
++G ITT LLDRET S Y+L V A DGGV T V I+++D+NDN P +K Y
Sbjct: 724 RSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPY 783
Query: 587 TANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-L 645
N++E + V+ V A D D+G NG + Y + P ++ + ++ +G IRT A L
Sbjct: 784 YINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK---FYSLNSTTGKIRTTHAML 840
Query: 646 DRESVATHD---LKAVAI---DGGTPP--QSSTVIVHIKIEDINDSPPVFESDCLTFYIS 697
DRE+ H+ ++ + + D G PP +S+ V + + D+ND+ P F++ +
Sbjct: 841 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 900
Query: 698 ENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYE 757
E P G +I ++ A D DEG N +V Y + G F + + G +VT +LD E
Sbjct: 901 EGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG----VVVTTTELDRE 956
Query: 758 SPRKKYELVI---RAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
+Y+L + A +P + + I V DVND P F ++N
Sbjct: 957 R-IAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF--FPAVYN 1001
Score = 287 bits (703), Expect = 5e-76
Identities = 220/737 (29%), Positives = 352/737 (47%), Gaps = 55/737 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV-LTLKATDQDIGKNAEVEYTIELVTADT 69
I V+D ND++P F +Y ++ E A G + L ++ D+D + + LV ++
Sbjct: 336 ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS 395
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRA-SLDREKVARYTVLVKATDQASPVSD 128
+ + + G++ + A LD E V RY + A + V D
Sbjct: 396 HH-------------FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES---VPD 439
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ A + + +I++NDN P FS+ Y +S+ E+++V + + + ATD D G +
Sbjct: 440 HVGY-AKVKITLINENDNRPIFSQPLYNISLYENVTVGTS--VLTVLATDNDAGTFGEVS 496
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y + +FS+D +G + L+ LDYE ++ + L I A+DGG T ++ IN+
Sbjct: 497 YFF--SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVL 552
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F + ++ EN P +VR++A D D N ++TY++ G+
Sbjct: 553 DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY-FD 611
Query: 309 ITIDPRSGWVYTSGQLDRE--TQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I++ G + S LD E + L V A D G+PP ++T F
Sbjct: 612 ISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTF 671
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG--RFSITSQNGRGLIT 424
Y V + E+ G V+ L ATD D E + G +F I +++G IT
Sbjct: 672 SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGE--IT 729
Query: 425 VAQPLDFKQERRYVLTVSATDSG-GRSD-TAMVQINIT--DANNYAPVFENAPYTASVFE 480
LD + + Y+L V A D G G + T + +NIT D N+ P +++APY ++ E
Sbjct: 730 TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVE 789
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAI-TTNKLL 539
P + V V A D D+G N + YS+ ++ + +N TG I TT+ +L
Sbjct: 790 MTPPDSDVTTVVAVDPDLGENGTLVYSIQPP---------NKFYSLNSTTGKIRTTHAML 840
Query: 540 DRETMSGY------LLTVTARDGGVPSLSDTTD--VEISVVDVNDNEPVFKQQLYTANIM 591
DRE + + V+ D G P L T+ V ++++D+NDN+P F+ + A ++
Sbjct: 841 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 900
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVA 651
E G S+ QV A D D GLNG + Y + P F+I+ +SGV+ T LDRE +A
Sbjct: 901 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGMPRMDFLINSSSGVVVTTTELDRERIA 959
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
+ L+ VA D GTP +SST + I + D+ND P F +SE+ P + +
Sbjct: 960 EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
Query: 712 HDPDEGPNAVVHYSIKG 728
D D G NA + Y I G
Sbjct: 1020 TDNDVGLNAELSYFITG 1036
Score = 273 bits (669), Expect = 7e-72
Identities = 250/876 (28%), Positives = 390/876 (44%), Gaps = 71/876 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND++P F Q Y + E GT + + ATD D+G V Y+ +
Sbjct: 120 IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ------- 172
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F ID G + LD E Y + V ATDQ + L
Sbjct: 173 -PP-------------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK--TRPL 216
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S+ A + + I D D P F Y+ ++ E + I A D D G I Y
Sbjct: 217 STLANLAIIITDVQDMDPIFINLPYSTNIYE--HSPPGTTVRIITAIDQDKGRPRGIGYT 274
Query: 191 IIGGNTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQ-----DGGSPSRSN-TTQL 243
I+ GNT F++D +SG ++L LD E + S+ ++ + D +PS + TT
Sbjct: 275 IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADE--GVNAELTYTMTDKD 300
I + D+NDNAP F +S + +++E +G+++ + +Q D DE G+N+ + +
Sbjct: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
Query: 301 YTGNVDLPITIDPRSG-WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ P ++ ++ + + LD ET +Y + A + P A
Sbjct: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINE 453
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F Y + L E+ GT V+T+ ATD D + RFS+
Sbjct: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDT- 512
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVF 479
GLI + LD++ +R+ LT+ A D GG T V+IN+ D N+ P F+ Y ++
Sbjct: 513 -GLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALR 571
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P T ++ + ATD D N QITYS+ +S A + + G I+ ++ L
Sbjct: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSI---VSASAFGSY-FDISLYEGYGVISVSRPL 627
Query: 540 DRETMSGYL--LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
D E +S L LTV A D G P L+ T V I V D NDN P F + Y +++E+ + G
Sbjct: 628 DYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAG 687
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGS--FVIDPASGVIRTNKALDRESVATHDL 655
+V + ATD D R + + EGS F I+ SG I T LDRE+ + + L
Sbjct: 688 ATVLFLNATDLD---RSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYIL 744
Query: 656 KAVAIDGGTPPQSSTVI--VHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
A+DGG T I V+I + DIND+ P ++ + E +P + + + A D
Sbjct: 745 IVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVD 804
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP--------RKKYEL 765
PD G N + YSI+ + +SL + G + T LD E+P RK
Sbjct: 805 PDLGENGTLVYSIQ--PPNKFYSLNSTTGKIR---TTHAMLDRENPDPHEAELMRKIVVS 859
Query: 766 VIRAASPPL--WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG-PFGRVPAYDAD 822
V PPL + V + + D+NDN P ++ + + P G +V A D D
Sbjct: 860 VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV-AEVLEGIPAGVSIYQVVAIDLD 918
Query: 823 --VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
+ + YR+ G L+N ++G + + +L+
Sbjct: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
Score = 269 bits (659), Expect = 1e-70
Identities = 254/873 (29%), Positives = 397/873 (45%), Gaps = 85/873 (9%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ++ +G + R LDRE + +TV +D + T +++ + D NDN P
Sbjct: 78 FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI------TRKVNIQVGDVNDNAPT 131
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDV 209
F + Y+V + E+ V P+ + ATD D+GA ++ Y+ F+IDS G V
Sbjct: 132 FHNQPYSVRIPENTPV-GTPIFI-VNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIV 187
Query: 210 SLVKTLDYEQVRSYRLVIRAQDGGSPSRSNT-TQLLINIRDVNDNAPRFYTSLFQESVSE 268
++++ LDYE ++Y+L + A D +T L I I DV D P F + ++ E
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 247
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRET 328
+ P G ++ + A D D+G + YT+ +GN + +D SG + +G LDRE
Sbjct: 248 HSPPGTTVRIITAIDQDKGRPRGIGYTIV----SGNTNSIFALDYISGVLTLNGLLDREN 303
Query: 329 QAK---YQLLVTATDGGDP--PRSATATXXXXXXXXXXXXXX--FMPGQYEVELAEDEPP 381
+ L V T+ D P AT T F +Y V + E
Sbjct: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQV 363
Query: 382 GTPV-VTLTATDADEDNRLH--YEI-TGGNTRGRFSI--TSQNGRG--LITVAQPLDFKQ 433
G + + + D DE+ L+ +E+ GN F I TS G+ I VA PLD++
Sbjct: 364 GFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET 423
Query: 434 ERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVS 492
RY + A +S A V+I + + N+ P+F Y S++E+ +GT+VL V
Sbjct: 424 VDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 484 ATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTII 534
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 535 ARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP 592
Query: 613 NGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQS 668
N +I Y + F I GVI ++ LD E ++ L +A+D G PP +
Sbjct: 593 NNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLN 652
Query: 669 STVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVHY 724
STV V I++ D ND+PP F + EN G T+ + A D D G +++ Y
Sbjct: 653 STVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-Y 711
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR----- 779
S++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 712 SLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIAT 763
Query: 780 VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNNA 837
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 764 VNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-- 821
Query: 838 NLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 822 KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV----- 876
Query: 890 EMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 877 --FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 905
Score = 261 bits (639), Expect = 3e-68
Identities = 190/628 (30%), Positives = 294/628 (46%), Gaps = 61/628 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS------ 500
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 501 ---DD------------PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 541
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 542 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 597
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 598 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 657
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 658 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSL 713
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DG G ++ AT
Sbjct: 714 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 773
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 774 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTG 831
Query: 420 R-----GLITVAQPLDFKQERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFE 470
+ ++ P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 832 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 892 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSS 944
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 945 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1004
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHY 618
ED V + TD DVGLN + Y
Sbjct: 1005 SEDVPREFRVVWLNCTDNDVGLNAELSY 1032
Score = 188 bits (458), Expect = 3e-46
Identities = 150/512 (29%), Positives = 235/512 (45%), Gaps = 36/512 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 548 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 605
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTV--LVKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 606 FG-------------SYFDISLYEG-YGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-- 649
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 650 -PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 706
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 707 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 766
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM--TDKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 767 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 826
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 827 N-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 885
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +
Sbjct: 886 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS- 944
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 945 -GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1003
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLS 509
V ED P V+ ++ TD+DVG+NA+++Y ++
Sbjct: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFIT 1035
Score = 185 bits (450), Expect = 2e-45
Identities = 167/566 (29%), Positives = 258/566 (45%), Gaps = 60/566 (10%)
Query: 257 FYTSLFQES---VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP 313
F+T+ F ++ +SE+ P+G S+ ++ A D D N L + ++ ++ ++P
Sbjct: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEE----ASRFFAVEP 82
Query: 314 RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEV 373
+G V+ LDRET++++ + + + D T F Y V
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVS---DHQGVITRKVNIQVGDVNDNAPTFHNQPYSV 139
Query: 374 ELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQ-----NGRGLITVAQP 428
+ E+ P GTP+ + ATD D GG+ F SQ + RG++TV +
Sbjct: 140 RIPENTPVGTPIFIVNATDPDLG-------AGGSVLYSFQPPSQFFAIDSARGIVTVIRE 192
Query: 429 LDFKQERRYVLTVSATDSGGR---SDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD++ + Y LTV+ATD S A + I ITD + P+F N PY+ +++E +P G
Sbjct: 193 LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPG 252
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET-- 543
TTV +++A D D G I Y++ S +N F ++ +G +T N LLDRE
Sbjct: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSI-------FALDYISGVLTLNGLLDRENPL 305
Query: 544 -MSGYLLTVTA---RDGGVPS-LSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
G++LTV D PS + TT I V+D+NDN P F Y+ I E A VG
Sbjct: 306 YSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGF 365
Query: 599 SVS---QVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV------IRTNKALDRES 649
++ QV D ++GLN +E+ F+I P S IR LD E+
Sbjct: 366 ALPLFIQVVDKDENLGLNSM--FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET 423
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
V +D A + P V I + + ND+ P+F + EN +GT++ +
Sbjct: 424 VDRYDFDLFA-NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
Query: 710 RAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
A D D G V Y DD + FSL+ D ++ + LDYE ++ +I
Sbjct: 483 LATDNDAGTFGEVSYFF--SDDPDRFSLD----KDTGLIMLIARLDYELIQRFTLTIIAR 536
Query: 770 ASPPLWNDVRVEILVTDVNDNAPVMK 795
RV I V DVNDN P +
Sbjct: 537 DGGGEETTGRVRINVLDVNDNVPTFQ 562
Score = 175 bits (425), Expect = 2e-42
Identities = 143/514 (27%), Positives = 233/514 (45%), Gaps = 27/514 (5%)
Query: 375 LAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQE 434
++ED P G+ V L A D D D L + ++G F++ G ++ + QPLD + +
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDP-LVFGVSGEEASRFFAVEPDTG--VVWLRQPLDRETK 98
Query: 435 RRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSAT 494
+ + S +D G T V I + D N+ AP F N PY+ + E+ P+GT + +V+AT
Sbjct: 99 SEFTVEFSVSDHQGVI-TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
Query: 495 DSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
D D+G + YS Q F I+ G +T + LD ET Y LTV A
Sbjct: 158 DPDLGAGGSVLYSFQPP---------SQFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
Query: 555 D-GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D LS ++ I + DV D +P+F Y+ NI E + GT+V + A D D G
Sbjct: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-VATH----DLKAVAIDGGTPPQS 668
I Y + F +D SGV+ N LDRE+ + +H +K ++ P
Sbjct: 269 RGIGYTI-VSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 327
Query: 669 STVIV--HIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDE--GPNAVVH 723
+TV +I + DIND+ P F S + I+E + +G + I+ D DE G N++
Sbjct: 328 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387
Query: 724 YSIKGGDDSNSFSLETR-QGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDVRVE 781
+ G + + T QG + + LDYE+ R ++L + P +V+
Sbjct: 388 VYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVK 447
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLIL 841
I + + NDN P+ + Y++ V A D D + ++ +
Sbjct: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFS 507
Query: 842 LNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNE 875
L++ TG + L +L+ + + T+ + DG E
Sbjct: 508 LDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE 541
>AB058715-1|BAB47441.1| 803|Homo sapiens KIAA1812 protein protein.
Length = 803
Score = 297 bits (730), Expect = 3e-79
Identities = 224/711 (31%), Positives = 347/711 (48%), Gaps = 50/711 (7%)
Query: 105 LDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDIS 164
LD E V RY + A + V D + A + + +I++NDN P FS+ Y +S+ E+++
Sbjct: 10 LDYETVDRYDFDLFANES---VPDHVGY-AKVKITLINENDNRPIFSQPLYNISLYENVT 65
Query: 165 VTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYR 224
V + + + ATD D G + Y + +FS+D +G + L+ LDYE ++ +
Sbjct: 66 VGTS--VLTVLATDNDAGTFGEVNYFF--SDDPDRFSLDKDTGLIMLIARLDYELIQRFT 121
Query: 225 LVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDA 284
L I A+DGG T ++ IN+ DVNDN P F + ++ EN P +VR++A D
Sbjct: 122 LTIIARDGGG--EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDE 179
Query: 285 DEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRE--TQAKYQLLVTATDGG 342
D N ++TY++ G+ I++ G + S LD E + L V A D G
Sbjct: 180 DSPPNNQITYSIVSASAFGSY-FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAG 238
Query: 343 DPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYE 402
+PP ++T F Y V + E+ G V+ L ATD D E
Sbjct: 239 NPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQE 298
Query: 403 ITGGNTRG--RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG-GRSD-TAMVQIN 458
+ G +F I +++G IT LD + + Y+L V A D G G + T + +N
Sbjct: 299 SIIYSLEGSTQFRINARSGE--ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVN 356
Query: 459 IT--DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEA 516
IT D N+ P +++APY ++ E P + V V A D D+G N + YS+
Sbjct: 357 ITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP----- 411
Query: 517 VAHHDQQFVINPQTGAI-TTNKLLDRETMSGY------LLTVTARDGGVPSLSDTTD--V 567
++ + +N TG I TT+ +LDRE + + V+ D G P L T+ V
Sbjct: 412 ----NKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV 467
Query: 568 EISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE 627
++++D+NDN+P F+ + A ++E G S+ QV A D D GLNG + Y + P
Sbjct: 468 FVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGMPR 526
Query: 628 GSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF 687
F+I+ +SGV+ T LDRE +A + L+ VA D GTP +SST + I + D+ND P F
Sbjct: 527 MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF 586
Query: 688 ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE 747
+SE+ P + + D D G NA + Y I GG+ FS+ G A
Sbjct: 587 FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV----GYRDAV 642
Query: 748 LVTMVDLDYESPRKKYELVIRAA-SPPL----WNDVRVEILVTDVNDNAPV 793
+ T+V LD E+ Y L++ A + P+ V + V DVNDN P+
Sbjct: 643 VRTVVGLDRET-TAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPI 692
Score = 295 bits (723), Expect = 2e-78
Identities = 218/718 (30%), Positives = 337/718 (46%), Gaps = 64/718 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I +++ ND+ P+F Y S+ E + GT+VLT+ ATD D G EV Y
Sbjct: 38 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVNYFFS------ 91
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D D F +D +G ++ A LD E + R+T+ + A D
Sbjct: 92 ---DDP------------DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---- 132
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIR 188
+T + +N++D NDN P F + Y ++ E + SVT + +++ATD D N+ I
Sbjct: 133 -ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQIT 188
Query: 189 YAIIGGN---TQMQFSIDSLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQL 243
Y+I+ + + S+ G +S+ + LDYEQ+ + L + A D G+P ++T +
Sbjct: 189 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 248
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
I + D NDN P F + SV EN+ G +++ + A D D Y Y+
Sbjct: 249 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSRE----YGQESIIYSL 304
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG--DPPRSATATXXXXXXXXXX 361
I+ RSG + T+ LDRET+++Y L+V A DGG ++ AT
Sbjct: 305 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 364
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNG 419
+ Y + L E PP + V T+ A D D E+ L Y I N +S+ S G
Sbjct: 365 NHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKF--YSLNSTTG 422
Query: 420 RGLITVAQ-----PLDFKQERRYVLTVSATDSGG----RSDTAMVQINITDANNYAPVFE 470
+ T A P + E + VS TD G + +A V +N+ D N+ P F+
Sbjct: 423 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 482
Query: 471 NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
N P+ A V E P G ++ V A D D G+N ++Y + V F+IN +
Sbjct: 483 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP-------VGMPRMDFLINSSS 535
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G + T LDRE ++ Y L V A D G P+ S T+ + I V+DVND P F +Y ++
Sbjct: 536 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 595
Query: 591 MEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESV 650
ED V + TD DVGLN + Y + + +G F + V+RT LDRE+
Sbjct: 596 SEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN-VDGKFSVGYRDAVVRTVVGLDRETT 654
Query: 651 ATHDLKAVAIDGGTPPQ--SSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
A + L AID G + + T V + + D+ND+ P+F + E+ P G +I
Sbjct: 655 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 712
Score = 229 bits (561), Expect = 8e-59
Identities = 181/607 (29%), Positives = 282/607 (46%), Gaps = 45/607 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 139 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 196
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVL--VKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 197 FG-------------SYFDISLYEGY-GVISVSRPLDYEQISNGLIYLTVMAMDAGNPP- 241
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 242 --LNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 297
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 298 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 357
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT--DKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 358 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 417
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 418 NSTTG-KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 476
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +G
Sbjct: 477 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG 536
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTAS 477
++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 537 --VVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 594
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V ED P V+ ++ TD+DVG+NA+++Y ++ + D +F + + + T
Sbjct: 595 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITG-------GNVDGKFSVGYRDAVVRTVV 647
Query: 538 LLDRETMSGYLLTVTARDGGVPSL--SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
LDRET + Y+L + A D G + T V ++V+DVNDN P+F Q Y A++ ED
Sbjct: 648 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIP 707
Query: 596 VGTSVSQ 602
G S+ Q
Sbjct: 708 EGHSILQ 714
Score = 173 bits (420), Expect = 1e-41
Identities = 158/524 (30%), Positives = 241/524 (45%), Gaps = 55/524 (10%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDS-GGRSDTAMVQINITDANNYAPVFENAPYTASVFED 481
I VA PLD++ RY + A +S A V+I + + N+ P+F Y S++E+
Sbjct: 4 IRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 63
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
+GT+VL V ATD+D G ++ Y S + +F ++ TG I LD
Sbjct: 64 VTVGTSVLTVLATDNDAGTFGEVNYFFSDD---------PDRFSLDKDTGLIMLIARLDY 114
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVS 601
E + + LT+ ARDGG T V I+V+DVNDN P F++ Y + E+ T +
Sbjct: 115 ELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV 172
Query: 602 QVGATDADVGLNGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKA 657
++ ATD D N +I Y + F I GVI ++ LD E ++ L
Sbjct: 173 RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTV 232
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE- 716
+A+D G PP +STV V I++ D ND+PP F + EN G T+ + A D D
Sbjct: 233 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 292
Query: 717 ---GPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPP 773
G +++ YS++G S F + R G E+ T LD E+ + +Y L++RA
Sbjct: 293 REYGQESII-YSLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGG 343
Query: 774 LWNDVR-----VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK-- 826
+ ++ + V I + D+NDN P KD N + P V A D D+ +
Sbjct: 344 VGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGT 403
Query: 827 LQYRILSGNNANLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKA 878
L Y I N LN TTG + T L+ P + + VSVTD G +KA
Sbjct: 404 LVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 461
Query: 879 MMQLSVRLITEEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+V +N + + ND T + P + ++G+ A
Sbjct: 462 TSSATV-------FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 496
>L11370-1|AAA36419.1| 1026|Homo sapiens protocadherin 42 protein.
Length = 1026
Score = 294 bits (721), Expect = 3e-78
Identities = 209/735 (28%), Positives = 347/735 (47%), Gaps = 53/735 (7%)
Query: 91 RIDGRSGALLT-RASLDREKVARYT--------VL---VKATDQASPVSDRLSSTATIHV 138
R+DG++G + T S+DRE + +L V TD S RL +
Sbjct: 78 RVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNASPRLLEG---QI 134
Query: 139 NIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQM 198
+ D NDN P F+ T+++ E+ ++ + A+D D G N Y + Q+
Sbjct: 135 EVQDINDNTPNFASPVITLAIPENTNI--GSLFPIPLASDRDAGPNGVASYEL-----QV 187
Query: 199 QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFY 258
+ + ++ LD E+ SY L I+ QDGGSP R+ + L + + D NDNAP+F
Sbjct: 188 AEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRATSALLRVTVLDTNDNAPKFE 247
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
++ +SEN PIG+S+++V+A D+D+G NAE+ YT V + +D +G +
Sbjct: 248 RPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV--VRRLLRLDRNTGLI 305
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF-MPG-------Q 370
G +DRE + + V A D G P+SA A + G
Sbjct: 306 TVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQD 365
Query: 371 YEVELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNG-----RGLIT 424
++ED T V + +D DE +N + G+ + S+ G + +
Sbjct: 366 GMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQ 425
Query: 425 VAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
PLD+++ + Y + + A DSG S T +++ + D N+ APVF + + E+
Sbjct: 426 TTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENN 485
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
G + ++A+D+D G NA++ YSL E + + + F I+P+TG I LDRE
Sbjct: 486 KPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL------FTISPETGEIQVKTSLDRE 539
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
Y L V A D G PSL T V ++V+D NDN+P F Y ++ME+ + V
Sbjct: 540 QRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGM 599
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDG 662
V D D G N ++ + +++ G FVI +G I ++ + DRE +T+ + A+DG
Sbjct: 600 VTVIDGDKGENAQVQLSV---EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDG 656
Query: 663 GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFY--ISENSPIGTTIGEIRAHDPDEGPNA 720
G PP+S+ V V I + D ND+ P + T + ++ + +G T+ ++ A D D G NA
Sbjct: 657 GVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNA 716
Query: 721 VVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRV 780
+ YSI GG+ F + + G+ L ++ + + V PP + V
Sbjct: 717 ELIYSIAGGNPYGLFQIGSHSGA--ITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALV 774
Query: 781 EILVTDVNDNAPVMK 795
+ V + N +++
Sbjct: 775 HLYVNETLANRTLLE 789
Score = 247 bits (605), Expect = 4e-64
Identities = 197/695 (28%), Positives = 314/695 (45%), Gaps = 60/695 (8%)
Query: 4 PFCIHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIE 63
P + QI V D ND++P F ++ E + G+ A+D+D G N Y ++
Sbjct: 127 PRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ 186
Query: 64 LVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQA 123
+ ED + + L+ +LDRE+ Y + +K D
Sbjct: 187 VA-------EDQ-----------------EEKQPQLIVMGNLDRERWDSYDLTIKVQDGG 222
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGA 183
SP +++A + V ++D NDN P+F +Y + E+ + + + ++KA D+D GA
Sbjct: 223 SPPR---ATSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS--VIQVKANDSDQGA 277
Query: 184 NSAIRYAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
N+ I Y ++ +D +G +++ +D E + + R + A+D G+ +S
Sbjct: 278 NAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARA 337
Query: 242 QLLINIRDVNDNAPRFYTS-----LFQE---SVSENVPIGYSIVRVQAYDADEGVNAELT 293
Q+++ ++D+NDNAP Q+ ++SE+V ++ VQ D DEG NA +T
Sbjct: 338 QVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT 397
Query: 294 YTMT-DKDYTGNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATAT 351
+ D + D + + + T+ LD E Y + + A D G+PP S+T +
Sbjct: 398 CVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNS 457
Query: 352 XXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNT- 408
F EV E+ PG + +TA+DAD + L Y +
Sbjct: 458 LKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAA 517
Query: 409 RGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYA 466
+G F+I+ + G I V LD +Q Y L V A D G S TA V +N+ D N+
Sbjct: 518 KGLFTISPETGE--IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDND 575
Query: 467 PVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
P F + Y SV E+ P + V +V+ D D G NAQ+ S+ + + FVI
Sbjct: 576 PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQD---------NGDFVI 626
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLY 586
TG I ++ DRE S Y + A DGGVP S V I+V+D NDN P
Sbjct: 627 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 686
Query: 587 TAN--IMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA 644
T++ + +G +VSQV A D D G+N + Y + G F I SG I K
Sbjct: 687 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI-AGGNPYGLFQIGSHSGAITLEKE 745
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIED 679
++R H L D G PP+ T +VH+ + +
Sbjct: 746 IERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 780
Score = 247 bits (604), Expect = 5e-64
Identities = 183/645 (28%), Positives = 286/645 (44%), Gaps = 34/645 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
I ++D+NDN P F + + ++ EN IG A D D G N +Y + +
Sbjct: 134 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQVAEDQ-- 191
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ + + G LDRE Y L + DGG PPR+ +A
Sbjct: 192 -------EEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRATSALLRVTVLDTNDNAP 244
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG--RFSITSQNGRGL 422
F YE EL+E+ P G V+ + A D+D+ E T R + GL
Sbjct: 245 KFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGL 304
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFE--------NA 472
ITV P+D + +V A D G +A Q+ +T D N+ AP E +
Sbjct: 305 ITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQ 364
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
A++ ED T V +V +D D G NA +T ++ ++ + + + + +
Sbjct: 365 DGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ-LRQASETGSDSKKKYF 423
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ T LD E + Y + + A D G P LS T +++ VVDVNDN PVF Q + E
Sbjct: 424 LQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPE 483
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVAT 652
+ G ++++ A+DAD G N + Y L+P+ +G F I P +G I+ +LDRE +
Sbjct: 484 NNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRES 543
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
++LK VA D G+P T V + + D ND+ P F F + EN P + +G +
Sbjct: 544 YELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVI 603
Query: 713 DPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASP 772
D D+G NA V S++ D+ F ++ G+ + L D + +S + P
Sbjct: 604 DGDKGENAQVQLSVE--QDNGDFVIQNGTGTILSSL--SFDREQQSTYTFQLKAVDGGVP 659
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA------YDADVTDK 826
P V V I V D NDNAP + ++K P G + +D+ V +
Sbjct: 660 PRSAYVGVTINVLDENDNAPYIT--APSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAE 717
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
L Y I GN L + +G++TL ++ L + V V+D
Sbjct: 718 LIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 762
Score = 234 bits (573), Expect = 3e-60
Identities = 195/648 (30%), Positives = 295/648 (45%), Gaps = 70/648 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD ND++P FE YEA + E + G +V+ +KA D D G NAE+EYT
Sbjct: 233 RVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA---- 288
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
PE V+ + R+D +G + + +DRE ++ V A D+ + +
Sbjct: 289 --PE-----------VVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT---NP 332
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDED----IS--VTDNPVIAKIKATDADVGA 183
S+ A + V + D NDN P + + +D IS V + +A ++ +D D G
Sbjct: 333 KSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGE 392
Query: 184 NSAIRYAIIGGNTQMQFSIDSLSGDVSLVK-------TLDYEQVRSYRLVIRAQDGGSPS 236
N+A+ ++ G+ Q S +G S K LDYE+V+ Y + I A D G+P
Sbjct: 393 NAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPP 451
Query: 237 RSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM 296
S+T L + + DVNDNAP F S+ + + EN G I + A DAD G NAEL Y++
Sbjct: 452 LSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL 511
Query: 297 TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXX 356
+ + TI P +G + LDRE + Y+L V A D G P TAT
Sbjct: 512 EPEPAAKGL---FTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNV 568
Query: 357 XXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS 416
FM Y + E+ P +PV +T D D+ +++ G F I
Sbjct: 569 LDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI-- 626
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
QNG G I + D +Q+ Y + A D G RS V IN+ D N+ AP + AP
Sbjct: 627 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPS 685
Query: 475 TAS---VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
S + +G TV V+A D D G+NA++ YS+ A + F I +G
Sbjct: 686 NTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI-------AGGNPYGLFQIGSHSG 738
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
AIT K ++R + L V D G P T V + V NE + + L
Sbjct: 739 AITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV-----NETLANRTLL----- 788
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVI 639
+ L+G S+ T D+ + G YE + ++ G+ + +GV+
Sbjct: 789 -ETLLGHSLD----TPLDIDIAGDPEYE---RSKQRGNILFGVVAGVV 828
Score = 182 bits (444), Expect = 1e-44
Identities = 153/507 (30%), Positives = 239/507 (47%), Gaps = 40/507 (7%)
Query: 429 LDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGT 486
LD ++ Y LT+ D G R+ +A++++ + D N+ AP FE Y A + E++PIG
Sbjct: 204 LDRERWDSYDLTIKVQDGGSPPRATSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 263
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
+V+ V A DSD G NA+I Y+ + E V + ++ TG IT +DRE +S
Sbjct: 264 SVIQVKANDSDQGANAEIEYTFHQ--APEVVR---RLLRLDRNTGLITVQGPVDREDLST 318
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQ---LYT-----ANIMEDALVGT 598
+V A+D G S V ++V D+NDN P + + L T ANI ED T
Sbjct: 319 LRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEET 378
Query: 599 SVSQVGATDADVGLN--------GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESV 650
+V+ V +D D G N G + ++L E GS ++T LD E V
Sbjct: 379 AVALVQVSDRDEGENAAVTCVVAGDVPFQLRQAS-ETGSD--SKKKYFLQTTTPLDYEKV 435
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
+ ++ VA+D G PP SST + +++ D+ND+ PVF EN+ G I EI
Sbjct: 436 KDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEIT 495
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
A D D G NA + YS++ + F++ G E+ LD E R+ YEL + A
Sbjct: 496 ASDADSGSNAELVYSLEPEPAAKGLFTISPETG----EIQVKTSLDREQ-RESYELKVVA 550
Query: 770 A---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK 826
A SP L V + V D NDN P F+ ++ + P G V D D +
Sbjct: 551 ADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGEN 610
Query: 827 LQYRI-LSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSV 884
Q ++ + +N + ++ N TG++ S + T ++ D GV A + +++
Sbjct: 611 AQVQLSVEQDNGDFVIQN-GTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTI 669
Query: 885 RLITEEMLLNSITVRLNDMTAEQFLSP 911
++ E IT N T+ + L+P
Sbjct: 670 NVLDENDNAPYITAPSN--TSHKLLTP 694
Score = 148 bits (359), Expect = 2e-34
Identities = 123/417 (29%), Positives = 191/417 (45%), Gaps = 41/417 (9%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE 515
QI + D N+ P F + T ++ E+ IG+ + A+D D G N +Y L +++ +
Sbjct: 133 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL--QVAED 190
Query: 516 AVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVN 575
Q V+ LDRE Y LT+ +DGG P + + + ++V+D N
Sbjct: 191 QEEKQPQLIVMGN----------LDRERWDSYDLTIKVQDGGSPPRATSALLRVTVLDTN 240
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDP 634
DN P F++ Y A + E++ +G SV QV A D+D G N I Y + +D
Sbjct: 241 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 300
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G+I +DRE ++T +A D GT P+S+ V + ++D+ND+ P E +
Sbjct: 301 NTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGL 360
Query: 695 Y--------ISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSD-- 744
ISE+ T + ++ D DEG NA V + GD + GSD
Sbjct: 361 VTHQDGMANISEDVAEETAVALVQVSDRDEGENAAV-TCVVAGDVPFQLRQASETGSDSK 419
Query: 745 -KAELVTMVDLDYESPRK-KYELV-IRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIF 801
K L T LDYE + E+V + + +PPL + +++ V DVNDNAPV
Sbjct: 420 KKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEV 479
Query: 802 NNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNE----TTGSMTLSPQ 854
++ P + A DAD SG+NA L+ E G T+SP+
Sbjct: 480 AFPENNKPGEVIAEITASDAD----------SGSNAELVYSLEPEPAAKGLFTISPE 526
>AK127704-1|BAC87093.1| 1366|Homo sapiens protein ( Homo sapiens
cDNA FLJ45804 fis, clone NT2RI3005923, weakly similar
to Cadherin-related tumor suppressor precursor. ).
Length = 1366
Score = 290 bits (711), Expect = 6e-77
Identities = 251/844 (29%), Positives = 371/844 (43%), Gaps = 75/844 (8%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
+ +I V D NDHSP F + + V E + GT A D D G + YT+ +
Sbjct: 151 VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPGAHDPDAGLFSTQGYTLVQPS 210
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGAL-----LTRASLDREKVARYTVLVKATD 121
+P + G S L + LDRE+ A + + ++A D
Sbjct: 211 DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
P R + ++ + ++D+NDN P F + Y +V ED + +++ATD D+
Sbjct: 271 GGRP---RRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQ--PGAEVCRVRATDRDL 325
Query: 182 GANSAIRYAI---------IGGNT---QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRA 229
G N +RY++ GG F+++ LSG V + + LD E ++LV+ A
Sbjct: 326 GPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEA 385
Query: 230 QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES----VSENVPIGYSIVRVQAYDAD 285
+DGG+ T ++ I + DVNDN P + E VSE G + RV DAD
Sbjct: 386 RDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAD 445
Query: 286 ------EGVNAELTYTMTDKDYT-----GNVDLPITIDPRSG--WVYTSGQLDRETQAKY 332
+ EL + D + G D + G ++ G LDRE++ Y
Sbjct: 446 GDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLY 505
Query: 333 QLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATD 392
+LL+ ATD G PP S T F Y+ ++E PGT V+ ++A+D
Sbjct: 506 ELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASD 565
Query: 393 ADEDNR----LHYEITG-------GNTRGRFSITSQNG--------RGLITVAQPLDFKQ 433
ADE L Y + G+ + T++ G G+I+ + LD +
Sbjct: 566 ADEAGSDHAWLRYTVVQLSAPCNLGSLESKMVHTAECGPSFAIDSESGVISTIRALDREV 625
Query: 434 ERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVV 491
+ L V A D G S T +V I + D N+ P+F Y A++ E AP+G L V
Sbjct: 626 QEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQV 685
Query: 492 SATDSDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE-TMSGYLL 549
+A+D+D G+ I YSL +S EA Q F I+P G I ++ +DRE + Y L
Sbjct: 686 TASDADSGLYGFIEYSLYDGFLSYEA----PQAFRIDPHDGQICVSQDIDRERDPATYDL 741
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
V A+DGG LS V + + DVNDN PVF Y +I ++ GT + V ATD D
Sbjct: 742 LVEAKDGG--GLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD 799
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G+ G + YEL P F ID +G+I L T L A DGG
Sbjct: 800 SGIYGTVAYELIP-GNVSSLFTIDSTTGIIYLTLPLSHLESTTLLLMVSAQDGGGLTAVI 858
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
V I I +P FE TF + E+ P + IG ++A +P + + Y I G
Sbjct: 859 NADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSG 917
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDVRVEILVTDVN 788
D FS+ R G+ + T LD+E+ P + + S P + V I V DVN
Sbjct: 918 DLGGKFSIHPRLGT----IRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVN 973
Query: 789 DNAP 792
DN P
Sbjct: 974 DNHP 977
Score = 286 bits (702), Expect = 7e-76
Identities = 270/903 (29%), Positives = 396/903 (43%), Gaps = 69/903 (7%)
Query: 7 IHQQINVLDCNDHSP----VFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
+ I VLD ND+ P +F + A V EGA G V + +D D E E T
Sbjct: 397 VRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATG 456
Query: 63 ELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGA--LLTRASLDREKVARYTVLVKAT 120
EL + D G G L LDRE Y +L+ AT
Sbjct: 457 EL----GVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVAT 512
Query: 121 DQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDAD 180
D SP LS+ T+ + + D ND P FS++ Y SV E + V+ + A+DAD
Sbjct: 513 DAGSPP---LSTEETLLLRVADLNDQPPLFSQQHYKASVSE--AAAPGTVVMWVSASDAD 567
Query: 181 -VGANSA-IRYAIIG-------GNTQMQ----------FSIDSLSGDVSLVKTLDYEQVR 221
G++ A +RY ++ G+ + + F+IDS SG +S ++ LD E
Sbjct: 568 EAGSDHAWLRYTVVQLSAPCNLGSLESKMVHTAECGPSFAIDSESGVISTIRALDREVQE 627
Query: 222 SYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQA 281
+ L + AQD G P S T + I + DVNDN P F+ ++ +++E+ P+G+ ++V A
Sbjct: 628 AVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTA 687
Query: 282 YDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQ-AKYQLLVTATD 340
DAD G+ + Y++ D + IDP G + S +DRE A Y LLV A D
Sbjct: 688 SDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD 747
Query: 341 GGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADED--NR 398
GG SA A F P Y ++++ PGT ++ + ATD D
Sbjct: 748 GGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGT 805
Query: 399 LHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSD--TAMVQ 456
+ YE+ GN F+I S G+I + PL + +L VSA D GG + A V
Sbjct: 806 VAYELIPGNVSSLFTIDSTT--GIIYLTLPLSHLESTTLLLMVSAQDGGGLTAVINADVT 863
Query: 457 INITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEA 516
I+I FE YT V+ED P + + V A + + + I Y +SS
Sbjct: 864 IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISS------ 916
Query: 517 VAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVND 576
+F I+P+ G I T K LD ET +LTV A+ G P+ S +T+V I+V+DVND
Sbjct: 917 -GDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACS-STEVNITVMDVND 974
Query: 577 NEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPAS 636
N P F + I + GT++ A D D G NG I Y + + G F ID A
Sbjct: 975 NHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI--ASPQPGVFAIDRAL 1032
Query: 637 GVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPP-VFESDCLTFY 695
GV+ N +L L A D G PQ++ +++ + IE SP FE
Sbjct: 1033 GVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVE 1092
Query: 696 ISENSPIGTTIGEIRAHD-PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
+SE+ T + + +AH + + + YS++ DS F + G +
Sbjct: 1093 VSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTG----WIYLRRQF 1148
Query: 755 DYESPRKKYELVIRAASPP---LWN-DVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPV 810
DYES + Y + A P L N V + V D NDN+P + + P
Sbjct: 1149 DYES-TQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQ 1207
Query: 811 GPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVS 868
G G++ A D D +L Y +LS + +N TG + L+ M V
Sbjct: 1208 GVIGKITAIDMDSGKNGQLLYFLLS--DGKFFKMNPNTGELINWVALDREHRGHHEMTVL 1265
Query: 869 VTD 871
VTD
Sbjct: 1266 VTD 1268
Score = 256 bits (626), Expect = 1e-66
Identities = 228/800 (28%), Positives = 342/800 (42%), Gaps = 52/800 (6%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDI--GKNAEVEYTIELVTAD 68
+ V D ND P+F Q Y+ASV E A+ GT V+ + A+D D +A + YT+ ++A
Sbjct: 527 LRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ F ID SG + T +LDRE + V A D P
Sbjct: 587 C--NLGSLESKMVHTAECGPSFAIDSESGVISTIRALDREVQEAVELKVVAQDLGEP--- 641
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
LS+T + + + D NDN P F + Y ++ E V ++ A+DAD G I
Sbjct: 642 PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPV--GHCFLQVTASDADSGLYGFIE 699
Query: 189 YAIIGG----NTQMQFSIDSLSGDVSLVKTLDYEQ-VRSYRLVIRAQDGGSPSRSNTTQL 243
Y++ G F ID G + + + +D E+ +Y L++ A+DGG S +
Sbjct: 700 YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVR- 758
Query: 244 LINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG 303
+++ DVNDN P F S + S+S+ G I+ V A D D G+ + Y + G
Sbjct: 759 -VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL----IPG 813
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
NV TID +G +Y + L L+V+A DGG A
Sbjct: 814 NVSSLFTIDSTTGIIYLTLPLSHLESTTLLLMVSAQDGGGLTAVINADVTIHIFQTTLAP 873
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATD-ADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + ED P +P+ T+ A + + + Y I+ G+ G+FSI + G
Sbjct: 874 AEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPR--LGT 931
Query: 423 ITVAQPLDFKQERRYVLTVSA-TDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFED 481
I +PLD + + VLTV A S + V I + D N+ P F + +
Sbjct: 932 IRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
P GT + + A D D G N I YS++S F I+ G + N L
Sbjct: 992 TPPGTALYLARAEDRDSGRNGLIRYSIASP--------QPGVFAIDRALGVLFLNGSLGA 1043
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP--VFKQQLYTANIMEDALVGTS 599
LT+ A D GV + + + V++ ++ P F+ +Y + E T
Sbjct: 1044 GEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESLSPMTQ 1102
Query: 600 VSQVGATD-ADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAV 658
+ Q A + Y L+P + F I P +G I + D ES T++ +
Sbjct: 1103 MLQTQAHPLGPQRAASPLRYSLEP-SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVF 1161
Query: 659 A---IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
A DG S+TVIV ++ D ND+ P F D L + E+ IG+I A D D
Sbjct: 1162 AWIPEDGFLQNVSTTVIV--RVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 1219
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE---LVIRAASP 772
G N + Y + D F + G EL+ V LD E R +E LV SP
Sbjct: 1220 SGKNGQLLYFLL--SDGKFFKMNPNTG----ELINWVALDREH-RGHHEMTVLVTDRGSP 1272
Query: 773 PLWNDVRVEILVTDVNDNAP 792
P + V + VTD+NDN P
Sbjct: 1273 PRNATMAVYVSVTDINDNRP 1292
Score = 234 bits (573), Expect = 3e-60
Identities = 211/736 (28%), Positives = 321/736 (43%), Gaps = 69/736 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V D ND+ P+F Q Y A++ E A G L + A+D D G +EY++ D
Sbjct: 651 ITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY----DGF 706
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREK-VARYTVLVKATDQASPVSDR 129
+A FRID G + +DRE+ A Y +LV+A D
Sbjct: 707 LSYEA-----------PQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGG----- 750
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
LS+ A + V++ D NDN+P F+ TY S+ ++ I + ATD D G + Y
Sbjct: 751 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQ--PGTEIINVLATDQDSGIYGTVAY 808
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
+I GN F+IDS +G + L L + + + L++ AQDGG + + I+I
Sbjct: 809 ELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLLLMVSAQDGGGLTAVINADVTIHIFQ 868
Query: 250 VNDNAPRF----YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
F YT L E V E+ PIG R + ++ E + Y ++ D G
Sbjct: 869 TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPI----FYRISSGDLGGK- 922
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+I PR G + T LD ETQ L V A G P S+T
Sbjct: 923 ---FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA- 978
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNGRGLI 423
F+ E+ +++ PPGT + A D D + Y I G F+I G++
Sbjct: 979 FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP-GVFAI--DRALGVL 1035
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT-DANNYAP--VFENAPYTASVFE 480
+ L ++R LT+ A D G A++ + + + ++P FE+ Y V E
Sbjct: 1036 FLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSE 1095
Query: 481 DAPIGTTVLVVSATDSDVGINAQ-ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
T +L A A + YSL + + F I P TG I +
Sbjct: 1096 SLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSA-------MFGIRPYTGWIYLRRQF 1148
Query: 540 DRETMSGYLLTVTA---RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D E+ Y V A DG + ++S T V + V D NDN P F + + E +
Sbjct: 1149 DYESTQTYNFRVFAWIPEDGFLQNVSTT--VIVRVWDENDNSPTFLHDVLFLKVEESPVP 1206
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDRESVATHDL 655
+ ++ A D D G NG++ Y L +G F ++P +G + ALDRE H++
Sbjct: 1207 QGVIGKITAIDMDSGKNGQLLYFL----LSDGKFFKMNPNTGELINWVALDREHRGHHEM 1262
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT-----FYISENSPIGTTIGEIR 710
+ D G+PP+++T+ V++ + DIND+ P F CL + E P+ + +
Sbjct: 1263 TVLVTDRGSPPRNATMAVYVSVTDINDNRPFF-PQCLPGKELHVKVLEGQPVNMLVTTVF 1321
Query: 711 AHDPDEGPNAVVHYSI 726
A DPDEG NA V YS+
Sbjct: 1322 AKDPDEGNNAEVTYSV 1337
Score = 203 bits (495), Expect = 8e-51
Identities = 209/742 (28%), Positives = 315/742 (42%), Gaps = 75/742 (10%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
F + +G + + LD E+ Y V G Q+ I + DVND++PRF
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGA------VVQVEIRVNDVNDHSPRFPL 169
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD-----KDYTGNV--------- 305
Q VSE P G + A+D D G+ + YT+ KD G
Sbjct: 170 DSLQLDVSELSPPGTAFRLPGAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 306 DLPITIDPRSGW------VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
LP + P S + +LDRE A ++L + A DGG P R+ +
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEI---------TGGNT 408
F +Y + ED PG V + ATD D + + Y + +GG
Sbjct: 290 NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
Query: 409 RGRFSITS-QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNY 465
G + + + G++ V +PLD + + + L V A D G + A V+++I D N+
Sbjct: 350 LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDN 409
Query: 466 AP----VFENAPYTASVFEDAPIGTTVLVVSATDSDVG------INAQITYSLSSEISNE 515
P +F A V E A G V VS +D+D ++ L +
Sbjct: 410 RPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISL 469
Query: 516 AVAHHDQQFVINP--QTGA--ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++ + F + P G + LDRE+ Y L + A D G P LS + + V
Sbjct: 470 SLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRV 529
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD-------------VGLNGRIHY 618
D+ND P+F QQ Y A++ E A GT V V A+DAD V L+ +
Sbjct: 530 ADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL 589
Query: 619 -ELDPK---DREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
L+ K E G SF ID SGVI T +ALDRE +LK VA D G PP S+T +V
Sbjct: 590 GSLESKMVHTAECGPSFAIDSESGVISTIRALDREVQEAVELKVVAQDLGEPPLSATCLV 649
Query: 674 HIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSN 733
I ++D+ND+ P+F I+E++P+G ++ A D D G + YS+ G S
Sbjct: 650 SITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSY 709
Query: 734 SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
R ++ D+D E Y+L++ A L V + + DVNDN P
Sbjct: 710 EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHP 769
Query: 793 VMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSMT 850
V + + + P V A D D + + Y ++ GN ++L ++ TTG +
Sbjct: 770 VFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIY 829
Query: 851 LSPQLNTNVPKLATMEVSVTDG 872
L+ L+ + VS DG
Sbjct: 830 LTLPLSHLESTTLLLMVSAQDG 851
Score = 109 bits (261), Expect = 2e-22
Identities = 111/435 (25%), Positives = 189/435 (43%), Gaps = 32/435 (7%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F I R G + TR LD E + V+A ++P S+ +++ ++D NDN+P
Sbjct: 923 FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPAC----SSTEVNITVMDVNDNHPA 978
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDV 209
F + + + + + + +A D D G N IRY+I + F+ID G +
Sbjct: 979 FLRTSDEIRISQ--TTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV-FAIDRALGVL 1035
Query: 210 SLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPR--FYTSLFQESVS 267
L +L + R L +RA+D G ++ L + I + +++P F ++Q VS
Sbjct: 1036 FLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVI-EKREHSPSWTFEHLVYQVEVS 1094
Query: 268 ENVPIGYSIVRVQAYD-ADEGVNAELTYTMTDKDYTGNVDLPIT-IDPRSGWVYTSGQLD 325
E++ +++ QA+ + + L Y++ +VD + I P +GW+Y Q D
Sbjct: 1095 ESLSPMTQMLQTQAHPLGPQRAASPLRYSLEP-----SVDSAMFGIRPYTGWIYLRRQFD 1149
Query: 326 RETQAKYQLLVTATDGGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
E+ Y V A D ++ + T F+ +++ E P
Sbjct: 1150 YESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV 1209
Query: 385 VVTLTATDADEDNR---LHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ +TA D D L++ ++ G F + G + VA LD + + +TV
Sbjct: 1210 IGKITAIDMDSGKNGQLLYFLLSDGKF---FKMNPNTGELINWVA--LDREHRGHHEMTV 1264
Query: 442 SATDSGG--RSDTAMVQINITDANNYAPVFENA----PYTASVFEDAPIGTTVLVVSATD 495
TD G R+ T V +++TD N+ P F V E P+ V V A D
Sbjct: 1265 LVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKD 1324
Query: 496 SDVGINAQITYSLSS 510
D G NA++TYS+SS
Sbjct: 1325 PDEGNNAEVTYSVSS 1339
Score = 35.1 bits (77), Expect = 3.7
Identities = 38/132 (28%), Positives = 55/132 (41%), Gaps = 6/132 (4%)
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
LT + E P T +G+IRA P + + D + + D + T
Sbjct: 69 LTLSVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTA 128
Query: 752 VDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
LD E R Y V A+ L V+VEI V DVND++P + + + P G
Sbjct: 129 RRLDRER-RDHYSFV---AATLLGAVVQVEIRVNDVNDHSPRF-PLDSLQLDVSELSPPG 183
Query: 812 PFGRVP-AYDAD 822
R+P A+D D
Sbjct: 184 TAFRLPGAHDPD 195
>AY861435-1|AAX56125.1| 1065|Homo sapiens protocadherin 11X isoform
5 protein.
Length = 1065
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AY861434-1|AAX56124.1| 1329|Homo sapiens protocadherin 11X isoform
6 protein.
Length = 1329
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AY861433-1|AAX56123.1| 1310|Homo sapiens protocadherin 11X isoform
7 protein.
Length = 1310
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AY861432-1|AAX56122.1| 1339|Homo sapiens protocadherin 11X isoform
8 protein.
Length = 1339
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AL133321-2|CAI41436.1| 1337|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1337
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AL133321-1|CAI41435.1| 1347|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1347
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AL133274-3|CAI41629.1| 1310|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1310
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AL133274-2|CAI41631.1| 1337|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1337
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AL133274-1|CAI41630.1| 1347|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1347
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AL121869-5|CAI41414.1| 1337|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1337
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AL121869-4|CAI41413.1| 1347|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1347
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AL121869-3|CAI41412.1| 1310|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1310
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AJ276804-1|CAC13123.1| 1025|Homo sapiens protocadherin protein.
Length = 1025
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AF332219-1|AAK13471.1| 1337|Homo sapiens protocadherin 11 protein.
Length = 1337
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AF332218-1|AAK13470.1| 1347|Homo sapiens protocadherin 11 protein.
Length = 1347
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AB026187-1|BAA90765.1| 1021|Homo sapiens protocadherin-Xa protein.
Length = 1021
Score = 281 bits (688), Expect = 3e-74
Identities = 210/677 (31%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (642), Expect = 1e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 168 bits (409), Expect = 2e-40
Identities = 134/415 (32%), Positives = 198/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>BX537422-1|CAD97664.1| 1203|Homo sapiens hypothetical protein
protein.
Length = 1203
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AL603863-3|CAM17491.1| 1237|Homo sapiens protocadherin 9 protein.
Length = 1237
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AL603863-2|CAH72759.1| 1203|Homo sapiens protocadherin 9 protein.
Length = 1203
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AL603863-1|CAH72758.1| 1032|Homo sapiens protocadherin 9 protein.
Length = 1032
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AL355173-2|CAH72612.1| 1203|Homo sapiens protocadherin 9 protein.
Length = 1203
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AL355173-1|CAM17290.1| 1237|Homo sapiens protocadherin 9 protein.
Length = 1237
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AL138814-1|CAM13066.1| 1237|Homo sapiens protocadherin 9 protein.
Length = 1237
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AL136999-2|CAI12502.1| 1203|Homo sapiens protocadherin 9 protein.
Length = 1203
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AL136999-1|CAM13771.1| 1237|Homo sapiens protocadherin 9 protein.
Length = 1237
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AF169692-1|AAF89689.2| 1203|Homo sapiens protocadherin-9 protein.
Length = 1203
Score = 280 bits (687), Expect = 4e-74
Identities = 189/623 (30%), Positives = 301/623 (48%), Gaps = 31/623 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
I + + D NDN P F +S+ E+ + I ATD D G N Y ++ G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPS--ATDPDTGFNGVQHYELLNGQ 185
Query: 196 TQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
+ I ++ G+ + + + LD EQ +Y + I+ +DGG+P +S+T L + + DV
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F + + EN P+G S++++ A DAD G NAE+ Y + L
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FA 304
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXX----XXXXXXXF 366
++ +G + LDRE A +++ V A+DG P AT T
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYII 364
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS-QNGRGLITV 425
P V L+E +P T + +T +D D D I F + + + + L+
Sbjct: 365 SPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 426 AQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+ LD++ + + + A+DSG S TA+V++ + D N+ P+F SV E+
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G + +SATD D G NA I Y L S F ++ +TG +T +++ DRE
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNAS---------FFDLDRKTGVLTASRVFDREE 534
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
++ TVTARD G P L V ++V+D NDN P F + + E+ ++V +
Sbjct: 535 QERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
TDAD G N + + + +FV+DP SGVI++N + DRE +++ A DGG
Sbjct: 595 TVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSPI-GTTIGEIRAHDPDEGPNA 720
PP+SST V I + D+ND+ PV S +F + S I G+ + E+ A D D G NA
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 721 VVHYSIKGGDDSNSFSLETRQGS 743
+ Y+I G++ F ++ G+
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGN 734
Score = 263 bits (644), Expect = 7e-69
Identities = 194/654 (29%), Positives = 303/654 (46%), Gaps = 47/654 (7%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
++ I ++D NDNAP F + + S+ EN I A D D G N Y + +
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ T + W + LDRE + Y + + DGG P +S+TA
Sbjct: 187 VFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV 245
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-----NTRGRFSI 414
F GQ EV + E+ P GT V+ L ATDAD + G T+ F++
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFE---- 470
N GLITV + LD ++ + +TV A+D A V IN+TD N+ P +
Sbjct: 306 --NNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYI 363
Query: 471 NAPYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+P +V+ E P+ T + +++ +D D +N ++ + E+ A +D Q+++
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE- 422
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
T+ LLD E + + A D G PSL+ T V + + D NDN P+F Q +
Sbjct: 423 ------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRE 648
++ E+ G ++ + ATD D G N I Y+L P F +D +GV+ ++ DRE
Sbjct: 477 SVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---NASFFDLDRKTGVLTASRVFDRE 533
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A D GTPP S V + + D ND+ P F + F++SEN P +T+G
Sbjct: 534 EQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV 593
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I D D G N V SI +D+++F L+ G K+ V D E + Y ++
Sbjct: 594 ITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN----VSFDREQ-QSSYTFDVK 646
Query: 769 A---ASPPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPFGRVPAY 819
A PP + +V I V DVNDN+PV+ F+++ P V A
Sbjct: 647 ATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLV---PLSAIPGSVVAEVFAV 703
Query: 820 DAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
D D + +L+Y I+SGNN L ++ TG++TL + L + V+++D
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISD 757
Score = 239 bits (586), Expect = 8e-62
Identities = 193/686 (28%), Positives = 316/686 (46%), Gaps = 54/686 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND++P+F S+ E + ATD D G N Y EL+ +
Sbjct: 129 KIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHY--ELLNGQS 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ D + L+ + +LDRE+ Y + +K D +P +
Sbjct: 187 VFGLDIVETPEGE------------KWPQLIVQQNLDREQKDTYVMKIKVEDGGTP---Q 231
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + V + D NDN P F E V + E+ V + + ++ ATDAD+G+N+ IRY
Sbjct: 232 KSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTS--VIQLHATDADIGSNAEIRY 289
Query: 190 ---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQLLI 245
A + T+ F++++ +G +++ ++LD E+ +++ + A DG S P+R+ T I
Sbjct: 290 IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT---I 346
Query: 246 NIRDVNDNAP----RFYTSLFQESV--SENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
N+ DVNDN P R+ S +V SE P+ I + D D VN ++ ++
Sbjct: 347 NVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIER 405
Query: 300 DYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+ ++ + + TS LD E ++ + A+D G P + TA
Sbjct: 406 EVPFHLK---AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNG 419
F E+ ++E+ G + T++ATD D G F + +
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKT- 521
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS 477
G++T ++ D +++ R++ TV+A D+G A V + + D N+ +P F + +
Sbjct: 522 -GVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFF 580
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V E+ P +TV V++ TD+D G N +T S+ ++ N FV++P +G I +N
Sbjct: 581 VSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---------FVLDPYSGVIKSNV 631
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDA 594
DRE S Y V A DGG P S T V I+V+DVNDN PV + + A
Sbjct: 632 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 691
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
+ G+ V++V A D D G+N + Y + +G F IDP +G I + V H
Sbjct: 692 IPGSVVAEVFAVDVDTGMNAELKYTI-VSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR 750
Query: 655 LKAVAIDGGTPPQSST-VIVHIKIED 679
L D G P T V+V + + D
Sbjct: 751 LVVNISDLGYPKSLHTLVLVFLYVND 776
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 239 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 298
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 299 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 337
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 338 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 397
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 398 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 454
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 455 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 510
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 511 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 568
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 569 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 626
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 627 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 685
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 686 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 738
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 739 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 161 bits (390), Expect = 4e-38
Identities = 130/453 (28%), Positives = 208/453 (45%), Gaps = 33/453 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++I + D N+ AP+F + S+ E+ I + + SATD D G N Y L ++
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL---LNG 184
Query: 515 EAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
++V D V P+ + + LDRE Y++ + DGG P S T ++++V
Sbjct: 185 QSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV 242
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK--DREEGS 629
DVNDN PVFK+ +I E+A VGTSV Q+ ATDAD+G N I Y + +
Sbjct: 243 SDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL 302
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
F ++ +G+I ++LDRE A H + +A DG + P +TV I + D+ND+PP +
Sbjct: 303 FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVT--INVTDVNDNPPNIDL 360
Query: 690 DCL------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
+ T Y+SE P+ T I I D D N V I + F L+
Sbjct: 361 RYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI---EREVPFHLKAVY-D 416
Query: 744 DKAELVTMVDLDYESPRK-KYELVIRAASPPLWNDVR-VEILVTDVNDNAPVMK----DF 797
++ L T LDYE ++ +++V + P N V + + D NDN P+ +
Sbjct: 417 NQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIEL 476
Query: 798 QIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNT 857
+ NN + + + A D D G NA+ L+ TG +T S +
Sbjct: 477 SVSENNRRGLY----LTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 858 NVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+ V+ D G +++ + V ++ E
Sbjct: 533 EEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 560 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 612
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 613 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 655
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 715
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 716 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 775
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 776 DTAGNASYIY 785
>AJ276803-1|CAC13122.1| 1037|Homo sapiens protocadherin protein.
Length = 1037
Score = 278 bits (682), Expect = 2e-73
Identities = 209/677 (30%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 95 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 154
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 155 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 210
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 211 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 270
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 271 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 328
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 329 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 388
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 389 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLENAAYLDY 447
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G ++
Sbjct: 448 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 507
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSATD+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 508 KVSATDADSGPNAEINYLLGPDAPPE--------FSLDRRTGMLTVVKKLDREKEDKYLF 559
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 560 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 619
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 620 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 676
Query: 670 TVIVHIKIEDINDSPPVFESDCLTF---YISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF + + ++ GT + ++ A D D G NA V YSI
Sbjct: 677 SAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 736
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 737 VGGNTRDLFAIDQETGN 753
Score = 262 bits (641), Expect = 2e-68
Identities = 202/687 (29%), Positives = 315/687 (45%), Gaps = 42/687 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 150 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 209
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 210 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 269
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 270 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 328
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 329 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 387
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 388 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA---- 443
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 444 ---YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 500
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G + +V ATDAD G N I+Y L P E F +D +G++ K LDRE +
Sbjct: 501 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYL 558
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 559 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 618
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 619 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 671
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG----RVPAYDAD--VTD 825
+ +V I V DVNDN PV + +Y+ P G +V A D D +
Sbjct: 672 VSRSSSAKVTINVVDVNDNKPVFIVPPYNY-SYELVLPSTNPGTVVFQVIAVDNDTGMNA 730
Query: 826 KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVR 885
+++Y I+ GN +L +++ TG++TL + + L + V D + V
Sbjct: 731 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVN 790
Query: 886 LITEEMLLNSITVRLNDMTAEQFLSPL 912
L E + N+ + N++ + +P+
Sbjct: 791 LFVNESVTNATLI--NELVRKSIEAPV 815
Score = 220 bits (537), Expect = 7e-56
Identities = 172/613 (28%), Positives = 281/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 257 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 315
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 316 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 355
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 356 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 415
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++ LDYE + Y + + A D G P + +
Sbjct: 416 RVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 472
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G +++V A DAD G NAE+ Y +
Sbjct: 473 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP---- 528
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 529 -DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 587
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y+ + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 588 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 645
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF PY S
Sbjct: 646 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYEL 705
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 706 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 758
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +I
Sbjct: 759 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSIEAPVTP 817
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 818 NTEIADVSSPTSD 830
Score = 167 bits (407), Expect = 4e-40
Identities = 133/415 (32%), Positives = 197/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 146 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 202
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 262
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 263 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 322
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 323 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 380
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 381 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 436
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 437 FLLENAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 495
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 496 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLD 550
>AF332217-1|AAK13469.1| 1340|Homo sapiens protocadherin 11 protein.
Length = 1340
Score = 278 bits (682), Expect = 2e-73
Identities = 209/677 (30%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 106 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 165
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 166 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 221
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 222 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 281
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 282 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 339
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 340 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 399
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 400 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLENAAYLDY 458
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G ++
Sbjct: 459 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 518
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSATD+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 519 KVSATDADSGPNAEINYLLGPDAPPE--------FSLDRRTGMLTVVKKLDREKEDKYLF 570
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 571 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 630
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 631 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 687
Query: 670 TVIVHIKIEDINDSPPVFESDCLTF---YISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF + + ++ GT + ++ A D D G NA V YSI
Sbjct: 688 SAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 747
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 748 VGGNTRDLFAIDQETGN 764
Score = 262 bits (641), Expect = 2e-68
Identities = 202/687 (29%), Positives = 315/687 (45%), Gaps = 42/687 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 280
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 339
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 340 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 398
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA---- 454
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 455 ---YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 511
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G + +V ATDAD G N I+Y L P E F +D +G++ K LDRE +
Sbjct: 512 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYL 569
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 570 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 629
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 630 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 682
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG----RVPAYDAD--VTD 825
+ +V I V DVNDN PV + +Y+ P G +V A D D +
Sbjct: 683 VSRSSSAKVTINVVDVNDNKPVFIVPPYNY-SYELVLPSTNPGTVVFQVIAVDNDTGMNA 741
Query: 826 KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVR 885
+++Y I+ GN +L +++ TG++TL + + L + V D + V
Sbjct: 742 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVN 801
Query: 886 LITEEMLLNSITVRLNDMTAEQFLSPL 912
L E + N+ + N++ + +P+
Sbjct: 802 LFVNESVTNATLI--NELVRKSIEAPV 826
Score = 220 bits (537), Expect = 7e-56
Identities = 172/613 (28%), Positives = 281/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 268 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 326
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 327 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 366
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 367 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 426
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++ LDYE + Y + + A D G P + +
Sbjct: 427 RVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 483
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G +++V A DAD G NAE+ Y +
Sbjct: 484 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP---- 539
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 540 -DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 598
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y+ + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 599 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 656
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF PY S
Sbjct: 657 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYEL 716
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 717 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 769
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +I
Sbjct: 770 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSIEAPVTP 828
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 829 NTEIADVSSPTSD 841
Score = 167 bits (407), Expect = 4e-40
Identities = 133/415 (32%), Positives = 197/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 157 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 213
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 273
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 274 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 333
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 334 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 391
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 447
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 448 FLLENAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 506
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 507 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLD 561
>AF332216-1|AAK13468.1| 1048|Homo sapiens protocadherin 11 protein.
Length = 1048
Score = 278 bits (682), Expect = 2e-73
Identities = 209/677 (30%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 106 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 165
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 166 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 221
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 222 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 281
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 282 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 339
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 340 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 399
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 400 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLENAAYLDY 458
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G ++
Sbjct: 459 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 518
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSATD+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 519 KVSATDADSGPNAEINYLLGPDAPPE--------FSLDRRTGMLTVVKKLDREKEDKYLF 570
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 571 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 630
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 631 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 687
Query: 670 TVIVHIKIEDINDSPPVFESDCLTF---YISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF + + ++ GT + ++ A D D G NA V YSI
Sbjct: 688 SAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 747
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 748 VGGNTRDLFAIDQETGN 764
Score = 262 bits (641), Expect = 2e-68
Identities = 202/687 (29%), Positives = 315/687 (45%), Gaps = 42/687 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 161 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 220
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 221 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 280
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 281 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 339
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 340 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 398
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 399 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA---- 454
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 455 ---YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 511
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G + +V ATDAD G N I+Y L P E F +D +G++ K LDRE +
Sbjct: 512 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYL 569
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 570 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 629
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 630 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 682
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG----RVPAYDAD--VTD 825
+ +V I V DVNDN PV + +Y+ P G +V A D D +
Sbjct: 683 VSRSSSAKVTINVVDVNDNKPVFIVPPYNY-SYELVLPSTNPGTVVFQVIAVDNDTGMNA 741
Query: 826 KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVR 885
+++Y I+ GN +L +++ TG++TL + + L + V D + V
Sbjct: 742 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVN 801
Query: 886 LITEEMLLNSITVRLNDMTAEQFLSPL 912
L E + N+ + N++ + +P+
Sbjct: 802 LFVNESVTNATLI--NELVRKSIEAPV 826
Score = 220 bits (537), Expect = 7e-56
Identities = 172/613 (28%), Positives = 281/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 268 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 326
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 327 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 366
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 367 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 426
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++ LDYE + Y + + A D G P + +
Sbjct: 427 RVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 483
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G +++V A DAD G NAE+ Y +
Sbjct: 484 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP---- 539
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 540 -DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 598
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y+ + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 599 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 656
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF PY S
Sbjct: 657 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYEL 716
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 717 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 769
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +I
Sbjct: 770 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSIEAPVTP 828
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 829 NTEIADVSSPTSD 841
Score = 167 bits (407), Expect = 4e-40
Identities = 133/415 (32%), Positives = 197/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 157 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 213
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 273
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 274 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 333
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 334 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 391
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 392 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 447
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 448 FLLENAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 506
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 507 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLD 561
>AF277053-1|AAL55729.1| 1037|Homo sapiens protocadherin-PC protein.
Length = 1037
Score = 278 bits (682), Expect = 2e-73
Identities = 209/677 (30%), Positives = 325/677 (48%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 95 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 154
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 155 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 210
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F
Sbjct: 211 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVF 270
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ + S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 271 KETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 328
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 329 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 388
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 389 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLENAAYLDY 447
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G ++
Sbjct: 448 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLM 507
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSATD+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 508 KVSATDADSGPNAEINYLLGPDAPPE--------FSLDRRTGMLTVVKKLDREKEDKYLF 559
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 560 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPD 619
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 620 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 676
Query: 670 TVIVHIKIEDINDSPPVFESDCLTF---YISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF + + ++ GT + ++ A D D G NA V YSI
Sbjct: 677 SAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 736
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 737 VGGNTRDLFAIDQETGN 753
Score = 262 bits (641), Expect = 2e-68
Identities = 202/687 (29%), Positives = 315/687 (45%), Gaps = 42/687 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 150 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 209
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 210 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPV 269
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 270 FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 328
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 329 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 387
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 388 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA---- 443
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 444 ---YLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 500
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G + +V ATDAD G N I+Y L P E F +D +G++ K LDRE +
Sbjct: 501 SPGIQLMKVSATDADSGPNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYL 558
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 559 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDP 618
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 619 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 671
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG----RVPAYDAD--VTD 825
+ +V I V DVNDN PV + +Y+ P G +V A D D +
Sbjct: 672 VSRSSSAKVTINVVDVNDNKPVFIVPPYNY-SYELVLPSTNPGTVVFQVIAVDNDTGMNA 730
Query: 826 KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVR 885
+++Y I+ GN +L +++ TG++TL + + L + V D + V
Sbjct: 731 EVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVN 790
Query: 886 LITEEMLLNSITVRLNDMTAEQFLSPL 912
L E + N+ + N++ + +P+
Sbjct: 791 LFVNESVTNATLI--NELVRKSIEAPV 815
Score = 220 bits (537), Expect = 7e-56
Identities = 172/613 (28%), Positives = 281/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 257 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 315
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 316 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 355
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 356 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 415
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++ LDYE + Y + + A D G P + +
Sbjct: 416 RVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 472
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G +++V A DAD G NAE+ Y +
Sbjct: 473 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP---- 528
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 529 -DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 587
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y+ + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 588 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 645
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF PY S
Sbjct: 646 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYEL 705
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 706 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 758
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +I
Sbjct: 759 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSIEAPVTP 817
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 818 NTEIADVSSPTSD 830
Score = 167 bits (407), Expect = 4e-40
Identities = 133/415 (32%), Positives = 197/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 146 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 202
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 262
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
NDN PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 263 TNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 322
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 323 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 380
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 381 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 436
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 437 FLLENAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 495
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 496 IPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLD 550
>AB053445-1|BAB61902.1| 1147|Homo sapiens KIAA1774 protein protein.
Length = 1147
Score = 277 bits (678), Expect = 6e-73
Identities = 216/698 (30%), Positives = 338/698 (48%), Gaps = 61/698 (8%)
Query: 96 SGALLTRASLDREKVARYTVLVKATDQASPVSDRLSST--ATIHVNIIDDNDNYPQFSEK 153
+G+++ ++ ++RE VA Y V + D AS + +R S A + VN++D NDN PQF
Sbjct: 65 TGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPF 124
Query: 154 TYTVSVDEDIS-VTDNPVIAKIKATDADVGANSAIRYAIIG----GNTQMQFSIDSLSGD 208
T ++ + T + + A D D G N + Y ++ G Q++ DS +G
Sbjct: 125 GITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE---DSSAGK 181
Query: 209 VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSE 268
V +T+DYE+V +RA D GSP R+ + + I D+NDN P F +QE+V E
Sbjct: 182 VIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFE 241
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRET 328
+VP+G I+ V A DAD G A + Y++ G+ + I+P +G +Y LDRE
Sbjct: 242 DVPVGTIILTVTATDADSGNFALIEYSL------GDGESKFAINPTTGDIYVLSSLDREK 295
Query: 329 QAKYQLLVTATDG-GDPP---RSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
+ Y L A D GD R + F Q+ + E+EP GT
Sbjct: 296 KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTS 355
Query: 385 VVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
V+T+ ATD DE + L Y + G F + + GL+T +PL + ++ LTV
Sbjct: 356 VITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDS--GLVTTQRPL--QSYEKFSLTVV 410
Query: 443 ATDSGGRS--DTAMVQINITDANNYAPVFENAP--YTASVFEDAPIGTTVLVVSATDSDV 498
ATD G T M+ + + D N+ PVF P + E+ P+ + V V ATD D
Sbjct: 411 ATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDE 470
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
G+N + YS N + F+I+P +G I T + LDRE+ + Y L + A D G
Sbjct: 471 GLNGAVRYSFLKTAGN----RDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 526
Query: 559 PSLSDTTD-VEISVVDVNDNEPVF------KQQLYTANIMEDALVGTSVSQV-GATDADV 610
P +T +++++ D++DNEP+F Q + E + GT V V GA DAD
Sbjct: 527 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE 586
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALD--RESVATHDLKAVAIDGGTPPQ- 667
G N ++Y + EE +F + P G + + LD RE++ + +KA + TPP+
Sbjct: 587 GPNAIVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRG 644
Query: 668 -SSTV---------IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
S T+ V + +EDIND PP F T ++ ++ +G+ + ++ A D D G
Sbjct: 645 PSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIG 704
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD 755
N++V YSI + F D ++ TM +D
Sbjct: 705 NNSLVFYSILA---IHYFRALANDSEDVGQVFTMGSMD 739
Score = 232 bits (567), Expect = 2e-59
Identities = 201/647 (31%), Positives = 307/647 (47%), Gaps = 79/647 (12%)
Query: 11 INVLDCNDHSPVFE---MQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI-ELVT 66
+NVLD ND++P F+ + Y + EGA+ GTT++ + A D D G N V YT+ +LV
Sbjct: 109 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP 168
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
+ ED+ +G ++ ++D E+V V+A+D SP
Sbjct: 169 PGYVQLEDSS-------------------AGKVIANRTVDYEEVHWLNFTVRASDNGSPP 209
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
++ +++ I+D NDN P F + +Y +V ED+ V +I + ATDAD G +
Sbjct: 210 R---AAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV--GTIILTVTATDADSGNFAL 264
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDG----GSPSRSNTTQ 242
I Y++ G+ + +F+I+ +GD+ ++ +LD E+ Y L A+D S R N+ Q
Sbjct: 265 IEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQ 322
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
++I + DVND P+F F SV EN P G S++ + A D DEG N ELTY++
Sbjct: 323 VVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE 382
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+D SG V T L ++ K+ L V ATDGG+PP T
Sbjct: 383 A-----FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDN 435
Query: 363 XXXFM--PGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI--TGGNTRGRFSITS 416
F+ P + + E+ P + V + ATD DE + + Y T GN F I
Sbjct: 436 RPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIID 495
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG---GRSDTAMVQINITDANNYAPVFENAP 473
GLI AQ LD + + Y L + A+D G +Q+ + D ++ P+F P
Sbjct: 496 PIS-GLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 554
Query: 474 ------YTASVFEDAPIGTTV-LVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
+V E +P GT V V A D+D G NA + Y + A + ++ F +
Sbjct: 555 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI-------AAGNEEKNFHL 607
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARD--------GGVPSL---SDTTDVEISVV--D 573
P G + + LDRE + + V A G P+L +D T E+ VV D
Sbjct: 608 QPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLED 666
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL 620
+ND P F + YTA + DA VG+ + QV A DAD+G N + Y +
Sbjct: 667 INDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 713
Score = 199 bits (485), Expect = 1e-49
Identities = 181/631 (28%), Positives = 291/631 (46%), Gaps = 74/631 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ ++D ND++P+F+ Y+ +V E GT +LT+ ATD D G A +EY++
Sbjct: 218 LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLG------- 270
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV-SDR 129
D + F I+ +G + +SLDREK Y + A D V S+R
Sbjct: 271 ---DG-----------ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 316
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + + ++D ND PQFS+ ++ SV E+ + + + ATD D G N + Y
Sbjct: 317 RENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTS--VITMMATDQDEGPNGELTY 374
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
++ G + F +D SG V+ + L + + L + A DGG P TT LL+ + D
Sbjct: 375 SLEGPGVE-AFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVID 431
Query: 250 VNDNAPRFYTSLFQE--SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
VNDN P F + E +P+ ++ V A D DEG+N + Y+ GN D
Sbjct: 432 VNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT--AGNRDW 489
Query: 308 P-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP-PRSATATXXXXXXXXXXXXXX 365
IDP SG + T+ +LDRE+QA Y L++ A+D G P P
Sbjct: 490 EFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPL 549
Query: 366 FM-----PGQYE-VELAEDEPPGTPVVTLT-ATDADEDNR--LHYEITGGNTRGRFSITS 416
F+ QY+ + + E P GT V +T A DADE ++Y I GN F +
Sbjct: 550 FVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP 609
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSA------TDSGGRSDT---------AMVQINITD 461
G + V + LD ++E + V A T G S T V++ + D
Sbjct: 610 D---GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLED 666
Query: 462 ANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHD 521
N+ P F A YTA V DA +G+ ++ V A D+D+G N+ + YS+ + A+A+
Sbjct: 667 INDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDS 726
Query: 522 ----QQFVINPQTGAITTNKLLDRETMSGYLLTVTARD--G-------GVPSLSDTTDVE 568
Q F + G + T L + +++ + ARD G G+ L D V+
Sbjct: 727 EDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVK 786
Query: 569 ISVVDVNDNEPVFKQQ-LYTANIMEDALVGT 598
I + ++ D F+++ ++ + + A+V T
Sbjct: 787 IVINEIPDRVRGFEEEFIHLLSNITGAIVNT 817
Score = 169 bits (410), Expect = 2e-40
Identities = 128/409 (31%), Positives = 193/409 (47%), Gaps = 36/409 (8%)
Query: 402 EITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG----RS---DTAM 454
+I GG+++ + G + V P++ + Y +T+S D+ RS A
Sbjct: 49 QILGGSSQAEPGLVWSTGS--VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAK 106
Query: 455 VQINITDANNYAPVFEN---APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSE 511
+ +N+ D N+ P F+ Y + E A GTT++ V+A D D G+N +TY+L
Sbjct: 107 LTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDL 166
Query: 512 ISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISV 571
+ V D G + N+ +D E + TV A D G P + V + +
Sbjct: 167 VPPGYVQLEDSS------AGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 220
Query: 572 VDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV 631
VD+NDN P+F Q Y + ED VGT + V ATDAD G I Y L E F
Sbjct: 221 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG---ESKFA 277
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDG----GTPPQSSTVIVHIKIEDINDSPPVF 687
I+P +G I +LDRE + L A+A D + + ++V V I++ D+ND P F
Sbjct: 278 INPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF 337
Query: 688 ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE 747
+ + EN P GT++ + A D DEGPN + YS++G +F ++ G
Sbjct: 338 SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEAFHVDMDSG----- 391
Query: 748 LVTMVDLDYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPV 793
LVT +S +K+ L + A PPLW + + V DVNDN PV
Sbjct: 392 LVT-TQRPLQS-YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPV 438
Score = 39.5 bits (88), Expect = 0.17
Identities = 21/56 (37%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 9 QQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
Q++ V+ D ND P F +Y A V A G+ ++ + A D DIG N+ V Y+I
Sbjct: 658 QEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 713
>AF217288-1|AAK82656.1| 1310|Homo sapiens protocadherin-S protein.
Length = 1310
Score = 276 bits (676), Expect = 1e-72
Identities = 209/677 (30%), Positives = 323/677 (47%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D N N P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDPNANHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (641), Expect = 2e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDPNANHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 210 bits (514), Expect = 4e-53
Identities = 169/613 (27%), Positives = 277/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D N + PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDPNANHPVFKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 164 bits (399), Expect = 4e-39
Identities = 133/415 (32%), Positives = 197/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
N N PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 PNANHPVFKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AF206516-1|AAK82655.1| 1347|Homo sapiens protocadherin-S protein.
Length = 1347
Score = 276 bits (676), Expect = 1e-72
Identities = 209/677 (30%), Positives = 323/677 (47%), Gaps = 40/677 (5%)
Query: 89 VFRIDGRSGALLTR-ASLDREKVARYTVLVKATDQASPVS---DRLSSTATIHVNIIDDN 144
+ RI+ +G + T A +DREK+ + V+ D + I I D N
Sbjct: 74 LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN 133
Query: 145 DNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS 204
DN P F +S+ E+ ++ + A D DVG N Y +I +Q F +D
Sbjct: 134 DNAPLFPATVINISIPENSAINSKYTLPA--AVDPDVGINGVQNYELI--KSQNIFGLDV 189
Query: 205 LS---GD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRF 257
+ GD + + K LD E+ +Y + ++ +DGG P RS+T L +++ D N N P F
Sbjct: 190 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDPNANHPVF 249
Query: 258 YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSG 316
+ S+ EN P+G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G
Sbjct: 250 KEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTG 307
Query: 317 WVYTSGQLDRETQAKYQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYE 372
+ LDRE ++LLV A+DGG P A T P
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 373 VELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDF 431
V L+E+ P T + +T TD D D+ T R N + L+ A LD+
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDY 426
Query: 432 KQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVL 489
+ + Y + + A D+G + +AM+ I + D N+ APVF + T S+ E+ G +
Sbjct: 427 ESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLT 486
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
VSA D+D G NA+I Y L + E F ++ +TG +T K LDRE YL
Sbjct: 487 KVSAMDADSGPNAKINYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLF 538
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
T+ A+D GVP L+ V +S++D NDN PVF Y + E+ +V + TD D
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPD 598
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + L D E F ID +GVIR N + DRE ++ A DGG +SS
Sbjct: 599 YGDNSAV--TLSILD-ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSS 655
Query: 670 TVIVHIKIEDINDSPPVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
+ V I + D+ND+ PVF S+C + ++ GT + ++ A D D G NA V YSI
Sbjct: 656 SAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSI 715
Query: 727 KGGDDSNSFSLETRQGS 743
GG+ + F+++ G+
Sbjct: 716 VGGNTRDLFAIDQETGN 732
Score = 262 bits (641), Expect = 2e-68
Identities = 204/689 (29%), Positives = 319/689 (46%), Gaps = 46/689 (6%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I D+NDNAP F ++ S+ EN I A D D G+N Y + +D
Sbjct: 129 IEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLD 188
Query: 307 LPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+ T + + + +LDRE + Y + V DGG P RS+TA
Sbjct: 189 VIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDPNANHPV 248
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGR 420
F + EV + E+ P GT V L ATDAD E+ ++H+ + R F + + G
Sbjct: 249 FKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG- 307
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPY 474
LIT+ +PLD ++ + L V A+D G AMV +N+TD N+ P +
Sbjct: 308 -LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVND 366
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
T + E+ P+ T + +++ TD D N ++T EI QF++
Sbjct: 367 TVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE------- 419
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T LD E+ Y + + A D G P L+ + + I V D NDN PVF Q T +I E+
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENN 479
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
G +++V A DAD G N +I+Y L P E F +D +G++ K LDRE +
Sbjct: 480 SPGIQLTKVSAMDADSGPNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYL 537
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDP 714
+A D G PP +S V V + I D ND+ PVF + FY+ EN P T+G I DP
Sbjct: 538 FTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDP 597
Query: 715 DEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---AS 771
D G N+ V SI D+++ F+++++ G + + D E ++ Y ++A
Sbjct: 598 DYGDNSAVTLSIL--DENDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGR 650
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--V 823
+ +V I V DVNDN PV F + +N Y+ P G +V A D D +
Sbjct: 651 VSRSSSAKVTINVVDVNDNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGM 707
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLS 883
+++Y I+ GN +L +++ TG++TL + + L + V D +
Sbjct: 708 NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Query: 884 VRLITEEMLLNSITVRLNDMTAEQFLSPL 912
V L E + N+ + N++ + +P+
Sbjct: 768 VNLFVNESVTNATLI--NELVRKSTEAPV 794
Score = 210 bits (514), Expect = 4e-53
Identities = 169/613 (27%), Positives = 277/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D N + PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 236 QVSVTDPNANHPVFKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 294
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 295 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 334
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 335 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 394
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 395 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 451
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 452 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 507
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 508 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 566
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 567 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 624
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 625 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 684
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 685 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 737
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 738 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 796
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 797 NTEIADVSSPTSD 809
Score = 164 bits (399), Expect = 4e-39
Identities = 133/415 (32%), Positives = 197/415 (47%), Gaps = 23/415 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
++ I D N+ AP+F S+ E++ I + + +A D DVGIN Y L I +
Sbjct: 125 IRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYEL---IKS 181
Query: 515 EAVAHHDQ-QFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ + D + + + K LDRE Y++ V DGG P S T +++SV D
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTD 241
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFV 631
N N PVFK+ +I E+A VGTSV+Q+ ATDAD+G N +IH+ + F
Sbjct: 242 PNANHPVFKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFH 301
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
++ +G+I + LDRE H L +A DGG P + V+V+ + D+ND+ P +
Sbjct: 302 LNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRY 359
Query: 692 L------TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK 745
+ T +SEN P+ T I I D D N V D F L S++
Sbjct: 360 IVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQ 415
Query: 746 AELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
L T LDYES K+Y + + AA PPL + I V D NDNAPV + +
Sbjct: 416 FLLETAAYLDYES-TKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVS 474
Query: 803 NYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
++ P +V A DAD + L G +A L+ TG +T+ +L+
Sbjct: 475 IPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 529
>AL731541-3|CAI40838.1| 728|Homo sapiens cadherin-like 23 protein.
Length = 728
Score = 274 bits (673), Expect = 2e-72
Identities = 194/640 (30%), Positives = 302/640 (47%), Gaps = 43/640 (6%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D F +D +G ++ A LD E + R+T+ + A D +T + +N++D NDN
Sbjct: 21 DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE-----ETTGRVRINVLDVNDNV 75
Query: 148 PQFSEKTYTVSVDE-DISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSID 203
P F + Y ++ E + SVT + +++ATD D N+ I Y+I+ + + S+
Sbjct: 76 PTFQKDAYVGALRENEPSVTQ---LVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 132
Query: 204 SLSGDVSLVKTLDYEQVRS--YRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
G +S+ + LDYEQ+ + L + A D G+P ++T + I + D NDN P F
Sbjct: 133 EGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPA 192
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+ SV EN+ G +++ + A D D Y Y+ I+ RSG + T+
Sbjct: 193 YFVSVVENIMAGATVLFLNATDLDR----SREYGQESIIYSLEGSTQFRINARSGEITTT 248
Query: 322 GQLDRETQAKYQLLVTATDG--GDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
LDRET+++Y L+V A DG G ++ AT + Y + L E
Sbjct: 249 SLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 308
Query: 380 PPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR-----GLITVAQPLDFK 432
PP + V T+ A D D E+ L Y I N +S+ S G+ ++ P +
Sbjct: 309 PPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHE 366
Query: 433 QERRYVLTVSATDSG----GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTV 488
E + VS TD G + +A V +N+ D N+ P F+N P+ A V E P G ++
Sbjct: 367 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 426
Query: 489 LVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYL 548
V A D D G+N ++Y + V F+IN +G + T LDRE ++ Y
Sbjct: 427 YQVVAIDLDEGLNGLVSYRM-------PVGMPRMDFLINSSSGVVVTTTELDRERIAEYQ 479
Query: 549 LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDA 608
L V A D G P+ S T+ + I V+DVND P F +Y ++ ED V + TD
Sbjct: 480 LRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDN 539
Query: 609 DVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGT--PP 666
DVGLN + Y + +G F + V+RT LDRE+ A + L AID G
Sbjct: 540 DVGLNAELSYFI-TGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKR 598
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
+ T V + + D+ND+ P+F + E+ P G +I
Sbjct: 599 HTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 638
Score = 270 bits (663), Expect = 4e-71
Identities = 203/640 (31%), Positives = 309/640 (48%), Gaps = 44/640 (6%)
Query: 176 ATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSP 235
ATD D G + Y + +FS+D +G + L+ LDYE ++ + L I A+DGG
Sbjct: 1 ATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG- 57
Query: 236 SRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT 295
T ++ IN+ DVNDN P F + ++ EN P +VR++A D D N ++TY+
Sbjct: 58 -EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYS 116
Query: 296 MTDKDYTGNVDLPITIDPRSGWVYTSGQLDRE--TQAKYQLLVTATDGGDPPRSATATXX 353
+ G+ I++ G + S LD E + L V A D G+PP ++T
Sbjct: 117 IVSASAFGSY-FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVT 175
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG--R 411
F Y V + E+ G V+ L ATD D E + G +
Sbjct: 176 IEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ 235
Query: 412 FSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG-GRSD-TAMVQINIT--DANNYAP 467
F I +++G IT LD + + Y+L V A D G G + T + +NIT D N+ P
Sbjct: 236 FRINARSGE--ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHP 293
Query: 468 VFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+++APY ++ E P + V V A D D+G N + YS+ ++ + +N
Sbjct: 294 TWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP---------NKFYSLN 344
Query: 528 PQTGAI-TTNKLLDRETMSGY------LLTVTARDGGVPSLSDTTD--VEISVVDVNDNE 578
TG I TT+ +LDRE + + V+ D G P L T+ V ++++D+NDN+
Sbjct: 345 STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDND 404
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
P F+ + A ++E G S+ QV A D D GLNG + Y + P F+I+ +SGV
Sbjct: 405 PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGMPRMDFLINSSSGV 463
Query: 639 IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISE 698
+ T LDRE +A + L+ VA D GTP +SST + I + D+ND P F +SE
Sbjct: 464 VVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSE 523
Query: 699 NSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYES 758
+ P + + D D G NA + Y I GG+ FS+ G A + T+V LD E+
Sbjct: 524 DVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV----GYRDAVVRTVVGLDRET 579
Query: 759 PRKKYELVIRAA-SPPL----WNDVRVEILVTDVNDNAPV 793
Y L++ A + P+ V + V DVNDN P+
Sbjct: 580 -TAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPI 618
Score = 229 bits (561), Expect = 8e-59
Identities = 181/607 (29%), Positives = 282/607 (46%), Gaps = 45/607 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+INVLD ND+ P F+ Y ++RE S T ++ L+ATD+D N ++ Y+I V+A
Sbjct: 65 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI--VSASA 122
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVL--VKATDQASPVS 127
D+ +G G + LD E+++ + V A D +P
Sbjct: 123 FG-------------SYFDISLYEGY-GVISVSRPLDYEQISNGLIYLTVMAMDAGNPP- 167
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ST + + + D+NDN P FS+ Y VSV E+I + + ATD D
Sbjct: 168 --LNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA--GATVLFLNATDLDRSREYGQ 223
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I QF I++ SG+++ LD E Y L++RA DGG T +NI
Sbjct: 224 ESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNI 283
Query: 248 R--DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT--DKDYTG 303
D+NDN P + + + ++ E P + V A D D G N L Y++ +K Y+
Sbjct: 284 TLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL 343
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSAT--ATXXXXXXXXXX 361
N I + E + +++V+ TD G PP AT AT
Sbjct: 344 NSTTG-KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 402
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNG 419
F + E+ E P G + + A D DE + + Y + G R F I S +G
Sbjct: 403 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG 462
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTAS 477
++ LD ++ Y L V A+D+G +S T+ + I++ D N+ P F A Y S
Sbjct: 463 --VVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 520
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V ED P V+ ++ TD+DVG+NA+++Y ++ + D +F + + + T
Sbjct: 521 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITG-------GNVDGKFSVGYRDAVVRTVV 573
Query: 538 LLDRETMSGYLLTVTARDGGVPSL--SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
LDRET + Y+L + A D G + T V ++V+DVNDN P+F Q Y A++ ED
Sbjct: 574 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIP 633
Query: 596 VGTSVSQ 602
G S+ Q
Sbjct: 634 EGHSILQ 640
Score = 135 bits (326), Expect = 2e-30
Identities = 134/453 (29%), Positives = 204/453 (45%), Gaps = 54/453 (11%)
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD+D G +++Y S + +F ++ TG I LD E + + LT+
Sbjct: 1 ATDNDAGTFGEVSYFFSDD---------PDRFSLDKDTGLIMLIARLDYELIQRFTLTII 51
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
ARDGG T V I+V+DVNDN P F++ Y + E+ T + ++ ATD D
Sbjct: 52 ARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP 109
Query: 613 NGRIHYELDPKDREEGSFVID--PASGVIRTNKALDRESVATH--DLKAVAIDGGTPPQS 668
N +I Y + F I GVI ++ LD E ++ L +A+D G PP +
Sbjct: 110 NNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLN 169
Query: 669 STVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE----GPNAVVHY 724
STV V I++ D ND+PP F + EN G T+ + A D D G +++ Y
Sbjct: 170 STVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-Y 228
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVR----- 779
S++G S F + R G E+ T LD E+ + +Y L++RA + ++ +
Sbjct: 229 SLEG---STQFRINARSG----EITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIAT 280
Query: 780 VEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK--LQYRILSGNNA 837
V I + D+NDN P KD N + P V A D D+ + L Y I N
Sbjct: 281 VNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-- 338
Query: 838 NLILLNETTGSM-TLSPQLNTNVPK------LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
LN TTG + T L+ P + + VSVTD G +KA +V
Sbjct: 339 KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV----- 393
Query: 890 EMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAA 922
+N + + ND T + P + ++G+ A
Sbjct: 394 --FVNLLDLNDNDPTFQNL--PFVAEVLEGIPA 422
>BC051788-1|AAH51788.1| 929|Homo sapiens protocadherin gamma
subfamily B, 7 protein.
Length = 929
Score = 273 bits (669), Expect = 7e-72
Identities = 179/605 (29%), Positives = 287/605 (47%), Gaps = 25/605 (4%)
Query: 197 QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAP 255
++ FS+D+ SGD+ + +D EQ+ R Q + + N +++ I DVND+AP
Sbjct: 72 KLHFSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAP 131
Query: 256 RFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRS 315
+F +SE+V +G + A D D +N+ Y ++ +Y V+ +
Sbjct: 132 QFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKY 191
Query: 316 GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVEL 375
+ LDRETQ+ + L++TA DGGDPPRS TA F Y V L
Sbjct: 192 PELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSL 251
Query: 376 AEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQ 433
ED PPGT ++ + ATD DE ++ + Y G + + + G I QPLDF++
Sbjct: 252 REDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEE 311
Query: 434 ERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSA 493
RY + + A D G S V + + D N+ +P + + ED+P G V +
Sbjct: 312 VERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKT 371
Query: 494 TDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D D G N ++ SLS + + + + + + T++ LDRE Y +T+ A
Sbjct: 372 RDQDSGENGEVRCSLSRGVPFKIHSSSNNYY-------KLVTDEALDREQTPEYNVTIAA 424
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D G P LS + + + + DVNDN PVF Q Y ++ E+ G S++QV A+D D GLN
Sbjct: 425 TDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLN 484
Query: 614 GRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GR+ Y L D + R S+V + SGV+ +A D E + T +L A D G+P S+
Sbjct: 485 GRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSA 544
Query: 670 TVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
V + + + D ND+ P + L + + G + ++ A D D G NA +
Sbjct: 545 NVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWL 604
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWNDVRVE 781
Y + + FSL R G + +V + D +S R++ + +R PPL +
Sbjct: 605 SYHVVQASEPGLFSLGLRTG--EVRMVRALG-DKDSVRQRLLVAVRDGGQPPLSATATLH 661
Query: 782 ILVTD 786
++ D
Sbjct: 662 LVFAD 666
Score = 245 bits (599), Expect = 2e-63
Identities = 188/610 (30%), Positives = 299/610 (49%), Gaps = 38/610 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F +D +SG LL + +DRE++ + + Q V + + + V I D ND+ PQ
Sbjct: 75 FSVDAQSGDLLVKDRIDREQICKERRRCEL--QLEAVVENPLNIFHVIVVIEDVNDHAPQ 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F + + + E +S+ ++ A D D+ NS +Y + D+ G
Sbjct: 133 FRKDEINLEISESVSLGMGTILES--AEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L KTLD E ++ LV+ A DGG P RS T Q+ I + D NDN P F +++ S
Sbjct: 191 YPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E+VP G SI+RV+A D DEG+N+E+TY+ ++D +G + T LD
Sbjct: 251 LREDVPPGTSILRVKATDQDEGINSEITYSFF--GVADKAQHVFSLDYTTGNILTQQPLD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y + + A D G S + ++ ED PPG V
Sbjct: 309 FEEVERYTINIEAKDRGS--LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGV-V 365
Query: 386 VTLTATDADEDNRLHYEITGGNTRG-RFSI-TSQNGRGLITVAQPLDFKQERRYVLTVSA 443
V L T D+D+ + E+ +RG F I +S N + + LD +Q Y +T++A
Sbjct: 366 VALFKT-RDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAA 424
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G S + + ++ITD N+ APVF + Y V E+ G ++ VSA+D D G+N
Sbjct: 425 TDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLN 484
Query: 502 AQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
+++YSL +S++ + ++ + ++ Q+G + + D E + + LT+ ARD G P+
Sbjct: 485 GRVSYSLIASDLESRTLSSY---VSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPA 541
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDADV 610
LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 542 LSANVSLRVLVGDRNDNAP---RVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADS 598
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKAL-DRESVATHDLKAVAIDGGTPPQSS 669
G N + Y + + E G F + +G +R +AL D++SV L AV DGG PP S+
Sbjct: 599 GHNAWLSYHV-VQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVR-DGGQPPLSA 656
Query: 670 TVIVHIKIED 679
T +H+ D
Sbjct: 657 TATLHLVFAD 666
Score = 196 bits (478), Expect = 9e-49
Identities = 167/588 (28%), Positives = 268/588 (45%), Gaps = 61/588 (10%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F + + E S G + A D DI N+ +Y
Sbjct: 118 HVIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + V+ G+ L+ + +LDRE + + +++ A D P
Sbjct: 171 -QLSPNE-------YFSLVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPPR 222
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
S TA I + +ID NDN P FS+ Y VS+ ED V I ++KATD D G NS I
Sbjct: 223 ---SGTAQIRILVIDANDNPPVFSQDVYRVSLRED--VPPGTSILRVKATDQDEGINSEI 277
Query: 188 RYAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y+ G Q FS+D +G++ + LD+E+V Y + I A+D G S S ++++
Sbjct: 278 TYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEVERYTINIEAKDRG--SLSTRCKVIV 335
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
+ D NDN+P + + + E+ P G + + D D G N E+ +++
Sbjct: 336 EVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSR------- 388
Query: 306 DLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+P I S Y T LDRE +Y + + ATD G PP S++ T
Sbjct: 389 GVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDN 448
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR-----FSIT 415
F Y V + E+ PG + ++A+D D + R+ Y + + R S++
Sbjct: 449 APVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVS 508
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA 472
+Q+ G++ + D +Q R + LT+ A D G + +A V + + D N+ AP V A
Sbjct: 509 AQS--GVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPA 566
Query: 473 --PYTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
P +++F+ P G V V A D+D G NA ++Y + A F +
Sbjct: 567 LGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHV-------VQASEPGLFSL 619
Query: 527 NPQTGAITTNKLL-DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+TG + + L D++++ LL V RDGG P LS T + + D
Sbjct: 620 GLRTGEVRMVRALGDKDSVRQRLL-VAVRDGGQPPLSATATLHLVFAD 666
Score = 192 bits (469), Expect = 1e-47
Identities = 149/468 (31%), Positives = 223/468 (47%), Gaps = 30/468 (6%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD + + + L ++A D G RS TA ++I + DAN+ PVF Y S+ E
Sbjct: 194 LVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLRE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
D P GT++L V ATD D GIN++ITYS ++++A F ++ TG I T + LD
Sbjct: 254 DVPPGTSILRVKATDQDEGINSEITYSFFG-VADKA----QHVFSLDYTTGNILTQQPLD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A+D G SLS V + VVD NDN P + IMED+ G V
Sbjct: 309 FEEVERYTINIEAKDRG--SLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVV 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ D D G NG + L F I +S + T++ALDRE +++
Sbjct: 367 ALFKTRDQDSGENGEVRCSLS----RGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTI 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D G PP SS+ + + I D+ND+ PVF ++ EN+ G +I ++ A DPD G
Sbjct: 423 AATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFG 482
Query: 718 PNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N V YS+ D +S + S + + D+E R +EL ++A SP
Sbjct: 483 LNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLR-TFELTLQARDQGSPA 541
Query: 774 LWNDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
L +V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 542 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHN 601
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y ++ + L L TG + + L + V+V DG
Sbjct: 602 AWLSYHVVQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVRDG 649
Score = 176 bits (429), Expect = 8e-43
Identities = 144/472 (30%), Positives = 221/472 (46%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V+D ND+ PVF Y S+RE GT++L +KATDQD G N+E+ Y+ V AD
Sbjct: 229 RILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGV-ADK 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
Q VF +D +G +LT+ LD E+V RYT+ ++A D+ S
Sbjct: 288 ----------------AQHVFSLDYTTGNILTQQPLDFEEVERYTINIEAKDRGS----- 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
LS+ + V ++D+NDN P+ + + + ED V+A K D D G N +R
Sbjct: 327 LSTRCKVIVEVVDENDNSPEIIITSLSDQIMED--SPPGVVVALFKTRDQDSGENGEVRC 384
Query: 190 AIIGGNTQMQFSIDSLSGD-VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++ G + F I S S + LV + LD EQ Y + I A D G P S++ + ++
Sbjct: 385 SLSRG---VPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDRGKPPLSSSKTITLH 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY-TGNV 305
I DVNDNAP F S + V EN G SI +V A D D G+N ++Y++ D + +
Sbjct: 442 ITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ +SG V+ D E ++L + A D G P SA +
Sbjct: 502 SSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPR 561
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 562 VLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGLFSLGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + + + L K R L V+ D G +A +++ A++ V
Sbjct: 622 RTGE--VRMVRALGDKDSVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 671
Score = 119 bits (287), Expect = 1e-25
Identities = 84/276 (30%), Positives = 132/276 (47%), Gaps = 12/276 (4%)
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFK 582
F ++ Q+G + +DRE + + + V + + V + + DVND+ P F+
Sbjct: 75 FSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFR 134
Query: 583 QQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV---I 639
+ I E +G A D D+ +N Y+L P + +P G +
Sbjct: 135 KDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPEL 194
Query: 640 RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
K LDRE+ + H L A+DGG PP+S T + I + D ND+PPVF D + E+
Sbjct: 195 VLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLRED 254
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDLDYE 757
P GT+I ++A D DEG N+ + YS G D + FSL+ G+ ++T LD+E
Sbjct: 255 VPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGN----ILTQQPLDFE 310
Query: 758 SPRKKYELVIRAAS-PPLWNDVRVEILVTDVNDNAP 792
++Y + I A L +V + V D NDN+P
Sbjct: 311 EV-ERYTINIEAKDRGSLSTRCKVIVEVVDENDNSP 345
>AY563166-1|AAT72166.1| 1079|Homo sapiens cadherin 23 isoform B2
protein.
Length = 1079
Score = 273 bits (669), Expect = 7e-72
Identities = 215/694 (30%), Positives = 334/694 (48%), Gaps = 61/694 (8%)
Query: 100 LTRASLDREKVARYTVLVKATDQASPVSDRLSST--ATIHVNIIDDNDNYPQFSEKTYTV 157
+ ++ ++RE VA Y V + D AS + +R S A + VN++D NDN PQF T
Sbjct: 1 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 60
Query: 158 SVDEDIS-VTDNPVIAKIKATDADVGANSAIRYAIIG----GNTQMQFSIDSLSGDVSLV 212
++ + T + + A D D G N + Y ++ G Q++ DS +G V
Sbjct: 61 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE---DSSAGKVIAN 117
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
+T+DYE+V +RA D GSP R+ + + I D+NDN P F +QE+V E+VP+
Sbjct: 118 RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV 177
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKY 332
G I+ V A DAD G A + Y++ G+ + I+P +G +Y LDRE + Y
Sbjct: 178 GTIILTVTATDADSGNFALIEYSL------GDGESKFAINPTTGDIYVLSSLDREKKDHY 231
Query: 333 QLLVTATDG-GDPP---RSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTL 388
L A D GD R + F Q+ + E+EP GT V+T+
Sbjct: 232 ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITM 291
Query: 389 TATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
ATD DE + L Y + G F + + GL+T +PL + ++ LTV ATD
Sbjct: 292 MATDQDEGPNGELTYSLEGPGVEA-FHVDMDS--GLVTTQRPL--QSYEKFSLTVVATDG 346
Query: 447 GGRS--DTAMVQINITDANNYAPVFENAP--YTASVFEDAPIGTTVLVVSATDSDVGINA 502
G T M+ + + D N+ PVF P + E+ P+ + V V ATD D G+N
Sbjct: 347 GEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNG 406
Query: 503 QITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
+ YS N + F+I+P +G I T + LDRE+ + Y L + A D G P
Sbjct: 407 AVRYSFLKTAGN----RDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY 462
Query: 563 DTTD-VEISVVDVNDNEPVF------KQQLYTANIMEDALVGTSVSQV-GATDADVGLNG 614
+T +++++ D++DNEP+F Q + E + GT V V GA DAD G N
Sbjct: 463 ETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNA 522
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALD--RESVATHDLKAVAIDGGTPPQ--SST 670
++Y + EE +F + P G + + LD RE++ + +KA + TPP+ S T
Sbjct: 523 IVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT 580
Query: 671 V---------IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAV 721
+ V + +EDIND PP F T ++ ++ +G+ + ++ A D D G N++
Sbjct: 581 LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL 640
Query: 722 VHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD 755
V YSI + F D ++ TM +D
Sbjct: 641 VFYSILA---IHYFRALANDSEDVGQVFTMGSMD 671
Score = 232 bits (567), Expect = 2e-59
Identities = 201/647 (31%), Positives = 307/647 (47%), Gaps = 79/647 (12%)
Query: 11 INVLDCNDHSPVFE---MQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI-ELVT 66
+NVLD ND++P F+ + Y + EGA+ GTT++ + A D D G N V YT+ +LV
Sbjct: 41 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP 100
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
+ ED+ +G ++ ++D E+V V+A+D SP
Sbjct: 101 PGYVQLEDSS-------------------AGKVIANRTVDYEEVHWLNFTVRASDNGSPP 141
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
++ +++ I+D NDN P F + +Y +V ED+ V +I + ATDAD G +
Sbjct: 142 R---AAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV--GTIILTVTATDADSGNFAL 196
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDG----GSPSRSNTTQ 242
I Y++ G+ + +F+I+ +GD+ ++ +LD E+ Y L A+D S R N+ Q
Sbjct: 197 IEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQ 254
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
++I + DVND P+F F SV EN P G S++ + A D DEG N ELTY++
Sbjct: 255 VVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE 314
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+D SG V T L ++ K+ L V ATDGG+PP T
Sbjct: 315 A-----FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDN 367
Query: 363 XXXFM--PGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI--TGGNTRGRFSITS 416
F+ P + + E+ P + V + ATD DE + + Y T GN F I
Sbjct: 368 RPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIID 427
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG---GRSDTAMVQINITDANNYAPVFENAP 473
GLI AQ LD + + Y L + A+D G +Q+ + D ++ P+F P
Sbjct: 428 PIS-GLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 486
Query: 474 ------YTASVFEDAPIGTTV-LVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
+V E +P GT V V A D+D G NA + Y + A + ++ F +
Sbjct: 487 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI-------AAGNEEKNFHL 539
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARD--------GGVPSL---SDTTDVEISVV--D 573
P G + + LDRE + + V A G P+L +D T E+ VV D
Sbjct: 540 QPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLED 598
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL 620
+ND P F + YTA + DA VG+ + QV A DAD+G N + Y +
Sbjct: 599 INDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 645
Score = 199 bits (485), Expect = 1e-49
Identities = 181/631 (28%), Positives = 291/631 (46%), Gaps = 74/631 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ ++D ND++P+F+ Y+ +V E GT +LT+ ATD D G A +EY++
Sbjct: 150 LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLG------- 202
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV-SDR 129
D + F I+ +G + +SLDREK Y + A D V S+R
Sbjct: 203 ---DG-----------ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 248
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + + ++D ND PQFS+ ++ SV E+ + + + ATD D G N + Y
Sbjct: 249 RENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTS--VITMMATDQDEGPNGELTY 306
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
++ G + F +D SG V+ + L + + L + A DGG P TT LL+ + D
Sbjct: 307 SLEGPGVE-AFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVID 363
Query: 250 VNDNAPRFYTSLFQE--SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
VNDN P F + E +P+ ++ V A D DEG+N + Y+ GN D
Sbjct: 364 VNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT--AGNRDW 421
Query: 308 P-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP-PRSATATXXXXXXXXXXXXXX 365
IDP SG + T+ +LDRE+QA Y L++ A+D G P P
Sbjct: 422 EFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPL 481
Query: 366 FM-----PGQYE-VELAEDEPPGTPVVTLT-ATDADEDNR--LHYEITGGNTRGRFSITS 416
F+ QY+ + + E P GT V +T A DADE ++Y I GN F +
Sbjct: 482 FVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP 541
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSA------TDSGGRSDT---------AMVQINITD 461
G + V + LD ++E + V A T G S T V++ + D
Sbjct: 542 D---GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLED 598
Query: 462 ANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHD 521
N+ P F A YTA V DA +G+ ++ V A D+D+G N+ + YS+ + A+A+
Sbjct: 599 INDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDS 658
Query: 522 ----QQFVINPQTGAITTNKLLDRETMSGYLLTVTARD--G-------GVPSLSDTTDVE 568
Q F + G + T L + +++ + ARD G G+ L D V+
Sbjct: 659 EDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVK 718
Query: 569 ISVVDVNDNEPVFKQQ-LYTANIMEDALVGT 598
I + ++ D F+++ ++ + + A+V T
Sbjct: 719 IVINEIPDRVRGFEEEFIHLLSNITGAIVNT 749
Score = 165 bits (401), Expect = 2e-39
Identities = 124/386 (32%), Positives = 183/386 (47%), Gaps = 34/386 (8%)
Query: 425 VAQPLDFKQERRYVLTVSATDSGG----RS---DTAMVQINITDANNYAPVFEN---APY 474
V P++ + Y +T+S D+ RS A + +N+ D N+ P F+ Y
Sbjct: 2 VKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYY 61
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
+ E A GTT++ V+A D D G+N +TY+L + V D G +
Sbjct: 62 MERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSS------AGKVI 115
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
N+ +D E + TV A D G P + V + +VD+NDN P+F Q Y + ED
Sbjct: 116 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 175
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
VGT + V ATDAD G I Y L E F I+P +G I +LDRE +
Sbjct: 176 PVGTIILTVTATDADSGNFALIEYSLGDG---ESKFAINPTTGDIYVLSSLDREKKDHYI 232
Query: 655 LKAVAIDG----GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
L A+A D + + ++V V I++ D+ND P F + + EN P GT++ +
Sbjct: 233 LTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM 292
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA 770
A D DEGPN + YS++G +F ++ G LVT +S +K+ L + A
Sbjct: 293 ATDQDEGPNGELTYSLEG-PGVEAFHVDMDSG-----LVT-TQRPLQS-YEKFSLTVVAT 344
Query: 771 S---PPLWNDVRVEILVTDVNDNAPV 793
PPLW + + V DVNDN PV
Sbjct: 345 DGGEPPLWGTTMLLVEVIDVNDNRPV 370
Score = 39.5 bits (88), Expect = 0.17
Identities = 21/56 (37%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 9 QQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
Q++ V+ D ND P F +Y A V A G+ ++ + A D DIG N+ V Y+I
Sbjct: 590 QEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 645
>AY563165-1|AAT72165.1| 1114|Homo sapiens cadherin 23 isoform B1
protein.
Length = 1114
Score = 273 bits (669), Expect = 7e-72
Identities = 215/694 (30%), Positives = 334/694 (48%), Gaps = 61/694 (8%)
Query: 100 LTRASLDREKVARYTVLVKATDQASPVSDRLSST--ATIHVNIIDDNDNYPQFSEKTYTV 157
+ ++ ++RE VA Y V + D AS + +R S A + VN++D NDN PQF T
Sbjct: 1 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 60
Query: 158 SVDEDIS-VTDNPVIAKIKATDADVGANSAIRYAIIG----GNTQMQFSIDSLSGDVSLV 212
++ + T + + A D D G N + Y ++ G Q++ DS +G V
Sbjct: 61 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE---DSSAGKVIAN 117
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
+T+DYE+V +RA D GSP R+ + + I D+NDN P F +QE+V E+VP+
Sbjct: 118 RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV 177
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKY 332
G I+ V A DAD G A + Y++ G+ + I+P +G +Y LDRE + Y
Sbjct: 178 GTIILTVTATDADSGNFALIEYSL------GDGESKFAINPTTGDIYVLSSLDREKKDHY 231
Query: 333 QLLVTATDG-GDPP---RSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTL 388
L A D GD R + F Q+ + E+EP GT V+T+
Sbjct: 232 ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITM 291
Query: 389 TATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
ATD DE + L Y + G F + + GL+T +PL + ++ LTV ATD
Sbjct: 292 MATDQDEGPNGELTYSLEGPGVEA-FHVDMDS--GLVTTQRPL--QSYEKFSLTVVATDG 346
Query: 447 GGRS--DTAMVQINITDANNYAPVFENAP--YTASVFEDAPIGTTVLVVSATDSDVGINA 502
G T M+ + + D N+ PVF P + E+ P+ + V V ATD D G+N
Sbjct: 347 GEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNG 406
Query: 503 QITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
+ YS N + F+I+P +G I T + LDRE+ + Y L + A D G P
Sbjct: 407 AVRYSFLKTAGN----RDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY 462
Query: 563 DTTD-VEISVVDVNDNEPVF------KQQLYTANIMEDALVGTSVSQV-GATDADVGLNG 614
+T +++++ D++DNEP+F Q + E + GT V V GA DAD G N
Sbjct: 463 ETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNA 522
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALD--RESVATHDLKAVAIDGGTPPQ--SST 670
++Y + EE +F + P G + + LD RE++ + +KA + TPP+ S T
Sbjct: 523 IVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT 580
Query: 671 V---------IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAV 721
+ V + +EDIND PP F T ++ ++ +G+ + ++ A D D G N++
Sbjct: 581 LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL 640
Query: 722 VHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD 755
V YSI + F D ++ TM +D
Sbjct: 641 VFYSILA---IHYFRALANDSEDVGQVFTMGSMD 671
Score = 232 bits (567), Expect = 2e-59
Identities = 201/647 (31%), Positives = 307/647 (47%), Gaps = 79/647 (12%)
Query: 11 INVLDCNDHSPVFE---MQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI-ELVT 66
+NVLD ND++P F+ + Y + EGA+ GTT++ + A D D G N V YT+ +LV
Sbjct: 41 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP 100
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
+ ED+ +G ++ ++D E+V V+A+D SP
Sbjct: 101 PGYVQLEDSS-------------------AGKVIANRTVDYEEVHWLNFTVRASDNGSPP 141
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
++ +++ I+D NDN P F + +Y +V ED+ V +I + ATDAD G +
Sbjct: 142 R---AAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV--GTIILTVTATDADSGNFAL 196
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDG----GSPSRSNTTQ 242
I Y++ G+ + +F+I+ +GD+ ++ +LD E+ Y L A+D S R N+ Q
Sbjct: 197 IEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQ 254
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
++I + DVND P+F F SV EN P G S++ + A D DEG N ELTY++
Sbjct: 255 VVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE 314
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+D SG V T L ++ K+ L V ATDGG+PP T
Sbjct: 315 A-----FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDN 367
Query: 363 XXXFM--PGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI--TGGNTRGRFSITS 416
F+ P + + E+ P + V + ATD DE + + Y T GN F I
Sbjct: 368 RPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIID 427
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG---GRSDTAMVQINITDANNYAPVFENAP 473
GLI AQ LD + + Y L + A+D G +Q+ + D ++ P+F P
Sbjct: 428 PIS-GLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 486
Query: 474 ------YTASVFEDAPIGTTV-LVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
+V E +P GT V V A D+D G NA + Y + A + ++ F +
Sbjct: 487 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI-------AAGNEEKNFHL 539
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARD--------GGVPSL---SDTTDVEISVV--D 573
P G + + LDRE + + V A G P+L +D T E+ VV D
Sbjct: 540 QPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLED 598
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL 620
+ND P F + YTA + DA VG+ + QV A DAD+G N + Y +
Sbjct: 599 INDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 645
Score = 199 bits (485), Expect = 1e-49
Identities = 181/631 (28%), Positives = 291/631 (46%), Gaps = 74/631 (11%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ ++D ND++P+F+ Y+ +V E GT +LT+ ATD D G A +EY++
Sbjct: 150 LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLG------- 202
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV-SDR 129
D + F I+ +G + +SLDREK Y + A D V S+R
Sbjct: 203 ---DG-----------ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 248
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + + ++D ND PQFS+ ++ SV E+ + + + ATD D G N + Y
Sbjct: 249 RENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTS--VITMMATDQDEGPNGELTY 306
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
++ G + F +D SG V+ + L + + L + A DGG P TT LL+ + D
Sbjct: 307 SLEGPGVE-AFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVID 363
Query: 250 VNDNAPRFYTSLFQE--SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
VNDN P F + E +P+ ++ V A D DEG+N + Y+ GN D
Sbjct: 364 VNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT--AGNRDW 421
Query: 308 P-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP-PRSATATXXXXXXXXXXXXXX 365
IDP SG + T+ +LDRE+QA Y L++ A+D G P P
Sbjct: 422 EFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPL 481
Query: 366 FM-----PGQYE-VELAEDEPPGTPVVTLT-ATDADEDNR--LHYEITGGNTRGRFSITS 416
F+ QY+ + + E P GT V +T A DADE ++Y I GN F +
Sbjct: 482 FVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP 541
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSA------TDSGGRSDT---------AMVQINITD 461
G + V + LD ++E + V A T G S T V++ + D
Sbjct: 542 D---GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLED 598
Query: 462 ANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHD 521
N+ P F A YTA V DA +G+ ++ V A D+D+G N+ + YS+ + A+A+
Sbjct: 599 INDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDS 658
Query: 522 ----QQFVINPQTGAITTNKLLDRETMSGYLLTVTARD--G-------GVPSLSDTTDVE 568
Q F + G + T L + +++ + ARD G G+ L D V+
Sbjct: 659 EDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVK 718
Query: 569 ISVVDVNDNEPVFKQQ-LYTANIMEDALVGT 598
I + ++ D F+++ ++ + + A+V T
Sbjct: 719 IVINEIPDRVRGFEEEFIHLLSNITGAIVNT 749
Score = 165 bits (401), Expect = 2e-39
Identities = 124/386 (32%), Positives = 183/386 (47%), Gaps = 34/386 (8%)
Query: 425 VAQPLDFKQERRYVLTVSATDSGG----RS---DTAMVQINITDANNYAPVFEN---APY 474
V P++ + Y +T+S D+ RS A + +N+ D N+ P F+ Y
Sbjct: 2 VKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYY 61
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
+ E A GTT++ V+A D D G+N +TY+L + V D G +
Sbjct: 62 MERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSS------AGKVI 115
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
N+ +D E + TV A D G P + V + +VD+NDN P+F Q Y + ED
Sbjct: 116 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 175
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHD 654
VGT + V ATDAD G I Y L E F I+P +G I +LDRE +
Sbjct: 176 PVGTIILTVTATDADSGNFALIEYSLGDG---ESKFAINPTTGDIYVLSSLDREKKDHYI 232
Query: 655 LKAVAIDG----GTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
L A+A D + + ++V V I++ D+ND P F + + EN P GT++ +
Sbjct: 233 LTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM 292
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA 770
A D DEGPN + YS++G +F ++ G LVT +S +K+ L + A
Sbjct: 293 ATDQDEGPNGELTYSLEG-PGVEAFHVDMDSG-----LVT-TQRPLQS-YEKFSLTVVAT 344
Query: 771 S---PPLWNDVRVEILVTDVNDNAPV 793
PPLW + + V DVNDN PV
Sbjct: 345 DGGEPPLWGTTMLLVEVIDVNDNRPV 370
Score = 39.5 bits (88), Expect = 0.17
Identities = 21/56 (37%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 9 QQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
Q++ V+ D ND P F +Y A V A G+ ++ + A D DIG N+ V Y+I
Sbjct: 590 QEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 645
>AY029205-1|AAK31581.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 273 bits (669), Expect = 7e-72
Identities = 255/836 (30%), Positives = 387/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D+ P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDSGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IAK--IKATDADVGANS-----AIRYAIIGGNTQMQ---FSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT + T R ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITR--YLTLLLPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDGVQ--ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG 448
DADE + + YEI G +G F I G LIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTG--LITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 449 ----RSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-- 757
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 758 -NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKQIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 204 bits (499), Expect = 3e-51
Identities = 208/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D+ P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDSGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ P+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLLPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A DG P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNREV-RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVGP-FGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTVL-VEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPP 924
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 925 V--FSKQIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRVN--LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEE 1039
Query: 474 YTAS-VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 188 bits (459), Expect = 2e-46
Identities = 176/587 (29%), Positives = 269/587 (45%), Gaps = 57/587 (9%)
Query: 11 INVLDCNDHSPVFE--MQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTAD 68
I V D ND++PVF+ + + + V E A++ V +KATD D G N +V Y++
Sbjct: 705 IVVTDVNDNAPVFDPYLPRNLSVVEEEANA--FVGQVKATDPDAGINGQVHYSL------ 756
Query: 69 TLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
++FRI +G++ T L+RE Y ++V ATD A V
Sbjct: 757 ---------------GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGA--VHP 798
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
R ST T+ + ++D +DN P F+ TYTV V+E++ I +I+A D D+GAN +
Sbjct: 799 R-HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA--GTTILQIEAKDVDLGAN--VS 853
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYE----QVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y I + F++ +G++SL+++LDYE Q S ++ A D +
Sbjct: 854 YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT 913
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADE-GVNAE-LTYTMTDKDYT 302
+ ++D+ND P F +++ V+ + G I V A DAD G+ A + Y + D +
Sbjct: 914 VIVKDMNDYPPVFSKQIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 973
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++ SG V T L+ E ++L+V A D G+P S++AT
Sbjct: 974 YPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI 1032
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
++E GT V ++A ++ + Y I GN F I N G+
Sbjct: 1033 PRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--IVYSIVSGNEEDTFGIN--NITGV 1088
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG---------GRSDTAMVQINITDANNYAPVFENAP 473
I V PLD++ YVL V A +S+TA V I I D NN+ PVF+
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 474 YTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAI 533
Y V EDA + T+VL V ATD D G + + Y L E + FV+ TG I
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG----KEGFVVETYTGLI 1204
Query: 534 TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
T L S + V A D LS DV +SVV+ D + +
Sbjct: 1205 KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1251
Score = 159 bits (387), Expect = 1e-37
Identities = 183/695 (26%), Positives = 294/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRV-----QAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDSGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGRGL-ITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL---DRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG LL DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLLPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDREST-DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 50.0 bits (114), Expect = 1e-04
Identities = 56/217 (25%), Positives = 96/217 (44%), Gaps = 21/217 (9%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR-----V 780
DD S +V L+YE + +Y ++I+A N+ R +
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 781 EILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVP 817
+ V D +D+ P+ ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDSGPMFLPC-VLVPNTRDCRPLTYQAAIP 287
>AF152523-1|AAD43783.1| 808|Homo sapiens protocadherin gamma B7
short form protein protein.
Length = 808
Score = 273 bits (669), Expect = 7e-72
Identities = 179/605 (29%), Positives = 287/605 (47%), Gaps = 25/605 (4%)
Query: 197 QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAP 255
++ FS+D+ SGD+ + +D EQ+ R Q + + N +++ I DVND+AP
Sbjct: 72 KLHFSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAP 131
Query: 256 RFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRS 315
+F +SE+V +G + A D D +N+ Y ++ +Y V+ +
Sbjct: 132 QFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKY 191
Query: 316 GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVEL 375
+ LDRETQ+ + L++TA DGGDPPRS TA F Y V L
Sbjct: 192 PELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSL 251
Query: 376 AEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQ 433
ED PPGT ++ + ATD DE ++ + Y G + + + G I QPLDF++
Sbjct: 252 REDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEE 311
Query: 434 ERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSA 493
RY + + A D G S V + + D N+ +P + + ED+P G V +
Sbjct: 312 VERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKT 371
Query: 494 TDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D D G N ++ SLS + + + + + + T++ LDRE Y +T+ A
Sbjct: 372 RDQDSGENGEVRCSLSRGVPFKIHSSSNNYY-------KLVTDEALDREQTPEYNVTIAA 424
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D G P LS + + + + DVNDN PVF Q Y ++ E+ G S++QV A+D D GLN
Sbjct: 425 TDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLN 484
Query: 614 GRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GR+ Y L D + R S+V + SGV+ +A D E + T +L A D G+P S+
Sbjct: 485 GRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSA 544
Query: 670 TVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
V + + + D ND+ P + L + + G + ++ A D D G NA +
Sbjct: 545 NVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWL 604
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWNDVRVE 781
Y + + FSL R G + +V + D +S R++ + +R PPL +
Sbjct: 605 SYHVVQASEPGLFSLGLRTG--EVRMVRALG-DKDSVRQRLLVAVRDGGQPPLSATATLH 661
Query: 782 ILVTD 786
++ D
Sbjct: 662 LVFAD 666
Score = 245 bits (599), Expect = 2e-63
Identities = 188/610 (30%), Positives = 299/610 (49%), Gaps = 38/610 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F +D +SG LL + +DRE++ + + Q V + + + V I D ND+ PQ
Sbjct: 75 FSVDAQSGDLLVKDRIDREQICKERRRCEL--QLEAVVENPLNIFHVIVVIEDVNDHAPQ 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F + + + E +S+ ++ A D D+ NS +Y + D+ G
Sbjct: 133 FRKDEINLEISESVSLGMGTILES--AEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L KTLD E ++ LV+ A DGG P RS T Q+ I + D NDN P F +++ S
Sbjct: 191 YPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E+VP G SI+RV+A D DEG+N+E+TY+ ++D +G + T LD
Sbjct: 251 LREDVPPGTSILRVKATDQDEGINSEITYSFF--GVADKAQHVFSLDYTTGNILTQQPLD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y + + A D G S + ++ ED PPG V
Sbjct: 309 FEEVERYTINIEAKDRGS--LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGV-V 365
Query: 386 VTLTATDADEDNRLHYEITGGNTRG-RFSI-TSQNGRGLITVAQPLDFKQERRYVLTVSA 443
V L T D+D+ + E+ +RG F I +S N + + LD +Q Y +T++A
Sbjct: 366 VALFKT-RDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAA 424
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G S + + ++ITD N+ APVF + Y V E+ G ++ VSA+D D G+N
Sbjct: 425 TDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLN 484
Query: 502 AQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
+++YSL +S++ + ++ + ++ Q+G + + D E + + LT+ ARD G P+
Sbjct: 485 GRVSYSLIASDLESRTLSSY---VSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPA 541
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDADV 610
LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 542 LSANVSLRVLVGDRNDNAP---RVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADS 598
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKAL-DRESVATHDLKAVAIDGGTPPQSS 669
G N + Y + + E G F + +G +R +AL D++SV L AV DGG PP S+
Sbjct: 599 GHNAWLSYHV-VQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVR-DGGQPPLSA 656
Query: 670 TVIVHIKIED 679
T +H+ D
Sbjct: 657 TATLHLVFAD 666
Score = 196 bits (478), Expect = 9e-49
Identities = 167/588 (28%), Positives = 268/588 (45%), Gaps = 61/588 (10%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F + + E S G + A D DI N+ +Y
Sbjct: 118 HVIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + V+ G+ L+ + +LDRE + + +++ A D P
Sbjct: 171 -QLSPNE-------YFSLVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPPR 222
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
S TA I + +ID NDN P FS+ Y VS+ ED V I ++KATD D G NS I
Sbjct: 223 ---SGTAQIRILVIDANDNPPVFSQDVYRVSLRED--VPPGTSILRVKATDQDEGINSEI 277
Query: 188 RYAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y+ G Q FS+D +G++ + LD+E+V Y + I A+D G S S ++++
Sbjct: 278 TYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEVERYTINIEAKDRG--SLSTRCKVIV 335
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
+ D NDN+P + + + E+ P G + + D D G N E+ +++
Sbjct: 336 EVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSR------- 388
Query: 306 DLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+P I S Y T LDRE +Y + + ATD G PP S++ T
Sbjct: 389 GVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDN 448
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR-----FSIT 415
F Y V + E+ PG + ++A+D D + R+ Y + + R S++
Sbjct: 449 APVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVS 508
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA 472
+Q+ G++ + D +Q R + LT+ A D G + +A V + + D N+ AP V A
Sbjct: 509 AQS--GVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPA 566
Query: 473 --PYTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
P +++F+ P G V V A D+D G NA ++Y + A F +
Sbjct: 567 LGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHV-------VQASEPGLFSL 619
Query: 527 NPQTGAITTNKLL-DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+TG + + L D++++ LL V RDGG P LS T + + D
Sbjct: 620 GLRTGEVRMVRALGDKDSVRQRLL-VAVRDGGQPPLSATATLHLVFAD 666
Score = 192 bits (469), Expect = 1e-47
Identities = 149/468 (31%), Positives = 223/468 (47%), Gaps = 30/468 (6%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD + + + L ++A D G RS TA ++I + DAN+ PVF Y S+ E
Sbjct: 194 LVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLRE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
D P GT++L V ATD D GIN++ITYS ++++A F ++ TG I T + LD
Sbjct: 254 DVPPGTSILRVKATDQDEGINSEITYSFFG-VADKA----QHVFSLDYTTGNILTQQPLD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A+D G SLS V + VVD NDN P + IMED+ G V
Sbjct: 309 FEEVERYTINIEAKDRG--SLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVV 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ D D G NG + L F I +S + T++ALDRE +++
Sbjct: 367 ALFKTRDQDSGENGEVRCSLS----RGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTI 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D G PP SS+ + + I D+ND+ PVF ++ EN+ G +I ++ A DPD G
Sbjct: 423 AATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFG 482
Query: 718 PNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N V YS+ D +S + S + + D+E R +EL ++A SP
Sbjct: 483 LNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLR-TFELTLQARDQGSPA 541
Query: 774 LWNDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
L +V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 542 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHN 601
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y ++ + L L TG + + L + V+V DG
Sbjct: 602 AWLSYHVVQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVRDG 649
Score = 176 bits (429), Expect = 8e-43
Identities = 144/472 (30%), Positives = 221/472 (46%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V+D ND+ PVF Y S+RE GT++L +KATDQD G N+E+ Y+ V AD
Sbjct: 229 RILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGV-ADK 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
Q VF +D +G +LT+ LD E+V RYT+ ++A D+ S
Sbjct: 288 ----------------AQHVFSLDYTTGNILTQQPLDFEEVERYTINIEAKDRGS----- 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
LS+ + V ++D+NDN P+ + + + ED V+A K D D G N +R
Sbjct: 327 LSTRCKVIVEVVDENDNSPEIIITSLSDQIMED--SPPGVVVALFKTRDQDSGENGEVRC 384
Query: 190 AIIGGNTQMQFSIDSLSGD-VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++ G + F I S S + LV + LD EQ Y + I A D G P S++ + ++
Sbjct: 385 SLSRG---VPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDRGKPPLSSSKTITLH 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY-TGNV 305
I DVNDNAP F S + V EN G SI +V A D D G+N ++Y++ D + +
Sbjct: 442 ITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ +SG V+ D E ++L + A D G P SA +
Sbjct: 502 SSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPR 561
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 562 VLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGLFSLGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + + + L K R L V+ D G +A +++ A++ V
Sbjct: 622 RTGE--VRMVRALGDKDSVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 671
Score = 119 bits (287), Expect = 1e-25
Identities = 84/276 (30%), Positives = 132/276 (47%), Gaps = 12/276 (4%)
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFK 582
F ++ Q+G + +DRE + + + V + + V + + DVND+ P F+
Sbjct: 75 FSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFR 134
Query: 583 QQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV---I 639
+ I E +G A D D+ +N Y+L P + +P G +
Sbjct: 135 KDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPEL 194
Query: 640 RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
K LDRE+ + H L A+DGG PP+S T + I + D ND+PPVF D + E+
Sbjct: 195 VLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLRED 254
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDLDYE 757
P GT+I ++A D DEG N+ + YS G D + FSL+ G+ ++T LD+E
Sbjct: 255 VPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGN----ILTQQPLDFE 310
Query: 758 SPRKKYELVIRAAS-PPLWNDVRVEILVTDVNDNAP 792
++Y + I A L +V + V D NDN+P
Sbjct: 311 EV-ERYTINIEAKDRGSLSTRCKVIVEVVDENDNSP 345
>AF152336-1|AAD43730.1| 929|Homo sapiens protocadherin gamma B7
protein.
Length = 929
Score = 273 bits (669), Expect = 7e-72
Identities = 179/605 (29%), Positives = 287/605 (47%), Gaps = 25/605 (4%)
Query: 197 QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAP 255
++ FS+D+ SGD+ + +D EQ+ R Q + + N +++ I DVND+AP
Sbjct: 72 KLHFSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAP 131
Query: 256 RFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRS 315
+F +SE+V +G + A D D +N+ Y ++ +Y V+ +
Sbjct: 132 QFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKY 191
Query: 316 GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVEL 375
+ LDRETQ+ + L++TA DGGDPPRS TA F Y V L
Sbjct: 192 PELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSL 251
Query: 376 AEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQ 433
ED PPGT ++ + ATD DE ++ + Y G + + + G I QPLDF++
Sbjct: 252 REDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEE 311
Query: 434 ERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSA 493
RY + + A D G S V + + D N+ +P + + ED+P G V +
Sbjct: 312 VERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKT 371
Query: 494 TDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D D G N ++ SLS + + + + + + T++ LDRE Y +T+ A
Sbjct: 372 RDQDSGENGEVRCSLSRGVPFKIHSSSNNYY-------KLVTDEALDREQTPEYNVTIAA 424
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D G P LS + + + + DVNDN PVF Q Y ++ E+ G S++QV A+D D GLN
Sbjct: 425 TDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLN 484
Query: 614 GRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GR+ Y L D + R S+V + SGV+ +A D E + T +L A D G+P S+
Sbjct: 485 GRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSA 544
Query: 670 TVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
V + + + D ND+ P + L + + G + ++ A D D G NA +
Sbjct: 545 NVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWL 604
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWNDVRVE 781
Y + + FSL R G + +V + D +S R++ + +R PPL +
Sbjct: 605 SYHVVQASEPGLFSLGLRTG--EVRMVRALG-DKDSVRQRLLVAVRDGGQPPLSATATLH 661
Query: 782 ILVTD 786
++ D
Sbjct: 662 LVFAD 666
Score = 245 bits (599), Expect = 2e-63
Identities = 188/610 (30%), Positives = 299/610 (49%), Gaps = 38/610 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F +D +SG LL + +DRE++ + + Q V + + + V I D ND+ PQ
Sbjct: 75 FSVDAQSGDLLVKDRIDREQICKERRRCEL--QLEAVVENPLNIFHVIVVIEDVNDHAPQ 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F + + + E +S+ ++ A D D+ NS +Y + D+ G
Sbjct: 133 FRKDEINLEISESVSLGMGTILES--AEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L KTLD E ++ LV+ A DGG P RS T Q+ I + D NDN P F +++ S
Sbjct: 191 YPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ E+VP G SI+RV+A D DEG+N+E+TY+ ++D +G + T LD
Sbjct: 251 LREDVPPGTSILRVKATDQDEGINSEITYSFF--GVADKAQHVFSLDYTTGNILTQQPLD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y + + A D G S + ++ ED PPG V
Sbjct: 309 FEEVERYTINIEAKDRGS--LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGV-V 365
Query: 386 VTLTATDADEDNRLHYEITGGNTRG-RFSI-TSQNGRGLITVAQPLDFKQERRYVLTVSA 443
V L T D+D+ + E+ +RG F I +S N + + LD +Q Y +T++A
Sbjct: 366 VALFKT-RDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAA 424
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G S + + ++ITD N+ APVF + Y V E+ G ++ VSA+D D G+N
Sbjct: 425 TDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLN 484
Query: 502 AQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
+++YSL +S++ + ++ + ++ Q+G + + D E + + LT+ ARD G P+
Sbjct: 485 GRVSYSLIASDLESRTLSSY---VSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPA 541
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDADV 610
LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 542 LSANVSLRVLVGDRNDNAP---RVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADS 598
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKAL-DRESVATHDLKAVAIDGGTPPQSS 669
G N + Y + + E G F + +G +R +AL D++SV L AV DGG PP S+
Sbjct: 599 GHNAWLSYHV-VQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVR-DGGQPPLSA 656
Query: 670 TVIVHIKIED 679
T +H+ D
Sbjct: 657 TATLHLVFAD 666
Score = 196 bits (478), Expect = 9e-49
Identities = 167/588 (28%), Positives = 268/588 (45%), Gaps = 61/588 (10%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F + + E S G + A D DI N+ +Y
Sbjct: 118 HVIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + V+ G+ L+ + +LDRE + + +++ A D P
Sbjct: 171 -QLSPNE-------YFSLVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPPR 222
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
S TA I + +ID NDN P FS+ Y VS+ ED V I ++KATD D G NS I
Sbjct: 223 ---SGTAQIRILVIDANDNPPVFSQDVYRVSLRED--VPPGTSILRVKATDQDEGINSEI 277
Query: 188 RYAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y+ G Q FS+D +G++ + LD+E+V Y + I A+D G S S ++++
Sbjct: 278 TYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEVERYTINIEAKDRG--SLSTRCKVIV 335
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
+ D NDN+P + + + E+ P G + + D D G N E+ +++
Sbjct: 336 EVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSR------- 388
Query: 306 DLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+P I S Y T LDRE +Y + + ATD G PP S++ T
Sbjct: 389 GVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDN 448
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR-----FSIT 415
F Y V + E+ PG + ++A+D D + R+ Y + + R S++
Sbjct: 449 APVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVS 508
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA 472
+Q+ G++ + D +Q R + LT+ A D G + +A V + + D N+ AP V A
Sbjct: 509 AQS--GVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPA 566
Query: 473 --PYTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
P +++F+ P G V V A D+D G NA ++Y + A F +
Sbjct: 567 LGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHV-------VQASEPGLFSL 619
Query: 527 NPQTGAITTNKLL-DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+TG + + L D++++ LL V RDGG P LS T + + D
Sbjct: 620 GLRTGEVRMVRALGDKDSVRQRLL-VAVRDGGQPPLSATATLHLVFAD 666
Score = 192 bits (469), Expect = 1e-47
Identities = 149/468 (31%), Positives = 223/468 (47%), Gaps = 30/468 (6%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD + + + L ++A D G RS TA ++I + DAN+ PVF Y S+ E
Sbjct: 194 LVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLRE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
D P GT++L V ATD D GIN++ITYS ++++A F ++ TG I T + LD
Sbjct: 254 DVPPGTSILRVKATDQDEGINSEITYSFFG-VADKA----QHVFSLDYTTGNILTQQPLD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A+D G SLS V + VVD NDN P + IMED+ G V
Sbjct: 309 FEEVERYTINIEAKDRG--SLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVV 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ D D G NG + L F I +S + T++ALDRE +++
Sbjct: 367 ALFKTRDQDSGENGEVRCSLS----RGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTI 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D G PP SS+ + + I D+ND+ PVF ++ EN+ G +I ++ A DPD G
Sbjct: 423 AATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFG 482
Query: 718 PNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N V YS+ D +S + S + + D+E R +EL ++A SP
Sbjct: 483 LNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLR-TFELTLQARDQGSPA 541
Query: 774 LWNDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
L +V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 542 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHN 601
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y ++ + L L TG + + L + V+V DG
Sbjct: 602 AWLSYHVVQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVRDG 649
Score = 176 bits (429), Expect = 8e-43
Identities = 144/472 (30%), Positives = 221/472 (46%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V+D ND+ PVF Y S+RE GT++L +KATDQD G N+E+ Y+ V AD
Sbjct: 229 RILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGV-ADK 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
Q VF +D +G +LT+ LD E+V RYT+ ++A D+ S
Sbjct: 288 ----------------AQHVFSLDYTTGNILTQQPLDFEEVERYTINIEAKDRGS----- 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
LS+ + V ++D+NDN P+ + + + ED V+A K D D G N +R
Sbjct: 327 LSTRCKVIVEVVDENDNSPEIIITSLSDQIMED--SPPGVVVALFKTRDQDSGENGEVRC 384
Query: 190 AIIGGNTQMQFSIDSLSGD-VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++ G + F I S S + LV + LD EQ Y + I A D G P S++ + ++
Sbjct: 385 SLSRG---VPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDRGKPPLSSSKTITLH 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY-TGNV 305
I DVNDNAP F S + V EN G SI +V A D D G+N ++Y++ D + +
Sbjct: 442 ITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ +SG V+ D E ++L + A D G P SA +
Sbjct: 502 SSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPR 561
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 562 VLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGLFSLGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + + + L K R L V+ D G +A +++ A++ V
Sbjct: 622 RTGE--VRMVRALGDKDSVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 671
Score = 119 bits (287), Expect = 1e-25
Identities = 84/276 (30%), Positives = 132/276 (47%), Gaps = 12/276 (4%)
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFK 582
F ++ Q+G + +DRE + + + V + + V + + DVND+ P F+
Sbjct: 75 FSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFR 134
Query: 583 QQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV---I 639
+ I E +G A D D+ +N Y+L P + +P G +
Sbjct: 135 KDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPEL 194
Query: 640 RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
K LDRE+ + H L A+DGG PP+S T + I + D ND+PPVF D + E+
Sbjct: 195 VLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLRED 254
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDLDYE 757
P GT+I ++A D DEG N+ + YS G D + FSL+ G+ ++T LD+E
Sbjct: 255 VPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGN----ILTQQPLDFE 310
Query: 758 SPRKKYELVIRAAS-PPLWNDVRVEILVTDVNDNAP 792
++Y + I A L +V + V D NDN+P
Sbjct: 311 EV-ERYTINIEAKDRGSLSTRCKVIVEVVDENDNSP 345
>AY029237-1|AAK31804.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL365496-10|CAM19874.1| 1957|Homo sapiens protocadherin 15 protein.
Length = 1957
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL365496-9|CAH73916.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL365496-8|CAM19873.1| 1952|Homo sapiens protocadherin 15 protein.
Length = 1952
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL365496-7|CAM19872.1| 1932|Homo sapiens protocadherin 15 protein.
Length = 1932
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 112 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 171
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 172 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 216
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 217 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 276
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 277 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 336
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 337 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 395
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 396 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 453
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 454 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 511
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 512 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 568
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 569 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 625
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 626 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 677
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 678 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 734
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 735 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 793
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 794 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 850
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 851 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 903
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 475 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 530
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 531 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 573
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 574 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 628
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 629 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 687
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 688 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 740
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 741 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 799
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 800 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 857
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 858 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 917
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 918 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 974
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 975 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1033
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1034 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1088
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1089 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1148
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1149 KDTGNYSVMAYRL 1161
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 371
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 372 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 431
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 432 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 489
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 490 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 544
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 545 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 604
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 605 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 661
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 662 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 718
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 719 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 768
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 829 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 885
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 886 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 943
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 944 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1001
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1002 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1058
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1059 GINNITGVIYVNGPLD 1074
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 168
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 169 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 344
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 345 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 404
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 405 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 462
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 463 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 523 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 574
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 575 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 631
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 632 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 689
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 690 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 746
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 747 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 801
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 802 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 631
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 632 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 675
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 676 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 731
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 732 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 788
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 789 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 842
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 843 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 900
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 961 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1017
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1018 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1066
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1067 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1126
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1127 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1184
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 170 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 409 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 464
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 465 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 525 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 639
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 640 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 694
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 695 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 753
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 754 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 788
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 52 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 110
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 265
>AL365496-4|CAM19869.1| 1539|Homo sapiens protocadherin 15 protein.
Length = 1539
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL360214-13|CAM21544.1| 1932|Homo sapiens protocadherin 15 protein.
Length = 1932
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 112 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 171
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 172 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 216
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 217 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 276
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 277 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 336
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 337 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 395
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 396 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 453
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 454 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 511
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 512 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 568
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 569 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 625
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 626 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 677
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 678 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 734
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 735 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 793
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 794 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 850
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 851 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 903
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 475 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 530
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 531 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 573
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 574 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 628
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 629 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 687
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 688 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 740
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 741 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 799
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 800 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 857
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 858 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 917
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 918 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 974
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 975 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1033
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1034 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1088
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1089 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1148
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1149 KDTGNYSVMAYRL 1161
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 371
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 372 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 431
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 432 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 489
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 490 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 544
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 545 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 604
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 605 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 661
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 662 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 718
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 719 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 768
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 829 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 885
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 886 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 943
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 944 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1001
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1002 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1058
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1059 GINNITGVIYVNGPLD 1074
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 168
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 169 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 344
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 345 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 404
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 405 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 462
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 463 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 523 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 574
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 575 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 631
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 632 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 689
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 690 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 746
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 747 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 801
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 802 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 631
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 632 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 675
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 676 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 731
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 732 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 788
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 789 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 842
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 843 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 900
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 961 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1017
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1018 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1066
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1067 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1126
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1127 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1184
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 170 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 409 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 464
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 465 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 525 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 639
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 640 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 694
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 695 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 753
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 754 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 788
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 52 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 110
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 265
>AL360214-12|CAM21543.1| 1952|Homo sapiens protocadherin 15 protein.
Length = 1952
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL360214-11|CAM21542.1| 1957|Homo sapiens protocadherin 15 protein.
Length = 1957
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL360214-10|CAI15201.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL360214-5|CAM21537.1| 1539|Homo sapiens protocadherin 15 protein.
Length = 1539
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL360214-3|CAI15200.1| 961|Homo sapiens protocadherin 15 protein.
Length = 961
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 206 bits (502), Expect = 1e-51
Identities = 209/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 204 bits (498), Expect = 4e-51
Identities = 182/649 (28%), Positives = 303/649 (46%), Gaps = 55/649 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+TV V +K D+ND PPVF ++ ++ GT I + A D D
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Score = 192 bits (467), Expect = 2e-47
Identities = 178/623 (28%), Positives = 287/623 (46%), Gaps = 63/623 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-------- 434
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
DT +PE VF + G + L +DRE+ YT + A D
Sbjct: 435 DTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 490 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 542
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 543 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
Query: 244 LINIRDVNDNAP-RFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ +P RF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 654
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+DG P ++TAT
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTDVNDN 713
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGR 420
F P +E V + ATD D + ++HY + GN F ITS
Sbjct: 714 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN--- 768
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 879
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P T V + V D+ND PVF +++Y +
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAP 937
Query: 593 DALVGTSVSQVGATDADVGLNGR 615
DA+ GT ++ V A DAD ++ R
Sbjct: 938 DAVKGTPITTVYAEDADPPVSRR 960
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL356114-13|CAH71769.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL356114-12|CAM15125.1| 1932|Homo sapiens protocadherin 15 protein.
Length = 1932
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 112 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 171
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 172 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 216
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 217 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 276
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 277 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 336
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 337 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 395
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 396 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 453
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 454 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 511
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 512 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 568
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 569 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 625
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 626 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 677
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 678 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 734
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 735 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 793
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 794 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 850
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 851 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 903
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 475 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 530
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 531 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 573
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 574 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 628
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 629 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 687
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 688 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 740
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 741 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 799
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 800 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 857
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 858 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 917
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 918 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 974
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 975 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1033
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1034 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1088
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1089 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1148
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1149 KDTGNYSVMAYRL 1161
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 371
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 372 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 431
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 432 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 489
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 490 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 544
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 545 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 604
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 605 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 661
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 662 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 718
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 719 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 768
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 769 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 829 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 885
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 886 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 943
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 944 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1001
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1002 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1058
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1059 GINNITGVIYVNGPLD 1074
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 168
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 169 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 344
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 345 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 404
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 405 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 462
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 463 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 522
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 523 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 574
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 575 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 631
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 632 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 689
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 690 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 746
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 747 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 801
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 802 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 859
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 581 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 631
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 632 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 675
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 676 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 731
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 732 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 788
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 789 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 842
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 843 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 900
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 961 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1017
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1018 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1066
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1067 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1126
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1127 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1184
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 170 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 228
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 229 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 288
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 289 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 348
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 349 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 408
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 409 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 464
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 465 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 524
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 525 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 582
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 583 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 639
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 640 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 694
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 695 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 753
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 754 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 788
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 52 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 110
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 229
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 230 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 265
>AL356114-11|CAM15124.1| 1957|Homo sapiens protocadherin 15 protein.
Length = 1957
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL356114-10|CAM15123.1| 1952|Homo sapiens protocadherin 15 protein.
Length = 1952
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL356114-7|CAM15120.1| 1539|Homo sapiens protocadherin 15 protein.
Length = 1539
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL356114-3|CAH71768.1| 961|Homo sapiens protocadherin 15 protein.
Length = 961
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 206 bits (502), Expect = 1e-51
Identities = 209/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 204 bits (498), Expect = 4e-51
Identities = 182/649 (28%), Positives = 303/649 (46%), Gaps = 55/649 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+TV V +K D+ND PPVF ++ ++ GT I + A D D
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Score = 192 bits (467), Expect = 2e-47
Identities = 178/623 (28%), Positives = 287/623 (46%), Gaps = 63/623 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-------- 434
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
DT +PE VF + G + L +DRE+ YT + A D
Sbjct: 435 DTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 490 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 542
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 543 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
Query: 244 LINIRDVNDNAP-RFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ +P RF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 654
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+DG P ++TAT
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTDVNDN 713
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGR 420
F P +E V + ATD D + ++HY + GN F ITS
Sbjct: 714 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN--- 768
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 879
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P T V + V D+ND PVF +++Y +
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAP 937
Query: 593 DALVGTSVSQVGATDADVGLNGR 615
DA+ GT ++ V A DAD ++ R
Sbjct: 938 DAVKGTPITTVYAEDADPPVSRR 960
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL353784-11|CAM16792.1| 1957|Homo sapiens protocadherin 15 protein.
Length = 1957
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL353784-10|CAH72390.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL353784-9|CAM16791.1| 1952|Homo sapiens protocadherin 15 protein.
Length = 1952
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL353784-5|CAM16787.1| 1539|Homo sapiens protocadherin 15 protein.
Length = 1539
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 244 bits (598), Expect = 3e-63
Identities = 212/733 (28%), Positives = 343/733 (46%), Gaps = 63/733 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND++P F Y+ V G +V+ L A D D G N E+ Y I LV A
Sbjct: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-LVGA--- 552
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
Q F I+ +G + ++ Y + V+A D A P ++R
Sbjct: 553 ----------------QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP-AERR 595
Query: 131 SSTATIHVNIID-DNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
+S T+++ ++ +N + P+F + Y++ + E + V V+ ++ATD + +I Y
Sbjct: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITY 650
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
AI G+ Q F++ +G ++L K LD E Y L+I A DG P ++T + I + D
Sbjct: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG-RPDGTSTATVNIVVTD 709
Query: 250 VNDNAPRFYTSLFQE-SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
VNDNAP F L + SV E + + +V+A D D G+N ++ Y++ GN +
Sbjct: 710 VNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSL------GNFNNL 762
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
I +G +YT+ +L+RE + Y+L+V ATDG PR +T T F
Sbjct: 763 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 821
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
Y V + E+ P GT ++ + A D D + Y I + F++ G +++ +
Sbjct: 822 STYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRS 879
Query: 429 LDFK----QERRYVLTVSATDSGGRSDT--AMVQINITDANNYAPVFENAPYTASVFEDA 482
LD++ QE V A D G A V + + D N+Y PVF Y V DA
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
Query: 483 PIGTTVLVVSATDSDV-GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
GT + V A D+D G+ A + + + + F + +G + T L+
Sbjct: 940 VKGTPITTVYAEDADPPGLPAS---RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-IMEDALVGTSV 600
E + + L V A D G P +S + V+I V+ + P F Q+ Y + E A GT V
Sbjct: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMV 1055
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES-------VATH 653
+ A +N I Y + EE +F I+ +GVI N LD E+ V
Sbjct: 1056 GVISAA----AINQSIVYSI-VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQAD 1110
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
L+ V + P +S+T V+I+I+D N+ PPVF+ +SE++ + T++ ++A D
Sbjct: 1111 SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1170
Query: 714 PDEGPNAVVHYSI 726
D G +V+ Y +
Sbjct: 1171 KDTGNYSVMAYRL 1183
Score = 214 bits (523), Expect = 3e-54
Identities = 214/796 (26%), Positives = 362/796 (45%), Gaps = 66/796 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG--PNAVVHY 724
+TV V +K D+ND PPVF ++ ++ GT I + A D D P + V Y
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 965
Query: 725 SIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVE 781
+ S+ + D ++T V+L+ E P ++LV+ A P + + V+
Sbjct: 966 RVDDVQFPYPASIFEVE-EDSGRVITRVNLN-EEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Query: 782 ILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDKLQYRILSGNNANLI 840
ILV + P + + G G + A A + + Y I+SGN +
Sbjct: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTF 1080
Query: 841 LLNETTGSMTLSPQLN 856
+N TG + ++ L+
Sbjct: 1081 GINNITGVIYVNGPLD 1096
Score = 206 bits (502), Expect = 1e-51
Identities = 210/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG---------TPVVTL 388
A P A A F Y+ + E P G T + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 653
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 654 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 697
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 698 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 753
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 754 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 811 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 864
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 865 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 922
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 923 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 983 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1088
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1089 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1148
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1149 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL353784-2|CAH72389.1| 961|Homo sapiens protocadherin 15 protein.
Length = 961
Score = 272 bits (667), Expect = 1e-71
Identities = 254/836 (30%), Positives = 386/836 (46%), Gaps = 96/836 (11%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQA 330
+R+ A D D + + DYT +T + ++ +DRE Q
Sbjct: 418 LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQPVDREEQQ 475
Query: 331 KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTA 390
Y +TA DG S F Y+V + D PG V+ LTA
Sbjct: 476 TYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 391 TDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
DADE + + YEI G +G F I GLIT+A ++ R Y LTV A D+
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTVQAADNAP 590
Query: 448 ---GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
R+ V I + NN +P F Y+ + E +G +L + ATD +
Sbjct: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG P +
Sbjct: 648 ITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTS 699
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
T V I V DVNDN PVF L + + V QV ATD D G+NG++HY L
Sbjct: 700 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
F I ++G I T L+RE ++L VA DG P+ ST+ + IK+ DI+D+
Sbjct: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 815
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+L G
Sbjct: 816 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG- 872
Query: 744 DKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDNAPV 793
EL + LDYE+ P ++ + + ++ + V ++V D+ND PV
Sbjct: 873 ---ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Score = 206 bits (502), Expect = 1e-51
Identities = 209/779 (26%), Positives = 340/779 (43%), Gaps = 88/779 (11%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD----EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
A D D +D LH + + F++T +T+ QP+D ++++ Y +++A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
Query: 445 DSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D G N +I
Sbjct: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS--LS 562
TY E + F+IN TG IT ++ Y LTV A D P+ +
Sbjct: 545 TY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 563 DTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD 621
V I V+ N+ P F Q +Y+ I E VG + + ATD + I Y ++
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 622 PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDIN 681
D + F + +G++ KALDRES + L A D G P +ST V+I + D+N
Sbjct: 654 NGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
Query: 682 DSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
D+ PVF+ +G+++A DPD G N VHYS+ G+ +N F + T
Sbjct: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSN 768
Query: 742 GSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQ 798
GS + T V L+ E R YELV+ A A P + + + I V D++DN+PV +
Sbjct: 769 GS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
Query: 799 IIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P G ++ A D D+ + YRI S + L+ TG ++L L+
Sbjct: 824 YTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Score = 204 bits (498), Expect = 4e-51
Identities = 182/649 (28%), Positives = 303/649 (46%), Gaps = 55/649 (8%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKAT-DQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + R+ L ++R+ ++ +++KA D P L + A +H+ I+D+N+ P
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP----LPAFAGLHIEILDENNQSP 393
Query: 149 QFSEKTYTVSVDEDI----SVTDNPVIA---KIKATDADVGANSAIRYAIIGGNTQMQFS 201
F+ +Y + E +++D+ + +I A D D+ + + F+
Sbjct: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
Query: 202 IDS--LSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
+ ++ ++L++ +D E+ ++Y I A DG S + I + D NDN P F
Sbjct: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE 511
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ V ++ G S++++ A DADEG N E+TY + I+ +G +
Sbjct: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY-----EILVGAQGDFIINKTTGLIT 566
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPP--RSATATXXXXXXXXXXXXXXFMPG-QYEVELA 376
+ ++ Y L V A D P R++ T P Y +E++
Sbjct: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
Query: 377 EDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
E G ++ L ATD + D+ + Y I G+ + F+++ G++T+ + LD + R
Sbjct: 627 EAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT--GILTLGKALDRESTDR 683
Query: 437 YVLTVSATDSGGRSD---TAMVQINITDANNYAPVFE-NAPYTASVFEDAPIGTTVLVVS 492
Y+L ++A+D GR D TA V I +TD N+ APVF+ P SV E+ V V
Sbjct: 684 YILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 740
Query: 493 ATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVT 552
ATD D GIN Q+ YSL + + F I G+I T L+RE Y L V
Sbjct: 741 ATDPDAGINGQVHYSL---------GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVV 790
Query: 553 ARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
A DG V T + I V+D++DN PVF YT + E+ GT++ Q+ A D D+G
Sbjct: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKAL------DRESVATHDLKAVAIDGGTPP 666
N + Y + + + F + P +G + ++L D+E+ T ++A I G PP
Sbjct: 851 N--VSYRIRSPEVKH-FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 907
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+TV V +K D+ND PPVF ++ ++ GT I + A D D
Sbjct: 908 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Score = 192 bits (467), Expect = 2e-47
Identities = 178/623 (28%), Positives = 287/623 (46%), Gaps = 63/623 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-------- 434
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
DT +PE VF + G + L +DRE+ YT + A D
Sbjct: 435 DTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 490 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 542
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 543 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
Query: 244 LINIRDVNDNAP-RFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ +P RF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 654
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+DG P ++TAT
Sbjct: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTDVNDN 713
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGR 420
F P +E V + ATD D + ++HY + GN F ITS
Sbjct: 714 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN--- 768
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 829 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 879
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P T V + V D+ND PVF +++Y +
Sbjct: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAP 937
Query: 593 DALVGTSVSQVGATDADVGLNGR 615
DA+ GT ++ V A DAD ++ R
Sbjct: 938 DAVKGTPITTVYAEDADPPVSRR 960
Score = 160 bits (388), Expect = 8e-38
Identities = 182/695 (26%), Positives = 296/695 (42%), Gaps = 65/695 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSGYLLTVTARDGGV 558
I + E+ + + + F + QTG +T + +DRE Y ++TA DG
Sbjct: 431 KDIEDTKDPEL-HLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G NG I Y
Sbjct: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
E+ +G F+I+ +G+I ++ T+ L A D P + I + IE
Sbjct: 547 EI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Query: 679 DI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
+ N SPP F + ISE +G + ++A D EG + + Y+I+ GD F
Sbjct: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGDPQRVF 661
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVNDNAPV 793
+L G L LD ES +Y L+I A+ P + V I+VTDVNDNAPV
Sbjct: 662 NLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
Query: 794 MKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMTLSP 853
+ + + G+V A D D Q GN NL + + GS+ +
Sbjct: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAV 775
Query: 854 QLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+LN V + V TDG V+ + + L+++++
Sbjct: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 810
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL834258-1|CAD38933.1| 1084|Homo sapiens hypothetical protein
protein.
Length = 1084
Score = 267 bits (654), Expect = 4e-70
Identities = 179/583 (30%), Positives = 285/583 (48%), Gaps = 29/583 (4%)
Query: 176 ATDADVGANSAIRYAIIGGNTQMQFSI-DSLSGD----VSLVKTLDYEQVRSYRLVIRAQ 230
ATD D G N Y ++ G + I ++ G+ + + + LD EQ +Y + I+ +
Sbjct: 13 ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE 72
Query: 231 DGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNA 290
DGG+P +S+T L + + DVNDN P F + + EN P+G S++++ A DAD G NA
Sbjct: 73 DGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNA 132
Query: 291 ELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATA 350
E+ Y + L ++ +G + LDRE A +++ V A+DG P AT
Sbjct: 133 EIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATV 191
Query: 351 TXXXXXXX----XXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG 406
T P V L+E +P T + +T +D D D I
Sbjct: 192 TINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVN-GKVICFI 250
Query: 407 NTRGRFSITS-QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDAN 463
F + + + + L+ + LD++ + + + A+DSG S TA+V++ + D N
Sbjct: 251 EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDEN 310
Query: 464 NYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQ 523
+ P+F SV E+ G + +SATD D G NA I Y L S
Sbjct: 311 DNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS---------F 361
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQ 583
F ++ +TG +T +++ DRE ++ TVTARD G P L V ++V+D NDN P F
Sbjct: 362 FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTH 421
Query: 584 QLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNK 643
+ + E+ ++V + TDAD G N + + + +FV+DP SGVI++N
Sbjct: 422 NHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSI---LNDNDNFVLDPYSGVIKSNV 478
Query: 644 ALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES--DCLTFYISENSP 701
+ DRE +++ A DGG PP+SST V I + D+ND+ PV S +F + S
Sbjct: 479 SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSA 538
Query: 702 I-GTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
I G+ + E+ A D D G NA + Y+I G++ F ++ G+
Sbjct: 539 IPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGN 581
Score = 243 bits (594), Expect = 8e-63
Identities = 182/615 (29%), Positives = 284/615 (46%), Gaps = 47/615 (7%)
Query: 281 AYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTA 338
A D D G N Y + + +D+ T + W + LDRE + Y + +
Sbjct: 13 ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEK-WPQLIVQQNLDREQKDTYVMKIKV 71
Query: 339 TDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR 398
DGG P +S+TA F GQ EV + E+ P GT V+ L ATDAD +
Sbjct: 72 EDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSN 131
Query: 399 LHYEITGGN-----TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTA 453
G T+ F++ N GLITV + LD ++ + +TV A+D A
Sbjct: 132 AEIRYIFGAQVAPATKRLFALN--NTTGLITVQRSLDREETAIHKVTVLASDGSSTPARA 189
Query: 454 MVQINITDANNYAPVFEN----APYTASVF--EDAPIGTTVLVVSATDSDVGINAQITYS 507
V IN+TD N+ P + +P +V+ E P+ T + +++ +D D +N ++
Sbjct: 190 TVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICF 249
Query: 508 LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV 567
+ E+ A +D Q+++ T+ LLD E + + A D G PSL+ T V
Sbjct: 250 IEREVPFHLKAVYDNQYLLE-------TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALV 302
Query: 568 EISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE 627
+ + D NDN P+F Q + ++ E+ G ++ + ATD D G N I Y+L P
Sbjct: 303 RVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPN---A 359
Query: 628 GSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF 687
F +D +GV+ ++ DRE A D GTPP S V + + D ND+ P F
Sbjct: 360 SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKF 419
Query: 688 ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE 747
+ F++SEN P +T+G I D D G N V SI +D+++F L+ G K+
Sbjct: 420 THNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSIL--NDNDNFVLDPYSGVIKSN 477
Query: 748 LVTMVDLDYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVM------KDFQ 798
V D E + Y ++A PP + +V I V DVNDN+PV+ F+
Sbjct: 478 ----VSFDREQ-QSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFK 532
Query: 799 IIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLN 856
++ P V A D D + +L+Y I+SGNN L ++ TG++TL +
Sbjct: 533 LV---PLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPA 589
Query: 857 TNVPKLATMEVSVTD 871
L + V+++D
Sbjct: 590 PTDVGLHRLVVNISD 604
Score = 235 bits (575), Expect = 2e-60
Identities = 174/597 (29%), Positives = 287/597 (48%), Gaps = 40/597 (6%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + +LDRE+ Y + +K D +P + SSTA + V + D NDN P F E V
Sbjct: 51 LIVQQNLDREQKDTYVMKIKVEDGGTP---QKSSTAILQVTVSDVNDNRPVFKEGQVEVH 107
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRY---AIIGGNTQMQFSIDSLSGDVSLVKTL 215
+ E+ V + + ++ ATDAD+G+N+ IRY A + T+ F++++ +G +++ ++L
Sbjct: 108 IPENAPVGTS--VIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 165
Query: 216 DYEQVRSYRLVIRAQDGGS-PSRSNTTQLLINIRDVNDNAP----RFYTSLFQESV--SE 268
D E+ +++ + A DG S P+R+ T IN+ DVNDN P R+ S +V SE
Sbjct: 166 DREETAIHKVTVLASDGSSTPARATVT---INVTDVNDNPPNIDLRYIISPINGTVYLSE 222
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRET 328
P+ I + D D VN ++ +++ ++ + + TS LD E
Sbjct: 223 KDPVNTKIALITVSDKDTDVNGKV-ICFIEREVPFHLK---AVYDNQYLLETSSLLDYEG 278
Query: 329 QAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTL 388
++ + A+D G P + TA F E+ ++E+ G + T+
Sbjct: 279 TKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTI 338
Query: 389 TATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG- 447
+ATD D G F + + G++T ++ D +++ R++ TV+A D+G
Sbjct: 339 SATDEDSGKNADIVYQLGPNASFFDLDRKT--GVLTASRVFDREEQERFIFTVTARDNGT 396
Query: 448 -GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITY 506
A V + + D N+ +P F + + V E+ P +TV V++ TD+D G N +T
Sbjct: 397 PPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTL 456
Query: 507 SLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTD 566
S+ ++ N FV++P +G I +N DRE S Y V A DGG P S T
Sbjct: 457 SILNDNDN---------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAK 507
Query: 567 VEISVVDVNDNEPVFKQQLYTAN---IMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
V I+V+DVNDN PV + + A+ G+ V++V A D D G+N + Y +
Sbjct: 508 VTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTI-VS 566
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST-VIVHIKIED 679
+G F IDP +G I + V H L D G P T V+V + + D
Sbjct: 567 GNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVND 623
Score = 206 bits (502), Expect = 1e-51
Identities = 171/582 (29%), Positives = 264/582 (45%), Gaps = 54/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q+ V D ND+ PVF+ Q E + E A GT+V+ L ATD DIG NAE+ Y A
Sbjct: 86 QVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPA 145
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + SLDRE+ A + V V A+D +S
Sbjct: 146 ----------------TKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS----- 184
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD----NPVIAKIKATDADVGANS 185
+ AT+ +N+ D NDN P + ++ + +++ N IA I +D D N
Sbjct: 185 TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNG 244
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ I ++ F + ++ + L++T LDYE + + I A D G PS + T
Sbjct: 245 KVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL 301
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D NDN P F + + SVSEN G + + A D D G NA++ Y +
Sbjct: 302 VRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGP---- 357
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
N +D ++G + S DRE Q ++ VTA D G PP + A
Sbjct: 358 -NASF-FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDN 415
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F ++ ++E+ P + V +T TDAD ++ N F + + G+
Sbjct: 416 SPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYS--GV 473
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
I D +Q+ Y V ATD G RS TA V IN+ D N+ +PV + P S F+
Sbjct: 474 IKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTS-FK 532
Query: 481 DAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
P+ G+ V V A D D G+NA++ Y++ S +N+ + F I+P TG IT
Sbjct: 533 LVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSG-NNKGL------FRIDPVTGNITLE 585
Query: 537 KLLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDN 577
+ + + L V D G P SL V + V D N
Sbjct: 586 EKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGN 627
Score = 146 bits (353), Expect = 1e-33
Identities = 121/418 (28%), Positives = 190/418 (45%), Gaps = 33/418 (7%)
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA---ITTNKLLDRETMSG 546
+ SATD D G N Y L ++ ++V D V P+ + + LDRE
Sbjct: 10 IPSATDPDTGFNGVQHYEL---LNGQSVFGLD--IVETPEGEKWPQLIVQQNLDREQKDT 64
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
Y++ + DGG P S T ++++V DVNDN PVFK+ +I E+A VGTSV Q+ AT
Sbjct: 65 YVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHAT 124
Query: 607 DADVGLNGRIHYELDPK--DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGT 664
DAD+G N I Y + + F ++ +G+I ++LDRE A H + +A DG +
Sbjct: 125 DADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSS 184
Query: 665 PPQSSTVIVHIKIEDINDSPPVFESDCL------TFYISENSPIGTTIGEIRAHDPDEGP 718
P +TV I + D+ND+PP + + T Y+SE P+ T I I D D
Sbjct: 185 TPARATVT--INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDV 242
Query: 719 NAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAASPPLWND 777
N V I + F L+ ++ L T LDYE ++ +++V + P N
Sbjct: 243 NGKVICFI---EREVPFHLKAVY-DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQ 298
Query: 778 VR-VEILVTDVNDNAPVMK----DFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRIL 832
V + + D NDN P+ + + NN + + + A D D
Sbjct: 299 TALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLY----LTTISATDEDSGKNADIVYQ 354
Query: 833 SGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
G NA+ L+ TG +T S + + V+ D G +++ + V ++ E
Sbjct: 355 LGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 412
Score = 108 bits (260), Expect = 2e-22
Identities = 80/250 (32%), Positives = 119/250 (47%), Gaps = 26/250 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F ++ V E +TV + TD D G+N + VT L
Sbjct: 407 VTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGEN-------KAVTLSIL 459
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D F +D SG + + S DRE+ + YT VKATD P
Sbjct: 460 NDNDN--------------FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR--- 502
Query: 131 SSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SSTA + +N++D NDN P S + T +S V+A++ A D D G N+ ++Y
Sbjct: 503 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKY 562
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL-INIR 248
I+ GN + F ID ++G+++L + V +RLV+ D G P +T L+ + +
Sbjct: 563 TIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVN 622
Query: 249 DVNDNAPRFY 258
D NA Y
Sbjct: 623 DTAGNASYIY 632
Score = 98.3 bits (234), Expect = 3e-19
Identities = 64/204 (31%), Positives = 96/204 (47%), Gaps = 5/204 (2%)
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG----VIRTNKALDRE 648
+ L+ + ATD D G NG HYEL G +++ G + + LDRE
Sbjct: 1 NTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDRE 60
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
T+ +K DGGTP +SST I+ + + D+ND+ PVF+ + +I EN+P+GT++ +
Sbjct: 61 QKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQ 120
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
+ A D D G NA + Y I G + + + + LD E V+
Sbjct: 121 LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA 179
Query: 769 AASPPLWNDVRVEILVTDVNDNAP 792
+ V I VTDVNDN P
Sbjct: 180 SDGSSTPARATVTINVTDVNDNPP 203
>AL365496-3|CAM19868.1| 1785|Homo sapiens protocadherin 15 protein.
Length = 1785
Score = 267 bits (654), Expect = 4e-70
Identities = 257/843 (30%), Positives = 388/843 (46%), Gaps = 103/843 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDAD-EGVNAELTYTMTDK------DYTGNVDLPITIDPRSGWVYTSGQ 323
+R+ A D D E V T + DYT +T + ++
Sbjct: 418 LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQP 475
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
+DRE Q Y +TA DG S F Y+V + D PG
Sbjct: 476 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 533
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
V+ LTA DADE + + YEI G +G F I GLIT+A ++ R Y LTV
Sbjct: 534 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTV 590
Query: 442 SATDSG----GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDS 496
A D+ R+ V I + NN +P F Y+ + E +G +L + ATD
Sbjct: 591 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 650
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
+ ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG
Sbjct: 651 E---GDSITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG 700
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
P + T V I V DVNDN PVF L + + V QV ATD D G+NG++
Sbjct: 701 R-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 759
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
HY L F I ++G I T L+RE ++L VA DG P+ ST+ + IK
Sbjct: 760 HYSL---GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 677 IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
+ DI+D+ PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+
Sbjct: 816 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 873
Query: 737 LETRQGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDN 790
L G EL + LDYE+ P ++ + + ++ + V ++V D+ND
Sbjct: 874 LHPFTG----ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 929
Query: 791 APV 793
PV
Sbjct: 930 PPV 932
Score = 230 bits (563), Expect = 5e-59
Identities = 237/856 (27%), Positives = 380/856 (44%), Gaps = 81/856 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E +
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-DVPPSGV 441
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
T +PE VF + G + L +DRE+ YT + A D
Sbjct: 442 PTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 496
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 497 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 549
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 550 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 608
Query: 244 LINIRDVNDNA-PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ + PRF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 609 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 661
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+D G P ++TAT
Sbjct: 662 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 720
Query: 363 XXXFMPG-QYEVELAEDEPPG-TPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR 420
F P + + E+E V T DA + ++HY + GN F ITS
Sbjct: 721 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---N 775
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 776 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 835
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 836 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 886
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P V + V D+ND PVF +++Y +
Sbjct: 887 LDYEAFPDQEASITFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 944
Query: 593 DALVGTSVSQVGATDAD-VGL-NGRIHYELDPKD--REEGSFVIDPASGVIRTNKALDRE 648
DA+ GT ++ V A DAD GL R+ Y +D F ++ SG + T L+ E
Sbjct: 945 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1004
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
L VA D G P SS+ V I + + P + + +SE + GT +G
Sbjct: 1005 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1064
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I A N + YSI G++ ++F + G + LDYE+ R Y L ++
Sbjct: 1065 ISA----AAINQSIVYSIVSGNEEDTFGINNITG----VIYVNGPLDYET-RTSYVLRVQ 1115
Query: 769 AAS----------PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA 818
A S P N +V I + D N++ PV + I +D RV A
Sbjct: 1116 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1175
Query: 819 YDADVTD--KLQYRIL 832
D D + + YR++
Sbjct: 1176 TDKDTGNYSVMAYRLI 1191
Score = 200 bits (488), Expect = 6e-50
Identities = 209/786 (26%), Positives = 340/786 (43%), Gaps = 95/786 (12%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD-----------EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
A D D +D LH + + F++T +T+ QP+D ++++ Y
Sbjct: 427 VALDKDIEDVPPSGVPTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTY 484
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
+++A D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D
Sbjct: 485 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 544
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G N +ITY E + F+IN TG IT ++ Y LTV A D
Sbjct: 545 EGSNGEITY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 596
Query: 558 VPS--LSDTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
P+ + V I V+ N+ P F Q +Y+ I E VG + + ATD +
Sbjct: 597 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 653
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
I Y ++ D + F + +G++ KALDRES + L A D G P +ST V+
Sbjct: 654 SITYAIENGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 711
Query: 675 IKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS 734
I + D+ND+ PVF+ +G+++A DPD G N VHYS+ G+ +N
Sbjct: 712 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 769
Query: 735 FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNA 791
F + T GS + T V L+ E R YELV+ A A P + + + I V D++DN+
Sbjct: 770 FRI-TSNGS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 823
Query: 792 PVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
PV + ++ P G ++ A D D+ + YRI S + L+ TG ++
Sbjct: 824 PVFTNSTYTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 882
Query: 851 LSPQLN 856
L L+
Sbjct: 883 LLRSLD 888
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 610 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 660
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 661 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 704
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 705 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 760
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 761 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 818 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 871
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 872 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 929
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 930 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 990 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1047 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1095
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1096 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1155
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1156 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1213
Score = 156 bits (379), Expect = 9e-37
Identities = 184/700 (26%), Positives = 294/700 (42%), Gaps = 68/700 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHH----DQQFVIN-PQTGA---ITTNKLLDRETMSGYLLTVTA 553
I S + + H D V QTG +T + +DRE Y ++TA
Sbjct: 431 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 490
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
DG S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G N
Sbjct: 491 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 548
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
G I YE+ +G F+I+ +G+I ++ T+ L A D P + I
Sbjct: 549 GEITYEI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 606
Query: 674 HIKIEDI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGD 730
+ IE + N SPP F + ISE +G + ++A D EG + + Y+I+ GD
Sbjct: 607 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGD 663
Query: 731 DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVN 788
F+L G L LD ES +Y L+I A+ P + V I+VTDVN
Sbjct: 664 PQRVFNLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVN 718
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGS 848
DNAPV + + + G+V A D D Q GN NL + + GS
Sbjct: 719 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGS 777
Query: 849 MTLSPQLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+ + +LN V + V TDG V+ + + L+++++
Sbjct: 778 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL365496-1|CAM19866.1| 1684|Homo sapiens protocadherin 15 protein.
Length = 1684
Score = 267 bits (654), Expect = 4e-70
Identities = 257/843 (30%), Positives = 388/843 (46%), Gaps = 103/843 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDAD-EGVNAELTYTMTDK------DYTGNVDLPITIDPRSGWVYTSGQ 323
+R+ A D D E V T + DYT +T + ++
Sbjct: 418 LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQP 475
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
+DRE Q Y +TA DG S F Y+V + D PG
Sbjct: 476 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 533
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
V+ LTA DADE + + YEI G +G F I GLIT+A ++ R Y LTV
Sbjct: 534 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTV 590
Query: 442 SATDSG----GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDS 496
A D+ R+ V I + NN +P F Y+ + E +G +L + ATD
Sbjct: 591 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 650
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
+ ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG
Sbjct: 651 E---GDSITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG 700
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
P + T V I V DVNDN PVF L + + V QV ATD D G+NG++
Sbjct: 701 R-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 759
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
HY L F I ++G I T L+RE ++L VA DG P+ ST+ + IK
Sbjct: 760 HYSL---GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 677 IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
+ DI+D+ PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+
Sbjct: 816 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 873
Query: 737 LETRQGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDN 790
L G EL + LDYE+ P ++ + + ++ + V ++V D+ND
Sbjct: 874 LHPFTG----ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 929
Query: 791 APV 793
PV
Sbjct: 930 PPV 932
Score = 230 bits (563), Expect = 5e-59
Identities = 237/856 (27%), Positives = 380/856 (44%), Gaps = 81/856 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E +
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-DVPPSGV 441
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
T +PE VF + G + L +DRE+ YT + A D
Sbjct: 442 PTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 496
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 497 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 549
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 550 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 608
Query: 244 LINIRDVNDNA-PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ + PRF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 609 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 661
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+D G P ++TAT
Sbjct: 662 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 720
Query: 363 XXXFMPG-QYEVELAEDEPPG-TPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR 420
F P + + E+E V T DA + ++HY + GN F ITS
Sbjct: 721 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---N 775
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 776 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 835
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 836 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 886
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P V + V D+ND PVF +++Y +
Sbjct: 887 LDYEAFPDQEASITFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 944
Query: 593 DALVGTSVSQVGATDAD-VGL-NGRIHYELDPKD--REEGSFVIDPASGVIRTNKALDRE 648
DA+ GT ++ V A DAD GL R+ Y +D F ++ SG + T L+ E
Sbjct: 945 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1004
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
L VA D G P SS+ V I + + P + + +SE + GT +G
Sbjct: 1005 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1064
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I A N + YSI G++ ++F + G + LDYE+ R Y L ++
Sbjct: 1065 ISA----AAINQSIVYSIVSGNEEDTFGINNITG----VIYVNGPLDYET-RTSYVLRVQ 1115
Query: 769 AAS----------PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA 818
A S P N +V I + D N++ PV + I +D RV A
Sbjct: 1116 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1175
Query: 819 YDADVTD--KLQYRIL 832
D D + + YR++
Sbjct: 1176 TDKDTGNYSVMAYRLI 1191
Score = 200 bits (488), Expect = 6e-50
Identities = 209/786 (26%), Positives = 340/786 (43%), Gaps = 95/786 (12%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD-----------EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
A D D +D LH + + F++T +T+ QP+D ++++ Y
Sbjct: 427 VALDKDIEDVPPSGVPTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTY 484
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
+++A D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D
Sbjct: 485 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 544
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G N +ITY E + F+IN TG IT ++ Y LTV A D
Sbjct: 545 EGSNGEITY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 596
Query: 558 VPS--LSDTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
P+ + V I V+ N+ P F Q +Y+ I E VG + + ATD +
Sbjct: 597 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 653
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
I Y ++ D + F + +G++ KALDRES + L A D G P +ST V+
Sbjct: 654 SITYAIENGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 711
Query: 675 IKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS 734
I + D+ND+ PVF+ +G+++A DPD G N VHYS+ G+ +N
Sbjct: 712 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 769
Query: 735 FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNA 791
F + T GS + T V L+ E R YELV+ A A P + + + I V D++DN+
Sbjct: 770 FRI-TSNGS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 823
Query: 792 PVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
PV + ++ P G ++ A D D+ + YRI S + L+ TG ++
Sbjct: 824 PVFTNSTYTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 882
Query: 851 LSPQLN 856
L L+
Sbjct: 883 LLRSLD 888
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 610 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 660
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 661 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 704
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 705 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 760
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 761 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 818 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 871
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 872 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 929
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 930 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 990 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1047 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1095
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1096 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1155
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1156 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1213
Score = 156 bits (379), Expect = 9e-37
Identities = 184/700 (26%), Positives = 294/700 (42%), Gaps = 68/700 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHH----DQQFVIN-PQTGA---ITTNKLLDRETMSGYLLTVTA 553
I S + + H D V QTG +T + +DRE Y ++TA
Sbjct: 431 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 490
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
DG S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G N
Sbjct: 491 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 548
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
G I YE+ +G F+I+ +G+I ++ T+ L A D P + I
Sbjct: 549 GEITYEI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 606
Query: 674 HIKIEDI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGD 730
+ IE + N SPP F + ISE +G + ++A D EG + + Y+I+ GD
Sbjct: 607 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGD 663
Query: 731 DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVN 788
F+L G L LD ES +Y L+I A+ P + V I+VTDVN
Sbjct: 664 PQRVFNLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVN 718
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGS 848
DNAPV + + + G+V A D D Q GN NL + + GS
Sbjct: 719 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGS 777
Query: 849 MTLSPQLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+ + +LN V + V TDG V+ + + L+++++
Sbjct: 778 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL360214-6|CAM21538.1| 1785|Homo sapiens protocadherin 15 protein.
Length = 1785
Score = 267 bits (654), Expect = 4e-70
Identities = 257/843 (30%), Positives = 388/843 (46%), Gaps = 103/843 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDAD-EGVNAELTYTMTDK------DYTGNVDLPITIDPRSGWVYTSGQ 323
+R+ A D D E V T + DYT +T + ++
Sbjct: 418 LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQP 475
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
+DRE Q Y +TA DG S F Y+V + D PG
Sbjct: 476 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 533
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
V+ LTA DADE + + YEI G +G F I GLIT+A ++ R Y LTV
Sbjct: 534 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTV 590
Query: 442 SATDSG----GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDS 496
A D+ R+ V I + NN +P F Y+ + E +G +L + ATD
Sbjct: 591 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 650
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
+ ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG
Sbjct: 651 E---GDSITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG 700
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
P + T V I V DVNDN PVF L + + V QV ATD D G+NG++
Sbjct: 701 R-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 759
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
HY L F I ++G I T L+RE ++L VA DG P+ ST+ + IK
Sbjct: 760 HYSL---GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 677 IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
+ DI+D+ PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+
Sbjct: 816 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 873
Query: 737 LETRQGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDN 790
L G EL + LDYE+ P ++ + + ++ + V ++V D+ND
Sbjct: 874 LHPFTG----ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 929
Query: 791 APV 793
PV
Sbjct: 930 PPV 932
Score = 230 bits (563), Expect = 5e-59
Identities = 237/856 (27%), Positives = 380/856 (44%), Gaps = 81/856 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E +
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-DVPPSGV 441
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
T +PE VF + G + L +DRE+ YT + A D
Sbjct: 442 PTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 496
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 497 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 549
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 550 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 608
Query: 244 LINIRDVNDNA-PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ + PRF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 609 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 661
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+D G P ++TAT
Sbjct: 662 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 720
Query: 363 XXXFMPG-QYEVELAEDEPPG-TPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR 420
F P + + E+E V T DA + ++HY + GN F ITS
Sbjct: 721 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---N 775
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 776 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 835
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 836 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 886
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P V + V D+ND PVF +++Y +
Sbjct: 887 LDYEAFPDQEASITFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 944
Query: 593 DALVGTSVSQVGATDAD-VGL-NGRIHYELDPKD--REEGSFVIDPASGVIRTNKALDRE 648
DA+ GT ++ V A DAD GL R+ Y +D F ++ SG + T L+ E
Sbjct: 945 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1004
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
L VA D G P SS+ V I + + P + + +SE + GT +G
Sbjct: 1005 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1064
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I A N + YSI G++ ++F + G + LDYE+ R Y L ++
Sbjct: 1065 ISA----AAINQSIVYSIVSGNEEDTFGINNITG----VIYVNGPLDYET-RTSYVLRVQ 1115
Query: 769 AAS----------PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA 818
A S P N +V I + D N++ PV + I +D RV A
Sbjct: 1116 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1175
Query: 819 YDADVTD--KLQYRIL 832
D D + + YR++
Sbjct: 1176 TDKDTGNYSVMAYRLI 1191
Score = 200 bits (488), Expect = 6e-50
Identities = 209/786 (26%), Positives = 340/786 (43%), Gaps = 95/786 (12%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD-----------EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
A D D +D LH + + F++T +T+ QP+D ++++ Y
Sbjct: 427 VALDKDIEDVPPSGVPTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTY 484
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
+++A D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D
Sbjct: 485 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 544
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G N +ITY E + F+IN TG IT ++ Y LTV A D
Sbjct: 545 EGSNGEITY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 596
Query: 558 VPS--LSDTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
P+ + V I V+ N+ P F Q +Y+ I E VG + + ATD +
Sbjct: 597 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 653
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
I Y ++ D + F + +G++ KALDRES + L A D G P +ST V+
Sbjct: 654 SITYAIENGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 711
Query: 675 IKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS 734
I + D+ND+ PVF+ +G+++A DPD G N VHYS+ G+ +N
Sbjct: 712 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 769
Query: 735 FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNA 791
F + T GS + T V L+ E R YELV+ A A P + + + I V D++DN+
Sbjct: 770 FRI-TSNGS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 823
Query: 792 PVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
PV + ++ P G ++ A D D+ + YRI S + L+ TG ++
Sbjct: 824 PVFTNSTYTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 882
Query: 851 LSPQLN 856
L L+
Sbjct: 883 LLRSLD 888
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 610 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 660
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 661 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 704
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 705 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 760
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 761 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 818 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 871
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 872 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 929
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 930 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 990 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1047 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1095
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1096 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1155
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1156 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1213
Score = 156 bits (379), Expect = 9e-37
Identities = 184/700 (26%), Positives = 294/700 (42%), Gaps = 68/700 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHH----DQQFVIN-PQTGA---ITTNKLLDRETMSGYLLTVTA 553
I S + + H D V QTG +T + +DRE Y ++TA
Sbjct: 431 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 490
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
DG S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G N
Sbjct: 491 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 548
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
G I YE+ +G F+I+ +G+I ++ T+ L A D P + I
Sbjct: 549 GEITYEI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 606
Query: 674 HIKIEDI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGD 730
+ IE + N SPP F + ISE +G + ++A D EG + + Y+I+ GD
Sbjct: 607 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGD 663
Query: 731 DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVN 788
F+L G L LD ES +Y L+I A+ P + V I+VTDVN
Sbjct: 664 PQRVFNLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVN 718
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGS 848
DNAPV + + + G+V A D D Q GN NL + + GS
Sbjct: 719 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGS 777
Query: 849 MTLSPQLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+ + +LN V + V TDG V+ + + L+++++
Sbjct: 778 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL360214-4|CAM21536.1| 1684|Homo sapiens protocadherin 15 protein.
Length = 1684
Score = 267 bits (654), Expect = 4e-70
Identities = 257/843 (30%), Positives = 388/843 (46%), Gaps = 103/843 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDAD-EGVNAELTYTMTDK------DYTGNVDLPITIDPRSGWVYTSGQ 323
+R+ A D D E V T + DYT +T + ++
Sbjct: 418 LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQP 475
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
+DRE Q Y +TA DG S F Y+V + D PG
Sbjct: 476 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 533
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
V+ LTA DADE + + YEI G +G F I GLIT+A ++ R Y LTV
Sbjct: 534 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTV 590
Query: 442 SATDSG----GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDS 496
A D+ R+ V I + NN +P F Y+ + E +G +L + ATD
Sbjct: 591 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 650
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
+ ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG
Sbjct: 651 E---GDSITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG 700
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
P + T V I V DVNDN PVF L + + V QV ATD D G+NG++
Sbjct: 701 R-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 759
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
HY L F I ++G I T L+RE ++L VA DG P+ ST+ + IK
Sbjct: 760 HYSL---GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 677 IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
+ DI+D+ PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+
Sbjct: 816 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 873
Query: 737 LETRQGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDN 790
L G EL + LDYE+ P ++ + + ++ + V ++V D+ND
Sbjct: 874 LHPFTG----ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 929
Query: 791 APV 793
PV
Sbjct: 930 PPV 932
Score = 230 bits (563), Expect = 5e-59
Identities = 237/856 (27%), Positives = 380/856 (44%), Gaps = 81/856 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E +
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-DVPPSGV 441
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
T +PE VF + G + L +DRE+ YT + A D
Sbjct: 442 PTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 496
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 497 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 549
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 550 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 608
Query: 244 LINIRDVNDNA-PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ + PRF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 609 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 661
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+D G P ++TAT
Sbjct: 662 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 720
Query: 363 XXXFMPG-QYEVELAEDEPPG-TPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR 420
F P + + E+E V T DA + ++HY + GN F ITS
Sbjct: 721 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---N 775
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 776 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 835
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 836 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 886
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P V + V D+ND PVF +++Y +
Sbjct: 887 LDYEAFPDQEASITFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 944
Query: 593 DALVGTSVSQVGATDAD-VGL-NGRIHYELDPKD--REEGSFVIDPASGVIRTNKALDRE 648
DA+ GT ++ V A DAD GL R+ Y +D F ++ SG + T L+ E
Sbjct: 945 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1004
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
L VA D G P SS+ V I + + P + + +SE + GT +G
Sbjct: 1005 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1064
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I A N + YSI G++ ++F + G + LDYE+ R Y L ++
Sbjct: 1065 ISA----AAINQSIVYSIVSGNEEDTFGINNITG----VIYVNGPLDYET-RTSYVLRVQ 1115
Query: 769 AAS----------PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA 818
A S P N +V I + D N++ PV + I +D RV A
Sbjct: 1116 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1175
Query: 819 YDADVTD--KLQYRIL 832
D D + + YR++
Sbjct: 1176 TDKDTGNYSVMAYRLI 1191
Score = 200 bits (488), Expect = 6e-50
Identities = 209/786 (26%), Positives = 340/786 (43%), Gaps = 95/786 (12%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD-----------EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
A D D +D LH + + F++T +T+ QP+D ++++ Y
Sbjct: 427 VALDKDIEDVPPSGVPTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTY 484
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
+++A D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D
Sbjct: 485 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 544
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G N +ITY E + F+IN TG IT ++ Y LTV A D
Sbjct: 545 EGSNGEITY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 596
Query: 558 VPS--LSDTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
P+ + V I V+ N+ P F Q +Y+ I E VG + + ATD +
Sbjct: 597 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 653
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
I Y ++ D + F + +G++ KALDRES + L A D G P +ST V+
Sbjct: 654 SITYAIENGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 711
Query: 675 IKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS 734
I + D+ND+ PVF+ +G+++A DPD G N VHYS+ G+ +N
Sbjct: 712 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 769
Query: 735 FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNA 791
F + T GS + T V L+ E R YELV+ A A P + + + I V D++DN+
Sbjct: 770 FRI-TSNGS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 823
Query: 792 PVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
PV + ++ P G ++ A D D+ + YRI S + L+ TG ++
Sbjct: 824 PVFTNSTYTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 882
Query: 851 LSPQLN 856
L L+
Sbjct: 883 LLRSLD 888
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 610 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 660
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 661 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 704
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 705 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 760
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 761 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 818 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 871
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 872 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 929
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 930 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 990 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1047 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1095
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1096 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1155
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1156 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1213
Score = 156 bits (379), Expect = 9e-37
Identities = 184/700 (26%), Positives = 294/700 (42%), Gaps = 68/700 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHH----DQQFVIN-PQTGA---ITTNKLLDRETMSGYLLTVTA 553
I S + + H D V QTG +T + +DRE Y ++TA
Sbjct: 431 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 490
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
DG S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G N
Sbjct: 491 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 548
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
G I YE+ +G F+I+ +G+I ++ T+ L A D P + I
Sbjct: 549 GEITYEI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 606
Query: 674 HIKIEDI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGD 730
+ IE + N SPP F + ISE +G + ++A D EG + + Y+I+ GD
Sbjct: 607 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGD 663
Query: 731 DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVN 788
F+L G L LD ES +Y L+I A+ P + V I+VTDVN
Sbjct: 664 PQRVFNLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVN 718
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGS 848
DNAPV + + + G+V A D D Q GN NL + + GS
Sbjct: 719 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGS 777
Query: 849 MTLSPQLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+ + +LN V + V TDG V+ + + L+++++
Sbjct: 778 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL356114-6|CAM15119.1| 1785|Homo sapiens protocadherin 15 protein.
Length = 1785
Score = 267 bits (654), Expect = 4e-70
Identities = 257/843 (30%), Positives = 388/843 (46%), Gaps = 103/843 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDAD-EGVNAELTYTMTDK------DYTGNVDLPITIDPRSGWVYTSGQ 323
+R+ A D D E V T + DYT +T + ++
Sbjct: 418 LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQP 475
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
+DRE Q Y +TA DG S F Y+V + D PG
Sbjct: 476 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 533
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
V+ LTA DADE + + YEI G +G F I GLIT+A ++ R Y LTV
Sbjct: 534 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTV 590
Query: 442 SATDSG----GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDS 496
A D+ R+ V I + NN +P F Y+ + E +G +L + ATD
Sbjct: 591 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 650
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
+ ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG
Sbjct: 651 E---GDSITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG 700
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
P + T V I V DVNDN PVF L + + V QV ATD D G+NG++
Sbjct: 701 R-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 759
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
HY L F I ++G I T L+RE ++L VA DG P+ ST+ + IK
Sbjct: 760 HYSL---GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 677 IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
+ DI+D+ PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+
Sbjct: 816 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 873
Query: 737 LETRQGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDN 790
L G EL + LDYE+ P ++ + + ++ + V ++V D+ND
Sbjct: 874 LHPFTG----ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 929
Query: 791 APV 793
PV
Sbjct: 930 PPV 932
Score = 230 bits (563), Expect = 5e-59
Identities = 237/856 (27%), Positives = 380/856 (44%), Gaps = 81/856 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E +
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-DVPPSGV 441
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
T +PE VF + G + L +DRE+ YT + A D
Sbjct: 442 PTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 496
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 497 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 549
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 550 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 608
Query: 244 LINIRDVNDNA-PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ + PRF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 609 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 661
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+D G P ++TAT
Sbjct: 662 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 720
Query: 363 XXXFMPG-QYEVELAEDEPPG-TPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR 420
F P + + E+E V T DA + ++HY + GN F ITS
Sbjct: 721 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---N 775
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 776 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 835
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 836 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 886
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P V + V D+ND PVF +++Y +
Sbjct: 887 LDYEAFPDQEASITFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 944
Query: 593 DALVGTSVSQVGATDAD-VGL-NGRIHYELDPKD--REEGSFVIDPASGVIRTNKALDRE 648
DA+ GT ++ V A DAD GL R+ Y +D F ++ SG + T L+ E
Sbjct: 945 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1004
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
L VA D G P SS+ V I + + P + + +SE + GT +G
Sbjct: 1005 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1064
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I A N + YSI G++ ++F + G + LDYE+ R Y L ++
Sbjct: 1065 ISA----AAINQSIVYSIVSGNEEDTFGINNITG----VIYVNGPLDYET-RTSYVLRVQ 1115
Query: 769 AAS----------PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA 818
A S P N +V I + D N++ PV + I +D RV A
Sbjct: 1116 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1175
Query: 819 YDADVTD--KLQYRIL 832
D D + + YR++
Sbjct: 1176 TDKDTGNYSVMAYRLI 1191
Score = 200 bits (488), Expect = 6e-50
Identities = 209/786 (26%), Positives = 340/786 (43%), Gaps = 95/786 (12%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD-----------EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
A D D +D LH + + F++T +T+ QP+D ++++ Y
Sbjct: 427 VALDKDIEDVPPSGVPTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTY 484
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
+++A D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D
Sbjct: 485 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 544
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G N +ITY E + F+IN TG IT ++ Y LTV A D
Sbjct: 545 EGSNGEITY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 596
Query: 558 VPS--LSDTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
P+ + V I V+ N+ P F Q +Y+ I E VG + + ATD +
Sbjct: 597 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 653
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
I Y ++ D + F + +G++ KALDRES + L A D G P +ST V+
Sbjct: 654 SITYAIENGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 711
Query: 675 IKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS 734
I + D+ND+ PVF+ +G+++A DPD G N VHYS+ G+ +N
Sbjct: 712 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 769
Query: 735 FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNA 791
F + T GS + T V L+ E R YELV+ A A P + + + I V D++DN+
Sbjct: 770 FRI-TSNGS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 823
Query: 792 PVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
PV + ++ P G ++ A D D+ + YRI S + L+ TG ++
Sbjct: 824 PVFTNSTYTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 882
Query: 851 LSPQLN 856
L L+
Sbjct: 883 LLRSLD 888
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 610 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 660
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 661 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 704
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 705 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 760
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 761 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 818 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 871
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 872 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 929
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 930 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 990 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1047 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1095
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1096 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1155
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1156 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1213
Score = 156 bits (379), Expect = 9e-37
Identities = 184/700 (26%), Positives = 294/700 (42%), Gaps = 68/700 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHH----DQQFVIN-PQTGA---ITTNKLLDRETMSGYLLTVTA 553
I S + + H D V QTG +T + +DRE Y ++TA
Sbjct: 431 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 490
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
DG S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G N
Sbjct: 491 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 548
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
G I YE+ +G F+I+ +G+I ++ T+ L A D P + I
Sbjct: 549 GEITYEI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 606
Query: 674 HIKIEDI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGD 730
+ IE + N SPP F + ISE +G + ++A D EG + + Y+I+ GD
Sbjct: 607 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGD 663
Query: 731 DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVN 788
F+L G L LD ES +Y L+I A+ P + V I+VTDVN
Sbjct: 664 PQRVFNLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVN 718
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGS 848
DNAPV + + + G+V A D D Q GN NL + + GS
Sbjct: 719 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGS 777
Query: 849 MTLSPQLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+ + +LN V + V TDG V+ + + L+++++
Sbjct: 778 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL356114-4|CAM15117.1| 1684|Homo sapiens protocadherin 15 protein.
Length = 1684
Score = 267 bits (654), Expect = 4e-70
Identities = 257/843 (30%), Positives = 388/843 (46%), Gaps = 103/843 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDAD-EGVNAELTYTMTDK------DYTGNVDLPITIDPRSGWVYTSGQ 323
+R+ A D D E V T + DYT +T + ++
Sbjct: 418 LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQP 475
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
+DRE Q Y +TA DG S F Y+V + D PG
Sbjct: 476 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 533
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
V+ LTA DADE + + YEI G +G F I GLIT+A ++ R Y LTV
Sbjct: 534 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTV 590
Query: 442 SATDSG----GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDS 496
A D+ R+ V I + NN +P F Y+ + E +G +L + ATD
Sbjct: 591 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 650
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
+ ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG
Sbjct: 651 E---GDSITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG 700
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
P + T V I V DVNDN PVF L + + V QV ATD D G+NG++
Sbjct: 701 R-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 759
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
HY L F I ++G I T L+RE ++L VA DG P+ ST+ + IK
Sbjct: 760 HYSL---GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 677 IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
+ DI+D+ PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+
Sbjct: 816 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 873
Query: 737 LETRQGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDN 790
L G EL + LDYE+ P ++ + + ++ + V ++V D+ND
Sbjct: 874 LHPFTG----ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 929
Query: 791 APV 793
PV
Sbjct: 930 PPV 932
Score = 230 bits (563), Expect = 5e-59
Identities = 237/856 (27%), Positives = 380/856 (44%), Gaps = 81/856 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E +
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-DVPPSGV 441
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
T +PE VF + G + L +DRE+ YT + A D
Sbjct: 442 PTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 496
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 497 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 549
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 550 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 608
Query: 244 LINIRDVNDNA-PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ + PRF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 609 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 661
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+D G P ++TAT
Sbjct: 662 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 720
Query: 363 XXXFMPG-QYEVELAEDEPPG-TPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR 420
F P + + E+E V T DA + ++HY + GN F ITS
Sbjct: 721 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---N 775
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 776 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 835
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 836 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 886
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P V + V D+ND PVF +++Y +
Sbjct: 887 LDYEAFPDQEASITFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 944
Query: 593 DALVGTSVSQVGATDAD-VGL-NGRIHYELDPKD--REEGSFVIDPASGVIRTNKALDRE 648
DA+ GT ++ V A DAD GL R+ Y +D F ++ SG + T L+ E
Sbjct: 945 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1004
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
L VA D G P SS+ V I + + P + + +SE + GT +G
Sbjct: 1005 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1064
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I A N + YSI G++ ++F + G + LDYE+ R Y L ++
Sbjct: 1065 ISA----AAINQSIVYSIVSGNEEDTFGINNITG----VIYVNGPLDYET-RTSYVLRVQ 1115
Query: 769 AAS----------PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA 818
A S P N +V I + D N++ PV + I +D RV A
Sbjct: 1116 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1175
Query: 819 YDADVTD--KLQYRIL 832
D D + + YR++
Sbjct: 1176 TDKDTGNYSVMAYRLI 1191
Score = 200 bits (488), Expect = 6e-50
Identities = 209/786 (26%), Positives = 340/786 (43%), Gaps = 95/786 (12%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD-----------EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
A D D +D LH + + F++T +T+ QP+D ++++ Y
Sbjct: 427 VALDKDIEDVPPSGVPTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTY 484
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
+++A D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D
Sbjct: 485 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 544
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G N +ITY E + F+IN TG IT ++ Y LTV A D
Sbjct: 545 EGSNGEITY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 596
Query: 558 VPS--LSDTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
P+ + V I V+ N+ P F Q +Y+ I E VG + + ATD +
Sbjct: 597 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 653
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
I Y ++ D + F + +G++ KALDRES + L A D G P +ST V+
Sbjct: 654 SITYAIENGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 711
Query: 675 IKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS 734
I + D+ND+ PVF+ +G+++A DPD G N VHYS+ G+ +N
Sbjct: 712 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 769
Query: 735 FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNA 791
F + T GS + T V L+ E R YELV+ A A P + + + I V D++DN+
Sbjct: 770 FRI-TSNGS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 823
Query: 792 PVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
PV + ++ P G ++ A D D+ + YRI S + L+ TG ++
Sbjct: 824 PVFTNSTYTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 882
Query: 851 LSPQLN 856
L L+
Sbjct: 883 LLRSLD 888
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 610 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 660
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 661 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 704
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 705 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 760
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 761 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 818 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 871
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 872 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 929
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 930 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 990 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1047 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1095
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1096 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1155
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1156 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1213
Score = 156 bits (379), Expect = 9e-37
Identities = 184/700 (26%), Positives = 294/700 (42%), Gaps = 68/700 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHH----DQQFVIN-PQTGA---ITTNKLLDRETMSGYLLTVTA 553
I S + + H D V QTG +T + +DRE Y ++TA
Sbjct: 431 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 490
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
DG S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G N
Sbjct: 491 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 548
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
G I YE+ +G F+I+ +G+I ++ T+ L A D P + I
Sbjct: 549 GEITYEI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 606
Query: 674 HIKIEDI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGD 730
+ IE + N SPP F + ISE +G + ++A D EG + + Y+I+ GD
Sbjct: 607 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGD 663
Query: 731 DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVN 788
F+L G L LD ES +Y L+I A+ P + V I+VTDVN
Sbjct: 664 PQRVFNLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVN 718
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGS 848
DNAPV + + + G+V A D D Q GN NL + + GS
Sbjct: 719 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGS 777
Query: 849 MTLSPQLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+ + +LN V + V TDG V+ + + L+++++
Sbjct: 778 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL353784-7|CAM16789.1| 1785|Homo sapiens protocadherin 15 protein.
Length = 1785
Score = 267 bits (654), Expect = 4e-70
Identities = 257/843 (30%), Positives = 388/843 (46%), Gaps = 103/843 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDAD-EGVNAELTYTMTDK------DYTGNVDLPITIDPRSGWVYTSGQ 323
+R+ A D D E V T + DYT +T + ++
Sbjct: 418 LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQP 475
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
+DRE Q Y +TA DG S F Y+V + D PG
Sbjct: 476 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 533
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
V+ LTA DADE + + YEI G +G F I GLIT+A ++ R Y LTV
Sbjct: 534 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTV 590
Query: 442 SATDSG----GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDS 496
A D+ R+ V I + NN +P F Y+ + E +G +L + ATD
Sbjct: 591 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 650
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
+ ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG
Sbjct: 651 E---GDSITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG 700
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
P + T V I V DVNDN PVF L + + V QV ATD D G+NG++
Sbjct: 701 R-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 759
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
HY L F I ++G I T L+RE ++L VA DG P+ ST+ + IK
Sbjct: 760 HYSL---GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 677 IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
+ DI+D+ PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+
Sbjct: 816 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 873
Query: 737 LETRQGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDN 790
L G EL + LDYE+ P ++ + + ++ + V ++V D+ND
Sbjct: 874 LHPFTG----ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 929
Query: 791 APV 793
PV
Sbjct: 930 PPV 932
Score = 230 bits (563), Expect = 5e-59
Identities = 237/856 (27%), Positives = 380/856 (44%), Gaps = 81/856 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E +
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-DVPPSGV 441
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
T +PE VF + G + L +DRE+ YT + A D
Sbjct: 442 PTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 496
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 497 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 549
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 550 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 608
Query: 244 LINIRDVNDNA-PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ + PRF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 609 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 661
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+D G P ++TAT
Sbjct: 662 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 720
Query: 363 XXXFMPG-QYEVELAEDEPPG-TPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR 420
F P + + E+E V T DA + ++HY + GN F ITS
Sbjct: 721 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---N 775
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 776 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 835
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 836 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 886
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P V + V D+ND PVF +++Y +
Sbjct: 887 LDYEAFPDQEASITFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 944
Query: 593 DALVGTSVSQVGATDAD-VGL-NGRIHYELDPKD--REEGSFVIDPASGVIRTNKALDRE 648
DA+ GT ++ V A DAD GL R+ Y +D F ++ SG + T L+ E
Sbjct: 945 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1004
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
L VA D G P SS+ V I + + P + + +SE + GT +G
Sbjct: 1005 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1064
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I A N + YSI G++ ++F + G + LDYE+ R Y L ++
Sbjct: 1065 ISA----AAINQSIVYSIVSGNEEDTFGINNITG----VIYVNGPLDYET-RTSYVLRVQ 1115
Query: 769 AAS----------PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA 818
A S P N +V I + D N++ PV + I +D RV A
Sbjct: 1116 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1175
Query: 819 YDADVTD--KLQYRIL 832
D D + + YR++
Sbjct: 1176 TDKDTGNYSVMAYRLI 1191
Score = 200 bits (488), Expect = 6e-50
Identities = 209/786 (26%), Positives = 340/786 (43%), Gaps = 95/786 (12%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD-----------EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
A D D +D LH + + F++T +T+ QP+D ++++ Y
Sbjct: 427 VALDKDIEDVPPSGVPTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTY 484
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
+++A D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D
Sbjct: 485 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 544
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G N +ITY E + F+IN TG IT ++ Y LTV A D
Sbjct: 545 EGSNGEITY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 596
Query: 558 VPS--LSDTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
P+ + V I V+ N+ P F Q +Y+ I E VG + + ATD +
Sbjct: 597 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 653
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
I Y ++ D + F + +G++ KALDRES + L A D G P +ST V+
Sbjct: 654 SITYAIENGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 711
Query: 675 IKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS 734
I + D+ND+ PVF+ +G+++A DPD G N VHYS+ G+ +N
Sbjct: 712 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 769
Query: 735 FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNA 791
F + T GS + T V L+ E R YELV+ A A P + + + I V D++DN+
Sbjct: 770 FRI-TSNGS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 823
Query: 792 PVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
PV + ++ P G ++ A D D+ + YRI S + L+ TG ++
Sbjct: 824 PVFTNSTYTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 882
Query: 851 LSPQLN 856
L L+
Sbjct: 883 LLRSLD 888
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 610 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 660
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 661 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 704
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 705 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 760
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 761 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 818 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 871
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 872 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 929
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 930 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 990 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1047 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1095
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1096 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1155
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1156 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1213
Score = 156 bits (379), Expect = 9e-37
Identities = 184/700 (26%), Positives = 294/700 (42%), Gaps = 68/700 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHH----DQQFVIN-PQTGA---ITTNKLLDRETMSGYLLTVTA 553
I S + + H D V QTG +T + +DRE Y ++TA
Sbjct: 431 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 490
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
DG S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G N
Sbjct: 491 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 548
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
G I YE+ +G F+I+ +G+I ++ T+ L A D P + I
Sbjct: 549 GEITYEI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 606
Query: 674 HIKIEDI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGD 730
+ IE + N SPP F + ISE +G + ++A D EG + + Y+I+ GD
Sbjct: 607 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGD 663
Query: 731 DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVN 788
F+L G L LD ES +Y L+I A+ P + V I+VTDVN
Sbjct: 664 PQRVFNLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVN 718
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGS 848
DNAPV + + + G+V A D D Q GN NL + + GS
Sbjct: 719 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGS 777
Query: 849 MTLSPQLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+ + +LN V + V TDG V+ + + L+++++
Sbjct: 778 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>AL353784-3|CAM16785.1| 1684|Homo sapiens protocadherin 15 protein.
Length = 1684
Score = 267 bits (654), Expect = 4e-70
Identities = 257/843 (30%), Positives = 388/843 (46%), Gaps = 103/843 (12%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLT-----LKATDQDIGKNAEVEYTIEL 64
+I V D ND+SP F+ + Y A+V E GTT+ T ATD D G N ++EY I+
Sbjct: 134 RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQY 193
Query: 65 VTADTLNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQA 123
NP+D D F I +G ++ R L+ E RY V+++A D+A
Sbjct: 194 ------NPDDPTS---------NDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRA 238
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQF------------SEKTYTVSVDEDISVTD-NPV 170
+++R ++T T+ V+++D +D P F TY ++ E + + NP+
Sbjct: 239 QNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
Query: 171 IA--KIKATDAD-----VGANSAIRYAIIGGNTQ---MQFSIDSLSGDVSLVKTLDYEQV 220
I I+A D D I Y+I+ G + F + + ++SL++ ++ +
Sbjct: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 358
Query: 221 RSYRLVIRA-QDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSI--- 276
+ + LVI+A QD G P + L I I D N+ +P F +Q + E+ P+G +I
Sbjct: 359 QKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS 417
Query: 277 ------VRVQAYDAD-EGVNAELTYTMTDK------DYTGNVDLPITIDPRSGWVYTSGQ 323
+R+ A D D E V T + DYT +T + ++
Sbjct: 418 LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTS--VFTVTQTGITRYLTLLQP 475
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
+DRE Q Y +TA DG S F Y+V + D PG
Sbjct: 476 VDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 533
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
V+ LTA DADE + + YEI G +G F I GLIT+A ++ R Y LTV
Sbjct: 534 SVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GLITIAPGVEMIVGRTYALTV 590
Query: 442 SATDSG----GRSDTAMVQINITDANNYAPV-FENAPYTASVFEDAPIGTTVLVVSATDS 496
A D+ R+ V I + NN +P F Y+ + E +G +L + ATD
Sbjct: 591 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 650
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
+ ITY++ + + F ++ TG +T K LDRE+ Y+L +TA DG
Sbjct: 651 E---GDSITYAIEN-------GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG 700
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRI 616
P + T V I V DVNDN PVF L + + V QV ATD D G+NG++
Sbjct: 701 R-PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 759
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
HY L F I ++G I T L+RE ++L VA DG P+ ST+ + IK
Sbjct: 760 HYSL---GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 677 IEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
+ DI+D+ PVF + T + EN P GTTI +I A D D G N V Y I+ + + F+
Sbjct: 816 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 873
Query: 737 LETRQGSDKAELVTMVDLDYES-PRKKYELVIRAASPPLWNDV-----RVEILVTDVNDN 790
L G EL + LDYE+ P ++ + + ++ + V ++V D+ND
Sbjct: 874 LHPFTG----ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 929
Query: 791 APV 793
PV
Sbjct: 930 PPV 932
Score = 230 bits (563), Expect = 5e-59
Identities = 237/856 (27%), Positives = 380/856 (44%), Gaps = 81/856 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTV---LTLKATDQDIGKNAEVEYTIELVTA 67
I +LD N+ SP F M Y+ + E A G T+ L L + + + + ++E +
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE-DVPPSGV 441
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRID--GRSGALLTRASLDREKVARYTVLVKATDQASP 125
T +PE VF + G + L +DRE+ YT + A D
Sbjct: 442 PTKDPE-----LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 496
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S +++ ++D NDN P F E +Y V V D+ D+ + ++ A DAD G+N
Sbjct: 497 -----SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS--VIQLTAVDADEGSNG 549
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPS--RSNTTQL 243
I Y I+ G Q F I+ +G +++ ++ R+Y L ++A D P+ R++ +
Sbjct: 550 EITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 608
Query: 244 LINIRDVNDNA-PRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
I + N+ + PRF ++ +SE + +G ++ +QA D + +TY + +
Sbjct: 609 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN---- 661
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
G+ + +G + LDRE+ +Y L++TA+D G P ++TAT
Sbjct: 662 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 720
Query: 363 XXXFMPG-QYEVELAEDEPPG-TPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR 420
F P + + E+E V T DA + ++HY + GN F ITS
Sbjct: 721 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---N 775
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASV 478
G I A L+ + Y L V ATD R T + I + D ++ +PVF N+ YT V
Sbjct: 776 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 835
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GTT+L + A D D+G N +S I + V H F ++P TG ++ +
Sbjct: 836 EENLPAGTTILQIEAKDVDLGAN------VSYRIRSPEVKHF---FALHPFTGELSLLRS 886
Query: 539 LDRETMSGYLLTVT----ARD--GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
LD E ++T A D G +P V + V D+ND PVF +++Y +
Sbjct: 887 LDYEAFPDQEASITFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 944
Query: 593 DALVGTSVSQVGATDAD-VGL-NGRIHYELDPKD--REEGSFVIDPASGVIRTNKALDRE 648
DA+ GT ++ V A DAD GL R+ Y +D F ++ SG + T L+ E
Sbjct: 945 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 1004
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
L VA D G P SS+ V I + + P + + +SE + GT +G
Sbjct: 1005 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1064
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR 768
I A N + YSI G++ ++F + G + LDYE+ R Y L ++
Sbjct: 1065 ISA----AAINQSIVYSIVSGNEEDTFGINNITG----VIYVNGPLDYET-RTSYVLRVQ 1115
Query: 769 AAS----------PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA 818
A S P N +V I + D N++ PV + I +D RV A
Sbjct: 1116 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1175
Query: 819 YDADVTD--KLQYRIL 832
D D + + YR++
Sbjct: 1176 TDKDTGNYSVMAYRLI 1191
Score = 200 bits (488), Expect = 6e-50
Identities = 209/786 (26%), Positives = 340/786 (43%), Gaps = 95/786 (12%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIK----ATDADVGANSAIRYAI 191
+ + + D NDN P F ++Y +V+E ++ + ATD D G N I Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-V 190
Query: 192 IGGNTQMQFSIDS------LSGDVSLVKTLDYEQVRSYRLVIRAQDGG---SPSRSNTTQ 242
I N S D+ L+G++ L K L+YE Y ++I+A D + R+ TT
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYS---------------IVR--VQAYDAD 285
L +++ D +D P F + + + P+ Y IV +QA D D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 286 EGVNAE-----LTYTM---TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVT 337
+ + Y++ T +DY + PR+ + ++R+ K+ L++
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHM----HPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 338 ATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV---------VTL 388
A P A A F Y+ + E P G + + +
Sbjct: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRI 426
Query: 389 TATDAD-----------EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
A D D +D LH + + F++T +T+ QP+D ++++ Y
Sbjct: 427 VALDKDIEDVPPSGVPTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTY 484
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
+++A D S+ +V I + DAN+ P F Y V+ D G +V+ ++A D+D
Sbjct: 485 TFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 544
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G N +ITY E + F+IN TG IT ++ Y LTV A D
Sbjct: 545 EGSNGEITY--------EILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 596
Query: 558 VPS--LSDTTDVEISVVDVNDNEPV-FKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
P+ + V I V+ N+ P F Q +Y+ I E VG + + ATD +
Sbjct: 597 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 653
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
I Y ++ D + F + +G++ KALDRES + L A D G P +ST V+
Sbjct: 654 SITYAIENGDPQR-VFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 711
Query: 675 IKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNS 734
I + D+ND+ PVF+ +G+++A DPD G N VHYS+ G+ +N
Sbjct: 712 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNL 769
Query: 735 FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNA 791
F + T GS + T V L+ E R YELV+ A A P + + + I V D++DN+
Sbjct: 770 FRI-TSNGS----IYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 823
Query: 792 PVMKDFQIIFNNYKDCFPVG-PFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGSMT 850
PV + ++ P G ++ A D D+ + YRI S + L+ TG ++
Sbjct: 824 PVFTNSTYTV-LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELS 882
Query: 851 LSPQLN 856
L L+
Sbjct: 883 LLRSLD 888
Score = 194 bits (474), Expect = 3e-48
Identities = 205/658 (31%), Positives = 297/658 (45%), Gaps = 81/658 (12%)
Query: 11 INVLDCNDHSPV-FEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
I VL N+ SP F Y + E G +L L+ATD++ + Y IE
Sbjct: 610 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE------ 660
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N + Q VF + +G L +LDRE RY +++ A+D P
Sbjct: 661 -NGDP------------QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG-- 704
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKT-YTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+STAT+++ + D NDN P F +SV E+ + N + ++KATD D G N +
Sbjct: 705 -TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVH 760
Query: 189 YAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
Y++ GN F I S +G + L+ E Y LV+ A DG R +T L I +
Sbjct: 761 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
D++DN+P F S + V EN+P G +I++++A D D G N ++Y + + V
Sbjct: 818 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE----VKHF 871
Query: 309 ITIDPRSGWVYTSGQLDRET----QAKYQLLVTATD--GGDPPRSATATXXXXXXXXXXX 362
+ P +G + LD E +A LV A D G PP AT T
Sbjct: 872 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT--VIVKDMNDY 929
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADED----NRLHYEITGGN---TRGRFSIT 415
F Y+ +A D GTP+ T+ A DAD +R+ Y + F +
Sbjct: 930 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAP 473
+GR + V L+ + + L V A D G S +A V+I + P F
Sbjct: 990 EDSGRVITRV--NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Query: 474 Y-TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
Y V E A GT V V+SA IN I YS+ S NE + F IN TG
Sbjct: 1047 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS--GNE-----EDTFGINNITGV 1095
Query: 533 ITTNKLLDRETMSGYLLTVTA-------RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
I N LD ET + Y+L V A + VPS S+T V I + D N++ PVF+++
Sbjct: 1096 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1155
Query: 586 YTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEG--SFVIDPASGVIRT 641
Y + EDA + TSV +V ATD D G + Y L +EG FV++ +G+I+T
Sbjct: 1156 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1213
Score = 156 bits (379), Expect = 9e-37
Identities = 184/700 (26%), Positives = 294/700 (42%), Gaps = 68/700 (9%)
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVR-----VQAYDADEGVNAELTYTM 296
++ I +RD NDN+P F + +V+E P+G +I A D D+G N ++ Y +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 297 --TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGG---DPPRSATAT 351
D T N I + +G + +L+ E + +Y +++ A D + R+ T T
Sbjct: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 352 XXXXXXXXXXXXXXFMPG------------QYEVELAEDEPPG--TPVVTLTATDA-DED 396
F+P Y+ + E P P++ A D+D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 397 NRLH---------YEITGGNTRGRFSITSQNGR-GLITVAQPLDFKQERRYVLTVSATDS 446
+ Y I G + R +++ +P++ +++ L + A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
Query: 447 GGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTV---LVVSATDSDVGIN 501
G A + I I D NN +P F Y + E AP+G T+ L +++ V ++
Sbjct: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
Query: 502 AQITYSLSSEISNEAVAHH----DQQFVIN-PQTGA---ITTNKLLDRETMSGYLLTVTA 553
I S + + H D V QTG +T + +DRE Y ++TA
Sbjct: 431 KDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 490
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
DG S+ V I V+D NDN P F + Y + D G SV Q+ A DAD G N
Sbjct: 491 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 548
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
G I YE+ +G F+I+ +G+I ++ T+ L A D P + I
Sbjct: 549 GEITYEI--LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 606
Query: 674 HIKIEDI---NDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGD 730
+ IE + N SPP F + ISE +G + ++A D EG + + Y+I+ GD
Sbjct: 607 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDS--ITYAIENGD 663
Query: 731 DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWNDVRVEILVTDVN 788
F+L G L LD ES +Y L+I A+ P + V I+VTDVN
Sbjct: 664 PQRVFNLSETTGI----LTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVN 718
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNETTGS 848
DNAPV + + + G+V A D D Q GN NL + + GS
Sbjct: 719 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGS 777
Query: 849 MTLSPQLNTNVPKLATMEVSVTDG-VNEIKAMMQLSVRLI 887
+ + +LN V + V TDG V+ + + L+++++
Sbjct: 778 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 817
Score = 49.2 bits (112), Expect = 2e-04
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 19/216 (8%)
Query: 619 ELDPKDREEGSFVIDPASGVI---RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH- 674
EL KD + ++DP ++ T + LDR+ V + + T+I H
Sbjct: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC-INKKVGTIIYHE 132
Query: 675 --IKIEDINDSPPVFESDCLTFYISENSPIGTTI-----GEIRAHDPDEGPNAVVHYSIK 727
I + D ND+ P F+ + ++E +P+GTTI G+ A D D+GPN + Y I+
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 728 -GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVR--VEIL 783
DD S +V L+YE + +Y ++I+A N+ R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYED-KTRYFVIIQANDRAQNLNERRTTTTTL 251
Query: 784 VTDVNDNAPVMKDFQ--IIFNNYKDCFPVGPFGRVP 817
DV D + F ++ N +DC P+ +P
Sbjct: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 287
>BC103927-1|AAI03928.1| 810|Homo sapiens protocadherin gamma
subfamily B, 1 protein.
Length = 810
Score = 262 bits (642), Expect = 1e-68
Identities = 195/614 (31%), Positives = 294/614 (47%), Gaps = 41/614 (6%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D F + SG LL +DREK+ + + + V++ + + V I D NDN
Sbjct: 69 EDYFNVSLESGDLLVNGRIDREKICGRKL--ECALEFETVAENPMNVFHVVVVIQDINDN 126
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSL- 205
P+F K + + E S + A DADV NS Y I N FS+ +
Sbjct: 127 APRFVAKGIDLEICE--SALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLSTKE 181
Query: 206 SGDVS------LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
S D S L K LD E S+RL++ A DGG P S TT + I + D NDNAP F
Sbjct: 182 SPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ 241
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+++ S+ ENVP G S++RV A D DEG+NAE+TY + + ++ ++P +G +
Sbjct: 242 EVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL---FNLNPNTGDIT 298
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
T+G LD E ++Y L V A DGG FM + ++ ED
Sbjct: 299 TNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFM--SFSNQIPEDS 356
Query: 380 PPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYV 438
GT + + D D N + T + TS+N L+ +A L+ +Q Y
Sbjct: 357 DLGTVIALIKVRDKDSGQNGMVTCYTQEEVPFKLESTSKNYYKLV-IAGALNREQTADYN 415
Query: 439 LTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
+T+ ATD G S + ++I+D N+ APVF A Y V E+ P G ++ VSA+D
Sbjct: 416 VTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDP 475
Query: 497 DVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
D+G N +++YS L+S++ + + ++PQ+G + + D E + + LT+ ARD
Sbjct: 476 DLGPNGRVSYSILASDLEPRELLSY---VSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGA 605
G P+LS + + V D+NDN P + LY A + A G V++V A
Sbjct: 533 QGSPALSANVSLRVLVGDLNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVA 589
Query: 606 TDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G N + Y + + E G F + +G +RT +AL A L DGG P
Sbjct: 590 VDADSGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQP 648
Query: 666 PQSSTVIVHIKIED 679
P S+T +H+ D
Sbjct: 649 PLSATATLHLIFAD 662
Score = 243 bits (594), Expect = 8e-63
Identities = 180/606 (29%), Positives = 284/606 (46%), Gaps = 34/606 (5%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAPRFY 258
F++ SGD+ + +D E++ +L + + + + N +++ I+D+NDNAPRF
Sbjct: 72 FNVSLESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFV 131
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
+ E+ G A DAD N+ YT+ Y + +
Sbjct: 132 AKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVL 191
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
LDRE Q+ ++L++TA DGGDPP S T F Y V L E+
Sbjct: 192 LLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQEN 251
Query: 379 EPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN---GRGLITVAQPLDFKQER 435
P GT V+ + ATD DE ++ EIT S + N G IT LDF++
Sbjct: 252 VPWGTSVLRVMATDQDEG--INAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETS 309
Query: 436 RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
RYVL+V A D G + VQI I D N+ AP ++ + ED+ +GT + ++ D
Sbjct: 310 RYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRD 369
Query: 496 SDVGINAQITYSLSSEI--SNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D G N +T E+ E+ + + + VI GA L+RE + Y +T+ A
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVI---AGA------LNREQTADYNVTIIA 420
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D G P+LS T + + + D+NDN PVF Q Y ++ E+ G S++QV A+D D+G N
Sbjct: 421 TDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPN 480
Query: 614 GRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GR+ Y + D + RE S+V + P SGV+ +A D E + +L A D G+P S+
Sbjct: 481 GRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSA 540
Query: 670 TVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
V + + + D+ND+ P + L + + G + ++ A D D G NA +
Sbjct: 541 NVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWL 600
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLWNDVRV 780
Y + + FSL R G E+ T L D ++ R++ + +R PPL +
Sbjct: 601 SYHVLQASEPGLFSLGLRTG----EVRTARALGDRDAARQRLLVAVRDGGQPPLSATATL 656
Query: 781 EILVTD 786
++ D
Sbjct: 657 HLIFAD 662
Score = 223 bits (545), Expect = 7e-57
Identities = 179/530 (33%), Positives = 259/530 (48%), Gaps = 37/530 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRLH-YEITGGNTRGRFSITSQNGRG-- 421
F+ ++E+ E PG +A DAD E N L Y I + S +G
Sbjct: 130 FVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYP 189
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
++ + +PLD + + + L ++A D G S T + I +TDAN+ APVF Y S+
Sbjct: 190 VLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GT+VL V ATD D GINA+ITY+ L+S IS F +NP TG ITTN
Sbjct: 250 ENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL-------FNLNPNTGDITTNGT 302
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LD E S Y+L+V A+DGGV + +V+I +VD NDN P ++ I ED+ +GT
Sbjct: 303 LDFEETSRYVLSVEAKDGGVHTAH--CNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGT 360
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDL 655
++ + D D G NG + +EE F ++ S + AL+RE A +++
Sbjct: 361 VIALIKVRDKDSGQNGMVTCYT----QEEVPFKLESTSKNYYKLVIAGALNREQTADYNV 416
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+A D G P SS + + I DIND+ PVF ++SEN+P G +I ++ A DPD
Sbjct: 417 TIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPD 476
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV-TMVDLDYESPRKKYELVIRA---AS 771
GPN V YSI D L S ++ +V D+E R +EL ++A S
Sbjct: 477 LGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRA-FELTLQARDQGS 535
Query: 772 PPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPF-GRVPAYDADVT 824
P L +V + +LV D+NDNAP + D +F+ G +V A DAD
Sbjct: 536 PALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSG 595
Query: 825 DK--LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 596 HNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 645
Score = 168 bits (409), Expect = 2e-40
Identities = 135/474 (28%), Positives = 218/474 (45%), Gaps = 43/474 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H I V D ND++PVF + Y S++E GT+VL + ATDQD G NAE+ Y
Sbjct: 224 HIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAF----- 278
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
LN + +F ++ +G + T +LD E+ +RY + V+A D
Sbjct: 279 --LNSPIST-----------SLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVH-- 323
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
++ + + I+D+NDN P+ + +++ + ED + VIA IK D D G N +
Sbjct: 324 ---TAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDL--GTVIALIKVRDKDSGQNGMV 378
Query: 188 RYAIIGGNTQMQFSIDSLSGD---VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
++ F ++S S + + + L+ EQ Y + I A D G P+ S+ T +
Sbjct: 379 TCYT---QEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSIT 435
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
++I D+NDNAP F+ + + VSEN P G SI +V A D D G N ++Y++ D
Sbjct: 436 LHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPR 495
Query: 305 VDLP-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
L +++ P+SG V+ D E ++L + A D G P SA +
Sbjct: 496 ELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNA 555
Query: 364 XXFM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSI 414
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 616 GLRTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEV 667
Score = 155 bits (375), Expect = 3e-36
Identities = 142/484 (29%), Positives = 219/484 (45%), Gaps = 21/484 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + I D N+ AP F + E A G + SA D+DV N+ Y+++ N
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINP---N 172
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ + ++ + + K LDRE S + L +TA DGG P LS TT + I V D
Sbjct: 173 QYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDA 232
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN PVF Q++Y ++ E+ GTSV +V ATD D G+N I Y F ++P
Sbjct: 233 NDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSLFNLNP 292
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I TN LD E + + L A DGG ++ V I+I D ND+ P +
Sbjct: 293 NTGDITTNGTLDFEETSRYVLSVEAKDGGV--HTAHCNVQIEIVDENDNAPEVTFMSFSN 350
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I E+S +GT I I+ D D G N +V + + F LE+ + +LV L
Sbjct: 351 QIPEDSDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLES-TSKNYYKLVIAGAL 406
Query: 755 DYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
+ E Y + I A P L + + + ++D+NDNAPV + + ++ P
Sbjct: 407 NREQ-TADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGA 465
Query: 812 PFGRVPAYDADV--TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
+V A D D+ ++ Y IL+ + + E +++SPQ + A +
Sbjct: 466 SIAQVSASDPDLGPNGRVSYSILASD----LEPRELLSYVSVSPQSGVVFAQRAFDHEQL 521
Query: 870 TDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKE 929
++A Q S L + + L + LND A + L P LG L ++P E
Sbjct: 522 RAFELTLQARDQGSPAL-SANVSLRVLVGDLND-NAPRVLYPALGPDGSALFDMVPRAAE 579
Query: 930 NIYI 933
Y+
Sbjct: 580 PGYL 583
>BC103926-1|AAI03927.1| 810|Homo sapiens protocadherin gamma
subfamily B, 1 protein.
Length = 810
Score = 262 bits (642), Expect = 1e-68
Identities = 195/614 (31%), Positives = 294/614 (47%), Gaps = 41/614 (6%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D F + SG LL +DREK+ + + + V++ + + V I D NDN
Sbjct: 69 EDYFNVSLESGDLLVNGRIDREKICGRKL--ECALEFETVAENPMNVFHVVVVIQDINDN 126
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSL- 205
P+F K + + E S + A DADV NS Y I N FS+ +
Sbjct: 127 APRFVAKGIDLEICE--SALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLSTKE 181
Query: 206 SGDVS------LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
S D S L K LD E S+RL++ A DGG P S TT + I + D NDNAP F
Sbjct: 182 SPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ 241
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+++ S+ ENVP G S++RV A D DEG+NAE+TY + + ++ ++P +G +
Sbjct: 242 EVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL---FNLNPNTGDIT 298
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
T+G LD E ++Y L V A DGG FM + ++ ED
Sbjct: 299 TNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFM--SFSNQIPEDS 356
Query: 380 PPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYV 438
GT + + D D N + T + TS+N L+ +A L+ +Q Y
Sbjct: 357 DLGTVIALIKVRDKDSGQNGMVTCYTQEEVPFKLESTSKNYYKLV-IAGALNREQTADYN 415
Query: 439 LTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
+T+ ATD G S + ++I+D N+ APVF A Y V E+ P G ++ VSA+D
Sbjct: 416 VTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDP 475
Query: 497 DVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
D+G N +++YS L+S++ + + ++PQ+G + + D E + + LT+ ARD
Sbjct: 476 DLGPNGRVSYSILASDLEPRELLSY---VSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGA 605
G P+LS + + V D+NDN P + LY A + A G V++V A
Sbjct: 533 QGSPALSANVSLRVLVGDLNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVA 589
Query: 606 TDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G N + Y + + E G F + +G +RT +AL A L DGG P
Sbjct: 590 VDADSGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQP 648
Query: 666 PQSSTVIVHIKIED 679
P S+T +H+ D
Sbjct: 649 PLSATATLHLIFAD 662
Score = 243 bits (594), Expect = 8e-63
Identities = 180/606 (29%), Positives = 284/606 (46%), Gaps = 34/606 (5%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAPRFY 258
F++ SGD+ + +D E++ +L + + + + N +++ I+D+NDNAPRF
Sbjct: 72 FNVSLESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFV 131
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
+ E+ G A DAD N+ YT+ Y + +
Sbjct: 132 AKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVL 191
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
LDRE Q+ ++L++TA DGGDPP S T F Y V L E+
Sbjct: 192 LLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQEN 251
Query: 379 EPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN---GRGLITVAQPLDFKQER 435
P GT V+ + ATD DE ++ EIT S + N G IT LDF++
Sbjct: 252 VPWGTSVLRVMATDQDEG--INAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETS 309
Query: 436 RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
RYVL+V A D G + VQI I D N+ AP ++ + ED+ +GT + ++ D
Sbjct: 310 RYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRD 369
Query: 496 SDVGINAQITYSLSSEI--SNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D G N +T E+ E+ + + + VI GA L+RE + Y +T+ A
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVI---AGA------LNREQTADYNVTIIA 420
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D G P+LS T + + + D+NDN PVF Q Y ++ E+ G S++QV A+D D+G N
Sbjct: 421 TDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPN 480
Query: 614 GRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GR+ Y + D + RE S+V + P SGV+ +A D E + +L A D G+P S+
Sbjct: 481 GRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSA 540
Query: 670 TVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
V + + + D+ND+ P + L + + G + ++ A D D G NA +
Sbjct: 541 NVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWL 600
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLWNDVRV 780
Y + + FSL R G E+ T L D ++ R++ + +R PPL +
Sbjct: 601 SYHVLQASEPGLFSLGLRTG----EVRTARALGDRDAARQRLLVAVRDGGQPPLSATATL 656
Query: 781 EILVTD 786
++ D
Sbjct: 657 HLIFAD 662
Score = 223 bits (545), Expect = 7e-57
Identities = 179/530 (33%), Positives = 259/530 (48%), Gaps = 37/530 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRLH-YEITGGNTRGRFSITSQNGRG-- 421
F+ ++E+ E PG +A DAD E N L Y I + S +G
Sbjct: 130 FVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYP 189
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
++ + +PLD + + + L ++A D G S T + I +TDAN+ APVF Y S+
Sbjct: 190 VLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GT+VL V ATD D GINA+ITY+ L+S IS F +NP TG ITTN
Sbjct: 250 ENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL-------FNLNPNTGDITTNGT 302
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LD E S Y+L+V A+DGGV + +V+I +VD NDN P ++ I ED+ +GT
Sbjct: 303 LDFEETSRYVLSVEAKDGGVHTAH--CNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGT 360
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDL 655
++ + D D G NG + +EE F ++ S + AL+RE A +++
Sbjct: 361 VIALIKVRDKDSGQNGMVTCYT----QEEVPFKLESTSKNYYKLVIAGALNREQTADYNV 416
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+A D G P SS + + I DIND+ PVF ++SEN+P G +I ++ A DPD
Sbjct: 417 TIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPD 476
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV-TMVDLDYESPRKKYELVIRA---AS 771
GPN V YSI D L S ++ +V D+E R +EL ++A S
Sbjct: 477 LGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRA-FELTLQARDQGS 535
Query: 772 PPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPF-GRVPAYDADVT 824
P L +V + +LV D+NDNAP + D +F+ G +V A DAD
Sbjct: 536 PALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSG 595
Query: 825 DK--LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 596 HNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 645
Score = 168 bits (409), Expect = 2e-40
Identities = 135/474 (28%), Positives = 218/474 (45%), Gaps = 43/474 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H I V D ND++PVF + Y S++E GT+VL + ATDQD G NAE+ Y
Sbjct: 224 HIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAF----- 278
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
LN + +F ++ +G + T +LD E+ +RY + V+A D
Sbjct: 279 --LNSPIST-----------SLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVH-- 323
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
++ + + I+D+NDN P+ + +++ + ED + VIA IK D D G N +
Sbjct: 324 ---TAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDL--GTVIALIKVRDKDSGQNGMV 378
Query: 188 RYAIIGGNTQMQFSIDSLSGD---VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
++ F ++S S + + + L+ EQ Y + I A D G P+ S+ T +
Sbjct: 379 TCYT---QEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSIT 435
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
++I D+NDNAP F+ + + VSEN P G SI +V A D D G N ++Y++ D
Sbjct: 436 LHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPR 495
Query: 305 VDLP-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
L +++ P+SG V+ D E ++L + A D G P SA +
Sbjct: 496 ELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNA 555
Query: 364 XXFM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSI 414
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 616 GLRTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEV 667
Score = 155 bits (375), Expect = 3e-36
Identities = 142/484 (29%), Positives = 219/484 (45%), Gaps = 21/484 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + I D N+ AP F + E A G + SA D+DV N+ Y+++ N
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINP---N 172
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ + ++ + + K LDRE S + L +TA DGG P LS TT + I V D
Sbjct: 173 QYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDA 232
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN PVF Q++Y ++ E+ GTSV +V ATD D G+N I Y F ++P
Sbjct: 233 NDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSLFNLNP 292
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I TN LD E + + L A DGG ++ V I+I D ND+ P +
Sbjct: 293 NTGDITTNGTLDFEETSRYVLSVEAKDGGV--HTAHCNVQIEIVDENDNAPEVTFMSFSN 350
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I E+S +GT I I+ D D G N +V + + F LE+ + +LV L
Sbjct: 351 QIPEDSDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLES-TSKNYYKLVIAGAL 406
Query: 755 DYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
+ E Y + I A P L + + + ++D+NDNAPV + + ++ P
Sbjct: 407 NREQ-TADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGA 465
Query: 812 PFGRVPAYDADV--TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
+V A D D+ ++ Y IL+ + + E +++SPQ + A +
Sbjct: 466 SIAQVSASDPDLGPNGRVSYSILASD----LEPRELLSYVSVSPQSGVVFAQRAFDHEQL 521
Query: 870 TDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKE 929
++A Q S L + + L + LND A + L P LG L ++P E
Sbjct: 522 RAFELTLQARDQGSPAL-SANVSLRVLVGDLND-NAPRVLYPALGPDGSALFDMVPRAAE 579
Query: 930 NIYI 933
Y+
Sbjct: 580 PGYL 583
>AF152517-1|AAD43777.1| 810|Homo sapiens protocadherin gamma B1
short form protein protein.
Length = 810
Score = 262 bits (642), Expect = 1e-68
Identities = 195/614 (31%), Positives = 294/614 (47%), Gaps = 41/614 (6%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D F + SG LL +DREK+ + + + V++ + + V I D NDN
Sbjct: 69 EDYFNVSLESGDLLVNGRIDREKICGRKL--ECALEFETVAENPMNVFHVVVVIQDINDN 126
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSL- 205
P+F K + + E S + A DADV NS Y I N FS+ +
Sbjct: 127 APRFVAKGIDLEICE--SALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLSTKE 181
Query: 206 SGDVS------LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
S D S L K LD E S+RL++ A DGG P S TT + I + D NDNAP F
Sbjct: 182 SPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ 241
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+++ S+ ENVP G S++RV A D DEG+NAE+TY + + ++ ++P +G +
Sbjct: 242 EVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL---FNLNPNTGDIT 298
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
T+G LD E ++Y L V A DGG FM + ++ ED
Sbjct: 299 TNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFM--SFSNQIPEDS 356
Query: 380 PPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYV 438
GT + + D D N + T + TS+N L+ +A L+ +Q Y
Sbjct: 357 DLGTVIALIKVRDKDSGQNGMVTCYTQEEVPFKLESTSKNYYKLV-IAGALNREQTADYN 415
Query: 439 LTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
+T+ ATD G S + ++I+D N+ APVF A Y V E+ P G ++ VSA+D
Sbjct: 416 VTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDP 475
Query: 497 DVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
D+G N +++YS L+S++ + + ++PQ+G + + D E + + LT+ ARD
Sbjct: 476 DLGPNGRVSYSILASDLEPRELLSY---VSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGA 605
G P+LS + + V D+NDN P + LY A + A G V++V A
Sbjct: 533 QGSPALSANVSLRVLVGDLNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVA 589
Query: 606 TDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G N + Y + + E G F + +G +RT +AL A L DGG P
Sbjct: 590 VDADSGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQP 648
Query: 666 PQSSTVIVHIKIED 679
P S+T +H+ D
Sbjct: 649 PLSATATLHLIFAD 662
Score = 243 bits (594), Expect = 8e-63
Identities = 180/606 (29%), Positives = 284/606 (46%), Gaps = 34/606 (5%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAPRFY 258
F++ SGD+ + +D E++ +L + + + + N +++ I+D+NDNAPRF
Sbjct: 72 FNVSLESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFV 131
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
+ E+ G A DAD N+ YT+ Y + +
Sbjct: 132 AKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVL 191
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
LDRE Q+ ++L++TA DGGDPP S T F Y V L E+
Sbjct: 192 LLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQEN 251
Query: 379 EPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN---GRGLITVAQPLDFKQER 435
P GT V+ + ATD DE ++ EIT S + N G IT LDF++
Sbjct: 252 VPWGTSVLRVMATDQDEG--INAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETS 309
Query: 436 RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
RYVL+V A D G + VQI I D N+ AP ++ + ED+ +GT + ++ D
Sbjct: 310 RYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRD 369
Query: 496 SDVGINAQITYSLSSEI--SNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D G N +T E+ E+ + + + VI GA L+RE + Y +T+ A
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVI---AGA------LNREQTADYNVTIIA 420
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D G P+LS T + + + D+NDN PVF Q Y ++ E+ G S++QV A+D D+G N
Sbjct: 421 TDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPN 480
Query: 614 GRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GR+ Y + D + RE S+V + P SGV+ +A D E + +L A D G+P S+
Sbjct: 481 GRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSA 540
Query: 670 TVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
V + + + D+ND+ P + L + + G + ++ A D D G NA +
Sbjct: 541 NVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWL 600
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLWNDVRV 780
Y + + FSL R G E+ T L D ++ R++ + +R PPL +
Sbjct: 601 SYHVLQASEPGLFSLGLRTG----EVRTARALGDRDAARQRLLVAVRDGGQPPLSATATL 656
Query: 781 EILVTD 786
++ D
Sbjct: 657 HLIFAD 662
Score = 223 bits (545), Expect = 7e-57
Identities = 179/530 (33%), Positives = 259/530 (48%), Gaps = 37/530 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRLH-YEITGGNTRGRFSITSQNGRG-- 421
F+ ++E+ E PG +A DAD E N L Y I + S +G
Sbjct: 130 FVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYP 189
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
++ + +PLD + + + L ++A D G S T + I +TDAN+ APVF Y S+
Sbjct: 190 VLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GT+VL V ATD D GINA+ITY+ L+S IS F +NP TG ITTN
Sbjct: 250 ENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL-------FNLNPNTGDITTNGT 302
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LD E S Y+L+V A+DGGV + +V+I +VD NDN P ++ I ED+ +GT
Sbjct: 303 LDFEETSRYVLSVEAKDGGVHTAH--CNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGT 360
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDL 655
++ + D D G NG + +EE F ++ S + AL+RE A +++
Sbjct: 361 VIALIKVRDKDSGQNGMVTCYT----QEEVPFKLESTSKNYYKLVIAGALNREQTADYNV 416
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+A D G P SS + + I DIND+ PVF ++SEN+P G +I ++ A DPD
Sbjct: 417 TIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPD 476
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV-TMVDLDYESPRKKYELVIRA---AS 771
GPN V YSI D L S ++ +V D+E R +EL ++A S
Sbjct: 477 LGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRA-FELTLQARDQGS 535
Query: 772 PPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPF-GRVPAYDADVT 824
P L +V + +LV D+NDNAP + D +F+ G +V A DAD
Sbjct: 536 PALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSG 595
Query: 825 DK--LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 596 HNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 645
Score = 168 bits (409), Expect = 2e-40
Identities = 135/474 (28%), Positives = 218/474 (45%), Gaps = 43/474 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H I V D ND++PVF + Y S++E GT+VL + ATDQD G NAE+ Y
Sbjct: 224 HIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAF----- 278
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
LN + +F ++ +G + T +LD E+ +RY + V+A D
Sbjct: 279 --LNSPIST-----------SLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVH-- 323
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
++ + + I+D+NDN P+ + +++ + ED + VIA IK D D G N +
Sbjct: 324 ---TAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDL--GTVIALIKVRDKDSGQNGMV 378
Query: 188 RYAIIGGNTQMQFSIDSLSGD---VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
++ F ++S S + + + L+ EQ Y + I A D G P+ S+ T +
Sbjct: 379 TCYT---QEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSIT 435
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
++I D+NDNAP F+ + + VSEN P G SI +V A D D G N ++Y++ D
Sbjct: 436 LHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPR 495
Query: 305 VDLP-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
L +++ P+SG V+ D E ++L + A D G P SA +
Sbjct: 496 ELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNA 555
Query: 364 XXFM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSI 414
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 616 GLRTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEV 667
Score = 155 bits (375), Expect = 3e-36
Identities = 142/484 (29%), Positives = 219/484 (45%), Gaps = 21/484 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + I D N+ AP F + E A G + SA D+DV N+ Y+++ N
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINP---N 172
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ + ++ + + K LDRE S + L +TA DGG P LS TT + I V D
Sbjct: 173 QYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDA 232
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN PVF Q++Y ++ E+ GTSV +V ATD D G+N I Y F ++P
Sbjct: 233 NDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSLFNLNP 292
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I TN LD E + + L A DGG ++ V I+I D ND+ P +
Sbjct: 293 NTGDITTNGTLDFEETSRYVLSVEAKDGGV--HTAHCNVQIEIVDENDNAPEVTFMSFSN 350
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I E+S +GT I I+ D D G N +V + + F LE+ + +LV L
Sbjct: 351 QIPEDSDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLES-TSKNYYKLVIAGAL 406
Query: 755 DYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
+ E Y + I A P L + + + ++D+NDNAPV + + ++ P
Sbjct: 407 NREQ-TADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGA 465
Query: 812 PFGRVPAYDADV--TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
+V A D D+ ++ Y IL+ + + E +++SPQ + A +
Sbjct: 466 SIAQVSASDPDLGPNGRVSYSILASD----LEPRELLSYVSVSPQSGVVFAQRAFDHEQL 521
Query: 870 TDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKE 929
++A Q S L + + L + LND A + L P LG L ++P E
Sbjct: 522 RAFELTLQARDQGSPAL-SANVSLRVLVGDLND-NAPRVLYPALGPDGSALFDMVPRAAE 579
Query: 930 NIYI 933
Y+
Sbjct: 580 PGYL 583
>AF152330-1|AAD43724.1| 927|Homo sapiens protocadherin gamma B1
protein.
Length = 927
Score = 262 bits (642), Expect = 1e-68
Identities = 195/614 (31%), Positives = 294/614 (47%), Gaps = 41/614 (6%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D F + SG LL +DREK+ + + + V++ + + V I D NDN
Sbjct: 69 EDYFNVSLESGDLLVNGRIDREKICGRKL--ECALEFETVAENPMNVFHVVVVIQDINDN 126
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSL- 205
P+F K + + E S + A DADV NS Y I N FS+ +
Sbjct: 127 APRFVAKGIDLEICE--SALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLSTKE 181
Query: 206 SGDVS------LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
S D S L K LD E S+RL++ A DGG P S TT + I + D NDNAP F
Sbjct: 182 SPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ 241
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+++ S+ ENVP G S++RV A D DEG+NAE+TY + + ++ ++P +G +
Sbjct: 242 EVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL---FNLNPNTGDIT 298
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
T+G LD E ++Y L V A DGG FM + ++ ED
Sbjct: 299 TNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFM--SFSNQIPEDS 356
Query: 380 PPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYV 438
GT + + D D N + T + TS+N L+ +A L+ +Q Y
Sbjct: 357 DLGTVIALIKVRDKDSGQNGMVTCYTQEEVPFKLESTSKNYYKLV-IAGALNREQTADYN 415
Query: 439 LTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
+T+ ATD G S + ++I+D N+ APVF A Y V E+ P G ++ VSA+D
Sbjct: 416 VTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDP 475
Query: 497 DVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
D+G N +++YS L+S++ + + ++PQ+G + + D E + + LT+ ARD
Sbjct: 476 DLGPNGRVSYSILASDLEPRELLSY---VSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGA 605
G P+LS + + V D+NDN P + LY A + A G V++V A
Sbjct: 533 QGSPALSANVSLRVLVGDLNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVA 589
Query: 606 TDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G N + Y + + E G F + +G +RT +AL A L DGG P
Sbjct: 590 VDADSGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQP 648
Query: 666 PQSSTVIVHIKIED 679
P S+T +H+ D
Sbjct: 649 PLSATATLHLIFAD 662
Score = 243 bits (594), Expect = 8e-63
Identities = 180/606 (29%), Positives = 284/606 (46%), Gaps = 34/606 (5%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAPRFY 258
F++ SGD+ + +D E++ +L + + + + N +++ I+D+NDNAPRF
Sbjct: 72 FNVSLESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFV 131
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
+ E+ G A DAD N+ YT+ Y + +
Sbjct: 132 AKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVL 191
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
LDRE Q+ ++L++TA DGGDPP S T F Y V L E+
Sbjct: 192 LLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQEN 251
Query: 379 EPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN---GRGLITVAQPLDFKQER 435
P GT V+ + ATD DE ++ EIT S + N G IT LDF++
Sbjct: 252 VPWGTSVLRVMATDQDEG--INAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETS 309
Query: 436 RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
RYVL+V A D G + VQI I D N+ AP ++ + ED+ +GT + ++ D
Sbjct: 310 RYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRD 369
Query: 496 SDVGINAQITYSLSSEI--SNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D G N +T E+ E+ + + + VI GA L+RE + Y +T+ A
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVI---AGA------LNREQTADYNVTIIA 420
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D G P+LS T + + + D+NDN PVF Q Y ++ E+ G S++QV A+D D+G N
Sbjct: 421 TDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPN 480
Query: 614 GRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
GR+ Y + D + RE S+V + P SGV+ +A D E + +L A D G+P S+
Sbjct: 481 GRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSA 540
Query: 670 TVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
V + + + D+ND+ P + L + + G + ++ A D D G NA +
Sbjct: 541 NVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWL 600
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLWNDVRV 780
Y + + FSL R G E+ T L D ++ R++ + +R PPL +
Sbjct: 601 SYHVLQASEPGLFSLGLRTG----EVRTARALGDRDAARQRLLVAVRDGGQPPLSATATL 656
Query: 781 EILVTD 786
++ D
Sbjct: 657 HLIFAD 662
Score = 223 bits (545), Expect = 7e-57
Identities = 179/530 (33%), Positives = 259/530 (48%), Gaps = 37/530 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRLH-YEITGGNTRGRFSITSQNGRG-- 421
F+ ++E+ E PG +A DAD E N L Y I + S +G
Sbjct: 130 FVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYP 189
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
++ + +PLD + + + L ++A D G S T + I +TDAN+ APVF Y S+
Sbjct: 190 VLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GT+VL V ATD D GINA+ITY+ L+S IS F +NP TG ITTN
Sbjct: 250 ENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL-------FNLNPNTGDITTNGT 302
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LD E S Y+L+V A+DGGV + +V+I +VD NDN P ++ I ED+ +GT
Sbjct: 303 LDFEETSRYVLSVEAKDGGVHTAH--CNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGT 360
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDL 655
++ + D D G NG + +EE F ++ S + AL+RE A +++
Sbjct: 361 VIALIKVRDKDSGQNGMVTCYT----QEEVPFKLESTSKNYYKLVIAGALNREQTADYNV 416
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+A D G P SS + + I DIND+ PVF ++SEN+P G +I ++ A DPD
Sbjct: 417 TIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPD 476
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV-TMVDLDYESPRKKYELVIRA---AS 771
GPN V YSI D L S ++ +V D+E R +EL ++A S
Sbjct: 477 LGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRA-FELTLQARDQGS 535
Query: 772 PPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPF-GRVPAYDADVT 824
P L +V + +LV D+NDNAP + D +F+ G +V A DAD
Sbjct: 536 PALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSG 595
Query: 825 DK--LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 596 HNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 645
Score = 168 bits (409), Expect = 2e-40
Identities = 135/474 (28%), Positives = 218/474 (45%), Gaps = 43/474 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H I V D ND++PVF + Y S++E GT+VL + ATDQD G NAE+ Y
Sbjct: 224 HIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAF----- 278
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
LN + +F ++ +G + T +LD E+ +RY + V+A D
Sbjct: 279 --LNSPIST-----------SLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVH-- 323
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
++ + + I+D+NDN P+ + +++ + ED + VIA IK D D G N +
Sbjct: 324 ---TAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDL--GTVIALIKVRDKDSGQNGMV 378
Query: 188 RYAIIGGNTQMQFSIDSLSGD---VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
++ F ++S S + + + L+ EQ Y + I A D G P+ S+ T +
Sbjct: 379 TCYT---QEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSIT 435
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
++I D+NDNAP F+ + + VSEN P G SI +V A D D G N ++Y++ D
Sbjct: 436 LHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPR 495
Query: 305 VDLP-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
L +++ P+SG V+ D E ++L + A D G P SA +
Sbjct: 496 ELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNA 555
Query: 364 XXFM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSI 414
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 616 GLRTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEV 667
Score = 155 bits (375), Expect = 3e-36
Identities = 142/484 (29%), Positives = 219/484 (45%), Gaps = 21/484 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + I D N+ AP F + E A G + SA D+DV N+ Y+++ N
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINP---N 172
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ + ++ + + K LDRE S + L +TA DGG P LS TT + I V D
Sbjct: 173 QYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDA 232
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN PVF Q++Y ++ E+ GTSV +V ATD D G+N I Y F ++P
Sbjct: 233 NDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSLFNLNP 292
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I TN LD E + + L A DGG ++ V I+I D ND+ P +
Sbjct: 293 NTGDITTNGTLDFEETSRYVLSVEAKDGGV--HTAHCNVQIEIVDENDNAPEVTFMSFSN 350
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I E+S +GT I I+ D D G N +V + + F LE+ + +LV L
Sbjct: 351 QIPEDSDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLES-TSKNYYKLVIAGAL 406
Query: 755 DYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
+ E Y + I A P L + + + ++D+NDNAPV + + ++ P
Sbjct: 407 NREQ-TADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGA 465
Query: 812 PFGRVPAYDADV--TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
+V A D D+ ++ Y IL+ + + E +++SPQ + A +
Sbjct: 466 SIAQVSASDPDLGPNGRVSYSILASD----LEPRELLSYVSVSPQSGVVFAQRAFDHEQL 521
Query: 870 TDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKE 929
++A Q S L + + L + LND A + L P LG L ++P E
Sbjct: 522 RAFELTLQARDQGSPAL-SANVSLRVLVGDLND-NAPRVLYPALGPDGSALFDMVPRAAE 579
Query: 930 NIYI 933
Y+
Sbjct: 580 PGYL 583
>BC103928-1|AAI03929.1| 810|Homo sapiens protocadherin gamma
subfamily B, 1 protein.
Length = 810
Score = 261 bits (640), Expect = 2e-68
Identities = 195/614 (31%), Positives = 294/614 (47%), Gaps = 41/614 (6%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D F + SG LL +DREK+ + + + V++ + + V I D NDN
Sbjct: 69 EDYFNVSLESGDLLVNGRIDREKICGRKL--ECALEFETVAENPMNVFHVVVVIQDINDN 126
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSL- 205
P+F K + + E S + A DADV NS Y I N FS+ +
Sbjct: 127 APRFVAKGIDLEICE--SALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLSTKE 181
Query: 206 SGDVS------LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
S D S L K LD E S+RL++ A DGG P S TT + I + D NDNAP F
Sbjct: 182 SPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ 241
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+++ S+ ENVP G S++RV A D DEG+NAE+TY + + ++ ++P +G +
Sbjct: 242 EVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL---FNLNPNTGDIT 298
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
T+G LD E ++Y L V A DGG FM + ++ ED
Sbjct: 299 TNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFM--SFSNQIPEDS 356
Query: 380 PPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYV 438
GT + + D D N + T + TS+N L+ +A L+ +Q Y
Sbjct: 357 DLGTVIALIKVRDKDSGQNGMVTCYTQEEVPFKLESTSKNYYKLV-IAGALNREQTADYN 415
Query: 439 LTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
+T+ ATD G S + ++I+D N+ APVF A Y V E+ P G ++ VSA+D
Sbjct: 416 VTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDP 475
Query: 497 DVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
D+G N +++YS L+S++ + + ++PQ+G + + D E + + LT+ ARD
Sbjct: 476 DLGPNDRVSYSILASDLEPRELLSY---VSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGA 605
G P+LS + + V D+NDN P + LY A + A G V++V A
Sbjct: 533 QGSPALSANVSLRVLVGDLNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVA 589
Query: 606 TDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G N + Y + + E G F + +G +RT +AL A L DGG P
Sbjct: 590 VDADSGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQP 648
Query: 666 PQSSTVIVHIKIED 679
P S+T +H+ D
Sbjct: 649 PLSATATLHLIFAD 662
Score = 240 bits (587), Expect = 6e-62
Identities = 179/606 (29%), Positives = 283/606 (46%), Gaps = 34/606 (5%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAPRFY 258
F++ SGD+ + +D E++ +L + + + + N +++ I+D+NDNAPRF
Sbjct: 72 FNVSLESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFV 131
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
+ E+ G A DAD N+ YT+ Y + +
Sbjct: 132 AKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVL 191
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
LDRE Q+ ++L++TA DGGDPP S T F Y V L E+
Sbjct: 192 LLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQEN 251
Query: 379 EPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQN---GRGLITVAQPLDFKQER 435
P GT V+ + ATD DE ++ EIT S + N G IT LDF++
Sbjct: 252 VPWGTSVLRVMATDQDEG--INAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETS 309
Query: 436 RYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
RYVL+V A D G + VQI I D N+ AP ++ + ED+ +GT + ++ D
Sbjct: 310 RYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRD 369
Query: 496 SDVGINAQITYSLSSEI--SNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D G N +T E+ E+ + + + VI GA L+RE + Y +T+ A
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVI---AGA------LNREQTADYNVTIIA 420
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLN 613
D G P+LS T + + + D+NDN PVF Q Y ++ E+ G S++QV A+D D+G N
Sbjct: 421 TDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPN 480
Query: 614 GRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
R+ Y + D + RE S+V + P SGV+ +A D E + +L A D G+P S+
Sbjct: 481 DRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSA 540
Query: 670 TVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVV 722
V + + + D+ND+ P + L + + G + ++ A D D G NA +
Sbjct: 541 NVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWL 600
Query: 723 HYSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLWNDVRV 780
Y + + FSL R G E+ T L D ++ R++ + +R PPL +
Sbjct: 601 SYHVLQASEPGLFSLGLRTG----EVRTARALGDRDAARQRLLVAVRDGGQPPLSATATL 656
Query: 781 EILVTD 786
++ D
Sbjct: 657 HLIFAD 662
Score = 222 bits (543), Expect = 1e-56
Identities = 179/530 (33%), Positives = 259/530 (48%), Gaps = 37/530 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRLH-YEITGGNTRGRFSITSQNGRG-- 421
F+ ++E+ E PG +A DAD E N L Y I + S +G
Sbjct: 130 FVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYP 189
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
++ + +PLD + + + L ++A D G S T + I +TDAN+ APVF Y S+
Sbjct: 190 VLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
E+ P GT+VL V ATD D GINA+ITY+ L+S IS F +NP TG ITTN
Sbjct: 250 ENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSL-------FNLNPNTGDITTNGT 302
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LD E S Y+L+V A+DGGV + +V+I +VD NDN P ++ I ED+ +GT
Sbjct: 303 LDFEETSRYVLSVEAKDGGVHTAH--CNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGT 360
Query: 599 SVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDL 655
++ + D D G NG + +EE F ++ S + AL+RE A +++
Sbjct: 361 VIALIKVRDKDSGQNGMVTCYT----QEEVPFKLESTSKNYYKLVIAGALNREQTADYNV 416
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+A D G P SS + + I DIND+ PVF ++SEN+P G +I ++ A DPD
Sbjct: 417 TIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPD 476
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV-TMVDLDYESPRKKYELVIRA---AS 771
GPN V YSI D L S ++ +V D+E R +EL ++A S
Sbjct: 477 LGPNDRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRA-FELTLQARDQGS 535
Query: 772 PPLWNDVRVEILVTDVNDNAPVM------KDFQIIFNNYKDCFPVGPF-GRVPAYDADVT 824
P L +V + +LV D+NDNAP + D +F+ G +V A DAD
Sbjct: 536 PALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSG 595
Query: 825 DK--LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 596 HNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 645
Score = 167 bits (407), Expect = 4e-40
Identities = 135/474 (28%), Positives = 218/474 (45%), Gaps = 43/474 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H I V D ND++PVF + Y S++E GT+VL + ATDQD G NAE+ Y
Sbjct: 224 HIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAF----- 278
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
LN + +F ++ +G + T +LD E+ +RY + V+A D
Sbjct: 279 --LNSPIST-----------SLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVH-- 323
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
++ + + I+D+NDN P+ + +++ + ED + VIA IK D D G N +
Sbjct: 324 ---TAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDL--GTVIALIKVRDKDSGQNGMV 378
Query: 188 RYAIIGGNTQMQFSIDSLSGD---VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
++ F ++S S + + + L+ EQ Y + I A D G P+ S+ T +
Sbjct: 379 TCYT---QEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSIT 435
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
++I D+NDNAP F+ + + VSEN P G SI +V A D D G N ++Y++ D
Sbjct: 436 LHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNDRVSYSILASDLEPR 495
Query: 305 VDLP-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
L +++ P+SG V+ D E ++L + A D G P SA +
Sbjct: 496 ELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNA 555
Query: 364 XXFM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSI 414
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 616 GLRTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEV 667
Score = 157 bits (382), Expect = 4e-37
Identities = 143/484 (29%), Positives = 220/484 (45%), Gaps = 21/484 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + I D N+ AP F + E A G + SA D+DV N+ Y+++ N
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINP---N 172
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ + ++ + + K LDRE S + L +TA DGG P LS TT + I V D
Sbjct: 173 QYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDA 232
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN PVF Q++Y ++ E+ GTSV +V ATD D G+N I Y F ++P
Sbjct: 233 NDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSLFNLNP 292
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I TN LD E + + L A DGG ++ V I+I D ND+ P +
Sbjct: 293 NTGDITTNGTLDFEETSRYVLSVEAKDGGV--HTAHCNVQIEIVDENDNAPEVTFMSFSN 350
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I E+S +GT I I+ D D G N +V + + F LE+ + +LV L
Sbjct: 351 QIPEDSDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLES-TSKNYYKLVIAGAL 406
Query: 755 DYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
+ E Y + I A P L + + + ++D+NDNAPV + + ++ P
Sbjct: 407 NREQ-TADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGA 465
Query: 812 PFGRVPAYDADV--TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
+V A D D+ D++ Y IL+ + + E +++SPQ + A +
Sbjct: 466 SIAQVSASDPDLGPNDRVSYSILASD----LEPRELLSYVSVSPQSGVVFAQRAFDHEQL 521
Query: 870 TDGVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTAEQFLSPLLGFFIDGLAAIIPCPKE 929
++A Q S L + + L + LND A + L P LG L ++P E
Sbjct: 522 RAFELTLQARDQGSPAL-SANVSLRVLVGDLND-NAPRVLYPALGPDGSALFDMVPRAAE 579
Query: 930 NIYI 933
Y+
Sbjct: 580 PGYL 583
>AJ564936-1|CAD92415.1| 787|Homo sapiens protocadherin protein.
Length = 787
Score = 259 bits (634), Expect = 1e-67
Identities = 176/542 (32%), Positives = 270/542 (49%), Gaps = 25/542 (4%)
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F + + S+ EN P+
Sbjct: 25 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 84
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLDRETQAK 331
G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G + LDRE
Sbjct: 85 GTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTGLITIKEPLDREETPN 142
Query: 332 YQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVT 387
++LLV A+DGG P A T P V L+E+ P T +
Sbjct: 143 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 202
Query: 388 LTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+T TD D D+ T R N + L+ A LD++ + Y + + A D+
Sbjct: 203 ITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDYESTKEYAIKLLAADA 261
Query: 447 G--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G + +AM+ I + D N+ APVF + T S+ E+ G + VSA D+D G NA+I
Sbjct: 262 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKI 321
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
Y L + E F ++ +TG +T K LDRE YL T+ A+D GVP L+
Sbjct: 322 NYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN 373
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD 624
V +S++D NDN PVF Y + E+ +V + TD D G N + L D
Sbjct: 374 VTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV--TLSILD 431
Query: 625 REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSP 684
E F ID +GVIR N + DRE ++ A DGG +SS+ V I + D+ND+
Sbjct: 432 -ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 490
Query: 685 PVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
PVF S+C + ++ GT + ++ A D D G NA V YSI GG+ + F+++
Sbjct: 491 PVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQET 550
Query: 742 GS 743
G+
Sbjct: 551 GN 552
Score = 246 bits (601), Expect = 1e-63
Identities = 181/602 (30%), Positives = 296/602 (49%), Gaps = 49/602 (8%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + LDRE+ Y + VK D P + SSTA + V++ D NDN+P F E VS
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFP---QRSSTAILQVSVTDTNDNHPVFKETEIEVS 77
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYA---IIGGNTQMQFSIDSLSGDVSLVKTL 215
+ E+ V + + ++ ATDAD+G N+ I ++ ++ + F +++ +G +++ + L
Sbjct: 78 IPENAPVGTS--VTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 135
Query: 216 DYEQVRSYRLVIRAQDGG-SPSRSNTTQLLINIRDVNDNAP----RFYTSLFQESV--SE 268
D E+ +++L++ A DGG P+R+ +L+N+ DVNDN P R+ + ++V SE
Sbjct: 136 DREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 192
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP---RSGWVYTSGQLD 325
N+P+ I + D D N +T TD ++P + P + T+ LD
Sbjct: 193 NIPLNTKIALITVTDKDADHNGRVT-CFTDH------EIPFRLRPVFSNQFLLETAAYLD 245
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E+ +Y + + A D G PP + +A F V + E+ PG +
Sbjct: 246 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 305
Query: 386 VTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
++A DAD + +++Y + G + FS+ + G++TV + LD ++E +Y+ T+ A
Sbjct: 306 TKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRT--GMLTVVKKLDREKEDKYLFTILA 362
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D+G + V ++I D N+ +PVF + Y V E+ P TV +++ TD D G N
Sbjct: 363 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 422
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
+ +T S+ E + F I+ QTG I N DRE Y V A DGG S
Sbjct: 423 SAVTLSILDE---------NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR 473
Query: 562 SDTTDVEISVVDVNDNEPVF---KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S + V I+VVDVNDN+PVF ++ GT V QV A D D G+N + Y
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKI 677
+ + + F ID +G I + D + H + A D G P S VIV++ +
Sbjct: 534 SIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 592
Query: 678 ED 679
+
Sbjct: 593 NE 594
Score = 236 bits (578), Expect = 7e-61
Identities = 184/612 (30%), Positives = 288/612 (47%), Gaps = 45/612 (7%)
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LDRE + Y + V DGG P RS+TA F + EV + E+ P G
Sbjct: 26 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
Query: 383 TPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T V L ATDAD E+ ++H+ + R F + + G LIT+ +PLD ++ +
Sbjct: 86 TSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG--LITIKEPLDREETPNH 143
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPYTASVFEDAPIGTTVLVV 491
L V A+D G AMV +N+TD N+ P + T + E+ P+ T + ++
Sbjct: 144 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
+ TD D N ++T EI QF++ T LD E+ Y + +
Sbjct: 204 TVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKL 256
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
A D G P L+ + + I V D NDN PVF Q T +I E+ G +++V A DAD G
Sbjct: 257 LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSG 316
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N +I+Y L P E F +D +G++ K LDRE + +A D G PP +S V
Sbjct: 317 PNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV 374
Query: 672 IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD 731
V + I D ND+ PVF + FY+ EN P T+G I DPD G N+ V SI D+
Sbjct: 375 TVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DE 432
Query: 732 SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVN 788
++ F+++++ G + + D E ++ Y ++A + +V I V DVN
Sbjct: 433 NDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVN 487
Query: 789 DNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--VTDKLQYRILSGNNANLI 840
DN PV F + +N Y+ P G +V A D D + +++Y I+ GN +L
Sbjct: 488 DNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 544
Query: 841 LLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRL 900
+++ TG++TL + + L + V D + V L E + N+ +
Sbjct: 545 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-- 602
Query: 901 NDMTAEQFLSPL 912
N++ + +P+
Sbjct: 603 NELVRKSTEAPV 614
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 56 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 114
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 115 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 154
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 155 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 214
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 215 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 271
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 272 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 327
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 328 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 386
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 387 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 444
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 445 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 504
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 505 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 557
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 558 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 616
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 617 NTEIADVSSPTSD 629
Score = 149 bits (362), Expect = 1e-34
Identities = 114/336 (33%), Positives = 163/336 (48%), Gaps = 19/336 (5%)
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ K LDRE Y++ V DGG P S T +++SV D NDN PVFK+ +I E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESV 650
+A VGTSV+Q+ ATDAD+G N +IH+ + F ++ +G+I + LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL------TFYISENSPIGT 704
H L +A DGG P + V+V+ + D+ND+ P + + T +SEN P+ T
Sbjct: 141 PNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 198
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
I I D D N V D F L S++ L T LDYES K+Y
Sbjct: 199 KIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQFLLETAAYLDYES-TKEYA 253
Query: 765 LVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
+ + AA PPL + I V D NDNAPV + + ++ P +V A DA
Sbjct: 254 IKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDA 313
Query: 822 DVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
D + L G +A L+ TG +T+ +L+
Sbjct: 314 DSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 349
>AJ564935-1|CAD92414.1| 762|Homo sapiens protocadherin protein.
Length = 762
Score = 259 bits (634), Expect = 1e-67
Identities = 176/542 (32%), Positives = 270/542 (49%), Gaps = 25/542 (4%)
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F + + S+ EN P+
Sbjct: 25 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 84
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLDRETQAK 331
G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G + LDRE
Sbjct: 85 GTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTGLITIKEPLDREETPN 142
Query: 332 YQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVT 387
++LLV A+DGG P A T P V L+E+ P T +
Sbjct: 143 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 202
Query: 388 LTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+T TD D D+ T R N + L+ A LD++ + Y + + A D+
Sbjct: 203 ITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDYESTKEYAIKLLAADA 261
Query: 447 G--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G + +AM+ I + D N+ APVF + T S+ E+ G + VSA D+D G NA+I
Sbjct: 262 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKI 321
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
Y L + E F ++ +TG +T K LDRE YL T+ A+D GVP L+
Sbjct: 322 NYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN 373
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD 624
V +S++D NDN PVF Y + E+ +V + TD D G N + L D
Sbjct: 374 VTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV--TLSILD 431
Query: 625 REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSP 684
E F ID +GVIR N + DRE ++ A DGG +SS+ V I + D+ND+
Sbjct: 432 -ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 490
Query: 685 PVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
PVF S+C + ++ GT + ++ A D D G NA V YSI GG+ + F+++
Sbjct: 491 PVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQET 550
Query: 742 GS 743
G+
Sbjct: 551 GN 552
Score = 246 bits (601), Expect = 1e-63
Identities = 181/602 (30%), Positives = 296/602 (49%), Gaps = 49/602 (8%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + LDRE+ Y + VK D P + SSTA + V++ D NDN+P F E VS
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFP---QRSSTAILQVSVTDTNDNHPVFKETEIEVS 77
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYA---IIGGNTQMQFSIDSLSGDVSLVKTL 215
+ E+ V + + ++ ATDAD+G N+ I ++ ++ + F +++ +G +++ + L
Sbjct: 78 IPENAPVGTS--VTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 135
Query: 216 DYEQVRSYRLVIRAQDGG-SPSRSNTTQLLINIRDVNDNAP----RFYTSLFQESV--SE 268
D E+ +++L++ A DGG P+R+ +L+N+ DVNDN P R+ + ++V SE
Sbjct: 136 DREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 192
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP---RSGWVYTSGQLD 325
N+P+ I + D D N +T TD ++P + P + T+ LD
Sbjct: 193 NIPLNTKIALITVTDKDADHNGRVT-CFTDH------EIPFRLRPVFSNQFLLETAAYLD 245
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E+ +Y + + A D G PP + +A F V + E+ PG +
Sbjct: 246 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 305
Query: 386 VTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
++A DAD + +++Y + G + FS+ + G++TV + LD ++E +Y+ T+ A
Sbjct: 306 TKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRT--GMLTVVKKLDREKEDKYLFTILA 362
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D+G + V ++I D N+ +PVF + Y V E+ P TV +++ TD D G N
Sbjct: 363 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 422
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
+ +T S+ E + F I+ QTG I N DRE Y V A DGG S
Sbjct: 423 SAVTLSILDE---------NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR 473
Query: 562 SDTTDVEISVVDVNDNEPVF---KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S + V I+VVDVNDN+PVF ++ GT V QV A D D G+N + Y
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKI 677
+ + + F ID +G I + D + H + A D G P S VIV++ +
Sbjct: 534 SIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 592
Query: 678 ED 679
+
Sbjct: 593 NE 594
Score = 236 bits (578), Expect = 7e-61
Identities = 184/612 (30%), Positives = 288/612 (47%), Gaps = 45/612 (7%)
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LDRE + Y + V DGG P RS+TA F + EV + E+ P G
Sbjct: 26 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
Query: 383 TPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T V L ATDAD E+ ++H+ + R F + + G LIT+ +PLD ++ +
Sbjct: 86 TSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG--LITIKEPLDREETPNH 143
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPYTASVFEDAPIGTTVLVV 491
L V A+D G AMV +N+TD N+ P + T + E+ P+ T + ++
Sbjct: 144 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
+ TD D N ++T EI QF++ T LD E+ Y + +
Sbjct: 204 TVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKL 256
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
A D G P L+ + + I V D NDN PVF Q T +I E+ G +++V A DAD G
Sbjct: 257 LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSG 316
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N +I+Y L P E F +D +G++ K LDRE + +A D G PP +S V
Sbjct: 317 PNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV 374
Query: 672 IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD 731
V + I D ND+ PVF + FY+ EN P T+G I DPD G N+ V SI D+
Sbjct: 375 TVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DE 432
Query: 732 SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVN 788
++ F+++++ G + + D E ++ Y ++A + +V I V DVN
Sbjct: 433 NDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVN 487
Query: 789 DNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--VTDKLQYRILSGNNANLI 840
DN PV F + +N Y+ P G +V A D D + +++Y I+ GN +L
Sbjct: 488 DNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 544
Query: 841 LLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRL 900
+++ TG++TL + + L + V D + V L E + N+ +
Sbjct: 545 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-- 602
Query: 901 NDMTAEQFLSPL 912
N++ + +P+
Sbjct: 603 NELVRKSTEAPV 614
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 56 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 114
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 115 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 154
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 155 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 214
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 215 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 271
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 272 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 327
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 328 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 386
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 387 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 444
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 445 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 504
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 505 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 557
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 558 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 616
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 617 NTEIADVSSPTSD 629
Score = 149 bits (362), Expect = 1e-34
Identities = 114/336 (33%), Positives = 163/336 (48%), Gaps = 19/336 (5%)
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ K LDRE Y++ V DGG P S T +++SV D NDN PVFK+ +I E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESV 650
+A VGTSV+Q+ ATDAD+G N +IH+ + F ++ +G+I + LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL------TFYISENSPIGT 704
H L +A DGG P + V+V+ + D+ND+ P + + T +SEN P+ T
Sbjct: 141 PNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 198
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
I I D D N V D F L S++ L T LDYES K+Y
Sbjct: 199 KIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQFLLETAAYLDYES-TKEYA 253
Query: 765 LVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
+ + AA PPL + I V D NDNAPV + + ++ P +V A DA
Sbjct: 254 IKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDA 313
Query: 822 DVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
D + L G +A L+ TG +T+ +L+
Sbjct: 314 DSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 349
>AJ564934-1|CAD92413.1| 841|Homo sapiens protocadherin protein.
Length = 841
Score = 259 bits (634), Expect = 1e-67
Identities = 176/542 (32%), Positives = 270/542 (49%), Gaps = 25/542 (4%)
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F + + S+ EN P+
Sbjct: 25 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 84
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLDRETQAK 331
G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G + LDRE
Sbjct: 85 GTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTGLITIKEPLDREETPN 142
Query: 332 YQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVT 387
++LLV A+DGG P A T P V L+E+ P T +
Sbjct: 143 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 202
Query: 388 LTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+T TD D D+ T R N + L+ A LD++ + Y + + A D+
Sbjct: 203 ITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDYESTKEYAIKLLAADA 261
Query: 447 G--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G + +AM+ I + D N+ APVF + T S+ E+ G + VSA D+D G NA+I
Sbjct: 262 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKI 321
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
Y L + E F ++ +TG +T K LDRE YL T+ A+D GVP L+
Sbjct: 322 NYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN 373
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD 624
V +S++D NDN PVF Y + E+ +V + TD D G N + L D
Sbjct: 374 VTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV--TLSILD 431
Query: 625 REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSP 684
E F ID +GVIR N + DRE ++ A DGG +SS+ V I + D+ND+
Sbjct: 432 -ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 490
Query: 685 PVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
PVF S+C + ++ GT + ++ A D D G NA V YSI GG+ + F+++
Sbjct: 491 PVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQET 550
Query: 742 GS 743
G+
Sbjct: 551 GN 552
Score = 246 bits (601), Expect = 1e-63
Identities = 181/602 (30%), Positives = 296/602 (49%), Gaps = 49/602 (8%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + LDRE+ Y + VK D P + SSTA + V++ D NDN+P F E VS
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFP---QRSSTAILQVSVTDTNDNHPVFKETEIEVS 77
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYA---IIGGNTQMQFSIDSLSGDVSLVKTL 215
+ E+ V + + ++ ATDAD+G N+ I ++ ++ + F +++ +G +++ + L
Sbjct: 78 IPENAPVGTS--VTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 135
Query: 216 DYEQVRSYRLVIRAQDGG-SPSRSNTTQLLINIRDVNDNAP----RFYTSLFQESV--SE 268
D E+ +++L++ A DGG P+R+ +L+N+ DVNDN P R+ + ++V SE
Sbjct: 136 DREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 192
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP---RSGWVYTSGQLD 325
N+P+ I + D D N +T TD ++P + P + T+ LD
Sbjct: 193 NIPLNTKIALITVTDKDADHNGRVT-CFTDH------EIPFRLRPVFSNQFLLETAAYLD 245
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E+ +Y + + A D G PP + +A F V + E+ PG +
Sbjct: 246 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 305
Query: 386 VTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
++A DAD + +++Y + G + FS+ + G++TV + LD ++E +Y+ T+ A
Sbjct: 306 TKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRT--GMLTVVKKLDREKEDKYLFTILA 362
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D+G + V ++I D N+ +PVF + Y V E+ P TV +++ TD D G N
Sbjct: 363 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 422
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
+ +T S+ E + F I+ QTG I N DRE Y V A DGG S
Sbjct: 423 SAVTLSILDE---------NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR 473
Query: 562 SDTTDVEISVVDVNDNEPVF---KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S + V I+VVDVNDN+PVF ++ GT V QV A D D G+N + Y
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKI 677
+ + + F ID +G I + D + H + A D G P S VIV++ +
Sbjct: 534 SIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 592
Query: 678 ED 679
+
Sbjct: 593 NE 594
Score = 236 bits (578), Expect = 7e-61
Identities = 184/612 (30%), Positives = 288/612 (47%), Gaps = 45/612 (7%)
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LDRE + Y + V DGG P RS+TA F + EV + E+ P G
Sbjct: 26 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
Query: 383 TPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T V L ATDAD E+ ++H+ + R F + + G LIT+ +PLD ++ +
Sbjct: 86 TSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG--LITIKEPLDREETPNH 143
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPYTASVFEDAPIGTTVLVV 491
L V A+D G AMV +N+TD N+ P + T + E+ P+ T + ++
Sbjct: 144 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
+ TD D N ++T EI QF++ T LD E+ Y + +
Sbjct: 204 TVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKL 256
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
A D G P L+ + + I V D NDN PVF Q T +I E+ G +++V A DAD G
Sbjct: 257 LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSG 316
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N +I+Y L P E F +D +G++ K LDRE + +A D G PP +S V
Sbjct: 317 PNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV 374
Query: 672 IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD 731
V + I D ND+ PVF + FY+ EN P T+G I DPD G N+ V SI D+
Sbjct: 375 TVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DE 432
Query: 732 SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVN 788
++ F+++++ G + + D E ++ Y ++A + +V I V DVN
Sbjct: 433 NDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVN 487
Query: 789 DNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--VTDKLQYRILSGNNANLI 840
DN PV F + +N Y+ P G +V A D D + +++Y I+ GN +L
Sbjct: 488 DNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 544
Query: 841 LLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRL 900
+++ TG++TL + + L + V D + V L E + N+ +
Sbjct: 545 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-- 602
Query: 901 NDMTAEQFLSPL 912
N++ + +P+
Sbjct: 603 NELVRKSTEAPV 614
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 56 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 114
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 115 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 154
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 155 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 214
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 215 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 271
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 272 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 327
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 328 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 386
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 387 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 444
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 445 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 504
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 505 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 557
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 558 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 616
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 617 NTEIADVSSPTSD 629
Score = 149 bits (362), Expect = 1e-34
Identities = 114/336 (33%), Positives = 163/336 (48%), Gaps = 19/336 (5%)
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ K LDRE Y++ V DGG P S T +++SV D NDN PVFK+ +I E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESV 650
+A VGTSV+Q+ ATDAD+G N +IH+ + F ++ +G+I + LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL------TFYISENSPIGT 704
H L +A DGG P + V+V+ + D+ND+ P + + T +SEN P+ T
Sbjct: 141 PNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 198
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
I I D D N V D F L S++ L T LDYES K+Y
Sbjct: 199 KIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQFLLETAAYLDYES-TKEYA 253
Query: 765 LVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
+ + AA PPL + I V D NDNAPV + + ++ P +V A DA
Sbjct: 254 IKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDA 313
Query: 822 DVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
D + L G +A L+ TG +T+ +L+
Sbjct: 314 DSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 349
>AJ564933-1|CAD92412.1| 831|Homo sapiens protocadherin protein.
Length = 831
Score = 259 bits (634), Expect = 1e-67
Identities = 176/542 (32%), Positives = 270/542 (49%), Gaps = 25/542 (4%)
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F + + S+ EN P+
Sbjct: 25 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 84
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLDRETQAK 331
G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G + LDRE
Sbjct: 85 GTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTGLITIKEPLDREETPN 142
Query: 332 YQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVT 387
++LLV A+DGG P A T P V L+E+ P T +
Sbjct: 143 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 202
Query: 388 LTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+T TD D D+ T R N + L+ A LD++ + Y + + A D+
Sbjct: 203 ITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLETAAYLDYESTKEYAIKLLAADA 261
Query: 447 G--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G + +AM+ I + D N+ APVF + T S+ E+ G + VSA D+D G NA+I
Sbjct: 262 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKI 321
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
Y L + E F ++ +TG +T K LDRE YL T+ A+D GVP L+
Sbjct: 322 NYLLGPDAPPE--------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN 373
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD 624
V +S++D NDN PVF Y + E+ +V + TD D G N + L D
Sbjct: 374 VTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV--TLSILD 431
Query: 625 REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSP 684
E F ID +GVIR N + DRE ++ A DGG +SS+ V I + D+ND+
Sbjct: 432 -ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 490
Query: 685 PVF---ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
PVF S+C + ++ GT + ++ A D D G NA V YSI GG+ + F+++
Sbjct: 491 PVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQET 550
Query: 742 GS 743
G+
Sbjct: 551 GN 552
Score = 246 bits (601), Expect = 1e-63
Identities = 181/602 (30%), Positives = 296/602 (49%), Gaps = 49/602 (8%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + LDRE+ Y + VK D P + SSTA + V++ D NDN+P F E VS
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFP---QRSSTAILQVSVTDTNDNHPVFKETEIEVS 77
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYA---IIGGNTQMQFSIDSLSGDVSLVKTL 215
+ E+ V + + ++ ATDAD+G N+ I ++ ++ + F +++ +G +++ + L
Sbjct: 78 IPENAPVGTS--VTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 135
Query: 216 DYEQVRSYRLVIRAQDGG-SPSRSNTTQLLINIRDVNDNAP----RFYTSLFQESV--SE 268
D E+ +++L++ A DGG P+R+ +L+N+ DVNDN P R+ + ++V SE
Sbjct: 136 DREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 192
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP---RSGWVYTSGQLD 325
N+P+ I + D D N +T TD ++P + P + T+ LD
Sbjct: 193 NIPLNTKIALITVTDKDADHNGRVT-CFTDH------EIPFRLRPVFSNQFLLETAAYLD 245
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E+ +Y + + A D G PP + +A F V + E+ PG +
Sbjct: 246 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 305
Query: 386 VTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
++A DAD + +++Y + G + FS+ + G++TV + LD ++E +Y+ T+ A
Sbjct: 306 TKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRT--GMLTVVKKLDREKEDKYLFTILA 362
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D+G + V ++I D N+ +PVF + Y V E+ P TV +++ TD D G N
Sbjct: 363 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDN 422
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
+ +T S+ E + F I+ QTG I N DRE Y V A DGG S
Sbjct: 423 SAVTLSILDE---------NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR 473
Query: 562 SDTTDVEISVVDVNDNEPVF---KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S + V I+VVDVNDN+PVF ++ GT V QV A D D G+N + Y
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKI 677
+ + + F ID +G I + D + H + A D G P S VIV++ +
Sbjct: 534 SIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 592
Query: 678 ED 679
+
Sbjct: 593 NE 594
Score = 236 bits (578), Expect = 7e-61
Identities = 184/612 (30%), Positives = 288/612 (47%), Gaps = 45/612 (7%)
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LDRE + Y + V DGG P RS+TA F + EV + E+ P G
Sbjct: 26 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
Query: 383 TPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T V L ATDAD E+ ++H+ + R F + + G LIT+ +PLD ++ +
Sbjct: 86 TSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG--LITIKEPLDREETPNH 143
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPYTASVFEDAPIGTTVLVV 491
L V A+D G AMV +N+TD N+ P + T + E+ P+ T + ++
Sbjct: 144 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
+ TD D N ++T EI QF++ T LD E+ Y + +
Sbjct: 204 TVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKL 256
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
A D G P L+ + + I V D NDN PVF Q T +I E+ G +++V A DAD G
Sbjct: 257 LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSG 316
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N +I+Y L P E F +D +G++ K LDRE + +A D G PP +S V
Sbjct: 317 PNAKINYLLGPDAPPE--FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV 374
Query: 672 IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD 731
V + I D ND+ PVF + FY+ EN P T+G I DPD G N+ V SI D+
Sbjct: 375 TVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DE 432
Query: 732 SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVN 788
++ F+++++ G + + D E ++ Y ++A + +V I V DVN
Sbjct: 433 NDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVN 487
Query: 789 DNAPVMKDFQIIFNN--YKDCFPVGPFG----RVPAYDAD--VTDKLQYRILSGNNANLI 840
DN PV F + +N Y+ P G +V A D D + +++Y I+ GN +L
Sbjct: 488 DNKPV---FIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 544
Query: 841 LLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRL 900
+++ TG++TL + + L + V D + V L E + N+ +
Sbjct: 545 AIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-- 602
Query: 901 NDMTAEQFLSPL 912
N++ + +P+
Sbjct: 603 NELVRKSTEAPV 614
Score = 215 bits (524), Expect = 3e-54
Identities = 170/613 (27%), Positives = 278/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 56 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 114
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 115 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 154
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 155 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 214
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++T LDYE + Y + + A D G P + +
Sbjct: 215 RVTCFT---DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 271
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G + +V A DAD G NA++ Y +
Sbjct: 272 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGP---- 327
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 328 -DAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 386
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 387 SPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 444
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF P S
Sbjct: 445 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYEL 504
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 505 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 557
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +
Sbjct: 558 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSTEAPVTP 616
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 617 NTEIADVSSPTSD 629
Score = 149 bits (362), Expect = 1e-34
Identities = 114/336 (33%), Positives = 163/336 (48%), Gaps = 19/336 (5%)
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ K LDRE Y++ V DGG P S T +++SV D NDN PVFK+ +I E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESV 650
+A VGTSV+Q+ ATDAD+G N +IH+ + F ++ +G+I + LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL------TFYISENSPIGT 704
H L +A DGG P + V+V+ + D+ND+ P + + T +SEN P+ T
Sbjct: 141 PNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 198
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
I I D D N V D F L S++ L T LDYES K+Y
Sbjct: 199 KIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQFLLETAAYLDYES-TKEYA 253
Query: 765 LVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
+ + AA PPL + I V D NDNAPV + + ++ P +V A DA
Sbjct: 254 IKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDA 313
Query: 822 DVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
D + L G +A L+ TG +T+ +L+
Sbjct: 314 DSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLD 349
>AJ564963-1|CAD92434.1| 787|Homo sapiens protocadherin protein.
Length = 787
Score = 256 bits (628), Expect = 6e-67
Identities = 175/542 (32%), Positives = 270/542 (49%), Gaps = 25/542 (4%)
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F + + S+ EN P+
Sbjct: 25 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 84
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLDRETQAK 331
G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G + LDRE
Sbjct: 85 GTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTGLITIKEPLDREETPN 142
Query: 332 YQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVT 387
++LLV A+DGG P A T P V L+E+ P T +
Sbjct: 143 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 202
Query: 388 LTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+T TD D D+ T R N + L+ A LD++ + Y + + A D+
Sbjct: 203 ITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLENAAYLDYESTKEYAIKLLAADA 261
Query: 447 G--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G + +AM+ I + D N+ APVF + T S+ E+ G ++ VSATD+D G NA+I
Sbjct: 262 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEI 321
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
Y L + E F ++ +TG +T K LDRE YL T+ A+D GVP L+
Sbjct: 322 NYLLGPDAPPE--------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN 373
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD 624
V +S++D NDN PVF Y + E+ +V + TD D G N + L D
Sbjct: 374 VTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAV--TLSILD 431
Query: 625 REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSP 684
E F ID +GVIR N + DRE ++ A DGG +SS+ V I + D+ND+
Sbjct: 432 -ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 490
Query: 685 PVFESDCLTF---YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
PVF + + ++ GT + ++ A D D G NA V YSI GG+ + F+++
Sbjct: 491 PVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQET 550
Query: 742 GS 743
G+
Sbjct: 551 GN 552
Score = 248 bits (607), Expect = 2e-64
Identities = 182/602 (30%), Positives = 298/602 (49%), Gaps = 49/602 (8%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + LDRE+ Y + VK D P + SSTA + V++ D NDN+P F E VS
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFP---QRSSTAILQVSVTDTNDNHPVFKETEIEVS 77
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYA---IIGGNTQMQFSIDSLSGDVSLVKTL 215
+ E+ V + + ++ ATDAD+G N+ I ++ ++ + F +++ +G +++ + L
Sbjct: 78 IPENAPVGTS--VTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 135
Query: 216 DYEQVRSYRLVIRAQDGG-SPSRSNTTQLLINIRDVNDNAP----RFYTSLFQESV--SE 268
D E+ +++L++ A DGG P+R+ +L+N+ DVNDN P R+ + ++V SE
Sbjct: 136 DREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 192
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP---RSGWVYTSGQLD 325
N+P+ I + D D N +T TD ++P + P + + LD
Sbjct: 193 NIPLNTKIALITVTDKDADHNGRVT-CFTDH------EIPFRLRPVFSNQFLLENAAYLD 245
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E+ +Y + + A D G PP + +A F V + E+ PG +
Sbjct: 246 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 305
Query: 386 VTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ ++ATDAD + ++Y + G + FS+ + G++TV + LD ++E +Y+ T+ A
Sbjct: 306 MKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTILA 362
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D+G + V ++I D N+ +PVF + Y V E+ P TV +++ TD D G N
Sbjct: 363 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDN 422
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
+ +T S+ E + F I+ QTG I N DRE Y V A DGG S
Sbjct: 423 SAVTLSILDE---------NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR 473
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDALVGTSVSQVGATDADVGLNGRIHY 618
S + V I+VVDVNDN+PVF Y + ++ GT V QV A D D G+N + Y
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKI 677
+ + + F ID +G I + D + H + A D G P S VIV++ +
Sbjct: 534 SIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 592
Query: 678 ED 679
+
Sbjct: 593 NE 594
Score = 236 bits (577), Expect = 1e-60
Identities = 182/610 (29%), Positives = 284/610 (46%), Gaps = 41/610 (6%)
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LDRE + Y + V DGG P RS+TA F + EV + E+ P G
Sbjct: 26 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
Query: 383 TPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T V L ATDAD E+ ++H+ + R F + + G LIT+ +PLD ++ +
Sbjct: 86 TSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG--LITIKEPLDREETPNH 143
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPYTASVFEDAPIGTTVLVV 491
L V A+D G AMV +N+TD N+ P + T + E+ P+ T + ++
Sbjct: 144 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
+ TD D N ++T EI QF++ LD E+ Y + +
Sbjct: 204 TVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKL 256
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
A D G P L+ + + I V D NDN PVF Q T +I E+ G + +V ATDAD G
Sbjct: 257 LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSG 316
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N I+Y L P E F +D +G++ K LDRE + +A D G PP +S V
Sbjct: 317 PNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV 374
Query: 672 IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD 731
V + I D ND+ PVF + FY+ EN P T+G I DPD G N+ V SI D+
Sbjct: 375 TVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DE 432
Query: 732 SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVN 788
++ F+++++ G + + D E ++ Y ++A + +V I V DVN
Sbjct: 433 NDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVN 487
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFG----RVPAYDAD--VTDKLQYRILSGNNANLILL 842
DN PV + +Y+ P G +V A D D + +++Y I+ GN +L +
Sbjct: 488 DNKPVFIVPPYNY-SYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAI 546
Query: 843 NETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLND 902
++ TG++TL + + L + V D + V L E + N+ + N+
Sbjct: 547 DQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI--NE 604
Query: 903 MTAEQFLSPL 912
+ + +P+
Sbjct: 605 LVRKSIEAPV 614
Score = 220 bits (537), Expect = 7e-56
Identities = 172/613 (28%), Positives = 281/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 56 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 114
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 115 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 154
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 155 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 214
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++ LDYE + Y + + A D G P + +
Sbjct: 215 RVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 271
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G +++V A DAD G NAE+ Y +
Sbjct: 272 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP---- 327
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 328 -DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 386
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y+ + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 387 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 444
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF PY S
Sbjct: 445 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYEL 504
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 505 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 557
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +I
Sbjct: 558 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSIEAPVTP 616
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 617 NTEIADVSSPTSD 629
Score = 149 bits (360), Expect = 2e-34
Identities = 113/336 (33%), Positives = 162/336 (48%), Gaps = 19/336 (5%)
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ K LDRE Y++ V DGG P S T +++SV D NDN PVFK+ +I E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESV 650
+A VGTSV+Q+ ATDAD+G N +IH+ + F ++ +G+I + LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL------TFYISENSPIGT 704
H L +A DGG P + V+V+ + D+ND+ P + + T +SEN P+ T
Sbjct: 141 PNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 198
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
I I D D N V D F L S++ L LDYES K+Y
Sbjct: 199 KIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQFLLENAAYLDYES-TKEYA 253
Query: 765 LVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
+ + AA PPL + I V D NDNAPV + + ++ P +V A DA
Sbjct: 254 IKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDA 313
Query: 822 DVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
D + L G +A L+ TG +T+ +L+
Sbjct: 314 DSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLD 349
>AJ564962-1|CAD92433.1| 762|Homo sapiens protocadherin protein.
Length = 762
Score = 256 bits (628), Expect = 6e-67
Identities = 175/542 (32%), Positives = 270/542 (49%), Gaps = 25/542 (4%)
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F + + S+ EN P+
Sbjct: 25 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 84
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLDRETQAK 331
G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G + LDRE
Sbjct: 85 GTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTGLITIKEPLDREETPN 142
Query: 332 YQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVT 387
++LLV A+DGG P A T P V L+E+ P T +
Sbjct: 143 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 202
Query: 388 LTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+T TD D D+ T R N + L+ A LD++ + Y + + A D+
Sbjct: 203 ITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLENAAYLDYESTKEYAIKLLAADA 261
Query: 447 G--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G + +AM+ I + D N+ APVF + T S+ E+ G ++ VSATD+D G NA+I
Sbjct: 262 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEI 321
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
Y L + E F ++ +TG +T K LDRE YL T+ A+D GVP L+
Sbjct: 322 NYLLGPDAPPE--------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN 373
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD 624
V +S++D NDN PVF Y + E+ +V + TD D G N + L D
Sbjct: 374 VTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAV--TLSILD 431
Query: 625 REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSP 684
E F ID +GVIR N + DRE ++ A DGG +SS+ V I + D+ND+
Sbjct: 432 -ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 490
Query: 685 PVFESDCLTF---YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
PVF + + ++ GT + ++ A D D G NA V YSI GG+ + F+++
Sbjct: 491 PVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQET 550
Query: 742 GS 743
G+
Sbjct: 551 GN 552
Score = 248 bits (607), Expect = 2e-64
Identities = 182/602 (30%), Positives = 298/602 (49%), Gaps = 49/602 (8%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + LDRE+ Y + VK D P + SSTA + V++ D NDN+P F E VS
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFP---QRSSTAILQVSVTDTNDNHPVFKETEIEVS 77
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYA---IIGGNTQMQFSIDSLSGDVSLVKTL 215
+ E+ V + + ++ ATDAD+G N+ I ++ ++ + F +++ +G +++ + L
Sbjct: 78 IPENAPVGTS--VTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 135
Query: 216 DYEQVRSYRLVIRAQDGG-SPSRSNTTQLLINIRDVNDNAP----RFYTSLFQESV--SE 268
D E+ +++L++ A DGG P+R+ +L+N+ DVNDN P R+ + ++V SE
Sbjct: 136 DREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 192
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP---RSGWVYTSGQLD 325
N+P+ I + D D N +T TD ++P + P + + LD
Sbjct: 193 NIPLNTKIALITVTDKDADHNGRVT-CFTDH------EIPFRLRPVFSNQFLLENAAYLD 245
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E+ +Y + + A D G PP + +A F V + E+ PG +
Sbjct: 246 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 305
Query: 386 VTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ ++ATDAD + ++Y + G + FS+ + G++TV + LD ++E +Y+ T+ A
Sbjct: 306 MKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTILA 362
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D+G + V ++I D N+ +PVF + Y V E+ P TV +++ TD D G N
Sbjct: 363 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDN 422
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
+ +T S+ E + F I+ QTG I N DRE Y V A DGG S
Sbjct: 423 SAVTLSILDE---------NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR 473
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDALVGTSVSQVGATDADVGLNGRIHY 618
S + V I+VVDVNDN+PVF Y + ++ GT V QV A D D G+N + Y
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKI 677
+ + + F ID +G I + D + H + A D G P S VIV++ +
Sbjct: 534 SIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 592
Query: 678 ED 679
+
Sbjct: 593 NE 594
Score = 236 bits (577), Expect = 1e-60
Identities = 182/610 (29%), Positives = 284/610 (46%), Gaps = 41/610 (6%)
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LDRE + Y + V DGG P RS+TA F + EV + E+ P G
Sbjct: 26 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
Query: 383 TPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T V L ATDAD E+ ++H+ + R F + + G LIT+ +PLD ++ +
Sbjct: 86 TSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG--LITIKEPLDREETPNH 143
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPYTASVFEDAPIGTTVLVV 491
L V A+D G AMV +N+TD N+ P + T + E+ P+ T + ++
Sbjct: 144 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
+ TD D N ++T EI QF++ LD E+ Y + +
Sbjct: 204 TVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKL 256
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
A D G P L+ + + I V D NDN PVF Q T +I E+ G + +V ATDAD G
Sbjct: 257 LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSG 316
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N I+Y L P E F +D +G++ K LDRE + +A D G PP +S V
Sbjct: 317 PNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV 374
Query: 672 IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD 731
V + I D ND+ PVF + FY+ EN P T+G I DPD G N+ V SI D+
Sbjct: 375 TVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DE 432
Query: 732 SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVN 788
++ F+++++ G + + D E ++ Y ++A + +V I V DVN
Sbjct: 433 NDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVN 487
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFG----RVPAYDAD--VTDKLQYRILSGNNANLILL 842
DN PV + +Y+ P G +V A D D + +++Y I+ GN +L +
Sbjct: 488 DNKPVFIVPPYNY-SYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAI 546
Query: 843 NETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLND 902
++ TG++TL + + L + V D + V L E + N+ + N+
Sbjct: 547 DQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI--NE 604
Query: 903 MTAEQFLSPL 912
+ + +P+
Sbjct: 605 LVRKSIEAPV 614
Score = 220 bits (537), Expect = 7e-56
Identities = 172/613 (28%), Positives = 281/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 56 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 114
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 115 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 154
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 155 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 214
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++ LDYE + Y + + A D G P + +
Sbjct: 215 RVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 271
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G +++V A DAD G NAE+ Y +
Sbjct: 272 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP---- 327
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 328 -DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 386
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y+ + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 387 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 444
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF PY S
Sbjct: 445 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYEL 504
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 505 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 557
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +I
Sbjct: 558 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSIEAPVTP 616
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 617 NTEIADVSSPTSD 629
Score = 149 bits (360), Expect = 2e-34
Identities = 113/336 (33%), Positives = 162/336 (48%), Gaps = 19/336 (5%)
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ K LDRE Y++ V DGG P S T +++SV D NDN PVFK+ +I E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESV 650
+A VGTSV+Q+ ATDAD+G N +IH+ + F ++ +G+I + LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL------TFYISENSPIGT 704
H L +A DGG P + V+V+ + D+ND+ P + + T +SEN P+ T
Sbjct: 141 PNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 198
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
I I D D N V D F L S++ L LDYES K+Y
Sbjct: 199 KIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQFLLENAAYLDYES-TKEYA 253
Query: 765 LVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
+ + AA PPL + I V D NDNAPV + + ++ P +V A DA
Sbjct: 254 IKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDA 313
Query: 822 DVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
D + L G +A L+ TG +T+ +L+
Sbjct: 314 DSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLD 349
>AJ564961-1|CAD92432.1| 841|Homo sapiens protocadherin protein.
Length = 841
Score = 256 bits (628), Expect = 6e-67
Identities = 175/542 (32%), Positives = 270/542 (49%), Gaps = 25/542 (4%)
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F + + S+ EN P+
Sbjct: 25 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 84
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLDRETQAK 331
G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G + LDRE
Sbjct: 85 GTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTGLITIKEPLDREETPN 142
Query: 332 YQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVT 387
++LLV A+DGG P A T P V L+E+ P T +
Sbjct: 143 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 202
Query: 388 LTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+T TD D D+ T R N + L+ A LD++ + Y + + A D+
Sbjct: 203 ITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLENAAYLDYESTKEYAIKLLAADA 261
Query: 447 G--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G + +AM+ I + D N+ APVF + T S+ E+ G ++ VSATD+D G NA+I
Sbjct: 262 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEI 321
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
Y L + E F ++ +TG +T K LDRE YL T+ A+D GVP L+
Sbjct: 322 NYLLGPDAPPE--------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN 373
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD 624
V +S++D NDN PVF Y + E+ +V + TD D G N + L D
Sbjct: 374 VTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAV--TLSILD 431
Query: 625 REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSP 684
E F ID +GVIR N + DRE ++ A DGG +SS+ V I + D+ND+
Sbjct: 432 -ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 490
Query: 685 PVFESDCLTF---YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
PVF + + ++ GT + ++ A D D G NA V YSI GG+ + F+++
Sbjct: 491 PVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQET 550
Query: 742 GS 743
G+
Sbjct: 551 GN 552
Score = 248 bits (607), Expect = 2e-64
Identities = 182/602 (30%), Positives = 298/602 (49%), Gaps = 49/602 (8%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + LDRE+ Y + VK D P + SSTA + V++ D NDN+P F E VS
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFP---QRSSTAILQVSVTDTNDNHPVFKETEIEVS 77
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYA---IIGGNTQMQFSIDSLSGDVSLVKTL 215
+ E+ V + + ++ ATDAD+G N+ I ++ ++ + F +++ +G +++ + L
Sbjct: 78 IPENAPVGTS--VTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 135
Query: 216 DYEQVRSYRLVIRAQDGG-SPSRSNTTQLLINIRDVNDNAP----RFYTSLFQESV--SE 268
D E+ +++L++ A DGG P+R+ +L+N+ DVNDN P R+ + ++V SE
Sbjct: 136 DREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 192
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP---RSGWVYTSGQLD 325
N+P+ I + D D N +T TD ++P + P + + LD
Sbjct: 193 NIPLNTKIALITVTDKDADHNGRVT-CFTDH------EIPFRLRPVFSNQFLLENAAYLD 245
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E+ +Y + + A D G PP + +A F V + E+ PG +
Sbjct: 246 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 305
Query: 386 VTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ ++ATDAD + ++Y + G + FS+ + G++TV + LD ++E +Y+ T+ A
Sbjct: 306 MKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTILA 362
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D+G + V ++I D N+ +PVF + Y V E+ P TV +++ TD D G N
Sbjct: 363 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDN 422
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
+ +T S+ E + F I+ QTG I N DRE Y V A DGG S
Sbjct: 423 SAVTLSILDE---------NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR 473
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDALVGTSVSQVGATDADVGLNGRIHY 618
S + V I+VVDVNDN+PVF Y + ++ GT V QV A D D G+N + Y
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKI 677
+ + + F ID +G I + D + H + A D G P S VIV++ +
Sbjct: 534 SIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 592
Query: 678 ED 679
+
Sbjct: 593 NE 594
Score = 236 bits (577), Expect = 1e-60
Identities = 182/610 (29%), Positives = 284/610 (46%), Gaps = 41/610 (6%)
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LDRE + Y + V DGG P RS+TA F + EV + E+ P G
Sbjct: 26 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
Query: 383 TPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T V L ATDAD E+ ++H+ + R F + + G LIT+ +PLD ++ +
Sbjct: 86 TSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG--LITIKEPLDREETPNH 143
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPYTASVFEDAPIGTTVLVV 491
L V A+D G AMV +N+TD N+ P + T + E+ P+ T + ++
Sbjct: 144 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
+ TD D N ++T EI QF++ LD E+ Y + +
Sbjct: 204 TVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKL 256
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
A D G P L+ + + I V D NDN PVF Q T +I E+ G + +V ATDAD G
Sbjct: 257 LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSG 316
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N I+Y L P E F +D +G++ K LDRE + +A D G PP +S V
Sbjct: 317 PNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV 374
Query: 672 IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD 731
V + I D ND+ PVF + FY+ EN P T+G I DPD G N+ V SI D+
Sbjct: 375 TVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DE 432
Query: 732 SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVN 788
++ F+++++ G + + D E ++ Y ++A + +V I V DVN
Sbjct: 433 NDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVN 487
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFG----RVPAYDAD--VTDKLQYRILSGNNANLILL 842
DN PV + +Y+ P G +V A D D + +++Y I+ GN +L +
Sbjct: 488 DNKPVFIVPPYNY-SYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAI 546
Query: 843 NETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLND 902
++ TG++TL + + L + V D + V L E + N+ + N+
Sbjct: 547 DQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI--NE 604
Query: 903 MTAEQFLSPL 912
+ + +P+
Sbjct: 605 LVRKSIEAPV 614
Score = 220 bits (537), Expect = 7e-56
Identities = 172/613 (28%), Positives = 281/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 56 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 114
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 115 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 154
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 155 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 214
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++ LDYE + Y + + A D G P + +
Sbjct: 215 RVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 271
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G +++V A DAD G NAE+ Y +
Sbjct: 272 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP---- 327
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 328 -DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 386
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y+ + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 387 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 444
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF PY S
Sbjct: 445 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYEL 504
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 505 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 557
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +I
Sbjct: 558 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSIEAPVTP 616
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 617 NTEIADVSSPTSD 629
Score = 149 bits (360), Expect = 2e-34
Identities = 113/336 (33%), Positives = 162/336 (48%), Gaps = 19/336 (5%)
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ K LDRE Y++ V DGG P S T +++SV D NDN PVFK+ +I E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESV 650
+A VGTSV+Q+ ATDAD+G N +IH+ + F ++ +G+I + LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL------TFYISENSPIGT 704
H L +A DGG P + V+V+ + D+ND+ P + + T +SEN P+ T
Sbjct: 141 PNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 198
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
I I D D N V D F L S++ L LDYES K+Y
Sbjct: 199 KIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQFLLENAAYLDYES-TKEYA 253
Query: 765 LVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
+ + AA PPL + I V D NDNAPV + + ++ P +V A DA
Sbjct: 254 IKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDA 313
Query: 822 DVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
D + L G +A L+ TG +T+ +L+
Sbjct: 314 DSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLD 349
>AJ564960-1|CAD92431.1| 831|Homo sapiens protocadherin protein.
Length = 831
Score = 256 bits (628), Expect = 6e-67
Identities = 175/542 (32%), Positives = 270/542 (49%), Gaps = 25/542 (4%)
Query: 213 KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
K LD E+ +Y + ++ +DGG P RS+T L +++ D NDN P F + + S+ EN P+
Sbjct: 25 KELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 84
Query: 273 GYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLDRETQAK 331
G S+ ++ A DAD G NA++ ++ + + N+ + ++ +G + LDRE
Sbjct: 85 GTSVTQLHATDADIGENAKIHFSFS--NLVSNIARRLFHLNATTGLITIKEPLDREETPN 142
Query: 332 YQLLVTATDGGDPPRSA----TATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVT 387
++LLV A+DGG P A T P V L+E+ P T +
Sbjct: 143 HKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIAL 202
Query: 388 LTATDADEDNRLHYE-ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+T TD D D+ T R N + L+ A LD++ + Y + + A D+
Sbjct: 203 ITVTDKDADHNGRVTCFTDHEIPFRLRPVFSN-QFLLENAAYLDYESTKEYAIKLLAADA 261
Query: 447 G--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G + +AM+ I + D N+ APVF + T S+ E+ G ++ VSATD+D G NA+I
Sbjct: 262 GKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEI 321
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
Y L + E F ++ +TG +T K LDRE YL T+ A+D GVP L+
Sbjct: 322 NYLLGPDAPPE--------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN 373
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD 624
V +S++D NDN PVF Y + E+ +V + TD D G N + L D
Sbjct: 374 VTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAV--TLSILD 431
Query: 625 REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSP 684
E F ID +GVIR N + DRE ++ A DGG +SS+ V I + D+ND+
Sbjct: 432 -ENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 490
Query: 685 PVFESDCLTF---YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
PVF + + ++ GT + ++ A D D G NA V YSI GG+ + F+++
Sbjct: 491 PVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQET 550
Query: 742 GS 743
G+
Sbjct: 551 GN 552
Score = 248 bits (607), Expect = 2e-64
Identities = 182/602 (30%), Positives = 298/602 (49%), Gaps = 49/602 (8%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + LDRE+ Y + VK D P + SSTA + V++ D NDN+P F E VS
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFP---QRSSTAILQVSVTDTNDNHPVFKETEIEVS 77
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYA---IIGGNTQMQFSIDSLSGDVSLVKTL 215
+ E+ V + + ++ ATDAD+G N+ I ++ ++ + F +++ +G +++ + L
Sbjct: 78 IPENAPVGTS--VTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPL 135
Query: 216 DYEQVRSYRLVIRAQDGG-SPSRSNTTQLLINIRDVNDNAP----RFYTSLFQESV--SE 268
D E+ +++L++ A DGG P+R+ +L+N+ DVNDN P R+ + ++V SE
Sbjct: 136 DREETPNHKLLVLASDGGLMPARA---MVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSE 192
Query: 269 NVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDP---RSGWVYTSGQLD 325
N+P+ I + D D N +T TD ++P + P + + LD
Sbjct: 193 NIPLNTKIALITVTDKDADHNGRVT-CFTDH------EIPFRLRPVFSNQFLLENAAYLD 245
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E+ +Y + + A D G PP + +A F V + E+ PG +
Sbjct: 246 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL 305
Query: 386 VTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ ++ATDAD + ++Y + G + FS+ + G++TV + LD ++E +Y+ T+ A
Sbjct: 306 MKVSATDADSGPNAEINY-LLGPDAPPEFSLDRRT--GMLTVVKKLDREKEDKYLFTILA 362
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D+G + V ++I D N+ +PVF + Y V E+ P TV +++ TD D G N
Sbjct: 363 KDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDN 422
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
+ +T S+ E + F I+ QTG I N DRE Y V A DGG S
Sbjct: 423 SAVTLSILDE---------NDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSR 473
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTAN---IMEDALVGTSVSQVGATDADVGLNGRIHY 618
S + V I+VVDVNDN+PVF Y + ++ GT V QV A D D G+N + Y
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKI 677
+ + + F ID +G I + D + H + A D G P S VIV++ +
Sbjct: 534 SIVGGNTRD-LFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFV 592
Query: 678 ED 679
+
Sbjct: 593 NE 594
Score = 236 bits (577), Expect = 1e-60
Identities = 182/610 (29%), Positives = 284/610 (46%), Gaps = 41/610 (6%)
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LDRE + Y + V DGG P RS+TA F + EV + E+ P G
Sbjct: 26 ELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
Query: 383 TPVVTLTATDAD--EDNRLHYE---ITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T V L ATDAD E+ ++H+ + R F + + G LIT+ +PLD ++ +
Sbjct: 86 TSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTG--LITIKEPLDREETPNH 143
Query: 438 VLTVSATDSGGRSDTAMVQINITDANNYAP------VFENAPYTASVFEDAPIGTTVLVV 491
L V A+D G AMV +N+TD N+ P + T + E+ P+ T + ++
Sbjct: 144 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 492 SATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTV 551
+ TD D N ++T EI QF++ LD E+ Y + +
Sbjct: 204 TVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKL 256
Query: 552 TARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVG 611
A D G P L+ + + I V D NDN PVF Q T +I E+ G + +V ATDAD G
Sbjct: 257 LAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSG 316
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N I+Y L P E F +D +G++ K LDRE + +A D G PP +S V
Sbjct: 317 PNAEINYLLGPDAPPE--FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV 374
Query: 672 IVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD 731
V + I D ND+ PVF + FY+ EN P T+G I DPD G N+ V SI D+
Sbjct: 375 TVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL--DE 432
Query: 732 SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVN 788
++ F+++++ G + + D E ++ Y ++A + +V I V DVN
Sbjct: 433 NDDFTIDSQTGVIRPN----ISFDREK-QESYTFYVKAEDGGRVSRSSSAKVTINVVDVN 487
Query: 789 DNAPVMKDFQIIFNNYKDCFPVGPFG----RVPAYDAD--VTDKLQYRILSGNNANLILL 842
DN PV + +Y+ P G +V A D D + +++Y I+ GN +L +
Sbjct: 488 DNKPVFIVPPYNY-SYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAI 546
Query: 843 NETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLITEEMLLNSITVRLND 902
++ TG++TL + + L + V D + V L E + N+ + N+
Sbjct: 547 DQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI--NE 604
Query: 903 MTAEQFLSPL 912
+ + +P+
Sbjct: 605 LVRKSIEAPV 614
Score = 220 bits (537), Expect = 7e-56
Identities = 172/613 (28%), Positives = 281/613 (45%), Gaps = 52/613 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
Q++V D ND+ PVF+ + E S+ E A GT+V L ATD DIG+NA++ ++ + ++
Sbjct: 56 QVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSN- 114
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F ++ +G + + LDRE+ + +LV A+D
Sbjct: 115 ---------------IARRLFHLNATTGLITIKEPLDREETPNHKLLVLASD-----GGL 154
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDN-PV---IAKIKATDADVGANS 185
+ + A + VN+ D NDN P + V++ + +++N P+ IA I TD D N
Sbjct: 155 MPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNG 214
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+ + ++ F + + + L++ LDYE + Y + + A D G P + +
Sbjct: 215 RVTCFT---DHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM 271
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
L I ++D NDNAP F S S+ EN G +++V A DAD G NAE+ Y +
Sbjct: 272 LFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP---- 327
Query: 303 GNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+ ++D R+G + +LDRE + KY + A D G PP ++ T
Sbjct: 328 -DAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDN 386
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGL 422
F +Y+ + E+ P V +T TD D + ++ + F+I SQ G+
Sbjct: 387 SPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQT--GV 444
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTAS--- 477
I D +++ Y V A D G RS +A V IN+ D N+ PVF PY S
Sbjct: 445 IRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYEL 504
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
V GT V V A D+D G+NA++ YS+ + + F I+ +TG IT +
Sbjct: 505 VLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-------FAIDQETGNITLME 557
Query: 538 LLDRETMSGYLLTVTARDGGVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
D + + + V A D G P SL V + V + N + +L +I
Sbjct: 558 KCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLI-NELVRKSIEAPVTP 616
Query: 597 GTSVSQVGATDAD 609
T ++ V + +D
Sbjct: 617 NTEIADVSSPTSD 629
Score = 149 bits (360), Expect = 2e-34
Identities = 113/336 (33%), Positives = 162/336 (48%), Gaps = 19/336 (5%)
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ K LDRE Y++ V DGG P S T +++SV D NDN PVFK+ +I E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELD--PKDREEGSFVIDPASGVIRTNKALDRESV 650
+A VGTSV+Q+ ATDAD+G N +IH+ + F ++ +G+I + LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL------TFYISENSPIGT 704
H L +A DGG P + V+V+ + D+ND+ P + + T +SEN P+ T
Sbjct: 141 PNHKLLVLASDGGLMPARAMVLVN--VTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNT 198
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
I I D D N V D F L S++ L LDYES K+Y
Sbjct: 199 KIALITVTDKDADHNGRVTCFT---DHEIPFRLRP-VFSNQFLLENAAYLDYES-TKEYA 253
Query: 765 LVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
+ + AA PPL + I V D NDNAPV + + ++ P +V A DA
Sbjct: 254 IKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDA 313
Query: 822 DVTDKLQYRILSGNNA-NLILLNETTGSMTLSPQLN 856
D + L G +A L+ TG +T+ +L+
Sbjct: 314 DSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLD 349
>BC035812-1|AAH35812.1| 1060|Homo sapiens protocadherin 1 protein.
Length = 1060
Score = 254 bits (622), Expect = 3e-66
Identities = 198/695 (28%), Positives = 314/695 (45%), Gaps = 48/695 (6%)
Query: 4 PFCIHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIE 63
P + QI V D ND++P F ++ E + G+ A+D+D G N Y ++
Sbjct: 149 PRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ 208
Query: 64 LVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQA 123
PE ++ + L+ +LDRE+ Y + +K D
Sbjct: 209 A------GPEAQELFGLQVAEDQEE------KQPQLIVMGNLDRERWDSYDLTIKVQDGG 256
Query: 124 SPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGA 183
SP +S+A + V ++D NDN P+F +Y + E+ + + + ++KA D+D GA
Sbjct: 257 SPPR---ASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHS--VIQVKANDSDQGA 311
Query: 184 NSAIRYAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
N+ I Y ++ +D +G +++ +D E + + R + A+D G+ +S
Sbjct: 312 NAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARA 371
Query: 242 QLLINIRDVNDNAPRFYTS-----LFQE---SVSENVPIGYSIVRVQAYDADEGVNAELT 293
Q+++ ++D+NDNAP Q+ ++SE+V ++ VQ D DEG NA +T
Sbjct: 372 QVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVT 431
Query: 294 YTMT-DKDYTGNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATAT 351
+ D + D + + + T+ LD E Y + + A D G+PP S+T +
Sbjct: 432 CVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNS 491
Query: 352 XXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNT- 408
F EV E+ PG + +TA+DAD + L Y +
Sbjct: 492 LKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAA 551
Query: 409 RGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRS--DTAMVQINITDANNYA 466
+G F+I+ + G I V LD +Q Y L V A D G S TA V +N+ D N+
Sbjct: 552 KGLFTISPETGE--IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDND 609
Query: 467 PVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
P F + Y SV E+ P + V +V+ D D G NAQ+ S+ + + FVI
Sbjct: 610 PKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQD---------NGDFVI 660
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLY 586
TG I ++ DRE S Y + A DGGVP S V I+V+D NDN P
Sbjct: 661 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSN 720
Query: 587 TAN--IMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA 644
T++ + +G +VSQV A D D G+N + Y + G F I SG I K
Sbjct: 721 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI-AGGNPYGLFQIGSHSGAITLEKE 779
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIED 679
++R H L D G PP+ T +VH+ + +
Sbjct: 780 IERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 814
Score = 250 bits (612), Expect = 5e-65
Identities = 185/648 (28%), Positives = 289/648 (44%), Gaps = 28/648 (4%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
I ++D+NDN P F + + ++ EN IG A D D G N +Y +
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 305 V-DLPITIDP--RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+ L + D + + G LDRE Y L + DGG PPR+++A
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTND 275
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRG--RFSITSQNG 419
F YE EL+E+ P G V+ + A D+D+ E T R +
Sbjct: 276 NAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRN 335
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFE------- 470
GLITV P+D + +V A D G +A Q+ +T D N+ AP E
Sbjct: 336 TGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLV 395
Query: 471 -NAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ A++ ED T V +V +D D G NA +T ++ ++ + + + + +
Sbjct: 396 THQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQ-LRQASETGSDSKK 454
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
+ T LD E + Y + + A D G P LS T +++ VVDVNDN PVF Q +
Sbjct: 455 KYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVA 514
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRES 649
E+ G ++++ A+DAD G N + Y L+P+ +G F I P +G I+ +LDRE
Sbjct: 515 FPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQ 574
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
+++LK VA D G+P T V + + D ND+ P F F + EN P + +G +
Sbjct: 575 RESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMV 634
Query: 710 RAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
D D+G NA V S++ D+ F ++ G+ + L D + +S +
Sbjct: 635 TVIDGDKGENAQVQLSVE--QDNGDFVIQNGTGTILSSL--SFDREQQSTYTFQLKAVDG 690
Query: 770 ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPA------YDADV 823
PP V V I V D NDNAP + ++K P G + +D+ V
Sbjct: 691 GVPPRSAYVGVTINVLDENDNAPYIT--APSNTSHKLLTPQTRLGETVSQVAAEDFDSGV 748
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+L Y I GN L + +G++TL ++ L + V V+D
Sbjct: 749 NAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSD 796
Score = 234 bits (573), Expect = 3e-60
Identities = 195/648 (30%), Positives = 295/648 (45%), Gaps = 70/648 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD ND++P FE YEA + E + G +V+ +KA D D G NAE+EYT
Sbjct: 267 RVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQA---- 322
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
PE V+ + R+D +G + + +DRE ++ V A D+ + +
Sbjct: 323 --PE-----------VVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT---NP 366
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDED----IS--VTDNPVIAKIKATDADVGA 183
S+ A + V + D NDN P + + +D IS V + +A ++ +D D G
Sbjct: 367 KSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGE 426
Query: 184 NSAIRYAIIGGNTQMQFSIDSLSGDVSLVK-------TLDYEQVRSYRLVIRAQDGGSPS 236
N+A+ ++ G+ Q S +G S K LDYE+V+ Y + I A D G+P
Sbjct: 427 NAAVT-CVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPP 485
Query: 237 RSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM 296
S+T L + + DVNDNAP F S+ + + EN G I + A DAD G NAEL Y++
Sbjct: 486 LSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL 545
Query: 297 TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXX 356
+ + TI P +G + LDRE + Y+L V A D G P TAT
Sbjct: 546 EPEPAAKGL---FTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNV 602
Query: 357 XXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITS 416
FM Y + E+ P +PV +T D D+ +++ G F I
Sbjct: 603 LDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVI-- 660
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
QNG G I + D +Q+ Y + A D G RS V IN+ D N+ AP + AP
Sbjct: 661 QNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAP-YITAPS 719
Query: 475 TAS---VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
S + +G TV V+A D D G+NA++ YS+ A + F I +G
Sbjct: 720 NTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI-------AGGNPYGLFQIGSHSG 772
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
AIT K ++R + L V D G P T V + V NE + + L
Sbjct: 773 AITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV-----NETLANRTLL----- 822
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVI 639
+ L+G S+ T D+ + G YE + ++ G+ + +GV+
Sbjct: 823 -ETLLGHSLD----TPLDIDIAGDPEYE---RSKQRGNILFGVVAGVV 862
Score = 183 bits (445), Expect = 9e-45
Identities = 153/507 (30%), Positives = 239/507 (47%), Gaps = 40/507 (7%)
Query: 429 LDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGT 486
LD ++ Y LT+ D G R+ +A++++ + D N+ AP FE Y A + E++PIG
Sbjct: 238 LDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGH 297
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
+V+ V A DSD G NA+I Y+ + E V + ++ TG IT +DRE +S
Sbjct: 298 SVIQVKANDSDQGANAEIEYTFHQ--APEVVR---RLLRLDRNTGLITVQGPVDREDLST 352
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQ---LYT-----ANIMEDALVGT 598
+V A+D G S V ++V D+NDN P + + L T ANI ED T
Sbjct: 353 LRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEET 412
Query: 599 SVSQVGATDADVGLN--------GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESV 650
+V+ V +D D G N G + ++L E GS ++T LD E V
Sbjct: 413 AVALVQVSDRDEGENAAVTCVVAGDVPFQLRQAS-ETGSD--SKKKYFLQTTTPLDYEKV 469
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
+ ++ VA+D G PP SST + +++ D+ND+ PVF EN+ G I EI
Sbjct: 470 KDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEIT 529
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
A D D G NA + YS++ + F++ G E+ LD E R+ YEL + A
Sbjct: 530 ASDADSGSNAELVYSLEPEPAAKGLFTISPETG----EIQVKTSLDREQ-RESYELKVVA 584
Query: 770 A---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDK 826
A SP L V + V D NDN P F+ ++ + P G V D D +
Sbjct: 585 ADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGEN 644
Query: 827 LQYRI-LSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSV 884
Q ++ + +N + ++ N TG++ S + T ++ D GV A + +++
Sbjct: 645 AQVQLSVEQDNGDFVIQN-GTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTI 703
Query: 885 RLITEEMLLNSITVRLNDMTAEQFLSP 911
++ E IT N T+ + L+P
Sbjct: 704 NVLDENDNAPYITAPSN--TSHKLLTP 728
Score = 150 bits (364), Expect = 6e-35
Identities = 127/422 (30%), Positives = 195/422 (46%), Gaps = 39/422 (9%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL-----SS 510
QI + D N+ P F + T ++ E+ IG+ + A+D D G N +Y L +
Sbjct: 155 QIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 511 EISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEIS 570
E+ VA ++ PQ + N LDRE Y LT+ +DGG P + + + ++
Sbjct: 215 ELFGLQVAEDQEE--KQPQL-IVMGN--LDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269
Query: 571 VVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSF 630
V+D NDN P F++ Y A + E++ +G SV QV A D+D G N I Y
Sbjct: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329
Query: 631 V-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFES 689
+ +D +G+I +DRE ++T +A D GT P+S+ V + ++D+ND+ P E
Sbjct: 330 LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEI 389
Query: 690 DCLTFY--------ISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQ 741
+ ISE+ T + ++ D DEG NA V + GD +
Sbjct: 390 RGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAV-TCVVAGDVPFQLRQASET 448
Query: 742 GSD---KAELVTMVDLDYESPRK-KYELV-IRAASPPLWNDVRVEILVTDVNDNAPVMKD 796
GSD K L T LDYE + E+V + + +PPL + +++ V DVNDNAPV
Sbjct: 449 GSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQ 508
Query: 797 FQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQYRILSGNNANLILLNE----TTGSMTLS 852
++ P + A DAD SG+NA L+ E G T+S
Sbjct: 509 SVTEVAFPENNKPGEVIAEITASDAD----------SGSNAELVYSLEPEPAAKGLFTIS 558
Query: 853 PQ 854
P+
Sbjct: 559 PE 560
>AF152522-1|AAD43782.1| 820|Homo sapiens protocadherin gamma B6
short form protein protein.
Length = 820
Score = 254 bits (621), Expect = 4e-66
Identities = 181/626 (28%), Positives = 295/626 (47%), Gaps = 38/626 (6%)
Query: 197 QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAP 255
++ FS+D+ SGD+ + +D EQ+ R Q + + N +++ I DVND+AP
Sbjct: 72 KLHFSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAP 131
Query: 256 RFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRS 315
+F + E+ G + A D D +N+ Y + Y L + ++
Sbjct: 132 QFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSNPY---FSLMVRVNSDG 188
Query: 316 G---WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYE 372
G + LDRE Q + L++TA DGGDPPRSATA F +Y
Sbjct: 189 GKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYR 248
Query: 373 VELAEDEPPGTPVVTLTATDADE----DNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
+ L+E+ PPG+PV+ +TATD DE + ++ T +T+ FS+ + G+I Q
Sbjct: 249 ISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKT--GMIKNNQS 306
Query: 429 LDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTV 488
DF+ RY + V A D GG S V I I D N+ +P + + E++P G V
Sbjct: 307 FDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPGMVV 366
Query: 489 LVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYL 548
+ D D G N ++ ++ ++I + + + + + T+ LDRE Y
Sbjct: 367 ALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYY-------KLVTDGALDREQTPEYN 419
Query: 549 LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDA 608
+T+ A D G P LS + + + V D+NDN PVF Q Y ++ E+ G S++QV A+D
Sbjct: 420 VTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDP 479
Query: 609 DVGLNGRIHYELDPKDREE---GSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGT 664
D+GLNG I Y + D E S+V + SGV+ +A D E + L A D G+
Sbjct: 480 DLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGS 539
Query: 665 PPQSSTVIVHIKIEDINDSP-----PVFESDCLTFY--ISENSPIGTTIGEIRAHDPDEG 717
P S+ V + + + D ND+ P D F+ + ++ G + ++ A D D G
Sbjct: 540 PTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSG 599
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLW 775
NA + Y + + FSL R G E+ T L D ++ R++ + +R PPL
Sbjct: 600 HNAWLSYHVLQASEPGLFSLGLRTG----EVRTARALGDRDAARQRLLVAVRDGGQPPLS 655
Query: 776 NDVRVEILVTD-VNDNAPVMKDFQII 800
+ ++ D + + P + D ++
Sbjct: 656 ATATLHLVFADNLQEILPDLSDRPVL 681
Score = 239 bits (586), Expect = 8e-62
Identities = 181/605 (29%), Positives = 282/605 (46%), Gaps = 28/605 (4%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F +D SG LL + +DRE++ + + Q V + + + V I D ND+ PQ
Sbjct: 75 FSVDAESGDLLVKNRIDREQICKERRRCEL--QLEAVVENPLNIFHVIVVIEDVNDHAPQ 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNT-QMQFSIDSLSG- 207
F +K + + E S ++ ATD D+ NS Y I + ++S G
Sbjct: 133 FDKKEIHLEIFESASAGTR--LSLDPATDPDININSIKDYKINSNPYFSLMVRVNSDGGK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++SL K LD E+ RS+ L++ A DGG P RS T + I+++D NDN P F ++ S
Sbjct: 191 YPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRIS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SEN+P G +++V A D DEGVNAE+ Y + + ++D ++G + + D
Sbjct: 251 LSENLPPGSPVLQVTATDQDEGVNAEINYYF--RSTAQSTKHMFSLDEKTGMIKNNQSFD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y + V A DGG S + ++ E+ PPG V
Sbjct: 309 FEDVERYTMEVEAKDGGG--LSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPGMVV 366
Query: 386 VTLTATDADEDNRLHYEITGGNTRGRFSI-TSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
D D T F I +S N + LD +Q Y +T+ AT
Sbjct: 367 ALFKTRDLDFGGNGEVR-CNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVAT 425
Query: 445 DSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINA 502
D G S + + + + D N+ APVF+ Y V E+ P G ++ VSA+D D+G+N
Sbjct: 426 DRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNG 485
Query: 503 QITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
I+YS+ +S++ AV+ + ++ Q+G + + D E + + LT+ ARD G P+L
Sbjct: 486 HISYSIVASDLEPLAVSSY---VSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTL 542
Query: 562 SDTTDVEISVVDVNDNEP-VFKQQL------YTANIMEDALVGTSVSQVGATDADVGLNG 614
S + + V D NDN P V L + + A G V++V A DAD G N
Sbjct: 543 SANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNA 602
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
+ Y + + E G F + +G +RT +AL A L DGG PP S+T +H
Sbjct: 603 WLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLH 661
Query: 675 IKIED 679
+ D
Sbjct: 662 LVFAD 666
Score = 200 bits (487), Expect = 8e-50
Identities = 166/587 (28%), Positives = 264/587 (44%), Gaps = 59/587 (10%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F+ ++ + E AS+GT + ATD DI N+ +Y I
Sbjct: 118 HVIVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKI----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
NP + V G+ L LDRE+ +++++ A D P
Sbjct: 173 -NSNP---------YFSLMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPR 222
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
S+TA I +++ D NDN P FS Y +S+ E++ +PV+ ++ ATD D G N+ I
Sbjct: 223 ---SATAHIEISVKDTNDNPPVFSRDEYRISLSENLP-PGSPVL-QVTATDQDEGVNAEI 277
Query: 188 RYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y +T+ FS+D +G + ++ D+E V Y + + A+DGG S +++I
Sbjct: 278 NYYFRSTAQSTKHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGG--GLSTQCKVII 335
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D NDN+P + + + EN P G + + D D G N E+ +
Sbjct: 336 EILDENDNSPEIIITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRCNI-------ET 388
Query: 306 DLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
D+P I S Y T G LDRE +Y + + ATD G PP S++ +
Sbjct: 389 DIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVATDRGKPPLSSSRSITLYVADINDN 448
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGN-----TRGRFSIT 415
F Y V +AE+ PPG + ++A+D D + + Y I + S++
Sbjct: 449 APVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSIVASDLEPLAVSSYVSVS 508
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP--VFEN 471
+Q+ G++ + D +Q R + LT+ A D G + +A V + + D N+ AP ++
Sbjct: 509 AQS--GVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPA 566
Query: 472 APYTASVFED-----APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
S F D A G V V A D+D G NA ++Y + A F +
Sbjct: 567 LGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSL 619
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+TG + T + L + L V RDGG P LS T + + D
Sbjct: 620 GLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 666
Score = 190 bits (463), Expect = 6e-47
Identities = 160/528 (30%), Positives = 253/528 (47%), Gaps = 40/528 (7%)
Query: 370 QYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFS----ITSQNGR-GL 422
+ +E+ E GT + ATD D + N + Y+I N+ FS + S G+
Sbjct: 137 EIHLEIFESASAGTRLSLDPATDPDININSIKDYKI---NSNPYFSLMVRVNSDGGKYPE 193
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+++ + LD +++R + L ++A D G RS TA ++I++ D N+ PVF Y S+ E
Sbjct: 194 LSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRISLSE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ P G+ VL V+ATD D G+NA+I Y S + ++ H F ++ +TG I N+ D
Sbjct: 254 NLPPGSPVLQVTATDQDEGVNAEINYYFRS--TAQSTKH---MFSLDEKTGMIKNNQSFD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + V A+DGG LS V I ++D NDN P + I+E++ G V
Sbjct: 309 FEDVERYTMEVEAKDGG--GLSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPGMVV 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ D D G NG + ++ + F I +S + T+ ALDRE +++
Sbjct: 367 ALFKTRDLDFGGNGEVRCNIET----DIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTI 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
VA D G PP SS+ + + + DIND+ PVF+ +++EN+P G +I ++ A DPD G
Sbjct: 423 VATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLG 482
Query: 718 PNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N + YSI D + + S + + D+E R + L ++A SP
Sbjct: 483 LNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLR-AFALTLQARDHGSPT 541
Query: 774 LWNDVRVEILVTDVNDNAP------VMKDFQIIFNNY-KDCFPVGPFGRVPAYDADVTDK 826
L +V + +LV D NDNAP + D F+ + P +V A DAD
Sbjct: 542 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHN 601
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 602 AWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 649
Score = 164 bits (399), Expect = 4e-39
Identities = 135/472 (28%), Positives = 206/472 (43%), Gaps = 46/472 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H +I+V D ND+ PVF +Y S+ E G+ VL + ATDQD G NAE+ Y
Sbjct: 227 HIEISVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQ 286
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
T + +F +D ++G + S D E V RYT+ V+A D
Sbjct: 287 ST-----------------KHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGGG--- 326
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNP--VIAKIKATDADVGANS 185
LS+ + + I+D+NDN P+ S+ + I P V+A K D D G N
Sbjct: 327 --LSTQCKVIIEILDENDNSPEI----IITSLSDQILENSPPGMVVALFKTRDLDFGGNG 380
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+R I T + F I S S + + T LD EQ Y + I A D G P S++
Sbjct: 381 EVRCNI---ETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVATDRGKPPLSSSRS 437
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D+NDNAP F + + V+EN P G SI +V A D D G+N ++Y++ D
Sbjct: 438 ITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSIVASDLE 497
Query: 303 G-NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
V +++ +SG V+ D E + L + A D G P SA +
Sbjct: 498 PLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRND 557
Query: 362 XXXXFM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRF 412
+ G ++ PG V + A DAD + L Y + + G F
Sbjct: 558 NAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLF 617
Query: 413 SITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANN 464
S+ + G + A+ L + R L V+ D G +A +++ A+N
Sbjct: 618 SLGLRTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADN 667
>AF152335-1|AAD43729.1| 930|Homo sapiens protocadherin gamma B6
protein.
Length = 930
Score = 254 bits (621), Expect = 4e-66
Identities = 181/626 (28%), Positives = 295/626 (47%), Gaps = 38/626 (6%)
Query: 197 QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAP 255
++ FS+D+ SGD+ + +D EQ+ R Q + + N +++ I DVND+AP
Sbjct: 72 KLHFSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAP 131
Query: 256 RFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRS 315
+F + E+ G + A D D +N+ Y + Y L + ++
Sbjct: 132 QFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSNPY---FSLMVRVNSDG 188
Query: 316 G---WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYE 372
G + LDRE Q + L++TA DGGDPPRSATA F +Y
Sbjct: 189 GKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYR 248
Query: 373 VELAEDEPPGTPVVTLTATDADE----DNRLHYEITGGNTRGRFSITSQNGRGLITVAQP 428
+ L+E+ PPG+PV+ +TATD DE + ++ T +T+ FS+ + G+I Q
Sbjct: 249 ISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKT--GMIKNNQS 306
Query: 429 LDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTV 488
DF+ RY + V A D GG S V I I D N+ +P + + E++P G V
Sbjct: 307 FDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPGMVV 366
Query: 489 LVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYL 548
+ D D G N ++ ++ ++I + + + + + T+ LDRE Y
Sbjct: 367 ALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYY-------KLVTDGALDREQTPEYN 419
Query: 549 LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDA 608
+T+ A D G P LS + + + V D+NDN PVF Q Y ++ E+ G S++QV A+D
Sbjct: 420 VTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDP 479
Query: 609 DVGLNGRIHYELDPKDREE---GSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGT 664
D+GLNG I Y + D E S+V + SGV+ +A D E + L A D G+
Sbjct: 480 DLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGS 539
Query: 665 PPQSSTVIVHIKIEDINDSP-----PVFESDCLTFY--ISENSPIGTTIGEIRAHDPDEG 717
P S+ V + + + D ND+ P D F+ + ++ G + ++ A D D G
Sbjct: 540 PTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSG 599
Query: 718 PNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLW 775
NA + Y + + FSL R G E+ T L D ++ R++ + +R PPL
Sbjct: 600 HNAWLSYHVLQASEPGLFSLGLRTG----EVRTARALGDRDAARQRLLVAVRDGGQPPLS 655
Query: 776 NDVRVEILVTD-VNDNAPVMKDFQII 800
+ ++ D + + P + D ++
Sbjct: 656 ATATLHLVFADNLQEILPDLSDRPVL 681
Score = 239 bits (586), Expect = 8e-62
Identities = 181/605 (29%), Positives = 282/605 (46%), Gaps = 28/605 (4%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F +D SG LL + +DRE++ + + Q V + + + V I D ND+ PQ
Sbjct: 75 FSVDAESGDLLVKNRIDREQICKERRRCEL--QLEAVVENPLNIFHVIVVIEDVNDHAPQ 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNT-QMQFSIDSLSG- 207
F +K + + E S ++ ATD D+ NS Y I + ++S G
Sbjct: 133 FDKKEIHLEIFESASAGTR--LSLDPATDPDININSIKDYKINSNPYFSLMVRVNSDGGK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++SL K LD E+ RS+ L++ A DGG P RS T + I+++D NDN P F ++ S
Sbjct: 191 YPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRIS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SEN+P G +++V A D DEGVNAE+ Y + + ++D ++G + + D
Sbjct: 251 LSENLPPGSPVLQVTATDQDEGVNAEINYYF--RSTAQSTKHMFSLDEKTGMIKNNQSFD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y + V A DGG S + ++ E+ PPG V
Sbjct: 309 FEDVERYTMEVEAKDGGG--LSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPGMVV 366
Query: 386 VTLTATDADEDNRLHYEITGGNTRGRFSI-TSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
D D T F I +S N + LD +Q Y +T+ AT
Sbjct: 367 ALFKTRDLDFGGNGEVR-CNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVAT 425
Query: 445 DSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINA 502
D G S + + + + D N+ APVF+ Y V E+ P G ++ VSA+D D+G+N
Sbjct: 426 DRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNG 485
Query: 503 QITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
I+YS+ +S++ AV+ + ++ Q+G + + D E + + LT+ ARD G P+L
Sbjct: 486 HISYSIVASDLEPLAVSSY---VSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTL 542
Query: 562 SDTTDVEISVVDVNDNEP-VFKQQL------YTANIMEDALVGTSVSQVGATDADVGLNG 614
S + + V D NDN P V L + + A G V++V A DAD G N
Sbjct: 543 SANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNA 602
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
+ Y + + E G F + +G +RT +AL A L DGG PP S+T +H
Sbjct: 603 WLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLH 661
Query: 675 IKIED 679
+ D
Sbjct: 662 LVFAD 666
Score = 200 bits (487), Expect = 8e-50
Identities = 166/587 (28%), Positives = 264/587 (44%), Gaps = 59/587 (10%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F+ ++ + E AS+GT + ATD DI N+ +Y I
Sbjct: 118 HVIVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKI----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
NP + V G+ L LDRE+ +++++ A D P
Sbjct: 173 -NSNP---------YFSLMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPR 222
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
S+TA I +++ D NDN P FS Y +S+ E++ +PV+ ++ ATD D G N+ I
Sbjct: 223 ---SATAHIEISVKDTNDNPPVFSRDEYRISLSENLP-PGSPVL-QVTATDQDEGVNAEI 277
Query: 188 RYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y +T+ FS+D +G + ++ D+E V Y + + A+DGG S +++I
Sbjct: 278 NYYFRSTAQSTKHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGG--GLSTQCKVII 335
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D NDN+P + + + EN P G + + D D G N E+ +
Sbjct: 336 EILDENDNSPEIIITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRCNI-------ET 388
Query: 306 DLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
D+P I S Y T G LDRE +Y + + ATD G PP S++ +
Sbjct: 389 DIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVATDRGKPPLSSSRSITLYVADINDN 448
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGN-----TRGRFSIT 415
F Y V +AE+ PPG + ++A+D D + + Y I + S++
Sbjct: 449 APVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSIVASDLEPLAVSSYVSVS 508
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP--VFEN 471
+Q+ G++ + D +Q R + LT+ A D G + +A V + + D N+ AP ++
Sbjct: 509 AQS--GVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPA 566
Query: 472 APYTASVFED-----APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
S F D A G V V A D+D G NA ++Y + A F +
Sbjct: 567 LGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSL 619
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+TG + T + L + L V RDGG P LS T + + D
Sbjct: 620 GLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 666
Score = 190 bits (463), Expect = 6e-47
Identities = 160/528 (30%), Positives = 253/528 (47%), Gaps = 40/528 (7%)
Query: 370 QYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFS----ITSQNGR-GL 422
+ +E+ E GT + ATD D + N + Y+I N+ FS + S G+
Sbjct: 137 EIHLEIFESASAGTRLSLDPATDPDININSIKDYKI---NSNPYFSLMVRVNSDGGKYPE 193
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+++ + LD +++R + L ++A D G RS TA ++I++ D N+ PVF Y S+ E
Sbjct: 194 LSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRISLSE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ P G+ VL V+ATD D G+NA+I Y S + ++ H F ++ +TG I N+ D
Sbjct: 254 NLPPGSPVLQVTATDQDEGVNAEINYYFRS--TAQSTKH---MFSLDEKTGMIKNNQSFD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + V A+DGG LS V I ++D NDN P + I+E++ G V
Sbjct: 309 FEDVERYTMEVEAKDGG--GLSTQCKVIIEILDENDNSPEIIITSLSDQILENSPPGMVV 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ D D G NG + ++ + F I +S + T+ ALDRE +++
Sbjct: 367 ALFKTRDLDFGGNGEVRCNIET----DIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTI 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
VA D G PP SS+ + + + DIND+ PVF+ +++EN+P G +I ++ A DPD G
Sbjct: 423 VATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLG 482
Query: 718 PNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N + YSI D + + S + + D+E R + L ++A SP
Sbjct: 483 LNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLR-AFALTLQARDHGSPT 541
Query: 774 LWNDVRVEILVTDVNDNAP------VMKDFQIIFNNY-KDCFPVGPFGRVPAYDADVTDK 826
L +V + +LV D NDNAP + D F+ + P +V A DAD
Sbjct: 542 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHN 601
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 602 AWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 649
Score = 164 bits (399), Expect = 4e-39
Identities = 135/472 (28%), Positives = 206/472 (43%), Gaps = 46/472 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H +I+V D ND+ PVF +Y S+ E G+ VL + ATDQD G NAE+ Y
Sbjct: 227 HIEISVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQ 286
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
T + +F +D ++G + S D E V RYT+ V+A D
Sbjct: 287 ST-----------------KHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGGG--- 326
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNP--VIAKIKATDADVGANS 185
LS+ + + I+D+NDN P+ S+ + I P V+A K D D G N
Sbjct: 327 --LSTQCKVIIEILDENDNSPEI----IITSLSDQILENSPPGMVVALFKTRDLDFGGNG 380
Query: 186 AIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
+R I T + F I S S + + T LD EQ Y + I A D G P S++
Sbjct: 381 EVRCNI---ETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVATDRGKPPLSSSRS 437
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+ + + D+NDNAP F + + V+EN P G SI +V A D D G+N ++Y++ D
Sbjct: 438 ITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSIVASDLE 497
Query: 303 G-NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
V +++ +SG V+ D E + L + A D G P SA +
Sbjct: 498 PLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRND 557
Query: 362 XXXXFM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRF 412
+ G ++ PG V + A DAD + L Y + + G F
Sbjct: 558 NAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLF 617
Query: 413 SITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANN 464
S+ + G + A+ L + R L V+ D G +A +++ A+N
Sbjct: 618 SLGLRTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADN 667
>BC112083-1|AAI12084.1| 878|Homo sapiens protocadherin gamma
subfamily C, 5, isoform 2 precursor protein.
Length = 878
Score = 252 bits (618), Expect = 1e-65
Identities = 178/617 (28%), Positives = 277/617 (44%), Gaps = 24/617 (3%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SGAL +DRE + + Q V++ + V I+D NDN P
Sbjct: 75 FSLSLMSGALAVNQKIDRESLCGASTSCLLPVQV--VTEHPLELIRVEVEILDLNDNSPS 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F+ + + E S A D DVG N+ Y + N+ ++ +L
Sbjct: 133 FATPEREMRISE--SAASGARFPLDSAQDPDVGTNTVSFYTL-SPNSHFSLNVKTLKDGK 189
Query: 208 ---DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++ L + LD E ++LV+ A DGG+P+RS TT + + + D+NDNAP F +S+ +
Sbjct: 190 PFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRV 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
+ EN PIG ++R+ A D DEG N +L Y+ D +L +DP SG ++ G +
Sbjct: 250 GIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNL-FGLDPSSGAIHVLGPI 308
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ A D G P + + E P GT
Sbjct: 309 DFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLANPVLESTPVGTV 368
Query: 385 VVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
V D D + S+N L+T +QPLD + Y++ + A+
Sbjct: 369 VGLFNVRDRDSGRNGEVSLDISPDLPFQIKPSENHYSLLT-SQPLDREATSHYIIELLAS 427
Query: 445 DSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINA 502
D+G S +++NI+D N+ AP F YTA + E+ P G+ + V+A+D D G NA
Sbjct: 428 DAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNA 487
Query: 503 QITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
++TYS+ + N+ FV +NP+ G I + D E + + V RD G P L
Sbjct: 488 RLTYSI---VGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPL 544
Query: 562 SDTTDVEISVVDVNDNEPVFK------QQLYTANIMEDALVGTSVSQVGATDADVGLNGR 615
T + + V+D NDN P + + A G+ V++V A DAD G N
Sbjct: 545 HANTSLHVFVLDENDNAPAVLHPRPGWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAW 604
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y L P+ G F++ +G +RT +AL + T + + D G P SST V +
Sbjct: 605 LSYSLLPQSTAPGLFLVSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLL 664
Query: 676 KIEDINDSPPVFESDCL 692
+ED + SD L
Sbjct: 665 VLEDEDPEEMPKSSDFL 681
Score = 214 bits (523), Expect = 3e-54
Identities = 166/578 (28%), Positives = 260/578 (44%), Gaps = 39/578 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT-DKDYTG 303
+ I D+NDN+P F T + +SE+ G A D D G N YT++ + ++
Sbjct: 121 VEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSL 180
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
NV P V QLDRE QA++QL++TA DGG P RS T
Sbjct: 181 NVKTLKDGKPFPELVLEQ-QLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI---TGGNTRGRFSITSQN 418
F V + E+ P GT ++ L ATD DE + +L Y T R F + +
Sbjct: 240 PTFQSSVLRVGIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNLFGLDPSS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G I V P+DF++ R Y + A D G ++Q+++ D N+ AP A
Sbjct: 300 GA--IHVLGPIDFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLAN 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG--AIT 534
V E P+GT V + + D D G N +++ +S ++ F I P ++
Sbjct: 358 PVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISPDLP----------FQIKPSENHYSLL 407
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T++ LDRE S Y++ + A D G PSL + +++ DVNDN P F QQLYTA I+E+
Sbjct: 408 TSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENR 467
Query: 595 LVGTSVSQVGATDADVGLNGRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESV 650
G+ + V A+D D G N R+ Y + + SFV ++P G I + D E +
Sbjct: 468 PPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELL 527
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFE------SDCLTFYISENSPIGT 704
+ D G+PP + +H+ + D ND+ P + ++P G+
Sbjct: 528 QMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAVLHPRPGWEHSAPQRLPRSAPPGS 587
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDS-NSFSLETRQGSDKAELVTMVDLDYESPRKKY 763
+ ++ A D D G NA + YS+ + F + T G + + D +S ++
Sbjct: 588 LVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTHTGEVRTARALLED---DSDTQQV 644
Query: 764 ELVIRAASPPLWNDVRVEILVTDVND--NAPVMKDFQI 799
+++R P + +LV + D P DF I
Sbjct: 645 VVLVRDNGDPSLSSTATVLLVLEDEDPEEMPKSSDFLI 682
Score = 198 bits (483), Expect = 2e-49
Identities = 167/593 (28%), Positives = 266/593 (44%), Gaps = 57/593 (9%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
I ++ +LD ND+SP F + E + E A+SG A D D+G N YT+ +
Sbjct: 117 IRVEVEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNS 176
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASP 125
+LN + DG+ L+ LDRE AR+ +++ A D +P
Sbjct: 177 HFSLNVKTLK----------------DGKPFPELVLEQQLDREAQARHQLVLTAVDGGTP 220
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S T I V ++D NDN P F V + E+ + ++ ++ ATD D G N
Sbjct: 221 AR---SGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPI--GTLLLRLNATDPDEGTNG 275
Query: 186 AIRYAIIGGNT----QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
+ Y+ G +T + F +D SG + ++ +D+E+ R Y + RA+D G P+
Sbjct: 276 QLDYS-FGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARDQGQPAMEGHC 334
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ +++ DVNDNAP + V E+ P+G + D D G N E++ ++
Sbjct: 335 VIQVDVGDVNDNAPEVLLASLANPVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISP--- 391
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
DLP I P + TS LDRE + Y + + A+D G P T
Sbjct: 392 ----DLPFQIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDV 447
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRG--RFSIT 415
F Y + E+ PPG+ + T+ A+D D DN RL Y I G +G S
Sbjct: 448 NDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFV 507
Query: 416 SQNGR-GLITVAQPLDFKQERRYVLTVSATDSGG---RSDTAMVQINITDANNYAP-VFE 470
N G I + D++ + + V DSG ++T++ + + D N+ AP V
Sbjct: 508 YVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSL-HVFVLDENDNAPAVLH 566
Query: 471 NAP---YTA--SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFV 525
P ++A + AP G+ V V+A D+D G NA ++YSL + + + F+
Sbjct: 567 PRPGWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGL------FL 620
Query: 526 INPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNE 578
++ TG + T + L + + V RD G PSLS T V + + D + E
Sbjct: 621 VSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDPEE 673
Score = 132 bits (318), Expect = 2e-29
Identities = 103/329 (31%), Positives = 156/329 (47%), Gaps = 27/329 (8%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E++ GT V V+ D+G+ S ++ +E + + F ++ +GA+ N
Sbjct: 34 SVVEESEPGTLVGNVA---QDLGLKMTDLLSRRLQLGSE---ENGRYFSLSLMSGALAVN 87
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+ +DRE++ G + V + VE+ ++D+NDN P F I E A
Sbjct: 88 QKIDRESLCGASTSCLLPVQVVTEHPLELIRVEVEILDLNDNSPSFATPEREMRISESAA 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVI----DPASGVIRTNKALDRESVA 651
G A D DVG N Y L P + P ++ + LDRE+ A
Sbjct: 148 SGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELV-LEQQLDREAQA 206
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
H L A+DGGTP +S T ++ + + DIND+ P F+S L I EN+PIGT + + A
Sbjct: 207 RHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRLNA 266
Query: 712 HDPDEGPNAVVHYSIKGGDDS-----NSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
DPDEG N + YS GD + N F L+ G+ + + +D+E R YE+
Sbjct: 267 TDPDEGTNGQLDYSF--GDHTSEAVRNLFGLDPSSGA----IHVLGPIDFEESR-FYEIH 319
Query: 767 IRA---ASPPLWNDVRVEILVTDVNDNAP 792
RA P + +++ V DVNDNAP
Sbjct: 320 ARARDQGQPAMEGHCVIQVDVGDVNDNAP 348
>BC112081-1|AAI12082.1| 878|Homo sapiens protocadherin gamma
subfamily C, 5, isoform 2 precursor protein.
Length = 878
Score = 252 bits (618), Expect = 1e-65
Identities = 178/617 (28%), Positives = 277/617 (44%), Gaps = 24/617 (3%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SGAL +DRE + + Q V++ + V I+D NDN P
Sbjct: 75 FSLSLMSGALAVNQKIDRESLCGASTSCLLPVQV--VTEHPLELIRVEVEILDLNDNSPS 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F+ + + E S A D DVG N+ Y + N+ ++ +L
Sbjct: 133 FATPEREMRISE--SAASGARFPLDSAQDPDVGTNTVSFYTL-SPNSHFSLNVKTLKDGK 189
Query: 208 ---DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++ L + LD E ++LV+ A DGG+P+RS TT + + + D+NDNAP F +S+ +
Sbjct: 190 PFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRV 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
+ EN PIG ++R+ A D DEG N +L Y+ D +L +DP SG ++ G +
Sbjct: 250 GIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNL-FGLDPSSGAIHVLGPI 308
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ A D G P + + E P GT
Sbjct: 309 DFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLANPVLESTPVGTV 368
Query: 385 VVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
V D D + S+N L+T +QPLD + Y++ + A+
Sbjct: 369 VGLFNVRDRDSGRNGEVSLDISPDLPFQIKPSENHYSLLT-SQPLDREATSHYIIELLAS 427
Query: 445 DSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINA 502
D+G S +++NI+D N+ AP F YTA + E+ P G+ + V+A+D D G NA
Sbjct: 428 DAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNA 487
Query: 503 QITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
++TYS+ + N+ FV +NP+ G I + D E + + V RD G P L
Sbjct: 488 RLTYSI---VGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPL 544
Query: 562 SDTTDVEISVVDVNDNEPVFK------QQLYTANIMEDALVGTSVSQVGATDADVGLNGR 615
T + + V+D NDN P + + A G+ V++V A DAD G N
Sbjct: 545 HANTSLHVFVLDENDNAPAVLHPRPGWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAW 604
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y L P+ G F++ +G +RT +AL + T + + D G P SST V +
Sbjct: 605 LSYSLLPQSTAPGLFLVSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLL 664
Query: 676 KIEDINDSPPVFESDCL 692
+ED + SD L
Sbjct: 665 VLEDEDPEEMPKSSDFL 681
Score = 214 bits (523), Expect = 3e-54
Identities = 166/578 (28%), Positives = 260/578 (44%), Gaps = 39/578 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT-DKDYTG 303
+ I D+NDN+P F T + +SE+ G A D D G N YT++ + ++
Sbjct: 121 VEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSL 180
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
NV P V QLDRE QA++QL++TA DGG P RS T
Sbjct: 181 NVKTLKDGKPFPELVLEQ-QLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI---TGGNTRGRFSITSQN 418
F V + E+ P GT ++ L ATD DE + +L Y T R F + +
Sbjct: 240 PTFQSSVLRVGIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNLFGLDPSS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G I V P+DF++ R Y + A D G ++Q+++ D N+ AP A
Sbjct: 300 GA--IHVLGPIDFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLAN 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG--AIT 534
V E P+GT V + + D D G N +++ +S ++ F I P ++
Sbjct: 358 PVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISPDLP----------FQIKPSENHYSLL 407
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T++ LDRE S Y++ + A D G PSL + +++ DVNDN P F QQLYTA I+E+
Sbjct: 408 TSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENR 467
Query: 595 LVGTSVSQVGATDADVGLNGRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESV 650
G+ + V A+D D G N R+ Y + + SFV ++P G I + D E +
Sbjct: 468 PPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELL 527
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFE------SDCLTFYISENSPIGT 704
+ D G+PP + +H+ + D ND+ P + ++P G+
Sbjct: 528 QMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAVLHPRPGWEHSAPQRLPRSAPPGS 587
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDS-NSFSLETRQGSDKAELVTMVDLDYESPRKKY 763
+ ++ A D D G NA + YS+ + F + T G + + D +S ++
Sbjct: 588 LVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTHTGEVRTARALLED---DSDTQQV 644
Query: 764 ELVIRAASPPLWNDVRVEILVTDVND--NAPVMKDFQI 799
+++R P + +LV + D P DF I
Sbjct: 645 VVLVRDNGDPSLSSTATVLLVLEDEDPEEMPKSSDFLI 682
Score = 198 bits (483), Expect = 2e-49
Identities = 167/593 (28%), Positives = 266/593 (44%), Gaps = 57/593 (9%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
I ++ +LD ND+SP F + E + E A+SG A D D+G N YT+ +
Sbjct: 117 IRVEVEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNS 176
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASP 125
+LN + DG+ L+ LDRE AR+ +++ A D +P
Sbjct: 177 HFSLNVKTLK----------------DGKPFPELVLEQQLDREAQARHQLVLTAVDGGTP 220
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S T I V ++D NDN P F V + E+ + ++ ++ ATD D G N
Sbjct: 221 AR---SGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPI--GTLLLRLNATDPDEGTNG 275
Query: 186 AIRYAIIGGNT----QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
+ Y+ G +T + F +D SG + ++ +D+E+ R Y + RA+D G P+
Sbjct: 276 QLDYS-FGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARDQGQPAMEGHC 334
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ +++ DVNDNAP + V E+ P+G + D D G N E++ ++
Sbjct: 335 VIQVDVGDVNDNAPEVLLASLANPVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISP--- 391
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
DLP I P + TS LDRE + Y + + A+D G P T
Sbjct: 392 ----DLPFQIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDV 447
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRG--RFSIT 415
F Y + E+ PPG+ + T+ A+D D DN RL Y I G +G S
Sbjct: 448 NDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFV 507
Query: 416 SQNGR-GLITVAQPLDFKQERRYVLTVSATDSGG---RSDTAMVQINITDANNYAP-VFE 470
N G I + D++ + + V DSG ++T++ + + D N+ AP V
Sbjct: 508 YVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSL-HVFVLDENDNAPAVLH 566
Query: 471 NAP---YTA--SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFV 525
P ++A + AP G+ V V+A D+D G NA ++YSL + + + F+
Sbjct: 567 PRPGWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGL------FL 620
Query: 526 INPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNE 578
++ TG + T + L + + V RD G PSLS T V + + D + E
Sbjct: 621 VSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDPEE 673
Score = 132 bits (318), Expect = 2e-29
Identities = 103/329 (31%), Positives = 156/329 (47%), Gaps = 27/329 (8%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E++ GT V V+ D+G+ S ++ +E + + F ++ +GA+ N
Sbjct: 34 SVVEESEPGTLVGNVA---QDLGLKMTDLLSRRLQLGSE---ENGRYFSLSLMSGALAVN 87
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+ +DRE++ G + V + VE+ ++D+NDN P F I E A
Sbjct: 88 QKIDRESLCGASTSCLLPVQVVTEHPLELIRVEVEILDLNDNSPSFATPEREMRISESAA 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVI----DPASGVIRTNKALDRESVA 651
G A D DVG N Y L P + P ++ + LDRE+ A
Sbjct: 148 SGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELV-LEQQLDREAQA 206
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
H L A+DGGTP +S T ++ + + DIND+ P F+S L I EN+PIGT + + A
Sbjct: 207 RHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRLNA 266
Query: 712 HDPDEGPNAVVHYSIKGGDDS-----NSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
DPDEG N + YS GD + N F L+ G+ + + +D+E R YE+
Sbjct: 267 TDPDEGTNGQLDYSF--GDHTSEAVRNLFGLDPSSGA----IHVLGPIDFEESR-FYEIH 319
Query: 767 IRA---ASPPLWNDVRVEILVTDVNDNAP 792
RA P + +++ V DVNDNAP
Sbjct: 320 ARARDQGQPAMEGHCVIQVDVGDVNDNAP 348
>AF152526-1|AAD43786.1| 878|Homo sapiens protocadherin gamma C5
short form protein protein.
Length = 878
Score = 252 bits (618), Expect = 1e-65
Identities = 178/617 (28%), Positives = 277/617 (44%), Gaps = 24/617 (3%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SGAL +DRE + + Q V++ + V I+D NDN P
Sbjct: 75 FSLSLMSGALAVNQKIDRESLCGASTSCLLPVQV--VTEHPLELIRVEVEILDLNDNSPS 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F+ + + E S A D DVG N+ Y + N+ ++ +L
Sbjct: 133 FATPEREMRISE--SAASGARFPLDSAQDPDVGTNTVSFYTL-SPNSHFSLNVKTLKDGK 189
Query: 208 ---DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++ L + LD E ++LV+ A DGG+P+RS TT + + + D+NDNAP F +S+ +
Sbjct: 190 PFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRV 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
+ EN PIG ++R+ A D DEG N +L Y+ D +L +DP SG ++ G +
Sbjct: 250 GIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNL-FGLDPSSGAIHVLGPI 308
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ A D G P + + E P GT
Sbjct: 309 DFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLANPVLESTPVGTV 368
Query: 385 VVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
V D D + S+N L+T +QPLD + Y++ + A+
Sbjct: 369 VGLFNVRDRDSGRNGEVSLDISPDLPFQIKPSENHYSLLT-SQPLDREATSHYIIELLAS 427
Query: 445 DSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINA 502
D+G S +++NI+D N+ AP F YTA + E+ P G+ + V+A+D D G NA
Sbjct: 428 DAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNA 487
Query: 503 QITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
++TYS+ + N+ FV +NP+ G I + D E + + V RD G P L
Sbjct: 488 RLTYSI---VGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPL 544
Query: 562 SDTTDVEISVVDVNDNEPVFK------QQLYTANIMEDALVGTSVSQVGATDADVGLNGR 615
T + + V+D NDN P + + A G+ V++V A DAD G N
Sbjct: 545 HANTSLHVFVLDENDNAPAVLHPRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAW 604
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y L P+ G F++ +G +RT +AL + T + + D G P SST V +
Sbjct: 605 LSYSLLPQSTAPGLFLVSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLL 664
Query: 676 KIEDINDSPPVFESDCL 692
+ED + SD L
Sbjct: 665 VLEDEDPEEMPKSSDFL 681
Score = 214 bits (523), Expect = 3e-54
Identities = 166/578 (28%), Positives = 260/578 (44%), Gaps = 39/578 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT-DKDYTG 303
+ I D+NDN+P F T + +SE+ G A D D G N YT++ + ++
Sbjct: 121 VEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSL 180
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
NV P V QLDRE QA++QL++TA DGG P RS T
Sbjct: 181 NVKTLKDGKPFPELVLEQ-QLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI---TGGNTRGRFSITSQN 418
F V + E+ P GT ++ L ATD DE + +L Y T R F + +
Sbjct: 240 PTFQSSVLRVGIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNLFGLDPSS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G I V P+DF++ R Y + A D G ++Q+++ D N+ AP A
Sbjct: 300 GA--IHVLGPIDFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLAN 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG--AIT 534
V E P+GT V + + D D G N +++ +S ++ F I P ++
Sbjct: 358 PVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISPDLP----------FQIKPSENHYSLL 407
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T++ LDRE S Y++ + A D G PSL + +++ DVNDN P F QQLYTA I+E+
Sbjct: 408 TSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENR 467
Query: 595 LVGTSVSQVGATDADVGLNGRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESV 650
G+ + V A+D D G N R+ Y + + SFV ++P G I + D E +
Sbjct: 468 PPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELL 527
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFE------SDCLTFYISENSPIGT 704
+ D G+PP + +H+ + D ND+ P + ++P G+
Sbjct: 528 QMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAVLHPRPDWEHSAPQRLPRSAPPGS 587
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDS-NSFSLETRQGSDKAELVTMVDLDYESPRKKY 763
+ ++ A D D G NA + YS+ + F + T G + + D +S ++
Sbjct: 588 LVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTHTGEVRTARALLED---DSDTQQV 644
Query: 764 ELVIRAASPPLWNDVRVEILVTDVND--NAPVMKDFQI 799
+++R P + +LV + D P DF I
Sbjct: 645 VVLVRDNGDPSLSSTATVLLVLEDEDPEEMPKSSDFLI 682
Score = 198 bits (483), Expect = 2e-49
Identities = 167/593 (28%), Positives = 266/593 (44%), Gaps = 57/593 (9%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
I ++ +LD ND+SP F + E + E A+SG A D D+G N YT+ +
Sbjct: 117 IRVEVEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNS 176
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASP 125
+LN + DG+ L+ LDRE AR+ +++ A D +P
Sbjct: 177 HFSLNVKTLK----------------DGKPFPELVLEQQLDREAQARHQLVLTAVDGGTP 220
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S T I V ++D NDN P F V + E+ + ++ ++ ATD D G N
Sbjct: 221 AR---SGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPI--GTLLLRLNATDPDEGTNG 275
Query: 186 AIRYAIIGGNT----QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
+ Y+ G +T + F +D SG + ++ +D+E+ R Y + RA+D G P+
Sbjct: 276 QLDYS-FGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARDQGQPAMEGHC 334
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ +++ DVNDNAP + V E+ P+G + D D G N E++ ++
Sbjct: 335 VIQVDVGDVNDNAPEVLLASLANPVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISP--- 391
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
DLP I P + TS LDRE + Y + + A+D G P T
Sbjct: 392 ----DLPFQIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDV 447
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRG--RFSIT 415
F Y + E+ PPG+ + T+ A+D D DN RL Y I G +G S
Sbjct: 448 NDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFV 507
Query: 416 SQNGR-GLITVAQPLDFKQERRYVLTVSATDSGG---RSDTAMVQINITDANNYAP-VFE 470
N G I + D++ + + V DSG ++T++ + + D N+ AP V
Sbjct: 508 YVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSL-HVFVLDENDNAPAVLH 566
Query: 471 NAP---YTA--SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFV 525
P ++A + AP G+ V V+A D+D G NA ++YSL + + + F+
Sbjct: 567 PRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGL------FL 620
Query: 526 INPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNE 578
++ TG + T + L + + V RD G PSLS T V + + D + E
Sbjct: 621 VSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDPEE 673
Score = 132 bits (318), Expect = 2e-29
Identities = 103/329 (31%), Positives = 156/329 (47%), Gaps = 27/329 (8%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E++ GT V V+ D+G+ S ++ +E + + F ++ +GA+ N
Sbjct: 34 SVVEESEPGTLVGNVA---QDLGLKMTDLLSRRLQLGSE---ENGRYFSLSLMSGALAVN 87
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+ +DRE++ G + V + VE+ ++D+NDN P F I E A
Sbjct: 88 QKIDRESLCGASTSCLLPVQVVTEHPLELIRVEVEILDLNDNSPSFATPEREMRISESAA 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVI----DPASGVIRTNKALDRESVA 651
G A D DVG N Y L P + P ++ + LDRE+ A
Sbjct: 148 SGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELV-LEQQLDREAQA 206
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
H L A+DGGTP +S T ++ + + DIND+ P F+S L I EN+PIGT + + A
Sbjct: 207 RHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRLNA 266
Query: 712 HDPDEGPNAVVHYSIKGGDDS-----NSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
DPDEG N + YS GD + N F L+ G+ + + +D+E R YE+
Sbjct: 267 TDPDEGTNGQLDYSF--GDHTSEAVRNLFGLDPSSGA----IHVLGPIDFEESR-FYEIH 319
Query: 767 IRA---ASPPLWNDVRVEILVTDVNDNAP 792
RA P + +++ V DVNDNAP
Sbjct: 320 ARARDQGQPAMEGHCVIQVDVGDVNDNAP 348
>AF152339-1|AAD43733.1| 944|Homo sapiens protocadherin gamma C5
protein.
Length = 944
Score = 252 bits (618), Expect = 1e-65
Identities = 178/617 (28%), Positives = 277/617 (44%), Gaps = 24/617 (3%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SGAL +DRE + + Q V++ + V I+D NDN P
Sbjct: 75 FSLSLMSGALAVNQKIDRESLCGASTSCLLPVQV--VTEHPLELIRVEVEILDLNDNSPS 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F+ + + E S A D DVG N+ Y + N+ ++ +L
Sbjct: 133 FATPEREMRISE--SAASGARFPLDSAQDPDVGTNTVSFYTL-SPNSHFSLNVKTLKDGK 189
Query: 208 ---DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++ L + LD E ++LV+ A DGG+P+RS TT + + + D+NDNAP F +S+ +
Sbjct: 190 PFPELVLEQQLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRV 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
+ EN PIG ++R+ A D DEG N +L Y+ D +L +DP SG ++ G +
Sbjct: 250 GIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNL-FGLDPSSGAIHVLGPI 308
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ A D G P + + E P GT
Sbjct: 309 DFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLANPVLESTPVGTV 368
Query: 385 VVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSAT 444
V D D + S+N L+T +QPLD + Y++ + A+
Sbjct: 369 VGLFNVRDRDSGRNGEVSLDISPDLPFQIKPSENHYSLLT-SQPLDREATSHYIIELLAS 427
Query: 445 DSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINA 502
D+G S +++NI+D N+ AP F YTA + E+ P G+ + V+A+D D G NA
Sbjct: 428 DAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNA 487
Query: 503 QITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
++TYS+ + N+ FV +NP+ G I + D E + + V RD G P L
Sbjct: 488 RLTYSI---VGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPL 544
Query: 562 SDTTDVEISVVDVNDNEPVFK------QQLYTANIMEDALVGTSVSQVGATDADVGLNGR 615
T + + V+D NDN P + + A G+ V++V A DAD G N
Sbjct: 545 HANTSLHVFVLDENDNAPAVLHPRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAW 604
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y L P+ G F++ +G +RT +AL + T + + D G P SST V +
Sbjct: 605 LSYSLLPQSTAPGLFLVSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLL 664
Query: 676 KIEDINDSPPVFESDCL 692
+ED + SD L
Sbjct: 665 VLEDEDPEEMPKSSDFL 681
Score = 214 bits (523), Expect = 3e-54
Identities = 166/578 (28%), Positives = 260/578 (44%), Gaps = 39/578 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT-DKDYTG 303
+ I D+NDN+P F T + +SE+ G A D D G N YT++ + ++
Sbjct: 121 VEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSL 180
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
NV P V QLDRE QA++QL++TA DGG P RS T
Sbjct: 181 NVKTLKDGKPFPELVLEQ-QLDREAQARHQLVLTAVDGGTPARSGTTLISVIVLDINDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI---TGGNTRGRFSITSQN 418
F V + E+ P GT ++ L ATD DE + +L Y T R F + +
Sbjct: 240 PTFQSSVLRVGIPENAPIGTLLLRLNATDPDEGTNGQLDYSFGDHTSEAVRNLFGLDPSS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G I V P+DF++ R Y + A D G ++Q+++ D N+ AP A
Sbjct: 300 GA--IHVLGPIDFEESRFYEIHARARDQGQPAMEGHCVIQVDVGDVNDNAPEVLLASLAN 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG--AIT 534
V E P+GT V + + D D G N +++ +S ++ F I P ++
Sbjct: 358 PVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISPDLP----------FQIKPSENHYSLL 407
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
T++ LDRE S Y++ + A D G PSL + +++ DVNDN P F QQLYTA I+E+
Sbjct: 408 TSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDVNDNAPRFNQQLYTAYILENR 467
Query: 595 LVGTSVSQVGATDADVGLNGRIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESV 650
G+ + V A+D D G N R+ Y + + SFV ++P G I + D E +
Sbjct: 468 PPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFVYVNPEDGRIFAQRTFDYELL 527
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFE------SDCLTFYISENSPIGT 704
+ D G+PP + +H+ + D ND+ P + ++P G+
Sbjct: 528 QMLQIVVGVRDSGSPPLHANTSLHVFVLDENDNAPAVLHPRPDWEHSAPQRLPRSAPPGS 587
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDS-NSFSLETRQGSDKAELVTMVDLDYESPRKKY 763
+ ++ A D D G NA + YS+ + F + T G + + D +S ++
Sbjct: 588 LVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSTHTGEVRTARALLED---DSDTQQV 644
Query: 764 ELVIRAASPPLWNDVRVEILVTDVND--NAPVMKDFQI 799
+++R P + +LV + D P DF I
Sbjct: 645 VVLVRDNGDPSLSSTATVLLVLEDEDPEEMPKSSDFLI 682
Score = 198 bits (483), Expect = 2e-49
Identities = 167/593 (28%), Positives = 266/593 (44%), Gaps = 57/593 (9%)
Query: 7 IHQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
I ++ +LD ND+SP F + E + E A+SG A D D+G N YT+ +
Sbjct: 117 IRVEVEILDLNDNSPSFATPEREMRISESAASGARFPLDSAQDPDVGTNTVSFYTLSPNS 176
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASP 125
+LN + DG+ L+ LDRE AR+ +++ A D +P
Sbjct: 177 HFSLNVKTLK----------------DGKPFPELVLEQQLDREAQARHQLVLTAVDGGTP 220
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
S T I V ++D NDN P F V + E+ + ++ ++ ATD D G N
Sbjct: 221 AR---SGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPI--GTLLLRLNATDPDEGTNG 275
Query: 186 AIRYAIIGGNT----QMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
+ Y+ G +T + F +D SG + ++ +D+E+ R Y + RA+D G P+
Sbjct: 276 QLDYS-FGDHTSEAVRNLFGLDPSSGAIHVLGPIDFEESRFYEIHARARDQGQPAMEGHC 334
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ +++ DVNDNAP + V E+ P+G + D D G N E++ ++
Sbjct: 335 VIQVDVGDVNDNAPEVLLASLANPVLESTPVGTVVGLFNVRDRDSGRNGEVSLDISP--- 391
Query: 302 TGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
DLP I P + TS LDRE + Y + + A+D G P T
Sbjct: 392 ----DLPFQIKPSENHYSLLTSQPLDREATSHYIIELLASDAGSPSLHKHLTIRLNISDV 447
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRG--RFSIT 415
F Y + E+ PPG+ + T+ A+D D DN RL Y I G +G S
Sbjct: 448 NDNAPRFNQQLYTAYILENRPPGSLLCTVAASDPDTGDNARLTYSIVGNQVQGAPASSFV 507
Query: 416 SQNGR-GLITVAQPLDFKQERRYVLTVSATDSGG---RSDTAMVQINITDANNYAP-VFE 470
N G I + D++ + + V DSG ++T++ + + D N+ AP V
Sbjct: 508 YVNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPPLHANTSL-HVFVLDENDNAPAVLH 566
Query: 471 NAP---YTA--SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFV 525
P ++A + AP G+ V V+A D+D G NA ++YSL + + + F+
Sbjct: 567 PRPDWEHSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGL------FL 620
Query: 526 INPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNE 578
++ TG + T + L + + V RD G PSLS T V + + D + E
Sbjct: 621 VSTHTGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDPEE 673
Score = 132 bits (318), Expect = 2e-29
Identities = 103/329 (31%), Positives = 156/329 (47%), Gaps = 27/329 (8%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E++ GT V V+ D+G+ S ++ +E + + F ++ +GA+ N
Sbjct: 34 SVVEESEPGTLVGNVA---QDLGLKMTDLLSRRLQLGSE---ENGRYFSLSLMSGALAVN 87
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+ +DRE++ G + V + VE+ ++D+NDN P F I E A
Sbjct: 88 QKIDRESLCGASTSCLLPVQVVTEHPLELIRVEVEILDLNDNSPSFATPEREMRISESAA 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVI----DPASGVIRTNKALDRESVA 651
G A D DVG N Y L P + P ++ + LDRE+ A
Sbjct: 148 SGARFPLDSAQDPDVGTNTVSFYTLSPNSHFSLNVKTLKDGKPFPELV-LEQQLDREAQA 206
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
H L A+DGGTP +S T ++ + + DIND+ P F+S L I EN+PIGT + + A
Sbjct: 207 RHQLVLTAVDGGTPARSGTTLISVIVLDINDNAPTFQSSVLRVGIPENAPIGTLLLRLNA 266
Query: 712 HDPDEGPNAVVHYSIKGGDDS-----NSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
DPDEG N + YS GD + N F L+ G+ + + +D+E R YE+
Sbjct: 267 TDPDEGTNGQLDYSF--GDHTSEAVRNLFGLDPSSGA----IHVLGPIDFEESR-FYEIH 319
Query: 767 IRA---ASPPLWNDVRVEILVTDVNDNAP 792
RA P + +++ V DVNDNAP
Sbjct: 320 ARARDQGQPAMEGHCVIQVDVGDVNDNAP 348
>BC113607-1|AAI13608.1| 803|Homo sapiens protocadherin gamma
subfamily B, 4 protein.
Length = 803
Score = 251 bits (615), Expect = 2e-65
Identities = 173/605 (28%), Positives = 292/605 (48%), Gaps = 33/605 (5%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAPRFY 258
F++ + SG++ + LD E++ + + + + + N + + I D+ND+ P+F
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFT 134
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
+ F+ +SE+ G + A+DAD G N Y ++ D+ ++ + + +
Sbjct: 135 QNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEM 194
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
LDRE Q Y L +TA D G PP S+TA F Y V L+E+
Sbjct: 195 VLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSEN 254
Query: 379 EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
PGT V+ +TATD DE + + + + + +F + S G ITV LDF++ +
Sbjct: 255 VYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGE--ITVLNTLDFEEVKE 312
Query: 437 YVLTVSATDSGGRSDTAMVQINITDANNYAP--VFENAPYTASVFEDAPIGTTVLVVSAT 494
Y + + A D GG V++ + D N+ AP +F++ P + EDA +GT + ++
Sbjct: 313 YSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSLPNL--IMEDAELGTHIALLKVR 370
Query: 495 DSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
D D N ++T L ++ + + + T + T+ +LDRE Y +TVTA
Sbjct: 371 DKDSRHNGEVTCKLEGDVPFKILTS-------SRNTYKLVTDAVLDREQNPEYNITVTAT 423
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
D G P LS ++ + + + DVNDN PVF Q Y ++ E+ G S+SQV A+D D+G NG
Sbjct: 424 DRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNG 483
Query: 615 RIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
++ Y + D + RE S+V I SGV+ +A D E + +L A D G+P S+
Sbjct: 484 QVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSAN 543
Query: 671 VIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVH 723
V + + ++D ND+ P + L + + G + ++ A D D G NA +
Sbjct: 544 VSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLS 603
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLWNDVRVE 781
Y + + FSL R G E+ T L D ++ R++ + +R PPL +
Sbjct: 604 YHVLQASEPGLFSLGLRTG----EVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLH 659
Query: 782 ILVTD 786
++ D
Sbjct: 660 LVFAD 664
Score = 236 bits (578), Expect = 7e-61
Identities = 182/611 (29%), Positives = 301/611 (49%), Gaps = 42/611 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SG LL + LDRE++ +A V++ + ++V I D ND+ P+
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEA--VAENPLNFYHVNVEIEDINDHTPK 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F++ ++ + + E ++ A DAD+G+N+ Y + + + + G
Sbjct: 133 FTQNSFELQISESAQPGTRFILG--SAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L LD E+ +SY L + A D G+P S+T Q+ + + D NDNAP F +++ S
Sbjct: 191 YPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SENV G ++++V A D DEGVNAE+T++ ++ DL + +G + LD
Sbjct: 251 LSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDL----NSNTGEITVLNTLD 306
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y +++ A DGG T F + ED GT +
Sbjct: 307 FEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQ--SLPNLIMEDAELGTHI 364
Query: 386 VTLTATDADEDNRLHYEIT---GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
L D+D+R + E+T G+ + +S+N L+T A LD +Q Y +TV+
Sbjct: 365 ALLKV--RDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDA-VLDREQNPEYNITVT 421
Query: 443 ATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S ++ + ++I D N+ APVF + Y V E+ P G ++ V A+D D+G
Sbjct: 422 ATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGP 481
Query: 501 NAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
N Q++Y ++S++ ++ + I+ ++G + + D E + + LT+ ARD G P
Sbjct: 482 NGQVSYCIMASDLEQRELSSY---VSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSP 538
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDAD 609
+LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 539 ALSANVSLRVLVDDRNDNAP---RVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDAD 595
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKAL-DRESVATHDLKAVAIDGGTPPQS 668
G N + Y + + E G F + +G +RT +AL DR++V L AV DGG PP S
Sbjct: 596 SGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVR-DGGQPPLS 653
Query: 669 STVIVHIKIED 679
+T +H+ D
Sbjct: 654 ATATLHLVFAD 664
Score = 225 bits (551), Expect = 1e-57
Identities = 168/526 (31%), Positives = 253/526 (48%), Gaps = 30/526 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGRFSITSQNGRGL- 422
F +E++++E PGT + +A DAD N L +Y+++ + + +G
Sbjct: 133 FTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + PLD ++++ Y LT++A D G S TA + + +TDAN+ APVF Y S+
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ GTTVL V+ATD D G+NA+IT+S S A QF +N TG IT L
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSE-------ASQITQFDLNSNTGEITVLNTL 305
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARDGG + VE+ V+D NDN P Q IMEDA +GT
Sbjct: 306 DFEEVKEYSIVLEARDGG--GMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTH 363
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + D D NG + +L+ D + + T+ LDRE +++ A
Sbjct: 364 IALLKVRDKDSRHNGEVTCKLEG-DVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTA 422
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G PP SS+ + + I D+ND+ PVF +++EN+P G +I ++RA DPD GPN
Sbjct: 423 TDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPN 482
Query: 720 AVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLW 775
V Y I D + S ++ + D+E R +EL ++A SP L
Sbjct: 483 GQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRA-FELTLQARDQGSPALS 541
Query: 776 NDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK-- 826
+V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 542 ANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAW 601
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 602 LSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDG 647
Score = 222 bits (543), Expect = 1e-56
Identities = 175/585 (29%), Positives = 277/585 (47%), Gaps = 57/585 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F +E + E A GT + A D DIG N Y
Sbjct: 118 HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPV 126
L+P D + + + DG + ++ + LDREK Y + + A D +P
Sbjct: 171 -QLSPSD--------HFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAP- 220
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
LSSTA IHV + D NDN P FS+ Y VS+ E +V + ++ ATD D G N+
Sbjct: 221 --PLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSE--NVYPGTTVLQVTATDQDEGVNAE 276
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I ++ + QF ++S +G+++++ TLD+E+V+ Y +V+ A+DGG T + +
Sbjct: 277 ITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVE--VE 334
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D NDNAP + E+ +G I ++ D D N E+T + G+V
Sbjct: 335 VIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKL-----EGDVP 389
Query: 307 LPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
I R+ + + T LDRE +Y + VTATD G PP S++++
Sbjct: 390 FKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPV 449
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR-----FSITSQN 418
F Y V +AE+ PPG + + A+D D + ++ Y I + R SI++++
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAES 509
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQIN--ITDANNYAP-VFENA--P 473
G++ + D +Q R + LT+ A D G + +A V + + D N+ AP V A P
Sbjct: 510 --GVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGP 567
Query: 474 YTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++F+ P G V V A D+D G NA ++Y + A F + +
Sbjct: 568 DGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLR 620
Query: 530 TGAITTNKLL-DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T + L DR+ + LL V RDGG P LS T + + D
Sbjct: 621 TGEVRTARALGDRDAVRQRLL-VAVRDGGQPPLSATATLHLVFAD 664
Score = 155 bits (377), Expect = 2e-36
Identities = 114/372 (30%), Positives = 167/372 (44%), Gaps = 14/372 (3%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + I D N++ P F + + E A GT ++ SA D+D+G N Y LS
Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF 178
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ P+ T LDRE Y LT+TA D G P LS T + + V D
Sbjct: 179 SLINKEKSDGSKYPEMVLKTP---LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDA 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN PVF Q +Y ++ E+ GT+V QV ATD D G+N I + + F ++
Sbjct: 236 NDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQIT-QFDLNS 294
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I LD E V + + A DGG TV +++ D ND+ P L
Sbjct: 295 NTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTV--EVEVIDENDNAPEVIFQSLPN 352
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I E++ +GT I ++ D D N V ++G F + T + +LVT L
Sbjct: 353 LIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEG---DVPFKILT-SSRNTYKLVTDAVL 408
Query: 755 DYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E +Y + + A PPL + + + + DVNDNAPV I + ++ P
Sbjct: 409 DREQ-NPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGA 467
Query: 812 PFGRVPAYDADV 823
+V A D D+
Sbjct: 468 SISQVRASDPDL 479
Score = 149 bits (361), Expect = 1e-34
Identities = 134/480 (27%), Positives = 214/480 (44%), Gaps = 46/480 (9%)
Query: 4 PFCIHQQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
P QI+VL D ND++PVF Y S+ E GTTVL + ATDQD G NAE+ ++
Sbjct: 221 PLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFS 280
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
+ T F ++ +G + +LD E+V Y+++++A D
Sbjct: 281 FSEASQIT-------------------QFDLNSNTGEITVLNTLDFEEVKEYSIVLEARD 321
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
++ T+ V +ID+NDN P+ ++ + ED + + IA +K D D
Sbjct: 322 GGGMIAQ-----CTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTH--IALLKVRDKDS 374
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRS 238
N + + G + F I + S + + T LD EQ Y + + A D G P S
Sbjct: 375 RHNGEVTCKLEG---DVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLS 431
Query: 239 NTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD 298
+++ + ++I DVNDNAP F S + V+EN P G SI +V+A D D G N +++Y +
Sbjct: 432 SSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMA 491
Query: 299 KDY-TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
D + ++I SG V+ D E ++L + A D G P SA +
Sbjct: 492 SDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVD 551
Query: 358 XXXXXXXXFM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNT 408
+ P G L + P PG V + A DAD + L Y + +
Sbjct: 552 DRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASE 611
Query: 409 RGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G FS+ + G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 612 PGLFSLGLRTGE--VRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 669
Score = 98.7 bits (235), Expect = 3e-19
Identities = 77/271 (28%), Positives = 121/271 (44%), Gaps = 10/271 (3%)
Query: 626 EEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI--KIEDINDS 683
E+ F + SG + + LDRE + A A++ ++ H+ +IEDIND
Sbjct: 71 EKPYFTVSAESGELLVSSRLDREEICGKK-PACALEFEAVAENPLNFYHVNVEIEDINDH 129
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
P F + ISE++ GT AHD D G N + +Y + D + + E GS
Sbjct: 130 TPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGS 189
Query: 744 DKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQII 800
E+V LD E +K Y L + A +PPL + ++ +LVTD NDNAPV
Sbjct: 190 KYPEMVLKTPLDREK-QKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYR 248
Query: 801 FNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTN 858
+ ++ +P +V A D D V ++ + + LN TG +T+ L+
Sbjct: 249 VSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE 308
Query: 859 VPKLATMEVSVTDGVNEIKAMMQLSVRLITE 889
K ++ + DG I A + V +I E
Sbjct: 309 EVKEYSIVLEARDGGGMI-AQCTVEVEVIDE 338
>BC112088-1|AAI12089.1| 803|Homo sapiens protocadherin gamma
subfamily B, 4, isoform 2 precursor protein.
Length = 803
Score = 251 bits (615), Expect = 2e-65
Identities = 173/605 (28%), Positives = 292/605 (48%), Gaps = 33/605 (5%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAPRFY 258
F++ + SG++ + LD E++ + + + + + N + + I D+ND+ P+F
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFT 134
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
+ F+ +SE+ G + A+DAD G N Y ++ D+ ++ + + +
Sbjct: 135 QNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEM 194
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
LDRE Q Y L +TA D G PP S+TA F Y V L+E+
Sbjct: 195 VLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSEN 254
Query: 379 EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
PGT V+ +TATD DE + + + + + +F + S G ITV LDF++ +
Sbjct: 255 VYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGE--ITVLNTLDFEEVKE 312
Query: 437 YVLTVSATDSGGRSDTAMVQINITDANNYAP--VFENAPYTASVFEDAPIGTTVLVVSAT 494
Y + + A D GG V++ + D N+ AP +F++ P + EDA +GT + ++
Sbjct: 313 YSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSLPNL--IMEDAELGTHIALLKVR 370
Query: 495 DSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
D D N ++T L ++ + + + T + T+ +LDRE Y +TVTA
Sbjct: 371 DKDSRHNGEVTCKLEGDVPFKILTS-------SRNTYKLVTDAVLDREQNPEYNITVTAT 423
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
D G P LS ++ + + + DVNDN PVF Q Y ++ E+ G S+SQV A+D D+G NG
Sbjct: 424 DRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNG 483
Query: 615 RIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
++ Y + D + RE S+V I SGV+ +A D E + +L A D G+P S+
Sbjct: 484 QVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSAN 543
Query: 671 VIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVH 723
V + + ++D ND+ P + L + + G + ++ A D D G NA +
Sbjct: 544 VSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLS 603
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLWNDVRVE 781
Y + + FSL R G E+ T L D ++ R++ + +R PPL +
Sbjct: 604 YHVLQASEPGLFSLGLRTG----EVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLH 659
Query: 782 ILVTD 786
++ D
Sbjct: 660 LVFAD 664
Score = 236 bits (578), Expect = 7e-61
Identities = 182/611 (29%), Positives = 301/611 (49%), Gaps = 42/611 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SG LL + LDRE++ +A V++ + ++V I D ND+ P+
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEA--VAENPLNFYHVNVEIEDINDHTPK 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F++ ++ + + E ++ A DAD+G+N+ Y + + + + G
Sbjct: 133 FTQNSFELQISESAQPGTRFILG--SAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L LD E+ +SY L + A D G+P S+T Q+ + + D NDNAP F +++ S
Sbjct: 191 YPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SENV G ++++V A D DEGVNAE+T++ ++ DL + +G + LD
Sbjct: 251 LSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDL----NSNTGEITVLNTLD 306
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y +++ A DGG T F + ED GT +
Sbjct: 307 FEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQ--SLPNLIMEDAELGTHI 364
Query: 386 VTLTATDADEDNRLHYEIT---GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
L D+D+R + E+T G+ + +S+N L+T A LD +Q Y +TV+
Sbjct: 365 ALLKV--RDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDA-VLDREQNPEYNITVT 421
Query: 443 ATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S ++ + ++I D N+ APVF + Y V E+ P G ++ V A+D D+G
Sbjct: 422 ATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGP 481
Query: 501 NAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
N Q++Y ++S++ ++ + I+ ++G + + D E + + LT+ ARD G P
Sbjct: 482 NGQVSYCIMASDLEQRELSSY---VSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSP 538
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDAD 609
+LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 539 ALSANVSLRVLVDDRNDNAP---RVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDAD 595
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKAL-DRESVATHDLKAVAIDGGTPPQS 668
G N + Y + + E G F + +G +RT +AL DR++V L AV DGG PP S
Sbjct: 596 SGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVR-DGGQPPLS 653
Query: 669 STVIVHIKIED 679
+T +H+ D
Sbjct: 654 ATATLHLVFAD 664
Score = 225 bits (551), Expect = 1e-57
Identities = 168/526 (31%), Positives = 253/526 (48%), Gaps = 30/526 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGRFSITSQNGRGL- 422
F +E++++E PGT + +A DAD N L +Y+++ + + +G
Sbjct: 133 FTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + PLD ++++ Y LT++A D G S TA + + +TDAN+ APVF Y S+
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ GTTVL V+ATD D G+NA+IT+S S A QF +N TG IT L
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSE-------ASQITQFDLNSNTGEITVLNTL 305
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARDGG + VE+ V+D NDN P Q IMEDA +GT
Sbjct: 306 DFEEVKEYSIVLEARDGG--GMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTH 363
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + D D NG + +L+ D + + T+ LDRE +++ A
Sbjct: 364 IALLKVRDKDSRHNGEVTCKLEG-DVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTA 422
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G PP SS+ + + I D+ND+ PVF +++EN+P G +I ++RA DPD GPN
Sbjct: 423 TDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPN 482
Query: 720 AVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLW 775
V Y I D + S ++ + D+E R +EL ++A SP L
Sbjct: 483 GQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRA-FELTLQARDQGSPALS 541
Query: 776 NDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK-- 826
+V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 542 ANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAW 601
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 602 LSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDG 647
Score = 222 bits (543), Expect = 1e-56
Identities = 175/585 (29%), Positives = 277/585 (47%), Gaps = 57/585 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F +E + E A GT + A D DIG N Y
Sbjct: 118 HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPV 126
L+P D + + + DG + ++ + LDREK Y + + A D +P
Sbjct: 171 -QLSPSD--------HFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAP- 220
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
LSSTA IHV + D NDN P FS+ Y VS+ E +V + ++ ATD D G N+
Sbjct: 221 --PLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSE--NVYPGTTVLQVTATDQDEGVNAE 276
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I ++ + QF ++S +G+++++ TLD+E+V+ Y +V+ A+DGG T + +
Sbjct: 277 ITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVE--VE 334
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D NDNAP + E+ +G I ++ D D N E+T + G+V
Sbjct: 335 VIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKL-----EGDVP 389
Query: 307 LPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
I R+ + + T LDRE +Y + VTATD G PP S++++
Sbjct: 390 FKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPV 449
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR-----FSITSQN 418
F Y V +AE+ PPG + + A+D D + ++ Y I + R SI++++
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAES 509
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQIN--ITDANNYAP-VFENA--P 473
G++ + D +Q R + LT+ A D G + +A V + + D N+ AP V A P
Sbjct: 510 --GVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGP 567
Query: 474 YTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++F+ P G V V A D+D G NA ++Y + A F + +
Sbjct: 568 DGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLR 620
Query: 530 TGAITTNKLL-DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T + L DR+ + LL V RDGG P LS T + + D
Sbjct: 621 TGEVRTARALGDRDAVRQRLL-VAVRDGGQPPLSATATLHLVFAD 664
Score = 155 bits (377), Expect = 2e-36
Identities = 114/372 (30%), Positives = 167/372 (44%), Gaps = 14/372 (3%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + I D N++ P F + + E A GT ++ SA D+D+G N Y LS
Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF 178
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ P+ T LDRE Y LT+TA D G P LS T + + V D
Sbjct: 179 SLINKEKSDGSKYPEMVLKTP---LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDA 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN PVF Q +Y ++ E+ GT+V QV ATD D G+N I + + F ++
Sbjct: 236 NDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQIT-QFDLNS 294
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I LD E V + + A DGG TV +++ D ND+ P L
Sbjct: 295 NTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTV--EVEVIDENDNAPEVIFQSLPN 352
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I E++ +GT I ++ D D N V ++G F + T + +LVT L
Sbjct: 353 LIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEG---DVPFKILT-SSRNTYKLVTDAVL 408
Query: 755 DYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E +Y + + A PPL + + + + DVNDNAPV I + ++ P
Sbjct: 409 DREQ-NPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGA 467
Query: 812 PFGRVPAYDADV 823
+V A D D+
Sbjct: 468 SISQVRASDPDL 479
Score = 149 bits (361), Expect = 1e-34
Identities = 134/480 (27%), Positives = 214/480 (44%), Gaps = 46/480 (9%)
Query: 4 PFCIHQQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
P QI+VL D ND++PVF Y S+ E GTTVL + ATDQD G NAE+ ++
Sbjct: 221 PLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFS 280
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
+ T F ++ +G + +LD E+V Y+++++A D
Sbjct: 281 FSEASQIT-------------------QFDLNSNTGEITVLNTLDFEEVKEYSIVLEARD 321
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
++ T+ V +ID+NDN P+ ++ + ED + + IA +K D D
Sbjct: 322 GGGMIAQ-----CTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTH--IALLKVRDKDS 374
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRS 238
N + + G + F I + S + + T LD EQ Y + + A D G P S
Sbjct: 375 RHNGEVTCKLEG---DVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLS 431
Query: 239 NTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD 298
+++ + ++I DVNDNAP F S + V+EN P G SI +V+A D D G N +++Y +
Sbjct: 432 SSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMA 491
Query: 299 KDY-TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
D + ++I SG V+ D E ++L + A D G P SA +
Sbjct: 492 SDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVD 551
Query: 358 XXXXXXXXFM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNT 408
+ P G L + P PG V + A DAD + L Y + +
Sbjct: 552 DRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASE 611
Query: 409 RGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G FS+ + G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 612 PGLFSLGLRTGE--VRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 669
Score = 98.7 bits (235), Expect = 3e-19
Identities = 77/271 (28%), Positives = 121/271 (44%), Gaps = 10/271 (3%)
Query: 626 EEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI--KIEDINDS 683
E+ F + SG + + LDRE + A A++ ++ H+ +IEDIND
Sbjct: 71 EKPYFTVSAESGELLVSSRLDREEICGKK-PACALEFEAVAENPLNFYHVNVEIEDINDH 129
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
P F + ISE++ GT AHD D G N + +Y + D + + E GS
Sbjct: 130 TPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGS 189
Query: 744 DKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQII 800
E+V LD E +K Y L + A +PPL + ++ +LVTD NDNAPV
Sbjct: 190 KYPEMVLKTPLDREK-QKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYR 248
Query: 801 FNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTN 858
+ ++ +P +V A D D V ++ + + LN TG +T+ L+
Sbjct: 249 VSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE 308
Query: 859 VPKLATMEVSVTDGVNEIKAMMQLSVRLITE 889
K ++ + DG I A + V +I E
Sbjct: 309 EVKEYSIVLEARDGGGMI-AQCTVEVEVIDE 338
>AF152520-1|AAD43780.1| 803|Homo sapiens protocadherin gamma B4
short form protein protein.
Length = 803
Score = 251 bits (615), Expect = 2e-65
Identities = 173/605 (28%), Positives = 292/605 (48%), Gaps = 33/605 (5%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAPRFY 258
F++ + SG++ + LD E++ + + + + + N + + I D+ND+ P+F
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFT 134
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
+ F+ +SE+ G + A+DAD G N Y ++ D+ ++ + + +
Sbjct: 135 QNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEM 194
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
LDRE Q Y L +TA D G PP S+TA F Y V L+E+
Sbjct: 195 VLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSEN 254
Query: 379 EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
PGT V+ +TATD DE + + + + + +F + S G ITV LDF++ +
Sbjct: 255 VYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGE--ITVLNTLDFEEVKE 312
Query: 437 YVLTVSATDSGGRSDTAMVQINITDANNYAP--VFENAPYTASVFEDAPIGTTVLVVSAT 494
Y + + A D GG V++ + D N+ AP +F++ P + EDA +GT + ++
Sbjct: 313 YSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSLPNL--IMEDAELGTHIALLKVR 370
Query: 495 DSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
D D N ++T L ++ + + + T + T+ +LDRE Y +TVTA
Sbjct: 371 DKDSRHNGEVTCKLEGDVPFKILTS-------SRNTYKLVTDAVLDREQNPEYNITVTAT 423
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
D G P LS ++ + + + DVNDN PVF Q Y ++ E+ G S+SQV A+D D+G NG
Sbjct: 424 DRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNG 483
Query: 615 RIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
++ Y + D + RE S+V I SGV+ +A D E + +L A D G+P S+
Sbjct: 484 QVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSAN 543
Query: 671 VIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVH 723
V + + ++D ND+ P + L + + G + ++ A D D G NA +
Sbjct: 544 VSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLS 603
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLWNDVRVE 781
Y + + FSL R G E+ T L D ++ R++ + +R PPL +
Sbjct: 604 YHVLQASEPGLFSLGLRTG----EVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLH 659
Query: 782 ILVTD 786
++ D
Sbjct: 660 LVFAD 664
Score = 236 bits (578), Expect = 7e-61
Identities = 182/611 (29%), Positives = 301/611 (49%), Gaps = 42/611 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SG LL + LDRE++ +A V++ + ++V I D ND+ P+
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEA--VAENPLNFYHVNVEIEDINDHTPK 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F++ ++ + + E ++ A DAD+G+N+ Y + + + + G
Sbjct: 133 FTQNSFELQISESAQPGTRFILG--SAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L LD E+ +SY L + A D G+P S+T Q+ + + D NDNAP F +++ S
Sbjct: 191 YPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SENV G ++++V A D DEGVNAE+T++ ++ DL + +G + LD
Sbjct: 251 LSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDL----NSNTGEITVLNTLD 306
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y +++ A DGG T F + ED GT +
Sbjct: 307 FEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQ--SLPNLIMEDAELGTHI 364
Query: 386 VTLTATDADEDNRLHYEIT---GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
L D+D+R + E+T G+ + +S+N L+T A LD +Q Y +TV+
Sbjct: 365 ALLKV--RDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDA-VLDREQNPEYNITVT 421
Query: 443 ATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S ++ + ++I D N+ APVF + Y V E+ P G ++ V A+D D+G
Sbjct: 422 ATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGP 481
Query: 501 NAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
N Q++Y ++S++ ++ + I+ ++G + + D E + + LT+ ARD G P
Sbjct: 482 NGQVSYCIMASDLEQRELSSY---VSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSP 538
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDAD 609
+LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 539 ALSANVSLRVLVDDRNDNAP---RVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDAD 595
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKAL-DRESVATHDLKAVAIDGGTPPQS 668
G N + Y + + E G F + +G +RT +AL DR++V L AV DGG PP S
Sbjct: 596 SGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVR-DGGQPPLS 653
Query: 669 STVIVHIKIED 679
+T +H+ D
Sbjct: 654 ATATLHLVFAD 664
Score = 225 bits (551), Expect = 1e-57
Identities = 168/526 (31%), Positives = 253/526 (48%), Gaps = 30/526 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGRFSITSQNGRGL- 422
F +E++++E PGT + +A DAD N L +Y+++ + + +G
Sbjct: 133 FTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + PLD ++++ Y LT++A D G S TA + + +TDAN+ APVF Y S+
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ GTTVL V+ATD D G+NA+IT+S S A QF +N TG IT L
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSE-------ASQITQFDLNSNTGEITVLNTL 305
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARDGG + VE+ V+D NDN P Q IMEDA +GT
Sbjct: 306 DFEEVKEYSIVLEARDGG--GMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTH 363
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + D D NG + +L+ D + + T+ LDRE +++ A
Sbjct: 364 IALLKVRDKDSRHNGEVTCKLEG-DVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTA 422
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G PP SS+ + + I D+ND+ PVF +++EN+P G +I ++RA DPD GPN
Sbjct: 423 TDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPN 482
Query: 720 AVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLW 775
V Y I D + S ++ + D+E R +EL ++A SP L
Sbjct: 483 GQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRA-FELTLQARDQGSPALS 541
Query: 776 NDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK-- 826
+V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 542 ANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAW 601
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 602 LSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDG 647
Score = 222 bits (543), Expect = 1e-56
Identities = 175/585 (29%), Positives = 277/585 (47%), Gaps = 57/585 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F +E + E A GT + A D DIG N Y
Sbjct: 118 HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPV 126
L+P D + + + DG + ++ + LDREK Y + + A D +P
Sbjct: 171 -QLSPSD--------HFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAP- 220
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
LSSTA IHV + D NDN P FS+ Y VS+ E +V + ++ ATD D G N+
Sbjct: 221 --PLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSE--NVYPGTTVLQVTATDQDEGVNAE 276
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I ++ + QF ++S +G+++++ TLD+E+V+ Y +V+ A+DGG T + +
Sbjct: 277 ITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVE--VE 334
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D NDNAP + E+ +G I ++ D D N E+T + G+V
Sbjct: 335 VIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKL-----EGDVP 389
Query: 307 LPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
I R+ + + T LDRE +Y + VTATD G PP S++++
Sbjct: 390 FKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPV 449
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR-----FSITSQN 418
F Y V +AE+ PPG + + A+D D + ++ Y I + R SI++++
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAES 509
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQIN--ITDANNYAP-VFENA--P 473
G++ + D +Q R + LT+ A D G + +A V + + D N+ AP V A P
Sbjct: 510 --GVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGP 567
Query: 474 YTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++F+ P G V V A D+D G NA ++Y + A F + +
Sbjct: 568 DGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLR 620
Query: 530 TGAITTNKLL-DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T + L DR+ + LL V RDGG P LS T + + D
Sbjct: 621 TGEVRTARALGDRDAVRQRLL-VAVRDGGQPPLSATATLHLVFAD 664
Score = 155 bits (377), Expect = 2e-36
Identities = 114/372 (30%), Positives = 167/372 (44%), Gaps = 14/372 (3%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + I D N++ P F + + E A GT ++ SA D+D+G N Y LS
Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF 178
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ P+ T LDRE Y LT+TA D G P LS T + + V D
Sbjct: 179 SLINKEKSDGSKYPEMVLKTP---LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDA 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN PVF Q +Y ++ E+ GT+V QV ATD D G+N I + + F ++
Sbjct: 236 NDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQIT-QFDLNS 294
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I LD E V + + A DGG TV +++ D ND+ P L
Sbjct: 295 NTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTV--EVEVIDENDNAPEVIFQSLPN 352
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I E++ +GT I ++ D D N V ++G F + T + +LVT L
Sbjct: 353 LIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEG---DVPFKILT-SSRNTYKLVTDAVL 408
Query: 755 DYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E +Y + + A PPL + + + + DVNDNAPV I + ++ P
Sbjct: 409 DREQ-NPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGA 467
Query: 812 PFGRVPAYDADV 823
+V A D D+
Sbjct: 468 SISQVRASDPDL 479
Score = 149 bits (361), Expect = 1e-34
Identities = 134/480 (27%), Positives = 214/480 (44%), Gaps = 46/480 (9%)
Query: 4 PFCIHQQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
P QI+VL D ND++PVF Y S+ E GTTVL + ATDQD G NAE+ ++
Sbjct: 221 PLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFS 280
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
+ T F ++ +G + +LD E+V Y+++++A D
Sbjct: 281 FSEASQIT-------------------QFDLNSNTGEITVLNTLDFEEVKEYSIVLEARD 321
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
++ T+ V +ID+NDN P+ ++ + ED + + IA +K D D
Sbjct: 322 GGGMIAQ-----CTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTH--IALLKVRDKDS 374
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRS 238
N + + G + F I + S + + T LD EQ Y + + A D G P S
Sbjct: 375 RHNGEVTCKLEG---DVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLS 431
Query: 239 NTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD 298
+++ + ++I DVNDNAP F S + V+EN P G SI +V+A D D G N +++Y +
Sbjct: 432 SSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMA 491
Query: 299 KDY-TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
D + ++I SG V+ D E ++L + A D G P SA +
Sbjct: 492 SDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVD 551
Query: 358 XXXXXXXXFM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNT 408
+ P G L + P PG V + A DAD + L Y + +
Sbjct: 552 DRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASE 611
Query: 409 RGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G FS+ + G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 612 PGLFSLGLRTGE--VRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 669
Score = 98.7 bits (235), Expect = 3e-19
Identities = 77/271 (28%), Positives = 121/271 (44%), Gaps = 10/271 (3%)
Query: 626 EEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI--KIEDINDS 683
E+ F + SG + + LDRE + A A++ ++ H+ +IEDIND
Sbjct: 71 EKPYFTVSAESGELLVSSRLDREEICGKK-PACALEFEAVAENPLNFYHVNVEIEDINDH 129
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
P F + ISE++ GT AHD D G N + +Y + D + + E GS
Sbjct: 130 TPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGS 189
Query: 744 DKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQII 800
E+V LD E +K Y L + A +PPL + ++ +LVTD NDNAPV
Sbjct: 190 KYPEMVLKTPLDREK-QKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYR 248
Query: 801 FNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTN 858
+ ++ +P +V A D D V ++ + + LN TG +T+ L+
Sbjct: 249 VSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE 308
Query: 859 VPKLATMEVSVTDGVNEIKAMMQLSVRLITE 889
K ++ + DG I A + V +I E
Sbjct: 309 EVKEYSIVLEARDGGGMI-AQCTVEVEVIDE 338
>AF152333-1|AAD43727.1| 923|Homo sapiens protocadherin gamma B4
protein.
Length = 923
Score = 251 bits (615), Expect = 2e-65
Identities = 173/605 (28%), Positives = 292/605 (48%), Gaps = 33/605 (5%)
Query: 200 FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQ-DGGSPSRSNTTQLLINIRDVNDNAPRFY 258
F++ + SG++ + LD E++ + + + + + N + + I D+ND+ P+F
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFT 134
Query: 259 TSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWV 318
+ F+ +SE+ G + A+DAD G N Y ++ D+ ++ + + +
Sbjct: 135 QNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEM 194
Query: 319 YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAED 378
LDRE Q Y L +TA D G PP S+TA F Y V L+E+
Sbjct: 195 VLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSEN 254
Query: 379 EPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERR 436
PGT V+ +TATD DE + + + + + +F + S G ITV LDF++ +
Sbjct: 255 VYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGE--ITVLNTLDFEEVKE 312
Query: 437 YVLTVSATDSGGRSDTAMVQINITDANNYAP--VFENAPYTASVFEDAPIGTTVLVVSAT 494
Y + + A D GG V++ + D N+ AP +F++ P + EDA +GT + ++
Sbjct: 313 YSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSLPNL--IMEDAELGTHIALLKVR 370
Query: 495 DSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
D D N ++T L ++ + + + T + T+ +LDRE Y +TVTA
Sbjct: 371 DKDSRHNGEVTCKLEGDVPFKILTS-------SRNTYKLVTDAVLDREQNPEYNITVTAT 423
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG 614
D G P LS ++ + + + DVNDN PVF Q Y ++ E+ G S+SQV A+D D+G NG
Sbjct: 424 DRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNG 483
Query: 615 RIHYEL---DPKDREEGSFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
++ Y + D + RE S+V I SGV+ +A D E + +L A D G+P S+
Sbjct: 484 QVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSAN 543
Query: 671 VIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVH 723
V + + ++D ND+ P + L + + G + ++ A D D G NA +
Sbjct: 544 VSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLS 603
Query: 724 YSIKGGDDSNSFSLETRQGSDKAELVTMVDL-DYESPRKKYELVIR-AASPPLWNDVRVE 781
Y + + FSL R G E+ T L D ++ R++ + +R PPL +
Sbjct: 604 YHVLQASEPGLFSLGLRTG----EVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLH 659
Query: 782 ILVTD 786
++ D
Sbjct: 660 LVFAD 664
Score = 236 bits (578), Expect = 7e-61
Identities = 182/611 (29%), Positives = 301/611 (49%), Gaps = 42/611 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SG LL + LDRE++ +A V++ + ++V I D ND+ P+
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEA--VAENPLNFYHVNVEIEDINDHTPK 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F++ ++ + + E ++ A DAD+G+N+ Y + + + + G
Sbjct: 133 FTQNSFELQISESAQPGTRFILG--SAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L LD E+ +SY L + A D G+P S+T Q+ + + D NDNAP F +++ S
Sbjct: 191 YPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SENV G ++++V A D DEGVNAE+T++ ++ DL + +G + LD
Sbjct: 251 LSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDL----NSNTGEITVLNTLD 306
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y +++ A DGG T F + ED GT +
Sbjct: 307 FEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQ--SLPNLIMEDAELGTHI 364
Query: 386 VTLTATDADEDNRLHYEIT---GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
L D+D+R + E+T G+ + +S+N L+T A LD +Q Y +TV+
Sbjct: 365 ALLKV--RDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDA-VLDREQNPEYNITVT 421
Query: 443 ATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S ++ + ++I D N+ APVF + Y V E+ P G ++ V A+D D+G
Sbjct: 422 ATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGP 481
Query: 501 NAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
N Q++Y ++S++ ++ + I+ ++G + + D E + + LT+ ARD G P
Sbjct: 482 NGQVSYCIMASDLEQRELSSY---VSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSP 538
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDAD 609
+LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 539 ALSANVSLRVLVDDRNDNAP---RVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDAD 595
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKAL-DRESVATHDLKAVAIDGGTPPQS 668
G N + Y + + E G F + +G +RT +AL DR++V L AV DGG PP S
Sbjct: 596 SGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVR-DGGQPPLS 653
Query: 669 STVIVHIKIED 679
+T +H+ D
Sbjct: 654 ATATLHLVFAD 664
Score = 225 bits (551), Expect = 1e-57
Identities = 168/526 (31%), Positives = 253/526 (48%), Gaps = 30/526 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGRFSITSQNGRGL- 422
F +E++++E PGT + +A DAD N L +Y+++ + + +G
Sbjct: 133 FTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + PLD ++++ Y LT++A D G S TA + + +TDAN+ APVF Y S+
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ GTTVL V+ATD D G+NA+IT+S S A QF +N TG IT L
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSE-------ASQITQFDLNSNTGEITVLNTL 305
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARDGG + VE+ V+D NDN P Q IMEDA +GT
Sbjct: 306 DFEEVKEYSIVLEARDGG--GMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTH 363
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + D D NG + +L+ D + + T+ LDRE +++ A
Sbjct: 364 IALLKVRDKDSRHNGEVTCKLEG-DVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTA 422
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G PP SS+ + + I D+ND+ PVF +++EN+P G +I ++RA DPD GPN
Sbjct: 423 TDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPN 482
Query: 720 AVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLW 775
V Y I D + S ++ + D+E R +EL ++A SP L
Sbjct: 483 GQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRA-FELTLQARDQGSPALS 541
Query: 776 NDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK-- 826
+V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 542 ANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAW 601
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 602 LSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDG 647
Score = 222 bits (543), Expect = 1e-56
Identities = 175/585 (29%), Positives = 277/585 (47%), Gaps = 57/585 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F +E + E A GT + A D DIG N Y
Sbjct: 118 HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPV 126
L+P D + + + DG + ++ + LDREK Y + + A D +P
Sbjct: 171 -QLSPSD--------HFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAP- 220
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
LSSTA IHV + D NDN P FS+ Y VS+ E +V + ++ ATD D G N+
Sbjct: 221 --PLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSE--NVYPGTTVLQVTATDQDEGVNAE 276
Query: 187 IRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I ++ + QF ++S +G+++++ TLD+E+V+ Y +V+ A+DGG T + +
Sbjct: 277 ITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVE--VE 334
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D NDNAP + E+ +G I ++ D D N E+T + G+V
Sbjct: 335 VIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKL-----EGDVP 389
Query: 307 LPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
I R+ + + T LDRE +Y + VTATD G PP S++++
Sbjct: 390 FKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPV 449
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR-----FSITSQN 418
F Y V +AE+ PPG + + A+D D + ++ Y I + R SI++++
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAES 509
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQIN--ITDANNYAP-VFENA--P 473
G++ + D +Q R + LT+ A D G + +A V + + D N+ AP V A P
Sbjct: 510 --GVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGP 567
Query: 474 YTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++F+ P G V V A D+D G NA ++Y + A F + +
Sbjct: 568 DGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLR 620
Query: 530 TGAITTNKLL-DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T + L DR+ + LL V RDGG P LS T + + D
Sbjct: 621 TGEVRTARALGDRDAVRQRLL-VAVRDGGQPPLSATATLHLVFAD 664
Score = 155 bits (377), Expect = 2e-36
Identities = 114/372 (30%), Positives = 167/372 (44%), Gaps = 14/372 (3%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + I D N++ P F + + E A GT ++ SA D+D+G N Y LS
Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF 178
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ P+ T LDRE Y LT+TA D G P LS T + + V D
Sbjct: 179 SLINKEKSDGSKYPEMVLKTP---LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDA 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN PVF Q +Y ++ E+ GT+V QV ATD D G+N I + + F ++
Sbjct: 236 NDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQIT-QFDLNS 294
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I LD E V + + A DGG TV +++ D ND+ P L
Sbjct: 295 NTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTV--EVEVIDENDNAPEVIFQSLPN 352
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I E++ +GT I ++ D D N V ++G F + T + +LVT L
Sbjct: 353 LIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEG---DVPFKILT-SSRNTYKLVTDAVL 408
Query: 755 DYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E +Y + + A PPL + + + + DVNDNAPV I + ++ P
Sbjct: 409 DREQ-NPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGA 467
Query: 812 PFGRVPAYDADV 823
+V A D D+
Sbjct: 468 SISQVRASDPDL 479
Score = 149 bits (361), Expect = 1e-34
Identities = 134/480 (27%), Positives = 214/480 (44%), Gaps = 46/480 (9%)
Query: 4 PFCIHQQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
P QI+VL D ND++PVF Y S+ E GTTVL + ATDQD G NAE+ ++
Sbjct: 221 PLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFS 280
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
+ T F ++ +G + +LD E+V Y+++++A D
Sbjct: 281 FSEASQIT-------------------QFDLNSNTGEITVLNTLDFEEVKEYSIVLEARD 321
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
++ T+ V +ID+NDN P+ ++ + ED + + IA +K D D
Sbjct: 322 GGGMIAQ-----CTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTH--IALLKVRDKDS 374
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRS 238
N + + G + F I + S + + T LD EQ Y + + A D G P S
Sbjct: 375 RHNGEVTCKLEG---DVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLS 431
Query: 239 NTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD 298
+++ + ++I DVNDNAP F S + V+EN P G SI +V+A D D G N +++Y +
Sbjct: 432 SSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMA 491
Query: 299 KDY-TGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
D + ++I SG V+ D E ++L + A D G P SA +
Sbjct: 492 SDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVD 551
Query: 358 XXXXXXXXFM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNT 408
+ P G L + P PG V + A DAD + L Y + +
Sbjct: 552 DRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASE 611
Query: 409 RGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G FS+ + G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 612 PGLFSLGLRTGE--VRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 669
Score = 98.7 bits (235), Expect = 3e-19
Identities = 77/271 (28%), Positives = 121/271 (44%), Gaps = 10/271 (3%)
Query: 626 EEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI--KIEDINDS 683
E+ F + SG + + LDRE + A A++ ++ H+ +IEDIND
Sbjct: 71 EKPYFTVSAESGELLVSSRLDREEICGKK-PACALEFEAVAENPLNFYHVNVEIEDINDH 129
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGS 743
P F + ISE++ GT AHD D G N + +Y + D + + E GS
Sbjct: 130 TPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGS 189
Query: 744 DKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQII 800
E+V LD E +K Y L + A +PPL + ++ +LVTD NDNAPV
Sbjct: 190 KYPEMVLKTPLDREK-QKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYR 248
Query: 801 FNNYKDCFPVGPFGRVPAYDAD--VTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTN 858
+ ++ +P +V A D D V ++ + + LN TG +T+ L+
Sbjct: 249 VSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE 308
Query: 859 VPKLATMEVSVTDGVNEIKAMMQLSVRLITE 889
K ++ + DG I A + V +I E
Sbjct: 309 EVKEYSIVLEARDGGGMI-AQCTVEVEVIDE 338
>BC093879-1|AAH93879.1| 818|Homo sapiens protocadherin gamma
subfamily B, 5 protein.
Length = 818
Score = 250 bits (613), Expect = 4e-65
Identities = 187/609 (30%), Positives = 302/609 (49%), Gaps = 40/609 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SG LL + LDRE++ +A V++ + ++V I D ND+ P+
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEA--VAENPLNFYHVNVEIEDINDHTPK 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F++ ++ + + E ++ A DAD+G NS +Y + + + G
Sbjct: 133 FTQNSFELQISESAQPGTRFILEV--AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
+++L KTLD EQ +RLV+ A DGG P S TT+L I + D NDN P F +++ S
Sbjct: 191 YPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ ENVP G ++++V A D DEG+N+E+TY+ TG + +++ +SG + T +LD
Sbjct: 251 LRENVPPGTTVLQVSATDQDEGINSEITYSFY---RTGQI---FSLNSKSGEITTQKKLD 304
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y ++V DGG T F E+ + E+ PGT +
Sbjct: 305 FEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTF-HSLLEM-ILENAVPGTLI 362
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ D D E+ ++ ++ G + +S+N L+T LD +Q Y +T++A
Sbjct: 363 ALIKIHDQDSGENGEVNCQLQ-GEVPFKIISSSKNSYKLVTDG-TLDREQTPEYNVTITA 420
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G S + V ++I D N+ APVF A Y SV E+ P G ++ V A+D D+G+N
Sbjct: 421 TDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLN 480
Query: 502 AQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
Q++YS ++S++ A+A + ++ Q+G + + D E + + LT+ ARD G P+
Sbjct: 481 GQVSYSIMASDLEPLALASY---VSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPA 537
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDADV 610
LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 538 LSANVSLRVLVGDRNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADS 594
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
G N + Y + + E G F + +G +RT +AL A L DGG PP S+T
Sbjct: 595 GHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSAT 653
Query: 671 VIVHIKIED 679
+H+ D
Sbjct: 654 ATLHLVFAD 662
Score = 214 bits (522), Expect = 4e-54
Identities = 168/581 (28%), Positives = 264/581 (45%), Gaps = 51/581 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F +E + E A GT + A D DIG N+ +Y +
Sbjct: 118 HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKL----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+LNP QD + L +LDRE+ + + +++ A D P
Sbjct: 173 -SLNP-----SFSLIIKEKQD----GSKYPELALEKTLDREQQSYHRLVLTALDGGHP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS T + + + D NDN P F+ Y VS+ E +V + ++ ATD D G NS I
Sbjct: 221 -PLSGTTELRIQVTDANDNPPVFNRDVYRVSLRE--NVPPGTTVLQVSATDQDEGINSEI 277
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
Y+ T FS++S SG+++ K LD+E+ + Y +V+ +DGG T + INI
Sbjct: 278 TYSFY--RTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVE--INI 333
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
+D NDN+P E + EN G I ++ +D D G N E+ + G V
Sbjct: 334 QDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQL-----QGEVPF 388
Query: 308 PITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I ++ + + T G LDRE +Y + +TATD G PP S++ + F
Sbjct: 389 KIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVF 448
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTR--GRFSITSQNGR-G 421
Y V + E+ PPG + + A+D D + ++ Y I + S S + + G
Sbjct: 449 HQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSG 508
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA--PYTA 476
++ + D++Q R + LT+ A D G + +A V + + D N+ AP V A P +
Sbjct: 509 VVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGS 568
Query: 477 SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
++F+ P G V V A D+D G NA ++Y + A F + +TG
Sbjct: 569 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLRTGE 621
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ T + L + L V RDGG P LS T + + D
Sbjct: 622 VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 662
Score = 207 bits (506), Expect = 4e-52
Identities = 167/528 (31%), Positives = 247/528 (46%), Gaps = 36/528 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL- 422
F +E++++E PGT + A DAD N L Y+++ + Q+G
Sbjct: 133 FTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD +Q+ + L ++A D G S T ++I +TDAN+ PVF Y S+
Sbjct: 193 ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P GTTVL VSATD D GIN++ITYS Q F +N ++G ITT K L
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSFYRT---------GQIFSLNSKSGEITTQKKL 303
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E Y + V RDGG L VEI++ D NDN P I+E+A+ GT
Sbjct: 304 DFEETKEYSMVVEGRDGG--GLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTL 361
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR--TNKALDRESVATHDLKA 657
++ + D D G NG ++ +L E +I + + T+ LDRE +++
Sbjct: 362 IALIKIHDQDSGENGEVNCQLQG---EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D G PP SS++ V + I D+ND+ PVF + EN+P G +I ++ A D D G
Sbjct: 419 TATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLG 478
Query: 718 PNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N V YSI D + + + + + DYE R +EL ++A SP
Sbjct: 479 LNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLR-TFELTLQARDQGSPA 537
Query: 774 LWNDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
L +V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 538 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHN 597
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 598 AWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 645
Score = 165 bits (401), Expect = 2e-39
Identities = 138/472 (29%), Positives = 215/472 (45%), Gaps = 46/472 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND+ PVF Y S+RE GTTVL + ATDQD G N+E+ Y+
Sbjct: 229 RIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSF------- 281
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+F ++ +SG + T+ LD E+ Y+++V+ D
Sbjct: 282 --------------YRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG----- 322
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
L + T+ +NI D+NDN P+ + + + E + +IA IK D D G N +
Sbjct: 323 LVAQCTVEINIQDENDNSPEVTFHSLLEMILE--NAVPGTLIALIKIHDQDSGENGEVNC 380
Query: 190 AIIGGNTQMQFSIDSLS-GDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ G ++ F I S S LV TLD EQ Y + I A D G P S++ ++++
Sbjct: 381 QLQG---EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILH 437
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
IRDVNDNAP F+ + + SV EN P G SI +V A D D G+N +++Y++ D +
Sbjct: 438 IRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLAL 497
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ +SG V+ D E ++L + A D G P SA +
Sbjct: 498 ASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPR 557
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 558 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 617
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 618 RTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 667
Score = 135 bits (326), Expect = 2e-30
Identities = 115/400 (28%), Positives = 183/400 (45%), Gaps = 40/400 (10%)
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P G+ VV +D+G + Q + +S+E F ++ ++G + + L
Sbjct: 39 EEMPKGS---VVGNLATDLGFSVQELPTRKLRVSSEK-----PYFTVSAESGELLVSSRL 90
Query: 540 DRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
DRE + G V + V + + D+ND+ P F Q + I E A GT
Sbjct: 91 DREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGT 150
Query: 599 SVSQVGATDADVGLNGRIHYEL--DP------KDREEGSFVIDPASGVIRTNKALDRESV 650
A DAD+GLN Y+L +P K++++GS + A K LDRE
Sbjct: 151 RFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELA-----LEKTLDREQQ 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
+ H L A+DGG PP S T + I++ D ND+PPVF D + EN P GTT+ ++
Sbjct: 206 SYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVS 265
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA 770
A D DEG N+ + YS FSL ++ G E+ T LD+E K+Y +V+
Sbjct: 266 ATDQDEGINSEITYSFY--RTGQIFSLNSKSG----EITTQKKLDFEE-TKEYSMVVEGR 318
Query: 771 -SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD------V 823
L VEI + D NDN+P + ++ ++ P + +D D V
Sbjct: 319 DGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEV 378
Query: 824 TDKLQ----YRILSGNNANLILLNETTGSMTLSPQLNTNV 859
+LQ ++I+S + + L+ + T +P+ N +
Sbjct: 379 NCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418
>BC093877-1|AAH93877.1| 818|Homo sapiens protocadherin gamma
subfamily B, 5 protein.
Length = 818
Score = 250 bits (613), Expect = 4e-65
Identities = 187/609 (30%), Positives = 302/609 (49%), Gaps = 40/609 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SG LL + LDRE++ +A V++ + ++V I D ND+ P+
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEA--VAENPLNFYHVNVEIEDINDHTPK 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F++ ++ + + E ++ A DAD+G NS +Y + + + G
Sbjct: 133 FTQNSFELQISESAQPGTRFILEV--AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
+++L KTLD EQ +RLV+ A DGG P S TT+L I + D NDN P F +++ S
Sbjct: 191 YPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ ENVP G ++++V A D DEG+N+E+TY+ TG + +++ +SG + T +LD
Sbjct: 251 LRENVPPGTTVLQVSATDQDEGINSEITYSFY---RTGQI---FSLNSKSGEITTQKKLD 304
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y ++V DGG T F E+ + E+ PGT +
Sbjct: 305 FEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTF-HSLLEM-ILENAVPGTLI 362
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ D D E+ ++ ++ G + +S+N L+T LD +Q Y +T++A
Sbjct: 363 ALIKIHDQDSGENGEVNCQLQ-GEVPFKIISSSKNSYKLVTDG-TLDREQTPEYNVTITA 420
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G S + V ++I D N+ APVF A Y SV E+ P G ++ V A+D D+G+N
Sbjct: 421 TDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLN 480
Query: 502 AQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
Q++YS ++S++ A+A + ++ Q+G + + D E + + LT+ ARD G P+
Sbjct: 481 GQVSYSIMASDLEPLALASY---VSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPA 537
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDADV 610
LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 538 LSANVSLRVLVGDRNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADS 594
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
G N + Y + + E G F + +G +RT +AL A L DGG PP S+T
Sbjct: 595 GHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSAT 653
Query: 671 VIVHIKIED 679
+H+ D
Sbjct: 654 ATLHLVFAD 662
Score = 214 bits (522), Expect = 4e-54
Identities = 168/581 (28%), Positives = 264/581 (45%), Gaps = 51/581 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F +E + E A GT + A D DIG N+ +Y +
Sbjct: 118 HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKL----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+LNP QD + L +LDRE+ + + +++ A D P
Sbjct: 173 -SLNP-----SFSLIIKEKQD----GSKYPELALEKTLDREQQSYHRLVLTALDGGHP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS T + + + D NDN P F+ Y VS+ E +V + ++ ATD D G NS I
Sbjct: 221 -PLSGTTELRIQVTDANDNPPVFNRDVYRVSLRE--NVPPGTTVLQVSATDQDEGINSEI 277
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
Y+ T FS++S SG+++ K LD+E+ + Y +V+ +DGG T + INI
Sbjct: 278 TYSFY--RTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVE--INI 333
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
+D NDN+P E + EN G I ++ +D D G N E+ + G V
Sbjct: 334 QDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQL-----QGEVPF 388
Query: 308 PITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I ++ + + T G LDRE +Y + +TATD G PP S++ + F
Sbjct: 389 KIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVF 448
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTR--GRFSITSQNGR-G 421
Y V + E+ PPG + + A+D D + ++ Y I + S S + + G
Sbjct: 449 HQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSG 508
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA--PYTA 476
++ + D++Q R + LT+ A D G + +A V + + D N+ AP V A P +
Sbjct: 509 VVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGS 568
Query: 477 SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
++F+ P G V V A D+D G NA ++Y + A F + +TG
Sbjct: 569 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLRTGE 621
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ T + L + L V RDGG P LS T + + D
Sbjct: 622 VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 662
Score = 207 bits (506), Expect = 4e-52
Identities = 167/528 (31%), Positives = 247/528 (46%), Gaps = 36/528 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL- 422
F +E++++E PGT + A DAD N L Y+++ + Q+G
Sbjct: 133 FTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD +Q+ + L ++A D G S T ++I +TDAN+ PVF Y S+
Sbjct: 193 ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P GTTVL VSATD D GIN++ITYS Q F +N ++G ITT K L
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSFYRT---------GQIFSLNSKSGEITTQKKL 303
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E Y + V RDGG L VEI++ D NDN P I+E+A+ GT
Sbjct: 304 DFEETKEYSMVVEGRDGG--GLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTL 361
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR--TNKALDRESVATHDLKA 657
++ + D D G NG ++ +L E +I + + T+ LDRE +++
Sbjct: 362 IALIKIHDQDSGENGEVNCQLQG---EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D G PP SS++ V + I D+ND+ PVF + EN+P G +I ++ A D D G
Sbjct: 419 TATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLG 478
Query: 718 PNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N V YSI D + + + + + DYE R +EL ++A SP
Sbjct: 479 LNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLR-TFELTLQARDQGSPA 537
Query: 774 LWNDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
L +V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 538 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHN 597
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 598 AWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 645
Score = 165 bits (401), Expect = 2e-39
Identities = 138/472 (29%), Positives = 215/472 (45%), Gaps = 46/472 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND+ PVF Y S+RE GTTVL + ATDQD G N+E+ Y+
Sbjct: 229 RIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSF------- 281
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+F ++ +SG + T+ LD E+ Y+++V+ D
Sbjct: 282 --------------YRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG----- 322
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
L + T+ +NI D+NDN P+ + + + E + +IA IK D D G N +
Sbjct: 323 LVAQCTVEINIQDENDNSPEVTFHSLLEMILE--NAVPGTLIALIKIHDQDSGENGEVNC 380
Query: 190 AIIGGNTQMQFSIDSLS-GDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ G ++ F I S S LV TLD EQ Y + I A D G P S++ ++++
Sbjct: 381 QLQG---EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILH 437
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
IRDVNDNAP F+ + + SV EN P G SI +V A D D G+N +++Y++ D +
Sbjct: 438 IRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLAL 497
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ +SG V+ D E ++L + A D G P SA +
Sbjct: 498 ASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPR 557
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 558 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 617
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 618 RTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 667
Score = 135 bits (326), Expect = 2e-30
Identities = 115/400 (28%), Positives = 183/400 (45%), Gaps = 40/400 (10%)
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P G+ VV +D+G + Q + +S+E F ++ ++G + + L
Sbjct: 39 EEMPKGS---VVGNLATDLGFSVQELPTRKLRVSSEK-----PYFTVSAESGELLVSSRL 90
Query: 540 DRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
DRE + G V + V + + D+ND+ P F Q + I E A GT
Sbjct: 91 DREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGT 150
Query: 599 SVSQVGATDADVGLNGRIHYEL--DP------KDREEGSFVIDPASGVIRTNKALDRESV 650
A DAD+GLN Y+L +P K++++GS + A K LDRE
Sbjct: 151 RFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELA-----LEKTLDREQQ 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
+ H L A+DGG PP S T + I++ D ND+PPVF D + EN P GTT+ ++
Sbjct: 206 SYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVS 265
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA 770
A D DEG N+ + YS FSL ++ G E+ T LD+E K+Y +V+
Sbjct: 266 ATDQDEGINSEITYSFY--RTGQIFSLNSKSG----EITTQKKLDFEE-TKEYSMVVEGR 318
Query: 771 -SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD------V 823
L VEI + D NDN+P + ++ ++ P + +D D V
Sbjct: 319 DGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEV 378
Query: 824 TDKLQ----YRILSGNNANLILLNETTGSMTLSPQLNTNV 859
+LQ ++I+S + + L+ + T +P+ N +
Sbjct: 379 NCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418
>AF152521-1|AAD43781.1| 818|Homo sapiens protocadherin gamma B5
short form protein protein.
Length = 818
Score = 250 bits (613), Expect = 4e-65
Identities = 187/609 (30%), Positives = 302/609 (49%), Gaps = 40/609 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SG LL + LDRE++ +A V++ + ++V I D ND+ P+
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEA--VAENPLNFYHVNVEIEDINDHTPK 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F++ ++ + + E ++ A DAD+G NS +Y + + + G
Sbjct: 133 FTQNSFELQISESAQPGTRFILEV--AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
+++L KTLD EQ +RLV+ A DGG P S TT+L I + D NDN P F +++ S
Sbjct: 191 YPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ ENVP G ++++V A D DEG+N+E+TY+ TG + +++ +SG + T +LD
Sbjct: 251 LRENVPPGTTVLQVSATDQDEGINSEITYSFY---RTGQI---FSLNSKSGEITTQKKLD 304
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y ++V DGG T F E+ + E+ PGT +
Sbjct: 305 FEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTF-HSLLEM-ILENAVPGTLI 362
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ D D E+ ++ ++ G + +S+N L+T LD +Q Y +T++A
Sbjct: 363 ALIKIHDQDSGENGEVNCQLQ-GEVPFKIISSSKNSYKLVTDG-TLDREQTPEYNVTITA 420
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G S + V ++I D N+ APVF A Y SV E+ P G ++ V A+D D+G+N
Sbjct: 421 TDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLN 480
Query: 502 AQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
Q++YS ++S++ A+A + ++ Q+G + + D E + + LT+ ARD G P+
Sbjct: 481 GQVSYSIMASDLEPLALASY---VSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPA 537
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDADV 610
LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 538 LSANVSLRVLVGDRNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADS 594
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
G N + Y + + E G F + +G +RT +AL A L DGG PP S+T
Sbjct: 595 GHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSAT 653
Query: 671 VIVHIKIED 679
+H+ D
Sbjct: 654 ATLHLVFAD 662
Score = 214 bits (522), Expect = 4e-54
Identities = 168/581 (28%), Positives = 264/581 (45%), Gaps = 51/581 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F +E + E A GT + A D DIG N+ +Y +
Sbjct: 118 HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKL----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+LNP QD + L +LDRE+ + + +++ A D P
Sbjct: 173 -SLNP-----SFSLIIKEKQD----GSKYPELALEKTLDREQQSYHRLVLTALDGGHP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS T + + + D NDN P F+ Y VS+ E +V + ++ ATD D G NS I
Sbjct: 221 -PLSGTTELRIQVTDANDNPPVFNRDVYRVSLRE--NVPPGTTVLQVSATDQDEGINSEI 277
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
Y+ T FS++S SG+++ K LD+E+ + Y +V+ +DGG T + INI
Sbjct: 278 TYSFY--RTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVE--INI 333
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
+D NDN+P E + EN G I ++ +D D G N E+ + G V
Sbjct: 334 QDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQL-----QGEVPF 388
Query: 308 PITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I ++ + + T G LDRE +Y + +TATD G PP S++ + F
Sbjct: 389 KIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVF 448
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTR--GRFSITSQNGR-G 421
Y V + E+ PPG + + A+D D + ++ Y I + S S + + G
Sbjct: 449 HQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSG 508
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA--PYTA 476
++ + D++Q R + LT+ A D G + +A V + + D N+ AP V A P +
Sbjct: 509 VVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGS 568
Query: 477 SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
++F+ P G V V A D+D G NA ++Y + A F + +TG
Sbjct: 569 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLRTGE 621
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ T + L + L V RDGG P LS T + + D
Sbjct: 622 VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 662
Score = 207 bits (506), Expect = 4e-52
Identities = 167/528 (31%), Positives = 247/528 (46%), Gaps = 36/528 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL- 422
F +E++++E PGT + A DAD N L Y+++ + Q+G
Sbjct: 133 FTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD +Q+ + L ++A D G S T ++I +TDAN+ PVF Y S+
Sbjct: 193 ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P GTTVL VSATD D GIN++ITYS Q F +N ++G ITT K L
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSFYRT---------GQIFSLNSKSGEITTQKKL 303
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E Y + V RDGG L VEI++ D NDN P I+E+A+ GT
Sbjct: 304 DFEETKEYSMVVEGRDGG--GLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTL 361
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR--TNKALDRESVATHDLKA 657
++ + D D G NG ++ +L E +I + + T+ LDRE +++
Sbjct: 362 IALIKIHDQDSGENGEVNCQLQG---EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D G PP SS++ V + I D+ND+ PVF + EN+P G +I ++ A D D G
Sbjct: 419 TATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLG 478
Query: 718 PNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N V YSI D + + + + + DYE R +EL ++A SP
Sbjct: 479 LNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLR-TFELTLQARDQGSPA 537
Query: 774 LWNDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
L +V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 538 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHN 597
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 598 AWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 645
Score = 165 bits (401), Expect = 2e-39
Identities = 138/472 (29%), Positives = 215/472 (45%), Gaps = 46/472 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND+ PVF Y S+RE GTTVL + ATDQD G N+E+ Y+
Sbjct: 229 RIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSF------- 281
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+F ++ +SG + T+ LD E+ Y+++V+ D
Sbjct: 282 --------------YRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG----- 322
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
L + T+ +NI D+NDN P+ + + + E + +IA IK D D G N +
Sbjct: 323 LVAQCTVEINIQDENDNSPEVTFHSLLEMILE--NAVPGTLIALIKIHDQDSGENGEVNC 380
Query: 190 AIIGGNTQMQFSIDSLS-GDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ G ++ F I S S LV TLD EQ Y + I A D G P S++ ++++
Sbjct: 381 QLQG---EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILH 437
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
IRDVNDNAP F+ + + SV EN P G SI +V A D D G+N +++Y++ D +
Sbjct: 438 IRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLAL 497
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ +SG V+ D E ++L + A D G P SA +
Sbjct: 498 ASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPR 557
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 558 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 617
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 618 RTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 667
Score = 135 bits (326), Expect = 2e-30
Identities = 115/400 (28%), Positives = 183/400 (45%), Gaps = 40/400 (10%)
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P G+ VV +D+G + Q + +S+E F ++ ++G + + L
Sbjct: 39 EEMPKGS---VVGNLATDLGFSVQELPTRKLRVSSEK-----PYFTVSAESGELLVSSRL 90
Query: 540 DRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
DRE + G V + V + + D+ND+ P F Q + I E A GT
Sbjct: 91 DREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGT 150
Query: 599 SVSQVGATDADVGLNGRIHYEL--DP------KDREEGSFVIDPASGVIRTNKALDRESV 650
A DAD+GLN Y+L +P K++++GS + A K LDRE
Sbjct: 151 RFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELA-----LEKTLDREQQ 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
+ H L A+DGG PP S T + I++ D ND+PPVF D + EN P GTT+ ++
Sbjct: 206 SYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVS 265
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA 770
A D DEG N+ + YS FSL ++ G E+ T LD+E K+Y +V+
Sbjct: 266 ATDQDEGINSEITYSFY--RTGQIFSLNSKSG----EITTQKKLDFEE-TKEYSMVVEGR 318
Query: 771 -SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD------V 823
L VEI + D NDN+P + ++ ++ P + +D D V
Sbjct: 319 DGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEV 378
Query: 824 TDKLQ----YRILSGNNANLILLNETTGSMTLSPQLNTNV 859
+LQ ++I+S + + L+ + T +P+ N +
Sbjct: 379 NCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418
>AF152334-1|AAD43728.1| 923|Homo sapiens protocadherin gamma B5
protein.
Length = 923
Score = 250 bits (613), Expect = 4e-65
Identities = 187/609 (30%), Positives = 302/609 (49%), Gaps = 40/609 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F + SG LL + LDRE++ +A V++ + ++V I D ND+ P+
Sbjct: 75 FTVSAESGELLVSSRLDREEICGKKPACALEFEA--VAENPLNFYHVNVEIEDINDHTPK 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG-- 207
F++ ++ + + E ++ A DAD+G NS +Y + + + G
Sbjct: 133 FTQNSFELQISESAQPGTRFILEV--AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
+++L KTLD EQ +RLV+ A DGG P S TT+L I + D NDN P F +++ S
Sbjct: 191 YPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVS 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+ ENVP G ++++V A D DEG+N+E+TY+ TG + +++ +SG + T +LD
Sbjct: 251 LRENVPPGTTVLQVSATDQDEGINSEITYSFY---RTGQI---FSLNSKSGEITTQKKLD 304
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E +Y ++V DGG T F E+ + E+ PGT +
Sbjct: 305 FEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTF-HSLLEM-ILENAVPGTLI 362
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ D D E+ ++ ++ G + +S+N L+T LD +Q Y +T++A
Sbjct: 363 ALIKIHDQDSGENGEVNCQLQ-GEVPFKIISSSKNSYKLVTDG-TLDREQTPEYNVTITA 420
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G S + V ++I D N+ APVF A Y SV E+ P G ++ V A+D D+G+N
Sbjct: 421 TDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLN 480
Query: 502 AQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
Q++YS ++S++ A+A + ++ Q+G + + D E + + LT+ ARD G P+
Sbjct: 481 GQVSYSIMASDLEPLALASY---VSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPA 537
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATDADV 610
LS + + V D NDN P + LY A + A G V++V A DAD
Sbjct: 538 LSANVSLRVLVGDRNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADS 594
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
G N + Y + + E G F + +G +RT +AL A L DGG PP S+T
Sbjct: 595 GHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSAT 653
Query: 671 VIVHIKIED 679
+H+ D
Sbjct: 654 ATLHLVFAD 662
Score = 214 bits (522), Expect = 4e-54
Identities = 168/581 (28%), Positives = 264/581 (45%), Gaps = 51/581 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D NDH+P F +E + E A GT + A D DIG N+ +Y +
Sbjct: 118 HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKL----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+LNP QD + L +LDRE+ + + +++ A D P
Sbjct: 173 -SLNP-----SFSLIIKEKQD----GSKYPELALEKTLDREQQSYHRLVLTALDGGHP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS T + + + D NDN P F+ Y VS+ E +V + ++ ATD D G NS I
Sbjct: 221 -PLSGTTELRIQVTDANDNPPVFNRDVYRVSLRE--NVPPGTTVLQVSATDQDEGINSEI 277
Query: 188 RYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
Y+ T FS++S SG+++ K LD+E+ + Y +V+ +DGG T + INI
Sbjct: 278 TYSFY--RTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVE--INI 333
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
+D NDN+P E + EN G I ++ +D D G N E+ + G V
Sbjct: 334 QDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQL-----QGEVPF 388
Query: 308 PITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I ++ + + T G LDRE +Y + +TATD G PP S++ + F
Sbjct: 389 KIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVF 448
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTR--GRFSITSQNGR-G 421
Y V + E+ PPG + + A+D D + ++ Y I + S S + + G
Sbjct: 449 HQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSG 508
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA--PYTA 476
++ + D++Q R + LT+ A D G + +A V + + D N+ AP V A P +
Sbjct: 509 VVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGS 568
Query: 477 SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
++F+ P G V V A D+D G NA ++Y + A F + +TG
Sbjct: 569 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLRTGE 621
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ T + L + L V RDGG P LS T + + D
Sbjct: 622 VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFAD 662
Score = 207 bits (506), Expect = 4e-52
Identities = 167/528 (31%), Positives = 247/528 (46%), Gaps = 36/528 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL- 422
F +E++++E PGT + A DAD N L Y+++ + Q+G
Sbjct: 133 FTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD +Q+ + L ++A D G S T ++I +TDAN+ PVF Y S+
Sbjct: 193 ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P GTTVL VSATD D GIN++ITYS Q F +N ++G ITT K L
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSFYRT---------GQIFSLNSKSGEITTQKKL 303
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E Y + V RDGG L VEI++ D NDN P I+E+A+ GT
Sbjct: 304 DFEETKEYSMVVEGRDGG--GLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTL 361
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR--TNKALDRESVATHDLKA 657
++ + D D G NG ++ +L E +I + + T+ LDRE +++
Sbjct: 362 IALIKIHDQDSGENGEVNCQLQG---EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D G PP SS++ V + I D+ND+ PVF + EN+P G +I ++ A D D G
Sbjct: 419 TATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLG 478
Query: 718 PNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
N V YSI D + + + + + DYE R +EL ++A SP
Sbjct: 479 LNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLR-TFELTLQARDQGSPA 537
Query: 774 LWNDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
L +V + +LV D NDNAP + D +F+ G +V A DAD
Sbjct: 538 LSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHN 597
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 598 AWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 645
Score = 165 bits (401), Expect = 2e-39
Identities = 138/472 (29%), Positives = 215/472 (45%), Gaps = 46/472 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND+ PVF Y S+RE GTTVL + ATDQD G N+E+ Y+
Sbjct: 229 RIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSF------- 281
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+F ++ +SG + T+ LD E+ Y+++V+ D
Sbjct: 282 --------------YRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG----- 322
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
L + T+ +NI D+NDN P+ + + + E + +IA IK D D G N +
Sbjct: 323 LVAQCTVEINIQDENDNSPEVTFHSLLEMILE--NAVPGTLIALIKIHDQDSGENGEVNC 380
Query: 190 AIIGGNTQMQFSIDSLS-GDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ G ++ F I S S LV TLD EQ Y + I A D G P S++ ++++
Sbjct: 381 QLQG---EVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILH 437
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
IRDVNDNAP F+ + + SV EN P G SI +V A D D G+N +++Y++ D +
Sbjct: 438 IRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLAL 497
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ +SG V+ D E ++L + A D G P SA +
Sbjct: 498 ASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPR 557
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 558 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 617
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 618 RTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADSLQEV 667
Score = 135 bits (326), Expect = 2e-30
Identities = 115/400 (28%), Positives = 183/400 (45%), Gaps = 40/400 (10%)
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ P G+ VV +D+G + Q + +S+E F ++ ++G + + L
Sbjct: 39 EEMPKGS---VVGNLATDLGFSVQELPTRKLRVSSEK-----PYFTVSAESGELLVSSRL 90
Query: 540 DRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
DRE + G V + V + + D+ND+ P F Q + I E A GT
Sbjct: 91 DREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGT 150
Query: 599 SVSQVGATDADVGLNGRIHYEL--DP------KDREEGSFVIDPASGVIRTNKALDRESV 650
A DAD+GLN Y+L +P K++++GS + A K LDRE
Sbjct: 151 RFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELA-----LEKTLDREQQ 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
+ H L A+DGG PP S T + I++ D ND+PPVF D + EN P GTT+ ++
Sbjct: 206 SYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVS 265
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA 770
A D DEG N+ + YS FSL ++ G E+ T LD+E K+Y +V+
Sbjct: 266 ATDQDEGINSEITYSFY--RTGQIFSLNSKSG----EITTQKKLDFEE-TKEYSMVVEGR 318
Query: 771 -SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD------V 823
L VEI + D NDN+P + ++ ++ P + +D D V
Sbjct: 319 DGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEV 378
Query: 824 TDKLQ----YRILSGNNANLILLNETTGSMTLSPQLNTNV 859
+LQ ++I+S + + L+ + T +P+ N +
Sbjct: 379 NCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTI 418
>BC101805-1|AAI01806.1| 811|Homo sapiens protocadherin gamma
subfamily B, 2 protein.
Length = 811
Score = 246 bits (602), Expect = 9e-64
Identities = 181/612 (29%), Positives = 295/612 (48%), Gaps = 36/612 (5%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
++ F ++ SG LL +DRE++ L V++ + I V + D NDN
Sbjct: 72 KEYFTVNPESGDLLVSDRIDREQICGKQPLCVL--DFDTVAENPLNIFYIAVIVQDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN----TQMQFSI 202
P F + + + E S A D+DVG NS RY + + Q
Sbjct: 130 TPLFKQTKINLKIGE--STKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPD 187
Query: 203 DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
++ L +LD E+ ++LV+ A DGG P +S TTQ+ I + D NDN P F ++
Sbjct: 188 GRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ++ E+VP G+ +++V A D DEG+NAE+TY+ + D V ++ ++G + T
Sbjct: 248 RVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVD--EQVKHFFNLNEKTGEITTKD 305
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
LD E + Y L + A D GD +A + + L ED PPG
Sbjct: 306 DLDFEIASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSPPG 363
Query: 383 TPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + + D D E+ ++ ++ GN + +S+N L+T LD ++ Y LT
Sbjct: 364 TVIALIKTRDRDSGENGEVYCQVL-GNAKFILKSSSKNYYKLVTDG-ALDREEIPEYNLT 421
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
++ATD G S + +V ++I+D N+ APVF+ Y V E+ P G ++ +SA+D D+
Sbjct: 422 ITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDL 481
Query: 499 GINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G + Q++YS+ +S++ + + ++ Q+G + + D E + + LT+ ARD G
Sbjct: 482 GPSGQVSYSIVASDLKPREILSY---VSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQG 538
Query: 558 VPSLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATD 607
P+LS + + V D+NDN P + LY A + A G V++V A D
Sbjct: 539 SPALSANVSLRVLVGDLNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVD 595
Query: 608 ADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
AD G N + Y + + E G F + +G +RT +AL A L DGG PP
Sbjct: 596 ADSGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPL 654
Query: 668 SSTVIVHIKIED 679
S+T +H+ D
Sbjct: 655 SATATLHLIFAD 666
Score = 215 bits (524), Expect = 3e-54
Identities = 178/586 (30%), Positives = 272/586 (46%), Gaps = 35/586 (5%)
Query: 310 TIDPRSGWVYTSGQLDRETQA-KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
T++P SG + S ++DRE K L V D F
Sbjct: 76 TVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQ 135
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL--IT 424
+ +++ E PGT A D+D N L Y + + +GR +
Sbjct: 136 TKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGRKYPELI 195
Query: 425 VAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+ LD ++ + L ++A D G +S T ++I +TDAN+ PVF Y ++ ED
Sbjct: 196 LKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDV 255
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
P G VL V+ATD D GINA+ITYS + +E V H F +N +TG ITT LD E
Sbjct: 256 PPGFFVLQVTATDRDEGINAEITYSFHNV--DEQVKHF---FNLNEKTGEITTKDDLDFE 310
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
S Y L++ A+D G L+ +++ ++D ND P + + ED+ GT ++
Sbjct: 311 IASSYTLSIEAKDPG--DLAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIAL 368
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKAVA 659
+ D D G NG ++ ++ F++ +S + T+ ALDRE + ++L A
Sbjct: 369 IKTRDRDSGENGEVYCQV----LGNAKFILKSSSKNYYKLVTDGALDREEIPEYNLTITA 424
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG PP SS++IV + I D+ND+ PVF+ +++EN+P G +I +I A DPD GP+
Sbjct: 425 TDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPS 484
Query: 720 AVVHYSIKGGDDSNSFSLETRQGSDKAELV-TMVDLDYESPRKKYELVIRA---ASPPLW 775
V YSI D L S ++ +V D+E R +EL ++A SP L
Sbjct: 485 GQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLR-AFELTLQARDQGSPALS 543
Query: 776 NDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK-- 826
+V + +LV D+NDNAP + D +F+ G +V A DAD
Sbjct: 544 ANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAW 603
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 604 LSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 649
Score = 192 bits (468), Expect = 2e-47
Identities = 165/579 (28%), Positives = 262/579 (45%), Gaps = 53/579 (9%)
Query: 13 VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNP 72
V D ND++P+F+ + + E GTT A D D+G N+ Y LN
Sbjct: 123 VQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRY--------HLND 174
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSDRLS 131
+ + + DGR L+ + SLDRE+ + + +++ A D P S
Sbjct: 175 NE--------YFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQ---S 223
Query: 132 STATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI 191
T I + + D NDN P FS+ Y V++ ED V + ++ ATD D G N+ I Y+
Sbjct: 224 GTTQIRIKVTDANDNPPVFSQDVYRVTLRED--VPPGFFVLQVTATDRDEGINAEITYSF 281
Query: 192 IGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
+ Q++ F+++ +G+++ LD+E SY L I A+D G + + Q + I D
Sbjct: 282 HNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQ--VEILD 339
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
ND AP + + E+ P G I ++ D D G N E+ Y GN +
Sbjct: 340 DNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEV-YCQV----LGNAKFIL 394
Query: 310 TIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
++ + + T G LDRE +Y L +TATDGG PP S++ F
Sbjct: 395 KSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQ 454
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR--FSITSQNGR-GLI 423
Y V +AE+ PPG + ++A+D D ++ Y I + + R S S + + G++
Sbjct: 455 TSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVV 514
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA--PYTASV 478
+ D +Q R + LT+ A D G + +A V + + D N+ AP V A P +++
Sbjct: 515 FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSAL 574
Query: 479 FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
F+ P G V V A D+D G NA ++Y + A F + +TG +
Sbjct: 575 FDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLRTGEVR 627
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
T + L + L V RDGG P LS T + + D
Sbjct: 628 TARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFAD 666
Score = 161 bits (391), Expect = 3e-38
Identities = 136/472 (28%), Positives = 214/472 (45%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND+ PVF Y ++RE G VL + ATD+D G NAE+ Y+ V
Sbjct: 229 RIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQ- 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+ F ++ ++G + T+ LD E + YT+ ++A D
Sbjct: 288 ----------------VKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGD----- 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
L++ +I V I+DDND P+ + + + ED VIA IK D D G N + Y
Sbjct: 327 LAAHCSIQVEILDDNDCAPEVIVTSVSTPLPED--SPPGTVIALIKTRDRDSGENGEV-Y 383
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ GN +F + S S + + T LD E++ Y L I A DGG P S++ + ++
Sbjct: 384 CQVLGNA--KFILKSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLH 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I DVNDNAP F + + V+EN P G SI ++ A D D G + +++Y++ D
Sbjct: 442 ISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREI 501
Query: 307 LP-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
L +++ +SG V+ D E ++L + A D G P SA +
Sbjct: 502 LSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPR 561
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 562 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 622 RTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEV 671
Score = 133 bits (322), Expect = 8e-30
Identities = 93/283 (32%), Positives = 134/283 (47%), Gaps = 12/283 (4%)
Query: 517 VAHHDQQFVINPQTGAITTNKLLDRETMSG-YLLTVTARDGGVPSLSDTTDVEISVVDVN 575
V+ + F +NP++G + + +DRE + G L V D + + + + V D+N
Sbjct: 68 VSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDIN 127
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFVI 632
DN P+FKQ I E GT+ A D+DVG N Y L+ D E
Sbjct: 128 DNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPD 187
Query: 633 DPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL 692
+ +LDRE + H L A+DGG PPQS T + IK+ D ND+PPVF D
Sbjct: 188 GRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVY 247
Query: 693 TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVT 750
+ E+ P G + ++ A D DEG NA + YS D+ + F+L + G E+ T
Sbjct: 248 RVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTG----EITT 303
Query: 751 MVDLDYESPRKKYELVIRAASP-PLWNDVRVEILVTDVNDNAP 792
DLD+E Y L I A P L +++ + D ND AP
Sbjct: 304 KDDLDFEI-ASSYTLSIEAKDPGDLAAHCSIQVEILDDNDCAP 345
>AF152518-1|AAD43778.1| 811|Homo sapiens protocadherin gamma B2
short form protein protein.
Length = 811
Score = 246 bits (602), Expect = 9e-64
Identities = 181/612 (29%), Positives = 295/612 (48%), Gaps = 36/612 (5%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
++ F ++ SG LL +DRE++ L V++ + I V + D NDN
Sbjct: 72 KEYFTVNPESGDLLVSDRIDREQICGKQPLCVL--DFDTVAENPLNIFYIAVIVQDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN----TQMQFSI 202
P F + + + E S A D+DVG NS RY + + Q
Sbjct: 130 TPLFKQTKINLKIGE--STKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPD 187
Query: 203 DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
++ L +LD E+ ++LV+ A DGG P +S TTQ+ I + D NDN P F ++
Sbjct: 188 GRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ++ E+VP G+ +++V A D DEG+NAE+TY+ + D V ++ ++G + T
Sbjct: 248 RVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVD--EQVKHFFNLNEKTGEITTKD 305
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
LD E + Y L + A D GD +A + + L ED PPG
Sbjct: 306 DLDFEIASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSPPG 363
Query: 383 TPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + + D D E+ ++ ++ GN + +S+N L+T LD ++ Y LT
Sbjct: 364 TVIALIKTRDRDSGENGEVYCQVL-GNAKFILKSSSKNYYKLVTDG-ALDREEIPEYNLT 421
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
++ATD G S + +V ++I+D N+ APVF+ Y V E+ P G ++ +SA+D D+
Sbjct: 422 ITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDL 481
Query: 499 GINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G + Q++YS+ +S++ + + ++ Q+G + + D E + + LT+ ARD G
Sbjct: 482 GPSGQVSYSIVASDLKPREILSY---VSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQG 538
Query: 558 VPSLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATD 607
P+LS + + V D+NDN P + LY A + A G V++V A D
Sbjct: 539 SPALSANVSLRVLVGDLNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVD 595
Query: 608 ADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
AD G N + Y + + E G F + +G +RT +AL A L DGG PP
Sbjct: 596 ADSGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPL 654
Query: 668 SSTVIVHIKIED 679
S+T +H+ D
Sbjct: 655 SATATLHLIFAD 666
Score = 215 bits (524), Expect = 3e-54
Identities = 178/586 (30%), Positives = 272/586 (46%), Gaps = 35/586 (5%)
Query: 310 TIDPRSGWVYTSGQLDRETQA-KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
T++P SG + S ++DRE K L V D F
Sbjct: 76 TVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQ 135
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL--IT 424
+ +++ E PGT A D+D N L Y + + +GR +
Sbjct: 136 TKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGRKYPELI 195
Query: 425 VAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+ LD ++ + L ++A D G +S T ++I +TDAN+ PVF Y ++ ED
Sbjct: 196 LKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDV 255
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
P G VL V+ATD D GINA+ITYS + +E V H F +N +TG ITT LD E
Sbjct: 256 PPGFFVLQVTATDRDEGINAEITYSFHNV--DEQVKHF---FNLNEKTGEITTKDDLDFE 310
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
S Y L++ A+D G L+ +++ ++D ND P + + ED+ GT ++
Sbjct: 311 IASSYTLSIEAKDPG--DLAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIAL 368
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKAVA 659
+ D D G NG ++ ++ F++ +S + T+ ALDRE + ++L A
Sbjct: 369 IKTRDRDSGENGEVYCQV----LGNAKFILKSSSKNYYKLVTDGALDREEIPEYNLTITA 424
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG PP SS++IV + I D+ND+ PVF+ +++EN+P G +I +I A DPD GP+
Sbjct: 425 TDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPS 484
Query: 720 AVVHYSIKGGDDSNSFSLETRQGSDKAELV-TMVDLDYESPRKKYELVIRA---ASPPLW 775
V YSI D L S ++ +V D+E R +EL ++A SP L
Sbjct: 485 GQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLR-AFELTLQARDQGSPALS 543
Query: 776 NDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK-- 826
+V + +LV D+NDNAP + D +F+ G +V A DAD
Sbjct: 544 ANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAW 603
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 604 LSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 649
Score = 192 bits (468), Expect = 2e-47
Identities = 165/579 (28%), Positives = 262/579 (45%), Gaps = 53/579 (9%)
Query: 13 VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNP 72
V D ND++P+F+ + + E GTT A D D+G N+ Y LN
Sbjct: 123 VQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRY--------HLND 174
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSDRLS 131
+ + + DGR L+ + SLDRE+ + + +++ A D P S
Sbjct: 175 NE--------YFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQ---S 223
Query: 132 STATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI 191
T I + + D NDN P FS+ Y V++ ED V + ++ ATD D G N+ I Y+
Sbjct: 224 GTTQIRIKVTDANDNPPVFSQDVYRVTLRED--VPPGFFVLQVTATDRDEGINAEITYSF 281
Query: 192 IGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
+ Q++ F+++ +G+++ LD+E SY L I A+D G + + Q + I D
Sbjct: 282 HNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQ--VEILD 339
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
ND AP + + E+ P G I ++ D D G N E+ Y GN +
Sbjct: 340 DNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEV-YCQV----LGNAKFIL 394
Query: 310 TIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
++ + + T G LDRE +Y L +TATDGG PP S++ F
Sbjct: 395 KSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQ 454
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR--FSITSQNGR-GLI 423
Y V +AE+ PPG + ++A+D D ++ Y I + + R S S + + G++
Sbjct: 455 TSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVV 514
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA--PYTASV 478
+ D +Q R + LT+ A D G + +A V + + D N+ AP V A P +++
Sbjct: 515 FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSAL 574
Query: 479 FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
F+ P G V V A D+D G NA ++Y + A F + +TG +
Sbjct: 575 FDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLRTGEVR 627
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
T + L + L V RDGG P LS T + + D
Sbjct: 628 TARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFAD 666
Score = 161 bits (391), Expect = 3e-38
Identities = 136/472 (28%), Positives = 214/472 (45%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND+ PVF Y ++RE G VL + ATD+D G NAE+ Y+ V
Sbjct: 229 RIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQ- 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+ F ++ ++G + T+ LD E + YT+ ++A D
Sbjct: 288 ----------------VKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGD----- 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
L++ +I V I+DDND P+ + + + ED VIA IK D D G N + Y
Sbjct: 327 LAAHCSIQVEILDDNDCAPEVIVTSVSTPLPED--SPPGTVIALIKTRDRDSGENGEV-Y 383
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ GN +F + S S + + T LD E++ Y L I A DGG P S++ + ++
Sbjct: 384 CQVLGNA--KFILKSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLH 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I DVNDNAP F + + V+EN P G SI ++ A D D G + +++Y++ D
Sbjct: 442 ISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREI 501
Query: 307 LP-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
L +++ +SG V+ D E ++L + A D G P SA +
Sbjct: 502 LSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPR 561
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 562 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 622 RTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEV 671
Score = 133 bits (322), Expect = 8e-30
Identities = 93/283 (32%), Positives = 134/283 (47%), Gaps = 12/283 (4%)
Query: 517 VAHHDQQFVINPQTGAITTNKLLDRETMSG-YLLTVTARDGGVPSLSDTTDVEISVVDVN 575
V+ + F +NP++G + + +DRE + G L V D + + + + V D+N
Sbjct: 68 VSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDIN 127
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFVI 632
DN P+FKQ I E GT+ A D+DVG N Y L+ D E
Sbjct: 128 DNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPD 187
Query: 633 DPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL 692
+ +LDRE + H L A+DGG PPQS T + IK+ D ND+PPVF D
Sbjct: 188 GRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVY 247
Query: 693 TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVT 750
+ E+ P G + ++ A D DEG NA + YS D+ + F+L + G E+ T
Sbjct: 248 RVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTG----EITT 303
Query: 751 MVDLDYESPRKKYELVIRAASP-PLWNDVRVEILVTDVNDNAP 792
DLD+E Y L I A P L +++ + D ND AP
Sbjct: 304 KDDLDFEI-ASSYTLSIEAKDPGDLAAHCSIQVEILDDNDCAP 345
>AF152331-1|AAD43725.1| 931|Homo sapiens protocadherin gamma B2
protein.
Length = 931
Score = 246 bits (602), Expect = 9e-64
Identities = 181/612 (29%), Positives = 295/612 (48%), Gaps = 36/612 (5%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
++ F ++ SG LL +DRE++ L V++ + I V + D NDN
Sbjct: 72 KEYFTVNPESGDLLVSDRIDREQICGKQPLCVL--DFDTVAENPLNIFYIAVIVQDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN----TQMQFSI 202
P F + + + E S A D+DVG NS RY + + Q
Sbjct: 130 TPLFKQTKINLKIGE--STKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPD 187
Query: 203 DSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
++ L +LD E+ ++LV+ A DGG P +S TTQ+ I + D NDN P F ++
Sbjct: 188 GRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ++ E+VP G+ +++V A D DEG+NAE+TY+ + D V ++ ++G + T
Sbjct: 248 RVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVD--EQVKHFFNLNEKTGEITTKD 305
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
LD E + Y L + A D GD +A + + L ED PPG
Sbjct: 306 DLDFEIASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSPPG 363
Query: 383 TPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + + D D E+ ++ ++ GN + +S+N L+T LD ++ Y LT
Sbjct: 364 TVIALIKTRDRDSGENGEVYCQVL-GNAKFILKSSSKNYYKLVTDG-ALDREEIPEYNLT 421
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
++ATD G S + +V ++I+D N+ APVF+ Y V E+ P G ++ +SA+D D+
Sbjct: 422 ITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDL 481
Query: 499 GINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G + Q++YS+ +S++ + + ++ Q+G + + D E + + LT+ ARD G
Sbjct: 482 GPSGQVSYSIVASDLKPREILSY---VSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQG 538
Query: 558 VPSLSDTTDVEISVVDVNDNEPVFKQQLYTA----------NIMEDALVGTSVSQVGATD 607
P+LS + + V D+NDN P + LY A + A G V++V A D
Sbjct: 539 SPALSANVSLRVLVGDLNDNAP---RVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVD 595
Query: 608 ADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
AD G N + Y + + E G F + +G +RT +AL A L DGG PP
Sbjct: 596 ADSGHNAWLSYHV-LQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPL 654
Query: 668 SSTVIVHIKIED 679
S+T +H+ D
Sbjct: 655 SATATLHLIFAD 666
Score = 215 bits (524), Expect = 3e-54
Identities = 178/586 (30%), Positives = 272/586 (46%), Gaps = 35/586 (5%)
Query: 310 TIDPRSGWVYTSGQLDRETQA-KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
T++P SG + S ++DRE K L V D F
Sbjct: 76 TVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQ 135
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL--IT 424
+ +++ E PGT A D+D N L Y + + +GR +
Sbjct: 136 TKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGRKYPELI 195
Query: 425 VAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+ LD ++ + L ++A D G +S T ++I +TDAN+ PVF Y ++ ED
Sbjct: 196 LKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDV 255
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
P G VL V+ATD D GINA+ITYS + +E V H F +N +TG ITT LD E
Sbjct: 256 PPGFFVLQVTATDRDEGINAEITYSFHNV--DEQVKHF---FNLNEKTGEITTKDDLDFE 310
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
S Y L++ A+D G L+ +++ ++D ND P + + ED+ GT ++
Sbjct: 311 IASSYTLSIEAKDPG--DLAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIAL 368
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKAVA 659
+ D D G NG ++ ++ F++ +S + T+ ALDRE + ++L A
Sbjct: 369 IKTRDRDSGENGEVYCQV----LGNAKFILKSSSKNYYKLVTDGALDREEIPEYNLTITA 424
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG PP SS++IV + I D+ND+ PVF+ +++EN+P G +I +I A DPD GP+
Sbjct: 425 TDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPS 484
Query: 720 AVVHYSIKGGDDSNSFSLETRQGSDKAELV-TMVDLDYESPRKKYELVIRA---ASPPLW 775
V YSI D L S ++ +V D+E R +EL ++A SP L
Sbjct: 485 GQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLR-AFELTLQARDQGSPALS 543
Query: 776 NDVRVEILVTDVNDNAP------VMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK-- 826
+V + +LV D+NDNAP + D +F+ G +V A DAD
Sbjct: 544 ANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAW 603
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y +L + L L TG + + L + V+V DG
Sbjct: 604 LSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDG 649
Score = 192 bits (468), Expect = 2e-47
Identities = 165/579 (28%), Positives = 262/579 (45%), Gaps = 53/579 (9%)
Query: 13 VLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTLNP 72
V D ND++P+F+ + + E GTT A D D+G N+ Y LN
Sbjct: 123 VQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRY--------HLND 174
Query: 73 EDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSDRLS 131
+ + + DGR L+ + SLDRE+ + + +++ A D P S
Sbjct: 175 NE--------YFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQ---S 223
Query: 132 STATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI 191
T I + + D NDN P FS+ Y V++ ED V + ++ ATD D G N+ I Y+
Sbjct: 224 GTTQIRIKVTDANDNPPVFSQDVYRVTLRED--VPPGFFVLQVTATDRDEGINAEITYSF 281
Query: 192 IGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
+ Q++ F+++ +G+++ LD+E SY L I A+D G + + Q + I D
Sbjct: 282 HNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQ--VEILD 339
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
ND AP + + E+ P G I ++ D D G N E+ Y GN +
Sbjct: 340 DNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEV-YCQV----LGNAKFIL 394
Query: 310 TIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
++ + + T G LDRE +Y L +TATDGG PP S++ F
Sbjct: 395 KSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQ 454
Query: 369 GQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR--FSITSQNGR-GLI 423
Y V +AE+ PPG + ++A+D D ++ Y I + + R S S + + G++
Sbjct: 455 TSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVV 514
Query: 424 TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAP-VFENA--PYTASV 478
+ D +Q R + LT+ A D G + +A V + + D N+ AP V A P +++
Sbjct: 515 FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSAL 574
Query: 479 FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
F+ P G V V A D+D G NA ++Y + A F + +TG +
Sbjct: 575 FDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ-------ASEPGLFSLGLRTGEVR 627
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
T + L + L V RDGG P LS T + + D
Sbjct: 628 TARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFAD 666
Score = 161 bits (391), Expect = 3e-38
Identities = 136/472 (28%), Positives = 214/472 (45%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+I V D ND+ PVF Y ++RE G VL + ATD+D G NAE+ Y+ V
Sbjct: 229 RIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQ- 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+ F ++ ++G + T+ LD E + YT+ ++A D
Sbjct: 288 ----------------VKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGD----- 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
L++ +I V I+DDND P+ + + + ED VIA IK D D G N + Y
Sbjct: 327 LAAHCSIQVEILDDNDCAPEVIVTSVSTPLPED--SPPGTVIALIKTRDRDSGENGEV-Y 383
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+ GN +F + S S + + T LD E++ Y L I A DGG P S++ + ++
Sbjct: 384 CQVLGNA--KFILKSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLH 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I DVNDNAP F + + V+EN P G SI ++ A D D G + +++Y++ D
Sbjct: 442 ISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREI 501
Query: 307 LP-ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
L +++ +SG V+ D E ++L + A D G P SA +
Sbjct: 502 LSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPR 561
Query: 366 FM-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ P G L + P PG V + A DAD + L Y + + G FS+
Sbjct: 562 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
+ G + A+ L + R L V+ D G +A +++ A++ V
Sbjct: 622 RTGE--VRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEV 671
Score = 133 bits (322), Expect = 8e-30
Identities = 93/283 (32%), Positives = 134/283 (47%), Gaps = 12/283 (4%)
Query: 517 VAHHDQQFVINPQTGAITTNKLLDRETMSG-YLLTVTARDGGVPSLSDTTDVEISVVDVN 575
V+ + F +NP++G + + +DRE + G L V D + + + + V D+N
Sbjct: 68 VSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDIN 127
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFVI 632
DN P+FKQ I E GT+ A D+DVG N Y L+ D E
Sbjct: 128 DNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPD 187
Query: 633 DPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL 692
+ +LDRE + H L A+DGG PPQS T + IK+ D ND+PPVF D
Sbjct: 188 GRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVY 247
Query: 693 TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVT 750
+ E+ P G + ++ A D DEG NA + YS D+ + F+L + G E+ T
Sbjct: 248 RVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTG----EITT 303
Query: 751 MVDLDYESPRKKYELVIRAASP-PLWNDVRVEILVTDVNDNAP 792
DLD+E Y L I A P L +++ + D ND AP
Sbjct: 304 KDDLDFEI-ASSYTLSIEAKDPGDLAAHCSIQVEILDDNDCAP 345
>AB006756-1|BAA25195.1| 1072|Homo sapiens PCDH7 (BH-Pcdh)b protein.
Length = 1072
Score = 245 bits (600), Expect = 2e-63
Identities = 177/590 (30%), Positives = 282/590 (47%), Gaps = 35/590 (5%)
Query: 173 KIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVK-TLDYEQVRSYRLVIRAQD 231
++ A++ G N R ++ Q+ + D +VK LD EQ SY L +R +D
Sbjct: 225 RLDASEGGGGTNPGGRSSVF--ELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRD 282
Query: 232 GGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAE 291
GG P RS+ L + I DVNDN+PRF S+++ ++EN G I++++A D D GVN +
Sbjct: 283 GGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQ 342
Query: 292 LTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATAT 351
+ Y T +V + +D SGW+ ++DRE + + V A D G PP++ AT
Sbjct: 343 IEYVFGAA--TESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKAT 400
Query: 352 XXXXXXXXXXXXXXF-------MPGQYEV-ELAEDEPPGTPVVTLTATDADE-DNRLHYE 402
+P + V +AED TP+ + +D D+ +N +
Sbjct: 401 VVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTC 460
Query: 403 ITGGNTRGRFSITS-----QNGRG-LITVAQPLDFKQERRYVLTVSATDSGGRSDTA--M 454
G+ + S QN + + + PLD++ R + + + A DSG S ++
Sbjct: 461 TVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSKNS 520
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
+ + + D N+ P+F + E+ G V V ATD+D G NA+I YSL S +
Sbjct: 521 LIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMG 580
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
F I+P +G I N +LDRE Y V A+D G+P L +T V + V D
Sbjct: 581 --------IFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADK 632
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN+P F Q ++T + E+ + V V DAD G N + + + F I+
Sbjct: 633 NDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYI---EENNNIFSIEN 689
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I + + DRE T+ + A+DGG PP+S+T V + + D ND+ P
Sbjct: 690 DTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNIS 749
Query: 695 Y--ISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
Y + +S + T + + A D D+G NA ++YSI GG+ F ++ G
Sbjct: 750 YTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSG 799
Score = 232 bits (567), Expect = 2e-59
Identities = 171/566 (30%), Positives = 256/566 (45%), Gaps = 22/566 (3%)
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G LDRE + Y+L + DGGDPPRS+ A F YE +LAE+ P
Sbjct: 264 GALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAP 323
Query: 382 GTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GTP++ L A D D + ++ Y R + G ++V +D ++ +
Sbjct: 324 GTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRF 383
Query: 440 TVSATDSGG--RSDTAMVQINITDANNYAPVFE-----NAPY---TASVFEDAPIGTTVL 489
TV A D G ++D A V +NI D N+ P E P A+V ED + T +
Sbjct: 384 TVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIA 443
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
+V +D D G N +T ++ ++ + D + N + + T+ LD E + +
Sbjct: 444 LVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNV 503
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
+ A D G PSLS + + V D NDN P+F Q + E+ + G V+ V ATDAD
Sbjct: 504 VIVAVDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDAD 563
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N I Y LD G F IDP SG I N LDRE ++ K A D G P
Sbjct: 564 SGKNAEIAYSLD--SSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQG 621
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
+ V +++ D ND+ P F D TFY+ EN + +G + D D+G NA + I+
Sbjct: 622 STTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIE-- 679
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVND 789
+++N FS+E G+ + + D ++++ + PP V + V D ND
Sbjct: 680 ENNNIFSIENDTGTIYSTM--SFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDEND 737
Query: 790 NAP-VMKDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNANLILLNET 845
NAP V I + V V A D+D + L Y I+ GN L ++ T
Sbjct: 738 NAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPT 797
Query: 846 TGSMTLSPQLNTNVPKLATMEVSVTD 871
+G ++L +L L + V V D
Sbjct: 798 SGVVSLVGKLTQKHYGLHRLVVQVND 823
Score = 227 bits (555), Expect = 4e-58
Identities = 182/596 (30%), Positives = 262/596 (43%), Gaps = 57/596 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ + D ND+SP FE YEA + E ++ GT +L L+A D D+G N ++EY T
Sbjct: 295 RVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATES- 353
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+ + R+D SG L +DRE+V + V A D+ P
Sbjct: 354 ----------------VRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPK-- 395
Query: 130 LSSTATIHVNIIDDNDNYPQFSE--------KTYTVSVDEDISVTDNPVIAKIKATDADV 181
+ AT+ +NI D+NDN P K +V ED+ V D P IA ++ +D D
Sbjct: 396 -TDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLV-DTP-IALVQVSDRDQ 452
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVK-------TLDYEQVRSYRLVIRAQDGGS 234
G N + ++G GD + K LDYE R + +VI A D GS
Sbjct: 453 GENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGS 512
Query: 235 PSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTY 294
PS S+ L++ + D NDN P F S+ + EN G + V A DAD G NAE+ Y
Sbjct: 513 PSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAY 572
Query: 295 TMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
++ D G IDP SG + + LDRE +Y+ V A D G P + T
Sbjct: 573 SL-DSSVMG----IFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIV 627
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSI 414
FM + + E+ P +PV +T DAD+ + FSI
Sbjct: 628 QVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSI 687
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVF--- 469
+N G I D + + Y V A D G RS TA V + + D N+ AP
Sbjct: 688 --ENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLP 745
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+N YT + + + T V V ATDSD GINA + YS+ + + F I+P
Sbjct: 746 KNISYTL-LPPSSNVRTVVATVLATDSDDGINADLNYSIVG-------GNPFKLFEIDPT 797
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
+G ++ L ++ + L V D G PS S TT V + V + N Q+
Sbjct: 798 SGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTVVHVFVNESVSNATAIDSQI 853
Score = 220 bits (538), Expect = 5e-56
Identities = 177/601 (29%), Positives = 274/601 (45%), Gaps = 39/601 (6%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + +LDRE+ Y + ++ D P SS A + V I D NDN P+F + Y
Sbjct: 260 LIVKGALDREQRDSYELTLRVRDGGDPPR---SSQAILRVLITDVNDNSPRFEKSVYEAD 316
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQ---FSIDSLSGDVSLVKTL 215
+ E+ S P++ +++A D DVG N I Y + G T+ +D SG +S++ +
Sbjct: 317 LAEN-SAPGTPIL-QLRAADLDVGVNGQIEY-VFGAATESVRRLLRLDETSGWLSVLHRI 373
Query: 216 DYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE--------SVS 267
D E+V R + A+D G P +++ +++NI+D NDN P +V+
Sbjct: 374 DREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVA 433
Query: 268 ENVPIGYSIVRVQAYDADEGVNAELTYTMTDK---DYTGNVDLPITIDPRSGWVYTSGQL 324
E+V + I VQ D D+G N +T T+ D + + +++TS L
Sbjct: 434 EDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPL 493
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E ++ +++ A D G P S+ + F EV E+ PG
Sbjct: 494 DYEATREFNVVIVAVDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGER 553
Query: 385 VVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
V T+ ATDAD + + G F+I +G L+ LD +Q RY V+A
Sbjct: 554 VATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTV--LDREQTDRYEFKVNA 611
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D G + V + + D N+ P F +T V E+ + V +V+ D+D G N
Sbjct: 612 KDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRN 671
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
A++ SL E +N F I TG I + DRE + Y V A DGG P
Sbjct: 672 AEM--SLYIEENNNI-------FSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPR 722
Query: 562 SDTTDVEISVVDVNDNEPVF---KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S T V + V+D NDN P K YT + + V T V+ V ATD+D G+N ++Y
Sbjct: 723 SATATVSLFVMDENDNAPTVTLPKNISYTL-LPPSSNVRTVVATVLATDSDDGINADLNY 781
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
+ + + F IDP SGV+ L ++ H L D G P QS+T +VH+ +
Sbjct: 782 SIVGGNPFK-LFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTVVHVFVN 840
Query: 679 D 679
+
Sbjct: 841 E 841
Score = 176 bits (429), Expect = 8e-43
Identities = 138/473 (29%), Positives = 217/473 (45%), Gaps = 38/473 (8%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ V LD +Q Y LT+ D G RS A++++ ITD N+ +P FE + Y A + E
Sbjct: 260 LIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAE 319
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
++ GT +L + A D DVG+N QI Y + + E+V + ++ +G ++ +D
Sbjct: 320 NSAPGTPILQLRAADLDVGVNGQIEYVFGA--ATESVR---RLLRLDETSGWLSVLHRID 374
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLY--------TANIME 592
RE ++ TV ARD G P +D V +++ D NDN P + + AN+ E
Sbjct: 375 REEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAE 434
Query: 593 DALVGTSVSQVGATDADVGLNG--------RIHYELDPKDREEGSFVIDPASGVIRTNKA 644
D LV T ++ V +D D G NG + ++L P EG + + T+
Sbjct: 435 DVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ--NKKKYFLHTSTP 492
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
LD E+ ++ VA+D G+P SS + +K+ D ND+PP+F + Y EN+ G
Sbjct: 493 LDYEATREFNVVIVAVDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGE 552
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
+ + A D D G NA + YS+ DS+ + D +++ LD E +YE
Sbjct: 553 RVATVLATDADSGKNAEIAYSL----DSSVMGIFAID-PDSGDILVNTVLDREQT-DRYE 606
Query: 765 LVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNY--KDCFPVGPFGRVPAY 819
+ A P L V + V D NDN P K Q +F Y ++ P P G V
Sbjct: 607 FKVNAKDKGIPVLQGSTTVIVQVADKNDNDP--KFMQDVFTFYVKENLQPNSPVGMVTVM 664
Query: 820 DADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
DAD + + N N+ + TG++ + + T V DG
Sbjct: 665 DADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDG 717
Score = 46.0 bits (104), Expect = 0.002
Identities = 25/65 (38%), Positives = 33/65 (50%)
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGR 615
G S D + ++ V+D+NDN P F + T + E+ VGT ATD D G NG
Sbjct: 118 GPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGI 177
Query: 616 IHYEL 620
YEL
Sbjct: 178 ERYEL 182
Score = 42.3 bits (95), Expect = 0.024
Identities = 21/56 (37%), Positives = 30/56 (53%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSE 511
Q+ + D N+ P F + T +V E+ P+GT L+ +ATD D G N Y L E
Sbjct: 130 QVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQE 185
Score = 41.5 bits (93), Expect = 0.042
Identities = 20/48 (41%), Positives = 25/48 (52%)
Query: 679 DINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
DIND+ P F S LT + EN P+GT A D D G N + Y +
Sbjct: 135 DINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYEL 182
Score = 40.3 bits (90), Expect = 0.097
Identities = 20/53 (37%), Positives = 27/53 (50%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
Q+ VLD ND++P F +V E GT L ATD+D G+N Y +
Sbjct: 130 QVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYEL 182
Score = 36.3 bits (80), Expect = 1.6
Identities = 32/144 (22%), Positives = 67/144 (46%), Gaps = 16/144 (11%)
Query: 167 DNPVIAKIKATDADVG---ANSAIRYAIIGGNTQMQFSIDSLSGDVSLV-KTLDYEQVRS 222
+ P +I +D+G + + +++ G+ ++ ID+L+G++S + +D E++
Sbjct: 41 EGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLK--IDNLTGELSTSERRIDREKLPQ 98
Query: 223 YRLVIRAQD----------GGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
+++ + G S S + + + + D+NDN P F + + +V EN P+
Sbjct: 99 CQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPV 158
Query: 273 GYSIVRVQAYDADEGVNAELTYTM 296
G + A D D G N Y +
Sbjct: 159 GTLYLLPTATDRDFGRNGIERYEL 182
Score = 34.7 bits (76), Expect = 4.8
Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 10/113 (8%)
Query: 88 DVFRIDGRSGALLT-RASLDREKVARYTVLVKATD-----QASPVSDRLSSTATIH--VN 139
+ +ID +G L T +DREK+ + ++ + + S + S V
Sbjct: 73 EYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVI 132
Query: 140 IIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII 192
++D NDN P F T++V+E+ V + ATD D G N RY ++
Sbjct: 133 VLDINDNTPTFPSPVLTLTVEENRPV--GTLYLLPTATDRDFGRNGIERYELL 183
>AB006755-1|BAA25194.1| 1069|Homo sapiens PCDH7 (BH-Pcdh)a protein.
Length = 1069
Score = 245 bits (600), Expect = 2e-63
Identities = 177/590 (30%), Positives = 282/590 (47%), Gaps = 35/590 (5%)
Query: 173 KIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVK-TLDYEQVRSYRLVIRAQD 231
++ A++ G N R ++ Q+ + D +VK LD EQ SY L +R +D
Sbjct: 225 RLDASEGGGGTNPGGRSSVF--ELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRD 282
Query: 232 GGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAE 291
GG P RS+ L + I DVNDN+PRF S+++ ++EN G I++++A D D GVN +
Sbjct: 283 GGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQ 342
Query: 292 LTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATAT 351
+ Y T +V + +D SGW+ ++DRE + + V A D G PP++ AT
Sbjct: 343 IEYVFGAA--TESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKAT 400
Query: 352 XXXXXXXXXXXXXXF-------MPGQYEV-ELAEDEPPGTPVVTLTATDADE-DNRLHYE 402
+P + V +AED TP+ + +D D+ +N +
Sbjct: 401 VVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTC 460
Query: 403 ITGGNTRGRFSITS-----QNGRG-LITVAQPLDFKQERRYVLTVSATDSGGRSDTA--M 454
G+ + S QN + + + PLD++ R + + + A DSG S ++
Sbjct: 461 TVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSKNS 520
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
+ + + D N+ P+F + E+ G V V ATD+D G NA+I YSL S +
Sbjct: 521 LIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMG 580
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
F I+P +G I N +LDRE Y V A+D G+P L +T V + V D
Sbjct: 581 --------IFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADK 632
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDP 634
NDN+P F Q ++T + E+ + V V DAD G N + + + F I+
Sbjct: 633 NDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYI---EENNNIFSIEN 689
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G I + + DRE T+ + A+DGG PP+S+T V + + D ND+ P
Sbjct: 690 DTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNIS 749
Query: 695 Y--ISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
Y + +S + T + + A D D+G NA ++YSI GG+ F ++ G
Sbjct: 750 YTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSG 799
Score = 232 bits (567), Expect = 2e-59
Identities = 171/566 (30%), Positives = 256/566 (45%), Gaps = 22/566 (3%)
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G LDRE + Y+L + DGGDPPRS+ A F YE +LAE+ P
Sbjct: 264 GALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAP 323
Query: 382 GTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GTP++ L A D D + ++ Y R + G ++V +D ++ +
Sbjct: 324 GTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRF 383
Query: 440 TVSATDSGG--RSDTAMVQINITDANNYAPVFE-----NAPY---TASVFEDAPIGTTVL 489
TV A D G ++D A V +NI D N+ P E P A+V ED + T +
Sbjct: 384 TVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIA 443
Query: 490 VVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLL 549
+V +D D G N +T ++ ++ + D + N + + T+ LD E + +
Sbjct: 444 LVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNV 503
Query: 550 TVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDAD 609
+ A D G PSLS + + V D NDN P+F Q + E+ + G V+ V ATDAD
Sbjct: 504 VIVAVDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDAD 563
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N I Y LD G F IDP SG I N LDRE ++ K A D G P
Sbjct: 564 SGKNAEIAYSLD--SSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQG 621
Query: 670 TVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGG 729
+ V +++ D ND+ P F D TFY+ EN + +G + D D+G NA + I+
Sbjct: 622 STTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIE-- 679
Query: 730 DDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVND 789
+++N FS+E G+ + + D ++++ + PP V + V D ND
Sbjct: 680 ENNNIFSIENDTGTIYSTM--SFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDEND 737
Query: 790 NAP-VMKDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNANLILLNET 845
NAP V I + V V A D+D + L Y I+ GN L ++ T
Sbjct: 738 NAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPT 797
Query: 846 TGSMTLSPQLNTNVPKLATMEVSVTD 871
+G ++L +L L + V V D
Sbjct: 798 SGVVSLVGKLTQKHYGLHRLVVQVND 823
Score = 227 bits (555), Expect = 4e-58
Identities = 182/596 (30%), Positives = 262/596 (43%), Gaps = 57/596 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ + D ND+SP FE YEA + E ++ GT +L L+A D D+G N ++EY T
Sbjct: 295 RVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATES- 353
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+ + R+D SG L +DRE+V + V A D+ P
Sbjct: 354 ----------------VRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPK-- 395
Query: 130 LSSTATIHVNIIDDNDNYPQFSE--------KTYTVSVDEDISVTDNPVIAKIKATDADV 181
+ AT+ +NI D+NDN P K +V ED+ V D P IA ++ +D D
Sbjct: 396 -TDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLV-DTP-IALVQVSDRDQ 452
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVK-------TLDYEQVRSYRLVIRAQDGGS 234
G N + ++G GD + K LDYE R + +VI A D GS
Sbjct: 453 GENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGS 512
Query: 235 PSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTY 294
PS S+ L++ + D NDN P F S+ + EN G + V A DAD G NAE+ Y
Sbjct: 513 PSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAY 572
Query: 295 TMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
++ D G IDP SG + + LDRE +Y+ V A D G P + T
Sbjct: 573 SL-DSSVMG----IFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIV 627
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSI 414
FM + + E+ P +PV +T DAD+ + FSI
Sbjct: 628 QVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSI 687
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVF--- 469
+N G I D + + Y V A D G RS TA V + + D N+ AP
Sbjct: 688 --ENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLP 745
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+N YT + + + T V V ATDSD GINA + YS+ + + F I+P
Sbjct: 746 KNISYTL-LPPSSNVRTVVATVLATDSDDGINADLNYSIVG-------GNPFKLFEIDPT 797
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQL 585
+G ++ L ++ + L V D G PS S TT V + V + N Q+
Sbjct: 798 SGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTVVHVFVNESVSNATAIDSQI 853
Score = 220 bits (538), Expect = 5e-56
Identities = 177/601 (29%), Positives = 274/601 (45%), Gaps = 39/601 (6%)
Query: 99 LLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVS 158
L+ + +LDRE+ Y + ++ D P SS A + V I D NDN P+F + Y
Sbjct: 260 LIVKGALDREQRDSYELTLRVRDGGDPPR---SSQAILRVLITDVNDNSPRFEKSVYEAD 316
Query: 159 VDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQ---FSIDSLSGDVSLVKTL 215
+ E+ S P++ +++A D DVG N I Y + G T+ +D SG +S++ +
Sbjct: 317 LAEN-SAPGTPIL-QLRAADLDVGVNGQIEY-VFGAATESVRRLLRLDETSGWLSVLHRI 373
Query: 216 DYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE--------SVS 267
D E+V R + A+D G P +++ +++NI+D NDN P +V+
Sbjct: 374 DREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVA 433
Query: 268 ENVPIGYSIVRVQAYDADEGVNAELTYTMTDK---DYTGNVDLPITIDPRSGWVYTSGQL 324
E+V + I VQ D D+G N +T T+ D + + +++TS L
Sbjct: 434 EDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPL 493
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E ++ +++ A D G P S+ + F EV E+ PG
Sbjct: 494 DYEATREFNVVIVAVDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGER 553
Query: 385 VVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
V T+ ATDAD + + G F+I +G L+ LD +Q RY V+A
Sbjct: 554 VATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTV--LDREQTDRYEFKVNA 611
Query: 444 TDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
D G + V + + D N+ P F +T V E+ + V +V+ D+D G N
Sbjct: 612 KDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRN 671
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
A++ SL E +N F I TG I + DRE + Y V A DGG P
Sbjct: 672 AEM--SLYIEENNNI-------FSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPR 722
Query: 562 SDTTDVEISVVDVNDNEPVF---KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY 618
S T V + V+D NDN P K YT + + V T V+ V ATD+D G+N ++Y
Sbjct: 723 SATATVSLFVMDENDNAPTVTLPKNISYTL-LPPSSNVRTVVATVLATDSDDGINADLNY 781
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
+ + + F IDP SGV+ L ++ H L D G P QS+T +VH+ +
Sbjct: 782 SIVGGNPFK-LFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTVVHVFVN 840
Query: 679 D 679
+
Sbjct: 841 E 841
Score = 176 bits (429), Expect = 8e-43
Identities = 138/473 (29%), Positives = 217/473 (45%), Gaps = 38/473 (8%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ V LD +Q Y LT+ D G RS A++++ ITD N+ +P FE + Y A + E
Sbjct: 260 LIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAE 319
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
++ GT +L + A D DVG+N QI Y + + E+V + ++ +G ++ +D
Sbjct: 320 NSAPGTPILQLRAADLDVGVNGQIEYVFGA--ATESVR---RLLRLDETSGWLSVLHRID 374
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLY--------TANIME 592
RE ++ TV ARD G P +D V +++ D NDN P + + AN+ E
Sbjct: 375 REEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAE 434
Query: 593 DALVGTSVSQVGATDADVGLNG--------RIHYELDPKDREEGSFVIDPASGVIRTNKA 644
D LV T ++ V +D D G NG + ++L P EG + + T+
Sbjct: 435 DVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ--NKKKYFLHTSTP 492
Query: 645 LDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGT 704
LD E+ ++ VA+D G+P SS + +K+ D ND+PP+F + Y EN+ G
Sbjct: 493 LDYEATREFNVVIVAVDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGE 552
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYE 764
+ + A D D G NA + YS+ DS+ + D +++ LD E +YE
Sbjct: 553 RVATVLATDADSGKNAEIAYSL----DSSVMGIFAID-PDSGDILVNTVLDREQT-DRYE 606
Query: 765 LVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNY--KDCFPVGPFGRVPAY 819
+ A P L V + V D NDN P K Q +F Y ++ P P G V
Sbjct: 607 FKVNAKDKGIPVLQGSTTVIVQVADKNDNDP--KFMQDVFTFYVKENLQPNSPVGMVTVM 664
Query: 820 DADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
DAD + + N N+ + TG++ + + T V DG
Sbjct: 665 DADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDG 717
Score = 46.0 bits (104), Expect = 0.002
Identities = 25/65 (38%), Positives = 33/65 (50%)
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGR 615
G S D + ++ V+D+NDN P F + T + E+ VGT ATD D G NG
Sbjct: 118 GPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGI 177
Query: 616 IHYEL 620
YEL
Sbjct: 178 ERYEL 182
Score = 42.3 bits (95), Expect = 0.024
Identities = 21/56 (37%), Positives = 30/56 (53%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSE 511
Q+ + D N+ P F + T +V E+ P+GT L+ +ATD D G N Y L E
Sbjct: 130 QVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQE 185
Score = 41.5 bits (93), Expect = 0.042
Identities = 20/48 (41%), Positives = 25/48 (52%)
Query: 679 DINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI 726
DIND+ P F S LT + EN P+GT A D D G N + Y +
Sbjct: 135 DINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYEL 182
Score = 40.3 bits (90), Expect = 0.097
Identities = 20/53 (37%), Positives = 27/53 (50%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
Q+ VLD ND++P F +V E GT L ATD+D G+N Y +
Sbjct: 130 QVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYEL 182
Score = 36.3 bits (80), Expect = 1.6
Identities = 32/144 (22%), Positives = 67/144 (46%), Gaps = 16/144 (11%)
Query: 167 DNPVIAKIKATDADVG---ANSAIRYAIIGGNTQMQFSIDSLSGDVSLV-KTLDYEQVRS 222
+ P +I +D+G + + +++ G+ ++ ID+L+G++S + +D E++
Sbjct: 41 EGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLK--IDNLTGELSTSERRIDREKLPQ 98
Query: 223 YRLVIRAQD----------GGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPI 272
+++ + G S S + + + + D+NDN P F + + +V EN P+
Sbjct: 99 CQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPV 158
Query: 273 GYSIVRVQAYDADEGVNAELTYTM 296
G + A D D G N Y +
Sbjct: 159 GTLYLLPTATDRDFGRNGIERYEL 182
Score = 34.7 bits (76), Expect = 4.8
Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 10/113 (8%)
Query: 88 DVFRIDGRSGALLT-RASLDREKVARYTVLVKATD-----QASPVSDRLSSTATIH--VN 139
+ +ID +G L T +DREK+ + ++ + + S + S V
Sbjct: 73 EYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVI 132
Query: 140 IIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAII 192
++D NDN P F T++V+E+ V + ATD D G N RY ++
Sbjct: 133 VLDINDNTPTFPSPVLTLTVEENRPV--GTLYLLPTATDRDFGRNGIERYELL 183
>AF169693-1|AAF89690.1| 947|Homo sapiens protocadherin 13 protein.
Length = 947
Score = 243 bits (595), Expect = 6e-63
Identities = 186/669 (27%), Positives = 303/669 (45%), Gaps = 28/669 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
+ + I D NDN PQF +V V E+ V I A D DVG N Y ++ +
Sbjct: 191 VKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEH-PAVDPDVGINGVQTYRLLDYH 249
Query: 196 TQMQFSID-SLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
++ + +G+ + ++ LD E Y +I A+DGGSP + L I I D+
Sbjct: 250 GMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIITAEDGGSPPLLGSATLTIGISDI 309
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F S +V N +G I VQA D D G NA++TY+ + K + DL
Sbjct: 310 NDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDL-FH 368
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXX--XXXXXFMP 368
+D +G + ++ ++L + A G P TA ++
Sbjct: 369 LDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIA 428
Query: 369 GQYE--VELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVA 426
+ + V L E EP TP+ T D + +++ + G N L+
Sbjct: 429 NEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETT 488
Query: 427 QPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGT 486
+P+D++ ++ Y + V A +S G ++++ + D N+ AP+F ++ E+
Sbjct: 489 KPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNA 548
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
+ + ATD+D Q++Y L + + F ++ TG +T + LDRE
Sbjct: 549 FLTKLYATDADSEERGQVSYFLGPDAPS--------YFSLDSVTGILTVSTQLDREEKEK 600
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
Y TV A D G P V ++V+D NDN P F + ++ + E+ + + T
Sbjct: 601 YRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVT 660
Query: 607 DADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
DAD G NG + + + FVID G++R +LDRE +++ L A+DGG P
Sbjct: 661 DADAGRNGWVALSV---VNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 717
Query: 667 QSSTVIVHIKIEDINDSPP--VFESDCLTFYISENSPI-GTTIGEIRAHDPDEGPNAVVH 723
SST + I + DIND+PP +F +++ + S + G+ + E+ A D D G NAV+
Sbjct: 718 LSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIA 777
Query: 724 YSIKG--GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVE 781
YSI G G SF ++ + G+ E ++ DY R ++ PL + V V
Sbjct: 778 YSIIGRRGPRPESFRIDPKTGNITLE-EALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVN 836
Query: 782 ILVTDVNDN 790
+ V D N
Sbjct: 837 LFVNDTVSN 845
Score = 183 bits (445), Expect = 9e-45
Identities = 191/703 (27%), Positives = 302/703 (42%), Gaps = 66/703 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTV-LTLKATDQDIGKNAEVEYTI-ELVTA 67
+I + D ND++P F + Q V E A T + + A D D+G N Y + +
Sbjct: 192 KIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGM 251
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
TL+ E+ R+ L+ +LDRE +Y ++ A D SP
Sbjct: 252 FTLDVEENENGE---------------RTPYLIVMGALDRETQDQYVSIITAEDGGSPP- 295
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L +AT+ + I D NDN P F++ V+V + +V IA ++A D D+G N+ I
Sbjct: 296 --LLGSATLTIGISDINDNCPLFTDSQINVTVYGNATV--GTPIAAVQAVDKDLGTNAQI 351
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQL 243
Y+ + ++ F +D +G + L + + S++L I A G P+
Sbjct: 352 TYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVS 411
Query: 244 LIN-IRDVNDNAPRFYTS------LFQESVSENVPIGYSIVR--VQAYDADEGVNAELTY 294
+I I + PR+ + +E N PI + +R Y + ++ E +
Sbjct: 412 IIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPF 471
Query: 295 TMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
++ N L T P +D E Q Y++ V A +
Sbjct: 472 RLSPYKPYNNEYLLETTKP----------MDYELQQFYEVAVVAWN--SEGFHVKRVIKV 519
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFS 413
F+ E+ + E+ P + L ATDAD + R G + FS
Sbjct: 520 QLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFS 579
Query: 414 ITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFEN 471
+ S G++TV+ LD +++ +Y TV A D G R A V + + D N+ +P F N
Sbjct: 580 LDSVT--GILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFIN 637
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
++ V E+ P + V+S TD+D G N + S V + FVI+ G
Sbjct: 638 KDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALS---------VVNQSDIFVIDTGKG 688
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP--VFKQ-QLYTA 588
+ LDRE S Y L V A DGG P+LS T + I ++D+NDN P +F Q +
Sbjct: 689 MLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYL 748
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYE-LDPKDREEGSFVIDPASGVIRTNKALDR 647
++ L G+ V++V A D D G+N I Y + + SF IDP +G I +AL +
Sbjct: 749 LVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQ 808
Query: 648 ESVATHDLKAVAIDGGTP-PQSSTVIVHIKIEDINDSPPVFES 689
H L D G P P STV+V++ + D + ES
Sbjct: 809 TDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIES 851
Score = 171 bits (416), Expect = 3e-41
Identities = 167/647 (25%), Positives = 272/647 (42%), Gaps = 37/647 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADEGVNAELTYTMTDKDYTG 303
I IRD+NDNAP+F S V EN P+ + + A D D G+N TY + D Y G
Sbjct: 193 IAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLD--YHG 250
Query: 304 NVDLPITIDP---RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXX 360
L + + R+ ++ G LDRETQ +Y ++TA DGG PP +AT
Sbjct: 251 MFTLDVEENENGERTPYLIVMGALDRETQDQYVSIITAEDGGSPPLLGSATLTIGISDIN 310
Query: 361 XXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITS-Q 417
F Q V + + GTP+ + A D D + ++ Y + + +
Sbjct: 311 DNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLD 370
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQIN--ITDANNYAPVFENAP 473
G+I + + + LT+ A G TA+V I I P +
Sbjct: 371 ENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANE 430
Query: 474 YTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
V+ E P+ T + + D + Y ++ + E N +
Sbjct: 431 IDGVVYLKELEPVNTPIAFFTIRDPEG------KYKVNCYLDGEGPFRLSPYKPYNNEY- 483
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
+ T K +D E Y + V A + +++ ++D NDN P+F Q L I
Sbjct: 484 LLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIE 541
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVA 651
E+ ++++ ATDAD G++ Y L P F +D +G++ + LDRE
Sbjct: 542 ENNSPNAFLTKLYATDADSEERGQVSYFLGPD--APSYFSLDSVTGILTVSTQLDREEKE 599
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
+ A+D G PP+ S V + + D ND+ P F + +F++ EN P IG I
Sbjct: 600 KYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISV 659
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS 771
D D G N V S+ + S+ F ++T +G +A++ +D + +S + +
Sbjct: 660 TDADAGRNGWVALSVV--NQSDIFVIDTGKGMLRAKV--SLDREQQSSYTLWVEAVDGGE 715
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN---YKDCFPVGPFGRVPAYDAD--VTDK 826
P L + ++ IL+ D+NDN P++ Q + P P V A D D +
Sbjct: 716 PALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAV 775
Query: 827 LQYRILS--GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ Y I+ G ++ TG++TL L L + V V+D
Sbjct: 776 IAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSD 822
Score = 89.8 bits (213), Expect = 1e-16
Identities = 78/266 (29%), Positives = 126/266 (47%), Gaps = 33/266 (12%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F + + V E + + TD D G+N V ++ +
Sbjct: 623 LTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSV-------V 675
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D +F ID G L + SLDRE+ + YT+ V+A D P L
Sbjct: 676 NQSD--------------IFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA---L 718
Query: 131 SSTATIHVNIIDDNDNYP--QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
SSTA I + ++D NDN P F + + + ++ +PV ++ A D D G N+ I
Sbjct: 719 SSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPV-TEVYAVDKDTGMNAVIA 777
Query: 189 YAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+IIG G F ID +G+++L + L +RL+++ D G P ++T +++N
Sbjct: 778 YSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHST-VMVN 836
Query: 247 IRDVNDNAPR--FYTSLFQESVSENV 270
+ VND + SL ++ N+
Sbjct: 837 L-FVNDTVSNESYIESLLRKEPEINI 861
Score = 77.4 bits (182), Expect = 7e-13
Identities = 64/227 (28%), Positives = 107/227 (47%), Gaps = 12/227 (5%)
Query: 671 VIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDEGPNAVVHYSIKGG 729
V V I I DIND+ P F ++ ++ EN+P+ T + E A DPD G N V Y +
Sbjct: 189 VKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDY 248
Query: 730 DDSNSFSLETRQGSDKAE-LVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVT 785
+ +E + ++ L+ M LD E+ + +Y +I A SPPL + I ++
Sbjct: 249 HGMFTLDVEENENGERTPYLIVMGALDRET-QDQYVSIITAEDGGSPPLLGSATLTIGIS 307
Query: 786 DVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQY-----RILSGNNANLI 840
D+NDN P+ D QI Y + P V A D D+ Q + + + +L
Sbjct: 308 DINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLF 367
Query: 841 LLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLI 887
L+E TG + L ++ +V + + + + +G I A++ V +I
Sbjct: 368 HLDENTGVIKLFSKIGGSVLESHKLTI-LANGPGCIPAVITALVSII 413
>BC003126-1|AAH03126.1| 808|Homo sapiens protocadherin alpha 2
protein.
Length = 808
Score = 243 bits (594), Expect = 8e-63
Identities = 181/614 (29%), Positives = 285/614 (46%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHVEVIVDRPLQVFHVEVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDS 204
P F T+ E + D+ + A+DAD+G N+ + Y + +Q + D
Sbjct: 131 PIFPMTVKTIRFPES-RLLDSRFPLE-GASDADIGVNALLSYKLSSSEFFFLDIQAN-DE 187
Query: 205 LSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
LS +SLV K+LD E+ L++ A DGG P + T Q+LI + DVNDN P F S++
Sbjct: 188 LSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ + EN G +V++ A DADEG N+E+ Y++ D + + TIDP SG + T G
Sbjct: 248 KVKLLENTANGTLVVKLNASDADEGPNSEIVYSL-GSDVSSTIQTKFTIDPISGEIRTKG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LD E Y++ VTATD G P S + ++E+ G
Sbjct: 307 KLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLG 366
Query: 383 TPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
T + +T +D D H + + + T +N L+ + LD + Y L V
Sbjct: 367 TVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S T V I + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485
Query: 500 INAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD GV
Sbjct: 486 ENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEEVELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATDADVG 611
P L +++ V+D NDN P + + TA LV G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL F + +G I T +ALD H L + D G P ++T
Sbjct: 603 YNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 217 bits (529), Expect = 6e-55
Identities = 163/549 (29%), Positives = 257/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F ++ E+ + A DAD GVNA L+Y ++ ++
Sbjct: 121 VEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFF- 179
Query: 305 VDLPITIDPRSGWVYTSGQ-LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + G+ LDRE A+ LL+ ATDGG P + T
Sbjct: 180 LDIQANDELSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNE 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI---TGGNTRGRFSITSQN 418
F Y+V+L E+ GT VV L A+DADE ++ + Y + + +F+I +
Sbjct: 240 PTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPIS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G I LD+++ + Y + V+ATD G S + + + D N+ P +
Sbjct: 300 GE--IRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ E+A +GT + +++ +D D G N +T SL+ + + V+ + ++ +
Sbjct: 358 PISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL TT V I V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E V
Sbjct: 471 GCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ G + S + R G E+ T LD +SPR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQLG--TGSARIPFRVGLYTGEISTTRALDEADSPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 192 bits (468), Expect = 2e-47
Identities = 119/377 (31%), Positives = 194/377 (51%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQI--NITDANNYAPVFENAPYTASVFE 480
+ + + LD ++ L + ATD G T VQI + D N+ P F + Y + E
Sbjct: 194 LVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ GT V+ ++A+D+D G N++I YSL S++S+ +F I+P +G I T LD
Sbjct: 254 NTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTI----QTKFTIDPISGEIRTKGKLD 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + VTA D G PS+S + + +VD+NDN P + I E+A +GT +
Sbjct: 310 YEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G NG + L P + ++ + ALDRESV+ ++L A
Sbjct: 370 ALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V I++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENA 488
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWND 777
+V YS ++ + S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 489 LVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSN 548
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 549 VTLQVFVLDENDNAPAL 565
Score = 188 bits (459), Expect = 2e-46
Identities = 144/449 (32%), Positives = 216/449 (48%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSS-EIS 513
V++ + D N+ P+F T E + + + A+D+D+G+NA ++Y LSS E
Sbjct: 119 VEVEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ +D+ ++ ++ K LDRE + L + A DGG P L+ T + I V+D
Sbjct: 179 FLDIQANDEL----SESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
VNDNEP F Q +Y ++E+ GT V ++ A+DAD G N I Y L D + F
Sbjct: 235 VNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFT 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
IDP SG IRT LD E +++++ A D GTP S + +K+ DIND+ P
Sbjct: 295 IDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ ISEN+ +GT I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPISENASLGTVIALITVSDRDSGTNGHVTCSLT---PHVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW V I V DVNDNAP + ++
Sbjct: 411 SALDRESV-SAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPK 861
P V A+DAD + + Y ++ G A + + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 173 bits (420), Expect = 1e-41
Identities = 143/489 (29%), Positives = 218/489 (44%), Gaps = 40/489 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ P F Y+ + E ++GT V+ L A+D D G N+E+ Y++ + T
Sbjct: 230 IKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSST- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+Q F ID SG + T+ LD E+ Y + V ATD+ +P +
Sbjct: 289 ---------------IQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTP---SM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S I + ++D NDN P+ S + ++ + E+ S+ VIA I +D D G N + +
Sbjct: 331 SGHCKISLKLVDINDNTPEVSITSLSLPISENASL--GTVIALITVSDRDSGTNGHVTCS 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS TT + I +
Sbjct: 389 L---TPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
DVNDNAP F + V EN P G I V A+DAD NA ++Y++ ++ +
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 M---PGQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G ++E P G V + A DAD L YE+ G R
Sbjct: 566 LAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ + LD R+ L V D G + TA V +++ ++ AP + +
Sbjct: 626 LYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQ-APKASSRAWV 684
Query: 476 ASVFEDAPI 484
+ +A +
Sbjct: 685 GAAGSEATL 693
Score = 140 bits (338), Expect = 9e-32
Identities = 99/325 (30%), Positives = 155/325 (47%), Gaps = 19/325 (5%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ + L + A H +N Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELE---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN P+F + T E L
Sbjct: 88 SRIDREELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPESRL 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVIRTNKALDRESV 650
+ + GA+DAD+G+N + Y+L D + + + S V+ K+LDRE
Sbjct: 148 LDSRFPLEGASDADIGVNALLSYKLSSSEFFFLDIQANDELSESLSLVL--GKSLDREET 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
A +L VA DGG P + TV + IK+ D+ND+ P F + EN+ GT + ++
Sbjct: 206 AEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLN 265
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA- 769
A D DEGPN+ + YS+ G D S++ + E+ T LDYE K YE+ + A
Sbjct: 266 ASDADEGPNSEIVYSL-GSDVSSTIQTKFTIDPISGEIRTKGKLDYEE-AKSYEIQVTAT 323
Query: 770 --ASPPLWNDVRVEILVTDVNDNAP 792
+P + ++ + + D+NDN P
Sbjct: 324 DKGTPSMSGHCKISLKLVDINDNTP 348
Score = 63.3 bits (147), Expect = 1e-08
Identities = 69/332 (20%), Positives = 147/332 (44%), Gaps = 22/332 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVPEEAKHGTFVGRI-AQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V ++++DIND+PP+F T E+ + +
Sbjct: 93 EELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPESRLLDSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMV---DLDYESPRKKY 763
A D D G NA++ Y + S F L+ + + +E +++V LD E +
Sbjct: 153 PLEGASDADIGVNALLSYKL---SSSEFFFLDIQANDELSESLSLVLGKSLDREETAEVN 209
Query: 764 ELVIR--AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
L++ P L V++ I V DVNDN P ++ ++ A DA
Sbjct: 210 LLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDA 269
Query: 822 D--VTDKLQYRILSGNNANL---ILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNE 875
D ++ Y + S ++ + ++ +G + +L+ K ++V+ TD G
Sbjct: 270 DEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPS 329
Query: 876 IKAMMQLSVRLI-----TEEMLLNSITVRLND 902
+ ++S++L+ T E+ + S+++ +++
Sbjct: 330 MSGHCKISLKLVDINDNTPEVSITSLSLPISE 361
>AF152480-1|AAD43741.1| 824|Homo sapiens protocadherin alpha 2
short form protein protein.
Length = 824
Score = 243 bits (594), Expect = 8e-63
Identities = 181/614 (29%), Positives = 285/614 (46%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHVEVIVDRPLQVFHVEVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDS 204
P F T+ E + D+ + A+DAD+G N+ + Y + +Q + D
Sbjct: 131 PIFPMTVKTIRFPES-RLLDSRFPLE-GASDADIGVNALLSYKLSSSEFFFLDIQAN-DE 187
Query: 205 LSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
LS +SLV K+LD E+ L++ A DGG P + T Q+LI + DVNDN P F S++
Sbjct: 188 LSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ + EN G +V++ A DADEG N+E+ Y++ D + + TIDP SG + T G
Sbjct: 248 KVKLLENTANGTLVVKLNASDADEGPNSEIVYSL-GSDVSSTIQTKFTIDPISGEIRTKG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LD E Y++ VTATD G P S + ++E+ G
Sbjct: 307 KLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLG 366
Query: 383 TPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
T + +T +D D H + + + T +N L+ + LD + Y L V
Sbjct: 367 TVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S T V I + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485
Query: 500 INAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD GV
Sbjct: 486 ENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEEVELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATDADVG 611
P L +++ V+D NDN P + + TA LV G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL F + +G I T +ALD H L + D G P ++T
Sbjct: 603 YNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 217 bits (529), Expect = 6e-55
Identities = 163/549 (29%), Positives = 257/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F ++ E+ + A DAD GVNA L+Y ++ ++
Sbjct: 121 VEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFF- 179
Query: 305 VDLPITIDPRSGWVYTSGQ-LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + G+ LDRE A+ LL+ ATDGG P + T
Sbjct: 180 LDIQANDELSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNE 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI---TGGNTRGRFSITSQN 418
F Y+V+L E+ GT VV L A+DADE ++ + Y + + +F+I +
Sbjct: 240 PTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPIS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G I LD+++ + Y + V+ATD G S + + + D N+ P +
Sbjct: 300 GE--IRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ E+A +GT + +++ +D D G N +T SL+ + + V+ + ++ +
Sbjct: 358 PISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL TT V I V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E V
Sbjct: 471 GCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ G + S + R G E+ T LD +SPR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQLG--TGSARIPFRVGLYTGEISTTRALDEADSPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 192 bits (468), Expect = 2e-47
Identities = 119/377 (31%), Positives = 194/377 (51%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQI--NITDANNYAPVFENAPYTASVFE 480
+ + + LD ++ L + ATD G T VQI + D N+ P F + Y + E
Sbjct: 194 LVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ GT V+ ++A+D+D G N++I YSL S++S+ +F I+P +G I T LD
Sbjct: 254 NTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTI----QTKFTIDPISGEIRTKGKLD 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + VTA D G PS+S + + +VD+NDN P + I E+A +GT +
Sbjct: 310 YEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G NG + L P + ++ + ALDRESV+ ++L A
Sbjct: 370 ALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V I++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENA 488
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWND 777
+V YS ++ + S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 489 LVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSN 548
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 549 VTLQVFVLDENDNAPAL 565
Score = 188 bits (459), Expect = 2e-46
Identities = 144/449 (32%), Positives = 216/449 (48%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSS-EIS 513
V++ + D N+ P+F T E + + + A+D+D+G+NA ++Y LSS E
Sbjct: 119 VEVEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ +D+ ++ ++ K LDRE + L + A DGG P L+ T + I V+D
Sbjct: 179 FLDIQANDEL----SESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
VNDNEP F Q +Y ++E+ GT V ++ A+DAD G N I Y L D + F
Sbjct: 235 VNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFT 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
IDP SG IRT LD E +++++ A D GTP S + +K+ DIND+ P
Sbjct: 295 IDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ ISEN+ +GT I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPISENASLGTVIALITVSDRDSGTNGHVTCSLT---PHVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW V I V DVNDNAP + ++
Sbjct: 411 SALDRESV-SAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPK 861
P V A+DAD + + Y ++ G A + + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 173 bits (420), Expect = 1e-41
Identities = 143/489 (29%), Positives = 218/489 (44%), Gaps = 40/489 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ P F Y+ + E ++GT V+ L A+D D G N+E+ Y++ + T
Sbjct: 230 IKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSST- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+Q F ID SG + T+ LD E+ Y + V ATD+ +P +
Sbjct: 289 ---------------IQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTP---SM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S I + ++D NDN P+ S + ++ + E+ S+ VIA I +D D G N + +
Sbjct: 331 SGHCKISLKLVDINDNTPEVSITSLSLPISENASL--GTVIALITVSDRDSGTNGHVTCS 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS TT + I +
Sbjct: 389 L---TPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
DVNDNAP F + V EN P G I V A+DAD NA ++Y++ ++ +
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 M---PGQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G ++E P G V + A DAD L YE+ G R
Sbjct: 566 LAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ + LD R+ L V D G + TA V +++ ++ AP + +
Sbjct: 626 LYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQ-APKASSRAWV 684
Query: 476 ASVFEDAPI 484
+ +A +
Sbjct: 685 GAAGSEATL 693
Score = 140 bits (338), Expect = 9e-32
Identities = 99/325 (30%), Positives = 155/325 (47%), Gaps = 19/325 (5%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ + L + A H +N Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELE---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN P+F + T E L
Sbjct: 88 SRIDREELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPESRL 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVIRTNKALDRESV 650
+ + GA+DAD+G+N + Y+L D + + + S V+ K+LDRE
Sbjct: 148 LDSRFPLEGASDADIGVNALLSYKLSSSEFFFLDIQANDELSESLSLVL--GKSLDREET 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
A +L VA DGG P + TV + IK+ D+ND+ P F + EN+ GT + ++
Sbjct: 206 AEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLN 265
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA- 769
A D DEGPN+ + YS+ G D S++ + E+ T LDYE K YE+ + A
Sbjct: 266 ASDADEGPNSEIVYSL-GSDVSSTIQTKFTIDPISGEIRTKGKLDYEE-AKSYEIQVTAT 323
Query: 770 --ASPPLWNDVRVEILVTDVNDNAP 792
+P + ++ + + D+NDN P
Sbjct: 324 DKGTPSMSGHCKISLKLVDINDNTP 348
Score = 63.3 bits (147), Expect = 1e-08
Identities = 69/332 (20%), Positives = 147/332 (44%), Gaps = 22/332 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVPEEAKHGTFVGRI-AQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V ++++DIND+PP+F T E+ + +
Sbjct: 93 EELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPESRLLDSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMV---DLDYESPRKKY 763
A D D G NA++ Y + S F L+ + + +E +++V LD E +
Sbjct: 153 PLEGASDADIGVNALLSYKL---SSSEFFFLDIQANDELSESLSLVLGKSLDREETAEVN 209
Query: 764 ELVIR--AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
L++ P L V++ I V DVNDN P ++ ++ A DA
Sbjct: 210 LLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDA 269
Query: 822 D--VTDKLQYRILSGNNANL---ILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNE 875
D ++ Y + S ++ + ++ +G + +L+ K ++V+ TD G
Sbjct: 270 DEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPS 329
Query: 876 IKAMMQLSVRLI-----TEEMLLNSITVRLND 902
+ ++S++L+ T E+ + S+++ +++
Sbjct: 330 MSGHCKISLKLVDINDNTPEVSITSLSLPISE 361
>AF152310-1|AAD43704.1| 948|Homo sapiens protocadherin alpha 2
protein.
Length = 948
Score = 243 bits (594), Expect = 8e-63
Identities = 181/614 (29%), Positives = 285/614 (46%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHVEVIVDRPLQVFHVEVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDS 204
P F T+ E + D+ + A+DAD+G N+ + Y + +Q + D
Sbjct: 131 PIFPMTVKTIRFPES-RLLDSRFPLE-GASDADIGVNALLSYKLSSSEFFFLDIQAN-DE 187
Query: 205 LSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
LS +SLV K+LD E+ L++ A DGG P + T Q+LI + DVNDN P F S++
Sbjct: 188 LSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ + EN G +V++ A DADEG N+E+ Y++ D + + TIDP SG + T G
Sbjct: 248 KVKLLENTANGTLVVKLNASDADEGPNSEIVYSL-GSDVSSTIQTKFTIDPISGEIRTKG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LD E Y++ VTATD G P S + ++E+ G
Sbjct: 307 KLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLG 366
Query: 383 TPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
T + +T +D D H + + + T +N L+ + LD + Y L V
Sbjct: 367 TVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S T V I + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485
Query: 500 INAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD GV
Sbjct: 486 ENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEEVELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATDADVG 611
P L +++ V+D NDN P + + TA LV G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL F + +G I T +ALD H L + D G P ++T
Sbjct: 603 YNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 217 bits (529), Expect = 6e-55
Identities = 163/549 (29%), Positives = 257/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F ++ E+ + A DAD GVNA L+Y ++ ++
Sbjct: 121 VEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFF- 179
Query: 305 VDLPITIDPRSGWVYTSGQ-LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + G+ LDRE A+ LL+ ATDGG P + T
Sbjct: 180 LDIQANDELSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNE 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI---TGGNTRGRFSITSQN 418
F Y+V+L E+ GT VV L A+DADE ++ + Y + + +F+I +
Sbjct: 240 PTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPIS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G I LD+++ + Y + V+ATD G S + + + D N+ P +
Sbjct: 300 GE--IRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ E+A +GT + +++ +D D G N +T SL+ + + V+ + ++ +
Sbjct: 358 PISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL TT V I V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E V
Sbjct: 471 GCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ G + S + R G E+ T LD +SPR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQLG--TGSARIPFRVGLYTGEISTTRALDEADSPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 192 bits (468), Expect = 2e-47
Identities = 119/377 (31%), Positives = 194/377 (51%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQI--NITDANNYAPVFENAPYTASVFE 480
+ + + LD ++ L + ATD G T VQI + D N+ P F + Y + E
Sbjct: 194 LVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ GT V+ ++A+D+D G N++I YSL S++S+ +F I+P +G I T LD
Sbjct: 254 NTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTI----QTKFTIDPISGEIRTKGKLD 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + VTA D G PS+S + + +VD+NDN P + I E+A +GT +
Sbjct: 310 YEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G NG + L P + ++ + ALDRESV+ ++L A
Sbjct: 370 ALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V I++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENA 488
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWND 777
+V YS ++ + S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 489 LVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSN 548
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 549 VTLQVFVLDENDNAPAL 565
Score = 188 bits (459), Expect = 2e-46
Identities = 144/449 (32%), Positives = 216/449 (48%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSS-EIS 513
V++ + D N+ P+F T E + + + A+D+D+G+NA ++Y LSS E
Sbjct: 119 VEVEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ +D+ ++ ++ K LDRE + L + A DGG P L+ T + I V+D
Sbjct: 179 FLDIQANDEL----SESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
VNDNEP F Q +Y ++E+ GT V ++ A+DAD G N I Y L D + F
Sbjct: 235 VNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFT 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
IDP SG IRT LD E +++++ A D GTP S + +K+ DIND+ P
Sbjct: 295 IDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ ISEN+ +GT I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPISENASLGTVIALITVSDRDSGTNGHVTCSLT---PHVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW V I V DVNDNAP + ++
Sbjct: 411 SALDRESV-SAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPK 861
P V A+DAD + + Y ++ G A + + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 173 bits (420), Expect = 1e-41
Identities = 143/489 (29%), Positives = 218/489 (44%), Gaps = 40/489 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ P F Y+ + E ++GT V+ L A+D D G N+E+ Y++ + T
Sbjct: 230 IKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSST- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+Q F ID SG + T+ LD E+ Y + V ATD+ +P +
Sbjct: 289 ---------------IQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTP---SM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S I + ++D NDN P+ S + ++ + E+ S+ VIA I +D D G N + +
Sbjct: 331 SGHCKISLKLVDINDNTPEVSITSLSLPISENASL--GTVIALITVSDRDSGTNGHVTCS 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS TT + I +
Sbjct: 389 L---TPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
DVNDNAP F + V EN P G I V A+DAD NA ++Y++ ++ +
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 M---PGQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G ++E P G V + A DAD L YE+ G R
Sbjct: 566 LAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ + LD R+ L V D G + TA V +++ ++ AP + +
Sbjct: 626 LYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQ-APKASSRAWV 684
Query: 476 ASVFEDAPI 484
+ +A +
Sbjct: 685 GAAGSEATL 693
Score = 140 bits (338), Expect = 9e-32
Identities = 99/325 (30%), Positives = 155/325 (47%), Gaps = 19/325 (5%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ + L + A H +N Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELE---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN P+F + T E L
Sbjct: 88 SRIDREELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPESRL 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVIRTNKALDRESV 650
+ + GA+DAD+G+N + Y+L D + + + S V+ K+LDRE
Sbjct: 148 LDSRFPLEGASDADIGVNALLSYKLSSSEFFFLDIQANDELSESLSLVL--GKSLDREET 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
A +L VA DGG P + TV + IK+ D+ND+ P F + EN+ GT + ++
Sbjct: 206 AEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLN 265
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA- 769
A D DEGPN+ + YS+ G D S++ + E+ T LDYE K YE+ + A
Sbjct: 266 ASDADEGPNSEIVYSL-GSDVSSTIQTKFTIDPISGEIRTKGKLDYEE-AKSYEIQVTAT 323
Query: 770 --ASPPLWNDVRVEILVTDVNDNAP 792
+P + ++ + + D+NDN P
Sbjct: 324 DKGTPSMSGHCKISLKLVDINDNTP 348
Score = 63.3 bits (147), Expect = 1e-08
Identities = 69/332 (20%), Positives = 147/332 (44%), Gaps = 22/332 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVPEEAKHGTFVGRI-AQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V ++++DIND+PP+F T E+ + +
Sbjct: 93 EELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPESRLLDSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMV---DLDYESPRKKY 763
A D D G NA++ Y + S F L+ + + +E +++V LD E +
Sbjct: 153 PLEGASDADIGVNALLSYKL---SSSEFFFLDIQANDELSESLSLVLGKSLDREETAEVN 209
Query: 764 ELVIR--AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
L++ P L V++ I V DVNDN P ++ ++ A DA
Sbjct: 210 LLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDA 269
Query: 822 D--VTDKLQYRILSGNNANL---ILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNE 875
D ++ Y + S ++ + ++ +G + +L+ K ++V+ TD G
Sbjct: 270 DEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPS 329
Query: 876 IKAMMQLSVRLI-----TEEMLLNSITVRLND 902
+ ++S++L+ T E+ + S+++ +++
Sbjct: 330 MSGHCKISLKLVDINDNTPEVSITSLSLPISE 361
>AC005609-12|AAC34324.1| 824|Homo sapiens KIAA0345-like 12 protein.
Length = 824
Score = 243 bits (594), Expect = 8e-63
Identities = 181/614 (29%), Positives = 285/614 (46%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHVEVIVDRPLQVFHVEVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDS 204
P F T+ E + D+ + A+DAD+G N+ + Y + +Q + D
Sbjct: 131 PIFPMTVKTIRFPES-RLLDSRFPLE-GASDADIGVNALLSYKLSSSEFFFLDIQAN-DE 187
Query: 205 LSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
LS +SLV K+LD E+ L++ A DGG P + T Q+LI + DVNDN P F S++
Sbjct: 188 LSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ + EN G +V++ A DADEG N+E+ Y++ D + + TIDP SG + T G
Sbjct: 248 KVKLLENTANGTLVVKLNASDADEGPNSEIVYSL-GSDVSSTIQTKFTIDPISGEIRTKG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LD E Y++ VTATD G P S + ++E+ G
Sbjct: 307 KLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLG 366
Query: 383 TPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
T + +T +D D H + + + T +N L+ + LD + Y L V
Sbjct: 367 TVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S T V I + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485
Query: 500 INAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD GV
Sbjct: 486 ENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEEVELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATDADVG 611
P L +++ V+D NDN P + + TA LV G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL F + +G I T +ALD H L + D G P ++T
Sbjct: 603 YNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 217 bits (529), Expect = 6e-55
Identities = 163/549 (29%), Positives = 257/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F ++ E+ + A DAD GVNA L+Y ++ ++
Sbjct: 121 VEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFF- 179
Query: 305 VDLPITIDPRSGWVYTSGQ-LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + G+ LDRE A+ LL+ ATDGG P + T
Sbjct: 180 LDIQANDELSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNE 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEI---TGGNTRGRFSITSQN 418
F Y+V+L E+ GT VV L A+DADE ++ + Y + + +F+I +
Sbjct: 240 PTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPIS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G I LD+++ + Y + V+ATD G S + + + D N+ P +
Sbjct: 300 GE--IRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ E+A +GT + +++ +D D G N +T SL+ + + V+ + ++ +
Sbjct: 358 PISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL TT V I V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E V
Sbjct: 471 GCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ G + S + R G E+ T LD +SPR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQLG--TGSARIPFRVGLYTGEISTTRALDEADSPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 192 bits (468), Expect = 2e-47
Identities = 119/377 (31%), Positives = 194/377 (51%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQI--NITDANNYAPVFENAPYTASVFE 480
+ + + LD ++ L + ATD G T VQI + D N+ P F + Y + E
Sbjct: 194 LVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ GT V+ ++A+D+D G N++I YSL S++S+ +F I+P +G I T LD
Sbjct: 254 NTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTI----QTKFTIDPISGEIRTKGKLD 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + VTA D G PS+S + + +VD+NDN P + I E+A +GT +
Sbjct: 310 YEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G NG + L P + ++ + ALDRESV+ ++L A
Sbjct: 370 ALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V I++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENA 488
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWND 777
+V YS ++ + S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 489 LVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSN 548
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 549 VTLQVFVLDENDNAPAL 565
Score = 188 bits (459), Expect = 2e-46
Identities = 144/449 (32%), Positives = 216/449 (48%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSS-EIS 513
V++ + D N+ P+F T E + + + A+D+D+G+NA ++Y LSS E
Sbjct: 119 VEVEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ +D+ ++ ++ K LDRE + L + A DGG P L+ T + I V+D
Sbjct: 179 FLDIQANDEL----SESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
VNDNEP F Q +Y ++E+ GT V ++ A+DAD G N I Y L D + F
Sbjct: 235 VNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFT 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
IDP SG IRT LD E +++++ A D GTP S + +K+ DIND+ P
Sbjct: 295 IDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ ISEN+ +GT I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPISENASLGTVIALITVSDRDSGTNGHVTCSLT---PHVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW V I V DVNDNAP + ++
Sbjct: 411 SALDRESV-SAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPK 861
P V A+DAD + + Y ++ G A + + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 173 bits (420), Expect = 1e-41
Identities = 143/489 (29%), Positives = 218/489 (44%), Gaps = 40/489 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND+ P F Y+ + E ++GT V+ L A+D D G N+E+ Y++ + T
Sbjct: 230 IKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSST- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+Q F ID SG + T+ LD E+ Y + V ATD+ +P +
Sbjct: 289 ---------------IQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTP---SM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S I + ++D NDN P+ S + ++ + E+ S+ VIA I +D D G N + +
Sbjct: 331 SGHCKISLKLVDINDNTPEVSITSLSLPISENASL--GTVIALITVSDRDSGTNGHVTCS 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS TT + I +
Sbjct: 389 L---TPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
DVNDNAP F + V EN P G I V A+DAD NA ++Y++ ++ +
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 M---PGQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G ++E P G V + A DAD L YE+ G R
Sbjct: 566 LAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ + LD R+ L V D G + TA V +++ ++ AP + +
Sbjct: 626 LYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQ-APKASSRAWV 684
Query: 476 ASVFEDAPI 484
+ +A +
Sbjct: 685 GAAGSEATL 693
Score = 140 bits (338), Expect = 9e-32
Identities = 99/325 (30%), Positives = 155/325 (47%), Gaps = 19/325 (5%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ + L + A H +N Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELE---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN P+F + T E L
Sbjct: 88 SRIDREELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPESRL 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVIRTNKALDRESV 650
+ + GA+DAD+G+N + Y+L D + + + S V+ K+LDRE
Sbjct: 148 LDSRFPLEGASDADIGVNALLSYKLSSSEFFFLDIQANDELSESLSLVL--GKSLDREET 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
A +L VA DGG P + TV + IK+ D+ND+ P F + EN+ GT + ++
Sbjct: 206 AEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLN 265
Query: 711 AHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA- 769
A D DEGPN+ + YS+ G D S++ + E+ T LDYE K YE+ + A
Sbjct: 266 ASDADEGPNSEIVYSL-GSDVSSTIQTKFTIDPISGEIRTKGKLDYEE-AKSYEIQVTAT 323
Query: 770 --ASPPLWNDVRVEILVTDVNDNAP 792
+P + ++ + + D+NDN P
Sbjct: 324 DKGTPSMSGHCKISLKLVDINDNTP 348
Score = 63.3 bits (147), Expect = 1e-08
Identities = 69/332 (20%), Positives = 147/332 (44%), Gaps = 22/332 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVPEEAKHGTFVGRI-AQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V ++++DIND+PP+F T E+ + +
Sbjct: 93 EELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPESRLLDSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMV---DLDYESPRKKY 763
A D D G NA++ Y + S F L+ + + +E +++V LD E +
Sbjct: 153 PLEGASDADIGVNALLSYKL---SSSEFFFLDIQANDELSESLSLVLGKSLDREETAEVN 209
Query: 764 ELVIR--AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDA 821
L++ P L V++ I V DVNDN P ++ ++ A DA
Sbjct: 210 LLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDA 269
Query: 822 D--VTDKLQYRILSGNNANL---ILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNE 875
D ++ Y + S ++ + ++ +G + +L+ K ++V+ TD G
Sbjct: 270 DEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPS 329
Query: 876 IKAMMQLSVRLI-----TEEMLLNSITVRLND 902
+ ++S++L+ T E+ + S+++ +++
Sbjct: 330 MSGHCKISLKLVDINDNTPEVSITSLSLPISE 361
>BC027907-1|AAH27907.1| 924|Homo sapiens protocadherin 20 protein.
Length = 924
Score = 242 bits (593), Expect = 1e-62
Identities = 186/669 (27%), Positives = 303/669 (45%), Gaps = 28/669 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
+ + I D NDN PQF +V V E+ V I A D DVG N Y ++ +
Sbjct: 168 VKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEH-PAVDPDVGINGVQTYRLLDYH 226
Query: 196 TQMQFSID-SLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
++ + +G+ + ++ LD E Y +I A+DGGSP + L I I D+
Sbjct: 227 GMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDI 286
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F S +V N +G I VQA D D G NA++TY+ + K + DL
Sbjct: 287 NDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDL-FH 345
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXX--XXXXXFMP 368
+D +G + ++ ++L + A G P TA ++
Sbjct: 346 LDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIA 405
Query: 369 GQYE--VELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVA 426
+ + V L E EP TP+ T D + +++ + G N L+
Sbjct: 406 NEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETT 465
Query: 427 QPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGT 486
+P+D++ ++ Y + V A +S G ++++ + D N+ AP+F ++ E+
Sbjct: 466 KPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNA 525
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
+ + ATD+D Q++Y L + + F ++ TG +T + LDRE
Sbjct: 526 FLTKLYATDADSEERGQVSYFLGPDAPS--------YFSLDSVTGILTVSTQLDREEKEK 577
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
Y TV A D G P V ++V+D NDN P F + ++ + E+ + + T
Sbjct: 578 YRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVT 637
Query: 607 DADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
DAD G NG + + + FVID G++R +LDRE +++ L A+DGG P
Sbjct: 638 DADAGRNGWVALSV---VNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 694
Query: 667 QSSTVIVHIKIEDINDSPP--VFESDCLTFYISENSPI-GTTIGEIRAHDPDEGPNAVVH 723
SST + I + DIND+PP +F +++ + S + G+ + E+ A D D G NAV+
Sbjct: 695 LSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIA 754
Query: 724 YSIKG--GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVE 781
YSI G G SF ++ + G+ E ++ DY R ++ PL + V V
Sbjct: 755 YSIIGRRGPRPESFRIDPKTGNITLE-EALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVN 813
Query: 782 ILVTDVNDN 790
+ V D N
Sbjct: 814 LFVNDTVSN 822
Score = 182 bits (443), Expect = 2e-44
Identities = 191/703 (27%), Positives = 302/703 (42%), Gaps = 66/703 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTV-LTLKATDQDIGKNAEVEYTI-ELVTA 67
+I + D ND++P F + Q V E A T + + A D D+G N Y + +
Sbjct: 169 KIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGM 228
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
TL+ E+ R+ L+ +LDRE +Y ++ A D SP
Sbjct: 229 FTLDVEENENGE---------------RTPYLIVMGALDRETQDQYVSIIIAEDGGSPP- 272
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L +AT+ + I D NDN P F++ V+V + +V IA ++A D D+G N+ I
Sbjct: 273 --LLGSATLTIGISDINDNCPLFTDSQINVTVYGNATV--GTPIAAVQAVDKDLGTNAQI 328
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQL 243
Y+ + ++ F +D +G + L + + S++L I A G P+
Sbjct: 329 TYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVS 388
Query: 244 LIN-IRDVNDNAPRFYTS------LFQESVSENVPIGYSIVR--VQAYDADEGVNAELTY 294
+I I + PR+ + +E N PI + +R Y + ++ E +
Sbjct: 389 IIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPF 448
Query: 295 TMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
++ N L T P +D E Q Y++ V A +
Sbjct: 449 RLSPYKPYNNEYLLETTKP----------MDYELQQFYEVAVVAWN--SEGFHVKRVIKV 496
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFS 413
F+ E+ + E+ P + L ATDAD + R G + FS
Sbjct: 497 QLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFS 556
Query: 414 ITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFEN 471
+ S G++TV+ LD +++ +Y TV A D G R A V + + D N+ +P F N
Sbjct: 557 LDSVT--GILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFIN 614
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
++ V E+ P + V+S TD+D G N + S V + FVI+ G
Sbjct: 615 KDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALS---------VVNQSDIFVIDTGKG 665
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP--VFKQ-QLYTA 588
+ LDRE S Y L V A DGG P+LS T + I ++D+NDN P +F Q +
Sbjct: 666 MLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYL 725
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYE-LDPKDREEGSFVIDPASGVIRTNKALDR 647
++ L G+ V++V A D D G+N I Y + + SF IDP +G I +AL +
Sbjct: 726 LVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQ 785
Query: 648 ESVATHDLKAVAIDGGTP-PQSSTVIVHIKIEDINDSPPVFES 689
H L D G P P STV+V++ + D + ES
Sbjct: 786 TDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIES 828
Score = 169 bits (410), Expect = 2e-40
Identities = 166/647 (25%), Positives = 271/647 (41%), Gaps = 37/647 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADEGVNAELTYTMTDKDYTG 303
I IRD+NDNAP+F S V EN P+ + + A D D G+N TY + D Y G
Sbjct: 170 IAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLD--YHG 227
Query: 304 NVDLPITIDP---RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXX 360
L + + R+ ++ G LDRETQ +Y ++ A DGG PP +AT
Sbjct: 228 MFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDIN 287
Query: 361 XXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITS-Q 417
F Q V + + GTP+ + A D D + ++ Y + + +
Sbjct: 288 DNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLD 347
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQIN--ITDANNYAPVFENAP 473
G+I + + + LT+ A G TA+V I I P +
Sbjct: 348 ENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANE 407
Query: 474 YTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
V+ E P+ T + + D + Y ++ + E N +
Sbjct: 408 IDGVVYLKELEPVNTPIAFFTIRDPEG------KYKVNCYLDGEGPFRLSPYKPYNNEY- 460
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
+ T K +D E Y + V A + +++ ++D NDN P+F Q L I
Sbjct: 461 LLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIE 518
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVA 651
E+ ++++ ATDAD G++ Y L P F +D +G++ + LDRE
Sbjct: 519 ENNSPNAFLTKLYATDADSEERGQVSYFLGPD--APSYFSLDSVTGILTVSTQLDREEKE 576
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
+ A+D G PP+ S V + + D ND+ P F + +F++ EN P IG I
Sbjct: 577 KYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISV 636
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS 771
D D G N V S+ + S+ F ++T +G +A++ +D + +S + +
Sbjct: 637 TDADAGRNGWVALSVV--NQSDIFVIDTGKGMLRAKV--SLDREQQSSYTLWVEAVDGGE 692
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN---YKDCFPVGPFGRVPAYDAD--VTDK 826
P L + ++ IL+ D+NDN P++ Q + P P V A D D +
Sbjct: 693 PALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAV 752
Query: 827 LQYRILS--GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ Y I+ G ++ TG++TL L L + V V+D
Sbjct: 753 IAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSD 799
Score = 89.8 bits (213), Expect = 1e-16
Identities = 78/266 (29%), Positives = 126/266 (47%), Gaps = 33/266 (12%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F + + V E + + TD D G+N V ++ +
Sbjct: 600 LTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSV-------V 652
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D +F ID G L + SLDRE+ + YT+ V+A D P L
Sbjct: 653 NQSD--------------IFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA---L 695
Query: 131 SSTATIHVNIIDDNDNYP--QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
SSTA I + ++D NDN P F + + + ++ +PV ++ A D D G N+ I
Sbjct: 696 SSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPV-TEVYAVDKDTGMNAVIA 754
Query: 189 YAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+IIG G F ID +G+++L + L +RL+++ D G P ++T +++N
Sbjct: 755 YSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHST-VMVN 813
Query: 247 IRDVNDNAPR--FYTSLFQESVSENV 270
+ VND + SL ++ N+
Sbjct: 814 L-FVNDTVSNESYIESLLRKEPEINI 838
Score = 78.2 bits (184), Expect = 4e-13
Identities = 62/226 (27%), Positives = 105/226 (46%), Gaps = 10/226 (4%)
Query: 671 VIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDEGPNAVVHYSIKGG 729
V V I I DIND+ P F ++ ++ EN+P+ T + E A DPD G N V Y +
Sbjct: 166 VKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDY 225
Query: 730 DDSNSFSLETRQGSDKAE-LVTMVDLDYESPRKKYELVIR--AASPPLWNDVRVEILVTD 786
+ +E + ++ L+ M LD E+ + ++I SPPL + I ++D
Sbjct: 226 HGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISD 285
Query: 787 VNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQY-----RILSGNNANLIL 841
+NDN P+ D QI Y + P V A D D+ Q + + + +L
Sbjct: 286 INDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFH 345
Query: 842 LNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLI 887
L+E TG + L ++ +V + + + + +G I A++ V +I
Sbjct: 346 LDENTGVIKLFSKIGGSVLESHKLTI-LANGPGCIPAVITALVSII 390
>AL592490-1|CAH73802.2| 924|Homo sapiens protocadherin 20 protein.
Length = 924
Score = 242 bits (593), Expect = 1e-62
Identities = 186/669 (27%), Positives = 303/669 (45%), Gaps = 28/669 (4%)
Query: 136 IHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN 195
+ + I D NDN PQF +V V E+ V I A D DVG N Y ++ +
Sbjct: 168 VKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEH-PAVDPDVGINGVQTYRLLDYH 226
Query: 196 TQMQFSID-SLSGD----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDV 250
++ + +G+ + ++ LD E Y +I A+DGGSP + L I I D+
Sbjct: 227 GMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDI 286
Query: 251 NDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPIT 310
NDN P F S +V N +G I VQA D D G NA++TY+ + K + DL
Sbjct: 287 NDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDL-FH 345
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXX--XXXXXFMP 368
+D +G + ++ ++L + A G P TA ++
Sbjct: 346 LDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIA 405
Query: 369 GQYE--VELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVA 426
+ + V L E EP TP+ T D + +++ + G N L+
Sbjct: 406 NEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETT 465
Query: 427 QPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGT 486
+P+D++ ++ Y + V A +S G ++++ + D N+ AP+F ++ E+
Sbjct: 466 KPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNA 525
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
+ + ATD+D Q++Y L + + F ++ TG +T + LDRE
Sbjct: 526 FLTKLYATDADSEERGQVSYFLGPDAPS--------YFSLDSVTGILTVSTQLDREEKEK 577
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
Y TV A D G P V ++V+D NDN P F + ++ + E+ + + T
Sbjct: 578 YRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVT 637
Query: 607 DADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
DAD G NG + + + FVID G++R +LDRE +++ L A+DGG P
Sbjct: 638 DADAGRNGWVALSV---VNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 694
Query: 667 QSSTVIVHIKIEDINDSPP--VFESDCLTFYISENSPI-GTTIGEIRAHDPDEGPNAVVH 723
SST + I + DIND+PP +F +++ + S + G+ + E+ A D D G NAV+
Sbjct: 695 LSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIA 754
Query: 724 YSIKG--GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAASPPLWNDVRVE 781
YSI G G SF ++ + G+ E ++ DY R ++ PL + V V
Sbjct: 755 YSIIGRRGPRPESFRIDPKTGNITLE-EALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVN 813
Query: 782 ILVTDVNDN 790
+ V D N
Sbjct: 814 LFVNDTVSN 822
Score = 182 bits (443), Expect = 2e-44
Identities = 191/703 (27%), Positives = 302/703 (42%), Gaps = 66/703 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTV-LTLKATDQDIGKNAEVEYTI-ELVTA 67
+I + D ND++P F + Q V E A T + + A D D+G N Y + +
Sbjct: 169 KIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGM 228
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
TL+ E+ R+ L+ +LDRE +Y ++ A D SP
Sbjct: 229 FTLDVEENENGE---------------RTPYLIVMGALDRETQDQYVSIIIAEDGGSPP- 272
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L +AT+ + I D NDN P F++ V+V + +V IA ++A D D+G N+ I
Sbjct: 273 --LLGSATLTIGISDINDNCPLFTDSQINVTVYGNATV--GTPIAAVQAVDKDLGTNAQI 328
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGS-PSRSNTTQL 243
Y+ + ++ F +D +G + L + + S++L I A G P+
Sbjct: 329 TYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVS 388
Query: 244 LIN-IRDVNDNAPRFYTS------LFQESVSENVPIGYSIVR--VQAYDADEGVNAELTY 294
+I I + PR+ + +E N PI + +R Y + ++ E +
Sbjct: 389 IIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPF 448
Query: 295 TMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
++ N L T P +D E Q Y++ V A +
Sbjct: 449 RLSPYKPYNNEYLLETTKP----------MDYELQQFYEVAVVAWN--SEGFHVKRVIKV 496
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYE-ITGGNTRGRFS 413
F+ E+ + E+ P + L ATDAD + R G + FS
Sbjct: 497 QLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFS 556
Query: 414 ITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFEN 471
+ S G++TV+ LD +++ +Y TV A D G R A V + + D N+ +P F N
Sbjct: 557 LDSVT--GILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFIN 614
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
++ V E+ P + V+S TD+D G N + S V + FVI+ G
Sbjct: 615 KDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALS---------VVNQSDIFVIDTGKG 665
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP--VFKQ-QLYTA 588
+ LDRE S Y L V A DGG P+LS T + I ++D+NDN P +F Q +
Sbjct: 666 MLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYL 725
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYE-LDPKDREEGSFVIDPASGVIRTNKALDR 647
++ L G+ V++V A D D G+N I Y + + SF IDP +G I +AL +
Sbjct: 726 LVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQ 785
Query: 648 ESVATHDLKAVAIDGGTP-PQSSTVIVHIKIEDINDSPPVFES 689
H L D G P P STV+V++ + D + ES
Sbjct: 786 TDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIES 828
Score = 169 bits (410), Expect = 2e-40
Identities = 166/647 (25%), Positives = 271/647 (41%), Gaps = 37/647 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSI-VRVQAYDADEGVNAELTYTMTDKDYTG 303
I IRD+NDNAP+F S V EN P+ + + A D D G+N TY + D Y G
Sbjct: 170 IAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLD--YHG 227
Query: 304 NVDLPITIDP---RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXX 360
L + + R+ ++ G LDRETQ +Y ++ A DGG PP +AT
Sbjct: 228 MFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDIN 287
Query: 361 XXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITS-Q 417
F Q V + + GTP+ + A D D + ++ Y + + +
Sbjct: 288 DNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLD 347
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQIN--ITDANNYAPVFENAP 473
G+I + + + LT+ A G TA+V I I P +
Sbjct: 348 ENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANE 407
Query: 474 YTASVF--EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
V+ E P+ T + + D + Y ++ + E N +
Sbjct: 408 IDGVVYLKELEPVNTPIAFFTIRDPEG------KYKVNCYLDGEGPFRLSPYKPYNNEY- 460
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
+ T K +D E Y + V A + +++ ++D NDN P+F Q L I
Sbjct: 461 LLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIE 518
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVA 651
E+ ++++ ATDAD G++ Y L P F +D +G++ + LDRE
Sbjct: 519 ENNSPNAFLTKLYATDADSEERGQVSYFLGPD--APSYFSLDSVTGILTVSTQLDREEKE 576
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
+ A+D G PP+ S V + + D ND+ P F + +F++ EN P IG I
Sbjct: 577 KYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISV 636
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS 771
D D G N V S+ + S+ F ++T +G +A++ +D + +S + +
Sbjct: 637 TDADAGRNGWVALSVV--NQSDIFVIDTGKGMLRAKV--SLDREQQSSYTLWVEAVDGGE 692
Query: 772 PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNN---YKDCFPVGPFGRVPAYDAD--VTDK 826
P L + ++ IL+ D+NDN P++ Q + P P V A D D +
Sbjct: 693 PALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAV 752
Query: 827 LQYRILS--GNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD 871
+ Y I+ G ++ TG++TL L L + V V+D
Sbjct: 753 IAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSD 799
Score = 89.8 bits (213), Expect = 1e-16
Identities = 78/266 (29%), Positives = 126/266 (47%), Gaps = 33/266 (12%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND+SP F + + V E + + TD D G+N V ++ +
Sbjct: 600 LTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSV-------V 652
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
N D +F ID G L + SLDRE+ + YT+ V+A D P L
Sbjct: 653 NQSD--------------IFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA---L 695
Query: 131 SSTATIHVNIIDDNDNYP--QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
SSTA I + ++D NDN P F + + + ++ +PV ++ A D D G N+ I
Sbjct: 696 SSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPV-TEVYAVDKDTGMNAVIA 754
Query: 189 YAIIG--GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+IIG G F ID +G+++L + L +RL+++ D G P ++T +++N
Sbjct: 755 YSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHST-VMVN 813
Query: 247 IRDVNDNAPR--FYTSLFQESVSENV 270
+ VND + SL ++ N+
Sbjct: 814 L-FVNDTVSNESYIESLLRKEPEINI 838
Score = 78.2 bits (184), Expect = 4e-13
Identities = 62/226 (27%), Positives = 105/226 (46%), Gaps = 10/226 (4%)
Query: 671 VIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIG-EIRAHDPDEGPNAVVHYSIKGG 729
V V I I DIND+ P F ++ ++ EN+P+ T + E A DPD G N V Y +
Sbjct: 166 VKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDY 225
Query: 730 DDSNSFSLETRQGSDKAE-LVTMVDLDYESPRKKYELVIR--AASPPLWNDVRVEILVTD 786
+ +E + ++ L+ M LD E+ + ++I SPPL + I ++D
Sbjct: 226 HGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISD 285
Query: 787 VNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDADVTDKLQY-----RILSGNNANLIL 841
+NDN P+ D QI Y + P V A D D+ Q + + + +L
Sbjct: 286 INDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFH 345
Query: 842 LNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVRLI 887
L+E TG + L ++ +V + + + + +G I A++ V +I
Sbjct: 346 LDENTGVIKLFSKIGGSVLESHKLTI-LANGPGCIPAVITALVSII 390
>BC069064-1|AAH69064.1| 824|Homo sapiens PCDHA3 protein protein.
Length = 824
Score = 241 bits (589), Expect = 3e-62
Identities = 176/618 (28%), Positives = 288/618 (46%), Gaps = 35/618 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVEVEVKDINDNA 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E S + A+DAD+G NS + Y++ ++ F++D
Sbjct: 131 PVFPMAVKNLFISE--SRQPGSRFSLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRN 185
Query: 208 D-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
D + L K L+ E + L+I A DGG P + TTQL I + DVNDNAP F +
Sbjct: 186 DEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERT 245
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
+++ + EN P G +V V A D DEGVN ++ Y+ + D + ++ +DP +G +
Sbjct: 246 IYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSF-NTDMSADILSKFHLDPVNGQISV 304
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
G +D E Y++ V ATD G+PP S T + + + ED P
Sbjct: 305 KGNIDFEESKSYEVQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSP 364
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRY 437
T + ++ +D D+ ++ ++T T F + S +N L+ + PLD + Y
Sbjct: 365 LSTVIALISV--SDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAY 421
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA+V + + D N+ AP F + YT V E+ P G + VSA D
Sbjct: 422 ELVVTARDGGSPSLWATAIVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARD 481
Query: 496 SDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
+D NA ++YSL + A++ + ++ ++G + + LD E + V+AR
Sbjct: 482 ADAQENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEPVFKQQ-------LYTANIMEDALVGTSVSQVGATD 607
D GVP L +++ V+D NDN P + + G V++V A D
Sbjct: 539 DAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVD 598
Query: 608 ADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
AD G N + YEL P F + +G I T +ALD H L + D G P
Sbjct: 599 ADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPS 658
Query: 667 QSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 659 LTATATVLVSLVESGQAP 676
Score = 229 bits (560), Expect = 1e-58
Identities = 168/549 (30%), Positives = 260/549 (47%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDNAP F ++ +SE+ G A DAD G N+ LTY++ +Y
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYF-T 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + +S + L+RE K+ LL+TA DGG P + T
Sbjct: 180 LDVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEIT---GGNTRGRFSITSQN 418
F Y+V L E+ P GT VVT+ ATD DE + + Y + +F + N
Sbjct: 240 PAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVN 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G+ I+V +DF++ + Y + V ATD G SD V + I D N+ P +
Sbjct: 300 GQ--ISVKGNIDFEESKSYEVQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V ED+P+ T + ++S +D D G+N Q+T SL+ + + V+ + ++ +
Sbjct: 358 PVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SPLDRESVSAYELVVTARDGGSPSLWATAIVSVEVADVNDNAPAFSQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ G + + R G E+ T LD ++PR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDEVDAPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 213 bits (520), Expect = 8e-54
Identities = 172/613 (28%), Positives = 274/613 (44%), Gaps = 52/613 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND++PVF M + E G+ A+D DIG N+ + Y+++
Sbjct: 118 HVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG--RSGALLTRASLDREKVARYTVLVKATDQASP 125
TL DV R D +S L+ + +L+RE ++ +L+ A D P
Sbjct: 178 FTL-----------------DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKP 220
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
L+ T + + ++D NDN P F Y V + E+ + ++ + ATD D G N
Sbjct: 221 ---ELTGTTQLKITVLDVNDNAPAFERTIYKVRLLEN--APNGTLVVTVNATDLDEGVNK 275
Query: 186 AIRYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
I Y+ + + +F +D ++G +S+ +D+E+ +SY + + A D G+P S+
Sbjct: 276 DIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEESKSYEVQVEATDKGNPPMSDHCT 335
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+L+ I D+NDN P V E+ P+ I + D D GVN ++T ++T
Sbjct: 336 VLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTP---- 391
Query: 303 GNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 392 -HVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATAIVSVEVADVND 450
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQ 417
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S
Sbjct: 451 NAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSV 510
Query: 418 NGR-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF---EN 471
+ G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 511 HAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRV 570
Query: 472 APYTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+V E P G V V A D+D G NA ++Y L + F +
Sbjct: 571 GGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYT 587
TG I+T + LD + L V +D G PSL+ T V +S+V+ Q
Sbjct: 626 LYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAG 685
Query: 588 ANIMEDALVGTSV 600
A E ALV +V
Sbjct: 686 ATGPEAALVDVNV 698
Score = 196 bits (477), Expect = 1e-48
Identities = 116/377 (30%), Positives = 199/377 (52%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + L+ + ++ L ++A D G T Q+ IT D N+ AP FE Y + E
Sbjct: 194 LVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP GT V+ V+ATD D G+N I YS ++++S + ++ +F ++P G I+ +D
Sbjct: 254 NAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILS----KFHLDPVNGQISVKGNID 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A D G P +SD V + +VD+NDN P Q + ++ED+ + T +
Sbjct: 310 FEESKSYEVQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G+NG++ L P + ++ + LDRESV+ ++L A
Sbjct: 370 ALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T IV +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATAIVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENA 488
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASPPLWND 777
+V YS ++ + S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 489 LVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSN 548
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 549 VTLQVFVLDENDNAPAL 565
Score = 126 bits (303), Expect = 2e-27
Identities = 99/328 (30%), Positives = 147/328 (44%), Gaps = 25/328 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVSEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN PVF + I E
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQ 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVIRTNKALDRESV 650
G+ S GA+DAD+G N + Y LD D + I V++ N L+RE
Sbjct: 148 PGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLGLVLKKN--LNREDT 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
H L AIDGG P + T + I + D+ND+ P FE + EN+P GT + +
Sbjct: 206 PKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVN 265
Query: 711 AHDPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI 767
A D DEG N + YS D + F L+ G ++ ++D+E K YE+ +
Sbjct: 266 ATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG----QISVKGNIDFEE-SKSYEVQV 320
Query: 768 RA---ASPPLWNDVRVEILVTDVNDNAP 792
A +PP+ + V + + D+NDN P
Sbjct: 321 EATDKGNPPMSDHCTVLLEIVDINDNVP 348
Score = 72.9 bits (171), Expect = 1e-11
Identities = 55/214 (25%), Positives = 103/214 (48%), Gaps = 11/214 (5%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V ++++DIND+ PVF +ISE+ G+
Sbjct: 93 EELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G N+++ YS+ D + F+L+ ++ ++ + LV +L+ E K Y
Sbjct: 153 SLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRNDEEIKSLGLVLKKNLNREDTPKHY 209
Query: 764 ELV--IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
L+ I P L +++I V DVNDNAP +
Sbjct: 210 LLITAIDGGKPELTGTTQLKITVLDVNDNAPAFE 243
>AF152481-1|AAD43742.1| 824|Homo sapiens protocadherin alpha 3
short form protein protein.
Length = 824
Score = 240 bits (588), Expect = 4e-62
Identities = 176/618 (28%), Positives = 287/618 (46%), Gaps = 35/618 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVEVEVKDINDNA 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E S + A+DAD+G NS + Y++ ++ F++D
Sbjct: 131 PVFPMAVKNLFISE--SRQPGSRFSLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRN 185
Query: 208 D-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
D + L K L+ E + L+I A DGG P + TTQL I + DVNDNAP F +
Sbjct: 186 DEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERT 245
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
+++ + EN P G +V V A D DEGVN ++ Y+ + D + ++ +DP +G +
Sbjct: 246 IYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSF-NTDMSADILSKFHLDPVNGQISV 304
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
G +D E Y++ V ATD G+PP S T + + + ED P
Sbjct: 305 KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSP 364
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRY 437
T + ++ +D D+ ++ ++T T F + S +N L+ + PLD + Y
Sbjct: 365 LSTVIALISV--SDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAY 421
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D
Sbjct: 422 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARD 481
Query: 496 SDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
+D NA ++YSL + A++ + ++ ++G + + LD E + V+AR
Sbjct: 482 ADAQENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEPVFKQQ-------LYTANIMEDALVGTSVSQVGATD 607
D GVP L +++ V+D NDN P + + G V++V A D
Sbjct: 539 DAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVD 598
Query: 608 ADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
AD G N + YEL P F + +G I T +ALD H L + D G P
Sbjct: 599 ADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPS 658
Query: 667 QSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 659 LTATATVLVSLVESGQAP 676
Score = 231 bits (564), Expect = 4e-59
Identities = 168/549 (30%), Positives = 260/549 (47%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDNAP F ++ +SE+ G A DAD G N+ LTY++ +Y
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYF-T 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + +S + L+RE K+ LL+TA DGG P + T
Sbjct: 180 LDVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEIT---GGNTRGRFSITSQN 418
F Y+V L E+ P GT VVT+ ATD DE + + Y + +F + N
Sbjct: 240 PAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVN 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G+ I+V +DF++ + Y + V ATD G SD V + I D N+ P +
Sbjct: 300 GQ--ISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V ED+P+ T + ++S +D D G+N Q+T SL+ + + V+ + ++ +
Sbjct: 358 PVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ G + + R G E+ T LD ++PR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDEVDAPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 214 bits (523), Expect = 3e-54
Identities = 172/613 (28%), Positives = 275/613 (44%), Gaps = 52/613 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND++PVF M + E G+ A+D DIG N+ + Y+++
Sbjct: 118 HVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG--RSGALLTRASLDREKVARYTVLVKATDQASP 125
TL DV R D +S L+ + +L+RE ++ +L+ A D P
Sbjct: 178 FTL-----------------DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKP 220
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
L+ T + + ++D NDN P F Y V + E+ + ++ + ATD D G N
Sbjct: 221 ---ELTGTTQLKITVLDVNDNAPAFERTIYKVRLLEN--APNGTLVVTVNATDLDEGVNK 275
Query: 186 AIRYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
I Y+ + + +F +D ++G +S+ +D+E+ +SY + + A D G+P S+
Sbjct: 276 DIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCT 335
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+L+ I D+NDN P V E+ P+ I + D D GVN ++T ++T
Sbjct: 336 VLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTP---- 391
Query: 303 GNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 392 -HVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQ 417
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S
Sbjct: 451 NAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSV 510
Query: 418 NGR-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF---EN 471
+ G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 511 HAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRV 570
Query: 472 APYTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+V E P G V V A D+D G NA ++Y L + F +
Sbjct: 571 GGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYT 587
TG I+T + LD + L V +D G PSL+ T V +S+V+ Q
Sbjct: 626 LYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAG 685
Query: 588 ANIMEDALVGTSV 600
A E ALV +V
Sbjct: 686 ATGPEAALVDVNV 698
Score = 194 bits (472), Expect = 5e-48
Identities = 115/377 (30%), Positives = 198/377 (52%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + L+ + ++ L ++A D G T Q+ IT D N+ AP FE Y + E
Sbjct: 194 LVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP GT V+ V+ATD D G+N I YS ++++S + ++ +F ++P G I+ +D
Sbjct: 254 NAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILS----KFHLDPVNGQISVKGNID 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A D G P +SD V + +VD+NDN P Q + ++ED+ + T +
Sbjct: 310 FEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G+NG++ L P + ++ + LDRESV+ ++L A
Sbjct: 370 ALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENA 488
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWND 777
+V YS ++ + S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 489 LVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSN 548
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 549 VTLQVFVLDENDNAPAL 565
Score = 182 bits (443), Expect = 2e-44
Identities = 140/449 (31%), Positives = 217/449 (48%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL-SSEIS 513
V++ + D N+ APVF A + E G+ + A+D+D+G N+ +TYSL S+E
Sbjct: 119 VEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +D++ ++ + K L+RE + L +TA DGG P L+ TT ++I+V+D
Sbjct: 179 TLDVKRNDEEI----KSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE--GSFV 631
VNDN P F++ +Y ++E+A GT V V ATD D G+N I Y + + F
Sbjct: 235 VNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP +G I +D E +++++ A D G PP S V ++I DIND+ P
Sbjct: 295 LDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E+SP+ T I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLT---PHVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW V + V DVNDNAP + ++
Sbjct: 411 SPLDRESV-SAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + + Y ++ G A + + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 126 bits (304), Expect = 1e-27
Identities = 99/328 (30%), Positives = 147/328 (44%), Gaps = 25/328 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVSEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN PVF + I E
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQ 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVIRTNKALDRESV 650
G+ S GA+DAD+G N + Y LD D + I V++ N L+RE
Sbjct: 148 PGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLGLVLKKN--LNREDT 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
H L AIDGG P + T + I + D+ND+ P FE + EN+P GT + +
Sbjct: 206 PKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVN 265
Query: 711 AHDPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI 767
A D DEG N + YS D + F L+ G ++ ++D+E K YE+ +
Sbjct: 266 ATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG----QISVKGNIDFEE-SKSYEIQV 320
Query: 768 RA---ASPPLWNDVRVEILVTDVNDNAP 792
A +PP+ + V + + D+NDN P
Sbjct: 321 EATDKGNPPMSDHCTVLLEIVDINDNVP 348
Score = 72.9 bits (171), Expect = 1e-11
Identities = 55/214 (25%), Positives = 103/214 (48%), Gaps = 11/214 (5%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V ++++DIND+ PVF +ISE+ G+
Sbjct: 93 EELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G N+++ YS+ D + F+L+ ++ ++ + LV +L+ E K Y
Sbjct: 153 SLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRNDEEIKSLGLVLKKNLNREDTPKHY 209
Query: 764 ELV--IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
L+ I P L +++I V DVNDNAP +
Sbjct: 210 LLITAIDGGKPELTGTTQLKITVLDVNDNAPAFE 243
>AF152311-1|AAD43705.1| 950|Homo sapiens protocadherin alpha 3
protein.
Length = 950
Score = 240 bits (588), Expect = 4e-62
Identities = 176/618 (28%), Positives = 287/618 (46%), Gaps = 35/618 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVEVEVKDINDNA 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E S + A+DAD+G NS + Y++ ++ F++D
Sbjct: 131 PVFPMAVKNLFISE--SRQPGSRFSLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRN 185
Query: 208 D-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
D + L K L+ E + L+I A DGG P + TTQL I + DVNDNAP F +
Sbjct: 186 DEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERT 245
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
+++ + EN P G +V V A D DEGVN ++ Y+ + D + ++ +DP +G +
Sbjct: 246 IYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSF-NTDMSADILSKFHLDPVNGQISV 304
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
G +D E Y++ V ATD G+PP S T + + + ED P
Sbjct: 305 KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSP 364
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRY 437
T + ++ +D D+ ++ ++T T F + S +N L+ + PLD + Y
Sbjct: 365 LSTVIALISV--SDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAY 421
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D
Sbjct: 422 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARD 481
Query: 496 SDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
+D NA ++YSL + A++ + ++ ++G + + LD E + V+AR
Sbjct: 482 ADAQENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEPVFKQQ-------LYTANIMEDALVGTSVSQVGATD 607
D GVP L +++ V+D NDN P + + G V++V A D
Sbjct: 539 DAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVD 598
Query: 608 ADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
AD G N + YEL P F + +G I T +ALD H L + D G P
Sbjct: 599 ADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPS 658
Query: 667 QSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 659 LTATATVLVSLVESGQAP 676
Score = 231 bits (564), Expect = 4e-59
Identities = 168/549 (30%), Positives = 260/549 (47%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDNAP F ++ +SE+ G A DAD G N+ LTY++ +Y
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYF-T 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + +S + L+RE K+ LL+TA DGG P + T
Sbjct: 180 LDVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEIT---GGNTRGRFSITSQN 418
F Y+V L E+ P GT VVT+ ATD DE + + Y + +F + N
Sbjct: 240 PAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVN 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G+ I+V +DF++ + Y + V ATD G SD V + I D N+ P +
Sbjct: 300 GQ--ISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V ED+P+ T + ++S +D D G+N Q+T SL+ + + V+ + ++ +
Sbjct: 358 PVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ G + + R G E+ T LD ++PR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDEVDAPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 214 bits (523), Expect = 3e-54
Identities = 172/613 (28%), Positives = 275/613 (44%), Gaps = 52/613 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND++PVF M + E G+ A+D DIG N+ + Y+++
Sbjct: 118 HVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG--RSGALLTRASLDREKVARYTVLVKATDQASP 125
TL DV R D +S L+ + +L+RE ++ +L+ A D P
Sbjct: 178 FTL-----------------DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKP 220
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
L+ T + + ++D NDN P F Y V + E+ + ++ + ATD D G N
Sbjct: 221 ---ELTGTTQLKITVLDVNDNAPAFERTIYKVRLLEN--APNGTLVVTVNATDLDEGVNK 275
Query: 186 AIRYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
I Y+ + + +F +D ++G +S+ +D+E+ +SY + + A D G+P S+
Sbjct: 276 DIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCT 335
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+L+ I D+NDN P V E+ P+ I + D D GVN ++T ++T
Sbjct: 336 VLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTP---- 391
Query: 303 GNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 392 -HVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQ 417
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S
Sbjct: 451 NAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSV 510
Query: 418 NGR-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF---EN 471
+ G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 511 HAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRV 570
Query: 472 APYTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+V E P G V V A D+D G NA ++Y L + F +
Sbjct: 571 GGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYT 587
TG I+T + LD + L V +D G PSL+ T V +S+V+ Q
Sbjct: 626 LYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAG 685
Query: 588 ANIMEDALVGTSV 600
A E ALV +V
Sbjct: 686 ATGPEAALVDVNV 698
Score = 194 bits (472), Expect = 5e-48
Identities = 115/377 (30%), Positives = 198/377 (52%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + L+ + ++ L ++A D G T Q+ IT D N+ AP FE Y + E
Sbjct: 194 LVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP GT V+ V+ATD D G+N I YS ++++S + ++ +F ++P G I+ +D
Sbjct: 254 NAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILS----KFHLDPVNGQISVKGNID 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A D G P +SD V + +VD+NDN P Q + ++ED+ + T +
Sbjct: 310 FEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G+NG++ L P + ++ + LDRESV+ ++L A
Sbjct: 370 ALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENA 488
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWND 777
+V YS ++ + S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 489 LVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSN 548
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 549 VTLQVFVLDENDNAPAL 565
Score = 182 bits (443), Expect = 2e-44
Identities = 140/449 (31%), Positives = 217/449 (48%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL-SSEIS 513
V++ + D N+ APVF A + E G+ + A+D+D+G N+ +TYSL S+E
Sbjct: 119 VEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +D++ ++ + K L+RE + L +TA DGG P L+ TT ++I+V+D
Sbjct: 179 TLDVKRNDEEI----KSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE--GSFV 631
VNDN P F++ +Y ++E+A GT V V ATD D G+N I Y + + F
Sbjct: 235 VNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP +G I +D E +++++ A D G PP S V ++I DIND+ P
Sbjct: 295 LDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E+SP+ T I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLT---PHVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW V + V DVNDNAP + ++
Sbjct: 411 SPLDRESV-SAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + + Y ++ G A + + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 126 bits (304), Expect = 1e-27
Identities = 99/328 (30%), Positives = 147/328 (44%), Gaps = 25/328 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVSEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN PVF + I E
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQ 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVIRTNKALDRESV 650
G+ S GA+DAD+G N + Y LD D + I V++ N L+RE
Sbjct: 148 PGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLGLVLKKN--LNREDT 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
H L AIDGG P + T + I + D+ND+ P FE + EN+P GT + +
Sbjct: 206 PKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVN 265
Query: 711 AHDPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI 767
A D DEG N + YS D + F L+ G ++ ++D+E K YE+ +
Sbjct: 266 ATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG----QISVKGNIDFEE-SKSYEIQV 320
Query: 768 RA---ASPPLWNDVRVEILVTDVNDNAP 792
A +PP+ + V + + D+NDN P
Sbjct: 321 EATDKGNPPMSDHCTVLLEIVDINDNVP 348
Score = 72.9 bits (171), Expect = 1e-11
Identities = 55/214 (25%), Positives = 103/214 (48%), Gaps = 11/214 (5%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V ++++DIND+ PVF +ISE+ G+
Sbjct: 93 EELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G N+++ YS+ D + F+L+ ++ ++ + LV +L+ E K Y
Sbjct: 153 SLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRNDEEIKSLGLVLKKNLNREDTPKHY 209
Query: 764 ELV--IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
L+ I P L +++I V DVNDNAP +
Sbjct: 210 LLITAIDGGKPELTGTTQLKITVLDVNDNAPAFE 243
>AC005609-11|AAC34323.1| 824|Homo sapiens KIAA0345-like 11 protein.
Length = 824
Score = 240 bits (588), Expect = 4e-62
Identities = 176/618 (28%), Positives = 287/618 (46%), Gaps = 35/618 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVEVEVKDINDNA 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E S + A+DAD+G NS + Y++ ++ F++D
Sbjct: 131 PVFPMAVKNLFISE--SRQPGSRFSLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRN 185
Query: 208 D-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
D + L K L+ E + L+I A DGG P + TTQL I + DVNDNAP F +
Sbjct: 186 DEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERT 245
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
+++ + EN P G +V V A D DEGVN ++ Y+ + D + ++ +DP +G +
Sbjct: 246 IYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSF-NTDMSADILSKFHLDPVNGQISV 304
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
G +D E Y++ V ATD G+PP S T + + + ED P
Sbjct: 305 KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSP 364
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRY 437
T + ++ +D D+ ++ ++T T F + S +N L+ + PLD + Y
Sbjct: 365 LSTVIALISV--SDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAY 421
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D
Sbjct: 422 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARD 481
Query: 496 SDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
+D NA ++YSL + A++ + ++ ++G + + LD E + V+AR
Sbjct: 482 ADAQENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEPVFKQQ-------LYTANIMEDALVGTSVSQVGATD 607
D GVP L +++ V+D NDN P + + G V++V A D
Sbjct: 539 DAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVD 598
Query: 608 ADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
AD G N + YEL P F + +G I T +ALD H L + D G P
Sbjct: 599 ADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPS 658
Query: 667 QSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 659 LTATATVLVSLVESGQAP 676
Score = 231 bits (564), Expect = 4e-59
Identities = 168/549 (30%), Positives = 260/549 (47%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDNAP F ++ +SE+ G A DAD G N+ LTY++ +Y
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYF-T 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + +S + L+RE K+ LL+TA DGG P + T
Sbjct: 180 LDVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEIT---GGNTRGRFSITSQN 418
F Y+V L E+ P GT VVT+ ATD DE + + Y + +F + N
Sbjct: 240 PAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVN 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G+ I+V +DF++ + Y + V ATD G SD V + I D N+ P +
Sbjct: 300 GQ--ISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V ED+P+ T + ++S +D D G+N Q+T SL+ + + V+ + ++ +
Sbjct: 358 PVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ G + + R G E+ T LD ++PR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDEVDAPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 214 bits (523), Expect = 3e-54
Identities = 172/613 (28%), Positives = 275/613 (44%), Gaps = 52/613 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND++PVF M + E G+ A+D DIG N+ + Y+++
Sbjct: 118 HVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG--RSGALLTRASLDREKVARYTVLVKATDQASP 125
TL DV R D +S L+ + +L+RE ++ +L+ A D P
Sbjct: 178 FTL-----------------DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKP 220
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
L+ T + + ++D NDN P F Y V + E+ + ++ + ATD D G N
Sbjct: 221 ---ELTGTTQLKITVLDVNDNAPAFERTIYKVRLLEN--APNGTLVVTVNATDLDEGVNK 275
Query: 186 AIRYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
I Y+ + + +F +D ++G +S+ +D+E+ +SY + + A D G+P S+
Sbjct: 276 DIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCT 335
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+L+ I D+NDN P V E+ P+ I + D D GVN ++T ++T
Sbjct: 336 VLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTP---- 391
Query: 303 GNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 392 -HVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQ 417
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S
Sbjct: 451 NAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSV 510
Query: 418 NGR-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF---EN 471
+ G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 511 HAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRV 570
Query: 472 APYTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+V E P G V V A D+D G NA ++Y L + F +
Sbjct: 571 GGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYT 587
TG I+T + LD + L V +D G PSL+ T V +S+V+ Q
Sbjct: 626 LYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAG 685
Query: 588 ANIMEDALVGTSV 600
A E ALV +V
Sbjct: 686 ATGPEAALVDVNV 698
Score = 194 bits (472), Expect = 5e-48
Identities = 115/377 (30%), Positives = 198/377 (52%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + L+ + ++ L ++A D G T Q+ IT D N+ AP FE Y + E
Sbjct: 194 LVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP GT V+ V+ATD D G+N I YS ++++S + ++ +F ++P G I+ +D
Sbjct: 254 NAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILS----KFHLDPVNGQISVKGNID 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A D G P +SD V + +VD+NDN P Q + ++ED+ + T +
Sbjct: 310 FEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G+NG++ L P + ++ + LDRESV+ ++L A
Sbjct: 370 ALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENA 488
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWND 777
+V YS ++ + S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 489 LVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSN 548
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 549 VTLQVFVLDENDNAPAL 565
Score = 182 bits (443), Expect = 2e-44
Identities = 140/449 (31%), Positives = 217/449 (48%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL-SSEIS 513
V++ + D N+ APVF A + E G+ + A+D+D+G N+ +TYSL S+E
Sbjct: 119 VEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +D++ ++ + K L+RE + L +TA DGG P L+ TT ++I+V+D
Sbjct: 179 TLDVKRNDEEI----KSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE--GSFV 631
VNDN P F++ +Y ++E+A GT V V ATD D G+N I Y + + F
Sbjct: 235 VNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP +G I +D E +++++ A D G PP S V ++I DIND+ P
Sbjct: 295 LDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E+SP+ T I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLT---PHVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW V + V DVNDNAP + ++
Sbjct: 411 SPLDRESV-SAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + + Y ++ G A + + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 126 bits (304), Expect = 1e-27
Identities = 99/328 (30%), Positives = 147/328 (44%), Gaps = 25/328 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVSEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN PVF + I E
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQ 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVIRTNKALDRESV 650
G+ S GA+DAD+G N + Y LD D + I V++ N L+RE
Sbjct: 148 PGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLGLVLKKN--LNREDT 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
H L AIDGG P + T + I + D+ND+ P FE + EN+P GT + +
Sbjct: 206 PKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVN 265
Query: 711 AHDPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI 767
A D DEG N + YS D + F L+ G ++ ++D+E K YE+ +
Sbjct: 266 ATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG----QISVKGNIDFEE-SKSYEIQV 320
Query: 768 RA---ASPPLWNDVRVEILVTDVNDNAP 792
A +PP+ + V + + D+NDN P
Sbjct: 321 EATDKGNPPMSDHCTVLLEIVDINDNVP 348
Score = 72.9 bits (171), Expect = 1e-11
Identities = 55/214 (25%), Positives = 103/214 (48%), Gaps = 11/214 (5%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V ++++DIND+ PVF +ISE+ G+
Sbjct: 93 EELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G N+++ YS+ D + F+L+ ++ ++ + LV +L+ E K Y
Sbjct: 153 SLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRNDEEIKSLGLVLKKNLNREDTPKHY 209
Query: 764 ELV--IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
L+ I P L +++I V DVNDNAP +
Sbjct: 210 LLITAIDGGKPELTGTTQLKITVLDVNDNAPAFE 243
>BC129807-1|AAI29808.1| 824|Homo sapiens protocadherin alpha 3
protein.
Length = 824
Score = 239 bits (585), Expect = 1e-61
Identities = 176/618 (28%), Positives = 286/618 (46%), Gaps = 35/618 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVEVEVKDINDNA 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E S + A+DAD+G NS + Y++ ++ F++D
Sbjct: 131 PVFPMAVKNLFISE--SRQPGSRFSLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRN 185
Query: 208 D-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
D + L K L+ E + L+I A DGG P + TTQL I + DVNDNAP F +
Sbjct: 186 DEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERT 245
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
+++ + EN P G +V V A D DEGVN ++ Y+ + D + + +DP +G +
Sbjct: 246 IYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSF-NTDMSADTLSKFHLDPVNGQISV 304
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
G +D E Y++ V ATD G+PP S T + + + ED P
Sbjct: 305 KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSP 364
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRY 437
T + ++ +D D+ ++ ++T T F + S +N L+ + PLD + Y
Sbjct: 365 LSTVIALISV--SDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAY 421
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D
Sbjct: 422 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARD 481
Query: 496 SDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
+D NA ++YSL + A++ + ++ ++G + + LD E + V+AR
Sbjct: 482 ADAQENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSAR 538
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEPVFKQQ-------LYTANIMEDALVGTSVSQVGATD 607
D GVP L +++ V+D NDN P + + G V++V A D
Sbjct: 539 DAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVD 598
Query: 608 ADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
AD G N + YEL P F + +G I T +ALD H L + D G P
Sbjct: 599 ADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPS 658
Query: 667 QSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 659 LTATATVLVSLVESGQAP 676
Score = 233 bits (570), Expect = 7e-60
Identities = 169/549 (30%), Positives = 261/549 (47%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDNAP F ++ +SE+ G A DAD G N+ LTY++ +Y
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYF-T 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + +S + L+RE K+ LL+TA DGG P + T
Sbjct: 180 LDVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEIT---GGNTRGRFSITSQN 418
F Y+V L E+ P GT VVT+ ATD DE + + Y +T +F + N
Sbjct: 240 PAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADTLSKFHLDPVN 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G+ I+V +DF++ + Y + V ATD G SD V + I D N+ P +
Sbjct: 300 GQ--ISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V ED+P+ T + ++S +D D G+N Q+T SL+ + + V+ + ++ +
Sbjct: 358 PVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ G + + R G E+ T LD ++PR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDEVDAPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 217 bits (529), Expect = 6e-55
Identities = 173/613 (28%), Positives = 276/613 (45%), Gaps = 52/613 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND++PVF M + E G+ A+D DIG N+ + Y+++
Sbjct: 118 HVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG--RSGALLTRASLDREKVARYTVLVKATDQASP 125
TL DV R D +S L+ + +L+RE ++ +L+ A D P
Sbjct: 178 FTL-----------------DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKP 220
Query: 126 VSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS 185
L+ T + + ++D NDN P F Y V + E+ + ++ + ATD D G N
Sbjct: 221 ---ELTGTTQLKITVLDVNDNAPAFERTIYKVRLLEN--APNGTLVVTVNATDLDEGVNK 275
Query: 186 AIRYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
I Y+ + +T +F +D ++G +S+ +D+E+ +SY + + A D G+P S+
Sbjct: 276 DIAYSFNTDMSADTLSKFHLDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCT 335
Query: 243 LLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYT 302
+L+ I D+NDN P V E+ P+ I + D D GVN ++T ++T
Sbjct: 336 VLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTP---- 391
Query: 303 GNVDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 392 -HVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQ 417
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S
Sbjct: 451 NAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSV 510
Query: 418 NGR-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF---EN 471
+ G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 511 HAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRV 570
Query: 472 APYTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+V E P G V V A D+D G NA ++Y L + F +
Sbjct: 571 GGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYT 587
TG I+T + LD + L V +D G PSL+ T V +S+V+ Q
Sbjct: 626 LYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAG 685
Query: 588 ANIMEDALVGTSV 600
A E ALV +V
Sbjct: 686 ATGPEAALVDVNV 698
Score = 194 bits (473), Expect = 4e-48
Identities = 115/377 (30%), Positives = 198/377 (52%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + L+ + ++ L ++A D G T Q+ IT D N+ AP FE Y + E
Sbjct: 194 LVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP GT V+ V+ATD D G+N I YS ++++S + ++ +F ++P G I+ +D
Sbjct: 254 NAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADTLS----KFHLDPVNGQISVKGNID 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A D G P +SD V + +VD+NDN P Q + ++ED+ + T +
Sbjct: 310 FEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G+NG++ L P + ++ + LDRESV+ ++L A
Sbjct: 370 ALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSPLDRESVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENA 488
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWND 777
+V YS ++ + S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 489 LVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSN 548
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 549 VTLQVFVLDENDNAPAL 565
Score = 182 bits (443), Expect = 2e-44
Identities = 140/449 (31%), Positives = 217/449 (48%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL-SSEIS 513
V++ + D N+ APVF A + E G+ + A+D+D+G N+ +TYSL S+E
Sbjct: 119 VEVEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +D++ ++ + K L+RE + L +TA DGG P L+ TT ++I+V+D
Sbjct: 179 TLDVKRNDEEI----KSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE--GSFV 631
VNDN P F++ +Y ++E+A GT V V ATD D G+N I Y + + F
Sbjct: 235 VNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADTLSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP +G I +D E +++++ A D G PP S V ++I DIND+ P
Sbjct: 295 LDPVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E+SP+ T I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLT---PHVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW V + V DVNDNAP + ++
Sbjct: 411 SPLDRESV-SAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + + Y ++ G A + + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 127 bits (306), Expect = 7e-28
Identities = 99/328 (30%), Positives = 147/328 (44%), Gaps = 25/328 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVSEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN PVF + I E
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQ 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVIRTNKALDRESV 650
G+ S GA+DAD+G N + Y LD D + I V++ N L+RE
Sbjct: 148 PGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLGLVLKKN--LNREDT 205
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIR 710
H L AIDGG P + T + I + D+ND+ P FE + EN+P GT + +
Sbjct: 206 PKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVN 265
Query: 711 AHDPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI 767
A D DEG N + YS D + F L+ G ++ ++D+E K YE+ +
Sbjct: 266 ATDLDEGVNKDIAYSFNTDMSADTLSKFHLDPVNG----QISVKGNIDFEE-SKSYEIQV 320
Query: 768 RA---ASPPLWNDVRVEILVTDVNDNAP 792
A +PP+ + V + + D+NDN P
Sbjct: 321 EATDKGNPPMSDHCTVLLEIVDINDNVP 348
Score = 72.9 bits (171), Expect = 1e-11
Identities = 55/214 (25%), Positives = 103/214 (48%), Gaps = 11/214 (5%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V ++++DIND+ PVF +ISE+ G+
Sbjct: 93 EELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQPGSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G N+++ YS+ D + F+L+ ++ ++ + LV +L+ E K Y
Sbjct: 153 SLEGASDADIGTNSLLTYSL---DSTEYFTLDVKRNDEEIKSLGLVLKKNLNREDTPKHY 209
Query: 764 ELV--IRAASPPLWNDVRVEILVTDVNDNAPVMK 795
L+ I P L +++I V DVNDNAP +
Sbjct: 210 LLITAIDGGKPELTGTTQLKITVLDVNDNAPAFE 243
>AF152513-1|AAD43773.1| 818|Homo sapiens protocadherin gamma A6
short form protein protein.
Length = 818
Score = 239 bits (585), Expect = 1e-61
Identities = 189/609 (31%), Positives = 292/609 (47%), Gaps = 34/609 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ R+G+L+T +DRE++ + + V D+L+ + V I+D NDN P
Sbjct: 74 LFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNIL-VEDKLN-LYPVEVEIVDINDNTP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
+F ++ V + E+ + + + ++ D DVG NS + + GN+ + S +
Sbjct: 132 RFLKEELEVKILENAAPSSRFPLMEVY--DPDVGMNSLQGFKL-SGNSHFSVDVQSEAHG 188
Query: 208 ----DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
++ L TLD E YRLV+ A DGG P RS+ Q+L+ + DVNDN P F +++
Sbjct: 189 PKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYR 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
SV EN+P+G ++ V A D DEGV+ E+TY+ T + ++ +G + TS
Sbjct: 249 VSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFV--KITEKISQIFCLNVLTGEISTSAN 306
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E + Y+L V A DG A G + AE PPGT
Sbjct: 307 LDYEDSSFYELGVEARDGPGLRDRAKVLITILDVNDNVPEVVVTSGSRTI--AESAPPGT 364
Query: 384 PVVTLTATDADEDNRLHYEITGGNTRG-RFSITSQNGR--GLITVAQPLDFKQERRYVLT 440
+ D D+ L+ +T R F + G L+T A LD ++ Y +T
Sbjct: 365 VIALFQV--FDRDSGLNGLVTCSIPRSLPFELEKSVGNYYRLVTNA-ALDREEVFLYNIT 421
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+ATD G S ++ +N+ D N+ P F ++ Y+ V E+ P G ++ V+A D DV
Sbjct: 422 VTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDV 481
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NAQ++YSL+ + A IN TG + + D E + L VTA D G
Sbjct: 482 DQNAQVSYSLAEDTLQGAPL--SSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGD 539
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADVG 611
P LS + + V+D NDN P + L T A G V++V A D D G
Sbjct: 540 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG 599
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSST 670
N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+T
Sbjct: 600 QNAWLSYRL-LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSAT 657
Query: 671 VIVHIKIED 679
V + + + D
Sbjct: 658 VTLTVAVAD 666
Score = 206 bits (504), Expect = 7e-52
Identities = 176/599 (29%), Positives = 272/599 (45%), Gaps = 36/599 (6%)
Query: 310 TIDPRSGWVYTSGQLDRETQ-AKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
+++PR+G + T+G++DRE A+ + + + + F+
Sbjct: 76 SLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFLK 135
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQ-NGRGL--IT 424
+ EV++ E+ P + + D D N L GN+ + S+ +G +
Sbjct: 136 EELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPELV 195
Query: 425 VAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+ LD + E Y L ++A D G RS A + + + D N+ P+F Y SV E+
Sbjct: 196 LEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENL 255
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
P+GT VL V+ATD D G++ ++TYS E ++ Q F +N TG I+T+ LD E
Sbjct: 256 PVGTPVLAVTATDQDEGVHGEVTYSFVK--ITEKIS---QIFCLNVLTGEISTSANLDYE 310
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
S Y L V ARDG P L D V I+++DVNDN P + I E A GT ++
Sbjct: 311 DSSFYELGVEARDG--PGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIAL 368
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV---IRTNKALDRESVATHDLKAVA 659
D D GLNG + + P+ F ++ + G + TN ALDRE V +++ A
Sbjct: 369 FQVFDRDSGLNGLVTCSI-PRSLP---FELEKSVGNYYRLVTNAALDREEVFLYNITVTA 424
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D GTPP S+ I+ + + D ND+PP F + Y+ EN+P G +I + A DPD N
Sbjct: 425 TDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQN 484
Query: 720 AVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWN 776
A V YS+ S SD L + DYE R V + S PPL +
Sbjct: 485 AQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGDPPLSS 544
Query: 777 DVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------DADVTDK 826
+V + + V D NDNAP + + + + + P P Y D+
Sbjct: 545 NVSLSLFVLDQNDNAPEIL-YPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAW 603
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSV 884
L YR+L + L + TG + + L ++ V+V D G + A + L+V
Sbjct: 604 LSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTV 662
Score = 195 bits (475), Expect = 2e-48
Identities = 166/584 (28%), Positives = 264/584 (45%), Gaps = 57/584 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND++P F ++ E + E A+ + ++ D D+G N+ + + + +
Sbjct: 120 EVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFS 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
++ + + L+ +LDRE A Y +++ A D PV
Sbjct: 180 VDVQSEAH---------------GPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVR-- 222
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SS A I V ++D NDN P F++ Y VSV E++ V PV+A + ATD D G + + Y
Sbjct: 223 -SSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPV-GTPVLA-VTATDQDEGVHGEVTY 279
Query: 190 AIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + ++ F ++ L+G++S LDYE Y L + A+DG P + ++LI I
Sbjct: 280 SFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDG--PGLRDRAKVLITI 337
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
DVNDN P + +++E+ P G I Q +D D G+N +T ++ L
Sbjct: 338 LDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPR-------SL 390
Query: 308 PITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
P ++ G Y T+ LDRE Y + VTATD G PP S
Sbjct: 391 PFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPP 450
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDN--RLHYEITGGNTRGR--FSITSQNG- 419
F Y V + E+ P G + ++ A D D D ++ Y + +G S S N
Sbjct: 451 TFPHSSYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSD 510
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPYT 475
G++ + D++Q R L V+A+DSG S + + + D N+ AP ++ P
Sbjct: 511 TGILYALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTD 570
Query: 476 ASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
S E AP G V V A D D G NA ++Y L A F + T
Sbjct: 571 GSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK-------ASEPGLFSVGLHT 623
Query: 531 GAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
G + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 624 GEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 118 bits (285), Expect = 2e-25
Identities = 88/283 (31%), Positives = 134/283 (47%), Gaps = 22/283 (7%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP+ G++ T +DRE + + + + V + VE+ +VD+NDN P
Sbjct: 73 QLFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPR 132
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLN--------GRIHYELDPKDREEGSFVI 632
F ++ I+E+A + + D DVG+N G H+ +D + G
Sbjct: 133 FLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHG---- 188
Query: 633 DPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL 692
P + LDRE A + L A+DGG P +SS + + + D+ND+ P+F
Sbjct: 189 -PKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVY 247
Query: 693 TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYS-IKGGDD-SNSFSLETRQGSDKAELVT 750
+ EN P+GT + + A D DEG + V YS +K + S F L G E+ T
Sbjct: 248 RVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTG----EIST 303
Query: 751 MVDLDYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
+LDYE YEL + A P L + +V I + DVNDN P
Sbjct: 304 SANLDYED-SSFYELGVEARDGPGLRDRAKVLITILDVNDNVP 345
Score = 66.5 bits (155), Expect = 1e-09
Identities = 65/252 (25%), Positives = 109/252 (43%), Gaps = 11/252 (4%)
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKA-VAIDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F ++P +G + T +DRE + + V+ + + + V ++I DIND+ P F
Sbjct: 75 FSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFL 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAEL 748
+ L I EN+ + + +DPD G N++ + + G + G EL
Sbjct: 135 KEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPEL 194
Query: 749 VTMVDLDYESPRKKYELVIRA--ASPPLWNDV-RVEILVTDVNDNAPVMKDFQIIFNNYK 805
V LD E Y LV+ A P+ + V ++ + V DVNDN P+ + +
Sbjct: 195 VLEGTLDREG-EAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQ-PVYRVSVP 252
Query: 806 DCFPVG-PFGRVPAYDAD--VTDKLQYRI--LSGNNANLILLNETTGSMTLSPQLNTNVP 860
+ PVG P V A D D V ++ Y ++ + + LN TG ++ S L+
Sbjct: 253 ENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDS 312
Query: 861 KLATMEVSVTDG 872
+ V DG
Sbjct: 313 SFYELGVEARDG 324
>AF152326-1|AAD43720.1| 932|Homo sapiens protocadherin gamma A6
protein.
Length = 932
Score = 239 bits (585), Expect = 1e-61
Identities = 189/609 (31%), Positives = 292/609 (47%), Gaps = 34/609 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ R+G+L+T +DRE++ + + V D+L+ + V I+D NDN P
Sbjct: 74 LFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNIL-VEDKLN-LYPVEVEIVDINDNTP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
+F ++ V + E+ + + + ++ D DVG NS + + GN+ + S +
Sbjct: 132 RFLKEELEVKILENAAPSSRFPLMEVY--DPDVGMNSLQGFKL-SGNSHFSVDVQSEAHG 188
Query: 208 ----DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
++ L TLD E YRLV+ A DGG P RS+ Q+L+ + DVNDN P F +++
Sbjct: 189 PKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYR 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
SV EN+P+G ++ V A D DEGV+ E+TY+ T + ++ +G + TS
Sbjct: 249 VSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFV--KITEKISQIFCLNVLTGEISTSAN 306
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E + Y+L V A DG A G + AE PPGT
Sbjct: 307 LDYEDSSFYELGVEARDGPGLRDRAKVLITILDVNDNVPEVVVTSGSRTI--AESAPPGT 364
Query: 384 PVVTLTATDADEDNRLHYEITGGNTRG-RFSITSQNGR--GLITVAQPLDFKQERRYVLT 440
+ D D+ L+ +T R F + G L+T A LD ++ Y +T
Sbjct: 365 VIALFQV--FDRDSGLNGLVTCSIPRSLPFELEKSVGNYYRLVTNA-ALDREEVFLYNIT 421
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+ATD G S ++ +N+ D N+ P F ++ Y+ V E+ P G ++ V+A D DV
Sbjct: 422 VTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDV 481
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NAQ++YSL+ + A IN TG + + D E + L VTA D G
Sbjct: 482 DQNAQVSYSLAEDTLQGAPL--SSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGD 539
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADVG 611
P LS + + V+D NDN P + L T A G V++V A D D G
Sbjct: 540 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG 599
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSST 670
N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+T
Sbjct: 600 QNAWLSYRL-LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSAT 657
Query: 671 VIVHIKIED 679
V + + + D
Sbjct: 658 VTLTVAVAD 666
Score = 206 bits (504), Expect = 7e-52
Identities = 176/599 (29%), Positives = 272/599 (45%), Gaps = 36/599 (6%)
Query: 310 TIDPRSGWVYTSGQLDRETQ-AKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
+++PR+G + T+G++DRE A+ + + + + F+
Sbjct: 76 SLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFLK 135
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQ-NGRGL--IT 424
+ EV++ E+ P + + D D N L GN+ + S+ +G +
Sbjct: 136 EELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPELV 195
Query: 425 VAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+ LD + E Y L ++A D G RS A + + + D N+ P+F Y SV E+
Sbjct: 196 LEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENL 255
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
P+GT VL V+ATD D G++ ++TYS E ++ Q F +N TG I+T+ LD E
Sbjct: 256 PVGTPVLAVTATDQDEGVHGEVTYSFVK--ITEKIS---QIFCLNVLTGEISTSANLDYE 310
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
S Y L V ARDG P L D V I+++DVNDN P + I E A GT ++
Sbjct: 311 DSSFYELGVEARDG--PGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIAL 368
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV---IRTNKALDRESVATHDLKAVA 659
D D GLNG + + P+ F ++ + G + TN ALDRE V +++ A
Sbjct: 369 FQVFDRDSGLNGLVTCSI-PRSLP---FELEKSVGNYYRLVTNAALDREEVFLYNITVTA 424
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D GTPP S+ I+ + + D ND+PP F + Y+ EN+P G +I + A DPD N
Sbjct: 425 TDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQN 484
Query: 720 AVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWN 776
A V YS+ S SD L + DYE R V + S PPL +
Sbjct: 485 AQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGDPPLSS 544
Query: 777 DVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------DADVTDK 826
+V + + V D NDNAP + + + + + P P Y D+
Sbjct: 545 NVSLSLFVLDQNDNAPEIL-YPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAW 603
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSV 884
L YR+L + L + TG + + L ++ V+V D G + A + L+V
Sbjct: 604 LSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTV 662
Score = 195 bits (475), Expect = 2e-48
Identities = 166/584 (28%), Positives = 264/584 (45%), Gaps = 57/584 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND++P F ++ E + E A+ + ++ D D+G N+ + + + +
Sbjct: 120 EVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFS 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
++ + + L+ +LDRE A Y +++ A D PV
Sbjct: 180 VDVQSEAH---------------GPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVR-- 222
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SS A I V ++D NDN P F++ Y VSV E++ V PV+A + ATD D G + + Y
Sbjct: 223 -SSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPV-GTPVLA-VTATDQDEGVHGEVTY 279
Query: 190 AIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + ++ F ++ L+G++S LDYE Y L + A+DG P + ++LI I
Sbjct: 280 SFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDG--PGLRDRAKVLITI 337
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
DVNDN P + +++E+ P G I Q +D D G+N +T ++ L
Sbjct: 338 LDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPR-------SL 390
Query: 308 PITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
P ++ G Y T+ LDRE Y + VTATD G PP S
Sbjct: 391 PFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPP 450
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDN--RLHYEITGGNTRGR--FSITSQNG- 419
F Y V + E+ P G + ++ A D D D ++ Y + +G S S N
Sbjct: 451 TFPHSSYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSD 510
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPYT 475
G++ + D++Q R L V+A+DSG S + + + D N+ AP ++ P
Sbjct: 511 TGILYALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTD 570
Query: 476 ASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
S E AP G V V A D D G NA ++Y L A F + T
Sbjct: 571 GSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK-------ASEPGLFSVGLHT 623
Query: 531 GAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
G + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 624 GEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 118 bits (285), Expect = 2e-25
Identities = 88/283 (31%), Positives = 134/283 (47%), Gaps = 22/283 (7%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP+ G++ T +DRE + + + + V + VE+ +VD+NDN P
Sbjct: 73 QLFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPR 132
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLN--------GRIHYELDPKDREEGSFVI 632
F ++ I+E+A + + D DVG+N G H+ +D + G
Sbjct: 133 FLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHG---- 188
Query: 633 DPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL 692
P + LDRE A + L A+DGG P +SS + + + D+ND+ P+F
Sbjct: 189 -PKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVY 247
Query: 693 TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYS-IKGGDD-SNSFSLETRQGSDKAELVT 750
+ EN P+GT + + A D DEG + V YS +K + S F L G E+ T
Sbjct: 248 RVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTG----EIST 303
Query: 751 MVDLDYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
+LDYE YEL + A P L + +V I + DVNDN P
Sbjct: 304 SANLDYED-SSFYELGVEARDGPGLRDRAKVLITILDVNDNVP 345
Score = 66.5 bits (155), Expect = 1e-09
Identities = 65/252 (25%), Positives = 109/252 (43%), Gaps = 11/252 (4%)
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKA-VAIDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F ++P +G + T +DRE + + V+ + + + V ++I DIND+ P F
Sbjct: 75 FSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFL 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAEL 748
+ L I EN+ + + +DPD G N++ + + G + G EL
Sbjct: 135 KEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPEL 194
Query: 749 VTMVDLDYESPRKKYELVIRA--ASPPLWNDV-RVEILVTDVNDNAPVMKDFQIIFNNYK 805
V LD E Y LV+ A P+ + V ++ + V DVNDN P+ + +
Sbjct: 195 VLEGTLDREG-EAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQ-PVYRVSVP 252
Query: 806 DCFPVG-PFGRVPAYDAD--VTDKLQYRI--LSGNNANLILLNETTGSMTLSPQLNTNVP 860
+ PVG P V A D D V ++ Y ++ + + LN TG ++ S L+
Sbjct: 253 ENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDS 312
Query: 861 KLATMEVSVTDG 872
+ V DG
Sbjct: 313 SFYELGVEARDG 324
>AB209178-1|BAD92415.1| 950|Homo sapiens protocadherin gamma
subfamily A, 6 isoform 1 precursor variant protein.
Length = 950
Score = 237 bits (579), Expect = 5e-61
Identities = 188/609 (30%), Positives = 291/609 (47%), Gaps = 34/609 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ R+G+L+T +DRE++ + + V D+L+ + V I+D NDN P
Sbjct: 92 LFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNIL-VEDKLN-LYPVEVEIVDINDNTP 149
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
+F ++ V + E+ + + + ++ D DVG NS + + GN+ + S +
Sbjct: 150 RFLKEELEVKILENAAPSSRFPLMEVY--DPDVGMNSLQGFKL-SGNSHFSVDVQSEAHG 206
Query: 208 ----DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
++ L TLD E YRLV+ A DGG P RS+ Q+L+ + DVNDN P F +++
Sbjct: 207 PKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYR 266
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
SV EN+P+G ++ V A D DEGV+ E+TY+ T + ++ +G + TS
Sbjct: 267 VSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFV--KITEKISQIFCLNVLTGEISTSAN 324
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E + Y+L V A DG A G + AE PPGT
Sbjct: 325 LDYEDSSFYELGVEARDGPGLRDRAKVLITILDVNDNVPEVVVTSGSRTI--AESAPPGT 382
Query: 384 PVVTLTATDADEDNRLHYEITGGNTRG-RFSITSQNGR--GLITVAQPLDFKQERRYVLT 440
+ D D+ L+ +T R F + G L+T A LD ++ Y +T
Sbjct: 383 VIALFQV--FDRDSGLNGLVTCSIPRSLPFELEKSVGNYYRLVTNA-ALDREEVFLYNIT 439
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+ATD G S ++ +N+ D N+ P F ++ Y+ V E+ P G ++ V+A D DV
Sbjct: 440 VTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDV 499
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NAQ++YSL+ + A IN TG + + D E + L VTA D G
Sbjct: 500 DQNAQVSYSLAEDTLQGAPL--SSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGD 557
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADVG 611
P LS + + V+D NDN P + L T A G V++V A D D G
Sbjct: 558 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG 617
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSST 670
N + Y L K E G F + +G +R +A LDR+++ + AV D G PP S+T
Sbjct: 618 QNAWLSYRL-LKASEPGLFSVGLHTGEVRMARALLDRDALKQSLVVAVQ-DHGQPPLSAT 675
Query: 671 VIVHIKIED 679
V + + + D
Sbjct: 676 VTLTVAVAD 684
Score = 208 bits (507), Expect = 3e-52
Identities = 176/599 (29%), Positives = 273/599 (45%), Gaps = 36/599 (6%)
Query: 310 TIDPRSGWVYTSGQLDRETQ-AKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
+++PR+G + T+G++DRE A+ + + + + F+
Sbjct: 94 SLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFLK 153
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQ-NGRGL--IT 424
+ EV++ E+ P + + D D N L GN+ + S+ +G +
Sbjct: 154 EELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPELV 213
Query: 425 VAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDA 482
+ LD + E Y L ++A D G RS A + + + D N+ P+F Y SV E+
Sbjct: 214 LEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENL 273
Query: 483 PIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
P+GT VL V+ATD D G++ ++TYS E ++ Q F +N TG I+T+ LD E
Sbjct: 274 PVGTPVLAVTATDQDEGVHGEVTYSFVK--ITEKIS---QIFCLNVLTGEISTSANLDYE 328
Query: 543 TMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQ 602
S Y L V ARDG P L D V I+++DVNDN P + I E A GT ++
Sbjct: 329 DSSFYELGVEARDG--PGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIAL 386
Query: 603 VGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV---IRTNKALDRESVATHDLKAVA 659
D D GLNG + + P+ F ++ + G + TN ALDRE V +++ A
Sbjct: 387 FQVFDRDSGLNGLVTCSI-PRSLP---FELEKSVGNYYRLVTNAALDREEVFLYNITVTA 442
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D GTPP S+ I+ + + D ND+PP F + Y+ EN+P G +I + A DPD N
Sbjct: 443 TDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQN 502
Query: 720 AVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPLWN 776
A V YS+ S SD L + DYE R V + S PPL +
Sbjct: 503 AQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGDPPLSS 562
Query: 777 DVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------DADVTDK 826
+V + + V D NDNAP + + + + + P P Y D+
Sbjct: 563 NVSLSLFVLDQNDNAPEIL-YPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAW 621
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSV 884
L YR+L + L + TG + ++ L ++ V+V D G + A + L+V
Sbjct: 622 LSYRLLKASEPGLFSVGLHTGEVRMARALLDRDALKQSLVVAVQDHGQPPLSATVTLTV 680
Score = 192 bits (469), Expect = 1e-47
Identities = 165/584 (28%), Positives = 263/584 (45%), Gaps = 57/584 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND++P F ++ E + E A+ + ++ D D+G N+ + + + +
Sbjct: 138 EVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFS 197
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
++ + + L+ +LDRE A Y +++ A D PV
Sbjct: 198 VDVQSEAH---------------GPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVR-- 240
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
SS A I V ++D NDN P F++ Y VSV E++ V PV+A + ATD D G + + Y
Sbjct: 241 -SSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPV-GTPVLA-VTATDQDEGVHGEVTY 297
Query: 190 AIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + ++ F ++ L+G++S LDYE Y L + A+DG P + ++LI I
Sbjct: 298 SFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDG--PGLRDRAKVLITI 355
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDL 307
DVNDN P + +++E+ P G I Q +D D G+N +T ++ L
Sbjct: 356 LDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPR-------SL 408
Query: 308 PITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
P ++ G Y T+ LDRE Y + VTATD G PP S
Sbjct: 409 PFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPP 468
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDN--RLHYEITGGNTRGR--FSITSQNG- 419
F Y V + E+ P G + ++ A D D D ++ Y + +G S S N
Sbjct: 469 TFPHSSYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSD 528
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPYT 475
G++ + D++Q R L V+A+DSG S + + + D N+ AP ++ P
Sbjct: 529 TGILYALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTD 588
Query: 476 ASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
S E AP G V V A D D G NA ++Y L A F + T
Sbjct: 589 GSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK-------ASEPGLFSVGLHT 641
Query: 531 GAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
G + LLDR+ + L V +D G P LS T + ++V D
Sbjct: 642 GEVRMARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 684
Score = 118 bits (285), Expect = 2e-25
Identities = 88/283 (31%), Positives = 134/283 (47%), Gaps = 22/283 (7%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP+ G++ T +DRE + + + + V + VE+ +VD+NDN P
Sbjct: 91 QLFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPR 150
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLN--------GRIHYELDPKDREEGSFVI 632
F ++ I+E+A + + D DVG+N G H+ +D + G
Sbjct: 151 FLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHG---- 206
Query: 633 DPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL 692
P + LDRE A + L A+DGG P +SS + + + D+ND+ P+F
Sbjct: 207 -PKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVY 265
Query: 693 TFYISENSPIGTTIGEIRAHDPDEGPNAVVHYS-IKGGDD-SNSFSLETRQGSDKAELVT 750
+ EN P+GT + + A D DEG + V YS +K + S F L G E+ T
Sbjct: 266 RVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTG----EIST 321
Query: 751 MVDLDYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
+LDYE YEL + A P L + +V I + DVNDN P
Sbjct: 322 SANLDYED-SSFYELGVEARDGPGLRDRAKVLITILDVNDNVP 363
Score = 66.5 bits (155), Expect = 1e-09
Identities = 65/252 (25%), Positives = 109/252 (43%), Gaps = 11/252 (4%)
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKA-VAIDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F ++P +G + T +DRE + + V+ + + + V ++I DIND+ P F
Sbjct: 93 FSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFL 152
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAEL 748
+ L I EN+ + + +DPD G N++ + + G + G EL
Sbjct: 153 KEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPEL 212
Query: 749 VTMVDLDYESPRKKYELVIRA--ASPPLWNDV-RVEILVTDVNDNAPVMKDFQIIFNNYK 805
V LD E Y LV+ A P+ + V ++ + V DVNDN P+ + +
Sbjct: 213 VLEGTLDREG-EAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQ-PVYRVSVP 270
Query: 806 DCFPVG-PFGRVPAYDAD--VTDKLQYRI--LSGNNANLILLNETTGSMTLSPQLNTNVP 860
+ PVG P V A D D V ++ Y ++ + + LN TG ++ S L+
Sbjct: 271 ENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDS 330
Query: 861 KLATMEVSVTDG 872
+ V DG
Sbjct: 331 SFYELGVEARDG 342
>BC113460-1|AAI13461.1| 813|Homo sapiens protocadherin gamma
subfamily A, 5 protein.
Length = 813
Score = 235 bits (576), Expect = 1e-60
Identities = 186/610 (30%), Positives = 291/610 (47%), Gaps = 36/610 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + L V +++ + V IID NDN+P
Sbjct: 74 LFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNIL-VENKMKIYG-VEVEIIDINDNFP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
+F ++ V V+E+ + V+ A DADVG NS Y + ++ + FS+D +SG
Sbjct: 132 RFRDEELKVKVNENAAAGTRLVLPF--ARDADVGVNSLRSYQL---SSNLHFSLDVVSGT 186
Query: 208 ------DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
++ L + LD E+ + L++ A DGG P S TT + + + D NDNAP F S
Sbjct: 187 DGQKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+ SV EN+P+G ++ + A D DEG+N +LTY+ +++ + +D G + T
Sbjct: 247 YSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEE--EKISETFQLDSNLGEISTL 304
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E Y + V A DGG A+A + ++ED P
Sbjct: 305 QSLDYEESRFYLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLP 362
Query: 382 GTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GT + + D D E+ + I N + + N L+T + LD ++ Y +
Sbjct: 363 GTVIALFSVHDGDSGENGEIACSIP-RNLPFKLEKSVDNYYHLLT-TRDLDREETSDYNI 420
Query: 440 TVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
T++ D G S + + + + D N+ P F A Y+ SV E+ P G ++ V+A D D
Sbjct: 421 TLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPD 480
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G NA++TYSL+ + A IN TG + + D E + L VTA D G
Sbjct: 481 SGDNARVTYSLAEDTFQGAPL--SSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSG 538
Query: 558 VPSLSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADV 610
P LS + + V+D NDN P + L T A G V++V A D D
Sbjct: 539 NPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDS 598
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSS 669
G N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+
Sbjct: 599 GQNAWLSYRL-LKASEPGLFAVGLHTGEVRTARALLDRDALKQSLVVAVE-DHGQPPLSA 656
Query: 670 TVIVHIKIED 679
T V + + D
Sbjct: 657 TFTVTVAVAD 666
Score = 218 bits (532), Expect = 3e-55
Identities = 172/609 (28%), Positives = 276/609 (45%), Gaps = 28/609 (4%)
Query: 194 GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYR-LVIRAQDGGSPSRSNTTQLLINIRDVND 252
G TQ+ F+++ SG + +D E++ + L + + ++ + + I D+ND
Sbjct: 70 GRTQL-FALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDIND 128
Query: 253 NAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITID 312
N PRF + V+EN G +V A DAD GVN+ +Y ++ + + T
Sbjct: 129 NFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDG 188
Query: 313 PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYE 372
+ + LDRE + + LL+TA DGGDP S T F P +Y
Sbjct: 189 QKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYS 248
Query: 373 VELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLD 430
V + E+ P GT ++ LTATD DE + +L Y + + + G I+ Q LD
Sbjct: 249 VSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLD 308
Query: 431 FKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLV 490
+++ R Y++ V A D G +A V + + D N+ AP T+S+ ED GT + +
Sbjct: 309 YEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIAL 368
Query: 491 VSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLT 550
S D D G N +I S+ + + D + + T + LDRE S Y +T
Sbjct: 369 FSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYY-------HLLTTRDLDREETSDYNIT 421
Query: 551 VTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADV 610
+T D G P LS + + + V DVNDN P F Q Y+ ++ E+ G S+ V A D D
Sbjct: 422 LTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDS 481
Query: 611 GLNGRIHYELDPKDREEG----SFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
G N R+ Y L +D +G S+V I+ +GV+ ++ D E + L A D G P
Sbjct: 482 GDNARVTYSL-AEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNP 540
Query: 666 PQSSTVIVHIKIEDINDSPP-----VFESDCLTFY--ISENSPIGTTIGEIRAHDPDEGP 718
P SS V + + + D ND+ P +D T ++ G + ++ A D D G
Sbjct: 541 PLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQ 600
Query: 719 NAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWND 777
NA + Y + + F++ G + LD ++ ++ + + PPL
Sbjct: 601 NAWLSYRLLKASEPGLFAVGLHTGEVRTARAL---LDRDALKQSLVVAVEDHGQPPLSAT 657
Query: 778 VRVEILVTD 786
V + V D
Sbjct: 658 FTVTVAVAD 666
Score = 213 bits (521), Expect = 6e-54
Identities = 152/492 (30%), Positives = 249/492 (50%), Gaps = 18/492 (3%)
Query: 311 IDPRSGWVYTSGQLDRETQ-AKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE A+ L V + + F
Sbjct: 77 LNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFRDE 136
Query: 370 QYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL--ITV 425
+ +V++ E+ GT +V A DAD N L Y+++ ++ +G+ + +
Sbjct: 137 ELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDGQKYPELVL 196
Query: 426 AQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
QPLD ++E + L ++A D G S T +++ + DAN+ AP+F + Y+ SV E+ P
Sbjct: 197 EQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIP 256
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
+GT +L+++ATD D GIN ++TYS +E E ++ + F ++ G I+T + LD E
Sbjct: 257 VGTRLLMLTATDPDEGINGKLTYSFRNE--EEKIS---ETFQLDSNLGEISTLQSLDYEE 311
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
YL+ V A+DGG +L + V ++V DVNDN P T++I ED L GT ++
Sbjct: 312 SRFYLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIALF 369
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
D D G NG I + + +D ++ T + LDRE + +++ +D G
Sbjct: 370 SVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLL-TTRDLDREETSDYNITLTVMDHG 428
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVH 723
TPP S+ + +K+ D+ND+PP F + ++EN+P G +I + AHDPD G NA V
Sbjct: 429 TPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVT 488
Query: 724 YSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPR--KKYELVIRAASPPLWNDVRV 780
YS+ + S SD L + DYE R + + + +PPL ++V +
Sbjct: 489 YSLAEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSL 548
Query: 781 EILVTDVNDNAP 792
+ V D NDN P
Sbjct: 549 SLFVLDQNDNTP 560
Score = 198 bits (483), Expect = 2e-49
Identities = 171/585 (29%), Positives = 263/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND+ P F ++ + V E A++GT ++ A D D+G N+ Y +
Sbjct: 120 EVEIIDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQL------- 172
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ V DG+ L+ LDREK + +L+ A D PV
Sbjct: 173 ---------SSNLHFSLDVVSGTDGQKYPELVLEQPLDREKETVHDLLLTALDGGDPV-- 221
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
LS T I V ++D NDN P F+ Y+VSV E+I V + + ATD D G N +
Sbjct: 222 -LSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTR--LLMLTATDPDEGINGKLT 278
Query: 189 YAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ ++ F +DS G++S +++LDYE+ R Y + + AQDGG+ S ++++
Sbjct: 279 YSFRNEEEKISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGALVAS--AKVVVT 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
++DVNDNAP + S+SE+ G I +D D G N E+ ++ +
Sbjct: 337 VQDVNDNAPEVILTSLTSSISEDCLPGTVIALFSVHDGDSGENGEIACSIPR-------N 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ Y T+ LDRE + Y + +T D G PP S +
Sbjct: 390 LPFKLEKSVDNYYHLLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G + ++TA D D DN R+ Y + +G S S N
Sbjct: 450 PNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINS 509
Query: 420 -RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ + D++Q R L V+A+DSG S + + + D N+ P ++ P
Sbjct: 510 DTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPT 569
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 570 DGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLK-------ASEPGLFAVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V D G P LS T V ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QSLVVAVEDHGQPPLSATFTVTVAVAD 666
Score = 165 bits (401), Expect = 2e-39
Identities = 135/497 (27%), Positives = 218/497 (43%), Gaps = 38/497 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ VLD ND++P+F +Y SV E GT +L L ATD D G N ++ Y+
Sbjct: 227 HIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFR---- 282
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
N E+ + + F++D G + T SLD E+ Y + V A D +
Sbjct: 283 ---NEEE----------KISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGA--- 326
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L ++A + V + D NDN P+ + T S+ ED VIA D D G N I
Sbjct: 327 --LVASAKVVVTVQDVNDNAPEVILTSLTSSISED--CLPGTVIALFSVHDGDSGENGEI 382
Query: 188 RYAIIGG-NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+I +++ S+D+ + + LD E+ Y + + D G+P S + + +
Sbjct: 383 ACSIPRNLPFKLEKSVDNYY-HLLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLK 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ DVNDN P F + + SV+EN P G SI V A+D D G NA +TY++ + + G +
Sbjct: 442 VADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E QL VTA+D G+PP S+ +
Sbjct: 502 SSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPE 561
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G VELA PG V + A D D L Y + + G F++
Sbjct: 562 ILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTA 476
G + A+ L + + L V+ D G +A + + A+ + +
Sbjct: 622 HTGE--VRTARALLDRDALKQSLVVAVEDHGQPPLSATFTVTVAVADRIPDILADLGSIK 679
Query: 477 SVFEDAPIGTTVLVVSA 493
+ + + T+ +V A
Sbjct: 680 TPIDPEDLDLTLYLVVA 696
Score = 144 bits (350), Expect = 3e-33
Identities = 97/311 (31%), Positives = 148/311 (47%), Gaps = 18/311 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP++G++ T +DRE + L V + V + VE+ ++D+NDN P
Sbjct: 73 QLFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPR 132
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV-- 638
F+ + + E+A GT + A DADVG+N Y+L F +D SG
Sbjct: 133 FRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLH----FSLDVVSGTDG 188
Query: 639 -----IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+ + LDRE HDL A+DGG P S T + + + D ND+ P+F +
Sbjct: 189 QKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYS 248
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTM 751
+ EN P+GT + + A DPDEG N + YS + ++ S +F L++ G E+ T+
Sbjct: 249 VSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLG----EISTL 304
Query: 752 VDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
LDYE R V+ L +V + V DVNDNAP + + + +DC P
Sbjct: 305 QSLDYEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGT 364
Query: 812 PFGRVPAYDAD 822
+D D
Sbjct: 365 VIALFSVHDGD 375
Score = 66.5 bits (155), Expect = 1e-09
Identities = 75/289 (25%), Positives = 128/289 (44%), Gaps = 21/289 (7%)
Query: 630 FVIDPASGVIRTNKALDRESV-ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F ++P SG + T +DRE + A L V + + V ++I DIND+ P F
Sbjct: 75 FALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFR 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSD---K 745
+ L ++EN+ GT + A D D G N++ Y + + FSL+ G+D
Sbjct: 135 DEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQL---SSNLHFSLDVVSGTDGQKY 191
Query: 746 AELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
ELV LD E ++L++ A P L + + V D NDNAP+ +
Sbjct: 192 PELVLEQPLDREK-ETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSV- 249
Query: 803 NYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNT 857
+ + PVG + A D D + KL Y + + L+ G ++ L+
Sbjct: 250 SVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLDY 309
Query: 858 NVPKLATMEVSVTDGVNEI-KAMMQLSVRLITE---EMLLNSITVRLND 902
+ MEV DG + A + ++V+ + + E++L S+T +++
Sbjct: 310 EESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISE 358
>BC104926-1|AAI04927.1| 813|Homo sapiens protocadherin gamma
subfamily A, 5 protein.
Length = 813
Score = 235 bits (576), Expect = 1e-60
Identities = 186/610 (30%), Positives = 291/610 (47%), Gaps = 36/610 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + L V +++ + V IID NDN+P
Sbjct: 74 LFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNIL-VENKMKIYG-VEVEIIDINDNFP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
+F ++ V V+E+ + V+ A DADVG NS Y + ++ + FS+D +SG
Sbjct: 132 RFRDEELKVKVNENAAAGTRLVLPF--ARDADVGVNSLRSYQL---SSNLHFSLDVVSGT 186
Query: 208 ------DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
++ L + LD E+ + L++ A DGG P S TT + + + D NDNAP F S
Sbjct: 187 DGQKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+ SV EN+P+G ++ + A D DEG+N +LTY+ +++ + +D G + T
Sbjct: 247 YSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEE--EKISETFQLDSNLGEISTL 304
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E Y + V A DGG A+A + ++ED P
Sbjct: 305 QSLDYEESRFYLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLP 362
Query: 382 GTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GT + + D D E+ + I N + + N L+T + LD ++ Y +
Sbjct: 363 GTVIALFSVHDGDSGENGEIACSIP-RNLPFKLEKSVDNYYHLLT-TRDLDREETSDYNI 420
Query: 440 TVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
T++ D G S + + + + D N+ P F A Y+ SV E+ P G ++ V+A D D
Sbjct: 421 TLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPD 480
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G NA++TYSL+ + A IN TG + + D E + L VTA D G
Sbjct: 481 SGDNARVTYSLAEDTFQGAPL--SSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSG 538
Query: 558 VPSLSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADV 610
P LS + + V+D NDN P + L T A G V++V A D D
Sbjct: 539 NPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDS 598
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSS 669
G N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+
Sbjct: 599 GQNAWLSYRL-LKASEPGLFAVGLHTGEVRTARALLDRDALKQSLVVAVE-DHGQPPLSA 656
Query: 670 TVIVHIKIED 679
T V + + D
Sbjct: 657 TFTVTVAVAD 666
Score = 218 bits (532), Expect = 3e-55
Identities = 172/609 (28%), Positives = 276/609 (45%), Gaps = 28/609 (4%)
Query: 194 GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYR-LVIRAQDGGSPSRSNTTQLLINIRDVND 252
G TQ+ F+++ SG + +D E++ + L + + ++ + + I D+ND
Sbjct: 70 GRTQL-FALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDIND 128
Query: 253 NAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITID 312
N PRF + V+EN G +V A DAD GVN+ +Y ++ + + T
Sbjct: 129 NFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDG 188
Query: 313 PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYE 372
+ + LDRE + + LL+TA DGGDP S T F P +Y
Sbjct: 189 QKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYS 248
Query: 373 VELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLD 430
V + E+ P GT ++ LTATD DE + +L Y + + + G I+ Q LD
Sbjct: 249 VSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLD 308
Query: 431 FKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLV 490
+++ R Y++ V A D G +A V + + D N+ AP T+S+ ED GT + +
Sbjct: 309 YEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIAL 368
Query: 491 VSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLT 550
S D D G N +I S+ + + D + + T + LDRE S Y +T
Sbjct: 369 FSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYY-------HLLTTRDLDREETSDYNIT 421
Query: 551 VTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADV 610
+T D G P LS + + + V DVNDN P F Q Y+ ++ E+ G S+ V A D D
Sbjct: 422 LTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDS 481
Query: 611 GLNGRIHYELDPKDREEG----SFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
G N R+ Y L +D +G S+V I+ +GV+ ++ D E + L A D G P
Sbjct: 482 GDNARVTYSL-AEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNP 540
Query: 666 PQSSTVIVHIKIEDINDSPP-----VFESDCLTFY--ISENSPIGTTIGEIRAHDPDEGP 718
P SS V + + + D ND+ P +D T ++ G + ++ A D D G
Sbjct: 541 PLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQ 600
Query: 719 NAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWND 777
NA + Y + + F++ G + LD ++ ++ + + PPL
Sbjct: 601 NAWLSYRLLKASEPGLFAVGLHTGEVRTARAL---LDRDALKQSLVVAVEDHGQPPLSAT 657
Query: 778 VRVEILVTD 786
V + V D
Sbjct: 658 FTVTVAVAD 666
Score = 213 bits (521), Expect = 6e-54
Identities = 152/492 (30%), Positives = 249/492 (50%), Gaps = 18/492 (3%)
Query: 311 IDPRSGWVYTSGQLDRETQ-AKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE A+ L V + + F
Sbjct: 77 LNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFRDE 136
Query: 370 QYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL--ITV 425
+ +V++ E+ GT +V A DAD N L Y+++ ++ +G+ + +
Sbjct: 137 ELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDGQKYPELVL 196
Query: 426 AQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
QPLD ++E + L ++A D G S T +++ + DAN+ AP+F + Y+ SV E+ P
Sbjct: 197 EQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIP 256
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
+GT +L+++ATD D GIN ++TYS +E E ++ + F ++ G I+T + LD E
Sbjct: 257 VGTRLLMLTATDPDEGINGKLTYSFRNE--EEKIS---ETFQLDSNLGEISTLQSLDYEE 311
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
YL+ V A+DGG +L + V ++V DVNDN P T++I ED L GT ++
Sbjct: 312 SRFYLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIALF 369
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
D D G NG I + + +D ++ T + LDRE + +++ +D G
Sbjct: 370 SVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLL-TTRDLDREETSDYNITLTVMDHG 428
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVH 723
TPP S+ + +K+ D+ND+PP F + ++EN+P G +I + AHDPD G NA V
Sbjct: 429 TPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVT 488
Query: 724 YSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPR--KKYELVIRAASPPLWNDVRV 780
YS+ + S SD L + DYE R + + + +PPL ++V +
Sbjct: 489 YSLAEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSL 548
Query: 781 EILVTDVNDNAP 792
+ V D NDN P
Sbjct: 549 SLFVLDQNDNTP 560
Score = 198 bits (483), Expect = 2e-49
Identities = 171/585 (29%), Positives = 263/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND+ P F ++ + V E A++GT ++ A D D+G N+ Y +
Sbjct: 120 EVEIIDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQL------- 172
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ V DG+ L+ LDREK + +L+ A D PV
Sbjct: 173 ---------SSNLHFSLDVVSGTDGQKYPELVLEQPLDREKETVHDLLLTALDGGDPV-- 221
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
LS T I V ++D NDN P F+ Y+VSV E+I V + + ATD D G N +
Sbjct: 222 -LSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTR--LLMLTATDPDEGINGKLT 278
Query: 189 YAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ ++ F +DS G++S +++LDYE+ R Y + + AQDGG+ S ++++
Sbjct: 279 YSFRNEEEKISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGALVAS--AKVVVT 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
++DVNDNAP + S+SE+ G I +D D G N E+ ++ +
Sbjct: 337 VQDVNDNAPEVILTSLTSSISEDCLPGTVIALFSVHDGDSGENGEIACSIPR-------N 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ Y T+ LDRE + Y + +T D G PP S +
Sbjct: 390 LPFKLEKSVDNYYHLLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G + ++TA D D DN R+ Y + +G S S N
Sbjct: 450 PNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINS 509
Query: 420 -RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ + D++Q R L V+A+DSG S + + + D N+ P ++ P
Sbjct: 510 DTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPT 569
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 570 DGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLK-------ASEPGLFAVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V D G P LS T V ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QSLVVAVEDHGQPPLSATFTVTVAVAD 666
Score = 165 bits (401), Expect = 2e-39
Identities = 135/497 (27%), Positives = 218/497 (43%), Gaps = 38/497 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ VLD ND++P+F +Y SV E GT +L L ATD D G N ++ Y+
Sbjct: 227 HIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFR---- 282
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
N E+ + + F++D G + T SLD E+ Y + V A D +
Sbjct: 283 ---NEEE----------KISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGA--- 326
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L ++A + V + D NDN P+ + T S+ ED VIA D D G N I
Sbjct: 327 --LVASAKVVVTVQDVNDNAPEVILTSLTSSISED--CLPGTVIALFSVHDGDSGENGEI 382
Query: 188 RYAIIGG-NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+I +++ S+D+ + + LD E+ Y + + D G+P S + + +
Sbjct: 383 ACSIPRNLPFKLEKSVDNYY-HLLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLK 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ DVNDN P F + + SV+EN P G SI V A+D D G NA +TY++ + + G +
Sbjct: 442 VADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E QL VTA+D G+PP S+ +
Sbjct: 502 SSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPE 561
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G VELA PG V + A D D L Y + + G F++
Sbjct: 562 ILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTA 476
G + A+ L + + L V+ D G +A + + A+ + +
Sbjct: 622 HTGE--VRTARALLDRDALKQSLVVAVEDHGQPPLSATFTVTVAVADRIPDILADLGSIK 679
Query: 477 SVFEDAPIGTTVLVVSA 493
+ + + T+ +V A
Sbjct: 680 TPIDPEDLDLTLYLVVA 696
Score = 144 bits (350), Expect = 3e-33
Identities = 97/311 (31%), Positives = 148/311 (47%), Gaps = 18/311 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP++G++ T +DRE + L V + V + VE+ ++D+NDN P
Sbjct: 73 QLFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPR 132
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV-- 638
F+ + + E+A GT + A DADVG+N Y+L F +D SG
Sbjct: 133 FRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLH----FSLDVVSGTDG 188
Query: 639 -----IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+ + LDRE HDL A+DGG P S T + + + D ND+ P+F +
Sbjct: 189 QKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYS 248
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTM 751
+ EN P+GT + + A DPDEG N + YS + ++ S +F L++ G E+ T+
Sbjct: 249 VSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLG----EISTL 304
Query: 752 VDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
LDYE R V+ L +V + V DVNDNAP + + + +DC P
Sbjct: 305 QSLDYEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGT 364
Query: 812 PFGRVPAYDAD 822
+D D
Sbjct: 365 VIALFSVHDGD 375
Score = 66.5 bits (155), Expect = 1e-09
Identities = 75/289 (25%), Positives = 128/289 (44%), Gaps = 21/289 (7%)
Query: 630 FVIDPASGVIRTNKALDRESV-ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F ++P SG + T +DRE + A L V + + V ++I DIND+ P F
Sbjct: 75 FALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFR 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSD---K 745
+ L ++EN+ GT + A D D G N++ Y + + FSL+ G+D
Sbjct: 135 DEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQL---SSNLHFSLDVVSGTDGQKY 191
Query: 746 AELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
ELV LD E ++L++ A P L + + V D NDNAP+ +
Sbjct: 192 PELVLEQPLDREK-ETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSV- 249
Query: 803 NYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNT 857
+ + PVG + A D D + KL Y + + L+ G ++ L+
Sbjct: 250 SVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLDY 309
Query: 858 NVPKLATMEVSVTDGVNEI-KAMMQLSVRLITE---EMLLNSITVRLND 902
+ MEV DG + A + ++V+ + + E++L S+T +++
Sbjct: 310 EESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISE 358
>AF152512-1|AAD43772.1| 813|Homo sapiens protocadherin gamma A5
short form protein protein.
Length = 813
Score = 235 bits (576), Expect = 1e-60
Identities = 186/610 (30%), Positives = 291/610 (47%), Gaps = 36/610 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + L V +++ + V IID NDN+P
Sbjct: 74 LFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNIL-VENKMKIYG-VEVEIIDINDNFP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
+F ++ V V+E+ + V+ A DADVG NS Y + ++ + FS+D +SG
Sbjct: 132 RFRDEELKVKVNENAAAGTRLVLPF--ARDADVGVNSLRSYQL---SSNLHFSLDVVSGT 186
Query: 208 ------DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
++ L + LD E+ + L++ A DGG P S TT + + + D NDNAP F S
Sbjct: 187 DGQKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+ SV EN+P+G ++ + A D DEG+N +LTY+ +++ + +D G + T
Sbjct: 247 YSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEE--EKISETFQLDSNLGEISTL 304
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E Y + V A DGG A+A + ++ED P
Sbjct: 305 QSLDYEESRFYLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLP 362
Query: 382 GTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GT + + D D E+ + I N + + N L+T + LD ++ Y +
Sbjct: 363 GTVIALFSVHDGDSGENGEIACSIP-RNLPFKLEKSVDNYYHLLT-TRDLDREETSDYNI 420
Query: 440 TVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
T++ D G S + + + + D N+ P F A Y+ SV E+ P G ++ V+A D D
Sbjct: 421 TLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPD 480
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G NA++TYSL+ + A IN TG + + D E + L VTA D G
Sbjct: 481 SGDNARVTYSLAEDTFQGAPL--SSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSG 538
Query: 558 VPSLSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADV 610
P LS + + V+D NDN P + L T A G V++V A D D
Sbjct: 539 NPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDS 598
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSS 669
G N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+
Sbjct: 599 GQNAWLSYRL-LKASEPGLFAVGLHTGEVRTARALLDRDALKQSLVVAVE-DHGQPPLSA 656
Query: 670 TVIVHIKIED 679
T V + + D
Sbjct: 657 TFTVTVAVAD 666
Score = 218 bits (532), Expect = 3e-55
Identities = 172/609 (28%), Positives = 276/609 (45%), Gaps = 28/609 (4%)
Query: 194 GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYR-LVIRAQDGGSPSRSNTTQLLINIRDVND 252
G TQ+ F+++ SG + +D E++ + L + + ++ + + I D+ND
Sbjct: 70 GRTQL-FALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDIND 128
Query: 253 NAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITID 312
N PRF + V+EN G +V A DAD GVN+ +Y ++ + + T
Sbjct: 129 NFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDG 188
Query: 313 PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYE 372
+ + LDRE + + LL+TA DGGDP S T F P +Y
Sbjct: 189 QKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYS 248
Query: 373 VELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLD 430
V + E+ P GT ++ LTATD DE + +L Y + + + G I+ Q LD
Sbjct: 249 VSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLD 308
Query: 431 FKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLV 490
+++ R Y++ V A D G +A V + + D N+ AP T+S+ ED GT + +
Sbjct: 309 YEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIAL 368
Query: 491 VSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLT 550
S D D G N +I S+ + + D + + T + LDRE S Y +T
Sbjct: 369 FSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYY-------HLLTTRDLDREETSDYNIT 421
Query: 551 VTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADV 610
+T D G P LS + + + V DVNDN P F Q Y+ ++ E+ G S+ V A D D
Sbjct: 422 LTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDS 481
Query: 611 GLNGRIHYELDPKDREEG----SFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
G N R+ Y L +D +G S+V I+ +GV+ ++ D E + L A D G P
Sbjct: 482 GDNARVTYSL-AEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNP 540
Query: 666 PQSSTVIVHIKIEDINDSPP-----VFESDCLTFY--ISENSPIGTTIGEIRAHDPDEGP 718
P SS V + + + D ND+ P +D T ++ G + ++ A D D G
Sbjct: 541 PLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQ 600
Query: 719 NAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWND 777
NA + Y + + F++ G + LD ++ ++ + + PPL
Sbjct: 601 NAWLSYRLLKASEPGLFAVGLHTGEVRTARAL---LDRDALKQSLVVAVEDHGQPPLSAT 657
Query: 778 VRVEILVTD 786
V + V D
Sbjct: 658 FTVTVAVAD 666
Score = 213 bits (521), Expect = 6e-54
Identities = 152/492 (30%), Positives = 249/492 (50%), Gaps = 18/492 (3%)
Query: 311 IDPRSGWVYTSGQLDRETQ-AKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE A+ L V + + F
Sbjct: 77 LNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFRDE 136
Query: 370 QYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL--ITV 425
+ +V++ E+ GT +V A DAD N L Y+++ ++ +G+ + +
Sbjct: 137 ELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDGQKYPELVL 196
Query: 426 AQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
QPLD ++E + L ++A D G S T +++ + DAN+ AP+F + Y+ SV E+ P
Sbjct: 197 EQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIP 256
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
+GT +L+++ATD D GIN ++TYS +E E ++ + F ++ G I+T + LD E
Sbjct: 257 VGTRLLMLTATDPDEGINGKLTYSFRNE--EEKIS---ETFQLDSNLGEISTLQSLDYEE 311
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
YL+ V A+DGG +L + V ++V DVNDN P T++I ED L GT ++
Sbjct: 312 SRFYLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIALF 369
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
D D G NG I + + +D ++ T + LDRE + +++ +D G
Sbjct: 370 SVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLL-TTRDLDREETSDYNITLTVMDHG 428
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVH 723
TPP S+ + +K+ D+ND+PP F + ++EN+P G +I + AHDPD G NA V
Sbjct: 429 TPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVT 488
Query: 724 YSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPR--KKYELVIRAASPPLWNDVRV 780
YS+ + S SD L + DYE R + + + +PPL ++V +
Sbjct: 489 YSLAEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSL 548
Query: 781 EILVTDVNDNAP 792
+ V D NDN P
Sbjct: 549 SLFVLDQNDNTP 560
Score = 198 bits (483), Expect = 2e-49
Identities = 171/585 (29%), Positives = 263/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND+ P F ++ + V E A++GT ++ A D D+G N+ Y +
Sbjct: 120 EVEIIDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQL------- 172
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ V DG+ L+ LDREK + +L+ A D PV
Sbjct: 173 ---------SSNLHFSLDVVSGTDGQKYPELVLEQPLDREKETVHDLLLTALDGGDPV-- 221
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
LS T I V ++D NDN P F+ Y+VSV E+I V + + ATD D G N +
Sbjct: 222 -LSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTR--LLMLTATDPDEGINGKLT 278
Query: 189 YAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ ++ F +DS G++S +++LDYE+ R Y + + AQDGG+ S ++++
Sbjct: 279 YSFRNEEEKISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGALVAS--AKVVVT 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
++DVNDNAP + S+SE+ G I +D D G N E+ ++ +
Sbjct: 337 VQDVNDNAPEVILTSLTSSISEDCLPGTVIALFSVHDGDSGENGEIACSIPR-------N 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ Y T+ LDRE + Y + +T D G PP S +
Sbjct: 390 LPFKLEKSVDNYYHLLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G + ++TA D D DN R+ Y + +G S S N
Sbjct: 450 PNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINS 509
Query: 420 -RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ + D++Q R L V+A+DSG S + + + D N+ P ++ P
Sbjct: 510 DTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPT 569
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 570 DGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLK-------ASEPGLFAVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V D G P LS T V ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QSLVVAVEDHGQPPLSATFTVTVAVAD 666
Score = 165 bits (401), Expect = 2e-39
Identities = 135/497 (27%), Positives = 218/497 (43%), Gaps = 38/497 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ VLD ND++P+F +Y SV E GT +L L ATD D G N ++ Y+
Sbjct: 227 HIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFR---- 282
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
N E+ + + F++D G + T SLD E+ Y + V A D +
Sbjct: 283 ---NEEE----------KISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGA--- 326
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L ++A + V + D NDN P+ + T S+ ED VIA D D G N I
Sbjct: 327 --LVASAKVVVTVQDVNDNAPEVILTSLTSSISED--CLPGTVIALFSVHDGDSGENGEI 382
Query: 188 RYAIIGG-NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+I +++ S+D+ + + LD E+ Y + + D G+P S + + +
Sbjct: 383 ACSIPRNLPFKLEKSVDNYY-HLLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLK 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ DVNDN P F + + SV+EN P G SI V A+D D G NA +TY++ + + G +
Sbjct: 442 VADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E QL VTA+D G+PP S+ +
Sbjct: 502 SSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPE 561
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G VELA PG V + A D D L Y + + G F++
Sbjct: 562 ILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTA 476
G + A+ L + + L V+ D G +A + + A+ + +
Sbjct: 622 HTGE--VRTARALLDRDALKQSLVVAVEDHGQPPLSATFTVTVAVADRIPDILADLGSIK 679
Query: 477 SVFEDAPIGTTVLVVSA 493
+ + + T+ +V A
Sbjct: 680 TPIDPEDLDLTLYLVVA 696
Score = 144 bits (350), Expect = 3e-33
Identities = 97/311 (31%), Positives = 148/311 (47%), Gaps = 18/311 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP++G++ T +DRE + L V + V + VE+ ++D+NDN P
Sbjct: 73 QLFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPR 132
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV-- 638
F+ + + E+A GT + A DADVG+N Y+L F +D SG
Sbjct: 133 FRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLH----FSLDVVSGTDG 188
Query: 639 -----IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+ + LDRE HDL A+DGG P S T + + + D ND+ P+F +
Sbjct: 189 QKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYS 248
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTM 751
+ EN P+GT + + A DPDEG N + YS + ++ S +F L++ G E+ T+
Sbjct: 249 VSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLG----EISTL 304
Query: 752 VDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
LDYE R V+ L +V + V DVNDNAP + + + +DC P
Sbjct: 305 QSLDYEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGT 364
Query: 812 PFGRVPAYDAD 822
+D D
Sbjct: 365 VIALFSVHDGD 375
Score = 66.5 bits (155), Expect = 1e-09
Identities = 75/289 (25%), Positives = 128/289 (44%), Gaps = 21/289 (7%)
Query: 630 FVIDPASGVIRTNKALDRESV-ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F ++P SG + T +DRE + A L V + + V ++I DIND+ P F
Sbjct: 75 FALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFR 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSD---K 745
+ L ++EN+ GT + A D D G N++ Y + + FSL+ G+D
Sbjct: 135 DEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQL---SSNLHFSLDVVSGTDGQKY 191
Query: 746 AELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
ELV LD E ++L++ A P L + + V D NDNAP+ +
Sbjct: 192 PELVLEQPLDREK-ETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSV- 249
Query: 803 NYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNT 857
+ + PVG + A D D + KL Y + + L+ G ++ L+
Sbjct: 250 SVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLDY 309
Query: 858 NVPKLATMEVSVTDGVNEI-KAMMQLSVRLITE---EMLLNSITVRLND 902
+ MEV DG + A + ++V+ + + E++L S+T +++
Sbjct: 310 EESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISE 358
>AF152478-1|AAD43739.1| 807|Homo sapiens protocadherin alpha 13
short form protein protein.
Length = 807
Score = 235 bits (576), Expect = 1e-60
Identities = 175/614 (28%), Positives = 285/614 (46%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVEVKVRDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDS 204
P F E + + E S A+DAD+G NSA+ Y + + Q S++
Sbjct: 131 PIFPESKKRIIIAE--SRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQ 188
Query: 205 LSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
+S +SLV KTLD E+++ + L++ A DGG P + T QLLI I DVNDNAP FY S++
Sbjct: 189 MSS-LSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ +V EN G ++++ A D D+G N ++ Y+ + V TI+P +G + T G
Sbjct: 248 KVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPA-VVYAFTINPNNGEIRTKG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LD E + Y++ V A D G+ P + T + + ED P
Sbjct: 307 KLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPS 366
Query: 383 TPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ ++ +D D + T + + T +N L+ + LD + Y L V
Sbjct: 367 AIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQ 485
Query: 500 INAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD GV
Sbjct: 486 ENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSARDSGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVF------KQQLYTANIMEDAL-VGTSVSQVGATDADVG 611
P L +++ V+D NDN P + +M ++ G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL F + +G I T + LD H L + D G P ++T
Sbjct: 603 YNAWLSYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLLSLVESGQAP 676
Score = 200 bits (489), Expect = 4e-50
Identities = 147/500 (29%), Positives = 229/500 (45%), Gaps = 25/500 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F S + ++E+ P A DAD GVN+ LTY + DY
Sbjct: 121 VKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYF-T 179
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D +++ S + LDRE ++ LL+TA+DGG P + T
Sbjct: 180 LDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGR-FSITSQNGR 420
F Y+V + E+ GT V+ L ATD D+ + Y ++ T
Sbjct: 240 PEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNN 299
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASV 478
G I LDF++++ Y ++V A D G + + + + D N+ AP + +
Sbjct: 300 GEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPI 359
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED + ++S +D D G N Q+T +L+ + + V+ + + ++ +
Sbjct: 360 REDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYY-------SLVLDSA 412
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGC 472
Query: 599 SVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATHD 654
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 473 HIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQ 532
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTIG 707
+ A D G PP S V + + + D ND+ P + +SE P G +
Sbjct: 533 FQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVA 592
Query: 708 EIRAHDPDEGPNAVVHYSIK 727
++RA D D G NA + Y ++
Sbjct: 593 KVRAVDADSGYNAWLSYELQ 612
Score = 197 bits (480), Expect = 5e-49
Identities = 161/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ P+F + + E T A+D DIG N+ + Y ++
Sbjct: 118 HVEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
TL+ +++ S +L+ R +LDRE++ +++L+ A+D P
Sbjct: 178 FTLDAQNSLEQMS---------------SLSLVLRKTLDREEIQEHSLLLTASDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + I+D NDN P+F + Y V+V E + + ++ K+ ATD D G N I
Sbjct: 221 -ELTGTVQLLITILDVNDNAPEFYQSVYKVTVLE--NAFNGTLVIKLNATDPDDGTNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + F+I+ +G++ LD+E+ + Y + + A D G+ + LL
Sbjct: 278 VYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP + + E+ I + D D G N ++T T+T +
Sbjct: 338 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 393 VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHA 512
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF-----EN 471
G + QPLD ++ VSA DSG +Q+ + D N+ AP +
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGS 572
Query: 472 APYTASVFEDAPIGT--TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
A T S +G V V A D+D G NA ++Y L + F +
Sbjct: 573 AGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G P+L+ T V +S+V+
Sbjct: 628 TGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 671
Score = 175 bits (425), Expect = 2e-42
Identities = 129/438 (29%), Positives = 209/438 (47%), Gaps = 14/438 (3%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGN--TRGRFSITSQNGRG 421
F + + +AE PP T A+DAD ++ L Y + + T + Q
Sbjct: 133 FPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSL 192
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVF 479
+ + + LD ++ + + L ++A+D G T VQ+ IT D N+ AP F + Y +V
Sbjct: 193 SLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVL 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+A GT V+ ++ATD D G N I YS + V F INP G I T L
Sbjct: 253 ENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVV----YAFTINPNNGEIRTKGKL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E Y ++V A D G ++ + + V+DVNDN P + I ED
Sbjct: 309 DFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAI 368
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 IALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVVTA 427
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG+P +T V + + D+ND+ P F T ++ EN+P G I + A D D N
Sbjct: 428 RDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQEN 487
Query: 720 AVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASPPLWN 776
A+V YS ++ + S ++ ++ + LD+E ++++ R + PPL +
Sbjct: 488 ALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 153 bits (370), Expect = 1e-35
Identities = 139/498 (27%), Positives = 214/498 (42%), Gaps = 39/498 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND++P F Y+ +V E A +GT V+ L ATD D G N ++ Y+
Sbjct: 230 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFR------- 282
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P V F I+ +G + T+ LD E+ Y + V+A D+ + +
Sbjct: 283 RP---------VWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKG---NIPM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ T+ V ++D NDN P+ + + ++ + ED + +IA I +D D G+N +
Sbjct: 331 AGHCTLLVEVLDVNDNAPEVTITSLSLPIRED--TQPSAIIALISVSDRDSGSNGQVTCT 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS T + + +
Sbjct: 389 L---TPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
DVNDNAP F + V EN P G I V A DAD NA ++Y++ ++ +
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 M-PGQYEV--ELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ PG ++E P G V + A DAD L YE+ R
Sbjct: 566 LTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ +PLD + L V D G + TA V +++ ++ A
Sbjct: 626 LYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESGQAPQASSRASAG 685
Query: 476 ASVFEDAPIGTTVLVVSA 493
A E A + V ++ A
Sbjct: 686 AVGPEAALVDVNVYLIIA 703
Score = 123 bits (297), Expect = 8e-27
Identities = 99/326 (30%), Positives = 148/326 (45%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN P+F + I E
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKRIIIAESRP 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD---REEGSFVIDPASGVIRTNKALDRESVAT 652
T GA+DAD+G+N + Y LDP D + + + +S + K LDRE +
Sbjct: 148 PETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQE 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
H L A DGG P + TV + I I D+ND+ P F + EN+ GT + ++ A
Sbjct: 208 HSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNAT 267
Query: 713 DPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPD+G N + YS + +F++ G E+ T LD+E +K YE+ + A
Sbjct: 268 DPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG----EIRTKGKLDFEE-KKLYEISVEA 322
Query: 770 ASP---PLWNDVRVEILVTDVNDNAP 792
P+ + + V DVNDNAP
Sbjct: 323 VDKGNIPMAGHCTLLVEVLDVNDNAP 348
>AF152325-1|AAD43719.1| 931|Homo sapiens protocadherin gamma A5
protein.
Length = 931
Score = 235 bits (576), Expect = 1e-60
Identities = 186/610 (30%), Positives = 291/610 (47%), Gaps = 36/610 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + L V +++ + V IID NDN+P
Sbjct: 74 LFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNIL-VENKMKIYG-VEVEIIDINDNFP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
+F ++ V V+E+ + V+ A DADVG NS Y + ++ + FS+D +SG
Sbjct: 132 RFRDEELKVKVNENAAAGTRLVLPF--ARDADVGVNSLRSYQL---SSNLHFSLDVVSGT 186
Query: 208 ------DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
++ L + LD E+ + L++ A DGG P S TT + + + D NDNAP F S
Sbjct: 187 DGQKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+ SV EN+P+G ++ + A D DEG+N +LTY+ +++ + +D G + T
Sbjct: 247 YSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEE--EKISETFQLDSNLGEISTL 304
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E Y + V A DGG A+A + ++ED P
Sbjct: 305 QSLDYEESRFYLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLP 362
Query: 382 GTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GT + + D D E+ + I N + + N L+T + LD ++ Y +
Sbjct: 363 GTVIALFSVHDGDSGENGEIACSIP-RNLPFKLEKSVDNYYHLLT-TRDLDREETSDYNI 420
Query: 440 TVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
T++ D G S + + + + D N+ P F A Y+ SV E+ P G ++ V+A D D
Sbjct: 421 TLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPD 480
Query: 498 VGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G NA++TYSL+ + A IN TG + + D E + L VTA D G
Sbjct: 481 SGDNARVTYSLAEDTFQGAPL--SSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSG 538
Query: 558 VPSLSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADV 610
P LS + + V+D NDN P + L T A G V++V A D D
Sbjct: 539 NPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDS 598
Query: 611 GLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSS 669
G N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+
Sbjct: 599 GQNAWLSYRL-LKASEPGLFAVGLHTGEVRTARALLDRDALKQSLVVAVE-DHGQPPLSA 656
Query: 670 TVIVHIKIED 679
T V + + D
Sbjct: 657 TFTVTVAVAD 666
Score = 218 bits (532), Expect = 3e-55
Identities = 172/609 (28%), Positives = 276/609 (45%), Gaps = 28/609 (4%)
Query: 194 GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYR-LVIRAQDGGSPSRSNTTQLLINIRDVND 252
G TQ+ F+++ SG + +D E++ + L + + ++ + + I D+ND
Sbjct: 70 GRTQL-FALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDIND 128
Query: 253 NAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITID 312
N PRF + V+EN G +V A DAD GVN+ +Y ++ + + T
Sbjct: 129 NFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDG 188
Query: 313 PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYE 372
+ + LDRE + + LL+TA DGGDP S T F P +Y
Sbjct: 189 QKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYS 248
Query: 373 VELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLD 430
V + E+ P GT ++ LTATD DE + +L Y + + + G I+ Q LD
Sbjct: 249 VSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLD 308
Query: 431 FKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLV 490
+++ R Y++ V A D G +A V + + D N+ AP T+S+ ED GT + +
Sbjct: 309 YEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIAL 368
Query: 491 VSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLT 550
S D D G N +I S+ + + D + + T + LDRE S Y +T
Sbjct: 369 FSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYY-------HLLTTRDLDREETSDYNIT 421
Query: 551 VTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADV 610
+T D G P LS + + + V DVNDN P F Q Y+ ++ E+ G S+ V A D D
Sbjct: 422 LTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDS 481
Query: 611 GLNGRIHYELDPKDREEG----SFV-IDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
G N R+ Y L +D +G S+V I+ +GV+ ++ D E + L A D G P
Sbjct: 482 GDNARVTYSL-AEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNP 540
Query: 666 PQSSTVIVHIKIEDINDSPP-----VFESDCLTFY--ISENSPIGTTIGEIRAHDPDEGP 718
P SS V + + + D ND+ P +D T ++ G + ++ A D D G
Sbjct: 541 PLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQ 600
Query: 719 NAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWND 777
NA + Y + + F++ G + LD ++ ++ + + PPL
Sbjct: 601 NAWLSYRLLKASEPGLFAVGLHTGEVRTARAL---LDRDALKQSLVVAVEDHGQPPLSAT 657
Query: 778 VRVEILVTD 786
V + V D
Sbjct: 658 FTVTVAVAD 666
Score = 213 bits (521), Expect = 6e-54
Identities = 152/492 (30%), Positives = 249/492 (50%), Gaps = 18/492 (3%)
Query: 311 IDPRSGWVYTSGQLDRETQ-AKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE A+ L V + + F
Sbjct: 77 LNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFRDE 136
Query: 370 QYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL--ITV 425
+ +V++ E+ GT +V A DAD N L Y+++ ++ +G+ + +
Sbjct: 137 ELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDGQKYPELVL 196
Query: 426 AQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
QPLD ++E + L ++A D G S T +++ + DAN+ AP+F + Y+ SV E+ P
Sbjct: 197 EQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIP 256
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
+GT +L+++ATD D GIN ++TYS +E E ++ + F ++ G I+T + LD E
Sbjct: 257 VGTRLLMLTATDPDEGINGKLTYSFRNE--EEKIS---ETFQLDSNLGEISTLQSLDYEE 311
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
YL+ V A+DGG +L + V ++V DVNDN P T++I ED L GT ++
Sbjct: 312 SRFYLMEVVAQDGG--ALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIALF 369
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGG 663
D D G NG I + + +D ++ T + LDRE + +++ +D G
Sbjct: 370 SVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLL-TTRDLDREETSDYNITLTVMDHG 428
Query: 664 TPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVH 723
TPP S+ + +K+ D+ND+PP F + ++EN+P G +I + AHDPD G NA V
Sbjct: 429 TPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVT 488
Query: 724 YSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPR--KKYELVIRAASPPLWNDVRV 780
YS+ + S SD L + DYE R + + + +PPL ++V +
Sbjct: 489 YSLAEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSL 548
Query: 781 EILVTDVNDNAP 792
+ V D NDN P
Sbjct: 549 SLFVLDQNDNTP 560
Score = 198 bits (483), Expect = 2e-49
Identities = 171/585 (29%), Positives = 263/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND+ P F ++ + V E A++GT ++ A D D+G N+ Y +
Sbjct: 120 EVEIIDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQL------- 172
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ V DG+ L+ LDREK + +L+ A D PV
Sbjct: 173 ---------SSNLHFSLDVVSGTDGQKYPELVLEQPLDREKETVHDLLLTALDGGDPV-- 221
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
LS T I V ++D NDN P F+ Y+VSV E+I V + + ATD D G N +
Sbjct: 222 -LSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTR--LLMLTATDPDEGINGKLT 278
Query: 189 YAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ ++ F +DS G++S +++LDYE+ R Y + + AQDGG+ S ++++
Sbjct: 279 YSFRNEEEKISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGALVAS--AKVVVT 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
++DVNDNAP + S+SE+ G I +D D G N E+ ++ +
Sbjct: 337 VQDVNDNAPEVILTSLTSSISEDCLPGTVIALFSVHDGDSGENGEIACSIPR-------N 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ Y T+ LDRE + Y + +T D G PP S +
Sbjct: 390 LPFKLEKSVDNYYHLLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G + ++TA D D DN R+ Y + +G S S N
Sbjct: 450 PNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINS 509
Query: 420 -RGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ + D++Q R L V+A+DSG S + + + D N+ P ++ P
Sbjct: 510 DTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPT 569
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 570 DGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLK-------ASEPGLFAVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V D G P LS T V ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QSLVVAVEDHGQPPLSATFTVTVAVAD 666
Score = 165 bits (401), Expect = 2e-39
Identities = 135/497 (27%), Positives = 218/497 (43%), Gaps = 38/497 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ VLD ND++P+F +Y SV E GT +L L ATD D G N ++ Y+
Sbjct: 227 HIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFR---- 282
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
N E+ + + F++D G + T SLD E+ Y + V A D +
Sbjct: 283 ---NEEE----------KISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGA--- 326
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L ++A + V + D NDN P+ + T S+ ED VIA D D G N I
Sbjct: 327 --LVASAKVVVTVQDVNDNAPEVILTSLTSSISED--CLPGTVIALFSVHDGDSGENGEI 382
Query: 188 RYAIIGG-NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
+I +++ S+D+ + + LD E+ Y + + D G+P S + + +
Sbjct: 383 ACSIPRNLPFKLEKSVDNYY-HLLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLK 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ DVNDN P F + + SV+EN P G SI V A+D D G NA +TY++ + + G +
Sbjct: 442 VADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E QL VTA+D G+PP S+ +
Sbjct: 502 SSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPE 561
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G VELA PG V + A D D L Y + + G F++
Sbjct: 562 ILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTA 476
G + A+ L + + L V+ D G +A + + A+ + +
Sbjct: 622 HTGE--VRTARALLDRDALKQSLVVAVEDHGQPPLSATFTVTVAVADRIPDILADLGSIK 679
Query: 477 SVFEDAPIGTTVLVVSA 493
+ + + T+ +V A
Sbjct: 680 TPIDPEDLDLTLYLVVA 696
Score = 144 bits (350), Expect = 3e-33
Identities = 97/311 (31%), Positives = 148/311 (47%), Gaps = 18/311 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP++G++ T +DRE + L V + V + VE+ ++D+NDN P
Sbjct: 73 QLFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPR 132
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV-- 638
F+ + + E+A GT + A DADVG+N Y+L F +D SG
Sbjct: 133 FRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLH----FSLDVVSGTDG 188
Query: 639 -----IRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+ + LDRE HDL A+DGG P S T + + + D ND+ P+F +
Sbjct: 189 QKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYS 248
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTM 751
+ EN P+GT + + A DPDEG N + YS + ++ S +F L++ G E+ T+
Sbjct: 249 VSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLG----EISTL 304
Query: 752 VDLDYESPRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
LDYE R V+ L +V + V DVNDNAP + + + +DC P
Sbjct: 305 QSLDYEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGT 364
Query: 812 PFGRVPAYDAD 822
+D D
Sbjct: 365 VIALFSVHDGD 375
Score = 66.5 bits (155), Expect = 1e-09
Identities = 75/289 (25%), Positives = 128/289 (44%), Gaps = 21/289 (7%)
Query: 630 FVIDPASGVIRTNKALDRESV-ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F ++P SG + T +DRE + A L V + + V ++I DIND+ P F
Sbjct: 75 FALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFR 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSD---K 745
+ L ++EN+ GT + A D D G N++ Y + + FSL+ G+D
Sbjct: 135 DEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQL---SSNLHFSLDVVSGTDGQKY 191
Query: 746 AELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
ELV LD E ++L++ A P L + + V D NDNAP+ +
Sbjct: 192 PELVLEQPLDREK-ETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSV- 249
Query: 803 NYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNT 857
+ + PVG + A D D + KL Y + + L+ G ++ L+
Sbjct: 250 SVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLDY 309
Query: 858 NVPKLATMEVSVTDGVNEI-KAMMQLSVRLITE---EMLLNSITVRLND 902
+ MEV DG + A + ++V+ + + E++L S+T +++
Sbjct: 310 EESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISE 358
>AF152309-1|AAD43703.1| 950|Homo sapiens protocadherin alpha 13
protein.
Length = 950
Score = 235 bits (576), Expect = 1e-60
Identities = 175/614 (28%), Positives = 285/614 (46%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVEVKVRDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDS 204
P F E + + E S A+DAD+G NSA+ Y + + Q S++
Sbjct: 131 PIFPESKKRIIIAE--SRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQ 188
Query: 205 LSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
+S +SLV KTLD E+++ + L++ A DGG P + T QLLI I DVNDNAP FY S++
Sbjct: 189 MSS-LSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ +V EN G ++++ A D D+G N ++ Y+ + V TI+P +G + T G
Sbjct: 248 KVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPA-VVYAFTINPNNGEIRTKG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LD E + Y++ V A D G+ P + T + + ED P
Sbjct: 307 KLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPS 366
Query: 383 TPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ ++ +D D + T + + T +N L+ + LD + Y L V
Sbjct: 367 AIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQ 485
Query: 500 INAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD GV
Sbjct: 486 ENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSARDSGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVF------KQQLYTANIMEDAL-VGTSVSQVGATDADVG 611
P L +++ V+D NDN P + +M ++ G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL F + +G I T + LD H L + D G P ++T
Sbjct: 603 YNAWLSYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLLSLVESGQAP 676
Score = 200 bits (489), Expect = 4e-50
Identities = 147/500 (29%), Positives = 229/500 (45%), Gaps = 25/500 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F S + ++E+ P A DAD GVN+ LTY + DY
Sbjct: 121 VKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYF-T 179
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D +++ S + LDRE ++ LL+TA+DGG P + T
Sbjct: 180 LDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGR-FSITSQNGR 420
F Y+V + E+ GT V+ L ATD D+ + Y ++ T
Sbjct: 240 PEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNN 299
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASV 478
G I LDF++++ Y ++V A D G + + + + D N+ AP + +
Sbjct: 300 GEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPI 359
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED + ++S +D D G N Q+T +L+ + + V+ + + ++ +
Sbjct: 360 REDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYY-------SLVLDSA 412
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGC 472
Query: 599 SVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATHD 654
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 473 HIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQ 532
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTIG 707
+ A D G PP S V + + + D ND+ P + +SE P G +
Sbjct: 533 FQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVA 592
Query: 708 EIRAHDPDEGPNAVVHYSIK 727
++RA D D G NA + Y ++
Sbjct: 593 KVRAVDADSGYNAWLSYELQ 612
Score = 197 bits (480), Expect = 5e-49
Identities = 161/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ P+F + + E T A+D DIG N+ + Y ++
Sbjct: 118 HVEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
TL+ +++ S +L+ R +LDRE++ +++L+ A+D P
Sbjct: 178 FTLDAQNSLEQMS---------------SLSLVLRKTLDREEIQEHSLLLTASDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + I+D NDN P+F + Y V+V E + + ++ K+ ATD D G N I
Sbjct: 221 -ELTGTVQLLITILDVNDNAPEFYQSVYKVTVLE--NAFNGTLVIKLNATDPDDGTNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + F+I+ +G++ LD+E+ + Y + + A D G+ + LL
Sbjct: 278 VYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP + + E+ I + D D G N ++T T+T +
Sbjct: 338 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 393 VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHA 512
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF-----EN 471
G + QPLD ++ VSA DSG +Q+ + D N+ AP +
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGS 572
Query: 472 APYTASVFEDAPIGT--TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
A T S +G V V A D+D G NA ++Y L + F +
Sbjct: 573 AGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G P+L+ T V +S+V+
Sbjct: 628 TGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 671
Score = 175 bits (425), Expect = 2e-42
Identities = 129/438 (29%), Positives = 209/438 (47%), Gaps = 14/438 (3%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGN--TRGRFSITSQNGRG 421
F + + +AE PP T A+DAD ++ L Y + + T + Q
Sbjct: 133 FPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSL 192
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVF 479
+ + + LD ++ + + L ++A+D G T VQ+ IT D N+ AP F + Y +V
Sbjct: 193 SLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVL 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+A GT V+ ++ATD D G N I YS + V F INP G I T L
Sbjct: 253 ENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVV----YAFTINPNNGEIRTKGKL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E Y ++V A D G ++ + + V+DVNDN P + I ED
Sbjct: 309 DFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAI 368
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 IALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVVTA 427
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG+P +T V + + D+ND+ P F T ++ EN+P G I + A D D N
Sbjct: 428 RDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQEN 487
Query: 720 AVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASPPLWN 776
A+V YS ++ + S ++ ++ + LD+E ++++ R + PPL +
Sbjct: 488 ALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 153 bits (370), Expect = 1e-35
Identities = 139/498 (27%), Positives = 214/498 (42%), Gaps = 39/498 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND++P F Y+ +V E A +GT V+ L ATD D G N ++ Y+
Sbjct: 230 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFR------- 282
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P V F I+ +G + T+ LD E+ Y + V+A D+ + +
Sbjct: 283 RP---------VWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKG---NIPM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ T+ V ++D NDN P+ + + ++ + ED + +IA I +D D G+N +
Sbjct: 331 AGHCTLLVEVLDVNDNAPEVTITSLSLPIRED--TQPSAIIALISVSDRDSGSNGQVTCT 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS T + + +
Sbjct: 389 L---TPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
DVNDNAP F + V EN P G I V A DAD NA ++Y++ ++ +
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 M-PGQYEV--ELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ PG ++E P G V + A DAD L YE+ R
Sbjct: 566 LTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ +PLD + L V D G + TA V +++ ++ A
Sbjct: 626 LYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESGQAPQASSRASAG 685
Query: 476 ASVFEDAPIGTTVLVVSA 493
A E A + V ++ A
Sbjct: 686 AVGPEAALVDVNVYLIIA 703
Score = 123 bits (297), Expect = 8e-27
Identities = 99/326 (30%), Positives = 148/326 (45%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN P+F + I E
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKRIIIAESRP 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD---REEGSFVIDPASGVIRTNKALDRESVAT 652
T GA+DAD+G+N + Y LDP D + + + +S + K LDRE +
Sbjct: 148 PETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQE 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
H L A DGG P + TV + I I D+ND+ P F + EN+ GT + ++ A
Sbjct: 208 HSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNAT 267
Query: 713 DPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPD+G N + YS + +F++ G E+ T LD+E +K YE+ + A
Sbjct: 268 DPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG----EIRTKGKLDFEE-KKLYEISVEA 322
Query: 770 ASP---PLWNDVRVEILVTDVNDNAP 792
P+ + + V DVNDNAP
Sbjct: 323 VDKGNIPMAGHCTLLVEVLDVNDNAP 348
>AC005609-1|AAC34314.1| 807|Homo sapiens KIAA0345-like 1 protein.
Length = 807
Score = 235 bits (576), Expect = 1e-60
Identities = 175/614 (28%), Positives = 285/614 (46%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVEVKVRDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDS 204
P F E + + E S A+DAD+G NSA+ Y + + Q S++
Sbjct: 131 PIFPESKKRIIIAE--SRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQ 188
Query: 205 LSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
+S +SLV KTLD E+++ + L++ A DGG P + T QLLI I DVNDNAP FY S++
Sbjct: 189 MSS-LSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ +V EN G ++++ A D D+G N ++ Y+ + V TI+P +G + T G
Sbjct: 248 KVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPA-VVYAFTINPNNGEIRTKG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LD E + Y++ V A D G+ P + T + + ED P
Sbjct: 307 KLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPS 366
Query: 383 TPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ ++ +D D + T + + T +N L+ + LD + Y L V
Sbjct: 367 AIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQ 485
Query: 500 INAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD GV
Sbjct: 486 ENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSARDSGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVF------KQQLYTANIMEDAL-VGTSVSQVGATDADVG 611
P L +++ V+D NDN P + +M ++ G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL F + +G I T + LD H L + D G P ++T
Sbjct: 603 YNAWLSYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLLSLVESGQAP 676
Score = 200 bits (489), Expect = 4e-50
Identities = 147/500 (29%), Positives = 229/500 (45%), Gaps = 25/500 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F S + ++E+ P A DAD GVN+ LTY + DY
Sbjct: 121 VKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYF-T 179
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D +++ S + LDRE ++ LL+TA+DGG P + T
Sbjct: 180 LDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGR-FSITSQNGR 420
F Y+V + E+ GT V+ L ATD D+ + Y ++ T
Sbjct: 240 PEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNN 299
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASV 478
G I LDF++++ Y ++V A D G + + + + D N+ AP + +
Sbjct: 300 GEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPI 359
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED + ++S +D D G N Q+T +L+ + + V+ + + ++ +
Sbjct: 360 REDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYY-------SLVLDSA 412
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGC 472
Query: 599 SVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATHD 654
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 473 HIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQ 532
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTIG 707
+ A D G PP S V + + + D ND+ P + +SE P G +
Sbjct: 533 FQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVA 592
Query: 708 EIRAHDPDEGPNAVVHYSIK 727
++RA D D G NA + Y ++
Sbjct: 593 KVRAVDADSGYNAWLSYELQ 612
Score = 197 bits (480), Expect = 5e-49
Identities = 161/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ P+F + + E T A+D DIG N+ + Y ++
Sbjct: 118 HVEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
TL+ +++ S +L+ R +LDRE++ +++L+ A+D P
Sbjct: 178 FTLDAQNSLEQMS---------------SLSLVLRKTLDREEIQEHSLLLTASDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + I+D NDN P+F + Y V+V E + + ++ K+ ATD D G N I
Sbjct: 221 -ELTGTVQLLITILDVNDNAPEFYQSVYKVTVLE--NAFNGTLVIKLNATDPDDGTNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + F+I+ +G++ LD+E+ + Y + + A D G+ + LL
Sbjct: 278 VYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP + + E+ I + D D G N ++T T+T +
Sbjct: 338 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 393 VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHA 512
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF-----EN 471
G + QPLD ++ VSA DSG +Q+ + D N+ AP +
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGS 572
Query: 472 APYTASVFEDAPIGT--TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
A T S +G V V A D+D G NA ++Y L + F +
Sbjct: 573 AGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G P+L+ T V +S+V+
Sbjct: 628 TGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 671
Score = 175 bits (425), Expect = 2e-42
Identities = 129/438 (29%), Positives = 209/438 (47%), Gaps = 14/438 (3%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGN--TRGRFSITSQNGRG 421
F + + +AE PP T A+DAD ++ L Y + + T + Q
Sbjct: 133 FPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSL 192
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVF 479
+ + + LD ++ + + L ++A+D G T VQ+ IT D N+ AP F + Y +V
Sbjct: 193 SLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVL 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+A GT V+ ++ATD D G N I YS + V F INP G I T L
Sbjct: 253 ENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVV----YAFTINPNNGEIRTKGKL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E Y ++V A D G ++ + + V+DVNDN P + I ED
Sbjct: 309 DFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAI 368
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 IALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVVTA 427
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG+P +T V + + D+ND+ P F T ++ EN+P G I + A D D N
Sbjct: 428 RDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQEN 487
Query: 720 AVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASPPLWN 776
A+V YS ++ + S ++ ++ + LD+E ++++ R + PPL +
Sbjct: 488 ALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 153 bits (370), Expect = 1e-35
Identities = 139/498 (27%), Positives = 214/498 (42%), Gaps = 39/498 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND++P F Y+ +V E A +GT V+ L ATD D G N ++ Y+
Sbjct: 230 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFR------- 282
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P V F I+ +G + T+ LD E+ Y + V+A D+ + +
Sbjct: 283 RP---------VWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKG---NIPM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ T+ V ++D NDN P+ + + ++ + ED + +IA I +D D G+N +
Sbjct: 331 AGHCTLLVEVLDVNDNAPEVTITSLSLPIRED--TQPSAIIALISVSDRDSGSNGQVTCT 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS T + + +
Sbjct: 389 L---TPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
DVNDNAP F + V EN P G I V A DAD NA ++Y++ ++ +
Sbjct: 446 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 M-PGQYEV--ELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ PG ++E P G V + A DAD L YE+ R
Sbjct: 566 LTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ +PLD + L V D G + TA V +++ ++ A
Sbjct: 626 LYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESGQAPQASSRASAG 685
Query: 476 ASVFEDAPIGTTVLVVSA 493
A E A + V ++ A
Sbjct: 686 AVGPEAALVDVNVYLIIA 703
Score = 123 bits (297), Expect = 8e-27
Identities = 99/326 (30%), Positives = 148/326 (45%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN P+F + I E
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKRIIIAESRP 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD---REEGSFVIDPASGVIRTNKALDRESVAT 652
T GA+DAD+G+N + Y LDP D + + + +S + K LDRE +
Sbjct: 148 PETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQE 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
H L A DGG P + TV + I I D+ND+ P F + EN+ GT + ++ A
Sbjct: 208 HSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNAT 267
Query: 713 DPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPD+G N + YS + +F++ G E+ T LD+E +K YE+ + A
Sbjct: 268 DPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG----EIRTKGKLDFEE-KKLYEISVEA 322
Query: 770 ASP---PLWNDVRVEILVTDVNDNAP 792
P+ + + V DVNDNAP
Sbjct: 323 VDKGNIPMAGHCTLLVEVLDVNDNAP 348
>AB208924-1|BAD92161.1| 921|Homo sapiens protocadherin alpha 13
isoform 1 precursor variant protein.
Length = 921
Score = 235 bits (576), Expect = 1e-60
Identities = 175/614 (28%), Positives = 285/614 (46%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 90 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVEVKVRDINDNP 147
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDS 204
P F E + + E S A+DAD+G NSA+ Y + + Q S++
Sbjct: 148 PIFPESKKRIIIAE--SRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQ 205
Query: 205 LSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
+S +SLV KTLD E+++ + L++ A DGG P + T QLLI I DVNDNAP FY S++
Sbjct: 206 MSS-LSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVY 264
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ +V EN G ++++ A D D+G N ++ Y+ + V TI+P +G + T G
Sbjct: 265 KVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPA-VVYAFTINPNNGEIRTKG 323
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+LD E + Y++ V A D G+ P + T + + ED P
Sbjct: 324 KLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPS 383
Query: 383 TPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ ++ +D D + T + + T +N L+ + LD + Y L V
Sbjct: 384 AIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVV 442
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 443 TARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQ 502
Query: 500 INAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD GV
Sbjct: 503 ENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSARDSGV 559
Query: 559 PSLSDTTDVEISVVDVNDNEPVF------KQQLYTANIMEDAL-VGTSVSQVGATDADVG 611
P L +++ V+D NDN P + +M ++ G V++V A DAD G
Sbjct: 560 PPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSG 619
Query: 612 LNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL F + +G I T + LD H L + D G P ++T
Sbjct: 620 YNAWLSYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTAT 679
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 680 ATVLLSLVESGQAP 693
Score = 200 bits (489), Expect = 4e-50
Identities = 147/500 (29%), Positives = 229/500 (45%), Gaps = 25/500 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F S + ++E+ P A DAD GVN+ LTY + DY
Sbjct: 138 VKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYF-T 196
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D +++ S + LDRE ++ LL+TA+DGG P + T
Sbjct: 197 LDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNA 256
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGR-FSITSQNGR 420
F Y+V + E+ GT V+ L ATD D+ + Y ++ T
Sbjct: 257 PEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNN 316
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASV 478
G I LDF++++ Y ++V A D G + + + + D N+ AP + +
Sbjct: 317 GEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPI 376
Query: 479 FEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKL 538
ED + ++S +D D G N Q+T +L+ + + V+ + + ++ +
Sbjct: 377 REDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYY-------SLVLDSA 429
Query: 539 LDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGT 598
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 430 LDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGC 489
Query: 599 SVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATHD 654
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 490 HIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQ 549
Query: 655 LKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTIG 707
+ A D G PP S V + + + D ND+ P + +SE P G +
Sbjct: 550 FQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVA 609
Query: 708 EIRAHDPDEGPNAVVHYSIK 727
++RA D D G NA + Y ++
Sbjct: 610 KVRAVDADSGYNAWLSYELQ 629
Score = 197 bits (480), Expect = 5e-49
Identities = 161/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ P+F + + E T A+D DIG N+ + Y ++
Sbjct: 135 HVEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDY 194
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
TL+ +++ S +L+ R +LDRE++ +++L+ A+D P
Sbjct: 195 FTLDAQNSLEQMS---------------SLSLVLRKTLDREEIQEHSLLLTASDGGKP-- 237
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + I+D NDN P+F + Y V+V E + + ++ K+ ATD D G N I
Sbjct: 238 -ELTGTVQLLITILDVNDNAPEFYQSVYKVTVLE--NAFNGTLVIKLNATDPDDGTNGDI 294
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + F+I+ +G++ LD+E+ + Y + + A D G+ + LL
Sbjct: 295 VYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLL 354
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP + + E+ I + D D G N ++T T+T +
Sbjct: 355 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTP-----H 409
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 410 VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNA 469
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 470 PAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHA 529
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF-----EN 471
G + QPLD ++ VSA DSG +Q+ + D N+ AP +
Sbjct: 530 ESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGS 589
Query: 472 APYTASVFEDAPIGT--TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
A T S +G V V A D+D G NA ++Y L + F +
Sbjct: 590 AGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARI-----PFRVGLY 644
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G P+L+ T V +S+V+
Sbjct: 645 TGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 688
Score = 175 bits (425), Expect = 2e-42
Identities = 129/438 (29%), Positives = 209/438 (47%), Gaps = 14/438 (3%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGN--TRGRFSITSQNGRG 421
F + + +AE PP T A+DAD ++ L Y + + T + Q
Sbjct: 150 FPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSL 209
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVF 479
+ + + LD ++ + + L ++A+D G T VQ+ IT D N+ AP F + Y +V
Sbjct: 210 SLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVL 269
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+A GT V+ ++ATD D G N I YS + V F INP G I T L
Sbjct: 270 ENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVV----YAFTINPNNGEIRTKGKL 325
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E Y ++V A D G ++ + + V+DVNDN P + I ED
Sbjct: 326 DFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAI 385
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 386 IALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVVTA 444
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG+P +T V + + D+ND+ P F T ++ EN+P G I + A D D N
Sbjct: 445 RDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQEN 504
Query: 720 AVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASPPLWN 776
A+V YS ++ + S ++ ++ + LD+E ++++ R + PPL +
Sbjct: 505 ALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGS 564
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 565 NVTLQVFVLDENDNAPAL 582
Score = 153 bits (370), Expect = 1e-35
Identities = 139/498 (27%), Positives = 214/498 (42%), Gaps = 39/498 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I +LD ND++P F Y+ +V E A +GT V+ L ATD D G N ++ Y+
Sbjct: 247 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFR------- 299
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P V F I+ +G + T+ LD E+ Y + V+A D+ + +
Sbjct: 300 RP---------VWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKG---NIPM 347
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ T+ V ++D NDN P+ + + ++ + ED + +IA I +D D G+N +
Sbjct: 348 AGHCTLLVEVLDVNDNAPEVTITSLSLPIRED--TQPSAIIALISVSDRDSGSNGQVTCT 405
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS T + + +
Sbjct: 406 L---TPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGV 462
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
DVNDNAP F + V EN P G I V A DAD NA ++Y++ ++ +
Sbjct: 463 ADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALS 522
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 523 SYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPAL 582
Query: 367 M-PGQYEV--ELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ PG ++E P G V + A DAD L YE+ R
Sbjct: 583 LTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVG 642
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ +PLD + L V D G + TA V +++ ++ A
Sbjct: 643 LYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESGQAPQASSRASAG 702
Query: 476 ASVFEDAPIGTTVLVVSA 493
A E A + V ++ A
Sbjct: 703 AVGPEAALVDVNVYLIIA 720
Score = 123 bits (297), Expect = 8e-27
Identities = 99/326 (30%), Positives = 148/326 (45%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 51 SVPEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 104
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V VE+ V D+NDN P+F + I E
Sbjct: 105 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKRIIIAESRP 164
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD---REEGSFVIDPASGVIRTNKALDRESVAT 652
T GA+DAD+G+N + Y LDP D + + + +S + K LDRE +
Sbjct: 165 PETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQE 224
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
H L A DGG P + TV + I I D+ND+ P F + EN+ GT + ++ A
Sbjct: 225 HSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNAT 284
Query: 713 DPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPD+G N + YS + +F++ G E+ T LD+E +K YE+ + A
Sbjct: 285 DPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG----EIRTKGKLDFEE-KKLYEISVEA 339
Query: 770 ASP---PLWNDVRVEILVTDVNDNAP 792
P+ + + V DVNDNAP
Sbjct: 340 VDKGNIPMAGHCTLLVEVLDVNDNAP 365
>BC113609-1|AAI13610.1| 798|Homo sapiens protocadherin alpha 4
protein.
Length = 798
Score = 235 bits (575), Expect = 2e-60
Identities = 175/615 (28%), Positives = 283/615 (46%), Gaps = 31/615 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+ ++ ++G L + +DRE++ R + + + + DR + V + D NDN P
Sbjct: 74 LLEVNLQNGILFVNSRIDREELCRRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDNPP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI-----D 203
F +S+ E + + A+DAD+G N+ + Y + + FS+ D
Sbjct: 132 VFPATQKNLSIAESRPLDSRFPLEG--ASDADIGENALLTYRL---SPNEYFSLEKPPDD 186
Query: 204 SLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
L + L+ K+LD E+ LV+ A DGG P + T QLLI + D NDNAP F ++
Sbjct: 187 ELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTI 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + ENVP G ++++ A D DEG+N ++ Y+ ++ D + NV IDP +G +
Sbjct: 247 YKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSN-DISPNVKSKFHIDPITGQIIVK 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G +D E Y+++V D G P S + + ED P
Sbjct: 306 GYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPL 365
Query: 382 GTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ +D D N L + + T +N L+ + LD + Y L
Sbjct: 366 GTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADA 484
Query: 499 GINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
NA ++YSL + A++ + ++ ++G + + LD E + VTARD G
Sbjct: 485 QENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVTARDAG 541
Query: 558 VPSLSDTTDVEISVVDVNDNEPVF--KQQLYTANIMEDAL-----VGTSVSQVGATDADV 610
VP L +++ V+D NDN P + T + + + VG V++V A DAD
Sbjct: 542 VPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADS 601
Query: 611 GLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + YEL P F + +G I T +ALD H L + D G P ++
Sbjct: 602 GYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTA 661
Query: 670 TVIVHIKIEDINDSP 684
T V + + + +P
Sbjct: 662 TATVLVSLVESGQAP 676
Score = 226 bits (553), Expect = 8e-58
Identities = 165/548 (30%), Positives = 256/548 (46%), Gaps = 30/548 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F + S++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL 180
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
P + + LDRE + L++TATDGG P + T
Sbjct: 181 EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP 240
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQNG 419
F Y+V L E+ P GT V+ L A+D DE + + Y + N + +F I G
Sbjct: 241 AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG 300
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTAS 477
+ I V +DF++ + Y + V D G S V + + D N+ P E +
Sbjct: 301 Q--IIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ EDAP+GT + ++S +D D+G+N +T SL+S + + V+ + ++ +
Sbjct: 359 IREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYY-------SLVLDS 411
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 412 ALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 471
Query: 598 TSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATH 653
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 472 CHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELL 531
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTI 706
+ A D G PP S V + + + D ND+ P + +SE P +G +
Sbjct: 532 QFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVV 591
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYEL 765
++RA D D G NA + Y ++ G + + R G E+ T LD ++PR + +
Sbjct: 592 AKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLV 649
Query: 766 VIRAASPP 773
+++ P
Sbjct: 650 LVKDHGEP 657
Score = 204 bits (499), Expect = 3e-51
Identities = 174/610 (28%), Positives = 270/610 (44%), Gaps = 46/610 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q S+ E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYR------ 171
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + D + G L+ R SLDRE+ +++ ATD P
Sbjct: 172 --LSPNE-----YFSLEKPPDDELVKGLG--LILRKSLDREEAPEIFLVLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D NDN P F Y V + E+ V + ++ K+ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDANDNAPAFDRTIYKVRLLEN--VPNGTLVIKLNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ I N + +F ID ++G + + +D+E+ +SY +++ D G S +++
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVI 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + D NDN P + E+ P+G I + D D GVN +T ++T
Sbjct: 338 VEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV---P 394
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
L T V S LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 395 FKLVSTFKNYYSLVLDSA-LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAE 513
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF--ENAPYT 475
G + QPLD ++ V+A D+G +Q+ + D N+ AP A T
Sbjct: 514 SGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGT 573
Query: 476 A-SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
+V E P +G V V A D+D G NA ++Y L + F + T
Sbjct: 574 GGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVGLYT 628
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 629 GEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVG 688
Query: 591 MEDALVGTSV 600
+ ALV +V
Sbjct: 689 PDAALVDVNV 698
Score = 186 bits (453), Expect = 1e-45
Identities = 137/442 (30%), Positives = 218/442 (49%), Gaps = 22/442 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQ------ 417
F Q + +AE P + A+DAD E+ L Y ++ FS+
Sbjct: 133 FPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEY---FSLEKPPDDELV 189
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYT 475
G GLI + + LD ++ L ++ATD G T VQ+ IT DAN+ AP F+ Y
Sbjct: 190 KGLGLI-LRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYK 248
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
+ E+ P GT V+ ++A+D D G+N I YS S++IS + +F I+P TG I
Sbjct: 249 VRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKS----KFHIDPITGQIIV 304
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+D E Y + V D G LS V + V D NDN P + + + I EDA
Sbjct: 305 KGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAP 364
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDL 655
+GT ++ + +D D+G+NG + L + ++ + ALDRESV+ ++L
Sbjct: 365 LGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 424 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDAD 483
Query: 716 EGPNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASP 772
NA+V YS ++ + S ++ ++ + LD+E ++++ R A P
Sbjct: 484 AQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVP 543
Query: 773 PLWNDVRVEILVTDVNDNAPVM 794
PL ++V +++ V D NDNAP +
Sbjct: 544 PLGSNVTLQVFVLDENDNAPAL 565
Score = 61.3 bits (142), Expect = 5e-08
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 13/212 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V +++ DIND+PPVF + I+E+ P+ +
Sbjct: 93 EELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G NA++ Y + + FSLE + + L+ LD E + +
Sbjct: 153 PLEGASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIF 209
Query: 764 ELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
LV+ A P L V++ I V D NDNAP
Sbjct: 210 -LVLTATDGGKPELTGTVQLLITVLDANDNAP 240
>BC112102-1|AAI12103.1| 798|Homo sapiens protocadherin alpha 4,
isoform 2 precursor protein.
Length = 798
Score = 235 bits (575), Expect = 2e-60
Identities = 175/615 (28%), Positives = 283/615 (46%), Gaps = 31/615 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+ ++ ++G L + +DRE++ R + + + + DR + V + D NDN P
Sbjct: 74 LLEVNLQNGILFVNSRIDREELCRRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDNPP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI-----D 203
F +S+ E + + A+DAD+G N+ + Y + + FS+ D
Sbjct: 132 VFPATQKNLSIAESRPLDSRFPLEG--ASDADIGENALLTYRL---SPNEYFSLEKPPDD 186
Query: 204 SLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
L + L+ K+LD E+ LV+ A DGG P + T QLLI + D NDNAP F ++
Sbjct: 187 ELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTI 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + ENVP G ++++ A D DEG+N ++ Y+ ++ D + NV IDP +G +
Sbjct: 247 YKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSN-DISPNVKSKFHIDPITGQIIVK 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G +D E Y+++V D G P S + + ED P
Sbjct: 306 GYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPL 365
Query: 382 GTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ +D D N L + + T +N L+ + LD + Y L
Sbjct: 366 GTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADA 484
Query: 499 GINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
NA ++YSL + A++ + ++ ++G + + LD E + VTARD G
Sbjct: 485 QENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVTARDAG 541
Query: 558 VPSLSDTTDVEISVVDVNDNEPVF--KQQLYTANIMEDAL-----VGTSVSQVGATDADV 610
VP L +++ V+D NDN P + T + + + VG V++V A DAD
Sbjct: 542 VPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADS 601
Query: 611 GLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + YEL P F + +G I T +ALD H L + D G P ++
Sbjct: 602 GYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTA 661
Query: 670 TVIVHIKIEDINDSP 684
T V + + + +P
Sbjct: 662 TATVLVSLVESGQAP 676
Score = 226 bits (553), Expect = 8e-58
Identities = 165/548 (30%), Positives = 256/548 (46%), Gaps = 30/548 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F + S++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL 180
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
P + + LDRE + L++TATDGG P + T
Sbjct: 181 EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP 240
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQNG 419
F Y+V L E+ P GT V+ L A+D DE + + Y + N + +F I G
Sbjct: 241 AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG 300
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTAS 477
+ I V +DF++ + Y + V D G S V + + D N+ P E +
Sbjct: 301 Q--IIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ EDAP+GT + ++S +D D+G+N +T SL+S + + V+ + ++ +
Sbjct: 359 IREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYY-------SLVLDS 411
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 412 ALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 471
Query: 598 TSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATH 653
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 472 CHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELL 531
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTI 706
+ A D G PP S V + + + D ND+ P + +SE P +G +
Sbjct: 532 QFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVV 591
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYEL 765
++RA D D G NA + Y ++ G + + R G E+ T LD ++PR + +
Sbjct: 592 AKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLV 649
Query: 766 VIRAASPP 773
+++ P
Sbjct: 650 LVKDHGEP 657
Score = 204 bits (499), Expect = 3e-51
Identities = 174/610 (28%), Positives = 270/610 (44%), Gaps = 46/610 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q S+ E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYR------ 171
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + D + G L+ R SLDRE+ +++ ATD P
Sbjct: 172 --LSPNE-----YFSLEKPPDDELVKGLG--LILRKSLDREEAPEIFLVLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D NDN P F Y V + E+ V + ++ K+ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDANDNAPAFDRTIYKVRLLEN--VPNGTLVIKLNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ I N + +F ID ++G + + +D+E+ +SY +++ D G S +++
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVI 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + D NDN P + E+ P+G I + D D GVN +T ++T
Sbjct: 338 VEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV---P 394
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
L T V S LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 395 FKLVSTFKNYYSLVLDSA-LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAE 513
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF--ENAPYT 475
G + QPLD ++ V+A D+G +Q+ + D N+ AP A T
Sbjct: 514 SGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGT 573
Query: 476 A-SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
+V E P +G V V A D+D G NA ++Y L + F + T
Sbjct: 574 GGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVGLYT 628
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 629 GEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVG 688
Query: 591 MEDALVGTSV 600
+ ALV +V
Sbjct: 689 PDAALVDVNV 698
Score = 186 bits (453), Expect = 1e-45
Identities = 137/442 (30%), Positives = 218/442 (49%), Gaps = 22/442 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQ------ 417
F Q + +AE P + A+DAD E+ L Y ++ FS+
Sbjct: 133 FPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEY---FSLEKPPDDELV 189
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYT 475
G GLI + + LD ++ L ++ATD G T VQ+ IT DAN+ AP F+ Y
Sbjct: 190 KGLGLI-LRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYK 248
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
+ E+ P GT V+ ++A+D D G+N I YS S++IS + +F I+P TG I
Sbjct: 249 VRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKS----KFHIDPITGQIIV 304
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+D E Y + V D G LS V + V D NDN P + + + I EDA
Sbjct: 305 KGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAP 364
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDL 655
+GT ++ + +D D+G+NG + L + ++ + ALDRESV+ ++L
Sbjct: 365 LGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 424 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDAD 483
Query: 716 EGPNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASP 772
NA+V YS ++ + S ++ ++ + LD+E ++++ R A P
Sbjct: 484 AQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVP 543
Query: 773 PLWNDVRVEILVTDVNDNAPVM 794
PL ++V +++ V D NDNAP +
Sbjct: 544 PLGSNVTLQVFVLDENDNAPAL 565
Score = 61.3 bits (142), Expect = 5e-08
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 13/212 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V +++ DIND+PPVF + I+E+ P+ +
Sbjct: 93 EELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G NA++ Y + + FSLE + + L+ LD E + +
Sbjct: 153 PLEGASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIF 209
Query: 764 ELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
LV+ A P L V++ I V D NDNAP
Sbjct: 210 -LVLTATDGGKPELTGTVQLLITVLDANDNAP 240
>AF152482-1|AAD43743.1| 798|Homo sapiens protocadherin alpha 4
short form protein protein.
Length = 798
Score = 235 bits (575), Expect = 2e-60
Identities = 175/615 (28%), Positives = 283/615 (46%), Gaps = 31/615 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+ ++ ++G L + +DRE++ R + + + + DR + V + D NDN P
Sbjct: 74 LLEVNLQNGILFVNSRIDREELCRRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDNPP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI-----D 203
F +S+ E + + A+DAD+G N+ + Y + + FS+ D
Sbjct: 132 VFPATQKNLSIAESRPLDSRFPLEG--ASDADIGENALLTYRL---SPNEYFSLEKPPDD 186
Query: 204 SLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
L + L+ K+LD E+ LV+ A DGG P + T QLLI + D NDNAP F ++
Sbjct: 187 ELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTI 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + ENVP G ++++ A D DEG+N ++ Y+ ++ D + NV IDP +G +
Sbjct: 247 YKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSN-DISPNVKSKFHIDPITGQIIVK 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G +D E Y+++V D G P S + + ED P
Sbjct: 306 GYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPL 365
Query: 382 GTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ +D D N L + + T +N L+ + LD + Y L
Sbjct: 366 GTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADA 484
Query: 499 GINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
NA ++YSL + A++ + ++ ++G + + LD E + VTARD G
Sbjct: 485 QENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVTARDAG 541
Query: 558 VPSLSDTTDVEISVVDVNDNEPVF--KQQLYTANIMEDAL-----VGTSVSQVGATDADV 610
VP L +++ V+D NDN P + T + + + VG V++V A DAD
Sbjct: 542 VPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADS 601
Query: 611 GLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + YEL P F + +G I T +ALD H L + D G P ++
Sbjct: 602 GYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTA 661
Query: 670 TVIVHIKIEDINDSP 684
T V + + + +P
Sbjct: 662 TATVLVSLVESGQAP 676
Score = 226 bits (553), Expect = 8e-58
Identities = 165/548 (30%), Positives = 256/548 (46%), Gaps = 30/548 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F + S++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL 180
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
P + + LDRE + L++TATDGG P + T
Sbjct: 181 EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP 240
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQNG 419
F Y+V L E+ P GT V+ L A+D DE + + Y + N + +F I G
Sbjct: 241 AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG 300
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTAS 477
+ I V +DF++ + Y + V D G S V + + D N+ P E +
Sbjct: 301 Q--IIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ EDAP+GT + ++S +D D+G+N +T SL+S + + V+ + ++ +
Sbjct: 359 IREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYY-------SLVLDS 411
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 412 ALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 471
Query: 598 TSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATH 653
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 472 CHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELL 531
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTI 706
+ A D G PP S V + + + D ND+ P + +SE P +G +
Sbjct: 532 QFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVV 591
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYEL 765
++RA D D G NA + Y ++ G + + R G E+ T LD ++PR + +
Sbjct: 592 AKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLV 649
Query: 766 VIRAASPP 773
+++ P
Sbjct: 650 LVKDHGEP 657
Score = 204 bits (499), Expect = 3e-51
Identities = 174/610 (28%), Positives = 270/610 (44%), Gaps = 46/610 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q S+ E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYR------ 171
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + D + G L+ R SLDRE+ +++ ATD P
Sbjct: 172 --LSPNE-----YFSLEKPPDDELVKGLG--LILRKSLDREEAPEIFLVLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D NDN P F Y V + E+ V + ++ K+ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDANDNAPAFDRTIYKVRLLEN--VPNGTLVIKLNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ I N + +F ID ++G + + +D+E+ +SY +++ D G S +++
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVI 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + D NDN P + E+ P+G I + D D GVN +T ++T
Sbjct: 338 VEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV---P 394
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
L T V S LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 395 FKLVSTFKNYYSLVLDSA-LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAE 513
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF--ENAPYT 475
G + QPLD ++ V+A D+G +Q+ + D N+ AP A T
Sbjct: 514 SGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGT 573
Query: 476 A-SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
+V E P +G V V A D+D G NA ++Y L + F + T
Sbjct: 574 GGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVGLYT 628
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 629 GEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVG 688
Query: 591 MEDALVGTSV 600
+ ALV +V
Sbjct: 689 PDAALVDVNV 698
Score = 186 bits (453), Expect = 1e-45
Identities = 137/442 (30%), Positives = 218/442 (49%), Gaps = 22/442 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQ------ 417
F Q + +AE P + A+DAD E+ L Y ++ FS+
Sbjct: 133 FPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEY---FSLEKPPDDELV 189
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYT 475
G GLI + + LD ++ L ++ATD G T VQ+ IT DAN+ AP F+ Y
Sbjct: 190 KGLGLI-LRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYK 248
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
+ E+ P GT V+ ++A+D D G+N I YS S++IS + +F I+P TG I
Sbjct: 249 VRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKS----KFHIDPITGQIIV 304
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+D E Y + V D G LS V + V D NDN P + + + I EDA
Sbjct: 305 KGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAP 364
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDL 655
+GT ++ + +D D+G+NG + L + ++ + ALDRESV+ ++L
Sbjct: 365 LGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 424 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDAD 483
Query: 716 EGPNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASP 772
NA+V YS ++ + S ++ ++ + LD+E ++++ R A P
Sbjct: 484 AQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVP 543
Query: 773 PLWNDVRVEILVTDVNDNAPVM 794
PL ++V +++ V D NDNAP +
Sbjct: 544 PLGSNVTLQVFVLDENDNAPAL 565
Score = 61.3 bits (142), Expect = 5e-08
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 13/212 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V +++ DIND+PPVF + I+E+ P+ +
Sbjct: 93 EELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G NA++ Y + + FSLE + + L+ LD E + +
Sbjct: 153 PLEGASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIF 209
Query: 764 ELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
LV+ A P L V++ I V D NDNAP
Sbjct: 210 -LVLTATDGGKPELTGTVQLLITVLDANDNAP 240
>AF152312-1|AAD43706.1| 947|Homo sapiens protocadherin alpha 4
protein.
Length = 947
Score = 235 bits (575), Expect = 2e-60
Identities = 175/615 (28%), Positives = 283/615 (46%), Gaps = 31/615 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+ ++ ++G L + +DRE++ R + + + + DR + V + D NDN P
Sbjct: 74 LLEVNLQNGILFVNSRIDREELCRRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDNPP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI-----D 203
F +S+ E + + A+DAD+G N+ + Y + + FS+ D
Sbjct: 132 VFPATQKNLSIAESRPLDSRFPLEG--ASDADIGENALLTYRL---SPNEYFSLEKPPDD 186
Query: 204 SLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
L + L+ K+LD E+ LV+ A DGG P + T QLLI + D NDNAP F ++
Sbjct: 187 ELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTI 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + ENVP G ++++ A D DEG+N ++ Y+ ++ D + NV IDP +G +
Sbjct: 247 YKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSN-DISPNVKSKFHIDPITGQIIVK 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G +D E Y+++V D G P S + + ED P
Sbjct: 306 GYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPL 365
Query: 382 GTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ +D D N L + + T +N L+ + LD + Y L
Sbjct: 366 GTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADA 484
Query: 499 GINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
NA ++YSL + A++ + ++ ++G + + LD E + VTARD G
Sbjct: 485 QENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVTARDAG 541
Query: 558 VPSLSDTTDVEISVVDVNDNEPVF--KQQLYTANIMEDAL-----VGTSVSQVGATDADV 610
VP L +++ V+D NDN P + T + + + VG V++V A DAD
Sbjct: 542 VPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADS 601
Query: 611 GLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + YEL P F + +G I T +ALD H L + D G P ++
Sbjct: 602 GYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTA 661
Query: 670 TVIVHIKIEDINDSP 684
T V + + + +P
Sbjct: 662 TATVLVSLVESGQAP 676
Score = 226 bits (553), Expect = 8e-58
Identities = 165/548 (30%), Positives = 256/548 (46%), Gaps = 30/548 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F + S++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL 180
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
P + + LDRE + L++TATDGG P + T
Sbjct: 181 EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP 240
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQNG 419
F Y+V L E+ P GT V+ L A+D DE + + Y + N + +F I G
Sbjct: 241 AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG 300
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTAS 477
+ I V +DF++ + Y + V D G S V + + D N+ P E +
Sbjct: 301 Q--IIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ EDAP+GT + ++S +D D+G+N +T SL+S + + V+ + ++ +
Sbjct: 359 IREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYY-------SLVLDS 411
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 412 ALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 471
Query: 598 TSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATH 653
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 472 CHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELL 531
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTI 706
+ A D G PP S V + + + D ND+ P + +SE P +G +
Sbjct: 532 QFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVV 591
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYEL 765
++RA D D G NA + Y ++ G + + R G E+ T LD ++PR + +
Sbjct: 592 AKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLV 649
Query: 766 VIRAASPP 773
+++ P
Sbjct: 650 LVKDHGEP 657
Score = 204 bits (499), Expect = 3e-51
Identities = 174/610 (28%), Positives = 270/610 (44%), Gaps = 46/610 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q S+ E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYR------ 171
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + D + G L+ R SLDRE+ +++ ATD P
Sbjct: 172 --LSPNE-----YFSLEKPPDDELVKGLG--LILRKSLDREEAPEIFLVLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D NDN P F Y V + E+ V + ++ K+ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDANDNAPAFDRTIYKVRLLEN--VPNGTLVIKLNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ I N + +F ID ++G + + +D+E+ +SY +++ D G S +++
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVI 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + D NDN P + E+ P+G I + D D GVN +T ++T
Sbjct: 338 VEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV---P 394
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
L T V S LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 395 FKLVSTFKNYYSLVLDSA-LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAE 513
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF--ENAPYT 475
G + QPLD ++ V+A D+G +Q+ + D N+ AP A T
Sbjct: 514 SGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGT 573
Query: 476 A-SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
+V E P +G V V A D+D G NA ++Y L + F + T
Sbjct: 574 GGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVGLYT 628
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 629 GEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVG 688
Query: 591 MEDALVGTSV 600
+ ALV +V
Sbjct: 689 PDAALVDVNV 698
Score = 186 bits (453), Expect = 1e-45
Identities = 137/442 (30%), Positives = 218/442 (49%), Gaps = 22/442 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQ------ 417
F Q + +AE P + A+DAD E+ L Y ++ FS+
Sbjct: 133 FPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEY---FSLEKPPDDELV 189
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYT 475
G GLI + + LD ++ L ++ATD G T VQ+ IT DAN+ AP F+ Y
Sbjct: 190 KGLGLI-LRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYK 248
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
+ E+ P GT V+ ++A+D D G+N I YS S++IS + +F I+P TG I
Sbjct: 249 VRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKS----KFHIDPITGQIIV 304
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+D E Y + V D G LS V + V D NDN P + + + I EDA
Sbjct: 305 KGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAP 364
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDL 655
+GT ++ + +D D+G+NG + L + ++ + ALDRESV+ ++L
Sbjct: 365 LGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 424 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDAD 483
Query: 716 EGPNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASP 772
NA+V YS ++ + S ++ ++ + LD+E ++++ R A P
Sbjct: 484 AQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVP 543
Query: 773 PLWNDVRVEILVTDVNDNAPVM 794
PL ++V +++ V D NDNAP +
Sbjct: 544 PLGSNVTLQVFVLDENDNAPAL 565
Score = 61.3 bits (142), Expect = 5e-08
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 13/212 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V +++ DIND+PPVF + I+E+ P+ +
Sbjct: 93 EELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G NA++ Y + + FSLE + + L+ LD E + +
Sbjct: 153 PLEGASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIF 209
Query: 764 ELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
LV+ A P L V++ I V D NDNAP
Sbjct: 210 -LVLTATDGGKPELTGTVQLLITVLDANDNAP 240
>AC005609-10|AAC34322.1| 798|Homo sapiens KIAA0345-like 10 protein.
Length = 798
Score = 235 bits (575), Expect = 2e-60
Identities = 175/615 (28%), Positives = 283/615 (46%), Gaps = 31/615 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+ ++ ++G L + +DRE++ R + + + + DR + V + D NDN P
Sbjct: 74 LLEVNLQNGILFVNSRIDREELCRRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDNPP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI-----D 203
F +S+ E + + A+DAD+G N+ + Y + + FS+ D
Sbjct: 132 VFPATQKNLSIAESRPLDSRFPLEG--ASDADIGENALLTYRL---SPNEYFSLEKPPDD 186
Query: 204 SLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
L + L+ K+LD E+ LV+ A DGG P + T QLLI + D NDNAP F ++
Sbjct: 187 ELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTI 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + ENVP G ++++ A D DEG+N ++ Y+ ++ D + NV IDP +G +
Sbjct: 247 YKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSN-DISPNVKSKFHIDPITGQIIVK 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G +D E Y+++V D G P S + + ED P
Sbjct: 306 GYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPL 365
Query: 382 GTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ +D D N L + + T +N L+ + LD + Y L
Sbjct: 366 GTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADA 484
Query: 499 GINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
NA ++YSL + A++ + ++ ++G + + LD E + VTARD G
Sbjct: 485 QENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVTARDAG 541
Query: 558 VPSLSDTTDVEISVVDVNDNEPVF--KQQLYTANIMEDAL-----VGTSVSQVGATDADV 610
VP L +++ V+D NDN P + T + + + VG V++V A DAD
Sbjct: 542 VPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADS 601
Query: 611 GLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + YEL P F + +G I T +ALD H L + D G P ++
Sbjct: 602 GYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTA 661
Query: 670 TVIVHIKIEDINDSP 684
T V + + + +P
Sbjct: 662 TATVLVSLVESGQAP 676
Score = 226 bits (553), Expect = 8e-58
Identities = 165/548 (30%), Positives = 256/548 (46%), Gaps = 30/548 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F + S++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL 180
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
P + + LDRE + L++TATDGG P + T
Sbjct: 181 EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP 240
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQNG 419
F Y+V L E+ P GT V+ L A+D DE + + Y + N + +F I G
Sbjct: 241 AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG 300
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTAS 477
+ I V +DF++ + Y + V D G S V + + D N+ P E +
Sbjct: 301 Q--IIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ EDAP+GT + ++S +D D+G+N +T SL+S + + V+ + ++ +
Sbjct: 359 IREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYY-------SLVLDS 411
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 412 ALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 471
Query: 598 TSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATH 653
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 472 CHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELL 531
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTI 706
+ A D G PP S V + + + D ND+ P + +SE P +G +
Sbjct: 532 QFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVV 591
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYEL 765
++RA D D G NA + Y ++ G + + R G E+ T LD ++PR + +
Sbjct: 592 AKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLV 649
Query: 766 VIRAASPP 773
+++ P
Sbjct: 650 LVKDHGEP 657
Score = 204 bits (499), Expect = 3e-51
Identities = 174/610 (28%), Positives = 270/610 (44%), Gaps = 46/610 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q S+ E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYR------ 171
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + D + G L+ R SLDRE+ +++ ATD P
Sbjct: 172 --LSPNE-----YFSLEKPPDDELVKGLG--LILRKSLDREEAPEIFLVLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D NDN P F Y V + E+ V + ++ K+ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDANDNAPAFDRTIYKVRLLEN--VPNGTLVIKLNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ I N + +F ID ++G + + +D+E+ +SY +++ D G S +++
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVI 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + D NDN P + E+ P+G I + D D GVN +T ++T
Sbjct: 338 VEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV---P 394
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
L T V S LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 395 FKLVSTFKNYYSLVLDSA-LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAE 513
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF--ENAPYT 475
G + QPLD ++ V+A D+G +Q+ + D N+ AP A T
Sbjct: 514 SGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGT 573
Query: 476 A-SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
+V E P +G V V A D+D G NA ++Y L + F + T
Sbjct: 574 GGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVGLYT 628
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 629 GEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVG 688
Query: 591 MEDALVGTSV 600
+ ALV +V
Sbjct: 689 PDAALVDVNV 698
Score = 186 bits (453), Expect = 1e-45
Identities = 137/442 (30%), Positives = 218/442 (49%), Gaps = 22/442 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQ------ 417
F Q + +AE P + A+DAD E+ L Y ++ FS+
Sbjct: 133 FPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEY---FSLEKPPDDELV 189
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYT 475
G GLI + + LD ++ L ++ATD G T VQ+ IT DAN+ AP F+ Y
Sbjct: 190 KGLGLI-LRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYK 248
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
+ E+ P GT V+ ++A+D D G+N I YS S++IS + +F I+P TG I
Sbjct: 249 VRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKS----KFHIDPITGQIIV 304
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+D E Y + V D G LS V + V D NDN P + + + I EDA
Sbjct: 305 KGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAP 364
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDL 655
+GT ++ + +D D+G+NG + L + ++ + ALDRESV+ ++L
Sbjct: 365 LGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 424 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDAD 483
Query: 716 EGPNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASP 772
NA+V YS ++ + S ++ ++ + LD+E ++++ R A P
Sbjct: 484 AQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVP 543
Query: 773 PLWNDVRVEILVTDVNDNAPVM 794
PL ++V +++ V D NDNAP +
Sbjct: 544 PLGSNVTLQVFVLDENDNAPAL 565
Score = 61.3 bits (142), Expect = 5e-08
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 13/212 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 34 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDR 92
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V +++ DIND+PPVF + I+E+ P+ +
Sbjct: 93 EELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRF 152
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G NA++ Y + + FSLE + + L+ LD E + +
Sbjct: 153 PLEGASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIF 209
Query: 764 ELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
LV+ A P L V++ I V D NDNAP
Sbjct: 210 -LVLTATDGGKPELTGTVQLLITVLDANDNAP 240
>AB208925-1|BAD92162.1| 921|Homo sapiens protocadherin alpha 4
isoform 1 precursor variant protein.
Length = 921
Score = 235 bits (575), Expect = 2e-60
Identities = 175/615 (28%), Positives = 283/615 (46%), Gaps = 31/615 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+ ++ ++G L + +DRE++ R + + + + DR + V + D NDN P
Sbjct: 94 LLEVNLQNGILFVNSRIDREELCRRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDNPP 151
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSI-----D 203
F +S+ E + + A+DAD+G N+ + Y + + FS+ D
Sbjct: 152 VFPATQKNLSIAESRPLDSRFPLEG--ASDADIGENALLTYRL---SPNEYFSLEKPPDD 206
Query: 204 SLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
L + L+ K+LD E+ LV+ A DGG P + T QLLI + D NDNAP F ++
Sbjct: 207 ELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTI 266
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + ENVP G ++++ A D DEG+N ++ Y+ ++ D + NV IDP +G +
Sbjct: 267 YKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSN-DISPNVKSKFHIDPITGQIIVK 325
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G +D E Y+++V D G P S + + ED P
Sbjct: 326 GYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPL 385
Query: 382 GTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ +D D N L + + T +N L+ + LD + Y L
Sbjct: 386 GTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYELV 444
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 445 VTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADA 504
Query: 499 GINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
NA ++YSL + A++ + ++ ++G + + LD E + VTARD G
Sbjct: 505 QENALVSYSLVERRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVTARDAG 561
Query: 558 VPSLSDTTDVEISVVDVNDNEPVF--KQQLYTANIMEDAL-----VGTSVSQVGATDADV 610
VP L +++ V+D NDN P + T + + + VG V++V A DAD
Sbjct: 562 VPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADS 621
Query: 611 GLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSS 669
G N + YEL P F + +G I T +ALD H L + D G P ++
Sbjct: 622 GYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTA 681
Query: 670 TVIVHIKIEDINDSP 684
T V + + + +P
Sbjct: 682 TATVLVSLVESGQAP 696
Score = 226 bits (553), Expect = 8e-58
Identities = 165/548 (30%), Positives = 256/548 (46%), Gaps = 30/548 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ +RD+NDN P F + S++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 141 VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL 200
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
P + + LDRE + L++TATDGG P + T
Sbjct: 201 EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP 260
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQNG 419
F Y+V L E+ P GT V+ L A+D DE + + Y + N + +F I G
Sbjct: 261 AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG 320
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTAS 477
+ I V +DF++ + Y + V D G S V + + D N+ P E +
Sbjct: 321 Q--IIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 378
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ EDAP+GT + ++S +D D+G+N +T SL+S + + V+ + ++ +
Sbjct: 379 IREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYY-------SLVLDS 431
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 432 ALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 491
Query: 598 TSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATH 653
+ V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 492 CHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELL 551
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF---ESDCLTFYISENSP----IGTTI 706
+ A D G PP S V + + + D ND+ P + +SE P +G +
Sbjct: 552 QFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVV 611
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYEL 765
++RA D D G NA + Y ++ G + + R G E+ T LD ++PR + +
Sbjct: 612 AKVRAVDADSGYNAWLSYELQPG--TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLV 669
Query: 766 VIRAASPP 773
+++ P
Sbjct: 670 LVKDHGEP 677
Score = 204 bits (499), Expect = 3e-51
Identities = 174/610 (28%), Positives = 270/610 (44%), Gaps = 46/610 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q S+ E + A+D DIG+NA + Y
Sbjct: 138 HVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYR------ 191
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + D + G L+ R SLDRE+ +++ ATD P
Sbjct: 192 --LSPNE-----YFSLEKPPDDELVKGLG--LILRKSLDREEAPEIFLVLTATDGGKP-- 240
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D NDN P F Y V + E+ V + ++ K+ A+D D G N I
Sbjct: 241 -ELTGTVQLLITVLDANDNAPAFDRTIYKVRLLEN--VPNGTLVIKLNASDLDEGLNGDI 297
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ I N + +F ID ++G + + +D+E+ +SY +++ D G S +++
Sbjct: 298 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVI 357
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + D NDN P + E+ P+G I + D D GVN +T ++T
Sbjct: 358 VEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV---P 414
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
L T V S LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 415 FKLVSTFKNYYSLVLDSA-LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 473
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 474 AFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAE 533
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF--ENAPYT 475
G + QPLD ++ V+A D+G +Q+ + D N+ AP A T
Sbjct: 534 SGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGT 593
Query: 476 A-SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
+V E P +G V V A D+D G NA ++Y L + F + T
Sbjct: 594 GGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIP-----FRVGLYT 648
Query: 531 GAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI 590
G I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 649 GEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVG 708
Query: 591 MEDALVGTSV 600
+ ALV +V
Sbjct: 709 PDAALVDVNV 718
Score = 186 bits (453), Expect = 1e-45
Identities = 137/442 (30%), Positives = 218/442 (49%), Gaps = 22/442 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQ------ 417
F Q + +AE P + A+DAD E+ L Y ++ FS+
Sbjct: 153 FPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEY---FSLEKPPDDELV 209
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYT 475
G GLI + + LD ++ L ++ATD G T VQ+ IT DAN+ AP F+ Y
Sbjct: 210 KGLGLI-LRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYK 268
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
+ E+ P GT V+ ++A+D D G+N I YS S++IS + +F I+P TG I
Sbjct: 269 VRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKS----KFHIDPITGQIIV 324
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+D E Y + V D G LS V + V D NDN P + + + I EDA
Sbjct: 325 KGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAP 384
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDL 655
+GT ++ + +D D+G+NG + L + ++ + ALDRESV+ ++L
Sbjct: 385 LGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 443
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 444 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDAD 503
Query: 716 EGPNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYES-PRKKYELVIR-AASP 772
NA+V YS ++ + S ++ ++ + LD+E ++++ R A P
Sbjct: 504 AQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVP 563
Query: 773 PLWNDVRVEILVTDVNDNAPVM 794
PL ++V +++ V D NDNAP +
Sbjct: 564 PLGSNVTLQVFVLDENDNAPAL 585
Score = 61.3 bits (142), Expect = 5e-08
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 13/212 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
++ E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 54 SVSEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDR 112
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V +++ DIND+PPVF + I+E+ P+ +
Sbjct: 113 EELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRF 172
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAE---LVTMVDLDYESPRKKY 763
A D D G NA++ Y + + FSLE + + L+ LD E + +
Sbjct: 173 PLEGASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIF 229
Query: 764 ELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
LV+ A P L V++ I V D NDNAP
Sbjct: 230 -LVLTATDGGKPELTGTVQLLITVLDANDNAP 260
>BC036674-1|AAH36674.1| 950|Homo sapiens PCDHA6 protein protein.
Length = 950
Score = 233 bits (569), Expect = 9e-60
Identities = 172/616 (27%), Positives = 285/616 (46%), Gaps = 29/616 (4%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 72 EDLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI-----IGGNTQMQFS 201
P F + V + E S + V A+DADVG+NS + Y + G + ++ S
Sbjct: 130 PPLFPVEEQRVLIYE--SRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKIN-S 186
Query: 202 IDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
D+ + L K+LD E+ ++ L + A DGG P + T QLL+ + DVNDNAP F S
Sbjct: 187 DDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + EN G +++R+ A D DEG N ++Y+ +D +ID +G +
Sbjct: 247 YEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVID-HFSIDRNTGEIVIR 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G LD E + Y++L+ ATD G PP + T + + ED
Sbjct: 306 GNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF 365
Query: 382 GTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GT + ++ D D + +++ +T + + T +N L+ + LD + Y L
Sbjct: 366 GTVIALISVNDLDSGANGQVNCSLT-PHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 440 TVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
V+A D G S TA + + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 424 VVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483
Query: 498 VGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD
Sbjct: 484 AQENALVSYSLVERRVGERALSSY---ISVHAESGKVYALQPLDHEELELLQFQVSARDA 540
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDAD 609
GVP L +++ V+D NDN P T + + + G V++V A DAD
Sbjct: 541 GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDAD 600
Query: 610 VGLNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQS 668
G N + YEL P F + +G I T + LD H L + D G P +
Sbjct: 601 SGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT 660
Query: 669 STVIVHIKIEDINDSP 684
+T V + + + +P
Sbjct: 661 ATATVLVSLVESGQAP 676
Score = 217 bits (530), Expect = 5e-55
Identities = 162/550 (29%), Positives = 249/550 (45%), Gaps = 34/550 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQ-AYDADEGVNAELTYTMTDKDYTG 303
+ +RD+NDN P F + + E+ + S+ ++ A DAD G N+ LTY ++ +Y G
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYES-RLPDSVFPLEGASDADVGSNSILTYKLSSSEYFG 179
Query: 304 NVDLPITIDPRSG-WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+D+ I D + LDRE + L +TATDGG P + T
Sbjct: 180 -LDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDN 238
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYE---ITGGNTRGRFSITSQ 417
F +YEV + E+ GT V+ L A+D DE + + Y + FSI
Sbjct: 239 APTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRN 298
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYT 475
G I + LDF+QE Y + + ATD G + V + I D N+ P +
Sbjct: 299 TGE--IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLS 356
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
V EDA GT + ++S D D G N Q+ SL+ + + V+ + ++
Sbjct: 357 LPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYY-------SLVL 409
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+ LDRE++S Y L VTARDGG PSL T + + V D+NDN P F Q YT + E+
Sbjct: 410 DSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNP 469
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVA 651
G + V A DAD N + Y L + +R S++ + SG + + LD E +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELE 529
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGT 704
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQ 589
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKY 763
+ ++RA D D G NA + Y ++ S F R G E+ T LD +SPR +
Sbjct: 590 VVAKVRAVDADSGYNAWLSYELQPPASSARFPF--RVGLYTGEISTTRVLDEADSPRHRL 647
Query: 764 ELVIRAASPP 773
++++ P
Sbjct: 648 LVLVKDHGEP 657
Score = 189 bits (460), Expect = 1e-46
Identities = 127/415 (30%), Positives = 214/415 (51%), Gaps = 16/415 (3%)
Query: 390 ATDAD--EDNRLHYEITGGNTRGR-FSITSQNGRGL-ITVAQPLDFKQERRYVLTVSATD 445
A+DAD ++ L Y+++ G I S + + + + + + LD ++ + L ++ATD
Sbjct: 157 ASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATD 216
Query: 446 SGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T VQ+ +T D N+ AP FE + Y +FE+A GTTV+ ++A+D D G N
Sbjct: 217 GGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGA 276
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
I+YS +S ++ + H F I+ TG I LD E + Y + + A D G P ++
Sbjct: 277 ISYSFNSLVAAMVIDH----FSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAG 332
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
V + ++D NDN P + + EDA GT ++ + D D G NG+++ L P
Sbjct: 333 HCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPH 392
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
+ ++ + ALDRESV+ ++L A DGG+P +T + +++ D+ND+
Sbjct: 393 VPFKLVSTFKNYYSLV-LDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDN 451
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI---KGGDDSNSFSLETR 740
P F T ++ EN+P G I + A D D NA+V YS+ + G+ + S +
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVH 511
Query: 741 QGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWNDVRVEILVTDVNDNAPVM 794
S K + +D + E ++++ R A PPL ++V +++ V D NDNAP +
Sbjct: 512 AESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Score = 182 bits (443), Expect = 2e-44
Identities = 149/498 (29%), Positives = 221/498 (44%), Gaps = 39/498 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND++P FE +YE + E A +GTTV+ L A+D+D G N + Y+ + A
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVA--- 286
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V D F ID +G ++ R +LD E+ Y +L+ ATD+ P +
Sbjct: 287 -------------AMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHP---PM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ T+ V I+D NDN P+ + + ++ V ED VIA I D D GAN + +
Sbjct: 331 AGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF--GTVIALISVNDLDSGANGQVNCS 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS T L + +
Sbjct: 389 L---TPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
D+NDNAP F + V EN P G I V A DAD NA ++Y++ ++ +
Sbjct: 446 ADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 MP---GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G ++E P G V + A DAD L YE+ + RF
Sbjct: 566 LAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ + LD R+ L V D G + TA V +++ ++ A
Sbjct: 626 LYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVG 685
Query: 476 ASVFEDAPIGTTVLVVSA 493
A+ E A + V ++ A
Sbjct: 686 AAGPEAALVDVNVYLIIA 703
Score = 60.5 bits (140), Expect = 9e-08
Identities = 57/226 (25%), Positives = 106/226 (46%), Gaps = 16/226 (7%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + + + KDRE+ ++ +G++ N +D
Sbjct: 34 SVPEEAKHGTFVGRI-AQDLGLELAELVPRLFRMASKDRED-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V +++ DIND+PP+F + I E+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSV 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMV---DLDYE-SPRK 761
A D D G N+++ Y + S F L+ + SD + + ++ LD E +P
Sbjct: 152 FPLEGASDADVGSNSILTYKLSS---SEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAH 208
Query: 762 KYELVIR-AASPPLWNDVRVEILVTDVNDNAPVMK--DFQI-IFNN 803
L P L V++ + V DVNDNAP + ++++ IF N
Sbjct: 209 NLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFEN 254
>AF152484-1|AAD43745.1| 803|Homo sapiens protocadherin alpha 6
short form protein protein.
Length = 803
Score = 233 bits (569), Expect = 9e-60
Identities = 172/616 (27%), Positives = 285/616 (46%), Gaps = 29/616 (4%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 72 EDLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI-----IGGNTQMQFS 201
P F + V + E S + V A+DADVG+NS + Y + G + ++ S
Sbjct: 130 PPLFPVEEQRVLIYE--SRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKIN-S 186
Query: 202 IDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
D+ + L K+LD E+ ++ L + A DGG P + T QLL+ + DVNDNAP F S
Sbjct: 187 DDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + EN G +++R+ A D DEG N ++Y+ +D +ID +G +
Sbjct: 247 YEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVID-HFSIDRNTGEIVIR 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G LD E + Y++L+ ATD G PP + T + + ED
Sbjct: 306 GNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF 365
Query: 382 GTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GT + ++ D D + +++ +T + + T +N L+ + LD + Y L
Sbjct: 366 GTVIALISVNDLDSGANGQVNCSLT-PHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 440 TVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
V+A D G S TA + + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 424 VVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483
Query: 498 VGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD
Sbjct: 484 AQENALVSYSLVERRVGERALSSY---ISVHAESGKVYALQPLDHEELELLQFQVSARDA 540
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDAD 609
GVP L +++ V+D NDN P T + + + G V++V A DAD
Sbjct: 541 GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDAD 600
Query: 610 VGLNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQS 668
G N + YEL P F + +G I T + LD H L + D G P +
Sbjct: 601 SGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT 660
Query: 669 STVIVHIKIEDINDSP 684
+T V + + + +P
Sbjct: 661 ATATVLVSLVESGQAP 676
Score = 217 bits (530), Expect = 5e-55
Identities = 162/550 (29%), Positives = 249/550 (45%), Gaps = 34/550 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQ-AYDADEGVNAELTYTMTDKDYTG 303
+ +RD+NDN P F + + E+ + S+ ++ A DAD G N+ LTY ++ +Y G
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYES-RLPDSVFPLEGASDADVGSNSILTYKLSSSEYFG 179
Query: 304 NVDLPITIDPRSG-WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+D+ I D + LDRE + L +TATDGG P + T
Sbjct: 180 -LDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDN 238
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYE---ITGGNTRGRFSITSQ 417
F +YEV + E+ GT V+ L A+D DE + + Y + FSI
Sbjct: 239 APTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRN 298
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYT 475
G I + LDF+QE Y + + ATD G + V + I D N+ P +
Sbjct: 299 TGE--IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLS 356
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
V EDA GT + ++S D D G N Q+ SL+ + + V+ + ++
Sbjct: 357 LPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYY-------SLVL 409
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+ LDRE++S Y L VTARDGG PSL T + + V D+NDN P F Q YT + E+
Sbjct: 410 DSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNP 469
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVA 651
G + V A DAD N + Y L + +R S++ + SG + + LD E +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELE 529
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGT 704
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQ 589
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKY 763
+ ++RA D D G NA + Y ++ S F R G E+ T LD +SPR +
Sbjct: 590 VVAKVRAVDADSGYNAWLSYELQPPASSARFPF--RVGLYTGEISTTRVLDEADSPRHRL 647
Query: 764 ELVIRAASPP 773
++++ P
Sbjct: 648 LVLVKDHGEP 657
Score = 189 bits (460), Expect = 1e-46
Identities = 127/415 (30%), Positives = 214/415 (51%), Gaps = 16/415 (3%)
Query: 390 ATDAD--EDNRLHYEITGGNTRGR-FSITSQNGRGL-ITVAQPLDFKQERRYVLTVSATD 445
A+DAD ++ L Y+++ G I S + + + + + + LD ++ + L ++ATD
Sbjct: 157 ASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATD 216
Query: 446 SGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T VQ+ +T D N+ AP FE + Y +FE+A GTTV+ ++A+D D G N
Sbjct: 217 GGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGA 276
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
I+YS +S ++ + H F I+ TG I LD E + Y + + A D G P ++
Sbjct: 277 ISYSFNSLVAAMVIDH----FSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAG 332
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
V + ++D NDN P + + EDA GT ++ + D D G NG+++ L P
Sbjct: 333 HCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPH 392
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
+ ++ + ALDRESV+ ++L A DGG+P +T + +++ D+ND+
Sbjct: 393 VPFKLVSTFKNYYSLV-LDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDN 451
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI---KGGDDSNSFSLETR 740
P F T ++ EN+P G I + A D D NA+V YS+ + G+ + S +
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVH 511
Query: 741 QGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWNDVRVEILVTDVNDNAPVM 794
S K + +D + E ++++ R A PPL ++V +++ V D NDNAP +
Sbjct: 512 AESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Score = 182 bits (443), Expect = 2e-44
Identities = 149/498 (29%), Positives = 221/498 (44%), Gaps = 39/498 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND++P FE +YE + E A +GTTV+ L A+D+D G N + Y+ + A
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVA--- 286
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V D F ID +G ++ R +LD E+ Y +L+ ATD+ P +
Sbjct: 287 -------------AMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHP---PM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ T+ V I+D NDN P+ + + ++ V ED VIA I D D GAN + +
Sbjct: 331 AGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF--GTVIALISVNDLDSGANGQVNCS 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS T L + +
Sbjct: 389 L---TPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
D+NDNAP F + V EN P G I V A DAD NA ++Y++ ++ +
Sbjct: 446 ADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 MP---GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G ++E P G V + A DAD L YE+ + RF
Sbjct: 566 LAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ + LD R+ L V D G + TA V +++ ++ A
Sbjct: 626 LYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVG 685
Query: 476 ASVFEDAPIGTTVLVVSA 493
A+ E A + V ++ A
Sbjct: 686 AAGPEAALVDVNVYLIIA 703
Score = 60.5 bits (140), Expect = 9e-08
Identities = 57/226 (25%), Positives = 106/226 (46%), Gaps = 16/226 (7%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + + + KDRE+ ++ +G++ N +D
Sbjct: 34 SVPEEAKHGTFVGRI-AQDLGLELAELVPRLFRMASKDRED-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V +++ DIND+PP+F + I E+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSV 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMV---DLDYE-SPRK 761
A D D G N+++ Y + S F L+ + SD + + ++ LD E +P
Sbjct: 152 FPLEGASDADVGSNSILTYKLSS---SEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAH 208
Query: 762 KYELVIR-AASPPLWNDVRVEILVTDVNDNAPVMK--DFQI-IFNN 803
L P L V++ + V DVNDNAP + ++++ IF N
Sbjct: 209 NLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFEN 254
>AF152314-1|AAD43708.1| 950|Homo sapiens protocadherin alpha 6
protein.
Length = 950
Score = 233 bits (569), Expect = 9e-60
Identities = 172/616 (27%), Positives = 285/616 (46%), Gaps = 29/616 (4%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 72 EDLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI-----IGGNTQMQFS 201
P F + V + E S + V A+DADVG+NS + Y + G + ++ S
Sbjct: 130 PPLFPVEEQRVLIYE--SRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKIN-S 186
Query: 202 IDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
D+ + L K+LD E+ ++ L + A DGG P + T QLL+ + DVNDNAP F S
Sbjct: 187 DDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + EN G +++R+ A D DEG N ++Y+ +D +ID +G +
Sbjct: 247 YEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVID-HFSIDRNTGEIVIR 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G LD E + Y++L+ ATD G PP + T + + ED
Sbjct: 306 GNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF 365
Query: 382 GTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GT + ++ D D + +++ +T + + T +N L+ + LD + Y L
Sbjct: 366 GTVIALISVNDLDSGANGQVNCSLT-PHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 440 TVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
V+A D G S TA + + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 424 VVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483
Query: 498 VGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD
Sbjct: 484 AQENALVSYSLVERRVGERALSSY---ISVHAESGKVYALQPLDHEELELLQFQVSARDA 540
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDAD 609
GVP L +++ V+D NDN P T + + + G V++V A DAD
Sbjct: 541 GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDAD 600
Query: 610 VGLNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQS 668
G N + YEL P F + +G I T + LD H L + D G P +
Sbjct: 601 SGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT 660
Query: 669 STVIVHIKIEDINDSP 684
+T V + + + +P
Sbjct: 661 ATATVLVSLVESGQAP 676
Score = 217 bits (530), Expect = 5e-55
Identities = 162/550 (29%), Positives = 249/550 (45%), Gaps = 34/550 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQ-AYDADEGVNAELTYTMTDKDYTG 303
+ +RD+NDN P F + + E+ + S+ ++ A DAD G N+ LTY ++ +Y G
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYES-RLPDSVFPLEGASDADVGSNSILTYKLSSSEYFG 179
Query: 304 NVDLPITIDPRSG-WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+D+ I D + LDRE + L +TATDGG P + T
Sbjct: 180 -LDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDN 238
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYE---ITGGNTRGRFSITSQ 417
F +YEV + E+ GT V+ L A+D DE + + Y + FSI
Sbjct: 239 APTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRN 298
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYT 475
G I + LDF+QE Y + + ATD G + V + I D N+ P +
Sbjct: 299 TGE--IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLS 356
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
V EDA GT + ++S D D G N Q+ SL+ + + V+ + ++
Sbjct: 357 LPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYY-------SLVL 409
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+ LDRE++S Y L VTARDGG PSL T + + V D+NDN P F Q YT + E+
Sbjct: 410 DSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNP 469
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVA 651
G + V A DAD N + Y L + +R S++ + SG + + LD E +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELE 529
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGT 704
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQ 589
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKY 763
+ ++RA D D G NA + Y ++ S F R G E+ T LD +SPR +
Sbjct: 590 VVAKVRAVDADSGYNAWLSYELQPPASSARFPF--RVGLYTGEISTTRVLDEADSPRHRL 647
Query: 764 ELVIRAASPP 773
++++ P
Sbjct: 648 LVLVKDHGEP 657
Score = 189 bits (460), Expect = 1e-46
Identities = 127/415 (30%), Positives = 214/415 (51%), Gaps = 16/415 (3%)
Query: 390 ATDAD--EDNRLHYEITGGNTRGR-FSITSQNGRGL-ITVAQPLDFKQERRYVLTVSATD 445
A+DAD ++ L Y+++ G I S + + + + + + LD ++ + L ++ATD
Sbjct: 157 ASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATD 216
Query: 446 SGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T VQ+ +T D N+ AP FE + Y +FE+A GTTV+ ++A+D D G N
Sbjct: 217 GGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGA 276
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
I+YS +S ++ + H F I+ TG I LD E + Y + + A D G P ++
Sbjct: 277 ISYSFNSLVAAMVIDH----FSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAG 332
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
V + ++D NDN P + + EDA GT ++ + D D G NG+++ L P
Sbjct: 333 HCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPH 392
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
+ ++ + ALDRESV+ ++L A DGG+P +T + +++ D+ND+
Sbjct: 393 VPFKLVSTFKNYYSLV-LDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDN 451
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI---KGGDDSNSFSLETR 740
P F T ++ EN+P G I + A D D NA+V YS+ + G+ + S +
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVH 511
Query: 741 QGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWNDVRVEILVTDVNDNAPVM 794
S K + +D + E ++++ R A PPL ++V +++ V D NDNAP +
Sbjct: 512 AESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Score = 182 bits (443), Expect = 2e-44
Identities = 149/498 (29%), Positives = 221/498 (44%), Gaps = 39/498 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND++P FE +YE + E A +GTTV+ L A+D+D G N + Y+ + A
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVA--- 286
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V D F ID +G ++ R +LD E+ Y +L+ ATD+ P +
Sbjct: 287 -------------AMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHP---PM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ T+ V I+D NDN P+ + + ++ V ED VIA I D D GAN + +
Sbjct: 331 AGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF--GTVIALISVNDLDSGANGQVNCS 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS T L + +
Sbjct: 389 L---TPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
D+NDNAP F + V EN P G I V A DAD NA ++Y++ ++ +
Sbjct: 446 ADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 MP---GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G ++E P G V + A DAD L YE+ + RF
Sbjct: 566 LAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ + LD R+ L V D G + TA V +++ ++ A
Sbjct: 626 LYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVG 685
Query: 476 ASVFEDAPIGTTVLVVSA 493
A+ E A + V ++ A
Sbjct: 686 AAGPEAALVDVNVYLIIA 703
Score = 60.5 bits (140), Expect = 9e-08
Identities = 57/226 (25%), Positives = 106/226 (46%), Gaps = 16/226 (7%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + + + KDRE+ ++ +G++ N +D
Sbjct: 34 SVPEEAKHGTFVGRI-AQDLGLELAELVPRLFRMASKDRED-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V +++ DIND+PP+F + I E+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSV 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMV---DLDYE-SPRK 761
A D D G N+++ Y + S F L+ + SD + + ++ LD E +P
Sbjct: 152 FPLEGASDADVGSNSILTYKLSS---SEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAH 208
Query: 762 KYELVIR-AASPPLWNDVRVEILVTDVNDNAPVMK--DFQI-IFNN 803
L P L V++ + V DVNDNAP + ++++ IF N
Sbjct: 209 NLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFEN 254
>AC005609-8|AAC34320.1| 803|Homo sapiens KIAA0345-like 8 protein.
Length = 803
Score = 233 bits (569), Expect = 9e-60
Identities = 172/616 (27%), Positives = 285/616 (46%), Gaps = 29/616 (4%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 72 EDLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVRDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI-----IGGNTQMQFS 201
P F + V + E S + V A+DADVG+NS + Y + G + ++ S
Sbjct: 130 PPLFPVEEQRVLIYE--SRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKIN-S 186
Query: 202 IDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
D+ + L K+LD E+ ++ L + A DGG P + T QLL+ + DVNDNAP F S
Sbjct: 187 DDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + EN G +++R+ A D DEG N ++Y+ +D +ID +G +
Sbjct: 247 YEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVID-HFSIDRNTGEIVIR 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G LD E + Y++L+ ATD G PP + T + + ED
Sbjct: 306 GNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF 365
Query: 382 GTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVL 439
GT + ++ D D + +++ +T + + T +N L+ + LD + Y L
Sbjct: 366 GTVIALISVNDLDSGANGQVNCSLT-PHVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 440 TVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
V+A D G S TA + + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 424 VVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483
Query: 498 VGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD
Sbjct: 484 AQENALVSYSLVERRVGERALSSY---ISVHAESGKVYALQPLDHEELELLQFQVSARDA 540
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDAD 609
GVP L +++ V+D NDN P T + + + G V++V A DAD
Sbjct: 541 GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDAD 600
Query: 610 VGLNGRIHYELD-PKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQS 668
G N + YEL P F + +G I T + LD H L + D G P +
Sbjct: 601 SGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT 660
Query: 669 STVIVHIKIEDINDSP 684
+T V + + + +P
Sbjct: 661 ATATVLVSLVESGQAP 676
Score = 217 bits (530), Expect = 5e-55
Identities = 162/550 (29%), Positives = 249/550 (45%), Gaps = 34/550 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQ-AYDADEGVNAELTYTMTDKDYTG 303
+ +RD+NDN P F + + E+ + S+ ++ A DAD G N+ LTY ++ +Y G
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYES-RLPDSVFPLEGASDADVGSNSILTYKLSSSEYFG 179
Query: 304 NVDLPITIDPRSG-WVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXX 362
+D+ I D + LDRE + L +TATDGG P + T
Sbjct: 180 -LDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDN 238
Query: 363 XXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYE---ITGGNTRGRFSITSQ 417
F +YEV + E+ GT V+ L A+D DE + + Y + FSI
Sbjct: 239 APTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRN 298
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYT 475
G I + LDF+QE Y + + ATD G + V + I D N+ P +
Sbjct: 299 TGE--IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLS 356
Query: 476 ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITT 535
V EDA GT + ++S D D G N Q+ SL+ + + V+ + ++
Sbjct: 357 LPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYY-------SLVL 409
Query: 536 NKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+ LDRE++S Y L VTARDGG PSL T + + V D+NDN P F Q YT + E+
Sbjct: 410 DSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNP 469
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVA 651
G + V A DAD N + Y L + +R S++ + SG + + LD E +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELE 529
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGT 704
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQ 589
Query: 705 TIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKY 763
+ ++RA D D G NA + Y ++ S F R G E+ T LD +SPR +
Sbjct: 590 VVAKVRAVDADSGYNAWLSYELQPPASSARFPF--RVGLYTGEISTTRVLDEADSPRHRL 647
Query: 764 ELVIRAASPP 773
++++ P
Sbjct: 648 LVLVKDHGEP 657
Score = 189 bits (460), Expect = 1e-46
Identities = 127/415 (30%), Positives = 214/415 (51%), Gaps = 16/415 (3%)
Query: 390 ATDAD--EDNRLHYEITGGNTRGR-FSITSQNGRGL-ITVAQPLDFKQERRYVLTVSATD 445
A+DAD ++ L Y+++ G I S + + + + + + LD ++ + L ++ATD
Sbjct: 157 ASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATD 216
Query: 446 SGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T VQ+ +T D N+ AP FE + Y +FE+A GTTV+ ++A+D D G N
Sbjct: 217 GGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGA 276
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
I+YS +S ++ + H F I+ TG I LD E + Y + + A D G P ++
Sbjct: 277 ISYSFNSLVAAMVIDH----FSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAG 332
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
V + ++D NDN P + + EDA GT ++ + D D G NG+++ L P
Sbjct: 333 HCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPH 392
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
+ ++ + ALDRESV+ ++L A DGG+P +T + +++ D+ND+
Sbjct: 393 VPFKLVSTFKNYYSLV-LDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDN 451
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI---KGGDDSNSFSLETR 740
P F T ++ EN+P G I + A D D NA+V YS+ + G+ + S +
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVH 511
Query: 741 QGSDKAELVTMVDLDYESPRKKYELVIR-AASPPLWNDVRVEILVTDVNDNAPVM 794
S K + +D + E ++++ R A PPL ++V +++ V D NDNAP +
Sbjct: 512 AESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Score = 182 bits (443), Expect = 2e-44
Identities = 149/498 (29%), Positives = 221/498 (44%), Gaps = 39/498 (7%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ VLD ND++P FE +YE + E A +GTTV+ L A+D+D G N + Y+ + A
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVA--- 286
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V D F ID +G ++ R +LD E+ Y +L+ ATD+ P +
Sbjct: 287 -------------AMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHP---PM 330
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ T+ V I+D NDN P+ + + ++ V ED VIA I D D GAN + +
Sbjct: 331 AGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF--GTVIALISVNDLDSGANGQVNCS 388
Query: 191 IIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ + F + + SLV LD E V +Y LV+ A+DGGSPS T L + +
Sbjct: 389 L---TPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEV 445
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-VD 306
D+NDNAP F + V EN P G I V A DAD NA ++Y++ ++ +
Sbjct: 446 ADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALS 505
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
I++ SG VY LD E Q V+A D G PP + T
Sbjct: 506 SYISVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL 565
Query: 367 MP---GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G ++E P G V + A DAD L YE+ + RF
Sbjct: 566 LAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFRVG 625
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT 475
G I+ + LD R+ L V D G + TA V +++ ++ A
Sbjct: 626 LYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVG 685
Query: 476 ASVFEDAPIGTTVLVVSA 493
A+ E A + V ++ A
Sbjct: 686 AAGPEAALVDVNVYLIIA 703
Score = 60.5 bits (140), Expect = 9e-08
Identities = 57/226 (25%), Positives = 106/226 (46%), Gaps = 16/226 (7%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + + + KDRE+ ++ +G++ N +D
Sbjct: 34 SVPEEAKHGTFVGRI-AQDLGLELAELVPRLFRMASKDRED-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V +++ DIND+PP+F + I E+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSV 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMV---DLDYE-SPRK 761
A D D G N+++ Y + S F L+ + SD + + ++ LD E +P
Sbjct: 152 FPLEGASDADVGSNSILTYKLSS---SEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAH 208
Query: 762 KYELVIR-AASPPLWNDVRVEILVTDVNDNAPVMK--DFQI-IFNN 803
L P L V++ + V DVNDNAP + ++++ IF N
Sbjct: 209 NLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFEN 254
>AF152486-1|AAD43747.1| 814|Homo sapiens protocadherin alpha 8
short form protein protein.
Length = 814
Score = 231 bits (566), Expect = 2e-59
Identities = 172/614 (28%), Positives = 277/614 (45%), Gaps = 25/614 (4%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ + ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 72 RDLLEVSLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDVNDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
P F K + V E + D+ + A+DADVGANS + Y + + ++S +
Sbjct: 130 PPVFRVKDQKLFVSES-RMPDSRFPLE-GASDADVGANSVLTYRL-SSHDYFMLDVNSKN 186
Query: 207 GDVSLV-----KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
+ LV K+LD E ++ L + A DGG P + T QLL+ + DVNDNAP F S
Sbjct: 187 DENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + EN G +++++ A D DEG N ++Y+ T +D +ID +G +
Sbjct: 247 YEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVID-HFSIDRNTGEIVIR 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G LD E + Y++L+ ATD G PP + T + + ED
Sbjct: 306 GNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF 365
Query: 382 GTPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ D D + + + T +N L+ + LD ++ Y L
Sbjct: 366 GTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRERVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA + + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADA 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 485 QENALVSYSLVERRVGERSL--SSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLY-----TANIMEDALVGTS--VSQVGATDADVG 611
P L +++ V+D NDN P + A+ + VG V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P F + +G I T + LD H L + D G P ++T
Sbjct: 603 YNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 211 bits (515), Expect = 3e-53
Identities = 163/549 (29%), Positives = 242/549 (44%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++DVNDN P F + VSE+ A DAD G N+ LTY ++ DY
Sbjct: 121 VEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYF-M 179
Query: 305 VDLPITIDPRS-GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ D + LDRE + L +TATDGG P + T
Sbjct: 180 LDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSITSQN 418
F +YEV + E+ GT V+ L A+D DE + + Y FSI
Sbjct: 240 PTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNT 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G I + LDF+QE Y + + ATD G + V + I D N+ P +
Sbjct: 300 GE--IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA GT + ++S D D G N Q+T SL + + V+ + ++ +
Sbjct: 358 PVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE +S Y L VTARDGG PSL T + + V DVNDN P F Q YT + E+
Sbjct: 411 SALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S++ + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P + + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ ++S + R G E+ T LD +SPR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPA--ASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 200 bits (488), Expect = 6e-50
Identities = 167/612 (27%), Positives = 265/612 (43%), Gaps = 50/612 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF ++ + V E + A+D D+G N+ + Y +
Sbjct: 118 HVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+ + + L+ R SLDRE + + + ATD P
Sbjct: 178 FMLDVNSKND---------------ENKLVELVLRKSLDREDAPAHHLFLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + V ++D NDN P F + Y V + E + + + K+ A+D D GAN AI
Sbjct: 221 -ELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE--NADNGTTVIKLNASDPDEGANGAI 277
Query: 188 RY---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y +++ FSID +G++ + LD+EQ Y+++I A D G P + +L
Sbjct: 278 SYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ I D NDN P + V E+ G I + D D G N ++T ++ +
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE + Y+L+VTA DGG P ATA+
Sbjct: 393 VPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGRFSITS----Q 417
F +Y V + E+ PPG + T++A DAD ++N L Y + G S++S
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRV-GERSLSSYISVH 511
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------ 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 512 TESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVG 571
Query: 470 -ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+ V G V V A D+D G NA ++Y L S+ + F +
Sbjct: 572 GTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRI-----PFRVGL 626
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
TG I+T ++LD + L V +D G P+L+ T V +S+V+ +Q
Sbjct: 627 YTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGV 686
Query: 589 NIMEDALVGTSV 600
E ALV +V
Sbjct: 687 LGPEAALVDVNV 698
Score = 184 bits (449), Expect = 3e-45
Identities = 118/378 (31%), Positives = 192/378 (50%), Gaps = 12/378 (3%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + LD + + L ++ATD G T VQ+ +T D N+ AP FE + Y +FE
Sbjct: 194 LVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+A GTTV+ ++A+D D G N I+YS +S + + H F I+ TG I LD
Sbjct: 254 NADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDH----FSIDRNTGEIVIRGNLD 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A D G P ++ V + ++D NDN P + + EDA GT +
Sbjct: 310 FEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + D D G NG++ L P + ++ + ALDRE V+ ++L A
Sbjct: 370 ALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRERVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T + +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
Query: 721 VVHYSI---KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWN 776
+V YS+ + G+ S S + S K + +D + E ++++ R A PPL +
Sbjct: 489 LVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 151 bits (366), Expect = 4e-35
Identities = 132/450 (29%), Positives = 202/450 (44%), Gaps = 25/450 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSE--I 512
V + + D N+ PVF V E + + A+D+DVG N+ +TY LSS
Sbjct: 119 VDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYF 178
Query: 513 SNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVV 572
+ + +D+ ++ + K LDRE + L +TA DGG P L+ T + ++V+
Sbjct: 179 MLDVNSKNDENKLVE-----LVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVL 233
Query: 573 DVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDP--KDREEGSF 630
DVNDN P F+Q Y I E+A GT+V ++ A+D D G NG I Y + + F
Sbjct: 234 DVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHF 293
Query: 631 VIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESD 690
ID +G I LD E + + A D G PP + V ++I D ND+ P
Sbjct: 294 SIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT 353
Query: 691 CLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVT 750
L+ + E++ GT I I +D D G N V S+ F L + LV
Sbjct: 354 SLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLM---PHVPFKL-VSTFKNYYSLVL 409
Query: 751 MVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDC 807
LD E YELV+ A SP LW + + V DVNDNAP + ++
Sbjct: 410 DSALDRERV-SAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENN 468
Query: 808 FPVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVP 860
P V A DAD + ++ R+ + ++ I ++ +G + L+
Sbjct: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEEL 528
Query: 861 KLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+L +VS D GV + + + L V ++ E
Sbjct: 529 ELLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 122 bits (294), Expect = 2e-26
Identities = 97/326 (29%), Positives = 148/326 (45%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H ++ Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHRDLLEVSLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V++ V DVNDN PVF+ + + E +
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRM 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD---REEGSFVIDPASGVIRTNKALDRESVAT 652
+ GA+DADVG N + Y L D + S + + K+LDRE
Sbjct: 148 PDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPA 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
H L A DGG P + TV + + + D+ND+ P FE I EN+ GTT+ ++ A
Sbjct: 208 HHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNAS 267
Query: 713 DPDEGPNAVVHYSIKGGDDS---NSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPDEG N + YS ++ + FS++ G E+V +LD+E Y+++I A
Sbjct: 268 DPDEGANGAISYSFNSLVETMVIDHFSIDRNTG----EIVIRGNLDFEQ-ENLYKILIDA 322
Query: 770 AS---PPLWNDVRVEILVTDVNDNAP 792
PP+ V + + D NDN P
Sbjct: 323 TDKGHPPMAGHCTVLVRILDKNDNVP 348
>AF152316-1|AAD43710.1| 950|Homo sapiens protocadherin alpha 8
protein.
Length = 950
Score = 231 bits (566), Expect = 2e-59
Identities = 172/614 (28%), Positives = 277/614 (45%), Gaps = 25/614 (4%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ + ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 72 RDLLEVSLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDVNDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
P F K + V E + D+ + A+DADVGANS + Y + + ++S +
Sbjct: 130 PPVFRVKDQKLFVSES-RMPDSRFPLE-GASDADVGANSVLTYRL-SSHDYFMLDVNSKN 186
Query: 207 GDVSLV-----KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
+ LV K+LD E ++ L + A DGG P + T QLL+ + DVNDNAP F S
Sbjct: 187 DENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + EN G +++++ A D DEG N ++Y+ T +D +ID +G +
Sbjct: 247 YEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVID-HFSIDRNTGEIVIR 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G LD E + Y++L+ ATD G PP + T + + ED
Sbjct: 306 GNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF 365
Query: 382 GTPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ D D + + + T +N L+ + LD ++ Y L
Sbjct: 366 GTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRERVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA + + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADA 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 485 QENALVSYSLVERRVGERSL--SSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLY-----TANIMEDALVGTS--VSQVGATDADVG 611
P L +++ V+D NDN P + A+ + VG V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P F + +G I T + LD H L + D G P ++T
Sbjct: 603 YNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 211 bits (515), Expect = 3e-53
Identities = 163/549 (29%), Positives = 242/549 (44%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++DVNDN P F + VSE+ A DAD G N+ LTY ++ DY
Sbjct: 121 VEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYF-M 179
Query: 305 VDLPITIDPRS-GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ D + LDRE + L +TATDGG P + T
Sbjct: 180 LDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSITSQN 418
F +YEV + E+ GT V+ L A+D DE + + Y FSI
Sbjct: 240 PTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNT 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G I + LDF+QE Y + + ATD G + V + I D N+ P +
Sbjct: 300 GE--IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA GT + ++S D D G N Q+T SL + + V+ + ++ +
Sbjct: 358 PVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE +S Y L VTARDGG PSL T + + V DVNDN P F Q YT + E+
Sbjct: 411 SALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S++ + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P + + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ ++S + R G E+ T LD +SPR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPA--ASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 200 bits (488), Expect = 6e-50
Identities = 167/612 (27%), Positives = 265/612 (43%), Gaps = 50/612 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF ++ + V E + A+D D+G N+ + Y +
Sbjct: 118 HVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+ + + L+ R SLDRE + + + ATD P
Sbjct: 178 FMLDVNSKND---------------ENKLVELVLRKSLDREDAPAHHLFLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + V ++D NDN P F + Y V + E + + + K+ A+D D GAN AI
Sbjct: 221 -ELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE--NADNGTTVIKLNASDPDEGANGAI 277
Query: 188 RY---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y +++ FSID +G++ + LD+EQ Y+++I A D G P + +L
Sbjct: 278 SYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ I D NDN P + V E+ G I + D D G N ++T ++ +
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE + Y+L+VTA DGG P ATA+
Sbjct: 393 VPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGRFSITS----Q 417
F +Y V + E+ PPG + T++A DAD ++N L Y + G S++S
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRV-GERSLSSYISVH 511
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------ 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 512 TESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVG 571
Query: 470 -ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+ V G V V A D+D G NA ++Y L S+ + F +
Sbjct: 572 GTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRI-----PFRVGL 626
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
TG I+T ++LD + L V +D G P+L+ T V +S+V+ +Q
Sbjct: 627 YTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGV 686
Query: 589 NIMEDALVGTSV 600
E ALV +V
Sbjct: 687 LGPEAALVDVNV 698
Score = 184 bits (449), Expect = 3e-45
Identities = 118/378 (31%), Positives = 192/378 (50%), Gaps = 12/378 (3%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + LD + + L ++ATD G T VQ+ +T D N+ AP FE + Y +FE
Sbjct: 194 LVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+A GTTV+ ++A+D D G N I+YS +S + + H F I+ TG I LD
Sbjct: 254 NADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDH----FSIDRNTGEIVIRGNLD 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A D G P ++ V + ++D NDN P + + EDA GT +
Sbjct: 310 FEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + D D G NG++ L P + ++ + ALDRE V+ ++L A
Sbjct: 370 ALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRERVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T + +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
Query: 721 VVHYSI---KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWN 776
+V YS+ + G+ S S + S K + +D + E ++++ R A PPL +
Sbjct: 489 LVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 151 bits (366), Expect = 4e-35
Identities = 132/450 (29%), Positives = 202/450 (44%), Gaps = 25/450 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSE--I 512
V + + D N+ PVF V E + + A+D+DVG N+ +TY LSS
Sbjct: 119 VDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYF 178
Query: 513 SNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVV 572
+ + +D+ ++ + K LDRE + L +TA DGG P L+ T + ++V+
Sbjct: 179 MLDVNSKNDENKLVE-----LVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVL 233
Query: 573 DVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDP--KDREEGSF 630
DVNDN P F+Q Y I E+A GT+V ++ A+D D G NG I Y + + F
Sbjct: 234 DVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHF 293
Query: 631 VIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESD 690
ID +G I LD E + + A D G PP + V ++I D ND+ P
Sbjct: 294 SIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT 353
Query: 691 CLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVT 750
L+ + E++ GT I I +D D G N V S+ F L + LV
Sbjct: 354 SLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLM---PHVPFKL-VSTFKNYYSLVL 409
Query: 751 MVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDC 807
LD E YELV+ A SP LW + + V DVNDNAP + ++
Sbjct: 410 DSALDRERV-SAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENN 468
Query: 808 FPVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVP 860
P V A DAD + ++ R+ + ++ I ++ +G + L+
Sbjct: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEEL 528
Query: 861 KLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+L +VS D GV + + + L V ++ E
Sbjct: 529 ELLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 122 bits (294), Expect = 2e-26
Identities = 97/326 (29%), Positives = 148/326 (45%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H ++ Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHRDLLEVSLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V++ V DVNDN PVF+ + + E +
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRM 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD---REEGSFVIDPASGVIRTNKALDRESVAT 652
+ GA+DADVG N + Y L D + S + + K+LDRE
Sbjct: 148 PDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPA 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
H L A DGG P + TV + + + D+ND+ P FE I EN+ GTT+ ++ A
Sbjct: 208 HHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNAS 267
Query: 713 DPDEGPNAVVHYSIKGGDDS---NSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPDEG N + YS ++ + FS++ G E+V +LD+E Y+++I A
Sbjct: 268 DPDEGANGAISYSFNSLVETMVIDHFSIDRNTG----EIVIRGNLDFEQ-ENLYKILIDA 322
Query: 770 AS---PPLWNDVRVEILVTDVNDNAP 792
PP+ V + + D NDN P
Sbjct: 323 TDKGHPPMAGHCTVLVRILDKNDNVP 348
>AC005609-6|AAC34318.1| 814|Homo sapiens KIAA0345-like 6 protein.
Length = 814
Score = 231 bits (566), Expect = 2e-59
Identities = 172/614 (28%), Positives = 277/614 (45%), Gaps = 25/614 (4%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ + ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 72 RDLLEVSLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDVNDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
P F K + V E + D+ + A+DADVGANS + Y + + ++S +
Sbjct: 130 PPVFRVKDQKLFVSES-RMPDSRFPLE-GASDADVGANSVLTYRL-SSHDYFMLDVNSKN 186
Query: 207 GDVSLV-----KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
+ LV K+LD E ++ L + A DGG P + T QLL+ + DVNDNAP F S
Sbjct: 187 DENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSE 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
++ + EN G +++++ A D DEG N ++Y+ T +D +ID +G +
Sbjct: 247 YEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVID-HFSIDRNTGEIVIR 305
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
G LD E + Y++L+ ATD G PP + T + + ED
Sbjct: 306 GNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQF 365
Query: 382 GTPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ D D + + + T +N L+ + LD ++ Y L
Sbjct: 366 GTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRERVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA + + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADA 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 485 QENALVSYSLVERRVGERSL--SSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVFKQQLY-----TANIMEDALVGTS--VSQVGATDADVG 611
P L +++ V+D NDN P + A+ + VG V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P F + +G I T + LD H L + D G P ++T
Sbjct: 603 YNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 211 bits (515), Expect = 3e-53
Identities = 163/549 (29%), Positives = 242/549 (44%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++DVNDN P F + VSE+ A DAD G N+ LTY ++ DY
Sbjct: 121 VEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYF-M 179
Query: 305 VDLPITIDPRS-GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ D + LDRE + L +TATDGG P + T
Sbjct: 180 LDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSITSQN 418
F +YEV + E+ GT V+ L A+D DE + + Y FSI
Sbjct: 240 PTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNT 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G I + LDF+QE Y + + ATD G + V + I D N+ P +
Sbjct: 300 GE--IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA GT + ++S D D G N Q+T SL + + V+ + ++ +
Sbjct: 358 PVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE +S Y L VTARDGG PSL T + + V DVNDN P F Q YT + E+
Sbjct: 411 SALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S++ + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P + + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ ++S + R G E+ T LD +SPR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPA--ASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 200 bits (488), Expect = 6e-50
Identities = 167/612 (27%), Positives = 265/612 (43%), Gaps = 50/612 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF ++ + V E + A+D D+G N+ + Y +
Sbjct: 118 HVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+ + + L+ R SLDRE + + + ATD P
Sbjct: 178 FMLDVNSKND---------------ENKLVELVLRKSLDREDAPAHHLFLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + V ++D NDN P F + Y V + E + + + K+ A+D D GAN AI
Sbjct: 221 -ELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE--NADNGTTVIKLNASDPDEGANGAI 277
Query: 188 RY---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y +++ FSID +G++ + LD+EQ Y+++I A D G P + +L
Sbjct: 278 SYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ I D NDN P + V E+ G I + D D G N ++T ++ +
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE + Y+L+VTA DGG P ATA+
Sbjct: 393 VPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGRFSITS----Q 417
F +Y V + E+ PPG + T++A DAD ++N L Y + G S++S
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRV-GERSLSSYISVH 511
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------ 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 512 TESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVG 571
Query: 470 -ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
+ V G V V A D+D G NA ++Y L S+ + F +
Sbjct: 572 GTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRI-----PFRVGL 626
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTA 588
TG I+T ++LD + L V +D G P+L+ T V +S+V+ +Q
Sbjct: 627 YTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGV 686
Query: 589 NIMEDALVGTSV 600
E ALV +V
Sbjct: 687 LGPEAALVDVNV 698
Score = 184 bits (449), Expect = 3e-45
Identities = 118/378 (31%), Positives = 192/378 (50%), Gaps = 12/378 (3%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + LD + + L ++ATD G T VQ+ +T D N+ AP FE + Y +FE
Sbjct: 194 LVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+A GTTV+ ++A+D D G N I+YS +S + + H F I+ TG I LD
Sbjct: 254 NADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDH----FSIDRNTGEIVIRGNLD 309
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A D G P ++ V + ++D NDN P + + EDA GT +
Sbjct: 310 FEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVI 369
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + D D G NG++ L P + ++ + ALDRE V+ ++L A
Sbjct: 370 ALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRERVSAYELVVTAR 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T + +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 429 DGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
Query: 721 VVHYSI---KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWN 776
+V YS+ + G+ S S + S K + +D + E ++++ R A PPL +
Sbjct: 489 LVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 151 bits (366), Expect = 4e-35
Identities = 132/450 (29%), Positives = 202/450 (44%), Gaps = 25/450 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSE--I 512
V + + D N+ PVF V E + + A+D+DVG N+ +TY LSS
Sbjct: 119 VDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYF 178
Query: 513 SNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVV 572
+ + +D+ ++ + K LDRE + L +TA DGG P L+ T + ++V+
Sbjct: 179 MLDVNSKNDENKLVE-----LVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVL 233
Query: 573 DVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDP--KDREEGSF 630
DVNDN P F+Q Y I E+A GT+V ++ A+D D G NG I Y + + F
Sbjct: 234 DVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHF 293
Query: 631 VIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESD 690
ID +G I LD E + + A D G PP + V ++I D ND+ P
Sbjct: 294 SIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT 353
Query: 691 CLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVT 750
L+ + E++ GT I I +D D G N V S+ F L + LV
Sbjct: 354 SLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLM---PHVPFKL-VSTFKNYYSLVL 409
Query: 751 MVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDC 807
LD E YELV+ A SP LW + + V DVNDNAP + ++
Sbjct: 410 DSALDRERV-SAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENN 468
Query: 808 FPVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVP 860
P V A DAD + ++ R+ + ++ I ++ +G + L+
Sbjct: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEEL 528
Query: 861 KLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+L +VS D GV + + + L V ++ E
Sbjct: 529 ELLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 122 bits (294), Expect = 2e-26
Identities = 97/326 (29%), Positives = 148/326 (45%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H ++ Q G + N
Sbjct: 34 SVPEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHRDLLEVSLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V++ V DVNDN PVF+ + + E +
Sbjct: 88 SRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRM 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD---REEGSFVIDPASGVIRTNKALDRESVAT 652
+ GA+DADVG N + Y L D + S + + K+LDRE
Sbjct: 148 PDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPA 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
H L A DGG P + TV + + + D+ND+ P FE I EN+ GTT+ ++ A
Sbjct: 208 HHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNAS 267
Query: 713 DPDEGPNAVVHYSIKGGDDS---NSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPDEG N + YS ++ + FS++ G E+V +LD+E Y+++I A
Sbjct: 268 DPDEGANGAISYSFNSLVETMVIDHFSIDRNTG----EIVIRGNLDFEQ-ENLYKILIDA 322
Query: 770 AS---PPLWNDVRVEILVTDVNDNAP 792
PP+ V + + D NDN P
Sbjct: 323 TDKGHPPMAGHCTVLVRILDKNDNVP 348
>BC105111-1|AAI05112.1| 884|Homo sapiens protocadherin alpha
subfamily C, 2, isoform 2 precursor protein.
Length = 884
Score = 228 bits (558), Expect = 2e-58
Identities = 173/584 (29%), Positives = 266/584 (45%), Gaps = 56/584 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ +LD ND+SP F Y+ V E + G A D D+G N+ Y
Sbjct: 135 EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTY--------E 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
L+P + V L+ R LDRE+ A + +++ A D P
Sbjct: 187 LSPSEHFELDLKPLQENSKVLE-------LVLRKGLDREQAALHHLVLTAVDGGIPAR-- 237
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S TA I V ++D NDN P F + TY V + ED ++ K+ A+D D G+N +RY
Sbjct: 238 -SGTAQISVRVLDTNDNSPAFDQSTYRVQLRED--SPPGTLVVKLNASDPDEGSNGELRY 294
Query: 190 AIIGGNTQMQ---FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++ + + FSID+ +G+V ++ LDYE+ SY++ ++A D G + ++L++
Sbjct: 295 SLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVD 354
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I DVNDNAP + V EN + + D D G N +++ +
Sbjct: 355 IVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-------EAT 407
Query: 307 LPITID--PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
LP ++ S + SG LDRE A Y + VTATDGG P ++ T
Sbjct: 408 LPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPP 467
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR-------LHYEITGGNTRGRFSITSQ 417
F+ Y + + E+ PG + T+ ATD DE L EI G SI S
Sbjct: 468 SFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSA 527
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAP 473
+G + D+++ R + +TV A D G S T + + D N++AP ++ +
Sbjct: 528 SGS--LYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTST 585
Query: 474 YTASVFE----DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++ FE AP G V V A DSD G NA + Y L+ + F +
Sbjct: 586 NSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDL-------FKVELH 638
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I T + + E+ S + LTV RD G PSLS + + ++VVD
Sbjct: 639 TGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682
Score = 228 bits (557), Expect = 3e-58
Identities = 177/603 (29%), Positives = 275/603 (45%), Gaps = 27/603 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D SGAL +DRE + + ++ + + + V I+D NDN P+F
Sbjct: 92 LDLTSGALFVNERIDREALCEQRP--RCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG---- 207
Y + V E SV A D DVGANS Y + + + + L
Sbjct: 150 RPNYQLQVSE--SVAPGARFHIESAQDPDVGANSVQTYEL-SPSEHFELDLKPLQENSKV 206
Query: 208 -DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD EQ + LV+ A DGG P+RS T Q+ + + D NDN+P F S ++ +
Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQL 266
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLD 325
E+ P G +V++ A D DEG N EL Y+++ YT + + + +ID +G V G LD
Sbjct: 267 REDSPPGTLVVKLNASDPDEGSNGELRYSLS--SYTSDRERQLFSIDASTGEVRVIGGLD 324
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E + YQ+ V ATD G P + + + E+ P T V
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIV 384
Query: 386 VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATD 445
L+ D D + G F + + V+ PLD ++ Y +TV+ATD
Sbjct: 385 AVLSVNDQDSGPNRKVSL-GLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATD 443
Query: 446 SGGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T++ +++ I+D N+ P F Y+ + E+ G + V ATD D NA+
Sbjct: 444 GGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAE 503
Query: 504 ITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
+TYS L EI V + IN +G++ D E + +TV A+D G P LS
Sbjct: 504 VTYSLLEREIQGLPVTSY---VSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLS 560
Query: 563 DTTDVEISVVDVNDNEPVFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLNGRI 616
T + VVD+ND+ P T + + A G V++V A D+D G N +
Sbjct: 561 STVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWL 620
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
Y L + + F ++ +G IRT + + ES +T +L V D G P S++V + +
Sbjct: 621 FYHL-AQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVA 679
Query: 677 IED 679
+ D
Sbjct: 680 VVD 682
Score = 183 bits (446), Expect = 7e-45
Identities = 166/604 (27%), Positives = 279/604 (46%), Gaps = 37/604 (6%)
Query: 309 ITIDPRSGWVYTSGQLDRET--QAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+ +D SG ++ + ++DRE + + + L++ P + +A
Sbjct: 90 LELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGG-NTRGRFSITSQNGRGL- 422
P Y+++++E PG +A D D N + YE++ + +N + L
Sbjct: 150 RPN-YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLE 208
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +Q + L ++A D G RS TA + + + D N+ +P F+ + Y + E
Sbjct: 209 LVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLRE 268
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
D+P GT V+ ++A+D D G N ++ YSLSS S+ Q F I+ TG + LD
Sbjct: 269 DSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDR----ERQLFSIDASTGEVRVIGGLD 324
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALVGTS 599
E S Y + V A D G ++ V + +VDVNDN P V LY+ + E+A T
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP-VPENATPNTI 383
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
V+ + D D G N ++ L+ + + + V+ + LDRE VA +++ A
Sbjct: 384 VAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVV--SGPLDRERVAVYNITVTA 441
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG P +S + ++I DIND+PP F D + YI EN+ G + ++A DPDE N
Sbjct: 442 TDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKEN 501
Query: 720 AVVHYS-----IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR--AASP 772
A V YS I+G ++ S+ + GS L + DYE R+ + V SP
Sbjct: 502 AEVTYSLLEREIQGLPVTSYVSINSASGS----LYAVNSFDYEKFREFFVTVEAQDKGSP 557
Query: 773 PLWNDVRVEILVTDVNDNA-----PVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
PL + V + V D+ND+A P + F P G +V A D+D
Sbjct: 558 PLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQN 617
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLS 883
L Y + ++ +L + TG + + ++ + V V D G + A + ++
Sbjct: 618 AWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAIT 677
Query: 884 VRLI 887
V ++
Sbjct: 678 VAVV 681
>BC104776-1|AAI04777.1| 884|Homo sapiens protocadherin alpha
subfamily C, 2, isoform 2 precursor protein.
Length = 884
Score = 228 bits (558), Expect = 2e-58
Identities = 173/584 (29%), Positives = 266/584 (45%), Gaps = 56/584 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ +LD ND+SP F Y+ V E + G A D D+G N+ Y
Sbjct: 135 EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTY--------E 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
L+P + V L+ R LDRE+ A + +++ A D P
Sbjct: 187 LSPSEHFELDLKPLQENSKVLE-------LVLRKGLDREQAALHHLVLTAVDGGIPAR-- 237
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S TA I V ++D NDN P F + TY V + ED ++ K+ A+D D G+N +RY
Sbjct: 238 -SGTAQISVRVLDTNDNSPAFDQSTYRVQLRED--SPPGTLVVKLNASDPDEGSNGELRY 294
Query: 190 AIIGGNTQMQ---FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++ + + FSID+ +G+V ++ LDYE+ SY++ ++A D G + ++L++
Sbjct: 295 SLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVD 354
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I DVNDNAP + V EN + + D D G N +++ +
Sbjct: 355 IVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-------EAT 407
Query: 307 LPITID--PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
LP ++ S + SG LDRE A Y + VTATDGG P ++ T
Sbjct: 408 LPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPP 467
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR-------LHYEITGGNTRGRFSITSQ 417
F+ Y + + E+ PG + T+ ATD DE L EI G SI S
Sbjct: 468 SFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSA 527
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAP 473
+G + D+++ R + +TV A D G S T + + D N++AP ++ +
Sbjct: 528 SGS--LYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTST 585
Query: 474 YTASVFE----DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++ FE AP G V V A DSD G NA + Y L+ + F +
Sbjct: 586 NSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDL-------FKVELH 638
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I T + + E+ S + LTV RD G PSLS + + ++VVD
Sbjct: 639 TGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682
Score = 228 bits (557), Expect = 3e-58
Identities = 177/603 (29%), Positives = 275/603 (45%), Gaps = 27/603 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D SGAL +DRE + + ++ + + + V I+D NDN P+F
Sbjct: 92 LDLTSGALFVNERIDREALCEQRP--RCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG---- 207
Y + V E SV A D DVGANS Y + + + + L
Sbjct: 150 RPNYQLQVSE--SVAPGARFHIESAQDPDVGANSVQTYEL-SPSEHFELDLKPLQENSKV 206
Query: 208 -DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD EQ + LV+ A DGG P+RS T Q+ + + D NDN+P F S ++ +
Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQL 266
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLD 325
E+ P G +V++ A D DEG N EL Y+++ YT + + + +ID +G V G LD
Sbjct: 267 REDSPPGTLVVKLNASDPDEGSNGELRYSLS--SYTSDRERQLFSIDASTGEVRVIGGLD 324
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E + YQ+ V ATD G P + + + E+ P T V
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIV 384
Query: 386 VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATD 445
L+ D D + G F + + V+ PLD ++ Y +TV+ATD
Sbjct: 385 AVLSVNDQDSGPNRKVSL-GLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATD 443
Query: 446 SGGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T++ +++ I+D N+ P F Y+ + E+ G + V ATD D NA+
Sbjct: 444 GGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAE 503
Query: 504 ITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
+TYS L EI V + IN +G++ D E + +TV A+D G P LS
Sbjct: 504 VTYSLLEREIQGLPVTSY---VSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLS 560
Query: 563 DTTDVEISVVDVNDNEPVFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLNGRI 616
T + VVD+ND+ P T + + A G V++V A D+D G N +
Sbjct: 561 STVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWL 620
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
Y L + + F ++ +G IRT + + ES +T +L V D G P S++V + +
Sbjct: 621 FYHL-AQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVA 679
Query: 677 IED 679
+ D
Sbjct: 680 VVD 682
Score = 183 bits (446), Expect = 7e-45
Identities = 166/604 (27%), Positives = 279/604 (46%), Gaps = 37/604 (6%)
Query: 309 ITIDPRSGWVYTSGQLDRET--QAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+ +D SG ++ + ++DRE + + + L++ P + +A
Sbjct: 90 LELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGG-NTRGRFSITSQNGRGL- 422
P Y+++++E PG +A D D N + YE++ + +N + L
Sbjct: 150 RPN-YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLE 208
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +Q + L ++A D G RS TA + + + D N+ +P F+ + Y + E
Sbjct: 209 LVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLRE 268
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
D+P GT V+ ++A+D D G N ++ YSLSS S+ Q F I+ TG + LD
Sbjct: 269 DSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDR----ERQLFSIDASTGEVRVIGGLD 324
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALVGTS 599
E S Y + V A D G ++ V + +VDVNDN P V LY+ + E+A T
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP-VPENATPNTI 383
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
V+ + D D G N ++ L+ + + + V+ + LDRE VA +++ A
Sbjct: 384 VAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVV--SGPLDRERVAVYNITVTA 441
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG P +S + ++I DIND+PP F D + YI EN+ G + ++A DPDE N
Sbjct: 442 TDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKEN 501
Query: 720 AVVHYS-----IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR--AASP 772
A V YS I+G ++ S+ + GS L + DYE R+ + V SP
Sbjct: 502 AEVTYSLLEREIQGLPVTSYVSINSASGS----LYAVNSFDYEKFREFFVTVEAQDKGSP 557
Query: 773 PLWNDVRVEILVTDVNDNA-----PVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
PL + V + V D+ND+A P + F P G +V A D+D
Sbjct: 558 PLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQN 617
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLS 883
L Y + ++ +L + TG + + ++ + V V D G + A + ++
Sbjct: 618 AWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAIT 677
Query: 884 VRLI 887
V ++
Sbjct: 678 VAVV 681
>BC063288-1|AAH63288.1| 1007|Homo sapiens protocadherin alpha
subfamily C, 2 protein.
Length = 1007
Score = 228 bits (558), Expect = 2e-58
Identities = 173/584 (29%), Positives = 266/584 (45%), Gaps = 56/584 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ +LD ND+SP F Y+ V E + G A D D+G N+ Y
Sbjct: 135 EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTY--------E 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
L+P + V L+ R LDRE+ A + +++ A D P
Sbjct: 187 LSPSEHFELDLKPLQENSKVLE-------LVLRKGLDREQAALHHLVLTAVDGGIPAR-- 237
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S TA I V ++D NDN P F + TY V + ED ++ K+ A+D D G+N +RY
Sbjct: 238 -SGTAQISVRVLDTNDNSPAFDQSTYRVQLRED--SPPGTLVVKLNASDPDEGSNGELRY 294
Query: 190 AIIGGNTQMQ---FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++ + + FSID+ +G+V ++ LDYE+ SY++ ++A D G + ++L++
Sbjct: 295 SLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVD 354
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I DVNDNAP + V EN + + D D G N +++ +
Sbjct: 355 IVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-------EAT 407
Query: 307 LPITID--PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
LP ++ S + SG LDRE A Y + VTATDGG P ++ T
Sbjct: 408 LPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPP 467
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR-------LHYEITGGNTRGRFSITSQ 417
F+ Y + + E+ PG + T+ ATD DE L EI G SI S
Sbjct: 468 SFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSA 527
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAP 473
+G + D+++ R + +TV A D G S T + + D N++AP ++ +
Sbjct: 528 SGS--LYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTST 585
Query: 474 YTASVFE----DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++ FE AP G V V A DSD G NA + Y L+ + F +
Sbjct: 586 NSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDL-------FKVELH 638
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I T + + E+ S + LTV RD G PSLS + + ++VVD
Sbjct: 639 TGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682
Score = 228 bits (557), Expect = 3e-58
Identities = 177/603 (29%), Positives = 275/603 (45%), Gaps = 27/603 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D SGAL +DRE + + ++ + + + V I+D NDN P+F
Sbjct: 92 LDLTSGALFVNERIDREALCEQRP--RCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG---- 207
Y + V E SV A D DVGANS Y + + + + L
Sbjct: 150 RPNYQLQVSE--SVAPGARFHIESAQDPDVGANSVQTYEL-SPSEHFELDLKPLQENSKV 206
Query: 208 -DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD EQ + LV+ A DGG P+RS T Q+ + + D NDN+P F S ++ +
Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQL 266
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLD 325
E+ P G +V++ A D DEG N EL Y+++ YT + + + +ID +G V G LD
Sbjct: 267 REDSPPGTLVVKLNASDPDEGSNGELRYSLS--SYTSDRERQLFSIDASTGEVRVIGGLD 324
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E + YQ+ V ATD G P + + + E+ P T V
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIV 384
Query: 386 VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATD 445
L+ D D + G F + + V+ PLD ++ Y +TV+ATD
Sbjct: 385 AVLSVNDQDSGPNRKVSL-GLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATD 443
Query: 446 SGGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T++ +++ I+D N+ P F Y+ + E+ G + V ATD D NA+
Sbjct: 444 GGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAE 503
Query: 504 ITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
+TYS L EI V + IN +G++ D E + +TV A+D G P LS
Sbjct: 504 VTYSLLEREIQGLPVTSY---VSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLS 560
Query: 563 DTTDVEISVVDVNDNEPVFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLNGRI 616
T + VVD+ND+ P T + + A G V++V A D+D G N +
Sbjct: 561 STVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWL 620
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
Y L + + F ++ +G IRT + + ES +T +L V D G P S++V + +
Sbjct: 621 FYHL-AQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVA 679
Query: 677 IED 679
+ D
Sbjct: 680 VVD 682
Score = 183 bits (446), Expect = 7e-45
Identities = 166/604 (27%), Positives = 279/604 (46%), Gaps = 37/604 (6%)
Query: 309 ITIDPRSGWVYTSGQLDRET--QAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+ +D SG ++ + ++DRE + + + L++ P + +A
Sbjct: 90 LELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGG-NTRGRFSITSQNGRGL- 422
P Y+++++E PG +A D D N + YE++ + +N + L
Sbjct: 150 RPN-YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLE 208
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +Q + L ++A D G RS TA + + + D N+ +P F+ + Y + E
Sbjct: 209 LVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLRE 268
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
D+P GT V+ ++A+D D G N ++ YSLSS S+ Q F I+ TG + LD
Sbjct: 269 DSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDR----ERQLFSIDASTGEVRVIGGLD 324
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALVGTS 599
E S Y + V A D G ++ V + +VDVNDN P V LY+ + E+A T
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP-VPENATPNTI 383
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
V+ + D D G N ++ L+ + + + V+ + LDRE VA +++ A
Sbjct: 384 VAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVV--SGPLDRERVAVYNITVTA 441
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG P +S + ++I DIND+PP F D + YI EN+ G + ++A DPDE N
Sbjct: 442 TDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKEN 501
Query: 720 AVVHYS-----IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR--AASP 772
A V YS I+G ++ S+ + GS L + DYE R+ + V SP
Sbjct: 502 AEVTYSLLEREIQGLPVTSYVSINSASGS----LYAVNSFDYEKFREFFVTVEAQDKGSP 557
Query: 773 PLWNDVRVEILVTDVNDNA-----PVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
PL + V + V D+ND+A P + F P G +V A D+D
Sbjct: 558 PLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQN 617
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLS 883
L Y + ++ +L + TG + + ++ + V V D G + A + ++
Sbjct: 618 AWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAIT 677
Query: 884 VRLI 887
V ++
Sbjct: 678 VAVV 681
>AY358946-1|AAQ89305.1| 916|Homo sapiens cadherin FIB3 protein.
Length = 916
Score = 228 bits (558), Expect = 2e-58
Identities = 186/607 (30%), Positives = 277/607 (45%), Gaps = 30/607 (4%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + + + D++ + V + D NDN P
Sbjct: 74 LFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDIL-MEDKVKIYG-VEVEVRDINDNAP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSID----- 203
F E + + E+ + + A D D+G NS Y + NT +
Sbjct: 132 YFRESELEIKISENAATEMRFPLPH--AWDPDIGKNSLQSYEL-SPNTHFSLIVQNGADG 188
Query: 204 SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
S ++ L + LD E+ ++ LV+ A DGG P R+ T ++ + + D NDNAP F ++
Sbjct: 189 SKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYR 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
SV EN+ +G ++ V A D DEGVNAE+ Y+ D +D SG + T G+
Sbjct: 249 ASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVD--DKAAQVFKLDCNSGTISTIGE 306
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E YQ+ V A D SA A + + E+ P GT
Sbjct: 307 LDHEESGFYQMEVQAMDNAG--YSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGT 364
Query: 384 PVVTLTATDAD-EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
+ L D D E+N GN + + N L+T LD +Q Y +TV+
Sbjct: 365 LIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDI-VLDREQVPSYNITVT 423
Query: 443 ATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S + +N+ D N+ PVF A Y+A + E+ P G +++ V+A D D
Sbjct: 424 ATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEE 483
Query: 501 NAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
NAQITYSL+ A IN TG + D E + V ARD G P
Sbjct: 484 NAQITYSLAENTIQGASL--SSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPP 541
Query: 561 LSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLN 613
LS + + V+D NDN P + L T A G V++V A D D G N
Sbjct: 542 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSSTVI 672
+ Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+TV
Sbjct: 602 AWLSYRL-LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSATVT 659
Query: 673 VHIKIED 679
+ + + D
Sbjct: 660 LTVAVAD 666
Score = 188 bits (459), Expect = 2e-46
Identities = 169/585 (28%), Positives = 261/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND++P F + E + E A++ A D DIGKN+ Y + T +
Sbjct: 120 EVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFS 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L ++ DG + L+ + +LDRE+ A + +++ A+D PV
Sbjct: 180 LIVQNGA----------------DGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ TA I V ++D NDN P F++ Y SV E++++ ++ + ATD D G N+ +R
Sbjct: 223 --TGTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLV--VNATDPDEGVNAEVR 278
Query: 189 YAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ + F +D SG +S + LD+E+ Y++ ++A D + S ++LI
Sbjct: 279 YSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMD--NAGYSARAKVLIT 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDNAP + SV EN P G I + D D N ++ + GN
Sbjct: 337 VLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDSEENGQVICFI-----QGN-- 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ G Y T LDRE Y + VTATD G PP S
Sbjct: 390 LPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G +V++TA D D E+ ++ Y + +G S S N
Sbjct: 450 PVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINS 509
Query: 420 -RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAP--VFENAPY 474
G++ D++Q R + V A D+G S + + + D N+ AP ++ P
Sbjct: 510 DTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPT 569
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 570 DGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK-------ASEPGLFSVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 186 bits (454), Expect = 8e-46
Identities = 166/601 (27%), Positives = 279/601 (46%), Gaps = 42/601 (6%)
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTAT-DGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE + D + F
Sbjct: 77 LNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRES 136
Query: 370 QYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRG-----L 422
+ E++++E+ A D D +++ YE++ NT FS+ QNG
Sbjct: 137 ELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSP-NTH--FSLIVQNGADGSKYPE 193
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +++ + L ++A+D G R+ TA +++ + DAN+ AP F Y ASV E
Sbjct: 194 LVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ +GT +LVV+ATD D G+NA++ YS + ++A Q F ++ +G I+T LD
Sbjct: 254 NLALGTQLLVVNATDPDEGVNAEVRYSFRY-VDDKAA----QVFKLDCNSGTISTIGELD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A D S V I+V+DVNDN P +++ E++ GT +
Sbjct: 309 HEESGFYQMEVQAMDNA--GYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLI 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ + D D NG++ + + F ++ + G + T+ LDRE V ++++
Sbjct: 367 ALLNVNDQDSEENGQVICFI----QGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITV 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP S+ + + + D ND+PPVF + YI EN+P G ++ + AHDPD
Sbjct: 423 TATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCE 482
Query: 718 PNAVVHYSI-KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPPL 774
NA + YS+ + S S SD L + DYE R + +++ R PPL
Sbjct: 483 ENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPL 542
Query: 775 WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------DADVT 824
++V + + V D NDNAP + + + + + P P Y D+
Sbjct: 543 SSNVSLSLFVLDQNDNAPEIL-YPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601
Query: 825 DKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLS 883
L YR+L + L + TG + + L ++ V+V D G + A + L+
Sbjct: 602 AWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLT 661
Query: 884 V 884
V
Sbjct: 662 V 662
Score = 168 bits (409), Expect = 2e-40
Identities = 139/472 (29%), Positives = 211/472 (44%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD ND++P F +Y ASV E + GT +L + ATD D G NAEV Y+ V
Sbjct: 229 RVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYV---- 284
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D VF++D SG + T LD E+ Y + V+A D A
Sbjct: 285 ---DDKAA----------QVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAG----- 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S+ A + + ++D NDN P+ + SV E + +IA + D D N +
Sbjct: 327 YSARAKVLITVLDVNDNAPEVVLTSLASSVPE--NSPRGTLIALLNVNDQDSEENGQV-I 383
Query: 190 AIIGGNTQMQFSIDSLSGD-VSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I GN + F ++ G+ SLV LD EQV SY + + A D G+P S T + +N
Sbjct: 384 CFIQGN--LPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLN 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ D NDN P F + + + EN P G S+V V A+D D NA++TY++ + G ++
Sbjct: 442 VADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E Q+ V A D G PP S+ +
Sbjct: 502 SSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPE 561
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G VELA PG V + A D D L Y + + G FS+
Sbjct: 562 ILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A++ V
Sbjct: 622 HTGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQV 671
Score = 124 bits (300), Expect = 3e-27
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 16/280 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETM-SGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP++G++ T +DRE + G + D + VE+ V D+NDN P
Sbjct: 73 QLFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPY 132
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--- 637
F++ I E+A A D D+G N YEL P + V + A G
Sbjct: 133 FRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSP-NTHFSLIVQNGADGSKY 191
Query: 638 -VIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYI 696
+ +ALDRE A H L A DGG P ++ T + + + D ND+ P F +
Sbjct: 192 PELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASV 251
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDL 754
EN +GT + + A DPDEG NA V YS + DD + F L+ G+ + T+ +L
Sbjct: 252 PENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGT----ISTIGEL 307
Query: 755 DYESPRKKYELVIRAASPPLWNDVRVEILVT--DVNDNAP 792
D+E Y++ ++A ++ R ++L+T DVNDNAP
Sbjct: 308 DHEE-SGFYQMEVQAMDNAGYS-ARAKVLITVLDVNDNAP 345
Score = 84.2 bits (199), Expect = 6e-15
Identities = 62/247 (25%), Positives = 104/247 (42%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H +NV D ND+ PVF Y A + E G +++++ A D D +NA++ Y++
Sbjct: 437 HISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSL---AE 493
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+T+ + I+ +G L +S D E+ V V A D P
Sbjct: 494 NTIQ-----------GASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHP-- 540
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDI-----SVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN P+ + S ++ K+ A D D G
Sbjct: 541 -PLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG 599
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ + FS+ +G+V + L LV+ QD G P S T
Sbjct: 600 QNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT 659
Query: 243 LLINIRD 249
L + + D
Sbjct: 660 LTVAVAD 666
Score = 72.5 bits (170), Expect = 2e-11
Identities = 62/203 (30%), Positives = 95/203 (46%), Gaps = 16/203 (7%)
Query: 601 SQVGATDADVGLNGRIHYE----LDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
S+VG D+GL R E + P+ R + F ++P SG + T +DRE + +K
Sbjct: 43 SRVGDISRDLGLEPRELAERGVRIIPRGRTQ-LFALNPRSGSLVTAGRIDREELCMGAIK 101
Query: 657 A-VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+ +D + V +++ DIND+ P F L ISEN+ A DPD
Sbjct: 102 CQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPD 161
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKYELVIRAA-- 770
G N++ Y + + FSL + G+D + ELV LD E + + LV+ A+
Sbjct: 162 IGKNSLQSYEL---SPNTHFSLIVQNGADGSKYPELVLKRALDREE-KAAHHLVLTASDG 217
Query: 771 -SPPLWNDVRVEILVTDVNDNAP 792
P R+ ++V D NDNAP
Sbjct: 218 GDPVRTGTARIRVMVLDANDNAP 240
>AJ007609-1|CAC22256.1| 949|Homo sapiens protocadherin alpha 11
protein.
Length = 949
Score = 228 bits (558), Expect = 2e-58
Identities = 179/618 (28%), Positives = 291/618 (47%), Gaps = 36/618 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR ++V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGQSA--ECSIHLEVIVDRPLQVFHVNVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P FS + + + E S + A+DAD+ N+ + Y + + FS+DS +
Sbjct: 131 PVFSLREQKLLIAE--SKQSDSRFPLEGASDADIEENALLTYRL---SKNEYFSLDSPTN 185
Query: 208 D-----VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
+SL+ K+LD E+ L++ A DGG P + T +LL+ + DVNDN P F S
Sbjct: 186 GKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKS 245
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
++ S+ EN ++++ A D DEGVN E+TY++ G T+D +G V
Sbjct: 246 EYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR--HLFTLDQNNGEVRV 303
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
+G LD E Y++ V ATD G PP + T + + ED
Sbjct: 304 NGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQ 363
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRY 437
P T + ++ +D D+ ++ ++T T F + S +N L+ + LD + Y
Sbjct: 364 PSTVIALISV--SDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRENVWAY 420
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D
Sbjct: 421 ELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD 480
Query: 496 SDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
+D NA ++YSL + + A++ + ++ ++G + + LD E + V+AR
Sbjct: 481 ADAQENALVSYSLVERRLGDRALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSAR 537
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATD 607
D GVP LS +++ V+D NDN P + Q +A + LV G V++V A D
Sbjct: 538 DAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVD 597
Query: 608 ADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
AD G N + YEL P F + +G I T +ALD H L + D G P
Sbjct: 598 ADSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPA 657
Query: 667 QSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 658 LTATATVLVSLVESGQAP 675
Score = 211 bits (516), Expect = 2e-53
Identities = 174/609 (28%), Positives = 271/609 (44%), Gaps = 45/609 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF +++ + + E S + A+D DI +NA + Y +
Sbjct: 118 HVNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+L+ + + R+ +L+ + SLDREK +L+ ATD P
Sbjct: 178 FSLDSPTNG----------KQIKRL-----SLILKKSLDREKTPELNLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + V ++D NDN P+F + Y VS+ E+ + ++ K+ ATD D G N +
Sbjct: 221 -ELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAA--KETLVLKLNATDRDEGVNGEV 277
Query: 188 RYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y++ I N + F++D +G+V + TLDYE+ + Y++ ++A D G+P + + +
Sbjct: 278 TYSLMSIKPNGRHLFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWV 337
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D NDN+P + V E+ I + D D GVN ++T ++T
Sbjct: 338 EILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHV---PF 394
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
L T V S LDRE Y+L+VTA DGG P ATA
Sbjct: 395 KLVSTFKNYYSLVLDSA-LDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPA 453
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR- 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 454 FAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAES 513
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF-------EN 471
G + QPLD ++ VSA D+G S +Q+ + D N+ AP
Sbjct: 514 GKVYALQPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAG 573
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
V G V V A D+D G NA ++Y L + F + TG
Sbjct: 574 GAVNKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIP-----FRVGLYTG 628
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 629 EISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRTLAGAASP 688
Query: 592 EDALVGTSV 600
E ALV +V
Sbjct: 689 EAALVDVNV 697
Score = 210 bits (513), Expect = 5e-53
Identities = 159/546 (29%), Positives = 244/546 (44%), Gaps = 27/546 (4%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ A DAD NA LTY ++ +Y +
Sbjct: 121 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYF-S 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D P + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDND 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F +Y+V L E+ T V+ L ATD DE + + Y + GR T G
Sbjct: 240 PEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNG 299
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ V LD+++ + Y + V ATD G + V + I D N+ +P + V
Sbjct: 300 EVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVR 359
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
EDA T + ++S +D D G+N Q+T SL+ + + V+ + ++ + L
Sbjct: 360 EDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYY-------SLVLDSAL 412
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
DRE + Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 413 DRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCH 472
Query: 600 VSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATHDL 655
+ V A DAD N + Y L + DR S+V + SG + + LD E +
Sbjct: 473 IFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQF 532
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGE 708
+ A D G PP SS V + + + D ND+ P + + + G + +
Sbjct: 533 QVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAK 592
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYELVI 767
+RA D D G NA + Y ++ + + R G E+ T LD +SPR + +++
Sbjct: 593 VRAVDADSGYNAWLSYELQPA--AGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLV 650
Query: 768 RAASPP 773
+ P
Sbjct: 651 KDHGEP 656
Score = 177 bits (431), Expect = 5e-43
Identities = 127/415 (30%), Positives = 206/415 (49%), Gaps = 17/415 (4%)
Query: 390 ATDAD-EDNRL-HYEITGGNTRGRFSITS--QNGRGLITVAQPLDFKQERRYVLTVSATD 445
A+DAD E+N L Y ++ S T+ Q R + + + LD ++ L ++ATD
Sbjct: 157 ASDADIEENALLTYRLSKNEYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATD 216
Query: 446 SGGRSDTAMVQ--INITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T V+ + + D N+ P F+ + Y S+ E+A T VL ++ATD D G+N +
Sbjct: 217 GGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGE 276
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
+TYSL S N H F ++ G + N LD E Y + V A D G P ++
Sbjct: 277 VTYSLMSIKPN---GRH--LFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAG 331
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
V + ++D NDN P + + EDA T ++ + +D D G+NG++ L P
Sbjct: 332 HCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPH 391
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
+ ++ + ALDRE+V ++L A DGG+P +T V +++ D+ND+
Sbjct: 392 VPFKLVSTFKNYYSLV-LDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDN 450
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI---KGGDDSNSFSLETR 740
P F T ++ EN+P G I + A D D NA+V YS+ + GD + S +
Sbjct: 451 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVH 510
Query: 741 QGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVRVEILVTDVNDNAPVM 794
S K + +D + E ++++ R A PPL ++V +++ V D NDNAP +
Sbjct: 511 AESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPAL 564
Score = 157 bits (382), Expect = 4e-37
Identities = 133/447 (29%), Positives = 202/447 (45%), Gaps = 20/447 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + + D N+ PVF + E + + A+D+D+ NA +TY LS N
Sbjct: 119 VNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSK---N 175
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
E + + ++ K LDRE L +TA DGG P L+ T + + V+DV
Sbjct: 176 EYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDV 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL-DPKDREEGSFVID 633
NDN+P F + Y ++ME+A T V ++ ATD D G+NG + Y L K F +D
Sbjct: 236 NDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLD 295
Query: 634 PASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+G +R N LD E + ++ A D GTPP + V ++I D ND+ P L+
Sbjct: 296 QNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLS 355
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVD 753
+ E++ T I I D D G N V S+ F L + LV
Sbjct: 356 LPVREDAQPSTVIALISVSDRDSGVNGQVTCSL---TPHVPFKL-VSTFKNYYSLVLDSA 411
Query: 754 LDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPV 810
LD E+ YELV+ A SP LW RV + V DVNDNAP + ++ P
Sbjct: 412 LDRENV-WAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 470
Query: 811 GPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPKLA 863
V A DAD + + Y ++ G+ A + + ++ +G + L+ +L
Sbjct: 471 CHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELL 530
Query: 864 TMEVSVTD-GVNEIKAMMQLSVRLITE 889
+VS D GV + + + L V ++ E
Sbjct: 531 QFQVSARDAGVPPLSSNVTLQVFVLDE 557
Score = 103 bits (248), Expect = 7e-21
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 26/328 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVSEEAKHGTFVGRIA---QDLGLELA---ELVQRLFRVASKTHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V + V D+NDN PVF + I E
Sbjct: 88 SRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDINDNPPVFSLREQKLLIAESKQ 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG------VIRTNKALDRES 649
+ GA+DAD+ N + Y L + E + P +G + K+LDRE
Sbjct: 148 SDSRFPLEGASDADIEENALLTYRL---SKNEYFSLDSPTNGKQIKRLSLILKKSLDREK 204
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
+L A DGG P + TV + +++ D+ND+ P F+ + EN+ T + ++
Sbjct: 205 TPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKL 264
Query: 710 RAHDPDEGPNAVVHYSIKG--GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI 767
A D DEG N V YS+ + + F+L+ G E+ LDYE K Y++ +
Sbjct: 265 NATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNG----EVRVNGTLDYEE-NKFYKIEV 319
Query: 768 RA---ASPPLWNDVRVEILVTDVNDNAP 792
+A +PP+ V + + D NDN+P
Sbjct: 320 QATDKGTPPMAGHCTVWVEILDTNDNSP 347
>AF152506-1|AAD43767.1| 820|Homo sapiens protocadherin gamma A12
short form protein protein.
Length = 820
Score = 228 bits (558), Expect = 2e-58
Identities = 186/607 (30%), Positives = 277/607 (45%), Gaps = 30/607 (4%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + + + D++ + V + D NDN P
Sbjct: 74 LFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDIL-MEDKVKIYG-VEVEVRDINDNAP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSID----- 203
F E + + E+ + + A D D+G NS Y + NT +
Sbjct: 132 YFRESELEIKISENAATEMRFPLPH--AWDPDIGKNSLQSYEL-SPNTHFSLIVQNGADG 188
Query: 204 SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
S ++ L + LD E+ ++ LV+ A DGG P R+ T ++ + + D NDNAP F ++
Sbjct: 189 SKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYR 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
SV EN+ +G ++ V A D DEGVNAE+ Y+ D +D SG + T G+
Sbjct: 249 ASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVD--DKAAQVFKLDCNSGTISTIGE 306
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E YQ+ V A D SA A + + E+ P GT
Sbjct: 307 LDHEESGFYQMEVQAMDNAG--YSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGT 364
Query: 384 PVVTLTATDAD-EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
+ L D D E+N GN + + N L+T LD +Q Y +TV+
Sbjct: 365 LIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDI-VLDREQVPSYNITVT 423
Query: 443 ATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S + +N+ D N+ PVF A Y+A + E+ P G +++ V+A D D
Sbjct: 424 ATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEE 483
Query: 501 NAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
NAQITYSL+ A IN TG + D E + V ARD G P
Sbjct: 484 NAQITYSLAENTIQGASL--SSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPP 541
Query: 561 LSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLN 613
LS + + V+D NDN P + L T A G V++V A D D G N
Sbjct: 542 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSSTVI 672
+ Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+TV
Sbjct: 602 AWLSYRL-LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSATVT 659
Query: 673 VHIKIED 679
+ + + D
Sbjct: 660 LTVAVAD 666
Score = 188 bits (459), Expect = 2e-46
Identities = 169/585 (28%), Positives = 261/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND++P F + E + E A++ A D DIGKN+ Y + T +
Sbjct: 120 EVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFS 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L ++ DG + L+ + +LDRE+ A + +++ A+D PV
Sbjct: 180 LIVQNGA----------------DGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ TA I V ++D NDN P F++ Y SV E++++ ++ + ATD D G N+ +R
Sbjct: 223 --TGTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLV--VNATDPDEGVNAEVR 278
Query: 189 YAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ + F +D SG +S + LD+E+ Y++ ++A D + S ++LI
Sbjct: 279 YSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMD--NAGYSARAKVLIT 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDNAP + SV EN P G I + D D N ++ + GN
Sbjct: 337 VLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDSEENGQVICFI-----QGN-- 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ G Y T LDRE Y + VTATD G PP S
Sbjct: 390 LPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G +V++TA D D E+ ++ Y + +G S S N
Sbjct: 450 PVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINS 509
Query: 420 -RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAP--VFENAPY 474
G++ D++Q R + V A D+G S + + + D N+ AP ++ P
Sbjct: 510 DTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPT 569
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 570 DGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK-------ASEPGLFSVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 186 bits (454), Expect = 8e-46
Identities = 166/601 (27%), Positives = 279/601 (46%), Gaps = 42/601 (6%)
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTAT-DGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE + D + F
Sbjct: 77 LNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRES 136
Query: 370 QYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRG-----L 422
+ E++++E+ A D D +++ YE++ NT FS+ QNG
Sbjct: 137 ELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSP-NTH--FSLIVQNGADGSKYPE 193
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +++ + L ++A+D G R+ TA +++ + DAN+ AP F Y ASV E
Sbjct: 194 LVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ +GT +LVV+ATD D G+NA++ YS + ++A Q F ++ +G I+T LD
Sbjct: 254 NLALGTQLLVVNATDPDEGVNAEVRYSFRY-VDDKAA----QVFKLDCNSGTISTIGELD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A D S V I+V+DVNDN P +++ E++ GT +
Sbjct: 309 HEESGFYQMEVQAMDNA--GYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLI 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ + D D NG++ + + F ++ + G + T+ LDRE V ++++
Sbjct: 367 ALLNVNDQDSEENGQVICFI----QGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITV 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP S+ + + + D ND+PPVF + YI EN+P G ++ + AHDPD
Sbjct: 423 TATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCE 482
Query: 718 PNAVVHYSI-KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPPL 774
NA + YS+ + S S SD L + DYE R + +++ R PPL
Sbjct: 483 ENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPL 542
Query: 775 WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------DADVT 824
++V + + V D NDNAP + + + + + P P Y D+
Sbjct: 543 SSNVSLSLFVLDQNDNAPEIL-YPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601
Query: 825 DKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLS 883
L YR+L + L + TG + + L ++ V+V D G + A + L+
Sbjct: 602 AWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLT 661
Query: 884 V 884
V
Sbjct: 662 V 662
Score = 168 bits (409), Expect = 2e-40
Identities = 139/472 (29%), Positives = 211/472 (44%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD ND++P F +Y ASV E + GT +L + ATD D G NAEV Y+ V
Sbjct: 229 RVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYV---- 284
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D VF++D SG + T LD E+ Y + V+A D A
Sbjct: 285 ---DDKAA----------QVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAG----- 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S+ A + + ++D NDN P+ + SV E + +IA + D D N +
Sbjct: 327 YSARAKVLITVLDVNDNAPEVVLTSLASSVPE--NSPRGTLIALLNVNDQDSEENGQV-I 383
Query: 190 AIIGGNTQMQFSIDSLSGD-VSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I GN + F ++ G+ SLV LD EQV SY + + A D G+P S T + +N
Sbjct: 384 CFIQGN--LPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLN 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ D NDN P F + + + EN P G S+V V A+D D NA++TY++ + G ++
Sbjct: 442 VADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E Q+ V A D G PP S+ +
Sbjct: 502 SSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPE 561
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G VELA PG V + A D D L Y + + G FS+
Sbjct: 562 ILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A++ V
Sbjct: 622 HTGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQV 671
Score = 124 bits (300), Expect = 3e-27
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 16/280 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETM-SGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP++G++ T +DRE + G + D + VE+ V D+NDN P
Sbjct: 73 QLFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPY 132
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--- 637
F++ I E+A A D D+G N YEL P + V + A G
Sbjct: 133 FRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSP-NTHFSLIVQNGADGSKY 191
Query: 638 -VIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYI 696
+ +ALDRE A H L A DGG P ++ T + + + D ND+ P F +
Sbjct: 192 PELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASV 251
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDL 754
EN +GT + + A DPDEG NA V YS + DD + F L+ G+ + T+ +L
Sbjct: 252 PENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGT----ISTIGEL 307
Query: 755 DYESPRKKYELVIRAASPPLWNDVRVEILVT--DVNDNAP 792
D+E Y++ ++A ++ R ++L+T DVNDNAP
Sbjct: 308 DHEE-SGFYQMEVQAMDNAGYS-ARAKVLITVLDVNDNAP 345
Score = 84.2 bits (199), Expect = 6e-15
Identities = 62/247 (25%), Positives = 104/247 (42%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H +NV D ND+ PVF Y A + E G +++++ A D D +NA++ Y++
Sbjct: 437 HISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSL---AE 493
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+T+ + I+ +G L +S D E+ V V A D P
Sbjct: 494 NTIQ-----------GASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHP-- 540
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDI-----SVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN P+ + S ++ K+ A D D G
Sbjct: 541 -PLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG 599
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ + FS+ +G+V + L LV+ QD G P S T
Sbjct: 600 QNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT 659
Query: 243 LLINIRD 249
L + + D
Sbjct: 660 LTVAVAD 666
Score = 72.5 bits (170), Expect = 2e-11
Identities = 62/203 (30%), Positives = 95/203 (46%), Gaps = 16/203 (7%)
Query: 601 SQVGATDADVGLNGRIHYE----LDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
S+VG D+GL R E + P+ R + F ++P SG + T +DRE + +K
Sbjct: 43 SRVGDISRDLGLEPRELAERGVRIIPRGRTQ-LFALNPRSGSLVTAGRIDREELCMGAIK 101
Query: 657 A-VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+ +D + V +++ DIND+ P F L ISEN+ A DPD
Sbjct: 102 CQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPD 161
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKYELVIRAA-- 770
G N++ Y + + FSL + G+D + ELV LD E + + LV+ A+
Sbjct: 162 IGKNSLQSYEL---SPNTHFSLIVQNGADGSKYPELVLKRALDREE-KAAHHLVLTASDG 217
Query: 771 -SPPLWNDVRVEILVTDVNDNAP 792
P R+ ++V D NDNAP
Sbjct: 218 GDPVRTGTARIRVMVLDANDNAP 240
>AF152483-1|AAD43744.1| 816|Homo sapiens protocadherin alpha 5
short form protein protein.
Length = 816
Score = 228 bits (558), Expect = 2e-58
Identities = 171/617 (27%), Positives = 283/617 (45%), Gaps = 33/617 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ R + + + DR + V + D NDN
Sbjct: 72 DLLEVNLQNGILFVNSRIDREELCRRRA--ECSIHLEVIVDRPLQVFHVEVAVKDINDNP 129
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P+FS + + + E + D+ + A+D D+GAN+ +RY + N F +D +
Sbjct: 130 PRFSRQEQRLFILES-RMPDSRFPLE-GASDLDIGANAQLRYRL---NPNEYFDLDVKTN 184
Query: 208 D-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
+ + L K+LD E+ + +RL++ A DGG P + T QLLIN+ D NDNAP F S
Sbjct: 185 EEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKS 244
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
++ + EN P G ++++ A DADEG+N E+ Y ++ +V I+ +G +
Sbjct: 245 IYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNL-VLDDVKSKFIINSNTGEIKV 303
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
+G+LD E Y++ + A D P S + + ED P
Sbjct: 304 NGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAP 363
Query: 381 PGTPVVTLTATDADEDNRLHYEITGG---NTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T + ++ +D D+ + ++T + + T +N L+ + LD + Y
Sbjct: 364 LSTVIALISV--SDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESVSVY 420
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D
Sbjct: 421 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARD 480
Query: 496 SDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
+D NA ++YSL E ++ ++G + + LD E + V+ARD
Sbjct: 481 ADAQENALVSYSLVERRVGERPL--SSYVSVHAESGKVYALQPLDHEEVELLQFQVSARD 538
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDA 608
GVP L +++ V+D NDN P T + + + G V++V A D
Sbjct: 539 AGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDP 598
Query: 609 DVGLNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
D G N + YEL P F + +G I T ++LD H L + D G PP
Sbjct: 599 DSGYNAWLSYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPL 658
Query: 668 SSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 659 TATATVLVSLVESGQAP 675
Score = 214 bits (523), Expect = 3e-54
Identities = 165/553 (29%), Positives = 249/553 (45%), Gaps = 37/553 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN PRF + + E+ A D D G NA+L Y + +Y
Sbjct: 120 VAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEY--- 176
Query: 305 VDLPI-TIDPRSGWV--YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
DL + T + + ++ LDRE +++LLV ATDGG P + T
Sbjct: 177 FDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDAND 236
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSITS 416
F Y V L E+ P GT V+ L A+DADE + + Y + + + +F I S
Sbjct: 237 NAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINS 296
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPY 474
G I V LD++ Y + + A D S V + + D N+ P
Sbjct: 297 NTGE--IKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTL 354
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
V EDAP+ T + ++S +D D G N Q+T SL + + V+ + ++
Sbjct: 355 FLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLV 407
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 408 LDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENN 467
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESV 650
G + V A DAD N + Y L + +R S+V + SG + + LD E V
Sbjct: 468 PPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEV 527
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIG 703
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 528 ELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAG 587
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKK 762
+ ++RA DPD G NA + Y ++ S + R G E+ T LD E+PR +
Sbjct: 588 HVVAKVRAVDPDSGYNAWLSYELQPA--PGSARIPFRVGLYTGEISTTRSLDETEAPRHR 645
Query: 763 YELVIR-AASPPL 774
++++ PPL
Sbjct: 646 LLVLVKDHGEPPL 658
Score = 200 bits (489), Expect = 4e-50
Identities = 163/584 (27%), Positives = 258/584 (44%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ P F Q+ + E + A+D DIG NA++ Y
Sbjct: 117 HVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRY------- 169
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
LNP + + L+ R SLDRE+ + +LV ATD P
Sbjct: 170 -RLNPNEYFDLDVKTNEEETNFLE-------LVLRKSLDREETQEHRLLVIATDGGKP-- 219
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + +N++D NDN P+F + Y V + E + ++ K+ A+DAD G N I
Sbjct: 220 -ELTGTVQLLINVLDANDNAPEFDKSIYNVRLLE--NAPSGTLVIKLNASDADEGINKEI 276
Query: 188 RY---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y ++ + + +F I+S +G++ + LDYE SY + I A D + S +++
Sbjct: 277 VYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVV 336
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDN P + V E+ P+ I + D D G N ++T ++ +
Sbjct: 337 VKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP-----H 391
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNG 419
F QY V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHA 511
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 512 ESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGG 571
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ V G V V A D D G NA ++Y L + + F +
Sbjct: 572 TGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARI-----PFRVGLY 626
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G P L+ T V +S+V+
Sbjct: 627 TGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLVE 670
Score = 192 bits (469), Expect = 1e-47
Identities = 119/377 (31%), Positives = 196/377 (51%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQ--INITDANNYAPVFENAPYTASVFE 480
+ + + LD ++ + + L V ATD G T VQ IN+ DAN+ AP F+ + Y + E
Sbjct: 193 LVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP GT V+ ++A+D+D GIN +I Y S+ + ++ + +F+IN TG I N LD
Sbjct: 253 NAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKS----KFIINSNTGEIKVNGELD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A D LS V + ++DVNDN P + EDA + T +
Sbjct: 309 YEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVI 368
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 ALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESVSVYELVVTAR 427
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 428 DGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENA 487
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPR-KKYELVIR-AASPPLWND 777
+V YS ++ S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 488 LVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSN 547
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 548 VTLQVFVLDENDNAPAL 564
Score = 57.2 bits (132), Expect = 8e-07
Identities = 67/281 (23%), Positives = 123/281 (43%), Gaps = 18/281 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
+I E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 33 SIPEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDR 91
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V + ++DIND+PP F +I E+ +
Sbjct: 92 EELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRF 151
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKY 763
A D D G NA + Y + + + F L+ + ++ ELV LD E ++
Sbjct: 152 PLEGASDLDIGANAQLRYRL---NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHR 208
Query: 764 ELVIR--AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG-RVPAYD 820
LVI P L V++ I V D NDNAP D I + P G ++ A D
Sbjct: 209 LLVIATDGGKPELTGTVQLLINVLDANDNAPEF-DKSIYNVRLLENAPSGTLVIKLNASD 267
Query: 821 AD--VTDKLQY---RILSGNNANLILLNETTGSMTLSPQLN 856
AD + ++ Y ++ + + ++N TG + ++ +L+
Sbjct: 268 ADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELD 308
>AF152476-1|AAD43737.1| 810|Homo sapiens protocadherin alpha 11
short form protein protein.
Length = 810
Score = 228 bits (558), Expect = 2e-58
Identities = 179/618 (28%), Positives = 291/618 (47%), Gaps = 36/618 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR ++V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGQSA--ECSIHLEVIVDRPLQVFHVNVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P FS + + + E S + A+DAD+ N+ + Y + + FS+DS +
Sbjct: 131 PVFSLREQKLLIAE--SKQSDSRFPLEGASDADIEENALLTYRL---SKNEYFSLDSPTN 185
Query: 208 D-----VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
+SL+ K+LD E+ L++ A DGG P + T +LL+ + DVNDN P F S
Sbjct: 186 GKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKS 245
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
++ S+ EN ++++ A D DEGVN E+TY++ G T+D +G V
Sbjct: 246 EYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR--HLFTLDQNNGEVRV 303
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
+G LD E Y++ V ATD G PP + T + + ED
Sbjct: 304 NGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQ 363
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRY 437
P T + ++ +D D+ ++ ++T T F + S +N L+ + LD + Y
Sbjct: 364 PSTVIALISV--SDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRENVWAY 420
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D
Sbjct: 421 ELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD 480
Query: 496 SDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
+D NA ++YSL + + A++ + ++ ++G + + LD E + V+AR
Sbjct: 481 ADAQENALVSYSLVERRLGDRALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSAR 537
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATD 607
D GVP LS +++ V+D NDN P + Q +A + LV G V++V A D
Sbjct: 538 DAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVD 597
Query: 608 ADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
AD G N + YEL P F + +G I T +ALD H L + D G P
Sbjct: 598 ADSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPA 657
Query: 667 QSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 658 LTATATVLVSLVESGQAP 675
Score = 211 bits (516), Expect = 2e-53
Identities = 174/609 (28%), Positives = 271/609 (44%), Gaps = 45/609 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF +++ + + E S + A+D DI +NA + Y +
Sbjct: 118 HVNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+L+ + + R+ +L+ + SLDREK +L+ ATD P
Sbjct: 178 FSLDSPTNG----------KQIKRL-----SLILKKSLDREKTPELNLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + V ++D NDN P+F + Y VS+ E+ + ++ K+ ATD D G N +
Sbjct: 221 -ELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAA--KETLVLKLNATDRDEGVNGEV 277
Query: 188 RYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y++ I N + F++D +G+V + TLDYE+ + Y++ ++A D G+P + + +
Sbjct: 278 TYSLMSIKPNGRHLFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWV 337
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D NDN+P + V E+ I + D D GVN ++T ++T
Sbjct: 338 EILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHV---PF 394
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
L T V S LDRE Y+L+VTA DGG P ATA
Sbjct: 395 KLVSTFKNYYSLVLDSA-LDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPA 453
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR- 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 454 FAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAES 513
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF-------EN 471
G + QPLD ++ VSA D+G S +Q+ + D N+ AP
Sbjct: 514 GKVYALQPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAG 573
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
V G V V A D+D G NA ++Y L + F + TG
Sbjct: 574 GAVNKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIP-----FRVGLYTG 628
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 629 EISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRTLAGAASP 688
Query: 592 EDALVGTSV 600
E ALV +V
Sbjct: 689 EAALVDVNV 697
Score = 210 bits (513), Expect = 5e-53
Identities = 159/546 (29%), Positives = 244/546 (44%), Gaps = 27/546 (4%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ A DAD NA LTY ++ +Y +
Sbjct: 121 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYF-S 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D P + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDND 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F +Y+V L E+ T V+ L ATD DE + + Y + GR T G
Sbjct: 240 PEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNG 299
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ V LD+++ + Y + V ATD G + V + I D N+ +P + V
Sbjct: 300 EVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVR 359
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
EDA T + ++S +D D G+N Q+T SL+ + + V+ + ++ + L
Sbjct: 360 EDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYY-------SLVLDSAL 412
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
DRE + Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 413 DRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCH 472
Query: 600 VSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATHDL 655
+ V A DAD N + Y L + DR S+V + SG + + LD E +
Sbjct: 473 IFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQF 532
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGE 708
+ A D G PP SS V + + + D ND+ P + + + G + +
Sbjct: 533 QVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAK 592
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYELVI 767
+RA D D G NA + Y ++ + + R G E+ T LD +SPR + +++
Sbjct: 593 VRAVDADSGYNAWLSYELQPA--AGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLV 650
Query: 768 RAASPP 773
+ P
Sbjct: 651 KDHGEP 656
Score = 177 bits (431), Expect = 5e-43
Identities = 127/415 (30%), Positives = 206/415 (49%), Gaps = 17/415 (4%)
Query: 390 ATDAD-EDNRL-HYEITGGNTRGRFSITS--QNGRGLITVAQPLDFKQERRYVLTVSATD 445
A+DAD E+N L Y ++ S T+ Q R + + + LD ++ L ++ATD
Sbjct: 157 ASDADIEENALLTYRLSKNEYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATD 216
Query: 446 SGGRSDTAMVQ--INITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T V+ + + D N+ P F+ + Y S+ E+A T VL ++ATD D G+N +
Sbjct: 217 GGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGE 276
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
+TYSL S N H F ++ G + N LD E Y + V A D G P ++
Sbjct: 277 VTYSLMSIKPN---GRH--LFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAG 331
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
V + ++D NDN P + + EDA T ++ + +D D G+NG++ L P
Sbjct: 332 HCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPH 391
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
+ ++ + ALDRE+V ++L A DGG+P +T V +++ D+ND+
Sbjct: 392 VPFKLVSTFKNYYSLV-LDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDN 450
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI---KGGDDSNSFSLETR 740
P F T ++ EN+P G I + A D D NA+V YS+ + GD + S +
Sbjct: 451 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVH 510
Query: 741 QGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVRVEILVTDVNDNAPVM 794
S K + +D + E ++++ R A PPL ++V +++ V D NDNAP +
Sbjct: 511 AESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPAL 564
Score = 157 bits (382), Expect = 4e-37
Identities = 133/447 (29%), Positives = 202/447 (45%), Gaps = 20/447 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + + D N+ PVF + E + + A+D+D+ NA +TY LS N
Sbjct: 119 VNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSK---N 175
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
E + + ++ K LDRE L +TA DGG P L+ T + + V+DV
Sbjct: 176 EYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDV 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL-DPKDREEGSFVID 633
NDN+P F + Y ++ME+A T V ++ ATD D G+NG + Y L K F +D
Sbjct: 236 NDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLD 295
Query: 634 PASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+G +R N LD E + ++ A D GTPP + V ++I D ND+ P L+
Sbjct: 296 QNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLS 355
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVD 753
+ E++ T I I D D G N V S+ F L + LV
Sbjct: 356 LPVREDAQPSTVIALISVSDRDSGVNGQVTCSL---TPHVPFKL-VSTFKNYYSLVLDSA 411
Query: 754 LDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPV 810
LD E+ YELV+ A SP LW RV + V DVNDNAP + ++ P
Sbjct: 412 LDRENV-WAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 470
Query: 811 GPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPKLA 863
V A DAD + + Y ++ G+ A + + ++ +G + L+ +L
Sbjct: 471 CHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELL 530
Query: 864 TMEVSVTD-GVNEIKAMMQLSVRLITE 889
+VS D GV + + + L V ++ E
Sbjct: 531 QFQVSARDAGVPPLSSNVTLQVFVLDE 557
Score = 103 bits (248), Expect = 7e-21
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 26/328 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVSEEAKHGTFVGRIA---QDLGLELA---ELVQRLFRVASKTHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V + V D+NDN PVF + I E
Sbjct: 88 SRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDINDNPPVFSLREQKLLIAESKQ 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG------VIRTNKALDRES 649
+ GA+DAD+ N + Y L + E + P +G + K+LDRE
Sbjct: 148 SDSRFPLEGASDADIEENALLTYRL---SKNEYFSLDSPTNGKQIKRLSLILKKSLDREK 204
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
+L A DGG P + TV + +++ D+ND+ P F+ + EN+ T + ++
Sbjct: 205 TPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKL 264
Query: 710 RAHDPDEGPNAVVHYSIKG--GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI 767
A D DEG N V YS+ + + F+L+ G E+ LDYE K Y++ +
Sbjct: 265 NATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNG----EVRVNGTLDYEE-NKFYKIEV 319
Query: 768 RA---ASPPLWNDVRVEILVTDVNDNAP 792
+A +PP+ V + + D NDN+P
Sbjct: 320 QATDKGTPPMAGHCTVWVEILDTNDNSP 347
>AF152474-1|AAD43735.1| 884|Homo sapiens protocadherin alpha C2
short form protein protein.
Length = 884
Score = 228 bits (558), Expect = 2e-58
Identities = 173/584 (29%), Positives = 266/584 (45%), Gaps = 56/584 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ +LD ND+SP F Y+ V E + G A D D+G N+ Y
Sbjct: 135 EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTY--------E 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
L+P + V L+ R LDRE+ A + +++ A D P
Sbjct: 187 LSPSEHFELDLKPLQENSKVLE-------LVLRKGLDREQAALHHLVLTAVDGGIPAR-- 237
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S TA I V ++D NDN P F + TY V + ED ++ K+ A+D D G+N +RY
Sbjct: 238 -SGTAQISVRVLDTNDNSPAFDQSTYRVQLRED--SPPGTLVVKLNASDPDEGSNGELRY 294
Query: 190 AIIGGNTQMQ---FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++ + + FSID+ +G+V ++ LDYE+ SY++ ++A D G + ++L++
Sbjct: 295 SLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVD 354
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I DVNDNAP + V EN + + D D G N +++ +
Sbjct: 355 IVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-------EAT 407
Query: 307 LPITID--PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
LP ++ S + SG LDRE A Y + VTATDGG P ++ T
Sbjct: 408 LPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPP 467
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR-------LHYEITGGNTRGRFSITSQ 417
F+ Y + + E+ PG + T+ ATD DE L EI G SI S
Sbjct: 468 SFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSA 527
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAP 473
+G + D+++ R + +TV A D G S T + + D N++AP ++ +
Sbjct: 528 SGS--LYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTST 585
Query: 474 YTASVFE----DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++ FE AP G V V A DSD G NA + Y L+ + F +
Sbjct: 586 NSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDL-------FKVELH 638
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I T + + E+ S + LTV RD G PSLS + + ++VVD
Sbjct: 639 TGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682
Score = 228 bits (557), Expect = 3e-58
Identities = 177/603 (29%), Positives = 275/603 (45%), Gaps = 27/603 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D SGAL +DRE + + ++ + + + V I+D NDN P+F
Sbjct: 92 LDLTSGALFVNERIDREALCEQRP--RCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG---- 207
Y + V E SV A D DVGANS Y + + + + L
Sbjct: 150 RPNYQLQVSE--SVAPGARFHIESAQDPDVGANSVQTYEL-SPSEHFELDLKPLQENSKV 206
Query: 208 -DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD EQ + LV+ A DGG P+RS T Q+ + + D NDN+P F S ++ +
Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQL 266
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLD 325
E+ P G +V++ A D DEG N EL Y+++ YT + + + +ID +G V G LD
Sbjct: 267 REDSPPGTLVVKLNASDPDEGSNGELRYSLS--SYTSDRERQLFSIDASTGEVRVIGGLD 324
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E + YQ+ V ATD G P + + + E+ P T V
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIV 384
Query: 386 VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATD 445
L+ D D + G F + + V+ PLD ++ Y +TV+ATD
Sbjct: 385 AVLSVNDQDSGPNRKVSL-GLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATD 443
Query: 446 SGGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T++ +++ I+D N+ P F Y+ + E+ G + V ATD D NA+
Sbjct: 444 GGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAE 503
Query: 504 ITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
+TYS L EI V + IN +G++ D E + +TV A+D G P LS
Sbjct: 504 VTYSLLEREIQGLPVTSY---VSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLS 560
Query: 563 DTTDVEISVVDVNDNEPVFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLNGRI 616
T + VVD+ND+ P T + + A G V++V A D+D G N +
Sbjct: 561 STVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWL 620
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
Y L + + F ++ +G IRT + + ES +T +L V D G P S++V + +
Sbjct: 621 FYHL-AQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVA 679
Query: 677 IED 679
+ D
Sbjct: 680 VVD 682
Score = 183 bits (446), Expect = 7e-45
Identities = 166/604 (27%), Positives = 279/604 (46%), Gaps = 37/604 (6%)
Query: 309 ITIDPRSGWVYTSGQLDRET--QAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+ +D SG ++ + ++DRE + + + L++ P + +A
Sbjct: 90 LELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGG-NTRGRFSITSQNGRGL- 422
P Y+++++E PG +A D D N + YE++ + +N + L
Sbjct: 150 RPN-YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLE 208
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +Q + L ++A D G RS TA + + + D N+ +P F+ + Y + E
Sbjct: 209 LVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLRE 268
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
D+P GT V+ ++A+D D G N ++ YSLSS S+ Q F I+ TG + LD
Sbjct: 269 DSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDR----ERQLFSIDASTGEVRVIGGLD 324
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALVGTS 599
E S Y + V A D G ++ V + +VDVNDN P V LY+ + E+A T
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP-VPENATPNTI 383
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
V+ + D D G N ++ L+ + + + V+ + LDRE VA +++ A
Sbjct: 384 VAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVV--SGPLDRERVAVYNITVTA 441
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG P +S + ++I DIND+PP F D + YI EN+ G + ++A DPDE N
Sbjct: 442 TDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKEN 501
Query: 720 AVVHYS-----IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR--AASP 772
A V YS I+G ++ S+ + GS L + DYE R+ + V SP
Sbjct: 502 AEVTYSLLEREIQGLPVTSYVSINSASGS----LYAVNSFDYEKFREFFVTVEAQDKGSP 557
Query: 773 PLWNDVRVEILVTDVNDNA-----PVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
PL + V + V D+ND+A P + F P G +V A D+D
Sbjct: 558 PLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQN 617
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLS 883
L Y + ++ +L + TG + + ++ + V V D G + A + ++
Sbjct: 618 AWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAIT 677
Query: 884 VRLI 887
V ++
Sbjct: 678 VAVV 681
>AF152321-1|AAD43715.1| 932|Homo sapiens protocadherin gamma A12
protein.
Length = 932
Score = 228 bits (558), Expect = 2e-58
Identities = 186/607 (30%), Positives = 277/607 (45%), Gaps = 30/607 (4%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + + + D++ + V + D NDN P
Sbjct: 74 LFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDIL-MEDKVKIYG-VEVEVRDINDNAP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSID----- 203
F E + + E+ + + A D D+G NS Y + NT +
Sbjct: 132 YFRESELEIKISENAATEMRFPLPH--AWDPDIGKNSLQSYEL-SPNTHFSLIVQNGADG 188
Query: 204 SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
S ++ L + LD E+ ++ LV+ A DGG P R+ T ++ + + D NDNAP F ++
Sbjct: 189 SKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYR 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
SV EN+ +G ++ V A D DEGVNAE+ Y+ D +D SG + T G+
Sbjct: 249 ASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVD--DKAAQVFKLDCNSGTISTIGE 306
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E YQ+ V A D SA A + + E+ P GT
Sbjct: 307 LDHEESGFYQMEVQAMDNAG--YSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGT 364
Query: 384 PVVTLTATDAD-EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
+ L D D E+N GN + + N L+T LD +Q Y +TV+
Sbjct: 365 LIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDI-VLDREQVPSYNITVT 423
Query: 443 ATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S + +N+ D N+ PVF A Y+A + E+ P G +++ V+A D D
Sbjct: 424 ATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEE 483
Query: 501 NAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
NAQITYSL+ A IN TG + D E + V ARD G P
Sbjct: 484 NAQITYSLAENTIQGASL--SSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPP 541
Query: 561 LSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLN 613
LS + + V+D NDN P + L T A G V++V A D D G N
Sbjct: 542 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSSTVI 672
+ Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+TV
Sbjct: 602 AWLSYRL-LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSATVT 659
Query: 673 VHIKIED 679
+ + + D
Sbjct: 660 LTVAVAD 666
Score = 188 bits (459), Expect = 2e-46
Identities = 169/585 (28%), Positives = 261/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND++P F + E + E A++ A D DIGKN+ Y + T +
Sbjct: 120 EVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFS 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L ++ DG + L+ + +LDRE+ A + +++ A+D PV
Sbjct: 180 LIVQNGA----------------DGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ TA I V ++D NDN P F++ Y SV E++++ ++ + ATD D G N+ +R
Sbjct: 223 --TGTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLV--VNATDPDEGVNAEVR 278
Query: 189 YAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ + F +D SG +S + LD+E+ Y++ ++A D + S ++LI
Sbjct: 279 YSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMD--NAGYSARAKVLIT 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDNAP + SV EN P G I + D D N ++ + GN
Sbjct: 337 VLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDSEENGQVICFI-----QGN-- 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ G Y T LDRE Y + VTATD G PP S
Sbjct: 390 LPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G +V++TA D D E+ ++ Y + +G S S N
Sbjct: 450 PVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINS 509
Query: 420 -RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAP--VFENAPY 474
G++ D++Q R + V A D+G S + + + D N+ AP ++ P
Sbjct: 510 DTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPT 569
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 570 DGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK-------ASEPGLFSVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 186 bits (454), Expect = 8e-46
Identities = 166/601 (27%), Positives = 279/601 (46%), Gaps = 42/601 (6%)
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTAT-DGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE + D + F
Sbjct: 77 LNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRES 136
Query: 370 QYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRG-----L 422
+ E++++E+ A D D +++ YE++ NT FS+ QNG
Sbjct: 137 ELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSP-NTH--FSLIVQNGADGSKYPE 193
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +++ + L ++A+D G R+ TA +++ + DAN+ AP F Y ASV E
Sbjct: 194 LVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ +GT +LVV+ATD D G+NA++ YS + ++A Q F ++ +G I+T LD
Sbjct: 254 NLALGTQLLVVNATDPDEGVNAEVRYSFRY-VDDKAA----QVFKLDCNSGTISTIGELD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A D S V I+V+DVNDN P +++ E++ GT +
Sbjct: 309 HEESGFYQMEVQAMDNA--GYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLI 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ + D D NG++ + + F ++ + G + T+ LDRE V ++++
Sbjct: 367 ALLNVNDQDSEENGQVICFI----QGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITV 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP S+ + + + D ND+PPVF + YI EN+P G ++ + AHDPD
Sbjct: 423 TATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCE 482
Query: 718 PNAVVHYSI-KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPPL 774
NA + YS+ + S S SD L + DYE R + +++ R PPL
Sbjct: 483 ENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPL 542
Query: 775 WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------DADVT 824
++V + + V D NDNAP + + + + + P P Y D+
Sbjct: 543 SSNVSLSLFVLDQNDNAPEIL-YPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601
Query: 825 DKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLS 883
L YR+L + L + TG + + L ++ V+V D G + A + L+
Sbjct: 602 AWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLT 661
Query: 884 V 884
V
Sbjct: 662 V 662
Score = 168 bits (409), Expect = 2e-40
Identities = 139/472 (29%), Positives = 211/472 (44%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD ND++P F +Y ASV E + GT +L + ATD D G NAEV Y+ V
Sbjct: 229 RVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYV---- 284
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D VF++D SG + T LD E+ Y + V+A D A
Sbjct: 285 ---DDKAA----------QVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAG----- 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S+ A + + ++D NDN P+ + SV E + +IA + D D N +
Sbjct: 327 YSARAKVLITVLDVNDNAPEVVLTSLASSVPE--NSPRGTLIALLNVNDQDSEENGQV-I 383
Query: 190 AIIGGNTQMQFSIDSLSGD-VSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I GN + F ++ G+ SLV LD EQV SY + + A D G+P S T + +N
Sbjct: 384 CFIQGN--LPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLN 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ D NDN P F + + + EN P G S+V V A+D D NA++TY++ + G ++
Sbjct: 442 VADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASL 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E Q+ V A D G PP S+ +
Sbjct: 502 SSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPE 561
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G VELA PG V + A D D L Y + + G FS+
Sbjct: 562 ILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A++ V
Sbjct: 622 HTGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQV 671
Score = 124 bits (300), Expect = 3e-27
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 16/280 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETM-SGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP++G++ T +DRE + G + D + VE+ V D+NDN P
Sbjct: 73 QLFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPY 132
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--- 637
F++ I E+A A D D+G N YEL P + V + A G
Sbjct: 133 FRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSP-NTHFSLIVQNGADGSKY 191
Query: 638 -VIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYI 696
+ +ALDRE A H L A DGG P ++ T + + + D ND+ P F +
Sbjct: 192 PELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASV 251
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDL 754
EN +GT + + A DPDEG NA V YS + DD + F L+ G+ + T+ +L
Sbjct: 252 PENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGT----ISTIGEL 307
Query: 755 DYESPRKKYELVIRAASPPLWNDVRVEILVT--DVNDNAP 792
D+E Y++ ++A ++ R ++L+T DVNDNAP
Sbjct: 308 DHEE-SGFYQMEVQAMDNAGYS-ARAKVLITVLDVNDNAP 345
Score = 84.2 bits (199), Expect = 6e-15
Identities = 62/247 (25%), Positives = 104/247 (42%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H +NV D ND+ PVF Y A + E G +++++ A D D +NA++ Y++
Sbjct: 437 HISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSL---AE 493
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+T+ + I+ +G L +S D E+ V V A D P
Sbjct: 494 NTIQ-----------GASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHP-- 540
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDI-----SVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN P+ + S ++ K+ A D D G
Sbjct: 541 -PLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG 599
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ + FS+ +G+V + L LV+ QD G P S T
Sbjct: 600 QNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT 659
Query: 243 LLINIRD 249
L + + D
Sbjct: 660 LTVAVAD 666
Score = 72.5 bits (170), Expect = 2e-11
Identities = 62/203 (30%), Positives = 95/203 (46%), Gaps = 16/203 (7%)
Query: 601 SQVGATDADVGLNGRIHYE----LDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
S+VG D+GL R E + P+ R + F ++P SG + T +DRE + +K
Sbjct: 43 SRVGDISRDLGLEPRELAERGVRIIPRGRTQ-LFALNPRSGSLVTAGRIDREELCMGAIK 101
Query: 657 A-VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+ +D + V +++ DIND+ P F L ISEN+ A DPD
Sbjct: 102 CQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPD 161
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKYELVIRAA-- 770
G N++ Y + + FSL + G+D + ELV LD E + + LV+ A+
Sbjct: 162 IGKNSLQSYEL---SPNTHFSLIVQNGADGSKYPELVLKRALDREE-KAAHHLVLTASDG 217
Query: 771 -SPPLWNDVRVEILVTDVNDNAP 792
P R+ ++V D NDNAP
Sbjct: 218 GDPVRTGTARIRVMVLDANDNAP 240
>AF152313-1|AAD43707.1| 936|Homo sapiens protocadherin alpha 5
protein.
Length = 936
Score = 228 bits (558), Expect = 2e-58
Identities = 171/617 (27%), Positives = 283/617 (45%), Gaps = 33/617 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ R + + + DR + V + D NDN
Sbjct: 72 DLLEVNLQNGILFVNSRIDREELCRRRA--ECSIHLEVIVDRPLQVFHVEVAVKDINDNP 129
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P+FS + + + E + D+ + A+D D+GAN+ +RY + N F +D +
Sbjct: 130 PRFSRQEQRLFILES-RMPDSRFPLE-GASDLDIGANAQLRYRL---NPNEYFDLDVKTN 184
Query: 208 D-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
+ + L K+LD E+ + +RL++ A DGG P + T QLLIN+ D NDNAP F S
Sbjct: 185 EEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKS 244
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
++ + EN P G ++++ A DADEG+N E+ Y ++ +V I+ +G +
Sbjct: 245 IYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNL-VLDDVKSKFIINSNTGEIKV 303
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
+G+LD E Y++ + A D P S + + ED P
Sbjct: 304 NGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAP 363
Query: 381 PGTPVVTLTATDADEDNRLHYEITGG---NTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T + ++ +D D+ + ++T + + T +N L+ + LD + Y
Sbjct: 364 LSTVIALISV--SDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESVSVY 420
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D
Sbjct: 421 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARD 480
Query: 496 SDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
+D NA ++YSL E ++ ++G + + LD E + V+ARD
Sbjct: 481 ADAQENALVSYSLVERRVGERPL--SSYVSVHAESGKVYALQPLDHEEVELLQFQVSARD 538
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDA 608
GVP L +++ V+D NDN P T + + + G V++V A D
Sbjct: 539 AGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDP 598
Query: 609 DVGLNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
D G N + YEL P F + +G I T ++LD H L + D G PP
Sbjct: 599 DSGYNAWLSYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPL 658
Query: 668 SSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 659 TATATVLVSLVESGQAP 675
Score = 214 bits (523), Expect = 3e-54
Identities = 165/553 (29%), Positives = 249/553 (45%), Gaps = 37/553 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN PRF + + E+ A D D G NA+L Y + +Y
Sbjct: 120 VAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEY--- 176
Query: 305 VDLPI-TIDPRSGWV--YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
DL + T + + ++ LDRE +++LLV ATDGG P + T
Sbjct: 177 FDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDAND 236
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSITS 416
F Y V L E+ P GT V+ L A+DADE + + Y + + + +F I S
Sbjct: 237 NAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINS 296
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPY 474
G I V LD++ Y + + A D S V + + D N+ P
Sbjct: 297 NTGE--IKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTL 354
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
V EDAP+ T + ++S +D D G N Q+T SL + + V+ + ++
Sbjct: 355 FLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLV 407
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 408 LDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENN 467
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESV 650
G + V A DAD N + Y L + +R S+V + SG + + LD E V
Sbjct: 468 PPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEV 527
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIG 703
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 528 ELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAG 587
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKK 762
+ ++RA DPD G NA + Y ++ S + R G E+ T LD E+PR +
Sbjct: 588 HVVAKVRAVDPDSGYNAWLSYELQPA--PGSARIPFRVGLYTGEISTTRSLDETEAPRHR 645
Query: 763 YELVIR-AASPPL 774
++++ PPL
Sbjct: 646 LLVLVKDHGEPPL 658
Score = 200 bits (489), Expect = 4e-50
Identities = 163/584 (27%), Positives = 258/584 (44%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ P F Q+ + E + A+D DIG NA++ Y
Sbjct: 117 HVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRY------- 169
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
LNP + + L+ R SLDRE+ + +LV ATD P
Sbjct: 170 -RLNPNEYFDLDVKTNEEETNFLE-------LVLRKSLDREETQEHRLLVIATDGGKP-- 219
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + +N++D NDN P+F + Y V + E + ++ K+ A+DAD G N I
Sbjct: 220 -ELTGTVQLLINVLDANDNAPEFDKSIYNVRLLE--NAPSGTLVIKLNASDADEGINKEI 276
Query: 188 RY---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y ++ + + +F I+S +G++ + LDYE SY + I A D + S +++
Sbjct: 277 VYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVV 336
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDN P + V E+ P+ I + D D G N ++T ++ +
Sbjct: 337 VKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP-----H 391
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNG 419
F QY V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHA 511
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 512 ESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGG 571
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ V G V V A D D G NA ++Y L + + F +
Sbjct: 572 TGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARI-----PFRVGLY 626
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G P L+ T V +S+V+
Sbjct: 627 TGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLVE 670
Score = 192 bits (469), Expect = 1e-47
Identities = 119/377 (31%), Positives = 196/377 (51%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQ--INITDANNYAPVFENAPYTASVFE 480
+ + + LD ++ + + L V ATD G T VQ IN+ DAN+ AP F+ + Y + E
Sbjct: 193 LVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP GT V+ ++A+D+D GIN +I Y S+ + ++ + +F+IN TG I N LD
Sbjct: 253 NAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKS----KFIINSNTGEIKVNGELD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A D LS V + ++DVNDN P + EDA + T +
Sbjct: 309 YEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVI 368
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 ALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESVSVYELVVTAR 427
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 428 DGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENA 487
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPR-KKYELVIR-AASPPLWND 777
+V YS ++ S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 488 LVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSN 547
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 548 VTLQVFVLDENDNAPAL 564
Score = 57.2 bits (132), Expect = 8e-07
Identities = 67/281 (23%), Positives = 123/281 (43%), Gaps = 18/281 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
+I E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 33 SIPEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDR 91
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V + ++DIND+PP F +I E+ +
Sbjct: 92 EELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRF 151
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKY 763
A D D G NA + Y + + + F L+ + ++ ELV LD E ++
Sbjct: 152 PLEGASDLDIGANAQLRYRL---NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHR 208
Query: 764 ELVIR--AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG-RVPAYD 820
LVI P L V++ I V D NDNAP D I + P G ++ A D
Sbjct: 209 LLVIATDGGKPELTGTVQLLINVLDANDNAPEF-DKSIYNVRLLENAPSGTLVIKLNASD 267
Query: 821 AD--VTDKLQY---RILSGNNANLILLNETTGSMTLSPQLN 856
AD + ++ Y ++ + + ++N TG + ++ +L+
Sbjct: 268 ADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELD 308
>AF152307-1|AAD43701.1| 949|Homo sapiens protocadherin alpha 11
protein.
Length = 949
Score = 228 bits (558), Expect = 2e-58
Identities = 179/618 (28%), Positives = 291/618 (47%), Gaps = 36/618 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR ++V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGQSA--ECSIHLEVIVDRPLQVFHVNVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P FS + + + E S + A+DAD+ N+ + Y + + FS+DS +
Sbjct: 131 PVFSLREQKLLIAE--SKQSDSRFPLEGASDADIEENALLTYRL---SKNEYFSLDSPTN 185
Query: 208 D-----VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
+SL+ K+LD E+ L++ A DGG P + T +LL+ + DVNDN P F S
Sbjct: 186 GKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKS 245
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
++ S+ EN ++++ A D DEGVN E+TY++ G T+D +G V
Sbjct: 246 EYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR--HLFTLDQNNGEVRV 303
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
+G LD E Y++ V ATD G PP + T + + ED
Sbjct: 304 NGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQ 363
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRY 437
P T + ++ +D D+ ++ ++T T F + S +N L+ + LD + Y
Sbjct: 364 PSTVIALISV--SDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRENVWAY 420
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D
Sbjct: 421 ELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD 480
Query: 496 SDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
+D NA ++YSL + + A++ + ++ ++G + + LD E + V+AR
Sbjct: 481 ADAQENALVSYSLVERRLGDRALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSAR 537
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATD 607
D GVP LS +++ V+D NDN P + Q +A + LV G V++V A D
Sbjct: 538 DAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVD 597
Query: 608 ADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
AD G N + YEL P F + +G I T +ALD H L + D G P
Sbjct: 598 ADSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPA 657
Query: 667 QSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 658 LTATATVLVSLVESGQAP 675
Score = 211 bits (516), Expect = 2e-53
Identities = 174/609 (28%), Positives = 271/609 (44%), Gaps = 45/609 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF +++ + + E S + A+D DI +NA + Y +
Sbjct: 118 HVNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+L+ + + R+ +L+ + SLDREK +L+ ATD P
Sbjct: 178 FSLDSPTNG----------KQIKRL-----SLILKKSLDREKTPELNLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + V ++D NDN P+F + Y VS+ E+ + ++ K+ ATD D G N +
Sbjct: 221 -ELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAA--KETLVLKLNATDRDEGVNGEV 277
Query: 188 RYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y++ I N + F++D +G+V + TLDYE+ + Y++ ++A D G+P + + +
Sbjct: 278 TYSLMSIKPNGRHLFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWV 337
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D NDN+P + V E+ I + D D GVN ++T ++T
Sbjct: 338 EILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHV---PF 394
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
L T V S LDRE Y+L+VTA DGG P ATA
Sbjct: 395 KLVSTFKNYYSLVLDSA-LDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPA 453
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR- 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 454 FAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAES 513
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF-------EN 471
G + QPLD ++ VSA D+G S +Q+ + D N+ AP
Sbjct: 514 GKVYALQPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAG 573
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
V G V V A D+D G NA ++Y L + F + TG
Sbjct: 574 GAVNKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIP-----FRVGLYTG 628
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 629 EISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRTLAGAASP 688
Query: 592 EDALVGTSV 600
E ALV +V
Sbjct: 689 EAALVDVNV 697
Score = 210 bits (513), Expect = 5e-53
Identities = 159/546 (29%), Positives = 244/546 (44%), Gaps = 27/546 (4%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ A DAD NA LTY ++ +Y +
Sbjct: 121 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYF-S 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D P + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDND 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F +Y+V L E+ T V+ L ATD DE + + Y + GR T G
Sbjct: 240 PEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNG 299
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ V LD+++ + Y + V ATD G + V + I D N+ +P + V
Sbjct: 300 EVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVR 359
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
EDA T + ++S +D D G+N Q+T SL+ + + V+ + ++ + L
Sbjct: 360 EDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYY-------SLVLDSAL 412
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
DRE + Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 413 DRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCH 472
Query: 600 VSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATHDL 655
+ V A DAD N + Y L + DR S+V + SG + + LD E +
Sbjct: 473 IFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQF 532
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGE 708
+ A D G PP SS V + + + D ND+ P + + + G + +
Sbjct: 533 QVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAK 592
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYELVI 767
+RA D D G NA + Y ++ + + R G E+ T LD +SPR + +++
Sbjct: 593 VRAVDADSGYNAWLSYELQPA--AGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLV 650
Query: 768 RAASPP 773
+ P
Sbjct: 651 KDHGEP 656
Score = 177 bits (431), Expect = 5e-43
Identities = 127/415 (30%), Positives = 206/415 (49%), Gaps = 17/415 (4%)
Query: 390 ATDAD-EDNRL-HYEITGGNTRGRFSITS--QNGRGLITVAQPLDFKQERRYVLTVSATD 445
A+DAD E+N L Y ++ S T+ Q R + + + LD ++ L ++ATD
Sbjct: 157 ASDADIEENALLTYRLSKNEYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATD 216
Query: 446 SGGRSDTAMVQ--INITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T V+ + + D N+ P F+ + Y S+ E+A T VL ++ATD D G+N +
Sbjct: 217 GGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGE 276
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
+TYSL S N H F ++ G + N LD E Y + V A D G P ++
Sbjct: 277 VTYSLMSIKPN---GRH--LFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAG 331
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
V + ++D NDN P + + EDA T ++ + +D D G+NG++ L P
Sbjct: 332 HCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPH 391
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
+ ++ + ALDRE+V ++L A DGG+P +T V +++ D+ND+
Sbjct: 392 VPFKLVSTFKNYYSLV-LDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDN 450
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI---KGGDDSNSFSLETR 740
P F T ++ EN+P G I + A D D NA+V YS+ + GD + S +
Sbjct: 451 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVH 510
Query: 741 QGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVRVEILVTDVNDNAPVM 794
S K + +D + E ++++ R A PPL ++V +++ V D NDNAP +
Sbjct: 511 AESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPAL 564
Score = 157 bits (382), Expect = 4e-37
Identities = 133/447 (29%), Positives = 202/447 (45%), Gaps = 20/447 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + + D N+ PVF + E + + A+D+D+ NA +TY LS N
Sbjct: 119 VNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSK---N 175
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
E + + ++ K LDRE L +TA DGG P L+ T + + V+DV
Sbjct: 176 EYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDV 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL-DPKDREEGSFVID 633
NDN+P F + Y ++ME+A T V ++ ATD D G+NG + Y L K F +D
Sbjct: 236 NDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLD 295
Query: 634 PASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+G +R N LD E + ++ A D GTPP + V ++I D ND+ P L+
Sbjct: 296 QNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLS 355
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVD 753
+ E++ T I I D D G N V S+ F L + LV
Sbjct: 356 LPVREDAQPSTVIALISVSDRDSGVNGQVTCSL---TPHVPFKL-VSTFKNYYSLVLDSA 411
Query: 754 LDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPV 810
LD E+ YELV+ A SP LW RV + V DVNDNAP + ++ P
Sbjct: 412 LDRENV-WAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 470
Query: 811 GPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPKLA 863
V A DAD + + Y ++ G+ A + + ++ +G + L+ +L
Sbjct: 471 CHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELL 530
Query: 864 TMEVSVTD-GVNEIKAMMQLSVRLITE 889
+VS D GV + + + L V ++ E
Sbjct: 531 QFQVSARDAGVPPLSSNVTLQVFVLDE 557
Score = 103 bits (248), Expect = 7e-21
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 26/328 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVSEEAKHGTFVGRIA---QDLGLELA---ELVQRLFRVASKTHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V + V D+NDN PVF + I E
Sbjct: 88 SRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDINDNPPVFSLREQKLLIAESKQ 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG------VIRTNKALDRES 649
+ GA+DAD+ N + Y L + E + P +G + K+LDRE
Sbjct: 148 SDSRFPLEGASDADIEENALLTYRL---SKNEYFSLDSPTNGKQIKRLSLILKKSLDREK 204
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
+L A DGG P + TV + +++ D+ND+ P F+ + EN+ T + ++
Sbjct: 205 TPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKL 264
Query: 710 RAHDPDEGPNAVVHYSIKG--GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI 767
A D DEG N V YS+ + + F+L+ G E+ LDYE K Y++ +
Sbjct: 265 NATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNG----EVRVNGTLDYEE-NKFYKIEV 319
Query: 768 RA---ASPPLWNDVRVEILVTDVNDNAP 792
+A +PP+ V + + D NDN+P
Sbjct: 320 QATDKGTPPMAGHCTVWVEILDTNDNSP 347
>AF152304-1|AAD43698.1| 1007|Homo sapiens protocadherin alpha C2
protein.
Length = 1007
Score = 228 bits (558), Expect = 2e-58
Identities = 173/584 (29%), Positives = 266/584 (45%), Gaps = 56/584 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ +LD ND+SP F Y+ V E + G A D D+G N+ Y
Sbjct: 135 EVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTY--------E 186
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
L+P + V L+ R LDRE+ A + +++ A D P
Sbjct: 187 LSPSEHFELDLKPLQENSKVLE-------LVLRKGLDREQAALHHLVLTAVDGGIPAR-- 237
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S TA I V ++D NDN P F + TY V + ED ++ K+ A+D D G+N +RY
Sbjct: 238 -SGTAQISVRVLDTNDNSPAFDQSTYRVQLRED--SPPGTLVVKLNASDPDEGSNGELRY 294
Query: 190 AIIGGNTQMQ---FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
++ + + FSID+ +G+V ++ LDYE+ SY++ ++A D G + ++L++
Sbjct: 295 SLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVD 354
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
I DVNDNAP + V EN + + D D G N +++ +
Sbjct: 355 IVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGL-------EAT 407
Query: 307 LPITID--PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
LP ++ S + SG LDRE A Y + VTATDGG P ++ T
Sbjct: 408 LPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPP 467
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADEDNR-------LHYEITGGNTRGRFSITSQ 417
F+ Y + + E+ PG + T+ ATD DE L EI G SI S
Sbjct: 468 SFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSA 527
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAP 473
+G + D+++ R + +TV A D G S T + + D N++AP ++ +
Sbjct: 528 SGS--LYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTST 585
Query: 474 YTASVFE----DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++ FE AP G V V A DSD G NA + Y L+ + F +
Sbjct: 586 NSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDL-------FKVELH 638
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I T + + E+ S + LTV RD G PSLS + + ++VVD
Sbjct: 639 TGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVD 682
Score = 228 bits (557), Expect = 3e-58
Identities = 177/603 (29%), Positives = 275/603 (45%), Gaps = 27/603 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D SGAL +DRE + + ++ + + + V I+D NDN P+F
Sbjct: 92 LDLTSGALFVNERIDREALCEQRP--RCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG---- 207
Y + V E SV A D DVGANS Y + + + + L
Sbjct: 150 RPNYQLQVSE--SVAPGARFHIESAQDPDVGANSVQTYEL-SPSEHFELDLKPLQENSKV 206
Query: 208 -DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD EQ + LV+ A DGG P+RS T Q+ + + D NDN+P F S ++ +
Sbjct: 207 LELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQL 266
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI-TIDPRSGWVYTSGQLD 325
E+ P G +V++ A D DEG N EL Y+++ YT + + + +ID +G V G LD
Sbjct: 267 REDSPPGTLVVKLNASDPDEGSNGELRYSLS--SYTSDRERQLFSIDASTGEVRVIGGLD 324
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E + YQ+ V ATD G P + + + E+ P T V
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIV 384
Query: 386 VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATD 445
L+ D D + G F + + V+ PLD ++ Y +TV+ATD
Sbjct: 385 AVLSVNDQDSGPNRKVSL-GLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATD 443
Query: 446 SGGRSDTAM--VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T++ +++ I+D N+ P F Y+ + E+ G + V ATD D NA+
Sbjct: 444 GGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAE 503
Query: 504 ITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
+TYS L EI V + IN +G++ D E + +TV A+D G P LS
Sbjct: 504 VTYSLLEREIQGLPVTSY---VSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLS 560
Query: 563 DTTDVEISVVDVNDNEPVFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLNGRI 616
T + VVD+ND+ P T + + A G V++V A D+D G N +
Sbjct: 561 STVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWL 620
Query: 617 HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIK 676
Y L + + F ++ +G IRT + + ES +T +L V D G P S++V + +
Sbjct: 621 FYHL-AQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVA 679
Query: 677 IED 679
+ D
Sbjct: 680 VVD 682
Score = 183 bits (446), Expect = 7e-45
Identities = 166/604 (27%), Positives = 279/604 (46%), Gaps = 37/604 (6%)
Query: 309 ITIDPRSGWVYTSGQLDRET--QAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+ +D SG ++ + ++DRE + + + L++ P + +A
Sbjct: 90 LELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFP 149
Query: 367 MPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGG-NTRGRFSITSQNGRGL- 422
P Y+++++E PG +A D D N + YE++ + +N + L
Sbjct: 150 RPN-YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLE 208
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +Q + L ++A D G RS TA + + + D N+ +P F+ + Y + E
Sbjct: 209 LVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLRE 268
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
D+P GT V+ ++A+D D G N ++ YSLSS S+ Q F I+ TG + LD
Sbjct: 269 DSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDR----ERQLFSIDASTGEVRVIGGLD 324
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALVGTS 599
E S Y + V A D G ++ V + +VDVNDN P V LY+ + E+A T
Sbjct: 325 YEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSP-VPENATPNTI 383
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
V+ + D D G N ++ L+ + + + V+ + LDRE VA +++ A
Sbjct: 384 VAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVV--SGPLDRERVAVYNITVTA 441
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG P +S + ++I DIND+PP F D + YI EN+ G + ++A DPDE N
Sbjct: 442 TDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKEN 501
Query: 720 AVVHYS-----IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR--AASP 772
A V YS I+G ++ S+ + GS L + DYE R+ + V SP
Sbjct: 502 AEVTYSLLEREIQGLPVTSYVSINSASGS----LYAVNSFDYEKFREFFVTVEAQDKGSP 557
Query: 773 PLWNDVRVEILVTDVNDNA-----PVMKDFQIIFNNYKDCFPVGPF-GRVPAYDADVTDK 826
PL + V + V D+ND+A P + F P G +V A D+D
Sbjct: 558 PLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQN 617
Query: 827 --LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLS 883
L Y + ++ +L + TG + + ++ + V V D G + A + ++
Sbjct: 618 AWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAIT 677
Query: 884 VRLI 887
V ++
Sbjct: 678 VAVV 681
>AC005609-9|AAC34321.1| 816|Homo sapiens KIAA0345-like 9 protein.
Length = 816
Score = 228 bits (558), Expect = 2e-58
Identities = 171/617 (27%), Positives = 283/617 (45%), Gaps = 33/617 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ R + + + DR + V + D NDN
Sbjct: 72 DLLEVNLQNGILFVNSRIDREELCRRRA--ECSIHLEVIVDRPLQVFHVEVAVKDINDNP 129
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P+FS + + + E + D+ + A+D D+GAN+ +RY + N F +D +
Sbjct: 130 PRFSRQEQRLFILES-RMPDSRFPLE-GASDLDIGANAQLRYRL---NPNEYFDLDVKTN 184
Query: 208 D-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
+ + L K+LD E+ + +RL++ A DGG P + T QLLIN+ D NDNAP F S
Sbjct: 185 EEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKS 244
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
++ + EN P G ++++ A DADEG+N E+ Y ++ +V I+ +G +
Sbjct: 245 IYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNL-VLDDVKSKFIINSNTGEIKV 303
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
+G+LD E Y++ + A D P S + + ED P
Sbjct: 304 NGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAP 363
Query: 381 PGTPVVTLTATDADEDNRLHYEITGG---NTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T + ++ +D D+ + ++T + + T +N L+ + LD + Y
Sbjct: 364 LSTVIALISV--SDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESVSVY 420
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D
Sbjct: 421 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARD 480
Query: 496 SDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
+D NA ++YSL E ++ ++G + + LD E + V+ARD
Sbjct: 481 ADAQENALVSYSLVERRVGERPL--SSYVSVHAESGKVYALQPLDHEEVELLQFQVSARD 538
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDA 608
GVP L +++ V+D NDN P T + + + G V++V A D
Sbjct: 539 AGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDP 598
Query: 609 DVGLNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
D G N + YEL P F + +G I T ++LD H L + D G PP
Sbjct: 599 DSGYNAWLSYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPL 658
Query: 668 SSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 659 TATATVLVSLVESGQAP 675
Score = 214 bits (523), Expect = 3e-54
Identities = 165/553 (29%), Positives = 249/553 (45%), Gaps = 37/553 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN PRF + + E+ A D D G NA+L Y + +Y
Sbjct: 120 VAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEY--- 176
Query: 305 VDLPI-TIDPRSGWV--YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
DL + T + + ++ LDRE +++LLV ATDGG P + T
Sbjct: 177 FDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDAND 236
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSITS 416
F Y V L E+ P GT V+ L A+DADE + + Y + + + +F I S
Sbjct: 237 NAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINS 296
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPY 474
G I V LD++ Y + + A D S V + + D N+ P
Sbjct: 297 NTGE--IKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTL 354
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
V EDAP+ T + ++S +D D G N Q+T SL + + V+ + ++
Sbjct: 355 FLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLV 407
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 408 LDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENN 467
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESV 650
G + V A DAD N + Y L + +R S+V + SG + + LD E V
Sbjct: 468 PPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEV 527
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIG 703
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 528 ELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAG 587
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKK 762
+ ++RA DPD G NA + Y ++ S + R G E+ T LD E+PR +
Sbjct: 588 HVVAKVRAVDPDSGYNAWLSYELQPA--PGSARIPFRVGLYTGEISTTRSLDETEAPRHR 645
Query: 763 YELVIR-AASPPL 774
++++ PPL
Sbjct: 646 LLVLVKDHGEPPL 658
Score = 200 bits (489), Expect = 4e-50
Identities = 163/584 (27%), Positives = 258/584 (44%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ P F Q+ + E + A+D DIG NA++ Y
Sbjct: 117 HVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRY------- 169
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
LNP + + L+ R SLDRE+ + +LV ATD P
Sbjct: 170 -RLNPNEYFDLDVKTNEEETNFLE-------LVLRKSLDREETQEHRLLVIATDGGKP-- 219
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + +N++D NDN P+F + Y V + E + ++ K+ A+DAD G N I
Sbjct: 220 -ELTGTVQLLINVLDANDNAPEFDKSIYNVRLLE--NAPSGTLVIKLNASDADEGINKEI 276
Query: 188 RY---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y ++ + + +F I+S +G++ + LDYE SY + I A D + S +++
Sbjct: 277 VYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVV 336
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDN P + V E+ P+ I + D D G N ++T ++ +
Sbjct: 337 VKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP-----H 391
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNG 419
F QY V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHA 511
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 512 ESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGG 571
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ V G V V A D D G NA ++Y L + + F +
Sbjct: 572 TGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARI-----PFRVGLY 626
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G P L+ T V +S+V+
Sbjct: 627 TGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLVE 670
Score = 192 bits (469), Expect = 1e-47
Identities = 119/377 (31%), Positives = 196/377 (51%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQ--INITDANNYAPVFENAPYTASVFE 480
+ + + LD ++ + + L V ATD G T VQ IN+ DAN+ AP F+ + Y + E
Sbjct: 193 LVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP GT V+ ++A+D+D GIN +I Y S+ + ++ + +F+IN TG I N LD
Sbjct: 253 NAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKS----KFIINSNTGEIKVNGELD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A D LS V + ++DVNDN P + EDA + T +
Sbjct: 309 YEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVI 368
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 ALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESVSVYELVVTAR 427
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 428 DGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENA 487
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPR-KKYELVIR-AASPPLWND 777
+V YS ++ S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 488 LVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSN 547
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 548 VTLQVFVLDENDNAPAL 564
Score = 57.2 bits (132), Expect = 8e-07
Identities = 67/281 (23%), Positives = 123/281 (43%), Gaps = 18/281 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
+I E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 33 SIPEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDR 91
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V + ++DIND+PP F +I E+ +
Sbjct: 92 EELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRF 151
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKY 763
A D D G NA + Y + + + F L+ + ++ ELV LD E ++
Sbjct: 152 PLEGASDLDIGANAQLRYRL---NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHR 208
Query: 764 ELVIR--AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG-RVPAYD 820
LVI P L V++ I V D NDNAP D I + P G ++ A D
Sbjct: 209 LLVIATDGGKPELTGTVQLLINVLDANDNAPEF-DKSIYNVRLLENAPSGTLVIKLNASD 267
Query: 821 AD--VTDKLQY---RILSGNNANLILLNETTGSMTLSPQLN 856
AD + ++ Y ++ + + ++N TG + ++ +L+
Sbjct: 268 ADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELD 308
>AC005609-3|AAC34316.1| 810|Homo sapiens KIAA0345-like 3 protein.
Length = 810
Score = 228 bits (558), Expect = 2e-58
Identities = 179/618 (28%), Positives = 291/618 (47%), Gaps = 36/618 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR ++V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGQSA--ECSIHLEVIVDRPLQVFHVNVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P FS + + + E S + A+DAD+ N+ + Y + + FS+DS +
Sbjct: 131 PVFSLREQKLLIAE--SKQSDSRFPLEGASDADIEENALLTYRL---SKNEYFSLDSPTN 185
Query: 208 D-----VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
+SL+ K+LD E+ L++ A DGG P + T +LL+ + DVNDN P F S
Sbjct: 186 GKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKS 245
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
++ S+ EN ++++ A D DEGVN E+TY++ G T+D +G V
Sbjct: 246 EYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR--HLFTLDQNNGEVRV 303
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
+G LD E Y++ V ATD G PP + T + + ED
Sbjct: 304 NGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQ 363
Query: 381 PGTPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRY 437
P T + ++ +D D+ ++ ++T T F + S +N L+ + LD + Y
Sbjct: 364 PSTVIALISV--SDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLV-LDSALDRENVWAY 420
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D
Sbjct: 421 ELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARD 480
Query: 496 SDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTAR 554
+D NA ++YSL + + A++ + ++ ++G + + LD E + V+AR
Sbjct: 481 ADAQENALVSYSLVERRLGDRALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSAR 537
Query: 555 DGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATD 607
D GVP LS +++ V+D NDN P + Q +A + LV G V++V A D
Sbjct: 538 DAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVD 597
Query: 608 ADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
AD G N + YEL P F + +G I T +ALD H L + D G P
Sbjct: 598 ADSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPA 657
Query: 667 QSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 658 LTATATVLVSLVESGQAP 675
Score = 211 bits (516), Expect = 2e-53
Identities = 174/609 (28%), Positives = 271/609 (44%), Gaps = 45/609 (7%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF +++ + + E S + A+D DI +NA + Y +
Sbjct: 118 HVNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEY 177
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+L+ + + R+ +L+ + SLDREK +L+ ATD P
Sbjct: 178 FSLDSPTNG----------KQIKRL-----SLILKKSLDREKTPELNLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + V ++D NDN P+F + Y VS+ E+ + ++ K+ ATD D G N +
Sbjct: 221 -ELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAA--KETLVLKLNATDRDEGVNGEV 277
Query: 188 RYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y++ I N + F++D +G+V + TLDYE+ + Y++ ++A D G+P + + +
Sbjct: 278 TYSLMSIKPNGRHLFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWV 337
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
I D NDN+P + V E+ I + D D GVN ++T ++T
Sbjct: 338 EILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHV---PF 394
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
L T V S LDRE Y+L+VTA DGG P ATA
Sbjct: 395 KLVSTFKNYYSLVLDSA-LDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPA 453
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNGR- 420
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 454 FAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAES 513
Query: 421 GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF-------EN 471
G + QPLD ++ VSA D+G S +Q+ + D N+ AP
Sbjct: 514 GKVYALQPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAG 573
Query: 472 APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
V G V V A D+D G NA ++Y L + F + TG
Sbjct: 574 GAVNKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIP-----FRVGLYTG 628
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
I+T + LD + L V +D G P+L+ T V +S+V+ + L A
Sbjct: 629 EISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRTLAGAASP 688
Query: 592 EDALVGTSV 600
E ALV +V
Sbjct: 689 EAALVDVNV 697
Score = 210 bits (513), Expect = 5e-53
Identities = 159/546 (29%), Positives = 244/546 (44%), Gaps = 27/546 (4%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ A DAD NA LTY ++ +Y +
Sbjct: 121 VEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYF-S 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D P + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDND 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F +Y+V L E+ T V+ L ATD DE + + Y + GR T G
Sbjct: 240 PEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNG 299
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ V LD+++ + Y + V ATD G + V + I D N+ +P + V
Sbjct: 300 EVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVR 359
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
EDA T + ++S +D D G+N Q+T SL+ + + V+ + ++ + L
Sbjct: 360 EDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYY-------SLVLDSAL 412
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
DRE + Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+ G
Sbjct: 413 DRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCH 472
Query: 600 VSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVATHDL 655
+ V A DAD N + Y L + DR S+V + SG + + LD E +
Sbjct: 473 IFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQF 532
Query: 656 KAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTTIGE 708
+ A D G PP SS V + + + D ND+ P + + + G + +
Sbjct: 533 QVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAK 592
Query: 709 IRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYELVI 767
+RA D D G NA + Y ++ + + R G E+ T LD +SPR + +++
Sbjct: 593 VRAVDADSGYNAWLSYELQPA--AGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLV 650
Query: 768 RAASPP 773
+ P
Sbjct: 651 KDHGEP 656
Score = 177 bits (431), Expect = 5e-43
Identities = 127/415 (30%), Positives = 206/415 (49%), Gaps = 17/415 (4%)
Query: 390 ATDAD-EDNRL-HYEITGGNTRGRFSITS--QNGRGLITVAQPLDFKQERRYVLTVSATD 445
A+DAD E+N L Y ++ S T+ Q R + + + LD ++ L ++ATD
Sbjct: 157 ASDADIEENALLTYRLSKNEYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATD 216
Query: 446 SGGRSDTAMVQ--INITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQ 503
G T V+ + + D N+ P F+ + Y S+ E+A T VL ++ATD D G+N +
Sbjct: 217 GGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGE 276
Query: 504 ITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSD 563
+TYSL S N H F ++ G + N LD E Y + V A D G P ++
Sbjct: 277 VTYSLMSIKPN---GRH--LFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAG 331
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK 623
V + ++D NDN P + + EDA T ++ + +D D G+NG++ L P
Sbjct: 332 HCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPH 391
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDS 683
+ ++ + ALDRE+V ++L A DGG+P +T V +++ D+ND+
Sbjct: 392 VPFKLVSTFKNYYSLV-LDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDN 450
Query: 684 PPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSI---KGGDDSNSFSLETR 740
P F T ++ EN+P G I + A D D NA+V YS+ + GD + S +
Sbjct: 451 APAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVH 510
Query: 741 QGSDKAELVTMVDLDYESPRKKYELVIRAAS-PPLWNDVRVEILVTDVNDNAPVM 794
S K + +D + E ++++ R A PPL ++V +++ V D NDNAP +
Sbjct: 511 AESGKVYALQPLDHE-ELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPAL 564
Score = 157 bits (382), Expect = 4e-37
Identities = 133/447 (29%), Positives = 202/447 (45%), Gaps = 20/447 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V + + D N+ PVF + E + + A+D+D+ NA +TY LS N
Sbjct: 119 VNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSK---N 175
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
E + + ++ K LDRE L +TA DGG P L+ T + + V+DV
Sbjct: 176 EYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDV 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL-DPKDREEGSFVID 633
NDN+P F + Y ++ME+A T V ++ ATD D G+NG + Y L K F +D
Sbjct: 236 NDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLD 295
Query: 634 PASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+G +R N LD E + ++ A D GTPP + V ++I D ND+ P L+
Sbjct: 296 QNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLS 355
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVD 753
+ E++ T I I D D G N V S+ F L + LV
Sbjct: 356 LPVREDAQPSTVIALISVSDRDSGVNGQVTCSL---TPHVPFKL-VSTFKNYYSLVLDSA 411
Query: 754 LDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPV 810
LD E+ YELV+ A SP LW RV + V DVNDNAP + ++ P
Sbjct: 412 LDRENV-WAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPG 470
Query: 811 GPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVPKLA 863
V A DAD + + Y ++ G+ A + + ++ +G + L+ +L
Sbjct: 471 CHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELL 530
Query: 864 TMEVSVTD-GVNEIKAMMQLSVRLITE 889
+VS D GV + + + L V ++ E
Sbjct: 531 QFQVSARDAGVPPLSSNVTLQVFVLDE 557
Score = 103 bits (248), Expect = 7e-21
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 26/328 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVSEEAKHGTFVGRIA---QDLGLELA---ELVQRLFRVASKTHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V + V D+NDN PVF + I E
Sbjct: 88 SRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDINDNPPVFSLREQKLLIAESKQ 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG------VIRTNKALDRES 649
+ GA+DAD+ N + Y L + E + P +G + K+LDRE
Sbjct: 148 SDSRFPLEGASDADIEENALLTYRL---SKNEYFSLDSPTNGKQIKRLSLILKKSLDREK 204
Query: 650 VATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEI 709
+L A DGG P + TV + +++ D+ND+ P F+ + EN+ T + ++
Sbjct: 205 TPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKL 264
Query: 710 RAHDPDEGPNAVVHYSIKG--GDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVI 767
A D DEG N V YS+ + + F+L+ G E+ LDYE K Y++ +
Sbjct: 265 NATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNG----EVRVNGTLDYEE-NKFYKIEV 319
Query: 768 RA---ASPPLWNDVRVEILVTDVNDNAP 792
+A +PP+ V + + D NDN+P
Sbjct: 320 QATDKGTPPMAGHCTVWVEILDTNDNSP 347
>AB011160-1|BAA25514.2| 938|Homo sapiens KIAA0588 protein protein.
Length = 938
Score = 228 bits (558), Expect = 2e-58
Identities = 186/607 (30%), Positives = 277/607 (45%), Gaps = 30/607 (4%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + + + D++ + V + D NDN P
Sbjct: 80 LFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDIL-MEDKVKIYG-VEVEVRDINDNAP 137
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSID----- 203
F E + + E+ + + A D D+G NS Y + NT +
Sbjct: 138 YFRESELEIKISENAATEMRFPLPH--AWDPDIGKNSLQSYEL-SPNTHFSLIVQNGADG 194
Query: 204 SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
S ++ L + LD E+ ++ LV+ A DGG P R+ T ++ + + D NDNAP F ++
Sbjct: 195 SKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYR 254
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
SV EN+ +G ++ V A D DEGVNAE+ Y+ D +D SG + T G+
Sbjct: 255 ASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVD--DKAAQVFKLDCNSGTISTIGE 312
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E YQ+ V A D SA A + + E+ P GT
Sbjct: 313 LDHEESGFYQMEVQAMDNAG--YSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGT 370
Query: 384 PVVTLTATDAD-EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
+ L D D E+N GN + + N L+T LD +Q Y +TV+
Sbjct: 371 LIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDI-VLDREQVPSYNITVT 429
Query: 443 ATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S + +N+ D N+ PVF A Y+A + E+ P G +++ V+A D D
Sbjct: 430 ATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEE 489
Query: 501 NAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
NAQITYSL+ A IN TG + D E + V ARD G P
Sbjct: 490 NAQITYSLAENTIQGASL--SSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPP 547
Query: 561 LSDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLN 613
LS + + V+D NDN P + L T A G V++V A D D G N
Sbjct: 548 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 607
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSSTVI 672
+ Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+TV
Sbjct: 608 AWLSYRL-LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSATVT 665
Query: 673 VHIKIED 679
+ + + D
Sbjct: 666 LTVAVAD 672
Score = 188 bits (459), Expect = 2e-46
Identities = 169/585 (28%), Positives = 261/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND++P F + E + E A++ A D DIGKN+ Y + T +
Sbjct: 126 EVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFS 185
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L ++ DG + L+ + +LDRE+ A + +++ A+D PV
Sbjct: 186 LIVQNGA----------------DGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVR- 228
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
+ TA I V ++D NDN P F++ Y SV E++++ ++ + ATD D G N+ +R
Sbjct: 229 --TGTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLV--VNATDPDEGVNAEVR 284
Query: 189 YAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ + F +D SG +S + LD+E+ Y++ ++A D + S ++LI
Sbjct: 285 YSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMD--NAGYSARAKVLIT 342
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDNAP + SV EN P G I + D D N ++ + GN
Sbjct: 343 VLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDSEENGQVICFI-----QGN-- 395
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ G Y T LDRE Y + VTATD G PP S
Sbjct: 396 LPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNP 455
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G +V++TA D D E+ ++ Y + +G S S N
Sbjct: 456 PVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINS 515
Query: 420 -RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAP--VFENAPY 474
G++ D++Q R + V A D+G S + + + D N+ AP ++ P
Sbjct: 516 DTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPT 575
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 576 DGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK-------ASEPGLFSVGLH 628
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 629 TGEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 672
Score = 186 bits (454), Expect = 8e-46
Identities = 166/601 (27%), Positives = 279/601 (46%), Gaps = 42/601 (6%)
Query: 311 IDPRSGWVYTSGQLDRETQAKYQLLVTAT-DGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE + D + F
Sbjct: 83 LNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRES 142
Query: 370 QYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRG-----L 422
+ E++++E+ A D D +++ YE++ NT FS+ QNG
Sbjct: 143 ELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSP-NTH--FSLIVQNGADGSKYPE 199
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +++ + L ++A+D G R+ TA +++ + DAN+ AP F Y ASV E
Sbjct: 200 LVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPE 259
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ +GT +LVV+ATD D G+NA++ YS + ++A Q F ++ +G I+T LD
Sbjct: 260 NLALGTQLLVVNATDPDEGVNAEVRYSFRY-VDDKAA----QVFKLDCNSGTISTIGELD 314
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A D S V I+V+DVNDN P +++ E++ GT +
Sbjct: 315 HEESGFYQMEVQAMDNA--GYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLI 372
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ + D D NG++ + + F ++ + G + T+ LDRE V ++++
Sbjct: 373 ALLNVNDQDSEENGQVICFI----QGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITV 428
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP S+ + + + D ND+PPVF + YI EN+P G ++ + AHDPD
Sbjct: 429 TATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCE 488
Query: 718 PNAVVHYSI-KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPPL 774
NA + YS+ + S S SD L + DYE R + +++ R PPL
Sbjct: 489 ENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPL 548
Query: 775 WNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------DADVT 824
++V + + V D NDNAP + + + + + P P Y D+
Sbjct: 549 SSNVSLSLFVLDQNDNAPEIL-YPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 607
Query: 825 DKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLS 883
L YR+L + L + TG + + L ++ V+V D G + A + L+
Sbjct: 608 AWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLT 667
Query: 884 V 884
V
Sbjct: 668 V 668
Score = 168 bits (409), Expect = 2e-40
Identities = 139/472 (29%), Positives = 211/472 (44%), Gaps = 42/472 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD ND++P F +Y ASV E + GT +L + ATD D G NAEV Y+ V
Sbjct: 235 RVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYV---- 290
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+D VF++D SG + T LD E+ Y + V+A D A
Sbjct: 291 ---DDKAA----------QVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAG----- 332
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S+ A + + ++D NDN P+ + SV E + +IA + D D N +
Sbjct: 333 YSARAKVLITVLDVNDNAPEVVLTSLASSVPE--NSPRGTLIALLNVNDQDSEENGQV-I 389
Query: 190 AIIGGNTQMQFSIDSLSGD-VSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I GN + F ++ G+ SLV LD EQV SY + + A D G+P S T + +N
Sbjct: 390 CFIQGN--LPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLN 447
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ D NDN P F + + + EN P G S+V V A+D D NA++TY++ + G ++
Sbjct: 448 VADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASL 507
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E Q+ V A D G PP S+ +
Sbjct: 508 SSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPE 567
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G VELA PG V + A D D L Y + + G FS+
Sbjct: 568 ILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGL 627
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A++ V
Sbjct: 628 HTGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQV 677
Score = 124 bits (300), Expect = 3e-27
Identities = 90/280 (32%), Positives = 136/280 (48%), Gaps = 16/280 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETM-SGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
Q F +NP++G++ T +DRE + G + D + VE+ V D+NDN P
Sbjct: 79 QLFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPY 138
Query: 581 FKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--- 637
F++ I E+A A D D+G N YEL P + V + A G
Sbjct: 139 FRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSP-NTHFSLIVQNGADGSKY 197
Query: 638 -VIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYI 696
+ +ALDRE A H L A DGG P ++ T + + + D ND+ P F +
Sbjct: 198 PELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASV 257
Query: 697 SENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDL 754
EN +GT + + A DPDEG NA V YS + DD + F L+ G+ + T+ +L
Sbjct: 258 PENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGT----ISTIGEL 313
Query: 755 DYESPRKKYELVIRAASPPLWNDVRVEILVT--DVNDNAP 792
D+E Y++ ++A ++ R ++L+T DVNDNAP
Sbjct: 314 DHEE-SGFYQMEVQAMDNAGYS-ARAKVLITVLDVNDNAP 351
Score = 84.2 bits (199), Expect = 6e-15
Identities = 62/247 (25%), Positives = 104/247 (42%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H +NV D ND+ PVF Y A + E G +++++ A D D +NA++ Y++
Sbjct: 443 HISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSL---AE 499
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+T+ + I+ +G L +S D E+ V V A D P
Sbjct: 500 NTIQ-----------GASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHP-- 546
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDI-----SVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN P+ + S ++ K+ A D D G
Sbjct: 547 -PLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG 605
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ + FS+ +G+V + L LV+ QD G P S T
Sbjct: 606 QNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT 665
Query: 243 LLINIRD 249
L + + D
Sbjct: 666 LTVAVAD 672
Score = 72.5 bits (170), Expect = 2e-11
Identities = 62/203 (30%), Positives = 95/203 (46%), Gaps = 16/203 (7%)
Query: 601 SQVGATDADVGLNGRIHYE----LDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
S+VG D+GL R E + P+ R + F ++P SG + T +DRE + +K
Sbjct: 49 SRVGDISRDLGLEPRELAERGVRIIPRGRTQ-LFALNPRSGSLVTAGRIDREELCMGAIK 107
Query: 657 A-VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
+ +D + V +++ DIND+ P F L ISEN+ A DPD
Sbjct: 108 CQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPD 167
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKYELVIRAA-- 770
G N++ Y + + FSL + G+D + ELV LD E + + LV+ A+
Sbjct: 168 IGKNSLQSYEL---SPNTHFSLIVQNGADGSKYPELVLKRALDREE-KAAHHLVLTASDG 223
Query: 771 -SPPLWNDVRVEILVTDVNDNAP 792
P R+ ++V D NDNAP
Sbjct: 224 GDPVRTGTARIRVMVLDANDNAP 246
>AF152519-1|AAD43779.1| 814|Homo sapiens protocadherin gamma B3
short form protein protein.
Length = 814
Score = 227 bits (556), Expect = 3e-58
Identities = 175/607 (28%), Positives = 287/607 (47%), Gaps = 32/607 (5%)
Query: 90 FRIDGRSGALLTRASLDREKVA-RYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + +G LL +DRE++ + + V + V+++ + + V I D NDN P
Sbjct: 75 FTVSPENGNLLVSDRIDREEICGKKSTCVLEFEM---VAEKPLNFFHVTVLIQDINDNPP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
FS+ + + E +++T A A D DVG NS +Y + ++L G
Sbjct: 132 TFSQNITELEISE-LALT-GATFALESAQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGS 189
Query: 208 ---DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++ L LD E+ + LV+ A DGG PSRS TTQ+ + + D NDN P F +++
Sbjct: 190 RYPELVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRV 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
+V+EN+P G S+++V A D DEG+NAE+ Y + V +D ++G + T G+L
Sbjct: 250 NVAENLPAGSSVLKVMAIDMDEGINAEIIYAFI--NIGKEVRQLFKLDSKTGELTTIGEL 307
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E + Y + V A DGG +A + ED GT
Sbjct: 308 DFEERDSYTIGVEAKDGGH--HTAYCKVQIDISDENDNAPEITLASESQHIQEDAELGTA 365
Query: 385 VVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
V + D D + + ++ GN + ++N L+T LD +Q Y +T++
Sbjct: 366 VALIKTHDLDSGFNGEILCQLK-GNFPFKIVQDTKNTYRLVTDG-ALDREQIPEYNVTIT 423
Query: 443 ATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S + + ++I D N+ PVF A YT V E+ P G ++ V A+D D+G
Sbjct: 424 ATDKGNPPLSSSKTITLHILDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASDPDLGP 483
Query: 501 NAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
N ++Y + +S++ ++ + ++ ++G + + D E + + LT+ ARD G P
Sbjct: 484 NGLVSYYIVASDLEPRELSSY---VSVSARSGVVFAQRAFDHEQLRAFELTLQARDQGSP 540
Query: 560 SLSDTTDVEISVVDVNDNEPVF-------KQQLYTANIMEDALVGTSVSQVGATDADVGL 612
+LS + + V D NDN P+ + + A G V++V A DAD G
Sbjct: 541 TLSANVSLRVLVDDRNDNAPLVLYPALGPEGSALFDMVPRSAEPGYLVTKVVAVDADSGY 600
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI 672
N + Y + + E G F + +G +RT + L A L DGG P S+TV+
Sbjct: 601 NAWLSYHI-VQASEPGLFSLGLRTGEVRTARTLGDREAARQRLLVTVRDGGQQPLSATVM 659
Query: 673 VHIKIED 679
+H+ D
Sbjct: 660 LHLIFAD 666
Score = 208 bits (509), Expect = 2e-52
Identities = 172/585 (29%), Positives = 272/585 (46%), Gaps = 55/585 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D ND+ P F E + E A +G T A D D+G N+ +Y
Sbjct: 118 HVTVLIQDINDNPPTFSQNITELEISELALTGATFALESAQDPDVGVNSLQQY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPV 126
L+P+ +Q +DG R L+ +A LDRE+ + +++ A D P
Sbjct: 171 -YLSPDP-------HFSLIQKE-NLDGSRYPELVLKAPLDREEQPHHHLVLTAVDGGEP- 220
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
S T I V + D NDN P F++ Y V+V E++ + + K+ A D D G N+
Sbjct: 221 --SRSCTTQIRVIVADANDNPPVFTQDMYRVNVAENLPAGSS--VLKVMAIDMDEGINAE 276
Query: 187 IRYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
I YA IG + F +DS +G+++ + LD+E+ SY + + A+DGG + Q
Sbjct: 277 IIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTIGVEAKDGGHHTAYCKVQ-- 334
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
I+I D NDNAP + + + E+ +G ++ ++ +D D G N E+ + GN
Sbjct: 335 IDISDENDNAPEITLASESQHIQEDAELGTAVALIKTHDLDSGFNGEILCQL-----KGN 389
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
I D ++ + + T G LDRE +Y + +TATD G+PP S++ T
Sbjct: 390 FPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITATDKGNPPLSSSKTITLHILDVNDNV 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR--FSITSQNG 419
F Y V +AE+ PPG + + A+D D + + Y I + R S S +
Sbjct: 450 PVFHQASYTVHVAENNPPGASIAHVRASDPDLGPNGLVSYYIVASDLEPRELSSYVSVSA 509
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQIN--ITDANNYAPVF---ENAP 473
R G++ + D +Q R + LT+ A D G + +A V + + D N+ AP+ P
Sbjct: 510 RSGVVFAQRAFDHEQLRAFELTLQARDQGSPTLSANVSLRVLVDDRNDNAPLVLYPALGP 569
Query: 474 YTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++F+ P G V V A D+D G NA ++Y + A F + +
Sbjct: 570 EGSALFDMVPRSAEPGYLVTKVVAVDADSGYNAWLSYHI-------VQASEPGLFSLGLR 622
Query: 530 TGAITTNKLL-DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T + L DRE LL VT RDGG LS T + + D
Sbjct: 623 TGEVRTARTLGDREAARQRLL-VTVRDGGQQPLSATVMLHLIFAD 666
Score = 202 bits (494), Expect = 1e-50
Identities = 150/466 (32%), Positives = 228/466 (48%), Gaps = 26/466 (5%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + PLD +++ + L ++A D G RS T +++ + DAN+ PVF Y +V E
Sbjct: 194 LVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRVNVAE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ P G++VL V A D D GINA+I Y+ + I E Q F ++ +TG +TT LD
Sbjct: 254 NLPAGSSVLKVMAIDMDEGINAEIIYAFIN-IGKEV----RQLFKLDSKTGELTTIGELD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A+DGG + ++IS D NDN P + +I EDA +GT+V
Sbjct: 309 FEERDSYTIGVEAKDGGHHTAYCKVQIDIS--DENDNAPEITLASESQHIQEDAELGTAV 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV-IRTNKALDRESVATHDLKAVA 659
+ + D D G NG I +L K V D + + T+ ALDRE + +++ A
Sbjct: 367 ALIKTHDLDSGFNGEILCQL--KGNFPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITA 424
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G PP SS+ + + I D+ND+ PVF T +++EN+P G +I +RA DPD GPN
Sbjct: 425 TDKGNPPLSSSKTITLHILDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASDPDLGPN 484
Query: 720 AVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLW 775
+V Y I D + S + + D+E R +EL ++A SP L
Sbjct: 485 GLVSYYIVASDLEPRELSSYVSVSARSGVVFAQRAFDHEQLR-AFELTLQARDQGSPTLS 543
Query: 776 NDVRVEILVTDVNDNAPVM------KDFQIIFNNY-KDCFPVGPFGRVPAYDAD--VTDK 826
+V + +LV D NDNAP++ + +F+ + P +V A DAD
Sbjct: 544 ANVSLRVLVDDRNDNAPLVLYPALGPEGSALFDMVPRSAEPGYLVTKVVAVDADSGYNAW 603
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y I+ + L L TG + + L + V+V DG
Sbjct: 604 LSYHIVQASEPGLFSLGLRTGEVRTARTLGDREAARQRLLVTVRDG 649
Score = 155 bits (375), Expect = 3e-36
Identities = 130/467 (27%), Positives = 209/467 (44%), Gaps = 40/467 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND+ PVF Y +V E +G++VL + A D D G NAE+ Y + +
Sbjct: 229 RVIVADANDNPPVFTQDMYRVNVAENLPAGSSVLKVMAIDMDEGINAEIIYAFINIGKE- 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+ +F++D ++G L T LD E+ YT+ V+A D
Sbjct: 288 ----------------VRQLFKLDSKTGELTTIGELDFEERDSYTIGVEAKD-----GGH 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + ++I D+NDN P+ + + + + ED + +A IK D D G N I
Sbjct: 327 HTAYCKVQIDISDENDNAPEITLASESQHIQEDAEL--GTAVALIKTHDLDSGFNGEI-L 383
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ GN + + LV LD EQ+ Y + I A D G+P S++ + ++I
Sbjct: 384 CQLKGNFPFKI-VQDTKNTYRLVTDGALDREQIPEYNVTITATDKGNPPLSSSKTITLHI 442
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY-TGNVD 306
DVNDN P F+ + + V+EN P G SI V+A D D G N ++Y + D +
Sbjct: 443 LDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASDPDLGPNGLVSYYIVASDLEPRELS 502
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ RSG V+ D E ++L + A D G P SA +
Sbjct: 503 SYVSVSARSGVVFAQRAFDHEQLRAFELTLQARDQGSPTLSANVSLRVLVDDRNDNAPLV 562
Query: 367 M-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ P G L + P PG V + A DAD L Y I + G FS+ +
Sbjct: 563 LYPALGPEGSALFDMVPRSAEPGYLVTKVVAVDADSGYNAWLSYHIVQASEPGLFSLGLR 622
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANN 464
G + A+ L ++ R L V+ D G + +A V +++ A++
Sbjct: 623 TGE--VRTARTLGDREAARQRLLVTVRDGGQQPLSATVMLHLIFADS 667
Score = 74.9 bits (176), Expect = 4e-12
Identities = 68/256 (26%), Positives = 106/256 (41%), Gaps = 11/256 (4%)
Query: 626 EEGSFVIDPASGVIRTNKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSP 684
E+ F + P +G + + +DRE + V + + V + I+DIND+P
Sbjct: 71 EKKFFTVSPENGNLLVSDRIDREEICGKKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNP 130
Query: 685 PVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSD 744
P F + ISE + G T A DPD G N++ Y + + E GS
Sbjct: 131 PTFSQNITELEISELALTGATFALESAQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSR 190
Query: 745 KAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIF 801
ELV LD E + + LV+ A P ++ ++V D NDN PV +
Sbjct: 191 YPELVLKAPLDREE-QPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQ-DMYR 248
Query: 802 NNYKDCFPVG-PFGRVPAYDAD--VTDKLQYRILS-GNNA-NLILLNETTGSMTLSPQLN 856
N + P G +V A D D + ++ Y ++ G L L+ TG +T +L+
Sbjct: 249 VNVAENLPAGSSVLKVMAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELD 308
Query: 857 TNVPKLATMEVSVTDG 872
T+ V DG
Sbjct: 309 FEERDSYTIGVEAKDG 324
>AF152332-1|AAD43726.1| 929|Homo sapiens protocadherin gamma B3
protein.
Length = 929
Score = 227 bits (556), Expect = 3e-58
Identities = 175/607 (28%), Positives = 287/607 (47%), Gaps = 32/607 (5%)
Query: 90 FRIDGRSGALLTRASLDREKVA-RYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
F + +G LL +DRE++ + + V + V+++ + + V I D NDN P
Sbjct: 75 FTVSPENGNLLVSDRIDREEICGKKSTCVLEFEM---VAEKPLNFFHVTVLIQDINDNPP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
FS+ + + E +++T A A D DVG NS +Y + ++L G
Sbjct: 132 TFSQNITELEISE-LALT-GATFALESAQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGS 189
Query: 208 ---DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++ L LD E+ + LV+ A DGG PSRS TTQ+ + + D NDN P F +++
Sbjct: 190 RYPELVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRV 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
+V+EN+P G S+++V A D DEG+NAE+ Y + V +D ++G + T G+L
Sbjct: 250 NVAENLPAGSSVLKVMAIDMDEGINAEIIYAFI--NIGKEVRQLFKLDSKTGELTTIGEL 307
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E + Y + V A DGG +A + ED GT
Sbjct: 308 DFEERDSYTIGVEAKDGGH--HTAYCKVQIDISDENDNAPEITLASESQHIQEDAELGTA 365
Query: 385 VVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVS 442
V + D D + + ++ GN + ++N L+T LD +Q Y +T++
Sbjct: 366 VALIKTHDLDSGFNGEILCQLK-GNFPFKIVQDTKNTYRLVTDG-ALDREQIPEYNVTIT 423
Query: 443 ATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
ATD G S + + ++I D N+ PVF A YT V E+ P G ++ V A+D D+G
Sbjct: 424 ATDKGNPPLSSSKTITLHILDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASDPDLGP 483
Query: 501 NAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
N ++Y + +S++ ++ + ++ ++G + + D E + + LT+ ARD G P
Sbjct: 484 NGLVSYYIVASDLEPRELSSY---VSVSARSGVVFAQRAFDHEQLRAFELTLQARDQGSP 540
Query: 560 SLSDTTDVEISVVDVNDNEPVF-------KQQLYTANIMEDALVGTSVSQVGATDADVGL 612
+LS + + V D NDN P+ + + A G V++V A DAD G
Sbjct: 541 TLSANVSLRVLVDDRNDNAPLVLYPALGPEGSALFDMVPRSAEPGYLVTKVVAVDADSGY 600
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI 672
N + Y + + E G F + +G +RT + L A L DGG P S+TV+
Sbjct: 601 NAWLSYHI-VQASEPGLFSLGLRTGEVRTARTLGDREAARQRLLVTVRDGGQQPLSATVM 659
Query: 673 VHIKIED 679
+H+ D
Sbjct: 660 LHLIFAD 666
Score = 208 bits (509), Expect = 2e-52
Identities = 172/585 (29%), Positives = 272/585 (46%), Gaps = 55/585 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + + D ND+ P F E + E A +G T A D D+G N+ +Y
Sbjct: 118 HVTVLIQDINDNPPTFSQNITELEISELALTGATFALESAQDPDVGVNSLQQY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPV 126
L+P+ +Q +DG R L+ +A LDRE+ + +++ A D P
Sbjct: 171 -YLSPDP-------HFSLIQKE-NLDGSRYPELVLKAPLDREEQPHHHLVLTAVDGGEP- 220
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
S T I V + D NDN P F++ Y V+V E++ + + K+ A D D G N+
Sbjct: 221 --SRSCTTQIRVIVADANDNPPVFTQDMYRVNVAENLPAGSS--VLKVMAIDMDEGINAE 276
Query: 187 IRYAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
I YA IG + F +DS +G+++ + LD+E+ SY + + A+DGG + Q
Sbjct: 277 IIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTIGVEAKDGGHHTAYCKVQ-- 334
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
I+I D NDNAP + + + E+ +G ++ ++ +D D G N E+ + GN
Sbjct: 335 IDISDENDNAPEITLASESQHIQEDAELGTAVALIKTHDLDSGFNGEILCQL-----KGN 389
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
I D ++ + + T G LDRE +Y + +TATD G+PP S++ T
Sbjct: 390 FPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITATDKGNPPLSSSKTITLHILDVNDNV 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGR--FSITSQNG 419
F Y V +AE+ PPG + + A+D D + + Y I + R S S +
Sbjct: 450 PVFHQASYTVHVAENNPPGASIAHVRASDPDLGPNGLVSYYIVASDLEPRELSSYVSVSA 509
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQIN--ITDANNYAPVF---ENAP 473
R G++ + D +Q R + LT+ A D G + +A V + + D N+ AP+ P
Sbjct: 510 RSGVVFAQRAFDHEQLRAFELTLQARDQGSPTLSANVSLRVLVDDRNDNAPLVLYPALGP 569
Query: 474 YTASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+++F+ P G V V A D+D G NA ++Y + A F + +
Sbjct: 570 EGSALFDMVPRSAEPGYLVTKVVAVDADSGYNAWLSYHI-------VQASEPGLFSLGLR 622
Query: 530 TGAITTNKLL-DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T + L DRE LL VT RDGG LS T + + D
Sbjct: 623 TGEVRTARTLGDREAARQRLL-VTVRDGGQQPLSATVMLHLIFAD 666
Score = 202 bits (494), Expect = 1e-50
Identities = 150/466 (32%), Positives = 228/466 (48%), Gaps = 26/466 (5%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + PLD +++ + L ++A D G RS T +++ + DAN+ PVF Y +V E
Sbjct: 194 LVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRVNVAE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ P G++VL V A D D GINA+I Y+ + I E Q F ++ +TG +TT LD
Sbjct: 254 NLPAGSSVLKVMAIDMDEGINAEIIYAFIN-IGKEV----RQLFKLDSKTGELTTIGELD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A+DGG + ++IS D NDN P + +I EDA +GT+V
Sbjct: 309 FEERDSYTIGVEAKDGGHHTAYCKVQIDIS--DENDNAPEITLASESQHIQEDAELGTAV 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV-IRTNKALDRESVATHDLKAVA 659
+ + D D G NG I +L K V D + + T+ ALDRE + +++ A
Sbjct: 367 ALIKTHDLDSGFNGEILCQL--KGNFPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITA 424
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
D G PP SS+ + + I D+ND+ PVF T +++EN+P G +I +RA DPD GPN
Sbjct: 425 TDKGNPPLSSSKTITLHILDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASDPDLGPN 484
Query: 720 AVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLW 775
+V Y I D + S + + D+E R +EL ++A SP L
Sbjct: 485 GLVSYYIVASDLEPRELSSYVSVSARSGVVFAQRAFDHEQLR-AFELTLQARDQGSPTLS 543
Query: 776 NDVRVEILVTDVNDNAPVM------KDFQIIFNNY-KDCFPVGPFGRVPAYDAD--VTDK 826
+V + +LV D NDNAP++ + +F+ + P +V A DAD
Sbjct: 544 ANVSLRVLVDDRNDNAPLVLYPALGPEGSALFDMVPRSAEPGYLVTKVVAVDADSGYNAW 603
Query: 827 LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
L Y I+ + L L TG + + L + V+V DG
Sbjct: 604 LSYHIVQASEPGLFSLGLRTGEVRTARTLGDREAARQRLLVTVRDG 649
Score = 155 bits (375), Expect = 3e-36
Identities = 130/467 (27%), Positives = 209/467 (44%), Gaps = 40/467 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND+ PVF Y +V E +G++VL + A D D G NAE+ Y + +
Sbjct: 229 RVIVADANDNPPVFTQDMYRVNVAENLPAGSSVLKVMAIDMDEGINAEIIYAFINIGKE- 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+ +F++D ++G L T LD E+ YT+ V+A D
Sbjct: 288 ----------------VRQLFKLDSKTGELTTIGELDFEERDSYTIGVEAKD-----GGH 326
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + ++I D+NDN P+ + + + + ED + +A IK D D G N I
Sbjct: 327 HTAYCKVQIDISDENDNAPEITLASESQHIQEDAEL--GTAVALIKTHDLDSGFNGEI-L 383
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
+ GN + + LV LD EQ+ Y + I A D G+P S++ + ++I
Sbjct: 384 CQLKGNFPFKI-VQDTKNTYRLVTDGALDREQIPEYNVTITATDKGNPPLSSSKTITLHI 442
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY-TGNVD 306
DVNDN P F+ + + V+EN P G SI V+A D D G N ++Y + D +
Sbjct: 443 LDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASDPDLGPNGLVSYYIVASDLEPRELS 502
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
+++ RSG V+ D E ++L + A D G P SA +
Sbjct: 503 SYVSVSARSGVVFAQRAFDHEQLRAFELTLQARDQGSPTLSANVSLRVLVDDRNDNAPLV 562
Query: 367 M-P--GQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ P G L + P PG V + A DAD L Y I + G FS+ +
Sbjct: 563 LYPALGPEGSALFDMVPRSAEPGYLVTKVVAVDADSGYNAWLSYHIVQASEPGLFSLGLR 622
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANN 464
G + A+ L ++ R L V+ D G + +A V +++ A++
Sbjct: 623 TGE--VRTARTLGDREAARQRLLVTVRDGGQQPLSATVMLHLIFADS 667
Score = 74.9 bits (176), Expect = 4e-12
Identities = 68/256 (26%), Positives = 106/256 (41%), Gaps = 11/256 (4%)
Query: 626 EEGSFVIDPASGVIRTNKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSP 684
E+ F + P +G + + +DRE + V + + V + I+DIND+P
Sbjct: 71 EKKFFTVSPENGNLLVSDRIDREEICGKKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNP 130
Query: 685 PVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSD 744
P F + ISE + G T A DPD G N++ Y + + E GS
Sbjct: 131 PTFSQNITELEISELALTGATFALESAQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSR 190
Query: 745 KAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIF 801
ELV LD E + + LV+ A P ++ ++V D NDN PV +
Sbjct: 191 YPELVLKAPLDREE-QPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQ-DMYR 248
Query: 802 NNYKDCFPVG-PFGRVPAYDAD--VTDKLQYRILS-GNNA-NLILLNETTGSMTLSPQLN 856
N + P G +V A D D + ++ Y ++ G L L+ TG +T +L+
Sbjct: 249 VNVAENLPAGSSVLKVMAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELD 308
Query: 857 TNVPKLATMEVSVTDG 872
T+ V DG
Sbjct: 309 FEERDSYTIGVEAKDG 324
>BC033735-1|AAH33735.1| 890|Homo sapiens PCDHA5 protein protein.
Length = 890
Score = 226 bits (553), Expect = 8e-58
Identities = 170/617 (27%), Positives = 283/617 (45%), Gaps = 33/617 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ R + + + DR + V + D NDN
Sbjct: 72 DLLEVNLQNGILFVNSRIDREELCRRRA--ECSIHLEVIVDRPLQVFHVEVAVKDINDNP 129
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P+FS + + + E + D+ + A+D D+GAN+ +RY + N F +D +
Sbjct: 130 PRFSRQEQRLFILES-RMPDSRFPLE-GASDLDIGANAQLRYRL---NPNEYFDLDVKTN 184
Query: 208 D-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTS 260
+ + L K+LD E+ + +RL++ A DGG P + T QLLIN+ D ND+AP F S
Sbjct: 185 EEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDSAPEFDKS 244
Query: 261 LFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYT 320
++ + EN P G ++++ A DADEG+N E+ Y ++ +V I+ +G +
Sbjct: 245 IYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNL-VLDDVKSKFIINSNTGEIKV 303
Query: 321 SGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEP 380
+G+LD E Y++ + A D P S + + ED P
Sbjct: 304 NGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAP 363
Query: 381 PGTPVVTLTATDADEDNRLHYEITGG---NTRGRFSITSQNGRGLITVAQPLDFKQERRY 437
T + ++ +D D+ + ++T + + T +N L+ + LD + Y
Sbjct: 364 LSTVIALISV--SDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESVSVY 420
Query: 438 VLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATD 495
L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D
Sbjct: 421 ELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARD 480
Query: 496 SDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARD 555
+D NA ++YSL E ++ ++G + + LD E + V+ARD
Sbjct: 481 ADAQENALVSYSLVERRVGERPL--SSYVSVHAESGKVYALQPLDHEEVELLQFQVSARD 538
Query: 556 GGVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDA 608
GVP L +++ V+D NDN P T + + + G V++V A D
Sbjct: 539 AGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDP 598
Query: 609 DVGLNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ 667
D G N + YEL P F + +G I T ++LD H L + D G PP
Sbjct: 599 DSGYNAWLSYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPL 658
Query: 668 SSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 659 TATATVLVSLVESGQAP 675
Score = 215 bits (524), Expect = 3e-54
Identities = 165/553 (29%), Positives = 249/553 (45%), Gaps = 37/553 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN PRF + + E+ A D D G NA+L Y + +Y
Sbjct: 120 VAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEY--- 176
Query: 305 VDLPI-TIDPRSGWV--YTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
DL + T + + ++ LDRE +++LLV ATDGG P + T
Sbjct: 177 FDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDAND 236
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSITS 416
F Y V L E+ P GT V+ L A+DADE + + Y + + + +F I S
Sbjct: 237 SAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINS 296
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPY 474
G I V LD++ Y + + A D S V + + D N+ P
Sbjct: 297 NTGE--IKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTL 354
Query: 475 TASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAIT 534
V EDAP+ T + ++S +D D G N Q+T SL + + V+ + ++
Sbjct: 355 FLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLV 407
Query: 535 TNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDA 594
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 408 LDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENN 467
Query: 595 LVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESV 650
G + V A DAD N + Y L + +R S+V + SG + + LD E V
Sbjct: 468 PPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEV 527
Query: 651 ATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIG 703
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 528 ELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAG 587
Query: 704 TTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKK 762
+ ++RA DPD G NA + Y ++ S + R G E+ T LD E+PR +
Sbjct: 588 HVVAKVRAVDPDSGYNAWLSYELQPA--PGSARIPFRVGLYTGEISTTRSLDETEAPRHR 645
Query: 763 YELVIR-AASPPL 774
++++ PPL
Sbjct: 646 LLVLVKDHGEPPL 658
Score = 198 bits (484), Expect = 2e-49
Identities = 162/584 (27%), Positives = 258/584 (44%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ P F Q+ + E + A+D DIG NA++ Y
Sbjct: 117 HVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRY------- 169
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
LNP + + L+ R SLDRE+ + +LV ATD P
Sbjct: 170 -RLNPNEYFDLDVKTNEEETNFLE-------LVLRKSLDREETQEHRLLVIATDGGKP-- 219
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + +N++D ND+ P+F + Y V + E + ++ K+ A+DAD G N I
Sbjct: 220 -ELTGTVQLLINVLDANDSAPEFDKSIYNVRLLE--NAPSGTLVIKLNASDADEGINKEI 276
Query: 188 RY---AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y ++ + + +F I+S +G++ + LDYE SY + I A D + S +++
Sbjct: 277 VYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVV 336
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDN P + V E+ P+ I + D D G N ++T ++ +
Sbjct: 337 VKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP-----H 391
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 392 VPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNA 451
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNT--RGRFSITSQNG 419
F QY V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 452 PAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHA 511
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 512 ESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGG 571
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ V G V V A D D G NA ++Y L + + F +
Sbjct: 572 TGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARI-----PFRVGLY 626
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G P L+ T V +S+V+
Sbjct: 627 TGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLVE 670
Score = 192 bits (469), Expect = 1e-47
Identities = 119/377 (31%), Positives = 196/377 (51%), Gaps = 10/377 (2%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQ--INITDANNYAPVFENAPYTASVFE 480
+ + + LD ++ + + L V ATD G T VQ IN+ DAN+ AP F+ + Y + E
Sbjct: 193 LVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDSAPEFDKSIYNVRLLE 252
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP GT V+ ++A+D+D GIN +I Y S+ + ++ + +F+IN TG I N LD
Sbjct: 253 NAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKS----KFIINSNTGEIKVNGELD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E + Y + + A D LS V + ++DVNDN P + EDA + T +
Sbjct: 309 YEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVI 368
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAI 660
+ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 ALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESVSVYELVVTAR 427
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D NA
Sbjct: 428 DGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENA 487
Query: 721 VVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPR-KKYELVIR-AASPPLWND 777
+V YS ++ S ++ ++ + LD+E ++++ R A PPL ++
Sbjct: 488 LVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSN 547
Query: 778 VRVEILVTDVNDNAPVM 794
V +++ V D NDNAP +
Sbjct: 548 VTLQVFVLDENDNAPAL 564
Score = 55.2 bits (127), Expect = 3e-06
Identities = 66/281 (23%), Positives = 123/281 (43%), Gaps = 18/281 (6%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV-IDPASGVIRTNKALDR 647
+I E+A GT V ++ A D + L + + G + ++ +G++ N +DR
Sbjct: 33 SIPEEAKHGTFVGRI-AQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDR 91
Query: 648 ESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTI 706
E + + ++ ++ V + ++DIND+PP F +I E+ +
Sbjct: 92 EELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRF 151
Query: 707 GEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKY 763
A D D G NA + Y + + + F L+ + ++ ELV LD E ++
Sbjct: 152 PLEGASDLDIGANAQLRYRL---NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHR 208
Query: 764 ELVIR--AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG-RVPAYD 820
LVI P L V++ I V D ND+AP D I + P G ++ A D
Sbjct: 209 LLVIATDGGKPELTGTVQLLINVLDANDSAPEF-DKSIYNVRLLENAPSGTLVIKLNASD 267
Query: 821 AD--VTDKLQY---RILSGNNANLILLNETTGSMTLSPQLN 856
AD + ++ Y ++ + + ++N TG + ++ +L+
Sbjct: 268 ADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELD 308
>AF217748-1|AAK51616.1| 800|Homo sapiens protocadherin-beta10
protein.
Length = 800
Score = 225 bits (550), Expect = 2e-57
Identities = 185/604 (30%), Positives = 268/604 (44%), Gaps = 32/604 (5%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 77 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVRDINDHAPVFQ 134
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSL 211
+K + + E+ + + +A D D G N Y I + F I+ GD +
Sbjct: 135 DKETVLKISENTA--EGTAFRLERAQDPDGGLNGIQNYTI---SPNSFFHINISGGDEGM 189
Query: 212 V-------KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
+ K LD E+ L + A DGGSPSRS T+ + I + DVNDNAP+F +L++
Sbjct: 190 IYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYET 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
EN PIG+ IV+V A D D GVNAE++Y+ D + N+ I+P SG ++ L
Sbjct: 250 QAPENSPIGFLIVKVWAEDVDSGVNAEVSYSFFDA--SENIRTTFQINPFSGEIFLRELL 307
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ + A DGG SA + + +AE+ P TP
Sbjct: 308 DYELVNSYKINIQAMDGGG--LSARCRVLVEVLDTNDNPPELIVSSFSNSVAENSPE-TP 364
Query: 385 VVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ D D +N N + +N LIT LD + Y +T++
Sbjct: 365 LAVFKINDRDSGENGKMVCYIQENLPFLLKPSVENFYILITEG-ALDREIRAEYNITITV 423
Query: 444 TDSG-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G R T + + ++D N+ AP F YT V E+ + VSATD D G N
Sbjct: 424 TDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTN 483
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
AQ+TYSL + IN G + + LD E + + V A D G P+L
Sbjct: 484 AQVTYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPAL 541
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGR 615
S V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 542 SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW 601
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +H+
Sbjct: 602 LSYQL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHV 660
Query: 676 KIED 679
+ D
Sbjct: 661 LLVD 664
Score = 190 bits (462), Expect = 8e-47
Identities = 165/594 (27%), Positives = 259/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDH+PVF+ ++ + E + GT +A D D G N
Sbjct: 110 MDDPFQIYRAELRVRDINDHAPVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQN 169
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + +N L+ +LDRE+ ++ + A
Sbjct: 170 YTISPNSFFHINISGGDEGMIY---------------PELVLDKALDREEQGELSLTLTA 214
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+T+ + ++D NDN PQF++ Y E+ + +I K+ A D
Sbjct: 215 LDGGSP---SRSGTSTVRIVVLDVNDNAPQFAQALYETQAPENSPI--GFLIVKVWAEDV 269
Query: 180 DVGANSAIRYAIIGG--NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ N + F I+ SG++ L + LDYE V SY++ I+A DGG
Sbjct: 270 DSGVNAEVSYSFFDASENIRTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGG--GL 327
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
S ++L+ + D NDN P S F SV+EN P + + D D G N ++ +
Sbjct: 328 SARCRVLVEVLDTNDNPPELIVSSFSNSVAENSP-ETPLAVFKINDRDSGENGKMVCYIQ 386
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ +LP + P Y T G LDRE +A+Y + +T TD G P
Sbjct: 387 E-------NLPFLLKPSVENFYILITEGALDREIRAEYNITITVTDLGTPRLKTEHNITV 439
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 440 LVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 499
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V ATD G S A+V++ + DAN+
Sbjct: 500 LASLVSINADNGH--LFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDN 557
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 558 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 610
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 168 bits (408), Expect = 3e-40
Identities = 122/406 (30%), Positives = 196/406 (48%), Gaps = 24/406 (5%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +++ LT++A D G RS T+ V+I + D N+ AP F A Y E
Sbjct: 194 LVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYETQAPE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
++PIG ++ V A D D G+NA+++YS N F INP +G I +LLD
Sbjct: 254 NSPIGFLIVKVWAEDVDSGVNAEVSYSFFDASENIRTT-----FQINPFSGEIFLRELLD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E ++ Y + + A DGG LS V + V+D NDN P ++ ++ E++ T +
Sbjct: 309 YELVNSYKINIQAMDGG--GLSARCRVLVEVLDTNDNPPELIVSSFSNSVAENS-PETPL 365
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ D D G NG++ + +E F++ P+ ++ T ALDRE A +++
Sbjct: 366 AVFKINDRDSGENGKMVCYI----QENLPFLLKPSVENFYILITEGALDREIRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + D+ND+ P F T ++ EN+ IG + A D D G
Sbjct: 422 TVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
NA V YS+ D + + +D L + LDYE+ + +E + A SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFEFRVGATDRGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V +LV D NDN+P + + N C + P P Y
Sbjct: 541 LSSEALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 107 bits (256), Expect = 7e-22
Identities = 90/279 (32%), Positives = 127/279 (45%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 73 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVRDINDHA 130
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D GLNG +Y + P + + G+
Sbjct: 131 PVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQNYTISPNSFFHIN-ISGGDEGM 189
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T V I + D+ND+ P F
Sbjct: 190 IYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYET 249
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSPIG I ++ A D D G NA V YS D S + + E+ L
Sbjct: 250 QAPENSPIGFLIVKVWAEDVDSGVNAEVSYSF--FDASENIRTTFQINPFSGEIFLRELL 307
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L RV + V D NDN P
Sbjct: 308 DYELV-NSYKINIQAMDGGGLSARCRVLVEVLDTNDNPP 345
Score = 63.7 bits (148), Expect = 9e-09
Identities = 53/176 (30%), Positives = 77/176 (43%), Gaps = 11/176 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 69 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDIND 128
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF+ ISEN+ GT RA DPD G N + +Y+I NSF G
Sbjct: 129 HAPVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQNYTI----SPNSFFHINISG 184
Query: 743 SDKAELVTMVDLDYESPRKKY-EL-----VIRAASPPLWNDVRVEILVTDVNDNAP 792
D+ + + LD R++ EL + SP V I+V DVNDNAP
Sbjct: 185 GDEGMIYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAP 240
>AF152514-1|AAD43774.1| 817|Homo sapiens protocadherin gamma A7
short form protein protein.
Length = 817
Score = 225 bits (550), Expect = 2e-57
Identities = 187/609 (30%), Positives = 283/609 (46%), Gaps = 34/609 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + + D+++ I V IID NDN P
Sbjct: 74 LFALNQRSGSLVTAGRIDREEICAQSARCLVNFNIL-MEDKMN-LYPIDVEIIDINDNVP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGD 208
+F + V + E+ + +++ A D DVG NS Y + + FS+ SGD
Sbjct: 132 RFLTEEINVKIMENTAPGVRFPLSE--AGDPDVGTNSLQSYQL---SPNRHFSLAVQSGD 186
Query: 209 -------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
+ L + LD E+ R + LV+ A DGG P RS+T + + + DVND+ P F
Sbjct: 187 DETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQ 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+Q +V ENVP+G ++ V A D DEGVN E+TY+ + T + ++ +G + T
Sbjct: 247 YQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSF--RKITPKLPKMFHLNSLTGEISTL 304
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E A Y++ V A DG P A + ED P
Sbjct: 305 EGLDYEETAFYEMEVQAQDG--PGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPL 362
Query: 382 GTPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + D D T N + + N L+T + LD + Y +T
Sbjct: 363 GTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVT-TKNLDRETLSLYNIT 421
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
+ ATD G S + + + D N+ P F ++ Y+ + E+ P G ++ +V+A D D
Sbjct: 422 LKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDS 481
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NAQITYSL+ + A IN TG + + D E + L VTA D G
Sbjct: 482 EDNAQITYSLAEDTIQGAPV--SSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGD 539
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYT--ANIME----DALVGTSVSQVGATDADVG 611
P LS + + V+D NDN P + L T + ME A G V++V A D D G
Sbjct: 540 PPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSG 599
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSST 670
N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+T
Sbjct: 600 QNAWLSYLL-LKASEPGLFAVGLYTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSAT 657
Query: 671 VIVHIKIED 679
V + + + D
Sbjct: 658 VTLTVAVAD 666
Score = 194 bits (473), Expect = 4e-48
Identities = 137/439 (31%), Positives = 216/439 (49%), Gaps = 23/439 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL- 422
F+ + V++ E+ PG A D D N L Y+++ FS+ Q+G
Sbjct: 133 FLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNR---HFSLAVQSGDDET 189
Query: 423 ----ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
+ + + LD ++ER + L ++A+D G RS TA +Q+ + D N++ PVF Y
Sbjct: 190 KYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+V E+ P+GT +L V A D D G+N ++TYS + + F +N TG I+T
Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSF-----RKITPKLPKMFHLNSLTGEISTL 304
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LD E + Y + V A+DG P V I+V+DVNDN P +++I ED +
Sbjct: 305 EGLDYEETAFYEMEVQAQDG--PGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPL 362
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
GT ++ D D G NG + + + ID ++ T K LDRE+++ +++
Sbjct: 363 GTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLV-TTKNLDRETLSLYNIT 421
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
A DGGTPP S + +++ D ND+PP F + YI+EN+P G +I + A D D
Sbjct: 422 LKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDS 481
Query: 717 GPNAVVHYSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPRKKYELVIR--AASPP 773
NA + YS+ + S SD L + DYE R+ V + PP
Sbjct: 482 EDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPP 541
Query: 774 LWNDVRVEILVTDVNDNAP 792
L +++ + + V D NDN P
Sbjct: 542 LSSNMSLSLFVLDQNDNPP 560
Score = 169 bits (412), Expect = 9e-41
Identities = 138/472 (29%), Positives = 216/472 (45%), Gaps = 38/472 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H Q+ V+D NDH+PVF + QY+ +V E GT +LT+ A D D G N EV Y+ +T
Sbjct: 227 HIQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKIT- 285
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
P+ + +F ++ +G + T LD E+ A Y + V+A D P S
Sbjct: 286 ----PK------------LPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQD--GPGS 327
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
+ A + + ++D NDN P+ + + + S+ ED + VIA D D G N +
Sbjct: 328 ---LTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPL--GTVIALFYLQDRDSGKNGEV 382
Query: 188 RYAIIGG-NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I +++ SID+ V+ K LD E + Y + ++A DGG+P S T + +
Sbjct: 383 TCTIPENLPFKLEKSIDNYYRLVT-TKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQ 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ D NDN P F S + ++EN P G SI V A D D NA++TY++ + G V
Sbjct: 442 VADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPV 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E + QL VTA D GDPP S+ +
Sbjct: 502 SSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPE 561
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G +ELA PG V + A D D L Y + + G F++
Sbjct: 562 ILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A++ V
Sbjct: 622 YTGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEV 671
Score = 74.1 bits (174), Expect = 6e-12
Identities = 83/302 (27%), Positives = 132/302 (43%), Gaps = 25/302 (8%)
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGS---FVIDPASGVIRTNKALDRESVATHDLKA 657
S VG D+GL R E + G F ++ SG + T +DRE + +
Sbjct: 43 SFVGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARC 102
Query: 658 -VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
V + + + + ++I DIND+ P F ++ + I EN+ G A DPD
Sbjct: 103 LVNFNILMEDKMNLYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDV 162
Query: 717 GPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKYELVIRAA--- 770
G N++ Y + + FSL + G D+ ELV LD E R + LV+ A+
Sbjct: 163 GTNSLQSYQL---SPNRHFSLAVQSGDDETKYPELVLERVLDREEER-VHHLVLTASDGG 218
Query: 771 SPPLWNDVRVEILVTDVNDNAPV--MKDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTD 825
PP + +++ V DVND+ PV + +Q+ + PVG V A D D V
Sbjct: 219 DPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV---TVPENVPVGTRLLTVHAIDLDEGVNG 275
Query: 826 KLQY--RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEI-KAMMQL 882
++ Y R ++ + LN TG ++ L+ MEV DG + KA + +
Sbjct: 276 EVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLI 335
Query: 883 SV 884
+V
Sbjct: 336 TV 337
>AF152479-1|AAD43740.1| 807|Homo sapiens protocadherin alpha 1
short form protein protein.
Length = 807
Score = 225 bits (550), Expect = 2e-57
Identities = 170/619 (27%), Positives = 282/619 (45%), Gaps = 35/619 (5%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ ++ ++G L + +DRE++ +++ + + ++DR + V + D NDN
Sbjct: 72 RDLLEVNLQNGILFVNSRIDREELCQWSA--ECSIHLELIADRPLQVFHVEVKVKDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
P F + + + E + I A DAD+GAN+ + Y + + FS+D +
Sbjct: 130 PPVFRGREQIIFIPESRLLNSRFPIEG--AADADIGANALLTYTLSPSD---YFSLDVEA 184
Query: 207 GD-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
D + L K LD E+ L++ A DGG P T +LLI + DVNDNAP F
Sbjct: 185 SDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ 244
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
++++ + E G + + A DADEGVN E+ ++ D + ++ +D SG +
Sbjct: 245 AVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSF-DSGISRDIQEKFKVDSSSGEIR 303
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
+LD E Y++ V A D G PP S + + ED
Sbjct: 304 LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDA 363
Query: 380 PPGTPVVTLTATDADEDNRLHYEITGG---NTRGRFSITSQNGRGLITVAQPLDFKQERR 436
P T + +T +D D+ + ++T + + T +N L+ + LD +
Sbjct: 364 PLSTVIALITVSD--RDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESLSV 420
Query: 437 YVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSAT 494
Y L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 495 DSDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D+D NA ++YSL + A++++ ++ ++G + + LD E + V+A
Sbjct: 481 DADAQENALVSYSLVERRVGERALSNYVS---VHAESGKVYALQPLDHEELELLQFQVSA 537
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI-----MEDALVGTS--VSQVGAT 606
RD GVP L +++ V+D NDN P I + LVG V++V A
Sbjct: 538 RDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHVVAKVRAV 597
Query: 607 DADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G N + YEL P F + +G I T + LD ++ + L + D G P
Sbjct: 598 DADSGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEP 657
Query: 666 PQSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 658 ALTATATVLVSLVESGQAP 676
Score = 222 bits (543), Expect = 1e-56
Identities = 171/587 (29%), Positives = 272/587 (46%), Gaps = 54/587 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ PVF ++ + E + A D DIG NA + YT
Sbjct: 118 HVEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYT------ 171
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P D + +S L R LDRE+ +L+ ATD P
Sbjct: 172 --LSPSDYFSLDVEASDELS-------KSLWLELRKYLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L T + + ++D NDN P F + Y V + E + + ++ + A+DAD G N +
Sbjct: 221 -ELQGTVELLITVLDVNDNAPLFDQAVYRVHLLE--TTANGTLVTTLNASDADEGVNGEV 277
Query: 188 RYAIIGG---NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
++ G + Q +F +DS SG++ L+ LDYE+ +SY + ++A D GSP SN ++L
Sbjct: 278 VFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP + + E+ P+ I + D D G N ++T ++ +
Sbjct: 338 VKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGR-----FSITS 416
F +Y V + E+ PPG + T++A DAD ++N L Y + R S+ +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHA 512
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
++G+ + QPLD ++ VSA D+G +Q+ + D N+ AP AP
Sbjct: 513 ESGK--VYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL-LAPR 569
Query: 475 T----ASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
+V E P G V V A D+D G NA ++Y L + F +
Sbjct: 570 VGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARI-----PFRV 624
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T ++LD +S Y L V +D G P+L+ T V +S+V+
Sbjct: 625 GLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 219 bits (534), Expect = 2e-55
Identities = 164/542 (30%), Positives = 251/542 (46%), Gaps = 32/542 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + E+ + A DAD G NA LTYT++ DY +
Sbjct: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF-S 179
Query: 305 VDLPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + + +S W+ LDRE + LL+TATDGG P T
Sbjct: 180 LDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRG---RFSITSQN 418
F Y V L E GT V TL A+DADE + + + G +R +F + S +
Sbjct: 240 PLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G I + LD+++ + Y + V A D G S+ V + + D N+ AP
Sbjct: 300 GE--IRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ EDAP+ T + +++ +D D G N Q+T SL + + V+ + ++ +
Sbjct: 358 PIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R ++V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL---TFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
+ ++RA D D G NA + Y ++ + + R G E+ T LD E+ +Y L
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPA--AGGARIPFRVGLYTGEISTTRVLD-EADLSRYRL 647
Query: 766 VI 767
++
Sbjct: 648 LV 649
Score = 182 bits (443), Expect = 2e-44
Identities = 141/450 (31%), Positives = 218/450 (48%), Gaps = 25/450 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V++ + D N+ PVF + E + + + A D+D+G NA +TY+LS S+
Sbjct: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ V D+ ++ + K LDRE L +TA DGG P L T ++ I+V+D
Sbjct: 179 SLDVEASDEL----SKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD---PKDREEGSF 630
VNDN P+F Q +Y +++E GT V+ + A+DAD G+NG + + D +D +E F
Sbjct: 235 VNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQE-KF 293
Query: 631 VIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESD 690
+D +SG IR LD E +++++ A+D G+PP S+ V +K+ D+ND+ P
Sbjct: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVT 353
Query: 691 CLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVT 750
L I E++P+ T I I D D G N V S+ F L + LV
Sbjct: 354 SLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLM---PHVPFKL-VSTFKNYYSLVL 409
Query: 751 MVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDC 807
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 410 DSALDRES-LSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENN 468
Query: 808 FPVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVP 860
P V A DAD + + Y ++ G A N + ++ +G + L+
Sbjct: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEEL 528
Query: 861 KLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+L +VS D GV + + + L V ++ E
Sbjct: 529 ELLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 176 bits (428), Expect = 1e-42
Identities = 113/371 (30%), Positives = 188/371 (50%), Gaps = 10/371 (2%)
Query: 429 LDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGT 486
LD ++ L ++ATD G V++ IT D N+ AP+F+ A Y + E GT
Sbjct: 200 LDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGT 259
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
V ++A+D+D G+N ++ +S S IS + ++F ++ +G I LD E
Sbjct: 260 LVTTLNASDADEGVNGEVVFSFDSGISRDI----QEKFKVDSSSGEIRLIDKLDYEETKS 315
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
Y + V A D G P +S+ V + V+DVNDN P I EDA + T ++ + +
Sbjct: 316 YEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVS 375
Query: 607 DADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
D D G NG++ L P + ++ + ALDRES++ ++L A DGG+P
Sbjct: 376 DRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESLSVYELVVTARDGGSPS 434
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYS- 725
+T V +++ D+ND+ P F T ++ EN+P G I + A D D NA+V YS
Sbjct: 435 LWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Query: 726 IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWNDVRVEIL 783
++ + S ++ ++ + LD+E ++++ R A PPL ++V +++
Sbjct: 495 VERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 784 VTDVNDNAPVM 794
V D NDNAP +
Sbjct: 555 VLDENDNAPAL 565
Score = 128 bits (310), Expect = 2e-28
Identities = 101/324 (31%), Positives = 146/324 (45%), Gaps = 17/324 (5%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
S+ E+A GT V V+ D+G+ L + A H +N Q G + N
Sbjct: 34 SIPEEAKHGTFVGRVA---QDLGLELA---ELVPRLFRVASKTHRDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + + + + VE+ V D+NDN PVF+ + I E L
Sbjct: 88 SRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDNPPVFRGREQIIFIPESRL 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD----REEGSFVIDPASGVIRTNKALDRESVA 651
+ + GA DAD+G N + Y L P D E S + S + K LDRE
Sbjct: 148 LNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELS-KSLWLELRKYLDREETP 206
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
L A DGG P TV + I + D+ND+ P+F+ ++ E + GT + + A
Sbjct: 207 ELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNA 266
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA-- 769
D DEG N V +S G S + + S E+ + LDYE K YE+ ++A
Sbjct: 267 SDADEGVNGEVVFSFDSG-ISRDIQEKFKVDSSSGEIRLIDKLDYEE-TKSYEIQVKAVD 324
Query: 770 -ASPPLWNDVRVEILVTDVNDNAP 792
SPP+ N +V + V DVNDNAP
Sbjct: 325 KGSPPMSNHCKVLVKVLDVNDNAP 348
>AF152327-1|AAD43721.1| 932|Homo sapiens protocadherin gamma A7
protein.
Length = 932
Score = 225 bits (550), Expect = 2e-57
Identities = 187/609 (30%), Positives = 283/609 (46%), Gaps = 34/609 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + + D+++ I V IID NDN P
Sbjct: 74 LFALNQRSGSLVTAGRIDREEICAQSARCLVNFNIL-MEDKMN-LYPIDVEIIDINDNVP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGD 208
+F + V + E+ + +++ A D DVG NS Y + + FS+ SGD
Sbjct: 132 RFLTEEINVKIMENTAPGVRFPLSE--AGDPDVGTNSLQSYQL---SPNRHFSLAVQSGD 186
Query: 209 -------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
+ L + LD E+ R + LV+ A DGG P RS+T + + + DVND+ P F
Sbjct: 187 DETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQ 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+Q +V ENVP+G ++ V A D DEGVN E+TY+ + T + ++ +G + T
Sbjct: 247 YQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSF--RKITPKLPKMFHLNSLTGEISTL 304
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E A Y++ V A DG P A + ED P
Sbjct: 305 EGLDYEETAFYEMEVQAQDG--PGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPL 362
Query: 382 GTPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + D D T N + + N L+T + LD + Y +T
Sbjct: 363 GTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVT-TKNLDRETLSLYNIT 421
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
+ ATD G S + + + D N+ P F ++ Y+ + E+ P G ++ +V+A D D
Sbjct: 422 LKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDS 481
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NAQITYSL+ + A IN TG + + D E + L VTA D G
Sbjct: 482 EDNAQITYSLAEDTIQGAPV--SSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGD 539
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYT--ANIME----DALVGTSVSQVGATDADVG 611
P LS + + V+D NDN P + L T + ME A G V++V A D D G
Sbjct: 540 PPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSG 599
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSST 670
N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+T
Sbjct: 600 QNAWLSYLL-LKASEPGLFAVGLYTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSAT 657
Query: 671 VIVHIKIED 679
V + + + D
Sbjct: 658 VTLTVAVAD 666
Score = 194 bits (473), Expect = 4e-48
Identities = 137/439 (31%), Positives = 216/439 (49%), Gaps = 23/439 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRGL- 422
F+ + V++ E+ PG A D D N L Y+++ FS+ Q+G
Sbjct: 133 FLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNR---HFSLAVQSGDDET 189
Query: 423 ----ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
+ + + LD ++ER + L ++A+D G RS TA +Q+ + D N++ PVF Y
Sbjct: 190 KYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+V E+ P+GT +L V A D D G+N ++TYS + + F +N TG I+T
Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSF-----RKITPKLPKMFHLNSLTGEISTL 304
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LD E + Y + V A+DG P V I+V+DVNDN P +++I ED +
Sbjct: 305 EGLDYEETAFYEMEVQAQDG--PGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPL 362
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
GT ++ D D G NG + + + ID ++ T K LDRE+++ +++
Sbjct: 363 GTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLV-TTKNLDRETLSLYNIT 421
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
A DGGTPP S + +++ D ND+PP F + YI+EN+P G +I + A D D
Sbjct: 422 LKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDS 481
Query: 717 GPNAVVHYSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPRKKYELVIR--AASPP 773
NA + YS+ + S SD L + DYE R+ V + PP
Sbjct: 482 EDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPP 541
Query: 774 LWNDVRVEILVTDVNDNAP 792
L +++ + + V D NDN P
Sbjct: 542 LSSNMSLSLFVLDQNDNPP 560
Score = 169 bits (412), Expect = 9e-41
Identities = 138/472 (29%), Positives = 216/472 (45%), Gaps = 38/472 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H Q+ V+D NDH+PVF + QY+ +V E GT +LT+ A D D G N EV Y+ +T
Sbjct: 227 HIQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKIT- 285
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
P+ + +F ++ +G + T LD E+ A Y + V+A D P S
Sbjct: 286 ----PK------------LPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQD--GPGS 327
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
+ A + + ++D NDN P+ + + + S+ ED + VIA D D G N +
Sbjct: 328 ---LTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPL--GTVIALFYLQDRDSGKNGEV 382
Query: 188 RYAIIGG-NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I +++ SID+ V+ K LD E + Y + ++A DGG+P S T + +
Sbjct: 383 TCTIPENLPFKLEKSIDNYYRLVT-TKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQ 441
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ D NDN P F S + ++EN P G SI V A D D NA++TY++ + G V
Sbjct: 442 VADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPV 501
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E + QL VTA D GDPP S+ +
Sbjct: 502 SSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPE 561
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G +ELA PG V + A D D L Y + + G F++
Sbjct: 562 ILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGL 621
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A++ V
Sbjct: 622 YTGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEV 671
Score = 74.1 bits (174), Expect = 6e-12
Identities = 83/302 (27%), Positives = 132/302 (43%), Gaps = 25/302 (8%)
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGS---FVIDPASGVIRTNKALDRESVATHDLKA 657
S VG D+GL R E + G F ++ SG + T +DRE + +
Sbjct: 43 SFVGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARC 102
Query: 658 -VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
V + + + + ++I DIND+ P F ++ + I EN+ G A DPD
Sbjct: 103 LVNFNILMEDKMNLYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDV 162
Query: 717 GPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKYELVIRAA--- 770
G N++ Y + + FSL + G D+ ELV LD E R + LV+ A+
Sbjct: 163 GTNSLQSYQL---SPNRHFSLAVQSGDDETKYPELVLERVLDREEER-VHHLVLTASDGG 218
Query: 771 SPPLWNDVRVEILVTDVNDNAPV--MKDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTD 825
PP + +++ V DVND+ PV + +Q+ + PVG V A D D V
Sbjct: 219 DPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV---TVPENVPVGTRLLTVHAIDLDEGVNG 275
Query: 826 KLQY--RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEI-KAMMQL 882
++ Y R ++ + LN TG ++ L+ MEV DG + KA + +
Sbjct: 276 EVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLI 335
Query: 883 SV 884
+V
Sbjct: 336 TV 337
>AF152305-1|AAD43699.1| 950|Homo sapiens protocadherin alpha 1
protein.
Length = 950
Score = 225 bits (550), Expect = 2e-57
Identities = 170/619 (27%), Positives = 282/619 (45%), Gaps = 35/619 (5%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ ++ ++G L + +DRE++ +++ + + ++DR + V + D NDN
Sbjct: 72 RDLLEVNLQNGILFVNSRIDREELCQWSA--ECSIHLELIADRPLQVFHVEVKVKDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
P F + + + E + I A DAD+GAN+ + Y + + FS+D +
Sbjct: 130 PPVFRGREQIIFIPESRLLNSRFPIEG--AADADIGANALLTYTLSPSD---YFSLDVEA 184
Query: 207 GD-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
D + L K LD E+ L++ A DGG P T +LLI + DVNDNAP F
Sbjct: 185 SDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ 244
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
++++ + E G + + A DADEGVN E+ ++ D + ++ +D SG +
Sbjct: 245 AVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSF-DSGISRDIQEKFKVDSSSGEIR 303
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
+LD E Y++ V A D G PP S + + ED
Sbjct: 304 LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDA 363
Query: 380 PPGTPVVTLTATDADEDNRLHYEITGG---NTRGRFSITSQNGRGLITVAQPLDFKQERR 436
P T + +T +D D+ + ++T + + T +N L+ + LD +
Sbjct: 364 PLSTVIALITVSD--RDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESLSV 420
Query: 437 YVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSAT 494
Y L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 495 DSDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D+D NA ++YSL + A++++ ++ ++G + + LD E + V+A
Sbjct: 481 DADAQENALVSYSLVERRVGERALSNYVS---VHAESGKVYALQPLDHEELELLQFQVSA 537
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI-----MEDALVGTS--VSQVGAT 606
RD GVP L +++ V+D NDN P I + LVG V++V A
Sbjct: 538 RDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHVVAKVRAV 597
Query: 607 DADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G N + YEL P F + +G I T + LD ++ + L + D G P
Sbjct: 598 DADSGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEP 657
Query: 666 PQSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 658 ALTATATVLVSLVESGQAP 676
Score = 222 bits (543), Expect = 1e-56
Identities = 171/587 (29%), Positives = 272/587 (46%), Gaps = 54/587 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ PVF ++ + E + A D DIG NA + YT
Sbjct: 118 HVEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYT------ 171
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P D + +S L R LDRE+ +L+ ATD P
Sbjct: 172 --LSPSDYFSLDVEASDELS-------KSLWLELRKYLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L T + + ++D NDN P F + Y V + E + + ++ + A+DAD G N +
Sbjct: 221 -ELQGTVELLITVLDVNDNAPLFDQAVYRVHLLE--TTANGTLVTTLNASDADEGVNGEV 277
Query: 188 RYAIIGG---NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
++ G + Q +F +DS SG++ L+ LDYE+ +SY + ++A D GSP SN ++L
Sbjct: 278 VFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP + + E+ P+ I + D D G N ++T ++ +
Sbjct: 338 VKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGR-----FSITS 416
F +Y V + E+ PPG + T++A DAD ++N L Y + R S+ +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHA 512
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
++G+ + QPLD ++ VSA D+G +Q+ + D N+ AP AP
Sbjct: 513 ESGK--VYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL-LAPR 569
Query: 475 T----ASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
+V E P G V V A D+D G NA ++Y L + F +
Sbjct: 570 VGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARI-----PFRV 624
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T ++LD +S Y L V +D G P+L+ T V +S+V+
Sbjct: 625 GLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 219 bits (534), Expect = 2e-55
Identities = 164/542 (30%), Positives = 251/542 (46%), Gaps = 32/542 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + E+ + A DAD G NA LTYT++ DY +
Sbjct: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF-S 179
Query: 305 VDLPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + + +S W+ LDRE + LL+TATDGG P T
Sbjct: 180 LDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRG---RFSITSQN 418
F Y V L E GT V TL A+DADE + + + G +R +F + S +
Sbjct: 240 PLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G I + LD+++ + Y + V A D G S+ V + + D N+ AP
Sbjct: 300 GE--IRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ EDAP+ T + +++ +D D G N Q+T SL + + V+ + ++ +
Sbjct: 358 PIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R ++V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL---TFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
+ ++RA D D G NA + Y ++ + + R G E+ T LD E+ +Y L
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPA--AGGARIPFRVGLYTGEISTTRVLD-EADLSRYRL 647
Query: 766 VI 767
++
Sbjct: 648 LV 649
Score = 182 bits (443), Expect = 2e-44
Identities = 141/450 (31%), Positives = 218/450 (48%), Gaps = 25/450 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V++ + D N+ PVF + E + + + A D+D+G NA +TY+LS S+
Sbjct: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ V D+ ++ + K LDRE L +TA DGG P L T ++ I+V+D
Sbjct: 179 SLDVEASDEL----SKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD---PKDREEGSF 630
VNDN P+F Q +Y +++E GT V+ + A+DAD G+NG + + D +D +E F
Sbjct: 235 VNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQE-KF 293
Query: 631 VIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESD 690
+D +SG IR LD E +++++ A+D G+PP S+ V +K+ D+ND+ P
Sbjct: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVT 353
Query: 691 CLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVT 750
L I E++P+ T I I D D G N V S+ F L + LV
Sbjct: 354 SLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLM---PHVPFKL-VSTFKNYYSLVL 409
Query: 751 MVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDC 807
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 410 DSALDRES-LSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENN 468
Query: 808 FPVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVP 860
P V A DAD + + Y ++ G A N + ++ +G + L+
Sbjct: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEEL 528
Query: 861 KLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+L +VS D GV + + + L V ++ E
Sbjct: 529 ELLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 176 bits (428), Expect = 1e-42
Identities = 113/371 (30%), Positives = 188/371 (50%), Gaps = 10/371 (2%)
Query: 429 LDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGT 486
LD ++ L ++ATD G V++ IT D N+ AP+F+ A Y + E GT
Sbjct: 200 LDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGT 259
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
V ++A+D+D G+N ++ +S S IS + ++F ++ +G I LD E
Sbjct: 260 LVTTLNASDADEGVNGEVVFSFDSGISRDI----QEKFKVDSSSGEIRLIDKLDYEETKS 315
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
Y + V A D G P +S+ V + V+DVNDN P I EDA + T ++ + +
Sbjct: 316 YEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVS 375
Query: 607 DADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
D D G NG++ L P + ++ + ALDRES++ ++L A DGG+P
Sbjct: 376 DRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESLSVYELVVTARDGGSPS 434
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYS- 725
+T V +++ D+ND+ P F T ++ EN+P G I + A D D NA+V YS
Sbjct: 435 LWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Query: 726 IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWNDVRVEIL 783
++ + S ++ ++ + LD+E ++++ R A PPL ++V +++
Sbjct: 495 VERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 784 VTDVNDNAPVM 794
V D NDNAP +
Sbjct: 555 VLDENDNAPAL 565
Score = 128 bits (310), Expect = 2e-28
Identities = 101/324 (31%), Positives = 146/324 (45%), Gaps = 17/324 (5%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
S+ E+A GT V V+ D+G+ L + A H +N Q G + N
Sbjct: 34 SIPEEAKHGTFVGRVA---QDLGLELA---ELVPRLFRVASKTHRDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + + + + VE+ V D+NDN PVF+ + I E L
Sbjct: 88 SRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDNPPVFRGREQIIFIPESRL 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD----REEGSFVIDPASGVIRTNKALDRESVA 651
+ + GA DAD+G N + Y L P D E S + S + K LDRE
Sbjct: 148 LNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELS-KSLWLELRKYLDREETP 206
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
L A DGG P TV + I + D+ND+ P+F+ ++ E + GT + + A
Sbjct: 207 ELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNA 266
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA-- 769
D DEG N V +S G S + + S E+ + LDYE K YE+ ++A
Sbjct: 267 SDADEGVNGEVVFSFDSG-ISRDIQEKFKVDSSSGEIRLIDKLDYEE-TKSYEIQVKAVD 324
Query: 770 -ASPPLWNDVRVEILVTDVNDNAP 792
SPP+ N +V + V DVNDNAP
Sbjct: 325 KGSPPMSNHCKVLVKVLDVNDNAP 348
>AC005609-13|AAC34325.1| 807|Homo sapiens KIAA0345-like 13 protein.
Length = 807
Score = 225 bits (550), Expect = 2e-57
Identities = 170/619 (27%), Positives = 282/619 (45%), Gaps = 35/619 (5%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
+D+ ++ ++G L + +DRE++ +++ + + ++DR + V + D NDN
Sbjct: 72 RDLLEVNLQNGILFVNSRIDREELCQWSA--ECSIHLELIADRPLQVFHVEVKVKDINDN 129
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
P F + + + E + I A DAD+GAN+ + Y + + FS+D +
Sbjct: 130 PPVFRGREQIIFIPESRLLNSRFPIEG--AADADIGANALLTYTLSPSD---YFSLDVEA 184
Query: 207 GD-------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
D + L K LD E+ L++ A DGG P T +LLI + DVNDNAP F
Sbjct: 185 SDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQ 244
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
++++ + E G + + A DADEGVN E+ ++ D + ++ +D SG +
Sbjct: 245 AVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSF-DSGISRDIQEKFKVDSSSGEIR 303
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
+LD E Y++ V A D G PP S + + ED
Sbjct: 304 LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDA 363
Query: 380 PPGTPVVTLTATDADEDNRLHYEITGG---NTRGRFSITSQNGRGLITVAQPLDFKQERR 436
P T + +T +D D+ + ++T + + T +N L+ + LD +
Sbjct: 364 PLSTVIALITVSD--RDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESLSV 420
Query: 437 YVLTVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSAT 494
Y L V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
Query: 495 DSDVGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTA 553
D+D NA ++YSL + A++++ ++ ++G + + LD E + V+A
Sbjct: 481 DADAQENALVSYSLVERRVGERALSNYVS---VHAESGKVYALQPLDHEELELLQFQVSA 537
Query: 554 RDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANI-----MEDALVGTS--VSQVGAT 606
RD GVP L +++ V+D NDN P I + LVG V++V A
Sbjct: 538 RDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHVVAKVRAV 597
Query: 607 DADVGLNGRIHYELDP-KDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTP 665
DAD G N + YEL P F + +G I T + LD ++ + L + D G P
Sbjct: 598 DADSGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEP 657
Query: 666 PQSSTVIVHIKIEDINDSP 684
++T V + + + +P
Sbjct: 658 ALTATATVLVSLVESGQAP 676
Score = 222 bits (543), Expect = 1e-56
Identities = 171/587 (29%), Positives = 272/587 (46%), Gaps = 54/587 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ V D ND+ PVF ++ + E + A D DIG NA + YT
Sbjct: 118 HVEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYT------ 171
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P D + +S L R LDRE+ +L+ ATD P
Sbjct: 172 --LSPSDYFSLDVEASDELS-------KSLWLELRKYLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L T + + ++D NDN P F + Y V + E + + ++ + A+DAD G N +
Sbjct: 221 -ELQGTVELLITVLDVNDNAPLFDQAVYRVHLLE--TTANGTLVTTLNASDADEGVNGEV 277
Query: 188 RYAIIGG---NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
++ G + Q +F +DS SG++ L+ LDYE+ +SY + ++A D GSP SN ++L
Sbjct: 278 VFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP + + E+ P+ I + D D G N ++T ++ +
Sbjct: 338 VKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRGR-----FSITS 416
F +Y V + E+ PPG + T++A DAD ++N L Y + R S+ +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHA 512
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
++G+ + QPLD ++ VSA D+G +Q+ + D N+ AP AP
Sbjct: 513 ESGK--VYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL-LAPR 569
Query: 475 T----ASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVI 526
+V E P G V V A D+D G NA ++Y L + F +
Sbjct: 570 VGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARI-----PFRV 624
Query: 527 NPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T ++LD +S Y L V +D G P+L+ T V +S+V+
Sbjct: 625 GLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 219 bits (534), Expect = 2e-55
Identities = 164/542 (30%), Positives = 251/542 (46%), Gaps = 32/542 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + E+ + A DAD G NA LTYT++ DY +
Sbjct: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF-S 179
Query: 305 VDLPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ + + +S W+ LDRE + LL+TATDGG P T
Sbjct: 180 LDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRG---RFSITSQN 418
F Y V L E GT V TL A+DADE + + + G +R +F + S +
Sbjct: 240 PLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
G I + LD+++ + Y + V A D G S+ V + + D N+ AP
Sbjct: 300 GE--IRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ EDAP+ T + +++ +D D G N Q+T SL + + V+ + ++ +
Sbjct: 358 PIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R ++V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCL---TFYISENSP----IGTT 705
+ A D G PP S V + + + D ND+ P + + +SE P G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
+ ++RA D D G NA + Y ++ + + R G E+ T LD E+ +Y L
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQPA--AGGARIPFRVGLYTGEISTTRVLD-EADLSRYRL 647
Query: 766 VI 767
++
Sbjct: 648 LV 649
Score = 182 bits (443), Expect = 2e-44
Identities = 141/450 (31%), Positives = 218/450 (48%), Gaps = 25/450 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V++ + D N+ PVF + E + + + A D+D+G NA +TY+LS S+
Sbjct: 119 VEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ V D+ ++ + K LDRE L +TA DGG P L T ++ I+V+D
Sbjct: 179 SLDVEASDEL----SKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELD---PKDREEGSF 630
VNDN P+F Q +Y +++E GT V+ + A+DAD G+NG + + D +D +E F
Sbjct: 235 VNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQE-KF 293
Query: 631 VIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESD 690
+D +SG IR LD E +++++ A+D G+PP S+ V +K+ D+ND+ P
Sbjct: 294 KVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVT 353
Query: 691 CLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVT 750
L I E++P+ T I I D D G N V S+ F L + LV
Sbjct: 354 SLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLM---PHVPFKL-VSTFKNYYSLVL 409
Query: 751 MVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDC 807
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 410 DSALDRES-LSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENN 468
Query: 808 FPVGPFGRVPAYDADVTDK--LQYRILS---GNNA--NLILLNETTGSMTLSPQLNTNVP 860
P V A DAD + + Y ++ G A N + ++ +G + L+
Sbjct: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEEL 528
Query: 861 KLATMEVSVTD-GVNEIKAMMQLSVRLITE 889
+L +VS D GV + + + L V ++ E
Sbjct: 529 ELLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 176 bits (428), Expect = 1e-42
Identities = 113/371 (30%), Positives = 188/371 (50%), Gaps = 10/371 (2%)
Query: 429 LDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFEDAPIGT 486
LD ++ L ++ATD G V++ IT D N+ AP+F+ A Y + E GT
Sbjct: 200 LDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGT 259
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
V ++A+D+D G+N ++ +S S IS + ++F ++ +G I LD E
Sbjct: 260 LVTTLNASDADEGVNGEVVFSFDSGISRDI----QEKFKVDSSSGEIRLIDKLDYEETKS 315
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGAT 606
Y + V A D G P +S+ V + V+DVNDN P I EDA + T ++ + +
Sbjct: 316 YEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVS 375
Query: 607 DADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPP 666
D D G NG++ L P + ++ + ALDRES++ ++L A DGG+P
Sbjct: 376 DRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLV-LDSALDRESLSVYELVVTARDGGSPS 434
Query: 667 QSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYS- 725
+T V +++ D+ND+ P F T ++ EN+P G I + A D D NA+V YS
Sbjct: 435 LWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Query: 726 IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWNDVRVEIL 783
++ + S ++ ++ + LD+E ++++ R A PPL ++V +++
Sbjct: 495 VERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 784 VTDVNDNAPVM 794
V D NDNAP +
Sbjct: 555 VLDENDNAPAL 565
Score = 128 bits (310), Expect = 2e-28
Identities = 101/324 (31%), Positives = 146/324 (45%), Gaps = 17/324 (5%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
S+ E+A GT V V+ D+G+ L + A H +N Q G + N
Sbjct: 34 SIPEEAKHGTFVGRVA---QDLGLELA---ELVPRLFRVASKTHRDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLS-DTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + + + + VE+ V D+NDN PVF+ + I E L
Sbjct: 88 SRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDNPPVFRGREQIIFIPESRL 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKD----REEGSFVIDPASGVIRTNKALDRESVA 651
+ + GA DAD+G N + Y L P D E S + S + K LDRE
Sbjct: 148 LNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELS-KSLWLELRKYLDREETP 206
Query: 652 THDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRA 711
L A DGG P TV + I + D+ND+ P+F+ ++ E + GT + + A
Sbjct: 207 ELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNA 266
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA-- 769
D DEG N V +S G S + + S E+ + LDYE K YE+ ++A
Sbjct: 267 SDADEGVNGEVVFSFDSG-ISRDIQEKFKVDSSSGEIRLIDKLDYEE-TKSYEIQVKAVD 324
Query: 770 -ASPPLWNDVRVEILVTDVNDNAP 792
SPP+ N +V + V DVNDNAP
Sbjct: 325 KGSPPMSNHCKVLVKVLDVNDNAP 348
>BC112098-1|AAI12099.1| 818|Homo sapiens protocadherin beta 1,
precursor protein.
Length = 818
Score = 225 bits (549), Expect = 2e-57
Identities = 175/629 (27%), Positives = 289/629 (45%), Gaps = 40/629 (6%)
Query: 180 DVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQV--RSYRLVIRAQDG-GSPS 236
+VG +A ++ +M F + +GD+ + + LD E + ++ V+ + P
Sbjct: 55 EVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPL 114
Query: 237 RSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM 296
+S + + + D+NDNAP F + E+ P+G A D D G+N YT+
Sbjct: 115 QSFRAE--VRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTL 172
Query: 297 TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXX 356
+ Y + P+ + + LDRE Q + L +TA DGG PP+S TA
Sbjct: 173 SANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVV 232
Query: 357 XXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTR--GRF 412
F Y +++E+ P G+ V T+TA D DE + + Y + F
Sbjct: 233 LDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTF 292
Query: 413 SITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENA 472
I QNG + + PLDF+ Y + + ATD GG S + V + + D N+ P +
Sbjct: 293 QIDPQNGE--VRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVMVS 350
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG- 531
++ + ED+P T V + + D D+ + ++T L D FVI P G
Sbjct: 351 SVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFL----------REDLPFVIKPTFGN 400
Query: 532 --AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
++ T++ LDRE +SGY +T+ A D G PSLS T +E+ + DVNDN P+F++ Y
Sbjct: 401 SYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILT 460
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYE-LDPKDREEGSFV---IDPASGVIRTNKAL 645
+ E+ + +V A D D+G N +I Y L PK+ + F I+ +G + + +
Sbjct: 461 VRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTM 520
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPV----FESDCL--TFYISEN 699
D E++ A DGG SS V V + + D ND+ P+ ++ L + +
Sbjct: 521 DYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRS 580
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
+ G + ++ A D D G N+ + Y + D FS++ + G E+ T+ + P
Sbjct: 581 AEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNG----EIHTLRQISERDP 636
Query: 760 --RKKYELVIRAASPPLWNDVRVEILVTD 786
+K LV P L V + IL+ D
Sbjct: 637 MMQKLIILVQDHGQPALSTTVSLNILLVD 665
Score = 203 bits (496), Expect = 6e-51
Identities = 180/605 (29%), Positives = 262/605 (43%), Gaps = 29/605 (4%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
FR+ ++G L + LDRE + + V S A V + D NDN P
Sbjct: 75 FRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPLQSFRA--EVRVFDINDNAPV 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGG---NTQMQF-SIDSL 205
F K + + E + + A D DVG N Y + + +F S
Sbjct: 133 FLNKEPLLKIPESTPLGSRFPLQ--SAQDLDVGLNGLQNYTLSANGYFHLHTRFCSHGPK 190
Query: 206 SGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L K LD E+ L I A DGGSP +S T + + + DVND+ P+F +++
Sbjct: 191 YAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQ 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
VSEN P G + V A D DEG N +TY++ + IDP++G V G LD
Sbjct: 251 VSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEA--ILKTFQIDPQNGEVRLRGPLD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E Y + + ATDGG SA + M L ED PP T V
Sbjct: 309 FEAIETYDIDIQATDGGG--LSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVV 366
Query: 386 VTLTATDADEDNRLHYEITGGNTRG-RFSI--TSQNGRGLITVAQPLDFKQERRYVLTVS 442
T D D R+ ++T F I T N L+T + LD ++ Y +T+
Sbjct: 367 ALFTI--RDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVT-DRSLDREEVSGYNITIV 423
Query: 443 ATDSGGRSDTA--MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
A D+G S +A M+++ I+D N+ P+F Y +V E+ + V A D D+G
Sbjct: 424 AMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGE 483
Query: 501 NAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
NAQITYSL + + IN G + + +D E + + V A DGG S
Sbjct: 484 NAQITYSLLPPKNGDLSVF--AYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLS 541
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNG 614
LS V + V+D NDN P+ L + + LV G V++V A D D G N
Sbjct: 542 LSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNS 601
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
+ Y L K + G F + +G I T + + L + D G P S+TV ++
Sbjct: 602 WLSYHL-LKATDLGLFSVQRQNGEIHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLN 660
Query: 675 IKIED 679
I + D
Sbjct: 661 ILLVD 665
Score = 172 bits (418), Expect = 2e-41
Identities = 133/443 (30%), Positives = 209/443 (47%), Gaps = 22/443 (4%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE 515
++ + D N+ APVF N + E P+G+ + SA D DVG+N Y+LS+ N
Sbjct: 120 EVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSA---NG 176
Query: 516 AVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVN 575
H + P+ + NK LDRE LT+TA DGG P S T + + V+DVN
Sbjct: 177 YFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVN 236
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE-GSFVIDP 634
D+ P F + +Y A + E++ G+ V+ V A D D G N I Y L +F IDP
Sbjct: 237 DHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDP 296
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G +R LD E++ T+D+ A DGG S V+V ++ D+ND+PP ++
Sbjct: 297 QNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLV--EVVDVNDNPPEVMVSSVSS 354
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
+ E+SP T + D D V ++ + F ++ G+ + LVT L
Sbjct: 355 PLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLR---EDLPFVIKPTFGNSYS-LVTDRSL 410
Query: 755 DYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E Y + I A P L + +E+L++DVNDN P+ ++ I ++ P
Sbjct: 411 DREEV-SGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAV 469
Query: 812 PFGRVPAYDADVTDKLQ--YRILSGNNANL-----ILLNETTGSMTLSPQLNTNVPKLAT 864
G+V A D D+ + Q Y +L N +L I +N G + ++ +
Sbjct: 470 FIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQ 529
Query: 865 MEVSVTDGVNEIKAMMQLSVRLI 887
V TDG + Q++VR++
Sbjct: 530 FVVKATDG-GFLSLSSQVTVRVV 551
Score = 163 bits (397), Expect = 6e-39
Identities = 161/595 (27%), Positives = 250/595 (42%), Gaps = 59/595 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND++PVF ++ + E G+ A D D+G N YT+
Sbjct: 120 EVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLS------ 173
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGA-LLTRASLDREKVARYTVLVKATDQASPVSD 128
+ F G A L+ LDRE+ + + A D SP
Sbjct: 174 ----------ANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPK- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA IHV ++D ND+ PQFS Y V E + + ++A + A D D G N AI
Sbjct: 223 --SGTAHIHVVVLDVNDHVPQFSRLVYRAQVSE--NSPNGSLVATVTAVDLDEGTNKAIT 278
Query: 189 YAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y++ + F ID +G+V L LD+E + +Y + I+A DGG S +++L+
Sbjct: 279 YSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAH--SKVLVE 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDN P S + E+ P + D D V ++T + + D
Sbjct: 337 VVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLRE-------D 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP I P G Y T LDRE + Y + + A D G P SA
Sbjct: 390 LPFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEI---TGGNTRGRFSITSQN 418
F Y + + E+ P + + A D D E+ ++ Y + G+ I+ +
Sbjct: 450 PIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINS 509
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV----FENA 472
G G + + +D++ + + V ATD G S V++ + D N+ P+ +N
Sbjct: 510 GNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNG 569
Query: 473 --PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
P V A G V V A D D G N+ ++Y L A F + Q
Sbjct: 570 TLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLK-------ATDLGLFSVQRQN 622
Query: 531 GAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQ 584
G I T ++ +R+ M L+ + +D G P+LS T + I +VD +EP + Q
Sbjct: 623 GEIHTLRQISERDPMMQKLI-ILVQDHGQPALSTTVSLNILLVD-GFSEPYLQFQ 675
Score = 142 bits (344), Expect = 2e-32
Identities = 132/464 (28%), Positives = 201/464 (43%), Gaps = 41/464 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + VLD NDH P F Y A V E + +G+ V T+ A D D G N + Y++
Sbjct: 227 HIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSL----- 281
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
NPE + F+ID ++G + R LD E + Y + ++ATD
Sbjct: 282 -AQNPE-----------AILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGG--- 326
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS+ + + V ++D NDN P+ + + + ED V+A D D+ +
Sbjct: 327 --LSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPED--SPPQTVVALFTIRDRDIRVGGKV 382
Query: 188 RYAIIGGNTQMQFSIDSLSGD-VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
+ + F I G+ SLV ++LD E+V Y + I A D G PS S T +
Sbjct: 383 TCFL---REDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIE 439
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTG 303
+ I DVNDN P F + +V EN I +V A D D G NA++TY+ + K+
Sbjct: 440 VLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDL 499
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+V I+I+ +G +Y +D E +Q +V ATDGG S+ T
Sbjct: 500 SVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNR 559
Query: 364 XXFM-PGQYEVELAEDEPP-----GTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSIT 415
+ P Q D P G V + A D D +++ L Y + G FS+
Sbjct: 560 PMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQ 619
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINI 459
QNG I + + + L + D G + + V +NI
Sbjct: 620 RQNGE--IHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLNI 661
>BC112096-1|AAI12097.1| 818|Homo sapiens protocadherin beta 1,
precursor protein.
Length = 818
Score = 225 bits (549), Expect = 2e-57
Identities = 175/629 (27%), Positives = 289/629 (45%), Gaps = 40/629 (6%)
Query: 180 DVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQV--RSYRLVIRAQDG-GSPS 236
+VG +A ++ +M F + +GD+ + + LD E + ++ V+ + P
Sbjct: 55 EVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPL 114
Query: 237 RSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM 296
+S + + + D+NDNAP F + E+ P+G A D D G+N YT+
Sbjct: 115 QSFRAE--VRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTL 172
Query: 297 TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXX 356
+ Y + P+ + + LDRE Q + L +TA DGG PP+S TA
Sbjct: 173 SANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVV 232
Query: 357 XXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTR--GRF 412
F Y +++E+ P G+ V T+TA D DE + + Y + F
Sbjct: 233 LDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTF 292
Query: 413 SITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENA 472
I QNG + + PLDF+ Y + + ATD GG S + V + + D N+ P +
Sbjct: 293 QIDPQNGE--VRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVMVS 350
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG- 531
++ + ED+P T V + + D D+ + ++T L D FVI P G
Sbjct: 351 SVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFL----------REDLPFVIKPTFGN 400
Query: 532 --AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
++ T++ LDRE +SGY +T+ A D G PSLS T +E+ + DVNDN P+F++ Y
Sbjct: 401 SYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILT 460
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYE-LDPKDREEGSFV---IDPASGVIRTNKAL 645
+ E+ + +V A D D+G N +I Y L PK+ + F I+ +G + + +
Sbjct: 461 VRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTM 520
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPV----FESDCL--TFYISEN 699
D E++ A DGG SS V V + + D ND+ P+ ++ L + +
Sbjct: 521 DYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRS 580
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
+ G + ++ A D D G N+ + Y + D FS++ + G E+ T+ + P
Sbjct: 581 AEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNG----EIHTLRQISERDP 636
Query: 760 --RKKYELVIRAASPPLWNDVRVEILVTD 786
+K LV P L V + IL+ D
Sbjct: 637 MMQKLIILVQDHGQPALSTTVSLNILLVD 665
Score = 203 bits (496), Expect = 6e-51
Identities = 180/605 (29%), Positives = 262/605 (43%), Gaps = 29/605 (4%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
FR+ ++G L + LDRE + + V S A V + D NDN P
Sbjct: 75 FRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPLQSFRA--EVRVFDINDNAPV 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGG---NTQMQF-SIDSL 205
F K + + E + + A D DVG N Y + + +F S
Sbjct: 133 FLNKEPLLKIPESTPLGSRFPLQ--SAQDLDVGLNGLQNYTLSANGYFHLHTRFCSHGPK 190
Query: 206 SGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L K LD E+ L I A DGGSP +S T + + + DVND+ P+F +++
Sbjct: 191 YAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQ 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
VSEN P G + V A D DEG N +TY++ + IDP++G V G LD
Sbjct: 251 VSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEA--ILKTFQIDPQNGEVRLRGPLD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E Y + + ATDGG SA + M L ED PP T V
Sbjct: 309 FEAIETYDIDIQATDGGG--LSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVV 366
Query: 386 VTLTATDADEDNRLHYEITGGNTRG-RFSI--TSQNGRGLITVAQPLDFKQERRYVLTVS 442
T D D R+ ++T F I T N L+T + LD ++ Y +T+
Sbjct: 367 ALFTI--RDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVT-DRSLDREEVSGYNITIV 423
Query: 443 ATDSGGRSDTA--MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
A D+G S +A M+++ I+D N+ P+F Y +V E+ + V A D D+G
Sbjct: 424 AMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGE 483
Query: 501 NAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
NAQITYSL + + IN G + + +D E + + V A DGG S
Sbjct: 484 NAQITYSLLPPKNGDLSVF--AYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLS 541
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNG 614
LS V + V+D NDN P+ L + + LV G V++V A D D G N
Sbjct: 542 LSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNS 601
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
+ Y L K + G F + +G I T + + L + D G P S+TV ++
Sbjct: 602 WLSYHL-LKATDLGLFSVQRQNGEIHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLN 660
Query: 675 IKIED 679
I + D
Sbjct: 661 ILLVD 665
Score = 172 bits (418), Expect = 2e-41
Identities = 133/443 (30%), Positives = 209/443 (47%), Gaps = 22/443 (4%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE 515
++ + D N+ APVF N + E P+G+ + SA D DVG+N Y+LS+ N
Sbjct: 120 EVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSA---NG 176
Query: 516 AVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVN 575
H + P+ + NK LDRE LT+TA DGG P S T + + V+DVN
Sbjct: 177 YFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVN 236
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE-GSFVIDP 634
D+ P F + +Y A + E++ G+ V+ V A D D G N I Y L +F IDP
Sbjct: 237 DHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDP 296
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G +R LD E++ T+D+ A DGG S V+V ++ D+ND+PP ++
Sbjct: 297 QNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLV--EVVDVNDNPPEVMVSSVSS 354
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
+ E+SP T + D D V ++ + F ++ G+ + LVT L
Sbjct: 355 PLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLR---EDLPFVIKPTFGNSYS-LVTDRSL 410
Query: 755 DYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E Y + I A P L + +E+L++DVNDN P+ ++ I ++ P
Sbjct: 411 DREEV-SGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAV 469
Query: 812 PFGRVPAYDADVTDKLQ--YRILSGNNANL-----ILLNETTGSMTLSPQLNTNVPKLAT 864
G+V A D D+ + Q Y +L N +L I +N G + ++ +
Sbjct: 470 FIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQ 529
Query: 865 MEVSVTDGVNEIKAMMQLSVRLI 887
V TDG + Q++VR++
Sbjct: 530 FVVKATDG-GFLSLSSQVTVRVV 551
Score = 163 bits (397), Expect = 6e-39
Identities = 161/595 (27%), Positives = 250/595 (42%), Gaps = 59/595 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND++PVF ++ + E G+ A D D+G N YT+
Sbjct: 120 EVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLS------ 173
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGA-LLTRASLDREKVARYTVLVKATDQASPVSD 128
+ F G A L+ LDRE+ + + A D SP
Sbjct: 174 ----------ANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPK- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA IHV ++D ND+ PQFS Y V E + + ++A + A D D G N AI
Sbjct: 223 --SGTAHIHVVVLDVNDHVPQFSRLVYRAQVSE--NSPNGSLVATVTAVDLDEGTNKAIT 278
Query: 189 YAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y++ + F ID +G+V L LD+E + +Y + I+A DGG S +++L+
Sbjct: 279 YSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAH--SKVLVE 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDN P S + E+ P + D D V ++T + + D
Sbjct: 337 VVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLRE-------D 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP I P G Y T LDRE + Y + + A D G P SA
Sbjct: 390 LPFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEI---TGGNTRGRFSITSQN 418
F Y + + E+ P + + A D D E+ ++ Y + G+ I+ +
Sbjct: 450 PIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINS 509
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV----FENA 472
G G + + +D++ + + V ATD G S V++ + D N+ P+ +N
Sbjct: 510 GNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNG 569
Query: 473 --PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
P V A G V V A D D G N+ ++Y L A F + Q
Sbjct: 570 TLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLK-------ATDLGLFSVQRQN 622
Query: 531 GAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQ 584
G I T ++ +R+ M L+ + +D G P+LS T + I +VD +EP + Q
Sbjct: 623 GEIHTLRQISERDPMMQKLI-ILVQDHGQPALSTTVSLNILLVD-GFSEPYLQFQ 675
Score = 142 bits (344), Expect = 2e-32
Identities = 132/464 (28%), Positives = 201/464 (43%), Gaps = 41/464 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + VLD NDH P F Y A V E + +G+ V T+ A D D G N + Y++
Sbjct: 227 HIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSL----- 281
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
NPE + F+ID ++G + R LD E + Y + ++ATD
Sbjct: 282 -AQNPE-----------AILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGG--- 326
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS+ + + V ++D NDN P+ + + + ED V+A D D+ +
Sbjct: 327 --LSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPED--SPPQTVVALFTIRDRDIRVGGKV 382
Query: 188 RYAIIGGNTQMQFSIDSLSGD-VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
+ + F I G+ SLV ++LD E+V Y + I A D G PS S T +
Sbjct: 383 TCFL---REDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIE 439
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTG 303
+ I DVNDN P F + +V EN I +V A D D G NA++TY+ + K+
Sbjct: 440 VLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDL 499
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+V I+I+ +G +Y +D E +Q +V ATDGG S+ T
Sbjct: 500 SVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNR 559
Query: 364 XXFM-PGQYEVELAEDEPP-----GTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSIT 415
+ P Q D P G V + A D D +++ L Y + G FS+
Sbjct: 560 PMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQ 619
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINI 459
QNG I + + + L + D G + + V +NI
Sbjct: 620 RQNGE--IHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLNI 661
>AF152488-1|AAD43749.1| 818|Homo sapiens protocadherin beta 1
protein.
Length = 818
Score = 225 bits (549), Expect = 2e-57
Identities = 175/629 (27%), Positives = 289/629 (45%), Gaps = 40/629 (6%)
Query: 180 DVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQV--RSYRLVIRAQDG-GSPS 236
+VG +A ++ +M F + +GD+ + + LD E + ++ V+ + P
Sbjct: 55 EVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPL 114
Query: 237 RSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTM 296
+S + + + D+NDNAP F + E+ P+G A D D G+N YT+
Sbjct: 115 QSFRAE--VRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTL 172
Query: 297 TDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXX 356
+ Y + P+ + + LDRE Q + L +TA DGG PP+S TA
Sbjct: 173 SANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVV 232
Query: 357 XXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTR--GRF 412
F Y +++E+ P G+ V T+TA D DE + + Y + F
Sbjct: 233 LDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTF 292
Query: 413 SITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENA 472
I QNG + + PLDF+ Y + + ATD GG S + V + + D N+ P +
Sbjct: 293 QIDPQNGE--VRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVMVS 350
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG- 531
++ + ED+P T V + + D D+ + ++T L D FVI P G
Sbjct: 351 SVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFL----------REDLPFVIKPTFGN 400
Query: 532 --AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN 589
++ T++ LDRE +SGY +T+ A D G PSLS T +E+ + DVNDN P+F++ Y
Sbjct: 401 SYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILT 460
Query: 590 IMEDALVGTSVSQVGATDADVGLNGRIHYE-LDPKDREEGSFV---IDPASGVIRTNKAL 645
+ E+ + +V A D D+G N +I Y L PK+ + F I+ +G + + +
Sbjct: 461 VRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTM 520
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPV----FESDCL--TFYISEN 699
D E++ A DGG SS V V + + D ND+ P+ ++ L + +
Sbjct: 521 DYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRS 580
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESP 759
+ G + ++ A D D G N+ + Y + D FS++ + G E+ T+ + P
Sbjct: 581 AEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNG----EIHTLRQISERDP 636
Query: 760 --RKKYELVIRAASPPLWNDVRVEILVTD 786
+K LV P L V + IL+ D
Sbjct: 637 MMQKLIILVQDHGQPALSTTVSLNILLVD 665
Score = 203 bits (496), Expect = 6e-51
Identities = 180/605 (29%), Positives = 262/605 (43%), Gaps = 29/605 (4%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
FR+ ++G L + LDRE + + V S A V + D NDN P
Sbjct: 75 FRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPLQSFRA--EVRVFDINDNAPV 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGG---NTQMQF-SIDSL 205
F K + + E + + A D DVG N Y + + +F S
Sbjct: 133 FLNKEPLLKIPESTPLGSRFPLQ--SAQDLDVGLNGLQNYTLSANGYFHLHTRFCSHGPK 190
Query: 206 SGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L K LD E+ L I A DGGSP +S T + + + DVND+ P+F +++
Sbjct: 191 YAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQ 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
VSEN P G + V A D DEG N +TY++ + IDP++G V G LD
Sbjct: 251 VSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEA--ILKTFQIDPQNGEVRLRGPLD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E Y + + ATDGG SA + M L ED PP T V
Sbjct: 309 FEAIETYDIDIQATDGGG--LSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVV 366
Query: 386 VTLTATDADEDNRLHYEITGGNTRG-RFSI--TSQNGRGLITVAQPLDFKQERRYVLTVS 442
T D D R+ ++T F I T N L+T + LD ++ Y +T+
Sbjct: 367 ALFTI--RDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVT-DRSLDREEVSGYNITIV 423
Query: 443 ATDSGGRSDTA--MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGI 500
A D+G S +A M+++ I+D N+ P+F Y +V E+ + V A D D+G
Sbjct: 424 AMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGE 483
Query: 501 NAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPS 560
NAQITYSL + + IN G + + +D E + + V A DGG S
Sbjct: 484 NAQITYSLLPPKNGDLSVF--AYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLS 541
Query: 561 LSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNG 614
LS V + V+D NDN P+ L + + LV G V++V A D D G N
Sbjct: 542 LSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNS 601
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVH 674
+ Y L K + G F + +G I T + + L + D G P S+TV ++
Sbjct: 602 WLSYHL-LKATDLGLFSVQRQNGEIHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLN 660
Query: 675 IKIED 679
I + D
Sbjct: 661 ILLVD 665
Score = 172 bits (418), Expect = 2e-41
Identities = 133/443 (30%), Positives = 209/443 (47%), Gaps = 22/443 (4%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE 515
++ + D N+ APVF N + E P+G+ + SA D DVG+N Y+LS+ N
Sbjct: 120 EVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSA---NG 176
Query: 516 AVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVN 575
H + P+ + NK LDRE LT+TA DGG P S T + + V+DVN
Sbjct: 177 YFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVN 236
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE-GSFVIDP 634
D+ P F + +Y A + E++ G+ V+ V A D D G N I Y L +F IDP
Sbjct: 237 DHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDP 296
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+G +R LD E++ T+D+ A DGG S V+V ++ D+ND+PP ++
Sbjct: 297 QNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLV--EVVDVNDNPPEVMVSSVSS 354
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
+ E+SP T + D D V ++ + F ++ G+ + LVT L
Sbjct: 355 PLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLR---EDLPFVIKPTFGNSYS-LVTDRSL 410
Query: 755 DYESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E Y + I A P L + +E+L++DVNDN P+ ++ I ++ P
Sbjct: 411 DREEV-SGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAV 469
Query: 812 PFGRVPAYDADVTDKLQ--YRILSGNNANL-----ILLNETTGSMTLSPQLNTNVPKLAT 864
G+V A D D+ + Q Y +L N +L I +N G + ++ +
Sbjct: 470 FIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQ 529
Query: 865 MEVSVTDGVNEIKAMMQLSVRLI 887
V TDG + Q++VR++
Sbjct: 530 FVVKATDG-GFLSLSSQVTVRVV 551
Score = 163 bits (397), Expect = 6e-39
Identities = 161/595 (27%), Positives = 250/595 (42%), Gaps = 59/595 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D ND++PVF ++ + E G+ A D D+G N YT+
Sbjct: 120 EVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLS------ 173
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGA-LLTRASLDREKVARYTVLVKATDQASPVSD 128
+ F G A L+ LDRE+ + + A D SP
Sbjct: 174 ----------ANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPK- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA IHV ++D ND+ PQFS Y V E + + ++A + A D D G N AI
Sbjct: 223 --SGTAHIHVVVLDVNDHVPQFSRLVYRAQVSE--NSPNGSLVATVTAVDLDEGTNKAIT 278
Query: 189 YAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y++ + F ID +G+V L LD+E + +Y + I+A DGG S +++L+
Sbjct: 279 YSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAH--SKVLVE 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDN P S + E+ P + D D V ++T + + D
Sbjct: 337 VVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLRE-------D 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP I P G Y T LDRE + Y + + A D G P SA
Sbjct: 390 LPFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEI---TGGNTRGRFSITSQN 418
F Y + + E+ P + + A D D E+ ++ Y + G+ I+ +
Sbjct: 450 PIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINS 509
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV----FENA 472
G G + + +D++ + + V ATD G S V++ + D N+ P+ +N
Sbjct: 510 GNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNG 569
Query: 473 --PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQT 530
P V A G V V A D D G N+ ++Y L A F + Q
Sbjct: 570 TLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLK-------ATDLGLFSVQRQN 622
Query: 531 GAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQ 584
G I T ++ +R+ M L+ + +D G P+LS T + I +VD +EP + Q
Sbjct: 623 GEIHTLRQISERDPMMQKLI-ILVQDHGQPALSTTVSLNILLVD-GFSEPYLQFQ 675
Score = 142 bits (344), Expect = 2e-32
Identities = 132/464 (28%), Positives = 201/464 (43%), Gaps = 41/464 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + VLD NDH P F Y A V E + +G+ V T+ A D D G N + Y++
Sbjct: 227 HIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSL----- 281
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
NPE + F+ID ++G + R LD E + Y + ++ATD
Sbjct: 282 -AQNPE-----------AILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGG--- 326
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
LS+ + + V ++D NDN P+ + + + ED V+A D D+ +
Sbjct: 327 --LSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPED--SPPQTVVALFTIRDRDIRVGGKV 382
Query: 188 RYAIIGGNTQMQFSIDSLSGD-VSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
+ + F I G+ SLV ++LD E+V Y + I A D G PS S T +
Sbjct: 383 TCFL---REDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIE 439
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTG 303
+ I DVNDN P F + +V EN I +V A D D G NA++TY+ + K+
Sbjct: 440 VLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDL 499
Query: 304 NVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+V I+I+ +G +Y +D E +Q +V ATDGG S+ T
Sbjct: 500 SVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNR 559
Query: 364 XXFM-PGQYEVELAEDEPP-----GTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSIT 415
+ P Q D P G V + A D D +++ L Y + G FS+
Sbjct: 560 PMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQ 619
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINI 459
QNG I + + + L + D G + + V +NI
Sbjct: 620 RQNGE--IHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLNI 661
>AB208958-1|BAD92195.1| 895|Homo sapiens protocadherin gamma
subfamily A, 7 isoform 1 precursor variant protein.
Length = 895
Score = 224 bits (548), Expect = 3e-57
Identities = 187/609 (30%), Positives = 282/609 (46%), Gaps = 34/609 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ + + D+++ I V IID NDN P
Sbjct: 37 LFALNQRSGSLVTAGRIDREEICAQSARCLVNFNIL-MEDKMN-LYPIDVEIIDINDNVP 94
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGD 208
+F + V + E+ + +++ A D DVG NS Y + + FS+ SGD
Sbjct: 95 RFLTEEINVKIMENTAPGVRFPLSE--AGDPDVGTNSLQSYQL---SPNRHFSLAVQSGD 149
Query: 209 -------VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
+ L + LD E+ R + LV A DGG P RS+T + + + DVND+ P F
Sbjct: 150 DGTKYPELVLERVLDREEERVHHLVFTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQ 209
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+Q +V ENVP+G ++ V A D DEGVN E+TY+ + T + ++ +G + T
Sbjct: 210 YQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSF--RKITPKLPKMFHLNSLTGEISTL 267
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E A Y++ V A DG P A + ED P
Sbjct: 268 EGLDYEETAFYEMEVQAQDG--PGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPL 325
Query: 382 GTPVVTLTATDADEDNRLHYEIT-GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + D D T N + + N L+T + LD + Y +T
Sbjct: 326 GTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVT-TKNLDRETLSLYNIT 384
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
+ ATD G S + + + D N+ P F ++ Y+ + E+ P G ++ +V+A D D
Sbjct: 385 LKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDS 444
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NAQITYSL+ + A IN TG + + D E + L VTA D G
Sbjct: 445 EDNAQITYSLAEDTIQGAPV--SSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGD 502
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYT--ANIME----DALVGTSVSQVGATDADVG 611
P LS + + V+D NDN P + L T + ME A G V++V A D D G
Sbjct: 503 PPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSG 562
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSST 670
N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+T
Sbjct: 563 QNAWLSYLL-LKASEPGLFAVGLYTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSAT 620
Query: 671 VIVHIKIED 679
V + + + D
Sbjct: 621 VTLTVAVAD 629
Score = 193 bits (471), Expect = 7e-48
Identities = 137/439 (31%), Positives = 215/439 (48%), Gaps = 23/439 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRG-- 421
F+ + V++ E+ PG A D D N L Y+++ FS+ Q+G
Sbjct: 96 FLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNR---HFSLAVQSGDDGT 152
Query: 422 ---LITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
+ + + LD ++ER + L +A+D G RS TA +Q+ + D N++ PVF Y
Sbjct: 153 KYPELVLERVLDREEERVHHLVFTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 212
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+V E+ P+GT +L V A D D G+N ++TYS + + F +N TG I+T
Sbjct: 213 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSF-----RKITPKLPKMFHLNSLTGEISTL 267
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LD E + Y + V A+DG P V I+V+DVNDN P +++I ED +
Sbjct: 268 EGLDYEETAFYEMEVQAQDG--PGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPL 325
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
GT ++ D D G NG + + + ID ++ T K LDRE+++ +++
Sbjct: 326 GTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLV-TTKNLDRETLSLYNIT 384
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
A DGGTPP S + +++ D ND+PP F + YI+EN+P G +I + A D D
Sbjct: 385 LKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDS 444
Query: 717 GPNAVVHYSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPRKKYELVIR--AASPP 773
NA + YS+ + S SD L + DYE R+ V + PP
Sbjct: 445 EDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPP 504
Query: 774 LWNDVRVEILVTDVNDNAP 792
L +++ + + V D NDN P
Sbjct: 505 LSSNMSLSLFVLDQNDNPP 523
Score = 169 bits (412), Expect = 9e-41
Identities = 138/472 (29%), Positives = 216/472 (45%), Gaps = 38/472 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H Q+ V+D NDH+PVF + QY+ +V E GT +LT+ A D D G N EV Y+ +T
Sbjct: 190 HIQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKIT- 248
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
P+ + +F ++ +G + T LD E+ A Y + V+A D P S
Sbjct: 249 ----PK------------LPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQD--GPGS 290
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
+ A + + ++D NDN P+ + + + S+ ED + VIA D D G N +
Sbjct: 291 ---LTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPL--GTVIALFYLQDRDSGKNGEV 345
Query: 188 RYAIIGG-NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I +++ SID+ V+ K LD E + Y + ++A DGG+P S T + +
Sbjct: 346 TCTIPENLPFKLEKSIDNYYRLVT-TKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQ 404
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NV 305
+ D NDN P F S + ++EN P G SI V A D D NA++TY++ + G V
Sbjct: 405 VADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPV 464
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
++I+ +G +Y D E + QL VTA D GDPP S+ +
Sbjct: 465 SSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPE 524
Query: 366 FM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G +ELA PG V + A D D L Y + + G F++
Sbjct: 525 ILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGL 584
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A++ V
Sbjct: 585 YTGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEV 634
Score = 72.1 bits (169), Expect = 3e-11
Identities = 83/302 (27%), Positives = 130/302 (43%), Gaps = 25/302 (8%)
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGS---FVIDPASGVIRTNKALDRESVATHDLKA 657
S VG D+GL R E + G F ++ SG + T +DRE + +
Sbjct: 6 SFVGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARC 65
Query: 658 -VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
V + + + + ++I DIND+ P F ++ + I EN+ G A DPD
Sbjct: 66 LVNFNILMEDKMNLYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDV 125
Query: 717 GPNAVVHYSIKGGDDSNSFSLETRQGSDKA---ELVTMVDLDYESPRKKYELVIRAA--- 770
G N++ Y + + FSL + G D ELV LD E R + LV A+
Sbjct: 126 GTNSLQSYQL---SPNRHFSLAVQSGDDGTKYPELVLERVLDREEER-VHHLVFTASDGG 181
Query: 771 SPPLWNDVRVEILVTDVNDNAPV--MKDFQIIFNNYKDCFPVGP-FGRVPAYDAD--VTD 825
PP + +++ V DVND+ PV + +Q+ + PVG V A D D V
Sbjct: 182 DPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV---TVPENVPVGTRLLTVHAIDLDEGVNG 238
Query: 826 KLQY--RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEI-KAMMQL 882
++ Y R ++ + LN TG ++ L+ MEV DG + KA + +
Sbjct: 239 EVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLI 298
Query: 883 SV 884
+V
Sbjct: 299 TV 300
>BC031837-1|AAH31837.1| 800|Homo sapiens protocadherin beta 10
protein.
Length = 800
Score = 224 bits (547), Expect = 4e-57
Identities = 185/604 (30%), Positives = 268/604 (44%), Gaps = 32/604 (5%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 77 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVRDINDHAPVFQ 134
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSL 211
+K + + E+ + + +A D D G N Y I + F I+ GD +
Sbjct: 135 DKETVLKISENTA--EGTAFRLERAQDPDGGLNGIQNYTI---SPNSFFHINISGGDEGM 189
Query: 212 V-------KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
+ K LD E+ L + A DGGSPSRS T+ + I + DVNDNAP+F +L++
Sbjct: 190 IYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYET 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
EN PIG+ IV+V A D D GVNAE++Y+ D + N+ I+P SG ++ L
Sbjct: 250 QAPENSPIGFLIVKVWAEDVDSGVNAEVSYSFFDA--SENIRTTFQINPFSGEIFLRELL 307
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ + A DGG SA + + +AE+ P TP
Sbjct: 308 DYELVNSYKINIQAMDGGG--LSARCRVLVEVLDTNDNPPELIVSSFSNSVAENSPE-TP 364
Query: 385 VVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ D D +N N + +N LIT LD + Y +T++
Sbjct: 365 LAVFKINDRDSGENGKMVCYIQENLPFLLKPSVENFYILITEG-ALDREIRAEYNITITV 423
Query: 444 TDSG-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G R T + + ++D N+ AP F YT V E+ + VSATD D G N
Sbjct: 424 TDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTN 483
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
AQ+TYSL + IN G + + LD E + + V A D G P+L
Sbjct: 484 AQVTYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPAL 541
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGR 615
S V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 542 SREALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW 601
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +H+
Sbjct: 602 LSYQL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHL 660
Query: 676 KIED 679
+ D
Sbjct: 661 LLVD 664
Score = 188 bits (459), Expect = 2e-46
Identities = 165/594 (27%), Positives = 259/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDH+PVF+ ++ + E + GT +A D D G N
Sbjct: 110 MDDPFQIYRAELRVRDINDHAPVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQN 169
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + +N L+ +LDRE+ ++ + A
Sbjct: 170 YTISPNSFFHINISGGDEGMIY---------------PELVLDKALDREEQGELSLTLTA 214
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+T+ + ++D NDN PQF++ Y E+ + +I K+ A D
Sbjct: 215 LDGGSP---SRSGTSTVRIVVLDVNDNAPQFAQALYETQAPENSPI--GFLIVKVWAEDV 269
Query: 180 DVGANSAIRYAIIGG--NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ N + F I+ SG++ L + LDYE V SY++ I+A DGG
Sbjct: 270 DSGVNAEVSYSFFDASENIRTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGG--GL 327
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
S ++L+ + D NDN P S F SV+EN P + + D D G N ++ +
Sbjct: 328 SARCRVLVEVLDTNDNPPELIVSSFSNSVAENSP-ETPLAVFKINDRDSGENGKMVCYIQ 386
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ +LP + P Y T G LDRE +A+Y + +T TD G P
Sbjct: 387 E-------NLPFLLKPSVENFYILITEGALDREIRAEYNITITVTDLGTPRLKTEHNITV 439
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 440 LVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 499
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V ATD G S A+V++ + DAN+
Sbjct: 500 LASLVSINADNGH--LFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLVLDANDN 557
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 558 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 610
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHLLLVD 664
Score = 167 bits (407), Expect = 4e-40
Identities = 122/406 (30%), Positives = 195/406 (48%), Gaps = 24/406 (5%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +++ LT++A D G RS T+ V+I + D N+ AP F A Y E
Sbjct: 194 LVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYETQAPE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
++PIG ++ V A D D G+NA+++YS N F INP +G I +LLD
Sbjct: 254 NSPIGFLIVKVWAEDVDSGVNAEVSYSFFDASENIRTT-----FQINPFSGEIFLRELLD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E ++ Y + + A DGG LS V + V+D NDN P ++ ++ E++ T +
Sbjct: 309 YELVNSYKINIQAMDGG--GLSARCRVLVEVLDTNDNPPELIVSSFSNSVAENS-PETPL 365
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ D D G NG++ + +E F++ P+ ++ T ALDRE A +++
Sbjct: 366 AVFKINDRDSGENGKMVCYI----QENLPFLLKPSVENFYILITEGALDREIRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + D+ND+ P F T ++ EN+ IG + A D D G
Sbjct: 422 TVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
NA V YS+ D + + +D L + LDYE+ + +E + A SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFEFRVGATDRGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L + V +LV D NDN+P + + N C + P P Y
Sbjct: 541 LSREALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 107 bits (256), Expect = 7e-22
Identities = 90/279 (32%), Positives = 127/279 (45%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 73 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVRDINDHA 130
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D GLNG +Y + P + + G+
Sbjct: 131 PVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQNYTISPNSFFHIN-ISGGDEGM 189
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T V I + D+ND+ P F
Sbjct: 190 IYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYET 249
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSPIG I ++ A D D G NA V YS D S + + E+ L
Sbjct: 250 QAPENSPIGFLIVKVWAEDVDSGVNAEVSYSF--FDASENIRTTFQINPFSGEIFLRELL 307
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L RV + V D NDN P
Sbjct: 308 DYELV-NSYKINIQAMDGGGLSARCRVLVEVLDTNDNPP 345
Score = 63.7 bits (148), Expect = 9e-09
Identities = 53/176 (30%), Positives = 77/176 (43%), Gaps = 11/176 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 69 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDIND 128
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF+ ISEN+ GT RA DPD G N + +Y+I NSF G
Sbjct: 129 HAPVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQNYTI----SPNSFFHINISG 184
Query: 743 SDKAELVTMVDLDYESPRKKY-EL-----VIRAASPPLWNDVRVEILVTDVNDNAP 792
D+ + + LD R++ EL + SP V I+V DVNDNAP
Sbjct: 185 GDEGMIYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAP 240
>AY358720-1|AAQ89082.1| 800|Homo sapiens PCDHB10 protein.
Length = 800
Score = 224 bits (547), Expect = 4e-57
Identities = 185/604 (30%), Positives = 268/604 (44%), Gaps = 32/604 (5%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 77 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVRDINDHAPVFQ 134
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSL 211
+K + + E+ + + +A D D G N Y I + F I+ GD +
Sbjct: 135 DKETVLKISENTA--EGTAFRLERAQDPDGGLNGIQNYTI---SPNSFFHINISGGDEGM 189
Query: 212 V-------KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
+ K LD E+ L + A DGGSPSRS T+ + I + DVNDNAP+F +L++
Sbjct: 190 IYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYET 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
EN PIG+ IV+V A D D GVNAE++Y+ D + N+ I+P SG ++ L
Sbjct: 250 QAPENSPIGFLIVKVWAEDVDSGVNAEVSYSFFDA--SENIRTTFQINPFSGEIFLRELL 307
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ + A DGG SA + + +AE+ P TP
Sbjct: 308 DYELVNSYKINIQAMDGGG--LSARCRVLVEVLDTNDNPPELIVSSFSNSVAENSPE-TP 364
Query: 385 VVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ D D +N N + +N LIT LD + Y +T++
Sbjct: 365 LAVFKINDRDSGENGKMVCYIQENLPFLLKPSVENFYILITEG-ALDREIRAEYNITITV 423
Query: 444 TDSG-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G R T + + ++D N+ AP F YT V E+ + VSATD D G N
Sbjct: 424 TDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTN 483
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
AQ+TYSL + IN G + + LD E + + V A D G P+L
Sbjct: 484 AQVTYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPAL 541
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGR 615
S V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 542 SREALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW 601
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +H+
Sbjct: 602 LSYQL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHL 660
Query: 676 KIED 679
+ D
Sbjct: 661 LLVD 664
Score = 188 bits (459), Expect = 2e-46
Identities = 165/594 (27%), Positives = 259/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDH+PVF+ ++ + E + GT +A D D G N
Sbjct: 110 MDDPFQIYRAELRVRDINDHAPVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQN 169
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + +N L+ +LDRE+ ++ + A
Sbjct: 170 YTISPNSFFHINISGGDEGMIY---------------PELVLDKALDREEQGELSLTLTA 214
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+T+ + ++D NDN PQF++ Y E+ + +I K+ A D
Sbjct: 215 LDGGSP---SRSGTSTVRIVVLDVNDNAPQFAQALYETQAPENSPI--GFLIVKVWAEDV 269
Query: 180 DVGANSAIRYAIIGG--NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ N + F I+ SG++ L + LDYE V SY++ I+A DGG
Sbjct: 270 DSGVNAEVSYSFFDASENIRTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGG--GL 327
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
S ++L+ + D NDN P S F SV+EN P + + D D G N ++ +
Sbjct: 328 SARCRVLVEVLDTNDNPPELIVSSFSNSVAENSP-ETPLAVFKINDRDSGENGKMVCYIQ 386
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ +LP + P Y T G LDRE +A+Y + +T TD G P
Sbjct: 387 E-------NLPFLLKPSVENFYILITEGALDREIRAEYNITITVTDLGTPRLKTEHNITV 439
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 440 LVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 499
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V ATD G S A+V++ + DAN+
Sbjct: 500 LASLVSINADNGH--LFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLVLDANDN 557
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 558 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 610
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHLLLVD 664
Score = 167 bits (407), Expect = 4e-40
Identities = 122/406 (30%), Positives = 195/406 (48%), Gaps = 24/406 (5%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +++ LT++A D G RS T+ V+I + D N+ AP F A Y E
Sbjct: 194 LVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYETQAPE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
++PIG ++ V A D D G+NA+++YS N F INP +G I +LLD
Sbjct: 254 NSPIGFLIVKVWAEDVDSGVNAEVSYSFFDASENIRTT-----FQINPFSGEIFLRELLD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E ++ Y + + A DGG LS V + V+D NDN P ++ ++ E++ T +
Sbjct: 309 YELVNSYKINIQAMDGG--GLSARCRVLVEVLDTNDNPPELIVSSFSNSVAENS-PETPL 365
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ D D G NG++ + +E F++ P+ ++ T ALDRE A +++
Sbjct: 366 AVFKINDRDSGENGKMVCYI----QENLPFLLKPSVENFYILITEGALDREIRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + D+ND+ P F T ++ EN+ IG + A D D G
Sbjct: 422 TVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
NA V YS+ D + + +D L + LDYE+ + +E + A SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFEFRVGATDRGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L + V +LV D NDN+P + + N C + P P Y
Sbjct: 541 LSREALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 107 bits (256), Expect = 7e-22
Identities = 90/279 (32%), Positives = 127/279 (45%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 73 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVRDINDHA 130
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D GLNG +Y + P + + G+
Sbjct: 131 PVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQNYTISPNSFFHIN-ISGGDEGM 189
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T V I + D+ND+ P F
Sbjct: 190 IYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYET 249
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSPIG I ++ A D D G NA V YS D S + + E+ L
Sbjct: 250 QAPENSPIGFLIVKVWAEDVDSGVNAEVSYSF--FDASENIRTTFQINPFSGEIFLRELL 307
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L RV + V D NDN P
Sbjct: 308 DYELV-NSYKINIQAMDGGGLSARCRVLVEVLDTNDNPP 345
Score = 63.7 bits (148), Expect = 9e-09
Identities = 53/176 (30%), Positives = 77/176 (43%), Gaps = 11/176 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 69 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDIND 128
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF+ ISEN+ GT RA DPD G N + +Y+I NSF G
Sbjct: 129 HAPVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQNYTI----SPNSFFHINISG 184
Query: 743 SDKAELVTMVDLDYESPRKKY-EL-----VIRAASPPLWNDVRVEILVTDVNDNAP 792
D+ + + LD R++ EL + SP V I+V DVNDNAP
Sbjct: 185 GDEGMIYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAP 240
>AF152489-1|AAD43750.1| 800|Homo sapiens protocadherin beta 10
protein.
Length = 800
Score = 224 bits (547), Expect = 4e-57
Identities = 185/604 (30%), Positives = 268/604 (44%), Gaps = 32/604 (5%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 77 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVRDINDHAPVFQ 134
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSL 211
+K + + E+ + + +A D D G N Y I + F I+ GD +
Sbjct: 135 DKETVLKISENTA--EGTAFRLERAQDPDGGLNGIQNYTI---SPNSFFHINISGGDEGM 189
Query: 212 V-------KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
+ K LD E+ L + A DGGSPSRS T+ + I + DVNDNAP+F +L++
Sbjct: 190 IYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYET 249
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
EN PIG+ IV+V A D D GVNAE++Y+ D + N+ I+P SG ++ L
Sbjct: 250 QAPENSPIGFLIVKVWAEDVDSGVNAEVSYSFFDA--SENIRTTFQINPFSGEIFLRELL 307
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ + A DGG SA + + +AE+ P TP
Sbjct: 308 DYELVNSYKINIQAMDGGG--LSARCRVLVEVLDTNDNPPELIVSSFSNSVAENSPE-TP 364
Query: 385 VVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ D D +N N + +N LIT LD + Y +T++
Sbjct: 365 LAVFKINDRDSGENGKMVCYIQENLPFLLKPSVENFYILITEG-ALDREIRAEYNITITV 423
Query: 444 TDSG-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G R T + + ++D N+ AP F YT V E+ + VSATD D G N
Sbjct: 424 TDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTN 483
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
AQ+TYSL + IN G + + LD E + + V A D G P+L
Sbjct: 484 AQVTYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPAL 541
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGR 615
S V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 542 SREALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW 601
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +H+
Sbjct: 602 LSYQL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHL 660
Query: 676 KIED 679
+ D
Sbjct: 661 LLVD 664
Score = 188 bits (459), Expect = 2e-46
Identities = 165/594 (27%), Positives = 259/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDH+PVF+ ++ + E + GT +A D D G N
Sbjct: 110 MDDPFQIYRAELRVRDINDHAPVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQN 169
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + +N L+ +LDRE+ ++ + A
Sbjct: 170 YTISPNSFFHINISGGDEGMIY---------------PELVLDKALDREEQGELSLTLTA 214
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+T+ + ++D NDN PQF++ Y E+ + +I K+ A D
Sbjct: 215 LDGGSP---SRSGTSTVRIVVLDVNDNAPQFAQALYETQAPENSPI--GFLIVKVWAEDV 269
Query: 180 DVGANSAIRYAIIGG--NTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ N + F I+ SG++ L + LDYE V SY++ I+A DGG
Sbjct: 270 DSGVNAEVSYSFFDASENIRTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGG--GL 327
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
S ++L+ + D NDN P S F SV+EN P + + D D G N ++ +
Sbjct: 328 SARCRVLVEVLDTNDNPPELIVSSFSNSVAENSP-ETPLAVFKINDRDSGENGKMVCYIQ 386
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
+ +LP + P Y T G LDRE +A+Y + +T TD G P
Sbjct: 387 E-------NLPFLLKPSVENFYILITEGALDREIRAEYNITITVTDLGTPRLKTEHNITV 439
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 440 LVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 499
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V ATD G S A+V++ + DAN+
Sbjct: 500 LASLVSINADNGH--LFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLVLDANDN 557
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 558 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 610
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHLLLVD 664
Score = 167 bits (407), Expect = 4e-40
Identities = 122/406 (30%), Positives = 195/406 (48%), Gaps = 24/406 (5%)
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD +++ LT++A D G RS T+ V+I + D N+ AP F A Y E
Sbjct: 194 LVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYETQAPE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
++PIG ++ V A D D G+NA+++YS N F INP +G I +LLD
Sbjct: 254 NSPIGFLIVKVWAEDVDSGVNAEVSYSFFDASENIRTT-----FQINPFSGEIFLRELLD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E ++ Y + + A DGG LS V + V+D NDN P ++ ++ E++ T +
Sbjct: 309 YELVNSYKINIQAMDGG--GLSARCRVLVEVLDTNDNPPELIVSSFSNSVAENS-PETPL 365
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKA 657
+ D D G NG++ + +E F++ P+ ++ T ALDRE A +++
Sbjct: 366 AVFKINDRDSGENGKMVCYI----QENLPFLLKPSVENFYILITEGALDREIRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + D+ND+ P F T ++ EN+ IG + A D D G
Sbjct: 422 TVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPP 773
NA V YS+ D + + +D L + LDYE+ + +E + A SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFEFRVGATDRGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L + V +LV D NDN+P + + N C + P P Y
Sbjct: 541 LSREALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 107 bits (256), Expect = 7e-22
Identities = 90/279 (32%), Positives = 127/279 (45%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 73 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVRDINDHA 130
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D GLNG +Y + P + + G+
Sbjct: 131 PVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQNYTISPNSFFHIN-ISGGDEGM 189
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T V I + D+ND+ P F
Sbjct: 190 IYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAPQFAQALYET 249
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSPIG I ++ A D D G NA V YS D S + + E+ L
Sbjct: 250 QAPENSPIGFLIVKVWAEDVDSGVNAEVSYSF--FDASENIRTTFQINPFSGEIFLRELL 307
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L RV + V D NDN P
Sbjct: 308 DYELV-NSYKINIQAMDGGGLSARCRVLVEVLDTNDNPP 345
Score = 63.7 bits (148), Expect = 9e-09
Identities = 53/176 (30%), Positives = 77/176 (43%), Gaps = 11/176 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 69 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDIND 128
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF+ ISEN+ GT RA DPD G N + +Y+I NSF G
Sbjct: 129 HAPVFQDKETVLKISENTAEGTAFRLERAQDPDGGLNGIQNYTI----SPNSFFHINISG 184
Query: 743 SDKAELVTMVDLDYESPRKKY-EL-----VIRAASPPLWNDVRVEILVTDVNDNAP 792
D+ + + LD R++ EL + SP V I+V DVNDNAP
Sbjct: 185 GDEGMIYPELVLDKALDREEQGELSLTLTALDGGSPSRSGTSTVRIVVLDVNDNAP 240
>BC101038-1|AAI01039.1| 871|Homo sapiens protocadherin gamma
subfamily C, 4 protein.
Length = 871
Score = 223 bits (546), Expect = 5e-57
Identities = 181/615 (29%), Positives = 290/615 (47%), Gaps = 35/615 (5%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
FR+D SGALL + +DRE + + V++ V I+D ND+ P+
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSA--SCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPR 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSID------ 203
F + + + E + KA DADVG+NS Y + ++ F++D
Sbjct: 133 FPRQQLDLEIGE--AAPPGQRFPLEKAQDADVGSNSISSYRL---SSNEHFALDVKKRSD 187
Query: 204 -SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
SL ++ L K LD E+ YRLV+ A DGG+P RS T +L +++ DVNDNAP F S +
Sbjct: 188 GSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ SV E+ P G ++++ A D D G + +T+ + V ++ P +G + G
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHT-PDRVRNLFSLHPTTGKLTLLG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
LD E++ Y+ V A DGG P + L E PG
Sbjct: 307 PLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPG 366
Query: 383 TPVVTLTATDADEDNRLHYEITGGNTRGRFSITS--QNGRGLITVAQPLDFKQERRYVLT 440
T V ++ D D + + + F++ S +N L+T A PLD + + Y +
Sbjct: 367 TVVALISVQDPDSGSNGDVSLRIPD-HLPFALKSAFRNQFSLVT-AGPLDREAKSSYDIM 424
Query: 441 VSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A+D+G S + +NI+D N+ P F + V E+ G + ++A+D D
Sbjct: 425 VTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDS 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G+NA I+YSL + + A F+ +NPQTGA+ + D E V ARD G
Sbjct: 485 GLNALISYSLLEPRNRDVSA---SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRG 541
Query: 558 VPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDAL-----VGTSVSQVGATDADVG 611
P LS T V + V+D+NDN P V + + ++ AL G +++V A D D G
Sbjct: 542 NPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSG 601
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N + Y+L + + F + +G +RT + + + L V D G+PP S++V
Sbjct: 602 YNAWVSYQL-LEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSV 659
Query: 672 IVHIKIEDINDSPPV 686
+ + +E+ D+ PV
Sbjct: 660 TLLVSLEE--DTHPV 672
Score = 192 bits (467), Expect = 2e-47
Identities = 132/441 (29%), Positives = 214/441 (48%), Gaps = 28/441 (6%)
Query: 370 QYEVELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLIT---V 425
Q ++E+ E PPG A DAD N + N + ++ L+ +
Sbjct: 137 QLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLL 196
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+PLD +++ Y L ++A D G RS TA +++++ D N+ AP F+ + Y SV E AP
Sbjct: 197 EKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAP 256
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G ++ ++A+D D+G + +T+ S + F ++P TG +T LD E+
Sbjct: 257 AGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRV----RNLFSLHPTTGKLTLLGPLDFES 312
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y V ARDGG P++ + + ++DVNDN P + E A GT V+ +
Sbjct: 313 ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALI 372
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPA---SGVIRTNKALDRESVATHDLKAVAI 660
D D G NG + + + F + A + T LDRE+ +++D+ A
Sbjct: 373 SVQDPDSGSNGDVSLRIP----DHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTAS 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
D G PP S+ + + I D+ND+PP F ++ EN+ G + + A DPD G NA
Sbjct: 429 DAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNA 488
Query: 721 VVHYSI---KGGDDSNS--FSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPP 773
++ YS+ + D S S SL + G+ A DYE + ++E+ R +PP
Sbjct: 489 LISYSLLEPRNRDVSASSFISLNPQTGAVHATR----SFDYEQTQTLQFEVQARDRGNPP 544
Query: 774 LWNDVRVEILVTDVNDNAPVM 794
L + V V + V D+NDNAP +
Sbjct: 545 LSSTVTVRLFVLDLNDNAPAV 565
Score = 186 bits (454), Expect = 8e-46
Identities = 158/589 (26%), Positives = 264/589 (44%), Gaps = 54/589 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D NDH+P F QQ + + E A G KA D D+G N+ Y +
Sbjct: 120 EVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFA 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L+ + R DG LL LDREK + Y +++ A D +P
Sbjct: 180 LDVKK----------------RSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA + V+++D NDN P F + +Y +SV E S V+ ++ A+D D+G + +
Sbjct: 223 --SGTAELRVSVLDVNDNAPAFQQSSYRISVLE--SAPAGMVLIQLNASDPDLGPSGNVT 278
Query: 189 YAIIG---GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
+ G + FS+ +G ++L+ LD+E Y +RA+DGGSP+ L +
Sbjct: 279 FYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRV 338
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
++ DVNDNAP + ++ E+ G + + D D G N +++ + D ++
Sbjct: 339 DLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPD-----HL 393
Query: 306 DLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ R+ + + T+G LDRE ++ Y ++VTA+D G+PP S T
Sbjct: 394 PFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTR--GRFSITSQNGR 420
F +EV + E+ PG + +L A+D D + + Y + R S S N +
Sbjct: 454 SFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQ 513
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP-VFENAPYTA 476
G + + D++Q + V A D G S T V++ + D N+ AP V
Sbjct: 514 TGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPG 573
Query: 477 SVFEDA---PIGTTVLV--VSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
S+ A +G L+ V+A D D G NA ++Y L A F ++ G
Sbjct: 574 SLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLE-------APDPSLFAVSRYAG 626
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
+ T + + + L + +D G P LS + + +S+ + D PV
Sbjct: 627 EVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSVTLLVSLEE--DTHPV 672
Score = 140 bits (338), Expect = 9e-32
Identities = 128/495 (25%), Positives = 212/495 (42%), Gaps = 39/495 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+++VLD ND++P F+ Y SV E A +G ++ L A+D D+G + V + T D
Sbjct: 229 RVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPD- 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+++F + +G L LD E Y V+A D SP ++
Sbjct: 288 ---------------RVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQ 332
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S + V+++D NDN P + + ++ E S V+A I D D G+N +
Sbjct: 333 HCS---LRVDLLDVNDNAPYITVTSELGTLPE--SAEPGTVVALISVQDPDSGSNGDVSL 387
Query: 190 AIIGGNTQMQFSIDS-LSGDVSLVKT--LDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F++ S SLV LD E SY +++ A D G+P S + +N
Sbjct: 388 RI---PDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLN 444
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD-KDYTGNV 305
I DVNDN P F+ + V EN G + + A D D G+NA ++Y++ + ++ +
Sbjct: 445 ISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSA 504
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
I+++P++G V+ + D E Q V A D G+PP S+T T
Sbjct: 505 SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPA 564
Query: 366 FM-----PGQY-EVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ PG L G + +TA D D + Y++ F+++
Sbjct: 565 VLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRY 624
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTAS 477
G V P D ++ L + DSG + V + ++ + PV + +++
Sbjct: 625 AGEVRTAVPIPADLPPQK---LVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSA 681
Query: 478 VFEDAPIGTTVLVVS 492
E T L VS
Sbjct: 682 PREGESRLTLYLAVS 696
Score = 125 bits (302), Expect = 2e-27
Identities = 94/303 (31%), Positives = 142/303 (46%), Gaps = 25/303 (8%)
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLT-VTARDGGVPSLSD 563
T SLS+ A + + F ++ +GA+ +DRE + G + + + +
Sbjct: 56 TDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLE 115
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG----RI--- 616
E+ +VDVND+ P F +Q I E A G A DADVG N R+
Sbjct: 116 MYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSN 175
Query: 617 -HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
H+ LD K R +GS V + + K LDRE + + L A+DGG PP+S T + +
Sbjct: 176 EHFALDVKKRSDGSLVPE-----LLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRV 230
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDS--- 732
+ D+ND+ P F+ + E++P G + ++ A DPD GP+ V + G
Sbjct: 231 SVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVR 290
Query: 733 NSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVND 789
N FSL G +L + LD+ES YE +RA SP + + + + DVND
Sbjct: 291 NLFSLHPTTG----KLTLLGPLDFES-ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVND 345
Query: 790 NAP 792
NAP
Sbjct: 346 NAP 348
Score = 79.0 bits (186), Expect = 2e-13
Identities = 66/252 (26%), Positives = 113/252 (44%), Gaps = 24/252 (9%)
Query: 4 PFCIHQQI--NVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
P H+ I N+ D ND+ P F + +E V E G + +L A+D D G NA + Y+
Sbjct: 434 PLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYS 493
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
+ L P + ++ ++GA+ S D E+ V+A D
Sbjct: 494 L-------LEPRNRDVSASSFIS-------LNPQTGAVHATRSFDYEQTQTLQFEVQARD 539
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDI---SVTDNPVIAKIKAT 177
+ +P LSST T+ + ++D NDN P + S+ SV +I K+ A
Sbjct: 540 RGNPP---LSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAV 596
Query: 178 DADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D D G N+ + Y ++ F++ +G+V + + + +LVI +D GSP
Sbjct: 597 DLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPL 655
Query: 238 SNTTQLLINIRD 249
S + LL+++ +
Sbjct: 656 STSVTLLVSLEE 667
Score = 66.9 bits (156), Expect = 1e-09
Identities = 67/256 (26%), Positives = 106/256 (41%), Gaps = 18/256 (7%)
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F +D SG + +DRE++ + ++ T ++I D+ND P F
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFP 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKA-- 746
L I E +P G +A D D G N++ Y + + F+L+ ++ SD +
Sbjct: 135 RQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH---FALDVKKRSDGSLV 191
Query: 747 -ELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
EL+ LD E + Y LV+ A +PP + + V DVNDNAP + +
Sbjct: 192 PELLLEKPLDREK-QSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRIS 250
Query: 803 NYKDCFPVG-PFGRVPAYDADVTDKLQYRI-LSGNN----ANLILLNETTGSMTLSPQLN 856
+ P G ++ A D D+ SG+ NL L+ TTG +TL L+
Sbjct: 251 VLESA-PAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLD 309
Query: 857 TNVPKLATMEVSVTDG 872
+V DG
Sbjct: 310 FESENYYEFDVRARDG 325
>BC101036-1|AAI01037.1| 870|Homo sapiens PCDHGC4 protein protein.
Length = 870
Score = 223 bits (546), Expect = 5e-57
Identities = 181/615 (29%), Positives = 290/615 (47%), Gaps = 35/615 (5%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
FR+D SGALL + +DRE + + V++ V I+D ND+ P+
Sbjct: 74 FRVDLDSGALLIKNPIDREALCGLSA--SCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPR 131
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSID------ 203
F + + + E + KA DADVG+NS Y + ++ F++D
Sbjct: 132 FPRQQLDLEIGE--AAPPGQRFPLEKAQDADVGSNSISSYRL---SSNEHFALDVKKRSD 186
Query: 204 -SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
SL ++ L K LD E+ YRLV+ A DGG+P RS T +L +++ DVNDNAP F S +
Sbjct: 187 GSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 246
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ SV E+ P G ++++ A D D G + +T+ + V ++ P +G + G
Sbjct: 247 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHT-PDRVRNLFSLHPTTGKLTLLG 305
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
LD E++ Y+ V A DGG P + L E PG
Sbjct: 306 PLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPG 365
Query: 383 TPVVTLTATDADEDNRLHYEITGGNTRGRFSITS--QNGRGLITVAQPLDFKQERRYVLT 440
T V ++ D D + + + F++ S +N L+T A PLD + + Y +
Sbjct: 366 TVVALISVQDPDSGSNGDVSLRIPD-HLPFALKSAFRNQFSLVT-AGPLDREAKSSYDIM 423
Query: 441 VSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A+D+G S + +NI+D N+ P F + V E+ G + ++A+D D
Sbjct: 424 VTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDS 483
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G+NA I+YSL + + A F+ +NPQTGA+ + D E V ARD G
Sbjct: 484 GLNALISYSLLEPRNRDVSA---SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRG 540
Query: 558 VPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDAL-----VGTSVSQVGATDADVG 611
P LS T V + V+D+NDN P V + + ++ AL G +++V A D D G
Sbjct: 541 NPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSG 600
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N + Y+L + + F + +G +RT + + + L V D G+PP S++V
Sbjct: 601 YNAWVSYQL-LEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSV 658
Query: 672 IVHIKIEDINDSPPV 686
+ + +E+ D+ PV
Sbjct: 659 TLLVSLEE--DTHPV 671
Score = 192 bits (467), Expect = 2e-47
Identities = 132/441 (29%), Positives = 214/441 (48%), Gaps = 28/441 (6%)
Query: 370 QYEVELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLIT---V 425
Q ++E+ E PPG A DAD N + N + ++ L+ +
Sbjct: 136 QLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLL 195
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+PLD +++ Y L ++A D G RS TA +++++ D N+ AP F+ + Y SV E AP
Sbjct: 196 EKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAP 255
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G ++ ++A+D D+G + +T+ S + F ++P TG +T LD E+
Sbjct: 256 AGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRV----RNLFSLHPTTGKLTLLGPLDFES 311
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y V ARDGG P++ + + ++DVNDN P + E A GT V+ +
Sbjct: 312 ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALI 371
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPA---SGVIRTNKALDRESVATHDLKAVAI 660
D D G NG + + + F + A + T LDRE+ +++D+ A
Sbjct: 372 SVQDPDSGSNGDVSLRIP----DHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTAS 427
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
D G PP S+ + + I D+ND+PP F ++ EN+ G + + A DPD G NA
Sbjct: 428 DAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNA 487
Query: 721 VVHYSI---KGGDDSNS--FSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPP 773
++ YS+ + D S S SL + G+ A DYE + ++E+ R +PP
Sbjct: 488 LISYSLLEPRNRDVSASSFISLNPQTGAVHATR----SFDYEQTQTLQFEVQARDRGNPP 543
Query: 774 LWNDVRVEILVTDVNDNAPVM 794
L + V V + V D+NDNAP +
Sbjct: 544 LSSTVTVRLFVLDLNDNAPAV 564
Score = 186 bits (454), Expect = 8e-46
Identities = 158/589 (26%), Positives = 264/589 (44%), Gaps = 54/589 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D NDH+P F QQ + + E A G KA D D+G N+ Y +
Sbjct: 119 EVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFA 178
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L+ + R DG LL LDREK + Y +++ A D +P
Sbjct: 179 LDVKK----------------RSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPR- 221
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA + V+++D NDN P F + +Y +SV E S V+ ++ A+D D+G + +
Sbjct: 222 --SGTAELRVSVLDVNDNAPAFQQSSYRISVLE--SAPAGMVLIQLNASDPDLGPSGNVT 277
Query: 189 YAIIG---GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
+ G + FS+ +G ++L+ LD+E Y +RA+DGGSP+ L +
Sbjct: 278 FYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRV 337
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
++ DVNDNAP + ++ E+ G + + D D G N +++ + D ++
Sbjct: 338 DLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPD-----HL 392
Query: 306 DLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ R+ + + T+G LDRE ++ Y ++VTA+D G+PP S T
Sbjct: 393 PFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPP 452
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTR--GRFSITSQNGR 420
F +EV + E+ PG + +L A+D D + + Y + R S S N +
Sbjct: 453 SFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQ 512
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP-VFENAPYTA 476
G + + D++Q + V A D G S T V++ + D N+ AP V
Sbjct: 513 TGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPG 572
Query: 477 SVFEDA---PIGTTVLV--VSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
S+ A +G L+ V+A D D G NA ++Y L A F ++ G
Sbjct: 573 SLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLE-------APDPSLFAVSRYAG 625
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
+ T + + + L + +D G P LS + + +S+ + D PV
Sbjct: 626 EVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSVTLLVSLEE--DTHPV 671
Score = 140 bits (338), Expect = 9e-32
Identities = 128/495 (25%), Positives = 212/495 (42%), Gaps = 39/495 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+++VLD ND++P F+ Y SV E A +G ++ L A+D D+G + V + T D
Sbjct: 228 RVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPD- 286
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+++F + +G L LD E Y V+A D SP ++
Sbjct: 287 ---------------RVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQ 331
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S + V+++D NDN P + + ++ E S V+A I D D G+N +
Sbjct: 332 HCS---LRVDLLDVNDNAPYITVTSELGTLPE--SAEPGTVVALISVQDPDSGSNGDVSL 386
Query: 190 AIIGGNTQMQFSIDS-LSGDVSLVKT--LDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F++ S SLV LD E SY +++ A D G+P S + +N
Sbjct: 387 RI---PDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLN 443
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD-KDYTGNV 305
I DVNDN P F+ + V EN G + + A D D G+NA ++Y++ + ++ +
Sbjct: 444 ISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSA 503
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
I+++P++G V+ + D E Q V A D G+PP S+T T
Sbjct: 504 SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPA 563
Query: 366 FM-----PGQY-EVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ PG L G + +TA D D + Y++ F+++
Sbjct: 564 VLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRY 623
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTAS 477
G V P D ++ L + DSG + V + ++ + PV + +++
Sbjct: 624 AGEVRTAVPIPADLPPQK---LVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSA 680
Query: 478 VFEDAPIGTTVLVVS 492
E T L VS
Sbjct: 681 PREGESRLTLYLAVS 695
Score = 125 bits (302), Expect = 2e-27
Identities = 94/303 (31%), Positives = 142/303 (46%), Gaps = 25/303 (8%)
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLT-VTARDGGVPSLSD 563
T SLS+ A + + F ++ +GA+ +DRE + G + + + +
Sbjct: 55 TDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLE 114
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG----RI--- 616
E+ +VDVND+ P F +Q I E A G A DADVG N R+
Sbjct: 115 MYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSN 174
Query: 617 -HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
H+ LD K R +GS V + + K LDRE + + L A+DGG PP+S T + +
Sbjct: 175 EHFALDVKKRSDGSLVPE-----LLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRV 229
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDS--- 732
+ D+ND+ P F+ + E++P G + ++ A DPD GP+ V + G
Sbjct: 230 SVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVR 289
Query: 733 NSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVND 789
N FSL G +L + LD+ES YE +RA SP + + + + DVND
Sbjct: 290 NLFSLHPTTG----KLTLLGPLDFES-ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVND 344
Query: 790 NAP 792
NAP
Sbjct: 345 NAP 347
Score = 79.0 bits (186), Expect = 2e-13
Identities = 66/252 (26%), Positives = 113/252 (44%), Gaps = 24/252 (9%)
Query: 4 PFCIHQQI--NVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
P H+ I N+ D ND+ P F + +E V E G + +L A+D D G NA + Y+
Sbjct: 433 PLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYS 492
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
+ L P + ++ ++GA+ S D E+ V+A D
Sbjct: 493 L-------LEPRNRDVSASSFIS-------LNPQTGAVHATRSFDYEQTQTLQFEVQARD 538
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDI---SVTDNPVIAKIKAT 177
+ +P LSST T+ + ++D NDN P + S+ SV +I K+ A
Sbjct: 539 RGNPP---LSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAV 595
Query: 178 DADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D D G N+ + Y ++ F++ +G+V + + + +LVI +D GSP
Sbjct: 596 DLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPL 654
Query: 238 SNTTQLLINIRD 249
S + LL+++ +
Sbjct: 655 STSVTLLVSLEE 666
Score = 66.9 bits (156), Expect = 1e-09
Identities = 67/256 (26%), Positives = 106/256 (41%), Gaps = 18/256 (7%)
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F +D SG + +DRE++ + ++ T ++I D+ND P F
Sbjct: 74 FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFP 133
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKA-- 746
L I E +P G +A D D G N++ Y + + F+L+ ++ SD +
Sbjct: 134 RQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH---FALDVKKRSDGSLV 190
Query: 747 -ELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
EL+ LD E + Y LV+ A +PP + + V DVNDNAP + +
Sbjct: 191 PELLLEKPLDREK-QSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRIS 249
Query: 803 NYKDCFPVG-PFGRVPAYDADVTDKLQYRI-LSGNN----ANLILLNETTGSMTLSPQLN 856
+ P G ++ A D D+ SG+ NL L+ TTG +TL L+
Sbjct: 250 VLESA-PAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLD 308
Query: 857 TNVPKLATMEVSVTDG 872
+V DG
Sbjct: 309 FESENYYEFDVRARDG 324
>BC101035-1|AAI01036.1| 871|Homo sapiens protocadherin gamma
subfamily C, 4 protein.
Length = 871
Score = 223 bits (546), Expect = 5e-57
Identities = 181/615 (29%), Positives = 290/615 (47%), Gaps = 35/615 (5%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
FR+D SGALL + +DRE + + V++ V I+D ND+ P+
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSA--SCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPR 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSID------ 203
F + + + E + KA DADVG+NS Y + ++ F++D
Sbjct: 133 FPRQQLDLEIGE--AAPPGQRFPLEKAQDADVGSNSISSYRL---SSNEHFALDVKKRSD 187
Query: 204 -SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
SL ++ L K LD E+ YRLV+ A DGG+P RS T +L +++ DVNDNAP F S +
Sbjct: 188 GSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ SV E+ P G ++++ A D D G + +T+ + V ++ P +G + G
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHT-PDRVRNLFSLHPTTGKLTLLG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
LD E++ Y+ V A DGG P + L E PG
Sbjct: 307 PLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPG 366
Query: 383 TPVVTLTATDADEDNRLHYEITGGNTRGRFSITS--QNGRGLITVAQPLDFKQERRYVLT 440
T V ++ D D + + + F++ S +N L+T A PLD + + Y +
Sbjct: 367 TVVALISVQDPDSGSNGDVSLRIPD-HLPFALKSAFRNQFSLVT-AGPLDREAKSSYDIM 424
Query: 441 VSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A+D+G S + +NI+D N+ P F + V E+ G + ++A+D D
Sbjct: 425 VTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDS 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G+NA I+YSL + + A F+ +NPQTGA+ + D E V ARD G
Sbjct: 485 GLNALISYSLLEPRNRDVSA---SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRG 541
Query: 558 VPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDAL-----VGTSVSQVGATDADVG 611
P LS T V + V+D+NDN P V + + ++ AL G +++V A D D G
Sbjct: 542 NPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSG 601
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N + Y+L + + F + +G +RT + + + L V D G+PP S++V
Sbjct: 602 YNAWVSYQL-LEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSV 659
Query: 672 IVHIKIEDINDSPPV 686
+ + +E+ D+ PV
Sbjct: 660 TLLVSLEE--DTHPV 672
Score = 192 bits (467), Expect = 2e-47
Identities = 132/441 (29%), Positives = 214/441 (48%), Gaps = 28/441 (6%)
Query: 370 QYEVELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLIT---V 425
Q ++E+ E PPG A DAD N + N + ++ L+ +
Sbjct: 137 QLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLL 196
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+PLD +++ Y L ++A D G RS TA +++++ D N+ AP F+ + Y SV E AP
Sbjct: 197 EKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAP 256
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G ++ ++A+D D+G + +T+ S + F ++P TG +T LD E+
Sbjct: 257 AGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRV----RNLFSLHPTTGKLTLLGPLDFES 312
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y V ARDGG P++ + + ++DVNDN P + E A GT V+ +
Sbjct: 313 ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALI 372
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPA---SGVIRTNKALDRESVATHDLKAVAI 660
D D G NG + + + F + A + T LDRE+ +++D+ A
Sbjct: 373 SVQDPDSGSNGDVSLRIP----DHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTAS 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
D G PP S+ + + I D+ND+PP F ++ EN+ G + + A DPD G NA
Sbjct: 429 DAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNA 488
Query: 721 VVHYSI---KGGDDSNS--FSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPP 773
++ YS+ + D S S SL + G+ A DYE + ++E+ R +PP
Sbjct: 489 LISYSLLEPRNRDVSASSFISLNPQTGAVHATR----SFDYEQTQTLQFEVQARDRGNPP 544
Query: 774 LWNDVRVEILVTDVNDNAPVM 794
L + V V + V D+NDNAP +
Sbjct: 545 LSSTVTVRLFVLDLNDNAPAV 565
Score = 186 bits (454), Expect = 8e-46
Identities = 158/589 (26%), Positives = 264/589 (44%), Gaps = 54/589 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D NDH+P F QQ + + E A G KA D D+G N+ Y +
Sbjct: 120 EVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFA 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L+ + R DG LL LDREK + Y +++ A D +P
Sbjct: 180 LDVKK----------------RSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA + V+++D NDN P F + +Y +SV E S V+ ++ A+D D+G + +
Sbjct: 223 --SGTAELRVSVLDVNDNAPAFQQSSYRISVLE--SAPAGMVLIQLNASDPDLGPSGNVT 278
Query: 189 YAIIG---GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
+ G + FS+ +G ++L+ LD+E Y +RA+DGGSP+ L +
Sbjct: 279 FYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRV 338
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
++ DVNDNAP + ++ E+ G + + D D G N +++ + D ++
Sbjct: 339 DLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPD-----HL 393
Query: 306 DLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ R+ + + T+G LDRE ++ Y ++VTA+D G+PP S T
Sbjct: 394 PFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTR--GRFSITSQNGR 420
F +EV + E+ PG + +L A+D D + + Y + R S S N +
Sbjct: 454 SFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQ 513
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP-VFENAPYTA 476
G + + D++Q + V A D G S T V++ + D N+ AP V
Sbjct: 514 TGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPG 573
Query: 477 SVFEDA---PIGTTVLV--VSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
S+ A +G L+ V+A D D G NA ++Y L A F ++ G
Sbjct: 574 SLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLE-------APDPSLFAVSRYAG 626
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
+ T + + + L + +D G P LS + + +S+ + D PV
Sbjct: 627 EVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSVTLLVSLEE--DTHPV 672
Score = 140 bits (338), Expect = 9e-32
Identities = 128/495 (25%), Positives = 212/495 (42%), Gaps = 39/495 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+++VLD ND++P F+ Y SV E A +G ++ L A+D D+G + V + T D
Sbjct: 229 RVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPD- 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+++F + +G L LD E Y V+A D SP ++
Sbjct: 288 ---------------RVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQ 332
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S + V+++D NDN P + + ++ E S V+A I D D G+N +
Sbjct: 333 HCS---LRVDLLDVNDNAPYITVTSELGTLPE--SAEPGTVVALISVQDPDSGSNGDVSL 387
Query: 190 AIIGGNTQMQFSIDS-LSGDVSLVKT--LDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F++ S SLV LD E SY +++ A D G+P S + +N
Sbjct: 388 RI---PDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLN 444
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD-KDYTGNV 305
I DVNDN P F+ + V EN G + + A D D G+NA ++Y++ + ++ +
Sbjct: 445 ISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSA 504
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
I+++P++G V+ + D E Q V A D G+PP S+T T
Sbjct: 505 SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPA 564
Query: 366 FM-----PGQY-EVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ PG L G + +TA D D + Y++ F+++
Sbjct: 565 VLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRY 624
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTAS 477
G V P D ++ L + DSG + V + ++ + PV + +++
Sbjct: 625 AGEVRTAVPIPADLPPQK---LVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSA 681
Query: 478 VFEDAPIGTTVLVVS 492
E T L VS
Sbjct: 682 PREGESRLTLYLAVS 696
Score = 125 bits (302), Expect = 2e-27
Identities = 94/303 (31%), Positives = 142/303 (46%), Gaps = 25/303 (8%)
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLT-VTARDGGVPSLSD 563
T SLS+ A + + F ++ +GA+ +DRE + G + + + +
Sbjct: 56 TDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLE 115
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG----RI--- 616
E+ +VDVND+ P F +Q I E A G A DADVG N R+
Sbjct: 116 MYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSN 175
Query: 617 -HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
H+ LD K R +GS V + + K LDRE + + L A+DGG PP+S T + +
Sbjct: 176 EHFALDVKKRSDGSLVPE-----LLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRV 230
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDS--- 732
+ D+ND+ P F+ + E++P G + ++ A DPD GP+ V + G
Sbjct: 231 SVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVR 290
Query: 733 NSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVND 789
N FSL G +L + LD+ES YE +RA SP + + + + DVND
Sbjct: 291 NLFSLHPTTG----KLTLLGPLDFES-ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVND 345
Query: 790 NAP 792
NAP
Sbjct: 346 NAP 348
Score = 79.0 bits (186), Expect = 2e-13
Identities = 66/252 (26%), Positives = 113/252 (44%), Gaps = 24/252 (9%)
Query: 4 PFCIHQQI--NVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
P H+ I N+ D ND+ P F + +E V E G + +L A+D D G NA + Y+
Sbjct: 434 PLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYS 493
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
+ L P + ++ ++GA+ S D E+ V+A D
Sbjct: 494 L-------LEPRNRDVSASSFIS-------LNPQTGAVHATRSFDYEQTQTLQFEVQARD 539
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDI---SVTDNPVIAKIKAT 177
+ +P LSST T+ + ++D NDN P + S+ SV +I K+ A
Sbjct: 540 RGNPP---LSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAV 596
Query: 178 DADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D D G N+ + Y ++ F++ +G+V + + + +LVI +D GSP
Sbjct: 597 DLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPL 655
Query: 238 SNTTQLLINIRD 249
S + LL+++ +
Sbjct: 656 STSVTLLVSLEE 667
Score = 66.9 bits (156), Expect = 1e-09
Identities = 67/256 (26%), Positives = 106/256 (41%), Gaps = 18/256 (7%)
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F +D SG + +DRE++ + ++ T ++I D+ND P F
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFP 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKA-- 746
L I E +P G +A D D G N++ Y + + F+L+ ++ SD +
Sbjct: 135 RQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH---FALDVKKRSDGSLV 191
Query: 747 -ELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
EL+ LD E + Y LV+ A +PP + + V DVNDNAP + +
Sbjct: 192 PELLLEKPLDREK-QSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRIS 250
Query: 803 NYKDCFPVG-PFGRVPAYDADVTDKLQYRI-LSGNN----ANLILLNETTGSMTLSPQLN 856
+ P G ++ A D D+ SG+ NL L+ TTG +TL L+
Sbjct: 251 VLESA-PAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLD 309
Query: 857 TNVPKLATMEVSVTDG 872
+V DG
Sbjct: 310 FESENYYEFDVRARDG 325
>AF152525-1|AAD43785.1| 871|Homo sapiens protocadherin gamma C4
short form protein protein.
Length = 871
Score = 223 bits (546), Expect = 5e-57
Identities = 181/615 (29%), Positives = 290/615 (47%), Gaps = 35/615 (5%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
FR+D SGALL + +DRE + + V++ V I+D ND+ P+
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSA--SCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPR 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSID------ 203
F + + + E + KA DADVG+NS Y + ++ F++D
Sbjct: 133 FPRQQLDLEIGE--AAPPGQRFPLEKAQDADVGSNSISSYRL---SSNEHFALDVKKRSD 187
Query: 204 -SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
SL ++ L K LD E+ YRLV+ A DGG+P RS T +L +++ DVNDNAP F S +
Sbjct: 188 GSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ SV E+ P G ++++ A D D G + +T+ + V ++ P +G + G
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHT-PDRVRNLFSLHPTTGKLTLLG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
LD E++ Y+ V A DGG P + L E PG
Sbjct: 307 PLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPG 366
Query: 383 TPVVTLTATDADEDNRLHYEITGGNTRGRFSITS--QNGRGLITVAQPLDFKQERRYVLT 440
T V ++ D D + + + F++ S +N L+T A PLD + + Y +
Sbjct: 367 TVVALISVQDPDSGSNGDVSLRIPD-HLPFALKSAFRNQFSLVT-AGPLDREAKSSYDIM 424
Query: 441 VSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A+D+G S + +NI+D N+ P F + V E+ G + ++A+D D
Sbjct: 425 VTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDS 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G+NA I+YSL + + A F+ +NPQTGA+ + D E V ARD G
Sbjct: 485 GLNALISYSLLEPRNRDVSA---SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRG 541
Query: 558 VPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDAL-----VGTSVSQVGATDADVG 611
P LS T V + V+D+NDN P V + + ++ AL G +++V A D D G
Sbjct: 542 NPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSG 601
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N + Y+L + + F + +G +RT + + + L V D G+PP S++V
Sbjct: 602 YNAWVSYQL-LEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSV 659
Query: 672 IVHIKIEDINDSPPV 686
+ + +E+ D+ PV
Sbjct: 660 TLLVSLEE--DTHPV 672
Score = 192 bits (467), Expect = 2e-47
Identities = 132/441 (29%), Positives = 214/441 (48%), Gaps = 28/441 (6%)
Query: 370 QYEVELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLIT---V 425
Q ++E+ E PPG A DAD N + N + ++ L+ +
Sbjct: 137 QLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLL 196
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+PLD +++ Y L ++A D G RS TA +++++ D N+ AP F+ + Y SV E AP
Sbjct: 197 EKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAP 256
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G ++ ++A+D D+G + +T+ S + F ++P TG +T LD E+
Sbjct: 257 AGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRV----RNLFSLHPTTGKLTLLGPLDFES 312
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y V ARDGG P++ + + ++DVNDN P + E A GT V+ +
Sbjct: 313 ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALI 372
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPA---SGVIRTNKALDRESVATHDLKAVAI 660
D D G NG + + + F + A + T LDRE+ +++D+ A
Sbjct: 373 SVQDPDSGSNGDVSLRIP----DHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTAS 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
D G PP S+ + + I D+ND+PP F ++ EN+ G + + A DPD G NA
Sbjct: 429 DAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNA 488
Query: 721 VVHYSI---KGGDDSNS--FSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPP 773
++ YS+ + D S S SL + G+ A DYE + ++E+ R +PP
Sbjct: 489 LISYSLLEPRNRDVSASSFISLNPQTGAVHATR----SFDYEQTQTLQFEVQARDRGNPP 544
Query: 774 LWNDVRVEILVTDVNDNAPVM 794
L + V V + V D+NDNAP +
Sbjct: 545 LSSTVTVRLFVLDLNDNAPAV 565
Score = 186 bits (454), Expect = 8e-46
Identities = 158/589 (26%), Positives = 264/589 (44%), Gaps = 54/589 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D NDH+P F QQ + + E A G KA D D+G N+ Y +
Sbjct: 120 EVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFA 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L+ + R DG LL LDREK + Y +++ A D +P
Sbjct: 180 LDVKK----------------RSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA + V+++D NDN P F + +Y +SV E S V+ ++ A+D D+G + +
Sbjct: 223 --SGTAELRVSVLDVNDNAPAFQQSSYRISVLE--SAPAGMVLIQLNASDPDLGPSGNVT 278
Query: 189 YAIIG---GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
+ G + FS+ +G ++L+ LD+E Y +RA+DGGSP+ L +
Sbjct: 279 FYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRV 338
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
++ DVNDNAP + ++ E+ G + + D D G N +++ + D ++
Sbjct: 339 DLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPD-----HL 393
Query: 306 DLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ R+ + + T+G LDRE ++ Y ++VTA+D G+PP S T
Sbjct: 394 PFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTR--GRFSITSQNGR 420
F +EV + E+ PG + +L A+D D + + Y + R S S N +
Sbjct: 454 SFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQ 513
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP-VFENAPYTA 476
G + + D++Q + V A D G S T V++ + D N+ AP V
Sbjct: 514 TGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPG 573
Query: 477 SVFEDA---PIGTTVLV--VSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
S+ A +G L+ V+A D D G NA ++Y L A F ++ G
Sbjct: 574 SLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLE-------APDPSLFAVSRYAG 626
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
+ T + + + L + +D G P LS + + +S+ + D PV
Sbjct: 627 EVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSVTLLVSLEE--DTHPV 672
Score = 140 bits (338), Expect = 9e-32
Identities = 128/495 (25%), Positives = 212/495 (42%), Gaps = 39/495 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+++VLD ND++P F+ Y SV E A +G ++ L A+D D+G + V + T D
Sbjct: 229 RVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPD- 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+++F + +G L LD E Y V+A D SP ++
Sbjct: 288 ---------------RVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQ 332
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S + V+++D NDN P + + ++ E S V+A I D D G+N +
Sbjct: 333 HCS---LRVDLLDVNDNAPYITVTSELGTLPE--SAEPGTVVALISVQDPDSGSNGDVSL 387
Query: 190 AIIGGNTQMQFSIDS-LSGDVSLVKT--LDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F++ S SLV LD E SY +++ A D G+P S + +N
Sbjct: 388 RI---PDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLN 444
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD-KDYTGNV 305
I DVNDN P F+ + V EN G + + A D D G+NA ++Y++ + ++ +
Sbjct: 445 ISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSA 504
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
I+++P++G V+ + D E Q V A D G+PP S+T T
Sbjct: 505 SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPA 564
Query: 366 FM-----PGQY-EVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ PG L G + +TA D D + Y++ F+++
Sbjct: 565 VLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRY 624
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTAS 477
G V P D ++ L + DSG + V + ++ + PV + +++
Sbjct: 625 AGEVRTAVPIPADLPPQK---LVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSA 681
Query: 478 VFEDAPIGTTVLVVS 492
E T L VS
Sbjct: 682 PREGESRLTLYLAVS 696
Score = 125 bits (302), Expect = 2e-27
Identities = 94/303 (31%), Positives = 142/303 (46%), Gaps = 25/303 (8%)
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLT-VTARDGGVPSLSD 563
T SLS+ A + + F ++ +GA+ +DRE + G + + + +
Sbjct: 56 TDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLE 115
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG----RI--- 616
E+ +VDVND+ P F +Q I E A G A DADVG N R+
Sbjct: 116 MYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSN 175
Query: 617 -HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
H+ LD K R +GS V + + K LDRE + + L A+DGG PP+S T + +
Sbjct: 176 EHFALDVKKRSDGSLVPE-----LLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRV 230
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDS--- 732
+ D+ND+ P F+ + E++P G + ++ A DPD GP+ V + G
Sbjct: 231 SVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVR 290
Query: 733 NSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVND 789
N FSL G +L + LD+ES YE +RA SP + + + + DVND
Sbjct: 291 NLFSLHPTTG----KLTLLGPLDFES-ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVND 345
Query: 790 NAP 792
NAP
Sbjct: 346 NAP 348
Score = 79.0 bits (186), Expect = 2e-13
Identities = 66/252 (26%), Positives = 113/252 (44%), Gaps = 24/252 (9%)
Query: 4 PFCIHQQI--NVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
P H+ I N+ D ND+ P F + +E V E G + +L A+D D G NA + Y+
Sbjct: 434 PLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYS 493
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
+ L P + ++ ++GA+ S D E+ V+A D
Sbjct: 494 L-------LEPRNRDVSASSFIS-------LNPQTGAVHATRSFDYEQTQTLQFEVQARD 539
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDI---SVTDNPVIAKIKAT 177
+ +P LSST T+ + ++D NDN P + S+ SV +I K+ A
Sbjct: 540 RGNPP---LSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAV 596
Query: 178 DADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D D G N+ + Y ++ F++ +G+V + + + +LVI +D GSP
Sbjct: 597 DLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPL 655
Query: 238 SNTTQLLINIRD 249
S + LL+++ +
Sbjct: 656 STSVTLLVSLEE 667
Score = 66.9 bits (156), Expect = 1e-09
Identities = 67/256 (26%), Positives = 106/256 (41%), Gaps = 18/256 (7%)
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F +D SG + +DRE++ + ++ T ++I D+ND P F
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFP 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKA-- 746
L I E +P G +A D D G N++ Y + + F+L+ ++ SD +
Sbjct: 135 RQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH---FALDVKKRSDGSLV 191
Query: 747 -ELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
EL+ LD E + Y LV+ A +PP + + V DVNDNAP + +
Sbjct: 192 PELLLEKPLDREK-QSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRIS 250
Query: 803 NYKDCFPVG-PFGRVPAYDADVTDKLQYRI-LSGNN----ANLILLNETTGSMTLSPQLN 856
+ P G ++ A D D+ SG+ NL L+ TTG +TL L+
Sbjct: 251 VLESA-PAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLD 309
Query: 857 TNVPKLATMEVSVTDG 872
+V DG
Sbjct: 310 FESENYYEFDVRARDG 325
>AF152485-1|AAD43746.1| 789|Homo sapiens protocadherin alpha 7
short form protein protein.
Length = 789
Score = 223 bits (546), Expect = 5e-57
Identities = 173/616 (28%), Positives = 280/616 (45%), Gaps = 31/616 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + +R + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVERPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 131 PVFPATQRNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T + + ED PG
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPG 366
Query: 383 TPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRYVL 439
T V+TL + D D ++ ++T T R F + S +N L+ + LD + Y L
Sbjct: 367 T-VITLISV-FDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 440 TVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 424 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDAD 483
Query: 498 VGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD
Sbjct: 484 AQKNALVSYSLVELRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSARDA 540
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDAD 609
GVP L +++ V+D NDN P T + + + G V++V A DAD
Sbjct: 541 GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDAD 600
Query: 610 VGLNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQS 668
G N + YEL P F + +G I T +ALD H L + D G P +
Sbjct: 601 SGYNAWLSYELQPVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLT 660
Query: 669 STVIVHIKIEDINDSP 684
+T V + + + +P
Sbjct: 661 ATATVLVSLVESGQAP 676
Score = 207 bits (505), Expect = 5e-52
Identities = 169/584 (28%), Positives = 268/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 171 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + +L
Sbjct: 278 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ + + E+ G I + +D D GVN ++T ++T +
Sbjct: 338 VEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPR---VP 394
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
L T V S LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 395 FKLVSTFKNYYSLVLDSA-LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HY---EITGGNTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD + N L Y E+ G ++
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAE 513
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT-- 475
G + QPLD ++ VSA D+G +Q+ + D N+ AP AP
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL-LAPRVGG 572
Query: 476 --ASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+V E P G V V A D+D G NA ++Y L + ++ F +
Sbjct: 573 TGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G PSL+ T V +S+V+
Sbjct: 628 TGEISTTRALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVE 671
Score = 206 bits (503), Expect = 9e-52
Identities = 159/549 (28%), Positives = 252/549 (45%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 240 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + V + + D N+ AP +
Sbjct: 300 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ EDA GT + ++S D D G+N Q+T SL+ + + V+ + ++ +
Sbjct: 358 PIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHY---ELDPKDREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y EL +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P + + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ + S+ R G E+ T LD ++PR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQ--PVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 191 bits (466), Expect = 3e-47
Identities = 141/441 (31%), Positives = 225/441 (51%), Gaps = 20/441 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 133 FPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 191
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 192 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 306
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ V + VVDVNDN P + I EDA G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPG 366
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D G+NG++ L P+ + ++ + ALDRESV+ ++L
Sbjct: 367 TVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVV 425
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 426 TARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQ 485
Query: 718 PNAVVHYSI---KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PP 773
NA+V YS+ + G+ + S + S K + +D + E ++++ R A PP
Sbjct: 486 KNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHE-ELELLQFQVSARDAGVPP 544
Query: 774 LWNDVRVEILVTDVNDNAPVM 794
L ++V +++ V D NDNAP +
Sbjct: 545 LGSNVTLQVFVLDENDNAPAL 565
Score = 169 bits (411), Expect = 1e-40
Identities = 122/344 (35%), Positives = 166/344 (48%), Gaps = 15/344 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 119 VDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 179 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 235 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + V +++ D+ND+ P
Sbjct: 295 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ I E++ GT I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLT---PRVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
LD ES YELV+ A SP LW V + V DVNDNAP
Sbjct: 411 SALDRESV-SAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Score = 112 bits (270), Expect = 2e-23
Identities = 91/309 (29%), Positives = 134/309 (43%), Gaps = 19/309 (6%)
Query: 526 INPQTGAITTNKLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQ 584
+N Q G + N +DRE + G + + V V++ V D+NDN PVF
Sbjct: 77 VNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNPPVFPAT 136
Query: 585 LYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVI 639
I E + + GA+DAD+G N + Y L P D + + P V+
Sbjct: 137 QRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVL 196
Query: 640 RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
R K LDRE L A DGG P + TV + I + D ND+ PVF+ T + EN
Sbjct: 197 R--KLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPEN 254
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGG---DDSNSFSLETRQGSDKAELVTMVDLDY 756
IGT + A D DEG N + YS D + F ++ G+ + + +D+
Sbjct: 255 VSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGA----ITVIGHMDF 310
Query: 757 ESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF 813
E R +++ + A PPL V + V DVNDNAP + + +D P
Sbjct: 311 EESRA-HKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI 369
Query: 814 GRVPAYDAD 822
+ +D D
Sbjct: 370 TLISVFDRD 378
>AF152338-1|AAD43732.1| 938|Homo sapiens protocadherin gamma C4
protein.
Length = 938
Score = 223 bits (546), Expect = 5e-57
Identities = 181/615 (29%), Positives = 290/615 (47%), Gaps = 35/615 (5%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
FR+D SGALL + +DRE + + V++ V I+D ND+ P+
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSA--SCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPR 132
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSID------ 203
F + + + E + KA DADVG+NS Y + ++ F++D
Sbjct: 133 FPRQQLDLEIGE--AAPPGQRFPLEKAQDADVGSNSISSYRL---SSNEHFALDVKKRSD 187
Query: 204 -SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
SL ++ L K LD E+ YRLV+ A DGG+P RS T +L +++ DVNDNAP F S +
Sbjct: 188 GSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ SV E+ P G ++++ A D D G + +T+ + V ++ P +G + G
Sbjct: 248 RISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHT-PDRVRNLFSLHPTTGKLTLLG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
LD E++ Y+ V A DGG P + L E PG
Sbjct: 307 PLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPG 366
Query: 383 TPVVTLTATDADEDNRLHYEITGGNTRGRFSITS--QNGRGLITVAQPLDFKQERRYVLT 440
T V ++ D D + + + F++ S +N L+T A PLD + + Y +
Sbjct: 367 TVVALISVQDPDSGSNGDVSLRIPD-HLPFALKSAFRNQFSLVT-AGPLDREAKSSYDIM 424
Query: 441 VSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A+D+G S + +NI+D N+ P F + V E+ G + ++A+D D
Sbjct: 425 VTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDS 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGG 557
G+NA I+YSL + + A F+ +NPQTGA+ + D E V ARD G
Sbjct: 485 GLNALISYSLLEPRNRDVSA---SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRG 541
Query: 558 VPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDAL-----VGTSVSQVGATDADVG 611
P LS T V + V+D+NDN P V + + ++ AL G +++V A D D G
Sbjct: 542 NPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSG 601
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTV 671
N + Y+L + + F + +G +RT + + + L V D G+PP S++V
Sbjct: 602 YNAWVSYQL-LEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSV 659
Query: 672 IVHIKIEDINDSPPV 686
+ + +E+ D+ PV
Sbjct: 660 TLLVSLEE--DTHPV 672
Score = 192 bits (467), Expect = 2e-47
Identities = 132/441 (29%), Positives = 214/441 (48%), Gaps = 28/441 (6%)
Query: 370 QYEVELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLIT---V 425
Q ++E+ E PPG A DAD N + N + ++ L+ +
Sbjct: 137 QLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLL 196
Query: 426 AQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+PLD +++ Y L ++A D G RS TA +++++ D N+ AP F+ + Y SV E AP
Sbjct: 197 EKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAP 256
Query: 484 IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRET 543
G ++ ++A+D D+G + +T+ S + F ++P TG +T LD E+
Sbjct: 257 AGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRV----RNLFSLHPTTGKLTLLGPLDFES 312
Query: 544 MSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQV 603
+ Y V ARDGG P++ + + ++DVNDN P + E A GT V+ +
Sbjct: 313 ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALI 372
Query: 604 GATDADVGLNGRIHYELDPKDREEGSFVIDPA---SGVIRTNKALDRESVATHDLKAVAI 660
D D G NG + + + F + A + T LDRE+ +++D+ A
Sbjct: 373 SVQDPDSGSNGDVSLRIP----DHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTAS 428
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNA 720
D G PP S+ + + I D+ND+PP F ++ EN+ G + + A DPD G NA
Sbjct: 429 DAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNA 488
Query: 721 VVHYSI---KGGDDSNS--FSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPP 773
++ YS+ + D S S SL + G+ A DYE + ++E+ R +PP
Sbjct: 489 LISYSLLEPRNRDVSASSFISLNPQTGAVHATR----SFDYEQTQTLQFEVQARDRGNPP 544
Query: 774 LWNDVRVEILVTDVNDNAPVM 794
L + V V + V D+NDNAP +
Sbjct: 545 LSSTVTVRLFVLDLNDNAPAV 565
Score = 186 bits (454), Expect = 8e-46
Identities = 158/589 (26%), Positives = 264/589 (44%), Gaps = 54/589 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D NDH+P F QQ + + E A G KA D D+G N+ Y +
Sbjct: 120 EVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFA 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGR-SGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L+ + R DG LL LDREK + Y +++ A D +P
Sbjct: 180 LDVKK----------------RSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA + V+++D NDN P F + +Y +SV E S V+ ++ A+D D+G + +
Sbjct: 223 --SGTAELRVSVLDVNDNAPAFQQSSYRISVLE--SAPAGMVLIQLNASDPDLGPSGNVT 278
Query: 189 YAIIG---GNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
+ G + FS+ +G ++L+ LD+E Y +RA+DGGSP+ L +
Sbjct: 279 FYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRV 338
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNV 305
++ DVNDNAP + ++ E+ G + + D D G N +++ + D ++
Sbjct: 339 DLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPD-----HL 393
Query: 306 DLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ R+ + + T+G LDRE ++ Y ++VTA+D G+PP S T
Sbjct: 394 PFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTR--GRFSITSQNGR 420
F +EV + E+ PG + +L A+D D + + Y + R S S N +
Sbjct: 454 SFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQ 513
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP-VFENAPYTA 476
G + + D++Q + V A D G S T V++ + D N+ AP V
Sbjct: 514 TGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPG 573
Query: 477 SVFEDA---PIGTTVLV--VSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTG 531
S+ A +G L+ V+A D D G NA ++Y L A F ++ G
Sbjct: 574 SLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLE-------APDPSLFAVSRYAG 626
Query: 532 AITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPV 580
+ T + + + L + +D G P LS + + +S+ + D PV
Sbjct: 627 EVRTAVPIPAD-LPPQKLVIVVKDSGSPPLSTSVTLLVSLEE--DTHPV 672
Score = 140 bits (338), Expect = 9e-32
Identities = 128/495 (25%), Positives = 212/495 (42%), Gaps = 39/495 (7%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
+++VLD ND++P F+ Y SV E A +G ++ L A+D D+G + V + T D
Sbjct: 229 RVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPD- 287
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
V+++F + +G L LD E Y V+A D SP ++
Sbjct: 288 ---------------RVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQ 332
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
S + V+++D NDN P + + ++ E S V+A I D D G+N +
Sbjct: 333 HCS---LRVDLLDVNDNAPYITVTSELGTLPE--SAEPGTVVALISVQDPDSGSNGDVSL 387
Query: 190 AIIGGNTQMQFSIDS-LSGDVSLVKT--LDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F++ S SLV LD E SY +++ A D G+P S + +N
Sbjct: 388 RI---PDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLN 444
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTD-KDYTGNV 305
I DVNDN P F+ + V EN G + + A D D G+NA ++Y++ + ++ +
Sbjct: 445 ISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSA 504
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
I+++P++G V+ + D E Q V A D G+PP S+T T
Sbjct: 505 SSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPA 564
Query: 366 FM-----PGQY-EVELAEDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ PG L G + +TA D D + Y++ F+++
Sbjct: 565 VLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRY 624
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTAS 477
G V P D ++ L + DSG + V + ++ + PV + +++
Sbjct: 625 AGEVRTAVPIPADLPPQK---LVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSA 681
Query: 478 VFEDAPIGTTVLVVS 492
E T L VS
Sbjct: 682 PREGESRLTLYLAVS 696
Score = 125 bits (302), Expect = 2e-27
Identities = 94/303 (31%), Positives = 142/303 (46%), Gaps = 25/303 (8%)
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLT-VTARDGGVPSLSD 563
T SLS+ A + + F ++ +GA+ +DRE + G + + + +
Sbjct: 56 TDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLE 115
Query: 564 TTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNG----RI--- 616
E+ +VDVND+ P F +Q I E A G A DADVG N R+
Sbjct: 116 MYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSN 175
Query: 617 -HYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
H+ LD K R +GS V + + K LDRE + + L A+DGG PP+S T + +
Sbjct: 176 EHFALDVKKRSDGSLVPE-----LLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRV 230
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDS--- 732
+ D+ND+ P F+ + E++P G + ++ A DPD GP+ V + G
Sbjct: 231 SVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVR 290
Query: 733 NSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVND 789
N FSL G +L + LD+ES YE +RA SP + + + + DVND
Sbjct: 291 NLFSLHPTTG----KLTLLGPLDFES-ENYYEFDVRARDGGSPAMEQHCSLRVDLLDVND 345
Query: 790 NAP 792
NAP
Sbjct: 346 NAP 348
Score = 79.0 bits (186), Expect = 2e-13
Identities = 66/252 (26%), Positives = 113/252 (44%), Gaps = 24/252 (9%)
Query: 4 PFCIHQQI--NVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYT 61
P H+ I N+ D ND+ P F + +E V E G + +L A+D D G NA + Y+
Sbjct: 434 PLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYS 493
Query: 62 IELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATD 121
+ L P + ++ ++GA+ S D E+ V+A D
Sbjct: 494 L-------LEPRNRDVSASSFIS-------LNPQTGAVHATRSFDYEQTQTLQFEVQARD 539
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQ-FSEKTYTVSVDEDI---SVTDNPVIAKIKAT 177
+ +P LSST T+ + ++D NDN P + S+ SV +I K+ A
Sbjct: 540 RGNPP---LSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAV 596
Query: 178 DADVGANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D D G N+ + Y ++ F++ +G+V + + + +LVI +D GSP
Sbjct: 597 DLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPAD-LPPQKLVIVVKDSGSPPL 655
Query: 238 SNTTQLLINIRD 249
S + LL+++ +
Sbjct: 656 STSVTLLVSLEE 667
Score = 66.9 bits (156), Expect = 1e-09
Identities = 67/256 (26%), Positives = 106/256 (41%), Gaps = 18/256 (7%)
Query: 630 FVIDPASGVIRTNKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFE 688
F +D SG + +DRE++ + ++ T ++I D+ND P F
Sbjct: 75 FRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFP 134
Query: 689 SDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKA-- 746
L I E +P G +A D D G N++ Y + + F+L+ ++ SD +
Sbjct: 135 RQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEH---FALDVKKRSDGSLV 191
Query: 747 -ELVTMVDLDYESPRKKYELVIRAA---SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFN 802
EL+ LD E + Y LV+ A +PP + + V DVNDNAP + +
Sbjct: 192 PELLLEKPLDREK-QSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRIS 250
Query: 803 NYKDCFPVG-PFGRVPAYDADVTDKLQYRI-LSGNN----ANLILLNETTGSMTLSPQLN 856
+ P G ++ A D D+ SG+ NL L+ TTG +TL L+
Sbjct: 251 VLESA-PAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLD 309
Query: 857 TNVPKLATMEVSVTDG 872
+V DG
Sbjct: 310 FESENYYEFDVRARDG 325
>AF152315-1|AAD43709.1| 937|Homo sapiens protocadherin alpha 7
protein.
Length = 937
Score = 223 bits (546), Expect = 5e-57
Identities = 173/616 (28%), Positives = 280/616 (45%), Gaps = 31/616 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + +R + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVERPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 131 PVFPATQRNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T + + ED PG
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPG 366
Query: 383 TPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRYVL 439
T V+TL + D D ++ ++T T R F + S +N L+ + LD + Y L
Sbjct: 367 T-VITLISV-FDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 440 TVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 424 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDAD 483
Query: 498 VGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD
Sbjct: 484 AQKNALVSYSLVELRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSARDA 540
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDAD 609
GVP L +++ V+D NDN P T + + + G V++V A DAD
Sbjct: 541 GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDAD 600
Query: 610 VGLNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQS 668
G N + YEL P F + +G I T +ALD H L + D G P +
Sbjct: 601 SGYNAWLSYELQPVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLT 660
Query: 669 STVIVHIKIEDINDSP 684
+T V + + + +P
Sbjct: 661 ATATVLVSLVESGQAP 676
Score = 207 bits (505), Expect = 5e-52
Identities = 169/584 (28%), Positives = 268/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 171 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + +L
Sbjct: 278 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ + + E+ G I + +D D GVN ++T ++T +
Sbjct: 338 VEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPR---VP 394
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
L T V S LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 395 FKLVSTFKNYYSLVLDSA-LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HY---EITGGNTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD + N L Y E+ G ++
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAE 513
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT-- 475
G + QPLD ++ VSA D+G +Q+ + D N+ AP AP
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL-LAPRVGG 572
Query: 476 --ASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+V E P G V V A D+D G NA ++Y L + ++ F +
Sbjct: 573 TGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G PSL+ T V +S+V+
Sbjct: 628 TGEISTTRALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVE 671
Score = 206 bits (503), Expect = 9e-52
Identities = 159/549 (28%), Positives = 252/549 (45%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 240 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + V + + D N+ AP +
Sbjct: 300 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ EDA GT + ++S D D G+N Q+T SL+ + + V+ + ++ +
Sbjct: 358 PIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHY---ELDPKDREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y EL +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P + + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ + S+ R G E+ T LD ++PR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQ--PVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 191 bits (466), Expect = 3e-47
Identities = 141/441 (31%), Positives = 225/441 (51%), Gaps = 20/441 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 133 FPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 191
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 192 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 306
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ V + VVDVNDN P + I EDA G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPG 366
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D G+NG++ L P+ + ++ + ALDRESV+ ++L
Sbjct: 367 TVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVV 425
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 426 TARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQ 485
Query: 718 PNAVVHYSI---KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PP 773
NA+V YS+ + G+ + S + S K + +D + E ++++ R A PP
Sbjct: 486 KNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHE-ELELLQFQVSARDAGVPP 544
Query: 774 LWNDVRVEILVTDVNDNAPVM 794
L ++V +++ V D NDNAP +
Sbjct: 545 LGSNVTLQVFVLDENDNAPAL 565
Score = 169 bits (411), Expect = 1e-40
Identities = 122/344 (35%), Positives = 166/344 (48%), Gaps = 15/344 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 119 VDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 179 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 235 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + V +++ D+ND+ P
Sbjct: 295 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ I E++ GT I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLT---PRVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
LD ES YELV+ A SP LW V + V DVNDNAP
Sbjct: 411 SALDRESV-SAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Score = 112 bits (270), Expect = 2e-23
Identities = 91/309 (29%), Positives = 134/309 (43%), Gaps = 19/309 (6%)
Query: 526 INPQTGAITTNKLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQ 584
+N Q G + N +DRE + G + + V V++ V D+NDN PVF
Sbjct: 77 VNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNPPVFPAT 136
Query: 585 LYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVI 639
I E + + GA+DAD+G N + Y L P D + + P V+
Sbjct: 137 QRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVL 196
Query: 640 RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
R K LDRE L A DGG P + TV + I + D ND+ PVF+ T + EN
Sbjct: 197 R--KLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPEN 254
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGG---DDSNSFSLETRQGSDKAELVTMVDLDY 756
IGT + A D DEG N + YS D + F ++ G+ + + +D+
Sbjct: 255 VSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGA----ITVIGHMDF 310
Query: 757 ESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF 813
E R +++ + A PPL V + V DVNDNAP + + +D P
Sbjct: 311 EESRA-HKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI 369
Query: 814 GRVPAYDAD 822
+ +D D
Sbjct: 370 TLISVFDRD 378
>AC005609-7|AAC34319.1| 789|Homo sapiens KIAA0345-like 7 protein.
Length = 789
Score = 223 bits (546), Expect = 5e-57
Identities = 173/616 (28%), Positives = 280/616 (45%), Gaps = 31/616 (5%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + +R + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVERPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 131 PVFPATQRNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T + + ED PG
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPG 366
Query: 383 TPVVTLTATDADEDNRLHYEITGGNT-RGRFSITS--QNGRGLITVAQPLDFKQERRYVL 439
T V+TL + D D ++ ++T T R F + S +N L+ + LD + Y L
Sbjct: 367 T-VITLISV-FDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLV-LDSALDRESVSAYEL 423
Query: 440 TVSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSD 497
V+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 424 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDAD 483
Query: 498 VGINAQITYSL-SSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
NA ++YSL + A++ + ++ ++G + + LD E + V+ARD
Sbjct: 484 AQKNALVSYSLVELRVGERALSSY---VSVHAESGKVYALQPLDHEELELLQFQVSARDA 540
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLY--TANIMEDAL-----VGTSVSQVGATDAD 609
GVP L +++ V+D NDN P T + + + G V++V A DAD
Sbjct: 541 GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDAD 600
Query: 610 VGLNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQS 668
G N + YEL P F + +G I T +ALD H L + D G P +
Sbjct: 601 SGYNAWLSYELQPVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLT 660
Query: 669 STVIVHIKIEDINDSP 684
+T V + + + +P
Sbjct: 661 ATATVLVSLVESGQAP 676
Score = 207 bits (505), Expect = 5e-52
Identities = 169/584 (28%), Positives = 268/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 171 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + +L
Sbjct: 278 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ + + E+ G I + +D D GVN ++T ++T +
Sbjct: 338 VEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPR---VP 394
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
L T V S LDRE+ + Y+L+VTA DGG P ATA+
Sbjct: 395 FKLVSTFKNYYSLVLDSA-LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Query: 365 XFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HY---EITGGNTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD + N L Y E+ G ++
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAE 513
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYT-- 475
G + QPLD ++ VSA D+G +Q+ + D N+ AP AP
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL-LAPRVGG 572
Query: 476 --ASVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+V E P G V V A D+D G NA ++Y L + ++ F +
Sbjct: 573 TGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD + L V +D G PSL+ T V +S+V+
Sbjct: 628 TGEISTTRALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVE 671
Score = 206 bits (503), Expect = 9e-52
Identities = 159/549 (28%), Positives = 252/549 (45%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 240 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + V + + D N+ AP +
Sbjct: 300 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSL 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+ EDA GT + ++S D D G+N Q+T SL+ + + V+ + ++ +
Sbjct: 358 PIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHY---ELDPKDREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y EL +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P + + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+ ++RA D D G NA + Y ++ + S+ R G E+ T LD ++PR +
Sbjct: 591 VAKVRAVDADSGYNAWLSYELQ--PVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 191 bits (466), Expect = 3e-47
Identities = 141/441 (31%), Positives = 225/441 (51%), Gaps = 20/441 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 133 FPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 191
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 192 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 306
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ V + VVDVNDN P + I EDA G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPG 366
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D G+NG++ L P+ + ++ + ALDRESV+ ++L
Sbjct: 367 TVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLV-LDSALDRESVSAYELVV 425
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 426 TARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQ 485
Query: 718 PNAVVHYSI---KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS-PP 773
NA+V YS+ + G+ + S + S K + +D + E ++++ R A PP
Sbjct: 486 KNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHE-ELELLQFQVSARDAGVPP 544
Query: 774 LWNDVRVEILVTDVNDNAPVM 794
L ++V +++ V D NDNAP +
Sbjct: 545 LGSNVTLQVFVLDENDNAPAL 565
Score = 169 bits (411), Expect = 1e-40
Identities = 122/344 (35%), Positives = 166/344 (48%), Gaps = 15/344 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 119 VDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 179 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 235 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + V +++ D+ND+ P
Sbjct: 295 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTS 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ I E++ GT I I D D G N V S+ F L + + LV
Sbjct: 355 LSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLT---PRVPFKLVSTF-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
LD ES YELV+ A SP LW V + V DVNDNAP
Sbjct: 411 SALDRESV-SAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453
Score = 112 bits (270), Expect = 2e-23
Identities = 91/309 (29%), Positives = 134/309 (43%), Gaps = 19/309 (6%)
Query: 526 INPQTGAITTNKLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQ 584
+N Q G + N +DRE + G + + V V++ V D+NDN PVF
Sbjct: 77 VNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNPPVFPAT 136
Query: 585 LYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASGVI 639
I E + + GA+DAD+G N + Y L P D + + P V+
Sbjct: 137 QRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVL 196
Query: 640 RTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISEN 699
R K LDRE L A DGG P + TV + I + D ND+ PVF+ T + EN
Sbjct: 197 R--KLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPEN 254
Query: 700 SPIGTTIGEIRAHDPDEGPNAVVHYSIKGG---DDSNSFSLETRQGSDKAELVTMVDLDY 756
IGT + A D DEG N + YS D + F ++ G+ + + +D+
Sbjct: 255 VSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGA----ITVIGHMDF 310
Query: 757 ESPRKKYELVIRAAS---PPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPF 813
E R +++ + A PPL V + V DVNDNAP + + +D P
Sbjct: 311 EESRA-HKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI 369
Query: 814 GRVPAYDAD 822
+ +D D
Sbjct: 370 TLISVFDRD 378
>AF217749-1|AAF81913.1| 797|Homo sapiens protocadherin beta 9
protein.
Length = 797
Score = 223 bits (545), Expect = 7e-57
Identities = 180/601 (29%), Positives = 264/601 (43%), Gaps = 26/601 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 77 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVSDINDHSPVFR 134
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS-----LS 206
K + + E+ + + +A D D G NS Y I N+ I +
Sbjct: 135 HKEMVLKISENTA--EGTAFRLERAQDPDEGHNSIQNYTI-SSNSFFHIKISGSDEGMIY 191
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD E+ L + A DGGSPSRS T+ + I + DVNDNAP+F +L++
Sbjct: 192 PELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYETQA 251
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDR 326
EN P+G IV+V A DAD GVNAE++Y+ D + ++ I+P SG ++ LD
Sbjct: 252 PENSPVGSLIVKVSAGDADSGVNAEVSYSFFDA--SEDILTTFQINPFSGEIFLRELLDY 309
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
E Y++ + A DGG SA T + +AE+ PG +
Sbjct: 310 ELVNSYKINIQAMDGGG--LSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLA 366
Query: 387 TLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
D D + F S + ++ LD + + Y +T++ TD
Sbjct: 367 VFKIKDRDSGENGKTICYVQDNLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDM 426
Query: 447 G-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G R T + + ++D N+ AP F YT V E+ + VSATD D G NAQ+
Sbjct: 427 GTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQV 486
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
TYSL + IN G + + LD E + + V A D G P+LS
Sbjct: 487 TYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFDFRVGASDRGSPALSSE 544
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGRIHY 618
V + V+D NDN P L + LV G V++V A D D G N + Y
Sbjct: 545 ALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSY 604
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
+L K E G F + +G +RT + L A H L + D G PP+S+T +H+ +
Sbjct: 605 QL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLV 663
Query: 679 D 679
D
Sbjct: 664 D 664
Score = 194 bits (473), Expect = 4e-48
Identities = 171/594 (28%), Positives = 261/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDHSPVF ++ + E + GT +A D D G N+
Sbjct: 110 MDDPFQIYRAELRVSDINDHSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQN 169
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + D I L+ +LDRE+ ++ + A
Sbjct: 170 YTI------------SSNSFFHIKISGSDEGMI---YPELVLDKALDREEQEELSLTLTA 214
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+TI + ++D NDN PQF++ Y E+ V +I K+ A DA
Sbjct: 215 LDGGSP---SRSGTSTIRIVVLDVNDNAPQFAQALYETQAPENSPV--GSLIVKVSAGDA 269
Query: 180 DVGANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ + + F I+ SG++ L + LDYE V SY++ I+A DGG S
Sbjct: 270 DSGVNAEVSYSFFDASEDILTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGGGLSA 329
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
T +LI + D NDN P S SV+EN P G + + D D G N + +
Sbjct: 330 RCT--VLIKVLDSNDNPPELIISSLSNSVAENSP-GIVLAVFKIKDRDSGENGKTICYVQ 386
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
D +LP + P Y T G LDRE++A+Y + +T TD G P +
Sbjct: 387 D-------NLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDMGTPRLKTEHSITL 439
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 440 QVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 499
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+
Sbjct: 500 LASLVSINADNGH--LFALRSLDYEALQAFDFRVGASDRGSPALSSEALVRVLVLDANDN 557
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 558 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 610
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 174 bits (424), Expect = 3e-42
Identities = 136/462 (29%), Positives = 223/462 (48%), Gaps = 32/462 (6%)
Query: 373 VELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI----TVAQ 427
++++E+ GT A D DE N + N+ I+ + G+I + +
Sbjct: 140 LKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIKISGSD-EGMIYPELVLDK 198
Query: 428 PLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD +++ LT++A D G RS T+ ++I + D N+ AP F A Y E++P+G
Sbjct: 199 ALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYETQAPENSPVG 258
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
+ ++ VSA D+D G+NA+++YS + S + + F INP +G I +LLD E ++
Sbjct: 259 SLIVKVSAGDADSGVNAEVSYSFF-DASEDILT----TFQINPFSGEIFLRELLDYELVN 313
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
Y + + A DGG LS V I V+D NDN P + ++ E++ G ++
Sbjct: 314 SYKINIQAMDGG--GLSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLAVFKI 370
Query: 606 TDADVGLNGR-IHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKAVAID 661
D D G NG+ I Y D F + P+ ++ T ALDRES A +++ D
Sbjct: 371 KDRDSGENGKTICYVQDNLP-----FFLKPSVDNFYILMTEGALDRESKAEYNITITVTD 425
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAV 721
GTP + + +++ D+ND+ P F T ++ EN+ IG + A D D G NA
Sbjct: 426 MGTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQ 485
Query: 722 VHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V YS+ D + + +D L + LDYE+ + ++ + A+ SP L ++
Sbjct: 486 VTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFDFRVGASDRGSPALSSE 544
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
V +LV D NDN+P + + N C + P P Y
Sbjct: 545 ALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 97.9 bits (233), Expect = 5e-19
Identities = 85/279 (30%), Positives = 122/279 (43%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 73 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVSDINDHS 130
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D G N +Y + + G+
Sbjct: 131 PVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIK-ISGSDEGM 189
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T + I + D+ND+ P F
Sbjct: 190 IYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYET 249
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSP+G+ I ++ A D D G NA V YS D S + E+ L
Sbjct: 250 QAPENSPVGSLIVKVSAGDADSGVNAEVSYSF--FDASEDILTTFQINPFSGEIFLRELL 307
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L V I V D NDN P
Sbjct: 308 DYELV-NSYKINIQAMDGGGLSARCTVLIKVLDSNDNPP 345
Score = 74.5 bits (175), Expect = 5e-12
Identities = 73/261 (27%), Positives = 112/261 (42%), Gaps = 17/261 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 69 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVSDIND 128
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF + ISEN+ GT RA DPDEG N++ +Y+I SNSF G
Sbjct: 129 HSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTI----SSNSFFHIKISG 184
Query: 743 SDKAELVTMVDLDYESPRKKYE---LVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKD 796
SD+ + + LD R++ E L + A SP + I+V DVNDNAP
Sbjct: 185 SDEGMIYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQ 244
Query: 797 FQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNANL--ILLNETTGSMTL 851
+ + PVG +V A DAD V ++ Y + L +N +G + L
Sbjct: 245 -ALYETQAPENSPVGSLIVKVSAGDADSGVNAEVSYSFFDASEDILTTFQINPFSGEIFL 303
Query: 852 SPQLNTNVPKLATMEVSVTDG 872
L+ + + + DG
Sbjct: 304 RELLDYELVNSYKINIQAMDG 324
>BC104804-1|AAI04805.1| 950|Homo sapiens protocadherin alpha 9
protein.
Length = 950
Score = 223 bits (544), Expect = 1e-56
Identities = 167/614 (27%), Positives = 273/614 (44%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 131 PVFPATQKNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T V + ED G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 383 TPV--VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + +++ DAD + ++ +T + + T +N L+ + + LD + Y L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLT-PHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADA 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 485 QENALVSYSLVERRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVF-------KQQLYTANIMEDALVGTSVSQVGATDADVG 611
P L +++ V+D NDN P + ++ G V +V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSG 602
Query: 612 LNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P+ F + +G I T +ALD L + D G P ++T
Sbjct: 603 YNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 213 bits (521), Expect = 6e-54
Identities = 159/549 (28%), Positives = 258/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 240 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + + + + D N+ AP +
Sbjct: 300 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSV 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA +GT + ++S D D N Q+T SL+ + + V+ + + ++ +
Sbjct: 358 PVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 RALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+G++RA D D G NA + Y ++ ++ S S+ R G E+ T LD ++PR++
Sbjct: 591 VGKVRAVDADSGYNAWLSYELQ--PETASASIPFRVGLYTGEISTTRALDETDAPRQRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 208 bits (509), Expect = 2e-52
Identities = 163/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 171 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + LL
Sbjct: 278 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ V E+ +G I + D D N ++T ++T +
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGG--NTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 453 PAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHA 512
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRG 572
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ + V G V V A D+D G NA ++Y L E ++ ++ F +
Sbjct: 573 TDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD L V +D G P+L+ T V +S+V+
Sbjct: 628 TGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 191 bits (465), Expect = 4e-47
Identities = 137/440 (31%), Positives = 224/440 (50%), Gaps = 18/440 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 133 FPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 191
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 192 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 306
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ + + VVDVNDN P + + + EDA +G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D NG++ L P + ++ ++ALDRESV+ ++L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELVV 425
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQ 485
Query: 718 PNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPL 774
NA+V YS ++ S S ++ ++ + LD+E ++++ R A PPL
Sbjct: 486 ENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPL 545
Query: 775 WNDVRVEILVTDVNDNAPVM 794
++V +++ V D NDNAP +
Sbjct: 546 GSNVTLQVFVLDENDNAPAL 565
Score = 171 bits (417), Expect = 2e-41
Identities = 138/449 (30%), Positives = 208/449 (46%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 179 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 235 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + + +++ D+ND+ P
Sbjct: 295 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKT 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E++ +GT I I D D N V S+ F L + + LV
Sbjct: 355 LSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLT---PHVPFKLVSTY-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 411 RALDRESV-SAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + ++ R+ + ++ + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 63.3 bits (147), Expect = 1e-08
Identities = 55/210 (26%), Positives = 98/210 (46%), Gaps = 7/210 (3%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + ++LD K R + ++ +G++ N +D
Sbjct: 34 SVPEEAEHGTFVGRI-AQDLGLELAELVPRLFQLDSKGRGD-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V ++++DIND+PPVF + +I+E+ P+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSR 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
A D D G NA++ Y + + + Q LV LD E + + L
Sbjct: 152 FPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLL 211
Query: 766 VIR--AASPPLWNDVRVEILVTDVNDNAPV 793
+ P L V++ I V D NDNAPV
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPV 241
>BC104802-1|AAI04803.1| 950|Homo sapiens protocadherin alpha 9
protein.
Length = 950
Score = 223 bits (544), Expect = 1e-56
Identities = 167/614 (27%), Positives = 273/614 (44%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 131 PVFPATQKNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T V + ED G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 383 TPV--VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + +++ DAD + ++ +T + + T +N L+ + + LD + Y L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLT-PHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADA 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 485 QENALVSYSLVERRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVF-------KQQLYTANIMEDALVGTSVSQVGATDADVG 611
P L +++ V+D NDN P + ++ G V +V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSG 602
Query: 612 LNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P+ F + +G I T +ALD L + D G P ++T
Sbjct: 603 YNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 213 bits (521), Expect = 6e-54
Identities = 159/549 (28%), Positives = 258/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 240 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + + + + D N+ AP +
Sbjct: 300 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSV 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA +GT + ++S D D N Q+T SL+ + + V+ + + ++ +
Sbjct: 358 PVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 RALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+G++RA D D G NA + Y ++ ++ S S+ R G E+ T LD ++PR++
Sbjct: 591 VGKVRAVDADSGYNAWLSYELQ--PETASASIPFRVGLYTGEISTTRALDETDAPRQRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 208 bits (509), Expect = 2e-52
Identities = 163/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 171 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + LL
Sbjct: 278 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ V E+ +G I + D D N ++T ++T +
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGG--NTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 453 PAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHA 512
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRG 572
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ + V G V V A D+D G NA ++Y L E ++ ++ F +
Sbjct: 573 TDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD L V +D G P+L+ T V +S+V+
Sbjct: 628 TGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 191 bits (465), Expect = 4e-47
Identities = 137/440 (31%), Positives = 224/440 (50%), Gaps = 18/440 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 133 FPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 191
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 192 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 306
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ + + VVDVNDN P + + + EDA +G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D NG++ L P + ++ ++ALDRESV+ ++L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELVV 425
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQ 485
Query: 718 PNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPL 774
NA+V YS ++ S S ++ ++ + LD+E ++++ R A PPL
Sbjct: 486 ENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPL 545
Query: 775 WNDVRVEILVTDVNDNAPVM 794
++V +++ V D NDNAP +
Sbjct: 546 GSNVTLQVFVLDENDNAPAL 565
Score = 171 bits (417), Expect = 2e-41
Identities = 138/449 (30%), Positives = 208/449 (46%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 179 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 235 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + + +++ D+ND+ P
Sbjct: 295 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKT 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E++ +GT I I D D N V S+ F L + + LV
Sbjct: 355 LSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLT---PHVPFKLVSTY-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 411 RALDRESV-SAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + ++ R+ + ++ + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 63.3 bits (147), Expect = 1e-08
Identities = 55/210 (26%), Positives = 98/210 (46%), Gaps = 7/210 (3%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + ++LD K R + ++ +G++ N +D
Sbjct: 34 SVPEEAEHGTFVGRI-AQDLGLELAELVPRLFQLDSKGRGD-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V ++++DIND+PPVF + +I+E+ P+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSR 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
A D D G NA++ Y + + + Q LV LD E + + L
Sbjct: 152 FPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLL 211
Query: 766 VIR--AASPPLWNDVRVEILVTDVNDNAPV 793
+ P L V++ I V D NDNAPV
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPV 241
>AJ007610-1|CAC22257.1| 950|Homo sapiens protocadherin alpha 9
protein.
Length = 950
Score = 223 bits (544), Expect = 1e-56
Identities = 167/614 (27%), Positives = 273/614 (44%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 131 PVFPATQKNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T V + ED G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 383 TPV--VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + +++ DAD + ++ +T + + T +N L+ + + LD + Y L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLT-PHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADA 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 485 QENALVSYSLVERRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVF-------KQQLYTANIMEDALVGTSVSQVGATDADVG 611
P L +++ V+D NDN P + ++ G V +V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSG 602
Query: 612 LNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P+ F + +G I T +ALD L + D G P ++T
Sbjct: 603 YNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 213 bits (521), Expect = 6e-54
Identities = 159/549 (28%), Positives = 258/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 240 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + + + + D N+ AP +
Sbjct: 300 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSV 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA +GT + ++S D D N Q+T SL+ + + V+ + + ++ +
Sbjct: 358 PVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 RALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+G++RA D D G NA + Y ++ ++ S S+ R G E+ T LD ++PR++
Sbjct: 591 VGKVRAVDADSGYNAWLSYELQ--PETASASIPFRVGLYTGEISTTRALDETDAPRQRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 208 bits (509), Expect = 2e-52
Identities = 163/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 171 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + LL
Sbjct: 278 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ V E+ +G I + D D N ++T ++T +
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGG--NTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 453 PAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHA 512
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRG 572
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ + V G V V A D+D G NA ++Y L E ++ ++ F +
Sbjct: 573 TDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD L V +D G P+L+ T V +S+V+
Sbjct: 628 TGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 191 bits (465), Expect = 4e-47
Identities = 137/440 (31%), Positives = 224/440 (50%), Gaps = 18/440 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 133 FPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 191
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 192 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 306
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ + + VVDVNDN P + + + EDA +G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D NG++ L P + ++ ++ALDRESV+ ++L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELVV 425
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQ 485
Query: 718 PNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPL 774
NA+V YS ++ S S ++ ++ + LD+E ++++ R A PPL
Sbjct: 486 ENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPL 545
Query: 775 WNDVRVEILVTDVNDNAPVM 794
++V +++ V D NDNAP +
Sbjct: 546 GSNVTLQVFVLDENDNAPAL 565
Score = 171 bits (417), Expect = 2e-41
Identities = 138/449 (30%), Positives = 208/449 (46%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 179 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 235 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + + +++ D+ND+ P
Sbjct: 295 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKT 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E++ +GT I I D D N V S+ F L + + LV
Sbjct: 355 LSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLT---PHVPFKLVSTY-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 411 RALDRESV-SAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + ++ R+ + ++ + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 63.3 bits (147), Expect = 1e-08
Identities = 55/210 (26%), Positives = 98/210 (46%), Gaps = 7/210 (3%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + ++LD K R + ++ +G++ N +D
Sbjct: 34 SVPEEAEHGTFVGRI-AQDLGLELAELVPRLFQLDSKGRGD-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V ++++DIND+PPVF + +I+E+ P+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSR 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
A D D G NA++ Y + + + Q LV LD E + + L
Sbjct: 152 FPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLL 211
Query: 766 VIR--AASPPLWNDVRVEILVTDVNDNAPV 793
+ P L V++ I V D NDNAPV
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPV 241
>AF152487-1|AAD43748.1| 842|Homo sapiens protocadherin alpha 9
short form protein protein.
Length = 842
Score = 223 bits (544), Expect = 1e-56
Identities = 167/614 (27%), Positives = 273/614 (44%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 131 PVFPATQKNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T V + ED G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 383 TPV--VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + +++ DAD + ++ +T + + T +N L+ + + LD + Y L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLT-PHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADA 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 485 QENALVSYSLVERRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVF-------KQQLYTANIMEDALVGTSVSQVGATDADVG 611
P L +++ V+D NDN P + ++ G V +V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSG 602
Query: 612 LNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P+ F + +G I T +ALD L + D G P ++T
Sbjct: 603 YNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 213 bits (521), Expect = 6e-54
Identities = 159/549 (28%), Positives = 258/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 240 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + + + + D N+ AP +
Sbjct: 300 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSV 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA +GT + ++S D D N Q+T SL+ + + V+ + + ++ +
Sbjct: 358 PVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 RALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+G++RA D D G NA + Y ++ ++ S S+ R G E+ T LD ++PR++
Sbjct: 591 VGKVRAVDADSGYNAWLSYELQ--PETASASIPFRVGLYTGEISTTRALDETDAPRQRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 208 bits (509), Expect = 2e-52
Identities = 163/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 171 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + LL
Sbjct: 278 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ V E+ +G I + D D N ++T ++T +
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGG--NTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 453 PAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHA 512
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRG 572
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ + V G V V A D+D G NA ++Y L E ++ ++ F +
Sbjct: 573 TDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD L V +D G P+L+ T V +S+V+
Sbjct: 628 TGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 191 bits (465), Expect = 4e-47
Identities = 137/440 (31%), Positives = 224/440 (50%), Gaps = 18/440 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 133 FPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 191
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 192 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 306
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ + + VVDVNDN P + + + EDA +G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D NG++ L P + ++ ++ALDRESV+ ++L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELVV 425
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQ 485
Query: 718 PNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPL 774
NA+V YS ++ S S ++ ++ + LD+E ++++ R A PPL
Sbjct: 486 ENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPL 545
Query: 775 WNDVRVEILVTDVNDNAPVM 794
++V +++ V D NDNAP +
Sbjct: 546 GSNVTLQVFVLDENDNAPAL 565
Score = 171 bits (417), Expect = 2e-41
Identities = 138/449 (30%), Positives = 208/449 (46%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 179 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 235 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + + +++ D+ND+ P
Sbjct: 295 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKT 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E++ +GT I I D D N V S+ F L + + LV
Sbjct: 355 LSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLT---PHVPFKLVSTY-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 411 RALDRESV-SAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + ++ R+ + ++ + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 63.3 bits (147), Expect = 1e-08
Identities = 55/210 (26%), Positives = 98/210 (46%), Gaps = 7/210 (3%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + ++LD K R + ++ +G++ N +D
Sbjct: 34 SVPEEAEHGTFVGRI-AQDLGLELAELVPRLFQLDSKGRGD-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V ++++DIND+PPVF + +I+E+ P+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSR 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
A D D G NA++ Y + + + Q LV LD E + + L
Sbjct: 152 FPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLL 211
Query: 766 VIR--AASPPLWNDVRVEILVTDVNDNAPV 793
+ P L V++ I V D NDNAPV
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPV 241
>AF152317-1|AAD43711.1| 950|Homo sapiens protocadherin alpha 9
protein.
Length = 950
Score = 223 bits (544), Expect = 1e-56
Identities = 167/614 (27%), Positives = 273/614 (44%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 131 PVFPATQKNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T V + ED G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 383 TPV--VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + +++ DAD + ++ +T + + T +N L+ + + LD + Y L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLT-PHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADA 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 485 QENALVSYSLVERRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVF-------KQQLYTANIMEDALVGTSVSQVGATDADVG 611
P L +++ V+D NDN P + ++ G V +V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSG 602
Query: 612 LNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P+ F + +G I T +ALD L + D G P ++T
Sbjct: 603 YNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 213 bits (521), Expect = 6e-54
Identities = 159/549 (28%), Positives = 258/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 240 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + + + + D N+ AP +
Sbjct: 300 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSV 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA +GT + ++S D D N Q+T SL+ + + V+ + + ++ +
Sbjct: 358 PVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 RALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+G++RA D D G NA + Y ++ ++ S S+ R G E+ T LD ++PR++
Sbjct: 591 VGKVRAVDADSGYNAWLSYELQ--PETASASIPFRVGLYTGEISTTRALDETDAPRQRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 208 bits (509), Expect = 2e-52
Identities = 163/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 171 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + LL
Sbjct: 278 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ V E+ +G I + D D N ++T ++T +
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGG--NTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 453 PAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHA 512
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRG 572
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ + V G V V A D+D G NA ++Y L E ++ ++ F +
Sbjct: 573 TDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD L V +D G P+L+ T V +S+V+
Sbjct: 628 TGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 191 bits (465), Expect = 4e-47
Identities = 137/440 (31%), Positives = 224/440 (50%), Gaps = 18/440 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 133 FPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 191
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 192 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 306
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ + + VVDVNDN P + + + EDA +G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D NG++ L P + ++ ++ALDRESV+ ++L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELVV 425
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQ 485
Query: 718 PNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPL 774
NA+V YS ++ S S ++ ++ + LD+E ++++ R A PPL
Sbjct: 486 ENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPL 545
Query: 775 WNDVRVEILVTDVNDNAPVM 794
++V +++ V D NDNAP +
Sbjct: 546 GSNVTLQVFVLDENDNAPAL 565
Score = 171 bits (417), Expect = 2e-41
Identities = 138/449 (30%), Positives = 208/449 (46%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 179 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 235 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + + +++ D+ND+ P
Sbjct: 295 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKT 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E++ +GT I I D D N V S+ F L + + LV
Sbjct: 355 LSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLT---PHVPFKLVSTY-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 411 RALDRESV-SAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + ++ R+ + ++ + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 63.3 bits (147), Expect = 1e-08
Identities = 55/210 (26%), Positives = 98/210 (46%), Gaps = 7/210 (3%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + ++LD K R + ++ +G++ N +D
Sbjct: 34 SVPEEAEHGTFVGRI-AQDLGLELAELVPRLFQLDSKGRGD-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V ++++DIND+PPVF + +I+E+ P+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSR 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
A D D G NA++ Y + + + Q LV LD E + + L
Sbjct: 152 FPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLL 211
Query: 766 VIR--AASPPLWNDVRVEILVTDVNDNAPV 793
+ P L V++ I V D NDNAPV
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPV 241
>AC005609-5|AAC34313.1| 842|Homo sapiens KIAA0345-like 5 protein.
Length = 842
Score = 223 bits (544), Expect = 1e-56
Identities = 167/614 (27%), Positives = 273/614 (44%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 131 PVFPATQKNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 247
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 248 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 306
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T V + ED G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 383 TPV--VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + +++ DAD + ++ +T + + T +N L+ + + LD + Y L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLT-PHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELV 424
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D+D
Sbjct: 425 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADA 484
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 485 QENALVSYSLVERRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEPVF-------KQQLYTANIMEDALVGTSVSQVGATDADVG 611
P L +++ V+D NDN P + ++ G V +V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSG 602
Query: 612 LNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P+ F + +G I T +ALD L + D G P ++T
Sbjct: 603 YNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVESGQAP 676
Score = 213 bits (521), Expect = 6e-54
Identities = 159/549 (28%), Positives = 258/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 121 VEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 179
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 180 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 240 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 299
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + + + + D N+ AP +
Sbjct: 300 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSV 357
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA +GT + ++S D D N Q+T SL+ + + V+ + + ++ +
Sbjct: 358 PVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYY-------SLVLD 410
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 411 RALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPP 470
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 471 GCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 531 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVV 590
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+G++RA D D G NA + Y ++ ++ S S+ R G E+ T LD ++PR++
Sbjct: 591 VGKVRAVDADSGYNAWLSYELQ--PETASASIPFRVGLYTGEISTTRALDETDAPRQRLL 648
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 649 VLVKDHGEP 657
Score = 208 bits (509), Expect = 2e-52
Identities = 163/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 118 HVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 170
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 171 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 221 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 277
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + LL
Sbjct: 278 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ V E+ +G I + D D N ++T ++T +
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGG--NTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 453 PAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHA 512
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 513 ESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRG 572
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ + V G V V A D+D G NA ++Y L E ++ ++ F +
Sbjct: 573 TDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASI-----PFRVGLY 627
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD L V +D G P+L+ T V +S+V+
Sbjct: 628 TGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 671
Score = 191 bits (465), Expect = 4e-47
Identities = 137/440 (31%), Positives = 224/440 (50%), Gaps = 18/440 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 133 FPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 191
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 192 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 250
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 251 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 306
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ + + VVDVNDN P + + + EDA +G
Sbjct: 307 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 366
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D NG++ L P + ++ ++ALDRESV+ ++L
Sbjct: 367 TVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELVV 425
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQ 485
Query: 718 PNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPL 774
NA+V YS ++ S S ++ ++ + LD+E ++++ R A PPL
Sbjct: 486 ENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPL 545
Query: 775 WNDVRVEILVTDVNDNAPVM 794
++V +++ V D NDNAP +
Sbjct: 546 GSNVTLQVFVLDENDNAPAL 565
Score = 171 bits (417), Expect = 2e-41
Identities = 138/449 (30%), Positives = 208/449 (46%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 178
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 179 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 234
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 235 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 294
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + + +++ D+ND+ P
Sbjct: 295 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKT 354
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E++ +GT I I D D N V S+ F L + + LV
Sbjct: 355 LSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLT---PHVPFKLVSTY-KNYYSLVLD 410
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 411 RALDRESV-SAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNP 469
Query: 809 PVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + ++ R+ + ++ + ++ +G + L+ +
Sbjct: 470 PGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELE 529
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 530 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 558
Score = 63.3 bits (147), Expect = 1e-08
Identities = 55/210 (26%), Positives = 98/210 (46%), Gaps = 7/210 (3%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + ++LD K R + ++ +G++ N +D
Sbjct: 34 SVPEEAEHGTFVGRI-AQDLGLELAELVPRLFQLDSKGRGD-LLEVNLQNGILFVNSRID 91
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V ++++DIND+PPVF + +I+E+ P+ +
Sbjct: 92 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSR 151
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
A D D G NA++ Y + + + Q LV LD E + + L
Sbjct: 152 FPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLL 211
Query: 766 VIR--AASPPLWNDVRVEILVTDVNDNAPV 793
+ P L V++ I V D NDNAPV
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPV 241
>AB002343-1|BAA20803.2| 845|Homo sapiens KIAA0345 protein.
Length = 845
Score = 223 bits (544), Expect = 1e-56
Identities = 167/614 (27%), Positives = 273/614 (44%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DRE++ + + + + DR + V + D NDN
Sbjct: 76 DLLEVNLQNGILFVNSRIDREELCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 133
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG 207
P F + + E + + A+DAD+G N+ + Y + N + + +
Sbjct: 134 PVFPATQKNLFIAESRPLDSRFPLEG--ASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 190
Query: 208 DVS-----LVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLF 262
V L K LD E+ L++ A DGG P + T QLLI + D NDNAP F +L+
Sbjct: 191 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLY 250
Query: 263 QESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSG 322
+ ENV IG ++ A D DEG+N ++ Y+ + D + ++ +DP SG + G
Sbjct: 251 TVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFS-SDVSPDIKSKFHMDPLSGAITVIG 309
Query: 323 QLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPG 382
+D E +++ V A D G PP + T V + ED G
Sbjct: 310 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 369
Query: 383 TPV--VTLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
T + +++ DAD + ++ +T + + T +N L+ + + LD + Y L
Sbjct: 370 TVIALISVIDLDADANGQVTCSLT-PHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELV 427
Query: 441 VSATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
V+A D G S TA V + + D N+ AP F + YT V E+ P G + VSA D+D
Sbjct: 428 VTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADA 487
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL E ++ ++G + + LD E + V+ARD GV
Sbjct: 488 QENALVSYSLVERRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 545
Query: 559 PSLSDTTDVEISVVDVNDNEPVF-------KQQLYTANIMEDALVGTSVSQVGATDADVG 611
P L +++ V+D NDN P + ++ G V +V A DAD G
Sbjct: 546 PPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSG 605
Query: 612 LNGRIHYELDPKDREEG-SFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P+ F + +G I T +ALD L + D G P ++T
Sbjct: 606 YNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 665
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 666 ATVLVSLVESGQAP 679
Score = 213 bits (521), Expect = 6e-54
Identities = 159/549 (28%), Positives = 258/549 (46%), Gaps = 32/549 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + ++E+ P+ A DAD G NA LTY ++ +Y
Sbjct: 124 VEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFF- 182
Query: 305 VDLPITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+P + + + LDRE + LL+TATDGG P + T
Sbjct: 183 LDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNA 242
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGG---NTRGRFSITSQN 418
F Y V+L E+ GT V+ A+D DE + + Y + + + +F + +
Sbjct: 243 PVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLS 302
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTA 476
G ITV +DF++ R + + V A D G + + + + D N+ AP +
Sbjct: 303 GA--ITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSV 360
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
V EDA +GT + ++S D D N Q+T SL+ + + V+ + + ++ +
Sbjct: 361 PVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYY-------SLVLD 413
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E+
Sbjct: 414 RALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPP 473
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRESVAT 652
G + V A DAD N + Y L + +R S+V + SG + + LD E +
Sbjct: 474 GCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELEL 533
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSPIGTT 705
+ A D G PP S V + + + D ND+ P ++ + + G
Sbjct: 534 LQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVV 593
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLD-YESPRKKYE 764
+G++RA D D G NA + Y ++ ++ S S+ R G E+ T LD ++PR++
Sbjct: 594 VGKVRAVDADSGYNAWLSYELQ--PETASASIPFRVGLYTGEISTTRALDETDAPRQRLL 651
Query: 765 LVIRAASPP 773
++++ P
Sbjct: 652 VLVKDHGEP 660
Score = 208 bits (509), Expect = 2e-52
Identities = 163/584 (27%), Positives = 265/584 (45%), Gaps = 48/584 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF Q + E + A+D DIG+NA + Y
Sbjct: 121 HVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTY------- 173
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
L+P + Q V + L+ R LDRE+ +L+ ATD P
Sbjct: 174 -RLSPNEYFFLDVPTSN--QQV-----KPLGLVLRKLLDREETPELHLLLTATDGGKP-- 223
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ T + + ++D+NDN P F YTV + E++S+ ++ A+D D G N I
Sbjct: 224 -ELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSI--GTLVIHPNASDLDEGLNGDI 280
Query: 188 RYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y+ + + + +F +D LSG ++++ +D+E+ R++++ + A D G P + LL
Sbjct: 281 IYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLL 340
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDNAP+ V E+ +G I + D D N ++T ++T +
Sbjct: 341 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP-----H 395
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 396 VPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 455
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGG--NTRGRFSITSQNG 419
F +Y V + E+ PPG + T++A DAD ++N L Y + R S S +
Sbjct: 456 PAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHA 515
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVF------- 469
G + QPLD ++ VSA D+G +Q+ + D N+ AP
Sbjct: 516 ESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRG 575
Query: 470 ENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
+ + V G V V A D+D G NA ++Y L E ++ ++ F +
Sbjct: 576 TDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASI-----PFRVGLY 630
Query: 530 TGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T + LD L V +D G P+L+ T V +S+V+
Sbjct: 631 TGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 674
Score = 191 bits (465), Expect = 4e-47
Identities = 137/440 (31%), Positives = 224/440 (50%), Gaps = 18/440 (4%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGR--- 420
F Q + +AE P + A+DAD E+ L Y ++ N + + N +
Sbjct: 136 FPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSP-NEYFFLDVPTSNQQVKP 194
Query: 421 -GLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTAS 477
GL+ + + LD ++ L ++ATD G T VQ+ IT D N+ APVF+ YT
Sbjct: 195 LGLV-LRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVK 253
Query: 478 VFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNK 537
+ E+ IGT V+ +A+D D G+N I YS SS++S + + +F ++P +GAIT
Sbjct: 254 LPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKS----KFHMDPLSGAITVIG 309
Query: 538 LLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVG 597
+D E + + V A D G P L+ + + VVDVNDN P + + + EDA +G
Sbjct: 310 HMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLG 369
Query: 598 TSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
T ++ + D D NG++ L P + ++ ++ALDRESV+ ++L
Sbjct: 370 TVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLV-LDRALDRESVSAYELVV 428
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D
Sbjct: 429 TARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQ 488
Query: 718 PNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPL 774
NA+V YS ++ S S ++ ++ + LD+E ++++ R A PPL
Sbjct: 489 ENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPL 548
Query: 775 WNDVRVEILVTDVNDNAPVM 794
++V +++ V D NDNAP +
Sbjct: 549 GSNVTLQVFVLDENDNAPAL 568
Score = 171 bits (417), Expect = 2e-41
Identities = 138/449 (30%), Positives = 208/449 (46%), Gaps = 23/449 (5%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLS-SEIS 513
V + + D N+ PVF + E P+ + + A+D+D+G NA +TY LS +E
Sbjct: 122 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYF 181
Query: 514 NEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
V +QQ + P + KLLDRE L +TA DGG P L+ T + I+V+D
Sbjct: 182 FLDVPTSNQQ--VKPL--GLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLD 237
Query: 574 VNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYEL--DPKDREEGSFV 631
NDN PVF + LYT + E+ +GT V A+D D GLNG I Y D + F
Sbjct: 238 NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFH 297
Query: 632 IDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDC 691
+DP SG I +D E H + A+D G PP + + +++ D+ND+ P
Sbjct: 298 MDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKT 357
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTM 751
L+ + E++ +GT I I D D N V S+ F L + + LV
Sbjct: 358 LSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLT---PHVPFKLVSTY-KNYYSLVLD 413
Query: 752 VDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCF 808
LD ES YELV+ A SP LW RV + V DVNDNAP + ++
Sbjct: 414 RALDRESV-SAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNP 472
Query: 809 PVGPFGRVPAYDADVTDK-------LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPK 861
P V A DAD + ++ R+ + ++ + ++ +G + L+ +
Sbjct: 473 PGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELE 532
Query: 862 LATMEVSVTD-GVNEIKAMMQLSVRLITE 889
L +VS D GV + + + L V ++ E
Sbjct: 533 LLQFQVSARDAGVPPLGSNVTLQVFVLDE 561
Score = 63.3 bits (147), Expect = 1e-08
Identities = 55/210 (26%), Positives = 98/210 (46%), Gaps = 7/210 (3%)
Query: 589 NIMEDALVGTSVSQVGATDADVGLNGRIH--YELDPKDREEGSFVIDPASGVIRTNKALD 646
++ E+A GT V ++ A D + L + ++LD K R + ++ +G++ N +D
Sbjct: 37 SVPEEAEHGTFVGRI-AQDLGLELAELVPRLFQLDSKGRGD-LLEVNLQNGILFVNSRID 94
Query: 647 RESVATHDLK-AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
RE + + ++ ++ V ++++DIND+PPVF + +I+E+ P+ +
Sbjct: 95 REELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSR 154
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYEL 765
A D D G NA++ Y + + + Q LV LD E + + L
Sbjct: 155 FPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLL 214
Query: 766 VIR--AASPPLWNDVRVEILVTDVNDNAPV 793
+ P L V++ I V D NDNAPV
Sbjct: 215 LTATDGGKPELTGTVQLLITVLDNNDNAPV 244
>BC105640-1|AAI05641.1| 797|Homo sapiens protocadherin beta 9
protein.
Length = 797
Score = 222 bits (543), Expect = 1e-56
Identities = 180/601 (29%), Positives = 264/601 (43%), Gaps = 26/601 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 77 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVRDINDHSPVFR 134
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS-----LS 206
K + + E+ + + +A D D G NS Y I N+ I +
Sbjct: 135 HKEMVLKISENTA--EGTAFRLERAQDPDEGHNSIQNYTI-SSNSFFHIKISGSDEGMIY 191
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD E+ L + A DGGSPSRS T+ + I + DVNDNAP+F +L++
Sbjct: 192 PELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYETQA 251
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDR 326
EN P+G IV+V A DAD GVNAE++Y+ D + ++ I+P SG ++ LD
Sbjct: 252 PENSPVGSLIVKVSAGDADSGVNAEVSYSFFDA--SEDILTTFQINPFSGEIFLRELLDY 309
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
E Y++ + A DGG SA T + +AE+ PG +
Sbjct: 310 ELVNSYKINIQAMDGGG--LSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLA 366
Query: 387 TLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
D D + F S + ++ LD + + Y +T++ TD
Sbjct: 367 VFKIKDRDSGENGKTICYVQDNLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDL 426
Query: 447 G-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G R T + + ++D N+ AP F YT V E+ + VSATD D G NAQ+
Sbjct: 427 GTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQV 486
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
TYSL + IN G + + LD E + + V A D G P+LS
Sbjct: 487 TYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFDFRVGASDRGSPALSSE 544
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGRIHY 618
V + V+D NDN P L + LV G V++V A D D G N + Y
Sbjct: 545 ALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSY 604
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
+L K E G F + +G +RT + L A H L + D G PP+S+T +H+ +
Sbjct: 605 QL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLV 663
Query: 679 D 679
D
Sbjct: 664 D 664
Score = 194 bits (472), Expect = 5e-48
Identities = 171/594 (28%), Positives = 261/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDHSPVF ++ + E + GT +A D D G N+
Sbjct: 110 MDDPFQIYRAELRVRDINDHSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQN 169
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + D I L+ +LDRE+ ++ + A
Sbjct: 170 YTI------------SSNSFFHIKISGSDEGMI---YPELVLDKALDREEQEELSLTLTA 214
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+TI + ++D NDN PQF++ Y E+ V +I K+ A DA
Sbjct: 215 LDGGSP---SRSGTSTIRIVVLDVNDNAPQFAQALYETQAPENSPV--GSLIVKVSAGDA 269
Query: 180 DVGANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ + + F I+ SG++ L + LDYE V SY++ I+A DGG S
Sbjct: 270 DSGVNAEVSYSFFDASEDILTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGGGLSA 329
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
T +LI + D NDN P S SV+EN P G + + D D G N + +
Sbjct: 330 RCT--VLIKVLDSNDNPPELIISSLSNSVAENSP-GIVLAVFKIKDRDSGENGKTICYVQ 386
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
D +LP + P Y T G LDRE++A+Y + +T TD G P +
Sbjct: 387 D-------NLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDLGTPRLKTEHSITL 439
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 440 QVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 499
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+
Sbjct: 500 LASLVSINADNGH--LFALRSLDYEALQAFDFRVGASDRGSPALSSEALVRVLVLDANDN 557
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 558 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 610
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 174 bits (423), Expect = 4e-42
Identities = 136/462 (29%), Positives = 223/462 (48%), Gaps = 32/462 (6%)
Query: 373 VELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI----TVAQ 427
++++E+ GT A D DE N + N+ I+ + G+I + +
Sbjct: 140 LKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIKISGSD-EGMIYPELVLDK 198
Query: 428 PLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD +++ LT++A D G RS T+ ++I + D N+ AP F A Y E++P+G
Sbjct: 199 ALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYETQAPENSPVG 258
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
+ ++ VSA D+D G+NA+++YS + S + + F INP +G I +LLD E ++
Sbjct: 259 SLIVKVSAGDADSGVNAEVSYSFF-DASEDILT----TFQINPFSGEIFLRELLDYELVN 313
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
Y + + A DGG LS V I V+D NDN P + ++ E++ G ++
Sbjct: 314 SYKINIQAMDGG--GLSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLAVFKI 370
Query: 606 TDADVGLNGR-IHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKAVAID 661
D D G NG+ I Y D F + P+ ++ T ALDRES A +++ D
Sbjct: 371 KDRDSGENGKTICYVQDNLP-----FFLKPSVDNFYILMTEGALDRESKAEYNITITVTD 425
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAV 721
GTP + + +++ D+ND+ P F T ++ EN+ IG + A D D G NA
Sbjct: 426 LGTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQ 485
Query: 722 VHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V YS+ D + + +D L + LDYE+ + ++ + A+ SP L ++
Sbjct: 486 VTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFDFRVGASDRGSPALSSE 544
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
V +LV D NDN+P + + N C + P P Y
Sbjct: 545 ALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 97.5 bits (232), Expect = 6e-19
Identities = 85/279 (30%), Positives = 122/279 (43%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 73 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVRDINDHS 130
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D G N +Y + + G+
Sbjct: 131 PVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIK-ISGSDEGM 189
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T + I + D+ND+ P F
Sbjct: 190 IYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYET 249
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSP+G+ I ++ A D D G NA V YS D S + E+ L
Sbjct: 250 QAPENSPVGSLIVKVSAGDADSGVNAEVSYSF--FDASEDILTTFQINPFSGEIFLRELL 307
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L V I V D NDN P
Sbjct: 308 DYELV-NSYKINIQAMDGGGLSARCTVLIKVLDSNDNPP 345
Score = 74.5 bits (175), Expect = 5e-12
Identities = 73/261 (27%), Positives = 112/261 (42%), Gaps = 17/261 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 69 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDIND 128
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF + ISEN+ GT RA DPDEG N++ +Y+I SNSF G
Sbjct: 129 HSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTI----SSNSFFHIKISG 184
Query: 743 SDKAELVTMVDLDYESPRKKYE---LVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKD 796
SD+ + + LD R++ E L + A SP + I+V DVNDNAP
Sbjct: 185 SDEGMIYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQ 244
Query: 797 FQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNANL--ILLNETTGSMTL 851
+ + PVG +V A DAD V ++ Y + L +N +G + L
Sbjct: 245 -ALYETQAPENSPVGSLIVKVSAGDADSGVNAEVSYSFFDASEDILTTFQINPFSGEIFL 303
Query: 852 SPQLNTNVPKLATMEVSVTDG 872
L+ + + + DG
Sbjct: 304 RELLDYELVNSYKINIQAMDG 324
>BC103494-1|AAI03495.1| 796|Homo sapiens PCDHB9 protein protein.
Length = 796
Score = 222 bits (543), Expect = 1e-56
Identities = 180/601 (29%), Positives = 264/601 (43%), Gaps = 26/601 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 76 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVRDINDHSPVFR 133
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS-----LS 206
K + + E+ + + +A D D G NS Y I N+ I +
Sbjct: 134 HKEMVLKISENTA--EGTAFRLERAQDPDEGHNSIQNYTI-SSNSFFHIKISGSDEGMIY 190
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD E+ L + A DGGSPSRS T+ + I + DVNDNAP+F +L++
Sbjct: 191 PELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYETQA 250
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDR 326
EN P+G IV+V A DAD GVNAE++Y+ D + ++ I+P SG ++ LD
Sbjct: 251 PENSPVGSLIVKVSAGDADSGVNAEVSYSFFDA--SEDILTTFQINPFSGEIFLRELLDY 308
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
E Y++ + A DGG SA T + +AE+ PG +
Sbjct: 309 ELVNSYKINIQAMDGGG--LSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLA 365
Query: 387 TLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
D D + F S + ++ LD + + Y +T++ TD
Sbjct: 366 VFKIKDRDSGENGKTICYVQDNLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDL 425
Query: 447 G-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G R T + + ++D N+ AP F YT V E+ + VSATD D G NAQ+
Sbjct: 426 GTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQV 485
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
TYSL + IN G + + LD E + + V A D G P+LS
Sbjct: 486 TYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFDFRVGASDRGSPALSSE 543
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGRIHY 618
V + V+D NDN P L + LV G V++V A D D G N + Y
Sbjct: 544 ALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSY 603
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
+L K E G F + +G +RT + L A H L + D G PP+S+T +H+ +
Sbjct: 604 QL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLV 662
Query: 679 D 679
D
Sbjct: 663 D 663
Score = 194 bits (472), Expect = 5e-48
Identities = 171/594 (28%), Positives = 261/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDHSPVF ++ + E + GT +A D D G N+
Sbjct: 109 MDDPFQIYRAELRVRDINDHSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQN 168
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + D I L+ +LDRE+ ++ + A
Sbjct: 169 YTI------------SSNSFFHIKISGSDEGMI---YPELVLDKALDREEQEELSLTLTA 213
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+TI + ++D NDN PQF++ Y E+ V +I K+ A DA
Sbjct: 214 LDGGSP---SRSGTSTIRIVVLDVNDNAPQFAQALYETQAPENSPV--GSLIVKVSAGDA 268
Query: 180 DVGANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ + + F I+ SG++ L + LDYE V SY++ I+A DGG S
Sbjct: 269 DSGVNAEVSYSFFDASEDILTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGGGLSA 328
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
T +LI + D NDN P S SV+EN P G + + D D G N + +
Sbjct: 329 RCT--VLIKVLDSNDNPPELIISSLSNSVAENSP-GIVLAVFKIKDRDSGENGKTICYVQ 385
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
D +LP + P Y T G LDRE++A+Y + +T TD G P +
Sbjct: 386 D-------NLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDLGTPRLKTEHSITL 438
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 439 QVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 498
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+
Sbjct: 499 LASLVSINADNGH--LFALRSLDYEALQAFDFRVGASDRGSPALSSEALVRVLVLDANDN 556
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 557 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 609
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 610 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 663
Score = 174 bits (423), Expect = 4e-42
Identities = 136/462 (29%), Positives = 223/462 (48%), Gaps = 32/462 (6%)
Query: 373 VELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI----TVAQ 427
++++E+ GT A D DE N + N+ I+ + G+I + +
Sbjct: 139 LKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIKISGSD-EGMIYPELVLDK 197
Query: 428 PLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD +++ LT++A D G RS T+ ++I + D N+ AP F A Y E++P+G
Sbjct: 198 ALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYETQAPENSPVG 257
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
+ ++ VSA D+D G+NA+++YS + S + + F INP +G I +LLD E ++
Sbjct: 258 SLIVKVSAGDADSGVNAEVSYSFF-DASEDILT----TFQINPFSGEIFLRELLDYELVN 312
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
Y + + A DGG LS V I V+D NDN P + ++ E++ G ++
Sbjct: 313 SYKINIQAMDGG--GLSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLAVFKI 369
Query: 606 TDADVGLNGR-IHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKAVAID 661
D D G NG+ I Y D F + P+ ++ T ALDRES A +++ D
Sbjct: 370 KDRDSGENGKTICYVQDNLP-----FFLKPSVDNFYILMTEGALDRESKAEYNITITVTD 424
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAV 721
GTP + + +++ D+ND+ P F T ++ EN+ IG + A D D G NA
Sbjct: 425 LGTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQ 484
Query: 722 VHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V YS+ D + + +D L + LDYE+ + ++ + A+ SP L ++
Sbjct: 485 VTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFDFRVGASDRGSPALSSE 543
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
V +LV D NDN+P + + N C + P P Y
Sbjct: 544 ALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 583
Score = 97.5 bits (232), Expect = 6e-19
Identities = 85/279 (30%), Positives = 122/279 (43%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 72 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVRDINDHS 129
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D G N +Y + + G+
Sbjct: 130 PVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIK-ISGSDEGM 188
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T + I + D+ND+ P F
Sbjct: 189 IYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYET 248
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSP+G+ I ++ A D D G NA V YS D S + E+ L
Sbjct: 249 QAPENSPVGSLIVKVSAGDADSGVNAEVSYSF--FDASEDILTTFQINPFSGEIFLRELL 306
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L V I V D NDN P
Sbjct: 307 DYELV-NSYKINIQAMDGGGLSARCTVLIKVLDSNDNPP 344
Score = 74.5 bits (175), Expect = 5e-12
Identities = 73/261 (27%), Positives = 112/261 (42%), Gaps = 17/261 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 68 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDIND 127
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF + ISEN+ GT RA DPDEG N++ +Y+I SNSF G
Sbjct: 128 HSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTI----SSNSFFHIKISG 183
Query: 743 SDKAELVTMVDLDYESPRKKYE---LVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKD 796
SD+ + + LD R++ E L + A SP + I+V DVNDNAP
Sbjct: 184 SDEGMIYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQ 243
Query: 797 FQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNANL--ILLNETTGSMTL 851
+ + PVG +V A DAD V ++ Y + L +N +G + L
Sbjct: 244 -ALYETQAPENSPVGSLIVKVSAGDADSGVNAEVSYSFFDASEDILTTFQINPFSGEIFL 302
Query: 852 SPQLNTNVPKLATMEVSVTDG 872
L+ + + + DG
Sbjct: 303 RELLDYELVNSYKINIQAMDG 323
>BC071934-1|AAH71934.1| 798|Homo sapiens protocadherin beta 13
protein.
Length = 798
Score = 222 bits (543), Expect = 1e-56
Identities = 183/606 (30%), Positives = 267/606 (44%), Gaps = 35/606 (5%)
Query: 91 RIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQF 150
+++ + LL LDRE + +T Q S A + V ID ND+ P F
Sbjct: 77 QLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQV--IDINDHSPVF 134
Query: 151 SEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG--- 207
+K V V E S A D DVG N+ Y II N+ + S
Sbjct: 135 LDKQMLVKVSE--SSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRVLTRKRSDGRK 191
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L K LD E+ RL + A DGGSP RS T Q+ I + DVNDNAP F ++
Sbjct: 192 YPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQ 251
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SE+ P+G+ +V+V A D D GVN E++Y++ + + I+P +G + QLD
Sbjct: 252 ISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQA--SEEIGKTFKINPLTGEIELKKQLD 309
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E Y++ + A D G S T + + E+ P T V
Sbjct: 310 FEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPE-TVV 366
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ +D D E+ ++ I F + S + +PLD + Y +T++
Sbjct: 367 ALFSVSDLDSGENGKISCSIQEDLP---FLLKSAENFYTLLTERPLDRESRAEYNITITV 423
Query: 444 TDSGGRSDTAMVQINIT----DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
TD G + + Q+N+T D N+ AP F YT V E+ + VSATD D G
Sbjct: 424 TDLG--TPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 500 INAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
NAQ+TYSL + IN G + + LD E + G+ V A D G P
Sbjct: 482 TNAQVTYSLLP--PQDPHLPLTSLVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSP 539
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLN 613
+LS V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 540 ALSSEALVRVVVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +
Sbjct: 600 AWLSYQL-LKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 674 HIKIED 679
H+ + D
Sbjct: 659 HVLLVD 664
Score = 202 bits (492), Expect = 2e-50
Identities = 148/466 (31%), Positives = 230/466 (49%), Gaps = 27/466 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGL- 422
F+ Q V+++E PPGT A D D ++N +Y I+ + + +GR
Sbjct: 134 FLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYP 193
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD ++E LT++A D G RS TA V I + D N+ AP FE Y +
Sbjct: 194 ELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQIS 253
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
ED+P+G V+ VSATD D G+N +I+YSL ++E + + F INP TG I K L
Sbjct: 254 EDSPVGFLVVKVSATDVDTGVNGEISYSLFQ--ASEEIG---KTFKINPLTGEIELKKQL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARD G + S V I V+DVND+ P +T+ I E+A T
Sbjct: 309 DFEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENA-PETV 365
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--VIRTNKALDRESVATHDLKA 657
V+ +D D G NG+I + +E+ F++ A + T + LDRES A +++
Sbjct: 366 VALFSVSDLDSGENGKISCSI----QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + I D+ND+ P F T ++ EN+ I + A D D G
Sbjct: 422 TVTDLGTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPP 773
NA V YS+ D + + +D L + LDYE+ + ++ + A+ SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEA-LQGFQFRVGASDHGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V ++V D NDN+P + + N C + P P Y
Sbjct: 541 LSSEALVRVVVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 199 bits (485), Expect = 1e-49
Identities = 172/593 (29%), Positives = 271/593 (45%), Gaps = 65/593 (10%)
Query: 4 PFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
PF Q ++ V+D NDHSPVF +Q V E + GTT A D D+G+N Y I
Sbjct: 114 PFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYII 173
Query: 63 ELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATD 121
+P V R DGR L+ +LDRE+ A + + A D
Sbjct: 174 --------SPN--------SYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALD 217
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
SP S TA +++ ++D NDN P+F + Y V + ED V ++ K+ ATD D
Sbjct: 218 GGSPPR---SGTAQVYIEVLDVNDNAPEFEQPFYRVQISEDSPV--GFLVVKVSATDVDT 272
Query: 182 GANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
G N I Y++ + ++ F I+ L+G++ L K LD+E+++SY + I A+D G+ S
Sbjct: 273 GVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGKC 332
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
T +LI + DVND+AP S F + EN P + D D G N +++ ++ +
Sbjct: 333 T--VLIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQE- 388
Query: 300 DYTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
DLP + + + T LDRE++A+Y + +T TD G P
Sbjct: 389 ------DLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 358 XXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN-----TRG 410
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV 468
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+ +P
Sbjct: 503 LVSINADNGH--LFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 469 ----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL--SSEISNEAVAHH 520
+N AP T V A G V V A D D G NA ++Y L ++E+ V H
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ G + T +LL + + L V +D G P S T + + +VD
Sbjct: 621 N---------GEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 142 bits (343), Expect = 2e-32
Identities = 135/497 (27%), Positives = 213/497 (42%), Gaps = 49/497 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND++P FE Y + E + G V+ + ATD D G N E+ Y++ + +
Sbjct: 231 IEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEE-- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F+I+ +G + + LD EK+ Y V ++A D +
Sbjct: 289 ---------------IGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT-----F 328
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S T+ + +ID ND+ P+ + +T + E+ T V+A +D D G N I +
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPET---VVALFSVSDLDSGENGKISCS 385
Query: 191 IIGGNTQMQFSIDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
I + F + S +L+ + LD E Y + I D G+P + + I
Sbjct: 386 I---QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTGNVDL 307
DVNDNAP F + + V EN I V A D D G NA++TY+ + +D +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++I+ +G ++ LD E +Q V A+D G P S+ A +
Sbjct: 503 LVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVL 562
Query: 368 -PGQY-EVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNG 419
P Q E P PG V + A D D L Y++ G F + + NG
Sbjct: 563 YPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNG 622
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITD--ANNYAPVFENAPYT 475
+ A+ L + ++ L V D+G RS TA + + + D + Y P+ E AP
Sbjct: 623 E--VRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPTQ 680
Query: 476 ASVFEDAPIGTTVLVVS 492
A A + T LVV+
Sbjct: 681 A----QADLLTVYLVVA 693
Score = 67.3 bits (157), Expect = 7e-10
Identities = 68/238 (28%), Positives = 101/238 (42%), Gaps = 15/238 (6%)
Query: 642 NKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENS 700
N+ LDRE + H V +++ DIND PVF + +SE+S
Sbjct: 88 NEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESS 147
Query: 701 PIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV--TMVDLDYES 758
P GTT A D D G N + +Y I + + G ELV +D + E+
Sbjct: 148 PPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEA 207
Query: 759 PRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYK--DCFPVG-PFGR 815
+ + SPP +V I V DVNDNAP +F+ F + + PVG +
Sbjct: 208 ELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAP---EFEQPFYRVQISEDSPVGFLVVK 264
Query: 816 VPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
V A D D V ++ Y + + +N TG + L QL + KL + EV++
Sbjct: 265 VSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQL--DFEKLQSYEVNI 320
>BC051348-1|AAH51348.1| 798|Homo sapiens protocadherin beta 13
protein.
Length = 798
Score = 222 bits (543), Expect = 1e-56
Identities = 183/606 (30%), Positives = 267/606 (44%), Gaps = 35/606 (5%)
Query: 91 RIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQF 150
+++ + LL LDRE + +T Q S A + V ID ND+ P F
Sbjct: 77 QLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQV--IDINDHSPVF 134
Query: 151 SEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG--- 207
+K V V E S A D DVG N+ Y II N+ + S
Sbjct: 135 LDKQMLVKVSE--SSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRVLTRKRSDGRK 191
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L K LD E+ RL + A DGGSP RS T Q+ I + DVNDNAP F ++
Sbjct: 192 YPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQ 251
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SE+ P+G+ +V+V A D D GVN E++Y++ + + I+P +G + QLD
Sbjct: 252 ISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQA--SEEIGKTFKINPLTGEIELKKQLD 309
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E Y++ + A D G S T + + E+ P T V
Sbjct: 310 FEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPE-TVV 366
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ +D D E+ ++ I F + S + +PLD + Y +T++
Sbjct: 367 ALFSVSDLDSGENGKISCSIQEDLP---FLLKSAENFYTLLTERPLDRESRAEYNITITV 423
Query: 444 TDSGGRSDTAMVQINIT----DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
TD G + + Q+N+T D N+ AP F YT V E+ + VSATD D G
Sbjct: 424 TDLG--TPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 500 INAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
NAQ+TYSL + IN G + + LD E + G+ V A D G P
Sbjct: 482 TNAQVTYSLLP--PQDPHLPLTSLVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSP 539
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLN 613
+LS V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 540 ALSSEALVRVVVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +
Sbjct: 600 AWLSYQL-LKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 674 HIKIED 679
H+ + D
Sbjct: 659 HVLLVD 664
Score = 202 bits (492), Expect = 2e-50
Identities = 148/466 (31%), Positives = 230/466 (49%), Gaps = 27/466 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGL- 422
F+ Q V+++E PPGT A D D ++N +Y I+ + + +GR
Sbjct: 134 FLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYP 193
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD ++E LT++A D G RS TA V I + D N+ AP FE Y +
Sbjct: 194 ELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQIS 253
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
ED+P+G V+ VSATD D G+N +I+YSL ++E + + F INP TG I K L
Sbjct: 254 EDSPVGFLVVKVSATDVDTGVNGEISYSLFQ--ASEEIG---KTFKINPLTGEIELKKQL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARD G + S V I V+DVND+ P +T+ I E+A T
Sbjct: 309 DFEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENA-PETV 365
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--VIRTNKALDRESVATHDLKA 657
V+ +D D G NG+I + +E+ F++ A + T + LDRES A +++
Sbjct: 366 VALFSVSDLDSGENGKISCSI----QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + I D+ND+ P F T ++ EN+ I + A D D G
Sbjct: 422 TVTDLGTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPP 773
NA V YS+ D + + +D L + LDYE+ + ++ + A+ SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEA-LQGFQFRVGASDHGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V ++V D NDN+P + + N C + P P Y
Sbjct: 541 LSSEALVRVVVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 199 bits (485), Expect = 1e-49
Identities = 172/593 (29%), Positives = 271/593 (45%), Gaps = 65/593 (10%)
Query: 4 PFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
PF Q ++ V+D NDHSPVF +Q V E + GTT A D D+G+N Y I
Sbjct: 114 PFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYII 173
Query: 63 ELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATD 121
+P V R DGR L+ +LDRE+ A + + A D
Sbjct: 174 --------SPN--------SYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALD 217
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
SP S TA +++ ++D NDN P+F + Y V + ED V ++ K+ ATD D
Sbjct: 218 GGSPPR---SGTAQVYIEVLDVNDNAPEFEQPFYRVQISEDSPV--GFLVVKVSATDVDT 272
Query: 182 GANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
G N I Y++ + ++ F I+ L+G++ L K LD+E+++SY + I A+D G+ S
Sbjct: 273 GVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGKC 332
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
T +LI + DVND+AP S F + EN P + D D G N +++ ++ +
Sbjct: 333 T--VLIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQE- 388
Query: 300 DYTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
DLP + + + T LDRE++A+Y + +T TD G P
Sbjct: 389 ------DLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 358 XXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN-----TRG 410
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV 468
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+ +P
Sbjct: 503 LVSINADNGH--LFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 469 ----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL--SSEISNEAVAHH 520
+N AP T V A G V V A D D G NA ++Y L ++E+ V H
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ G + T +LL + + L V +D G P S T + + +VD
Sbjct: 621 N---------GEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 142 bits (343), Expect = 2e-32
Identities = 135/497 (27%), Positives = 213/497 (42%), Gaps = 49/497 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND++P FE Y + E + G V+ + ATD D G N E+ Y++ + +
Sbjct: 231 IEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEE-- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F+I+ +G + + LD EK+ Y V ++A D +
Sbjct: 289 ---------------IGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT-----F 328
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S T+ + +ID ND+ P+ + +T + E+ T V+A +D D G N I +
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPET---VVALFSVSDLDSGENGKISCS 385
Query: 191 IIGGNTQMQFSIDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
I + F + S +L+ + LD E Y + I D G+P + + I
Sbjct: 386 I---QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTGNVDL 307
DVNDNAP F + + V EN I V A D D G NA++TY+ + +D +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++I+ +G ++ LD E +Q V A+D G P S+ A +
Sbjct: 503 LVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVL 562
Query: 368 -PGQY-EVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNG 419
P Q E P PG V + A D D L Y++ G F + + NG
Sbjct: 563 YPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNG 622
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITD--ANNYAPVFENAPYT 475
+ A+ L + ++ L V D+G RS TA + + + D + Y P+ E AP
Sbjct: 623 E--VRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPTQ 680
Query: 476 ASVFEDAPIGTTVLVVS 492
A A + T LVV+
Sbjct: 681 A----QADLLTVYLVVA 693
Score = 67.3 bits (157), Expect = 7e-10
Identities = 68/238 (28%), Positives = 101/238 (42%), Gaps = 15/238 (6%)
Query: 642 NKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENS 700
N+ LDRE + H V +++ DIND PVF + +SE+S
Sbjct: 88 NEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESS 147
Query: 701 PIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV--TMVDLDYES 758
P GTT A D D G N + +Y I + + G ELV +D + E+
Sbjct: 148 PPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEA 207
Query: 759 PRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYK--DCFPVG-PFGR 815
+ + SPP +V I V DVNDNAP +F+ F + + PVG +
Sbjct: 208 ELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAP---EFEQPFYRVQISEDSPVGFLVVK 264
Query: 816 VPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
V A D D V ++ Y + + +N TG + L QL + KL + EV++
Sbjct: 265 VSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQL--DFEKLQSYEVNI 320
>BC033068-1|AAH33068.1| 798|Homo sapiens protocadherin beta 13
protein.
Length = 798
Score = 222 bits (543), Expect = 1e-56
Identities = 183/606 (30%), Positives = 267/606 (44%), Gaps = 35/606 (5%)
Query: 91 RIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQF 150
+++ + LL LDRE + +T Q S A + V ID ND+ P F
Sbjct: 77 QLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQV--IDINDHSPVF 134
Query: 151 SEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG--- 207
+K V V E S A D DVG N+ Y II N+ + S
Sbjct: 135 LDKQMLVKVSE--SSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRVLTRKRSDGRK 191
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L K LD E+ RL + A DGGSP RS T Q+ I + DVNDNAP F ++
Sbjct: 192 YPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQ 251
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SE+ P+G+ +V+V A D D GVN E++Y++ + + I+P +G + QLD
Sbjct: 252 ISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQA--SEEIGKTFKINPLTGEIELKKQLD 309
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E Y++ + A D G S T + + E+ P T V
Sbjct: 310 FEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPE-TVV 366
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ +D D E+ ++ I F + S + +PLD + Y +T++
Sbjct: 367 ALFSVSDLDSGENGKISCSIQEDLP---FLLKSAENFYTLLTERPLDRESRAEYNITITV 423
Query: 444 TDSGGRSDTAMVQINIT----DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
TD G + + Q+N+T D N+ AP F YT V E+ + VSATD D G
Sbjct: 424 TDLG--TPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 500 INAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
NAQ+TYSL + IN G + + LD E + G+ V A D G P
Sbjct: 482 TNAQVTYSLLP--PQDPHLPLTSLVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSP 539
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLN 613
+LS V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 540 ALSSEALVRVVVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +
Sbjct: 600 AWLSYQL-LKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 674 HIKIED 679
H+ + D
Sbjct: 659 HVLLVD 664
Score = 202 bits (492), Expect = 2e-50
Identities = 148/466 (31%), Positives = 230/466 (49%), Gaps = 27/466 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGL- 422
F+ Q V+++E PPGT A D D ++N +Y I+ + + +GR
Sbjct: 134 FLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYP 193
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD ++E LT++A D G RS TA V I + D N+ AP FE Y +
Sbjct: 194 ELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQIS 253
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
ED+P+G V+ VSATD D G+N +I+YSL ++E + + F INP TG I K L
Sbjct: 254 EDSPVGFLVVKVSATDVDTGVNGEISYSLFQ--ASEEIG---KTFKINPLTGEIELKKQL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARD G + S V I V+DVND+ P +T+ I E+A T
Sbjct: 309 DFEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENA-PETV 365
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--VIRTNKALDRESVATHDLKA 657
V+ +D D G NG+I + +E+ F++ A + T + LDRES A +++
Sbjct: 366 VALFSVSDLDSGENGKISCSI----QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + I D+ND+ P F T ++ EN+ I + A D D G
Sbjct: 422 TVTDLGTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPP 773
NA V YS+ D + + +D L + LDYE+ + ++ + A+ SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEA-LQGFQFRVGASDHGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V ++V D NDN+P + + N C + P P Y
Sbjct: 541 LSSEALVRVVVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 199 bits (485), Expect = 1e-49
Identities = 172/593 (29%), Positives = 271/593 (45%), Gaps = 65/593 (10%)
Query: 4 PFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
PF Q ++ V+D NDHSPVF +Q V E + GTT A D D+G+N Y I
Sbjct: 114 PFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYII 173
Query: 63 ELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATD 121
+P V R DGR L+ +LDRE+ A + + A D
Sbjct: 174 --------SPN--------SYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALD 217
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
SP S TA +++ ++D NDN P+F + Y V + ED V ++ K+ ATD D
Sbjct: 218 GGSPPR---SGTAQVYIEVLDVNDNAPEFEQPFYRVQISEDSPV--GFLVVKVSATDVDT 272
Query: 182 GANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
G N I Y++ + ++ F I+ L+G++ L K LD+E+++SY + I A+D G+ S
Sbjct: 273 GVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGKC 332
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
T +LI + DVND+AP S F + EN P + D D G N +++ ++ +
Sbjct: 333 T--VLIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQE- 388
Query: 300 DYTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
DLP + + + T LDRE++A+Y + +T TD G P
Sbjct: 389 ------DLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 358 XXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN-----TRG 410
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV 468
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+ +P
Sbjct: 503 LVSINADNGH--LFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 469 ----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL--SSEISNEAVAHH 520
+N AP T V A G V V A D D G NA ++Y L ++E+ V H
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ G + T +LL + + L V +D G P S T + + +VD
Sbjct: 621 N---------GEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 142 bits (343), Expect = 2e-32
Identities = 135/497 (27%), Positives = 213/497 (42%), Gaps = 49/497 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND++P FE Y + E + G V+ + ATD D G N E+ Y++ + +
Sbjct: 231 IEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEE-- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F+I+ +G + + LD EK+ Y V ++A D +
Sbjct: 289 ---------------IGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT-----F 328
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S T+ + +ID ND+ P+ + +T + E+ T V+A +D D G N I +
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPET---VVALFSVSDLDSGENGKISCS 385
Query: 191 IIGGNTQMQFSIDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
I + F + S +L+ + LD E Y + I D G+P + + I
Sbjct: 386 I---QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTGNVDL 307
DVNDNAP F + + V EN I V A D D G NA++TY+ + +D +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++I+ +G ++ LD E +Q V A+D G P S+ A +
Sbjct: 503 LVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVL 562
Query: 368 -PGQY-EVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNG 419
P Q E P PG V + A D D L Y++ G F + + NG
Sbjct: 563 YPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNG 622
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITD--ANNYAPVFENAPYT 475
+ A+ L + ++ L V D+G RS TA + + + D + Y P+ E AP
Sbjct: 623 E--VRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPTQ 680
Query: 476 ASVFEDAPIGTTVLVVS 492
A A + T LVV+
Sbjct: 681 A----QADLLTVYLVVA 693
Score = 67.3 bits (157), Expect = 7e-10
Identities = 68/238 (28%), Positives = 101/238 (42%), Gaps = 15/238 (6%)
Query: 642 NKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENS 700
N+ LDRE + H V +++ DIND PVF + +SE+S
Sbjct: 88 NEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESS 147
Query: 701 PIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV--TMVDLDYES 758
P GTT A D D G N + +Y I + + G ELV +D + E+
Sbjct: 148 PPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEA 207
Query: 759 PRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYK--DCFPVG-PFGR 815
+ + SPP +V I V DVNDNAP +F+ F + + PVG +
Sbjct: 208 ELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAP---EFEQPFYRVQISEDSPVGFLVVK 264
Query: 816 VPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
V A D D V ++ Y + + +N TG + L QL + KL + EV++
Sbjct: 265 VSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQL--DFEKLQSYEVNI 320
>AY358427-1|AAQ88793.1| 798|Homo sapiens PCDHB13 protein.
Length = 798
Score = 222 bits (543), Expect = 1e-56
Identities = 183/606 (30%), Positives = 267/606 (44%), Gaps = 35/606 (5%)
Query: 91 RIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQF 150
+++ + LL LDRE + +T Q S A + V ID ND+ P F
Sbjct: 77 QLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQV--IDINDHSPVF 134
Query: 151 SEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG--- 207
+K V V E S A D DVG N+ Y II N+ + S
Sbjct: 135 LDKQMLVKVSE--SSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRVLTRKRSDGRK 191
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L K LD E+ RL + A DGGSP RS T Q+ I + DVNDNAP F ++
Sbjct: 192 YPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQ 251
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SE+ P+G+ +V+V A D D GVN E++Y++ + + I+P +G + QLD
Sbjct: 252 ISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQA--SEEIGKTFKINPLTGEIELKKQLD 309
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E Y++ + A D G S T + + E+ P T V
Sbjct: 310 FEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPE-TVV 366
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ +D D E+ ++ I F + S + +PLD + Y +T++
Sbjct: 367 ALFSVSDLDSGENGKISCSIQEDLP---FLLKSAENFYTLLTERPLDRESRAEYNITITV 423
Query: 444 TDSGGRSDTAMVQINIT----DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
TD G + + Q+N+T D N+ AP F YT V E+ + VSATD D G
Sbjct: 424 TDLG--TPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 500 INAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
NAQ+TYSL + IN G + + LD E + G+ V A D G P
Sbjct: 482 TNAQVTYSLLP--PQDPHLPLTSLVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSP 539
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLN 613
+LS V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 540 ALSSEALVRVVVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +
Sbjct: 600 AWLSYQL-LKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 674 HIKIED 679
H+ + D
Sbjct: 659 HVLLVD 664
Score = 202 bits (492), Expect = 2e-50
Identities = 148/466 (31%), Positives = 230/466 (49%), Gaps = 27/466 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGL- 422
F+ Q V+++E PPGT A D D ++N +Y I+ + + +GR
Sbjct: 134 FLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYP 193
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD ++E LT++A D G RS TA V I + D N+ AP FE Y +
Sbjct: 194 ELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQIS 253
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
ED+P+G V+ VSATD D G+N +I+YSL ++E + + F INP TG I K L
Sbjct: 254 EDSPVGFLVVKVSATDVDTGVNGEISYSLFQ--ASEEIG---KTFKINPLTGEIELKKQL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARD G + S V I V+DVND+ P +T+ I E+A T
Sbjct: 309 DFEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENA-PETV 365
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--VIRTNKALDRESVATHDLKA 657
V+ +D D G NG+I + +E+ F++ A + T + LDRES A +++
Sbjct: 366 VALFSVSDLDSGENGKISCSI----QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + I D+ND+ P F T ++ EN+ I + A D D G
Sbjct: 422 TVTDLGTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPP 773
NA V YS+ D + + +D L + LDYE+ + ++ + A+ SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEA-LQGFQFRVGASDHGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V ++V D NDN+P + + N C + P P Y
Sbjct: 541 LSSEALVRVVVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 199 bits (485), Expect = 1e-49
Identities = 172/593 (29%), Positives = 271/593 (45%), Gaps = 65/593 (10%)
Query: 4 PFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
PF Q ++ V+D NDHSPVF +Q V E + GTT A D D+G+N Y I
Sbjct: 114 PFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYII 173
Query: 63 ELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATD 121
+P V R DGR L+ +LDRE+ A + + A D
Sbjct: 174 --------SPN--------SYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALD 217
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
SP S TA +++ ++D NDN P+F + Y V + ED V ++ K+ ATD D
Sbjct: 218 GGSPPR---SGTAQVYIEVLDVNDNAPEFEQPFYRVQISEDSPV--GFLVVKVSATDVDT 272
Query: 182 GANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
G N I Y++ + ++ F I+ L+G++ L K LD+E+++SY + I A+D G+ S
Sbjct: 273 GVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGKC 332
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
T +LI + DVND+AP S F + EN P + D D G N +++ ++ +
Sbjct: 333 T--VLIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQE- 388
Query: 300 DYTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
DLP + + + T LDRE++A+Y + +T TD G P
Sbjct: 389 ------DLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 358 XXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN-----TRG 410
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV 468
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+ +P
Sbjct: 503 LVSINADNGH--LFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 469 ----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL--SSEISNEAVAHH 520
+N AP T V A G V V A D D G NA ++Y L ++E+ V H
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ G + T +LL + + L V +D G P S T + + +VD
Sbjct: 621 N---------GEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 142 bits (343), Expect = 2e-32
Identities = 135/497 (27%), Positives = 213/497 (42%), Gaps = 49/497 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND++P FE Y + E + G V+ + ATD D G N E+ Y++ + +
Sbjct: 231 IEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEE-- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F+I+ +G + + LD EK+ Y V ++A D +
Sbjct: 289 ---------------IGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT-----F 328
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S T+ + +ID ND+ P+ + +T + E+ T V+A +D D G N I +
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPET---VVALFSVSDLDSGENGKISCS 385
Query: 191 IIGGNTQMQFSIDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
I + F + S +L+ + LD E Y + I D G+P + + I
Sbjct: 386 I---QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTGNVDL 307
DVNDNAP F + + V EN I V A D D G NA++TY+ + +D +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++I+ +G ++ LD E +Q V A+D G P S+ A +
Sbjct: 503 LVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVL 562
Query: 368 -PGQY-EVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNG 419
P Q E P PG V + A D D L Y++ G F + + NG
Sbjct: 563 YPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNG 622
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITD--ANNYAPVFENAPYT 475
+ A+ L + ++ L V D+G RS TA + + + D + Y P+ E AP
Sbjct: 623 E--VRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPTQ 680
Query: 476 ASVFEDAPIGTTVLVVS 492
A A + T LVV+
Sbjct: 681 A----QADLLTVYLVVA 693
Score = 67.3 bits (157), Expect = 7e-10
Identities = 68/238 (28%), Positives = 101/238 (42%), Gaps = 15/238 (6%)
Query: 642 NKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENS 700
N+ LDRE + H V +++ DIND PVF + +SE+S
Sbjct: 88 NEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESS 147
Query: 701 PIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV--TMVDLDYES 758
P GTT A D D G N + +Y I + + G ELV +D + E+
Sbjct: 148 PPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEA 207
Query: 759 PRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYK--DCFPVG-PFGR 815
+ + SPP +V I V DVNDNAP +F+ F + + PVG +
Sbjct: 208 ELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAP---EFEQPFYRVQISEDSPVGFLVVK 264
Query: 816 VPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
V A D D V ++ Y + + +N TG + L QL + KL + EV++
Sbjct: 265 VSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQL--DFEKLQSYEVNI 320
>AF217745-1|AAK51613.1| 798|Homo sapiens protocadherin-beta13
protein.
Length = 798
Score = 222 bits (543), Expect = 1e-56
Identities = 183/606 (30%), Positives = 267/606 (44%), Gaps = 35/606 (5%)
Query: 91 RIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQF 150
+++ + LL LDRE + +T Q S A + V ID ND+ P F
Sbjct: 77 QLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQV--IDINDHSPVF 134
Query: 151 SEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG--- 207
+K V V E S A D DVG N+ Y II N+ + S
Sbjct: 135 LDKQMLVKVSE--SSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRVLTRKRSDGRK 191
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L K LD E+ RL + A DGGSP RS T Q+ I + DVNDNAP F ++
Sbjct: 192 YPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQ 251
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SE+ P+G+ +V+V A D D GVN E++Y++ + + I+P +G + QLD
Sbjct: 252 ISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQA--SEEIGKTFKINPLTGEIELKKQLD 309
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E Y++ + A D G S T + + E+ P T V
Sbjct: 310 FEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPE-TVV 366
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ +D D E+ ++ I F + S + +PLD + Y +T++
Sbjct: 367 ALFSVSDLDSGENGKISCSIQEDLP---FLLKSAENFYTLLTERPLDRESRAEYNITITV 423
Query: 444 TDSGGRSDTAMVQINIT----DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
TD G + + Q+N+T D N+ AP F YT V E+ + VSATD D G
Sbjct: 424 TDLG--TPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 500 INAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
NAQ+TYSL + IN G + + LD E + G+ V A D G P
Sbjct: 482 TNAQVTYSLLP--PQDPHLPLTSLVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSP 539
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLN 613
+LS V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 540 ALSSEALVRVVVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +
Sbjct: 600 AWLSYQL-LKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 674 HIKIED 679
H+ + D
Sbjct: 659 HVLLVD 664
Score = 202 bits (492), Expect = 2e-50
Identities = 148/466 (31%), Positives = 230/466 (49%), Gaps = 27/466 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGL- 422
F+ Q V+++E PPGT A D D ++N +Y I+ + + +GR
Sbjct: 134 FLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYP 193
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD ++E LT++A D G RS TA V I + D N+ AP FE Y +
Sbjct: 194 ELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQIS 253
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
ED+P+G V+ VSATD D G+N +I+YSL ++E + + F INP TG I K L
Sbjct: 254 EDSPVGFLVVKVSATDVDTGVNGEISYSLFQ--ASEEIG---KTFKINPLTGEIELKKQL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARD G + S V I V+DVND+ P +T+ I E+A T
Sbjct: 309 DFEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENA-PETV 365
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--VIRTNKALDRESVATHDLKA 657
V+ +D D G NG+I + +E+ F++ A + T + LDRES A +++
Sbjct: 366 VALFSVSDLDSGENGKISCSI----QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + I D+ND+ P F T ++ EN+ I + A D D G
Sbjct: 422 TVTDLGTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPP 773
NA V YS+ D + + +D L + LDYE+ + ++ + A+ SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEA-LQGFQFRVGASDHGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V ++V D NDN+P + + N C + P P Y
Sbjct: 541 LSSEALVRVVVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 199 bits (485), Expect = 1e-49
Identities = 172/593 (29%), Positives = 271/593 (45%), Gaps = 65/593 (10%)
Query: 4 PFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
PF Q ++ V+D NDHSPVF +Q V E + GTT A D D+G+N Y I
Sbjct: 114 PFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYII 173
Query: 63 ELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATD 121
+P V R DGR L+ +LDRE+ A + + A D
Sbjct: 174 --------SPN--------SYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALD 217
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
SP S TA +++ ++D NDN P+F + Y V + ED V ++ K+ ATD D
Sbjct: 218 GGSPPR---SGTAQVYIEVLDVNDNAPEFEQPFYRVQISEDSPV--GFLVVKVSATDVDT 272
Query: 182 GANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
G N I Y++ + ++ F I+ L+G++ L K LD+E+++SY + I A+D G+ S
Sbjct: 273 GVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGKC 332
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
T +LI + DVND+AP S F + EN P + D D G N +++ ++ +
Sbjct: 333 T--VLIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQE- 388
Query: 300 DYTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
DLP + + + T LDRE++A+Y + +T TD G P
Sbjct: 389 ------DLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 358 XXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN-----TRG 410
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV 468
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+ +P
Sbjct: 503 LVSINADNGH--LFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 469 ----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL--SSEISNEAVAHH 520
+N AP T V A G V V A D D G NA ++Y L ++E+ V H
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ G + T +LL + + L V +D G P S T + + +VD
Sbjct: 621 N---------GEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 142 bits (343), Expect = 2e-32
Identities = 135/497 (27%), Positives = 213/497 (42%), Gaps = 49/497 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND++P FE Y + E + G V+ + ATD D G N E+ Y++ + +
Sbjct: 231 IEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEE-- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F+I+ +G + + LD EK+ Y V ++A D +
Sbjct: 289 ---------------IGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT-----F 328
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S T+ + +ID ND+ P+ + +T + E+ T V+A +D D G N I +
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPET---VVALFSVSDLDSGENGKISCS 385
Query: 191 IIGGNTQMQFSIDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
I + F + S +L+ + LD E Y + I D G+P + + I
Sbjct: 386 I---QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTGNVDL 307
DVNDNAP F + + V EN I V A D D G NA++TY+ + +D +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++I+ +G ++ LD E +Q V A+D G P S+ A +
Sbjct: 503 LVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVL 562
Query: 368 -PGQY-EVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNG 419
P Q E P PG V + A D D L Y++ G F + + NG
Sbjct: 563 YPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNG 622
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITD--ANNYAPVFENAPYT 475
+ A+ L + ++ L V D+G RS TA + + + D + Y P+ E AP
Sbjct: 623 E--VRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPTQ 680
Query: 476 ASVFEDAPIGTTVLVVS 492
A A + T LVV+
Sbjct: 681 A----QADLLTVYLVVA 693
Score = 67.3 bits (157), Expect = 7e-10
Identities = 68/238 (28%), Positives = 101/238 (42%), Gaps = 15/238 (6%)
Query: 642 NKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENS 700
N+ LDRE + H V +++ DIND PVF + +SE+S
Sbjct: 88 NEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESS 147
Query: 701 PIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV--TMVDLDYES 758
P GTT A D D G N + +Y I + + G ELV +D + E+
Sbjct: 148 PPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEA 207
Query: 759 PRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYK--DCFPVG-PFGR 815
+ + SPP +V I V DVNDNAP +F+ F + + PVG +
Sbjct: 208 ELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAP---EFEQPFYRVQISEDSPVGFLVVK 264
Query: 816 VPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
V A D D V ++ Y + + +N TG + L QL + KL + EV++
Sbjct: 265 VSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQL--DFEKLQSYEVNI 320
>AF152505-1|AAD43766.1| 837|Homo sapiens protocadherin gamma A11
short form protein protein.
Length = 837
Score = 222 bits (543), Expect = 1e-56
Identities = 183/606 (30%), Positives = 274/606 (45%), Gaps = 28/606 (4%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ TV + V D L + V IID NDN P
Sbjct: 75 LFAVNPRSGSLITAGRIDREELCE-TVSSCFLNMELLVEDTLKIYG-VEVEIIDINDNAP 132
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDSL 205
F E + V E A A D DVG NS Y + N Q++ D
Sbjct: 133 SFQEDEVEIKVSEH--AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGA 190
Query: 206 SG-DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++ L +LD E+ ++ L++ A DGG P R + + + DVND+ P F S+++
Sbjct: 191 KNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRV 250
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
SV EN+ G ++ V A D DEG+N E+ Y+ ++ +D ++G V G L
Sbjct: 251 SVPENISSGTRVLMVNATDPDEGINGEVMYSF--RNMESKASEIFQLDSQTGEVQVRGSL 308
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ + DGG T T + E+ PPGT
Sbjct: 309 DFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTV 366
Query: 385 VVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ L D D +N + + T N LIT ++ LD + + Y +T++A
Sbjct: 367 IALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLIT-SRVLDRELVQSYNITLTA 425
Query: 444 TDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G S V +N+ D N+ PVF ++ Y+A + E+ P G ++ V+A D D N
Sbjct: 426 TDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQN 485
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
A +TYSL+ + IN TG + + D E L V ARD G P L
Sbjct: 486 ALVTYSLTDDTVQGVPL--SSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPL 543
Query: 562 SDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLNG 614
S + + V+D NDN P + L T A G V++V A D D G N
Sbjct: 544 SSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNA 603
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSSTVIV 673
+ Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+TV +
Sbjct: 604 WLSYRL-LKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSATVTL 661
Query: 674 HIKIED 679
+ + D
Sbjct: 662 TVAVAD 667
Score = 207 bits (505), Expect = 5e-52
Identities = 176/585 (30%), Positives = 262/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND++P F+ + E V E A G A D D+G N+ Y
Sbjct: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSY--------Q 172
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L+P + +Q R DG ++ L+ SLDREK A + +L+ A D P+
Sbjct: 173 LSPNN--------YFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIR- 223
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
I V ++D ND+ P F++ Y VSV E+IS + + ATD D G N +
Sbjct: 224 --KGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENIS--SGTRVLMVNATDPDEGINGEVM 279
Query: 189 YAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ ++ F +DS +G+V + +LD+E+ R Y + I+ QDGG TT +LI
Sbjct: 280 YSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGG--GLFTTTTMLIT 337
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDNAP + S+ EN P G I + D D G N +++ + +
Sbjct: 338 VVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPN-------H 390
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ G Y TS LDRE Y + +TATD G PP SA
Sbjct: 391 LPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNP 450
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRG---RFSITSQN 418
F Y + E+ P G + ++TA D D + N L Y +T +G ++ +
Sbjct: 451 PVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINS 510
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ Q D++Q R L V A DSG S + + + D N+ AP ++ P
Sbjct: 511 NTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPT 570
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 571 DGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLK-------ASEPGLFAVGEH 623
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 624 TGEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 667
Score = 188 bits (458), Expect = 3e-46
Identities = 156/545 (28%), Positives = 253/545 (46%), Gaps = 41/545 (7%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGN-----TRGRFSITSQN 418
F + E++++E PG A D D N L Y+++ N RGR T
Sbjct: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGR---TDGA 190
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
+ + LD ++E ++L ++A D G R +++ + D N++ P+F + Y
Sbjct: 191 KNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRV 250
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+ GT VL+V+ATD D GIN ++ YS + S + + F ++ QTG +
Sbjct: 251 SVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKAS-----EIFQLDSQTGEVQVR 305
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LD E Y + + +DGG L TT + I+VVDVNDN P +I+E++
Sbjct: 306 GSLDFEKYRFYEMEIQGQDGG--GLFTTTTMLITVVDVNDNAPEITITSSINSILENSPP 363
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATH 653
GT ++ + D D G NG++ + F ++ G + T++ LDRE V ++
Sbjct: 364 GTVIALLNVQDQDSGENGQVSCFIP----NHLPFKLEKTYGNYYKLITSRVLDRELVQSY 419
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
++ A D G+PP S+ V + + D ND+PPVF + YI EN+P G +I + A D
Sbjct: 420 NITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALD 479
Query: 714 PDEGPNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AA 770
PD NA+V YS+ S S+ L + DYE R + ++ R +
Sbjct: 480 PDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSG 539
Query: 771 SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------D 820
PPL ++V + + V D NDNAP + + + + + P P Y D
Sbjct: 540 DPPLSSNVSLSLFVLDQNDNAPEIL-YPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKD 598
Query: 821 ADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAM 879
+ L YR+L + L + E TG + + L ++ V+V D G + A
Sbjct: 599 SGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 658
Query: 880 MQLSV 884
+ L+V
Sbjct: 659 VTLTV 663
Score = 167 bits (406), Expect = 5e-40
Identities = 140/473 (29%), Positives = 209/473 (44%), Gaps = 44/473 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD NDH P+F Y SV E SSGT VL + ATD D G N EV Y+
Sbjct: 230 RVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFR------ 283
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N E ++F++D ++G + R SLD EK Y + ++ D
Sbjct: 284 -NMESKAS----------EIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG----- 327
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD-NPVIAKIKATDADVGANSAIR 188
L +T T+ + ++D NDN P+ T T S++ + + VIA + D D G N +
Sbjct: 328 LFTTTTMLITVVDVNDNAPEI---TITSSINSILENSPPGTVIALLNVQDQDSGENGQVS 384
Query: 189 YAIIGGNTQMQFSIDSLSGDV-SLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
I + F ++ G+ L+ + LD E V+SY + + A D GSP S T + +
Sbjct: 385 CFI---PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWL 441
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-N 304
N+ D NDN P F S + + EN P G SI V A D D NA +TY++TD G
Sbjct: 442 NVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVP 501
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ ++I+ +G +Y D E +L V A D GDPP S+ +
Sbjct: 502 LSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAP 561
Query: 365 XFM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSIT 415
+ G VELA PG V + A D D L Y + + G F++
Sbjct: 562 EILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVG 621
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A++ V
Sbjct: 622 EHTGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEV 672
Score = 122 bits (293), Expect = 2e-26
Identities = 89/281 (31%), Positives = 132/281 (46%), Gaps = 18/281 (6%)
Query: 522 QQFVINPQTGAITTNKLLDR----ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDN 577
Q F +NP++G++ T +DR ET+S L + V VE+ ++D+NDN
Sbjct: 74 QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELL---VEDTLKIYGVEVEIIDINDN 130
Query: 578 EPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSF--VIDPA 635
P F++ + E A+ G + A D DVG+N Y+L P + D A
Sbjct: 131 APSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGA 190
Query: 636 SG-VIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+ +LDRE A H L A+DGG P + V + + + D+ND P+F
Sbjct: 191 KNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRV 250
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMV 752
+ EN GT + + A DPDEG N V YS + + S F L+++ G E+
Sbjct: 251 SVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG----EVQVRG 306
Query: 753 DLDYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
LD+E R YE+ I+ L+ + I V DVNDNAP
Sbjct: 307 SLDFEKYR-FYEMEIQGQDGGGLFTTTTMLITVVDVNDNAP 346
Score = 81.4 bits (192), Expect = 4e-14
Identities = 63/247 (25%), Positives = 102/247 (41%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H +NV D ND+ PVF Y A + E G ++ ++ A D D +NA V Y++ T
Sbjct: 438 HVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSL---TD 494
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
DT+ + I+ +G L S D E+ + V A D P
Sbjct: 495 DTVQ-----------GVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDP-- 541
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDI-----SVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN P+ + S ++ K+ A D D G
Sbjct: 542 -PLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ + F++ +G+V + L LV+ QD G P S T
Sbjct: 601 QNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT 660
Query: 243 LLINIRD 249
L + + D
Sbjct: 661 LTVAVAD 667
Score = 64.5 bits (150), Expect = 5e-09
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 18/286 (6%)
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGS---FVIDPASGVIRTNKALDRESVATHDLKA 657
S VG D+GL R + + G F ++P SG + T +DRE + + +
Sbjct: 44 SFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELC-ETVSS 102
Query: 658 VAIDGGTPPQSSTVIVHIKIE--DINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
++ + + I +++E DIND+ P F+ D + +SE++ G A DPD
Sbjct: 103 CFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPD 162
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETR---QGSDKAELVTMVDLDYESPRKKYELV--IRAA 770
G N++ Y + +N FSL+ R G+ ELV LD E L+ +
Sbjct: 163 VGVNSLQSYQL---SPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGG 219
Query: 771 SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQ 828
P V + ++V DVND+ P+ + ++ V A D D + ++
Sbjct: 220 DPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVM 279
Query: 829 Y--RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
Y R + + + L+ TG + + L+ + ME+ DG
Sbjct: 280 YSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDG 325
>AF152502-1|AAD43763.2| 797|Homo sapiens protocadherin beta 9
protein.
Length = 797
Score = 222 bits (543), Expect = 1e-56
Identities = 180/601 (29%), Positives = 264/601 (43%), Gaps = 26/601 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 77 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVRDINDHSPVFR 134
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS-----LS 206
K + + E+ + + +A D D G NS Y I N+ I +
Sbjct: 135 HKEMVLKISENTA--EGTAFRLERAQDPDEGHNSIQNYTI-SSNSFFHIKISGSDEGMIY 191
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD E+ L + A DGGSPSRS T+ + I + DVNDNAP+F +L++
Sbjct: 192 PELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYETQA 251
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDR 326
EN P+G IV+V A DAD GVNAE++Y+ D + ++ I+P SG ++ LD
Sbjct: 252 PENSPVGSLIVKVSAGDADSGVNAEVSYSFFDA--SEDILTTFQINPFSGEIFLRELLDY 309
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
E Y++ + A DGG SA T + +AE+ PG +
Sbjct: 310 ELVNSYKINIQAMDGGG--LSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLA 366
Query: 387 TLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
D D + F S + ++ LD + + Y +T++ TD
Sbjct: 367 VFKIKDRDSGENGKTICYVQDNLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDL 426
Query: 447 G-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G R T + + ++D N+ AP F YT V E+ + VSATD D G NAQ+
Sbjct: 427 GTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQV 486
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
TYSL + IN G + + LD E + + V A D G P+LS
Sbjct: 487 TYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFDFRVGASDRGSPALSSE 544
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGRIHY 618
V + V+D NDN P L + LV G V++V A D D G N + Y
Sbjct: 545 ALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSY 604
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
+L K E G F + +G +RT + L A H L + D G PP+S+T +H+ +
Sbjct: 605 QL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLV 663
Query: 679 D 679
D
Sbjct: 664 D 664
Score = 194 bits (472), Expect = 5e-48
Identities = 171/594 (28%), Positives = 261/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDHSPVF ++ + E + GT +A D D G N+
Sbjct: 110 MDDPFQIYRAELRVRDINDHSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQN 169
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + D I L+ +LDRE+ ++ + A
Sbjct: 170 YTI------------SSNSFFHIKISGSDEGMI---YPELVLDKALDREEQEELSLTLTA 214
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+TI + ++D NDN PQF++ Y E+ V +I K+ A DA
Sbjct: 215 LDGGSP---SRSGTSTIRIVVLDVNDNAPQFAQALYETQAPENSPV--GSLIVKVSAGDA 269
Query: 180 DVGANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ + + F I+ SG++ L + LDYE V SY++ I+A DGG S
Sbjct: 270 DSGVNAEVSYSFFDASEDILTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGGGLSA 329
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
T +LI + D NDN P S SV+EN P G + + D D G N + +
Sbjct: 330 RCT--VLIKVLDSNDNPPELIISSLSNSVAENSP-GIVLAVFKIKDRDSGENGKTICYVQ 386
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
D +LP + P Y T G LDRE++A+Y + +T TD G P +
Sbjct: 387 D-------NLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDLGTPRLKTEHSITL 439
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 440 QVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 499
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+
Sbjct: 500 LASLVSINADNGH--LFALRSLDYEALQAFDFRVGASDRGSPALSSEALVRVLVLDANDN 557
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 558 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 610
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 174 bits (423), Expect = 4e-42
Identities = 136/462 (29%), Positives = 223/462 (48%), Gaps = 32/462 (6%)
Query: 373 VELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI----TVAQ 427
++++E+ GT A D DE N + N+ I+ + G+I + +
Sbjct: 140 LKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIKISGSD-EGMIYPELVLDK 198
Query: 428 PLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD +++ LT++A D G RS T+ ++I + D N+ AP F A Y E++P+G
Sbjct: 199 ALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYETQAPENSPVG 258
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
+ ++ VSA D+D G+NA+++YS + S + + F INP +G I +LLD E ++
Sbjct: 259 SLIVKVSAGDADSGVNAEVSYSFF-DASEDILT----TFQINPFSGEIFLRELLDYELVN 313
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
Y + + A DGG LS V I V+D NDN P + ++ E++ G ++
Sbjct: 314 SYKINIQAMDGG--GLSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLAVFKI 370
Query: 606 TDADVGLNGR-IHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKAVAID 661
D D G NG+ I Y D F + P+ ++ T ALDRES A +++ D
Sbjct: 371 KDRDSGENGKTICYVQDNLP-----FFLKPSVDNFYILMTEGALDRESKAEYNITITVTD 425
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAV 721
GTP + + +++ D+ND+ P F T ++ EN+ IG + A D D G NA
Sbjct: 426 LGTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQ 485
Query: 722 VHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V YS+ D + + +D L + LDYE+ + ++ + A+ SP L ++
Sbjct: 486 VTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFDFRVGASDRGSPALSSE 544
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
V +LV D NDN+P + + N C + P P Y
Sbjct: 545 ALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 97.5 bits (232), Expect = 6e-19
Identities = 85/279 (30%), Positives = 122/279 (43%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 73 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVRDINDHS 130
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D G N +Y + + G+
Sbjct: 131 PVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIK-ISGSDEGM 189
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T + I + D+ND+ P F
Sbjct: 190 IYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQALYET 249
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSP+G+ I ++ A D D G NA V YS D S + E+ L
Sbjct: 250 QAPENSPVGSLIVKVSAGDADSGVNAEVSYSF--FDASEDILTTFQINPFSGEIFLRELL 307
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L V I V D NDN P
Sbjct: 308 DYELV-NSYKINIQAMDGGGLSARCTVLIKVLDSNDNPP 345
Score = 74.5 bits (175), Expect = 5e-12
Identities = 73/261 (27%), Positives = 112/261 (42%), Gaps = 17/261 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 69 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDIND 128
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF + ISEN+ GT RA DPDEG N++ +Y+I SNSF G
Sbjct: 129 HSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTI----SSNSFFHIKISG 184
Query: 743 SDKAELVTMVDLDYESPRKKYE---LVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKD 796
SD+ + + LD R++ E L + A SP + I+V DVNDNAP
Sbjct: 185 SDEGMIYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAPQFAQ 244
Query: 797 FQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNANL--ILLNETTGSMTL 851
+ + PVG +V A DAD V ++ Y + L +N +G + L
Sbjct: 245 -ALYETQAPENSPVGSLIVKVSAGDADSGVNAEVSYSFFDASEDILTTFQINPFSGEIFL 303
Query: 852 SPQLNTNVPKLATMEVSVTDG 872
L+ + + + DG
Sbjct: 304 RELLDYELVNSYKINIQAMDG 324
>AF152492-1|AAD43753.1| 798|Homo sapiens protocadherin beta 13
protein.
Length = 798
Score = 222 bits (543), Expect = 1e-56
Identities = 183/606 (30%), Positives = 267/606 (44%), Gaps = 35/606 (5%)
Query: 91 RIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQF 150
+++ + LL LDRE + +T Q S A + V ID ND+ P F
Sbjct: 77 QLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQV--IDINDHSPVF 134
Query: 151 SEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG--- 207
+K V V E S A D DVG N+ Y II N+ + S
Sbjct: 135 LDKQMLVKVSE--SSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRVLTRKRSDGRK 191
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L K LD E+ RL + A DGGSP RS T Q+ I + DVNDNAP F ++
Sbjct: 192 YPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQ 251
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
+SE+ P+G+ +V+V A D D GVN E++Y++ + + I+P +G + QLD
Sbjct: 252 ISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQA--SEEIGKTFKINPLTGEIELKKQLD 309
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
E Y++ + A D G S T + + E+ P T V
Sbjct: 310 FEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPE-TVV 366
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ +D D E+ ++ I F + S + +PLD + Y +T++
Sbjct: 367 ALFSVSDLDSGENGKISCSIQEDLP---FLLKSAENFYTLLTERPLDRESRAEYNITITV 423
Query: 444 TDSGGRSDTAMVQINIT----DANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
TD G + + Q+N+T D N+ AP F YT V E+ + VSATD D G
Sbjct: 424 TDLG--TPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 500 INAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVP 559
NAQ+TYSL + IN G + + LD E + G+ V A D G P
Sbjct: 482 TNAQVTYSLLP--PQDPHLPLTSLVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSP 539
Query: 560 SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLN 613
+LS V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 540 ALSSEALVRVVVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 614 GRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIV 673
+ Y+L K E G F + +G +RT + L A H L + D G PP+S+T +
Sbjct: 600 AWLSYQL-LKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 674 HIKIED 679
H+ + D
Sbjct: 659 HVLLVD 664
Score = 202 bits (492), Expect = 2e-50
Identities = 148/466 (31%), Positives = 230/466 (49%), Gaps = 27/466 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGL- 422
F+ Q V+++E PPGT A D D ++N +Y I+ + + +GR
Sbjct: 134 FLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYP 193
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + + LD ++E LT++A D G RS TA V I + D N+ AP FE Y +
Sbjct: 194 ELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQIS 253
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
ED+P+G V+ VSATD D G+N +I+YSL ++E + + F INP TG I K L
Sbjct: 254 EDSPVGFLVVKVSATDVDTGVNGEISYSLFQ--ASEEIG---KTFKINPLTGEIELKKQL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + + ARD G + S V I V+DVND+ P +T+ I E+A T
Sbjct: 309 DFEKLQSYEVNIEARDAG--TFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENA-PETV 365
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG--VIRTNKALDRESVATHDLKA 657
V+ +D D G NG+I + +E+ F++ A + T + LDRES A +++
Sbjct: 366 VALFSVSDLDSGENGKISCSI----QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITI 421
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
D GTP + + + + I D+ND+ P F T ++ EN+ I + A D D G
Sbjct: 422 TVTDLGTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481
Query: 718 PNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPP 773
NA V YS+ D + + +D L + LDYE+ + ++ + A+ SP
Sbjct: 482 TNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEA-LQGFQFRVGASDHGSPA 540
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V ++V D NDN+P + + N C + P P Y
Sbjct: 541 LSSEALVRVVVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 199 bits (485), Expect = 1e-49
Identities = 172/593 (29%), Positives = 271/593 (45%), Gaps = 65/593 (10%)
Query: 4 PFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTI 62
PF Q ++ V+D NDHSPVF +Q V E + GTT A D D+G+N Y I
Sbjct: 114 PFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYII 173
Query: 63 ELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATD 121
+P V R DGR L+ +LDRE+ A + + A D
Sbjct: 174 --------SPN--------SYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALD 217
Query: 122 QASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADV 181
SP S TA +++ ++D NDN P+F + Y V + ED V ++ K+ ATD D
Sbjct: 218 GGSPPR---SGTAQVYIEVLDVNDNAPEFEQPFYRVQISEDSPV--GFLVVKVSATDVDT 272
Query: 182 GANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSN 239
G N I Y++ + ++ F I+ L+G++ L K LD+E+++SY + I A+D G+ S
Sbjct: 273 GVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGKC 332
Query: 240 TTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDK 299
T +LI + DVND+AP S F + EN P + D D G N +++ ++ +
Sbjct: 333 T--VLIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQE- 388
Query: 300 DYTGNVDLPITIDPRSGW--VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
DLP + + + T LDRE++A+Y + +T TD G P
Sbjct: 389 ------DLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 358 XXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN-----TRG 410
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 411 RFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV 468
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+ +P
Sbjct: 503 LVSINADNGH--LFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 469 ----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSL--SSEISNEAVAHH 520
+N AP T V A G V V A D D G NA ++Y L ++E+ V H
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
+ G + T +LL + + L V +D G P S T + + +VD
Sbjct: 621 N---------GEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 142 bits (343), Expect = 2e-32
Identities = 135/497 (27%), Positives = 213/497 (42%), Gaps = 49/497 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND++P FE Y + E + G V+ + ATD D G N E+ Y++ + +
Sbjct: 231 IEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEE-- 288
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ F+I+ +G + + LD EK+ Y V ++A D +
Sbjct: 289 ---------------IGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT-----F 328
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S T+ + +ID ND+ P+ + +T + E+ T V+A +D D G N I +
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPET---VVALFSVSDLDSGENGKISCS 385
Query: 191 IIGGNTQMQFSIDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIR 248
I + F + S +L+ + LD E Y + I D G+P + + I
Sbjct: 386 I---QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIA 442
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTGNVDL 307
DVNDNAP F + + V EN I V A D D G NA++TY+ + +D +
Sbjct: 443 DVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTS 502
Query: 308 PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
++I+ +G ++ LD E +Q V A+D G P S+ A +
Sbjct: 503 LVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVL 562
Query: 368 -PGQY-EVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQNG 419
P Q E P PG V + A D D L Y++ G F + + NG
Sbjct: 563 YPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNG 622
Query: 420 RGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITD--ANNYAPVFENAPYT 475
+ A+ L + ++ L V D+G RS TA + + + D + Y P+ E AP
Sbjct: 623 E--VRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPTQ 680
Query: 476 ASVFEDAPIGTTVLVVS 492
A A + T LVV+
Sbjct: 681 A----QADLLTVYLVVA 693
Score = 67.3 bits (157), Expect = 7e-10
Identities = 68/238 (28%), Positives = 101/238 (42%), Gaps = 15/238 (6%)
Query: 642 NKALDRESVATHDLKAVA-IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENS 700
N+ LDRE + H V +++ DIND PVF + +SE+S
Sbjct: 88 NEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESS 147
Query: 701 PIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELV--TMVDLDYES 758
P GTT A D D G N + +Y I + + G ELV +D + E+
Sbjct: 148 PPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEA 207
Query: 759 PRKKYELVIRAASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYK--DCFPVG-PFGR 815
+ + SPP +V I V DVNDNAP +F+ F + + PVG +
Sbjct: 208 ELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAP---EFEQPFYRVQISEDSPVGFLVVK 264
Query: 816 VPAYDAD--VTDKLQYRILSGNN--ANLILLNETTGSMTLSPQLNTNVPKLATMEVSV 869
V A D D V ++ Y + + +N TG + L QL + KL + EV++
Sbjct: 265 VSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQL--DFEKLQSYEVNI 320
>AF152320-1|AAD43714.1| 935|Homo sapiens protocadherin gamma A11
protein.
Length = 935
Score = 222 bits (543), Expect = 1e-56
Identities = 183/606 (30%), Positives = 274/606 (45%), Gaps = 28/606 (4%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ TV + V D L + V IID NDN P
Sbjct: 75 LFAVNPRSGSLITAGRIDREELCE-TVSSCFLNMELLVEDTLKIYG-VEVEIIDINDNAP 132
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGN---TQMQFSIDSL 205
F E + V E A A D DVG NS Y + N Q++ D
Sbjct: 133 SFQEDEVEIKVSEH--AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGA 190
Query: 206 SG-DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQE 264
++ L +LD E+ ++ L++ A DGG P R + + + DVND+ P F S+++
Sbjct: 191 KNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRV 250
Query: 265 SVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQL 324
SV EN+ G ++ V A D DEG+N E+ Y+ ++ +D ++G V G L
Sbjct: 251 SVPENISSGTRVLMVNATDPDEGINGEVMYSF--RNMESKASEIFQLDSQTGEVQVRGSL 308
Query: 325 DRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
D E Y++ + DGG T T + E+ PPGT
Sbjct: 309 DFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTV 366
Query: 385 VVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
+ L D D +N + + T N LIT ++ LD + + Y +T++A
Sbjct: 367 IALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLIT-SRVLDRELVQSYNITLTA 425
Query: 444 TDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G S V +N+ D N+ PVF ++ Y+A + E+ P G ++ V+A D D N
Sbjct: 426 TDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQN 485
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
A +TYSL+ + IN TG + + D E L V ARD G P L
Sbjct: 486 ALVTYSLTDDTVQGVPL--SSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPL 543
Query: 562 SDTTDVEISVVDVNDNEP-VFKQQLYTAN------IMEDALVGTSVSQVGATDADVGLNG 614
S + + V+D NDN P + L T A G V++V A D D G N
Sbjct: 544 SSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNA 603
Query: 615 RIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSSTVIV 673
+ Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+TV +
Sbjct: 604 WLSYRL-LKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSATVTL 661
Query: 674 HIKIED 679
+ + D
Sbjct: 662 TVAVAD 667
Score = 207 bits (505), Expect = 5e-52
Identities = 176/585 (30%), Positives = 262/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND++P F+ + E V E A G A D D+G N+ Y
Sbjct: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSY--------Q 172
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L+P + +Q R DG ++ L+ SLDREK A + +L+ A D P+
Sbjct: 173 LSPNN--------YFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIR- 223
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
I V ++D ND+ P F++ Y VSV E+IS + + ATD D G N +
Sbjct: 224 --KGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENIS--SGTRVLMVNATDPDEGINGEVM 279
Query: 189 YAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ ++ F +DS +G+V + +LD+E+ R Y + I+ QDGG TT +LI
Sbjct: 280 YSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGG--GLFTTTTMLIT 337
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDNAP + S+ EN P G I + D D G N +++ + +
Sbjct: 338 VVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPN-------H 390
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ G Y TS LDRE Y + +TATD G PP SA
Sbjct: 391 LPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNP 450
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEITGGNTRG---RFSITSQN 418
F Y + E+ P G + ++TA D D + N L Y +T +G ++ +
Sbjct: 451 PVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINS 510
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ Q D++Q R L V A DSG S + + + D N+ AP ++ P
Sbjct: 511 NTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPT 570
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++Y L A F +
Sbjct: 571 DGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLK-------ASEPGLFAVGEH 623
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 624 TGEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 667
Score = 188 bits (458), Expect = 3e-46
Identities = 156/545 (28%), Positives = 253/545 (46%), Gaps = 41/545 (7%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGN-----TRGRFSITSQN 418
F + E++++E PG A D D N L Y+++ N RGR T
Sbjct: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGR---TDGA 190
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
+ + LD ++E ++L ++A D G R +++ + D N++ P+F + Y
Sbjct: 191 KNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRV 250
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV E+ GT VL+V+ATD D GIN ++ YS + S + + F ++ QTG +
Sbjct: 251 SVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKAS-----EIFQLDSQTGEVQVR 305
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
LD E Y + + +DGG L TT + I+VVDVNDN P +I+E++
Sbjct: 306 GSLDFEKYRFYEMEIQGQDGG--GLFTTTTMLITVVDVNDNAPEITITSSINSILENSPP 363
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATH 653
GT ++ + D D G NG++ + F ++ G + T++ LDRE V ++
Sbjct: 364 GTVIALLNVQDQDSGENGQVSCFIP----NHLPFKLEKTYGNYYKLITSRVLDRELVQSY 419
Query: 654 DLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHD 713
++ A D G+PP S+ V + + D ND+PPVF + YI EN+P G +I + A D
Sbjct: 420 NITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALD 479
Query: 714 PDEGPNAVVHYSIKGGD-DSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AA 770
PD NA+V YS+ S S+ L + DYE R + ++ R +
Sbjct: 480 PDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSG 539
Query: 771 SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------D 820
PPL ++V + + V D NDNAP + + + + + P P Y D
Sbjct: 540 DPPLSSNVSLSLFVLDQNDNAPEIL-YPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKD 598
Query: 821 ADVTDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAM 879
+ L YR+L + L + E TG + + L ++ V+V D G + A
Sbjct: 599 SGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 658
Query: 880 MQLSV 884
+ L+V
Sbjct: 659 VTLTV 663
Score = 167 bits (406), Expect = 5e-40
Identities = 140/473 (29%), Positives = 209/473 (44%), Gaps = 44/473 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ VLD NDH P+F Y SV E SSGT VL + ATD D G N EV Y+
Sbjct: 230 RVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFR------ 283
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
N E ++F++D ++G + R SLD EK Y + ++ D
Sbjct: 284 -NMESKAS----------EIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG----- 327
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTD-NPVIAKIKATDADVGANSAIR 188
L +T T+ + ++D NDN P+ T T S++ + + VIA + D D G N +
Sbjct: 328 LFTTTTMLITVVDVNDNAPEI---TITSSINSILENSPPGTVIALLNVQDQDSGENGQVS 384
Query: 189 YAIIGGNTQMQFSIDSLSGDV-SLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
I + F ++ G+ L+ + LD E V+SY + + A D GSP S T + +
Sbjct: 385 CFI---PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWL 441
Query: 246 NIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-N 304
N+ D NDN P F S + + EN P G SI V A D D NA +TY++TD G
Sbjct: 442 NVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVP 501
Query: 305 VDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXX 364
+ ++I+ +G +Y D E +L V A D GDPP S+ +
Sbjct: 502 LSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAP 561
Query: 365 XFM------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSIT 415
+ G VELA PG V + A D D L Y + + G F++
Sbjct: 562 EILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVG 621
Query: 416 SQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A++ V
Sbjct: 622 EHTGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEV 672
Score = 122 bits (293), Expect = 2e-26
Identities = 89/281 (31%), Positives = 132/281 (46%), Gaps = 18/281 (6%)
Query: 522 QQFVINPQTGAITTNKLLDR----ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDN 577
Q F +NP++G++ T +DR ET+S L + V VE+ ++D+NDN
Sbjct: 74 QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELL---VEDTLKIYGVEVEIIDINDN 130
Query: 578 EPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSF--VIDPA 635
P F++ + E A+ G + A D DVG+N Y+L P + D A
Sbjct: 131 APSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGA 190
Query: 636 SG-VIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
+ +LDRE A H L A+DGG P + V + + + D+ND P+F
Sbjct: 191 KNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRV 250
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMV 752
+ EN GT + + A DPDEG N V YS + + S F L+++ G E+
Sbjct: 251 SVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG----EVQVRG 306
Query: 753 DLDYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
LD+E R YE+ I+ L+ + I V DVNDNAP
Sbjct: 307 SLDFEKYR-FYEMEIQGQDGGGLFTTTTMLITVVDVNDNAP 346
Score = 81.4 bits (192), Expect = 4e-14
Identities = 63/247 (25%), Positives = 102/247 (41%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H +NV D ND+ PVF Y A + E G ++ ++ A D D +NA V Y++ T
Sbjct: 438 HVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSL---TD 494
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
DT+ + I+ +G L S D E+ + V A D P
Sbjct: 495 DTVQ-----------GVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDP-- 541
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDI-----SVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN P+ + S ++ K+ A D D G
Sbjct: 542 -PLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ + F++ +G+V + L LV+ QD G P S T
Sbjct: 601 QNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT 660
Query: 243 LLINIRD 249
L + + D
Sbjct: 661 LTVAVAD 667
Score = 64.5 bits (150), Expect = 5e-09
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 18/286 (6%)
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGS---FVIDPASGVIRTNKALDRESVATHDLKA 657
S VG D+GL R + + G F ++P SG + T +DRE + + +
Sbjct: 44 SFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELC-ETVSS 102
Query: 658 VAIDGGTPPQSSTVIVHIKIE--DINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPD 715
++ + + I +++E DIND+ P F+ D + +SE++ G A DPD
Sbjct: 103 CFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPD 162
Query: 716 EGPNAVVHYSIKGGDDSNSFSLETR---QGSDKAELVTMVDLDYESPRKKYELV--IRAA 770
G N++ Y + +N FSL+ R G+ ELV LD E L+ +
Sbjct: 163 VGVNSLQSYQL---SPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGG 219
Query: 771 SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAYDAD--VTDKLQ 828
P V + ++V DVND+ P+ + ++ V A D D + ++
Sbjct: 220 DPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVM 279
Query: 829 Y--RILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDG 872
Y R + + + L+ TG + + L+ + ME+ DG
Sbjct: 280 YSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDG 325
>AF152511-1|AAD43771.1| 820|Homo sapiens protocadherin gamma A4
short form protein protein.
Length = 820
Score = 221 bits (541), Expect = 2e-56
Identities = 188/611 (30%), Positives = 277/611 (45%), Gaps = 38/611 (6%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG L+T +DRE++ + T+ + D + + V IID NDN P
Sbjct: 74 LFALNPRSGTLVTAGRIDREELCDRSPNC-VTNLEILLEDTVK-ILRVEVEIIDVNDNPP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPV--IAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
F + + V E+ +NP +A D DVG NS Y + N+ FS+D S
Sbjct: 132 SFGTEQREIKVAEN----ENPGARFPLPEAFDPDVGVNSLQGYQL---NSNGYFSLDVQS 184
Query: 207 G-------DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
G ++ L + LD E+ + LV+ A DGG P RS T ++LI + D NDNAP F
Sbjct: 185 GADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQ 244
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ SV ENVP+G ++ V+A D DEG N ++TY+ + + ++ SG +
Sbjct: 245 PEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSF--RKVRDKISQLFQLNSLSGDIT 302
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
G LD E Y + V A DG P A + + E
Sbjct: 303 ILGGLDYEDSGFYDIDVEAHDG--PGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESS 360
Query: 380 PPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYV 438
PGT + D+D N L N T N L+T + LD ++ Y
Sbjct: 361 SPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLT-HRTLDREEVSEYN 419
Query: 439 LTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
+TV+ATD G S + + + D N+ P F +A Y+A + E+ P G ++L ++A D
Sbjct: 420 ITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDP 479
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
D G NA+ITYSL+ + A IN TG + D E L +TA D
Sbjct: 480 DSGDNARITYSLAEDTFQGAPL--SSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDS 537
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-------IMEDALVGTSVSQVGATDAD 609
G P LS + + V+D NDN P + + A G V++V A D D
Sbjct: 538 GDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRD 597
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQS 668
G N + Y L K E G F + +G +RT +A LDR+++ L V D G PP S
Sbjct: 598 SGQNAWLSYSL-LKSSEPGLFAVGLHTGEVRTARALLDRDALKQR-LVVVVQDHGQPPLS 655
Query: 669 STVIVHIKIED 679
+TV + + + D
Sbjct: 656 ATVTLTVAVAD 666
Score = 211 bits (516), Expect = 2e-53
Identities = 180/614 (29%), Positives = 281/614 (45%), Gaps = 38/614 (6%)
Query: 194 GNTQMQFSIDSLSGDVSLVKTLDYEQV--RSYRLVIRAQDGGSPSRSNTTQLL---INIR 248
G TQ+ F+++ SG + +D E++ RS V + +T ++L + I
Sbjct: 70 GRTQL-FALNPRSGTLVTAGRIDREELCDRSPNCVTNLEI----LLEDTVKILRVEVEII 124
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F T + V+EN G +A+D D GVN+ Y + Y ++D+
Sbjct: 125 DVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYF-SLDVQ 183
Query: 309 ITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
D + + LDRE +A + L++TA DGGDP RS TA F
Sbjct: 184 SGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFT 243
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR--GLITV 425
+Y V + E+ P GT ++T+ ATD DE + R + S Q G IT+
Sbjct: 244 QPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITI 303
Query: 426 AQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD++ Y + V A D G + V + + D N+ AP T+SV E + G
Sbjct: 304 LGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPG 363
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
T + + + DSD G N +T S+ + + + + T++ LDRE +S
Sbjct: 364 TVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYY-------RLLTHRTLDREEVS 416
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
Y +TVTA D G P LS T + + V+D+NDN P F Y+A I E+ G S+ + A
Sbjct: 417 EYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTA 476
Query: 606 TDADVGLNGRIHYELDPKDREEG----SFV-IDPASGVIRTNKALDRESVATHDLKAVAI 660
D D G N RI Y L +D +G S+V I+ +G++ + D E L A
Sbjct: 477 QDPDSGDNARITYSL-AEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTAS 535
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPP-----VFESDCLTFY--ISENSPIGTTIGEIRAHD 713
D G PP SS V + + + D ND+ P F +D T ++ G + ++ A D
Sbjct: 536 DSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVD 595
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASP 772
D G NA + YS+ + F++ G + LD ++ +++ +V++ P
Sbjct: 596 RDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTARAL---LDRDALKQRLVVVVQDHGQP 652
Query: 773 PLWNDVRVEILVTD 786
PL V + + V D
Sbjct: 653 PLSATVTLTVAVAD 666
Score = 203 bits (496), Expect = 6e-51
Identities = 157/498 (31%), Positives = 241/498 (48%), Gaps = 30/498 (6%)
Query: 311 IDPRSGWVYTSGQLDRETQA-KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE + VT + F
Sbjct: 77 LNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTE 136
Query: 370 QYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGR-GL---- 422
Q E+++AE+E PG A D D N L Y++ N+ G FS+ Q+G G+
Sbjct: 137 QREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQL---NSNGYFSLDVQSGADGIKYPE 193
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD ++E + L ++A D G RS TA + I + D N+ APVF Y SV E
Sbjct: 194 LVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ P+GT +L V ATD D G N +TYS ++ ++ Q F +N +G IT LD
Sbjct: 254 NVPVGTRLLTVKATDPDEGANGDVTYSFR-KVRDKI----SQLFQLNSLSGDITILGGLD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A DG P L + V ++V+D NDN P T+++ E + GT +
Sbjct: 309 YEDSGFYDIDVEAHDG--PGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVI 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV---IRTNKALDRESVATHDLKA 657
+ D+D G NG + + + F ++ G + T++ LDRE V+ +++
Sbjct: 367 ALFNVHDSDSGGNGLVTCSIP----DNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITV 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP S+ + +++ DIND+PP F + YI EN+P G +I + A DPD G
Sbjct: 423 TATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSG 482
Query: 718 PNAVVHYSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPL 774
NA + YS+ + S S+ L + DYE R L+ + S PPL
Sbjct: 483 DNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPL 542
Query: 775 WNDVRVEILVTDVNDNAP 792
++V + + V D NDN P
Sbjct: 543 SSNVSLSLFVLDQNDNVP 560
Score = 200 bits (487), Expect = 8e-50
Identities = 174/585 (29%), Positives = 267/585 (45%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND+ P F +Q E V E + G +A D D+G N+ Y + +
Sbjct: 120 EVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFS 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L+ + DG + L+ +LDRE+ A + +++ A D PV
Sbjct: 180 LDVQSGA----------------DGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA I + ++D NDN P F++ Y VSV E++ V + +KATD D GAN +
Sbjct: 223 --SGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTR--LLTVKATDPDEGANGDVT 278
Query: 189 YAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ + F ++SLSGD++++ LDYE Y + + A DG P +++L+
Sbjct: 279 YSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDG--PGLRARSKVLVT 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D NDNAP + SV E+ G I +D+D G N +T ++ D +
Sbjct: 337 VLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPD-------N 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP T++ G Y T LDRE ++Y + VTATD G PP S
Sbjct: 390 LPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G ++++TA D D DN R+ Y + +G S S N
Sbjct: 450 PTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINS 509
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ D++Q R L ++A+DSG S + + + D N+ P ++ P
Sbjct: 510 NTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPT 569
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++YSL S+E F +
Sbjct: 570 DGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLK--SSE-----PGLFAVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QRLVVVVQDHGQPPLSATVTLTVAVAD 666
Score = 169 bits (412), Expect = 9e-41
Identities = 136/496 (27%), Positives = 220/496 (44%), Gaps = 42/496 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I ++D ND++PVF +Y SVRE GT +LT+KATD D G N +V Y+ V
Sbjct: 230 IILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKV----- 284
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ +F+++ SG + LD E Y + V+A D L
Sbjct: 285 ------------RDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHD-----GPGL 327
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ + + V ++D+NDN P+ + + T SV E S + VIA D+D G N + +
Sbjct: 328 RARSKVLVTVLDENDNAPEVTVTSLTSSVQE--SSSPGTVIALFNVHDSDSGGNGLVTCS 385
Query: 191 IIGGNTQMQFSIDSLSGDVSLV---KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I + F+++ G+ + +TLD E+V Y + + A D G+P S T + + +
Sbjct: 386 I---PDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQV 442
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NVD 306
D+NDN P F + + + EN P G SI+ + A D D G NA +TY++ + + G +
Sbjct: 443 MDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLS 502
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
++I+ +G +Y D E QLL+TA+D GDPP S+ +
Sbjct: 503 SYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEI 562
Query: 367 M------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G VELA G V + A D D L Y + + G F++
Sbjct: 563 LYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLH 622
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTAS 477
G + A+ L + + L V D G +A V + + A++ V +
Sbjct: 623 TGE--VRTARALLDRDALKQRLVVVVQDHGQPPLSATVTLTVAVADSIPDVLADLGSLKP 680
Query: 478 VFEDAPIGTTVLVVSA 493
+ G T+ +V A
Sbjct: 681 SADPDDSGLTLYLVVA 696
Score = 124 bits (299), Expect = 5e-27
Identities = 103/327 (31%), Positives = 148/327 (45%), Gaps = 26/327 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SVFE+ G+ VV D+G+ + I + Q F +NP++G + T
Sbjct: 34 SVFEEQEEGS---VVGNIAKDLGLAPRELAERGVRIVSRG---RTQLFALNPRSGTLVTA 87
Query: 537 KLLDRETMSGYLLT-VTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + VT + + VE+ ++DVNDN P F + + E+
Sbjct: 88 GRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENEN 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV-------IRTNKALDRE 648
G A D DVG+N Y+L+ G F +D SG + +ALDRE
Sbjct: 148 PGARFPLPEAFDPDVGVNSLQGYQLN----SNGYFSLDVQSGADGIKYPELVLERALDRE 203
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A H L A DGG P +S T + I + D ND+ PVF + EN P+GT +
Sbjct: 204 EEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLT 263
Query: 709 IRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
++A DPDEG N V YS + D S F L + G ++ + LDYE Y++
Sbjct: 264 VKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSG----DITILGGLDYED-SGFYDID 318
Query: 767 IRA-ASPPLWNDVRVEILVTDVNDNAP 792
+ A P L +V + V D NDNAP
Sbjct: 319 VEAHDGPGLRARSKVLVTVLDENDNAP 345
Score = 91.9 bits (218), Expect = 3e-17
Identities = 63/247 (25%), Positives = 106/247 (42%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V+D ND+ P F Y A + E G ++L++ A D D G NA + Y++
Sbjct: 437 HISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSL---AE 493
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
DT + I+ +G L S D E+ +L+ A+D P
Sbjct: 494 DTFQ-----------GAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDP-- 540
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDI-----SVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN P+ T+ + S ++ K+ A D D G
Sbjct: 541 -PLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSG 599
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y+++ + F++ +G+V + L RLV+ QD G P S T
Sbjct: 600 QNAWLSYSLLKSSEPGLFAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQPPLSATVT 659
Query: 243 LLINIRD 249
L + + D
Sbjct: 660 LTVAVAD 666
Score = 74.1 bits (174), Expect = 6e-12
Identities = 84/326 (25%), Positives = 138/326 (42%), Gaps = 21/326 (6%)
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGS---FVIDPASGVIRTNKALDRESVATHDLKA 657
S VG D+GL R E + G F ++P SG + T +DRE +
Sbjct: 43 SVVGNIAKDLGLAPRELAERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNC 102
Query: 658 VA-IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
V ++ + V ++I D+ND+PP F ++ ++EN G A DPD
Sbjct: 103 VTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDV 162
Query: 717 GPNAVVHYSIKGGDDSNSFSLETRQGSD---KAELVTMVDLDYESPRKKYELVIRA---A 770
G N++ Y + + + FSL+ + G+D ELV LD E + LV+ A
Sbjct: 163 GVNSLQGYQL---NSNGYFSLDVQSGADGIKYPELVLERALDREE-EAVHHLVLTAFDGG 218
Query: 771 SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGP-FGRVPAYDADVTDK--- 826
P R+ I++ D NDNAPV + + ++ PVG V A D D
Sbjct: 219 DPVRSGTARILIILVDTNDNAPVFTQPE-YHVSVRENVPVGTRLLTVKATDPDEGANGDV 277
Query: 827 -LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVR 885
+R + + L LN +G +T+ L+ ++V DG ++A ++ V
Sbjct: 278 TYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDGPG-LRARSKVLVT 336
Query: 886 LITEEMLLNSITVRLNDMTAEQFLSP 911
++ E +TV + ++ SP
Sbjct: 337 VLDENDNAPEVTVTSLTSSVQESSSP 362
>AF152324-1|AAD43718.1| 931|Homo sapiens protocadherin gamma A4
protein.
Length = 931
Score = 221 bits (541), Expect = 2e-56
Identities = 188/611 (30%), Positives = 277/611 (45%), Gaps = 38/611 (6%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG L+T +DRE++ + T+ + D + + V IID NDN P
Sbjct: 74 LFALNPRSGTLVTAGRIDREELCDRSPNC-VTNLEILLEDTVK-ILRVEVEIIDVNDNPP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPV--IAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
F + + V E+ +NP +A D DVG NS Y + N+ FS+D S
Sbjct: 132 SFGTEQREIKVAEN----ENPGARFPLPEAFDPDVGVNSLQGYQL---NSNGYFSLDVQS 184
Query: 207 G-------DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYT 259
G ++ L + LD E+ + LV+ A DGG P RS T ++LI + D NDNAP F
Sbjct: 185 GADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQ 244
Query: 260 SLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVY 319
+ SV ENVP+G ++ V+A D DEG N ++TY+ + + ++ SG +
Sbjct: 245 PEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSF--RKVRDKISQLFQLNSLSGDIT 302
Query: 320 TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDE 379
G LD E Y + V A DG P A + + E
Sbjct: 303 ILGGLDYEDSGFYDIDVEAHDG--PGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESS 360
Query: 380 PPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYV 438
PGT + D+D N L N T N L+T + LD ++ Y
Sbjct: 361 SPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLT-HRTLDREEVSEYN 419
Query: 439 LTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDS 496
+TV+ATD G S + + + D N+ P F +A Y+A + E+ P G ++L ++A D
Sbjct: 420 ITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDP 479
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
D G NA+ITYSL+ + A IN TG + D E L +TA D
Sbjct: 480 DSGDNARITYSLAEDTFQGAPL--SSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDS 537
Query: 557 GVPSLSDTTDVEISVVDVNDNEPVFKQQLYTAN-------IMEDALVGTSVSQVGATDAD 609
G P LS + + V+D NDN P + + A G V++V A D D
Sbjct: 538 GDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRD 597
Query: 610 VGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQS 668
G N + Y L K E G F + +G +RT +A LDR+++ L V D G PP S
Sbjct: 598 SGQNAWLSYSL-LKSSEPGLFAVGLHTGEVRTARALLDRDALKQR-LVVVVQDHGQPPLS 655
Query: 669 STVIVHIKIED 679
+TV + + + D
Sbjct: 656 ATVTLTVAVAD 666
Score = 211 bits (516), Expect = 2e-53
Identities = 180/614 (29%), Positives = 281/614 (45%), Gaps = 38/614 (6%)
Query: 194 GNTQMQFSIDSLSGDVSLVKTLDYEQV--RSYRLVIRAQDGGSPSRSNTTQLL---INIR 248
G TQ+ F+++ SG + +D E++ RS V + +T ++L + I
Sbjct: 70 GRTQL-FALNPRSGTLVTAGRIDREELCDRSPNCVTNLEI----LLEDTVKILRVEVEII 124
Query: 249 DVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLP 308
DVNDN P F T + V+EN G +A+D D GVN+ Y + Y ++D+
Sbjct: 125 DVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYF-SLDVQ 183
Query: 309 ITIDP-RSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFM 367
D + + LDRE +A + L++TA DGGDP RS TA F
Sbjct: 184 SGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFT 243
Query: 368 PGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGGNTRGRFSITSQNGR--GLITV 425
+Y V + E+ P GT ++T+ ATD DE + R + S Q G IT+
Sbjct: 244 QPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITI 303
Query: 426 AQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD++ Y + V A D G + V + + D N+ AP T+SV E + G
Sbjct: 304 LGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPG 363
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
T + + + DSD G N +T S+ + + + + T++ LDRE +S
Sbjct: 364 TVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYY-------RLLTHRTLDREEVS 416
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
Y +TVTA D G P LS T + + V+D+NDN P F Y+A I E+ G S+ + A
Sbjct: 417 EYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTA 476
Query: 606 TDADVGLNGRIHYELDPKDREEG----SFV-IDPASGVIRTNKALDRESVATHDLKAVAI 660
D D G N RI Y L +D +G S+V I+ +G++ + D E L A
Sbjct: 477 QDPDSGDNARITYSL-AEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTAS 535
Query: 661 DGGTPPQSSTVIVHIKIEDINDSPP-----VFESDCLTFY--ISENSPIGTTIGEIRAHD 713
D G PP SS V + + + D ND+ P F +D T ++ G + ++ A D
Sbjct: 536 DSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVD 595
Query: 714 PDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR-AASP 772
D G NA + YS+ + F++ G + LD ++ +++ +V++ P
Sbjct: 596 RDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTARAL---LDRDALKQRLVVVVQDHGQP 652
Query: 773 PLWNDVRVEILVTD 786
PL V + + V D
Sbjct: 653 PLSATVTLTVAVAD 666
Score = 203 bits (496), Expect = 6e-51
Identities = 157/498 (31%), Positives = 241/498 (48%), Gaps = 30/498 (6%)
Query: 311 IDPRSGWVYTSGQLDRETQA-KYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPG 369
++PRSG + T+G++DRE + VT + F
Sbjct: 77 LNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTE 136
Query: 370 QYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGR-GL---- 422
Q E+++AE+E PG A D D N L Y++ N+ G FS+ Q+G G+
Sbjct: 137 QREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQL---NSNGYFSLDVQSGADGIKYPE 193
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFE 480
+ + + LD ++E + L ++A D G RS TA + I + D N+ APVF Y SV E
Sbjct: 194 LVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRE 253
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+ P+GT +L V ATD D G N +TYS ++ ++ Q F +N +G IT LD
Sbjct: 254 NVPVGTRLLTVKATDPDEGANGDVTYSFR-KVRDKI----SQLFQLNSLSGDITILGGLD 308
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSV 600
E Y + V A DG P L + V ++V+D NDN P T+++ E + GT +
Sbjct: 309 YEDSGFYDIDVEAHDG--PGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVI 366
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV---IRTNKALDRESVATHDLKA 657
+ D+D G NG + + + F ++ G + T++ LDRE V+ +++
Sbjct: 367 ALFNVHDSDSGGNGLVTCSIP----DNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITV 422
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
A D GTPP S+ + +++ DIND+PP F + YI EN+P G +I + A DPD G
Sbjct: 423 TATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSG 482
Query: 718 PNAVVHYSIKGGDDSNS-FSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS--PPL 774
NA + YS+ + S S+ L + DYE R L+ + S PPL
Sbjct: 483 DNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPL 542
Query: 775 WNDVRVEILVTDVNDNAP 792
++V + + V D NDN P
Sbjct: 543 SSNVSLSLFVLDQNDNVP 560
Score = 200 bits (487), Expect = 8e-50
Identities = 174/585 (29%), Positives = 267/585 (45%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND+ P F +Q E V E + G +A D D+G N+ Y + +
Sbjct: 120 EVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFS 179
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
L+ + DG + L+ +LDRE+ A + +++ A D PV
Sbjct: 180 LDVQSGA----------------DGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S TA I + ++D NDN P F++ Y VSV E++ V + +KATD D GAN +
Sbjct: 223 --SGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTR--LLTVKATDPDEGANGDVT 278
Query: 189 YAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ + F ++SLSGD++++ LDYE Y + + A DG P +++L+
Sbjct: 279 YSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDG--PGLRARSKVLVT 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D NDNAP + SV E+ G I +D+D G N +T ++ D +
Sbjct: 337 VLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPD-------N 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP T++ G Y T LDRE ++Y + VTATD G PP S
Sbjct: 390 LPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNP 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE-DN-RLHYEITGGNTRGR--FSITSQNG 419
F Y + E+ P G ++++TA D D DN R+ Y + +G S S N
Sbjct: 450 PTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINS 509
Query: 420 R-GLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ D++Q R L ++A+DSG S + + + D N+ P ++ P
Sbjct: 510 NTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPT 569
Query: 475 TASV-FEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP G V V A D D G NA ++YSL S+E F +
Sbjct: 570 DGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLK--SSE-----PGLFAVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QRLVVVVQDHGQPPLSATVTLTVAVAD 666
Score = 169 bits (412), Expect = 9e-41
Identities = 136/496 (27%), Positives = 220/496 (44%), Gaps = 42/496 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I ++D ND++PVF +Y SVRE GT +LT+KATD D G N +V Y+ V
Sbjct: 230 IILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKV----- 284
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
+ +F+++ SG + LD E Y + V+A D L
Sbjct: 285 ------------RDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHD-----GPGL 327
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ + + V ++D+NDN P+ + + T SV E S + VIA D+D G N + +
Sbjct: 328 RARSKVLVTVLDENDNAPEVTVTSLTSSVQE--SSSPGTVIALFNVHDSDSGGNGLVTCS 385
Query: 191 IIGGNTQMQFSIDSLSGDVSLV---KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I + F+++ G+ + +TLD E+V Y + + A D G+P S T + + +
Sbjct: 386 I---PDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQV 442
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NVD 306
D+NDN P F + + + EN P G SI+ + A D D G NA +TY++ + + G +
Sbjct: 443 MDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLS 502
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
++I+ +G +Y D E QLL+TA+D GDPP S+ +
Sbjct: 503 SYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEI 562
Query: 367 M------PGQYEVELA-EDEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G VELA G V + A D D L Y + + G F++
Sbjct: 563 LYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLH 622
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTAS 477
G + A+ L + + L V D G +A V + + A++ V +
Sbjct: 623 TGE--VRTARALLDRDALKQRLVVVVQDHGQPPLSATVTLTVAVADSIPDVLADLGSLKP 680
Query: 478 VFEDAPIGTTVLVVSA 493
+ G T+ +V A
Sbjct: 681 SADPDDSGLTLYLVVA 696
Score = 124 bits (299), Expect = 5e-27
Identities = 103/327 (31%), Positives = 148/327 (45%), Gaps = 26/327 (7%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SVFE+ G+ VV D+G+ + I + Q F +NP++G + T
Sbjct: 34 SVFEEQEEGS---VVGNIAKDLGLAPRELAERGVRIVSRG---RTQLFALNPRSGTLVTA 87
Query: 537 KLLDRETMSGYLLT-VTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + VT + + VE+ ++DVNDN P F + + E+
Sbjct: 88 GRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENEN 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV-------IRTNKALDRE 648
G A D DVG+N Y+L+ G F +D SG + +ALDRE
Sbjct: 148 PGARFPLPEAFDPDVGVNSLQGYQLN----SNGYFSLDVQSGADGIKYPELVLERALDRE 203
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGE 708
A H L A DGG P +S T + I + D ND+ PVF + EN P+GT +
Sbjct: 204 EEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLT 263
Query: 709 IRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDLDYESPRKKYELV 766
++A DPDEG N V YS + D S F L + G ++ + LDYE Y++
Sbjct: 264 VKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSG----DITILGGLDYED-SGFYDID 318
Query: 767 IRA-ASPPLWNDVRVEILVTDVNDNAP 792
+ A P L +V + V D NDNAP
Sbjct: 319 VEAHDGPGLRARSKVLVTVLDENDNAP 345
Score = 91.9 bits (218), Expect = 3e-17
Identities = 63/247 (25%), Positives = 106/247 (42%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V+D ND+ P F Y A + E G ++L++ A D D G NA + Y++
Sbjct: 437 HISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSL---AE 493
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
DT + I+ +G L S D E+ +L+ A+D P
Sbjct: 494 DTFQ-----------GAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDP-- 540
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDI-----SVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN P+ T+ + S ++ K+ A D D G
Sbjct: 541 -PLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSG 599
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y+++ + F++ +G+V + L RLV+ QD G P S T
Sbjct: 600 QNAWLSYSLLKSSEPGLFAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQPPLSATVT 659
Query: 243 LLINIRD 249
L + + D
Sbjct: 660 LTVAVAD 666
Score = 74.1 bits (174), Expect = 6e-12
Identities = 84/326 (25%), Positives = 138/326 (42%), Gaps = 21/326 (6%)
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGS---FVIDPASGVIRTNKALDRESVATHDLKA 657
S VG D+GL R E + G F ++P SG + T +DRE +
Sbjct: 43 SVVGNIAKDLGLAPRELAERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNC 102
Query: 658 VA-IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
V ++ + V ++I D+ND+PP F ++ ++EN G A DPD
Sbjct: 103 VTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDV 162
Query: 717 GPNAVVHYSIKGGDDSNSFSLETRQGSD---KAELVTMVDLDYESPRKKYELVIRA---A 770
G N++ Y + + + FSL+ + G+D ELV LD E + LV+ A
Sbjct: 163 GVNSLQGYQL---NSNGYFSLDVQSGADGIKYPELVLERALDREE-EAVHHLVLTAFDGG 218
Query: 771 SPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGP-FGRVPAYDADVTDK--- 826
P R+ I++ D NDNAPV + + ++ PVG V A D D
Sbjct: 219 DPVRSGTARILIILVDTNDNAPVFTQPE-YHVSVRENVPVGTRLLTVKATDPDEGANGDV 277
Query: 827 -LQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTDGVNEIKAMMQLSVR 885
+R + + L LN +G +T+ L+ ++V DG ++A ++ V
Sbjct: 278 TYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDGPG-LRARSKVLVT 336
Query: 886 LITEEMLLNSITVRLNDMTAEQFLSP 911
++ E +TV + ++ SP
Sbjct: 337 VLDENDNAPEVTVTSLTSSVQESSSP 362
>BC105636-1|AAI05637.1| 797|Homo sapiens protocadherin beta 9
protein.
Length = 797
Score = 221 bits (539), Expect = 4e-56
Identities = 179/601 (29%), Positives = 263/601 (43%), Gaps = 26/601 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 77 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVRDINDHSPVFR 134
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS-----LS 206
K + + E+ + + +A D D G NS Y I N+ I +
Sbjct: 135 HKEMVLKISENTA--EGTAFRLERAQDPDEGHNSIQNYTI-SSNSFFHIKISGSDEGMIY 191
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD E+ L + A DGGSPSRS T+ + I + DVNDN P+F +L++
Sbjct: 192 PELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNVPQFAQALYETQA 251
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDR 326
EN P+G IV+V A DAD GVNAE++Y+ D + ++ I+P SG ++ LD
Sbjct: 252 PENSPVGSLIVKVSAGDADSGVNAEVSYSFFDA--SEDILTTFQINPFSGEIFLRELLDY 309
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
E Y++ + A DGG SA T + +AE+ PG +
Sbjct: 310 ELVNSYKINIQAMDGGG--LSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLA 366
Query: 387 TLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
D D + F S + ++ LD + + Y +T++ TD
Sbjct: 367 VFKIKDRDSGENGKTICYVQDNLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDL 426
Query: 447 G-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G R T + + ++D N+ AP F YT V E+ + VSATD D G NAQ+
Sbjct: 427 GTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQV 486
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
TYSL + IN G + + LD E + + V A D G P+LS
Sbjct: 487 TYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFDFRVGASDRGSPALSSE 544
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGRIHY 618
V + V+D NDN P L + LV G V++V A D D G N + Y
Sbjct: 545 ALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSY 604
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
+L K E G F + +G +RT + L A H L + D G PP+S+T +H+ +
Sbjct: 605 QL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLV 663
Query: 679 D 679
D
Sbjct: 664 D 664
Score = 194 bits (473), Expect = 4e-48
Identities = 171/594 (28%), Positives = 261/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDHSPVF ++ + E + GT +A D D G N+
Sbjct: 110 MDDPFQIYRAELRVRDINDHSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQN 169
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + D I L+ +LDRE+ ++ + A
Sbjct: 170 YTI------------SSNSFFHIKISGSDEGMI---YPELVLDKALDREEQEELSLTLTA 214
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+TI + ++D NDN PQF++ Y E+ V +I K+ A DA
Sbjct: 215 LDGGSP---SRSGTSTIRIVVLDVNDNVPQFAQALYETQAPENSPV--GSLIVKVSAGDA 269
Query: 180 DVGANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ + + F I+ SG++ L + LDYE V SY++ I+A DGG S
Sbjct: 270 DSGVNAEVSYSFFDASEDILTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGGGLSA 329
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
T +LI + D NDN P S SV+EN P G + + D D G N + +
Sbjct: 330 RCT--VLIKVLDSNDNPPELIISSLSNSVAENSP-GIVLAVFKIKDRDSGENGKTICYVQ 386
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
D +LP + P Y T G LDRE++A+Y + +T TD G P +
Sbjct: 387 D-------NLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDLGTPRLKTEHSITL 439
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 440 QVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 499
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+
Sbjct: 500 LASLVSINADNGH--LFALRSLDYEALQAFDFRVGASDRGSPALSSEALVRVLVLDANDN 557
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 558 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 610
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 172 bits (419), Expect = 1e-41
Identities = 135/462 (29%), Positives = 222/462 (48%), Gaps = 32/462 (6%)
Query: 373 VELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI----TVAQ 427
++++E+ GT A D DE N + N+ I+ + G+I + +
Sbjct: 140 LKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIKISGSD-EGMIYPELVLDK 198
Query: 428 PLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD +++ LT++A D G RS T+ ++I + D N+ P F A Y E++P+G
Sbjct: 199 ALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNVPQFAQALYETQAPENSPVG 258
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
+ ++ VSA D+D G+NA+++YS + S + + F INP +G I +LLD E ++
Sbjct: 259 SLIVKVSAGDADSGVNAEVSYSFF-DASEDILT----TFQINPFSGEIFLRELLDYELVN 313
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
Y + + A DGG LS V I V+D NDN P + ++ E++ G ++
Sbjct: 314 SYKINIQAMDGG--GLSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLAVFKI 370
Query: 606 TDADVGLNGR-IHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKAVAID 661
D D G NG+ I Y D F + P+ ++ T ALDRES A +++ D
Sbjct: 371 KDRDSGENGKTICYVQDNLP-----FFLKPSVDNFYILMTEGALDRESKAEYNITITVTD 425
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAV 721
GTP + + +++ D+ND+ P F T ++ EN+ IG + A D D G NA
Sbjct: 426 LGTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQ 485
Query: 722 VHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V YS+ D + + +D L + LDYE+ + ++ + A+ SP L ++
Sbjct: 486 VTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFDFRVGASDRGSPALSSE 544
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
V +LV D NDN+P + + N C + P P Y
Sbjct: 545 ALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 97.1 bits (231), Expect = 8e-19
Identities = 85/279 (30%), Positives = 122/279 (43%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 73 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVRDINDHS 130
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D G N +Y + + G+
Sbjct: 131 PVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIK-ISGSDEGM 189
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T + I + D+ND+ P F
Sbjct: 190 IYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNVPQFAQALYET 249
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSP+G+ I ++ A D D G NA V YS D S + E+ L
Sbjct: 250 QAPENSPVGSLIVKVSAGDADSGVNAEVSYSF--FDASEDILTTFQINPFSGEIFLRELL 307
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L V I V D NDN P
Sbjct: 308 DYELV-NSYKINIQAMDGGGLSARCTVLIKVLDSNDNPP 345
Score = 72.9 bits (171), Expect = 1e-11
Identities = 72/261 (27%), Positives = 111/261 (42%), Gaps = 17/261 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 69 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDIND 128
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF + ISEN+ GT RA DPDEG N++ +Y+I SNSF G
Sbjct: 129 HSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTI----SSNSFFHIKISG 184
Query: 743 SDKAELVTMVDLDYESPRKKYE---LVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKD 796
SD+ + + LD R++ E L + A SP + I+V DVNDN P
Sbjct: 185 SDEGMIYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNVPQFAQ 244
Query: 797 FQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNANL--ILLNETTGSMTL 851
+ + PVG +V A DAD V ++ Y + L +N +G + L
Sbjct: 245 -ALYETQAPENSPVGSLIVKVSAGDADSGVNAEVSYSFFDASEDILTTFQINPFSGEIFL 303
Query: 852 SPQLNTNVPKLATMEVSVTDG 872
L+ + + + DG
Sbjct: 304 RELLDYELVNSYKINIQAMDG 324
>BC100672-1|AAI00673.1| 797|Homo sapiens protocadherin beta 9
protein.
Length = 797
Score = 221 bits (539), Expect = 4e-56
Identities = 179/601 (29%), Positives = 263/601 (43%), Gaps = 26/601 (4%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D +G LLT LDREK+ Q + D + + D ND+ P F
Sbjct: 77 LDSHTGNLLTNEKLDREKLCGPKEPCMLYFQI--LMDDPFQIYRAELRVRDINDHSPVFR 134
Query: 152 EKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDS-----LS 206
K + + E+ + + +A D D G NS Y I N+ I +
Sbjct: 135 HKEMVLKISENTA--EGTAFRLERAQDPDEGHNSIQNYTI-SSNSFFHIKISGSDEGMIY 191
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
++ L K LD E+ L + A DGGSPSRS T+ + I + DVNDN P+F +L++
Sbjct: 192 PELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNVPQFAQALYETQA 251
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDR 326
EN P+G IV+V A DAD GVNAE++Y+ D + ++ I+P SG ++ LD
Sbjct: 252 PENSPVGSLIVKVSAGDADSGVNAEVSYSFFDA--SEDILTTFQINPFSGEIFLRELLDY 309
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
E Y++ + A DGG SA T + +AE+ PG +
Sbjct: 310 ELVNSYKINIQAMDGGG--LSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLA 366
Query: 387 TLTATDADEDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
D D + F S + ++ LD + + Y +T++ TD
Sbjct: 367 VFKIKDRDSGENGKTICYVQDNLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDL 426
Query: 447 G-GRSDTA-MVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G R T + + ++D N+ AP F YT V E+ + VSATD D G NAQ+
Sbjct: 427 GTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQV 486
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDT 564
TYSL + IN G + + LD E + + V A D G P+LS
Sbjct: 487 TYSLLP--PQDPHLPLASLVSINADNGHLFALRSLDYEALQAFDFRVGASDRGSPALSSE 544
Query: 565 TDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGRIHY 618
V + V+D NDN P L + LV G V++V A D D G N + Y
Sbjct: 545 ALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSY 604
Query: 619 ELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIE 678
+L K E G F + +G +RT + L A H L + D G PP+S+T +H+ +
Sbjct: 605 QL-LKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLV 663
Query: 679 D 679
D
Sbjct: 664 D 664
Score = 194 bits (473), Expect = 4e-48
Identities = 171/594 (28%), Positives = 261/594 (43%), Gaps = 60/594 (10%)
Query: 1 MSVPFCIHQ-QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVE 59
M PF I++ ++ V D NDHSPVF ++ + E + GT +A D D G N+
Sbjct: 110 MDDPFQIYRAELRVRDINDHSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQN 169
Query: 60 YTIELVTADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKA 119
YTI + D I L+ +LDRE+ ++ + A
Sbjct: 170 YTI------------SSNSFFHIKISGSDEGMI---YPELVLDKALDREEQEELSLTLTA 214
Query: 120 TDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDA 179
D SP S T+TI + ++D NDN PQF++ Y E+ V +I K+ A DA
Sbjct: 215 LDGGSP---SRSGTSTIRIVVLDVNDNVPQFAQALYETQAPENSPV--GSLIVKVSAGDA 269
Query: 180 DVGANSAIRYAIIGGNTQM--QFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSR 237
D G N+ + Y+ + + F I+ SG++ L + LDYE V SY++ I+A DGG S
Sbjct: 270 DSGVNAEVSYSFFDASEDILTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGGGLSA 329
Query: 238 SNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
T +LI + D NDN P S SV+EN P G + + D D G N + +
Sbjct: 330 RCT--VLIKVLDSNDNPPELIISSLSNSVAENSP-GIVLAVFKIKDRDSGENGKTICYVQ 386
Query: 298 DKDYTGNVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXX 354
D +LP + P Y T G LDRE++A+Y + +T TD G P +
Sbjct: 387 D-------NLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDLGTPRLKTEHSITL 439
Query: 355 XXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN----- 407
F Y + + E+ P + +++ATD D + ++ Y +
Sbjct: 440 QVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLP 499
Query: 408 TRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNY 465
SI + NG + + LD++ + + V A+D G S A+V++ + DAN+
Sbjct: 500 LASLVSINADNGH--LFALRSLDYEALQAFDFRVGASDRGSPALSSEALVRVLVLDANDN 557
Query: 466 APV----FEN--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAH 519
+P +N AP T V A G V V A D D G NA ++Y L A
Sbjct: 558 SPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------AT 610
Query: 520 HDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
F + G + T +LL + + L V +D G P S T + + +VD
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 172 bits (419), Expect = 1e-41
Identities = 135/462 (29%), Positives = 222/462 (48%), Gaps = 32/462 (6%)
Query: 373 VELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI----TVAQ 427
++++E+ GT A D DE N + N+ I+ + G+I + +
Sbjct: 140 LKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIKISGSD-EGMIYPELVLDK 198
Query: 428 PLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIG 485
LD +++ LT++A D G RS T+ ++I + D N+ P F A Y E++P+G
Sbjct: 199 ALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNVPQFAQALYETQAPENSPVG 258
Query: 486 TTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMS 545
+ ++ VSA D+D G+NA+++YS + S + + F INP +G I +LLD E ++
Sbjct: 259 SLIVKVSAGDADSGVNAEVSYSFF-DASEDILT----TFQINPFSGEIFLRELLDYELVN 313
Query: 546 GYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGA 605
Y + + A DGG LS V I V+D NDN P + ++ E++ G ++
Sbjct: 314 SYKINIQAMDGG--GLSARCTVLIKVLDSNDNPPELIISSLSNSVAENS-PGIVLAVFKI 370
Query: 606 TDADVGLNGR-IHYELDPKDREEGSFVIDPASG---VIRTNKALDRESVATHDLKAVAID 661
D D G NG+ I Y D F + P+ ++ T ALDRES A +++ D
Sbjct: 371 KDRDSGENGKTICYVQDNLP-----FFLKPSVDNFYILMTEGALDRESKAEYNITITVTD 425
Query: 662 GGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAV 721
GTP + + +++ D+ND+ P F T ++ EN+ IG + A D D G NA
Sbjct: 426 LGTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQ 485
Query: 722 VHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAA---SPPLWND 777
V YS+ D + + +D L + LDYE+ + ++ + A+ SP L ++
Sbjct: 486 VTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-LQAFDFRVGASDRGSPALSSE 544
Query: 778 VRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
V +LV D NDN+P + + N C + P P Y
Sbjct: 545 ALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 97.1 bits (231), Expect = 8e-19
Identities = 85/279 (30%), Positives = 122/279 (43%), Gaps = 14/279 (5%)
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV---EISVVDVNDNE 578
Q +++ TG + TN+ LDRE + G + + D + E+ V D+ND+
Sbjct: 73 QYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQIL--MDDPFQIYRAELRVRDINDHS 130
Query: 579 PVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGV 638
PVF+ + I E+ GT+ A D D G N +Y + + G+
Sbjct: 131 PVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHIK-ISGSDEGM 189
Query: 639 IRT----NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
I +KALDRE L A+DGG+P +S T + I + D+ND+ P F
Sbjct: 190 IYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNVPQFAQALYET 249
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
ENSP+G+ I ++ A D D G NA V YS D S + E+ L
Sbjct: 250 QAPENSPVGSLIVKVSAGDADSGVNAEVSYSF--FDASEDILTTFQINPFSGEIFLRELL 307
Query: 755 DYESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
DYE Y++ I+A L V I V D NDN P
Sbjct: 308 DYELV-NSYKINIQAMDGGGLSARCTVLIKVLDSNDNPP 345
Score = 72.9 bits (171), Expect = 1e-11
Identities = 72/261 (27%), Positives = 111/261 (42%), Gaps = 17/261 (6%)
Query: 624 DREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI-VHIKIEDIND 682
D + ++D +G + TN+ LDRE + + + +++ DIND
Sbjct: 69 DDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDIND 128
Query: 683 SPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
PVF + ISEN+ GT RA DPDEG N++ +Y+I SNSF G
Sbjct: 129 HSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTI----SSNSFFHIKISG 184
Query: 743 SDKAELVTMVDLDYESPRKKYE---LVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKD 796
SD+ + + LD R++ E L + A SP + I+V DVNDN P
Sbjct: 185 SDEGMIYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNVPQFAQ 244
Query: 797 FQIIFNNYKDCFPVGP-FGRVPAYDAD--VTDKLQYRILSGNNANL--ILLNETTGSMTL 851
+ + PVG +V A DAD V ++ Y + L +N +G + L
Sbjct: 245 -ALYETQAPENSPVGSLIVKVSAGDADSGVNAEVSYSFFDASEDILTTFQINPFSGEIFL 303
Query: 852 SPQLNTNVPKLATMEVSVTDG 872
L+ + + + DG
Sbjct: 304 RELLDYELVNSYKINIQAMDG 324
>AF217742-1|AAK51610.1| 787|Homo sapiens protocadherin-beta15
protein.
Length = 787
Score = 221 bits (539), Expect = 4e-56
Identities = 181/604 (29%), Positives = 271/604 (44%), Gaps = 30/604 (4%)
Query: 91 RIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQF 150
++D ++G L+ LDREK+ T Q + + + + D ND+ P+F
Sbjct: 76 QLDLQTGQLILNEKLDREKLCGPTEPCIMHFQV--LLKKPLEVFRAELLVTDINDHSPEF 133
Query: 151 SEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG--- 207
E+ T+ + E S+ V KA D DVG+N+ Y I N+ S +
Sbjct: 134 PEREMTLKIPETSSL--GTVFPLKKARDLDVGSNNVQNYNI-SPNSHFHVSTRTRGDGRK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L LD E+ RL + A DGGSP RS T Q+LI + D NDNAP F +L++
Sbjct: 191 YPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQ 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
V EN P+G +V+V A D D G N E++Y++ + +D P + SG + +LD
Sbjct: 251 VPENSPVGSLVVKVSARDLDTGTNGEISYSLYYS--SQEIDKPFELSSLSGEIRLIKKLD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
ET + Y L + A+DGG S + + E+ P T V
Sbjct: 309 FETMSSYDLDIEASDGGG--LSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPE-TEV 365
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
D D E+ ++ I + + + +N L+T LD + Y +T++
Sbjct: 366 ALFRIRDRDSGENGKMICSIQ-DDVPFKLKPSVENFYRLVTEG-ALDRETRAEYNITITI 423
Query: 444 TDSG-GRSDTAM-VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G R T + + ++D N+ AP F YT V E+ + VSATD D G N
Sbjct: 424 TDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTN 483
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
AQ+TYSL + IN G + + LD E + + V A D G P+L
Sbjct: 484 AQVTYSLLP--PRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPAL 541
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGR 615
S V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 542 SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW 601
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y+L K E G F + +G +RT + L VA H L + D G PP+S+T + +
Sbjct: 602 LSYQL-LKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQV 660
Query: 676 KIED 679
+ D
Sbjct: 661 LLVD 664
Score = 198 bits (482), Expect = 3e-49
Identities = 170/585 (29%), Positives = 256/585 (43%), Gaps = 61/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D NDHSP F ++ + E +S GT KA D D+G N Y I
Sbjct: 120 ELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNI------- 172
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSD 128
+P V R DGR L+ LDRE+ A + + A D SP
Sbjct: 173 -SPN--------SHFHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S T I + ++D NDN P+F + Y V V E+ V ++ K+ A D D G N I
Sbjct: 223 --SGTVQILILVLDANDNAPEFVQALYEVQVPENSPV--GSLVVKVSARDLDTGTNGEIS 278
Query: 189 YAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y++ + ++ F + SLSG++ L+K LD+E + SY L I A DGG S + +
Sbjct: 279 YSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGG--GLSGKCSVSVK 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDN P S + EN P + + D D G N ++ ++ D D
Sbjct: 337 VLDVNDNFPELSISSLTSPIPENSP-ETEVALFRIRDRDSGENGKMICSIQD-------D 388
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+P + P Y T G LDRET+A+Y + +T TD G P +
Sbjct: 389 VPFKLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNA 448
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN-----TRGRFSITS 416
F Y + + E+ P + +++ATD D + ++ Y + SI +
Sbjct: 449 PAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINT 508
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV----FE 470
NG + Q LD++ + + V ATD G S A+V++ + DAN+ +P +
Sbjct: 509 DNGH--LFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQ 566
Query: 471 N--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
N AP T V A G V V A D D G NA ++Y L A F +
Sbjct: 567 NGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------ATEPGLFGVWA 619
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
G + T +LL ++ + L V +D G P S T +++ +VD
Sbjct: 620 HNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVD 664
Score = 182 bits (444), Expect = 1e-44
Identities = 147/556 (26%), Positives = 242/556 (43%), Gaps = 30/556 (5%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D+ND++P F + E +G +A D D G N Y ++ + +V
Sbjct: 123 VTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHF-HVS 181
Query: 307 LPITIDPRS-GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
D R + +LDRE QA+ +L +TA DGG PPRS T
Sbjct: 182 TRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPE 241
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEI--TGGNTRGRFSITSQNGRG 421
F+ YEV++ E+ P G+ VV ++A D D + + Y + + F ++S +G
Sbjct: 242 FVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGE- 300
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFED 481
I + + LDF+ Y L + A+D GG S V + + D N+ P + T+ + E+
Sbjct: 301 -IRLIKKLDFETMSSYDLDIEASDGGGLSGKCSVSVKVLDVNDNFPELSISSLTSPIPEN 359
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
+P T V + D D G N ++ S+ ++ + + + + T LDR
Sbjct: 360 SP-ETEVALFRIRDRDSGENGKMICSIQDDVPFKLKPSVENFY-------RLVTEGALDR 411
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVS 601
ET + Y +T+T D G P L + + V DVNDN P F Q YT + E+ +
Sbjct: 412 ETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIG 471
Query: 602 QVGATDADVGLNGRIHYEL----DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
V ATD D G N ++ Y L DP I+ +G + ++LD E++ + +
Sbjct: 472 SVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRV 531
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVF------ESDCLTFYISENSPIGTTIGEIRA 711
A D G P SS +V + + D ND+ P S T + + G + ++ A
Sbjct: 532 GATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVA 591
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK-AELVTMVDLDYESPRKKYELVIRAA 770
D D G NA + Y + + F + G + A L++ D+ + + LV
Sbjct: 592 VDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDV---AKHRLVVLVKDNG 648
Query: 771 SPPLWNDVRVEILVTD 786
PP +++L+ D
Sbjct: 649 EPPRSATATLQVLLVD 664
Score = 177 bits (430), Expect = 6e-43
Identities = 143/467 (30%), Positives = 222/467 (47%), Gaps = 28/467 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGL- 422
F + +++ E GT A D D +N +Y I+ + + T +GR
Sbjct: 133 FPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + LD +++ LT++A D G RS T + I + DAN+ AP F A Y V
Sbjct: 193 ELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVP 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E++P+G+ V+ VSA D D G N +I+YSL S++ + D+ F ++ +G I K L
Sbjct: 253 ENSPVGSLVVKVSARDLDTGTNGEISYSL--YYSSQEI---DKPFELSSLSGEIRLIKKL 307
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D ETMS Y L + A DGG LS V + V+DVNDN P T+ I E++ T
Sbjct: 308 DFETMSSYDLDIEASDGG--GLSGKCSVSVKVLDVNDNFPELSISSLTSPIPENS-PETE 364
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPA-SGVIR--TNKALDRESVATHDLK 656
V+ D D G NG++ + +++ F + P+ R T ALDRE+ A +++
Sbjct: 365 VALFRIRDRDSGENGKMICSI----QDDVPFKLKPSVENFYRLVTEGALDRETRAEYNIT 420
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
D GTP + + + + D+ND+ P F T ++ EN+ IG + A D D
Sbjct: 421 ITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDS 480
Query: 717 GPNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---P 772
G NA V YS+ D + + +D L + LDYE+ + +E + A P
Sbjct: 481 GTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEA-LQAFEFRVGATDRGFP 539
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V +LV D NDN+P + + N C + P P Y
Sbjct: 540 ALSSEALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 163 bits (395), Expect = 1e-38
Identities = 133/427 (31%), Positives = 194/427 (45%), Gaps = 22/427 (5%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE 515
++ +TD N+++P F T + E + +GT + A D DVG N Y++S
Sbjct: 120 ELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFH 179
Query: 516 AVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVN 575
P+ + + LDRE + LT+TA DGG P S T + I V+D N
Sbjct: 180 VSTRTRGDGRKYPE---LVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDAN 236
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDRE-EGSFVIDP 634
DN P F Q LY + E++ VG+ V +V A D D G NG I Y L +E + F +
Sbjct: 237 DNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSS 296
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
SG IR K LD E+++++DL A DGG S V +K+ D+ND+ P LT
Sbjct: 297 LSGEIRLIKKLDFETMSSYDLDIEASDGG--GLSGKCSVSVKVLDVNDNFPELSISSLTS 354
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I ENSP T + R D D G N + SI+ D F L+ + LVT L
Sbjct: 355 PIPENSP-ETEVALFRIRDRDSGENGKMICSIQ---DDVPFKLKP-SVENFYRLVTEGAL 409
Query: 755 DYESPRKKYELVIR---AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E+ R +Y + I +P L + + +LV+DVNDNAP ++ P
Sbjct: 410 DRET-RAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPAL 468
Query: 812 PFGRVPAYDAD--VTDKLQYRILSGNN-----ANLILLNETTGSMTLSPQLNTNVPKLAT 864
G V A D D ++ Y +L + +L+ +N G + L+ +
Sbjct: 469 HIGSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFE 528
Query: 865 MEVSVTD 871
V TD
Sbjct: 529 FRVGATD 535
Score = 134 bits (324), Expect = 4e-30
Identities = 130/482 (26%), Positives = 205/482 (42%), Gaps = 46/482 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND++P F YE V E + G+ V+ + A D D G N E+ Y++ + +
Sbjct: 230 ILVLDANDNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEID 289
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F + SG + LD E ++ Y + ++A+D L
Sbjct: 290 KP-----------------FELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGG-----L 327
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S ++ V ++D NDN+P+ S + T + E+ T+ +A + D D G N + +
Sbjct: 328 SGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETE---VALFRIRDRDSGENGKMICS 384
Query: 191 IIGGNTQMQFSID-SLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I + F + S+ LV LD E Y + I D G+P + + +
Sbjct: 385 I---QDDVPFKLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLV 441
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTGNVD 306
DVNDNAP F + + V EN I V A D D G NA++TY+ + +D +
Sbjct: 442 SDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPRDPHLPLT 501
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
++I+ +G ++ LD E ++ V ATD G P S+ A
Sbjct: 502 SLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFV 561
Query: 367 M-PGQY-EVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQN 418
+ P Q E P PG V + A D D L Y++ G F + + N
Sbjct: 562 LYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHN 621
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITD--ANNYAPVFENAPY 474
G + A+ L + ++ L V D+G RS TA +Q+ + D + Y P+ E AP
Sbjct: 622 GE--VRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVDGFSQPYLPLPEAAPA 679
Query: 475 TA 476
A
Sbjct: 680 QA 681
Score = 111 bits (267), Expect = 3e-23
Identities = 97/330 (29%), Positives = 150/330 (45%), Gaps = 24/330 (7%)
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
P SV E+ G+ V ++ +D+G+ + + +E ++Q ++ QTG
Sbjct: 30 PRRYSVMEETERGSFVANLA---NDLGLGVGELAERGARVVSE---DNEQGLQLDLQTGQ 83
Query: 533 ITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
+ N+ LDRE + G + + + E+ V D+ND+ P F ++ T I
Sbjct: 84 LILNEKLDREKLCGPTEPCIMHFQVLLKKPLEVFRAELLVTDINDHSPEFPEREMTLKIP 143
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKD------REEGSFVIDPASGVIRTNKAL 645
E + +GT A D DVG N +Y + P R G P V+ T L
Sbjct: 144 ETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPEL-VLDTE--L 200
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
DRE A L A+DGG+PP+S TV + I + D ND+ P F + ENSP+G+
Sbjct: 201 DREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVGSL 260
Query: 706 IGEIRAHDPDEGPNAVVHYSI--KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKY 763
+ ++ A D D G N + YS+ + F L + G E+ + LD+E+ Y
Sbjct: 261 VVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSG----EIRLIKKLDFET-MSSY 315
Query: 764 ELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
+L I A+ L V + V DVNDN P
Sbjct: 316 DLDIEASDGGGLSGKCSVSVKVLDVNDNFP 345
Score = 93.5 bits (222), Expect = 1e-17
Identities = 73/247 (29%), Positives = 113/247 (45%), Gaps = 23/247 (9%)
Query: 9 QQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
Q I VL D ND++P F Y VRE S + ++ ATD+D G NA+V Y++
Sbjct: 435 QSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL---- 490
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
L P D + + I+ +G L SLD E + + V ATD+ P
Sbjct: 491 ---LPPRDPHLP-------LTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPA 540
Query: 127 SDRLSSTATIHVNIIDDNDNYP--QFSEKTYTVSVDEDISVTDNP--VIAKIKATDADVG 182
LSS A + V ++D NDN P + + + E + P ++ K+ A D D G
Sbjct: 541 ---LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSG 597
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ F + + +G+V + L V +RLV+ +D G P RS T
Sbjct: 598 QNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATAT 657
Query: 243 LLINIRD 249
L + + D
Sbjct: 658 LQVLLVD 664
>AF152494-1|AAD43755.1| 787|Homo sapiens protocadherin beta 15
protein.
Length = 787
Score = 221 bits (539), Expect = 4e-56
Identities = 181/604 (29%), Positives = 271/604 (44%), Gaps = 30/604 (4%)
Query: 91 RIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQF 150
++D ++G L+ LDREK+ T Q + + + + D ND+ P+F
Sbjct: 76 QLDLQTGQLILNEKLDREKLCGPTEPCIMHFQV--LLKKPLEVFRAELLVTDINDHSPEF 133
Query: 151 SEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG--- 207
E+ T+ + E S+ V KA D DVG+N+ Y I N+ S +
Sbjct: 134 PEREMTLKIPETSSL--GTVFPLKKARDLDVGSNNVQNYNI-SPNSHFHVSTRTRGDGRK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L LD E+ RL + A DGGSP RS T Q+LI + D NDNAP F +L++
Sbjct: 191 YPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQ 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
V EN P+G +V+V A D D G N E++Y++ + +D P + SG + +LD
Sbjct: 251 VPENSPVGSLVVKVSARDLDTGTNGEISYSLYYS--SQEIDKPFELSSLSGEIRLIKKLD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
ET + Y L + A+DGG S + + E+ P T V
Sbjct: 309 FETMSSYDLDIEASDGGG--LSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPE-TEV 365
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
D D E+ ++ I + + + +N L+T LD + Y +T++
Sbjct: 366 ALFRIRDRDSGENGKMICSIQ-DDVPFKLKPSVENFYRLVTEG-ALDRETRAEYNITITI 423
Query: 444 TDSG-GRSDTAM-VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G R T + + ++D N+ AP F YT V E+ + VSATD D G N
Sbjct: 424 TDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTN 483
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
AQ+TYSL + IN G + + LD E + + V A D G P+L
Sbjct: 484 AQVTYSLLP--PRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPAL 541
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGR 615
S V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 542 SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW 601
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y+L K E G F + +G +RT + L VA H L + D G PP+S+T + +
Sbjct: 602 LSYQL-LKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQV 660
Query: 676 KIED 679
+ D
Sbjct: 661 LLVD 664
Score = 198 bits (482), Expect = 3e-49
Identities = 170/585 (29%), Positives = 256/585 (43%), Gaps = 61/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D NDHSP F ++ + E +S GT KA D D+G N Y I
Sbjct: 120 ELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNI------- 172
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSD 128
+P V R DGR L+ LDRE+ A + + A D SP
Sbjct: 173 -SPN--------SHFHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S T I + ++D NDN P+F + Y V V E+ V ++ K+ A D D G N I
Sbjct: 223 --SGTVQILILVLDANDNAPEFVQALYEVQVPENSPV--GSLVVKVSARDLDTGTNGEIS 278
Query: 189 YAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y++ + ++ F + SLSG++ L+K LD+E + SY L I A DGG S + +
Sbjct: 279 YSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGG--GLSGKCSVSVK 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDN P S + EN P + + D D G N ++ ++ D D
Sbjct: 337 VLDVNDNFPELSISSLTSPIPENSP-ETEVALFRIRDRDSGENGKMICSIQD-------D 388
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+P + P Y T G LDRET+A+Y + +T TD G P +
Sbjct: 389 VPFKLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNA 448
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN-----TRGRFSITS 416
F Y + + E+ P + +++ATD D + ++ Y + SI +
Sbjct: 449 PAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINT 508
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV----FE 470
NG + Q LD++ + + V ATD G S A+V++ + DAN+ +P +
Sbjct: 509 DNGH--LFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQ 566
Query: 471 N--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
N AP T V A G V V A D D G NA ++Y L A F +
Sbjct: 567 NGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------ATEPGLFGVWA 619
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
G + T +LL ++ + L V +D G P S T +++ +VD
Sbjct: 620 HNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVD 664
Score = 182 bits (444), Expect = 1e-44
Identities = 147/556 (26%), Positives = 242/556 (43%), Gaps = 30/556 (5%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D+ND++P F + E +G +A D D G N Y ++ + +V
Sbjct: 123 VTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHF-HVS 181
Query: 307 LPITIDPRS-GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
D R + +LDRE QA+ +L +TA DGG PPRS T
Sbjct: 182 TRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPE 241
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEI--TGGNTRGRFSITSQNGRG 421
F+ YEV++ E+ P G+ VV ++A D D + + Y + + F ++S +G
Sbjct: 242 FVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGE- 300
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFED 481
I + + LDF+ Y L + A+D GG S V + + D N+ P + T+ + E+
Sbjct: 301 -IRLIKKLDFETMSSYDLDIEASDGGGLSGKCSVSVKVLDVNDNFPELSISSLTSPIPEN 359
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
+P T V + D D G N ++ S+ ++ + + + + T LDR
Sbjct: 360 SP-ETEVALFRIRDRDSGENGKMICSIQDDVPFKLKPSVENFY-------RLVTEGALDR 411
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVS 601
ET + Y +T+T D G P L + + V DVNDN P F Q YT + E+ +
Sbjct: 412 ETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIG 471
Query: 602 QVGATDADVGLNGRIHYEL----DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
V ATD D G N ++ Y L DP I+ +G + ++LD E++ + +
Sbjct: 472 SVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRV 531
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVF------ESDCLTFYISENSPIGTTIGEIRA 711
A D G P SS +V + + D ND+ P S T + + G + ++ A
Sbjct: 532 GATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVA 591
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK-AELVTMVDLDYESPRKKYELVIRAA 770
D D G NA + Y + + F + G + A L++ D+ + + LV
Sbjct: 592 VDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDV---AKHRLVVLVKDNG 648
Query: 771 SPPLWNDVRVEILVTD 786
PP +++L+ D
Sbjct: 649 EPPRSATATLQVLLVD 664
Score = 177 bits (430), Expect = 6e-43
Identities = 143/467 (30%), Positives = 222/467 (47%), Gaps = 28/467 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGL- 422
F + +++ E GT A D D +N +Y I+ + + T +GR
Sbjct: 133 FPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + LD +++ LT++A D G RS T + I + DAN+ AP F A Y V
Sbjct: 193 ELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVP 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E++P+G+ V+ VSA D D G N +I+YSL S++ + D+ F ++ +G I K L
Sbjct: 253 ENSPVGSLVVKVSARDLDTGTNGEISYSL--YYSSQEI---DKPFELSSLSGEIRLIKKL 307
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D ETMS Y L + A DGG LS V + V+DVNDN P T+ I E++ T
Sbjct: 308 DFETMSSYDLDIEASDGG--GLSGKCSVSVKVLDVNDNFPELSISSLTSPIPENS-PETE 364
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPA-SGVIR--TNKALDRESVATHDLK 656
V+ D D G NG++ + +++ F + P+ R T ALDRE+ A +++
Sbjct: 365 VALFRIRDRDSGENGKMICSI----QDDVPFKLKPSVENFYRLVTEGALDRETRAEYNIT 420
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
D GTP + + + + D+ND+ P F T ++ EN+ IG + A D D
Sbjct: 421 ITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDS 480
Query: 717 GPNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---P 772
G NA V YS+ D + + +D L + LDYE+ + +E + A P
Sbjct: 481 GTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEA-LQAFEFRVGATDRGFP 539
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V +LV D NDN+P + + N C + P P Y
Sbjct: 540 ALSSEALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 163 bits (395), Expect = 1e-38
Identities = 133/427 (31%), Positives = 194/427 (45%), Gaps = 22/427 (5%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE 515
++ +TD N+++P F T + E + +GT + A D DVG N Y++S
Sbjct: 120 ELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFH 179
Query: 516 AVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVN 575
P+ + + LDRE + LT+TA DGG P S T + I V+D N
Sbjct: 180 VSTRTRGDGRKYPE---LVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDAN 236
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDRE-EGSFVIDP 634
DN P F Q LY + E++ VG+ V +V A D D G NG I Y L +E + F +
Sbjct: 237 DNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSS 296
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
SG IR K LD E+++++DL A DGG S V +K+ D+ND+ P LT
Sbjct: 297 LSGEIRLIKKLDFETMSSYDLDIEASDGG--GLSGKCSVSVKVLDVNDNFPELSISSLTS 354
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I ENSP T + R D D G N + SI+ D F L+ + LVT L
Sbjct: 355 PIPENSP-ETEVALFRIRDRDSGENGKMICSIQ---DDVPFKLKP-SVENFYRLVTEGAL 409
Query: 755 DYESPRKKYELVIR---AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E+ R +Y + I +P L + + +LV+DVNDNAP ++ P
Sbjct: 410 DRET-RAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPAL 468
Query: 812 PFGRVPAYDAD--VTDKLQYRILSGNN-----ANLILLNETTGSMTLSPQLNTNVPKLAT 864
G V A D D ++ Y +L + +L+ +N G + L+ +
Sbjct: 469 HIGSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFE 528
Query: 865 MEVSVTD 871
V TD
Sbjct: 529 FRVGATD 535
Score = 134 bits (324), Expect = 4e-30
Identities = 130/482 (26%), Positives = 205/482 (42%), Gaps = 46/482 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND++P F YE V E + G+ V+ + A D D G N E+ Y++ + +
Sbjct: 230 ILVLDANDNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEID 289
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F + SG + LD E ++ Y + ++A+D L
Sbjct: 290 KP-----------------FELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGG-----L 327
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S ++ V ++D NDN+P+ S + T + E+ T+ +A + D D G N + +
Sbjct: 328 SGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETE---VALFRIRDRDSGENGKMICS 384
Query: 191 IIGGNTQMQFSID-SLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I + F + S+ LV LD E Y + I D G+P + + +
Sbjct: 385 I---QDDVPFKLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLV 441
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTGNVD 306
DVNDNAP F + + V EN I V A D D G NA++TY+ + +D +
Sbjct: 442 SDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPRDPHLPLT 501
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
++I+ +G ++ LD E ++ V ATD G P S+ A
Sbjct: 502 SLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFV 561
Query: 367 M-PGQY-EVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQN 418
+ P Q E P PG V + A D D L Y++ G F + + N
Sbjct: 562 LYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHN 621
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITD--ANNYAPVFENAPY 474
G + A+ L + ++ L V D+G RS TA +Q+ + D + Y P+ E AP
Sbjct: 622 GE--VRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVDGFSQPYLPLPEAAPA 679
Query: 475 TA 476
A
Sbjct: 680 QA 681
Score = 111 bits (267), Expect = 3e-23
Identities = 97/330 (29%), Positives = 150/330 (45%), Gaps = 24/330 (7%)
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
P SV E+ G+ V ++ +D+G+ + + +E ++Q ++ QTG
Sbjct: 30 PRRYSVMEETERGSFVANLA---NDLGLGVGELAERGARVVSE---DNEQGLQLDLQTGQ 83
Query: 533 ITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
+ N+ LDRE + G + + + E+ V D+ND+ P F ++ T I
Sbjct: 84 LILNEKLDREKLCGPTEPCIMHFQVLLKKPLEVFRAELLVTDINDHSPEFPEREMTLKIP 143
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKD------REEGSFVIDPASGVIRTNKAL 645
E + +GT A D DVG N +Y + P R G P V+ T L
Sbjct: 144 ETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPEL-VLDTE--L 200
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
DRE A L A+DGG+PP+S TV + I + D ND+ P F + ENSP+G+
Sbjct: 201 DREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVGSL 260
Query: 706 IGEIRAHDPDEGPNAVVHYSI--KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKY 763
+ ++ A D D G N + YS+ + F L + G E+ + LD+E+ Y
Sbjct: 261 VVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSG----EIRLIKKLDFET-MSSY 315
Query: 764 ELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
+L I A+ L V + V DVNDN P
Sbjct: 316 DLDIEASDGGGLSGKCSVSVKVLDVNDNFP 345
Score = 93.5 bits (222), Expect = 1e-17
Identities = 73/247 (29%), Positives = 113/247 (45%), Gaps = 23/247 (9%)
Query: 9 QQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
Q I VL D ND++P F Y VRE S + ++ ATD+D G NA+V Y++
Sbjct: 435 QSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL---- 490
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
L P D + + I+ +G L SLD E + + V ATD+ P
Sbjct: 491 ---LPPRDPHLP-------LTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPA 540
Query: 127 SDRLSSTATIHVNIIDDNDNYP--QFSEKTYTVSVDEDISVTDNP--VIAKIKATDADVG 182
LSS A + V ++D NDN P + + + E + P ++ K+ A D D G
Sbjct: 541 ---LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSG 597
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ F + + +G+V + L V +RLV+ +D G P RS T
Sbjct: 598 QNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATAT 657
Query: 243 LLINIRD 249
L + + D
Sbjct: 658 LQVLLVD 664
>BC113372-1|AAI13373.1| 792|Homo sapiens protocadherin alpha 12
protein.
Length = 792
Score = 220 bits (537), Expect = 7e-56
Identities = 171/614 (27%), Positives = 280/614 (45%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DREK+ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREKLCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI-IGGNTQMQFSID--- 203
P F E+ V V E + + + A+DAD+G NS + YA+ + N +++
Sbjct: 131 PVFREREQKVPVSESAPLDSHFPLEG--ASDADIGVNSLLTYALSLNENFELKIKTKKDK 188
Query: 204 SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
S+ ++ L K LD EQ L++ DGG P + + Q+ I + DVNDN P F ++
Sbjct: 189 SILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYK 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
+SENV ++++ A D DEG+N E++Y + + +I+P +G + G+
Sbjct: 249 VVLSENVQNDTRVIQLNASDPDEGLNGEISYGI-KMILPVSEKCMFSINPDTGEIRIYGE 307
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E Y++ V A D G P + + M + + ED GT
Sbjct: 308 LDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGT 367
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ ++ +D D + ++ +T + + T +N L+ + LD + Y L V
Sbjct: 368 VIALISVSDRDSGANGQVICSLT-PHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485
Query: 500 INAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + H +V ++ ++G + + LD E + V+ARD GV
Sbjct: 486 KNALVSYSL---VERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATDADVG 611
P L +++ V+D NDN P + +A LV G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELDPKD-REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P F + +G I T + LD H L + D G P +ST
Sbjct: 603 YNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTST 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVENGQAP 676
Score = 202 bits (493), Expect = 1e-50
Identities = 164/586 (27%), Positives = 270/586 (46%), Gaps = 52/586 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF ++ + V E A + A+D DIG N+ + Y +
Sbjct: 118 HVDVEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYAL----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+LN + L+ R LDRE+ + +L+ D P
Sbjct: 173 -SLNENFELKIKTKKDKSILP---------ELVLRKLLDREQTPKLNLLLMVIDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ + I + ++D NDN P F + +Y V + E++ D VI ++ A+D D G N I
Sbjct: 221 -ELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQ-NDTRVI-QLNASDPDEGLNGEI 277
Query: 188 RYA---IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y I+ + + FSI+ +G++ + LD+E+ +Y + + A D G PS + + +L
Sbjct: 278 SYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDN P + V E+ +G I + D D G N ++ ++T +
Sbjct: 338 VEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEI----TGGNTRGRF-SITS 416
F +Y V + E+ PPG + T++A DAD + N L Y + G + + S+ +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHA 512
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
++G+ + QPLD ++ VSA D+G +Q+ + D N+ AP P
Sbjct: 513 ESGK--VYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPA 570
Query: 475 TA---SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ +V E P G V V A D+D G NA ++Y E+ AV H F +
Sbjct: 571 GSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSY----ELQPAAVGAH-IPFHVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T ++LD + L V +D G P+L+ T V +S+V+
Sbjct: 626 LYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE 671
Score = 200 bits (488), Expect = 6e-50
Identities = 159/571 (27%), Positives = 254/571 (44%), Gaps = 38/571 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + VSE+ P+ A DAD GVN+ LTY ++ + N
Sbjct: 121 VEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNE---N 177
Query: 305 VDLPI-TIDPRS--GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+L I T +S + LDRE K LL+ DGG P + +
Sbjct: 178 FELKIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVND 237
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-------NTRGRFSI 414
F Y+V L+E+ T V+ L A+D DE L+ EI+ G + + FSI
Sbjct: 238 NGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEG--LNGEISYGIKMILPVSEKCMFSI 295
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENA 472
G I + LDF++ Y + V+A D G + +MV + + D N+ P
Sbjct: 296 NPDTGE--IRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVT 353
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
+ V EDA +GT + ++S +D D G N Q+ SL+ + + V+ + + +
Sbjct: 354 SLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYY-------S 406
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ + LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E
Sbjct: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKE 466
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRE 648
+ G + V A DAD N + Y L + + S+V + SG + + LD E
Sbjct: 467 NNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHE 526
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSP 701
+ + A D G PP S V + + + D ND+ P ++ + +
Sbjct: 527 ELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVG 586
Query: 702 IGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK 761
G + ++RA D D G NA + Y ++ + + ++D + ++PR
Sbjct: 587 AGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILD-EADAPRH 645
Query: 762 KYELVIRAASPPLWNDVRVEILVTDVNDNAP 792
+ ++++ P ++ N AP
Sbjct: 646 RLLVLVKDHGEPALTSTATVLVSLVENGQAP 676
Score = 180 bits (439), Expect = 5e-44
Identities = 128/438 (29%), Positives = 212/438 (48%), Gaps = 14/438 (3%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI- 423
F + +V ++E P + A+DAD N L N I ++ + ++
Sbjct: 133 FREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILP 192
Query: 424 --TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVF 479
+ + LD +Q + L + D G T VQI IT D N+ P F+ Y +
Sbjct: 193 ELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLS 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ T V+ ++A+D D G+N +I+Y + + F INP TG I L
Sbjct: 253 ENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP----VSEKCMFSINPDTGEIRIYGEL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + V A D G+PS++ + V + V+DVNDN P + + EDA VGT
Sbjct: 309 DFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTV 368
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 IALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVVTA 427
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D N
Sbjct: 428 RDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKN 487
Query: 720 AVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWN 776
A+V YS ++ ++ S ++ ++ + LD+E ++++ R A PPL +
Sbjct: 488 ALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 155 bits (376), Expect = 2e-36
Identities = 138/490 (28%), Positives = 211/490 (43%), Gaps = 40/490 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
QI VLD ND+ P F+ Y+ + E + T V+ L A+D D G N E+ Y I+++
Sbjct: 229 QITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP-- 286
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F I+ +G + LD E+ Y + V A D+ P
Sbjct: 287 --------------VSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIP---S 329
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + + V ++D NDN P+ + ++ V ED V VIA I +D D GAN +
Sbjct: 330 MAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQV--GTVIALISVSDRDSGANGQV-- 385
Query: 190 AIIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F + + SLV LD E V +Y LV+ A+DGGSPS T ++ +
Sbjct: 386 -ICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVE 444
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-V 305
+ DVNDNAP F + V EN P G I V A+DAD NA ++Y++ ++ + +
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHAL 504
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 366 FM---PGQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G ++E P G V + A DAD L YE+
Sbjct: 565 LLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHV 624
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
G I+ + LD R+ L V D G + TA V +++ + N AP +
Sbjct: 625 GLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE-NGQAPKTSSRAS 683
Query: 475 TASVFEDAPI 484
+V +A +
Sbjct: 684 VGAVDPEAAL 693
Score = 121 bits (292), Expect = 3e-26
Identities = 93/326 (28%), Positives = 145/326 (44%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV+E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVYEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V++ V D+NDN PVF+++ + E A
Sbjct: 88 SRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESAP 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR---TNKALDRESVAT 652
+ + GA+DAD+G+N + Y L + E ++ K LDRE
Sbjct: 148 LDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLLDREQTPK 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
+L + IDGG P + +V + I + D+ND+ P F+ +SEN T + ++ A
Sbjct: 208 LNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNAS 267
Query: 713 DPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPDEG N + Y IK + FS+ D E+ +LD+E YE+ + A
Sbjct: 268 DPDEGLNGEISYGIKMILPVSEKCMFSI----NPDTGEIRIYGELDFEE-NNAYEIQVNA 322
Query: 770 AS---PPLWNDVRVEILVTDVNDNAP 792
P + V + V DVNDN P
Sbjct: 323 IDKGIPSMAGHSMVLVEVLDVNDNVP 348
>BC112280-1|AAI12281.1| 792|Homo sapiens protocadherin alpha 12,
isoform 2 precursor protein.
Length = 792
Score = 220 bits (537), Expect = 7e-56
Identities = 171/614 (27%), Positives = 280/614 (45%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DREK+ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREKLCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI-IGGNTQMQFSID--- 203
P F E+ V V E + + + A+DAD+G NS + YA+ + N +++
Sbjct: 131 PVFREREQKVPVSESAPLDSHFPLEG--ASDADIGVNSLLTYALSLNENFELKIKTKKDK 188
Query: 204 SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
S+ ++ L K LD EQ L++ DGG P + + Q+ I + DVNDN P F ++
Sbjct: 189 SILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYK 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
+SENV ++++ A D DEG+N E++Y + + +I+P +G + G+
Sbjct: 249 VVLSENVQNDTRVIQLNASDPDEGLNGEISYGI-KMILPVSEKCMFSINPDTGEIRIYGE 307
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E Y++ V A D G P + + M + + ED GT
Sbjct: 308 LDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGT 367
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ ++ +D D + ++ +T + + T +N L+ + LD + Y L V
Sbjct: 368 VIALISVSDRDSGANGQVICSLT-PHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485
Query: 500 INAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + H +V ++ ++G + + LD E + V+ARD GV
Sbjct: 486 KNALVSYSL---VERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATDADVG 611
P L +++ V+D NDN P + +A LV G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELDPKD-REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P F + +G I T + LD H L + D G P +ST
Sbjct: 603 YNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTST 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVENGQAP 676
Score = 202 bits (493), Expect = 1e-50
Identities = 164/586 (27%), Positives = 270/586 (46%), Gaps = 52/586 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF ++ + V E A + A+D DIG N+ + Y +
Sbjct: 118 HVDVEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYAL----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+LN + L+ R LDRE+ + +L+ D P
Sbjct: 173 -SLNENFELKIKTKKDKSILP---------ELVLRKLLDREQTPKLNLLLMVIDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ + I + ++D NDN P F + +Y V + E++ D VI ++ A+D D G N I
Sbjct: 221 -ELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQ-NDTRVI-QLNASDPDEGLNGEI 277
Query: 188 RYA---IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y I+ + + FSI+ +G++ + LD+E+ +Y + + A D G PS + + +L
Sbjct: 278 SYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDN P + V E+ +G I + D D G N ++ ++T +
Sbjct: 338 VEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEI----TGGNTRGRF-SITS 416
F +Y V + E+ PPG + T++A DAD + N L Y + G + + S+ +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHA 512
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
++G+ + QPLD ++ VSA D+G +Q+ + D N+ AP P
Sbjct: 513 ESGK--VYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPA 570
Query: 475 TA---SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ +V E P G V V A D+D G NA ++Y E+ AV H F +
Sbjct: 571 GSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSY----ELQPAAVGAH-IPFHVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T ++LD + L V +D G P+L+ T V +S+V+
Sbjct: 626 LYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE 671
Score = 200 bits (488), Expect = 6e-50
Identities = 159/571 (27%), Positives = 254/571 (44%), Gaps = 38/571 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + VSE+ P+ A DAD GVN+ LTY ++ + N
Sbjct: 121 VEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNE---N 177
Query: 305 VDLPI-TIDPRS--GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+L I T +S + LDRE K LL+ DGG P + +
Sbjct: 178 FELKIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVND 237
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-------NTRGRFSI 414
F Y+V L+E+ T V+ L A+D DE L+ EI+ G + + FSI
Sbjct: 238 NGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEG--LNGEISYGIKMILPVSEKCMFSI 295
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENA 472
G I + LDF++ Y + V+A D G + +MV + + D N+ P
Sbjct: 296 NPDTGE--IRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVT 353
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
+ V EDA +GT + ++S +D D G N Q+ SL+ + + V+ + + +
Sbjct: 354 SLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYY-------S 406
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ + LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E
Sbjct: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKE 466
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRE 648
+ G + V A DAD N + Y L + + S+V + SG + + LD E
Sbjct: 467 NNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHE 526
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSP 701
+ + A D G PP S V + + + D ND+ P ++ + +
Sbjct: 527 ELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVG 586
Query: 702 IGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK 761
G + ++RA D D G NA + Y ++ + + ++D + ++PR
Sbjct: 587 AGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILD-EADAPRH 645
Query: 762 KYELVIRAASPPLWNDVRVEILVTDVNDNAP 792
+ ++++ P ++ N AP
Sbjct: 646 RLLVLVKDHGEPALTSTATVLVSLVENGQAP 676
Score = 180 bits (439), Expect = 5e-44
Identities = 128/438 (29%), Positives = 212/438 (48%), Gaps = 14/438 (3%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI- 423
F + +V ++E P + A+DAD N L N I ++ + ++
Sbjct: 133 FREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILP 192
Query: 424 --TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVF 479
+ + LD +Q + L + D G T VQI IT D N+ P F+ Y +
Sbjct: 193 ELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLS 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ T V+ ++A+D D G+N +I+Y + + F INP TG I L
Sbjct: 253 ENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP----VSEKCMFSINPDTGEIRIYGEL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + V A D G+PS++ + V + V+DVNDN P + + EDA VGT
Sbjct: 309 DFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTV 368
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 IALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVVTA 427
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D N
Sbjct: 428 RDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKN 487
Query: 720 AVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWN 776
A+V YS ++ ++ S ++ ++ + LD+E ++++ R A PPL +
Sbjct: 488 ALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 155 bits (376), Expect = 2e-36
Identities = 138/490 (28%), Positives = 211/490 (43%), Gaps = 40/490 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
QI VLD ND+ P F+ Y+ + E + T V+ L A+D D G N E+ Y I+++
Sbjct: 229 QITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP-- 286
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F I+ +G + LD E+ Y + V A D+ P
Sbjct: 287 --------------VSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIP---S 329
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + + V ++D NDN P+ + ++ V ED V VIA I +D D GAN +
Sbjct: 330 MAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQV--GTVIALISVSDRDSGANGQV-- 385
Query: 190 AIIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F + + SLV LD E V +Y LV+ A+DGGSPS T ++ +
Sbjct: 386 -ICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVE 444
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-V 305
+ DVNDNAP F + V EN P G I V A+DAD NA ++Y++ ++ + +
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHAL 504
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 366 FM---PGQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G ++E P G V + A DAD L YE+
Sbjct: 565 LLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHV 624
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
G I+ + LD R+ L V D G + TA V +++ + N AP +
Sbjct: 625 GLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE-NGQAPKTSSRAS 683
Query: 475 TASVFEDAPI 484
+V +A +
Sbjct: 684 VGAVDPEAAL 693
Score = 121 bits (292), Expect = 3e-26
Identities = 93/326 (28%), Positives = 145/326 (44%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV+E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVYEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V++ V D+NDN PVF+++ + E A
Sbjct: 88 SRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESAP 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR---TNKALDRESVAT 652
+ + GA+DAD+G+N + Y L + E ++ K LDRE
Sbjct: 148 LDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLLDREQTPK 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
+L + IDGG P + +V + I + D+ND+ P F+ +SEN T + ++ A
Sbjct: 208 LNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNAS 267
Query: 713 DPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPDEG N + Y IK + FS+ D E+ +LD+E YE+ + A
Sbjct: 268 DPDEGLNGEISYGIKMILPVSEKCMFSI----NPDTGEIRIYGELDFEE-NNAYEIQVNA 322
Query: 770 AS---PPLWNDVRVEILVTDVNDNAP 792
P + V + V DVNDN P
Sbjct: 323 IDKGIPSMAGHSMVLVEVLDVNDNVP 348
>AF152477-1|AAD43738.1| 792|Homo sapiens protocadherin alpha 12
short form protein protein.
Length = 792
Score = 220 bits (537), Expect = 7e-56
Identities = 171/614 (27%), Positives = 280/614 (45%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DREK+ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREKLCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI-IGGNTQMQFSID--- 203
P F E+ V V E + + + A+DAD+G NS + YA+ + N +++
Sbjct: 131 PVFREREQKVPVSESAPLDSHFPLEG--ASDADIGVNSLLTYALSLNENFELKIKTKKDK 188
Query: 204 SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
S+ ++ L K LD EQ L++ DGG P + + Q+ I + DVNDN P F ++
Sbjct: 189 SILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYK 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
+SENV ++++ A D DEG+N E++Y + + +I+P +G + G+
Sbjct: 249 VVLSENVQNDTRVIQLNASDPDEGLNGEISYGI-KMILPVSEKCMFSINPDTGEIRIYGE 307
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E Y++ V A D G P + + M + + ED GT
Sbjct: 308 LDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGT 367
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ ++ +D D + ++ +T + + T +N L+ + LD + Y L V
Sbjct: 368 VIALISVSDRDSGANGQVICSLT-PHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485
Query: 500 INAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + H +V ++ ++G + + LD E + V+ARD GV
Sbjct: 486 KNALVSYSL---VERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATDADVG 611
P L +++ V+D NDN P + +A LV G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELDPKD-REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P F + +G I T + LD H L + D G P +ST
Sbjct: 603 YNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTST 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVENGQAP 676
Score = 202 bits (493), Expect = 1e-50
Identities = 164/586 (27%), Positives = 270/586 (46%), Gaps = 52/586 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF ++ + V E A + A+D DIG N+ + Y +
Sbjct: 118 HVDVEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYAL----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+LN + L+ R LDRE+ + +L+ D P
Sbjct: 173 -SLNENFELKIKTKKDKSILP---------ELVLRKLLDREQTPKLNLLLMVIDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ + I + ++D NDN P F + +Y V + E++ D VI ++ A+D D G N I
Sbjct: 221 -ELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQ-NDTRVI-QLNASDPDEGLNGEI 277
Query: 188 RYA---IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y I+ + + FSI+ +G++ + LD+E+ +Y + + A D G PS + + +L
Sbjct: 278 SYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDN P + V E+ +G I + D D G N ++ ++T +
Sbjct: 338 VEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEI----TGGNTRGRF-SITS 416
F +Y V + E+ PPG + T++A DAD + N L Y + G + + S+ +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHA 512
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
++G+ + QPLD ++ VSA D+G +Q+ + D N+ AP P
Sbjct: 513 ESGK--VYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPA 570
Query: 475 TA---SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ +V E P G V V A D+D G NA ++Y E+ AV H F +
Sbjct: 571 GSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSY----ELQPAAVGAH-IPFHVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T ++LD + L V +D G P+L+ T V +S+V+
Sbjct: 626 LYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE 671
Score = 200 bits (488), Expect = 6e-50
Identities = 159/571 (27%), Positives = 254/571 (44%), Gaps = 38/571 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + VSE+ P+ A DAD GVN+ LTY ++ + N
Sbjct: 121 VEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNE---N 177
Query: 305 VDLPI-TIDPRS--GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+L I T +S + LDRE K LL+ DGG P + +
Sbjct: 178 FELKIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVND 237
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-------NTRGRFSI 414
F Y+V L+E+ T V+ L A+D DE L+ EI+ G + + FSI
Sbjct: 238 NGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEG--LNGEISYGIKMILPVSEKCMFSI 295
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENA 472
G I + LDF++ Y + V+A D G + +MV + + D N+ P
Sbjct: 296 NPDTGE--IRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVT 353
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
+ V EDA +GT + ++S +D D G N Q+ SL+ + + V+ + + +
Sbjct: 354 SLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYY-------S 406
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ + LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E
Sbjct: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKE 466
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRE 648
+ G + V A DAD N + Y L + + S+V + SG + + LD E
Sbjct: 467 NNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHE 526
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSP 701
+ + A D G PP S V + + + D ND+ P ++ + +
Sbjct: 527 ELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVG 586
Query: 702 IGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK 761
G + ++RA D D G NA + Y ++ + + ++D + ++PR
Sbjct: 587 AGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILD-EADAPRH 645
Query: 762 KYELVIRAASPPLWNDVRVEILVTDVNDNAP 792
+ ++++ P ++ N AP
Sbjct: 646 RLLVLVKDHGEPALTSTATVLVSLVENGQAP 676
Score = 180 bits (439), Expect = 5e-44
Identities = 128/438 (29%), Positives = 212/438 (48%), Gaps = 14/438 (3%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI- 423
F + +V ++E P + A+DAD N L N I ++ + ++
Sbjct: 133 FREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILP 192
Query: 424 --TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVF 479
+ + LD +Q + L + D G T VQI IT D N+ P F+ Y +
Sbjct: 193 ELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLS 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ T V+ ++A+D D G+N +I+Y + + F INP TG I L
Sbjct: 253 ENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP----VSEKCMFSINPDTGEIRIYGEL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + V A D G+PS++ + V + V+DVNDN P + + EDA VGT
Sbjct: 309 DFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTV 368
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 IALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVVTA 427
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D N
Sbjct: 428 RDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKN 487
Query: 720 AVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWN 776
A+V YS ++ ++ S ++ ++ + LD+E ++++ R A PPL +
Sbjct: 488 ALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 155 bits (376), Expect = 2e-36
Identities = 138/490 (28%), Positives = 211/490 (43%), Gaps = 40/490 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
QI VLD ND+ P F+ Y+ + E + T V+ L A+D D G N E+ Y I+++
Sbjct: 229 QITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP-- 286
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F I+ +G + LD E+ Y + V A D+ P
Sbjct: 287 --------------VSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIP---S 329
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + + V ++D NDN P+ + ++ V ED V VIA I +D D GAN +
Sbjct: 330 MAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQV--GTVIALISVSDRDSGANGQV-- 385
Query: 190 AIIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F + + SLV LD E V +Y LV+ A+DGGSPS T ++ +
Sbjct: 386 -ICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVE 444
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-V 305
+ DVNDNAP F + V EN P G I V A+DAD NA ++Y++ ++ + +
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHAL 504
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 366 FM---PGQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G ++E P G V + A DAD L YE+
Sbjct: 565 LLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHV 624
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
G I+ + LD R+ L V D G + TA V +++ + N AP +
Sbjct: 625 GLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE-NGQAPKTSSRAS 683
Query: 475 TASVFEDAPI 484
+V +A +
Sbjct: 684 VGAVDPEAAL 693
Score = 121 bits (292), Expect = 3e-26
Identities = 93/326 (28%), Positives = 145/326 (44%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV+E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVYEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V++ V D+NDN PVF+++ + E A
Sbjct: 88 SRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESAP 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR---TNKALDRESVAT 652
+ + GA+DAD+G+N + Y L + E ++ K LDRE
Sbjct: 148 LDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLLDREQTPK 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
+L + IDGG P + +V + I + D+ND+ P F+ +SEN T + ++ A
Sbjct: 208 LNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNAS 267
Query: 713 DPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPDEG N + Y IK + FS+ D E+ +LD+E YE+ + A
Sbjct: 268 DPDEGLNGEISYGIKMILPVSEKCMFSI----NPDTGEIRIYGELDFEE-NNAYEIQVNA 322
Query: 770 AS---PPLWNDVRVEILVTDVNDNAP 792
P + V + V DVNDN P
Sbjct: 323 IDKGIPSMAGHSMVLVEVLDVNDNVP 348
>AF152308-1|AAD43702.1| 941|Homo sapiens protocadherin alpha 12
protein.
Length = 941
Score = 220 bits (537), Expect = 7e-56
Identities = 171/614 (27%), Positives = 280/614 (45%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DREK+ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREKLCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI-IGGNTQMQFSID--- 203
P F E+ V V E + + + A+DAD+G NS + YA+ + N +++
Sbjct: 131 PVFREREQKVPVSESAPLDSHFPLEG--ASDADIGVNSLLTYALSLNENFELKIKTKKDK 188
Query: 204 SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
S+ ++ L K LD EQ L++ DGG P + + Q+ I + DVNDN P F ++
Sbjct: 189 SILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYK 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
+SENV ++++ A D DEG+N E++Y + + +I+P +G + G+
Sbjct: 249 VVLSENVQNDTRVIQLNASDPDEGLNGEISYGI-KMILPVSEKCMFSINPDTGEIRIYGE 307
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E Y++ V A D G P + + M + + ED GT
Sbjct: 308 LDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGT 367
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ ++ +D D + ++ +T + + T +N L+ + LD + Y L V
Sbjct: 368 VIALISVSDRDSGANGQVICSLT-PHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485
Query: 500 INAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + H +V ++ ++G + + LD E + V+ARD GV
Sbjct: 486 KNALVSYSL---VERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATDADVG 611
P L +++ V+D NDN P + +A LV G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELDPKD-REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P F + +G I T + LD H L + D G P +ST
Sbjct: 603 YNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTST 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVENGQAP 676
Score = 202 bits (493), Expect = 1e-50
Identities = 164/586 (27%), Positives = 270/586 (46%), Gaps = 52/586 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF ++ + V E A + A+D DIG N+ + Y +
Sbjct: 118 HVDVEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYAL----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+LN + L+ R LDRE+ + +L+ D P
Sbjct: 173 -SLNENFELKIKTKKDKSILP---------ELVLRKLLDREQTPKLNLLLMVIDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ + I + ++D NDN P F + +Y V + E++ D VI ++ A+D D G N I
Sbjct: 221 -ELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQ-NDTRVI-QLNASDPDEGLNGEI 277
Query: 188 RYA---IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y I+ + + FSI+ +G++ + LD+E+ +Y + + A D G PS + + +L
Sbjct: 278 SYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDN P + V E+ +G I + D D G N ++ ++T +
Sbjct: 338 VEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEI----TGGNTRGRF-SITS 416
F +Y V + E+ PPG + T++A DAD + N L Y + G + + S+ +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHA 512
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
++G+ + QPLD ++ VSA D+G +Q+ + D N+ AP P
Sbjct: 513 ESGK--VYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPA 570
Query: 475 TA---SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ +V E P G V V A D+D G NA ++Y E+ AV H F +
Sbjct: 571 GSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSY----ELQPAAVGAH-IPFHVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T ++LD + L V +D G P+L+ T V +S+V+
Sbjct: 626 LYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE 671
Score = 200 bits (488), Expect = 6e-50
Identities = 159/571 (27%), Positives = 254/571 (44%), Gaps = 38/571 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + VSE+ P+ A DAD GVN+ LTY ++ + N
Sbjct: 121 VEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNE---N 177
Query: 305 VDLPI-TIDPRS--GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+L I T +S + LDRE K LL+ DGG P + +
Sbjct: 178 FELKIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVND 237
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-------NTRGRFSI 414
F Y+V L+E+ T V+ L A+D DE L+ EI+ G + + FSI
Sbjct: 238 NGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEG--LNGEISYGIKMILPVSEKCMFSI 295
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENA 472
G I + LDF++ Y + V+A D G + +MV + + D N+ P
Sbjct: 296 NPDTGE--IRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVT 353
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
+ V EDA +GT + ++S +D D G N Q+ SL+ + + V+ + + +
Sbjct: 354 SLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYY-------S 406
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ + LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E
Sbjct: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKE 466
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRE 648
+ G + V A DAD N + Y L + + S+V + SG + + LD E
Sbjct: 467 NNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHE 526
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSP 701
+ + A D G PP S V + + + D ND+ P ++ + +
Sbjct: 527 ELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVG 586
Query: 702 IGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK 761
G + ++RA D D G NA + Y ++ + + ++D + ++PR
Sbjct: 587 AGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILD-EADAPRH 645
Query: 762 KYELVIRAASPPLWNDVRVEILVTDVNDNAP 792
+ ++++ P ++ N AP
Sbjct: 646 RLLVLVKDHGEPALTSTATVLVSLVENGQAP 676
Score = 180 bits (439), Expect = 5e-44
Identities = 128/438 (29%), Positives = 212/438 (48%), Gaps = 14/438 (3%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI- 423
F + +V ++E P + A+DAD N L N I ++ + ++
Sbjct: 133 FREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILP 192
Query: 424 --TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVF 479
+ + LD +Q + L + D G T VQI IT D N+ P F+ Y +
Sbjct: 193 ELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLS 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ T V+ ++A+D D G+N +I+Y + + F INP TG I L
Sbjct: 253 ENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP----VSEKCMFSINPDTGEIRIYGEL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + V A D G+PS++ + V + V+DVNDN P + + EDA VGT
Sbjct: 309 DFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTV 368
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 IALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVVTA 427
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D N
Sbjct: 428 RDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKN 487
Query: 720 AVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWN 776
A+V YS ++ ++ S ++ ++ + LD+E ++++ R A PPL +
Sbjct: 488 ALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 155 bits (376), Expect = 2e-36
Identities = 138/490 (28%), Positives = 211/490 (43%), Gaps = 40/490 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
QI VLD ND+ P F+ Y+ + E + T V+ L A+D D G N E+ Y I+++
Sbjct: 229 QITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP-- 286
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F I+ +G + LD E+ Y + V A D+ P
Sbjct: 287 --------------VSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIP---S 329
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + + V ++D NDN P+ + ++ V ED V VIA I +D D GAN +
Sbjct: 330 MAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQV--GTVIALISVSDRDSGANGQV-- 385
Query: 190 AIIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F + + SLV LD E V +Y LV+ A+DGGSPS T ++ +
Sbjct: 386 -ICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVE 444
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-V 305
+ DVNDNAP F + V EN P G I V A+DAD NA ++Y++ ++ + +
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHAL 504
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 366 FM---PGQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G ++E P G V + A DAD L YE+
Sbjct: 565 LLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHV 624
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
G I+ + LD R+ L V D G + TA V +++ + N AP +
Sbjct: 625 GLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE-NGQAPKTSSRAS 683
Query: 475 TASVFEDAPI 484
+V +A +
Sbjct: 684 VGAVDPEAAL 693
Score = 121 bits (292), Expect = 3e-26
Identities = 93/326 (28%), Positives = 145/326 (44%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV+E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVYEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V++ V D+NDN PVF+++ + E A
Sbjct: 88 SRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESAP 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR---TNKALDRESVAT 652
+ + GA+DAD+G+N + Y L + E ++ K LDRE
Sbjct: 148 LDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLLDREQTPK 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
+L + IDGG P + +V + I + D+ND+ P F+ +SEN T + ++ A
Sbjct: 208 LNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNAS 267
Query: 713 DPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPDEG N + Y IK + FS+ D E+ +LD+E YE+ + A
Sbjct: 268 DPDEGLNGEISYGIKMILPVSEKCMFSI----NPDTGEIRIYGELDFEE-NNAYEIQVNA 322
Query: 770 AS---PPLWNDVRVEILVTDVNDNAP 792
P + V + V DVNDN P
Sbjct: 323 IDKGIPSMAGHSMVLVEVLDVNDNVP 348
>AC005609-2|AAC34315.1| 792|Homo sapiens KIAA0345-like 2 protein.
Length = 792
Score = 220 bits (537), Expect = 7e-56
Identities = 171/614 (27%), Positives = 280/614 (45%), Gaps = 27/614 (4%)
Query: 88 DVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNY 147
D+ ++ ++G L + +DREK+ + + + + DR + V + D NDN
Sbjct: 73 DLLEVNLQNGILFVNSRIDREKLCGRSA--ECSIHLEVIVDRPLQVFHVDVEVKDINDNP 130
Query: 148 PQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAI-IGGNTQMQFSID--- 203
P F E+ V V E + + + A+DAD+G NS + YA+ + N +++
Sbjct: 131 PVFREREQKVPVSESAPLDSHFPLEG--ASDADIGVNSLLTYALSLNENFELKIKTKKDK 188
Query: 204 SLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
S+ ++ L K LD EQ L++ DGG P + + Q+ I + DVNDN P F ++
Sbjct: 189 SILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYK 248
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
+SENV ++++ A D DEG+N E++Y + + +I+P +G + G+
Sbjct: 249 VVLSENVQNDTRVIQLNASDPDEGLNGEISYGI-KMILPVSEKCMFSINPDTGEIRIYGE 307
Query: 324 LDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGT 383
LD E Y++ V A D G P + + M + + ED GT
Sbjct: 308 LDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGT 367
Query: 384 PVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV 441
+ ++ +D D + ++ +T + + T +N L+ + LD + Y L V
Sbjct: 368 VIALISVSDRDSGANGQVICSLT-PHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVV 425
Query: 442 SATDSGGRS--DTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
+A D G S TA V + + D N+ AP F YT V E+ P G + VSA D+D
Sbjct: 426 TARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQ 485
Query: 500 INAQITYSLSSEISNEAVAHHDQQFV-INPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NA ++YSL + H +V ++ ++G + + LD E + V+ARD GV
Sbjct: 486 KNALVSYSL---VERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGV 542
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALV------GTSVSQVGATDADVG 611
P L +++ V+D NDN P + +A LV G V++V A DAD G
Sbjct: 543 PPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSG 602
Query: 612 LNGRIHYELDPKD-REEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSST 670
N + YEL P F + +G I T + LD H L + D G P +ST
Sbjct: 603 YNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTST 662
Query: 671 VIVHIKIEDINDSP 684
V + + + +P
Sbjct: 663 ATVLVSLVENGQAP 676
Score = 202 bits (493), Expect = 1e-50
Identities = 164/586 (27%), Positives = 270/586 (46%), Gaps = 52/586 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+ PVF ++ + V E A + A+D DIG N+ + Y +
Sbjct: 118 HVDVEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYAL----- 172
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
+LN + L+ R LDRE+ + +L+ D P
Sbjct: 173 -SLNENFELKIKTKKDKSILP---------ELVLRKLLDREQTPKLNLLLMVIDGGKP-- 220
Query: 128 DRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAI 187
L+ + I + ++D NDN P F + +Y V + E++ D VI ++ A+D D G N I
Sbjct: 221 -ELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQ-NDTRVI-QLNASDPDEGLNGEI 277
Query: 188 RYA---IIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLL 244
Y I+ + + FSI+ +G++ + LD+E+ +Y + + A D G PS + + +L
Sbjct: 278 SYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVL 337
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ + DVNDN P + V E+ +G I + D D G N ++ ++T +
Sbjct: 338 VEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTP-----H 392
Query: 305 VDLPITIDPRSGW-VYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
V + ++ + + LDRE+ + Y+L+VTA DGG P ATA
Sbjct: 393 VPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNA 452
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD-EDNRL-HYEI----TGGNTRGRF-SITS 416
F +Y V + E+ PPG + T++A DAD + N L Y + G + + S+ +
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHA 512
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
++G+ + QPLD ++ VSA D+G +Q+ + D N+ AP P
Sbjct: 513 ESGK--VYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPA 570
Query: 475 TA---SVFEDAP----IGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVIN 527
+ +V E P G V V A D+D G NA ++Y E+ AV H F +
Sbjct: 571 GSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSY----ELQPAAVGAH-IPFHVG 625
Query: 528 PQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG I+T ++LD + L V +D G P+L+ T V +S+V+
Sbjct: 626 LYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE 671
Score = 200 bits (488), Expect = 6e-50
Identities = 159/571 (27%), Positives = 254/571 (44%), Gaps = 38/571 (6%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ ++D+NDN P F + VSE+ P+ A DAD GVN+ LTY ++ + N
Sbjct: 121 VEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNE---N 177
Query: 305 VDLPI-TIDPRS--GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXX 361
+L I T +S + LDRE K LL+ DGG P + +
Sbjct: 178 FELKIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVND 237
Query: 362 XXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEITGG-------NTRGRFSI 414
F Y+V L+E+ T V+ L A+D DE L+ EI+ G + + FSI
Sbjct: 238 NGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEG--LNGEISYGIKMILPVSEKCMFSI 295
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENA 472
G I + LDF++ Y + V+A D G + +MV + + D N+ P
Sbjct: 296 NPDTGE--IRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVT 353
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
+ V EDA +GT + ++S +D D G N Q+ SL+ + + V+ + + +
Sbjct: 354 SLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYY-------S 406
Query: 533 ITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIME 592
+ + LDRE++S Y L VTARDGG PSL T V + V DVNDN P F Q YT + E
Sbjct: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKE 466
Query: 593 DALVGTSVSQVGATDADVGLNGRIHYELDPK---DREEGSFV-IDPASGVIRTNKALDRE 648
+ G + V A DAD N + Y L + + S+V + SG + + LD E
Sbjct: 467 NNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHE 526
Query: 649 SVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVF-------ESDCLTFYISENSP 701
+ + A D G PP S V + + + D ND+ P ++ + +
Sbjct: 527 ELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVG 586
Query: 702 IGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK 761
G + ++RA D D G NA + Y ++ + + ++D + ++PR
Sbjct: 587 AGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILD-EADAPRH 645
Query: 762 KYELVIRAASPPLWNDVRVEILVTDVNDNAP 792
+ ++++ P ++ N AP
Sbjct: 646 RLLVLVKDHGEPALTSTATVLVSLVENGQAP 676
Score = 180 bits (439), Expect = 5e-44
Identities = 128/438 (29%), Positives = 212/438 (48%), Gaps = 14/438 (3%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLHYEITGGNTRGRFSITSQNGRGLI- 423
F + +V ++E P + A+DAD N L N I ++ + ++
Sbjct: 133 FREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILP 192
Query: 424 --TVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVF 479
+ + LD +Q + L + D G T VQI IT D N+ P F+ Y +
Sbjct: 193 ELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLS 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E+ T V+ ++A+D D G+N +I+Y + + F INP TG I L
Sbjct: 253 ENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP----VSEKCMFSINPDTGEIRIYGEL 308
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D E + Y + V A D G+PS++ + V + V+DVNDN P + + EDA VGT
Sbjct: 309 DFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTV 368
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVA 659
++ + +D D G NG++ L P + ++ + ALDRESV+ ++L A
Sbjct: 369 IALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLV-LDSALDRESVSAYELVVTA 427
Query: 660 IDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPN 719
DGG+P +T V +++ D+ND+ P F T ++ EN+P G I + A D D N
Sbjct: 428 RDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKN 487
Query: 720 AVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIRAAS-PPLWN 776
A+V YS ++ ++ S ++ ++ + LD+E ++++ R A PPL +
Sbjct: 488 ALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGS 547
Query: 777 DVRVEILVTDVNDNAPVM 794
+V +++ V D NDNAP +
Sbjct: 548 NVTLQVFVLDENDNAPAL 565
Score = 155 bits (376), Expect = 2e-36
Identities = 138/490 (28%), Positives = 211/490 (43%), Gaps = 40/490 (8%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
QI VLD ND+ P F+ Y+ + E + T V+ L A+D D G N E+ Y I+++
Sbjct: 229 QITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILP-- 286
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDR 129
+ +F I+ +G + LD E+ Y + V A D+ P
Sbjct: 287 --------------VSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIP---S 329
Query: 130 LSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRY 189
++ + + V ++D NDN P+ + ++ V ED V VIA I +D D GAN +
Sbjct: 330 MAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQV--GTVIALISVSDRDSGANGQV-- 385
Query: 190 AIIGGNTQMQFS-IDSLSGDVSLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
I + F + + SLV LD E V +Y LV+ A+DGGSPS T ++ +
Sbjct: 386 -ICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVE 444
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN-V 305
+ DVNDNAP F + V EN P G I V A+DAD NA ++Y++ ++ + +
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHAL 504
Query: 306 DLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
+++ SG VY LD E Q V+A D G PP + T
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 366 FM---PGQYEVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITS 416
+ G ++E P G V + A DAD L YE+
Sbjct: 565 LLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHV 624
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPY 474
G I+ + LD R+ L V D G + TA V +++ + N AP +
Sbjct: 625 GLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE-NGQAPKTSSRAS 683
Query: 475 TASVFEDAPI 484
+V +A +
Sbjct: 684 VGAVDPEAAL 693
Score = 121 bits (292), Expect = 3e-26
Identities = 93/326 (28%), Positives = 145/326 (44%), Gaps = 21/326 (6%)
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
SV+E+A GT V ++ D+G+ L + A H +N Q G + N
Sbjct: 34 SVYEEAKHGTFVGRIA---QDLGLELA---ELVPRLFRVASKRHGDLLEVNLQNGILFVN 87
Query: 537 KLLDRETMSGYLLTVTAR-DGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDAL 595
+DRE + G + + V V++ V D+NDN PVF+++ + E A
Sbjct: 88 SRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESAP 147
Query: 596 VGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIR---TNKALDRESVAT 652
+ + GA+DAD+G+N + Y L + E ++ K LDRE
Sbjct: 148 LDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLLDREQTPK 207
Query: 653 HDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAH 712
+L + IDGG P + +V + I + D+ND+ P F+ +SEN T + ++ A
Sbjct: 208 LNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNAS 267
Query: 713 DPDEGPNAVVHYSIK---GGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA 769
DPDEG N + Y IK + FS+ D E+ +LD+E YE+ + A
Sbjct: 268 DPDEGLNGEISYGIKMILPVSEKCMFSI----NPDTGEIRIYGELDFEE-NNAYEIQVNA 322
Query: 770 AS---PPLWNDVRVEILVTDVNDNAP 792
P + V + V DVNDN P
Sbjct: 323 IDKGIPSMAGHSMVLVEVLDVNDNVP 348
>AB160984-1|BAD08246.1| 1123|Homo sapiens KIAA0811 protein protein.
Length = 1123
Score = 219 bits (536), Expect = 9e-56
Identities = 143/445 (32%), Positives = 215/445 (48%), Gaps = 20/445 (4%)
Query: 285 DEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDP 344
D+G NA++ Y++ D + + +ID +G + L QA +L V A+D G P
Sbjct: 1 DQGANAQVVYSLPD-----SAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTP 55
Query: 345 -PRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADEDNRLHYEI 403
P S T F+ ++ V++ ED PPGT V+ L + Y +
Sbjct: 56 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRV 115
Query: 404 TGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTV--SATDSGGRSDTAMVQINITD 461
GN +GRF + ++ G++ V LDF+ +Y L++ S S SD V +NITD
Sbjct: 116 VSGNEQGRFRLDART--GILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITD 173
Query: 462 ANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHD 521
N + P F PY+ V E+A +G +L VSATD D +N+ ITYSL I + H
Sbjct: 174 VNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSL---IGGNQLGH-- 228
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVF 581
F I+P+ G + K LDRE S Y L + A D G P L + TD+ I V DVNDN P F
Sbjct: 229 --FTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF 286
Query: 582 KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRT 641
Q Y+ + E++ +G+ V Q+ +D D NG + K +F + P G + T
Sbjct: 287 FQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVT 345
Query: 642 NKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSP 701
+ L R + + L+ A D G PP SS VH+ + + + P + + E+
Sbjct: 346 AEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVHVHVTEQSHYAPSALPLEIFITVGEDEF 405
Query: 702 IGTTIGEIRAHDPDEGPNAVVHYSI 726
G +G+I A D D P + YS+
Sbjct: 406 QGGMVGKIHATDRD--PQDTLTYSL 428
Score = 187 bits (456), Expect = 4e-46
Identities = 127/374 (33%), Positives = 184/374 (49%), Gaps = 16/374 (4%)
Query: 87 QDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDN 146
Q FR+D R+G L ASLD E +Y + ++ + ++S LS T+ VNI D N++
Sbjct: 121 QGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSS---SSLSDVTTVMVNITDVNEH 177
Query: 147 YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS 206
PQF + Y+ V E+ V D VI + ATD D NS I Y++IGGN F+I
Sbjct: 178 RPQFPQDPYSTRVLENALVGD--VILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKK 235
Query: 207 GDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESV 266
G++ + K LD EQ SY L +RA D G P T + I + DVNDN PRF+ + +V
Sbjct: 236 GELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTV 295
Query: 267 SENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDR 326
EN PIG ++++ D D N Y+ + GN + P GW+ T+ L R
Sbjct: 296 QENSPIGSKVLQLILSDPDSPENGP-PYSF--RITKGNNGSAFRVTP-DGWLVTAEGLSR 351
Query: 327 ETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVV 386
Q YQL + A+D G PP S+ + +P + + + EDE G V
Sbjct: 352 RAQEWYQLQIQASDSGIPPLSSLTSVHVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVG 411
Query: 387 TLTATDADEDNRLHYEITGGNTRGR-FSITSQNGRGLITVAQPLDFKQERRYVLTVSATD 445
+ ATD D + L Y + T GR FS+ + +G+ I AQ L Y V+ +D
Sbjct: 412 KIHATDRDPQDTLTYSLAEEETLGRHFSVGAPDGK--IIAAQGL---PRGHYSFNVTVSD 466
Query: 446 SGGRSDTAMVQINI 459
G + TA V + +
Sbjct: 467 -GTFTTTAGVHVYV 479
Score = 166 bits (404), Expect = 9e-40
Identities = 134/472 (28%), Positives = 210/472 (44%), Gaps = 29/472 (6%)
Query: 90 FRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQ 149
F ID +G + L A + V+A+D +P+ LS+ T+ V+++ D P
Sbjct: 20 FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIP--LSTLGTVTVSVVGLEDYLPV 77
Query: 150 FSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSGDV 209
F ++V V ED + ++ AT GA Y ++ GN Q +F +D+ +G +
Sbjct: 78 FLNTEHSVQVPED--APPGTEVLQL-ATLTRPGAEKT-GYRVVSGNEQGRFRLDARTGIL 133
Query: 210 SLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSEN 269
+ +LD+E Y L I S S S+ T +++NI DVN++ P+F + V EN
Sbjct: 134 YVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLEN 193
Query: 270 VPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQ 329
+G I+ V A D D +N+++TY++ + G+ TI P+ G + + LDRE
Sbjct: 194 ALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGH----FTIHPKKGELQVAKALDREQA 249
Query: 330 AKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLT 389
+ Y L + ATD G PP F Y + E+ P G+ V+ L
Sbjct: 250 SSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLI 309
Query: 390 ATDADEDNR---LHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDS 446
+D D + IT GN F +T G + A+ L + + Y L + A+DS
Sbjct: 310 LSDPDSPENGPPYSFRITKGNNGSAFRVTPD---GWLVTAEGLSRRAQEWYQLQIQASDS 366
Query: 447 G--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQI 504
G S V +++T+ ++YAP +V ED G V + ATD D +
Sbjct: 367 GIPPLSSLTSVHVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDP--QDTL 424
Query: 505 TYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
TYSL+ E E + H F + G I + L R Y VT DG
Sbjct: 425 TYSLAEE---ETLGRH---FSVGAPDGKIIAAQGLPR---GHYSFNVTVSDG 467
Score = 124 bits (300), Expect = 3e-27
Identities = 132/486 (27%), Positives = 212/486 (43%), Gaps = 38/486 (7%)
Query: 497 DVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDG 556
D G NAQ+ YSL + A H F I+ TG I K L + LTV A D
Sbjct: 1 DQGANAQVVYSLP----DSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDL 52
Query: 557 GVP-SLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGR 615
G P LS V +SVV + D PVF ++ + EDA GT V Q+ AT G +
Sbjct: 53 GTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQL-ATLTRPGAE-K 110
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
Y + E+G F +D +G++ N +LD E+ + L + S V +
Sbjct: 111 TGYRV-VSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMV 169
Query: 676 KIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSF 735
I D+N+ P F D + + EN+ +G I + A D D N+ + YS+ GG+ F
Sbjct: 170 NITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHF 229
Query: 736 SLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAP 792
++ ++G EL LD E Y L +RA PPL D + I V DVNDN P
Sbjct: 230 TIHPKKG----ELQVAKALDREQ-ASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPP 284
Query: 793 VMKDFQIIFN-NYKDCFPVG-PFGRVPAYDADVTDK---LQYRILSGNNANLILLNETTG 847
+ FQ+ ++ ++ P+G ++ D D + +RI GNN + + G
Sbjct: 285 --RFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT-PDG 341
Query: 848 SMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQLSVRLITEEMLLNSITVRLNDMTAE 906
+ + L+ + +++ +D G+ + ++ + V +TE+ + L ++
Sbjct: 342 WLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVHVH-VTEQSHYAPSALPL-EIFIT 399
Query: 907 QFLSPLLGFFIDGLAAIIPCPKENIYIFSVQDDTDVTGNILNVSFSARRPDAEVGVA-GD 965
G + + A P++ + +++T L FS PD ++ A G
Sbjct: 400 VGEDEFQGGMVGKIHATDRDPQDTLTYSLAEEET------LGRHFSVGAPDGKIIAAQGL 453
Query: 966 PSPHYS 971
P HYS
Sbjct: 454 PRGHYS 459
Score = 93.9 bits (223), Expect = 7e-18
Identities = 83/332 (25%), Positives = 144/332 (43%), Gaps = 34/332 (10%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+N+ D N+H P F Y V E A G +LT+ ATD+D N+++ Y+ L+ + L
Sbjct: 169 VNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYS--LIGGNQL 226
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
F I + G L +LDRE+ + Y++ ++ATD P L
Sbjct: 227 GH-----------------FTIHPKKGELQVAKALDREQASSYSLKLRATDSGQP---PL 266
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANS-AIRY 189
I + + D NDN P+F + Y+ +V E+ + + ++ +D D N +
Sbjct: 267 HEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSK--VLQLILSDPDSPENGPPYSF 324
Query: 190 AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRD 249
I GN F + + G + + L Y+L I+A D G P S+ T + +++ +
Sbjct: 325 RITKGNNGSAFRV-TPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVHVHVTE 383
Query: 250 VNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPI 309
+ AP +V E+ G + ++ A D D LTY++ +++ G
Sbjct: 384 QSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDP--QDTLTYSLAEEETLGR---HF 438
Query: 310 TIDPRSGWVYTSGQLDRETQAKYQLLVTATDG 341
++ G + + L R Y VT +DG
Sbjct: 439 SVGAPDGKIIAAQGLPR---GHYSFNVTVSDG 467
Score = 36.7 bits (81), Expect = 1.2
Identities = 24/80 (30%), Positives = 33/80 (41%), Gaps = 7/80 (8%)
Query: 1276 VKNKDFVGCISDFYIDHKFIDL---NSYVA---DNGTLAGCPEKRSRCSSAPCYNGAECS 1329
V K F GC+ ++ + +DL VA + L C CS C NG +CS
Sbjct: 678 VSLKGFEGCLDAVVVNEEALDLLAPGKTVAGLLETQALTQCCLHSDYCSQNTCLNGGKCS 737
Query: 1330 DLWDT-YICDCKEGHTGKDC 1348
Y+C C +GK C
Sbjct: 738 WTHGAGYVCKCPPQFSGKHC 757
Score = 35.9 bits (79), Expect = 2.1
Identities = 33/124 (26%), Positives = 52/124 (41%), Gaps = 18/124 (14%)
Query: 1042 FTCQCPEGFTGVNCETILTKASCEVDGDGSICRSGSQCVARREGGILCQGCSIDAAYTTA 1101
+ C+CP F+G +CE + +C + C G C+ +G C+ YT
Sbjct: 744 YVCKCPPQFSGKHCEQ--GRENCTF----APCLEGGTCILSPKGA----SCNCPHPYTGD 793
Query: 1102 VCELRARSFPVSSFLTFPGLKRRH-------RIHLKLKFATQTTSGLLLYNGRYNERHDF 1154
CE+ AR L P ++R I + + F +T GLL Y R + H
Sbjct: 794 RCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYCRRC-KSHKP 852
Query: 1155 LALE 1158
+A+E
Sbjct: 853 VAME 856
>BC112084-1|AAI12085.1| 823|Homo sapiens protocadherin gamma
subfamily A, 1 protein.
Length = 823
Score = 219 bits (535), Expect = 1e-55
Identities = 185/609 (30%), Positives = 277/609 (45%), Gaps = 34/609 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ ++ + V D++ + V IID NDN P
Sbjct: 74 LFALNPRSGSLITARRIDREELCAQSMPCLVSFNIL-VEDKMK-LFPVEVEIIDINDNTP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
QF + ++E T I+ D DVG NS Y + ++ FS+D G
Sbjct: 132 QFQLEELEFKMNE--ITTPGTRISLPFGQDLDVGMNSLQSYQL---SSNPHFSLDVQQGA 186
Query: 208 ------DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
++ L LD E+ + L++ A DGG P RS T ++ I + D NDN P F +
Sbjct: 187 DGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQ 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+ +V ENVP+G ++ V A D DEG N E+TY+ + D+ V +D +G +
Sbjct: 247 YHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDH--RVAQIFRLDSYTGEISNK 304
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E Y + V A DG A + E+ PP
Sbjct: 305 EPLDFEEYKMYSMEVQAQDGAG--LMAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPP 362
Query: 382 GTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ D D DN GN + N L+T + LD + Y +T
Sbjct: 363 GTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKLVDNYYRLVT-ERTLDRELISGYNIT 421
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
++A D G S + + +TD N+ +PVF Y+A + E+ P G ++ V A D D
Sbjct: 422 ITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDS 481
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NAQITYSL + A IN TG + + D E L V ARD G
Sbjct: 482 NENAQITYSLIEDTIQGAPL--SAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGD 539
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYT--ANIME----DALVGTSVSQVGATDADVG 611
P LS + + ++D NDN P + L T + +E A G V++V A D D G
Sbjct: 540 PPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSG 599
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSST 670
N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+T
Sbjct: 600 QNAWLSYRL-LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSAT 657
Query: 671 VIVHIKIED 679
V + + + D
Sbjct: 658 VTLTVAVAD 666
Score = 213 bits (519), Expect = 1e-53
Identities = 161/558 (28%), Positives = 256/558 (45%), Gaps = 28/558 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ I D+NDN P+F + ++E G I D D G+N+ +Y ++ + +
Sbjct: 121 VEIIDINDNTPQFQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLSSNPHF-S 179
Query: 305 VDLPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ D P+ + LDRE +A + L++TA+DGG+P RS T
Sbjct: 180 LDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNP 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F QY + + E+ P GT ++ + ATD DE + + Y + R + G
Sbjct: 240 PAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTG 299
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFED 481
I+ +PLDF++ + Y + V A D G V I + D N+ AP T +V E+
Sbjct: 300 EISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPEN 359
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
P GT + ++S D D G N T + + + D + + T + LDR
Sbjct: 360 FPPGTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKLVDNYY-------RLVTERTLDR 412
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVS 601
E +SGY +T+TA D G P+LS T + + V D+NDN PVF Q Y+A I E+ G S+
Sbjct: 413 ELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIF 472
Query: 602 QVGATDADVGLNGRIHYELDPKDREEGS-----FVIDPASGVIRTNKALDRESVATHDLK 656
V A D D N +I Y L +D +G+ I+ +GV+ ++ D E LK
Sbjct: 473 SVRAHDLDSNENAQITYSL-IEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLK 531
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYIS---ENSPI----GTTIGEI 709
+A D G PP SS V + + + D ND+ P L S E +P+ G + ++
Sbjct: 532 VMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKV 591
Query: 710 RAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR- 768
A D D G NA + Y + + FS+ G + LD ++ ++ + ++
Sbjct: 592 VAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAL---LDRDALKQSLVVAVQD 648
Query: 769 AASPPLWNDVRVEILVTD 786
PPL V + + V D
Sbjct: 649 HGQPPLSATVTLTVAVAD 666
Score = 191 bits (465), Expect = 4e-47
Identities = 160/542 (29%), Positives = 253/542 (46%), Gaps = 35/542 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRG-- 421
F + E ++ E PGT + D D N L Y+++ + FS+ Q G
Sbjct: 133 FQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLS---SNPHFSLDVQQGADGP 189
Query: 422 ---LITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
+ + PLD ++E + L ++A+D G RS T + I + DAN+ P F A Y
Sbjct: 190 QHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHI 249
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+V E+ P+GT +L+V+ATD D G N ++TYS + + VA Q F ++ TG I+
Sbjct: 250 NVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNV--DHRVA---QIFRLDSYTGEISNK 304
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LD E Y + V A+DG L V I V+DVNDN P T + E+
Sbjct: 305 EPLDFEEYKMYSMEVQAQDGA--GLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPP 362
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
GT ++ + D D G NG + + ++D ++ T + LDRE ++ +++
Sbjct: 363 GTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKLVDNYYRLV-TERTLDRELISGYNIT 421
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
AID GTP S+ + + + DIND+ PVF D + YI EN+P G +I +RAHD D
Sbjct: 422 ITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDS 481
Query: 717 GPNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPP 773
NA + YS I+ S SD L + DYE R + +++ R + PP
Sbjct: 482 NENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDPP 541
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------DADV 823
L ++V + + + D NDNAP + + + + + P P Y D+
Sbjct: 542 LSSNVSLSLFLLDQNDNAPEIL-YPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQ 600
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQL 882
L YR+L + L + TG + + L ++ V+V D G + A + L
Sbjct: 601 NAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTL 660
Query: 883 SV 884
+V
Sbjct: 661 TV 662
Score = 186 bits (452), Expect = 1e-45
Identities = 160/585 (27%), Positives = 263/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND++P F++++ E + E + GT + D D+G N+ Y + +
Sbjct: 120 EVEIIDINDNTPQFQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQL------S 173
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
NP VQ DG + ++ ++ LDRE+ A + +++ A+D PV
Sbjct: 174 SNPH--------FSLDVQQ--GADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S T I++ ++D NDN P F++ Y ++V E++ + + + ATD D GAN +
Sbjct: 223 --SGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPL--GTQLLMVNATDPDEGANGEVT 278
Query: 189 YAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ + F +DS +G++S + LD+E+ + Y + ++AQDG ++LI
Sbjct: 279 YSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAK--VKVLIK 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDNAP + +V EN P G I + +D D G N T + GN
Sbjct: 337 VLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCFI-----PGN-- 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ Y T LDRE + Y + +TA D G P S
Sbjct: 390 LPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNS 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRG---RFSITSQN 418
F Y + E+ P G + ++ A D D E+ ++ Y + +G ++ +
Sbjct: 450 PVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ + D++Q R L V A DSG S + + + D N+ AP ++ P
Sbjct: 510 DTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPT 569
Query: 475 TASV-FEDAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP+ G V V A D D G NA ++Y L A F +
Sbjct: 570 DGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK-------ASEPGLFSVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 164 bits (399), Expect = 4e-39
Identities = 134/471 (28%), Positives = 208/471 (44%), Gaps = 42/471 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND+ P F QY +V E GT +L + ATD D G N EV Y+ V
Sbjct: 230 IQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVD---- 285
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V +FR+D +G + + LD E+ Y++ V+A D A L
Sbjct: 286 -------------HRVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAG-----L 327
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ + + ++D NDN P+ + + T +V E+ +IA I D D G N
Sbjct: 328 MAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFP--PGTIIALISVHDQDSGDNGYTT-C 384
Query: 191 IIGGNTQMQFSIDSLSGDV-SLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I GN + F ++ L + LV +TLD E + Y + I A D G+P+ S T + + +
Sbjct: 385 FIPGN--LPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLV 442
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NVD 306
D+NDN+P F+ + + EN P G SI V+A+D D NA++TY++ + G +
Sbjct: 443 TDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLS 502
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
++I+ +G +Y D E QL V A D GDPP S+ +
Sbjct: 503 AYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEI 562
Query: 367 M------PGQYEVELAE-DEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G VELA PG V + A D D L Y + + G FS+
Sbjct: 563 LYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLH 622
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A+ + +
Sbjct: 623 TGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADRISDI 671
Score = 160 bits (388), Expect = 8e-38
Identities = 118/343 (34%), Positives = 161/343 (46%), Gaps = 14/343 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V++ I D N+ P F+ + E GT + + D DVG+N+ +Y LS SN
Sbjct: 119 VEVEIIDINDNTPQFQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLS---SN 175
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ QQ PQ + LDRE + + L +TA DGG P S T + I VVD
Sbjct: 176 PHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDA 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD-REEGSFVID 633
NDN P F Q Y N+ E+ +GT + V ATD D G NG + Y D R F +D
Sbjct: 236 NDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLD 295
Query: 634 PASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+G I + LD E + ++ A DG + V V IK+ D+ND+ P +T
Sbjct: 296 SYTGEISNKEPLDFEEYKMYSMEVQAQDGA--GLMAKVKVLIKVLDVNDNAPEVTITSVT 353
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVD 753
+ EN P GT I I HD D G N I G + F LE + + LVT
Sbjct: 354 TAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPG---NLPFKLE-KLVDNYYRLVTERT 409
Query: 754 LDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPV 793
LD E Y + I A +P L + + +LVTD+NDN+PV
Sbjct: 410 LDREL-ISGYNITITAIDQGTPALSTETHISLLVTDINDNSPV 451
Score = 130 bits (314), Expect = 7e-29
Identities = 90/278 (32%), Positives = 136/278 (48%), Gaps = 16/278 (5%)
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLT-VTARDGGVPSLSDTTDVEISVVDVNDNEPVFK 582
F +NP++G++ T + +DRE + + + + + V VE+ ++D+NDN P F+
Sbjct: 75 FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQ 134
Query: 583 QQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASG 637
+ + E GT +S D DVG+N Y+L D ++G+ P
Sbjct: 135 LEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLSSNPHFSLDVQQGA--DGPQHP 192
Query: 638 VIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYIS 697
+ LDRE A H L A DGG P +S T+ ++I++ D ND+PP F +
Sbjct: 193 EMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVP 252
Query: 698 ENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDLD 755
EN P+GT + + A DPDEG N V YS D + F L++ G E+ LD
Sbjct: 253 ENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTG----EISNKEPLD 308
Query: 756 YESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
+E K Y + ++A L V+V I V DVNDNAP
Sbjct: 309 FEE-YKMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAP 345
Score = 84.2 bits (199), Expect = 6e-15
Identities = 64/247 (25%), Positives = 104/247 (42%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+SPVF Y A + E G ++ +++A D D +NA++ Y++
Sbjct: 437 HISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSL---IE 493
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
DT+ + I+ +G L S D E+ + V A D P
Sbjct: 494 DTIQ-----------GAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDP-- 540
Query: 128 DRLSSTATIHVNIIDDNDN-----YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN YP T +S ++ K+ A D D G
Sbjct: 541 -PLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSG 599
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ + FS+ +G+V + L LV+ QD G P S T
Sbjct: 600 QNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT 659
Query: 243 LLINIRD 249
L + + D
Sbjct: 660 LTVAVAD 666
>BC112082-1|AAI12083.1| 823|Homo sapiens protocadherin gamma
subfamily A, 1, isoform 2 precursor protein.
Length = 823
Score = 219 bits (535), Expect = 1e-55
Identities = 185/609 (30%), Positives = 277/609 (45%), Gaps = 34/609 (5%)
Query: 89 VFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYP 148
+F ++ RSG+L+T +DRE++ ++ + V D++ + V IID NDN P
Sbjct: 74 LFALNPRSGSLITARRIDREELCAQSMPCLVSFNIL-VEDKMK-LFPVEVEIIDINDNTP 131
Query: 149 QFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG- 207
QF + ++E T I+ D DVG NS Y + ++ FS+D G
Sbjct: 132 QFQLEELEFKMNE--ITTPGTRISLPFGQDLDVGMNSLQSYQL---SSNPHFSLDVQQGA 186
Query: 208 ------DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSL 261
++ L LD E+ + L++ A DGG P RS T ++ I + D NDN P F +
Sbjct: 187 DGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQ 246
Query: 262 FQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTS 321
+ +V ENVP+G ++ V A D DEG N E+TY+ + D+ V +D +G +
Sbjct: 247 YHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDH--RVAQIFRLDSYTGEISNK 304
Query: 322 GQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E Y + V A DG A + E+ PP
Sbjct: 305 EPLDFEEYKMYSMEVQAQDGAG--LMAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPP 362
Query: 382 GTPVVTLTATDADE-DNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLT 440
GT + ++ D D DN GN + N L+T + LD + Y +T
Sbjct: 363 GTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKLVDNYYRLVT-ERTLDRELISGYNIT 421
Query: 441 VSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDV 498
++A D G S + + +TD N+ +PVF Y+A + E+ P G ++ V A D D
Sbjct: 422 ITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDS 481
Query: 499 GINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
NAQITYSL + A IN TG + + D E L V ARD G
Sbjct: 482 NENAQITYSLIEDTIQGAPL--SAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGD 539
Query: 559 PSLSDTTDVEISVVDVNDNEP-VFKQQLYT--ANIME----DALVGTSVSQVGATDADVG 611
P LS + + ++D NDN P + L T + +E A G V++V A D D G
Sbjct: 540 PPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSG 599
Query: 612 LNGRIHYELDPKDREEGSFVIDPASGVIRTNKA-LDRESVATHDLKAVAIDGGTPPQSST 670
N + Y L K E G F + +G +RT +A LDR+++ + AV D G PP S+T
Sbjct: 600 QNAWLSYRL-LKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ-DHGQPPLSAT 657
Query: 671 VIVHIKIED 679
V + + + D
Sbjct: 658 VTLTVAVAD 666
Score = 213 bits (519), Expect = 1e-53
Identities = 161/558 (28%), Positives = 256/558 (45%), Gaps = 28/558 (5%)
Query: 245 INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGN 304
+ I D+NDN P+F + ++E G I D D G+N+ +Y ++ + +
Sbjct: 121 VEIIDINDNTPQFQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLSSNPHF-S 179
Query: 305 VDLPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+D+ D P+ + LDRE +A + L++TA+DGG+P RS T
Sbjct: 180 LDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNP 239
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGNTRGRFSITSQNGRG 421
F QY + + E+ P GT ++ + ATD DE + + Y + R + G
Sbjct: 240 PAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTG 299
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFED 481
I+ +PLDF++ + Y + V A D G V I + D N+ AP T +V E+
Sbjct: 300 EISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPEN 359
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
P GT + ++S D D G N T + + + D + + T + LDR
Sbjct: 360 FPPGTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKLVDNYY-------RLVTERTLDR 412
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVS 601
E +SGY +T+TA D G P+LS T + + V D+NDN PVF Q Y+A I E+ G S+
Sbjct: 413 ELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIF 472
Query: 602 QVGATDADVGLNGRIHYELDPKDREEGS-----FVIDPASGVIRTNKALDRESVATHDLK 656
V A D D N +I Y L +D +G+ I+ +GV+ ++ D E LK
Sbjct: 473 SVRAHDLDSNENAQITYSL-IEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLK 531
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYIS---ENSPI----GTTIGEI 709
+A D G PP SS V + + + D ND+ P L S E +P+ G + ++
Sbjct: 532 VMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKV 591
Query: 710 RAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIR- 768
A D D G NA + Y + + FS+ G + LD ++ ++ + ++
Sbjct: 592 VAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAL---LDRDALKQSLVVAVQD 648
Query: 769 AASPPLWNDVRVEILVTD 786
PPL V + + V D
Sbjct: 649 HGQPPLSATVTLTVAVAD 666
Score = 191 bits (465), Expect = 4e-47
Identities = 160/542 (29%), Positives = 253/542 (46%), Gaps = 35/542 (6%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDADED-NRLH-YEITGGNTRGRFSITSQNGRG-- 421
F + E ++ E PGT + D D N L Y+++ + FS+ Q G
Sbjct: 133 FQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLS---SNPHFSLDVQQGADGP 189
Query: 422 ---LITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTA 476
+ + PLD ++E + L ++A+D G RS T + I + DAN+ P F A Y
Sbjct: 190 QHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHI 249
Query: 477 SVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTN 536
+V E+ P+GT +L+V+ATD D G N ++TYS + + VA Q F ++ TG I+
Sbjct: 250 NVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNV--DHRVA---QIFRLDSYTGEISNK 304
Query: 537 KLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV 596
+ LD E Y + V A+DG L V I V+DVNDN P T + E+
Sbjct: 305 EPLDFEEYKMYSMEVQAQDGA--GLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPP 362
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
GT ++ + D D G NG + + ++D ++ T + LDRE ++ +++
Sbjct: 363 GTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKLVDNYYRLV-TERTLDRELISGYNIT 421
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
AID GTP S+ + + + DIND+ PVF D + YI EN+P G +I +RAHD D
Sbjct: 422 ITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDS 481
Query: 717 GPNAVVHYS-IKGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRK-KYELVIR-AASPP 773
NA + YS I+ S SD L + DYE R + +++ R + PP
Sbjct: 482 NENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDPP 541
Query: 774 LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY----------DADV 823
L ++V + + + D NDNAP + + + + + P P Y D+
Sbjct: 542 LSSNVSLSLFLLDQNDNAPEIL-YPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQ 600
Query: 824 TDKLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-GVNEIKAMMQL 882
L YR+L + L + TG + + L ++ V+V D G + A + L
Sbjct: 601 NAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTL 660
Query: 883 SV 884
+V
Sbjct: 661 TV 662
Score = 186 bits (452), Expect = 1e-45
Identities = 160/585 (27%), Positives = 263/585 (44%), Gaps = 59/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ ++D ND++P F++++ E + E + GT + D D+G N+ Y + +
Sbjct: 120 EVEIIDINDNTPQFQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQL------S 173
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
NP VQ DG + ++ ++ LDRE+ A + +++ A+D PV
Sbjct: 174 SNPH--------FSLDVQQ--GADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S T I++ ++D NDN P F++ Y ++V E++ + + + ATD D GAN +
Sbjct: 223 --SGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPL--GTQLLMVNATDPDEGANGEVT 278
Query: 189 YAI--IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y+ + F +DS +G++S + LD+E+ + Y + ++AQDG ++LI
Sbjct: 279 YSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAK--VKVLIK 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDNAP + +V EN P G I + +D D G N T + GN
Sbjct: 337 VLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCFI-----PGN-- 389
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
LP ++ Y T LDRE + Y + +TA D G P S
Sbjct: 390 LPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNS 449
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRG---RFSITSQN 418
F Y + E+ P G + ++ A D D E+ ++ Y + +G ++ +
Sbjct: 450 PVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAP--VFENAPY 474
G++ + D++Q R L V A DSG S + + + D N+ AP ++ P
Sbjct: 510 DTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPT 569
Query: 475 TASV-FEDAPI----GTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQ 529
S E AP+ G V V A D D G NA ++Y L A F +
Sbjct: 570 DGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK-------ASEPGLFSVGLH 622
Query: 530 TGAI-TTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
TG + T LLDR+ + L V +D G P LS T + ++V D
Sbjct: 623 TGEVRTARALLDRDALK-QSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 164 bits (399), Expect = 4e-39
Identities = 134/471 (28%), Positives = 208/471 (44%), Gaps = 42/471 (8%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I V+D ND+ P F QY +V E GT +L + ATD D G N EV Y+ V
Sbjct: 230 IQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVD---- 285
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V +FR+D +G + + LD E+ Y++ V+A D A L
Sbjct: 286 -------------HRVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAG-----L 327
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ + + ++D NDN P+ + + T +V E+ +IA I D D G N
Sbjct: 328 MAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFP--PGTIIALISVHDQDSGDNGYTT-C 384
Query: 191 IIGGNTQMQFSIDSLSGDV-SLV--KTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I GN + F ++ L + LV +TLD E + Y + I A D G+P+ S T + + +
Sbjct: 385 FIPGN--LPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLV 442
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG-NVD 306
D+NDN+P F+ + + EN P G SI V+A+D D NA++TY++ + G +
Sbjct: 443 TDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLS 502
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
++I+ +G +Y D E QL V A D GDPP S+ +
Sbjct: 503 AYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEI 562
Query: 367 M------PGQYEVELAE-DEPPGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQ 417
+ G VELA PG V + A D D L Y + + G FS+
Sbjct: 563 LYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLH 622
Query: 418 NGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPV 468
G + A+ L + + L V+ D G +A V + + A+ + +
Sbjct: 623 TGE--VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADRISDI 671
Score = 160 bits (388), Expect = 8e-38
Identities = 118/343 (34%), Positives = 161/343 (46%), Gaps = 14/343 (4%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
V++ I D N+ P F+ + E GT + + D DVG+N+ +Y LS SN
Sbjct: 119 VEVEIIDINDNTPQFQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLS---SN 175
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ QQ PQ + LDRE + + L +TA DGG P S T + I VVD
Sbjct: 176 PHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDA 235
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKD-REEGSFVID 633
NDN P F Q Y N+ E+ +GT + V ATD D G NG + Y D R F +D
Sbjct: 236 NDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLD 295
Query: 634 PASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLT 693
+G I + LD E + ++ A DG + V V IK+ D+ND+ P +T
Sbjct: 296 SYTGEISNKEPLDFEEYKMYSMEVQAQDGA--GLMAKVKVLIKVLDVNDNAPEVTITSVT 353
Query: 694 FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVD 753
+ EN P GT I I HD D G N I G + F LE + + LVT
Sbjct: 354 TAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPG---NLPFKLE-KLVDNYYRLVTERT 409
Query: 754 LDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPV 793
LD E Y + I A +P L + + +LVTD+NDN+PV
Sbjct: 410 LDREL-ISGYNITITAIDQGTPALSTETHISLLVTDINDNSPV 451
Score = 130 bits (314), Expect = 7e-29
Identities = 90/278 (32%), Positives = 136/278 (48%), Gaps = 16/278 (5%)
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLT-VTARDGGVPSLSDTTDVEISVVDVNDNEPVFK 582
F +NP++G++ T + +DRE + + + + + V VE+ ++D+NDN P F+
Sbjct: 75 FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQ 134
Query: 583 QQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPK-----DREEGSFVIDPASG 637
+ + E GT +S D DVG+N Y+L D ++G+ P
Sbjct: 135 LEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLSSNPHFSLDVQQGA--DGPQHP 192
Query: 638 VIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYIS 697
+ LDRE A H L A DGG P +S T+ ++I++ D ND+PP F +
Sbjct: 193 EMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVP 252
Query: 698 ENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDD--SNSFSLETRQGSDKAELVTMVDLD 755
EN P+GT + + A DPDEG N V YS D + F L++ G E+ LD
Sbjct: 253 ENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTG----EISNKEPLD 308
Query: 756 YESPRKKYELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
+E K Y + ++A L V+V I V DVNDNAP
Sbjct: 309 FEE-YKMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAP 345
Score = 84.2 bits (199), Expect = 6e-15
Identities = 64/247 (25%), Positives = 104/247 (42%), Gaps = 22/247 (8%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H + V D ND+SPVF Y A + E G ++ +++A D D +NA++ Y++
Sbjct: 437 HISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSL---IE 493
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVS 127
DT+ + I+ +G L S D E+ + V A D P
Sbjct: 494 DTIQ-----------GAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDP-- 540
Query: 128 DRLSSTATIHVNIIDDNDN-----YPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVG 182
LSS ++ + ++D NDN YP T +S ++ K+ A D D G
Sbjct: 541 -PLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSG 599
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ + FS+ +G+V + L LV+ QD G P S T
Sbjct: 600 QNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVT 659
Query: 243 LLINIRD 249
L + + D
Sbjct: 660 LTVAVAD 666
>BC028165-1|AAH28165.1| 1159|Homo sapiens protocadherin 17 protein.
Length = 1159
Score = 219 bits (535), Expect = 1e-55
Identities = 167/591 (28%), Positives = 263/591 (44%), Gaps = 34/591 (5%)
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
G + + Y ++ + +D+ SG + + +D E + + + +
Sbjct: 57 GRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEIC 116
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ + I+D+NDNAP F + + +SEN G A+D D G N TY +T D+
Sbjct: 117 MIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDH 176
Query: 302 -TGNVDLPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ D + + LDRE Q + L++TA DGG+PPRSAT
Sbjct: 177 GLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDS 236
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSI 414
F Y VEL E+ P GT V+ L ATDADE + + Y + R FSI
Sbjct: 237 NDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSI 296
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTA--MVQINITDANNYAPVFENA 472
+ G LI V LD+++ + V A D G A V + + D N+ AP
Sbjct: 297 DPKTG--LIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFV 354
Query: 473 PYT-ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE----------AVAHHD 521
++ E AP GT + +V TD D G N Q+ + +V
Sbjct: 355 SVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKL 414
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVF 581
++ N T + T++ LDRET Y +T+ ARDGG P L+ T I ++D NDN P F
Sbjct: 415 EENYDNFYT--VVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRF 472
Query: 582 KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV----IDPASG 637
+ LY + E+ + G + V A D D+G NG + Y + P + S ++P +G
Sbjct: 473 TKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNG 532
Query: 638 VIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKIEDINDSPPV-----FESDC 691
I ++ + E + K +A D G P S V + + D+ND+ PV ++D
Sbjct: 533 AIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDT 592
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
+ N+ +G + +RA D D G + + Y I G+D + F ++ G
Sbjct: 593 AELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSG 643
Score = 210 bits (513), Expect = 5e-53
Identities = 187/629 (29%), Positives = 285/629 (45%), Gaps = 51/629 (8%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D SG L T+ +DRE + R+ + + + +D+ I V I D NDN P FS
Sbjct: 77 VDADSGLLYTKQRIDRESLCRHNAKCQLSLEVF-ANDK--EICMIKVEIQDINDNAPSFS 133
Query: 152 EKTYTVSVDEDISV-TDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS-GD- 208
+ + E+ + T P+ + A D D G N Y + + + F +D S GD
Sbjct: 134 SDQIEMDISENAAPGTRFPLTS---AHDPDAGENGLRTYLLTRDDHGL-FGLDVKSRGDG 189
Query: 209 -----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
+ + K LD EQ + LV+ A DGG P RS T Q+ + + D NDN+P F +
Sbjct: 190 TKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYL 249
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
+ EN P+G ++ + A DADEG N E+ Y+ + V +IDP++G + G
Sbjct: 250 VELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSY-VPDRVRELFSIDPKTGLIRVKGN 308
Query: 324 LDRETQAKYQLLVTATD-GGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E ++ V A D G +P P T F+ + + L+E PP
Sbjct: 309 LDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVR-QGALSEAAPP 367
Query: 382 GTPVVTLTATDAD--EDNRLHYEITGGNTRGR------------FSITSQNGRGLITVA- 426
GT + + TD D ++ +L + GG G F + +N TV
Sbjct: 368 GTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKL-EENYDNFYTVVT 426
Query: 427 -QPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+PLD + + Y +T+ A D G + T I I D N+ P F Y V E+
Sbjct: 427 DRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNI 486
Query: 484 IGTTVLVVSATDSDVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
G + V A D D+G N ++YS L S I + ++ + +NP GAI + + E
Sbjct: 487 PGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVS---VNPTNGAIYALRSFNFE 543
Query: 543 TMSGYLLTVTARDGGVPS-LSDTTDVEISVVDVNDNEPVF---KQQLYTANIM--EDALV 596
+ V A+D G P+ L V ++V+DVNDN PV Q TA + +A +
Sbjct: 544 QTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGL 603
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
G VS V A D+D G +GR+ YE+ ++ F IDP+SG IRT + +L
Sbjct: 604 GYLVSTVRALDSDFGESGRLTYEI-VDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELV 662
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPP 685
D G P S+ + + I ++ S P
Sbjct: 663 VKVTDHGKPTLSA--VAKLIIRSVSGSLP 689
Score = 194 bits (474), Expect = 3e-48
Identities = 167/616 (27%), Positives = 280/616 (45%), Gaps = 41/616 (6%)
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
+ +D SG +YT ++DRE+ ++ + F
Sbjct: 75 LDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFSS 134
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSI-TSQNGRGL---- 422
Q E++++E+ PGT +A D D +N L + + G F + G G
Sbjct: 135 DQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPE 194
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + LD +Q+ + L ++A D G +A VQIN+ D+N+ +PVFE Y + E
Sbjct: 195 LVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPE 254
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP+GT V+ ++ATD+D G N ++ YS SS + + + F I+P+TG I LD
Sbjct: 255 NAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRV----RELFSIDPKTGLIRVKGNLD 310
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALVGTS 599
E + V ARD G + V + ++D NDN P + + + E A GT
Sbjct: 311 YEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTV 370
Query: 600 VSQVGATDADVGLNGRIHYE-LDPKDREEGSFVIDPASGV-------------IRTNKAL 645
++ V TD D G NG++ L G + P V + T++ L
Sbjct: 371 IALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPL 430
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
DRE+ +++ VA DGG+PP +ST IKI D ND+PP F + EN+ G
Sbjct: 431 DRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEY 490
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRK-KY 763
+G + A DPD G N V YSI + S + + ++E + ++
Sbjct: 491 LGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEF 550
Query: 764 ELVIRAASPP--LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG------R 815
+++ + + P L ++ V + V DVNDNAPV+ + N+ + G
Sbjct: 551 KVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIV-LPTLQNDTAELQVPRNAGLGYLVST 609
Query: 816 VPAYDADVTD--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-G 872
V A D+D + +L Y I+ GN+ +L ++ ++G + +V + + V VTD G
Sbjct: 610 VRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHG 669
Query: 873 VNEIKAMMQLSVRLIT 888
+ A+ +L +R ++
Sbjct: 670 KPTLSAVAKLIIRSVS 685
Score = 180 bits (438), Expect = 7e-44
Identities = 161/582 (27%), Positives = 256/582 (43%), Gaps = 55/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ + D ND++P F Q E + E A+ GT A D D G+N Y L+T D
Sbjct: 119 KVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTY---LLTRD- 174
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ R DG + L+ + +LDRE+ +T+++ A D P
Sbjct: 175 ----------DHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPR- 223
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S+T I+V +ID NDN P F +Y V + E+ + V+ + ATDAD G N +
Sbjct: 224 --SATVQINVKVIDSNDNSPVFEAPSYLVELPENAPL--GTVVIDLNATDADEGPNGEVL 279
Query: 189 YAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y+ + + FSID +G + + LDYE+ + ++A+D G ++ +
Sbjct: 280 YSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTV 339
Query: 246 NIRDVNDNAPRF-YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG- 303
+ D NDNAP + S+ Q ++SE P G I V+ D D G N +L + TG
Sbjct: 340 KLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGG 399
Query: 304 -------NVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXX 353
+P ++ Y T LDRETQ +Y + + A DGG PP ++T +
Sbjct: 400 GGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFA 459
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTR-- 409
F G Y +++ E+ PG + ++ A D D ++ + Y I +
Sbjct: 460 IKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDV 519
Query: 410 GRFSITSQN-GRGLITVAQPLDFKQERRYVLTVSATDSGGRS---DTAMVQINITDANNY 465
++ S N G I + +F+Q + + V A DSG + A V++ + D N+
Sbjct: 520 SIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDN 579
Query: 466 APV-----FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH 520
APV +N V +A +G V V A DSD G + ++TY + +
Sbjct: 580 APVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVD-------GND 632
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
D F I+P +G I T + L V D G P+LS
Sbjct: 633 DHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLS 674
Score = 150 bits (364), Expect = 6e-35
Identities = 145/548 (26%), Positives = 231/548 (42%), Gaps = 52/548 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ V+D ND+SPVFE Y + E A GT V+ L ATD D G N EV Y+ D
Sbjct: 231 VKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDR- 289
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V+++F ID ++G + + +LD E+ + V+A D + +
Sbjct: 290 ---------------VRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGP---NPI 331
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ + V +ID NDN P + + + VIA ++ TD D G N ++
Sbjct: 332 PAHCKVTVKLIDRNDNAPSIGFVSVRQGALSE-AAPPGTVIALVRVTDRDSGKNGQLQCR 390
Query: 191 IIGGNT------------QMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSP 235
++GG + F ++ + V T LD E Y + I A+DGGSP
Sbjct: 391 VLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSP 450
Query: 236 SRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT 295
++T I I D NDN PRF L+ V EN G + V A D D G N ++Y+
Sbjct: 451 PLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYS 510
Query: 296 MTDKDYTGNVDL--PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR-SATATX 352
+ + G+V + ++++P +G +Y + E ++ V A D G P + AT
Sbjct: 511 IL-PSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATV 569
Query: 353 XXXXXXXXXXXXXFMPGQYEVELAEDEPP-----GTPVVTLTATDAD--EDNRLHYEITG 405
+ + + AE + P G V T+ A D+D E RL YEI
Sbjct: 570 RVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVD 629
Query: 406 GNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNY 465
GN F I +G I P L V TD G + +A+ ++ I +
Sbjct: 630 GNDDHLFEIDPSSGE--IRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGS 687
Query: 466 APVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFV 525
P E P + ++V +T S + + A IT ++ + N+ + ++ +
Sbjct: 688 LP--EGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIA 745
Query: 526 --INPQTG 531
+PQ G
Sbjct: 746 EYSHPQLG 753
>AL445288-1|CAI17092.1| 1159|Homo sapiens protocadherin 17 protein.
Length = 1159
Score = 219 bits (535), Expect = 1e-55
Identities = 167/591 (28%), Positives = 263/591 (44%), Gaps = 34/591 (5%)
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
G + + Y ++ + +D+ SG + + +D E + + + +
Sbjct: 57 GRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEIC 116
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ + I+D+NDNAP F + + +SEN G A+D D G N TY +T D+
Sbjct: 117 MIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDH 176
Query: 302 -TGNVDLPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ D + + LDRE Q + L++TA DGG+PPRSAT
Sbjct: 177 GLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDS 236
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSI 414
F Y VEL E+ P GT V+ L ATDADE + + Y + R FSI
Sbjct: 237 NDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSI 296
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTA--MVQINITDANNYAPVFENA 472
+ G LI V LD+++ + V A D G A V + + D N+ AP
Sbjct: 297 DPKTG--LIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFV 354
Query: 473 PYT-ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE----------AVAHHD 521
++ E AP GT + +V TD D G N Q+ + +V
Sbjct: 355 SVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKL 414
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVF 581
++ N T + T++ LDRET Y +T+ ARDGG P L+ T I ++D NDN P F
Sbjct: 415 EENYDNFYT--VVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRF 472
Query: 582 KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV----IDPASG 637
+ LY + E+ + G + V A D D+G NG + Y + P + S ++P +G
Sbjct: 473 TKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNG 532
Query: 638 VIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKIEDINDSPPV-----FESDC 691
I ++ + E + K +A D G P S V + + D+ND+ PV ++D
Sbjct: 533 AIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDT 592
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
+ N+ +G + +RA D D G + + Y I G+D + F ++ G
Sbjct: 593 AELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSG 643
Score = 210 bits (513), Expect = 5e-53
Identities = 187/629 (29%), Positives = 285/629 (45%), Gaps = 51/629 (8%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D SG L T+ +DRE + R+ + + + +D+ I V I D NDN P FS
Sbjct: 77 VDADSGLLYTKQRIDRESLCRHNAKCQLSLEVF-ANDK--EICMIKVEIQDINDNAPSFS 133
Query: 152 EKTYTVSVDEDISV-TDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS-GD- 208
+ + E+ + T P+ + A D D G N Y + + + F +D S GD
Sbjct: 134 SDQIEMDISENAAPGTRFPLTS---AHDPDAGENGLRTYLLTRDDHGL-FGLDVKSRGDG 189
Query: 209 -----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
+ + K LD EQ + LV+ A DGG P RS T Q+ + + D NDN+P F +
Sbjct: 190 TKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYL 249
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
+ EN P+G ++ + A DADEG N E+ Y+ + V +IDP++G + G
Sbjct: 250 VELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSY-VPDRVRELFSIDPKTGLIRVKGN 308
Query: 324 LDRETQAKYQLLVTATD-GGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E ++ V A D G +P P T F+ + + L+E PP
Sbjct: 309 LDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVR-QGALSEAAPP 367
Query: 382 GTPVVTLTATDAD--EDNRLHYEITGGNTRGR------------FSITSQNGRGLITVA- 426
GT + + TD D ++ +L + GG G F + +N TV
Sbjct: 368 GTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKL-EENYDNFYTVVT 426
Query: 427 -QPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+PLD + + Y +T+ A D G + T I I D N+ P F Y V E+
Sbjct: 427 DRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNI 486
Query: 484 IGTTVLVVSATDSDVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
G + V A D D+G N ++YS L S I + ++ + +NP GAI + + E
Sbjct: 487 PGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVS---VNPTNGAIYALRSFNFE 543
Query: 543 TMSGYLLTVTARDGGVPS-LSDTTDVEISVVDVNDNEPVF---KQQLYTANIM--EDALV 596
+ V A+D G P+ L V ++V+DVNDN PV Q TA + +A +
Sbjct: 544 QTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGL 603
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
G VS V A D+D G +GR+ YE+ ++ F IDP+SG IRT + +L
Sbjct: 604 GYLVSTVRALDSDFGESGRLTYEI-VDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELV 662
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPP 685
D G P S+ + + I ++ S P
Sbjct: 663 VKVTDHGKPTLSA--VAKLIIRSVSGSLP 689
Score = 194 bits (474), Expect = 3e-48
Identities = 167/616 (27%), Positives = 280/616 (45%), Gaps = 41/616 (6%)
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
+ +D SG +YT ++DRE+ ++ + F
Sbjct: 75 LDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFSS 134
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSI-TSQNGRGL---- 422
Q E++++E+ PGT +A D D +N L + + G F + G G
Sbjct: 135 DQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPE 194
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + LD +Q+ + L ++A D G +A VQIN+ D+N+ +PVFE Y + E
Sbjct: 195 LVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPE 254
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP+GT V+ ++ATD+D G N ++ YS SS + + + F I+P+TG I LD
Sbjct: 255 NAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRV----RELFSIDPKTGLIRVKGNLD 310
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALVGTS 599
E + V ARD G + V + ++D NDN P + + + E A GT
Sbjct: 311 YEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTV 370
Query: 600 VSQVGATDADVGLNGRIHYE-LDPKDREEGSFVIDPASGV-------------IRTNKAL 645
++ V TD D G NG++ L G + P V + T++ L
Sbjct: 371 IALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPL 430
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
DRE+ +++ VA DGG+PP +ST IKI D ND+PP F + EN+ G
Sbjct: 431 DRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEY 490
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRK-KY 763
+G + A DPD G N V YSI + S + + ++E + ++
Sbjct: 491 LGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEF 550
Query: 764 ELVIRAASPP--LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG------R 815
+++ + + P L ++ V + V DVNDNAPV+ + N+ + G
Sbjct: 551 KVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIV-LPTLQNDTAELQVPRNAGLGYLVST 609
Query: 816 VPAYDADVTD--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-G 872
V A D+D + +L Y I+ GN+ +L ++ ++G + +V + + V VTD G
Sbjct: 610 VRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHG 669
Query: 873 VNEIKAMMQLSVRLIT 888
+ A+ +L +R ++
Sbjct: 670 KPTLSAVAKLIIRSVS 685
Score = 180 bits (438), Expect = 7e-44
Identities = 161/582 (27%), Positives = 256/582 (43%), Gaps = 55/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ + D ND++P F Q E + E A+ GT A D D G+N Y L+T D
Sbjct: 119 KVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTY---LLTRD- 174
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ R DG + L+ + +LDRE+ +T+++ A D P
Sbjct: 175 ----------DHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPR- 223
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S+T I+V +ID NDN P F +Y V + E+ + V+ + ATDAD G N +
Sbjct: 224 --SATVQINVKVIDSNDNSPVFEAPSYLVELPENAPL--GTVVIDLNATDADEGPNGEVL 279
Query: 189 YAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y+ + + FSID +G + + LDYE+ + ++A+D G ++ +
Sbjct: 280 YSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTV 339
Query: 246 NIRDVNDNAPRF-YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG- 303
+ D NDNAP + S+ Q ++SE P G I V+ D D G N +L + TG
Sbjct: 340 KLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGG 399
Query: 304 -------NVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXX 353
+P ++ Y T LDRETQ +Y + + A DGG PP ++T +
Sbjct: 400 GGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFA 459
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTR-- 409
F G Y +++ E+ PG + ++ A D D ++ + Y I +
Sbjct: 460 IKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDV 519
Query: 410 GRFSITSQN-GRGLITVAQPLDFKQERRYVLTVSATDSGGRS---DTAMVQINITDANNY 465
++ S N G I + +F+Q + + V A DSG + A V++ + D N+
Sbjct: 520 SIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDN 579
Query: 466 APV-----FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH 520
APV +N V +A +G V V A DSD G + ++TY + +
Sbjct: 580 APVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVD-------GND 632
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
D F I+P +G I T + L V D G P+LS
Sbjct: 633 DHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLS 674
Score = 150 bits (364), Expect = 6e-35
Identities = 145/548 (26%), Positives = 231/548 (42%), Gaps = 52/548 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ V+D ND+SPVFE Y + E A GT V+ L ATD D G N EV Y+ D
Sbjct: 231 VKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDR- 289
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V+++F ID ++G + + +LD E+ + V+A D + +
Sbjct: 290 ---------------VRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGP---NPI 331
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ + V +ID NDN P + + + VIA ++ TD D G N ++
Sbjct: 332 PAHCKVTVKLIDRNDNAPSIGFVSVRQGALSE-AAPPGTVIALVRVTDRDSGKNGQLQCR 390
Query: 191 IIGGNT------------QMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSP 235
++GG + F ++ + V T LD E Y + I A+DGGSP
Sbjct: 391 VLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSP 450
Query: 236 SRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT 295
++T I I D NDN PRF L+ V EN G + V A D D G N ++Y+
Sbjct: 451 PLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYS 510
Query: 296 MTDKDYTGNVDL--PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR-SATATX 352
+ + G+V + ++++P +G +Y + E ++ V A D G P + AT
Sbjct: 511 IL-PSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATV 569
Query: 353 XXXXXXXXXXXXXFMPGQYEVELAEDEPP-----GTPVVTLTATDAD--EDNRLHYEITG 405
+ + + AE + P G V T+ A D+D E RL YEI
Sbjct: 570 RVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVD 629
Query: 406 GNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNY 465
GN F I +G I P L V TD G + +A+ ++ I +
Sbjct: 630 GNDDHLFEIDPSSGE--IRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGS 687
Query: 466 APVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFV 525
P E P + ++V +T S + + A IT ++ + N+ + ++ +
Sbjct: 688 LP--EGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIA 745
Query: 526 --INPQTG 531
+PQ G
Sbjct: 746 EYSHPQLG 753
>AL445216-1|CAH71250.1| 1159|Homo sapiens protocadherin 17 protein.
Length = 1159
Score = 219 bits (535), Expect = 1e-55
Identities = 167/591 (28%), Positives = 263/591 (44%), Gaps = 34/591 (5%)
Query: 182 GANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTT 241
G + + Y ++ + +D+ SG + + +D E + + + +
Sbjct: 57 GRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEIC 116
Query: 242 QLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDY 301
+ + I+D+NDNAP F + + +SEN G A+D D G N TY +T D+
Sbjct: 117 MIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDH 176
Query: 302 -TGNVDLPITID-PRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXX 359
+D+ D + + LDRE Q + L++TA DGG+PPRSAT
Sbjct: 177 GLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDS 236
Query: 360 XXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITG---GNTRGRFSI 414
F Y VEL E+ P GT V+ L ATDADE + + Y + R FSI
Sbjct: 237 NDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSI 296
Query: 415 TSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTA--MVQINITDANNYAPVFENA 472
+ G LI V LD+++ + V A D G A V + + D N+ AP
Sbjct: 297 DPKTG--LIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFV 354
Query: 473 PYT-ASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE----------AVAHHD 521
++ E AP GT + +V TD D G N Q+ + +V
Sbjct: 355 SVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKL 414
Query: 522 QQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVF 581
++ N T + T++ LDRET Y +T+ ARDGG P L+ T I ++D NDN P F
Sbjct: 415 EENYDNFYT--VVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRF 472
Query: 582 KQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREEGSFV----IDPASG 637
+ LY + E+ + G + V A D D+G NG + Y + P + S ++P +G
Sbjct: 473 TKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNG 532
Query: 638 VIRTNKALDRESVATHDLKAVAIDGGTPPQ-SSTVIVHIKIEDINDSPPV-----FESDC 691
I ++ + E + K +A D G P S V + + D+ND+ PV ++D
Sbjct: 533 AIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDT 592
Query: 692 LTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQG 742
+ N+ +G + +RA D D G + + Y I G+D + F ++ G
Sbjct: 593 AELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSG 643
Score = 210 bits (513), Expect = 5e-53
Identities = 187/629 (29%), Positives = 285/629 (45%), Gaps = 51/629 (8%)
Query: 92 IDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFS 151
+D SG L T+ +DRE + R+ + + + +D+ I V I D NDN P FS
Sbjct: 77 VDADSGLLYTKQRIDRESLCRHNAKCQLSLEVF-ANDK--EICMIKVEIQDINDNAPSFS 133
Query: 152 EKTYTVSVDEDISV-TDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLS-GD- 208
+ + E+ + T P+ + A D D G N Y + + + F +D S GD
Sbjct: 134 SDQIEMDISENAAPGTRFPLTS---AHDPDAGENGLRTYLLTRDDHGL-FGLDVKSRGDG 189
Query: 209 -----VSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQ 263
+ + K LD EQ + LV+ A DGG P RS T Q+ + + D NDN+P F +
Sbjct: 190 TKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYL 249
Query: 264 ESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQ 323
+ EN P+G ++ + A DADEG N E+ Y+ + V +IDP++G + G
Sbjct: 250 VELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSY-VPDRVRELFSIDPKTGLIRVKGN 308
Query: 324 LDRETQAKYQLLVTATD-GGDP-PRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPP 381
LD E ++ V A D G +P P T F+ + + L+E PP
Sbjct: 309 LDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVR-QGALSEAAPP 367
Query: 382 GTPVVTLTATDAD--EDNRLHYEITGGNTRGR------------FSITSQNGRGLITVA- 426
GT + + TD D ++ +L + GG G F + +N TV
Sbjct: 368 GTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKL-EENYDNFYTVVT 426
Query: 427 -QPLDFKQERRYVLTVSATDSGGR--SDTAMVQINITDANNYAPVFENAPYTASVFEDAP 483
+PLD + + Y +T+ A D G + T I I D N+ P F Y V E+
Sbjct: 427 DRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNI 486
Query: 484 IGTTVLVVSATDSDVGINAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRE 542
G + V A D D+G N ++YS L S I + ++ + +NP GAI + + E
Sbjct: 487 PGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVS---VNPTNGAIYALRSFNFE 543
Query: 543 TMSGYLLTVTARDGGVPS-LSDTTDVEISVVDVNDNEPVF---KQQLYTANIM--EDALV 596
+ V A+D G P+ L V ++V+DVNDN PV Q TA + +A +
Sbjct: 544 QTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGL 603
Query: 597 GTSVSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLK 656
G VS V A D+D G +GR+ YE+ ++ F IDP+SG IRT + +L
Sbjct: 604 GYLVSTVRALDSDFGESGRLTYEI-VDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELV 662
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPP 685
D G P S+ + + I ++ S P
Sbjct: 663 VKVTDHGKPTLSA--VAKLIIRSVSGSLP 689
Score = 194 bits (474), Expect = 3e-48
Identities = 167/616 (27%), Positives = 280/616 (45%), Gaps = 41/616 (6%)
Query: 309 ITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMP 368
+ +D SG +YT ++DRE+ ++ + F
Sbjct: 75 LDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFSS 134
Query: 369 GQYEVELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSI-TSQNGRGL---- 422
Q E++++E+ PGT +A D D +N L + + G F + G G
Sbjct: 135 DQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPE 194
Query: 423 ITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINIT--DANNYAPVFENAPYTASVFE 480
+ + + LD +Q+ + L ++A D G +A VQIN+ D+N+ +PVFE Y + E
Sbjct: 195 LVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPE 254
Query: 481 DAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLD 540
+AP+GT V+ ++ATD+D G N ++ YS SS + + + F I+P+TG I LD
Sbjct: 255 NAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRV----RELFSIDPKTGLIRVKGNLD 310
Query: 541 RETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEP-VFKQQLYTANIMEDALVGTS 599
E + V ARD G + V + ++D NDN P + + + E A GT
Sbjct: 311 YEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTV 370
Query: 600 VSQVGATDADVGLNGRIHYE-LDPKDREEGSFVIDPASGV-------------IRTNKAL 645
++ V TD D G NG++ L G + P V + T++ L
Sbjct: 371 IALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPL 430
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
DRE+ +++ VA DGG+PP +ST IKI D ND+PP F + EN+ G
Sbjct: 431 DRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEY 490
Query: 706 IGEIRAHDPDEGPNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRK-KY 763
+G + A DPD G N V YSI + S + + ++E + ++
Sbjct: 491 LGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEF 550
Query: 764 ELVIRAASPP--LWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFG------R 815
+++ + + P L ++ V + V DVNDNAPV+ + N+ + G
Sbjct: 551 KVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIV-LPTLQNDTAELQVPRNAGLGYLVST 609
Query: 816 VPAYDADVTD--KLQYRILSGNNANLILLNETTGSMTLSPQLNTNVPKLATMEVSVTD-G 872
V A D+D + +L Y I+ GN+ +L ++ ++G + +V + + V VTD G
Sbjct: 610 VRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHG 669
Query: 873 VNEIKAMMQLSVRLIT 888
+ A+ +L +R ++
Sbjct: 670 KPTLSAVAKLIIRSVS 685
Score = 180 bits (438), Expect = 7e-44
Identities = 161/582 (27%), Positives = 256/582 (43%), Gaps = 55/582 (9%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ + D ND++P F Q E + E A+ GT A D D G+N Y L+T D
Sbjct: 119 KVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTY---LLTRD- 174
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDG-RSGALLTRASLDREKVARYTVLVKATDQASPVSD 128
+ R DG + L+ + +LDRE+ +T+++ A D P
Sbjct: 175 ----------DHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPR- 223
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S+T I+V +ID NDN P F +Y V + E+ + V+ + ATDAD G N +
Sbjct: 224 --SATVQINVKVIDSNDNSPVFEAPSYLVELPENAPL--GTVVIDLNATDADEGPNGEVL 279
Query: 189 YAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLI 245
Y+ + + FSID +G + + LDYE+ + ++A+D G ++ +
Sbjct: 280 YSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTV 339
Query: 246 NIRDVNDNAPRF-YTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTG- 303
+ D NDNAP + S+ Q ++SE P G I V+ D D G N +L + TG
Sbjct: 340 KLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGG 399
Query: 304 -------NVDLPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXX 353
+P ++ Y T LDRETQ +Y + + A DGG PP ++T +
Sbjct: 400 GGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFA 459
Query: 354 XXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTR-- 409
F G Y +++ E+ PG + ++ A D D ++ + Y I +
Sbjct: 460 IKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDV 519
Query: 410 GRFSITSQN-GRGLITVAQPLDFKQERRYVLTVSATDSGGRS---DTAMVQINITDANNY 465
++ S N G I + +F+Q + + V A DSG + A V++ + D N+
Sbjct: 520 SIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDN 579
Query: 466 APV-----FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHH 520
APV +N V +A +G V V A DSD G + ++TY + +
Sbjct: 580 APVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVD-------GND 632
Query: 521 DQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLS 562
D F I+P +G I T + L V D G P+LS
Sbjct: 633 DHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLS 674
Score = 150 bits (364), Expect = 6e-35
Identities = 145/548 (26%), Positives = 231/548 (42%), Gaps = 52/548 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
+ V+D ND+SPVFE Y + E A GT V+ L ATD D G N EV Y+ D
Sbjct: 231 VKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDR- 289
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
V+++F ID ++G + + +LD E+ + V+A D + +
Sbjct: 290 ---------------VRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGP---NPI 331
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
+ + V +ID NDN P + + + VIA ++ TD D G N ++
Sbjct: 332 PAHCKVTVKLIDRNDNAPSIGFVSVRQGALSE-AAPPGTVIALVRVTDRDSGKNGQLQCR 390
Query: 191 IIGGNT------------QMQFSIDSLSGDVSLVKT---LDYEQVRSYRLVIRAQDGGSP 235
++GG + F ++ + V T LD E Y + I A+DGGSP
Sbjct: 391 VLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSP 450
Query: 236 SRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT 295
++T I I D NDN PRF L+ V EN G + V A D D G N ++Y+
Sbjct: 451 PLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYS 510
Query: 296 MTDKDYTGNVDL--PITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPR-SATATX 352
+ + G+V + ++++P +G +Y + E ++ V A D G P + AT
Sbjct: 511 IL-PSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATV 569
Query: 353 XXXXXXXXXXXXXFMPGQYEVELAEDEPP-----GTPVVTLTATDAD--EDNRLHYEITG 405
+ + + AE + P G V T+ A D+D E RL YEI
Sbjct: 570 RVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVD 629
Query: 406 GNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNY 465
GN F I +G I P L V TD G + +A+ ++ I +
Sbjct: 630 GNDDHLFEIDPSSGE--IRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGS 687
Query: 466 APVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFV 525
P E P + ++V +T S + + A IT ++ + N+ + ++ +
Sbjct: 688 LP--EGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIA 745
Query: 526 --INPQTG 531
+PQ G
Sbjct: 746 EYSHPQLG 753
>BC093815-1|AAH93815.1| 1135|Homo sapiens protocadherin 18 protein.
Length = 1135
Score = 219 bits (534), Expect = 2e-55
Identities = 183/631 (29%), Positives = 297/631 (47%), Gaps = 50/631 (7%)
Query: 170 VIAKIKATDADVGAN----SAIRY-AIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYR 224
VIA++ ADV S +R+ A+ GN+ + ++ +G++S+ T+D EQ+
Sbjct: 43 VIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPL-LVVNEDNGEISIGATIDREQLCQKN 101
Query: 225 LVIRAQDGGSPSRSNTTQLL---INIRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQA 281
L + + QL + + D+NDN+P+F SL +SE+ +G I A
Sbjct: 102 LNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSA 161
Query: 282 YDADEGVNAELTYTMTDKDYTGNVDLPITID-PRSGWVYTSGQLDRETQAKYQLLVTATD 340
+D D G N+ TY+++ D+ N+++ D + + +LDRE ++ Y+L +TA+D
Sbjct: 162 FDPDVGENSLHTYSLSANDFF-NIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASD 220
Query: 341 GGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNR 398
G P RS ++ F Y ++L E+ P GT ++ L ATD DE + +
Sbjct: 221 MGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGK 280
Query: 399 LHYEIT---GGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGRSDTA-- 453
+ Y + F I S+ RG +T+ + +D++ + Y + V A D G S A
Sbjct: 281 IVYSFSSHVSPKIMETFKIDSE--RGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHC 338
Query: 454 MVQINITDANNYAP------VFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYS 507
+ I + D N+ P + + +FE PI T V +V D D G+N +I
Sbjct: 339 KIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCK 398
Query: 508 LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDV 567
L + ++ ++ I TN LDRE S Y LTV A D G PSLS
Sbjct: 399 LHGHGHFKLQKTYENNYL-------ILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHF 451
Query: 568 EISVVDVNDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDREE 627
+ + D+NDN P F++ Y I E+ G ++ V ATD D+G NG++ Y +
Sbjct: 452 TVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILG 511
Query: 628 GSF----VIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQ--SSTVIVHIKIEDIN 681
S IDP++G I + D E V+ A DGG+P Q S+T +V + I D N
Sbjct: 512 SSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVV-LTIIDEN 570
Query: 682 DSPPV-----FESDCLTFYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFS 736
D+ PV ++ I + + G + IRA D D G NA + +I G++ N F
Sbjct: 571 DNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFI 630
Query: 737 LETRQGSDKAELVTMVDLDYESPRKKYELVI 767
++ R ++ T V +D P ++EL +
Sbjct: 631 IDPR----SCDIHTNVSMD-SVPYTEWELSV 656
Score = 207 bits (506), Expect = 4e-52
Identities = 174/611 (28%), Positives = 273/611 (44%), Gaps = 34/611 (5%)
Query: 96 SGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQFSEKTY 155
+G + A++DRE++ + + + I V ++D NDN PQFS
Sbjct: 83 NGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLI 142
Query: 156 TVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGG---NTQMQFSIDSLS-GDVSL 211
+ + E +V I A D DVG NS Y++ N +++ D ++ +
Sbjct: 143 PIEISESAAVGTR--IPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIV 200
Query: 212 VKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQESVSENVP 271
V+ LD E SY L + A D G P RS ++ L I+I D NDN+P F + + EN P
Sbjct: 201 VRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSP 260
Query: 272 IGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAK 331
+G ++ + A D DEG N ++ Y+ + + + ID G + Q+D E
Sbjct: 261 VGTLLLDLNATDPDEGANGKIVYSFSSH-VSPKIMETFKIDSERGHLTLFKQVDYEITKS 319
Query: 332 YQLLVTATDGGDPPRSATA-------TXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTP 384
Y++ V A D G P S A PG+ E+ + P
Sbjct: 320 YEIDVQAQDLG--PNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDT 377
Query: 385 VVTLTATDADEDNRLHYEITGG-NTRGRFSI--TSQNGRGLITVAQPLDFKQERRYVLTV 441
V L D+D+ L+ EI + G F + T +N ++T A LD ++ Y LTV
Sbjct: 378 FVALVRVQ-DKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNAT-LDREKRSEYSLTV 435
Query: 442 SATDSGGRSDTAMVQ--INITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVG 499
A D G S + + + I D N+ P F+ + Y + E+ G + V+ATD D+G
Sbjct: 436 IAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLG 495
Query: 500 INAQITYS-LSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGV 558
N Q+TY+ L S I ++ + I+P GAI ++ D E +S V ARDGG
Sbjct: 496 ENGQVTYTILESFILGSSITTY---VTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGS 552
Query: 559 PS-LSDTTDVEISVVDVNDNEPV-----FKQQLYTANIMEDALVGTSVSQVGATDADVGL 612
P L T V ++++D NDN PV + I + A G V+++ A D D G+
Sbjct: 553 PKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGV 612
Query: 613 NGRIHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVI 672
N + + EE F+IDP S I TN ++D +L + D G P + V+
Sbjct: 613 NAELSCAI-VAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVL 671
Query: 673 VHIKIEDINDS 683
+ I + +S
Sbjct: 672 LKCMIFEYAES 682
Score = 189 bits (460), Expect = 1e-46
Identities = 163/578 (28%), Positives = 261/578 (45%), Gaps = 57/578 (9%)
Query: 8 HQQINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTA 67
H ++ VLD ND+SP F + E A+ GT + A D D+G+N+ +T L
Sbjct: 122 HIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENS--LHTYSLSAN 179
Query: 68 DTLNPEDAXXXXXXXXXXVQDVFRIDGRSGA-LLTRASLDREKVARYTVLVKATDQASPV 126
D N E R DG A L+ LDRE + Y + + A+D P
Sbjct: 180 DFFNIEVRT--------------RTDGAKYAELIVVRELDRELKSSYELQLTASDMGVP- 224
Query: 127 SDRLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSA 186
+ S ++ + ++I D NDN P F +++Y + + E+ V ++ + ATD D GAN
Sbjct: 225 --QRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPV--GTLLLDLNATDPDEGANGK 280
Query: 187 IRYAI---IGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQL 243
I Y+ + F IDS G ++L K +DYE +SY + ++AQD G S ++
Sbjct: 281 IVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKI 340
Query: 244 LINIRDVNDNAPRFYTSLF---QESVS---ENVPIGYSIVRVQAYDADEGVNAELTYTMT 297
+I + DVNDN P +L +E +S E PI + V+ D D G+N E+ +
Sbjct: 341 IIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLH 400
Query: 298 DKDYTGNVDLPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXX 357
G+ L T + + + T+ LDRE +++Y L V A D G P S
Sbjct: 401 GH---GHFKLQKTYE-NNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQIN 456
Query: 358 XXXXXXXXFMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRG---RF 412
F +YE ++E+ PG + T+TATD D E+ ++ Y I G
Sbjct: 457 DINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITT 516
Query: 413 SITSQNGRGLITVAQPLDFKQERRYVLTVSATDSGGR----SDTAMVQINITDANNYAPV 468
+T G I + D ++ + V A D G S+T +V + I D N+ PV
Sbjct: 517 YVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVV-LTIIDENDNVPV 575
Query: 469 -----FENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQ 523
N ++ + A G V + A D D G+NA+++ ++ + +
Sbjct: 576 VIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAI-------VAGNEENI 628
Query: 524 FVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
F+I+P++ I TN +D + + L+V +D G P L
Sbjct: 629 FIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQL 666
Score = 184 bits (449), Expect = 3e-45
Identities = 152/498 (30%), Positives = 240/498 (48%), Gaps = 36/498 (7%)
Query: 373 VELAEDEPPGTPVVTLTATDADE-DNRLHYEITGGNTRGRFSI-TSQNGRGL--ITVAQP 428
+E++E GT + +A D D +N LH N + T +G + V +
Sbjct: 144 IEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRE 203
Query: 429 LDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPVFENAPYTASVFEDAPIGT 486
LD + + Y L ++A+D G RS +++++I+I+D+N+ +P FE Y + E++P+GT
Sbjct: 204 LDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGT 263
Query: 487 TVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSG 546
+L ++ATD D G N +I YS SS +S + + + F I+ + G +T K +D E
Sbjct: 264 LLLDLNATDPDEGANGKIVYSFSSHVSPKIM----ETFKIDSERGHLTLFKQVDYEITKS 319
Query: 547 YLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYT------ANIMEDALVGTSV 600
Y + V A+D G S+ + I VVDVNDN+P L + + I E + T V
Sbjct: 320 YEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFV 379
Query: 601 SQVGATDADVGLNGRIHYELDPKDREEGSFVIDPA---SGVIRTNKALDRESVATHDLKA 657
+ V D D GLNG I +L G F + + +I TN LDRE + + L
Sbjct: 380 ALVRVQDKDSGLNGEIVCKL----HGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTV 435
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDEG 717
+A D GTP S+ ++I DIND+PP F+ F ISEN+ G I + A DPD G
Sbjct: 436 IAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLG 495
Query: 718 PNAVVHYSI-KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRA---ASP- 772
N V Y+I + +S + + + D+E + V+ A SP
Sbjct: 496 ENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEV-SQITFVVEARDGGSPK 554
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGP-----FGRVPAYDAD--VTD 825
L ++ V + + D NDN PV+ + N + P G R+ A D D V
Sbjct: 555 QLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNA 614
Query: 826 KLQYRILSGNNANLILLN 843
+L I++GN N+ +++
Sbjct: 615 ELSCAIVAGNEENIFIID 632
Score = 151 bits (367), Expect = 3e-35
Identities = 121/414 (29%), Positives = 196/414 (47%), Gaps = 29/414 (7%)
Query: 455 VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISN 514
+++ + D N+ +P F + + E A +GT + + SA D DVG N+ TYSLS+ N
Sbjct: 123 IEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSA---N 179
Query: 515 EAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDV 574
+ + + + + LDRE S Y L +TA D GVP S ++ ++IS+ D
Sbjct: 180 DFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDS 239
Query: 575 NDNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHY----ELDPKDREEGSF 630
NDN P F+QQ Y ++E++ VGT + + ATD D G NG+I Y + PK E +F
Sbjct: 240 NDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIME--TF 297
Query: 631 VIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESD 690
ID G + K +D E ++++ A D G + + IK+ D+ND+ P +
Sbjct: 298 KIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININ 357
Query: 691 CLT------FYISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSD 744
++ YI E PI T + +R D D G N + + G F L+ + +
Sbjct: 358 LMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHG---HGHFKLQ-KTYEN 413
Query: 745 KAELVTMVDLDYESPRKKYELVIRA---ASPPLWNDVRVEILVTDVNDNAPVMKDFQIIF 801
++T LD E R +Y L + A +P L + + D+NDN P + + F
Sbjct: 414 NYLILTNATLDREK-RSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEF 472
Query: 802 NNYKDCFPVGPFGRVPAYDADVTD--KLQYRILSGNNANLILLNETTGSMTLSP 853
++ P V A D D+ + ++ Y IL + IL + T +T+ P
Sbjct: 473 VISENNSPGAYITTVTATDPDLGENGQVTYTILE----SFILGSSITTYVTIDP 522
>BC038797-1|AAH38797.1| 787|Homo sapiens protocadherin beta 15
protein.
Length = 787
Score = 219 bits (534), Expect = 2e-55
Identities = 180/604 (29%), Positives = 270/604 (44%), Gaps = 30/604 (4%)
Query: 91 RIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRLSSTATIHVNIIDDNDNYPQF 150
++D ++G L+ LDREK+ T Q + + + + D ND+ P+F
Sbjct: 76 QLDLQTGQLILNEKLDREKLCGPTEPCIMHFQV--LLKKPLEVFRAELLVTDINDHSPEF 133
Query: 151 SEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYAIIGGNTQMQFSIDSLSG--- 207
E+ T+ + E S+ V KA D DVG+N+ Y I N+ S +
Sbjct: 134 PEREMTLKIPETSSL--GTVFPLKKARDLDVGSNNVQNYNI-SPNSHFHVSTRTRGDGRK 190
Query: 208 --DVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINIRDVNDNAPRFYTSLFQES 265
++ L LD E+ RL + A DGGSP RS T Q+LI + D NDNAP F +L++
Sbjct: 191 YPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQ 250
Query: 266 VSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVDLPITIDPRSGWVYTSGQLD 325
V EN P+G +V+V A D D G N E++Y++ + +D P + SG + +LD
Sbjct: 251 VPENSPVGSLVVKVSARDLDTGTNGEISYSLYYS--SQEIDKPFELSSLSGEIRLIKKLD 308
Query: 326 RETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXFMPGQYEVELAEDEPPGTPV 385
ET + Y L + A+DGG S + + E+ P T V
Sbjct: 309 FETMSSYDLDIEASDGGG--LSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPE-TEV 365
Query: 386 VTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGLITVAQPLDFKQERRYVLTVSA 443
D D E+ ++ I + + + +N L+T LD + Y +T++
Sbjct: 366 ALFRIRDRDSGENGKMICSIQ-DDVPFKLKPSVENFYRLVTEG-ALDRETRAEYNITITI 423
Query: 444 TDSG-GRSDTAM-VQINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGIN 501
TD G R T + + ++D N+ AP F YT V E+ + V ATD D G N
Sbjct: 424 TDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVRATDRDSGTN 483
Query: 502 AQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSL 561
AQ+TYSL + IN G + + LD E + + V A D G P+L
Sbjct: 484 AQVTYSLLP--PQDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPAL 541
Query: 562 SDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALV------GTSVSQVGATDADVGLNGR 615
S V + V+D NDN P L + LV G V++V A D D G N
Sbjct: 542 SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW 601
Query: 616 IHYELDPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHI 675
+ Y+L K E G F + +G +RT + L VA H L + D G PP+S+T + +
Sbjct: 602 LSYQL-LKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQV 660
Query: 676 KIED 679
+ D
Sbjct: 661 LLVD 664
Score = 197 bits (480), Expect = 5e-49
Identities = 170/585 (29%), Positives = 255/585 (43%), Gaps = 61/585 (10%)
Query: 10 QINVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADT 69
++ V D NDHSP F ++ + E +S GT KA D D+G N Y I
Sbjct: 120 ELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNI------- 172
Query: 70 LNPEDAXXXXXXXXXXVQDVFRIDGRS-GALLTRASLDREKVARYTVLVKATDQASPVSD 128
+P V R DGR L+ LDRE+ A + + A D SP
Sbjct: 173 -SPN--------SHFHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPR- 222
Query: 129 RLSSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIR 188
S T I + ++D NDN P+F + Y V V E+ V ++ K+ A D D G N I
Sbjct: 223 --SGTVQILILVLDANDNAPEFVQALYEVQVPENSPV--GSLVVKVSARDLDTGTNGEIS 278
Query: 189 YAIIGGNTQMQ--FSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLIN 246
Y++ + ++ F + SLSG++ L+K LD+E + SY L I A DGG S + +
Sbjct: 279 YSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGG--GLSGKCSVSVK 336
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ DVNDN P S + EN P + + D D G N ++ ++ D D
Sbjct: 337 VLDVNDNFPELSISSLTSPIPENSP-ETEVALFRIRDRDSGENGKMICSIQD-------D 388
Query: 307 LPITIDPRSGWVY---TSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXX 363
+P + P Y T G LDRET+A+Y + +T TD G P +
Sbjct: 389 VPFKLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNA 448
Query: 364 XXFMPGQYEVELAEDEPPGTPVVTLTATDADE--DNRLHYEITGGN-----TRGRFSITS 416
F Y + + E+ P + ++ ATD D + ++ Y + SI +
Sbjct: 449 PAFTQTSYTLFVRENNSPALHIGSVRATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINT 508
Query: 417 QNGRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITDANNYAPV----FE 470
NG + Q LD++ + + V ATD G S A+V++ + DAN+ +P +
Sbjct: 509 DNGH--LFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQ 566
Query: 471 N--APYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINP 528
N AP T V A G V V A D D G NA ++Y L A F +
Sbjct: 567 NGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK-------ATEPGLFGVWA 619
Query: 529 QTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVD 573
G + T +LL ++ + L V +D G P S T +++ +VD
Sbjct: 620 HNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVD 664
Score = 182 bits (442), Expect = 2e-44
Identities = 147/556 (26%), Positives = 242/556 (43%), Gaps = 30/556 (5%)
Query: 247 IRDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYTMTDKDYTGNVD 306
+ D+ND++P F + E +G +A D D G N Y ++ + +V
Sbjct: 123 VTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHF-HVS 181
Query: 307 LPITIDPRS-GWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXX 365
D R + +LDRE QA+ +L +TA DGG PPRS T
Sbjct: 182 TRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPE 241
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEI--TGGNTRGRFSITSQNGRG 421
F+ YEV++ E+ P G+ VV ++A D D + + Y + + F ++S +G
Sbjct: 242 FVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGE- 300
Query: 422 LITVAQPLDFKQERRYVLTVSATDSGGRSDTAMVQINITDANNYAPVFENAPYTASVFED 481
I + + LDF+ Y L + A+D GG S V + + D N+ P + T+ + E+
Sbjct: 301 -IRLIKKLDFETMSSYDLDIEASDGGGLSGKCSVSVKVLDVNDNFPELSISSLTSPIPEN 359
Query: 482 APIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLLDR 541
+P T V + D D G N ++ S+ ++ + + + + T LDR
Sbjct: 360 SP-ETEVALFRIRDRDSGENGKMICSIQDDVPFKLKPSVENFY-------RLVTEGALDR 411
Query: 542 ETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTSVS 601
ET + Y +T+T D G P L + + V DVNDN P F Q YT + E+ +
Sbjct: 412 ETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIG 471
Query: 602 QVGATDADVGLNGRIHYEL----DPKDREEGSFVIDPASGVIRTNKALDRESVATHDLKA 657
V ATD D G N ++ Y L DP I+ +G + ++LD E++ + +
Sbjct: 472 SVRATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRV 531
Query: 658 VAIDGGTPPQSSTVIVHIKIEDINDSPPVF------ESDCLTFYISENSPIGTTIGEIRA 711
A D G P SS +V + + D ND+ P S T + + G + ++ A
Sbjct: 532 GATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVA 591
Query: 712 HDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDK-AELVTMVDLDYESPRKKYELVIRAA 770
D D G NA + Y + + F + G + A L++ D+ + + LV
Sbjct: 592 VDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDV---AKHRLVVLVKDNG 648
Query: 771 SPPLWNDVRVEILVTD 786
PP +++L+ D
Sbjct: 649 EPPRSATATLQVLLVD 664
Score = 180 bits (438), Expect = 7e-44
Identities = 144/467 (30%), Positives = 223/467 (47%), Gaps = 28/467 (5%)
Query: 366 FMPGQYEVELAEDEPPGTPVVTLTATDAD--EDNRLHYEITGGNTRGRFSITSQNGRGL- 422
F + +++ E GT A D D +N +Y I+ + + T +GR
Sbjct: 133 FPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYP 192
Query: 423 -ITVAQPLDFKQERRYVLTVSATDSGG--RSDTAMVQINITDANNYAPVFENAPYTASVF 479
+ + LD +++ LT++A D G RS T + I + DAN+ AP F A Y V
Sbjct: 193 ELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVP 252
Query: 480 EDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGAITTNKLL 539
E++P+G+ V+ VSA D D G N +I+YSL S++ + D+ F ++ +G I K L
Sbjct: 253 ENSPVGSLVVKVSARDLDTGTNGEISYSL--YYSSQEI---DKPFELSSLSGEIRLIKKL 307
Query: 540 DRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIMEDALVGTS 599
D ETMS Y L + A DGG LS V + V+DVNDN P T+ I E++ T
Sbjct: 308 DFETMSSYDLDIEASDGG--GLSGKCSVSVKVLDVNDNFPELSISSLTSPIPENS-PETE 364
Query: 600 VSQVGATDADVGLNGRIHYELDPKDREEGSFVIDPA-SGVIR--TNKALDRESVATHDLK 656
V+ D D G NG++ + +++ F + P+ R T ALDRE+ A +++
Sbjct: 365 VALFRIRDRDSGENGKMICSI----QDDVPFKLKPSVENFYRLVTEGALDRETRAEYNIT 420
Query: 657 AVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTTIGEIRAHDPDE 716
D GTP + + + + D+ND+ P F T ++ EN+ IG +RA D D
Sbjct: 421 ITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVRATDRDS 480
Query: 717 GPNAVVHYSIKGGDDSN-SFSLETRQGSDKAELVTMVDLDYESPRKKYELVIRAAS---P 772
G NA V YS+ D + + +D L + LDYE+ + +E + A P
Sbjct: 481 GTNAQVTYSLLPPQDPHLPLTSLVSINTDNGHLFALQSLDYEA-LQAFEFRVGATDRGFP 539
Query: 773 PLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVGPFGRVPAY 819
L ++ V +LV D NDN+P + + N C + P P Y
Sbjct: 540 ALSSEALVRVLVLDANDNSPFV--LYPLQNGSAPCTELVPRAAEPGY 584
Score = 162 bits (394), Expect = 1e-38
Identities = 133/427 (31%), Positives = 194/427 (45%), Gaps = 22/427 (5%)
Query: 456 QINITDANNYAPVFENAPYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNE 515
++ +TD N+++P F T + E + +GT + A D DVG N Y++S
Sbjct: 120 ELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFH 179
Query: 516 AVAHHDQQFVINPQTGAITTNKLLDRETMSGYLLTVTARDGGVPSLSDTTDVEISVVDVN 575
P+ + + LDRE + LT+TA DGG P S T + I V+D N
Sbjct: 180 VSTRTRGDGRKYPE---LVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDAN 236
Query: 576 DNEPVFKQQLYTANIMEDALVGTSVSQVGATDADVGLNGRIHYELDPKDRE-EGSFVIDP 634
DN P F Q LY + E++ VG+ V +V A D D G NG I Y L +E + F +
Sbjct: 237 DNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSS 296
Query: 635 ASGVIRTNKALDRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTF 694
SG IR K LD E+++++DL A DGG S V +K+ D+ND+ P LT
Sbjct: 297 LSGEIRLIKKLDFETMSSYDLDIEASDGG--GLSGKCSVSVKVLDVNDNFPELSISSLTS 354
Query: 695 YISENSPIGTTIGEIRAHDPDEGPNAVVHYSIKGGDDSNSFSLETRQGSDKAELVTMVDL 754
I ENSP T + R D D G N + SI+ D F L+ + LVT L
Sbjct: 355 PIPENSP-ETEVALFRIRDRDSGENGKMICSIQ---DDVPFKLKP-SVENFYRLVTEGAL 409
Query: 755 DYESPRKKYELVIR---AASPPLWNDVRVEILVTDVNDNAPVMKDFQIIFNNYKDCFPVG 811
D E+ R +Y + I +P L + + +LV+DVNDNAP ++ P
Sbjct: 410 DRET-RAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPAL 468
Query: 812 PFGRVPAYDAD--VTDKLQYRILSGNN-----ANLILLNETTGSMTLSPQLNTNVPKLAT 864
G V A D D ++ Y +L + +L+ +N G + L+ +
Sbjct: 469 HIGSVRATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFE 528
Query: 865 MEVSVTD 871
V TD
Sbjct: 529 FRVGATD 535
Score = 134 bits (324), Expect = 4e-30
Identities = 130/482 (26%), Positives = 206/482 (42%), Gaps = 46/482 (9%)
Query: 11 INVLDCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVTADTL 70
I VLD ND++P F YE V E + G+ V+ + A D D G N E+ Y++ + +
Sbjct: 230 ILVLDANDNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEID 289
Query: 71 NPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPVSDRL 130
P F + SG + LD E ++ Y + ++A+D L
Sbjct: 290 KP-----------------FELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGG-----L 327
Query: 131 SSTATIHVNIIDDNDNYPQFSEKTYTVSVDEDISVTDNPVIAKIKATDADVGANSAIRYA 190
S ++ V ++D NDN+P+ S + T + E+ T+ +A + D D G N + +
Sbjct: 328 SGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETE---VALFRIRDRDSGENGKMICS 384
Query: 191 IIGGNTQMQFSID-SLSGDVSLVK--TLDYEQVRSYRLVIRAQDGGSPSRSNTTQLLINI 247
I + F + S+ LV LD E Y + I D G+P + + +
Sbjct: 385 I---QDDVPFKLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLV 441
Query: 248 RDVNDNAPRFYTSLFQESVSENVPIGYSIVRVQAYDADEGVNAELTYT-MTDKDYTGNVD 306
DVNDNAP F + + V EN I V+A D D G NA++TY+ + +D +
Sbjct: 442 SDVNDNAPAFTQTSYTLFVRENNSPALHIGSVRATDRDSGTNAQVTYSLLPPQDPHLPLT 501
Query: 307 LPITIDPRSGWVYTSGQLDRETQAKYQLLVTATDGGDPPRSATATXXXXXXXXXXXXXXF 366
++I+ +G ++ LD E ++ V ATD G P S+ A
Sbjct: 502 SLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFV 561
Query: 367 M-PGQY-EVELAEDEP----PGTPVVTLTATDADEDNR--LHYEITGGNTRGRFSITSQN 418
+ P Q E P PG V + A D D L Y++ G F + + N
Sbjct: 562 LYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHN 621
Query: 419 GRGLITVAQPLDFKQERRYVLTVSATDSG--GRSDTAMVQINITD--ANNYAPVFENAPY 474
G + A+ L + ++ L V D+G RS TA +Q+ + D + Y P+ E AP
Sbjct: 622 GE--VRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVDGFSQPYLPLPEAAPA 679
Query: 475 TA 476
A
Sbjct: 680 QA 681
Score = 111 bits (267), Expect = 3e-23
Identities = 97/330 (29%), Positives = 150/330 (45%), Gaps = 24/330 (7%)
Query: 473 PYTASVFEDAPIGTTVLVVSATDSDVGINAQITYSLSSEISNEAVAHHDQQFVINPQTGA 532
P SV E+ G+ V ++ +D+G+ + + +E ++Q ++ QTG
Sbjct: 30 PRRYSVMEETERGSFVANLA---NDLGLGVGELAERGARVVSE---DNEQGLQLDLQTGQ 83
Query: 533 ITTNKLLDRETMSGYL-LTVTARDGGVPSLSDTTDVEISVVDVNDNEPVFKQQLYTANIM 591
+ N+ LDRE + G + + + E+ V D+ND+ P F ++ T I
Sbjct: 84 LILNEKLDREKLCGPTEPCIMHFQVLLKKPLEVFRAELLVTDINDHSPEFPEREMTLKIP 143
Query: 592 EDALVGTSVSQVGATDADVGLNGRIHYELDPKD------REEGSFVIDPASGVIRTNKAL 645
E + +GT A D DVG N +Y + P R G P V+ T L
Sbjct: 144 ETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPEL-VLDTE--L 200
Query: 646 DRESVATHDLKAVAIDGGTPPQSSTVIVHIKIEDINDSPPVFESDCLTFYISENSPIGTT 705
DRE A L A+DGG+PP+S TV + I + D ND+ P F + ENSP+G+
Sbjct: 201 DREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVGSL 260
Query: 706 IGEIRAHDPDEGPNAVVHYSI--KGGDDSNSFSLETRQGSDKAELVTMVDLDYESPRKKY 763
+ ++ A D D G N + YS+ + F L + G E+ + LD+E+ Y
Sbjct: 261 VVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSG----EIRLIKKLDFET-MSSY 315
Query: 764 ELVIRAA-SPPLWNDVRVEILVTDVNDNAP 792
+L I A+ L V + V DVNDN P
Sbjct: 316 DLDIEASDGGGLSGKCSVSVKVLDVNDNFP 345
Score = 95.1 bits (226), Expect = 3e-18
Identities = 73/247 (29%), Positives = 115/247 (46%), Gaps = 23/247 (9%)
Query: 9 QQINVL--DCNDHSPVFEMQQYEASVREGASSGTTVLTLKATDQDIGKNAEVEYTIELVT 66
Q I VL D ND++P F Y VRE S + +++ATD+D G NA+V Y++
Sbjct: 435 QSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVRATDRDSGTNAQVTYSL---- 490
Query: 67 ADTLNPEDAXXXXXXXXXXVQDVFRIDGRSGALLTRASLDREKVARYTVLVKATDQASPV 126
L P+D + + I+ +G L SLD E + + V ATD+ P
Sbjct: 491 ---LPPQDPHLP-------LTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPA 540
Query: 127 SDRLSSTATIHVNIIDDNDNYP--QFSEKTYTVSVDEDISVTDNP--VIAKIKATDADVG 182
LSS A + V ++D NDN P + + + E + P ++ K+ A D D G
Sbjct: 541 ---LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSG 597
Query: 183 ANSAIRYAIIGGNTQMQFSIDSLSGDVSLVKTLDYEQVRSYRLVIRAQDGGSPSRSNTTQ 242
N+ + Y ++ F + + +G+V + L V +RLV+ +D G P RS T
Sbjct: 598 QNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATAT 657
Query: 243 LLINIRD 249
L + + D
Sbjct: 658 LQVLLVD 664
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.317 0.134 0.404
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 409,526,410
Number of Sequences: 224733
Number of extensions: 18228345
Number of successful extensions: 86829
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 947
Number of HSP's successfully gapped in prelim test: 677
Number of HSP's that attempted gapping in prelim test: 40717
Number of HSP's gapped (non-prelim): 19040
length of query: 2796
length of database: 73,234,838
effective HSP length: 103
effective length of query: 2693
effective length of database: 50,087,339
effective search space: 134885203927
effective search space used: 134885203927
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 74 (33.9 bits)
- SilkBase 1999-2023 -