Silkworm BLAST Result against human

BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA000368-TA|BGIBMGA000368-PA|IPR001128|Cytochrome P450,
IPR002403|E-class P450, group IV
         (517 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

AL138805-3|CAB91829.1|  514|Homo sapiens cytochrome P450, family...   182   3e-45
L13286-1|AAA62379.1|  513|Homo sapiens 1,25-dihydroxyvitamin D3 ...   171   4e-42
M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase pro...   158   5e-38
BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family...   158   5e-38
BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family...   158   5e-38
X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase...   157   1e-37
AY178622-1|AAO21126.1|  531|Homo sapiens steroid hydroxylase pro...   156   2e-37
X05367-1|CAA28965.1|  521|Homo sapiens desmolase protein.             155   3e-37
M14565-1|AAA52162.1|  521|Homo sapiens CYP11A protein.                154   8e-37
BC032329-1|AAH32329.1|  521|Homo sapiens cytochrome P450, family...   154   8e-37
AY288916-1|AAP31972.1|  508|Homo sapiens cytochrome P450, family...   153   1e-36
AF256213-1|AAG00416.1|  508|Homo sapiens 25- hydroxyvitamin D-1-...   153   1e-36
AF246895-1|AAF64299.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...   153   1e-36
AF027152-1|AAC51854.1|  508|Homo sapiens P450 25-hydroxyvitamin ...   153   1e-36
AF020192-1|AAC51853.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...   153   1e-36
AB006987-1|BAA23418.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...   153   1e-36
AB005990-1|BAA22657.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...   153   1e-36
AB005989-1|BAA22656.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...   153   1e-36
AB005038-1|BAA23416.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...   153   1e-36
AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylas...   148   5e-35
AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family...   148   5e-35
BC039307-1|AAH39307.1|  372|Homo sapiens FLJ16008 protein protein.    138   4e-32
AK131190-1|BAD18388.1|  372|Homo sapiens .-.-).  protein.             138   4e-32
J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3 prot...   130   2e-29
BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family...   130   2e-29
AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.             130   2e-29
BC109084-1|AAI09085.1|  448|Homo sapiens CYP24A1 protein protein.     128   5e-29
BC109083-1|AAI09084.1|  448|Homo sapiens CYP24A1 protein protein.     128   5e-29
AL138805-2|CAM27343.1|  448|Homo sapiens cytochrome P450, family...   128   5e-29
AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family...   127   8e-29
AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43...   126   1e-28
AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfami...   126   1e-28
AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43...   126   1e-28
AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfami...   126   1e-28
AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.             126   1e-28
S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D 24-hy...   125   3e-28
M28253-1|AAA36404.1|  239|Homo sapiens cytochrome P-450-scc prot...   124   6e-28
AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43...   123   1e-27
AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfami...   122   2e-27
AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.             122   2e-27
D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa pro...   120   9e-27
BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family...   120   9e-27
AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant...   120   9e-27
AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450 polypep...   120   9e-27
M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA...   119   3e-26
DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family ...   119   3e-26
DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family...   119   3e-26
BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfam...   119   3e-26
BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family...   119   3e-26
AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.     119   3e-26
AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450 polypep...   119   3e-26
AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4 p...   119   3e-26
AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4 pro...   119   3e-26
X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for ...   118   5e-26
X55764-1|CAA39290.1|  503|Homo sapiens protein ( Human mRNA for ...   118   7e-26
M32879-1|AAA52149.1|  503|Homo sapiens CYP11B1 protein.               117   1e-25
M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrom...   117   1e-25
BC096287-1|AAH96287.1|  503|Homo sapiens cytochrome P450, family...   117   1e-25
J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipin...   116   2e-25
AF478474-1|AAL84813.1|  503|Homo sapiens mutated cytochrome P-45...   116   2e-25
M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver glu...   115   4e-25
D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.      115   4e-25
D13752-1|BAA02899.1|  503|Homo sapiens steroid 18-hydroxylase pr...   114   6e-25
AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.     113   2e-24
AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.     113   2e-24
X54741-1|CAA38539.1|  503|Homo sapiens aldosterone  synthase (P-...   112   2e-24
M32881-1|AAA35741.1|  503|Homo sapiens protein ( Human steroid 1...   110   1e-23
BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.     109   2e-23
BC096285-1|AAH96285.1|  574|Homo sapiens CYP11B1 protein protein.     106   2e-22
BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family...   101   5e-21
AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2 pro...   101   5e-21
AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens ...   101   5e-21
AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens ...   101   5e-21
BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family...    97   1e-19
AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxyl...    97   1e-19
AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfami...    95   7e-19
AY280372-1|AAQ21368.1|  519|Homo sapiens cytochrome P450 4A22 pr...    92   5e-18
S67581-1|AAB29503.1|  591|Homo sapiens fatty acid omega-hydroxyl...    91   9e-18
S67580-1|AAB29502.1|  519|Homo sapiens fatty acid omega-hydroxyl...    91   9e-18
L04751-1|AAA58436.1|  519|Homo sapiens cytochrome P450 protein.        90   2e-17
D26481-1|BAA05491.1|  519|Homo sapiens fatty acids omega-hydroxy...    90   2e-17
AY369778-1|AAQ56847.1|  519|Homo sapiens cytochrome P450, family...    90   2e-17
AL731892-3|CAH72778.1|  519|Homo sapiens cytochrome P450, family...    90   2e-17
AJ563378-3|CAD91347.1|  173|Homo sapiens hypothetical protein pr...    90   2e-17
AJ563378-2|CAD91647.1|  160|Homo sapiens cytochrome P450 protein.      90   2e-17
AF525488-1|AAO16078.1|  519|Homo sapiens cytochrome P450, subfam...    89   3e-17
AY280371-1|AAQ21367.1|  519|Homo sapiens cytochrome P450 4A22K p...    89   3e-17
AF208532-1|AAF76722.1|  519|Homo sapiens fatty acid omega-hydrox...    87   1e-16
M24667-1|AAA52148.1|  256|Homo sapiens steroid 11-beta-hydroxyla...    87   1e-16
BC028102-1|AAH28102.1|  509|Homo sapiens cytochrome P450, family...    87   1e-16
AY358537-1|AAQ88901.1|  509|Homo sapiens EFSW1929 protein.             87   1e-16
AM040940-1|CAJ13826.1|  509|Homo sapiens cytochrome P450 protein.      87   1e-16
AL450996-1|CAH71035.1|  509|Homo sapiens cytochrome P450, family...    87   1e-16
AK098065-1|BAC05226.1|  509|Homo sapiens protein ( Homo sapiens ...    87   1e-16
AK091806-1|BAC03751.1|  444|Homo sapiens protein ( Homo sapiens ...    87   1e-16
AK131355-1|BAD18508.1|  508|Homo sapiens protein ( Homo sapiens ...    87   2e-16
AL135960-10|CAI19737.1|  519|Homo sapiens cytochrome P450, famil...    86   2e-16
BC016853-1|AAH16853.1|  524|Homo sapiens CYP4F11 protein protein.      83   2e-15
AY792513-1|AAV40834.1|  520|Homo sapiens cytochrome P450, family...    83   2e-15
AF236085-1|AAG15889.1|  524|Homo sapiens CYP4F11 protein.              83   2e-15
AF054821-1|AAC08589.1|  520|Homo sapiens cytochrome P-450 protein.     83   2e-15
D13705-1|BAA02864.1|  521|Homo sapiens fatty acid omega-hydroxyl...    83   2e-15
D12620-1|BAA02144.1|  520|Homo sapiens cytochrome P-450LTBV prot...    83   2e-15
BC035959-1|AAH35959.1|  503|Homo sapiens cytochrome P450, family...    83   2e-15
AB002461-1|BAA25991.1|  520|Homo sapiens leukotriene B4 omega-hy...    83   2e-15
AB002454-1|BAA25990.1|  520|Homo sapiens leukotriene B4 omega-hy...    83   2e-15
M28420-1|AAA52141.1|  419|Homo sapiens cytochrome P-450 aromatas...    83   3e-15
J04127-1|AAA52132.1|  503|Homo sapiens CYP19 protein.                  83   3e-15
BC067440-1|AAH67440.1|  520|Homo sapiens cytochrome P450, family...    83   3e-15
AB015306-1|BAA75823.1|  520|Homo sapiens Leukotriene B4 omega-hy...    83   3e-15
Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for ...    82   4e-15
X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for ...    82   4e-15
M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase...    82   4e-15
M22246-1|AAA35557.1|  503|Homo sapiens protein ( Human aromatase...    82   4e-15
M18856-1|AAA35556.1|  419|Homo sapiens protein ( Human aromatase...    82   4e-15
D26480-1|BAA05490.1|  520|Homo sapiens leukotriene B4 omega-hydr...    82   4e-15
DQ118405-1|AAZ23558.1|  503|Homo sapiens cytochrome P450 subfami...    82   4e-15
BC067439-1|AAH67439.1|  520|Homo sapiens cytochrome P450, family...    82   4e-15
BC067437-1|AAH67437.1|  520|Homo sapiens cytochrome P450, family...    82   4e-15
BC035350-1|AAH35350.1|  524|Homo sapiens cytochrome P450, family...    82   4e-15
AY957953-1|AAX44046.1|  503|Homo sapiens cytochrome P450, family...    82   4e-15
AY358977-1|AAQ89336.1|  524|Homo sapiens CYP4F12 protein.              82   4e-15
AY008841-1|AAG33247.1|  524|Homo sapiens cytochrome P450 isoform...    82   4e-15
AF467894-1|AAL67578.1|  520|Homo sapiens cytochrome P450, subfam...    82   4e-15
AC005336-1|AAC27730.1|  520|Homo sapiens CYP4F2 protein.               82   4e-15
AC004523-1|AAC11543.1|  458|Homo sapiens F22329_1 protein.             82   4e-15
AB035131-1|BAB18270.1|  524|Homo sapiens cytochrome P450 protein.      82   4e-15
AB035130-1|BAB18269.1|  524|Homo sapiens cytochrome P450 protein.      82   4e-15
U02388-1|AAC50052.2|  520|Homo sapiens cytochrome P450 4F2 protein.    82   5e-15
BC107785-1|AAI07786.1|  503|Homo sapiens cytochrome P450, family...    82   5e-15
U23942-1|AAB39951.1|  509|Homo sapiens lanosterol 14-demethylase...    81   7e-15
D55653-1|BAA09512.1|  509|Homo sapiens lanosterol 14-demethylase...    81   7e-15
BC032322-1|AAH32322.1|  509|Homo sapiens cytochrome P450, family...    81   7e-15
AF233623-1|AAF99277.1|  534|Homo sapiens thromboxane synthase pr...    81   7e-15
AC000120-2|AAB46356.1|  509|Homo sapiens unknown protein.              81   7e-15
M80647-1|AAA60618.1|  534|Homo sapiens thromboxane synthase prot...    81   9e-15
BC041157-1|AAH41157.1|  534|Homo sapiens thromboxane A synthase ...    81   9e-15
BC014117-1|AAH14117.1|  466|Homo sapiens TBXAS1 protein protein.       81   9e-15
AK223466-1|BAD97186.1|  534|Homo sapiens thromboxane A synthase ...    81   9e-15
AF233625-1|AAF99279.1|  534|Homo sapiens thromboxane synthase pr...    81   9e-15
AF233622-1|AAF99276.1|  534|Homo sapiens thromboxane synthase pr...    81   9e-15
AF233621-1|AAF99275.1|  534|Homo sapiens thromboxane synthase pr...    81   9e-15
AF233620-1|AAF99274.1|  534|Homo sapiens thromboxane synthase pr...    81   9e-15
AF233619-1|AAF99273.1|  534|Homo sapiens thromboxane synthase pr...    81   9e-15
AF233618-1|AAF99272.1|  534|Homo sapiens thromboxane synthase pr...    81   9e-15
AF233617-1|AAF99271.1|  534|Homo sapiens thromboxane synthase pr...    81   9e-15
AF233616-1|AAF99270.1|  534|Homo sapiens thromboxane synthase pr...    81   9e-15
AF233615-1|AAF99269.1|  534|Homo sapiens thromboxane synthase pr...    81   9e-15
AF133298-1|AAD49566.1|  520|Homo sapiens cytochrome P450 protein.      81   9e-15
U51692-1|AAC50951.1|  503|Homo sapiens lanosterol 14-alpha demet...    80   2e-14
D34625-1|BAA07011.1|  533|Homo sapiens thromboxane synthase prot...    79   4e-14
AY358631-1|AAQ88994.1|  505|Homo sapiens EPSW3060 protein.             79   4e-14
AY262056-1|AAO89257.1|  505|Homo sapiens cytochrome P450 protein.      79   4e-14
AL450996-2|CAH71036.1|  505|Homo sapiens cytochrome P450, family...    79   4e-14
AL135960-6|CAI19734.1|  505|Homo sapiens cytochrome P450, family...    79   4e-14
AK090886-1|BAC03539.1|  337|Homo sapiens protein ( Homo sapiens ...    79   4e-14
AF233624-1|AAF99278.1|  534|Homo sapiens thromboxane synthase pr...    79   4e-14
BC041158-1|AAH41158.1|  455|Homo sapiens CYP4A11 protein protein.      79   5e-14
AL731892-4|CAH72779.1|  455|Homo sapiens cytochrome P450, family...    79   5e-14
BC100982-1|AAI00983.1|  280|Homo sapiens CYP3A43 protein protein.      78   9e-14
BC096286-1|AAH96286.1|  437|Homo sapiens cytochrome P450, family...    77   1e-13
AL358613-3|CAH72804.1|  428|Homo sapiens cytochrome P450, family...    77   2e-13
AL358613-2|CAH72803.1|  497|Homo sapiens cytochrome P450, family...    77   2e-13
AF005418-1|AAB88881.1|  497|Homo sapiens retinoic acid hydroxyla...    77   2e-13
BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family...    75   5e-13
BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family...    75   5e-13
AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1 pro...    75   5e-13
AL135960-11|CAI19738.1|  455|Homo sapiens cytochrome P450, famil...    75   5e-13
BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family...    73   2e-12
AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.      73   2e-12
M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.                  73   3e-12
M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.                  73   3e-12
M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.                  73   3e-12
M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.                  73   3e-12
DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family...    73   3e-12
BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family...    73   3e-12
BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family...    73   3e-12
BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family...    73   3e-12
AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family...    73   3e-12
X71480-1|CAA50586.1|  141|Homo sapiens cytochrome P450 protein.        72   6e-12
BC093896-1|AAH93896.1|  531|Homo sapiens cytochrome P450, family...    72   6e-12
BC093894-1|AAH93894.1|  531|Homo sapiens cytochrome P450, family...    72   6e-12
BC069351-1|AAH69351.1|  531|Homo sapiens cytochrome P450, family...    72   6e-12
AK096820-1|BAC04868.1|  531|Homo sapiens protein ( Homo sapiens ...    72   6e-12
AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family...    70   2e-11
U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450 monooxyge...    70   2e-11
BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family...    70   2e-11
AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family...    70   2e-11
AF491285-1|AAM09532.1|  511|Homo sapiens cytochrome P450 protein.      70   2e-11
AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.      70   2e-11
AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,...    69   3e-11
AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2 pro...    69   3e-11
X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase ...    69   4e-11
M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant 21...    69   4e-11
M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human 21-hydrox...    69   4e-11
M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.                  69   4e-11
M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.                 69   4e-11
BX679671-8|CAM26071.1|  464|Homo sapiens cytochrome P450, family...    69   4e-11
BX679671-7|CAM26070.1|  494|Homo sapiens cytochrome P450, family...    69   4e-11
BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family...    69   4e-11
BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family...    69   4e-11
AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,...    69   4e-11
AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,...    69   4e-11
AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,...    69   4e-11
AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,...    69   4e-11
AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,...    69   4e-11
AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,...    69   4e-11
AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family...    69   4e-11
AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family...    69   4e-11
AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, famil...    69   4e-11
AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, famil...    69   4e-11
AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, famil...    69   4e-11
AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, famil...    69   4e-11
AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P4...    69   4e-11
AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens ...    69   4e-11
AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450 21-hydr...    69   4e-11
AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450 21-hydr...    69   4e-11
X16699-1|CAA34672.1|  511|Homo sapiens protein ( Human mRNA for ...    69   5e-11
J02871-1|AAA35712.1|  511|Homo sapiens protein ( Human lung cyto...    69   5e-11
DQ518907-1|ABF47106.1|  511|Homo sapiens cytochrome P450, family...    69   5e-11
BC017758-1|AAH17758.1|  512|Homo sapiens cytochrome P450, family...    69   5e-11
AY151049-1|AAN72312.1|  497|Homo sapiens pulmonary cytochrome P4...    69   5e-11
AY151048-1|AAN72311.1|  512|Homo sapiens pulmonary cytochrome P4...    69   5e-11
AY064485-1|AAL57720.1|  511|Homo sapiens cytochrome P450 protein.      69   5e-11
AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,...    69   5e-11
AL593856-7|CAI16983.1|  497|Homo sapiens cytochrome P450, family...    69   5e-11
AL593856-6|CAI16982.1|  512|Homo sapiens cytochrome P450, family...    69   5e-11
AL593856-5|CAI16981.1|  511|Homo sapiens cytochrome P450, family...    69   5e-11
AL356793-4|CAI22559.1|  511|Homo sapiens cytochrome P450, family...    69   5e-11
AL356793-3|CAI22557.1|  512|Homo sapiens cytochrome P450, family...    69   5e-11
AL356793-2|CAI22558.1|  497|Homo sapiens cytochrome P450, family...    69   5e-11
X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.                68   7e-11
EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family...    68   7e-11
BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family...    68   7e-11
AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1 var...    68   7e-11
AY064486-1|AAL57721.1|  511|Homo sapiens cytochrome P450 protein.      68   7e-11
AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1 pro...    68   7e-11
AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family...    68   7e-11
AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.      68   7e-11
X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.    68   9e-11
K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.                 68   9e-11
M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.                  67   1e-10
M12079-1|AAA52152.1|  191|Homo sapiens POR protein.                    67   1e-10
AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase ...    67   2e-10
M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase pr...    66   2e-10
BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family...    62   3e-09
BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family...    62   3e-09
M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.                  62   6e-09
AF237982-1|AAF63329.1|  469|Homo sapiens oxysterol 7alpha-hydrox...    61   1e-08
BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family...    60   2e-08
X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for ...    60   2e-08
Z00036-1|CAA77335.1|  515|Homo sapiens protein ( Human mRNA for ...    59   3e-08
X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mR...    59   3e-08
X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is ...    59   3e-08
M55053-1|AAA52146.1|  515|Homo sapiens cytochrome P3-450 protein.      59   3e-08
M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.                  59   3e-08
M31667-1|AAA52163.1|  515|Homo sapiens CYP1A2 protein.                 59   3e-08
M12078-1|AAA52154.1|  192|Homo sapiens POR protein.                    59   3e-08
L00389-1|AAA35738.1|  516|Homo sapiens protein ( Human cytochrom...    59   3e-08
DQ022432-1|AAY26399.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family...    59   3e-08
BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family...    59   3e-08
BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family...    59   3e-08
BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family...    59   3e-08
BC067428-1|AAH67428.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC067427-1|AAH67427.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC067426-1|AAH67426.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC067425-1|AAH67425.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC067424-1|AAH67424.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC033691-1|AAH33691.1|  504|Homo sapiens cytochrome P450, family...    59   3e-08
BC010358-1|AAH10358.1|  469|Homo sapiens cytochrome P450, family...    59   3e-08
AY358603-1|AAQ88966.1|  504|Homo sapiens Cytochrome p450 protein.      59   3e-08
AK027605-1|BAB55227.1|  564|Homo sapiens protein ( Homo sapiens ...    59   3e-08
AF335278-1|AAK13498.1|  504|Homo sapiens cytochrome P450 2S1 pro...    59   3e-08
AF253322-2|AAK25728.1|  516|Homo sapiens cytochrome P450 protein.      59   3e-08
AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6 pro...    59   3e-08
J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrom...    59   4e-08
J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrom...    59   4e-08
DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family...    59   4e-08
DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1 pro...    59   4e-08
AL591242-1|CAH73899.1|  469|Homo sapiens cytochrome P450, family...    59   4e-08
AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family...    59   4e-08
AL035670-1|CAI20276.1|  469|Homo sapiens cytochrome P450, family...    59   4e-08
AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1 pro...    59   4e-08
AF182274-1|AAF13599.1|  516|Homo sapiens cytochrome P450-1A2 pro...    59   4e-08
AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1 pro...    59   4e-08
BC109205-1|AAI09206.1|  512|Homo sapiens cytochrome P450, family...    58   6e-08
BC069443-1|AAH69443.1|  512|Homo sapiens cytochrome P450, family...    58   6e-08
BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family...    58   6e-08
AF252297-1|AAF76003.1|  512|Homo sapiens cytochrome P450 retinoi...    58   6e-08
AC007002-1|AAY14690.1|  512|Homo sapiens unknown protein.              58   6e-08
DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   7e-08
DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   7e-08
M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6 prot...    58   1e-07
M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoqu...    58   1e-07
M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.     58   1e-07
DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6 pro...    58   1e-07
CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.               58   1e-07
BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family...    58   1e-07
BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family...    58   1e-07
BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family...    58   1e-07
BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family...    58   1e-07
BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family...    58   1e-07
BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family...    58   1e-07
BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.       58   1e-07
AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6 prot...    58   1e-07
AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxyl...    58   1e-07
AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13 va...    57   1e-07
AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13 va...    57   1e-07
AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13 va...    57   1e-07
AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13 va...    57   1e-07
AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13 va...    57   1e-07
AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13 pr...    57   1e-07
X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.    57   2e-07
M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.                  57   2e-07
M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrom...    57   2e-07
AL135960-9|CAI19736.1|  421|Homo sapiens cytochrome P450, family...    56   2e-07
U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.        56   3e-07
M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.             56   3e-07
Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.                   56   4e-07
M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.                  56   4e-07
L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.        56   4e-07
BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family...    56   4e-07
AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family...    56   4e-07
AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family...    56   4e-07
AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family...    56   4e-07
AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family...    56   4e-07
AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family...    56   4e-07
M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.                  55   7e-07
AY220845-1|AAO49806.1|  516|Homo sapiens cytochrome P450 protein.      55   7e-07
U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.        54   9e-07
AL358613-1|CAH72802.2|  522|Homo sapiens cytochrome P450, family...    54   9e-07
M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.                54   1e-06
M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.             54   1e-06
BX538127-1|CAD98029.1|  310|Homo sapiens hypothetical protein pr...    54   1e-06
BC096260-1|AAH96260.1|  431|Homo sapiens CYP2C18 protein protein.      54   1e-06
BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family...    54   1e-06
BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family...    54   1e-06
BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family...    54   1e-06
AY356349-1|AAQ55485.1|  522|Homo sapiens cytochrome P450 protein.      54   1e-06
AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family...    54   1e-06
AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family...    54   1e-06
X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120...    54   2e-06
AM233517-1|CAJ80720.1|  175|Homo sapiens cytochrome P450 1A1 pro...    54   2e-06
L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxyla...    53   3e-06
AF372573-1|AAL69652.1|  495|Homo sapiens cytochrome P450 2F1 pro...    53   3e-06
J02906-1|AAA52156.1|  491|Homo sapiens CYP2F1 protein.                 52   4e-06
X56088-1|CAA39568.1|  504|Homo sapiens cholesterol  7-alpha-hydr...    52   5e-06
U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.        52   5e-06
M80646-1|AAA60617.1|  460|Homo sapiens thromboxane synthase prot...    52   5e-06
S77409-1|AAB34643.1|  228|Homo sapiens steroid 18-hydroxylase pr...    52   6e-06
L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18 prot...    52   6e-06
X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C pro...    51   9e-06
M29874-1|AAA52144.1|  491|Homo sapiens CYP2B protein.                  51   1e-05
DQ298753-1|ABB84469.1|  491|Homo sapiens cytochrome P450, family...    51   1e-05
BC067431-1|AAH67431.1|  491|Homo sapiens cytochrome P450, family...    51   1e-05
BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family...    51   1e-05
AC023172-1|AAF32444.1|  491|Homo sapiens CYP2B6 protein.               51   1e-05
M93133-1|AAA58435.1|  504|Homo sapiens cholesterol 7-alpha hydro...    50   1e-05
K03192-1|AAA52147.1|  331|Homo sapiens CYP1A1 protein.                 50   1e-05
DQ680079-1|ABG25922.1|  347|Homo sapiens truncated cytochrome P4...    50   1e-05
BC112184-1|AAI12185.1|  504|Homo sapiens cytochrome P450, family...    50   1e-05
BC101777-1|AAI01778.1|  504|Homo sapiens cytochrome P450, family...    50   1e-05
BC067430-1|AAH67430.1|  491|Homo sapiens cytochrome P450, family...    50   2e-05
AF182277-1|AAF13602.1|  491|Homo sapiens cytochrome P450-2B6 pro...    50   2e-05
M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.                  49   3e-05
M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.                  49   3e-05
S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.       49   5e-05
M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.                  49   5e-05
D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.       49   5e-05
BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family...    49   5e-05
AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family...    49   5e-05
AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family...    49   5e-05
AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family...    49   5e-05
AM233518-1|CAJ80721.1|  157|Homo sapiens cytochrome P450 1A1 pro...    48   1e-04
AF040259-1|AAD10199.1|  144|Homo sapiens cytochrome P450 1A1 pro...    48   1e-04
BC128535-1|AAI28536.1|  143|Homo sapiens LOC283480 protein protein.    46   2e-04
AJ563379-2|CAD91649.1|   84|Homo sapiens cytochrome P450 protein.      46   2e-04
AB209700-1|BAD92937.1|  336|Homo sapiens cytochrome P450, family...    44   0.001
L36085-1|AAC01761.1|  441|Homo sapiens thromboxane A2 synthase p...    44   0.001
AK127151-1|BAC86855.1|  146|Homo sapiens protein ( Homo sapiens ...    44   0.001
AK127234-1|BAC86895.1|  130|Homo sapiens ).  protein.                  44   0.002
D12621-1|BAA02145.1|  389|Homo sapiens cytochrome P-450LTBV prot...    43   0.002
AK094090-1|BAC04283.1|  153|Homo sapiens protein ( Homo sapiens ...    43   0.003
AJ877238-1|CAI47002.1|   97|Homo sapiens putative cytochrome P45...    42   0.004
BC001776-1|AAH01776.1|  217|Homo sapiens CYP27B1 protein protein.      42   0.005
U56438-1|AAC50809.1|  543|Homo sapiens dioxin-inducible cytochro...    42   0.007
U03688-1|AAA19567.1|  543|Homo sapiens cytochrome P450 protein.        42   0.007
BT020001-1|AAV38804.1|  543|Homo sapiens cytochrome P450, family...    42   0.007
BT019979-1|AAV38782.1|  543|Homo sapiens cytochrome P450, family...    42   0.007
BC012049-1|AAH12049.1|  543|Homo sapiens cytochrome P450, family...    42   0.007
AY393998-1|AAQ87875.1|  543|Homo sapiens cytochrome P450, family...    42   0.007
AF450132-1|AAM50512.1|  543|Homo sapiens cytochrome P450 CYP1B1 ...    42   0.007
AC009229-2|AAY15039.1|  543|Homo sapiens unknown protein.              42   0.007
BC096259-1|AAH96259.1|  443|Homo sapiens CYP2C18 protein protein.      40   0.016
L16883-1|AAD13467.1|  169|Homo sapiens cytochrome P-450 2C protein.    40   0.028
AF280111-1|AAG33012.1|  250|Homo sapiens cytochrome P450 subfami...    38   0.065
AK000366-1|BAA91114.1|  408|Homo sapiens protein ( Homo sapiens ...    37   0.20 
AY871801-1|AAX62803.1|  483|Homo sapiens cytochrome P450 family ...    36   0.26 
DQ016495-1|AAY34975.1|  195|Homo sapiens cytochrome P450 1B1 pro...    35   0.80 
X58904-1|CAA41707.1|  371|Homo sapiens steroid 21-monooxygenase ...    34   1.4  
X58902-1|CAA41706.1|  372|Homo sapiens steroid 21-monooxygenase ...    34   1.4  
X58900-1|CAA41704.1|  372|Homo sapiens steroid 21-monooxygenase ...    34   1.4  
X58899-1|CAA41703.1|  368|Homo sapiens steroid 21-monooxygenase ...    34   1.4  
X58898-1|CAA41702.1|  371|Homo sapiens steroid 21-monooxygenase ...    34   1.4  
M17398-1|AAA35740.1|  393|Homo sapiens protein ( Human cytochrom...    33   1.8  
AK131281-1|BAD18456.1|  692|Homo sapiens protein ( Homo sapiens ...    31   9.8  
AB107355-1|BAC67660.1|  738|Homo sapiens KIAA2033 protein protein.     31   9.8  

>AL138805-3|CAB91829.1|  514|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 514

 Score =  182 bits (443), Expect = 3e-45
 Identities = 127/457 (27%), Positives = 213/457 (46%), Gaps = 17/457 (3%)

Query: 40  GDNLMNFEDIPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREK-PIVN 98
           G    N   +PGP S+P++G+L   L ++     +      +   ++YG + R K     
Sbjct: 49  GGETQNAAALPGPTSWPLLGSL---LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFE 105

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
            VH+  P  +EA++R +  YP R        YR  +   Y   GLL   G DW R+RS F
Sbjct: 106 SVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGY---GLLILEGEDWQRVRSAF 162

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKNDFLTFLNRLNLEIIGVVAFNE 216
           QK    P  V    +  + +  +F+  I    D+     D  + LN+ + E I +V + +
Sbjct: 163 QKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEK 222

Query: 217 RFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKI 276
           RF     +  D        I     S  G M +    L K  +T +++   +  +  + I
Sbjct: 223 RFGLLQKNAGDEAVNFIMAIKTMM-STFGRMMVTPVELHKSLNTKVWQ---DHTLAWDTI 278

Query: 277 STDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
              +     N  E    +     L     Q +L  K++   + ++ +AA++TTA +  ++
Sbjct: 279 FKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWI 338

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LY+++RN + Q ++ +E+ ++LP+       D L    Y+++ +KES+RL P      R 
Sbjct: 339 LYNLSRNPQVQQKLLKEIQSVLPENQVPRAED-LRNMPYLKACLKESMRLTPSVPFTTRT 397

Query: 397 LQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLP 456
           L K  VL  Y++PKGTV++              D   F+PERW++   + E I+PF  LP
Sbjct: 398 LDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ---EKEKINPFAHLP 454

Query: 457 FGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
           FG G R CI RRLAE  + + L  ++R+++IQ    E
Sbjct: 455 FGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE 491


>L13286-1|AAA62379.1|  513|Homo sapiens 1,25-dihydroxyvitamin D3
           24-hydroxylase protein.
          Length = 513

 Score =  171 bits (417), Expect = 4e-42
 Identities = 125/457 (27%), Positives = 210/457 (45%), Gaps = 18/457 (3%)

Query: 40  GDNLMNFEDIPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREK-PIVN 98
           G    N   +PGP S+P++ +L   L ++     +      +   ++YG + R K     
Sbjct: 49  GGETQNAAALPGPTSWPLLASL---LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFE 105

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
            VH+  P  +EA++R +   P R        YR  +   Y   GLL   G DW R+RS F
Sbjct: 106 SVHLGSPCLLEALYRTES-VPQRLEIKPWKAYRDYRKEGY---GLLILEGEDWQRVRSAF 161

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKNDFLTFLNRLNLEIIGVVAFNE 216
           QK    P  V    +  + +  +F+  I    D+     D  + LN+ + E I +V + +
Sbjct: 162 QKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEK 221

Query: 217 RFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKI 276
           RF     +  D        I     S  G M +    L K  +T +++      +  + I
Sbjct: 222 RFGLLQKNAGDEAVNFIMAIKTMM-STFGRMMVTPVELHKSLNTKVWQ---GHTLAWDTI 277

Query: 277 STDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
              +     N  E    +     L     Q +L  K++   + ++ +AA++TTA +  ++
Sbjct: 278 FKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWI 337

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LY+++RN + Q ++ +E+ ++LP+       D L    Y+++ +KES+RL P      R 
Sbjct: 338 LYNLSRNPQVQQKLLKEIQSVLPENQRPREED-LRNMPYLKACLKESMRLTPGVPFTTRT 396

Query: 397 LQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLP 456
           L K  VL  Y++PKGTV++              D   F+PERW++   + E I+PF  LP
Sbjct: 397 LDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ---EKEKINPFAHLP 453

Query: 457 FGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
           FG G R CI RRLAE  + + L  ++R+++IQ    E
Sbjct: 454 FGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE 490


>M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase
           protein.
          Length = 531

 Score =  158 bits (383), Expect = 5e-38
 Identities = 112/423 (26%), Positives = 198/423 (46%), Gaps = 22/423 (5%)

Query: 108 IEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQS 167
           +E V RQ+ +YP R     M  ++ ++     T G   T G  W++LR    +    P  
Sbjct: 114 LEQVMRQEGKYPVRND---MELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAE 170

Query: 168 VKTHVSDTDNIAKEFV---EWIKRDKVSSK--NDFLTFLNRLNLEIIGVVAFNERFNSFA 222
              +    + +  +F+   + ++ +  S    +D         LE I  + F +R     
Sbjct: 171 AALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQ 230

Query: 223 LSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILI 282
            S  +      ++I   F ++     L K   W     P +K+ ++    +      ++ 
Sbjct: 231 RSIPEDTVTFVRSIGLMFQNSLYATFLPK---WTRPVLPFWKRYLDGWNAIFSFGKKLID 287

Query: 283 RKINLFESD------DSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
            K+   E+       D       L   L   QL  ++ MG + ++LMA +DTT+ T ++ 
Sbjct: 288 EKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWA 347

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LYH++++   Q+ + EE+  ++P        D  +    +++ +KE+LRL PV     R 
Sbjct: 348 LYHLSKDPEIQEALHEEVVGVVPAGQVPQHKD-FAHMPLLKAVLKETLRLYPVVPTNSRI 406

Query: 397 LQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS-PQYETI-HPFLS 454
           ++K+I + G+  PK T  V  +   SR P    +P +F+P RW+R S P    I HPF S
Sbjct: 407 IEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGS 466

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE--ELGVKTLLINKPNKPVSLNF 512
           +PFG+G R+C+ RR+AE  + ++L RLI+++++  A E  EL     ++  PNK V L F
Sbjct: 467 VPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQF 526

Query: 513 IPR 515
           + R
Sbjct: 527 LQR 529


>BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family
           27, subfamily A, polypeptide 1 protein.
          Length = 531

 Score =  158 bits (383), Expect = 5e-38
 Identities = 112/423 (26%), Positives = 198/423 (46%), Gaps = 22/423 (5%)

Query: 108 IEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQS 167
           +E V RQ+ +YP R     M  ++ ++     T G   T G  W++LR    +    P  
Sbjct: 114 LEQVMRQEGKYPVRND---MELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAE 170

Query: 168 VKTHVSDTDNIAKEFV---EWIKRDKVSSK--NDFLTFLNRLNLEIIGVVAFNERFNSFA 222
              +    + +  +F+   + ++ +  S    +D         LE I  + F +R     
Sbjct: 171 AALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQ 230

Query: 223 LSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILI 282
            S  +      ++I   F ++     L K   W     P +K+ ++    +      ++ 
Sbjct: 231 RSIPEDTVTFVRSIGLMFQNSLYATFLPK---WTRPVLPFWKRYLDGWNAIFSFGKKLID 287

Query: 283 RKINLFESD------DSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
            K+   E+       D       L   L   QL  ++ MG + ++LMA +DTT+ T ++ 
Sbjct: 288 EKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWA 347

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LYH++++   Q+ + EE+  ++P        D  +    +++ +KE+LRL PV     R 
Sbjct: 348 LYHLSKDPEIQEALHEEVVGVVPAGQVPQHKD-FAHMPLLKAVLKETLRLYPVVPTNSRI 406

Query: 397 LQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS-PQYETI-HPFLS 454
           ++K+I + G+  PK T  V  +   SR P    +P +F+P RW+R S P    I HPF S
Sbjct: 407 IEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGS 466

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE--ELGVKTLLINKPNKPVSLNF 512
           +PFG+G R+C+ RR+AE  + ++L RLI+++++  A E  EL     ++  PNK V L F
Sbjct: 467 VPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQF 526

Query: 513 IPR 515
           + R
Sbjct: 527 LQR 529


>BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family
           27, subfamily A, polypeptide 1 protein.
          Length = 531

 Score =  158 bits (383), Expect = 5e-38
 Identities = 112/423 (26%), Positives = 198/423 (46%), Gaps = 22/423 (5%)

Query: 108 IEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQS 167
           +E V RQ+ +YP R     M  ++ ++     T G   T G  W++LR    +    P  
Sbjct: 114 LEQVMRQEGKYPVRND---MELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAE 170

Query: 168 VKTHVSDTDNIAKEFV---EWIKRDKVSSK--NDFLTFLNRLNLEIIGVVAFNERFNSFA 222
              +    + +  +F+   + ++ +  S    +D         LE I  + F +R     
Sbjct: 171 AALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQ 230

Query: 223 LSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILI 282
            S  +      ++I   F ++     L K   W     P +K+ ++    +      ++ 
Sbjct: 231 RSIPEDTVTFVRSIGLMFQNSLYATFLPK---WTRPVLPFWKRYLDGWNAIFSFGKKLID 287

Query: 283 RKINLFESD------DSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
            K+   E+       D       L   L   QL  ++ MG + ++LMA +DTT+ T ++ 
Sbjct: 288 EKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWA 347

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LYH++++   Q+ + EE+  ++P        D  +    +++ +KE+LRL PV     R 
Sbjct: 348 LYHLSKDPEIQEALHEEVVGVVPAGQVPQHKD-FAHMPLLKAVLKETLRLYPVVPTNSRI 406

Query: 397 LQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS-PQYETI-HPFLS 454
           ++K+I + G+  PK T  V  +   SR P    +P +F+P RW+R S P    I HPF S
Sbjct: 407 IEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGS 466

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE--ELGVKTLLINKPNKPVSLNF 512
           +PFG+G R+C+ RR+AE  + ++L RLI+++++  A E  EL     ++  PNK V L F
Sbjct: 467 VPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQF 526

Query: 513 IPR 515
           + R
Sbjct: 527 LQR 529


>X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase
           protein.
          Length = 530

 Score =  157 bits (380), Expect = 1e-37
 Identities = 112/423 (26%), Positives = 198/423 (46%), Gaps = 22/423 (5%)

Query: 108 IEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQS 167
           +E V RQ+ +YP R     M  ++ ++     T G   T G  W++LR    +    P  
Sbjct: 113 LEQVMRQEGKYPVRND---MELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAE 169

Query: 168 VKTHVSDTDNIAKEFV---EWIKRDKVSSK--NDFLTFLNRLNLEIIGVVAFNERFNSFA 222
              +    + +  +F+   + ++ +  S    +D         LE I  + F +R     
Sbjct: 170 RALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQ 229

Query: 223 LSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILI 282
            S  +      ++I   F ++     L K   W     P +K+ ++    +      ++ 
Sbjct: 230 RSIPEDTVTFVRSIGLMFQNSLYATFLPK---WTRPVLPFWKRYLDGWNAIFSFGKKLID 286

Query: 283 RKINLFESD------DSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
            K+   E+       D       L   L   QL  ++ MG + ++LMA +DTT+ T ++ 
Sbjct: 287 EKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWA 346

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LYH++++   Q+ + EE+  ++P        D  +    +++ +KE+LRL PV     R 
Sbjct: 347 LYHLSKDPEIQEALHEEVVGVVPAGQVPQHKD-FAHMPLLKAVLKETLRLYPVVPTNSRI 405

Query: 397 LQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS-PQYETI-HPFLS 454
           ++K+I + G+  PK T  V  +   SR P    +P +F+P RW+R S P    I HPF S
Sbjct: 406 IEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGS 465

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE--ELGVKTLLINKPNKPVSLNF 512
           +PFG+G R+C+ RR+AE  + ++L RLI+++++  A E  EL     ++  PNK V L F
Sbjct: 466 VPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQF 525

Query: 513 IPR 515
           + R
Sbjct: 526 LQR 528


>AY178622-1|AAO21126.1|  531|Homo sapiens steroid hydroxylase
           protein.
          Length = 531

 Score =  156 bits (379), Expect = 2e-37
 Identities = 112/423 (26%), Positives = 197/423 (46%), Gaps = 22/423 (5%)

Query: 108 IEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQS 167
           +E V RQ+ +YP R     M  ++ ++     T G   T G  W++LR    +    P  
Sbjct: 114 LEQVMRQEGKYPVRND---MELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAE 170

Query: 168 VKTHVSDTDNIAKEFV---EWIKRDKVSSK--NDFLTFLNRLNLEIIGVVAFNERFNSFA 222
              +    + +  +F+   + ++ +  S    +D         LE I  + F +R     
Sbjct: 171 AALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQ 230

Query: 223 LSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILI 282
            S  +      ++I   F ++     L K   W     P +K+ ++    +      ++ 
Sbjct: 231 RSIPEDTVTFVRSIGLMFQNSLYATFLPK---WTRPVLPFWKRYLDGWNAIFSFGKKLID 287

Query: 283 RKINLFESD------DSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
            K+   E+       D       L   L   QL  ++ MG + ++LMA +DTT+ T ++ 
Sbjct: 288 EKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWA 347

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LYH++++   Q  + EE+  ++P        D  +    +++ +KE+LRL PV     R 
Sbjct: 348 LYHLSKDPEIQKALHEEVVGVVPAGQVPQHKD-FAHMPLLKAVLKETLRLYPVVPTNSRI 406

Query: 397 LQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS-PQYETI-HPFLS 454
           ++K+I + G+  PK T  V  +   SR P    +P +F+P RW+R S P    I HPF S
Sbjct: 407 IEKEIEVDGFLFPKNTQFVFCHYEVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGS 466

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE--ELGVKTLLINKPNKPVSLNF 512
           +PFG+G R+C+ RR+AE  + ++L RLI+++++  A E  EL     ++  PNK V L F
Sbjct: 467 VPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQF 526

Query: 513 IPR 515
           + R
Sbjct: 527 LQR 529


>X05367-1|CAA28965.1|  521|Homo sapiens desmolase protein.
          Length = 521

 Score =  155 bits (377), Expect = 3e-37
 Identities = 123/445 (27%), Positives = 206/445 (46%), Gaps = 21/445 (4%)

Query: 81  ILNWRRYGSLVREK-PIVNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYN 139
           + N+++YG + REK   V  V+V DP+D+  +F+ +   P R        Y         
Sbjct: 79  VQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI- 137

Query: 140 TGGLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKN-- 195
             G+L      W + R    +   +P++ K  +   D ++++FV  + R   K  S N  
Sbjct: 138 --GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYS 195

Query: 196 -DFLTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL 254
            D    L R   E I  V F ER             R    I   F ++  ++ L    L
Sbjct: 196 GDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPD-L 254

Query: 255 WKMFSTPLYKKLVNS-QIYLEKISTDILIRKI--NLFESDDSKND-KSLLKTFLQQPQLD 310
           +++F T  +K  V +  + L K   DI  +     L +     +D + +L   L   ++ 
Sbjct: 255 FRLFRTKTWKDHVAAWDVILSK--ADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMS 312

Query: 311 HKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVL 370
            +DI   + ++L   +DTT+ T  + LY +ARN + QD +  E+     +   ++ A +L
Sbjct: 313 FEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDM-ATML 371

Query: 371 SKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD 430
                +++SIKE+LRL+P+S+ + R+L  D+VL+ Y IP  T++        R P F  D
Sbjct: 372 QLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFD 431

Query: 431 PLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWA 490
           P  F P RW+    + + I  F +L FG G R C+ RR+AE  + I L+ ++  F ++  
Sbjct: 432 PENFDPTRWL---SKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ 488

Query: 491 G-EELGVKTLLINKPNKPVSLNFIP 514
              ++G    LI  P KP+S  F P
Sbjct: 489 HLSDVGTTFNLILMPEKPISFTFWP 513


>M14565-1|AAA52162.1|  521|Homo sapiens CYP11A protein.
          Length = 521

 Score =  154 bits (373), Expect = 8e-37
 Identities = 122/445 (27%), Positives = 205/445 (46%), Gaps = 21/445 (4%)

Query: 81  ILNWRRYGSLVREK-PIVNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYN 139
           + N+++YG + REK   V  V+V DP+D+  +F+ +   P R        Y         
Sbjct: 79  VQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI- 137

Query: 140 TGGLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKN-- 195
             G+L      W + R    +   +P++ K  +   D ++++FV  + R   K  S N  
Sbjct: 138 --GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYS 195

Query: 196 -DFLTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL 254
            D    L R   E I  V F ER             R    I   F ++  ++ L    L
Sbjct: 196 GDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPD-L 254

Query: 255 WKMFSTPLYKKLVNS-QIYLEKISTDILIRKI--NLFESDDSKND-KSLLKTFLQQPQLD 310
           +++F T  +K  V +  +   K   DI  +     L +     +D + +L   L   ++ 
Sbjct: 255 FRLFRTKTWKDHVAAWDVIFSK--ADIYTQNFYWELRQKGSVHHDYRGMLYRLLGDSKMS 312

Query: 311 HKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVL 370
            +DI   + ++L   +DTT+ T  + LY +ARN + QD +  E+     +   ++ A +L
Sbjct: 313 FEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDM-ATML 371

Query: 371 SKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD 430
                +++SIKE+LRL+P+S+ + R+L  D+VL+ Y IP  T++        R P F  D
Sbjct: 372 QLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFD 431

Query: 431 PLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWA 490
           P  F P RW+    + + I  F +L FG G R C+ RR+AE  + I L+ ++  F ++  
Sbjct: 432 PENFDPTRWL---SKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ 488

Query: 491 G-EELGVKTLLINKPNKPVSLNFIP 514
              ++G    LI  P KP+S  F P
Sbjct: 489 HLSDVGTTFNLILMPEKPISFTFWP 513


>BC032329-1|AAH32329.1|  521|Homo sapiens cytochrome P450, family
           11, subfamily A, polypeptide 1 protein.
          Length = 521

 Score =  154 bits (373), Expect = 8e-37
 Identities = 122/445 (27%), Positives = 205/445 (46%), Gaps = 21/445 (4%)

Query: 81  ILNWRRYGSLVREK-PIVNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYN 139
           + N+++YG + REK   V  V+V DP+D+  +F+ +   P R        Y         
Sbjct: 79  VQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI- 137

Query: 140 TGGLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKN-- 195
             G+L      W + R    +   +P++ K  +   D ++++FV  + R   K  S N  
Sbjct: 138 --GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYS 195

Query: 196 -DFLTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL 254
            D    L R   E I  V F ER             R    I   F ++  ++ L    L
Sbjct: 196 GDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPD-L 254

Query: 255 WKMFSTPLYKKLVNS-QIYLEKISTDILIRKI--NLFESDDSKND-KSLLKTFLQQPQLD 310
           +++F T  +K  V +  +   K   DI  +     L +     +D + +L   L   ++ 
Sbjct: 255 FRLFRTKTWKDHVAAWDVIFSK--ADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMS 312

Query: 311 HKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVL 370
            +DI   + ++L   +DTT+ T  + LY +ARN + QD +  E+     +   ++ A +L
Sbjct: 313 FEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDM-ATML 371

Query: 371 SKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD 430
                +++SIKE+LRL+P+S+ + R+L  D+VL+ Y IP  T++        R P F  D
Sbjct: 372 QLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFD 431

Query: 431 PLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWA 490
           P  F P RW+    + + I  F +L FG G R C+ RR+AE  + I L+ ++  F ++  
Sbjct: 432 PENFDPTRWL---SKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ 488

Query: 491 G-EELGVKTLLINKPNKPVSLNFIP 514
              ++G    LI  P KP+S  F P
Sbjct: 489 HLSDVGTTFNLILMPEKPISFTFWP 513


>AY288916-1|AAP31972.1|  508|Homo sapiens cytochrome P450, family
           27, subfamily B, polypeptide 1 protein.
          Length = 508

 Score =  153 bits (372), Expect = 1e-36
 Identities = 117/434 (26%), Positives = 191/434 (44%), Gaps = 23/434 (5%)

Query: 97  VNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRS 156
           V  V+V  P  +E + RQ+   P R S +    +R  +       GLL   G +W RLRS
Sbjct: 83  VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRAC---GLLTAEGEEWQRLRS 139

Query: 157 IFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKN------DFLTFLNRLNLEIIG 210
           +       PQ+   +    +N+  + V  ++R +           D      +  LE I 
Sbjct: 140 LLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIA 199

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL------WKMFSTPLYK 264
            V    R                + + + F S    M +           W        +
Sbjct: 200 AVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQ 259

Query: 265 KLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMA 324
               +Q ++E+   +  +R     E D      + L  FL + +L  + I+G + ++L+A
Sbjct: 260 MFAFAQRHVERREAEAAMRNGGQPEKDLESG--AHLTHFLFREELPAQSILGNVTELLLA 317

Query: 325 AIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLL-PKKDDEITADVLSKASYVRSSIKES 383
            +DT + T S+ LY ++R+   Q  +  E+   L P      +A VLS+   +++ +KE 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 384 LRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS 443
           LRL PV  G  R   KDI +  Y IPK T++   +  +SR P    +P +F+P RW+   
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 444 PQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ--WAGEELGVKTLLI 501
           P   T HPF SLPFG G RSC+ RRLAE  + + L +++  FE+Q       +  KT  +
Sbjct: 438 P---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494

Query: 502 NKPNKPVSLNFIPR 515
             P + ++L F+ R
Sbjct: 495 LVPERSINLQFLDR 508


>AF256213-1|AAG00416.1|  508|Homo sapiens 25- hydroxyvitamin
           D-1-alpha-hydroxylase protein.
          Length = 508

 Score =  153 bits (372), Expect = 1e-36
 Identities = 117/434 (26%), Positives = 191/434 (44%), Gaps = 23/434 (5%)

Query: 97  VNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRS 156
           V  V+V  P  +E + RQ+   P R S +    +R  +       GLL   G +W RLRS
Sbjct: 83  VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRAC---GLLTAEGEEWQRLRS 139

Query: 157 IFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKN------DFLTFLNRLNLEIIG 210
           +       PQ+   +    +N+  + V  ++R +           D      +  LE I 
Sbjct: 140 LLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIA 199

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL------WKMFSTPLYK 264
            V    R                + + + F S    M +           W        +
Sbjct: 200 AVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQ 259

Query: 265 KLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMA 324
               +Q ++E+   +  +R     E D      + L  FL + +L  + I+G + ++L+A
Sbjct: 260 MFAFAQRHVERREAEAAMRNGGQPEKDLESG--AHLTHFLFREELPAQSILGNVTELLLA 317

Query: 325 AIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLL-PKKDDEITADVLSKASYVRSSIKES 383
            +DT + T S+ LY ++R+   Q  +  E+   L P      +A VLS+   +++ +KE 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 384 LRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS 443
           LRL PV  G  R   KDI +  Y IPK T++   +  +SR P    +P +F+P RW+   
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 444 PQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ--WAGEELGVKTLLI 501
           P   T HPF SLPFG G RSC+ RRLAE  + + L +++  FE+Q       +  KT  +
Sbjct: 438 P---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494

Query: 502 NKPNKPVSLNFIPR 515
             P + ++L F+ R
Sbjct: 495 LVPERSINLQFLDR 508


>AF246895-1|AAF64299.1|  508|Homo sapiens 25-hydroxyvitamin
           D-1-alpha-hydroxylase protein.
          Length = 508

 Score =  153 bits (372), Expect = 1e-36
 Identities = 117/434 (26%), Positives = 191/434 (44%), Gaps = 23/434 (5%)

Query: 97  VNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRS 156
           V  V+V  P  +E + RQ+   P R S +    +R  +       GLL   G +W RLRS
Sbjct: 83  VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRAC---GLLTAEGEEWQRLRS 139

Query: 157 IFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKN------DFLTFLNRLNLEIIG 210
           +       PQ+   +    +N+  + V  ++R +           D      +  LE I 
Sbjct: 140 LLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIA 199

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL------WKMFSTPLYK 264
            V    R                + + + F S    M +           W        +
Sbjct: 200 AVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQ 259

Query: 265 KLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMA 324
               +Q ++E+   +  +R     E D      + L  FL + +L  + I+G + ++L+A
Sbjct: 260 MFAFAQRHVERREAEAAMRNGGQPEKDLESG--AHLTHFLFREELPAQSILGNVTELLLA 317

Query: 325 AIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLL-PKKDDEITADVLSKASYVRSSIKES 383
            +DT + T S+ LY ++R+   Q  +  E+   L P      +A VLS+   +++ +KE 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 384 LRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS 443
           LRL PV  G  R   KDI +  Y IPK T++   +  +SR P    +P +F+P RW+   
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 444 PQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ--WAGEELGVKTLLI 501
           P   T HPF SLPFG G RSC+ RRLAE  + + L +++  FE+Q       +  KT  +
Sbjct: 438 P---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494

Query: 502 NKPNKPVSLNFIPR 515
             P + ++L F+ R
Sbjct: 495 LVPERSINLQFLDR 508


>AF027152-1|AAC51854.1|  508|Homo sapiens P450 25-hydroxyvitamin D-1
           alpha hydroxylase protein.
          Length = 508

 Score =  153 bits (372), Expect = 1e-36
 Identities = 117/434 (26%), Positives = 191/434 (44%), Gaps = 23/434 (5%)

Query: 97  VNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRS 156
           V  V+V  P  +E + RQ+   P R S +    +R  +       GLL   G +W RLRS
Sbjct: 83  VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRAC---GLLTAEGEEWQRLRS 139

Query: 157 IFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKN------DFLTFLNRLNLEIIG 210
           +       PQ+   +    +N+  + V  ++R +           D      +  LE I 
Sbjct: 140 LLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIA 199

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL------WKMFSTPLYK 264
            V    R                + + + F S    M +           W        +
Sbjct: 200 AVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQ 259

Query: 265 KLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMA 324
               +Q ++E+   +  +R     E D      + L  FL + +L  + I+G + ++L+A
Sbjct: 260 MFAFAQRHVERREAEAAMRNGGQPEKDLESG--AHLTHFLFREELPAQSILGNVTELLLA 317

Query: 325 AIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLL-PKKDDEITADVLSKASYVRSSIKES 383
            +DT + T S+ LY ++R+   Q  +  E+   L P      +A VLS+   +++ +KE 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 384 LRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS 443
           LRL PV  G  R   KDI +  Y IPK T++   +  +SR P    +P +F+P RW+   
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 444 PQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ--WAGEELGVKTLLI 501
           P   T HPF SLPFG G RSC+ RRLAE  + + L +++  FE+Q       +  KT  +
Sbjct: 438 P---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494

Query: 502 NKPNKPVSLNFIPR 515
             P + ++L F+ R
Sbjct: 495 LVPERSINLQFLDR 508


>AF020192-1|AAC51853.1|  508|Homo sapiens 25-hydroxyvitamin
           D-1-alpha-hydroxylase protein.
          Length = 508

 Score =  153 bits (372), Expect = 1e-36
 Identities = 117/434 (26%), Positives = 191/434 (44%), Gaps = 23/434 (5%)

Query: 97  VNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRS 156
           V  V+V  P  +E + RQ+   P R S +    +R  +       GLL   G +W RLRS
Sbjct: 83  VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRAC---GLLTAEGEEWQRLRS 139

Query: 157 IFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKN------DFLTFLNRLNLEIIG 210
           +       PQ+   +    +N+  + V  ++R +           D      +  LE I 
Sbjct: 140 LLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIA 199

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL------WKMFSTPLYK 264
            V    R                + + + F S    M +           W        +
Sbjct: 200 AVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQ 259

Query: 265 KLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMA 324
               +Q ++E+   +  +R     E D      + L  FL + +L  + I+G + ++L+A
Sbjct: 260 MFAFAQRHVERREAEAAMRNGGQPEKDLESG--AHLTHFLFREELPAQSILGNVTELLLA 317

Query: 325 AIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLL-PKKDDEITADVLSKASYVRSSIKES 383
            +DT + T S+ LY ++R+   Q  +  E+   L P      +A VLS+   +++ +KE 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 384 LRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS 443
           LRL PV  G  R   KDI +  Y IPK T++   +  +SR P    +P +F+P RW+   
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 444 PQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ--WAGEELGVKTLLI 501
           P   T HPF SLPFG G RSC+ RRLAE  + + L +++  FE+Q       +  KT  +
Sbjct: 438 P---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494

Query: 502 NKPNKPVSLNFIPR 515
             P + ++L F+ R
Sbjct: 495 LVPERSINLQFLDR 508


>AB006987-1|BAA23418.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1-alpha-hydroxylase protein.
          Length = 508

 Score =  153 bits (372), Expect = 1e-36
 Identities = 117/434 (26%), Positives = 191/434 (44%), Gaps = 23/434 (5%)

Query: 97  VNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRS 156
           V  V+V  P  +E + RQ+   P R S +    +R  +       GLL   G +W RLRS
Sbjct: 83  VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRAC---GLLTAEGEEWQRLRS 139

Query: 157 IFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKN------DFLTFLNRLNLEIIG 210
           +       PQ+   +    +N+  + V  ++R +           D      +  LE I 
Sbjct: 140 LLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIA 199

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL------WKMFSTPLYK 264
            V    R                + + + F S    M +           W        +
Sbjct: 200 AVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQ 259

Query: 265 KLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMA 324
               +Q ++E+   +  +R     E D      + L  FL + +L  + I+G + ++L+A
Sbjct: 260 MFAFAQRHVERREAEAAMRNGGQPEKDLESG--AHLTHFLFREELPAQSILGNVTELLLA 317

Query: 325 AIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLL-PKKDDEITADVLSKASYVRSSIKES 383
            +DT + T S+ LY ++R+   Q  +  E+   L P      +A VLS+   +++ +KE 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 384 LRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS 443
           LRL PV  G  R   KDI +  Y IPK T++   +  +SR P    +P +F+P RW+   
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 444 PQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ--WAGEELGVKTLLI 501
           P   T HPF SLPFG G RSC+ RRLAE  + + L +++  FE+Q       +  KT  +
Sbjct: 438 P---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494

Query: 502 NKPNKPVSLNFIPR 515
             P + ++L F+ R
Sbjct: 495 LVPERSINLQFLDR 508


>AB005990-1|BAA22657.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1alpha-hydroxylase protein.
          Length = 508

 Score =  153 bits (372), Expect = 1e-36
 Identities = 117/434 (26%), Positives = 191/434 (44%), Gaps = 23/434 (5%)

Query: 97  VNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRS 156
           V  V+V  P  +E + RQ+   P R S +    +R  +       GLL   G +W RLRS
Sbjct: 83  VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRAC---GLLTAEGEEWQRLRS 139

Query: 157 IFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKN------DFLTFLNRLNLEIIG 210
           +       PQ+   +    +N+  + V  ++R +           D      +  LE I 
Sbjct: 140 LLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIA 199

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL------WKMFSTPLYK 264
            V    R                + + + F S    M +           W        +
Sbjct: 200 AVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQ 259

Query: 265 KLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMA 324
               +Q ++E+   +  +R     E D      + L  FL + +L  + I+G + ++L+A
Sbjct: 260 MFAFAQRHVERREAEAAMRNGGQPEKDLESG--AHLTHFLFREELPAQSILGNVTELLLA 317

Query: 325 AIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLL-PKKDDEITADVLSKASYVRSSIKES 383
            +DT + T S+ LY ++R+   Q  +  E+   L P      +A VLS+   +++ +KE 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 384 LRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS 443
           LRL PV  G  R   KDI +  Y IPK T++   +  +SR P    +P +F+P RW+   
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 444 PQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ--WAGEELGVKTLLI 501
           P   T HPF SLPFG G RSC+ RRLAE  + + L +++  FE+Q       +  KT  +
Sbjct: 438 P---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494

Query: 502 NKPNKPVSLNFIPR 515
             P + ++L F+ R
Sbjct: 495 LVPERSINLQFLDR 508


>AB005989-1|BAA22656.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1alpha-hydroxylase protein.
          Length = 508

 Score =  153 bits (372), Expect = 1e-36
 Identities = 117/434 (26%), Positives = 191/434 (44%), Gaps = 23/434 (5%)

Query: 97  VNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRS 156
           V  V+V  P  +E + RQ+   P R S +    +R  +       GLL   G +W RLRS
Sbjct: 83  VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRAC---GLLTAEGEEWQRLRS 139

Query: 157 IFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKN------DFLTFLNRLNLEIIG 210
           +       PQ+   +    +N+  + V  ++R +           D      +  LE I 
Sbjct: 140 LLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIA 199

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL------WKMFSTPLYK 264
            V    R                + + + F S    M +           W        +
Sbjct: 200 AVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQ 259

Query: 265 KLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMA 324
               +Q ++E+   +  +R     E D      + L  FL + +L  + I+G + ++L+A
Sbjct: 260 MFAFAQRHVERREAEAAMRNGGQPEKDLESG--AHLTHFLFREELPAQSILGNVTELLLA 317

Query: 325 AIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLL-PKKDDEITADVLSKASYVRSSIKES 383
            +DT + T S+ LY ++R+   Q  +  E+   L P      +A VLS+   +++ +KE 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 384 LRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS 443
           LRL PV  G  R   KDI +  Y IPK T++   +  +SR P    +P +F+P RW+   
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 444 PQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ--WAGEELGVKTLLI 501
           P   T HPF SLPFG G RSC+ RRLAE  + + L +++  FE+Q       +  KT  +
Sbjct: 438 P---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494

Query: 502 NKPNKPVSLNFIPR 515
             P + ++L F+ R
Sbjct: 495 LVPERSINLQFLDR 508


>AB005038-1|BAA23416.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1-alpha-hydroxylase protein.
          Length = 508

 Score =  153 bits (372), Expect = 1e-36
 Identities = 117/434 (26%), Positives = 191/434 (44%), Gaps = 23/434 (5%)

Query: 97  VNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRS 156
           V  V+V  P  +E + RQ+   P R S +    +R  +       GLL   G +W RLRS
Sbjct: 83  VRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRAC---GLLTAEGEEWQRLRS 139

Query: 157 IFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKN------DFLTFLNRLNLEIIG 210
           +       PQ+   +    +N+  + V  ++R +           D      +  LE I 
Sbjct: 140 LLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIA 199

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFL------WKMFSTPLYK 264
            V    R                + + + F S    M +           W        +
Sbjct: 200 AVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQ 259

Query: 265 KLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMA 324
               +Q ++E+   +  +R     E D      + L  FL + +L  + I+G + ++L+A
Sbjct: 260 MFAFAQRHVERREAEAAMRNGGQPEKDLESG--AHLTHFLFREELPAQSILGNVTELLLA 317

Query: 325 AIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLL-PKKDDEITADVLSKASYVRSSIKES 383
            +DT + T S+ LY ++R+   Q  +  E+   L P      +A VLS+   +++ +KE 
Sbjct: 318 GVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEV 377

Query: 384 LRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGS 443
           LRL PV  G  R   KDI +  Y IPK T++   +  +SR P    +P +F+P RW+   
Sbjct: 378 LRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 444 PQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ--WAGEELGVKTLLI 501
           P   T HPF SLPFG G RSC+ RRLAE  + + L +++  FE+Q       +  KT  +
Sbjct: 438 P---TPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTV 494

Query: 502 NKPNKPVSLNFIPR 515
             P + ++L F+ R
Sbjct: 495 LVPERSINLQFLDR 508


>AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylase
           splice variant protein.
          Length = 372

 Score =  148 bits (358), Expect = 5e-35
 Identities = 98/348 (28%), Positives = 166/348 (47%), Gaps = 10/348 (2%)

Query: 148 GPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKNDFLTFLNRLN 205
           G DW R+RS FQK    P  V    +  + +  +F+  I    D+     D  + LN+ +
Sbjct: 10  GEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWS 69

Query: 206 LEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKK 265
            E I +V + +RF     +  D        I     S  G M +    L K  +T +++ 
Sbjct: 70  FESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM-STFGRMMVTPVELHKSLNTKVWQ- 127

Query: 266 LVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAA 325
             +  +  + I   +     N  E    +     L     Q +L  K++   + ++ +AA
Sbjct: 128 --DHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAA 185

Query: 326 IDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLR 385
           ++TTA +  ++LY+++RN + Q ++ +E+ ++LP+       D L    Y+++ +KES+R
Sbjct: 186 VETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED-LRNMPYLKACLKESMR 244

Query: 386 LNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQ 445
           L P      R L K  VL  Y++PKGTV++              D   F+PERW++   +
Sbjct: 245 LTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ---E 301

Query: 446 YETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
            E I+PF  LPFG G R CI RRLAE  + + L  ++R+++IQ    E
Sbjct: 302 KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE 349


>AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 372

 Score =  148 bits (358), Expect = 5e-35
 Identities = 98/348 (28%), Positives = 166/348 (47%), Gaps = 10/348 (2%)

Query: 148 GPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKNDFLTFLNRLN 205
           G DW R+RS FQK    P  V    +  + +  +F+  I    D+     D  + LN+ +
Sbjct: 10  GEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWS 69

Query: 206 LEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKK 265
            E I +V + +RF     +  D        I     S  G M +    L K  +T +++ 
Sbjct: 70  FESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM-STFGRMMVTPVELHKSLNTKVWQ- 127

Query: 266 LVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAA 325
             +  +  + I   +     N  E    +     L     Q +L  K++   + ++ +AA
Sbjct: 128 --DHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAA 185

Query: 326 IDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLR 385
           ++TTA +  ++LY+++RN + Q ++ +E+ ++LP+       D L    Y+++ +KES+R
Sbjct: 186 VETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED-LRNMPYLKACLKESMR 244

Query: 386 LNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQ 445
           L P      R L K  VL  Y++PKGTV++              D   F+PERW++   +
Sbjct: 245 LTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ---E 301

Query: 446 YETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
            E I+PF  LPFG G R CI RRLAE  + + L  ++R+++IQ    E
Sbjct: 302 KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE 349


>BC039307-1|AAH39307.1|  372|Homo sapiens FLJ16008 protein protein.
          Length = 372

 Score =  138 bits (334), Expect = 4e-32
 Identities = 84/244 (34%), Positives = 138/244 (56%), Gaps = 6/244 (2%)

Query: 275 KISTDILIRKINLFESDDSKNDKSLLKTFLQQPQ-LDHKDIMGMMVDILMAAIDTTAYTT 333
           +I  D  +R I  ++ D  +     L T+L   Q L  ++I   + ++L+A +DTT++T 
Sbjct: 131 QIHVDNKLRDIQ-YQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTL 189

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           S+ +Y +AR+   Q  ++ E+   L ++     ADV  K   VR+ +KE+LRL PV  G 
Sbjct: 190 SWTVYILARHPEVQQTVYREIVKNLGERHVPTAADV-PKVPLVRALLKETLRLFPVLPGN 248

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
           GR  Q+D+V+ GY IPKGT +   +  +S   +       F+PERW+R     + +  F 
Sbjct: 249 GRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLR-KGDLDRVDNFG 307

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEELGV--KTLLINKPNKPVSLN 511
           S+PFGHG RSCI RR+AE  I +++++L++ FEI+ + +   V  KT  +  P  P+ + 
Sbjct: 308 SIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVR 367

Query: 512 FIPR 515
           F+ R
Sbjct: 368 FVNR 371


>AK131190-1|BAD18388.1|  372|Homo sapiens .-.-).  protein.
          Length = 372

 Score =  138 bits (334), Expect = 4e-32
 Identities = 84/244 (34%), Positives = 138/244 (56%), Gaps = 6/244 (2%)

Query: 275 KISTDILIRKINLFESDDSKNDKSLLKTFLQQPQ-LDHKDIMGMMVDILMAAIDTTAYTT 333
           +I  D  +R I  ++ D  +     L T+L   Q L  ++I   + ++L+A +DTT++T 
Sbjct: 131 QIHVDNKLRDIQ-YQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTL 189

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           S+ +Y +AR+   Q  ++ E+   L ++     ADV  K   VR+ +KE+LRL PV  G 
Sbjct: 190 SWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADV-PKVPLVRALLKETLRLFPVLPGN 248

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
           GR  Q+D+V+ GY IPKGT +   +  +S   +       F+PERW+R     + +  F 
Sbjct: 249 GRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLR-KGDLDRVDNFG 307

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEELGV--KTLLINKPNKPVSLN 511
           S+PFGHG RSCI RR+AE  I +++++L++ FEI+ + +   V  KT  +  P  P+ + 
Sbjct: 308 SIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVR 367

Query: 512 FIPR 515
           F+ R
Sbjct: 368 FVNR 371


>J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3
           protein.
          Length = 502

 Score =  130 bits (313), Expect = 2e-29
 Identities = 119/480 (24%), Positives = 215/480 (44%), Gaps = 45/480 (9%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P++G +  Y   +  +D E   K      + +G+   + P++ +    DPD I
Sbjct: 38  IPGPTPLPLLGNVLSYRQGLWKFDTECYKKYG----KMWGTYEGQLPVLAIT---DPDVI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
             V         +  ++     R+  P  +    +      +W R+RS+    FTS + +
Sbjct: 91  RTVL-------VKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K             V  ++R+    K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   S+K     FG    +  L    +   F TP+++ L N  ++  K + + L + +N 
Sbjct: 202 PFVESTKKFLK-FGF---LDPLFLSIILFPFLTPVFEAL-NVSLF-PKDTINFLSKSVNR 255

Query: 288 FESDDSKNDKSLLKTFLQQPQLD---------HK-----DIMGMMVDILMAAIDTTAYTT 333
            +     NDK   +    Q  +D         HK     ++    +  + A  +TT+   
Sbjct: 256 MKKS-RLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVL 314

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           SF LY +A +   Q ++ +E+  +LP K    T D + +  Y+   + E+LRL PV+I +
Sbjct: 315 SFTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRL 373

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +KD+ + G  IPKG+++V         P++  +P  F+PER+   S + ++I P++
Sbjct: 374 ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF---SKKKDSIDPYI 430

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
             PFG GPR+CI  R A  N+ + L+R+++ F  +   E    L + T  + +P KP+ L
Sbjct: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL 490


>BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 protein.
          Length = 502

 Score =  130 bits (313), Expect = 2e-29
 Identities = 119/480 (24%), Positives = 215/480 (44%), Gaps = 45/480 (9%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P++G +  Y   +  +D E   K      + +G+   + P++ +    DPD I
Sbjct: 38  IPGPTPLPLLGNVLSYRQGLWKFDTECYKKYG----KMWGTYEGQLPVLAIT---DPDVI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
             V         +  ++     R+  P  +    +      +W R+RS+    FTS + +
Sbjct: 91  RTVL-------VKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K             V  ++R+    K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   S+K     FG    +  L    +   F TP+++ L N  ++  K + + L + +N 
Sbjct: 202 PFVESTKKFLK-FGF---LDPLFLSIILFPFLTPVFEAL-NVSLF-PKDTINFLSKSVNR 255

Query: 288 FESDDSKNDKSLLKTFLQQPQLD---------HK-----DIMGMMVDILMAAIDTTAYTT 333
            +     NDK   +    Q  +D         HK     ++    +  + A  +TT+   
Sbjct: 256 MKKS-RLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVL 314

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           SF LY +A +   Q ++ +E+  +LP K    T D + +  Y+   + E+LRL PV+I +
Sbjct: 315 SFTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRL 373

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +KD+ + G  IPKG+++V         P++  +P  F+PER+   S + ++I P++
Sbjct: 374 ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF---SKKKDSIDPYI 430

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
             PFG GPR+CI  R A  N+ + L+R+++ F  +   E    L + T  + +P KP+ L
Sbjct: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL 490


>AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.
          Length = 502

 Score =  130 bits (313), Expect = 2e-29
 Identities = 119/480 (24%), Positives = 215/480 (44%), Gaps = 45/480 (9%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P++G +  Y   +  +D E   K      + +G+   + P++ +    DPD I
Sbjct: 38  IPGPTPLPLLGNVLSYRQGLWKFDTECYKKYG----KMWGTYEGQLPVLAIT---DPDVI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
             V         +  ++     R+  P  +    +      +W R+RS+    FTS + +
Sbjct: 91  RTVL-------VKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K             V  ++R+    K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   S+K     FG    +  L    +   F TP+++ L N  ++  K + + L + +N 
Sbjct: 202 PFVESTKKFLK-FGF---LDPLFLSIILFPFLTPVFEAL-NVSLF-PKDTINFLSKSVNR 255

Query: 288 FESDDSKNDKSLLKTFLQQPQLD---------HK-----DIMGMMVDILMAAIDTTAYTT 333
            +     NDK   +    Q  +D         HK     ++    +  + A  +TT+   
Sbjct: 256 MKKS-RLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVL 314

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           SF LY +A +   Q ++ +E+  +LP K    T D + +  Y+   + E+LRL PV+I +
Sbjct: 315 SFTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRL 373

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +KD+ + G  IPKG+++V         P++  +P  F+PER+   S + ++I P++
Sbjct: 374 ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF---SKKKDSIDPYI 430

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
             PFG GPR+CI  R A  N+ + L+R+++ F  +   E    L + T  + +P KP+ L
Sbjct: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL 490


>BC109084-1|AAI09085.1|  448|Homo sapiens CYP24A1 protein protein.
          Length = 448

 Score =  128 bits (309), Expect = 5e-29
 Identities = 98/377 (25%), Positives = 172/377 (45%), Gaps = 14/377 (3%)

Query: 40  GDNLMNFEDIPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREK-PIVN 98
           G    N   +PGP S+P++G+L   L ++     +      +   ++YG + R K     
Sbjct: 49  GGETQNAAALPGPTSWPLLGSL---LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFE 105

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
            VH+  P  +EA++R +  YP R        YR  +   Y   GLL   G DW R+RS F
Sbjct: 106 SVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGY---GLLILEGEDWQRVRSAF 162

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKNDFLTFLNRLNLEIIGVVAFNE 216
           QK    P  V    +  + +  +F+  I    D+     D  + LN+ + E I +V + +
Sbjct: 163 QKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEK 222

Query: 217 RFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKI 276
           RF     +  D        I     S  G M +    L K  +T +++   +  +  + I
Sbjct: 223 RFGLLQKNAGDEAVNFIMAIKTMM-STFGRMMVTPVELHKSLNTKVWQ---DHTLAWDTI 278

Query: 277 STDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
              +     N  E    +     L     Q +L  K++   + ++ +AA++TTA +  ++
Sbjct: 279 FKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWI 338

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LY+++RN + Q ++ +E+ ++LP ++    A+ L    Y+++ +KES+RL P      R 
Sbjct: 339 LYNLSRNPQVQQKLLKEIQSVLP-ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397

Query: 397 LQKDIVLKGYSIPKGTV 413
           L K  VL  Y++PKG V
Sbjct: 398 LDKATVLGEYALPKGIV 414


>BC109083-1|AAI09084.1|  448|Homo sapiens CYP24A1 protein protein.
          Length = 448

 Score =  128 bits (309), Expect = 5e-29
 Identities = 98/377 (25%), Positives = 172/377 (45%), Gaps = 14/377 (3%)

Query: 40  GDNLMNFEDIPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREK-PIVN 98
           G    N   +PGP S+P++G+L   L ++     +      +   ++YG + R K     
Sbjct: 49  GGETQNAAALPGPTSWPLLGSL---LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFE 105

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
            VH+  P  +EA++R +  YP R        YR  +   Y   GLL   G DW R+RS F
Sbjct: 106 SVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGY---GLLILEGEDWQRVRSAF 162

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKNDFLTFLNRLNLEIIGVVAFNE 216
           QK    P  V    +  + +  +F+  I    D+     D  + LN+ + E I +V + +
Sbjct: 163 QKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEK 222

Query: 217 RFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKI 276
           RF     +  D        I     S  G M +    L K  +T +++   +  +  + I
Sbjct: 223 RFGLLQKNAGDEAVNFIMAIKTMM-STFGRMMVTPVELHKSLNTKVWQ---DHTLAWDTI 278

Query: 277 STDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
              +     N  E    +     L     Q +L  K++   + ++ +AA++TTA +  ++
Sbjct: 279 FKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWI 338

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LY+++RN + Q ++ +E+ ++LP ++    A+ L    Y+++ +KES+RL P      R 
Sbjct: 339 LYNLSRNPQVQQKLLKEIQSVLP-ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397

Query: 397 LQKDIVLKGYSIPKGTV 413
           L K  VL  Y++PKG V
Sbjct: 398 LDKATVLGEYALPKGIV 414


>AL138805-2|CAM27343.1|  448|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 448

 Score =  128 bits (309), Expect = 5e-29
 Identities = 98/377 (25%), Positives = 172/377 (45%), Gaps = 14/377 (3%)

Query: 40  GDNLMNFEDIPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREK-PIVN 98
           G    N   +PGP S+P++G+L   L ++     +      +   ++YG + R K     
Sbjct: 49  GGETQNAAALPGPTSWPLLGSL---LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFE 105

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
            VH+  P  +EA++R +  YP R        YR  +   Y   GLL   G DW R+RS F
Sbjct: 106 SVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGY---GLLILEGEDWQRVRSAF 162

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKR--DKVSSKNDFLTFLNRLNLEIIGVVAFNE 216
           QK    P  V    +  + +  +F+  I    D+     D  + LN+ + E I +V + +
Sbjct: 163 QKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEK 222

Query: 217 RFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKI 276
           RF     +  D        I     S  G M +    L K  +T +++   +  +  + I
Sbjct: 223 RFGLLQKNAGDEAVNFIMAIKTMM-STFGRMMVTPVELHKSLNTKVWQ---DHTLAWDTI 278

Query: 277 STDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFV 336
              +     N  E    +     L     Q +L  K++   + ++ +AA++TTA +  ++
Sbjct: 279 FKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWI 338

Query: 337 LYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRW 396
           LY+++RN + Q ++ +E+ ++LP ++    A+ L    Y+++ +KES+RL P      R 
Sbjct: 339 LYNLSRNPQVQQKLLKEIQSVLP-ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397

Query: 397 LQKDIVLKGYSIPKGTV 413
           L K  VL  Y++PKG V
Sbjct: 398 LDKATVLGEYALPKGIV 414


>AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 variant protein.
          Length = 502

 Score =  127 bits (307), Expect = 8e-29
 Identities = 118/480 (24%), Positives = 213/480 (44%), Gaps = 45/480 (9%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P++G +  Y   +  +D E   K      + +G+   + P++ +    DPD I
Sbjct: 38  IPGPTPLPLLGNVLSYRQGLWKFDTECYKKYG----KMWGTYEGQLPVLAIT---DPDVI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
             V         +  ++     R+  P  +    +      +W R+R +    FTS + +
Sbjct: 91  RTVL-------VKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRPLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K             V  ++R+    K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   S+K     FG    +  L    +   F TP+++ L N  ++  K + + L + +N 
Sbjct: 202 PFVESTKKFLK-FGF---LDPLFLSIILFPFLTPVFEAL-NVSLF-PKDTINFLSKSVNR 255

Query: 288 FESDDSKNDKSLLKTFLQQPQLD---------HK-----DIMGMMVDILMAAIDTTAYTT 333
            +     NDK   +    Q  +D         HK     ++    +  + A  +TT+   
Sbjct: 256 MKKS-RLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVL 314

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           SF LY +A +   Q ++ +E+  +LP K    T D + +  Y+   + E+LRL PV+I +
Sbjct: 315 SFTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRL 373

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R   KD+ + G  IPKG+++V         P++  +P  F+PER+   S + ++I P++
Sbjct: 374 ERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF---SKKKDSIDPYI 430

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
             PFG GPR+CI  R A  N+ + L+R+++ F  +   E    L + T  + +P KP+ L
Sbjct: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL 490


>AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43.1
           protein.
          Length = 503

 Score =  126 bits (305), Expect = 1e-28
 Identities = 120/479 (25%), Positives = 216/479 (45%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +GT+  YL  + ++D E  +K   + W  Y     ++P   ++ + DPD I
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM-WGLYEG---QQP---MLVIMDPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    L      +W R+R++    FTS +  
Sbjct: 91  KTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK-F 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKN-DFLTFLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++++  +SK+ +   F     +++I    F    +S   + QD
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P  ++ K +      +  ++ +    L+  F TP+++ L N  ++ + + T  L   I  
Sbjct: 202 PFLKNMKKLLKLDFLDPFLLLIS---LFP-FLTPVFEAL-NIGLFPKDV-THFLKNSIER 255

Query: 288 FESDDSKNDKSLLKTFLQQ--------PQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K+ +     F QQ            HK     +++   + I+ AA DTT+ T  
Sbjct: 256 MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KDI + G  IPKG  ++         P++  +P  F PER+ + +   ++I  +  
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNK--DSIDLYRY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
           +PFG GPR+CI  R A  NI + ++R ++ F  +   E    L +  L I +P KP+ L
Sbjct: 433 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 491


>AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score =  126 bits (305), Expect = 1e-28
 Identities = 120/479 (25%), Positives = 216/479 (45%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +GT+  YL  + ++D E  +K   + W  Y     ++P   ++ + DPD I
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM-WGLYEG---QQP---MLVIMDPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    L      +W R+R++    FTS +  
Sbjct: 91  KTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK-F 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKN-DFLTFLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++++  +SK+ +   F     +++I    F    +S   + QD
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P  ++ K +      +  ++ +    L+  F TP+++ L N  ++ + + T  L   I  
Sbjct: 202 PFLKNMKKLLKLDFLDPFLLLIS---LFP-FLTPVFEAL-NIGLFPKDV-THFLKNSIER 255

Query: 288 FESDDSKNDKSLLKTFLQQ--------PQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K+ +     F QQ            HK     +++   + I+ AA DTT+ T  
Sbjct: 256 MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KDI + G  IPKG  ++         P++  +P  F PER+ + +   ++I  +  
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNK--DSIDLYRY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
           +PFG GPR+CI  R A  NI + ++R ++ F  +   E    L +  L I +P KP+ L
Sbjct: 433 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 491


>AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43
           protein.
          Length = 503

 Score =  126 bits (305), Expect = 1e-28
 Identities = 120/479 (25%), Positives = 216/479 (45%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +GT+  YL  + ++D E  +K   + W  Y     ++P   ++ + DPD I
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM-WGLYEG---QQP---MLVIMDPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    L      +W R+R++    FTS +  
Sbjct: 91  KTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK-F 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKN-DFLTFLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++++  +SK+ +   F     +++I    F    +S   + QD
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P  ++ K +      +  ++ +    L+  F TP+++ L N  ++ + + T  L   I  
Sbjct: 202 PFLKNMKKLLKLDFLDPFLLLIS---LFP-FLTPVFEAL-NIGLFPKDV-THFLKNSIER 255

Query: 288 FESDDSKNDKSLLKTFLQQ--------PQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K+ +     F QQ            HK     +++   + I+ AA DTT+ T  
Sbjct: 256 MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KDI + G  IPKG  ++         P++  +P  F PER+ + +   ++I  +  
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNK--DSIDLYRY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
           +PFG GPR+CI  R A  NI + ++R ++ F  +   E    L +  L I +P KP+ L
Sbjct: 433 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 491


>AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score =  126 bits (305), Expect = 1e-28
 Identities = 120/479 (25%), Positives = 216/479 (45%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +GT+  YL  + ++D E  +K   + W  Y     ++P   ++ + DPD I
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM-WGLYEG---QQP---MLVIMDPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    L      +W R+R++    FTS +  
Sbjct: 91  KTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK-F 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKN-DFLTFLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++++  +SK+ +   F     +++I    F    +S   + QD
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P  ++ K +      +  ++ +    L+  F TP+++ L N  ++ + + T  L   I  
Sbjct: 202 PFLKNMKKLLKLDFLDPFLLLIS---LFP-FLTPVFEAL-NIGLFPKDV-THFLKNSIER 255

Query: 288 FESDDSKNDKSLLKTFLQQ--------PQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K+ +     F QQ            HK     +++   + I+ AA DTT+ T  
Sbjct: 256 MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KDI + G  IPKG  ++         P++  +P  F PER+ + +   ++I  +  
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNK--DSIDLYRY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
           +PFG GPR+CI  R A  NI + ++R ++ F  +   E    L +  L I +P KP+ L
Sbjct: 433 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 491


>AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.
          Length = 503

 Score =  126 bits (305), Expect = 1e-28
 Identities = 120/479 (25%), Positives = 216/479 (45%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +GT+  YL  + ++D E  +K   + W  Y     ++P   ++ + DPD I
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM-WGLYEG---QQP---MLVIMDPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    L      +W R+R++    FTS +  
Sbjct: 91  KTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK-F 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKN-DFLTFLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++++  +SK+ +   F     +++I    F    +S   + QD
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P  ++ K +      +  ++ +    L+  F TP+++ L N  ++ + + T  L   I  
Sbjct: 202 PFLKNMKKLLKLDFLDPFLLLIS---LFP-FLTPVFEAL-NIGLFPKDV-THFLKNSIER 255

Query: 288 FESDDSKNDKSLLKTFLQQ--------PQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K+ +     F QQ            HK     +++   + I+ AA DTT+ T  
Sbjct: 256 MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KDI + G  IPKG  ++         P++  +P  F PER+ + +   ++I  +  
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNK--DSIDLYRY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
           +PFG GPR+CI  R A  NI + ++R ++ F  +   E    L +  L I +P KP+ L
Sbjct: 433 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 491


>S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D
           24-hydroxylase cytochrome P450 subunit protein.
          Length = 257

 Score =  125 bits (302), Expect = 3e-28
 Identities = 67/208 (32%), Positives = 112/208 (53%), Gaps = 4/208 (1%)

Query: 286 NLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKR 345
           N  E    +     L     Q +L  K++   + ++ +AA++TTA +  ++LY+++RN +
Sbjct: 31  NRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 90

Query: 346 CQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKG 405
            Q ++ +E+ ++LP+       D L    Y+++ +KES+RL P      R L K  VL  
Sbjct: 91  VQQKLLKEIQSVLPENQVPRAED-LRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE 149

Query: 406 YSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCI 465
           Y++PKGTV++              D   F+PERW++   + E I+PF  LPFG G R CI
Sbjct: 150 YALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ---EKEKINPFAHLPFGVGKRMCI 206

Query: 466 ARRLAEQNICIILMRLIREFEIQWAGEE 493
            RRLAE  + + L  ++R+++IQ    E
Sbjct: 207 GRRLAELQLHLALCWIVRKYDIQATDNE 234


>M28253-1|AAA36404.1|  239|Homo sapiens cytochrome P-450-scc
           protein.
          Length = 239

 Score =  124 bits (300), Expect = 6e-28
 Identities = 70/219 (31%), Positives = 117/219 (53%), Gaps = 5/219 (2%)

Query: 297 KSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHT 356
           + +L   L   ++  +DI   + ++L   +DTT+ T  + LY +ARN + QD +  E+  
Sbjct: 17  RGMLYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA 76

Query: 357 LLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVT 416
              +   ++ A +L     +++SIKE+LRL+P+S+ + R+L  D+VL+ Y IP  T++  
Sbjct: 77  ARHQAQGDM-ATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQV 135

Query: 417 QNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICI 476
                 R P F  DP  F P RW+    + + I  F +L FG G R C+ RR+AE  + I
Sbjct: 136 AIYALGREPTFFFDPENFDPTRWL---SKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 192

Query: 477 ILMRLIREFEIQWAG-EELGVKTLLINKPNKPVSLNFIP 514
            L+ ++  F ++     ++G    LI  P KP+S  F P
Sbjct: 193 FLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWP 231


>AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43.3
           protein.
          Length = 503

 Score =  123 bits (297), Expect = 1e-27
 Identities = 119/479 (24%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +GT+  YL  + ++D E  +K   + W  Y     ++P   ++ + DPD I
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM-WGLYEG---QQP---MLVIMDPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    L      +W R+R++    FTS +  
Sbjct: 91  KTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK-F 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKN-DFLTFLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++++  +SK+ +   F     +++I    F    +S   + QD
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P  ++ K +      +  ++ +    L+  F TP+++ L N  ++ + + T  L   I  
Sbjct: 202 PFLKNMKKLLKLDFLDPFLLLIS---LFP-FLTPVFEAL-NIGLFPKDV-THFLKNSIER 255

Query: 288 FESDDSKNDKSLLKTFLQQ--------PQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K+ +     F QQ            HK     +++   + I+ AA DTT+ T  
Sbjct: 256 MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +L  K   +T D L +  Y+   + E+LRL PV   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLANK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KDI + G  IPKG  ++         P++  +P  F PER+ + +   ++I  +  
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNK--DSIDLYRY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
           +PFG GPR+CI  R A  NI + ++R ++ F  +   E    L +  L I +P KP+ L
Sbjct: 433 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 491


>AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 504

 Score =  122 bits (295), Expect = 2e-27
 Identities = 119/479 (24%), Positives = 212/479 (44%), Gaps = 41/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +GT+  YL  + ++D E  +K   + W  Y     ++P   ++ + DPD I
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM-WGLYEG---QQP---MLVIMDPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    L      +W R+R++    FTS +  
Sbjct: 91  KTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK-F 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKN-DFLTFLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++++  +SK+ +   F     +++I    F    +S   + QD
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P  ++ K +      +  ++ +    L+  F TP+++ L N  ++ + + T  L   I  
Sbjct: 202 PFLKNMKKLLKLDFLDPFLLLIS---LFP-FLTPVFEAL-NIGLFPKDV-THFLKNSIER 255

Query: 288 FESDDSKNDKSLLKTFLQQ--------PQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K+ +     F QQ            HK     +++   + I+ AA DTT+ T  
Sbjct: 256 MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KDI + G  IPKG  ++         P++  +P  F PE         ++I  +  
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF-SKKNKDSIDLYRY 433

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
           +PFG GPR+CI  R A  NI + ++R ++ F  +   E    L +  L I +P KP+ L
Sbjct: 434 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 492


>AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.
          Length = 504

 Score =  122 bits (295), Expect = 2e-27
 Identities = 119/479 (24%), Positives = 212/479 (44%), Gaps = 41/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +GT+  YL  + ++D E  +K   + W  Y     ++P   ++ + DPD I
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM-WGLYEG---QQP---MLVIMDPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    L      +W R+R++    FTS +  
Sbjct: 91  KTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK-F 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKN-DFLTFLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++++  +SK+ +   F     +++I    F    +S   + QD
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P  ++ K +      +  ++ +    L+  F TP+++ L N  ++ + + T  L   I  
Sbjct: 202 PFLKNMKKLLKLDFLDPFLLLIS---LFP-FLTPVFEAL-NIGLFPKDV-THFLKNSIER 255

Query: 288 FESDDSKNDKSLLKTFLQQ--------PQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K+ +     F QQ            HK     +++   + I+ AA DTT+ T  
Sbjct: 256 MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KDI + G  IPKG  ++         P++  +P  F PE         ++I  +  
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF-SKKNKDSIDLYRY 433

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
           +PFG GPR+CI  R A  NI + ++R ++ F  +   E    L +  L I +P KP+ L
Sbjct: 434 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 492


>D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa
           protein.
          Length = 503

 Score =  120 bits (290), Expect = 9e-27
 Identities = 111/454 (24%), Positives = 205/454 (45%), Gaps = 39/454 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G    +      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKV-WGIYDC---QQPMLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W R+RS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTFL-NRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L  +    ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +  V+ + K F    F TP+ + L N  ++  K+ +  L + +  
Sbjct: 202 PFVENTKKLLRFNPLDPFVLSI-KVF---PFLTPILEAL-NITVFPRKVIS-FLTKSVKQ 255

Query: 288 FESDDSKNDKSLLKTFLQ-----QPQLD---HK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K  +     FLQ     Q   D   HK     ++M   +  + A  +TT+   S
Sbjct: 256 IKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ +E+ T+LP K    T D + +  Y+   + E+LRL PV++ + 
Sbjct: 316 FIIYELATHPDVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +      P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            PFG GPR+CI  R A  N+ + L+R+++ F  +
Sbjct: 433 TPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466


>BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 7 protein.
          Length = 503

 Score =  120 bits (290), Expect = 9e-27
 Identities = 111/454 (24%), Positives = 205/454 (45%), Gaps = 39/454 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G    +      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKV-WGIYDC---QQPMLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W R+RS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTFL-NRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L  +    ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +  V+ + K F    F TP+ + L N  ++  K+ +  L + +  
Sbjct: 202 PFVENTKKLLRFNPLDPFVLSI-KVF---PFLTPILEAL-NITVFPRKVIS-FLTKSVKQ 255

Query: 288 FESDDSKNDKSLLKTFLQ-----QPQLD---HK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K  +     FLQ     Q   D   HK     ++M   +  + A  +TT+   S
Sbjct: 256 IKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ +E+ T+LP K    T D + +  Y+   + E+LRL PV++ + 
Sbjct: 316 FIIYELATHPDVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +      P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            PFG GPR+CI  R A  N+ + L+R+++ F  +
Sbjct: 433 TPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466


>AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant
           3A7 protein.
          Length = 535

 Score =  120 bits (290), Expect = 9e-27
 Identities = 111/454 (24%), Positives = 205/454 (45%), Gaps = 39/454 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G    +      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKV-WGIYDC---QQPMLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W R+RS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTFL-NRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L  +    ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +  V+ + K F    F TP+ + L N  ++  K+ +  L + +  
Sbjct: 202 PFVENTKKLLRFNPLDPFVLSI-KVF---PFLTPILEAL-NITVFPRKVIS-FLTKSVKQ 255

Query: 288 FESDDSKNDKSLLKTFLQ-----QPQLD---HK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K  +     FLQ     Q   D   HK     ++M   +  + A  +TT+   S
Sbjct: 256 IKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ +E+ T+LP K    T D + +  Y+   + E+LRL PV++ + 
Sbjct: 316 FIIYELATHPDVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +      P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            PFG GPR+CI  R A  N+ + L+R+++ F  +
Sbjct: 433 TPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466


>AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450
           polypeptide 7 protein.
          Length = 503

 Score =  120 bits (290), Expect = 9e-27
 Identities = 111/454 (24%), Positives = 205/454 (45%), Gaps = 39/454 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G    +      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKV-WGIYDC---QQPMLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W R+RS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTFL-NRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L  +    ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +  V+ + K F    F TP+ + L N  ++  K+ +  L + +  
Sbjct: 202 PFVENTKKLLRFNPLDPFVLSI-KVF---PFLTPILEAL-NITVFPRKVIS-FLTKSVKQ 255

Query: 288 FESDDSKNDKSLLKTFLQ-----QPQLD---HK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K  +     FLQ     Q   D   HK     ++M   +  + A  +TT+   S
Sbjct: 256 IKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ +E+ T+LP K    T D + +  Y+   + E+LRL PV++ + 
Sbjct: 316 FIIYELATHPDVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRLFPVAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +      P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            PFG GPR+CI  R A  N+ + L+R+++ F  +
Sbjct: 433 TPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466


>M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA
           encoding nifedipine oxidase, complete cds. ).
          Length = 503

 Score =  119 bits (286), Expect = 3e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family 3
           subfamily A polypeptide 4 protein.
          Length = 503

 Score =  119 bits (286), Expect = 3e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score =  119 bits (286), Expect = 3e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfamily
           IIIA, polypeptide 4 protein.
          Length = 503

 Score =  119 bits (286), Expect = 3e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score =  119 bits (286), Expect = 3e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.
          Length = 503

 Score =  119 bits (286), Expect = 3e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450
           polypeptide 4 protein.
          Length = 503

 Score =  119 bits (286), Expect = 3e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4
           protein.
          Length = 503

 Score =  119 bits (286), Expect = 3e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4
           protein.
          Length = 503

 Score =  119 bits (286), Expect = 3e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGCETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for
           cytochrome P-450 (cyp3 locus). ).
          Length = 503

 Score =  118 bits (284), Expect = 5e-26
 Identities = 113/479 (23%), Positives = 215/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++ 
Sbjct: 375 RVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>X55764-1|CAA39290.1|  503|Homo sapiens protein ( Human mRNA for
           cytochrome P-450 (11 Beta). ).
          Length = 503

 Score =  118 bits (283), Expect = 7e-26
 Identities = 91/402 (22%), Positives = 175/402 (43%), Gaps = 17/402 (4%)

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
           +V V  P+D+E + + D  +P R S      YR ++ +     G+   NGP+W   R   
Sbjct: 88  MVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKC---GVFLLNGPEWRFNRLRL 144

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF-----LNRLNLEIIGVVA 213
                SP +V+  +   D +A++F + +K+  + +    LT      +    +E   +  
Sbjct: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204

Query: 214 FNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYL 273
           F ER      S           +   F S   +M + +  L +  S  ++K+   +   +
Sbjct: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWTSPKVWKEHFEAWDCI 263

Query: 274 EKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTT 333
            +   + + +          +   S++   L   +L    I    +++   ++DTT +  
Sbjct: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 323

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
              L+ +ARN   Q  + +E          E      ++   +R+++KE+LRL PV + +
Sbjct: 324 LMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWM--RGSPQYETIHP 451
            R +  D+VL+ Y IP GT++     +  R P     P  + P+RW+  RGS +      
Sbjct: 383 ERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGR-----N 437

Query: 452 FLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
           F  +PFG G R C+ RRLAE  + ++L  +++  +++   +E
Sbjct: 438 FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE 479


>M32879-1|AAA52149.1|  503|Homo sapiens CYP11B1 protein.
          Length = 503

 Score =  117 bits (281), Expect = 1e-25
 Identities = 91/402 (22%), Positives = 174/402 (43%), Gaps = 17/402 (4%)

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
           +V V  P+D+E + + D  +P R S      YR ++ +     G+   NGP+W   R   
Sbjct: 88  MVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKC---GVFLLNGPEWRFNRLRL 144

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF-----LNRLNLEIIGVVA 213
                SP +V+  +   D +A++F + +K+  + +    LT      +    +E   +  
Sbjct: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204

Query: 214 FNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYL 273
           F ER      S           +   F S   +M + +  L +  S  ++K+   +   +
Sbjct: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWTSPKVWKEHFEAWDCI 263

Query: 274 EKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTT 333
            +   + + +          +   S++   L   +L    I    +++   ++DTT +  
Sbjct: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 323

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
              L+ +ARN   Q  + +E          E      ++   +R+++KE+LRL PV + +
Sbjct: 324 LMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWM--RGSPQYETIHP 451
            R    D+VL+ Y IP GT++     +  R P     P  + P+RW+  RGS +      
Sbjct: 383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGR-----N 437

Query: 452 FLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
           F  +PFG G R C+ RRLAE  + ++L  +++  +++   +E
Sbjct: 438 FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE 479


>M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrome
           P-450 nifedipine oxidase mRNA, complet cds. ).
          Length = 503

 Score =  117 bits (281), Expect = 1e-25
 Identities = 113/479 (23%), Positives = 214/479 (44%), Gaps = 42/479 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PFVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKSVKR 255

Query: 288 FESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   S
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLS 454
           R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P+  
Sbjct: 375 RVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYTY 432

Query: 455 LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
            PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491


>BC096287-1|AAH96287.1|  503|Homo sapiens cytochrome P450, family
           11, subfamily B, polypeptide 1 protein.
          Length = 503

 Score =  117 bits (281), Expect = 1e-25
 Identities = 91/402 (22%), Positives = 174/402 (43%), Gaps = 17/402 (4%)

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
           +V V  P+D+E + + D  +P R S      YR ++ +     G+   NGP+W   R   
Sbjct: 88  MVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKC---GVFLLNGPEWRFNRLRL 144

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF-----LNRLNLEIIGVVA 213
                SP +V+  +   D +A++F + +K+  + +    LT      +    +E   +  
Sbjct: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204

Query: 214 FNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYL 273
           F ER      S           +   F S   +M + +  L +  S  ++K+   +   +
Sbjct: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWTSPKVWKEHFEAWDCI 263

Query: 274 EKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTT 333
            +   + + +          +   S++   L   +L    I    +++   ++DTT +  
Sbjct: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 323

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
              L+ +ARN   Q  + +E          E      ++   +R+++KE+LRL PV + +
Sbjct: 324 LMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWM--RGSPQYETIHP 451
            R    D+VL+ Y IP GT++     +  R P     P  + P+RW+  RGS +      
Sbjct: 383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGR-----N 437

Query: 452 FLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
           F  +PFG G R C+ RRLAE  + ++L  +++  +++   +E
Sbjct: 438 FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE 479


>J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipine
           oxidase protein.
          Length = 502

 Score =  116 bits (280), Expect = 2e-25
 Identities = 115/480 (23%), Positives = 216/480 (45%), Gaps = 45/480 (9%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K      +  G    ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYG----KVCGFYDGQQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++     R   P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KTVL-------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R+  + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPL-YKKLVNSQIYLEKISTDILIRKIN 286
           P   ++K +   F        LD  FL  +F   +   +++N  ++  ++ T+ L + + 
Sbjct: 202 PFVENTKKLLR-FDF------LDPFFLSIIFPFLIPILEVLNICVFPREV-TNFLRKSVK 253

Query: 287 LFESDDSKNDKSLLKTFLQ--------QPQLDHK-----DIMGMMVDILMAAIDTTAYTT 333
             +    ++ +     FLQ        +    HK     +++   +  + A  +TT+   
Sbjct: 254 RMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVL 313

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           SF++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ +
Sbjct: 314 SFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRL 372

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P+ 
Sbjct: 373 ERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYT 430

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
             PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 431 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 490


>AF478474-1|AAL84813.1|  503|Homo sapiens mutated cytochrome
           P-450c11 protein protein.
          Length = 503

 Score =  116 bits (279), Expect = 2e-25
 Identities = 91/402 (22%), Positives = 174/402 (43%), Gaps = 17/402 (4%)

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
           +V V  P+D+E + + D  +P R S      YR ++ +     G+   NGP+W   R   
Sbjct: 88  MVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKC---GVFLLNGPEWRFNRLRL 144

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF-----LNRLNLEIIGVVA 213
                SP +V+  +   D +A++F + +K+  + +    LT      +    +E   +  
Sbjct: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204

Query: 214 FNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYL 273
           F ER      S           +   F S   +M + +  L +  S  ++K+   +   +
Sbjct: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWTSPKVWKEHFEAWDCI 263

Query: 274 EKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTT 333
            +   + + +          +   S++   L   +L    I    +++   ++DTT +  
Sbjct: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSMDTTVFPL 323

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
              L+ +ARN   Q  + +E          E      ++   +R+++KE+LRL PV + +
Sbjct: 324 LMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWM--RGSPQYETIHP 451
            R    D+VL+ Y IP GT++     +  R P     P  + P+RW+  RGS +      
Sbjct: 383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGR-----N 437

Query: 452 FLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
           F  +PFG G R C+ RRLAE  + ++L  +++  +++   +E
Sbjct: 438 FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE 479


>M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver
           glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
           complete cds. ).
          Length = 504

 Score =  115 bits (277), Expect = 4e-25
 Identities = 112/480 (23%), Positives = 214/480 (44%), Gaps = 43/480 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KLVL-------VKECYSVFTNREPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R++ + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDVITSSSFGVNVDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PLVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKAVKR 255

Query: 288 FESDDSKNDKSLLKTFLQQPQLDHK--------------DIMGMMVDILMAAIDTTAYTT 333
            +    ++ +     FLQ     HK              +++   +  + A  +TT+   
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSIIFIFAGYETTSSVL 315

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           SF++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ +
Sbjct: 316 SFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRL 374

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++
Sbjct: 375 ERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYI 432

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
             PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 492


>D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.
          Length = 504

 Score =  115 bits (277), Expect = 4e-25
 Identities = 112/480 (23%), Positives = 214/480 (44%), Gaps = 43/480 (8%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +G +  Y      +D E   K   + W  Y     ++P++ +    DPD I
Sbjct: 38  IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV-WGFYDG---QQPVLAIT---DPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    +      +W RLRS+    FTS + +
Sbjct: 91  KLVL-------VKECYSVFTNREPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK-L 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKNDFLT-FLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++R++ + K   L       ++++I   +F    +S   + QD
Sbjct: 143 KEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDVITSSSFGVNVDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P   ++K +      +   + +        F  P+ + L N  ++  ++ T+ L + +  
Sbjct: 202 PLVENTKKLLRFDFLDPFFLSITVF----PFLIPILEVL-NICVFPREV-TNFLRKAVKR 255

Query: 288 FESDDSKNDKSLLKTFLQQPQLDHK--------------DIMGMMVDILMAAIDTTAYTT 333
            +    ++ +     FLQ     HK              +++   +  + A  +TT+   
Sbjct: 256 MKESRLEDTQKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSIIFIFAGYETTSSVL 315

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           SF++Y +A +   Q ++ EE+  +LP K    T D + +  Y+   + E+LRL P+++ +
Sbjct: 316 SFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRL 374

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +KD+ + G  IPKG V++  +    R P++  +P  F PER+ + +   + I P++
Sbjct: 375 ERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYI 432

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE-ELGVKTLL--INKPNKPVSL 510
             PFG GPR+CI  R A  N+ + L+R+++ F  +   E ++ +K  L  + +P KPV L
Sbjct: 433 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 492


>D13752-1|BAA02899.1|  503|Homo sapiens steroid 18-hydroxylase
           protein.
          Length = 503

 Score =  114 bits (275), Expect = 6e-25
 Identities = 90/402 (22%), Positives = 179/402 (44%), Gaps = 17/402 (4%)

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
           +V V  P+D+E + + D  +P R        YR ++ +     G+   NGP+W   R   
Sbjct: 88  MVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKC---GVFLLNGPEWRFNRLRL 144

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF-----LNRLNLEIIGVVA 213
             +  SP++V+  +   D +A++F + +K+  + +    LT      +    +E   +  
Sbjct: 145 NPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204

Query: 214 FNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYL 273
           F ER      S           +   F S   +M + +  L +  S  ++K+   +   +
Sbjct: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWISPKVWKEHFEAWDCI 263

Query: 274 EKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTT 333
            +   + + +       +  ++   ++   L + +L  + I    +++   ++DTTA+  
Sbjct: 264 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 323

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
              L+ +ARN   Q  + +E          E      ++   +R+++KE+LRL PV + +
Sbjct: 324 LMTLFELARNPDVQQILRQE-SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWM--RGSPQYETIHP 451
            R +  D+VL+ Y IP GT++     +  R       P  + P+RW+  RGS +      
Sbjct: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGR-----N 437

Query: 452 FLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
           F  +PFG G R C+ RRLAE  + ++L  +++ F ++   +E
Sbjct: 438 FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE 479


>AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.
          Length = 353

 Score =  113 bits (271), Expect = 2e-24
 Identities = 62/205 (30%), Positives = 114/205 (55%), Gaps = 6/205 (2%)

Query: 309 LDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITAD 368
           L   +++   +  + A  +TT+   SF++Y +A +   Q ++ EE+  +LP K    T D
Sbjct: 140 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYD 198

Query: 369 VLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFI 428
            + +  Y+   + E+LRL P+++ + R  +KD+ + G  IPKG V++  +    R P++ 
Sbjct: 199 TVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 258

Query: 429 RDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            +P  F PER+ + +   + I P++  PFG GPR+CI  R A  N+ + L+R+++ F  +
Sbjct: 259 TEPEKFLPERFSKKNK--DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 316

Query: 489 WAGE-ELGVKTLL--INKPNKPVSL 510
              E ++ +K  L  + +P KPV L
Sbjct: 317 PCKETQIPLKLSLGGLLQPEKPVVL 341


>AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.
          Length = 430

 Score =  113 bits (271), Expect = 2e-24
 Identities = 62/205 (30%), Positives = 114/205 (55%), Gaps = 6/205 (2%)

Query: 309 LDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITAD 368
           L   +++   +  + A  +TT+   SF++Y +A +   Q ++ EE+  +LP K    T D
Sbjct: 217 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYD 275

Query: 369 VLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFI 428
            + +  Y+   + E+LRL P+++ + R  +KD+ + G  IPKG V++  +    R P++ 
Sbjct: 276 TVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 335

Query: 429 RDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            +P  F PER+ + +   + I P++  PFG GPR+CI  R A  N+ + L+R+++ F  +
Sbjct: 336 TEPEKFLPERFSKKNK--DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 393

Query: 489 WAGE-ELGVKTLL--INKPNKPVSL 510
              E ++ +K  L  + +P KPV L
Sbjct: 394 PCKETQIPLKLSLGGLLQPEKPVVL 418


>X54741-1|CAA38539.1|  503|Homo sapiens aldosterone  synthase
           (P-450aldo) protein.
          Length = 503

 Score =  112 bits (270), Expect = 2e-24
 Identities = 89/402 (22%), Positives = 178/402 (44%), Gaps = 17/402 (4%)

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
           +V V  P+D+E + + D  +P R        YR ++ +     G+   NGP+W   R   
Sbjct: 88  MVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKC---GVFLLNGPEWRFNRLRL 144

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF-----LNRLNLEIIGVVA 213
             +  SP++V+  +   D +A++F + +K+  + +    LT      +    +E   +  
Sbjct: 145 NPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204

Query: 214 FNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYL 273
           F ER      S           +   F S   +M + +  L +     ++K+   +   +
Sbjct: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWIRPKVWKEHFEAWDCI 263

Query: 274 EKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTT 333
            +   + + +       +  ++   ++   L + +L  + I    +++   ++DTTA+  
Sbjct: 264 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 323

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
              L+ +ARN   Q  + +E          E      ++   +R+++KE+LRL PV + +
Sbjct: 324 LMTLFELARNPDVQQILRQE-SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWM--RGSPQYETIHP 451
            R +  D+VL+ Y IP GT++     +  R       P  + P+RW+  RGS +      
Sbjct: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGR-----N 437

Query: 452 FLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
           F  +PFG G R C+ RRLAE  + ++L  +++ F ++   +E
Sbjct: 438 FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE 479


>M32881-1|AAA35741.1|  503|Homo sapiens protein ( Human steroid
           11-beta-hydroxylase-like-enzyme (CYP11B2) gene, exon 9.
           ).
          Length = 503

 Score =  110 bits (265), Expect = 1e-23
 Identities = 89/403 (22%), Positives = 179/403 (44%), Gaps = 19/403 (4%)

Query: 99  LVHVYDPDDIEAVFRQDHRYPAR---RSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLR 155
           +V V  P+D+E + + D  +P R       A+  +R +K  V+    LL  NGP+W   R
Sbjct: 88  MVCVMLPEDVEKLQQVDSLHPCRMILEPWVAIRQHRGHKCGVF----LL--NGPEWRFNR 141

Query: 156 SIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF-----LNRLNLEIIG 210
                +  SP++V+  +   D +A++F + +++  + +    LT      +    +E   
Sbjct: 142 LRLNPDVLSPKAVQRFLPMVDAVARDFSQALRKKVLQNARGSLTLDVQPSIFHYTIEASN 201

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +  F ER      S           +   F S   +M + +  L +  S  ++K+   + 
Sbjct: 202 LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWISPKVWKEHFEAW 260

Query: 271 IYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTA 330
             + +   + + +       +  ++   ++   L + +L  + I    +++   ++DTTA
Sbjct: 261 DCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTA 320

Query: 331 YTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS 390
           +     L+ +ARN   Q  + +E          E      ++   +R+++KE+LRL PV 
Sbjct: 321 FPLLMTLFELARNPDVQQILRKE-SLAAAASISEHPQKATTELPLLRAALKETLRLYPVG 379

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + + R +  D+VL+ Y IP GT++     +  R       P  + P+RW+        +H
Sbjct: 380 LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNLH 439

Query: 451 PFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
               +PFG G R C+ RRLAE  + ++L  +++ F ++   +E
Sbjct: 440 ---HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKRFLVETLTQE 479


>BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.
          Length = 393

 Score =  109 bits (263), Expect = 2e-23
 Identities = 70/227 (30%), Positives = 117/227 (51%), Gaps = 13/227 (5%)

Query: 287 LFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRC 346
           + +S +SK  KS          L   +++   + I+ AA DTT+ T  F++Y +A +   
Sbjct: 165 MIDSQNSKETKS-------HKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDV 217

Query: 347 QDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGY 406
           Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + R  +KDI + G 
Sbjct: 218 QQKLQEEIDAVLPNKAP-VTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGV 276

Query: 407 SIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIA 466
            IPKG  ++         P++  +P  F PER+ + +   ++I  +  +PFG GPR+CI 
Sbjct: 277 FIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNK--DSIDLYRYIPFGAGPRNCIG 334

Query: 467 RRLAEQNICIILMRLIREFEIQWAGE---ELGVKTLLINKPNKPVSL 510
            R A  NI + ++R ++ F  +   E    L +  L I +P KP+ L
Sbjct: 335 MRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 381


>BC096285-1|AAH96285.1|  574|Homo sapiens CYP11B1 protein protein.
          Length = 574

 Score =  106 bits (254), Expect = 2e-22
 Identities = 79/354 (22%), Positives = 152/354 (42%), Gaps = 14/354 (3%)

Query: 147 NGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF-----L 201
           NGP+W   R        SP +V+  +   D +A++F + +K+  + +    LT      +
Sbjct: 204 NGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI 263

Query: 202 NRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTP 261
               +E   +  F ER      S           +   F S   +M + +  L +  S  
Sbjct: 264 FHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWTSPK 322

Query: 262 LYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDI 321
           ++K+   +   + +   + + +          +   S++   L   +L    I    +++
Sbjct: 323 VWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMEL 382

Query: 322 LMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIK 381
              ++DTT +     L+ +ARN   Q  + +E          E      ++   +R+++K
Sbjct: 383 TAGSVDTTVFPLLMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALK 441

Query: 382 ESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWM- 440
           E+LRL PV + + R    D+VL+ Y IP GT++     +  R P     P  + P+RW+ 
Sbjct: 442 ETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLD 501

Query: 441 -RGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEE 493
            RGS +      F  +PFG G R C+ RRLAE  + ++L  +++  +++   +E
Sbjct: 502 IRGSGR-----NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE 550


>BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family 4,
           subfamily V, polypeptide 2 protein.
          Length = 525

 Score =  101 bits (243), Expect = 5e-21
 Identities = 66/212 (31%), Positives = 104/212 (49%), Gaps = 4/212 (1%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L H+DI   +   +    DTTA   ++ LY +  N   Q ++  EL  +  K D   T 
Sbjct: 313 RLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATV 372

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQF 427
           + L K  Y+   IKE+LRL P      R + +D  + GY + KGT  V       R P++
Sbjct: 373 EDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRY 432

Query: 428 IRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF-- 485
             +P  F+PER+   + Q    HP+  +PF  GPR+CI ++ A      IL  ++R F  
Sbjct: 433 FPNPEEFQPERFFPENAQGR--HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWI 490

Query: 486 EIQWAGEELGVKTLLINKPNKPVSLNFIPRSS 517
           E     EELG++  LI +P+  + +    R++
Sbjct: 491 ESNQKREELGLEGQLILRPSNGIWIKLKRRNA 522


>AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2
           protein.
          Length = 525

 Score =  101 bits (243), Expect = 5e-21
 Identities = 66/212 (31%), Positives = 104/212 (49%), Gaps = 4/212 (1%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L H+DI   +   +    DTTA   ++ LY +  N   Q ++  EL  +  K D   T 
Sbjct: 313 RLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATV 372

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQF 427
           + L K  Y+   IKE+LRL P      R + +D  + GY + KGT  V       R P++
Sbjct: 373 EDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRY 432

Query: 428 IRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF-- 485
             +P  F+PER+   + Q    HP+  +PF  GPR+CI ++ A      IL  ++R F  
Sbjct: 433 FPNPEEFQPERFFPENAQGR--HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWI 490

Query: 486 EIQWAGEELGVKTLLINKPNKPVSLNFIPRSS 517
           E     EELG++  LI +P+  + +    R++
Sbjct: 491 ESNQKREELGLEGQLILRPSNGIWIKLKRRNA 522


>AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens
           cDNA FLJ44509 fis, clone UTERU3001585, weakly  similar
           to Cytochrome P450 4c3 (EC 1.14.-.-). ).
          Length = 503

 Score =  101 bits (243), Expect = 5e-21
 Identities = 66/212 (31%), Positives = 104/212 (49%), Gaps = 4/212 (1%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L H+DI   +   +    DTTA   ++ LY +  N   Q ++  EL  +  K D   T 
Sbjct: 291 RLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATV 350

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQF 427
           + L K  Y+   IKE+LRL P      R + +D  + GY + KGT  V       R P++
Sbjct: 351 EDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRY 410

Query: 428 IRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF-- 485
             +P  F+PER+   + Q    HP+  +PF  GPR+CI ++ A      IL  ++R F  
Sbjct: 411 FPNPEEFQPERFFPENAQGR--HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWI 468

Query: 486 EIQWAGEELGVKTLLINKPNKPVSLNFIPRSS 517
           E     EELG++  LI +P+  + +    R++
Sbjct: 469 ESNQKREELGLEGQLILRPSNGIWIKLKRRNA 500


>AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens
           cDNA FLJ16007 fis, clone KIDNE2006580, weakly  similar
           to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
          Length = 525

 Score =  101 bits (243), Expect = 5e-21
 Identities = 66/212 (31%), Positives = 104/212 (49%), Gaps = 4/212 (1%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L H+DI   +   +    DTTA   ++ LY +  N   Q ++  EL  +  K D   T 
Sbjct: 313 RLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATV 372

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQF 427
           + L K  Y+   IKE+LRL P      R + +D  + GY + KGT  V       R P++
Sbjct: 373 EDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRY 432

Query: 428 IRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF-- 485
             +P  F+PER+   + Q    HP+  +PF  GPR+CI ++ A      IL  ++R F  
Sbjct: 433 FPNPEEFQPERFFPENAQGR--HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWI 490

Query: 486 EIQWAGEELGVKTLLINKPNKPVSLNFIPRSS 517
           E     EELG++  LI +P+  + +    R++
Sbjct: 491 ESNQKREELGLEGQLILRPSNGIWIKLKRRNA 522


>BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family
           46, subfamily A, polypeptide 1 protein.
          Length = 500

 Score = 97.1 bits (231), Expect = 1e-19
 Identities = 106/481 (22%), Positives = 207/481 (43%), Gaps = 32/481 (6%)

Query: 46  FEDIPGPRSYPIIGTLHKYLPLIGDYDAEA--LDKNAILNW-RRYGSLVREKPIVNL-VH 101
           +E IPGP   P    L  +LP     D     + ++  L+W ++YG +VR        V 
Sbjct: 30  YEHIPGP---PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVI 86

Query: 102 VYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKN 161
           V  P+ ++            + + A+      +  ++  G +   N   W + R +    
Sbjct: 87  VTSPESVKKFLMSTKYNKDSKMYRALQTVFGER--LFGQGLVSECNYERWHKQRRVIDLA 144

Query: 162 FTSPQSVKTHVSDTDNIAKEFVEWI--KRDKVS--SKNDFLTFLNRLNLEIIGVVAFNER 217
           F S  S+ + +   +  A++ VE +  K D  +  S  D LT+     ++I+   AF   
Sbjct: 145 F-SRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTA---MDILAKAAFGME 200

Query: 218 FNSFALSEQDPESRSSKTIAAAF-GSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKI 276
             S  L  Q P S++ K +      S + + K   G   ++      +++  S  +L ++
Sbjct: 201 -TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL------REVRESIRFLRQV 253

Query: 277 STDILIRKINLFESDDSKNDKSLLKTF-LQQPQLDHKDIMGMMVDILMAAIDTTAYTTSF 335
             D + R+    +  +      L +    ++   D + ++   V   +A  +T+A   +F
Sbjct: 254 GRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAF 313

Query: 336 VLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGR 395
            +  ++R       +  E+  ++  K   +  + L +  Y+   +KESLRL P + G  R
Sbjct: 314 TVMELSRQPEIVARLQAEVDEVIGSKR-YLDFEDLGRLQYLSQVLKESLRLYPPAWGTFR 372

Query: 396 WLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSL 455
            L+++ ++ G  +P  T ++       R+  +  DPLTF P+R+  G+P+      F   
Sbjct: 373 LLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR----FTYF 428

Query: 456 PFGHGPRSCIARRLAEQNICIILMRLIREFEIQWA-GEELGVKTLLINKPNKPVSLNFIP 514
           PF  G RSCI ++ A+  + +++ +L++  E +   G+  G++     KP  PV     P
Sbjct: 429 PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488

Query: 515 R 515
           R
Sbjct: 489 R 489


>AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxylase
           protein.
          Length = 500

 Score = 97.1 bits (231), Expect = 1e-19
 Identities = 106/481 (22%), Positives = 207/481 (43%), Gaps = 32/481 (6%)

Query: 46  FEDIPGPRSYPIIGTLHKYLPLIGDYDAEA--LDKNAILNW-RRYGSLVREKPIVNL-VH 101
           +E IPGP   P    L  +LP     D     + ++  L+W ++YG +VR        V 
Sbjct: 30  YEHIPGP---PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVI 86

Query: 102 VYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKN 161
           V  P+ ++            + + A+      +  ++  G +   N   W + R +    
Sbjct: 87  VTSPESVKKFLMSTKYNKDSKMYRALQTVFGER--LFGQGLVSECNYERWHKQRRVIDLA 144

Query: 162 FTSPQSVKTHVSDTDNIAKEFVEWI--KRDKVS--SKNDFLTFLNRLNLEIIGVVAFNER 217
           F S  S+ + +   +  A++ VE +  K D  +  S  D LT+     ++I+   AF   
Sbjct: 145 F-SRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTA---MDILAKAAFGME 200

Query: 218 FNSFALSEQDPESRSSKTIAAAF-GSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKI 276
             S  L  Q P S++ K +      S + + K   G   ++      +++  S  +L ++
Sbjct: 201 -TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL------REVRESIRFLRQV 253

Query: 277 STDILIRKINLFESDDSKNDKSLLKTF-LQQPQLDHKDIMGMMVDILMAAIDTTAYTTSF 335
             D + R+    +  +      L +    ++   D + ++   V   +A  +T+A   +F
Sbjct: 254 GRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAF 313

Query: 336 VLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGR 395
            +  ++R       +  E+  ++  K   +  + L +  Y+   +KESLRL P + G  R
Sbjct: 314 TVMELSRQPEIVARLQAEVDEVIGSKR-YLDFEDLGRLQYLSQVLKESLRLYPPAWGTFR 372

Query: 396 WLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSL 455
            L+++ ++ G  +P  T ++       R+  +  DPLTF P+R+  G+P+      F   
Sbjct: 373 LLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR----FTYF 428

Query: 456 PFGHGPRSCIARRLAEQNICIILMRLIREFEIQWA-GEELGVKTLLINKPNKPVSLNFIP 514
           PF  G RSCI ++ A+  + +++ +L++  E +   G+  G++     KP  PV     P
Sbjct: 429 PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488

Query: 515 R 515
           R
Sbjct: 489 R 489


>AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 420

 Score = 94.7 bits (225), Expect = 7e-19
 Identities = 97/404 (24%), Positives = 176/404 (43%), Gaps = 37/404 (9%)

Query: 49  IPGPRSYPIIGTLHKYLPLIGDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDI 108
           IPGP   P +GT+  YL  + ++D E  +K   + W  Y     ++P   ++ + DPD I
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEM-WGLYEG---QQP---MLVIMDPDMI 90

Query: 109 EAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQKNFTSPQSV 168
           + V         +  ++         P  +    L      +W R+R++    FTS +  
Sbjct: 91  KTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK-F 142

Query: 169 KTHVSDTDNIAKEFVEWIKRDKVSSKN-DFLTFLNRLNLEIIGVVAFNERFNSFALSEQD 227
           K  V          V  ++++  +SK+ +   F     +++I    F    +S   + QD
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN-NPQD 201

Query: 228 PESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEKISTDILIRKINL 287
           P  ++ K +      +  ++ +    L+  F TP+++ L N  ++ + + T  L   I  
Sbjct: 202 PFLKNMKKLLKLDFLDPFLLLIS---LFP-FLTPVFEAL-NIGLFPKDV-THFLKNSIER 255

Query: 288 FESDDSKNDKSLLKTFLQQ--------PQLDHK-----DIMGMMVDILMAAIDTTAYTTS 334
            +    K+ +     F QQ            HK     +++   + I+ AA DTT+ T  
Sbjct: 256 MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 335 FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIG 394
           F++Y +A +   Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

Query: 395 RWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPER 438
           R  +KDI + G  IPKG  ++         P++  +P  F PER
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>AY280372-1|AAQ21368.1|  519|Homo sapiens cytochrome P450 4A22
           protein.
          Length = 519

 Score = 91.9 bits (218), Expect = 5e-18
 Identities = 102/400 (25%), Positives = 167/400 (41%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   Y+   P +  +  LL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDS----KSHGS---YKFLAPWIGYS--LLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEII--------G 210
             F     +K +V    D++     +W +     S  +F   ++ + L+ I        G
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEFFQHVSLMTLDTIMKSAFSHQG 206

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
            +  +    S+  +  D  S     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLSSLVFCRMRNAFHENDAIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  + T+  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQTEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHGLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480


>S67581-1|AAB29503.1|  591|Homo sapiens fatty acid omega-hydroxylase
           protein.
          Length = 591

 Score = 91.1 bits (216), Expect = 9e-18
 Identities = 102/400 (25%), Positives = 168/400 (42%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480


>S67580-1|AAB29502.1|  519|Homo sapiens fatty acid omega-hydroxylase
           protein.
          Length = 519

 Score = 91.1 bits (216), Expect = 9e-18
 Identities = 102/400 (25%), Positives = 168/400 (42%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480


>L04751-1|AAA58436.1|  519|Homo sapiens cytochrome P450 protein.
          Length = 519

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 102/400 (25%), Positives = 168/400 (42%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480


>D26481-1|BAA05491.1|  519|Homo sapiens fatty acids
           omega-hydroxylase protein.
          Length = 519

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 102/400 (25%), Positives = 168/400 (42%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480


>AY369778-1|AAQ56847.1|  519|Homo sapiens cytochrome P450, family 4,
           subfamily A, polypeptide 11 protein.
          Length = 519

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 102/400 (25%), Positives = 168/400 (42%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480


>AL731892-3|CAH72778.1|  519|Homo sapiens cytochrome P450, family 4,
           subfamily A, polypeptide 11 protein.
          Length = 519

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 102/400 (25%), Positives = 168/400 (42%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480


>AJ563378-3|CAD91347.1|  173|Homo sapiens hypothetical protein
           protein.
          Length = 173

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 49/148 (33%), Positives = 84/148 (56%), Gaps = 6/148 (4%)

Query: 366 TADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLP 425
           T D + +  Y+   + E+LRL PV+I + R  +KD+ + G  IPKG+++V         P
Sbjct: 17  TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDP 76

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
           ++  +P  F+PER+   S + ++I P++  PFG GPR+CI  R A  N+ + L+R+++ F
Sbjct: 77  KYWTEPEEFRPERF---SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 133

Query: 486 EIQWAGE---ELGVKTLLINKPNKPVSL 510
             +   E    L + T  + +P KP+ L
Sbjct: 134 SFKPCKETQIPLKLDTQGLLQPEKPIVL 161


>AJ563378-2|CAD91647.1|  160|Homo sapiens cytochrome P450 protein.
          Length = 160

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 49/148 (33%), Positives = 84/148 (56%), Gaps = 6/148 (4%)

Query: 366 TADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLP 425
           T D + +  Y+   + E+LRL PV+I + R  +KD+ + G  IPKG+++V         P
Sbjct: 4   TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDP 63

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
           ++  +P  F+PER+   S + ++I P++  PFG GPR+CI  R A  N+ + L+R+++ F
Sbjct: 64  KYWTEPEEFRPERF---SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 120

Query: 486 EIQWAGE---ELGVKTLLINKPNKPVSL 510
             +   E    L + T  + +P KP+ L
Sbjct: 121 SFKPCKETQIPLKLDTQGLLQPEKPIVL 148


>AF525488-1|AAO16078.1|  519|Homo sapiens cytochrome P450, subfamily
           IVA, polypeptide 11 protein.
          Length = 519

 Score = 89.4 bits (212), Expect = 3e-17
 Identities = 102/400 (25%), Positives = 168/400 (42%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLFP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480


>AY280371-1|AAQ21367.1|  519|Homo sapiens cytochrome P450 4A22K
           protein.
          Length = 519

 Score = 89.0 bits (211), Expect = 3e-17
 Identities = 100/400 (25%), Positives = 167/400 (41%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   Y+   P +  +  LL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YKFLAPWIGYS--LLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEII--------G 210
             F     +K +V    D++     +W +     S  +F   ++ + L+ I        G
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEFFQHVSLMTLDTIMKSAFSHQG 206

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
            +  +    S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480


>AF208532-1|AAF76722.1|  519|Homo sapiens fatty acid
           omega-hydroxylase CYP4A11 protein.
          Length = 519

 Score = 87.4 bits (207), Expect = 1e-16
 Identities = 101/400 (25%), Positives = 165/400 (41%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPRIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEII--------G 210
             F +   +K +V    D++     +W +     S  +    ++ + L+ I        G
Sbjct: 148 PAFHN-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQG 206

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
            +  +    S+  +  D  S     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHGLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +   F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480


>M24667-1|AAA52148.1|  256|Homo sapiens steroid 11-beta-hydroxylase
           protein.
          Length = 256

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 53/184 (28%), Positives = 93/184 (50%), Gaps = 10/184 (5%)

Query: 298 SLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTL 357
           S++   L   +L    I    +++   ++D T +     L+ +ARN   Q  + +E  +L
Sbjct: 78  SIVAELLLNAELSPDAIKANCMELTAGSVDRTVFPLLMTLFELARNPNVQQPLRQE--SL 135

Query: 358 LPKKD-DEITADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVT 416
            P     E      ++   +R+++KE+LRL PV + + R +  D+VL+ Y IP GT++  
Sbjct: 136 APAASISEHPQKATTELPLLRAALKETLRLYPVGLILERVVSSDLVLQNYHIPAGTLVRV 195

Query: 417 QNMTSSRLPQFIRDPLTFKPERWM--RGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNI 474
              +  R P     P  + P+RW+  +GS +      F  +PFG G R C+ RRLAE ++
Sbjct: 196 FLYSLGRNPALFPRPERYNPQRWLDIKGSGR-----NFYHVPFGFGMRQCLGRRLAEADM 250

Query: 475 CIIL 478
            ++L
Sbjct: 251 LLLL 254


>BC028102-1|AAH28102.1|  509|Homo sapiens cytochrome P450, family 4,
           subfamily X, polypeptide 1 protein.
          Length = 509

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 92/362 (25%), Positives = 155/362 (42%), Gaps = 24/362 (6%)

Query: 142 GLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKND----F 197
           GL A +GP W++ R +    F     +K ++    +  K  ++  K +K+ S  D     
Sbjct: 124 GLAALDGPKWFQHRRLLTPGFHF-NILKAYIEVMAHSVKMMLD--KWEKICSTQDTSVEV 180

Query: 198 LTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKM 257
              +N ++L+II   AF++  N    S  DP +++   ++         +      ++K+
Sbjct: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240

Query: 258 FSTPLYKKLVNSQIYLEKISTDILIRKINLFESDDSKND-KSLLKTFLQQPQLDHKDIMG 316
            S   Y+    S++  +   T I  RK +L       N  K   + FL    L  KD  G
Sbjct: 241 -SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIV-LSAKDESG 298

Query: 317 MM---VDI-------LMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEIT 366
                +D+       L+A  DT A + S++LY +A N   Q+   EE+  +L      IT
Sbjct: 299 SSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSIT 357

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L + SY    IKE+ RL P    I R L K +    G ++P G  +V         P
Sbjct: 358 WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP 417

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              ++P  F P R+ + +      HP+  LPF  G R+CI +  A   + + +  ++  F
Sbjct: 418 AVWKNPKVFDPLRFSQENSDQR--HPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 486 EI 487
            +
Sbjct: 476 RV 477


>AY358537-1|AAQ88901.1|  509|Homo sapiens EFSW1929 protein.
          Length = 509

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 92/362 (25%), Positives = 155/362 (42%), Gaps = 24/362 (6%)

Query: 142 GLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKND----F 197
           GL A +GP W++ R +    F     +K ++    +  K  ++  K +K+ S  D     
Sbjct: 124 GLAALDGPKWFQHRRLLTPGFHF-NILKAYIEVMAHSVKMMLD--KWEKICSTQDTSVEV 180

Query: 198 LTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKM 257
              +N ++L+II   AF++  N    S  DP +++   ++         +      ++K+
Sbjct: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240

Query: 258 FSTPLYKKLVNSQIYLEKISTDILIRKINLFESDDSKND-KSLLKTFLQQPQLDHKDIMG 316
            S   Y+    S++  +   T I  RK +L       N  K   + FL    L  KD  G
Sbjct: 241 -SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIV-LSAKDESG 298

Query: 317 MM---VDI-------LMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEIT 366
                +D+       L+A  DT A + S++LY +A N   Q+   EE+  +L      IT
Sbjct: 299 SSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSIT 357

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L + SY    IKE+ RL P    I R L K +    G ++P G  +V         P
Sbjct: 358 WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP 417

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              ++P  F P R+ + +      HP+  LPF  G R+CI +  A   + + +  ++  F
Sbjct: 418 AVWKNPKVFDPLRFSQENSDQR--HPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 486 EI 487
            +
Sbjct: 476 RV 477


>AM040940-1|CAJ13826.1|  509|Homo sapiens cytochrome P450 protein.
          Length = 509

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 92/362 (25%), Positives = 155/362 (42%), Gaps = 24/362 (6%)

Query: 142 GLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKND----F 197
           GL A +GP W++ R +    F     +K ++    +  K  ++  K +K+ S  D     
Sbjct: 124 GLAALDGPKWFQHRRLLTPGFHF-NILKAYIEVMAHSVKMMLD--KWEKICSTQDTSVEV 180

Query: 198 LTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKM 257
              +N ++L+II   AF++  N    S  DP +++   ++         +      ++K+
Sbjct: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240

Query: 258 FSTPLYKKLVNSQIYLEKISTDILIRKINLFESDDSKND-KSLLKTFLQQPQLDHKDIMG 316
            S   Y+    S++  +   T I  RK +L       N  K   + FL    L  KD  G
Sbjct: 241 -SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIV-LSAKDESG 298

Query: 317 MM---VDI-------LMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEIT 366
                +D+       L+A  DT A + S++LY +A N   Q+   EE+  +L      IT
Sbjct: 299 SSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSIT 357

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L + SY    IKE+ RL P    I R L K +    G ++P G  +V         P
Sbjct: 358 WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP 417

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              ++P  F P R+ + +      HP+  LPF  G R+CI +  A   + + +  ++  F
Sbjct: 418 AVWKNPKVFDPLRFSQENSDQR--HPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 486 EI 487
            +
Sbjct: 476 RV 477


>AL450996-1|CAH71035.1|  509|Homo sapiens cytochrome P450, family 4,
           subfamily X, polypeptide 1 protein.
          Length = 509

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 92/362 (25%), Positives = 155/362 (42%), Gaps = 24/362 (6%)

Query: 142 GLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKND----F 197
           GL A +GP W++ R +    F     +K ++    +  K  ++  K +K+ S  D     
Sbjct: 124 GLAALDGPKWFQHRRLLTPGFHF-NILKAYIEVMAHSVKMMLD--KWEKICSTQDTSVEV 180

Query: 198 LTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKM 257
              +N ++L+II   AF++  N    S  DP +++   ++         +      ++K+
Sbjct: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240

Query: 258 FSTPLYKKLVNSQIYLEKISTDILIRKINLFESDDSKND-KSLLKTFLQQPQLDHKDIMG 316
            S   Y+    S++  +   T I  RK +L       N  K   + FL    L  KD  G
Sbjct: 241 -SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIV-LSAKDESG 298

Query: 317 MM---VDI-------LMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEIT 366
                +D+       L+A  DT A + S++LY +A N   Q+   EE+  +L      IT
Sbjct: 299 SSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSIT 357

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L + SY    IKE+ RL P    I R L K +    G ++P G  +V         P
Sbjct: 358 WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP 417

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              ++P  F P R+ + +      HP+  LPF  G R+CI +  A   + + +  ++  F
Sbjct: 418 AVWKNPKVFDPLRFSQENSDQR--HPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 486 EI 487
            +
Sbjct: 476 RV 477


>AK098065-1|BAC05226.1|  509|Homo sapiens protein ( Homo sapiens
           cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
           CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
          Length = 509

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 92/362 (25%), Positives = 155/362 (42%), Gaps = 24/362 (6%)

Query: 142 GLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKND----F 197
           GL A +GP W++ R +    F     +K ++    +  K  ++  K +K+ S  D     
Sbjct: 124 GLAALDGPKWFQHRRLLTPGFHF-NILKAYIEVMAHSVKMMLD--KWEKICSTQDTSVEV 180

Query: 198 LTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKM 257
              +N ++L+II   AF++  N    S  DP +++   ++         +      ++K+
Sbjct: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240

Query: 258 FSTPLYKKLVNSQIYLEKISTDILIRKINLFESDDSKND-KSLLKTFLQQPQLDHKDIMG 316
            S   Y+    S++  +   T I  RK +L       N  K   + FL    L  KD  G
Sbjct: 241 -SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIV-LSAKDESG 298

Query: 317 MM---VDI-------LMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEIT 366
                +D+       L+A  DT A + S++LY +A N   Q+   EE+  +L      IT
Sbjct: 299 SSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSIT 357

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L + SY    IKE+ RL P    I R L K +    G ++P G  +V         P
Sbjct: 358 WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP 417

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              ++P  F P R+ + +      HP+  LPF  G R+CI +  A   + + +  ++  F
Sbjct: 418 AVWKNPKVFDPLRFSQENSDQR--HPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 486 EI 487
            +
Sbjct: 476 RV 477


>AK091806-1|BAC03751.1|  444|Homo sapiens protein ( Homo sapiens
           cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
           CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
          Length = 444

 Score = 87.0 bits (206), Expect = 1e-16
 Identities = 92/362 (25%), Positives = 155/362 (42%), Gaps = 24/362 (6%)

Query: 142 GLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKND----F 197
           GL A +GP W++ R +    F     +K ++    +  K  ++  K +K+ S  D     
Sbjct: 59  GLAALDGPKWFQHRRLLTPGFHF-NILKAYIEVMAHSVKMMLD--KWEKICSTQDTSVEV 115

Query: 198 LTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKM 257
              +N ++L+II   AF++  N    S  DP +++   ++         +      ++K+
Sbjct: 116 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 175

Query: 258 FSTPLYKKLVNSQIYLEKISTDILIRKINLFESDDSKND-KSLLKTFLQQPQLDHKDIMG 316
            S   Y+    S++  +   T I  RK +L       N  K   + FL    L  KD  G
Sbjct: 176 -SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIV-LSAKDESG 233

Query: 317 MM---VDI-------LMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEIT 366
                +D+       L+A  DT A + S++LY +A N   Q+   EE+  +L      IT
Sbjct: 234 SSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSIT 292

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L + SY    IKE+ RL P    I R L K +    G ++P G  +V         P
Sbjct: 293 WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP 352

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              ++P  F P R+ + +      HP+  LPF  G R+CI +  A   + + +  ++  F
Sbjct: 353 AVWKNPKVFDPLRFSQENSDQR--HPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 410

Query: 486 EI 487
            +
Sbjct: 411 RV 412


>AK131355-1|BAD18508.1|  508|Homo sapiens protein ( Homo sapiens
           cDNA FLJ16384 fis, clone TLIVE2007607, weakly  similar
           to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
          Length = 508

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 91/362 (25%), Positives = 155/362 (42%), Gaps = 24/362 (6%)

Query: 142 GLLATNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKND----F 197
           GL A +GP W++ R +    F     +K ++    +  K  ++  K +K+ S  D     
Sbjct: 123 GLAALDGPKWFQHRRLLTPGFHF-NILKAYIEVMAHSVKMMLD--KWEKICSTQDTSVEV 179

Query: 198 LTFLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKM 257
              +N ++L+I+   AF++  N    S  DP +++   ++         +      ++K+
Sbjct: 180 YEHINSMSLDIVMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 239

Query: 258 FSTPLYKKLVNSQIYLEKISTDILIRKINLFESDDSKND-KSLLKTFLQQPQLDHKDIMG 316
            S   Y+    S++  +   T I  RK +L       N  K   + FL    L  KD  G
Sbjct: 240 -SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIV-LSAKDESG 297

Query: 317 MM---VDI-------LMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEIT 366
                +D+       L+A  DT A + S++LY +A N   Q+   EE+  +L      IT
Sbjct: 298 SSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGD-GSSIT 356

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L + SY    IKE+ RL P    I R L K +    G ++P G  +V         P
Sbjct: 357 WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP 416

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              ++P  F P R+ + +      HP+  LPF  G R+CI +  A   + + +  ++  F
Sbjct: 417 AVWKNPKVFDPLRFSQENSDQR--HPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 474

Query: 486 EI 487
            +
Sbjct: 475 RV 476


>AL135960-10|CAI19737.1|  519|Homo sapiens cytochrome P450, family
           4, subfamily A, polypeptide 22 protein.
          Length = 519

 Score = 86.2 bits (204), Expect = 2e-16
 Identities = 100/400 (25%), Positives = 165/400 (41%), Gaps = 28/400 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   Y+   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YKFLAPRIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEII--------G 210
             F +   +K +V    D++     +W +     S  +    ++ + L+ I        G
Sbjct: 148 PAFHN-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQG 206

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
            +  +    S+  +  D  S     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHGLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +   F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEI 487
             H F  LPF  G R+CI ++ A   + +     +  FE+
Sbjct: 445 --HAF--LPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480


>BC016853-1|AAH16853.1|  524|Homo sapiens CYP4F11 protein protein.
          Length = 524

 Score = 83.4 bits (197), Expect = 2e-15
 Identities = 57/182 (31%), Positives = 91/182 (50%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDD-EIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q++  +E+  LL  ++  EI 
Sbjct: 312 ELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L++  ++   IKESLRL+P    I R   +D VL  G  IPKG V +   +     P
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+ + + +  +  P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 TVWPDPEVYDPFRFNQENIKERS--PLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHF 489

Query: 486 EI 487
            I
Sbjct: 490 RI 491


>AY792513-1|AAV40834.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 3 protein.
          Length = 520

 Score = 83.4 bits (197), Expect = 2e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L++  ++   IKESLRL+P    + R   +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>AF236085-1|AAG15889.1|  524|Homo sapiens CYP4F11 protein.
          Length = 524

 Score = 83.4 bits (197), Expect = 2e-15
 Identities = 57/182 (31%), Positives = 91/182 (50%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDD-EIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q++  +E+  LL  ++  EI 
Sbjct: 312 ELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L++  ++   IKESLRL+P    I R   +D VL  G  IPKG V +   +     P
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+ + + +  +  P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 TVWPDPEVYDPFRFNQENIKERS--PLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHF 489

Query: 486 EI 487
            I
Sbjct: 490 RI 491


>AF054821-1|AAC08589.1|  520|Homo sapiens cytochrome P-450 protein.
          Length = 520

 Score = 83.4 bits (197), Expect = 2e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L++  ++   IKESLRL+P    + R   +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>D13705-1|BAA02864.1|  521|Homo sapiens fatty acid omega-hydroxylase
           protein.
          Length = 521

 Score = 83.0 bits (196), Expect = 2e-15
 Identities = 100/384 (26%), Positives = 162/384 (42%), Gaps = 29/384 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +    +
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLSHQHTRPK 266

Query: 271 -IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAID 327
            I L K  +  +  + KI      D   D  LL        L  KD+   +   +    D
Sbjct: 267 VIQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHD 325

Query: 328 TTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLN 387
           TTA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL 
Sbjct: 326 TTASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLY 384

Query: 388 PVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQY 446
           P   GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+
Sbjct: 385 PPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQH 444

Query: 447 ETIHPFLSLPFGHGPRSCIARRLA 470
              H F  LPF  G R+CI ++ A
Sbjct: 445 S--HAF--LPFSGGSRNCIGKQFA 464


>D12620-1|BAA02144.1|  520|Homo sapiens cytochrome P-450LTBV
           protein.
          Length = 520

 Score = 83.0 bits (196), Expect = 2e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L++  ++   IKESLRL+P    + R   +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLAF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>BC035959-1|AAH35959.1|  503|Homo sapiens cytochrome P450, family
           19, subfamily A, polypeptide 1 protein.
          Length = 503

 Score = 83.0 bits (196), Expect = 2e-15
 Identities = 85/352 (24%), Positives = 157/352 (44%), Gaps = 26/352 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F   +L E    S     I   F +   ++ +     +K+  +
Sbjct: 191 LRRVMLD-----TSNTLFLRISLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 238

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFL----QQPQLDHKDIMG 316
            LYKK   S   L+     ++  K     +++   +     T L    ++  L  +++  
Sbjct: 239 WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYV 376
            ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   +
Sbjct: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKVM 356

Query: 377 RSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
            + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F  
Sbjct: 357 ENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTL 415

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 416 ENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>AB002461-1|BAA25991.1|  520|Homo sapiens leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score = 83.0 bits (196), Expect = 2e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L++  ++   IKESLRL+P    + R   +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLAF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>AB002454-1|BAA25990.1|  520|Homo sapiens leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score = 83.0 bits (196), Expect = 2e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L++  ++   IKESLRL+P    + R   +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLAF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>M28420-1|AAA52141.1|  419|Homo sapiens cytochrome P-450 aromatase
           protein.
          Length = 419

 Score = 82.6 bits (195), Expect = 3e-15
 Identities = 89/353 (25%), Positives = 161/353 (45%), Gaps = 28/353 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 47  GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 106

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 107 LRRVMLD-----TSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 154

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSL-LKTFL----QQPQLDHKDIM 315
            LYKK   S   L K + ++LI +     S + K ++ +   T L    ++  L  +++ 
Sbjct: 155 WLYKKYEKSVKDL-KDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGDLTRENVN 213

Query: 316 GMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASY 375
             ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   
Sbjct: 214 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKV 271

Query: 376 VRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFK 435
           + + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F 
Sbjct: 272 MENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFT 330

Query: 436 PERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 331 LENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 377


>J04127-1|AAA52132.1|  503|Homo sapiens CYP19 protein.
          Length = 503

 Score = 82.6 bits (195), Expect = 3e-15
 Identities = 89/353 (25%), Positives = 161/353 (45%), Gaps = 28/353 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 191 LRRVMLD-----TSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 238

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSL-LKTFL----QQPQLDHKDIM 315
            LYKK   S   L K + ++LI +     S + K ++ +   T L    ++  L  +++ 
Sbjct: 239 WLYKKYEKSVKDL-KDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGDLTRENVN 297

Query: 316 GMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASY 375
             ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   
Sbjct: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKV 355

Query: 376 VRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFK 435
           + + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F 
Sbjct: 356 MENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFT 414

Query: 436 PERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 415 LENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>BC067440-1|AAH67440.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 2 protein.
          Length = 520

 Score = 82.6 bits (195), Expect = 3e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L+   ++   +KESLRL+P    I R + +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AMWPDPEVYDPFRF--DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>AB015306-1|BAA75823.1|  520|Homo sapiens Leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score = 82.6 bits (195), Expect = 3e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L+   ++   +KESLRL+P    I R + +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AMWPDPEVYDPFRF--DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for
           aromatase P-450. ).
          Length = 503

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 26/352 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 191 LRRVMLD-----TSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 238

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFL----QQPQLDHKDIMG 316
            LYKK   S   L+     ++  K     +++   +     T L    ++  L  +++  
Sbjct: 239 WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYV 376
            ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   +
Sbjct: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKVM 356

Query: 377 RSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
            + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F  
Sbjct: 357 ENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTL 415

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 416 ENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for
           aromatase (estrogen synthetase). ).
          Length = 503

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 26/352 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 191 LRRVMLD-----TSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 238

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFL----QQPQLDHKDIMG 316
            LYKK   S   L+     ++  K     +++   +     T L    ++  L  +++  
Sbjct: 239 WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYV 376
            ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   +
Sbjct: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKVM 356

Query: 377 RSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
            + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F  
Sbjct: 357 ENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTL 415

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 416 ENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase
           cytochrome P-450 gene, exon 10. ).
          Length = 503

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 26/352 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 191 LRRVMLD-----TSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 238

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFL----QQPQLDHKDIMG 316
            LYKK   S   L+     ++  K     +++   +     T L    ++  L  +++  
Sbjct: 239 WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYV 376
            ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   +
Sbjct: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKVM 356

Query: 377 RSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
            + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F  
Sbjct: 357 ENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTL 415

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 416 ENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>M22246-1|AAA35557.1|  503|Homo sapiens protein ( Human aromatase
           mRNA, complete cds. ).
          Length = 503

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 26/352 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 191 LRRVMLD-----TSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 238

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFL----QQPQLDHKDIMG 316
            LYKK   S   L+     ++  K     +++   +     T L    ++  L  +++  
Sbjct: 239 WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYV 376
            ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   +
Sbjct: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKVM 356

Query: 377 RSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
            + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F  
Sbjct: 357 ENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTL 415

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 416 ENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>M18856-1|AAA35556.1|  419|Homo sapiens protein ( Human aromatase
           (Aro1) mRNA, complete cds. ).
          Length = 419

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 26/352 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 47  GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 106

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 107 LRRVMLD-----TSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 154

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFL----QQPQLDHKDIMG 316
            LYKK   S   L+     ++  K     +++   +     T L    ++  L  +++  
Sbjct: 155 WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 214

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYV 376
            ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   +
Sbjct: 215 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKVM 272

Query: 377 RSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
            + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F  
Sbjct: 273 ENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTL 331

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 332 ENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 377


>D26480-1|BAA05490.1|  520|Homo sapiens leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L+   ++   +KESLRL+P    I R + +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>DQ118405-1|AAZ23558.1|  503|Homo sapiens cytochrome P450 subfamily
           19 subfamily A polypeptide 1 protein.
          Length = 503

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 26/352 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 191 LRRVMLD-----TSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 238

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFL----QQPQLDHKDIMG 316
            LYKK   S   L+     ++  K     +++   +     T L    ++  L  +++  
Sbjct: 239 WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYV 376
            ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   +
Sbjct: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKVM 356

Query: 377 RSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
            + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F  
Sbjct: 357 ENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTL 415

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 416 ENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>BC067439-1|AAH67439.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 2 protein.
          Length = 520

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L+   ++   +KESLRL+P    I R + +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>BC067437-1|AAH67437.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 2 protein.
          Length = 520

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L+   ++   +KESLRL+P    I R + +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>BC035350-1|AAH35350.1|  524|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 12 protein.
          Length = 524

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 4/179 (2%)

Query: 309 LDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEITA 367
           L  +DI       +    DTTA   S+VLY++AR+   Q+   +E+  LL  +D  EI  
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQ 426
           D L++  ++   +KESLRL+P +  I R   +DIVL  G  IPKG   +   +     P 
Sbjct: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              DP  + P R+   + +  +  P   +PF  GPR+CI +  A   + ++L  ++  F
Sbjct: 433 VWPDPEVYDPFRFDPENSKGRS--PLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489


>AY957953-1|AAX44046.1|  503|Homo sapiens cytochrome P450, family
           19, subfamily A, polypeptide 1 protein.
          Length = 503

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 26/352 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 191 LRRVMLD-----TSNTLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 238

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFL----QQPQLDHKDIMG 316
            LYKK   S   L+     ++  K     +++   +     T L    ++  L  +++  
Sbjct: 239 WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYV 376
            ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   +
Sbjct: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKVM 356

Query: 377 RSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
            + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F  
Sbjct: 357 ENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTL 415

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 416 ENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>AY358977-1|AAQ89336.1|  524|Homo sapiens CYP4F12 protein.
          Length = 524

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 4/179 (2%)

Query: 309 LDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEITA 367
           L  +DI       +    DTTA   S+VLY++AR+   Q+   +E+  LL  +D  EI  
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQ 426
           D L++  ++   +KESLRL+P +  I R   +DIVL  G  IPKG   +   +     P 
Sbjct: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              DP  + P R+   + +  +  P   +PF  GPR+CI +  A   + ++L  ++  F
Sbjct: 433 VWPDPEVYDPFRFDPENSKGRS--PLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489


>AY008841-1|AAG33247.1|  524|Homo sapiens cytochrome P450 isoform
           4F12 protein.
          Length = 524

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 4/179 (2%)

Query: 309 LDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEITA 367
           L  +DI       +    DTTA   S+VLY++AR+   Q+   +E+  LL  +D  EI  
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQ 426
           D L++  ++   +KESLRL+P +  I R   +DIVL  G  IPKG   +   +     P 
Sbjct: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              DP  + P R+   + +  +  P   +PF  GPR+CI +  A   + ++L  ++  F
Sbjct: 433 VWPDPEVYDPFRFDPENSKGRS--PLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489


>AF467894-1|AAL67578.1|  520|Homo sapiens cytochrome P450, subfamily
           IVF, polypeptide 2 protein.
          Length = 520

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L+   ++   +KESLRL+P    I R + +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>AC005336-1|AAC27730.1|  520|Homo sapiens CYP4F2 protein.
          Length = 520

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L+   ++   +KESLRL+P    I R + +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>AC004523-1|AAC11543.1|  458|Homo sapiens F22329_1 protein.
          Length = 458

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 4/179 (2%)

Query: 309 LDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEITA 367
           L  +DI       +    DTTA   S+VLY++AR+   Q+   +E+  LL  +D  EI  
Sbjct: 247 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 306

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQ 426
           D L++  ++   +KESLRL+P +  I R   +DIVL  G  IPKG   +   +     P 
Sbjct: 307 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 366

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              DP  + P R+   + +  +  P   +PF  GPR+CI +  A   + ++L  ++  F
Sbjct: 367 VWPDPEVYDPFRFDPENSKGRS--PLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 423


>AB035131-1|BAB18270.1|  524|Homo sapiens cytochrome P450 protein.
          Length = 524

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 4/179 (2%)

Query: 309 LDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEITA 367
           L  +DI       +    DTTA   S+VLY++AR+   Q+   +E+  LL  +D  EI  
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQ 426
           D L++  ++   +KESLRL+P +  I R   +DIVL  G  IPKG   +   +     P 
Sbjct: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              DP  + P R+   + +  +  P   +PF  GPR+CI +  A   + ++L  ++  F
Sbjct: 433 VWPDPEVYDPFRFDPENSKGRS--PLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489


>AB035130-1|BAB18269.1|  524|Homo sapiens cytochrome P450 protein.
          Length = 524

 Score = 82.2 bits (194), Expect = 4e-15
 Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 4/179 (2%)

Query: 309 LDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEITA 367
           L  +DI       +    DTTA   S+VLY++AR+   Q+   +E+  LL  +D  EI  
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQ 426
           D L++  ++   +KESLRL+P +  I R   +DIVL  G  IPKG   +   +     P 
Sbjct: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
              DP  + P R+   + +  +  P   +PF  GPR+CI +  A   + ++L  ++  F
Sbjct: 433 VWPDPEVYDPFRFDPENSKGRS--PLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489


>U02388-1|AAC50052.2|  520|Homo sapiens cytochrome P450 4F2 protein.
          Length = 520

 Score = 81.8 bits (193), Expect = 5e-15
 Identities = 54/182 (29%), Positives = 88/182 (48%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTTA   S+VLYH+A++   Q+   +E+  LL  ++  EI 
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASVLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLP 425
            D L+   ++   +KESLR++P    I R + +DIVL  G  IPKG + +     +   P
Sbjct: 372 WDDLAHLPFLTMCMKESLRVHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               DP  + P R+       +   P   +PF  GPR+CI +  A   + ++L   +  F
Sbjct: 432 AVWPDPEVYDPFRF--DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489

Query: 486 EI 487
            +
Sbjct: 490 RV 491


>BC107785-1|AAI07786.1|  503|Homo sapiens cytochrome P450, family
           19, subfamily A, polypeptide 1 protein.
          Length = 503

 Score = 81.8 bits (193), Expect = 5e-15
 Identities = 85/352 (24%), Positives = 156/352 (44%), Gaps = 26/352 (7%)

Query: 142 GLLATNGPDWWRL-RSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF 200
           G++  N P+ W+  R  F K  + P  V+      +++        +    S   D LT 
Sbjct: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190

Query: 201 LNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFST 260
           L R+ L+       N  F    L E    S     I   F +   ++ +     +K+  +
Sbjct: 191 LRRVMLD-----TSNMLFLRIPLDE----SAIVVKIQGYFDAWQALL-IKPDIFFKI--S 238

Query: 261 PLYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFL----QQPQLDHKDIMG 316
            LYKK   S   L+     ++  K     +++   +     T L    ++  L  +++  
Sbjct: 239 WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYV 376
            ++++L+AA DT + +  F+L+ IA++   ++ + +E+ T++ ++D +I  D + K   +
Sbjct: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI--DDIQKLKVM 356

Query: 377 RSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
            + I ES+R  PV   + R   +D V+ GY + KGT I+       RL +F   P  F  
Sbjct: 357 ENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTL 415

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E + +  P Y         PFG GPR C  + +A   +  IL+ L+R F ++
Sbjct: 416 ENFAKNVP-YRYFQ-----PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461


>U23942-1|AAB39951.1|  509|Homo sapiens lanosterol 14-demethylase
           cytochrome P450 protein.
          Length = 509

 Score = 81.4 bits (192), Expect = 7e-15
 Identities = 61/237 (25%), Positives = 108/237 (45%), Gaps = 10/237 (4%)

Query: 279 DILIRKINLFESDDSKNDKSLLKTFLQQPQLDHK-----DIMGMMVDILMAAIDTTAYTT 333
           DI  + I        K D  +L+T L     D +     ++ GM++ +L+A   T++ T+
Sbjct: 268 DIFYKAIQKRRQSQEKID-DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTS 326

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           +++ + +AR+K  Q + + E  T+  +    +T D L   + +   IKE+LRL P  + +
Sbjct: 327 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM 386

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +    + GY+IP G  +      + RL     + L F P+R+++ +P   +   F 
Sbjct: 387 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNP--ASGEKFA 444

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEELGV--KTLLINKPNKPV 508
            +PFG G   CI    A   I  I   ++R +E             T +I+ P  PV
Sbjct: 445 YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV 501


>D55653-1|BAA09512.1|  509|Homo sapiens lanosterol 14-demethylase
           protein.
          Length = 509

 Score = 81.4 bits (192), Expect = 7e-15
 Identities = 61/237 (25%), Positives = 108/237 (45%), Gaps = 10/237 (4%)

Query: 279 DILIRKINLFESDDSKNDKSLLKTFLQQPQLDHK-----DIMGMMVDILMAAIDTTAYTT 333
           DI  + I        K D  +L+T L     D +     ++ GM++ +L+A   T++ T+
Sbjct: 268 DIFYKAIQKRRQSQEKID-DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTS 326

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           +++ + +AR+K  Q + + E  T+  +    +T D L   + +   IKE+LRL P  + +
Sbjct: 327 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM 386

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +    + GY+IP G  +      + RL     + L F P+R+++ +P   +   F 
Sbjct: 387 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNP--ASGEKFA 444

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEELGV--KTLLINKPNKPV 508
            +PFG G   CI    A   I  I   ++R +E             T +I+ P  PV
Sbjct: 445 YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV 501


>BC032322-1|AAH32322.1|  509|Homo sapiens cytochrome P450, family
           51, subfamily A, polypeptide 1 protein.
          Length = 509

 Score = 81.4 bits (192), Expect = 7e-15
 Identities = 61/237 (25%), Positives = 108/237 (45%), Gaps = 10/237 (4%)

Query: 279 DILIRKINLFESDDSKNDKSLLKTFLQQPQLDHK-----DIMGMMVDILMAAIDTTAYTT 333
           DI  + I        K D  +L+T L     D +     ++ GM++ +L+A   T++ T+
Sbjct: 268 DIFYKAIQKRRQSQEKID-DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTS 326

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           +++ + +AR+K  Q + + E  T+  +    +T D L   + +   IKE+LRL P  + +
Sbjct: 327 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPVMIM 386

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +    + GY+IP G  +      + RL     + L F P+R+++ +P   +   F 
Sbjct: 387 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNP--ASGEKFA 444

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEELGV--KTLLINKPNKPV 508
            +PFG G   CI    A   I  I   ++R +E             T +I+ P  PV
Sbjct: 445 YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV 501


>AF233623-1|AAF99277.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.4 bits (192), Expect = 7e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPK 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AC000120-2|AAB46356.1|  509|Homo sapiens unknown protein.
          Length = 509

 Score = 81.4 bits (192), Expect = 7e-15
 Identities = 61/237 (25%), Positives = 108/237 (45%), Gaps = 10/237 (4%)

Query: 279 DILIRKINLFESDDSKNDKSLLKTFLQQPQLDHK-----DIMGMMVDILMAAIDTTAYTT 333
           DI  + I        K D  +L+T L     D +     ++ GM++ +L+A   T++ T+
Sbjct: 268 DIFYKAIQKRRQSQEKID-DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTS 326

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           +++ + +AR+K  Q + + E  T+  +    +T D L   + +   IKE+LRL P  + +
Sbjct: 327 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM 386

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +    + GY+IP G  +      + RL     + L F P+R+++ +P   +   F 
Sbjct: 387 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNP--ASGEKFA 444

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEELGV--KTLLINKPNKPV 508
            +PFG G   CI    A   I  I   ++R +E             T +I+ P  PV
Sbjct: 445 YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV 501


>M80647-1|AAA60618.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>BC041157-1|AAH41157.1|  534|Homo sapiens thromboxane A synthase 1
           (platelet, cytochrome P450, family 5, subfamily A)
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>BC014117-1|AAH14117.1|  466|Homo sapiens TBXAS1 protein protein.
          Length = 466

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 263 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 322

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 323 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 382

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 383 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 436


>AK223466-1|BAD97186.1|  534|Homo sapiens thromboxane A synthase 1
           (platelet, cytochrome P450, family 5, subfamily A) iso
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF233625-1|AAF99279.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--QPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF233622-1|AAF99276.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAEDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF233621-1|AAF99275.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYVLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF233620-1|AAF99274.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF233619-1|AAF99273.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF233618-1|AAF99272.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF233617-1|AAF99271.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF233616-1|AAF99270.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF233615-1|AAF99269.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>AF133298-1|AAD49566.1|  520|Homo sapiens cytochrome P450 protein.
          Length = 520

 Score = 81.0 bits (191), Expect = 9e-15
 Identities = 58/194 (29%), Positives = 90/194 (46%), Gaps = 4/194 (2%)

Query: 296 DKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELH 355
           D  LL       +L  +DI       +    DTTA   S+VLY++AR+   Q+   +E+ 
Sbjct: 300 DVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQ 359

Query: 356 TLLPKKD-DEITADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVL-KGYSIPKGTV 413
            LL  ++  EI  D L++  ++   +KESLRL+P      R   +D+VL     IPKG V
Sbjct: 360 ELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNV 419

Query: 414 IVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQN 473
                      P    DP  + P R+   + Q  +  P   +PF  GPR+CI ++ A   
Sbjct: 420 CNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRS--PMAFIPFSAGPRNCIGQKFAMAE 477

Query: 474 ICIILMRLIREFEI 487
           + ++L   +  F I
Sbjct: 478 MKVVLALTLLRFRI 491


>U51692-1|AAC50951.1|  503|Homo sapiens lanosterol 14-alpha
           demethylase protein.
          Length = 503

 Score = 79.8 bits (188), Expect = 2e-14
 Identities = 60/237 (25%), Positives = 108/237 (45%), Gaps = 10/237 (4%)

Query: 279 DILIRKINLFESDDSKNDKSLLKTFLQQPQLDHK-----DIMGMMVDILMAAIDTTAYTT 333
           DI  + I        K D  +L+T L     D +     ++ GM++ +L+A   T++ T+
Sbjct: 262 DIFYKAIQKRTQSQEKID-DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTS 320

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
           +++ + +AR+K  Q + + E  T+  +    +T D L   + +   I+E+LRL P  + +
Sbjct: 321 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIRETLRLRPPIMIM 380

Query: 394 GRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFL 453
            R  +    + GY+IP G  +      + RL     + L F P+R+++ +P   +   F 
Sbjct: 381 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNP--ASGEKFA 438

Query: 454 SLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEELGV--KTLLINKPNKPV 508
            +PFG G   CI    A   I  I   ++R +E             T +I+ P  PV
Sbjct: 439 YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV 495


>D34625-1|BAA07011.1|  533|Homo sapiens thromboxane synthase
           protein.
          Length = 533

 Score = 79.0 bits (186), Expect = 4e-14
 Identities = 50/176 (28%), Positives = 77/176 (43%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 330 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 389

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 390 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 449

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           TF PER+   + Q     PF  LPFG GPRSC+   L    + + L+ ++ +F  Q
Sbjct: 450 TFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVHLGLLEVKLTLLHVLHKFRFQ 503


>AY358631-1|AAQ88994.1|  505|Homo sapiens EPSW3060 protein.
          Length = 505

 Score = 79.0 bits (186), Expect = 4e-14
 Identities = 52/159 (32%), Positives = 73/159 (45%), Gaps = 4/159 (2%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           D+   +   + A  DTT+   S++LY +A+    Q    +E+  LL      IT + LS+
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD-GSSITWEHLSQ 361

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLPQFIRDP 431
             Y    IKE LRL    + I R L K I    G S+P G  +          P F  DP
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421

Query: 432 LTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLA 470
             F P R+ R +   E IHP+  +PF  G R+CI +  A
Sbjct: 422 QVFNPLRFSRENS--EKIHPYAFIPFSAGLRNCIGQHFA 458


>AY262056-1|AAO89257.1|  505|Homo sapiens cytochrome P450 protein.
          Length = 505

 Score = 79.0 bits (186), Expect = 4e-14
 Identities = 52/159 (32%), Positives = 73/159 (45%), Gaps = 4/159 (2%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           D+   +   + A  DTT+   S++LY +A+    Q    +E+  LL      IT + LS+
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD-GSSITWEHLSQ 361

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLPQFIRDP 431
             Y    IKE LRL    + I R L K I    G S+P G  +          P F  DP
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421

Query: 432 LTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLA 470
             F P R+ R +   E IHP+  +PF  G R+CI +  A
Sbjct: 422 QVFNPLRFSRENS--EKIHPYAFIPFSAGLRNCIGQHFA 458


>AL450996-2|CAH71036.1|  505|Homo sapiens cytochrome P450, family 4,
           subfamily Z, polypeptide 1 protein.
          Length = 505

 Score = 79.0 bits (186), Expect = 4e-14
 Identities = 52/159 (32%), Positives = 73/159 (45%), Gaps = 4/159 (2%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           D+   +   + A  DTT+   S++LY +A+    Q    +E+  LL      IT + LS+
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD-GSSITWEHLSQ 361

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLPQFIRDP 431
             Y    IKE LRL    + I R L K I    G S+P G  +          P F  DP
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421

Query: 432 LTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLA 470
             F P R+ R +   E IHP+  +PF  G R+CI +  A
Sbjct: 422 QVFNPLRFSRENS--EKIHPYAFIPFSAGLRNCIGQHFA 458


>AL135960-6|CAI19734.1|  505|Homo sapiens cytochrome P450, family 4,
           subfamily Z, polypeptide 1 protein.
          Length = 505

 Score = 79.0 bits (186), Expect = 4e-14
 Identities = 52/159 (32%), Positives = 73/159 (45%), Gaps = 4/159 (2%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           D+   +   + A  DTT+   S++LY +A+    Q    +E+  LL      IT + LS+
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD-GSSITWEHLSQ 361

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLPQFIRDP 431
             Y    IKE LRL    + I R L K I    G S+P G  +          P F  DP
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421

Query: 432 LTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLA 470
             F P R+ R +   E IHP+  +PF  G R+CI +  A
Sbjct: 422 QVFNPLRFSRENS--EKIHPYAFIPFSAGLRNCIGQHFA 458


>AK090886-1|BAC03539.1|  337|Homo sapiens protein ( Homo sapiens
           cDNA FLJ33567 fis, clone BRAMY2010272, highly similar to
           Homo sapiens cholesterol 24-hydroxylase mRNA. ).
          Length = 337

 Score = 79.0 bits (186), Expect = 4e-14
 Identities = 53/207 (25%), Positives = 101/207 (48%), Gaps = 16/207 (7%)

Query: 310 DHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADV 369
           D + ++   V   +A  +T+A   +F +  ++R       +  E+  ++  K   +  + 
Sbjct: 135 DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKR-YLDFED 193

Query: 370 LSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIR 429
           L +  Y+   +KESLRL P + G  R L+++ ++ G+S    T ++       R+  +  
Sbjct: 194 LGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGFS----TYVM------GRMDTYFE 243

Query: 430 DPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQW 489
           DPLTF P+R+  G+P+      F   PF  G RSCI ++ A+  + +++ +L++  E + 
Sbjct: 244 DPLTFNPDRFGPGAPKPR----FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRL 299

Query: 490 A-GEELGVKTLLINKPNKPVSLNFIPR 515
             G+  G++     KP  PV     PR
Sbjct: 300 VPGQRFGLQEQATLKPLDPVLCTLRPR 326


>AF233624-1|AAF99278.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score = 79.0 bits (186), Expect = 4e-14
 Identities = 50/176 (28%), Positives = 77/176 (43%), Gaps = 2/176 (1%)

Query: 313 DIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSK 372
           +I+G     L+A  +    T SF  Y +A N  CQ+++  E+     K        +   
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   I E+LR+ P +    R   +D  + G  IP G V+          P+    P 
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            F PER+   + Q     PF  LPFG GPRSC+  RL    + + L+ ++ +F  Q
Sbjct: 451 NFNPERFTAEARQQH--RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQ 504


>BC041158-1|AAH41158.1|  455|Homo sapiens CYP4A11 protein protein.
          Length = 455

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 97/375 (25%), Positives = 156/375 (41%), Gaps = 28/375 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPR 462
             H F  LPF  G R
Sbjct: 445 --HAF--LPFSGGSR 455


>AL731892-4|CAH72779.1|  455|Homo sapiens cytochrome P450, family 4,
           subfamily A, polypeptide 11 protein.
          Length = 455

 Score = 78.6 bits (185), Expect = 5e-14
 Identities = 97/375 (25%), Positives = 156/375 (41%), Gaps = 28/375 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   YR   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YRFLAPWIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEIIGVVAFNERF 218
             F     +K +V    D++     +W +     S  +    ++ + L+ I   AF+ + 
Sbjct: 148 PAFHY-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQG 206

Query: 219 N--------SFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
           +        S+  +  D  +     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H+LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHSLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +P  F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPR 462
             H F  LPF  G R
Sbjct: 445 --HAF--LPFSGGSR 455


>BC100982-1|AAI00983.1|  280|Homo sapiens CYP3A43 protein protein.
          Length = 280

 Score = 77.8 bits (183), Expect = 9e-14
 Identities = 47/152 (30%), Positives = 77/152 (50%), Gaps = 8/152 (5%)

Query: 287 LFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRC 346
           + +S +SK  KS          L   +++   + I+ AA DTT+ T  F++Y +A +   
Sbjct: 135 IIDSQNSKETKS-------HKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDV 187

Query: 347 QDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGY 406
           Q ++ EE+  +LP K   +T D L +  Y+   + E+LRL PV   + R  +KDI + G 
Sbjct: 188 QQKLQEEIDAVLPNKAP-VTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGV 246

Query: 407 SIPKGTVIVTQNMTSSRLPQFIRDPLTFKPER 438
            IPKG  ++         P++  +P  F PER
Sbjct: 247 FIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 278


>BC096286-1|AAH96286.1|  437|Homo sapiens cytochrome P450, family
           11, subfamily B, polypeptide 1 protein.
          Length = 437

 Score = 77.4 bits (182), Expect = 1e-13
 Identities = 67/320 (20%), Positives = 132/320 (41%), Gaps = 10/320 (3%)

Query: 99  LVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIF 158
           +V V  P+D+E + + D  +P R S      YR ++ +     G+   NGP+W   R   
Sbjct: 88  MVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKC---GVFLLNGPEWRFNRLRL 144

Query: 159 QKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTF-----LNRLNLEIIGVVA 213
                SP +V+  +   D +A++F + +K+  + +    LT      +    +E   +  
Sbjct: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204

Query: 214 FNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYL 273
           F ER      S           +   F S   +M + +  L +  S  ++K+   +   +
Sbjct: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWTSPKVWKEHFEAWDCI 263

Query: 274 EKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTT 333
            +   + + +          +   S++   L   +L    I    +++   ++DTT +  
Sbjct: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 323

Query: 334 SFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVSIGI 393
              L+ +ARN   Q  + +E          E      ++   +R+++KE+LRL PV + +
Sbjct: 324 LMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382

Query: 394 GRWLQKDIVLKGYSIPKGTV 413
            R    D+VL+ Y IP G +
Sbjct: 383 ERVASSDLVLQNYHIPAGVL 402


>AL358613-3|CAH72804.1|  428|Homo sapiens cytochrome P450, family
           26, subfamily A, polypeptide 1 protein.
          Length = 428

 Score = 76.6 bits (180), Expect = 2e-13
 Identities = 60/236 (25%), Positives = 109/236 (46%), Gaps = 11/236 (4%)

Query: 262 LYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQP-----QLDHKDIMG 316
           LY+ +    +   +I  +I  +   L  S+  +  K  L+  ++       +LD + +  
Sbjct: 164 LYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQ 223

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHT--LLPK--KDDEITADVLSK 372
              ++L    +TTA   + ++ ++        ++ EEL +  LL K  +D+++  ++L +
Sbjct: 224 SSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQ 283

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   IKE+LRLNP   G  R   K   L GY IPKG  ++     +  + +   +  
Sbjct: 284 LKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKE 343

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            F P+R+M   P  E    F  +PFG G RSC+ +  A+  + I  + L R  + Q
Sbjct: 344 EFNPDRFM--LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQ 397


>AL358613-2|CAH72803.1|  497|Homo sapiens cytochrome P450, family
           26, subfamily A, polypeptide 1 protein.
          Length = 497

 Score = 76.6 bits (180), Expect = 2e-13
 Identities = 60/236 (25%), Positives = 109/236 (46%), Gaps = 11/236 (4%)

Query: 262 LYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQP-----QLDHKDIMG 316
           LY+ +    +   +I  +I  +   L  S+  +  K  L+  ++       +LD + +  
Sbjct: 233 LYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQ 292

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHT--LLPK--KDDEITADVLSK 372
              ++L    +TTA   + ++ ++        ++ EEL +  LL K  +D+++  ++L +
Sbjct: 293 SSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQ 352

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   IKE+LRLNP   G  R   K   L GY IPKG  ++     +  + +   +  
Sbjct: 353 LKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKE 412

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            F P+R+M   P  E    F  +PFG G RSC+ +  A+  + I  + L R  + Q
Sbjct: 413 EFNPDRFM--LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQ 466


>AF005418-1|AAB88881.1|  497|Homo sapiens retinoic acid hydroxylase
           protein.
          Length = 497

 Score = 76.6 bits (180), Expect = 2e-13
 Identities = 60/236 (25%), Positives = 109/236 (46%), Gaps = 11/236 (4%)

Query: 262 LYKKLVNSQIYLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQP-----QLDHKDIMG 316
           LY+ +    +   +I  +I  +   L  S+  +  K  L+  ++       +LD + +  
Sbjct: 233 LYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQ 292

Query: 317 MMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHT--LLPK--KDDEITADVLSK 372
              ++L    +TTA   + ++ ++        ++ EEL +  LL K  +D+++  ++L +
Sbjct: 293 SSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQ 352

Query: 373 ASYVRSSIKESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPL 432
             Y+   IKE+LRLNP   G  R   K   L GY IPKG  ++     +  + +   +  
Sbjct: 353 LKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKE 412

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
            F P+R+M   P  E    F  +PFG G RSC+ +  A+  + I  + L R  + Q
Sbjct: 413 EFNPDRFM--LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQ 466


>BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score = 75.4 bits (177), Expect = 5e-13
 Identities = 55/207 (26%), Positives = 99/207 (47%), Gaps = 12/207 (5%)

Query: 287 LFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRC 346
           L E D  KND S   TF ++      +++  + ++++A  +TT     + +  +A     
Sbjct: 281 LDEMDQGKNDPS--STFSKE------NLIFSVGELIIAGTETTTNVLRWAILFMALYPNI 332

Query: 347 QDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRL-NPVSIGIGRWLQKDIVLKG 405
           Q ++ +E+  L+   + + + D   K  Y  + + E LR  N V +GI     +D V++G
Sbjct: 333 QGQVQKEID-LIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG 391

Query: 406 YSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCI 465
           YSIPKGT ++T   +     ++ RDP  F PER++  S  +        +PF  G R C+
Sbjct: 392 YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL--VPFSLGRRHCL 449

Query: 466 ARRLAEQNICIILMRLIREFEIQWAGE 492
              LA   + +    L++ F + +  E
Sbjct: 450 GEHLARMEMFLFFTALLQRFHLHFPHE 476


>BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score = 75.4 bits (177), Expect = 5e-13
 Identities = 55/207 (26%), Positives = 99/207 (47%), Gaps = 12/207 (5%)

Query: 287 LFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRC 346
           L E D  KND S   TF ++      +++  + ++++A  +TT     + +  +A     
Sbjct: 281 LDEMDQGKNDPS--STFSKE------NLIFSVGELIIAGTETTTNVLRWAILFMALYPNI 332

Query: 347 QDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRL-NPVSIGIGRWLQKDIVLKG 405
           Q ++ +E+  L+   + + + D   K  Y  + + E LR  N V +GI     +D V++G
Sbjct: 333 QGQVQKEID-LIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG 391

Query: 406 YSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCI 465
           YSIPKGT ++T   +     ++ RDP  F PER++  S  +        +PF  G R C+
Sbjct: 392 YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL--VPFSLGRRHCL 449

Query: 466 ARRLAEQNICIILMRLIREFEIQWAGE 492
              LA   + +    L++ F + +  E
Sbjct: 450 GEHLARMEMFLFFTALLQRFHLHFPHE 476


>AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1
           protein.
          Length = 501

 Score = 75.4 bits (177), Expect = 5e-13
 Identities = 55/207 (26%), Positives = 99/207 (47%), Gaps = 12/207 (5%)

Query: 287 LFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRC 346
           L E D  KND S   TF ++      +++  + ++++A  +TT     + +  +A     
Sbjct: 281 LDEMDQGKNDPS--STFSKE------NLIFSVGELIIAGTETTTNVLRWAILFMALYPNI 332

Query: 347 QDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRL-NPVSIGIGRWLQKDIVLKG 405
           Q ++ +E+  L+   + + + D   K  Y  + + E LR  N V +GI     +D V++G
Sbjct: 333 QGQVQKEID-LIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG 391

Query: 406 YSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCI 465
           YSIPKGT ++T   +     ++ RDP  F PER++  S  +        +PF  G R C+
Sbjct: 392 YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL--VPFSLGRRHCL 449

Query: 466 ARRLAEQNICIILMRLIREFEIQWAGE 492
              LA   + +    L++ F + +  E
Sbjct: 450 GEHLARMEMFLFFTALLQRFHLHFPHE 476


>AL135960-11|CAI19738.1|  455|Homo sapiens cytochrome P450, family
           4, subfamily A, polypeptide 22 protein.
          Length = 455

 Score = 75.4 bits (177), Expect = 5e-13
 Identities = 95/375 (25%), Positives = 153/375 (40%), Gaps = 28/375 (7%)

Query: 100 VHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGLLATNGPDWWRLRSIFQ 159
           V +YDPD ++ +  +       +SH +   Y+   P +    GLL  NG  W++ R +  
Sbjct: 97  VQLYDPDYMKVILGRSDP----KSHGS---YKFLAPRIGY--GLLLLNGQTWFQHRRMLT 147

Query: 160 KNFTSPQSVKTHVS-DTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLEII--------G 210
             F +   +K +V    D++     +W +     S  +    ++ + L+ I        G
Sbjct: 148 PAFHN-DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQG 206

Query: 211 VVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQ 270
            +  +    S+  +  D  S     +  AF  N  +  L     W   +  L  +  +  
Sbjct: 207 SIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQV 266

Query: 271 IYLEK--ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT 328
           I L K  +  +  + KI      D   D  LL        L  KD+   +   +    DT
Sbjct: 267 IQLRKAQLQKEGELEKIKRKRHLDFL-DILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325

Query: 329 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNP 388
           TA   S++LY +A + + Q+   EE+H LL      IT + L +  Y    IKE+LRL P
Sbjct: 326 TASGISWILYALATHPKHQERCREEIHGLL-GDGASITWNHLDQMPYTTMCIKEALRLYP 384

Query: 389 VSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYE 447
              GIGR L   +    G S+PKG +++         P+   +   F P R+  GS Q+ 
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHS 444

Query: 448 TIHPFLSLPFGHGPR 462
             H F  LPF  G R
Sbjct: 445 --HAF--LPFSGGSR 455


>BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family 2,
           subfamily U, polypeptide 1 protein.
          Length = 544

 Score = 73.3 bits (172), Expect = 2e-12
 Identities = 47/177 (26%), Positives = 89/177 (50%), Gaps = 4/177 (2%)

Query: 310 DHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADV 369
           D + +  ++ D+ +A  DTT  +  + L +++ N   Q+++ EE+  ++         D 
Sbjct: 338 DEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK 397

Query: 370 LSKASYVRSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFI 428
            ++  Y  ++I E  RL  V  + I     ++ VL+GY+IPKGT+I+    +  R P   
Sbjct: 398 -AQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456

Query: 429 RDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
             P  F P R++    Q + I     +PFG G R C+  +LA+  + ++ + L++ F
Sbjct: 457 EKPEDFYPNRFL--DDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511


>AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.
          Length = 544

 Score = 73.3 bits (172), Expect = 2e-12
 Identities = 47/177 (26%), Positives = 89/177 (50%), Gaps = 4/177 (2%)

Query: 310 DHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADV 369
           D + +  ++ D+ +A  DTT  +  + L +++ N   Q+++ EE+  ++         D 
Sbjct: 338 DEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK 397

Query: 370 LSKASYVRSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFI 428
            ++  Y  ++I E  RL  V  + I     ++ VL+GY+IPKGT+I+    +  R P   
Sbjct: 398 -AQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456

Query: 429 RDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
             P  F P R++    Q + I     +PFG G R C+  +LA+  + ++ + L++ F
Sbjct: 457 EKPEDFYPNRFL--DDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511


>M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 4/219 (1%)

Query: 272 YLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAY 331
           Y EK  +D +   ++        +D            L    I+  + DI  A ++TT  
Sbjct: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 332 TTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS- 390
              + L  +  N + + +++EE+   +        +D  ++   + ++I+E LRL PV+ 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-RNRLLLLEATIREVLRLRPVAP 368

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + I      D  +  +++ KGT ++          +    P  F PER++  +   + I 
Sbjct: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT-QLIS 427

Query: 451 PFLS-LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           P +S LPFG GPRSCI   LA Q + +I+  L++ F+++
Sbjct: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 4/219 (1%)

Query: 272 YLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAY 331
           Y EK  +D +   ++        +D            L    I+  + DI  A ++TT  
Sbjct: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 332 TTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS- 390
              + L  +  N + + +++EE+   +        +D  ++   + ++I+E LRL PV+ 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-RNRLLLLEATIREVLRLRPVAP 368

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + I      D  +  +++ KGT ++          +    P  F PER++  +   + I 
Sbjct: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT-QLIS 427

Query: 451 PFLS-LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           P +S LPFG GPRSCI   LA Q + +I+  L++ F+++
Sbjct: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 4/219 (1%)

Query: 272 YLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAY 331
           Y EK  +D +   ++        +D            L    I+  + DI  A ++TT  
Sbjct: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 332 TTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS- 390
              + L  +  N + + +++EE+   +        +D  ++   + ++I+E LRL PV+ 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-RNRLLLLEATIREVLRLRPVAP 368

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + I      D  +  +++ KGT ++          +    P  F PER++  +   + I 
Sbjct: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT-QLIS 427

Query: 451 PFLS-LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           P +S LPFG GPRSCI   LA Q + +I+  L++ F+++
Sbjct: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 4/219 (1%)

Query: 272 YLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAY 331
           Y EK  +D +   ++        +D            L    I+  + DI  A ++TT  
Sbjct: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 332 TTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS- 390
              + L  +  N + + +++EE+   +        +D  ++   + ++I+E LRL PV+ 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-RNRLLLLEATIREVLRLRPVAP 368

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + I      D  +  +++ KGT ++          +    P  F PER++  +   + I 
Sbjct: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT-QLIS 427

Query: 451 PFLS-LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           P +S LPFG GPRSCI   LA Q + +I+  L++ F+++
Sbjct: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 4/219 (1%)

Query: 272 YLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAY 331
           Y EK  +D +   ++        +D            L    I+  + DI  A ++TT  
Sbjct: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 332 TTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS- 390
              + L  +  N + + +++EE+   +        +D  ++   + ++I+E LRL PV+ 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-RNRLLLLEATIREVLRLRPVAP 368

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + I      D  +  +++ KGT ++          +    P  F PER++  +   + I 
Sbjct: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT-QLIS 427

Query: 451 PFLS-LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           P +S LPFG GPRSCI   LA Q + +I+  L++ F+++
Sbjct: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 4/219 (1%)

Query: 272 YLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAY 331
           Y EK  +D +   ++        +D            L    I+  + DI  A ++TT  
Sbjct: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 332 TTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS- 390
              + L  +  N + + +++EE+   +        +D  ++   + ++I+E LRL PV+ 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-RNRLLLLEATIREVLRLRPVAP 368

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + I      D  +  +++ KGT ++          +    P  F PER++  +   + I 
Sbjct: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT-QLIS 427

Query: 451 PFLS-LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           P +S LPFG GPRSCI   LA Q + +I+  L++ F+++
Sbjct: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 4/219 (1%)

Query: 272 YLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAY 331
           Y EK  +D +   ++        +D            L    I+  + DI  A ++TT  
Sbjct: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 332 TTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS- 390
              + L  +  N + + +++EE+   +        +D  ++   + ++I+E LRL PV+ 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-RNRLLLLEATIREVLRLRPVAP 368

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + I      D  +  +++ KGT ++          +    P  F PER++  +   + I 
Sbjct: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT-QLIS 427

Query: 451 PFLS-LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           P +S LPFG GPRSCI   LA Q + +I+  L++ F+++
Sbjct: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 4/219 (1%)

Query: 272 YLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAY 331
           Y EK  +D +   ++        +D            L    I+  + DI  A ++TT  
Sbjct: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 332 TTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS- 390
              + L  +  N + + +++EE+   +        +D  ++   + ++I+E LRL PV+ 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-RNRLLLLEATIREVLRLRPVAP 368

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + I      D  +  +++ KGT ++          +    P  F PER++  +   + I 
Sbjct: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT-QLIS 427

Query: 451 PFLS-LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           P +S LPFG GPRSCI   LA Q + +I+  L++ F+++
Sbjct: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 53/219 (24%), Positives = 100/219 (45%), Gaps = 4/219 (1%)

Query: 272 YLEKISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDTTAY 331
           Y EK  +D +   ++        +D            L    I+  + DI  A ++TT  
Sbjct: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 332 TTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRLNPVS- 390
              + L  +  N + + +++EE+   +        +D  ++   + ++I+E LRL PV+ 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-RNRLLLLEATIREVLRLRPVAP 368

Query: 391 IGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIH 450
           + I      D  +  +++ KGT ++          +    P  F PER++  +   + I 
Sbjct: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT-QLIS 427

Query: 451 PFLS-LPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           P +S LPFG GPRSCI   LA Q + +I+  L++ F+++
Sbjct: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>X71480-1|CAA50586.1|  141|Homo sapiens cytochrome P450 protein.
          Length = 141

 Score = 71.7 bits (168), Expect = 6e-12
 Identities = 50/139 (35%), Positives = 69/139 (49%), Gaps = 6/139 (4%)

Query: 327 DTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKESLRL 386
           DTTA   S++LY +A + + Q+   EE+H LL      IT + L +  Y    IKE+LRL
Sbjct: 8   DTTASGISWILYALATHPKHQERCREEIHGLL-GDGASITWNHLDQMPYTTMCIKEALRL 66

Query: 387 NPVSIGIGRWLQKDIVL-KGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQ 445
            P   GI R L   +    G S+PKG  ++         P+   +P  F P R+  GS Q
Sbjct: 67  YPPVPGISRELSTPVTFPDGRSLPKGITVMLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQ 126

Query: 446 YETIHPFLSLPFGHGPRSC 464
           +   H F  LPF  G R+C
Sbjct: 127 HS--HAF--LPFSGGSRNC 141


>BC093896-1|AAH93896.1|  531|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 2 homolog protein.
          Length = 531

 Score = 71.7 bits (168), Expect = 6e-12
 Identities = 47/182 (25%), Positives = 87/182 (47%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTT+   S++L+++A+    Q++  EE+  ++  ++ +E+ 
Sbjct: 319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELE 378

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L++  +    IKESLR  P    + R   +DI L  G  IPKG + +     +   P
Sbjct: 379 WDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               D   + P R+   +PQ  +  P   +PF  GPR+CI +  A   + +++   +  F
Sbjct: 439 TVWPDSKVYNPYRFDPDNPQQRS--PLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRF 496

Query: 486 EI 487
            +
Sbjct: 497 RL 498


>BC093894-1|AAH93894.1|  531|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 2 homolog protein.
          Length = 531

 Score = 71.7 bits (168), Expect = 6e-12
 Identities = 47/182 (25%), Positives = 87/182 (47%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTT+   S++L+++A+    Q++  EE+  ++  ++ +E+ 
Sbjct: 319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELE 378

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L++  +    IKESLR  P    + R   +DI L  G  IPKG + +     +   P
Sbjct: 379 WDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               D   + P R+   +PQ  +  P   +PF  GPR+CI +  A   + +++   +  F
Sbjct: 439 TVWPDSKVYNPYRFDPDNPQQRS--PLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRF 496

Query: 486 EI 487
            +
Sbjct: 497 RL 498


>BC069351-1|AAH69351.1|  531|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 2 homolog protein.
          Length = 531

 Score = 71.7 bits (168), Expect = 6e-12
 Identities = 47/182 (25%), Positives = 87/182 (47%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTT+   S++L+++A+    Q++  EE+  ++  ++ +E+ 
Sbjct: 319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELE 378

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L++  +    IKESLR  P    + R   +DI L  G  IPKG + +     +   P
Sbjct: 379 WDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               D   + P R+   +PQ  +  P   +PF  GPR+CI +  A   + +++   +  F
Sbjct: 439 TVWPDSKVYNPYRFDPDNPQQRS--PLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRF 496

Query: 486 EI 487
            +
Sbjct: 497 RL 498


>AK096820-1|BAC04868.1|  531|Homo sapiens protein ( Homo sapiens
           cDNA FLJ39501 fis, clone PROST2016980, moderately
           similar to CYTOCHROME P450 4F2 (EC 1.14.13.30). ).
          Length = 531

 Score = 71.7 bits (168), Expect = 6e-12
 Identities = 47/182 (25%), Positives = 87/182 (47%), Gaps = 4/182 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKD-DEIT 366
           +L  +DI       +    DTT+   S++L+++A+    Q++  EE+  ++  ++ +E+ 
Sbjct: 319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELE 378

Query: 367 ADVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIVLK-GYSIPKGTVIVTQNMTSSRLP 425
            D L++  +    IKESLR  P    + R   +DI L  G  IPKG + +     +   P
Sbjct: 379 WDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
               D   + P R+   +PQ  +  P   +PF  GPR+CI +  A   + +++   +  F
Sbjct: 439 TVWPDSKVYNPYRFDPDNPQQRS--PLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRF 496

Query: 486 EI 487
            +
Sbjct: 497 RL 498


>AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score = 70.1 bits (164), Expect = 2e-11
 Identities = 52/191 (27%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT    TS+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 301 QLSDEKIINIVLDLFGAGFDTVTTATSWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +           +
Sbjct: 361 D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIDHDQK 419

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 480 F---SVPLGVK 487


>U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450
           monooxygenase CYP2J2 protein.
          Length = 502

 Score = 69.7 bits (163), Expect = 2e-11
 Identities = 45/168 (26%), Positives = 81/168 (48%), Gaps = 5/168 (2%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRS 378
           +D+  A  +TT+ T  + L ++A     Q+++  E+  ++ +     TA       Y  +
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA-ARESMPYTNA 364

Query: 379 SIKESLRL-NPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPE 437
            I E  R+ N + + + R +  D  L GY +PKGT+I+T      R P     P TF P+
Sbjct: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424

Query: 438 RWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
            ++    Q++    F  +PF  G R+C+  +LA   + I    L+++F
Sbjct: 425 HFLENG-QFKKREAF--MPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score = 69.7 bits (163), Expect = 2e-11
 Identities = 45/168 (26%), Positives = 81/168 (48%), Gaps = 5/168 (2%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRS 378
           +D+  A  +TT+ T  + L ++A     Q+++  E+  ++ +     TA       Y  +
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA-ARESMPYTNA 364

Query: 379 SIKESLRL-NPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPE 437
            I E  R+ N + + + R +  D  L GY +PKGT+I+T      R P     P TF P+
Sbjct: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424

Query: 438 RWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
            ++    Q++    F  +PF  G R+C+  +LA   + I    L+++F
Sbjct: 425 HFLENG-QFKKREAF--MPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score = 69.7 bits (163), Expect = 2e-11
 Identities = 45/168 (26%), Positives = 81/168 (48%), Gaps = 5/168 (2%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRS 378
           +D+  A  +TT+ T  + L ++A     Q+++  E+  ++ +     TA       Y  +
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA-ARESMPYTNA 364

Query: 379 SIKESLRL-NPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPE 437
            I E  R+ N + + + R +  D  L GY +PKGT+I+T      R P     P TF P+
Sbjct: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424

Query: 438 RWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
            ++    Q++    F  +PF  G R+C+  +LA   + I    L+++F
Sbjct: 425 HFLENG-QFKKREAF--MPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>AF491285-1|AAM09532.1|  511|Homo sapiens cytochrome P450 protein.
          Length = 511

 Score = 69.7 bits (163), Expect = 2e-11
 Identities = 54/191 (28%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY IA     Q    EE+  +L  +D     
Sbjct: 299 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCIALYPEHQHRCREEVREILGDQDF-FQW 357

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 358 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 417

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 418 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 476 FSLDPSRLPIK 486


>AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.
          Length = 502

 Score = 69.7 bits (163), Expect = 2e-11
 Identities = 45/168 (26%), Positives = 81/168 (48%), Gaps = 5/168 (2%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRS 378
           +D+  A  +TT+ T  + L ++A     Q+++  E+  ++ +     TA       Y  +
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA-ARESMPYTNA 364

Query: 379 SIKESLRL-NPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPE 437
            I E  R+ N + + + R +  D  L GY +PKGT+I+T      R P     P TF P+
Sbjct: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424

Query: 438 RWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
            ++    Q++    F  +PF  G R+C+  +LA   + I    L+++F
Sbjct: 425 HFLENG-QFKKREAF--MPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 69.3 bits (162), Expect = 3e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHCTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2
           protein.
          Length = 502

 Score = 69.3 bits (162), Expect = 3e-11
 Identities = 45/168 (26%), Positives = 81/168 (48%), Gaps = 5/168 (2%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRS 378
           +D+  A  +TT+ T  + L ++A     Q+++  E+  ++ +     TA       Y  +
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQPSTA-ARESMPYTNA 364

Query: 379 SIKESLRL-NPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPE 437
            I E  R+ N + + + R +  D  L GY +PKGT+I+T      R P     P TF P+
Sbjct: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424

Query: 438 RWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
            ++    Q++    F  +PF  G R+C+  +LA   + I    L+++F
Sbjct: 425 HFLENG-QFKKREAF--MPFSIGKRACLGEQLARTELFIFFTSLMQKF 469


>X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase
           protein.
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDHARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLSSGDAL 459


>M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459


>M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459


>M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459


>M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.
          Length = 494

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>BX679671-8|CAM26071.1|  464|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 464

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 256 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 315

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 316 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 374

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 375 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 428


>BX679671-7|CAM26070.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459


>AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGTHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 257 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 316

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 317 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 375

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 376 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 429


>AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459


>AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 257 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 316

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 317 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 375

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 376 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 429


>AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459


>AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459


>AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 257 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 316

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 317 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 375

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 376 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 429


>AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P450,
           subfamily XXIA (steroid 21-hydroxylase, congenital a
           protein.
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459


>AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens
           cDNA FLJ30054 fis, clone ADRGL1000160, highly similar to
           CYTOCHROME P450 XXIB (EC 1.14.99.10). ).
          Length = 465

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 52/191 (27%), Positives = 90/191 (47%), Gaps = 11/191 (5%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEI 365
           QL    +    VD+L+   +TTA T S+    +  +   Q  + EEL H L P      +
Sbjct: 246 QLQEGHVHMAAVDLLIGGTETTANTLSWAAVFLLHHPEIQQRLQEELDHELGPGASSSRV 305

Query: 366 TADVLSKASYVRSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRL 424
                ++   + ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L
Sbjct: 306 PYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHL 364

Query: 425 PQFIRD-PLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIR 483
            + + + P  F P+R++             +L FG G R C+   LA   + ++L RL++
Sbjct: 365 DETVWERPHEFWPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQ 418

Query: 484 EFEIQWAGEEL 494
            F +  +G+ L
Sbjct: 419 AFTLLPSGDAL 429


>AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 403

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 195 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 254

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 255 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 313

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 314 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 367


>AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 495

 Score = 68.9 bits (161), Expect = 4e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 346

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 347 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 405

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 406 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459


>X16699-1|CAA34672.1|  511|Homo sapiens protein ( Human mRNA for
           cytochrome P-450HP. ).
          Length = 511

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 299 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 357

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 358 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 417

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 418 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 476 FSLDPSRLPIK 486


>J02871-1|AAA35712.1|  511|Homo sapiens protein ( Human lung
           cytochrome P450 (IV subfamily) BI protein, complete cds.
           ).
          Length = 511

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 299 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 357

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 358 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 417

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 418 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 476 FSLDPSRLPIK 486


>DQ518907-1|ABF47106.1|  511|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 511

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 299 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 357

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 358 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 417

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 418 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 476 FSLDPSRLPIK 486


>BC017758-1|AAH17758.1|  512|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 512

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 300 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 358

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 359 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 418

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 419 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 476

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 477 FSLDPSRLPIK 487


>AY151049-1|AAN72312.1|  497|Homo sapiens pulmonary cytochrome P450
           4B1 variant protein.
          Length = 497

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 285 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 343

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 344 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 403

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 404 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 461

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 462 FSLDPSRLPIK 472


>AY151048-1|AAN72311.1|  512|Homo sapiens pulmonary cytochrome P450
           4B1 protein.
          Length = 512

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 300 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 358

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 359 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 418

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 419 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 476

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 477 FSLDPSRLPIK 487


>AY064485-1|AAL57720.1|  511|Homo sapiens cytochrome P450 protein.
          Length = 511

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 299 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 357

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 358 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 417

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 418 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 476 FSLDPSRLPIK 486


>AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 50/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLFHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>AL593856-7|CAI16983.1|  497|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 497

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 285 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 343

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 344 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 403

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 404 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 461

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 462 FSLDPSRLPIK 472


>AL593856-6|CAI16982.1|  512|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 512

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 300 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 358

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 359 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 418

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 419 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 476

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 477 FSLDPSRLPIK 487


>AL593856-5|CAI16981.1|  511|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 511

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 299 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 357

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 358 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 417

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 418 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 476 FSLDPSRLPIK 486


>AL356793-4|CAI22559.1|  511|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 511

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 299 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 357

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 358 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 417

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 418 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 476 FSLDPSRLPIK 486


>AL356793-3|CAI22557.1|  512|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 512

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 300 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 358

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 359 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 418

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 419 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 476

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 477 FSLDPSRLPIK 487


>AL356793-2|CAI22558.1|  497|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 497

 Score = 68.5 bits (160), Expect = 5e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 285 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 343

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 344 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 403

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 404 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 461

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 462 FSLDPSRLPIK 472


>X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.
          Length = 512

 Score = 68.1 bits (159), Expect = 7e-11
 Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 361 D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 480 F---SVPLGVK 487


>EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score = 68.1 bits (159), Expect = 7e-11
 Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 361 D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 480 F---SVPLGVK 487


>BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score = 68.1 bits (159), Expect = 7e-11
 Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 361 D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 480 F---SVPLGVK 487


>AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1
           variant protein.
          Length = 484

 Score = 68.1 bits (159), Expect = 7e-11
 Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 273 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 332

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 333 D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 391

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 392 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 451

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 452 F---SVPLGVK 459


>AY064486-1|AAL57721.1|  511|Homo sapiens cytochrome P450 protein.
          Length = 511

 Score = 68.1 bits (159), Expect = 7e-11
 Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 4/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           +L   D+   +   +    DTT    S+ LY +A     Q    EE+  +L  +D     
Sbjct: 299 KLSDADLRAEVDTFMFEGHDTTTGGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQW 357

Query: 368 DVLSKASYVRSSIKESLRLNPVSIGIGRWLQKDIV-LKGYSIPKGTVIVTQNMTSSRLPQ 426
           D L K +Y+   IKES RL P    + R L K +  + G S+P G++I        R   
Sbjct: 358 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 417

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              DP  F   R+   +      HPF  +PF  GPR+CI ++ A   + ++    +  FE
Sbjct: 418 VWPDPEVFDSLRFSTENASKR--HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFE 475

Query: 487 IQWAGEELGVK 497
                  L +K
Sbjct: 476 FSLDPSRLPIK 486


>AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 251

 Score = 68.1 bits (159), Expect = 7e-11
 Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 40  QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 99

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 100 D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 158

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 159 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 218

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 219 F---SVPLGVK 226


>AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score = 68.1 bits (159), Expect = 7e-11
 Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 361 D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 480 F---SVPLGVK 487


>AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.
          Length = 512

 Score = 68.1 bits (159), Expect = 7e-11
 Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 361 D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 480 F---SVPLGVK 487


>X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.
          Length = 512

 Score = 67.7 bits (158), Expect = 9e-11
 Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 361 D-RSHLPYMEAFILETFRHSSLVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQRVE 479

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 480 F---SVPLGVK 487


>K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.
          Length = 512

 Score = 67.7 bits (158), Expect = 9e-11
 Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 5/191 (2%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 361 D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQRVE 479

Query: 487 IQWAGEELGVK 497
                  LGVK
Sbjct: 480 F---SVPLGVK 487


>M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.
          Length = 230

 Score = 67.3 bits (157), Expect = 1e-10
 Identities = 51/182 (28%), Positives = 90/182 (49%), Gaps = 15/182 (8%)

Query: 319 VDILMAAIDTTAYTTS----FVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKAS 374
           VD+L+   +TTA T S    F+L+H+   +R Q+E+  EL          +     ++  
Sbjct: 22  VDLLIGGTETTANTLSWAVVFLLHHLEIQQRLQEELDHELGP--GASSSRVPYKDRARLP 79

Query: 375 YVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PL 432
            + ++I E LRL P V + +     +   + GY IP+GTVI+  N+  + L + + + P 
Sbjct: 80  LLIATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVII-PNLQGAHLDETVWERPH 138

Query: 433 TFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGE 492
            F P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+
Sbjct: 139 EFWPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGD 192

Query: 493 EL 494
            L
Sbjct: 193 AL 194


>M12079-1|AAA52152.1|  191|Homo sapiens POR protein.
          Length = 191

 Score = 67.3 bits (157), Expect = 1e-10
 Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 2/180 (1%)

Query: 308 QLDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITA 367
           QL  + I+ +++D+  A  DT     S+ L ++  N R Q ++ EEL T++ +      +
Sbjct: 7   QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 66

Query: 368 DVLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQ 426
           D  S   Y+ + I E+ R +  V   I     +D  LKG+ IPKG  +       +   +
Sbjct: 67  D-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 125

Query: 427 FIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFE 486
              +P  F PER++      + +     + FG G R CI   +A   + + L  L++  E
Sbjct: 126 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQRVE 185


>AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score = 66.9 bits (156), Expect = 2e-10
 Identities = 49/180 (27%), Positives = 87/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   + TA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTENTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G R C+   LA   + ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 458


>M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score = 66.5 bits (155), Expect = 2e-10
 Identities = 49/180 (27%), Positives = 88/180 (48%), Gaps = 11/180 (6%)

Query: 319 VDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEEL-HTLLP-KKDDEITADVLSKASYV 376
           VD+L+   +TTA T S+ +  +  +   Q  + EEL H L P      +     ++   +
Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345

Query: 377 RSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRD-PLTF 434
            ++I E LRL PV  + +     +   + GY IP+GTVI+  N+  + L + + + P  F
Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP-NLQGAHLDETVWERPHEF 404

Query: 435 KPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQWAGEEL 494
            P+R++             +L FG G   C+   LA  ++ ++L RL++ F +  +G+ L
Sbjct: 405 WPDRFLEPGKNSR------ALAFGCGAPVCLGEPLARLDLFVVLTRLLQAFTLLPSGDAL 458


>BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 7 protein.
          Length = 494

 Score = 62.5 bits (145), Expect = 3e-09
 Identities = 63/303 (20%), Positives = 131/303 (43%), Gaps = 26/303 (8%)

Query: 200 FLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFS 259
           FL+R    +I  + F +RF+      +D E  S  ++       +       G L++MFS
Sbjct: 173 FLSRTVSNVISSIVFGDRFDY-----EDKEFLSLLSVMLGIFQFTST---STGQLYEMFS 224

Query: 260 TPLYKKLVNSQIYLEKIST---DILIRKINLFESD-DSKNDKSLLKTFLQQPQLDHKD-- 313
           + + K L   Q    K+     D + +K+   +   D  + +  + +FL + Q + K+  
Sbjct: 225 SVM-KHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPN 283

Query: 314 -------IMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEIT 366
                  +M   +++ +A  +T + T  +    + ++   + ++ EE+  ++ K      
Sbjct: 284 TEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKF 343

Query: 367 ADVLSKASYVRSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLP 425
            D  +K  Y+ + I E  R   V  + + R ++KD   + + +PKGT +     +  R P
Sbjct: 344 ED-RAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDP 402

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
            F  +P  F P+ ++    Q++    F  +PF  G R C    LA   + +    +++ F
Sbjct: 403 SFFSNPQDFNPQHFLDDKGQFKKSDAF--VPFSIGKRYCFGEGLARMELFLFFTTVMQNF 460

Query: 486 EIQ 488
            ++
Sbjct: 461 RLK 463


>BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score = 62.5 bits (145), Expect = 3e-09
 Identities = 46/181 (25%), Positives = 85/181 (46%), Gaps = 5/181 (2%)

Query: 309 LDHKDIMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITAD 368
           +  + I+ ++ DI  A  DT     S+ L ++      Q ++ +EL T++ ++     +D
Sbjct: 302 IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSD 361

Query: 369 VLSKASYVRSSIKESLRLNP-VSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQF 427
              +  Y+ + I E+ R +P +   I     +D  L G+ IPK   +       +  P+ 
Sbjct: 362 -RPQLPYLEAFILETFRHSPFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL 420

Query: 428 IRDPLTFKPERWMR--GSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
             DP  F+PER++   G+   + +   + L FG G R CI   LA+  I + L  L+++ 
Sbjct: 421 WEDPSEFRPERFLTADGTAINKPLSEKMML-FGMGKRRCIGEVLAKWEIFLFLAILLQQL 479

Query: 486 E 486
           E
Sbjct: 480 E 480


>M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.
          Length = 494

 Score = 61.7 bits (143), Expect = 6e-09
 Identities = 67/334 (20%), Positives = 143/334 (42%), Gaps = 30/334 (8%)

Query: 200 FLNRLNLEIIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFS 259
           FL+R    +I  + F +RF        D E +   ++ +             G L++MFS
Sbjct: 173 FLSRTVSNVISSIVFGDRF--------DYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFS 224

Query: 260 TPLYKKLVNSQIYLEKIST---DILIRKINLFESD-DSKNDKSLLKTFLQQPQLDHKD-- 313
           + + K L   Q    K+     D + +K+   +   D  + +  + +FL   Q + K+  
Sbjct: 225 SVM-KHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPN 283

Query: 314 -------IMGMMVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEIT 366
                  +M   +++ +A  +T + T  +    + ++   + ++ EE+  ++ K      
Sbjct: 284 TEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKF 343

Query: 367 ADVLSKASYVRSSIKESLRLNPV-SIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLP 425
            D  +K  Y+ + I E  R   V  + + R ++KD   + + +PKGT +     +  R P
Sbjct: 344 ED-RTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDP 402

Query: 426 QFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREF 485
            F  +P  F P+ ++    Q++    F  +PF  G R C    LA   + +    +++ F
Sbjct: 403 SFFSNPQDFNPQHFLDDKGQFKKSDAF--VPFSIGKRYCFGEGLARMELFLFFTTVMQNF 460

Query: 486 EIQ--WAGEELGVKTLLINKPNKP--VSLNFIPR 515
            ++   + +++ V +  +     P   +++F+PR
Sbjct: 461 RLKSSQSPKDIDVSSKHVGFATIPRNYTMSFLPR 494


>AF237982-1|AAF63329.1|  469|Homo sapiens oxysterol
           7alpha-hydroxylase protein.
          Length = 469

 Score = 60.9 bits (141), Expect = 1e-08
 Identities = 46/162 (28%), Positives = 76/162 (46%), Gaps = 9/162 (5%)

Query: 322 LMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIK 381
           L  A+    +T ++VL H   +K    E    +     K   +++ D L K   ++  + 
Sbjct: 275 LSNAVPVAFWTLAYVLSHPDIHKAIM-EGISSVFGKAGKDKIKVSEDDLEKLLLIKWCVL 333

Query: 382 ESLRLNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKPERWMR 441
           E++RL    + I R + K + +  Y IP G +++       R P++  +P  FKPERW +
Sbjct: 334 ETIRLKAPGV-ITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKK 392

Query: 442 GSPQYETIHPFLS--LPFGHGPRSCIAR--RLAEQNICIILM 479
            + +    H FL   + FG G   C AR   L E  +CIIL+
Sbjct: 393 ANLEK---HSFLDCFMAFGSGKFQCPARWFALLEVQMCIILI 431


>BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score = 60.1 bits (139), Expect = 2e-08
 Identities = 40/172 (23%), Positives = 80/172 (46%), Gaps = 4/172 (2%)

Query: 318 MVDILMAAIDTTAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVR 377
           + D+  A  +TT+ T  + L  + +    ++++ EE+  ++         D   +  Y+ 
Sbjct: 293 VADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD-RQEMPYMD 351

Query: 378 SSIKESLR-LNPVSIGIGRWLQKDIVLKGYSIPKGTVIVTQNMTSSRLPQFIRDPLTFKP 436
           + ++E  R +  V   +     +D + +GY IPKGTV+V    +     Q   DP  FKP
Sbjct: 352 AVVREIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKP 411

Query: 437 ERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMRLIREFEIQ 488
           E ++  + +++    F   PF  G R C    LA   + ++L  +++ F ++
Sbjct: 412 EHFLNENGKFKYSDYF--KPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.320    0.136    0.405 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 76,328,809
Number of Sequences: 224733
Number of extensions: 3188516
Number of successful extensions: 6629
Number of sequences better than 10.0: 423
Number of HSP's better than 10.0 without gapping: 317
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 5518
Number of HSP's gapped (non-prelim): 537
length of query: 517
length of database: 73,234,838
effective HSP length: 93
effective length of query: 424
effective length of database: 52,334,669
effective search space: 22189899656
effective search space used: 22189899656
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 67 (31.1 bits)