Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000354-TA|BGIBMGA000354-PA|IPR000024|Frizzled CRD
region, IPR000001|Kringle, IPR001245|Tyrosine protein kinase,
IPR011009|Protein kinase-like, IPR013806|Kringle-like fold,
IPR000719|Protein kinase, IPR008266|Tyrosine protein kinase, active
site, IPR001400|Somatotropin hormone
(638 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase recepto... 840 0.0
UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine prot... 611 e-173
UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole... 536 e-151
UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane r... 450 e-125
UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine prot... 415 e-114
UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane r... 354 4e-96
UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 341 4e-92
UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2; ... 334 4e-90
UniRef50_Q01974 Cluster: Tyrosine-protein kinase transmembrane r... 328 3e-88
UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane r... 305 2e-81
UniRef50_Q4R1V1 Cluster: Neurospecific receptor kinase; n=1; Dap... 300 8e-80
UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3; ... 296 1e-78
UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle spe... 284 6e-75
UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2; ... 272 1e-71
UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor precu... 272 2e-71
UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor precu... 269 2e-70
UniRef50_O76997 Cluster: Putative neurotrophin receptor LTRK 1 p... 246 2e-63
UniRef50_Q16288 Cluster: NT-3 growth factor receptor precursor; ... 244 6e-63
UniRef50_P04629 Cluster: High affinity nerve growth factor recep... 241 5e-62
UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor p... 237 7e-61
UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor p... 231 4e-59
UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin re... 223 9e-57
UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor... 223 9e-57
UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-li... 223 2e-56
UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2; ... 223 2e-56
UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;... 223 2e-56
UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1... 223 2e-56
UniRef50_Q25410 Cluster: Putative molluscan insulin-related pept... 222 3e-56
UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor... 221 3e-56
UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1; ... 221 3e-56
UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1... 221 3e-56
UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror CG4926... 221 5e-56
UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin re... 221 5e-56
UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC 2.7... 220 8e-56
UniRef50_A7SP77 Cluster: Predicted protein; n=1; Nematostella ve... 219 2e-55
UniRef50_Q0P4R9 Cluster: Discoidin domain receptor family, membe... 218 3e-55
UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella ve... 218 3e-55
UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2; Culicidae... 217 7e-55
UniRef50_P14616 Cluster: Insulin receptor-related protein precur... 215 2e-54
UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 215 3e-54
UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5; Caenorha... 213 1e-53
UniRef50_Q70W12 Cluster: Discoidin receptor; n=1; Ciona intestin... 213 2e-53
UniRef50_Q4RPK6 Cluster: Chromosome 12 SCAF15007, whole genome s... 212 2e-53
UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2; ... 212 2e-53
UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p, ... 210 9e-53
UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4 var... 210 9e-53
UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4 pre... 210 9e-53
UniRef50_UPI0000E48069 Cluster: PREDICTED: hypothetical protein;... 210 1e-52
UniRef50_Q5RIU8 Cluster: Novel protein similar to vertebrate dis... 210 1e-52
UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; ... 210 1e-52
UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;... 210 1e-52
UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2; ... 209 2e-52
UniRef50_Q16832 Cluster: Discoidin domain-containing receptor 2 ... 209 2e-52
UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin re... 208 3e-52
UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|R... 208 3e-52
UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2; ... 208 5e-52
UniRef50_Q08345 Cluster: Epithelial discoidin domain-containing ... 208 5e-52
UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC 2.7... 206 2e-51
UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic... 205 2e-51
UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5; ... 205 2e-51
UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming pr... 205 2e-51
UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta ... 205 3e-51
UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor... 204 4e-51
UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Re... 204 6e-51
UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA;... 203 1e-50
UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,... 202 2e-50
UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690; ... 202 2e-50
UniRef50_Q9Y1Y8 Cluster: Protein tyrosine kinase; n=2; Metazoa|R... 202 2e-50
UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3 ... 202 2e-50
UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1 pre... 202 2e-50
UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1; ... 202 3e-50
UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor ... 201 4e-50
UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whol... 200 9e-50
UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3; Eutheria... 200 9e-50
UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase ... 200 9e-50
UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor prec... 199 2e-49
UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming pr... 199 2e-49
UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA... 199 2e-49
UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2 pre... 199 2e-49
UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ... 199 2e-49
UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine p... 198 3e-49
UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=... 198 5e-49
UniRef50_A1IKE0 Cluster: Receptor tyrosine kinase-like orphan re... 197 6e-49
UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:... 197 9e-49
UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin re... 196 1e-48
UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-onco... 196 1e-48
UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosi... 196 1e-48
UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca precur... 196 1e-48
UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK sp... 195 3e-48
UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4; Endoptery... 195 3e-48
UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming pr... 195 3e-48
UniRef50_UPI00015B629F Cluster: PREDICTED: similar to CG33531-PA... 194 5e-48
UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte ... 194 5e-48
UniRef50_UPI0000E468FC Cluster: PREDICTED: similar to KLG; n=3; ... 194 5e-48
UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella ve... 193 1e-47
UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=... 193 1e-47
UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 193 1e-47
UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ... 193 1e-47
UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase ... 193 1e-47
UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca CG... 192 2e-47
UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-li... 192 2e-47
UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18; Eu... 192 2e-47
UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precurso... 192 2e-47
UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|... 191 6e-47
UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 191 6e-47
UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to ENSANGP000... 190 7e-47
UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1; ... 190 7e-47
UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12; Euar... 190 7e-47
UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor precu... 190 1e-46
UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38; Eut... 189 2e-46
UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella ve... 189 2e-46
UniRef50_UPI000065F9C5 Cluster: Epithelial discoidin domain-cont... 188 3e-46
UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-onco... 188 4e-46
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 188 4e-46
UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gamb... 187 9e-46
UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5; Cae... 187 9e-46
UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO pr... 186 2e-45
UniRef50_Q26614 Cluster: Fibroblast growth factor receptor precu... 186 2e-45
UniRef50_Q9GRH2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 186 2e-45
UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora... 186 2e-45
UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250... 185 4e-45
UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep... 185 4e-45
UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella ve... 185 4e-45
UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella ve... 184 6e-45
UniRef50_UPI0000519EF1 Cluster: PREDICTED: similar to CG31640-PA... 184 9e-45
UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:... 184 9e-45
UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome sh... 183 1e-44
UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome sh... 183 1e-44
UniRef50_Q59DZ7 Cluster: CG33531-PA; n=6; Sophophora|Rep: CG3353... 183 1e-44
UniRef50_UPI00015B4B9F Cluster: PREDICTED: similar to prenylcyst... 183 1e-44
UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep... 183 1e-44
UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella ve... 183 1e-44
UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 182 2e-44
UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein ... 182 3e-44
UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41... 182 3e-44
UniRef50_UPI0000D576E5 Cluster: PREDICTED: similar to CG33531-PA... 182 3e-44
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 182 3e-44
UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephr... 181 5e-44
UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;... 180 8e-44
UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homol... 180 8e-44
UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA... 180 1e-43
UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 180 1e-43
UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homol... 180 1e-43
UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;... 180 1e-43
UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona intestinali... 180 1e-43
UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protei... 179 2e-43
UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77; E... 179 2e-43
UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Re... 177 6e-43
UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 177 6e-43
UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2; ... 177 6e-43
UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 177 7e-43
UniRef50_Q25198 Cluster: Receptor tyrosine kinase 90; n=1; Hydra... 177 1e-42
UniRef50_Q17HL3 Cluster: Discoidin domain receptor; n=3; Culicid... 177 1e-42
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 177 1e-42
UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n... 176 1e-42
UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella ve... 176 1e-42
UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome sh... 176 2e-42
UniRef50_Q95ZV7 Cluster: Putative uncharacterized protein; n=3; ... 176 2e-42
UniRef50_Q674V1 Cluster: Vascular endothelial growth factor rece... 176 2e-42
UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 175 3e-42
UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 175 4e-42
UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1 ... 175 4e-42
UniRef50_O16131 Cluster: Insulin receptor homolog precursor; n=2... 174 5e-42
UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Re... 173 9e-42
UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella ve... 173 9e-42
UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hyd... 173 9e-42
UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase ... 173 9e-42
UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=3... 173 9e-42
UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1 pre... 173 1e-41
UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberite... 173 2e-41
UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor precu... 173 2e-41
UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,... 172 2e-41
UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus ... 172 2e-41
UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona intestinali... 172 2e-41
UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep: E... 172 3e-41
UniRef50_Q4SFK0 Cluster: Chromosome 7 SCAF14601, whole genome sh... 171 4e-41
UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56; n... 171 4e-41
UniRef50_Q9GRH1 Cluster: Tyrosine-protein kinase receptor; n=4; ... 171 4e-41
UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gamb... 171 4e-41
UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=5... 171 5e-41
UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precurs... 171 6e-41
UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome s... 171 6e-41
UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome s... 170 1e-40
UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 170 1e-40
UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Re... 170 1e-40
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 170 1e-40
UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=1... 170 1e-40
UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n... 169 1e-40
UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whol... 169 2e-40
UniRef50_Q9Y1X7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 169 2e-40
UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to protein-ty... 169 3e-40
UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;... 168 3e-40
UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: E... 168 3e-40
UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to ENSANGP000... 168 5e-40
UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1... 168 5e-40
UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma m... 168 5e-40
UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111; Euteleo... 168 5e-40
UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precurs... 167 6e-40
UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precurs... 167 6e-40
UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like pro... 167 6e-40
UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Eph... 167 8e-40
UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -... 167 1e-39
UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella ve... 167 1e-39
UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|... 166 1e-39
UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n... 166 1e-39
UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47; E... 166 1e-39
UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54; Gnat... 166 1e-39
UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4; Caenorhabd... 166 2e-39
UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whol... 166 2e-39
UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=1... 166 2e-39
UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15 ... 166 2e-39
UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6; En... 165 2e-39
UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome sh... 165 3e-39
UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9; Cl... 164 6e-39
UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|R... 164 6e-39
UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monos... 164 6e-39
UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor; ... 164 6e-39
UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella ve... 164 7e-39
UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=3... 164 7e-39
UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 163 1e-38
UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2; Cul... 163 2e-38
UniRef50_UPI0000E47A46 Cluster: PREDICTED: similar to ret protei... 162 2e-38
UniRef50_UPI0000DB6C79 Cluster: PREDICTED: similar to PTK7 prote... 162 3e-38
UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon nigrovi... 162 3e-38
UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein ty... 161 4e-38
UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome sh... 161 4e-38
UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 161 7e-38
UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23; Ther... 161 7e-38
UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor recep... 160 9e-38
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 160 1e-37
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 160 1e-37
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 160 1e-37
UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2; Anthomedu... 160 1e-37
UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n... 160 1e-37
UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome s... 159 2e-37
UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to tyrosine-p... 159 2e-37
UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;... 159 2e-37
UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like t... 159 2e-37
UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistos... 159 2e-37
UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Cion... 159 2e-37
UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=... 159 3e-37
UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming pr... 159 3e-37
UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 158 4e-37
UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona ... 158 4e-37
UniRef50_UPI000065D1E0 Cluster: BDNF/NT-3 growth factors recepto... 158 5e-37
UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whol... 158 5e-37
UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2; S... 157 6e-37
UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1; ... 157 6e-37
UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Da... 157 8e-37
UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3; ... 157 8e-37
UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n... 156 1e-36
UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whol... 156 2e-36
UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella ve... 156 2e-36
UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=2... 156 2e-36
UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella ve... 155 3e-36
UniRef50_P42159 Cluster: Class II receptor tyrosine kinase; n=5;... 155 3e-36
UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n... 155 3e-36
UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin... 155 3e-36
UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hyd... 155 3e-36
UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86; Coel... 155 3e-36
UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor... 155 3e-36
UniRef50_Q03351 Cluster: NT-3 growth factor receptor precursor; ... 155 3e-36
UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming pr... 155 5e-36
UniRef50_Q4L0H7 Cluster: Insulin receptor tyrosine kinase; n=2; ... 154 6e-36
UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX... 154 6e-36
UniRef50_Q0MQ66 Cluster: Putative uncharacterized protein; n=5; ... 154 8e-36
UniRef50_P00533 Cluster: Epidermal growth factor receptor precur... 154 8e-36
UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precu... 153 1e-35
UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep: ... 153 1e-35
UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6; Eume... 153 2e-35
UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2; ... 153 2e-35
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 153 2e-35
UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4... 153 2e-35
UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 152 2e-35
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 152 3e-35
UniRef50_Q6W5B1 Cluster: TEL/JAK2 fusion protein; n=4; Danio rer... 151 4e-35
UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga... 151 6e-35
UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3; ... 151 7e-35
UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:1... 150 1e-34
UniRef50_Q7PT15 Cluster: ENSANGP00000009263; n=2; Culicidae|Rep:... 150 1e-34
UniRef50_A7RX97 Cluster: Predicted protein; n=1; Nematostella ve... 150 1e-34
UniRef50_O60674 Cluster: Tyrosine-protein kinase JAK2; n=48; Eut... 150 1e-34
UniRef50_UPI00015B6067 Cluster: PREDICTED: similar to tyrosine p... 150 1e-34
UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack CG1499... 150 1e-34
UniRef50_Q9N3S5 Cluster: Putative uncharacterized protein; n=4; ... 150 1e-34
UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor t... 149 2e-34
UniRef50_UPI0000DB72A0 Cluster: PREDICTED: similar to R151.4a; n... 149 2e-34
UniRef50_UPI000065DACB Cluster: Homolog of Homo sapiens "Splice ... 149 2e-34
UniRef50_Q4SF69 Cluster: Chromosome undetermined SCAF14608, whol... 149 2e-34
UniRef50_UPI0000E47C0F Cluster: PREDICTED: similar to focal adhe... 149 2e-34
UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kin... 149 2e-34
UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular ... 149 2e-34
UniRef50_Q9Y1Y0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 149 2e-34
UniRef50_O76809 Cluster: Receptor tyrosine kinase HTK30; n=1; Hy... 149 2e-34
UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32; Eute... 149 2e-34
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 149 3e-34
UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92... 149 3e-34
UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Cio... 149 3e-34
UniRef50_UPI00015B6341 Cluster: PREDICTED: similar to KLG; n=1; ... 148 4e-34
UniRef50_UPI0000D56AE3 Cluster: PREDICTED: similar to CG1594-PA;... 148 4e-34
UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP099... 148 4e-34
UniRef50_UPI00006A1E7A Cluster: Non-receptor tyrosine-protein ki... 148 5e-34
UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA... 147 7e-34
UniRef50_Q22489 Cluster: Putative uncharacterized protein; n=4; ... 147 7e-34
UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3; Culicidae|... 147 7e-34
UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11; Mammal... 147 7e-34
UniRef50_Q96Q04 Cluster: Serine/threonine-protein kinase LMTK3 p... 147 7e-34
UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whol... 147 9e-34
UniRef50_Q5JZY3 Cluster: Ephrin type-A receptor 10 precursor; n=... 147 9e-34
UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase... 146 1e-33
UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55; E... 146 1e-33
UniRef50_UPI0000E49426 Cluster: PREDICTED: hypothetical protein;... 146 2e-33
UniRef50_Q21041 Cluster: Putative uncharacterized protein ver-4;... 146 2e-33
UniRef50_UPI000069F079 Cluster: Serine/threonine-protein kinase ... 146 2e-33
UniRef50_Q8T0W6 Cluster: Putative insulin receptor precursor; n=... 146 2e-33
UniRef50_O45232 Cluster: Putative uncharacterized protein ark-1;... 146 2e-33
UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family... 144 5e-33
UniRef50_UPI0000DB7B4C Cluster: PREDICTED: similar to hopscotch ... 144 5e-33
UniRef50_UPI0000D563AD Cluster: PREDICTED: similar to CG3969-PA,... 144 5e-33
UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12; Tetr... 144 5e-33
UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep: Ty... 144 5e-33
UniRef50_O76411 Cluster: Suppressor of constitutive dauer format... 144 5e-33
UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosin... 144 6e-33
UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2 pre... 144 6e-33
UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome sh... 144 8e-33
UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1; ... 144 8e-33
UniRef50_UPI0000F1D883 Cluster: PREDICTED: hypothetical protein;... 143 1e-32
UniRef50_UPI0000EB1EAB Cluster: Serine/threonine-protein kinase ... 143 1e-32
UniRef50_Q6ZMQ8-3 Cluster: Isoform 3 of Q6ZMQ8 ; n=6; Tetrapoda|... 143 1e-32
UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep: CG1499... 143 1e-32
UniRef50_O61460 Cluster: Ephrin receptor 1 precursor; n=3; Caeno... 143 1e-32
UniRef50_Q6ZMQ8 Cluster: Serine/threonine-protein kinase LMTK1; ... 143 1e-32
UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hy... 142 2e-32
UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CS... 142 2e-32
UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;... 142 3e-32
UniRef50_UPI0000DB7238 Cluster: PREDICTED: similar to Discoidin ... 141 5e-32
UniRef50_UPI00006A0A62 Cluster: High affinity nerve growth facto... 141 5e-32
UniRef50_A4IIX3 Cluster: Putative uncharacterized protein; n=1; ... 141 5e-32
UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24; Euteleo... 141 6e-32
UniRef50_A7RL50 Cluster: Predicted protein; n=1; Nematostella ve... 140 8e-32
UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase ... 140 8e-32
UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole... 140 1e-31
UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-prote... 140 1e-31
UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep: Zgc:1... 140 1e-31
UniRef50_Q19726 Cluster: Putative uncharacterized protein kin-14... 140 1e-31
UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13; Euteleo... 140 1e-31
UniRef50_UPI00015B46B5 Cluster: PREDICTED: similar to CG33531-PA... 139 2e-31
UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC 2.7... 139 2e-31
UniRef50_Q4S8H3 Cluster: Chromosome 2 SCAF14705, whole genome sh... 139 2e-31
UniRef50_Q8UVR8 Cluster: Macrophage colony-stimulating factor 1 ... 139 2e-31
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 139 2e-31
UniRef50_Q4SUM3 Cluster: Ephrin receptor; n=4; Tetraodon nigrovi... 139 2e-31
UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome s... 139 2e-31
UniRef50_Q4JDD5 Cluster: Tyrosine-protein kinase receptor; n=5; ... 139 2e-31
UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep: M... 139 2e-31
UniRef50_P35968 Cluster: Vascular endothelial growth factor rece... 139 2e-31
UniRef50_UPI000065E56D Cluster: EPHB1_HUMAN Isoform 3 of P54762 ... 138 3e-31
UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2; C... 138 3e-31
UniRef50_P23458 Cluster: Tyrosine-protein kinase JAK1; n=55; Eut... 138 3e-31
UniRef50_Q0IFX6 Cluster: Pdgf/vegf receptor; n=1; Aedes aegypti|... 138 6e-31
UniRef50_UPI00015B5A01 Cluster: PREDICTED: similar to protein ki... 137 7e-31
UniRef50_Q21038 Cluster: Putative uncharacterized protein ver-3;... 137 7e-31
UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA... 137 1e-30
UniRef50_Q61B52 Cluster: Putative uncharacterized protein CBG134... 136 1e-30
UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC ... 136 2e-30
UniRef50_Q8T0Z7 Cluster: Tyrosine kinase-like protein; n=1; Bomb... 136 2e-30
UniRef50_Q24327 Cluster: Gp160-Dtrk precursor; n=4; Sophophora|R... 136 2e-30
UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase ... 136 2e-30
UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma man... 136 2e-30
UniRef50_Q9N4T2 Cluster: Putative uncharacterized protein Y50D4B... 136 2e-30
UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2... 136 2e-30
UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21; Deut... 136 2e-30
UniRef50_Q4SJQ3 Cluster: Tyrosine-protein kinase receptor; n=1; ... 135 3e-30
UniRef50_Q7PMY4 Cluster: ENSANGP00000014155; n=2; Culicidae|Rep:... 135 3e-30
UniRef50_Q9VLQ8 Cluster: CG8222-PA, isoform A; n=8; Sophophora|R... 134 5e-30
UniRef50_Q8T4M0 Cluster: VEGFR-A splice form A; n=4; Diptera|Rep... 134 5e-30
UniRef50_Q15516 Cluster: Tyrosine kinase; n=1; Homo sapiens|Rep:... 134 5e-30
UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4; ... 134 7e-30
UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23... 134 7e-30
UniRef50_UPI00015B629D Cluster: PREDICTED: similar to CG33531-PA... 134 9e-30
UniRef50_Q5G254 Cluster: Erbb3; n=6; Danio rerio|Rep: Erbb3 - Da... 134 9e-30
UniRef50_Q5BXN9 Cluster: SJCHGC05493 protein; n=1; Schistosoma j... 134 9e-30
UniRef50_O17391 Cluster: Protein kinase protein 9, isoform b; n=... 134 9e-30
UniRef50_UPI00015B5C00 Cluster: PREDICTED: similar to VEGFR-A sp... 133 1e-29
UniRef50_UPI0000D576E4 Cluster: PREDICTED: similar to CG33531-PA... 133 1e-29
UniRef50_P10721 Cluster: Mast/stem cell growth factor receptor p... 133 1e-29
UniRef50_Q1HTP1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 133 2e-29
UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae... 133 2e-29
UniRef50_Q17IF1 Cluster: Receptor protein tyrosine kinase; n=1; ... 133 2e-29
UniRef50_UPI00015B55E4 Cluster: PREDICTED: similar to receptor-l... 132 2e-29
UniRef50_Q9PWD1 Cluster: Tyrosine-protein kinase; n=3; Tetraodon... 132 2e-29
UniRef50_Q640T5 Cluster: Tyrosine-protein kinase receptor; n=2; ... 132 2e-29
UniRef50_UPI0000F1F8B4 Cluster: PREDICTED: hypothetical protein;... 132 4e-29
UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3... 131 5e-29
UniRef50_UPI0000DB7A0A Cluster: PREDICTED: similar to FMS-like t... 131 6e-29
UniRef50_Q25199 Cluster: Tyrosine kinase receptor; n=7; Hydra|Re... 131 6e-29
UniRef50_Q23554 Cluster: Putative uncharacterized protein; n=1; ... 131 6e-29
UniRef50_A7RGV3 Cluster: Predicted protein; n=1; Nematostella ve... 131 6e-29
UniRef50_Q8AXB3 Cluster: Vascular endothelial growth factor rece... 131 6e-29
UniRef50_Q4T1R9 Cluster: Chromosome 4 SCAF10492, whole genome sh... 130 8e-29
UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine ki... 130 8e-29
UniRef50_Q8IQ00 Cluster: CG3277-PB, isoform B; n=3; Sophophora|R... 130 8e-29
UniRef50_P17948 Cluster: Vascular endothelial growth factor rece... 130 8e-29
UniRef50_P18475 Cluster: Tyrosine-protein kinase receptor torso ... 130 8e-29
UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2; Sop... 130 8e-29
UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=5... 130 8e-29
UniRef50_UPI00005A2D48 Cluster: PREDICTED: similar to EPH recept... 130 1e-28
UniRef50_Q9Y1Y4 Cluster: Tyrosine-protein kinase; n=1; Ephydatia... 130 1e-28
UniRef50_Q17833 Cluster: Putative uncharacterized protein old-1;... 130 1e-28
UniRef50_Q96HF4 Cluster: EPHA2 protein; n=3; Amniota|Rep: EPHA2 ... 130 1e-28
UniRef50_P16234 Cluster: Alpha-type platelet-derived growth fact... 130 1e-28
UniRef50_Q8JFR5 Cluster: Mast/stem cell growth factor receptor p... 130 1e-28
UniRef50_UPI00015B6363 Cluster: PREDICTED: similar to tyrosine p... 130 1e-28
UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 130 1e-28
UniRef50_UPI0000D55944 Cluster: PREDICTED: similar to CG8967-PA;... 129 2e-28
UniRef50_P79884 Cluster: Insulin-like growth factor-I receptor; ... 129 2e-28
UniRef50_Q24592 Cluster: Tyrosine-protein kinase hopscotch; n=2;... 129 2e-28
UniRef50_P04412 Cluster: Epidermal growth factor receptor precur... 129 2e-28
UniRef50_P07333 Cluster: Macrophage colony-stimulating factor 1 ... 129 2e-28
UniRef50_Q4TFI7 Cluster: Chromosome undetermined SCAF4439, whole... 129 3e-28
UniRef50_Q4H3A3 Cluster: Janus kinase; n=1; Ciona intestinalis|R... 128 3e-28
UniRef50_Q16VL6 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 128 3e-28
UniRef50_Q16RK6 Cluster: Receptor protein tyrosine kinase; n=1; ... 128 3e-28
UniRef50_P35916 Cluster: Vascular endothelial growth factor rece... 128 3e-28
UniRef50_Q5GIT4 Cluster: Vascular endothelial growth factor rece... 128 3e-28
UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5; Eutel... 128 3e-28
UniRef50_UPI0000D8BE91 Cluster: UPI0000D8BE91 related cluster; n... 128 6e-28
UniRef50_O12990 Cluster: Tyrosine-protein kinase Jak1; n=8; Eute... 128 6e-28
UniRef50_Q27HR1 Cluster: Ret tyrosine-kinase receptor; n=1; Bran... 126 1e-27
UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1; Gir... 126 1e-27
UniRef50_UPI00004CFD13 Cluster: Serine/threonine-protein kinase ... 126 2e-27
UniRef50_Q7Q0U2 Cluster: ENSANGP00000012311; n=1; Anopheles gamb... 126 2e-27
UniRef50_UPI0000E470E3 Cluster: PREDICTED: similar to Fer, parti... 125 4e-27
UniRef50_UPI0000F306DC Cluster: Serine/threonine-protein kinase ... 125 4e-27
UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; ... 125 4e-27
UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1; ... 125 4e-27
UniRef50_Q13470 Cluster: Non-receptor tyrosine-protein kinase TN... 125 4e-27
UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus multilo... 124 6e-27
UniRef50_Q9V422 Cluster: Tyrosine-protein kinase Dnt precursor; ... 124 6e-27
UniRef50_P34265 Cluster: Probable tyrosine-protein kinase kin-31... 124 6e-27
UniRef50_Q9U8U8 Cluster: VEGFR-like; n=1; Branchiostoma belcheri... 124 7e-27
UniRef50_A7RNB2 Cluster: Predicted protein; n=1; Nematostella ve... 124 1e-26
UniRef50_O15197 Cluster: Ephrin type-B receptor 6 precursor; n=2... 124 1e-26
UniRef50_UPI0000F1DBB6 Cluster: PREDICTED: hypothetical protein;... 123 1e-26
UniRef50_Q10925-2 Cluster: Isoform b of Q10925 ; n=2; Caenorhabd... 123 1e-26
UniRef50_Q10925 Cluster: Probable tyrosine-protein kinase kin-25... 123 1e-26
UniRef50_Q2MHE4 Cluster: Serine/threonine-protein kinase HT1; n=... 123 1e-26
UniRef50_Q9GZG1 Cluster: Putative uncharacterized protein; n=6; ... 123 2e-26
UniRef50_Q9I8N6 Cluster: Macrophage colony-stimulating factor 1 ... 122 2e-26
UniRef50_Q9U8U9 Cluster: PDGFR-like; n=1; Eptatretus burgeri|Rep... 121 5e-26
UniRef50_Q4S6E0 Cluster: Chromosome 10 SCAF14728, whole genome s... 121 5e-26
UniRef50_Q4S1M5 Cluster: Chromosome 6 SCAF14768, whole genome sh... 121 5e-26
UniRef50_UPI0000E49042 Cluster: PREDICTED: similar to RE05926p; ... 121 7e-26
UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;... 121 7e-26
UniRef50_Q61G93 Cluster: Putative uncharacterized protein CBG113... 121 7e-26
UniRef50_Q6GPK5 Cluster: Tyrosine-protein kinase; n=4; Euteleost... 120 9e-26
UniRef50_Q17PG3 Cluster: Tyrosine-protein kinase drl; n=5; Endop... 120 9e-26
UniRef50_UPI000065D8B4 Cluster: Basic fibroblast growth factor r... 120 1e-25
UniRef50_Q68KJ7 Cluster: HER2; n=3; Amniota|Rep: HER2 - Felis si... 119 3e-25
UniRef50_Q27324 Cluster: Tyrosine-protein kinase Drl precursor; ... 119 3e-25
UniRef50_P34892 Cluster: Receptor-like tyrosine-protein kinase k... 118 4e-25
UniRef50_UPI00015B54DC Cluster: PREDICTED: similar to vascular e... 118 5e-25
UniRef50_UPI0000E4A99A Cluster: PREDICTED: similar to tyrosine k... 118 5e-25
UniRef50_UPI0000E257E1 Cluster: PREDICTED: similar to tyrosine k... 118 5e-25
UniRef50_UPI000065E468 Cluster: Homolog of Gallus gallus "Ephrin... 118 5e-25
UniRef50_Q6SAW1 Cluster: Epidermal growth factor receptor; n=70;... 118 5e-25
UniRef50_Q61BE2 Cluster: Putative uncharacterized protein CBG133... 118 5e-25
UniRef50_P79749 Cluster: Beta-type platelet-derived growth facto... 118 5e-25
UniRef50_Q4SMB8 Cluster: Chromosome 3 SCAF14553, whole genome sh... 118 6e-25
UniRef50_Q4RQT4 Cluster: Chromosome 2 SCAF15004, whole genome sh... 117 1e-24
UniRef50_Q9Y1Z4 Cluster: Protein tyrosine kinase 37; n=1; Hydra ... 117 1e-24
UniRef50_P34891 Cluster: Receptor-like tyrosine-protein kinase k... 116 2e-24
UniRef50_Q4RXV8 Cluster: Chromosome 11 SCAF14979, whole genome s... 116 3e-24
UniRef50_Q9XW34 Cluster: Putative uncharacterized protein; n=3; ... 115 4e-24
UniRef50_Q9M085 Cluster: Protein kinase-like protein; n=22; Magn... 114 6e-24
UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Re... 114 6e-24
UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;... 114 6e-24
UniRef50_Q60WJ5 Cluster: Putative uncharacterized protein CBG191... 114 6e-24
UniRef50_Q19238 Cluster: Putative tyrosine-protein kinase F09A5.... 114 8e-24
UniRef50_Q6J9G0 Cluster: Tyrosine protein-kinase STYK1; n=20; Am... 114 8e-24
UniRef50_P36888 Cluster: FL cytokine receptor precursor; n=33; A... 113 1e-23
UniRef50_Q613B1 Cluster: Putative uncharacterized protein CBG164... 113 1e-23
UniRef50_O76698 Cluster: Vegf (Vascular endothelial growth facto... 113 1e-23
UniRef50_Q5TCX8 Cluster: Mitogen-activated protein kinase kinase... 113 2e-23
UniRef50_Q5TRF2 Cluster: ENSANGP00000025511; n=1; Anopheles gamb... 112 3e-23
UniRef50_Q26566 Cluster: Epidermal growth factor receptor precur... 112 3e-23
UniRef50_Q16LR4 Cluster: Tyrosine protein kinase; n=5; Coelomata... 112 3e-23
UniRef50_UPI00015B55E2 Cluster: PREDICTED: similar to tyrosine-p... 111 4e-23
UniRef50_UPI0000DB74F2 Cluster: PREDICTED: similar to Derailed 2... 111 6e-23
UniRef50_P09619 Cluster: Beta-type platelet-derived growth facto... 111 6e-23
UniRef50_UPI00015B4A8D Cluster: PREDICTED: similar to receptor t... 110 1e-22
UniRef50_A2E1W1 Cluster: TKL family protein kinase; n=1; Trichom... 109 2e-22
UniRef50_UPI0000584AF8 Cluster: PREDICTED: similar to Expressed ... 109 3e-22
UniRef50_Q4RP85 Cluster: Tyrosine-protein kinase receptor; n=3; ... 109 3e-22
UniRef50_O02064 Cluster: Putative uncharacterized protein; n=1; ... 108 4e-22
UniRef50_Q4RHE1 Cluster: Chromosome 3 SCAF15050, whole genome sh... 108 5e-22
UniRef50_Q21867 Cluster: Putative uncharacterized protein; n=2; ... 108 5e-22
UniRef50_Q21868 Cluster: Putative uncharacterized protein; n=1; ... 107 9e-22
UniRef50_Q16RU6 Cluster: Mitogen-activated protein kinase kinase... 107 9e-22
UniRef50_O17408 Cluster: Putative uncharacterized protein; n=1; ... 107 9e-22
>UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase receptor;
n=5; Endopterygota|Rep: Muscle-specific tyrosine kinase
receptor - Aedes aegypti (Yellowfever mosquito)
Length = 666
Score = 840 bits (2079), Expect = 0.0
Identities = 382/619 (61%), Positives = 478/619 (77%), Gaps = 18/619 (2%)
Query: 20 YCGPYNGQVCKSYSTG-YVWYNH--TGGLDNEKITSGLWKEMISNLQEPCRTQAERLLCA 76
YC PYNG+VCK++ G VWYN +GG NE+IT+ L++++I++L + CR AE+LLCA
Sbjct: 48 YCAPYNGKVCKTFVKGRQVWYNRDGSGGWLNEQITTALFRDLITDLPDYCRPAAEKLLCA 107
Query: 77 YAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLPEC 136
+AFP+C+ +DGV LPLCYEDC+A +QFCYNDW +IE++KERG +SRGHFRLP C
Sbjct: 108 FAFPQCVIRDGVTV-RLPLCYEDCVATHLQFCYNDWALIEEKKERGDVIKSRGHFRLPNC 166
Query: 137 ENLPHYSGKGSQVSCNNIGITDMDLDQVTTTCVKGNGRYYQGVINETKAGLACQAWESQF 196
E+LP Y+ +C+++G+T++ ++VT C GNGRYY G +N T G+ CQ W+SQ
Sbjct: 167 EDLPRYNKTARHSTCSHVGLTELIQEEVTYDCRMGNGRYYLGTVNVTATGIPCQKWDSQE 226
Query: 197 PHQHTRPPLVFPEVQNSSNYCRNAGGEENRPWCYTMHPNVRWQYCEIPMCANSSREKDNI 256
PH H +PPLVF E+Q++ NYCRNAGGEE PWCYT VRWQ C+IP+C NS+
Sbjct: 227 PHSHHKPPLVFAELQDAENYCRNAGGEEPTPWCYTTDKAVRWQACDIPLCPNSTDMSATK 286
Query: 257 KGSNLIMENYFTPTFVLLLSIGGLGCVLAIAGIALLCHYIVKNHYSK------CNVSSRR 310
K N++ME+ FTP+ + LLS G ++ + + LC+ I + + ++ N +S +
Sbjct: 287 KPVNIVMESVFTPSMIFLLSGIGFVAIVLLHLLVFLCYRIARYNRNRRQGAAGYNTTSTQ 346
Query: 311 NLQNMDIDLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPG 370
+ Q ID++KLPSN+ YH TGAQLNPKLEKLEFPRNNIIYI+DLGQGAFGRVFQAKAPG
Sbjct: 347 DTQG--IDINKLPSNVNYHRTGAQLNPKLEKLEFPRNNIIYIKDLGQGAFGRVFQAKAPG 404
Query: 371 LIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFE 430
LI E+FTLVAVKMLKDEAS DLQ+DFEREACLLA+FDHPNIVKLLGVCAIGRPMCLLFE
Sbjct: 405 LIAGEDFTLVAVKMLKDEASQDLQVDFEREACLLAEFDHPNIVKLLGVCAIGRPMCLLFE 464
Query: 431 YMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKF 490
+M +GDLNE+LR CS P + IA QIASGM+YLS+RKF
Sbjct: 465 FMARGDLNEFLRQCS------PFAQQNRADNITTELSHGDLLSIASQIASGMVYLSERKF 518
Query: 491 VHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTL 550
VHRDLATRNCLI+D+MVVKIADFGLSHKIYLQDYYKGDE+DAIP+RWMPLESILYNKYT+
Sbjct: 519 VHRDLATRNCLIDDNMVVKIADFGLSHKIYLQDYYKGDENDAIPIRWMPLESILYNKYTI 578
Query: 551 ESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNH 610
ESDVWAYGVCLWEIFSFA+QPY+GMTHEEVV+F+K+ N+L+CP+NTP VYDLM++CW+
Sbjct: 579 ESDVWAYGVCLWEIFSFAMQPYYGMTHEEVVKFVKEGNMLSCPENTPLTVYDLMRKCWSR 638
Query: 611 NPSDRPNFRVIYQTLDNIQ 629
P+DRP+F +I+Q L I+
Sbjct: 639 KPADRPSFPIIFQKLQQIR 657
>UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=18; Gnathostomata|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Gallus gallus (Chicken)
Length = 947
Score = 611 bits (1510), Expect = e-173
Identities = 296/626 (47%), Positives = 398/626 (63%), Gaps = 21/626 (3%)
Query: 20 YCGPYNGQVCKSYST--GYVWYNHTGGLDNEK---ITSGLWKEMISNLQEPCRTQAERLL 74
YC Y G+VC + + V++N + E + W E+ + C+ AE LL
Sbjct: 316 YCSTYRGEVCSAILSRNALVFFNSSYADPEETQELLVHTAWTEL-KTVSSFCQPAAESLL 374
Query: 75 CAYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLP 134
C Y F +C GVG P+C E+C+AVK +C+ +W+ +E+ +RG++ LP
Sbjct: 375 CNYIFQEC-KPSGVGPAPKPICRENCLAVKDLYCFKEWLSMEENSQRGIYKPGLMLLALP 433
Query: 135 ECENLPHYSGKGSQVSCNNIGITDMDLDQVTTTCVKGNGRYYQGVINETKAGLACQAWES 194
EC LP S +C +I D + +T TC GNG++YQG N T +G+ CQ W
Sbjct: 434 ECNRLPSLHQDPS--ACTHIPFFDFKKENITRTCYSGNGQFYQGWANVTASGIPCQKWSD 491
Query: 195 QFPHQHTRPPLVFPEVQNSSNYCRNAGGEENRPWCYTMHPNVRWQYCEIPMCANSS---- 250
Q PH H R P VFPE+ ++ NYCRN GGE RPWCYT P+V W+YC + C ++S
Sbjct: 492 QAPHLHRRTPQVFPELSDAENYCRNPGGENERPWCYTKDPSVTWEYCSVSPCGDASLSLG 551
Query: 251 REKDNIKGSNLIMENYFTPTF---VLLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVS 307
K N + NL ++PT+ V++L I ++ + I L+C K +K S
Sbjct: 552 TRKPNGETQNLPPPPSYSPTYSMNVIILIISSFALIVILGIITLVCCRRRKQWKNKKRES 611
Query: 308 SRRNLQNM--DIDLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQ 365
L + ++ LD+L N Y LNPKL LE+PRNNI Y+RD+G+GAFGRVFQ
Sbjct: 612 ETPTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQ 671
Query: 366 AKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPM 425
A+APGL+P E FT+VAVKMLK+EAS D+Q DF+REA L+A+FD+PNIVKLLGVCA+G+PM
Sbjct: 672 ARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPM 731
Query: 426 CLLFEYMGKGDLNEYLRACSTVTSFAPVE---HREXXXXXXXXXXXXXXXXIARQIASGM 482
CLLFEYM GDLNEYLR S + V+ IA+Q+A+GM
Sbjct: 732 CLLFEYMAYGDLNEYLRDRSPRNLCSLVQGGLEARACLLNPLALCCTSQLCIAKQVAAGM 791
Query: 483 LYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLES 542
YLS+RKFVHRDLATRNCL+ ++MVVKIADFGLS +Y DYYK +E+DAIP+RWMP ES
Sbjct: 792 AYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNMYSADYYKANENDAIPIRWMPPES 851
Query: 543 ILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYD 602
I YN+YT ESDVWAYGV LWEIFS+ +QPY+GM HEEV+ +++D N+L+CPDN P +Y+
Sbjct: 852 IFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRDGNILSCPDNCPLELYN 911
Query: 603 LMKQCWNHNPSDRPNFRVIYQTLDNI 628
LM+ CW+ P+DRP+F I++ L+ +
Sbjct: 912 LMRLCWSKLPADRPSFASIHRILERM 937
>UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF7099, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1000
Score = 536 bits (1323), Expect = e-151
Identities = 289/664 (43%), Positives = 380/664 (57%), Gaps = 72/664 (10%)
Query: 20 YCGPYNGQVCKSY--STGYVWYNHT--GGLD-NEKITSGLWKEMISNLQEPCRTQAERLL 74
YC Y G VC++ V++N + D E + LW + L C LL
Sbjct: 353 YCSGYRGDVCRAILQDDQLVFFNSSLPDPEDLQEYLVQSLWPAL-EGLGAACGPAMHSLL 411
Query: 75 CAYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQK--ERGVFFESRGHFR 132
C AFP C N G G P+C E C+AVK +C +W V+E + G+F + G R
Sbjct: 412 CHSAFPDC-NPSGFGPAPKPVCREHCLAVKELYCQREWAVLEGSASAQSGLFRSATGSSR 470
Query: 133 ----LPECENLPHYSGKGSQVSCNNIGITDMDLDQVTTTCVKGNGRYYQGVINETKAGLA 188
LP C+ LP S C ++ TD+ DQ+TT+C GR+YQG +N T++G
Sbjct: 471 PSSLLPNCQALP--SLHADPDICTHVPFTDIKTDQITTSCYSDRGRFYQGGVNVTRSGTP 528
Query: 189 CQAWESQ----------------FPHQHTRPPLVFPEVQNSSNYCRNAGGEENRPWCYTM 232
CQ W Q PHQH V PE++NS NYCRN GG +RPWCYT
Sbjct: 529 CQHWNHQVIHFCLCDWKSELGLLLPHQHQLSADVIPELKNSRNYCRNPGGVSDRPWCYTS 588
Query: 233 HPNVRWQYCEIPMCANSSREKDNIKGSNLIMENYFTPTFVLLLSIGGLGCVLAIAGIALL 292
+P+VRW+ C +P C +S Y V++LS L + + L
Sbjct: 589 NPSVRWESCPVPECGETSAASA-----------YSMSVIVIVLS--ALAAAVLFTIVILA 635
Query: 293 CHYIVKNHYSKCNVSSRRNLQNM--DIDLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNII 350
C K ++ V L + ++ LD+L N Y LN KL LE+PRNNI
Sbjct: 636 CRRQRKQWRNRKRVMETPTLSALPSELLLDRLHPNPMYQRVPLLLNSKLLALEYPRNNIQ 695
Query: 351 YIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHP 410
Y+RD+G+GAFGRVFQA+APGL+P E FT+VAVKMLK+EAS D+Q DF+REA L+A FDHP
Sbjct: 696 YVRDIGEGAFGRVFQARAPGLLPMESFTMVAVKMLKEEASADMQNDFQREAALMAQFDHP 755
Query: 411 NIVKLL--------------------GVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSF 450
NIVKLL GVCA+G+PMCL+FEYM GDLNE+LR S S
Sbjct: 756 NIVKLLGASFQAVNYGCGCACVCPLTGVCAVGKPMCLMFEYMAHGDLNEFLRRRSPDQSV 815
Query: 451 APVEHREXXXXXXXX------XXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIND 504
+ I++QIA+GM YLS+RKFVHRDLATRNCL+ +
Sbjct: 816 RTISRASLSGRSFTSELEAGLLSCADQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGE 875
Query: 505 DMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEI 564
+MVVKIADFGLS IY DYYK +E+DAIP+RWMP ESI YN+YT ESD+WAYGV LWEI
Sbjct: 876 EMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDIWAYGVVLWEI 935
Query: 565 FSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQT 624
FS +QPY+GM HEEV+ +++D ++L+CP+N P +Y+LM+ CW+ P +RP+F I++
Sbjct: 936 FSHGMQPYYGMGHEEVIYYVRDGHILSCPENCPLELYNLMRLCWSSQPPERPSFSSIHRI 995
Query: 625 LDNI 628
L+ +
Sbjct: 996 LERM 999
>UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror2 precursor; n=2; Sophophora|Rep:
Tyrosine-protein kinase transmembrane receptor Ror2
precursor - Drosophila melanogaster (Fruit fly)
Length = 724
Score = 450 bits (1110), Expect = e-125
Identities = 204/291 (70%), Positives = 241/291 (82%), Gaps = 8/291 (2%)
Query: 332 GAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASH 391
G + N +LEKLE+PR +I+Y+R LGQGAFGRVFQA+APGL+PD+E LVAVKMLKD+AS
Sbjct: 424 GTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASD 483
Query: 392 DLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACST-VTSF 450
+Q+DFEREACLLA+FDHPNIV+LLGVCA+GRPMCLLFEYM GDL+E+LRACS T
Sbjct: 484 QMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQ 543
Query: 451 APVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKI 510
AP + R +A IA+GMLYLS+RKFVHRDLATRNCLIN+ M VKI
Sbjct: 544 APTQDR-------LQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKI 596
Query: 511 ADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQ 570
ADFGLSHKIYLQDYYKGDE+D IP+RWMPLESILYNK++LESDVWAYG+CLWE+FSFALQ
Sbjct: 597 ADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQ 656
Query: 571 PYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVI 621
PYFG+THEEV++++K+ NVL CPDNTP VY LM++CWN PS+RP F I
Sbjct: 657 PYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEI 707
Score = 320 bits (787), Expect = 5e-86
Identities = 135/283 (47%), Positives = 194/283 (68%), Gaps = 4/283 (1%)
Query: 20 YCGPYNGQVCKSYSTGYVWYN---HTGGLDNEKITSGLWKEMISNLQEPCRTQAERLLCA 76
YC PY+G+VCK Y TG VWY+ TGG NE++T+ LW E+IS+L CR AE++LCA
Sbjct: 69 YCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGLCREAAEKMLCA 128
Query: 77 YAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLPEC 136
YAFP C + G A PLC+EDC A +QFCYNDW++IE++KER +F +SRGHFRLP C
Sbjct: 129 YAFPNCHMEGGRAVKA-PLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNC 187
Query: 137 ENLPHYSGKGSQVSCNNIGITDMDLDQVTTTCVKGNGRYYQGVINETKAGLACQAWESQF 196
+LPHY+ + +C+ IG+T++ +V+ C GNGR+Y G +N +K+G+ CQ W++Q+
Sbjct: 188 SSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQY 247
Query: 197 PHQHTRPPLVFPEVQNSSNYCRNAGGEENRPWCYTMHPNVRWQYCEIPMCANSSREKDNI 256
PH+H +PPLVF ++ NYCRNAGGEE PWCYT+ +VRWQ+C+IPMC +
Sbjct: 248 PHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVD 307
Query: 257 KGSNLIMENYFTPTFVLLLSIGGLGCVLAIAGIALLCHYIVKN 299
+ + ME +FTP+ + LL+ G ++ + + LL + + K+
Sbjct: 308 LNTPIKMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKH 350
>UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=53; Euteleostomi|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Homo sapiens (Human)
Length = 869
Score = 415 bits (1021), Expect = e-114
Identities = 192/315 (60%), Positives = 242/315 (76%), Gaps = 5/315 (1%)
Query: 319 LDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFT 378
LD+L N Y LNPKL LE+PRNNI Y+RD+G+GAFGRVFQA+APGL+P E FT
Sbjct: 545 LDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFT 604
Query: 379 LVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLN 438
+VAVKMLK+EAS D+Q DF+REA L+A+FD+PNIVKLLGVCA+G+PMCLLFEYM GDLN
Sbjct: 605 MVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLN 664
Query: 439 EYLRACS--TVTSFAPVE---HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHR 493
E+LR+ S TV S + + + IARQ+A+GM YLS+RKFVHR
Sbjct: 665 EFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHR 724
Query: 494 DLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESD 553
DLATRNCL+ ++MVVKIADFGLS IY DYYK +E+DAIP+RWMP ESI YN+YT ESD
Sbjct: 725 DLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESD 784
Query: 554 VWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPS 613
VWAYGV LWEIFS+ LQPY+GM HEEV+ +++D N+L+CP+N P +Y+LM+ CW+ P+
Sbjct: 785 VWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPA 844
Query: 614 DRPNFRVIYQTLDNI 628
DRP+F I++ L+ +
Sbjct: 845 DRPSFTSIHRILERM 859
Score = 75.8 bits (178), Expect = 3e-12
Identities = 42/126 (33%), Positives = 64/126 (50%), Gaps = 8/126 (6%)
Query: 20 YCGPYNGQVCKSY-STGYVWYNHTGGLDNEKITSGL----WKEMISNLQEPCRTQAERLL 74
YC Y G+VC + + + + +T D E+ L W E+ + CR AE LL
Sbjct: 316 YCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNEL-KVVSPVCRPAAEALL 374
Query: 75 CAYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLP 134
C + F +C GV +P+C E C+AVK FC +W+V+E++ RG++ +P
Sbjct: 375 CNHIFQEC--SPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVP 432
Query: 135 ECENLP 140
EC LP
Sbjct: 433 ECSKLP 438
>UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane
receptor ROR1 precursor; n=21; Euteleostomi|Rep:
Tyrosine-protein kinase transmembrane receptor ROR1
precursor - Homo sapiens (Human)
Length = 937
Score = 354 bits (871), Expect = 4e-96
Identities = 203/613 (33%), Positives = 315/613 (51%), Gaps = 42/613 (6%)
Query: 20 YCGPYNGQVCKSY---STGYVWYNHTGGLDNEKITSGLWK-EMISNLQEPCRTQAERLLC 75
+C PY G C + T Y+ H G +IT+ S+L + C A LC
Sbjct: 169 FCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLC 228
Query: 76 AYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLPE 135
YAFP C V LC ++C ++ C ++I + +LP
Sbjct: 229 HYAFPYCDETSSVPK-PRDLCRDECEILENVLCQTEYIFARSNPMILM------RLKLPN 281
Query: 136 CENLPHYSGKGSQVSCNNIGITDMDLDQVTTTCVKGNGRYYQGVINETKAGLACQAWESQ 195
CE+LP + +C IGI D C G Y+G ++ TK+G CQ W SQ
Sbjct: 282 CEDLPQPESPEA-ANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQ 340
Query: 196 FPHQHTRPPLVFPEVQNSSNYCRNAGGEENRPWCYTMHPNVRWQYCEIPMC-ANSSREKD 254
+PH HT L FPE+ +YCRN G ++ PWC+T+ N + C+IP C + S+EK+
Sbjct: 341 YPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKN 400
Query: 255 NIKGSNLIMENYFTPTFVLLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSRRNLQN 314
++ +++ + P + LL +C + +N+ + +R ++
Sbjct: 401 KMEILYILVPSVAIPLAIALLFF-------------FIC--VCRNNQKSSSAPVQRQPKH 445
Query: 315 MDIDLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKA--PGLI 372
+ ++ AY PK + E P + + ++ +LG+ AFG++++ PG+
Sbjct: 446 VRGQNVEMSMLNAY-------KPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGM- 497
Query: 373 PDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYM 432
+ LVA+K LKD + +F++EA L+A+ HPNIV LLG +P+C+LFEY+
Sbjct: 498 --DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYI 555
Query: 433 GKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVH 492
+GDL+E+L S + + IA QIA+GM YLS FVH
Sbjct: 556 NQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLH--IAIQIAAGMEYLSSHFFVH 613
Query: 493 RDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLES 552
+DLA RN LI + + VKI+D GLS +IY DYY+ +P+RWMP E+I+Y K++ +S
Sbjct: 614 KDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDS 673
Query: 553 DVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNP 612
D+W++GV LWEIFSF LQPY+G +++EV+ ++ +L C ++ P +Y LM +CWN P
Sbjct: 674 DIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIP 733
Query: 613 SDRPNFRVIYQTL 625
S RP F+ I+ L
Sbjct: 734 SRRPRFKDIHVRL 746
>UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 948
Score = 341 bits (838), Expect = 4e-92
Identities = 209/619 (33%), Positives = 323/619 (52%), Gaps = 39/619 (6%)
Query: 20 YCGPYNGQVCKSYSTG-----YVWYNHT-GGLDNEKITSGLWKEMISNLQEP-CRTQAER 72
YC YN YS G Y+++N + G +D + + + + + P C++ +
Sbjct: 282 YCERYNFNSSVCYSIGEIGIDYIYFNSSVGTVDQYESSLMRLVKAAKDFKVPGCQSVFAQ 341
Query: 73 LLCAYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFR 132
LC +FP+C L +C + C ++ C D I+ ++ F + +
Sbjct: 342 WLCMNSFPQCDLSSSTPR-PLQMCQDQCQSLYTA-CKAD---IDSLQQ---FTLNIAPVK 393
Query: 133 LPECENLPHYSGKGSQ----VSCNNIGITDMDLDQVTTTCVKGN--GRYYQGVINETKAG 186
+C LP +G S S + + TC + G +Y G N T +G
Sbjct: 394 FVDCSLLPKPNGGDSPECFVYSKDQANYYYLQNAPGLQTCYNASDKGIHYNGFANVTASG 453
Query: 187 LACQAWESQFPHQHTRPPLVFPEVQNSSNYCRNAGGEENRPWCYTMHPNVRWQYCEIPMC 246
ACQ W+ PH H ++ P +Q + N+CRN G +RPWCYT+ P++RW+YC++P+C
Sbjct: 454 RACQKWDYTSPHLHPISTVLRPYLQGN-NWCRNPDGRGSRPWCYTVDPSIRWEYCDVPVC 512
Query: 247 ANSSREKDNIKGSNLIMENYFTPTFVLLL----SIGGLGCV---LAIAGIALLCHYIVKN 299
S+ ++ +I+ T V +L I L C L+ ALL IV
Sbjct: 513 QTSTTSLMLVE---IIVPXIVGGTMVFILIPFVCIVILACYTRRLSRKKKALLHLSIVPE 569
Query: 300 HYSKCNVSSRRNLQNMDID-LDKLP-SNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQ 357
+ V + + DID ++ L N+ G P E R+ + Y DLGQ
Sbjct: 570 TVPQAAVEMVK-MSPKDIDGMNPLYCKNIRSSDIGLDGTPLPE---VDRDKVRYEGDLGQ 625
Query: 358 GAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLG 417
G FG V +A A G++P + +VAVK+LK+ AS + +F EA L+ FDHPNIVKL+G
Sbjct: 626 GHFGLVVKATALGVVPGRDQCIVAVKILKEGASLQTKKEFFHEAALMHSFDHPNIVKLIG 685
Query: 418 VCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQ 477
VC P+C++FE+M GDLN +LR S + + ++
Sbjct: 686 VCVEQEPLCMIFEFMQLGDLNNFLRHNSPKWQESSASCAKYGGPKCDITTPIQVA-MSLD 744
Query: 478 IASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRW 537
I +G+ YL+D ++HRDLATRNCL++ D+ +KI+DFGLS IY DY + + + +P+RW
Sbjct: 745 ITAGLAYLADNHYIHRDLATRNCLVSGDLRIKISDFGLSQDIYSTDYCRLSQSELLPIRW 804
Query: 538 MPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTP 597
MP E+IL+ ++T +SDVW+ GV LWE+FS+ +QPY+ M++E+V+ ++D NV+ CPD P
Sbjct: 805 MPPEAILFARFTTQSDVWSLGVVLWELFSYGIQPYYSMSNEQVIAHVRDGNVMNCPDGCP 864
Query: 598 RCVYDLMKQCWNHNPSDRP 616
+YDLM CWN +P RP
Sbjct: 865 SEIYDLMVDCWNMDPGQRP 883
Score = 138 bits (333), Expect = 6e-31
Identities = 75/223 (33%), Positives = 111/223 (49%), Gaps = 11/223 (4%)
Query: 29 CKSYSTGYVWY-NHTGGLDNEKITSGLWKEMISNL---QEPCRTQAERLLCAYAFPKCIN 84
C S +G+V NHT G N+ S I + +PC + LLC YAFP C
Sbjct: 61 CHSTLSGHVVVVNHTRG--NQVQASAFIDRFIVGVLSAPKPCLERVLPLLCFYAFPTCDP 118
Query: 85 KDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLPECENLPHYSG 144
+ + P+C DC ++ +C + W GV G P+C+ + +S
Sbjct: 119 AYDIPVYQ-PICKWDCKIIRDFYCASIWSSFVSYLTAGVL--DLGVLDPPQCDTI-RFSD 174
Query: 145 KGSQVSCNNIGITDMDLDQVTT-TCVKGNGRYYQGVINETKAGLACQAWESQFPHQHTRP 203
G+ C + + +TT +C G GR YQG +N T++GL CQAW Q+PHQH
Sbjct: 175 AGTAPMCISTQDGGPVPEVLTTESCYHGLGRGYQGTMNTTESGLECQAWSEQYPHQHLLT 234
Query: 204 PLVFPEVQNSSNYCRNAGGEENRPWCYTMHPNVRWQYCEIPMC 246
+PE+ + NYCRN G + +PWC+T + RW+YC++P C
Sbjct: 235 TQEYPELIGNENYCRNPGAKGEKPWCFTTNETKRWEYCDVPKC 277
>UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2;
Eumetazoa|Rep: Tyrosine-protein kinase receptor -
Aplysia californica (California sea hare)
Length = 1145
Score = 334 bits (821), Expect = 4e-90
Identities = 174/462 (37%), Positives = 260/462 (56%), Gaps = 41/462 (8%)
Query: 168 CVKGNGRYYQGVINETKAGLACQAWESQFPHQHTRPPLVFPEVQNSSNYCRNAGGEENRP 227
C G G Y+G ++ +K+G C W+ FPE+ NYCRN G E+ P
Sbjct: 422 CYTGRGTNYRGEVSVSKSGFMCLGWKDSG----------FPEL-GDHNYCRNPNGREDAP 470
Query: 228 WCYTMHPNVRWQYCEIPMCAN--SSREKDNIKGSNLIMENYFTPTFVLLLSIGGLGCVLA 285
WC+T + + C +P C++ + +GSN +M P+ + L++G L
Sbjct: 471 WCFTNDRKMPKELCAVPKCSDYDEGHPSEADEGSNKLMY-ILIPSLTVPLALGIL----- 524
Query: 286 IAGIALLCHYIVKNHYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQLNPKLEKL--E 343
+AL+C + K+H ++ + + + Q +++ + LNPK E
Sbjct: 525 ---LALIC-FCQKSHNTRASRPNNKQAQPVEM---------------SPLNPKSASRARE 565
Query: 344 FPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACL 403
FP NI ++++LG+GAFG+V++ + GL + T VA+K LK+ A +Q DF RE L
Sbjct: 566 FPMPNIRFLQELGEGAFGKVYKGELVGLYGESSVTTVAIKTLKENALPKVQNDFRREVDL 625
Query: 404 LADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXX 463
++D HPNIV LLGVC PMC+LFEYM +GDL+EYL + S + E +
Sbjct: 626 MSDMRHPNIVCLLGVCMKQEPMCMLFEYMAQGDLHEYLLSHSPHSDVTAAED-DSGTGGG 684
Query: 464 XXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQD 523
++ Q+A+GM YL+ FVHRDLA RN L+ D + VKI+DFGLS +Y D
Sbjct: 685 HILEYSEMLHVSTQVAAGMEYLASHHFVHRDLAARNILVADGLTVKISDFGLSRDVYSSD 744
Query: 524 YYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRF 583
YY+ +PVRWMP E+ILY K+T +SDVWA+GV LWE+FS+ LQPY+G +++EV+
Sbjct: 745 YYRVQSKSLLPVRWMPPEAILYGKFTTDSDVWAFGVVLWEVFSYGLQPYYGFSNQEVIEM 804
Query: 584 LKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
++ +L CP+ P +Y LM +CW+ P+ RP FR I+ L
Sbjct: 805 IRSRQILGCPEECPARIYGLMVECWHEMPARRPPFREIHTRL 846
Score = 35.1 bits (77), Expect = 5.8
Identities = 22/99 (22%), Positives = 43/99 (43%), Gaps = 5/99 (5%)
Query: 20 YCGPYNGQVCKSYSTG---YVWYNHTGGLDNEKITSGLWK-EMISNLQEPCRTQAERLLC 75
+C Y G C + YV T EK + + S++ + C+ + LC
Sbjct: 234 FCQIYRGSTCAKFVGNMSIYVTSKLTQSRAEEKYMAAFAVIQASSHMSQRCQQYGIQSLC 293
Query: 76 AYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIV 114
+AFP C +K +C ++C+A++ C ++++
Sbjct: 294 YHAFPLC-DKTADRPTPRKICRDECLALENDICRTEYLM 331
>UniRef50_Q01974 Cluster: Tyrosine-protein kinase transmembrane
receptor ROR2 precursor; n=36; Euteleostomi|Rep:
Tyrosine-protein kinase transmembrane receptor ROR2
precursor - Homo sapiens (Human)
Length = 943
Score = 328 bits (806), Expect = 3e-88
Identities = 201/610 (32%), Positives = 301/610 (49%), Gaps = 40/610 (6%)
Query: 20 YCGPYNGQVCKSY---STGYVWYNHTGGLDNEKITSGLWKEMIS-NLQEPCRTQAERLLC 75
+C PY G C + T YV G +IT+ S +L + C A C
Sbjct: 173 FCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFC 232
Query: 76 AYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLPE 135
+ FP C + LC ++C ++ C ++ + R +LP+
Sbjct: 233 HFVFPLCDARSRTPK-PRELCRDECEVLESDLCRQEYTIARSNP----LILMR--LQLPK 285
Query: 136 CENLPHYSGKGSQVSCNNIGITDMDLDQVTTTCVKGNGRYYQGVINETKAGLACQAWESQ 195
CE LP + +C IGI L + C G+G Y+G + TK+G CQ W Q
Sbjct: 286 CEALPMPESPDA-ANCMRIGIPAERLGRYHQ-CYNGSGMDYRGTASTTKSGHQCQPWALQ 343
Query: 196 FPHQHTRPPLVFPEVQNSSNYCRNAGGEENRPWCYTMHPNVRWQYCEIPMCANSSREKDN 255
PH H FPE+ YCRN GG+ PWC+T + NVR + C++P C+ K
Sbjct: 344 HPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMG 403
Query: 256 IKGSNLIMENYFTPTFVLLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSRRNLQNM 315
I ++L+ SI + V+A L+C + +N K + S+ + Q M
Sbjct: 404 I-------------LYILVPSIA-IPLVIACL-FFLVC--MCRNK-QKASASTPQRRQLM 445
Query: 316 DIDLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDE 375
+ L A+L E + + ++ +LG+ FG+V++ G P E
Sbjct: 446 ASPSQDMEMPLINQHKQAKLK------EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGE 499
Query: 376 EFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKG 435
+ VA+K LKD+A L+ +F EA L A HPN+V LLGV +P+ ++F Y G
Sbjct: 500 QTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHG 559
Query: 436 DLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDL 495
DL+E+L S + V + + QIA+GM YLS VH+DL
Sbjct: 560 DLHEFLVMRSP---HSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDL 616
Query: 496 ATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVW 555
ATRN L+ D + VKI+D GL ++Y DYYK + +P+RWM E+I+Y K++++SD+W
Sbjct: 617 ATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIW 676
Query: 556 AYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDR 615
+YGV LWE+FS+ LQPY G ++++VV +++ VL CPD+ P VY LM +CWN PS R
Sbjct: 677 SYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRR 736
Query: 616 PNFRVIYQTL 625
P F+ I+ L
Sbjct: 737 PRFKDIHSRL 746
>UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror precursor; n=1; Drosophila
melanogaster|Rep: Tyrosine-protein kinase transmembrane
receptor Ror precursor - Drosophila melanogaster (Fruit
fly)
Length = 685
Score = 305 bits (750), Expect = 2e-81
Identities = 184/533 (34%), Positives = 277/533 (51%), Gaps = 43/533 (8%)
Query: 95 LCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLPECENLPHYSGKGSQVSCNNI 154
+C E+C ++ + C ++ + K V G + +C+ LP + C ++
Sbjct: 179 ICREECELLENELCQKEYAIA---KRHPVI----GMVGVEDCQKLPQHK------DCLSL 225
Query: 155 GITDMDLDQVTTTCVKGNGRYYQGVINETKAGLACQAWESQFPHQHTRPPLVFPEVQNSS 214
GIT +++D+ T C +G Y+GV N + +G C W P L+
Sbjct: 226 GIT-IEVDK-TENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELI------GQ 277
Query: 215 NYCRNAGGEENRPWCYTMHPNVRW-QYCEIPMCANSSREKDNIKGSNLIMENYFTPTFVL 273
NYCRN G EN PWC+ R + C+IP CA+ I G+ + F F +
Sbjct: 278 NYCRNPGSVENSPWCFVDSSRERIIELCDIPKCADKIWIA--IVGTTAAIILIFIIIFAI 335
Query: 274 LLSIGGLGCVLAIAGIALL-CHYIVKNHYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTTG 332
+L + I + KN Y +++ ++ + L L ++A ++
Sbjct: 336 ILFKRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGN--LGNLSDHVALNSKL 393
Query: 333 AQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHD 392
+ N L F ++ ++ +LG+GAFG+V++ + L P++ VA+K LK+ AS
Sbjct: 394 IERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAIKALKENASVK 451
Query: 393 LQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAP 452
Q DF+RE L++D H NIV +LGV P C+LFEYM GDL+E+L S +P
Sbjct: 452 TQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFL------ISNSP 505
Query: 453 VEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIAD 512
E + IA QI+ GM YLS +VHRDLA RNCL+N+ +VVKI+D
Sbjct: 506 TEGKSLSQLEFLQ--------IALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISD 557
Query: 513 FGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY 572
FGLS IY DYY+ +PVRWMP ESILY K+T ESDVW++GV LWEI+S+ +QPY
Sbjct: 558 FGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPY 617
Query: 573 FGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+G +++EV+ ++ +L+ P+N P VY LM +CW+ RP F I L
Sbjct: 618 YGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDISNRL 670
>UniRef50_Q4R1V1 Cluster: Neurospecific receptor kinase; n=1;
Daphnia magna|Rep: Neurospecific receptor kinase -
Daphnia magna
Length = 685
Score = 300 bits (736), Expect = 8e-80
Identities = 153/339 (45%), Positives = 207/339 (61%), Gaps = 33/339 (9%)
Query: 20 YCGPYNGQVCKSY--STGYVWYN-----HTGGLDNEKITSGLWKEMISNLQEPCRTQAER 72
YCG Y G +C+ + VWYN TGG NE++ GLW+E+++ L+EPC++ A++
Sbjct: 357 YCGRYTGNICRGQLSNPASVWYNISSNDQTGGWLNEQLVHGLWEEVVNTLREPCKSAAKK 416
Query: 73 LLCAYAFPKC-INKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHF 131
LLC YAFP+C +++DG LPLCYEDCMA + FC +DW +E K+RG + SRGHF
Sbjct: 417 LLCLYAFPECHLDEDGFAR-KLPLCYEDCMATRQLFCVDDWAQLESNKQRGFYLGSRGHF 475
Query: 132 RLPECENLPHYSGK---------GSQV-----SCNNIGITDMDLDQVTTTCVKGNGRYYQ 177
RLP+CE LP + GS+ SC+ +T + +VTT+C+KG GR+YQ
Sbjct: 476 RLPKCEKLPRIGSRSFFMSSSHGGSKYGQDPPSCSRGHLTQLVPAEVTTSCIKGRGRFYQ 535
Query: 178 GVINETKAGLACQAWESQFPHQHTRPPL-VFPEVQNSSNYCRNAGGEENRPWCYTMHPNV 236
G ++ T+ G+ACQ W++Q PH H RPPL +FPE+Q + N+CRNAGGEE RPWCYT P V
Sbjct: 536 GNVSVTRDGIACQRWDAQEPHSHNRPPLNIFPEMQGAENFCRNAGGEEPRPWCYTTDPLV 595
Query: 237 RWQYCEIPMCANSSREKDNIKGSNLIMENYFTPTFVLLLSIGGLGCVLAIAGIALLCHYI 296
RWQ C+IP C +S ++ + L ME FTP FVLLL+ G +L LLC
Sbjct: 596 RWQPCDIPQCGHS-----EVEVTLLPMEATFTPGFVLLLAGVGFLSLLIFLLFLLLCQRA 650
Query: 297 VKNHYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQL 335
+K H + S LQ IDL KL N Y GA++
Sbjct: 651 LK-HKQGYQLPS---LQKESIDLQKLRDNSTYQCVGARI 685
>UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3;
Endopterygota|Rep: Tyrosine-protein kinase receptor -
Anopheles gambiae str. PEST
Length = 646
Score = 296 bits (726), Expect = 1e-78
Identities = 183/527 (34%), Positives = 271/527 (51%), Gaps = 44/527 (8%)
Query: 95 LCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLPECENLPHYSGKGSQVSCNNI 154
+C DC ++ + C ++ + + G L EC++LP Q SC +
Sbjct: 142 ICRNDCELLENELCQKEYAIAKRHPTIGQ------KLPLEECDDLP------LQKSCMRL 189
Query: 155 GITDMDLDQVTTTCVKGNGRYYQGVINETKAGLACQAWESQFPHQHTRPPLVFPEVQNSS 214
GI D+D+ + C NG Y+G+++ TK+ C W S+ H + FP +
Sbjct: 190 GI-DLDI-KPNDDCYWENGASYRGIMDRTKSSKICMRW-SKLMHTMSE----FPHLAGH- 241
Query: 215 NYCRNA--GGEENRPWCYT-MHPNVRWQYCEIPMCANSSREKDNIKGSNLIMENYFTPTF 271
NYCRN G + PWCY M + +YC+IP C+ I G ++ F
Sbjct: 242 NYCRNPPHAGPMDAPWCYVDMQKTI--EYCDIPKCSERMWMYIII-GFVAVISPLFIGIG 298
Query: 272 VLLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTT 331
V V I I L KN Y ++S + ++ + +
Sbjct: 299 VFCCRKYRKHGVSNIQNINL--PNADKNIYGNSRLNSPIEMTSLIANQSSTGAASRNAEN 356
Query: 332 GAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASH 391
G++ N ++ ++ ++ +LG+GAFG+V++ + + E VAVK LK+ AS
Sbjct: 357 GSRNNGISRVPQYTLQDVRFVEELGEGAFGKVYKGELTQ--KNGERIFVAVKALKENASA 414
Query: 392 DLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFA 451
Q DF+RE L++D H NIV +LGV P+C+LFEYM +GDL+E+L A S
Sbjct: 415 KTQADFKREIELISDLKHDNIVCILGVVLKEEPLCMLFEYMAQGDLHEFLIANS------ 468
Query: 452 PVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIA 511
P E + IA+QI GM YL+ +VHRDLA RNCL+ D++ VKI+
Sbjct: 469 PNEGKSLSQLQFLL--------IAQQICDGMEYLASHHYVHRDLAARNCLVGDNLTVKIS 520
Query: 512 DFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQP 571
DFGLS IY DYY+ +PVRWMP ESILY K+T ESDVW++GV LWEI+S+ LQP
Sbjct: 521 DFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGLQP 580
Query: 572 YFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
Y+G +++EV+ ++ +L CP++ P VY LM +CW+ RP F
Sbjct: 581 YYGYSNQEVINMVRARQLLPCPESCPSAVYSLMVECWHEQAVRRPTF 627
>UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle
specific tyrosine kinase receptor; n=1;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
muscle specific tyrosine kinase receptor -
Strongylocentrotus purpuratus
Length = 827
Score = 284 bits (696), Expect = 6e-75
Identities = 150/373 (40%), Positives = 217/373 (58%), Gaps = 13/373 (3%)
Query: 258 GSNLIMENYFTPTFVLLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSRRNLQNMDI 317
G + E+ P L+L I ++ + G++ + + + HY +N I
Sbjct: 454 GGKPVDESEQEPYLFLILVITIPSSIVVLIGVSAIAYGV--RHYRNSKFPLPKN-----I 506
Query: 318 DLDKLPSNLAYHTT-GAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEE 376
DL L NL Y NP+L LE+ RNN+IY +D+G+GAFGRVF A AP L+ E
Sbjct: 507 DLKDLTENLMYGKNFNTSFNPQLAYLEYNRNNVIYEKDIGEGAFGRVFMASAPKLVAGEA 566
Query: 377 FTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGD 436
T VAVKMLK A + F REA ++A F H NIVKLLGVC +GRP+CLL EYM +GD
Sbjct: 567 ETSVAVKMLKATADKVVTEYFNREAQMIARFSHQNIVKLLGVCFVGRPLCLLLEYMSEGD 626
Query: 437 LNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLA 496
L +YL + S S + +A+QIA GM YL++ FVHRD+A
Sbjct: 627 LEDYLHSRSPHRS-----NSRTSNSPGSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIA 681
Query: 497 TRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWA 556
TRNCLIN VKI+DFGL+ + ++ + G + + IP+RW E++ ++T SDVW+
Sbjct: 682 TRNCLINSRTDVKISDFGLARYVGHKECFVGHKEEHIPIRWTAPEALWDYQFTYASDVWS 741
Query: 557 YGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRP 616
+GV LWE+FS+A QPY ++HE+V + L+ +NTP+ V+ +M +CW NP+DRP
Sbjct: 742 FGVLLWELFSYAEQPYLNLSHEDVFLHTRQGYRLSSLENTPQKVHQIMGECWQANPADRP 801
Query: 617 NFRVIYQTLDNIQ 629
F+ + +L +++
Sbjct: 802 FFKQLQDSLASME 814
Score = 44.0 bits (99), Expect = 0.013
Identities = 38/128 (29%), Positives = 57/128 (44%), Gaps = 12/128 (9%)
Query: 20 YCGPYNGQVCKSY---STGYVWYNHTG----GLDNEKITSGLWKEMISNLQEPCRTQAER 72
YC YNG C + S Y++ N G LDN K++ L + ++++ E C+
Sbjct: 284 YCAAYNGATCHNQLPSSPYYIFVNGHGDEPLALDN-KLSEILSSKTMTSMPEDCQAGIRE 342
Query: 73 LLCAYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFR 132
LLC PKC G +C EDC V+ C +W + ++ + + R
Sbjct: 343 LLCHATHPKC-QVVGQKPRGQKICKEDCEIVQ-SMC-PEWAQLVNRFLDPLPDKIRS-LG 398
Query: 133 LPECENLP 140
L CENLP
Sbjct: 399 LSSCENLP 406
>UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2;
Branchiostoma floridae|Rep: Tyrosine-protein kinase
receptor - Branchiostoma floridae (Florida lancelet)
(Amphioxus)
Length = 797
Score = 272 bits (668), Expect = 1e-71
Identities = 131/283 (46%), Positives = 178/283 (62%), Gaps = 11/283 (3%)
Query: 346 RNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLA 405
R+ I ++ +LG+GAFGRV+ K L PDE+ +LVAVK LK+ + D + DF+REA LL
Sbjct: 507 RDTIHFVGELGEGAFGRVYLGKCEKLKPDEDASLVAVKTLKEMSVEDARKDFDREAELLT 566
Query: 406 DFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFA---PVEHREXXXXX 462
+ H NIVK GVC G P ++FEYM GDLN YLR+ +F P H+E
Sbjct: 567 NMQHENIVKFYGVCTEGEPWLMIFEYMENGDLNNYLRSHGPDAAFLIKNPATHKELSIVE 626
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ 522
I+ Q+ASG+ Y++ + FVHRDLATRNCL+ D +VVKI DFG+S IY
Sbjct: 627 LLQ--------ISVQVASGVEYMASQHFVHRDLATRNCLVGDKLVVKIGDFGMSRDIYST 678
Query: 523 DYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVR 582
DYY+ H +PVRWMP ES+LY K+T+ESD+W++GV LWEIF+F QP++ + + EV+
Sbjct: 679 DYYRVGGHTMLPVRWMPPESVLYRKFTIESDIWSFGVVLWEIFTFGKQPWYELANHEVIE 738
Query: 583 FLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+ +L CP PR V LM CW P+ R N + I++ L
Sbjct: 739 CITSGRLLGCPRGCPRNVRALMLGCWKKTPAQRTNIQDIHKKL 781
>UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=17; Euteleostomi|Rep: BDNF/NT-3 growth
factors receptor precursor - Gallus gallus (Chicken)
Length = 818
Score = 272 bits (666), Expect = 2e-71
Identities = 139/315 (44%), Positives = 192/315 (60%), Gaps = 10/315 (3%)
Query: 317 IDLDKLP--SNLAYH-TTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIP 373
I + K+P N Y T +QL P R+NI+ R+LG+GAFG+VF A+ L P
Sbjct: 499 IGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCP 558
Query: 374 DEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMG 433
+++ LVAVK LKD AS + + DF REA LL + H +IVK GVC G P+ ++FEYM
Sbjct: 559 EQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMK 617
Query: 434 KGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHR 493
GDLN++LRA +R IA+QIA+GM+YL+ + FVHR
Sbjct: 618 HGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLH------IAQQIAAGMVYLASQHFVHR 671
Query: 494 DLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESD 553
DLATRNCL+ ++++VKI DFG+S +Y DYY+ H +P+RWMP ESI+Y K+T ESD
Sbjct: 672 DLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESD 731
Query: 554 VWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPS 613
VW+ GV LWEIF++ QP++ +++ EV+ + VL P P+ VYDLM CW P
Sbjct: 732 VWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPH 791
Query: 614 DRPNFRVIYQTLDNI 628
R N + I+ L N+
Sbjct: 792 MRLNIKEIHSLLQNL 806
>UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=73; Gnathostomata|Rep: BDNF/NT-3 growth
factors receptor precursor - Homo sapiens (Human)
Length = 822
Score = 269 bits (659), Expect = 2e-70
Identities = 138/315 (43%), Positives = 191/315 (60%), Gaps = 10/315 (3%)
Query: 317 IDLDKLP--SNLAYH-TTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIP 373
I + K+P N Y T +QL P R+NI+ R+LG+GAFG+VF A+ L P
Sbjct: 503 IGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCP 562
Query: 374 DEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMG 433
+++ LVAVK LKD AS + + DF REA LL + H +IVK GVC G P+ ++FEYM
Sbjct: 563 EQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMK 621
Query: 434 KGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHR 493
GDLN++LRA P IA+QIA+GM+YL+ + FVHR
Sbjct: 622 HGDLNKFLRA------HGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHR 675
Query: 494 DLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESD 553
DLATRNCL+ ++++VKI DFG+S +Y DYY+ H +P+RWMP ESI+Y K+T ESD
Sbjct: 676 DLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESD 735
Query: 554 VWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPS 613
VW+ GV LWEIF++ QP++ +++ EV+ + VL P P+ VY+LM CW P
Sbjct: 736 VWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPH 795
Query: 614 DRPNFRVIYQTLDNI 628
R N + I+ L N+
Sbjct: 796 MRKNIKGIHTLLQNL 810
>UniRef50_O76997 Cluster: Putative neurotrophin receptor LTRK 1
precursor; n=2; Lymnaea stagnalis|Rep: Putative
neurotrophin receptor LTRK 1 precursor - Lymnaea
stagnalis (Great pond snail)
Length = 794
Score = 246 bits (601), Expect = 2e-63
Identities = 123/278 (44%), Positives = 166/278 (59%), Gaps = 3/278 (1%)
Query: 349 IIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFD 408
I+ +R +G+GAFGRVF LI EF +VAVK LK S L+ DFEREA +LA +
Sbjct: 504 ILLMRVIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDSLKRDFEREAEMLATIE 563
Query: 409 HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXX 468
H NIV GVC ++FE+M GDLN+YLR +F ++ R+
Sbjct: 564 HANIVTFYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDAAF--LKDRDSMDSDEGQLTR 621
Query: 469 XXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGD 528
I QIAS M YL+ + FVHRDLATRNCL+ D+VVK+ DFG+S +Y DYY+ +
Sbjct: 622 EQLMKIVLQIASAMEYLALQHFVHRDLATRNCLVGCDLVVKLGDFGMSRDVYTTDYYRVE 681
Query: 529 EHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDEN 588
+PVRWMP ESI+Y +T ESDVW++GV LWE+F++ QP+F ++ EV+ +K+
Sbjct: 682 GTAMLPVRWMPPESIIYRTFTTESDVWSFGVTLWEVFTYGKQPWFEYSNSEVIEHIKNSR 741
Query: 589 VLACPDNT-PRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
L P T VY +M+ CW NP DR + I + L
Sbjct: 742 TLKRPPRTCTDGVYRVMQGCWKPNPQDRLTMKDIAELL 779
>UniRef50_Q16288 Cluster: NT-3 growth factor receptor precursor;
n=49; Euteleostomi|Rep: NT-3 growth factor receptor
precursor - Homo sapiens (Human)
Length = 839
Score = 244 bits (597), Expect = 6e-63
Identities = 129/294 (43%), Positives = 179/294 (60%), Gaps = 18/294 (6%)
Query: 346 RNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLA 405
R +I+ R+LG+GAFG+VF A+ L P ++ LVAVK LKD + DF+REA LL
Sbjct: 535 RRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLA-ARKDFQREAELLT 593
Query: 406 DFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXX 465
+ H +IVK GVC G P+ ++FEYM GDLN++LRA + V+ +
Sbjct: 594 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP-DAMILVDGQP--RQAKGE 650
Query: 466 XXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYY 525
IA QIASGM+YL+ + FVHRDLATRNCL+ +++VKI DFG+S +Y DYY
Sbjct: 651 LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYY 710
Query: 526 K-----GDE---------HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQP 571
+ G++ H +P+RWMP ESI+Y K+T ESDVW++GV LWEIF++ QP
Sbjct: 711 RLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 770
Query: 572 YFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+F +++ EV+ + VL P P+ VYD+M CW P R N + IY+ L
Sbjct: 771 WFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL 824
>UniRef50_P04629 Cluster: High affinity nerve growth factor receptor
precursor; n=28; Eumetazoa|Rep: High affinity nerve
growth factor receptor precursor - Homo sapiens (Human)
Length = 796
Score = 241 bits (589), Expect = 5e-62
Identities = 119/280 (42%), Positives = 167/280 (59%), Gaps = 5/280 (1%)
Query: 346 RNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLA 405
R +I+ +LG+GAFG+VF A+ L+P+++ LVAVK LK EAS + DF+REA LL
Sbjct: 507 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAELLT 565
Query: 406 DFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXX 465
H +IV+ GVC GRP+ ++FEYM GDLN +LR+
Sbjct: 566 MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLA----GGEDVAPGP 621
Query: 466 XXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYY 525
+A Q+A+GM+YL+ FVHRDLATRNCL+ +VVKI DFG+S IY DYY
Sbjct: 622 LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYY 681
Query: 526 KGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLK 585
+ +P+RWMP ESILY K+T ESDVW++GV LWEIF++ QP++ +++ E + +
Sbjct: 682 RVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT 741
Query: 586 DENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
L P P VY +M+ CW P R + + ++ L
Sbjct: 742 QGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 781
>UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=25;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] -
Xenopus laevis (African clawed frog)
Length = 1358
Score = 237 bits (580), Expect = 7e-61
Identities = 123/322 (38%), Positives = 182/322 (56%), Gaps = 11/322 (3%)
Query: 304 CNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRV 363
C V +RN + + N Y + P +K E PR I R+LGQG+FG V
Sbjct: 952 CFVFKKRNSNRLGNGVLYASVNPEYFSAAEMYVP--DKWEVPREKITMNRELGQGSFGMV 1009
Query: 364 FQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGR 423
++ A G++ DE T VA+K + + AS +++F EA ++ +F+ ++V+LLGV + G+
Sbjct: 1010 YEGIAKGVVKDEAETKVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQ 1069
Query: 424 PMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGML 483
P ++ E M +GDL YLR+ T +A +IA GM
Sbjct: 1070 PTLVIMELMTRGDLKSYLRSLRPDTE---------SNSGQPTPSLKKMIQMAGEIADGMS 1120
Query: 484 YLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESI 543
YL+ KFVHRDLA RNC++ +D VKI DFG++ IY DYY+ +PVRWM ES+
Sbjct: 1121 YLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESL 1180
Query: 544 LYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDL 603
+T SDVW++GV LWEI + A QPY GM++E+V+RF+ + +L PDN P +++L
Sbjct: 1181 KDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLEKPDNCPDMLFEL 1240
Query: 604 MKQCWNHNPSDRPNFRVIYQTL 625
M+ CW NP RP+F I ++
Sbjct: 1241 MRMCWQFNPKMRPSFLEIISSI 1262
>UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=47;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] - Homo
sapiens (Human)
Length = 1367
Score = 231 bits (565), Expect = 4e-59
Identities = 114/286 (39%), Positives = 172/286 (60%), Gaps = 9/286 (3%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E R I R+LGQG+FG V++ A G++ DE T VA+K + + AS +++F
Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ +F+ ++V+LLGV + G+P ++ E M +GDL YLR+ PV
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPV------ 1103
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+A +IA GM YL+ KFVHRDLA RNC++ +D VKI DFG++ I
Sbjct: 1104 ---LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI 1160
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ +PVRWM ES+ +T SDVW++GV LWEI + A QPY G+++E+
Sbjct: 1161 YETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQ 1220
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
V+RF+ + +L PDN P +++LM+ CW +NP RP+F I ++
Sbjct: 1221 VLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
>UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin
receptor; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to insulin receptor - Tribolium castaneum
Length = 1351
Score = 223 bits (546), Expect = 9e-57
Identities = 113/279 (40%), Positives = 165/279 (59%), Gaps = 7/279 (2%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E PR I IR+LGQG+FG V++ A + + AVK + + A++ +L+F
Sbjct: 971 DEWEVPRKKIELIRELGQGSFGMVYEGIAQDVRGKAQIKC-AVKTVNEHATNRERLEFLN 1029
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ FD ++V+LLGV + G+P ++ E M GDL YLR S P
Sbjct: 1030 EASVMKAFDTAHVVRLLGVVSQGQPTLVIMELMANGDLKTYLR------SHRPDAEVYDP 1083
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+A +IA GM YLS +KFVHRDLA RNC++ +D+ VKI DFG++ I
Sbjct: 1084 ATAKQPPTLKQILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDI 1143
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ +PVRWM ES+ +T SDVW+YGV LWE+ + A QPY G+++++
Sbjct: 1144 YETDYYRKGTKGLLPVRWMAPESLKDGVFTSNSDVWSYGVVLWEMATLASQPYQGLSNDQ 1203
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
V+R++ D V+ P+N P +Y LM+ CW H PS RP+F
Sbjct: 1204 VLRYVIDGGVMERPENCPDKLYTLMRYCWQHKPSARPSF 1242
>UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor (EC
2.7.10.1) (ILP receptor) [Contains: Insulin-like peptide
receptor alpha chain; Insulin-like peptide receptor beta
chain]; n=4; Eukaryota|Rep: Insulin-like peptide receptor
precursor (EC 2.7.10.1) (ILP receptor) [Contains:
Insulin-like peptide receptor alpha chain; Insulin-like
peptide receptor beta chain] - Branchiostoma lanceolatum
(Common lancelet) (Amphioxus)
Length = 1363
Score = 223 bits (546), Expect = 9e-57
Identities = 117/295 (39%), Positives = 168/295 (56%), Gaps = 9/295 (3%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E PR I IR+LGQG+FG V++ +A ++ DE VAVK + + AS +++F
Sbjct: 985 DEWEVPREKITLIRELGQGSFGMVYEGEAKDVVKDEPMVSVAVKTVNESASIRERIEFLN 1044
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRAC----STVTSFAPVEH 455
EA ++ F+ ++VKL+GV + G+P ++ E M GDL YLR S +P +
Sbjct: 1045 EASVMKTFNCHHVVKLMGVVSKGQPTLVVMELMALGDLKNYLRRHRPEEDVGLSDSPASN 1104
Query: 456 REXXXXXXXXX-----XXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKI 510
+A IA GM YL+ +KFVHRDLA RNC++ D VKI
Sbjct: 1105 EAKNSPFAENDNDLPPTFKDIIQMAGVIADGMSYLAAKKFVHRDLACRNCMVAQDRTVKI 1164
Query: 511 ADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQ 570
DFG++ IY DYY+ +PVRWM ES+ +T +SDVW+YGV LWE+ + A Q
Sbjct: 1165 GDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKVGVFTSQSDVWSYGVVLWEMATLASQ 1224
Query: 571 PYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
PY G ++EEV++F+ D +L P+ P +YDLMK CW + S RP F I + L
Sbjct: 1225 PYQGKSNEEVLKFVIDGGMLEKPEGCPNKLYDLMKLCWQYRQSMRPTFLEIVEIL 1279
>UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor); n=1; Apis
mellifera|Rep: PREDICTED: similar to Insulin-like growth
factor 1 receptor precursor (Insulin-like growth factor
I receptor) (IGF-I receptor) - Apis mellifera
Length = 855
Score = 223 bits (544), Expect = 2e-56
Identities = 111/287 (38%), Positives = 166/287 (57%), Gaps = 11/287 (3%)
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
L++ E PR I +R LG G FG V++ A ++ + AVK + +A+ +++F
Sbjct: 320 LDEWEVPREKIEMLRSLGTGTFGMVYEGIAKDIVKGKSEVRCAVKTVNKDATDRERIEFL 379
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
EA ++ FD ++VKLLGV G+P ++ E M GDL YLR+ HR
Sbjct: 380 NEASVMKGFDAHHVVKLLGVVTRGQPTLVIMELMVNGDLKRYLRS-----------HRPC 428
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
+A +IA GM YLS +KFVHRDLA RNC++ +D+ VK+ DFG++
Sbjct: 429 ENMSNAPPKLDRILQMAIEIADGMAYLSTKKFVHRDLAARNCMVAEDLTVKVGDFGMTRD 488
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
IY +DYY+ +PVRWM ES+ ++ SDVW+YGV LWE+ +FA QPY G+++E
Sbjct: 489 IYERDYYRKGSKGLLPVRWMAPESLKDGVFSSYSDVWSYGVVLWEMVTFASQPYQGLSNE 548
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+V+R++ + V+ P+N P +Y+LMK+ W H + RP F I L
Sbjct: 549 QVLRYVIEGGVMERPENCPELLYELMKRTWRHKATRRPTFMDIASML 595
>UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 822
Score = 223 bits (544), Expect = 2e-56
Identities = 119/296 (40%), Positives = 168/296 (56%), Gaps = 17/296 (5%)
Query: 346 RNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDE-------ASHDLQLDFE 398
R+NII R+LG+GAFG+VF A+ L PD+E VAVK+ S + E
Sbjct: 519 RHNIILKRELGEGAFGKVFLAECYNLTPDQEKIHVAVKVGTGRFSPPSLPPSDPERSQRE 578
Query: 399 REACLLA------DFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAP 452
+ LL H +IV GVC P+ ++FEYM GDLN++LR+
Sbjct: 579 QPGGLLPGGRAPHQLQHEHIVTFYGVCVESDPLIMVFEYMKHGDLNKFLRSHGPDAVLIV 638
Query: 453 VEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIAD 512
+ IA+QIA+GM+YL+ + FVHRDLATRNCL+ ++++VKI D
Sbjct: 639 ----DGQHSIPVELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGD 694
Query: 513 FGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY 572
FG+S +Y DYY+ H +P+RWMP ESI+Y ++T ESDVW+ GV LWEIF++ QP+
Sbjct: 695 FGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPW 754
Query: 573 FGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ +++ EV+ + VL P P+ VYDLM CW+ P R N + IY L +
Sbjct: 755 YQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWHREPYMRLNIKEIYGMLQGL 810
>UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;
Aplysia californica|Rep: Trk-like receptor tyrosine
kinase - Aplysia californica (California sea hare)
Length = 865
Score = 223 bits (544), Expect = 2e-56
Identities = 141/362 (38%), Positives = 195/362 (53%), Gaps = 24/362 (6%)
Query: 268 TP-TFVLLLSIGG-LGCVLAIAGIALLCH--YIVKNHYSKCNVSSR-RNLQNMDI--DLD 320
TP T ++ IG L CV+ + +A+LC + K SK N + RN + ++
Sbjct: 208 TPITHIVAPVIGSVLVCVILVV-VAVLCRRRQVRKKLCSKRNGDNIVRNTDGALLLERMN 266
Query: 321 KLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLV 380
+ N Y + + E P + + I +G+GAFG+VF+ + V
Sbjct: 267 NINKNPTYFSPSGASARRHAVQEVPADCLTLIEVVGEGAFGQVFRGELRSA-EGGACHQV 325
Query: 381 AVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMC--LLFEYMGKGDLN 438
AVK+LKD AS D DFERE +++ FDH NI+KLLG+ G ++FEYM GDL+
Sbjct: 326 AVKVLKDGASPDAHEDFEREVEIMSAFDHDNILKLLGIVVQGVEGAPYMVFEYMEHGDLS 385
Query: 439 EYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATR 498
E LR H I+ QIA+GM YL+ ++FVHRDLATR
Sbjct: 386 ELLRRNDP--------HLRSADSKTFRLNKSDLVEISVQIATGMRYLAAQRFVHRDLATR 437
Query: 499 NCLIND-----DMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESD 553
NCL+ ++VKI+DFG+S IY DYYK +P+RWM E+I Y ++T ESD
Sbjct: 438 NCLVGTAPPGAGLLVKISDFGMSRDIYTNDYYKIGGSRMLPIRWMSPEAIKYGRFTCESD 497
Query: 554 VWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPS 613
VWAYGV LWEIFS+ QPYFG ++EEV+ FL +L P++ P VY +M CW +P
Sbjct: 498 VWAYGVVLWEIFSYGRQPYFGHSNEEVIHFLDQGILLQRPEDCPSTVYHVMLGCWKGDPR 557
Query: 614 DR 615
R
Sbjct: 558 QR 559
>UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (CD220 antigen) [Contains: Insulin receptor subunit
alpha; Insulin receptor subunit beta]; n=100;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Homo sapiens (Human)
Length = 1382
Score = 223 bits (544), Expect = 2e-56
Identities = 116/286 (40%), Positives = 162/286 (56%), Gaps = 9/286 (3%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E R I +R+LGQG+FG V++ A +I E T VAVK + + AS +++F
Sbjct: 1014 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1073
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ F ++V+LLGV + G+P ++ E M GDL YLR+ P
Sbjct: 1074 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 1133
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+A +IA GM YL+ +KFVHRDLA RNC++ D VKI DFG++ I
Sbjct: 1134 QEMIQ---------MAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI 1184
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ +PVRWM ES+ +T SD+W++GV LWEI S A QPY G+++E+
Sbjct: 1185 YETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQ 1244
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
V++F+ D L PDN P V DLM+ CW NP RP F I L
Sbjct: 1245 VLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290
>UniRef50_Q25410 Cluster: Putative molluscan insulin-related
peptide(s) receptor precursor (EC 2.7.10.1) [Contains:
Putative molluscan insulin-related peptide(s) receptor
alpha chain; Putative molluscan insulin-related
peptide(s) receptor beta chain]; n=2; Coelomata|Rep:
Putative molluscan insulin-related peptide(s) receptor
precursor (EC 2.7.10.1) [Contains: Putative molluscan
insulin-related peptide(s) receptor alpha chain; Putative
molluscan insulin-related peptide(s) receptor beta chain]
- Lymnaea stagnalis (Great pond snail)
Length = 1607
Score = 222 bits (542), Expect = 3e-56
Identities = 116/289 (40%), Positives = 171/289 (59%), Gaps = 15/289 (5%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLI--PDEEFTLVAVKMLKDEASHDLQLDF 397
++ E R+ I I++LGQG+FG V++ A G+ P+EE VAVK + D AS + +F
Sbjct: 1028 DEWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIP-VAVKTVNDRASFSDRREF 1086
Query: 398 EREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR- 456
+EA + +F ++VKLLGV + G+P ++ E M GDL YLR HR
Sbjct: 1087 LKEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYLRG-----------HRP 1135
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
+ +A +IA GM YL+D+KFVHRDLA RNC+++++ VKI DFG++
Sbjct: 1136 DEDHPGVMPPHLLDILQMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTVKIGDFGMT 1195
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
IY DYY+ +PVRWM ES+ +T SDVW+YGV +WE+ + A QPY G++
Sbjct: 1196 RDIYETDYYRKGGKGMLPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLS 1255
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+EEVV+F+ D ++ P+N P + LM+ CW P+ RP F+ I + L
Sbjct: 1256 NEEVVKFISDGYIMELPENCPNEMAYLMQHCWAKKPNQRPTFKAIIEYL 1304
>UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor;
n=1; Bombyx mori|Rep: Insulin receptor-like protein
precursor - Bombyx mori (Silk moth)
Length = 1472
Score = 221 bits (541), Expect = 3e-56
Identities = 107/279 (38%), Positives = 167/279 (59%), Gaps = 6/279 (2%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E R++I +IR+LGQG+FG V++ A ++ + T A+K + + A+ +++F
Sbjct: 1073 DEWEVTRDSIHFIRELGQGSFGMVYEGIAKEIVKGKPETRCAIKTVNEHATDRERIEFLN 1132
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ FD ++V+LLGV + G+P ++ E M +GDL YLR S P
Sbjct: 1133 EASVMKAFDTFHVVRLLGVVSRGQPTLVVMELMERGDLKTYLR------SMRPDAEGSLP 1186
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+A +IA GM YLS +KFVHRDLA RNC++ D+ VK+ DFG++ I
Sbjct: 1187 SSPPVPPTLQNILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAGDLTVKVGDFGMTRDI 1246
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ +PVRWM ES+ ++ SD W+YGV LWE+ + A+QPY G+++E+
Sbjct: 1247 YETDYYRKGTKGLMPVRWMSPESLKDGVFSSSSDAWSYGVVLWEMATLAMQPYQGLSNEQ 1306
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
V+R++ + V+ P+ P +Y+LM+ CW H PS RP F
Sbjct: 1307 VLRYVVEGGVMERPEQCPDRLYELMRACWTHRPSARPTF 1345
>UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1;
Crassostrea gigas|Rep: Tyrosine-protein kinase receptor
- Crassostrea gigas (Pacific oyster) (Crassostrea
angulata)
Length = 804
Score = 221 bits (541), Expect = 3e-56
Identities = 114/291 (39%), Positives = 175/291 (60%), Gaps = 9/291 (3%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E R+ I IR+LGQG+FG V++ A L VAVK + + A++ +++F
Sbjct: 326 DEWEVERDKIQLIRELGQGSFGMVYEGVARDLYGKGGEIKVAVKTVNEHATYRERMEFLS 385
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTV-----TSFAPVE 454
EA + F ++V+LLGV + G+P L+ E M KGDL +LR V ++FA ++
Sbjct: 386 EASRMKAFSCNHVVRLLGVVSDGQPALLIMELMEKGDLKNFLRMHRPVEEDIDSTFAGIK 445
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
+A +IA GM YL+D+KFVHRDLA RNC++ +D+ VKIADFG
Sbjct: 446 EH----ISRTPPTIKRIIQMAGEIADGMAYLADKKFVHRDLAARNCMVAEDLTVKIADFG 501
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
++ IY DYY+ +PVRWM ES+ +T SDVW+YGV LWE+ + A QPY G
Sbjct: 502 MTRDIYETDYYRKGGKALLPVRWMAPESLKDGIFTSLSDVWSYGVVLWEMATLAAQPYQG 561
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+++EEV+R++ + V+ P++ P +++LM++CW + P RP F+ I + L
Sbjct: 562 LSNEEVLRYVLNGRVMEKPEDCPDRLFELMQKCWRYRPKQRPTFKEILEEL 612
>UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (Xe-InsR) (XTK-1b) [Contains: Insulin receptor
subunit alpha; Insulin receptor subunit beta]; n=6;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (Xe-InsR) (XTK-1b) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Xenopus laevis (African clawed frog)
Length = 1362
Score = 221 bits (541), Expect = 3e-56
Identities = 114/286 (39%), Positives = 166/286 (58%), Gaps = 9/286 (3%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E PR+ I +R+LGQG+FG V++ A +I E VAVK + + AS +++F
Sbjct: 1003 DEWEVPRDKINLLRELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLN 1062
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ F+ ++V+LLGV + G+P ++ E M GDL YLR+ P
Sbjct: 1063 EASVMKAFNCHHVVRLLGVVSKGQPTLVIMELMAHGDLKSYLRSLRPDAENNP------- 1115
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+A +I+ GM YL+ +KFVHRDLA RNC++ DD VKI DFG++ I
Sbjct: 1116 --GRLAPTLKEIIQMAAEISDGMAYLNAKKFVHRDLAARNCMVADDYAVKIGDFGMTRDI 1173
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ +PVRWM ES+ +T SDVW++GV LWEI S A QPY G+++E+
Sbjct: 1174 YETDYYRKGGKGLLPVRWMSPESLKDGVFTAFSDVWSFGVVLWEITSLAEQPYQGLSNEQ 1233
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
V++F+ D L P+N P ++ LM+ CW +NP RP F I L
Sbjct: 1234 VLKFVMDGGSLDHPENCPPRLHSLMQMCWQYNPKMRPTFLEIIDML 1279
>UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror
CG4926-PA; n=3; Endopterygota|Rep: PREDICTED: similar to
Ror CG4926-PA - Apis mellifera
Length = 529
Score = 221 bits (540), Expect = 5e-56
Identities = 132/357 (36%), Positives = 203/357 (56%), Gaps = 24/357 (6%)
Query: 284 LAIAGIALLCHYIVKNHYSKCNVSSRRN-LQNMDIDLDKLPSNLAYHTTGAQL----NPK 338
+A+ I L Y VK NV S+RN L ++L K +T Q +P+
Sbjct: 139 VAVLAILLSIVYCVKKR--SYNVKSQRNSLDGTPMNLKKGLLLANKYTPNPQYFSCASPE 196
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
+ L+ R ++ +++++G+G FG+V++ + I D + +VA+K+LK+ A + + DF
Sbjct: 197 VSILQ--RESLAFLQEIGEGCFGKVYKGEL--CIGDSK-EIVAIKVLKETAPREAEEDFM 251
Query: 399 REACLLADFDHPNIVKLLG-VCAIGRPM-CLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
RE +++ F H NI+ L G V G ++FEYM GDL E LR+ S + +P
Sbjct: 252 REVDIMSTFGHRNILSLKGAVLREGNSSPWMVFEYMPYGDLAEVLRSNSRQFNRSPKPEM 311
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
+ I QIA+GM YLS ++FVHRDLA RNCL+ D +VKIADFG+S
Sbjct: 312 QPLTEESLHW-------ITIQIAAGMTYLSGQRFVHRDLACRNCLVGYDFIVKIADFGMS 364
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
+Y DYYK +P+RWM ES++Y ++TLESDVW++GV LWE++SF QPY+G
Sbjct: 365 RDVYTCDYYKIKGSRLLPIRWMSPESVMYGRFTLESDVWSFGVVLWEVYSFGKQPYYGHN 424
Query: 577 HEE---VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQL 630
+EE VV+ + +L P+ P V +M++CW +P DR F I + L+ +++
Sbjct: 425 NEEVSKVVKLIFQGIMLIPPEGCPPFVCQIMRECWKTDPKDRIKFPEILERLEKVKV 481
>UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin
receptor precursor (IR); n=1; Tribolium castaneum|Rep:
PREDICTED: similar to Insulin receptor precursor (IR) -
Tribolium castaneum
Length = 1293
Score = 221 bits (540), Expect = 5e-56
Identities = 125/346 (36%), Positives = 189/346 (54%), Gaps = 21/346 (6%)
Query: 282 CVLAIAGIALLCHYIVKNHYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQLNPKLEK 341
CVL + A + + +K Y K + + +++ IDL PS + L+K
Sbjct: 846 CVLLLGVFAAV--FFMKRRYEKKVKYTEQYMRHFGIDLRLNPSQIT----------DLDK 893
Query: 342 LEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREA 401
E PRN+++ R LG+GAFG V+ +A PD+ + VAVK LK +S + +LDF EA
Sbjct: 894 WEIPRNSVVINRKLGEGAFGTVYGGEAN--FPDKGWVAVAVKTLKVGSSTEEKLDFLSEA 951
Query: 402 CLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
++ FDH NI+KLLGVC P+ + E+M GDL +L A + + +E +
Sbjct: 952 EVMKRFDHKNIIKLLGVCTKEEPIYTIMEFMLYGDLKTFLLARRHLVNDKTIEESDEISS 1011
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL 521
+A +A G+ YL+ K+VHRD+A+RNCLIN +VK+ADFG++ ++
Sbjct: 1012 KKLTM-------MALDVARGLSYLAQLKYVHRDVASRNCLINAQRIVKLADFGMTRPMFE 1064
Query: 522 QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
DYYK +PVRWM ES+ +T SDVW+YGV L+EI +F PY GMT+ EV+
Sbjct: 1065 NDYYKFTRKGMLPVRWMSPESLALGVFTPSSDVWSYGVLLYEIITFGSFPYQGMTNGEVL 1124
Query: 582 RFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
++K+ + + P + L+K CW+ +P R I + L N
Sbjct: 1125 EYVKNGHTVTIPQGVKTQLRGLLKSCWHQDPKMRTRASEIVEFLAN 1170
>UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2]; n=15;
Eumetazoa|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2] -
Drosophila melanogaster (Fruit fly)
Length = 2144
Score = 220 bits (538), Expect = 8e-56
Identities = 119/316 (37%), Positives = 183/316 (57%), Gaps = 12/316 (3%)
Query: 321 KLPSNLAYHTTGAQLNPKLEKLEF-P------RNNIIYIRDLGQGAFGRVFQAKAPGLIP 373
K+PSN + T ++NP +++ P R NII + LGQG+FG V++ P
Sbjct: 1338 KVPSNDLHMNT--EVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPP 1395
Query: 374 DEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMG 433
+ A+K + + A+ + +F EA ++ +FD ++V+LLGVC+ G+P ++ E M
Sbjct: 1396 NGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMK 1455
Query: 434 KGDLNEYLRACSTVT---SFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKF 490
KGDL YLRA + +R +A +IA GM YL+ +KF
Sbjct: 1456 KGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKF 1515
Query: 491 VHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTL 550
VHRDLA RNC++ DD+ VKI DFG++ IY DYY+ +PVRWMP ES+ Y+
Sbjct: 1516 VHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSS 1575
Query: 551 ESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNH 610
SDV+++GV LWE+ + A QPY G+++E+V+R++ D V+ P+N P ++ LM++CW+H
Sbjct: 1576 ASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHH 1635
Query: 611 NPSDRPNFRVIYQTLD 626
S RP+F I L+
Sbjct: 1636 RSSARPSFLDIIAYLE 1651
>UniRef50_A7SP77 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 293
Score = 219 bits (534), Expect = 2e-55
Identities = 102/271 (37%), Positives = 159/271 (58%), Gaps = 3/271 (1%)
Query: 358 GAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEA-SHDLQLDFEREACLLADFDHPNIVKLL 416
G R+F L E+ +V VK+ K+ S +++ FE EA +L +DHPN+ LL
Sbjct: 14 GPLSRLFLGNMAPLSRGEQDVMVMVKVRKESVPSQEIKDAFEEEALVLTTYDHPNVQSLL 73
Query: 417 GVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIAR 476
GVC IGRP+CL+ EY +GDLN++LR C IA+
Sbjct: 74 GVCVIGRPLCLVLEYSDRGDLNQFLRDCGCSHYIIRERPSSAIDPDSNKLSHLDQLCIAK 133
Query: 477 QIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGD--EHDAIP 534
QIA+GM YL+ R ++H+ L T++C+I+ +M+VKIA+ G+S YY + + P
Sbjct: 134 QIAAGMEYLASRGYIHKQLCTKSCIISKNMIVKIANLGVSDAGPNTSYYHLNTIQKSKYP 193
Query: 535 VRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPD 594
VRW+PLE+I + +D+W+YG+ LWE++S+ + PY+GM +EEV+ ++D ++L P
Sbjct: 194 VRWLPLETIHNGIFDDNTDIWSYGIMLWEVYSYGMTPYYGMNNEEVISLVRDGDILPKPK 253
Query: 595 NTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
PR +Y LM+ CW+ P +RP FR ++Q +
Sbjct: 254 ECPREMYSLMQDCWSLVPHERPRFRYLHQKI 284
>UniRef50_Q0P4R9 Cluster: Discoidin domain receptor family, member
2; n=2; Tetrapoda|Rep: Discoidin domain receptor family,
member 2 - Xenopus tropicalis (Western clawed frog)
(Silurana tropicalis)
Length = 879
Score = 218 bits (533), Expect = 3e-55
Identities = 118/300 (39%), Positives = 167/300 (55%), Gaps = 24/300 (8%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGL-----IPDEEFT----LVAVKMLKDEASHDL 393
EFPRN + LG+G FG V +A GL + EF+ +VAVKML+ + +
Sbjct: 579 EFPRNQLRLKEKLGEGQFGEVHLCEAEGLQEFLEMSPNEFSDQPNMVAVKMLRPDVTKTA 638
Query: 394 QLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPV 453
+ DF +E +++ HPNI++LLGVC P+C++ EYM GDLN++L + F
Sbjct: 639 RNDFLKEIKIISRLKHPNIIRLLGVCVRDDPLCMITEYMENGDLNQFLSQREIRSQFTKA 698
Query: 454 EHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADF 513
+ +A QIA+GM YL+ FVHRDLATRNCL+ + +K+ADF
Sbjct: 699 NN-------IPSVSRQNLLYMAAQIAAGMKYLASLNFVHRDLATRNCLVGNSYTIKVADF 751
Query: 514 GLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL-QPY 572
G+S +Y DYY+ +P+RWM ESIL K+T SD WA+GV LWE+FS QPY
Sbjct: 752 GMSRNLYSGDYYRIQGRAVLPIRWMAWESILLGKFTTCSDAWAFGVTLWEMFSLCKEQPY 811
Query: 573 FGMTHEEVV----RFLKDENVLACPDNTPRC---VYDLMKQCWNHNPSDRPNFRVIYQTL 625
+T E+V+ F +D+ TP C V++LM +CW+ + DRP F I+ L
Sbjct: 812 SVLTDEQVIENTGEFFRDQGRQIYLSQTPLCPGPVFELMMRCWSRDIKDRPTFETIHHFL 871
>UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 277
Score = 218 bits (533), Expect = 3e-55
Identities = 112/289 (38%), Positives = 168/289 (58%), Gaps = 20/289 (6%)
Query: 342 LEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKML--KDEASHDLQLDFER 399
+EFPR+++ +R LG G++GR F A+A G+ E T+V VK L KD+ + DF R
Sbjct: 1 MEFPRHDLEALRTLGNGSYGRAFLARASGIKDGERETMVVVKSLIAKDDIVRE---DFTR 57
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
E L + +H N+V LLGVC P ++FE KGDL ++L +C+
Sbjct: 58 ELESLVNMEHSNVVSLLGVCRDSEPFYMIFECFEKGDLKQFLLSCND------------- 104
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ I SGM YL+ KFVH+DLA RNC++ D+ VKI LS+ +
Sbjct: 105 -NGRSTLTSSHKLTMCSNIVSGMSYLAANKFVHKDLAARNCMVTKDLQVKIGFLNLSYDL 163
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y +YY+ + + IP+RWMP E+I ++ +T +SDVW++GV WEI+S PY + EE
Sbjct: 164 YNAEYYRFN-NILIPLRWMPSEAIFHDDFTEKSDVWSFGVLAWEIYSLGQIPYTDRSDEE 222
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
V++ +KD+ L PDN P + ++MK+CW NP+DRPNF +I+ + +
Sbjct: 223 VLKCVKDDLRLPKPDNCPDNMANVMKKCWEPNPNDRPNFDMIFAEMSEV 271
>UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2;
Culicidae|Rep: Tyrosine protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 722
Score = 217 bits (530), Expect = 7e-55
Identities = 129/354 (36%), Positives = 191/354 (53%), Gaps = 19/354 (5%)
Query: 279 GLGCVLAIAGIALLCHYIVKNHYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQLNPK 338
G CV+ IA I+L + Y + S + LQ IDL PS++ +T
Sbjct: 232 GCLCVMTIAIISLASFCYFQVRYDRKMKHSAKYLQKFGIDLLS-PSSIPVNT-------- 282
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
L+K E P++ ++ R LG+GAFG V+ +A I DE +T VAVK LK ++ + ++DF
Sbjct: 283 LDKWEVPKDRVVINRRLGEGAFGTVYGGEAQ--IGDEGWTAVAVKTLKIGSTTEDKVDFL 340
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
EA + FDH NIVKLLGVC P+ + E+M GDL YL A + + E +
Sbjct: 341 SEAEAMKRFDHNNIVKLLGVCLQTEPVYTIMEFMLYGDLKTYLLARRHLVNSKQSEDSDI 400
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
+A ++ + YL+++K+VHRDLA RNC++N VVK+ DFG++
Sbjct: 401 SPKRLTM--------MALDVSRALSYLAEQKYVHRDLACRNCMVNAQRVVKLGDFGMARP 452
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
+ DYY+ + +PVRWM ES+ +T SDVW+YGV L+EI SF PY GMT+
Sbjct: 453 TFENDYYRFNRKGMLPVRWMAPESLALGIFTPASDVWSYGVLLYEIISFGSFPYQGMTNN 512
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLIL 632
+V+ +K+ N L P + LMK CWN + RP+ + + + N +L
Sbjct: 513 QVLEHVKEGNCLTIPTGVKPQLEGLMKACWNQDYKKRPSASEVSEFIANYPRLL 566
>UniRef50_P14616 Cluster: Insulin receptor-related protein precursor
(EC 2.7.10.1) (IRR) (IR- related receptor) [Contains:
Insulin receptor-related protein alpha chain; Insulin
receptor-related protein beta chain]; n=14; Eutheria|Rep:
Insulin receptor-related protein precursor (EC 2.7.10.1)
(IRR) (IR- related receptor) [Contains: Insulin
receptor-related protein alpha chain; Insulin
receptor-related protein beta chain] - Homo sapiens
(Human)
Length = 1297
Score = 215 bits (526), Expect = 2e-54
Identities = 116/290 (40%), Positives = 169/290 (58%), Gaps = 12/290 (4%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E PR I IR+LGQG+FG V++ A GL EE T VA+K + + AS ++F +
Sbjct: 970 DEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLK 1029
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ F ++V+LLGV + G+P ++ E M +GDL +LR+ P
Sbjct: 1030 EASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNP------- 1082
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+A +IA GM YL+ KFVHRDLA RNC+++ D VKI DFG++ +
Sbjct: 1083 --GLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV 1140
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ +PVRWM ES+ +T SDVW++GV LWEI + A QPY G+++E+
Sbjct: 1141 YETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQ 1200
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQ 629
V++F+ D VL + P + +LM +CW NP RP+F I LD+IQ
Sbjct: 1201 VLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHI---LDSIQ 1247
>UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1;
Ciona intestinalis|Rep: Tyrosine-protein kinase receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 465
Score = 215 bits (525), Expect = 3e-54
Identities = 107/286 (37%), Positives = 164/286 (57%), Gaps = 10/286 (3%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E P N+ + ++G G FG+V++ A ++ + T VAVK L S +++F +
Sbjct: 90 DEYEIPEENVELMDEIGHGHFGKVYEGLAKQVVKGQPKTKVAVKTLHGNESISKRMEFLK 149
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ F+ ++V+LLGV ++ + ++ E+M KGDL YLR S P +
Sbjct: 150 EASVMKAFNSHHVVRLLGVVSMSKRPMVIMEFMAKGDLKTYLR------STRP----DAE 199
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ +IA GM YLS+ K+VHRDLA RNCL+++D+ VKI DFGL+ +
Sbjct: 200 IRKGDPPSLQQKLQMCGEIADGMSYLSETKYVHRDLAARNCLVHEDLTVKIGDFGLTRDV 259
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ D +PVRWM ES+ + SDVW++G+ LWEI + A QPY G H++
Sbjct: 260 YETDYYRIDSRGILPVRWMAPESLKDGVFDSRSDVWSFGIVLWEIATLAEQPYQGQQHDQ 319
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
V RF+ D + P P +YD+M CW+++PS RP F I +L
Sbjct: 320 VTRFVIDGGYMEQPKECPSKLYDMMLMCWHYSPSMRPTFLEIVASL 365
>UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5;
Caenorhabditis|Rep: Receptor tyrosine kinase -
Caenorhabditis elegans
Length = 928
Score = 213 bits (520), Expect = 1e-53
Identities = 112/277 (40%), Positives = 154/277 (55%), Gaps = 11/277 (3%)
Query: 355 LGQGAFGRVFQA-KAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIV 413
+G+G FG V GL E VAVK + +A++ + E+E +A FDHPN++
Sbjct: 596 IGEGQFGVVHSGIYTSGLFAPEPMA-VAVKKCRHDATNAERAQLEQEIRAVATFDHPNVI 654
Query: 414 KLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXX 473
KL+GVC + + +FEYM GDL+E L+ P +H
Sbjct: 655 KLIGVCYMDNSLLAVFEYMVHGDLHELLKV-----RVPPADH----DMGGITEANAEFLY 705
Query: 474 IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAI 533
IA QIA GM YL+ FVHRDLATRNCL+ D +KIADFGL Y DYYK +
Sbjct: 706 IATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKMLHRSWM 765
Query: 534 PVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACP 593
PVRWM E+I +++ SDVW++GV LWEI+SF QPY G ++++V+ + + ++L CP
Sbjct: 766 PVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLLECP 825
Query: 594 DNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQL 630
N P +Y LM +CW+ N RP F I L + L
Sbjct: 826 HNCPTNIYSLMVECWHENIERRPTFSEIRSRLQSWSL 862
Score = 86.2 bits (204), Expect = 2e-15
Identities = 58/234 (24%), Positives = 101/234 (43%), Gaps = 17/234 (7%)
Query: 21 CGPYNGQVCKSY-STGYVWYNHTGGLDNEKITSGLWKEMI-----SNLQEPCRTQAERLL 74
C Y G+ C+ Y S +V + + I L M+ + + CR ++ +
Sbjct: 205 CVQYRGEACRQYLSNKFVMMTNESREEMYDIDRNLRAAMLFINGAPTISQKCRQLSQAVA 264
Query: 75 CAYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLP 134
C + + C D + +C DC ++ C ++ + + Q E V + F P
Sbjct: 265 CHHMYKVC-ESDSNNQI-VSICKHDCDVIQNDECPSE-LALAAQHEL-VGDTPKALF--P 318
Query: 135 ECENLPHYSG--KGSQVSCNNIGITDMDLDQVTTTCVKGNGRYYQGVINETKAGLACQAW 192
C L S + + + +++ +T C +G Y+G + +T +G C W
Sbjct: 319 LCSRLSSTSNCIPVMSTALQSSPVAEVNRGHLTHWCYVNSGTQYEGTVAQTSSGKQCAPW 378
Query: 193 ESQFPHQHTRPPLVFPEVQNSSNYCRNAGGEENRPWCYTMHPNVRWQYCEIPMC 246
FPE+ NS NYCRN GG+++RPWCY+ P + +YC++P C
Sbjct: 379 IDSTSRDFNVHR--FPELMNSKNYCRNPGGKKSRPWCYS-KPMGQEEYCDVPQC 429
>UniRef50_Q70W12 Cluster: Discoidin receptor; n=1; Ciona
intestinalis|Rep: Discoidin receptor - Ciona
intestinalis (Transparent sea squirt)
Length = 457
Score = 213 bits (519), Expect = 2e-53
Identities = 113/300 (37%), Positives = 164/300 (54%), Gaps = 25/300 (8%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPD------------EEFTLVAVKMLKDEAS 390
EFPR + + LG+G FG V KA + +E LVAVK+L+ +A+
Sbjct: 133 EFPREKLEVVEQLGEGQFGEVQLCKAHNSLRKLVSAPFQFSGELDEPVLVAVKVLRADAT 192
Query: 391 HDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSF 450
+ + DF +E +++ PNIV L+ VC P ++ EYM GDLN+YLR+C+ +
Sbjct: 193 SNAKEDFLKEVRVMSQMQDPNIVHLIAVCTNDEPYAMITEYMENGDLNQYLRSCADKMNS 252
Query: 451 APVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKI 510
P + QIASGM YLS KFVHRDLATRNCL++ + ++I
Sbjct: 253 DPSSKENSLFSSNEVLIN-----MCVQIASGMRYLSSHKFVHRDLATRNCLVDSNHSIRI 307
Query: 511 ADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFA-L 569
ADFG+S +Y DYY+ +P+RWM E +L K++ SD WA+GV LWEIFSF L
Sbjct: 308 ADFGMSRNMYQSDYYRIQGRAVLPIRWMSWECVLMGKFSSASDAWAFGVTLWEIFSFCKL 367
Query: 570 QPYFGMTHEEVVRFLK-------DENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIY 622
QP+ +T ++V+ + +E L P P +++L++QCW P DRP F ++
Sbjct: 368 QPHNSLTDQQVIENMHHVFKRTGEEVHLQRPKRCPATLFNLIRQCWKRQPEDRPTFEQLH 427
>UniRef50_Q4RPK6 Cluster: Chromosome 12 SCAF15007, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 12
SCAF15007, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 878
Score = 212 bits (518), Expect = 2e-53
Identities = 117/302 (38%), Positives = 170/302 (56%), Gaps = 26/302 (8%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGL---------IPDEE--FTLVAVKMLKDEASH 391
EFPR +I+ LG+G FG V +A GL +P+ + LVAVK L+ +A+
Sbjct: 584 EFPRQQLIFREKLGEGQFGEVHLCEAEGLPEFLGEGSPLPERDGHSVLVAVKQLRADATS 643
Query: 392 DLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFA 451
+ DF +E +++ + PNI++LL VC P+C++ EYM GDLN +L S
Sbjct: 644 QARNDFLKEIKIMSRLNDPNIIRLLCVCVSSDPLCMVTEYMENGDLNMFL-------SQR 696
Query: 452 PVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIA 511
+E +A QI+SGM YL+ FVHRDLATRNCL++ + +KIA
Sbjct: 697 EIESTLTHANNIPSVSLSDLLHMAVQISSGMKYLASLNFVHRDLATRNCLLDRRLTIKIA 756
Query: 512 DFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL-Q 570
DFG+S +Y DYY+ +P+RWM ESIL K+T SDVWA+GV LWEIF+ Q
Sbjct: 757 DFGMSRNLYSSDYYRIQGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQ 816
Query: 571 PYFGMTHEEVV----RFLKDEN---VLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQ 623
PY ++ E+V+ F +++ L P P +++LM +CW+ + DRPNF +Y+
Sbjct: 817 PYSLLSDEQVIENTGEFFRNQGRQIFLYAPPLCPPSLFELMMRCWSRDIHDRPNFEGLYR 876
Query: 624 TL 625
L
Sbjct: 877 AL 878
>UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2;
Strongylocentrotus purpuratus|Rep: Tyrosine-protein
kinase receptor - Strongylocentrotus purpuratus (Purple
sea urchin)
Length = 1072
Score = 212 bits (518), Expect = 2e-53
Identities = 106/293 (36%), Positives = 170/293 (58%), Gaps = 11/293 (3%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEE-FTLVAVKMLKDEASHDLQLDFE 398
++ EFPR+ + IR+LG+G+FG V++ A G++P+EE + VA+K ++ AS +++F
Sbjct: 690 DEWEFPRDKLEIIRELGKGSFGMVYEGLAKGILPEEEEISRVAIKSVQANASMRDRIEFL 749
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
EA ++ D N+V+LLGV + G+P ++ E+M +GDL +LRA E
Sbjct: 750 NEASVMKLIDAHNVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRA----------RRPEN 799
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
+A +IA GM +L+ RK+VHRDL+ RNCL++ + K+ADFGL+
Sbjct: 800 QQDLPSVPTLEQLLNMAAEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLARD 859
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
IY DYY+ + +P+RWM ES+ + SDVW++G+ LWE+ + PY G+++E
Sbjct: 860 IYQSDYYRKERGGMLPIRWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNE 919
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLI 631
E ++K NVL P+N P + ++M CW + RP F I L + L+
Sbjct: 920 EAGEYIKGGNVLRPPENCPEKMQEIMMACWQYQEKLRPLFGEIILNLQDYGLL 972
>UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to RE05926p, partial -
Strongylocentrotus purpuratus
Length = 859
Score = 210 bits (513), Expect = 9e-53
Identities = 107/289 (37%), Positives = 163/289 (56%), Gaps = 4/289 (1%)
Query: 341 KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFERE 400
K+EFPRN + LG G+F V++A+A G+I EE T+VAVK LK+ A+ + + D +E
Sbjct: 305 KMEFPRNRLTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSKE 364
Query: 401 ACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
L D HPNIV +LG C P ++ EY+ +L YLR T S ++R
Sbjct: 365 LSLYMYLDPHPNIVNILGCCTDSDPWYIIMEYLPNNNLQGYLRQIRTGESMT-ADYRNVK 423
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ QIA GM YL+ R+ +HRDLA RN L+ + V K++DFGL+ +
Sbjct: 424 KQKDIPPNDLLTFGV--QIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDL 481
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y+ +PVRWM ES+L+N YT +SDVW++ + +WEI + PY GM+ ++
Sbjct: 482 EDGQTYEMKSQGRVPVRWMSPESLLHNTYTSQSDVWSFAILIWEIVTLGSHPYPGMSSKQ 541
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
VV+ + L P++ + +Y+LMK+CW + +RP F + L+N+
Sbjct: 542 VVKEISAGYRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQVKVRLENM 590
Score = 75.8 bits (178), Expect = 3e-12
Identities = 37/80 (46%), Positives = 52/80 (65%), Gaps = 1/80 (1%)
Query: 341 KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFERE 400
K+EFPRN + + LG G+F V++A+A G+I E+ T+VAVK LKD A+ + + D +E
Sbjct: 130 KMEFPRNRLTLLNKLGSGSFADVYKAEALGIITKEQKTIVAVKRLKDTATENDKSDLSKE 189
Query: 401 ACLLADFD-HPNIVKLLGVC 419
L D HPNIV +LG C
Sbjct: 190 LSLYMYLDPHPNIVNILGCC 209
>UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4
variant; n=28; Eumetazoa|Rep: Fibroblast growth factor
receptor 4 variant - Homo sapiens (Human)
Length = 1034
Score = 210 bits (513), Expect = 9e-53
Identities = 116/292 (39%), Positives = 168/292 (57%), Gaps = 8/292 (2%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIP--DEEFTLVAVKMLKDEASH-DL-QLDFE 398
EFPR+ ++ + LG+G FG+V +A+A G+ P ++ + VAVKMLKD AS DL L E
Sbjct: 693 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 752
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
E L H NI+ LLGVC P+ ++ E KG+L E+LRA P +
Sbjct: 753 MEVMKLIG-RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPP---GPDLSPDG 808
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
A Q+A GM YL RK +HRDLA RN L+ +D V+KIADFGL+
Sbjct: 809 PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARG 868
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
++ DYYK + +PV+WM E++ YT +SDVW++G+ LWEIF+ PY G+ E
Sbjct: 869 VHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVE 928
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQL 630
E+ L++ + + P + P +Y LM++CW+ PS RP F+ + + LD + L
Sbjct: 929 ELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 980
>UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4
precursor; n=9; Eutheria|Rep: Fibroblast growth factor
receptor 4 precursor - Mus musculus (Mouse)
Length = 799
Score = 210 bits (513), Expect = 9e-53
Identities = 116/292 (39%), Positives = 167/292 (57%), Gaps = 8/292 (2%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPD--EEFTLVAVKMLKDEASH-DL-QLDFE 398
EFPR+ ++ + LG+G FG+V +A+A G+ P ++ + VAVKMLKD AS DL L E
Sbjct: 458 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSE 517
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
E L H NI+ LLGVC P+ ++ E KG+L E+LRA P +
Sbjct: 518 MEVMKLIG-RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPP---GPDLSPDG 573
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
A Q+A GM YL RK +HRDLA RN L+ +D V+KIADFGL+
Sbjct: 574 PRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARG 633
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
++ DYYK + +PV+WM E++ YT +SDVW++ + LWEIF+ PY G+ E
Sbjct: 634 VHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVE 693
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQL 630
E+ L++ + + P N P +Y LM++CW+ PS RP F+ + + LD + L
Sbjct: 694 ELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 745
>UniRef50_UPI0000E48069 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 913
Score = 210 bits (512), Expect = 1e-52
Identities = 115/303 (37%), Positives = 164/303 (54%), Gaps = 20/303 (6%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGL-------IPDE-----EFTLVAVKMLKDEAS 390
E+PR+ + ++ LG+G FG V +A + P E E TLVAVKML+ +AS
Sbjct: 598 EYPRSQLNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERTLVAVKMLRKDAS 657
Query: 391 HDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSF 450
+ + DF +E +++ PNIV+LL C P C++ EYM GDLN++L
Sbjct: 658 KNARADFMKEMKIMSQLRDPNIVRLLAACTEDEPYCMIVEYMENGDLNQFLYEREGFEVG 717
Query: 451 APVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKI 510
+ + QIASGM YLS+ FVHRDLATRNCL+ ++I
Sbjct: 718 LNNCNANLSNCNKSSISVGALVYMITQIASGMKYLSNMNFVHRDLATRNCLVGKSYTIRI 777
Query: 511 ADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL- 569
ADFG+S +Y +YY+ + +P+RWM ESIL K+T ++DVWA+GV LWE+
Sbjct: 778 ADFGMSRNLYSSNYYRIEGRAVLPIRWMAWESILLGKFTSKTDVWAFGVTLWEVMMLCRE 837
Query: 570 QPYFGMTHEEVVR-----FLKDEN--VLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIY 622
QPY +T E+V+ F KD LA P P+ +++LMK+CW P RP F ++
Sbjct: 838 QPYSRLTDEQVIENTGQFFEKDGTPVYLAKPPQCPKDIHNLMKRCWTSEPGQRPTFDFLH 897
Query: 623 QTL 625
L
Sbjct: 898 TFL 900
>UniRef50_Q5RIU8 Cluster: Novel protein similar to vertebrate
discoidin domain receptor family, member 2; n=4; Danio
rerio|Rep: Novel protein similar to vertebrate discoidin
domain receptor family, member 2 - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 804
Score = 210 bits (512), Expect = 1e-52
Identities = 113/302 (37%), Positives = 174/302 (57%), Gaps = 26/302 (8%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGL---------IPDEEF--TLVAVKMLKDEASH 391
EFPR +++ LG+G FG V +A GL +P+++ LVAVK L+ +A+
Sbjct: 503 EFPRQRLLFREKLGEGQFGEVHLCEAEGLAEFLGEGAPLPEQDGRPVLVAVKQLRADATS 562
Query: 392 DLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFA 451
+ + DF +E +++ ++PNI++LL VC P+C++ EYM GDLN +L S
Sbjct: 563 NARNDFLKEIKIMSRLNNPNIIQLLCVCVSSDPLCMVTEYMENGDLNMFL-------SQR 615
Query: 452 PVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIA 511
+E ++ QI+SGM YL+ FVHRDLATRNCL++ + +KI+
Sbjct: 616 EIESTLTHANNIPSVSIADLLHMSVQISSGMKYLASLNFVHRDLATRNCLLDRHLTIKIS 675
Query: 512 DFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL-Q 570
DFG+S +Y DYY+ +P+RWM ESIL K+T SDVWA+GV LWEIF+ Q
Sbjct: 676 DFGMSRNLYSSDYYRIQGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQ 735
Query: 571 PYFGMTHEEVV----RFLKDEN---VLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQ 623
PY ++ E+V+ F +++ L+ P P ++ LM +CW+ + +DRP+F ++Q
Sbjct: 736 PYSLLSDEQVIENTGEFFRNQGRQIFLSAPPLCPSSLFKLMMRCWSRDITDRPSFNKLHQ 795
Query: 624 TL 625
L
Sbjct: 796 AL 797
>UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; Homo
sapiens|Rep: Tyrosine-protein kinase receptor - Homo
sapiens (Human)
Length = 1310
Score = 210 bits (512), Expect = 1e-52
Identities = 110/287 (38%), Positives = 153/287 (53%), Gaps = 15/287 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E PR NI IR LG GAFG V++ + G+ D VAVK L + S +LDF EA
Sbjct: 800 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 859
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
+++ F+H NIV+ +GV P +L E M GDL +LR T P +
Sbjct: 860 IISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRE----TRPRPSQP------- 908
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN---DDMVVKIADFGLSHKI 519
+AR IA G YL + F+HRD+A RNCL+ V KI DFG++ I
Sbjct: 909 -SSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI 967
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y YY+ +PV+WMP E+ + +T ++D W++GV LWEIFS PY +++E
Sbjct: 968 YRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQE 1027
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
V+ F+ + P N P VY +M QCW H P DRPNF +I + ++
Sbjct: 1028 VLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE 1074
>UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;
n=37; Euteleostomi|Rep: ALK tyrosine kinase receptor
precursor - Homo sapiens (Human)
Length = 1620
Score = 210 bits (512), Expect = 1e-52
Identities = 110/287 (38%), Positives = 153/287 (53%), Gaps = 15/287 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E PR NI IR LG GAFG V++ + G+ D VAVK L + S +LDF EA
Sbjct: 1110 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 1169
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
+++ F+H NIV+ +GV P +L E M GDL +LR T P +
Sbjct: 1170 IISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRE----TRPRPSQP------- 1218
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN---DDMVVKIADFGLSHKI 519
+AR IA G YL + F+HRD+A RNCL+ V KI DFG++ I
Sbjct: 1219 -SSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI 1277
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y YY+ +PV+WMP E+ + +T ++D W++GV LWEIFS PY +++E
Sbjct: 1278 YRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQE 1337
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
V+ F+ + P N P VY +M QCW H P DRPNF +I + ++
Sbjct: 1338 VLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE 1384
>UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2;
Cellia|Rep: Tyrosine-protein kinase receptor - Anopheles
gambiae str. PEST
Length = 1318
Score = 209 bits (511), Expect = 2e-52
Identities = 108/288 (37%), Positives = 168/288 (58%), Gaps = 8/288 (2%)
Query: 338 KLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDF 397
K+++ E PR +II + +LGQG+FG V++ L D A+K + + A+ + F
Sbjct: 982 KVDEWEVPREHIIQLEELGQGSFGMVYKGIMTKLGNDVNVPC-AIKTVTENATERERDSF 1040
Query: 398 EREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHRE 457
EA ++ +F ++V+L GV ++G+P ++ E M GDL YLR P ++
Sbjct: 1041 LIEATIMKEFHTHHVVRLYGVVSVGQPTLVIMELMANGDLKSYLRR------HRP-DYEN 1093
Query: 458 XXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSH 517
+A +IA GM YL+ +KFVHRDLA RNC++ +D+ VKI DFG++
Sbjct: 1094 GEESSPQPPTLKQIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVAEDLTVKIGDFGMTR 1153
Query: 518 KIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTH 577
IY DYY+ +PVRWM ES+ ++ SDV++YGV LWE+ + A QPY G+T+
Sbjct: 1154 DIYETDYYRKGTKGFLPVRWMAPESLKDGMFSSSSDVFSYGVVLWEMATLASQPYQGLTN 1213
Query: 578 EEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
++V+R++ D V+ P+N P +Y+LM+ CW H S RP+F I + L
Sbjct: 1214 DQVLRYVIDGGVMERPENCPDKLYELMRICWQHRASARPSFIDIIRML 1261
>UniRef50_Q16832 Cluster: Discoidin domain-containing receptor 2
precursor; n=54; Euteleostomi|Rep: Discoidin
domain-containing receptor 2 precursor - Homo sapiens
(Human)
Length = 855
Score = 209 bits (510), Expect = 2e-52
Identities = 118/302 (39%), Positives = 164/302 (54%), Gaps = 28/302 (9%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGL--IPDEEFTL---------VAVKMLKDEASH 391
EFPR + + LG+G FG V + G+ D++F L VAVKML+ +A+
Sbjct: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 616
Query: 392 DLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFA 451
+ + DF +E +++ PNI+ LL VC P+C++ EYM GDLN++L +
Sbjct: 617 NARNDFLKEIKIMSRLKDPNIIHLLSVCITDDPLCMITEYMENGDLNQFL---------S 667
Query: 452 PVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIA 511
E +A QIASGM YLS FVHRDLATRNCL+ + +KIA
Sbjct: 668 RHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIA 727
Query: 512 DFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL-Q 570
DFG+S +Y DYY+ +P+RWM ESIL K+T SDVWA+GV LWE F+F Q
Sbjct: 728 DFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQ 787
Query: 571 PYFGMTHEEVV----RFLKD---ENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQ 623
PY ++ E+V+ F +D + L P P VY LM CW + +RP+F+ I+
Sbjct: 788 PYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHL 847
Query: 624 TL 625
L
Sbjct: 848 LL 849
>UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin
receptor; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to insulin receptor - Nasonia vitripennis
Length = 1714
Score = 208 bits (508), Expect = 3e-52
Identities = 104/284 (36%), Positives = 167/284 (58%), Gaps = 19/284 (6%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E PR + +++LG G+FG V++ A ++ + AVK + + A+ +++F
Sbjct: 1120 DEWEVPRKKVHLLKELGNGSFGMVYEGIAKDVVKGKPEMRCAVKTVNENATDRERVEFLN 1179
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRA-----CSTVTSFAPVE 454
EA ++ F+ ++V+LLGV + G+P ++ E M GDL YLR+ C + P
Sbjct: 1180 EASVMKGFNTHHVVRLLGVVSQGQPTLVVMELMVNGDLKTYLRSHRPDVCENFSRQPPTL 1239
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
+R +A +IA GM YL+ +KFVHRDLA RNC+++DD+ VKI DFG
Sbjct: 1240 NR--------------IMRMALEIADGMAYLAAKKFVHRDLAARNCMVSDDLTVKIGDFG 1285
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
++ +Y DYY+ +PVRWM ES+ +T SDVW+YGV LWE+ + A QPY G
Sbjct: 1286 MTRDVYETDYYRKGTKGLLPVRWMAPESLKDGVFTSFSDVWSYGVVLWEMVTLASQPYQG 1345
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
+++++V+R++ D V+ P+N P +Y +M+Q W H + RP F
Sbjct: 1346 LSNDQVLRYVIDGGVMERPENCPDILYGMMRQTWCHKATRRPTF 1389
>UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|Rep:
Protein tyrosine kinase - Ephydatia fluviatilis
Length = 2069
Score = 208 bits (508), Expect = 3e-52
Identities = 117/294 (39%), Positives = 165/294 (56%), Gaps = 18/294 (6%)
Query: 339 LEKLE-FPRNNIIYIRDLGQGAFGRVFQAKAPGLI-PDEEFTLVAVKMLKDEASHDLQLD 396
LE L+ FPR N+ + +G FG VFQ A ++ P VAVK L+ A + Q
Sbjct: 1691 LELLQKFPRGNLKLENFIDRGEFGEVFQGTATDILGPGTGPIPVAVKTLRKGAIIEEQKK 1750
Query: 397 FEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
F EA L+ +F+HPNIVK+LGVC P+ ++ E M GDL +LR + +
Sbjct: 1751 FLAEAALMGNFNHPNIVKVLGVCVENDPVYIIMELMPGGDLLHFLRDAKVERGPPLLTVK 1810
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIND---DMVVKIADF 513
E IA +A G YL F+HRDLA RNCL++ D VVKI DF
Sbjct: 1811 ELIQ-------------IALDVAQGCHYLQQTHFIHRDLAARNCLVSSKGADRVVKIGDF 1857
Query: 514 GLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYF 573
GL+ +Y DYY+ + +PVRWM E++L K+ +ESDVW++GV +WEI +F QPY
Sbjct: 1858 GLAKDLYSSDYYQVEGQRKLPVRWMAPEALLQGKFNMESDVWSFGVLMWEIMTFGNQPYP 1917
Query: 574 GMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
+ ++EV++F+ E L P+N P +Y LM+ CW S+R +F VI + L+N
Sbjct: 1918 ALNNQEVLQFVTAEGRLQKPENCPGKIYQLMQNCWKKVASERLHFDVIKEILNN 1971
>UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 1084
Score = 208 bits (507), Expect = 5e-52
Identities = 119/301 (39%), Positives = 159/301 (52%), Gaps = 18/301 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTL-VAVKMLKDEASHDLQLDFEREA 401
E R NI R LG GAFG V++ A G IP E L VAVK L + S +LDF EA
Sbjct: 493 EVSRRNISLTRGLGHGAFGEVYEGLAVG-IPGEPSPLQVAVKTLPEVCSEQDELDFLMEA 551
Query: 402 CLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
+++ F H NIV+ +GV P +L E M GDL ++R T P EH
Sbjct: 552 LIISKFSHQNIVRCVGVSLQAMPRFILLELMTGGDLKTFMRE----TRPRP-EHPSSLTM 606
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN---DDMVVKIADFGLSHK 518
IAR IA G YL + +F+HRD+A RNCL+ V KI DFG++
Sbjct: 607 VDLLN-------IARDIAKGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARD 659
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
IY YY+ +PV+WMP E+ + +T ++D W++GV LWEIFS PY +++
Sbjct: 660 IYRASYYRKGGRAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQ 719
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN-IQLILERGRT 637
EV+ F+ + + P N P VY +M QCW H P DRPNF I + +D +Q RG
Sbjct: 720 EVLEFVTNGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFSTILERIDYCLQPARHRGGP 779
Query: 638 H 638
H
Sbjct: 780 H 780
>UniRef50_Q08345 Cluster: Epithelial discoidin domain-containing
receptor 1 precursor; n=40; Mammalia|Rep: Epithelial
discoidin domain-containing receptor 1 precursor - Homo
sapiens (Human)
Length = 913
Score = 208 bits (507), Expect = 5e-52
Identities = 110/304 (36%), Positives = 169/304 (55%), Gaps = 19/304 (6%)
Query: 341 KLEFPRNNIIYIRDLGQGAFGRVF--QAKAPGLIPDEEFTL---------VAVKMLKDEA 389
+++FPR+ + + LG+G FG V + +P + +F L VAVK+L+ +A
Sbjct: 602 RVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA 661
Query: 390 SHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTS 449
+ + + DF +E +++ PNI++LLGVC P+C++ +YM GDLN++L A
Sbjct: 662 TKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDK 721
Query: 450 FAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVK 509
A + +A QIASGM YL+ FVHRDLATRNCL+ ++ +K
Sbjct: 722 AAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 781
Query: 510 IADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFA- 568
IADFG+S +Y DYY+ +P+RWM E IL K+T SDVWA+GV LWE+
Sbjct: 782 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 841
Query: 569 LQPYFGMTHEEVV----RFLKDEN---VLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVI 621
QP+ +T E+V+ F +D+ L+ P P+ +Y+LM +CW+ RP F +
Sbjct: 842 AQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 901
Query: 622 YQTL 625
++ L
Sbjct: 902 HRFL 905
>UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain]; n=2; Aedes
aegypti|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain] - Aedes aegypti
(Yellowfever mosquito)
Length = 1390
Score = 206 bits (502), Expect = 2e-51
Identities = 110/288 (38%), Positives = 165/288 (57%), Gaps = 8/288 (2%)
Query: 338 KLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDF 397
K++ E RN+II + +LGQG+FG V++ L ++ A+K + + A+ + F
Sbjct: 1014 KVDDWEVERNHIIQLEELGQGSFGMVYKGILTQLRGEKCNQPCAIKTVNESATAREKDSF 1073
Query: 398 EREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHRE 457
EA ++ F+ ++V+LLGV + G P ++ E M GDL YLR P E
Sbjct: 1074 LLEASVMKQFNTHHVVRLLGVVSQGDPTLVIMELMANGDLKSYLRR------HRP--DYE 1125
Query: 458 XXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSH 517
+A +IA G+ LS +KFVHRDLA RNC++ DDM VKI DFG++
Sbjct: 1126 MRRSIRQPPTLRQIIQMAIEIADGIGVLSAKKFVHRDLAARNCMVADDMTVKIGDFGMTR 1185
Query: 518 KIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTH 577
IY DYY+ +PVRWM ES+ ++ SDV++YGV LWE+ + A QPY G+T+
Sbjct: 1186 DIYETDYYRKGTKGFLPVRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLASQPYQGLTN 1245
Query: 578 EEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
++V+R++ D V+ P+N P +Y+LM++CW H P+ RP F I L
Sbjct: 1246 DQVLRYVIDGGVMERPENCPDNLYNLMRRCWQHRPTARPTFMEIISEL 1293
>UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic
lymphoma kinase (Ki-1),; n=1; Danio rerio|Rep: PREDICTED:
similar to anaplastic lymphoma kinase (Ki-1), - Danio
rerio
Length = 1387
Score = 205 bits (501), Expect = 2e-51
Identities = 110/287 (38%), Positives = 151/287 (52%), Gaps = 15/287 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E PR NI R LG GAFG V++ A G+ + VAVK L + S +LDF EA
Sbjct: 789 EVPRRNISLTRGLGHGAFGEVYEGLAVGIPGEPSPMQVAVKTLPEVCSEQDELDFLMEAL 848
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
+++ F H NIV+ +GV P +L E M GDL +LR +EH
Sbjct: 849 IISKFSHQNIVRCIGVSLQALPHFILLELMAGGDLKSFLRETRP-----RLEHPSSLTMV 903
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN---DDMVVKIADFGLSHKI 519
IAR IA G YL + +F+HRD+A RNCL+ V KI DFG++ I
Sbjct: 904 DLLN-------IARDIARGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDI 956
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y YY+ +PV+WMP E+ + +T ++D W++GV LWEIFS PY +++E
Sbjct: 957 YRASYYRKGGRAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQE 1016
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
V+ F+ + + P N P VY +M Q W H P DRPNF I + +D
Sbjct: 1017 VLEFVTNGGRMDPPKNCPGPVYRIMTQSWQHQPEDRPNFSTILERID 1063
>UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5;
Euteleostomi|Rep: Tyrosine-protein kinase receptor -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 1161
Score = 205 bits (501), Expect = 2e-51
Identities = 122/355 (34%), Positives = 177/355 (49%), Gaps = 29/355 (8%)
Query: 286 IAGIALLCHYIVKNHYSKCNV--SSRRNLQNMDIDLDKLPS---------NLAYHTTGAQ 334
+ G+ L C + +Y K N + R LQ+ + L K+ S N Y A
Sbjct: 495 VTGVVLTCASLTLIYYRKKNHLHAVRIRLQSPEYKLSKIRSSTIMTDYNPNYGYFGKAAS 554
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ 394
L+ E E PR NI +R LG GAFG V++ + G+ + VA+K L + S +
Sbjct: 555 LS---ELKEVPRKNITLLRALGHGAFGEVYEGQVLGMNGENTAMQVAIKTLPEICSEQDE 611
Query: 395 LDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
+DF EA +++ F H NIV+ +GV P +L E M GD+ +LR T+ +
Sbjct: 612 MDFLMEALIMSKFSHQNIVRCIGVSLQILPRFILLELMTGGDMKSFLRLNRPRTNHS--- 668
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN---DDMVVKIA 511
+AR IA G YL + F+HRD+A RNCL+ D V KI
Sbjct: 669 ---------SSLSMLELLHMARDIALGCRYLEENHFIHRDIAARNCLLTCPGPDRVAKIG 719
Query: 512 DFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQP 571
DFG++ IY YY+ +PV+WMP E+ L +T ++D W++GV LWEIFS P
Sbjct: 720 DFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGYMP 779
Query: 572 YFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
Y T++EV+ F+ + P + P VY +M QCW H P RPNF I + ++
Sbjct: 780 YPCKTNQEVLEFVTGGGRMDPPKSCPGPVYRIMTQCWQHCPEHRPNFTTILERIN 834
>UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming
protein ros; n=3; root|Rep: Tyrosine-protein kinase
transforming protein ros - Avian sarcoma virus (strain
UR2)
Length = 402
Score = 205 bits (501), Expect = 2e-51
Identities = 116/314 (36%), Positives = 167/314 (53%), Gaps = 20/314 (6%)
Query: 324 SNLAYHTTGAQLNPKLEKLE-FPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEF-TLVA 381
+N Y + ++E L FPR+ + + LG GAFG V++ A ++ D + VA
Sbjct: 72 ANACYAVSTLPSQAEIESLPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVA 131
Query: 382 VKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYL 441
VK LK A+ + +F +EA L++ FDHP+I+KLLGVC + P L+ E M GDL YL
Sbjct: 132 VKTLKRGATDQEKSEFLKEAHLMSKFDHPHILKLLGVCLLNEPQYLILELMEGGDLLSYL 191
Query: 442 RACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCL 501
R +P+ I I G +YL +F+HRDLA RNCL
Sbjct: 192 RGARKQKFQSPL------------LTLTDLLDICLDICKGCVYLEKMRFIHRDLAARNCL 239
Query: 502 INDDM------VVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVW 555
+++ VVKI DFGL+ IY DYY+ +PVRWM ES++ +T SDVW
Sbjct: 240 VSEKQYGSCSRVVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLIDGVFTNHSDVW 299
Query: 556 AYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDR 615
A+GV +WE + QPY G+++ EV+ ++ L P+N P + DLM +CW +P +R
Sbjct: 300 AFGVLVWETLTLGQQPYPGLSNIEVLHHVRSGGRLESPNNCPDDIRDLMTRCWAQDPHNR 359
Query: 616 PNFRVIYQTLDNIQ 629
P F I L I+
Sbjct: 360 PTFFYIQHKLQEIR 373
>UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta
cDNA, RIKEN full-length enriched library,
clone:I530025O09 product:fibroblast growth factor
receptor 1, full insert sequence; n=18; Eumetazoa|Rep:
14 days pregnant adult female placenta cDNA, RIKEN
full-length enriched library, clone:I530025O09
product:fibroblast growth factor receptor 1, full insert
sequence - Mus musculus (Mouse)
Length = 386
Score = 205 bits (500), Expect = 3e-51
Identities = 114/298 (38%), Positives = 167/298 (56%), Gaps = 12/298 (4%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDE--EFTLVAVKMLKDEASHDLQ 394
P+ + E PR+ ++ + LG+G FG+V A+A GL D+ T VAVKMLK +A+
Sbjct: 30 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 89
Query: 395 LDFEREACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRAC---STVTSF 450
D E ++ H NI+ LLG C P+ ++ EY KG+L EYL+A +
Sbjct: 90 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 149
Query: 451 APVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKI 510
P + E A Q+A GM YL+ +K +HRDLA RN L+ +D V+KI
Sbjct: 150 NPSHNPEEQLSSKDLVS------CAYQVARGMEYLASKKCIHRDLAARNALVTEDNVMKI 203
Query: 511 ADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQ 570
ADFGL+ I+ DYYK + +PV+WM E++ YT +SDVW++GV LWEIF+
Sbjct: 204 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 263
Query: 571 PYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
PY G+ EE+ + LK+ + + P N +Y +M+ CW+ PS RP F+ + + LD I
Sbjct: 264 PYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 321
>UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor 1
precursor; n=310; Euteleostomi|Rep: Basic fibroblast
growth factor receptor 1 precursor - Homo sapiens
(Human)
Length = 822
Score = 204 bits (499), Expect = 4e-51
Identities = 114/298 (38%), Positives = 167/298 (56%), Gaps = 12/298 (4%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDE--EFTLVAVKMLKDEASHDLQ 394
P+ + E PR+ ++ + LG+G FG+V A+A GL D+ T VAVKMLK +A+
Sbjct: 466 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 525
Query: 395 LDFEREACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRAC---STVTSF 450
D E ++ H NI+ LLG C P+ ++ EY KG+L EYL+A +
Sbjct: 526 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 585
Query: 451 APVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKI 510
P + E A Q+A GM YL+ +K +HRDLA RN L+ +D V+KI
Sbjct: 586 NPSHNPEEQLSSKDLVS------CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 639
Query: 511 ADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQ 570
ADFGL+ I+ DYYK + +PV+WM E++ YT +SDVW++GV LWEIF+
Sbjct: 640 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 699
Query: 571 PYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
PY G+ EE+ + LK+ + + P N +Y +M+ CW+ PS RP F+ + + LD I
Sbjct: 700 PYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 757
>UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Rep:
Isoform of FGFR2 - Homo sapiens (Human)
Length = 709
Score = 204 bits (498), Expect = 6e-51
Identities = 113/296 (38%), Positives = 166/296 (56%), Gaps = 8/296 (2%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDE--EFTLVAVKMLKDEASHDLQ 394
P+ K EFPR+ + + LG+G FG+V A+A G+ D+ E VAVKMLKD+A+
Sbjct: 357 PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL 416
Query: 395 LDFEREACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPV 453
D E ++ H NI+ LLG C P+ ++ EY KG+L EYLRA +
Sbjct: 417 SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----PGM 472
Query: 454 EHR-EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIAD 512
E+ + Q+A GM YL+ +K +HRDLA RN L+ ++ V+KIAD
Sbjct: 473 EYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 532
Query: 513 FGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY 572
FGL+ I DYYK + +PV+WM E++ YT +SDVW++GV +WEIF+ PY
Sbjct: 533 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 592
Query: 573 FGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
G+ EE+ + LK+ + + P N +Y +M+ CW+ PS RP F+ + + LD I
Sbjct: 593 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 648
>UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to CG8250-PA
- Tribolium castaneum
Length = 1284
Score = 203 bits (496), Expect = 1e-50
Identities = 120/352 (34%), Positives = 175/352 (49%), Gaps = 30/352 (8%)
Query: 289 IALLCHYIVKNHYSK--CNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQLNPKLE------ 340
+A +C +I+ N Y + R+ L D+ LD+L +A + + NP E
Sbjct: 751 VAFIC-FILYNRYQHQASGILRRKMLSGADLQLDRL--RVASDSMMTEYNPNYEFGGVVY 807
Query: 341 ----KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLD 396
+ PR + ++ LGQGAFG V+Q D VAVK L + ++ ++D
Sbjct: 808 TLKDLKDIPREQLRLVKALGQGAFGEVYQGFYRQRPCDTVEMPVAVKTLPEMSTSQAEMD 867
Query: 397 FEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
F EA +++ F+HPNIV +GVC P ++ E + GDL +LR P R
Sbjct: 868 FLMEALIMSKFNHPNIVHFIGVCFDKHPRFIVLELLAGGDLKNFLRESR------PKPER 921
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDD---MVVKIADF 513
IA +A G YL D +F+HRD+A RNCL+ VVKIADF
Sbjct: 922 ------GSPLTMKDLVLIAVDVAKGCKYLEDNRFIHRDIAARNCLLTTKGPGRVVKIADF 975
Query: 514 GLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYF 573
G+S +Y DYY+ +P++WMP E+ L +T ++DVW++GV LWEI S PY
Sbjct: 976 GMSRDVYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGVLLWEIMSMGYMPYT 1035
Query: 574 GMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
G + EV++ + L P N P +Y +M QCW+ P RP F I + L
Sbjct: 1036 GCANREVMQLVTSGGRLDPPANCPGPIYGIMTQCWHPTPEQRPTFATILERL 1087
>UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7223-PA, isoform A - Tribolium castaneum
Length = 861
Score = 202 bits (494), Expect = 2e-50
Identities = 104/291 (35%), Positives = 166/291 (57%), Gaps = 4/291 (1%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E PR+ + + LG+GAFG+V +A+A GL+ ++VAVKMLK+ + + +D E
Sbjct: 527 EIPRSMLCLGKSLGEGAFGKVVKAEAVGLLKPGASSIVAVKMLKEGHTDNEMMDLVSEME 586
Query: 403 LLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
++ H NI+ LLG C G P+ ++ EY G+L ++LR + + P E
Sbjct: 587 MMKMIGKHNNIINLLGCCTQGGPLYVVVEYAPYGNLRDFLRQHRPSSGYEPAIGLEEKEK 646
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL 521
A Q+A GM YL+ R+ +HRDLA RN L++DD +KIADFGL+ I+
Sbjct: 647 KTLTQKDLVS--FAYQVARGMEYLASRRCIHRDLAARNVLVSDDYFLKIADFGLARDIHC 704
Query: 522 QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGM-THEEV 580
DYY+ +PV+WM E++ + YT +SDVW+YG+ LWEI + PY + + E++
Sbjct: 705 NDYYRKTTDGRLPVKWMAPEALFHRVYTTQSDVWSYGILLWEIMTLGGTPYPSVPSVEKL 764
Query: 581 VRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLI 631
+ L++ + + P +Y LM++CW++ P++RP F + + LD I I
Sbjct: 765 FQLLRNGHRMEKPPCCSLEIYMLMRECWSYKPNERPTFSQLVEDLDRILTI 815
>UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690;
n=3; Danio rerio|Rep: hypothetical protein LOC553690 -
Danio rerio
Length = 981
Score = 202 bits (494), Expect = 2e-50
Identities = 104/289 (35%), Positives = 160/289 (55%), Gaps = 14/289 (4%)
Query: 341 KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFERE 400
KL+FPR+N+ I LG+G FG V AKA DEE T+V VK L+ +Q+DF RE
Sbjct: 700 KLQFPRSNLHTITTLGKGEFGEVLLAKAKAA-EDEEETVVLVKSLQTR-DEQMQMDFRRE 757
Query: 401 ACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXX 460
+ A H N+ +LLG+C P ++ EY GDL +YLR + V+
Sbjct: 758 CDMFAKLSHSNVARLLGICREVEPHYMIMEYTDMGDLKQYLRVSKSKDEKVKVQP----- 812
Query: 461 XXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIY 520
+ Q+A GM +LS+++FVH+DLA RNCLI+ +K++ GLS +Y
Sbjct: 813 -----LSTKQKVSVCLQVARGMEHLSNQRFVHKDLAARNCLISSKRQIKVSSLGLSKDVY 867
Query: 521 LQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEV 580
+YY + IP+RW+P E++ + ++ ++DVW++ V +WE+FSF PY + ++V
Sbjct: 868 SSEYYHYRQ-SYIPLRWLPSEAVFEDDFSTKTDVWSFAVLMWEVFSFGEMPYADLADDKV 926
Query: 581 VRFLKDENVLAC-PDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ L+D + C P P V+ LM +CW +P DR +F I L ++
Sbjct: 927 LEALQDGKLKLCPPQGCPSRVFKLMVRCWAASPKDRLSFSEICSALSDL 975
>UniRef50_Q9Y1Y8 Cluster: Protein tyrosine kinase; n=2; Metazoa|Rep:
Protein tyrosine kinase - Ephydatia fluviatilis
Length = 985
Score = 202 bits (494), Expect = 2e-50
Identities = 125/333 (37%), Positives = 182/333 (54%), Gaps = 30/333 (9%)
Query: 316 DIDLDKLPSNLAYHTTGAQLNPK-LEKLEFPR----NNIIYIRDLGQGAFGRVFQAKAPG 370
D+D + L T +P L K E P N+ +R LG G FG V A+
Sbjct: 651 DVDATTASNELLAPYTSIYADPHPLTKAEGPLIVGPQNVREVRPLGVGQFGHVILAETVN 710
Query: 371 L-IPDEEFT----------LVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVC 419
L + D + + LVA+K LKD A FE+E ++ +H N+V++LGVC
Sbjct: 711 LSLKDLKMSATNDDKRVCVLVAMKKLKDGADSTTLEAFEKEIKFMSRLNHENVVRVLGVC 770
Query: 420 AIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIA 479
+ R ++ EYM GDL++YL T FAP +A QIA
Sbjct: 771 PV-RSAFIMMEYMENGDLSQYL----TKYEFAP----PGVCIGQLMLPASTLVHMALQIA 821
Query: 480 SGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMP 539
+GM YL++R F+HRDLATRNCL+ VVKIADFG+S +Y DYYK +P+RWM
Sbjct: 822 AGMRYLAERNFIHRDLATRNCLVGAKYVVKIADFGMSRSLYSNDYYKLRGRAMLPIRWMA 881
Query: 540 LESILYNKYTLESDVWAYGVCLWEIFSFA-LQPYFGMTHEEVVRFLKDEN---VLACPDN 595
E Y K++ ++DVWA+GV +WEIF+F+ QPY M+ ++V+ +++ +LA P N
Sbjct: 882 KE-CFYGKFSQKTDVWAFGVVMWEIFTFSKRQPYDEMSDQQVIENAIEKSGRILLARPHN 940
Query: 596 TPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P+ VY++M QCW ++P R F ++Q+L +I
Sbjct: 941 CPKEVYEVMLQCWENDPETRATFEELFQSLTSI 973
>UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3
precursor; n=30; Tetrapoda|Rep: Tyrosine-protein kinase
receptor TYRO3 precursor - Homo sapiens (Human)
Length = 890
Score = 202 bits (494), Expect = 2e-50
Identities = 124/304 (40%), Positives = 167/304 (54%), Gaps = 26/304 (8%)
Query: 334 QLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDE--ASH 391
+L KLE + P R LG+G FG V +A+ D F VAVKMLK + AS
Sbjct: 503 ELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQ--EDGSFVKVAVKMLKADIIASS 560
Query: 392 DLQLDFEREACLLADFDHPNIVKLLGVC----AIGR---PMCLLFEYMGKGDLNEYLRAC 444
D++ +F REA + +FDHP++ KL+GV A GR PM +L +M GDL+ +L A
Sbjct: 561 DIE-EFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVIL-PFMKHGDLHAFLLAS 618
Query: 445 STVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIND 504
+ P IA GM YLS R F+HRDLA RNC++ +
Sbjct: 619 RIGEN--PFN-----------LPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAE 665
Query: 505 DMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEI 564
DM V +ADFGLS KIY DYY+ +PV+W+ LES+ N YT++SDVWA+GV +WEI
Sbjct: 666 DMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEI 725
Query: 565 FSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQT 624
+ PY G+ + E+ +L N L P VYDLM QCW+ +P RP+F +
Sbjct: 726 MTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRME 785
Query: 625 LDNI 628
L+NI
Sbjct: 786 LENI 789
>UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1
precursor; n=33; Euteleostomi|Rep: Fibroblast growth
factor receptor 1 precursor - Xenopus laevis (African
clawed frog)
Length = 812
Score = 202 bits (494), Expect = 2e-50
Identities = 114/296 (38%), Positives = 165/296 (55%), Gaps = 8/296 (2%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDE--EFTLVAVKMLKDEASHDLQ 394
P+ + E R+ +I + LG+G FG+V A+A GL ++ + T VAVKMLK +AS
Sbjct: 460 PEDPRWEVARDRLILGKPLGEGCFGQVVMAEAIGLDKEKPNKVTKVAVKMLKSDASEKDL 519
Query: 395 LDFEREACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPV 453
D E ++ H NI+ LLG C P+ ++ EY KG+L EYLRA +
Sbjct: 520 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTSKGNLREYLRARRPPA----M 575
Query: 454 EH-REXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIAD 512
E+ A Q+A GM YL+ +K +HRDLA RN L+ +D ++KIAD
Sbjct: 576 EYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLASKKCIHRDLAARNVLVTEDNIMKIAD 635
Query: 513 FGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY 572
FGL+ I+ DYYK + +PV+WM E++ YT +SDVW++GV LWEIF+ PY
Sbjct: 636 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 695
Query: 573 FGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
G+ EE+ + LK+ + + P N +Y +MK CW+ PS RP F + + LD I
Sbjct: 696 PGVPMEELFKLLKEGHRMDKPTNCTNELYMMMKDCWHAMPSQRPTFNQLVEDLDRI 751
>UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1;
Geodia cydonium|Rep: Tyrosine-protein kinase receptor -
Geodia cydonium (Sponge)
Length = 570
Score = 202 bits (492), Expect = 3e-50
Identities = 103/292 (35%), Positives = 162/292 (55%), Gaps = 9/292 (3%)
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
L+ L + +I LG+GAFGRV++ D+ VA+K LKD + + +F
Sbjct: 259 LKGLLLAEDQLILTESLGEGAFGRVYKGSMKTGDDDDRTVEVAIKTLKDISQQENIDNFV 318
Query: 399 REACLLADFDHPNIVKLLGVC--AIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
+E+ L+ F+HPN+++LLGVC R ++ +M GDL YL + + H
Sbjct: 319 QESILMLGFNHPNVLELLGVCFDTTDRHPLIVLPFMANGDLRSYLMSKRDPSVTTKFTH- 377
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
+ ++A GM YLS+ FVHRDLA RNC+++ ++ V++ADFGLS
Sbjct: 378 -----FPQGLDEERALVMCLEVARGMEYLSNSSFVHRDLAARNCMVSGELTVRVADFGLS 432
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
+Y +DYY+ +PV+WM ES+ N +T++SDVW++GV WE+FS + PY G+
Sbjct: 433 RDVYSKDYYRMGTKTMLPVKWMAPESLADNIFTVKSDVWSFGVVCWEVFSL-VAPYPGIG 491
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ E+ ++ L P PR +Y+LM+QCWN + RPNF + L+ +
Sbjct: 492 NHEMSDYIGGGRRLKIPRLCPREIYELMEQCWNEESNKRPNFSELVSQLERV 543
>UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor
precursor; n=8; Eumetazoa|Rep: Putative insulin-like
peptide receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 1477
Score = 201 bits (491), Expect = 4e-50
Identities = 109/288 (37%), Positives = 161/288 (55%), Gaps = 14/288 (4%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E R I IR+LGQG+FG VF+ A G I D VAVK + AS ++ +
Sbjct: 1035 DEWELNREKIELIRELGQGSFGMVFEGIAHG-IGDHAELRVAVKTTNENASIHDRIQILQ 1093
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ F+ ++VKL+GV + G+P ++ E MG+GDL YL+ P+ +E
Sbjct: 1094 EASIMKAFNCNHVVKLIGVVSQGQPTFVVMELMGRGDLKSYLKERRPDDGGIPLMRQEIY 1153
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ +IA GM YL+ RKFVH DLA RNC++ D VKI DFG++ I
Sbjct: 1154 Q-------------MVAEIADGMAYLAARKFVHCDLAARNCMVASDFTVKIGDFGMARDI 1200
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y ++YY+ D +P+RWM ES+ ++ SDVW++GV LWEI + A QPY G T+E+
Sbjct: 1201 YERNYYRKDGKSLLPIRWMAPESLKDGIFSTASDVWSFGVVLWEICTLASQPYQGKTNEQ 1260
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
V+ F+ L P+ + + M CW+ +P RP+F I L+N
Sbjct: 1261 VLNFVLSNGHLDYPEGCDYQLREFMSLCWHRDPKMRPSFLEIVHVLEN 1308
>UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14764,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 635
Score = 200 bits (488), Expect = 9e-50
Identities = 110/290 (37%), Positives = 165/290 (56%), Gaps = 8/290 (2%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDE--EFTLVAVKMLKDEASHDLQLDFERE 400
E PR+ + + LG+G FG+V A+A GL ++ T VAVKMLK +A+ + D E
Sbjct: 342 ELPRDRLTLGKPLGEGCFGQVVLAEAVGLDKNKPARVTKVAVKMLKADATEKDRADLISE 401
Query: 401 ACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
++ H NI+ LLG C P+ +L EY KG+L +YLRA A +E+
Sbjct: 402 MEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLRDYLRARRP----AGLEYWSSS 457
Query: 460 X-XXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
A Q+A GM YL+ +K +HRDLA RN L+ +D V+KIADFGL+
Sbjct: 458 RPVSLASMEIMELVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 517
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
++ DYYK + +PV+WM E++ YT +SDVW++GV LWEIF+ PY G+ E
Sbjct: 518 VHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 577
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
E+ + LK+ + + P + + +Y +M+ CW+ P+ RP F+ + + LD I
Sbjct: 578 ELFKLLKEGHRMEKPPTSTQELYLMMRGCWHAVPARRPTFQQLVEDLDRI 627
>UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3;
Eutheria|Rep: HOOK3-RET fusion protein - Homo sapiens
(Human)
Length = 776
Score = 200 bits (488), Expect = 9e-50
Identities = 111/295 (37%), Positives = 154/295 (52%), Gaps = 5/295 (1%)
Query: 341 KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFERE 400
K EFPR N++ + LG+G FG+V +A A L +T VAVKMLK+ AS D E
Sbjct: 378 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 437
Query: 401 ACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVT-----SFAPVEH 455
+L +HP+++KL G C+ P+ L+ EY G L +LR V S
Sbjct: 438 FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 497
Query: 456 REXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGL 515
A QI+ GM YL++ K VHRDLA RN L+ + +KI+DFGL
Sbjct: 498 SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 557
Query: 516 SHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGM 575
S +Y +D Y IPV+WM +ES+ + YT +SDVW++GV LWEI + PY G+
Sbjct: 558 SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 617
Query: 576 THEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQL 630
E + LK + + PDN +Y LM QCW P RP F I + L+ + +
Sbjct: 618 PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMV 672
>UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase
receptor ret precursor; n=59; Eumetazoa|Rep:
Proto-oncogene tyrosine-protein kinase receptor ret
precursor - Homo sapiens (Human)
Length = 1114
Score = 200 bits (488), Expect = 9e-50
Identities = 111/295 (37%), Positives = 154/295 (52%), Gaps = 5/295 (1%)
Query: 341 KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFERE 400
K EFPR N++ + LG+G FG+V +A A L +T VAVKMLK+ AS D E
Sbjct: 716 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775
Query: 401 ACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVT-----SFAPVEH 455
+L +HP+++KL G C+ P+ L+ EY G L +LR V S
Sbjct: 776 FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835
Query: 456 REXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGL 515
A QI+ GM YL++ K VHRDLA RN L+ + +KI+DFGL
Sbjct: 836 SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895
Query: 516 SHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGM 575
S +Y +D Y IPV+WM +ES+ + YT +SDVW++GV LWEI + PY G+
Sbjct: 896 SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955
Query: 576 THEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQL 630
E + LK + + PDN +Y LM QCW P RP F I + L+ + +
Sbjct: 956 PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMV 1010
>UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor
precursor; n=8; Amniota|Rep: Leukocyte tyrosine kinase
receptor precursor - Mus musculus (Mouse)
Length = 888
Score = 199 bits (486), Expect = 2e-49
Identities = 104/281 (37%), Positives = 148/281 (52%), Gaps = 15/281 (5%)
Query: 348 NIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADF 407
N+ +R LG GAFG V++ GL D VA+K L + SH +LDF EA +++ F
Sbjct: 505 NVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKF 564
Query: 408 DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXX 467
H NIV+ +G+ P +L E M GD+ +LR H
Sbjct: 565 SHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLR------------HSRPHPGQLAPLT 612
Query: 468 XXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN---DDMVVKIADFGLSHKIYLQDY 524
+A+ IA G YL + F+HRD+A RNCL++ V KI DFG++ IY Y
Sbjct: 613 MQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASY 672
Query: 525 YKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFL 584
Y+ +PV+WMP E++L +T ++D W++GV LWEIFS PY G T++EV+ F+
Sbjct: 673 YRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFI 732
Query: 585 KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
N + P N P VY +M QCW H P RP+F I + +
Sbjct: 733 ATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERI 773
>UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=15; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Abelson murine leukemia virus
Length = 746
Score = 199 bits (486), Expect = 2e-49
Identities = 108/294 (36%), Positives = 168/294 (57%), Gaps = 25/294 (8%)
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ 394
++P +K E R +I LG G +G V++ G+ T VAVK LK++ +++
Sbjct: 114 VSPNYDKWEMERTDITMKHKLGGGQYGEVYE----GVWKKYSLT-VAVKTLKEDTM-EVE 167
Query: 395 LDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
+F +EA ++ + HPN+V+LLGVC P ++ E+M G+L +YLR C+ A V
Sbjct: 168 -EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVV- 225
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
+A QI+S M YL + F+HRDLA RNCL+ ++ +VK+ADFG
Sbjct: 226 ----------------LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 269
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
LS ++ D Y P++W ES+ YNK++++SDVWA+GV LWEI ++ + PY G
Sbjct: 270 LS-RLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 328
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ +V L+ + + P+ P VY+LM+ CW NPSDRP+F I+Q + +
Sbjct: 329 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM 382
>UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG14396-PA, isoform A - Tribolium castaneum
Length = 1065
Score = 199 bits (485), Expect = 2e-49
Identities = 109/288 (37%), Positives = 153/288 (53%), Gaps = 9/288 (3%)
Query: 341 KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFERE 400
K EFPRN +I + LG+G FG+V +AKA + T VAVK LKD+A D E
Sbjct: 735 KWEFPRNRLIIEQTLGEGEFGKVLRAKALNISGQPGLTTVAVKTLKDDARESELNDLLSE 794
Query: 401 ACLLADFDHPNIVKLLGVC-AIGRPMCLLFEYMGKGDLNEYLRA-------CSTVTSFAP 452
LL + HPN+++LLGVC A G P+ L+ E+ G L YLR C + S
Sbjct: 795 YQLLKEVSHPNVIRLLGVCTAPGGPIYLIIEFAEHGSLRNYLRRSRHLKSECGRLPSSTV 854
Query: 453 VEHR-EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIA 511
E+ A QI GM YLS+ K VHRDLA RN L+ D + KI+
Sbjct: 855 DENDVHYDEPNISKVTPKEILSFAWQICKGMAYLSEIKLVHRDLAARNVLLAADQICKIS 914
Query: 512 DFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQP 571
DFGL+ IY D Y +PV+WM ES+ + YT +SDVW++G+ +WE+ + P
Sbjct: 915 DFGLTRDIYEDDAYFKRSKGRVPVKWMAPESLSDHIYTNKSDVWSFGILVWELVTLGATP 974
Query: 572 YFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
Y G+ + + L+ + PDN +Y++M+ CW+ +P RP F+
Sbjct: 975 YPGIAVQNLFHLLRQGYRMERPDNCSPTLYNIMRSCWHIDPEQRPTFQ 1022
>UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2
precursor; n=11; Eumetazoa|Rep: Fibroblast growth factor
receptor 2 precursor - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 817
Score = 199 bits (485), Expect = 2e-49
Identities = 110/296 (37%), Positives = 164/296 (55%), Gaps = 8/296 (2%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDE--EFTLVAVKMLKDEASHDLQ 394
P+ + EF R+ + + LG+G FG+V A+A G+ D+ E VAVKMLKD+A+
Sbjct: 465 PEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDL 524
Query: 395 LDFEREACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPV 453
D E ++ H NI+ LLG C P+ ++ EY KG+L EYLRA +
Sbjct: 525 SDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----PGM 580
Query: 454 EHR-EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIAD 512
E+ + Q+A GM YL+ +K +HRDLA RN L+ + V+KIAD
Sbjct: 581 EYSYDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIAD 640
Query: 513 FGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY 572
FGL+ ++ DYYK + +PV+WM E++ YT +SDVW++GV +WEIF+ PY
Sbjct: 641 FGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 700
Query: 573 FGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
G+ EE+ + LK+ + + P N +Y +MK CW+ S RP F+ + + LD I
Sbjct: 701 PGIPVEELFKLLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDLDRI 756
>UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase
ABL1; n=35; root|Rep: Proto-oncogene tyrosine-protein
kinase ABL1 - Homo sapiens (Human)
Length = 1130
Score = 199 bits (485), Expect = 2e-49
Identities = 108/294 (36%), Positives = 168/294 (57%), Gaps = 25/294 (8%)
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ 394
++P +K E R +I LG G +G V++ G+ T VAVK LK++ +++
Sbjct: 228 VSPNYDKWEMERTDITMKHKLGGGQYGEVYE----GVWKKYSLT-VAVKTLKEDTM-EVE 281
Query: 395 LDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
+F +EA ++ + HPN+V+LLGVC P ++ E+M G+L +YLR C+ A V
Sbjct: 282 -EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVV- 339
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
+A QI+S M YL + F+HRDLA RNCL+ ++ +VK+ADFG
Sbjct: 340 ----------------LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 383
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
LS ++ D Y P++W ES+ YNK++++SDVWA+GV LWEI ++ + PY G
Sbjct: 384 LS-RLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 442
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ +V L+ + + P+ P VY+LM+ CW NPSDRP+F I+Q + +
Sbjct: 443 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM 496
>UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine
protein kinase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to tyrosine protein kinase -
Strongylocentrotus purpuratus
Length = 1566
Score = 198 bits (484), Expect = 3e-49
Identities = 107/287 (37%), Positives = 158/287 (55%), Gaps = 8/287 (2%)
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
L++ E PR N++ R LG+GAFG V+ +A L+ D ++ VAVK LK AS + +LDF
Sbjct: 1010 LDEWEMPRENVVLNRKLGEGAFGTVYGGEA--LLDDNKWAAVAVKTLKLGASVEEKLDFL 1067
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
EA ++ F+H NIV LLGVC G PM + E+M GDL +L + E +
Sbjct: 1068 SEAEVMKRFNHKNIVNLLGVCTRGEPMYAVMEFMLYGDLKTFLLGRRHLVGEGVYERNQH 1127
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
+ IASG+ YL+ +VHRDLA RNCL++ VKI DFG++
Sbjct: 1128 VMCPDQLTS------MVSDIASGLSYLASINYVHRDLACRNCLVDASYTVKIGDFGMTRA 1181
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
+Y DYY+ + +PVRWM ES+ +T SDVW+ GV ++E+ +F PY +++
Sbjct: 1182 LYDSDYYRLGKRSKLPVRWMAPESLTEGIFTTMSDVWSLGVVIYEVVTFGSFPYQELSNA 1241
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
EV+ ++++ N L P+ + LM QCW P RP + + L
Sbjct: 1242 EVLDYIRNRNSLRPPEGCSPALGALMMQCWAIQPQHRPTAKDVNDIL 1288
>UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor b - Nematostella vectensis
Length = 591
Score = 198 bits (482), Expect = 5e-49
Identities = 114/308 (37%), Positives = 170/308 (55%), Gaps = 9/308 (2%)
Query: 321 KLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTL- 379
+L SNL+ + +L P E+ E R+ I + LG+GAFGRV +A A GL P+ +
Sbjct: 248 RLGSNLS-QVSEIEL-PLDEEWELDRSQISLLGILGEGAFGRVVKADAIGL-PNMPYRCN 304
Query: 380 VAVKMLKDEASHDLQLDFEREACLLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLN 438
VAVKML ++A+ D E ++ H NI+ L+G C P+ ++ EY +G+L
Sbjct: 305 VAVKMLXEDATEHELADLVSEMEVMKTIGQHVNIINLIGACTQKGPLFVVVEYASQGNLR 364
Query: 439 EYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATR 498
++LRA + +A + Q+A GM YL +K +HRDLA R
Sbjct: 365 QFLRARRPIPEYA----NPLTEPPREKLKLVDLVSFSYQVARGMEYLESKKCIHRDLAAR 420
Query: 499 NCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYG 558
N L++D+ V+KIADFGL+ I+ DYY+ +PV+WM LE++ YT +SDVWAYG
Sbjct: 421 NVLVSDNHVIKIADFGLARDIHDIDYYRKTTDGRLPVKWMALEALFDRVYTAQSDVWAYG 480
Query: 559 VCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
+ +WEI +F PY G+ ++ LK+ + P N VY LM +CW+ NP+ RP F
Sbjct: 481 ILMWEIVTFGGSPYPGIPLWKLFELLKEGYRMEQPVNCQDDVYALMLRCWHENPNQRPTF 540
Query: 619 RVIYQTLD 626
I + +D
Sbjct: 541 AEIVKEMD 548
>UniRef50_A1IKE0 Cluster: Receptor tyrosine kinase-like orphan
receptor; n=2; Nematostella vectensis|Rep: Receptor
tyrosine kinase-like orphan receptor - Nematostella
vectensis
Length = 715
Score = 197 bits (481), Expect = 6e-49
Identities = 101/281 (35%), Positives = 157/281 (55%), Gaps = 7/281 (2%)
Query: 346 RNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEF-TLVAVKMLKDEASHDLQLDFEREACLL 404
+ ++ +++LG+G +G+V+ + T V V L++ D++ +F +A
Sbjct: 436 KESLRLLKELGEGDYGKVYFGEITTKSEGRLMATSVLVVSLRESHEVDVRDEFFEKAEAW 495
Query: 405 ADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXX 464
+ HPNI+ ++G+C P C+L+EY+ G L+EYL AP++ E
Sbjct: 496 SKLQHPNIITIVGMCNKSVPTCVLYEYLEYGTLHEYL------VRNAPIDDPEAEEEIAD 549
Query: 465 XXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDY 524
IA Q+A+GM YLS VH DLATRNC++ VKI D L+ Y DY
Sbjct: 550 PLWCDGLISIAYQVAAGMNYLSSNNIVHGDLATRNCMVGPGRTVKITDVALTRLGYSHDY 609
Query: 525 YKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFL 584
Y+ +PVRWM E+IL ++T E+D+W++GV LWE+FS+ QP+FG ++E+V+ L
Sbjct: 610 YRQLHRRPLPVRWMAPEAILSYRFTPETDIWSFGVLLWELFSYGAQPHFGFSNEDVMFRL 669
Query: 585 KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
++ +L CP + P VY LMK+CW+ P RP F I+ L
Sbjct: 670 RECILLPCPVDCPASVYRLMKECWDILPPSRPRFSTIHTHL 710
Score = 120 bits (288), Expect = 2e-25
Identities = 73/235 (31%), Positives = 101/235 (42%), Gaps = 18/235 (7%)
Query: 20 YCGPYNGQVC-KSY----STGYVWYNHTGGLDNEKITSGLWKEMISNLQEPCRTQAERLL 74
YC Y G +C KS S N G ++ + + L + C+ LL
Sbjct: 143 YCVRYTGHICSKSINHKKSVFISAVNQQGSIEKKLEIAFNTISRSKKLSDSCQPYVLPLL 202
Query: 75 CAYAFPKCINKDGVGYFALPLCYEDCMAVKMQFCYNDWIVIEDQKERGVFFESRGHFRLP 134
C Y FP C + PLCY++C ++ C E+ KE V ES P
Sbjct: 203 CHYLFPYCDDAASQPQ-PRPLCYDECDLLRKDVCS------EEYKE--VQKESLSVVSFP 253
Query: 135 ECENLPHYSGKGSQVSCNNIGITDMDL---DQVTTTCVKGNGRYYQGVINETKAGLACQA 191
+CE LP + C +GI + C G G +Y G I+ T+ G CQ
Sbjct: 254 DCERLPSRDSVQGK-KCIRLGIQTRRAWPKESKGDLCFNGTGEHYNGNISVTEKGFGCQR 312
Query: 192 WESQFPHQHTRPPLVFPEVQNSSNYCRNAGGEENRPWCYTMHPNVRWQYCEIPMC 246
W PH H P + E++ NYCRN GG++ RPWC+T P R+ YC+I C
Sbjct: 313 WNVTTPHFHLMSPATYHELRGGHNYCRNPGGKKQRPWCFTTDPRQRYDYCDIAKC 367
>UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:
ENSANGP00000013218 - Anopheles gambiae str. PEST
Length = 861
Score = 197 bits (480), Expect = 9e-49
Identities = 106/279 (37%), Positives = 145/279 (51%), Gaps = 5/279 (1%)
Query: 341 KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFERE 400
K EFPR N+I LG+G FG+V + A L T VAVKMLK A+ L E
Sbjct: 479 KWEFPRTNLILDATLGEGEFGKVLKGFATDLPEKPGITTVAVKMLKTGANSVELLALLSE 538
Query: 401 ACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXX 460
LL + +HPN+++LLG C G L+ EY G L YLR S ++
Sbjct: 539 YQLLQEVNHPNVIRLLGACTKGDSPLLIIEYCQYGSLKNYLR-LSRKLEVLNADYEN--- 594
Query: 461 XXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIY 520
A QI+ GM YL+D K VHRDLA RN L+ + V KI+DFGL+ +Y
Sbjct: 595 -AVEPITVKDILSFAWQISKGMAYLTDIKLVHRDLAARNVLLAEGKVCKISDFGLTRDVY 653
Query: 521 LQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEV 580
D Y D +PV+WM ES+ + YT +SDVWA+GV WE+ + PY G+ + +
Sbjct: 654 EDDAYLKKSKDRVPVKWMAPESLADHIYTTKSDVWAFGVLCWELITLGASPYPGIPPQNL 713
Query: 581 VRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
LK + CP N +Y +++ CW +P RP+F+
Sbjct: 714 YNLLKQGYRMECPKNCSEEIYGIVRLCWADDPKQRPSFK 752
>UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin
receptor precursor (IR); n=1; Apis mellifera|Rep:
PREDICTED: similar to Insulin receptor precursor (IR) -
Apis mellifera
Length = 1374
Score = 196 bits (479), Expect = 1e-48
Identities = 107/287 (37%), Positives = 159/287 (55%), Gaps = 9/287 (3%)
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
L+K E PR+ ++ R LG+GAFG V+ +A P++ + VAVK LK +S + +LDF
Sbjct: 932 LDKWEIPRHRVVINRKLGEGAFGTVYGGEA--FFPEKGWLAVAVKTLKIGSSTEEKLDFL 989
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
E ++ F+H NI+KLLGVC P+ + E+M GDL YL A + + E +
Sbjct: 990 SEVEVMKQFEHKNIIKLLGVCIKSEPVLTVMEFMLYGDLKTYLLARRHLVNDNSYEDSDE 1049
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
+A +A + YL+ K+VHRD+A+RNCL+N VVK+ DFG++
Sbjct: 1050 ISNKKLTA-------MALDVARALSYLAQSKYVHRDIASRNCLVNAQRVVKLGDFGMTRL 1102
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
+Y DYYK + +PVRWM ES+ ++ SDVW+YGV L+EI +F P+ GM++
Sbjct: 1103 MYENDYYKFNRRGMLPVRWMAPESLGLGIFSPASDVWSYGVLLYEIITFGSFPFQGMSNI 1162
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
EV+ +K N L P + +LM CW + RP I + L
Sbjct: 1163 EVLNHVKSGNSLMVPKGVKIQLENLMYSCWRLDHIKRPTAPEIVEFL 1209
>UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1 - Nasonia
vitripennis
Length = 1522
Score = 196 bits (478), Expect = 1e-48
Identities = 107/294 (36%), Positives = 164/294 (55%), Gaps = 25/294 (8%)
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ 394
L+P+ ++ E R +I+ LG G +G V++A + VAVK LK++
Sbjct: 276 LSPEPDEWEINRTDIVMRHKLGGGQYGDVYEA-----VWKRYNMTVAVKTLKEDTM--AL 328
Query: 395 LDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
DF EA ++ + H N+V+L+GVC P ++ E+M KG+L +YLR S +
Sbjct: 329 KDFLEEAAIMKEMKHRNLVQLIGVCTREPPFYIITEFMSKGNLLDYLRNES--------K 380
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
H+ +A QIASGM YL R F+HRDLA RNCL+ + +VK+ADFG
Sbjct: 381 HQ---------INAVVLMHMATQIASGMSYLESRNFIHRDLAARNCLVGESHLVKVADFG 431
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
L+ ++ D Y P++W E + YNK++ +SDVWA+G+ LWEI ++ + PY G
Sbjct: 432 LA-RLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPG 490
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ +V L+ + CP P VY+LM+QCW + SDRP F+ I+ +L+N+
Sbjct: 491 VDLTDVYHMLEKGYRMECPPGCPPKVYELMRQCWQWSASDRPTFKEIHHSLENM 544
>UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosine
kinase CG4032-PA; n=1; Apis mellifera|Rep: PREDICTED:
similar to Abl tyrosine kinase CG4032-PA - Apis
mellifera
Length = 1439
Score = 196 bits (478), Expect = 1e-48
Identities = 107/294 (36%), Positives = 165/294 (56%), Gaps = 25/294 (8%)
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ 394
L+P+ ++ E R +I+ LG G +G V++A + VAVK LK++
Sbjct: 275 LSPEPDEWEINRTDIVMRHKLGGGQYGDVYEA-----VWKRYNMTVAVKTLKEDTM--AL 327
Query: 395 LDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
DF EA ++ + H N+V+LLGVC P ++ E+M KG+L +YLR S +
Sbjct: 328 KDFLEEAAIMKEMKHRNLVQLLGVCTREPPFYIITEFMSKGNLLDYLRNES--------K 379
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
H+ +A QIASGM YL R F+HRDLA RNCL+ ++ +VK+ADFG
Sbjct: 380 HQ---------INAVVLMHMATQIASGMSYLESRNFIHRDLAARNCLVGENHLVKVADFG 430
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
L+ ++ D Y P++W E + YNK++ +SDVWA+G+ LWEI ++ + PY G
Sbjct: 431 LA-RLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPG 489
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ +V L+ + CP P VY+LM+QCW + +DRP F+ I+ +L+N+
Sbjct: 490 VDLTDVYHMLEKGYRMECPPGCPPKVYELMRQCWQWSAADRPTFKEIHHSLENM 543
>UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca
precursor; n=2; Diptera|Rep: Tyrosine kinase receptor
Cad96Ca precursor - Drosophila melanogaster (Fruit fly)
Length = 773
Score = 196 bits (478), Expect = 1e-48
Identities = 100/290 (34%), Positives = 157/290 (54%), Gaps = 7/290 (2%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ EFPR + + LG+GAFG+V++ +A + +E T VAVK LK+ A+ + D
Sbjct: 461 DRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLS 520
Query: 400 EACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
E ++ + H N+V LLG C P ++ EY+ +G L YLR S H
Sbjct: 521 ELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLR------SSRAERHYGN 574
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
Q+A GM YL+ R +HRDLA RN LI DD K+ADFG +
Sbjct: 575 THGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARD 634
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
+ Y+ +P+RWM ES+ N ++++SD+W++G+ +WEI + PY G++
Sbjct: 635 VITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAA 694
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+V+R ++D L P++ R +Y++M CW+H+P +RP F I Q LD +
Sbjct: 695 DVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKL 744
>UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK splice
variant A; n=9; Diptera|Rep: Receptor protein tyrosine
kinase ALK splice variant A - Drosophila melanogaster
(Fruit fly)
Length = 1701
Score = 195 bits (476), Expect = 3e-48
Identities = 125/394 (31%), Positives = 196/394 (49%), Gaps = 33/394 (8%)
Query: 250 SREKDNIKGSNLIMENYFTPTFVLLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSR 309
S ++DN I E +F L+SI + + IA L +++ N Y + S +
Sbjct: 1082 SLKRDNHTACE-IREEAGKSSFQYLVSILMISLAVLFICIAALI-FMLYNRYQRKKQSKK 1139
Query: 310 RN--LQNMDIDLDKLPSNLA----------YHTTGAQLNPKLEKLEFP---RNNIIYIRD 354
R+ L D+ L +L +N+ Y G LN ++ P R+++ +
Sbjct: 1140 RHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGI-LNGHIDVNSLPQVARDSLQLVNA 1198
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
LG+GAFG V+ A D VAVK L+++ + + DF +EA ++A F+HPN+V
Sbjct: 1199 LGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVH 1258
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L+GVC +P ++ E + GDL ++LR E+R
Sbjct: 1259 LIGVCFDRQPYYIVLELLAGGDLQKFLR-----------ENRNTPERPSLLTMKDLLF-C 1306
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDD---MVVKIADFGLSHKIYLQDYYKGDEHD 531
A +A G Y+ ++F+HRD+A RNCL++ VVKIADFG+S IY DYY+
Sbjct: 1307 ALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKA 1366
Query: 532 AIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLA 591
+P++WMP E+ L +T ++DVW++G+ LWE+FS PY G + +V+ + L
Sbjct: 1367 MLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLG 1426
Query: 592 CPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
P P +Y +M CWN P DRP F + + L
Sbjct: 1427 SPTECPVSIYKVMADCWNPTPEDRPTFITLLEHL 1460
>UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4;
Endopterygota|Rep: Tyrosine-protein kinase - Aedes
aegypti (Yellowfever mosquito)
Length = 959
Score = 195 bits (475), Expect = 3e-48
Identities = 109/289 (37%), Positives = 160/289 (55%), Gaps = 6/289 (2%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKD-EASHDLQ-LDFERE 400
EFPR+ ++ + LG+GAFG+V A+A GL+ + T+VAVKMLK+ D++ L E E
Sbjct: 620 EFPRSKLVLGKSLGEGAFGKVVMAEANGLVKGQASTVVAVKMLKEGHTDADVKDLVCEME 679
Query: 401 ACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXX 460
+ H NI+ LLG C P+ ++ EY G+L ++LR+ T A E
Sbjct: 680 VMKMIG-KHVNIINLLGCCCKDGPLYVIVEYAPHGNLKDFLRSHRFGT--ANYEDMISGE 736
Query: 461 XXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIY 520
A QIA GM +L+ R+ +HRDLA RN L++D V+KIADFGL+ I+
Sbjct: 737 KEKKILTQKELISFAYQIARGMEHLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIH 796
Query: 521 LQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGM-THEE 579
Q+YY+ +P+RWM ES+ Y +SDVW++GV LWEI + PY + T +
Sbjct: 797 SQEYYRKTTTGKLPIRWMAPESLEEKFYDSQSDVWSFGVLLWEIMTLGGNPYSSIPTWDN 856
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
++ LK L P +Y M++CW++ P +RP F I Q LD +
Sbjct: 857 LLEHLKKGKRLEQPPLCSIDIYLFMRECWHYRPEERPTFSEIVQHLDRL 905
>UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=57; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Feline sarcoma virus (strain
Hardy-Zuckerman 2)
Length = 439
Score = 195 bits (475), Expect = 3e-48
Identities = 107/288 (37%), Positives = 164/288 (56%), Gaps = 25/288 (8%)
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ 394
++P +K E R +I LG G +G V++ G+ T VAVK LK++ +++
Sbjct: 177 VSPNYDKWEMERTDITMKHKLGGGQYGEVYE----GVWKKYSLT-VAVKTLKEDTM-EVE 230
Query: 395 LDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
+F +EA ++ + HPN+V+LLGVC P ++ E+M G+L +YLR C+ A V
Sbjct: 231 -EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVV- 288
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
+A QI+S M YL + F+HRDLA RNCL+ ++ +VK+ADFG
Sbjct: 289 ----------------LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 332
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
LS ++ D Y P++W ES+ YNK++++SDVWA+GV LWEI ++ + PY G
Sbjct: 333 LS-RLMTGDTYTAHAGTKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 391
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIY 622
+ +V L+ + + P+ P VY+LM+ CW NPSDRP F I+
Sbjct: 392 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPAFAEIH 439
>UniRef50_UPI00015B629F Cluster: PREDICTED: similar to CG33531-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
CG33531-PA - Nasonia vitripennis
Length = 834
Score = 194 bits (474), Expect = 5e-48
Identities = 114/302 (37%), Positives = 162/302 (53%), Gaps = 23/302 (7%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKA---PG---LIPDEEFTLVAVKMLKDEASHDLQLD 396
+FPR + +LG G FG + + PG + + LV VK L+ +S L+++
Sbjct: 533 DFPRERLNIAENLGSGYFGDIHICEVDRFPGYEEVFRNTSSDLVVVKSLRPGSSEVLRIE 592
Query: 397 FEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
F +EA LA + N+ +LLG PMC++ E GDLN+YL+ S V V+
Sbjct: 593 FRQEAKRLARLNDRNVARLLGASLDDDPMCIVLENGEYGDLNQYLQ--SHVAETTTVQ-- 648
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
+A QIASGM YL + FVHRDLATRNCL++ VK++D G
Sbjct: 649 -----TAKTLSFGTLIYMATQIASGMKYLEEMDFVHRDLATRNCLVSQGNHVKVSDLGPG 703
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL-QPYFGM 575
Y DY+K + A+P+RWM ES+L YT +SDVWA+ V WEI +FA QP+ +
Sbjct: 704 RSAYSADYFKIEGRPAMPIRWMAWESMLVGNYTSKSDVWAFAVTFWEILTFAREQPFEEL 763
Query: 576 THEEVVR----FLKDEN---VLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+V F ++++ +L P N P+ +YDLM++CW N SDRPNFR I+ L
Sbjct: 764 PDHRIVENATYFYQEDDRRLILPLPKNCPKEMYDLMRECWQRNDSDRPNFREIHLFLQRK 823
Query: 629 QL 630
L
Sbjct: 824 NL 825
>UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte
receptor tyrosine protein kinase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to leukocyte receptor
tyrosine protein kinase - Nasonia vitripennis
Length = 1472
Score = 194 bits (474), Expect = 5e-48
Identities = 117/369 (31%), Positives = 187/369 (50%), Gaps = 31/369 (8%)
Query: 270 TFVLLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSRRN--------LQNMDIDLDK 321
T +++L I +G ++A +G LC + + ++ + RR L ++ + D
Sbjct: 835 TVMVVLIIVSIGLIIAFSG---LCFLLYNRYQNRKELERRRQVMFGNGTELTSLRVVSDS 891
Query: 322 LPS--NLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTL 379
+ + N Y G + K + + PR+++ ++ LGQGAFG VFQ +E
Sbjct: 892 MMTEFNPNYEFAGNLYSFK-DLPQIPRDSVTLVKPLGQGAFGEVFQGVYKYSRSEEH--P 948
Query: 380 VAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNE 439
VAVK L ++ + DF EA +++ F+HPNIV+ +G+ P ++ E + GDL
Sbjct: 949 VAVKTLPSVSTSQAEADFMMEALIMSKFEHPNIVQFIGISFDKHPRYIVLELLAGGDLKN 1008
Query: 440 YLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRN 499
+LR E R A +A G Y+ + +F+HRD+A RN
Sbjct: 1009 FLR-----------EERPRPDRPTTLTMQSLIM-CAYDVAKGCKYMEEARFIHRDIAARN 1056
Query: 500 CLIN---DDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWA 556
CL++ VVKIADFG++ IY DYY+ +P++WMP ES L +T ++DVWA
Sbjct: 1057 CLLSCKGPGRVVKIADFGMARDIYRSDYYRKGGKAMLPIKWMPPESFLDGIFTTKTDVWA 1116
Query: 557 YGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRP 616
+GV LWEI SF PY G + EV+ + L P P +Y +M +CW+ +P +RP
Sbjct: 1117 FGVLLWEIMSFGYMPYTGCANREVMSMVTSGGRLERPAGCPDPIYGIMTRCWHPHPEERP 1176
Query: 617 NFRVIYQTL 625
+F I + +
Sbjct: 1177 SFSSIVERI 1185
>UniRef50_UPI0000E468FC Cluster: PREDICTED: similar to KLG; n=3;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
KLG - Strongylocentrotus purpuratus
Length = 1013
Score = 194 bits (474), Expect = 5e-48
Identities = 109/290 (37%), Positives = 160/290 (55%), Gaps = 12/290 (4%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
+KL+FP++++ I +G GA+G V ++A G+ EE T V VK L+ + LQLDF R
Sbjct: 729 DKLQFPKHDMQTITTIGHGAYGEVTLSRAAGIKDGEEATTVMVKALETK-EESLQLDFRR 787
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
E +L +H NIVKLLGVC P ++ EY+ GDL ++L+A V
Sbjct: 788 EIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDWGDLKQFLQATRGENGTKNVPPP--- 844
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
I Q+A GM LS +F+H DLA RNCL++ M VKI +S +
Sbjct: 845 ------LTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTMSVSQDL 898
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y +Y++ + IPVRWMP E+I ++ + +SDVWAYG+ +WE+FS PY + ++
Sbjct: 899 YRPEYHEYHQK-LIPVRWMPAEAIFEDELSAKSDVWAYGIFVWEVFSQGTLPYTQLDNDA 957
Query: 580 VVRFLKD-ENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
V+R + D E +L P +TP + +M +CW +P DR F I L I
Sbjct: 958 VMRAMIDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHLGRI 1007
>UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 624
Score = 193 bits (471), Expect = 1e-47
Identities = 103/290 (35%), Positives = 151/290 (52%), Gaps = 3/290 (1%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
E E R+ I LG+GAFG V +A+A GL VAVKMLK +A+ + D
Sbjct: 325 EDWEIDRSQITIKEQLGEGAFGLVMKAEALGLTDMPYRHTVAVKMLKADATENELADLLS 384
Query: 400 EACLLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
E + + H NI+ L+G C P+ ++ E+ G+L ++LR S +
Sbjct: 385 EMDTMKNIGSHKNIINLIGACTQNGPLYVVVEFAPHGNLRQFLR--ERRPSDYHRSRSDS 442
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
A QIA GM YLS +K +HRDLA RN L+ +D V+KIADFGL+
Sbjct: 443 STHSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLARN 502
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
+ DYY+ +P++W+ +E++ YT +SDVW +G+ LWEIF+ PY G+ E
Sbjct: 503 VRDMDYYRKATDGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGIPVE 562
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
++ LK + P P +YD+M CWN NP+ RP+F + D +
Sbjct: 563 KLFELLKSGYRMQMPQKCPDKMYDIMLSCWNENPNARPSFTELRAEFDKM 612
>UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor a - Nematostella vectensis
Length = 441
Score = 193 bits (471), Expect = 1e-47
Identities = 103/290 (35%), Positives = 151/290 (52%), Gaps = 3/290 (1%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
E E R+ I LG+GAFG V +A+A GL VAVKMLK +A+ + D
Sbjct: 110 EDWEIDRSQITIKEQLGEGAFGLVMKAEALGLTDMPYRHTVAVKMLKADATENELADLLS 169
Query: 400 EACLLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
E + + H NI+ L+G C P+ ++ E+ G+L ++LR S +
Sbjct: 170 EMDTMKNIGSHKNIINLIGACTQNGPLYVVVEFAPHGNLRQFLR--ERRPSDYHRSRSDS 227
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
A QIA GM YLS +K +HRDLA RN L+ +D V+KIADFGL+
Sbjct: 228 STHSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLARN 287
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
+ DYY+ +P++W+ +E++ YT +SDVW +G+ LWEIF+ PY G+ E
Sbjct: 288 VRDMDYYRKATDGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGIPVE 347
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
++ LK + P P +YD+M CWN NP+ RP+F + D +
Sbjct: 348 KLFELLKSGYRMQMPQKCPDKMYDIMLSCWNENPNARPSFTELRAEFDKM 397
>UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles gambiae str. PEST|Rep: Tyrosine-protein kinase
receptor - Anopheles gambiae str. PEST
Length = 2075
Score = 193 bits (470), Expect = 1e-47
Identities = 111/309 (35%), Positives = 167/309 (54%), Gaps = 21/309 (6%)
Query: 324 SNLAYHTTGAQLNPKLEKLEFPRNNIIYIRD---LGQGAFGRVFQAKAPGLIPDEEFTLV 380
+N+ Y ++G+ + ++ L R + I++ LG GAFG V++ G+ + E T V
Sbjct: 1778 TNILY-SSGSMTDSEIALLPRIRLDQIFMASSSLLGSGAFGEVYEGVVKGVDGEAE-TRV 1835
Query: 381 AVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEY 440
A+K LK A + +F +EA L+++F H +I +LLGVC + ++ E M GDL Y
Sbjct: 1836 AIKTLKKGAKLHEKQEFLQEAQLMSNFKHKHITRLLGVCLEADALLIIMELMQGGDLLSY 1895
Query: 441 LRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNC 500
LR ++ A + + +ASG YL + FVHRDLA RNC
Sbjct: 1896 LRRSRSLPGQA------------ARLTMLDLISMCQDVASGCRYLEEMHFVHRDLACRNC 1943
Query: 501 LIND----DMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWA 556
L++ D VVKI DFGL+ IY DYY+ + +PVRWM ES++ +T +SD+WA
Sbjct: 1944 LVSSTDPRDRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWA 2003
Query: 557 YGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRP 616
+GV LWEI + QPY + EV+ +++ L P P +Y+LMK CW +P +RP
Sbjct: 2004 FGVLLWEIMTLGEQPYQAKNNVEVLNHVREGGHLDRPKVCPNEMYELMKYCWKFSPEERP 2063
Query: 617 NFRVIYQTL 625
FR + L
Sbjct: 2064 TFRYCLEVL 2072
>UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ROS
precursor; n=20; Eumetazoa|Rep: Proto-oncogene
tyrosine-protein kinase ROS precursor - Homo sapiens
(Human)
Length = 2347
Score = 193 bits (470), Expect = 1e-47
Identities = 109/306 (35%), Positives = 161/306 (52%), Gaps = 21/306 (6%)
Query: 327 AYHTTGAQLNPKLEKLE-FPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTL-VAVKM 384
A HT Q ++E L FPR + LG GAFG V++ A ++ + VAVK
Sbjct: 1924 AIHTLPTQ--EEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKT 1981
Query: 385 LKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRAC 444
LK ++ +++F +EA L++ F+HPNI+K LGVC + P ++ E M GDL YLR
Sbjct: 1982 LKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKA 2041
Query: 445 STVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN- 503
T + P+ + I+ G +YL F+HRDLA RNCL++
Sbjct: 2042 RMATFYGPL------------LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSV 2089
Query: 504 ----DDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGV 559
+VKI DFGL+ IY DYY+ +PVRWM ES++ +T +SDVW++G+
Sbjct: 2090 KDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGI 2149
Query: 560 CLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
+WEI + QPY ++ +V+ +++ L P N P +++LM QCW P RP F
Sbjct: 2150 LIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFH 2209
Query: 620 VIYQTL 625
I L
Sbjct: 2210 RIQDQL 2215
>UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase MER
precursor; n=30; root|Rep: Proto-oncogene
tyrosine-protein kinase MER precursor - Homo sapiens
(Human)
Length = 999
Score = 193 bits (470), Expect = 1e-47
Identities = 119/314 (37%), Positives = 171/314 (54%), Gaps = 29/314 (9%)
Query: 326 LAYHTTGA--QLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTL--VA 381
L H+ G +L KLE + RN +I + LG+G FG V + G + E+ T VA
Sbjct: 562 LTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVME----GNLKQEDGTSLKVA 617
Query: 382 VKMLK-DEASHDLQLDFEREACLLADFDHPNIVKLLGVC------AIGRPMCLLFEYMGK 434
VK +K D +SH +F EA + DF HPN+++LLGVC I +PM +L +M
Sbjct: 618 VKTMKLDNSSHREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVIL-PFMKY 676
Query: 435 GDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRD 494
GDL+ YL T + + IA GM YLS+R F+HRD
Sbjct: 677 GDLHTYLLYSRLETGPKHIPLQTLLKFMV-------------DIALGMEYLSNRNFLHRD 723
Query: 495 LATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDV 554
LA RNC++ DDM V +ADFGLS KIY DYY+ +PV+W+ +ES+ YT +SDV
Sbjct: 724 LAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDV 783
Query: 555 WAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSD 614
WA+GV +WEI + + PY G+ + E+ +L + L P++ +Y++M CW +P D
Sbjct: 784 WAFGVTMWEIRTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLD 843
Query: 615 RPNFRVIYQTLDNI 628
RP F V+ L+ +
Sbjct: 844 RPTFSVLRLQLEKL 857
>UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca
CG10244-PA; n=3; Endopterygota|Rep: PREDICTED: similar
to Cad96Ca CG10244-PA - Apis mellifera
Length = 657
Score = 192 bits (469), Expect = 2e-47
Identities = 102/300 (34%), Positives = 164/300 (54%), Gaps = 13/300 (4%)
Query: 332 GAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASH 391
GAQ N + +K EFPR+ + LG+G FG+V++ +A + +VAVK LK+ A+
Sbjct: 343 GAQ-NKQEDKWEFPRHRLKVFNILGEGCFGQVWKCEALDIDGKSGAIIVAVKTLKENATE 401
Query: 392 DLQLDFEREACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSF 450
+LD +E ++ + D HPN+V+LLG C PM ++ EY+ G L +LRA
Sbjct: 402 RERLDLAQELRVMKNLDPHPNVVRLLGCCTEREPMFVILEYVSGGKLQSFLRAS------ 455
Query: 451 APVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKI 510
RE QIA GM YL+ + +HRDLA RN LI+++ K+
Sbjct: 456 -----REERNHGGPGLTSRDLTGFVYQIAKGMEYLASKGIIHRDLAARNILIDENRACKV 510
Query: 511 ADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQ 570
ADFG + + Y+ +P+RWM ES+ N ++++SD+W++GV +WEI +
Sbjct: 511 ADFGFARDVAANQIYERKSEGRLPIRWMAPESLYDNIFSVKSDIWSFGVLIWEIVTLGST 570
Query: 571 PYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQL 630
PY G+ EV+R +K+ L P++ R +Y++M CW+ +P+ RP+F + + + L
Sbjct: 571 PYPGLAAAEVMRRIKEGYRLDRPEHCKRELYNIMYYCWDKDPACRPSFGELVSLTEGLLL 630
>UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor) (CD221 antigen); n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Insulin-like growth factor 1 receptor precursor
(Insulin-like growth factor I receptor) (IGF-I receptor)
(CD221 antigen) - Tribolium castaneum
Length = 1277
Score = 192 bits (469), Expect = 2e-47
Identities = 105/286 (36%), Positives = 157/286 (54%), Gaps = 21/286 (7%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E RN+I IR+LG+G+FG V++ GLI ++ A+K + +++S +++F E
Sbjct: 914 EIDRNDIEIIRELGKGSFGTVYE----GLIKSRQYPC-AIKTISEKSSISSKMEFLNEGS 968
Query: 403 LLADFDHPN-IVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
++ F + ++KLLG+ + G ++ E M +GDL YLR C P ++
Sbjct: 969 VMKSFSETHHVIKLLGIVSRGDRPFVIMELMERGDLKSYLRRCR-----GPSQN------ 1017
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL 521
+A +IA GM YLS +KFVHRDLA RNC++ D VKI DFG++ IY
Sbjct: 1018 ----LTTNEIYRMASEIADGMAYLSVKKFVHRDLAARNCMVAADRTVKIGDFGMARDIYE 1073
Query: 522 QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
DYY+ +P+RWM ES+ +T +SDVW+YGV LWE+ + A PY G+ EEV+
Sbjct: 1074 TDYYRKGTAGLLPIRWMAPESLADGVFTTDSDVWSYGVVLWEMATLAELPYQGLGAEEVL 1133
Query: 582 RFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
+F+ L P ++ +M CW P+DRP F I L N
Sbjct: 1134 QFVTSGRTLDMPPQCSDLLHKIMSACWKWRPNDRPTFFSIVDELVN 1179
>UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18;
Euteleostomi|Rep: Transmembrane receptor PTK7-2 - Homo
sapiens (Human)
Length = 1030
Score = 192 bits (468), Expect = 2e-47
Identities = 104/287 (36%), Positives = 156/287 (54%), Gaps = 13/287 (4%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
+K+ FPR+++ I LG+ FG VF AKA GL TLV VK L+ + QLDF R
Sbjct: 747 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQ-QLDFRR 805
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
E + +H N+V+LLG+C P ++ EY+ GDL ++LR + +
Sbjct: 806 ELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR----------ISKSKDE 855
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ Q+A GM +LS+ +FVH+DLA RNCL++ VK++ GLS +
Sbjct: 856 KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV 915
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y +YY +P+RWM E+IL ++ +SDVWA+GV +WE+F+ P+ G +E
Sbjct: 916 YNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDE 974
Query: 580 VVRFLKDENV-LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
V+ L+ L P+ P +Y LM++CW +P DRP+F I L
Sbjct: 975 VLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
>UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precursor;
n=29; Tetrapoda|Rep: Tyrosine-protein kinase-like 7
precursor - Homo sapiens (Human)
Length = 1070
Score = 192 bits (468), Expect = 2e-47
Identities = 104/287 (36%), Positives = 156/287 (54%), Gaps = 13/287 (4%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
+K+ FPR+++ I LG+ FG VF AKA GL TLV VK L+ + QLDF R
Sbjct: 787 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQ-QLDFRR 845
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
E + +H N+V+LLG+C P ++ EY+ GDL ++LR + +
Sbjct: 846 ELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR----------ISKSKDE 895
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ Q+A GM +LS+ +FVH+DLA RNCL++ VK++ GLS +
Sbjct: 896 KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV 955
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y +YY +P+RWM E+IL ++ +SDVWA+GV +WE+F+ P+ G +E
Sbjct: 956 YNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDE 1014
Query: 580 VVRFLKDENV-LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
V+ L+ L P+ P +Y LM++CW +P DRP+F I L
Sbjct: 1015 VLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
>UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|Rep:
Bm-DAF-2 precursor - Brugia malayi (Filarial nematode
worm)
Length = 1456
Score = 191 bits (465), Expect = 6e-47
Identities = 105/287 (36%), Positives = 159/287 (55%), Gaps = 11/287 (3%)
Query: 338 KLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIP--DEEFTLVAVKMLKDEASHDLQL 395
K ++ E R+ I ++G+G FG+V++ F A+K + + A+ +L
Sbjct: 1033 KPDEWELKRSAIHLEDEIGRGTFGKVYRGYGDNCKSYLGVTFGECAIKTVSETANSAERL 1092
Query: 396 DFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEH 455
F EA ++ F+ P IVKL GV + G+P+ ++ E M KG+L +YLR S P +
Sbjct: 1093 HFLIEASVMKQFNTPFIVKLYGVVSDGQPVLVVMEMMKKGNLRDYLR------SRRP--N 1144
Query: 456 REXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGL 515
E A Q+A GM YL KF HRDLA RNC++N+ VKI DFG+
Sbjct: 1145 AEENVNGLPVPGAIDFFRWASQVADGMAYLESLKFCHRDLAARNCMVNEFDTVKIGDFGM 1204
Query: 516 SHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGM 575
+ IY +YYK +PVRWM ES++ K+T++SDVW+YG+ L+E+ + A QPY G+
Sbjct: 1205 ARDIYYHEYYKPAGKRLMPVRWMAPESLMDGKFTMKSDVWSYGITLYEMLTLAQQPYLGL 1264
Query: 576 THEEVVRFL-KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVI 621
+E V ++ + +L P P Y+LMK+CW ++P +RP F I
Sbjct: 1265 ANESVFDYIGVKKKILTRPTGCPDFWYELMKRCWKYDPRERPTFAQI 1311
>UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase receptor - Aedes
aegypti (Yellowfever mosquito)
Length = 2073
Score = 191 bits (465), Expect = 6e-47
Identities = 103/269 (38%), Positives = 153/269 (56%), Gaps = 17/269 (6%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
LG GAFG V++ G+ + E T VA+K L+ A+ + +F +EA L+++F H +I+K
Sbjct: 1818 LGSGAFGEVYEGIVKGVGGEAE-TRVAIKTLRKGATEQEKAEFLQEAHLMSNFKHKHILK 1876
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L+GVC + ++ E M GDL YLR+ + T P +
Sbjct: 1877 LIGVCLDLDSLYIVMELMQGGDLLSYLRS-NRPTPGNP-----------SMLTLLDLISM 1924
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLIND----DMVVKIADFGLSHKIYLQDYYKGDEH 530
+A+G YL + FVHRDLA RNCL++ + VVKI DFGL+ IY DYY+ +
Sbjct: 1925 CVDVATGCRYLEEMHFVHRDLACRNCLVSSMDPRERVVKIGDFGLARDIYKNDYYRKEGE 1984
Query: 531 DAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
+PVRWM ES++ +T +SD+WA+GV LWEI + QPY + EV+ +++D L
Sbjct: 1985 GLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGQQPYPARNNVEVLHYVRDGGRL 2044
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
P + P +Y LM +CW+++P DRP FR
Sbjct: 2045 TRPQDCPEELYQLMLKCWSYSPEDRPTFR 2073
>UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to
ENSANGP00000013218; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000013218 - Nasonia
vitripennis
Length = 972
Score = 190 bits (464), Expect = 7e-47
Identities = 109/286 (38%), Positives = 149/286 (52%), Gaps = 6/286 (2%)
Query: 336 NPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQL 395
+P K EFPR+ + + LG+G FGRV +AKA + + T VAVK LK++AS
Sbjct: 488 SPPDPKWEFPRSRLSIEQVLGEGEFGRVLRAKAQDIAGWQGQTTVAVKTLKEDASASELA 547
Query: 396 DFEREACLLADFDHPNIVKLLGVCAI-GRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
D E LL + HPN+++LLG C G P+ L+ E+ G L YLR + S E
Sbjct: 548 DLLSEYQLLKEAQHPNVIRLLGACTTAGGPIYLIIEFAEFGSLRNYLRRSRHLES----E 603
Query: 455 HREXXXXXXXXXXX-XXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADF 513
R A QI+ GM YL+D K VHRDLA RN L+ V KI+DF
Sbjct: 604 GRPSIDPVVNYTITPRDILSFAWQISKGMAYLADIKLVHRDLAARNVLLGAGKVCKISDF 663
Query: 514 GLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYF 573
GL+ +Y D Y +PV+WM ES+ + YT +SDVW++GV LWE+ + PY
Sbjct: 664 GLTRDVYEDDAYLKRSKGRVPVKWMAPESLADHVYTSKSDVWSFGVLLWELVTLGASPYP 723
Query: 574 GMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
G+ + LK + P N +Y LM CW+ P RP+F+
Sbjct: 724 GVDVHNLYNLLKAGYRMEKPANCSHQLYKLMVSCWHDEPGMRPSFK 769
>UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles sp.|Rep: Tyrosine-protein kinase receptor -
Anopheles sp
Length = 863
Score = 190 bits (464), Expect = 7e-47
Identities = 111/310 (35%), Positives = 168/310 (54%), Gaps = 22/310 (7%)
Query: 324 SNLAYHTTGAQLNPKLEKLEFPRNNIIYIRD---LGQGAFGRVFQAKAPGLIPDEEFTLV 380
+N+ Y ++G+ + ++ L R + I++ LG GAFG V++ G+ + E T V
Sbjct: 424 TNILY-SSGSMTDSEIALLPRIRLDQIFMASSSLLGSGAFGEVYEGVVKGVDGEAE-TRV 481
Query: 381 AVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEY 440
A+K LK A + +F +EA L+++F H +I +LLGVC + ++ E M GDL Y
Sbjct: 482 AIKTLKKGAKLHEKQEFLQEAQLMSNFKHKHITRLLGVCLEADALLIIMELMQGGDLLSY 541
Query: 441 LRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNC 500
L A P+ + + + +ASG YL + FVHRDLA RNC
Sbjct: 542 LPA-------QPLPGQ------AARLTMLDLISMCQDVASGCRYLEEMHFVHRDLACRNC 588
Query: 501 LIND----DMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWA 556
L++ D VVKI DFGL+ IY DYY+ + +PVRWM ES++ +T +SD+WA
Sbjct: 589 LVSSTDPRDRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWA 648
Query: 557 YGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRP 616
+GV LWEI + QPY + EV+ +++ L P P +Y+LMK CW +P +RP
Sbjct: 649 FGVLLWEIMTLGEQPYQAKNNVEVLNHVREGGHLDRPKVCPNEMYELMKYCWKFSPEERP 708
Query: 617 NFRVIYQTLD 626
FR + L+
Sbjct: 709 TFRYCLEVLE 718
>UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12;
Euarchontoglires|Rep: Uncharacterized protein LTK - Homo
sapiens (Human)
Length = 803
Score = 190 bits (464), Expect = 7e-47
Identities = 102/281 (36%), Positives = 145/281 (51%), Gaps = 15/281 (5%)
Query: 348 NIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADF 407
N+ +R LG GAFG V++ GL D VA+K L + S +LDF EA +++ F
Sbjct: 448 NVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 507
Query: 408 DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXX 467
H NIV+ +G+ P +L E M GD+ +LR H
Sbjct: 508 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLR------------HSRPHLGQPSPLV 555
Query: 468 XXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN---DDMVVKIADFGLSHKIYLQDY 524
+A+ IA G YL + F+HRD+A RNCL++ V KI DFG++ IY Y
Sbjct: 556 MRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASY 615
Query: 525 YKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFL 584
Y+ + +PV+WMP E+ L +T ++D W++GV LWEIFS PY G T++EV+ F+
Sbjct: 616 YRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFV 675
Query: 585 KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+ P P VY +M QCW H P RP+F I + L
Sbjct: 676 VGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL 716
>UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor
precursor; n=4; Ascidiacea|Rep: Fibroblast growth factor
receptor precursor - Halocynthia roretzi (Sea squirt)
Length = 763
Score = 190 bits (462), Expect = 1e-46
Identities = 110/296 (37%), Positives = 160/296 (54%), Gaps = 10/296 (3%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLV-AVKMLKDEASHDLQLDFEREA 401
E R +I + L +G FG+VF+A + +V AVKMLK + LD E
Sbjct: 376 ELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEM 435
Query: 402 CLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRAC---STVTSFA-PVEHR 456
+ H NI+ LLGVC P+ L+ EY +G+L +YLR +T+ + P E R
Sbjct: 436 DQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGR 495
Query: 457 ----EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIAD 512
E A Q+A G+ +L+ +K +HRDLA RN L+ +++V+KIAD
Sbjct: 496 NPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIAD 555
Query: 513 FGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY 572
FGL+ I DYY+ +P +WM LE++ N +T +DVW++GV LWEIFS A PY
Sbjct: 556 FGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPY 615
Query: 573 FGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
G+ E+V+FL+ L P + +Y LM+ CW +PS RPNFR + + LD +
Sbjct: 616 PGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRM 671
>UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38;
Euteleostomi|Rep: Tyrosine-protein kinase ABL2 - Homo
sapiens (Human)
Length = 1182
Score = 189 bits (461), Expect = 2e-46
Identities = 106/294 (36%), Positives = 165/294 (56%), Gaps = 25/294 (8%)
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ 394
++P +K E R +I LG G +G V+ G+ T VAVK LK++ +++
Sbjct: 274 VSPIHDKWEMERTDITMKHKLGGGQYGEVYV----GVWKKYSLT-VAVKTLKEDTM-EVE 327
Query: 395 LDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
+F +EA ++ + HPN+V+LLGVC + P ++ EYM G+L +YLR C+ A V
Sbjct: 328 -EFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVV- 385
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
+A QI+S M YL + F+HRDLA RNCL+ ++ VVK+ADFG
Sbjct: 386 ----------------LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
LS ++ D Y P++W ES+ YN ++++SDVWA+GV LWEI ++ + PY G
Sbjct: 430 LS-RLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 488
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ +V L+ + P+ P VY+LM+ CW +P+DRP+F +Q + +
Sbjct: 489 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETM 542
>UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 280
Score = 189 bits (460), Expect = 2e-46
Identities = 100/287 (34%), Positives = 149/287 (51%), Gaps = 9/287 (3%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E PR+ ++ LG+G FG V + + LI +E VA+KMLK +A D RE
Sbjct: 2 EIPRDRVVLKDKLGEGEFGIVMEGEL--LIEEEAPRKVAIKMLKSDADRTDHKDMLRELD 59
Query: 403 LLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
+ H N+V L+G C +G P+ ++ E++ G L E LR +TS
Sbjct: 60 MFKGIGQHENVVSLIGACTLGMPLYIITEFIAGGTLLELLRESRCITS------SYVNAN 113
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL 521
+A A GM ++S +FVHRDLATRN L+ +D+ KI DFGLS IY
Sbjct: 114 LVSKLSGKDLLKLALGAARGMRHISGNRFVHRDLATRNVLVTEDLTAKITDFGLSRDIYS 173
Query: 522 QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
Y + +P++WM ES+L YT +SD+W++GV +WE++SF PY + E++
Sbjct: 174 DGIYLNAKGGKLPLKWMAPESLLDYVYTTQSDIWSFGVLMWEVWSFGAMPYSAVVPNELL 233
Query: 582 RFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L L+ P P +YD+M CWN P RP+F + L+++
Sbjct: 234 SMLMSGFRLSRPPLCPEEIYDVMMSCWNAEPEVRPSFAKLCTVLESL 280
>UniRef50_UPI000065F9C5 Cluster: Epithelial discoidin
domain-containing receptor 1 precursor (EC 2.7.10.1)
(Epithelial discoidin domain receptor 1) (Tyrosine
kinase DDR) (Discoidin receptor tyrosine kinase)
(Tyrosine-protein kinase CAK) (Cell adhesion kinase)
(TRK E) (Protein-tyrosine ki; n=3; Euteleostomi|Rep:
Epithelial discoidin domain-containing receptor 1
precursor (EC 2.7.10.1) (Epithelial discoidin domain
receptor 1) (Tyrosine kinase DDR) (Discoidin receptor
tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell
adhesion kinase) (TRK E) (Protein-tyrosine ki - Takifugu
rubripes
Length = 864
Score = 188 bits (459), Expect = 3e-46
Identities = 130/356 (36%), Positives = 183/356 (51%), Gaps = 44/356 (12%)
Query: 300 HYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGA 359
HY++ ++ S LQ + + LA + GA P E R +I+ LG+G
Sbjct: 515 HYAEADIVS---LQGVSGNNTYAVPALASSSPGADAAPVPE---LSRQCLIFKEKLGEGQ 568
Query: 360 FGRVF--QAKAPGLIPDEEFT---------LVAVKMLKDEASHDLQLDFEREACLLADFD 408
FG V + + P +P EF LVAVK+L+ +AS + + DF +E +L+
Sbjct: 569 FGEVHLCEIENPQDLPILEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLK 628
Query: 409 HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXX 468
PNI++LLGVC + +C++ EYM GDLN+YL + P
Sbjct: 629 DPNIIRLLGVC-VSNDLCMVTEYMECGDLNQYLSHRVLLDKTGP-------SNDAPTVSY 680
Query: 469 XXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN-------DDMV----VKIADFGLSH 517
+A QIASGM +LS FVHRDLATRNCL+ DD +KIADFG+S
Sbjct: 681 PALISMASQIASGMKFLSSLNFVHRDLATRNCLVGGERGDSGDDAGGERHIKIADFGMSR 740
Query: 518 KIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL-QPYFGMT 576
+Y DYY+ +P+RWM E IL K+T SDVWA+GV LWE+ S QPY +T
Sbjct: 741 NLYAGDYYRIQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSNLT 800
Query: 577 HEEVV----RFLKDEN---VLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
E+V+ F +D++ L P P+ +Y+LM CWN + RP+F I+ L
Sbjct: 801 DEQVIDNAGEFFRDQSRQVYLGRPAVCPQGLYELMLSCWNRDCKLRPSFSDIHSFL 856
>UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-oncogene
c-ros-1 protein precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to proto-oncogene c-ros-1 protein
precursor - Apis mellifera
Length = 2105
Score = 188 bits (458), Expect = 4e-46
Identities = 110/292 (37%), Positives = 159/292 (54%), Gaps = 17/292 (5%)
Query: 346 RNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLA 405
R I + LG GAFG VFQ A L T VA+K L+ AS + +F +EA L++
Sbjct: 1804 REQITLAKFLGSGAFGEVFQGNAKDL-ERPGITPVAIKTLRKGASAQEKTEFLQEARLMS 1862
Query: 406 DFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXX 465
F H ++++LLGVC P L+ E M GDL YLRA S P +
Sbjct: 1863 HFRHKHVLRLLGVCLDTDPPLLVLELMEAGDLLSYLRASR---SLQPSDSH--------A 1911
Query: 466 XXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN----DDMVVKIADFGLSHKIYL 521
+ +A G YL + FVHRDLA RNCL++ ++ VVKI DFGL+ IY
Sbjct: 1912 LRLQDLLAMCEDVARGCRYLEELHFVHRDLACRNCLVSAKDRENRVVKIGDFGLARDIYK 1971
Query: 522 QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
DYY+ + +PVRWM ES++ +T +SDVWA+GV +WEI S QPY T+ EV+
Sbjct: 1972 NDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQQPYPARTNIEVL 2031
Query: 582 RFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILE 633
++ L+ P N P ++ LM +CW+ + RP+F+V + + +++ +E
Sbjct: 2032 HHVRAGGRLSKPLNCPLALHQLMLRCWS-DVDTRPSFKVCLENIVSLRSTIE 2082
>UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5;
Eumetazoa|Rep: Tyrosine-protein kinase Abl - Drosophila
melanogaster (Fruit fly)
Length = 1620
Score = 188 bits (458), Expect = 4e-46
Identities = 104/294 (35%), Positives = 160/294 (54%), Gaps = 25/294 (8%)
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ 394
L+P+ ++ E R +I+ LG G +G V++A + VAVK LK++
Sbjct: 357 LSPEPDEWEICRTDIMMKHKLGGGQYGEVYEA-----VWKRYGNTVAVKTLKEDTM--AL 409
Query: 395 LDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
DF EA ++ + HPN+V+L+GVC P ++ E+M G+L ++LR+ T A
Sbjct: 410 KDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDA--- 466
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
+A QIASGM YL R ++HRDLA RNCL+ D+ +VK+ADFG
Sbjct: 467 --------------VALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFG 512
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
L+ ++ D Y P++W E + YNK++ +SDVWA+GV LWEI ++ + PY
Sbjct: 513 LA-RLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPA 571
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ +V L + P P VYDLM+QCW + +DRP F+ I+ L+++
Sbjct: 572 IDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHM 625
>UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000019144 - Anopheles gambiae
str. PEST
Length = 687
Score = 187 bits (455), Expect = 9e-46
Identities = 98/290 (33%), Positives = 157/290 (54%), Gaps = 7/290 (2%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ EFPR+ + LG+GAFG+V++ +A + E ++ AVK LK+ AS + D
Sbjct: 375 DRWEFPRHRLKVFNILGEGAFGQVWRCEATDIDGHEGVSVTAVKTLKENASEAERNDLLS 434
Query: 400 EACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
E +L + H N+V+LLG C P+ ++ EY+ G L +LR S V +H
Sbjct: 435 ELQVLKSLEPHINVVRLLGCCTEKDPIFVILEYVNMGKLQTFLRN-SRVE-----KHYGN 488
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
Q+A GM +L+ R +HRDLA RN LI DD K+ADFG +
Sbjct: 489 THGKSKILTSGDLTSFMYQVARGMDFLTSRGIIHRDLAARNILITDDHTCKVADFGFARD 548
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
I Y+ +P+RWM ES+ N +T++SD+W++G+ +WEI + PY G+
Sbjct: 549 IVTSKVYERKSEGRLPIRWMATESLYDNIFTVKSDIWSFGILMWEIVTLGSTPYPGIAAA 608
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+V+R ++D L P++ R +Y++M CW +P++RP F + + LD +
Sbjct: 609 DVMRKVRDGYRLEKPEHCRRELYNIMFYCWAADPNERPGFPEVVEMLDRL 658
>UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5;
Caenorhabditis|Rep: Tyrosine-protein kinase abl-1 -
Caenorhabditis elegans
Length = 1224
Score = 187 bits (455), Expect = 9e-46
Identities = 112/289 (38%), Positives = 159/289 (55%), Gaps = 25/289 (8%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E R+ II LG G +G V++ G + T +AVK LK++A L +F
Sbjct: 302 DEWELDRSEIIMHNKLGGGQYGDVYE----GYWKRHDCT-IAVKALKEDAM-PLH-EFLA 354
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ D H N+V+LLGVC P ++ E+M G+L EYLR T S P
Sbjct: 355 EAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRR--TDKSLLPP------ 406
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+A QIASGM YL R F+HRDLA RNCL+++ +VKIADFGL+ +
Sbjct: 407 ---------IILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLA-RF 456
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
+D Y P++W E + +N ++ +SDVWA+GV LWEI ++ + PY G+
Sbjct: 457 MKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSN 516
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
V L++ + P P VY LM QCWN +PSDRP FR I+ L+N+
Sbjct: 517 VYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENL 565
>UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO
precursor; n=37; Euteleostomi|Rep: Tyrosine-protein
kinase receptor UFO precursor - Homo sapiens (Human)
Length = 887
Score = 186 bits (453), Expect = 2e-45
Identities = 108/301 (35%), Positives = 162/301 (53%), Gaps = 23/301 (7%)
Query: 334 QLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDL 393
+L KL + R+ + + LG+G FG V + + L D+ VAVK +K
Sbjct: 514 ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQ---LNQDDSILKVAVKTMKIAICTRS 570
Query: 394 QL-DFEREACLLADFDHPNIVKLLGVCAIGRPM------CLLFEYMGKGDLNEYLRACST 446
+L DF EA + +FDHPN+++L+GVC G ++ +M GDL+ +L +
Sbjct: 571 ELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFL--LYS 628
Query: 447 VTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDM 506
PV IASGM YLS ++F+HRDLA RNC++N++M
Sbjct: 629 RLGDQPV-----------YLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENM 677
Query: 507 VVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFS 566
V +ADFGLS KIY DYY+ +PV+W+ +ES+ YT +SDVW++GV +WEI +
Sbjct: 678 SVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIAT 737
Query: 567 FALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
PY G+ + E+ +L+ N L P + +Y LM +CW NP DRP+F + + L+
Sbjct: 738 RGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLE 797
Query: 627 N 627
N
Sbjct: 798 N 798
>UniRef50_Q26614 Cluster: Fibroblast growth factor receptor
precursor; n=4; Eumetazoa|Rep: Fibroblast growth factor
receptor precursor - Strongylocentrotus purpuratus
(Purple sea urchin)
Length = 972
Score = 186 bits (453), Expect = 2e-45
Identities = 103/333 (30%), Positives = 177/333 (53%), Gaps = 9/333 (2%)
Query: 298 KNHYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQLNPKLE-KLEFPRNNIIYIRDLG 356
K+ Y + +V S +++ + ++L S+L T ++ + L+ + EFPR+ + + +G
Sbjct: 590 KHLYRQTSVDSTQSIAPLFGGRNRLTSSL---TVISEYDIPLDPEWEFPRDRLTVGKTIG 646
Query: 357 QGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFD-HPNIVKL 415
+GAFG+V +A G++ E+ + VAVKMLK A D E ++ +PNI+ L
Sbjct: 647 EGAFGKVVIGEAVGIVCQEKTSTVAVKMLKANAMDREFSDLISELAMMKMIGKNPNIINL 706
Query: 416 LGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIA 475
LG C P ++ E+ G+L ++LR+ + + +A
Sbjct: 707 LGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPPEEY----EKSILLTTSQTLTNKDLMSMA 762
Query: 476 RQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPV 535
Q+A GM +L+ +K +HRDLA RN L+ +D +KI DFGL+ I+ D+Y+ +PV
Sbjct: 763 YQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGRLPV 822
Query: 536 RWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDN 595
+WM E++ +T +SDVW++G+ LWEI + PY + E++ +L+ L P N
Sbjct: 823 KWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLRSGKRLEKPQN 882
Query: 596 TPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
T +Y ++ +CW +P RP F + + LD I
Sbjct: 883 TSLEIYHILCECWRTSPGQRPTFCELVEDLDRI 915
>UniRef50_Q9GRH2 Cluster: Tyrosine-protein kinase receptor; n=1;
Sycon raphanus|Rep: Tyrosine-protein kinase receptor -
Sycon raphanus
Length = 616
Score = 186 bits (452), Expect = 2e-45
Identities = 98/291 (33%), Positives = 157/291 (53%), Gaps = 8/291 (2%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E +++ IR++G+GAFG+V++ + D + T VA+K L + + F EA
Sbjct: 211 ELVPDSLTMIREVGEGAFGKVYEGLL-ATVEDGDMT-VAIKTLSVCDTMGQRNAFLAEAS 268
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVT---SFAPVEHREXX 459
++ FD P +++L+G+ + ++ E+M +GDL Y+R C S +E
Sbjct: 269 IMKKFDSPYVMRLMGLVSTENKPLVVMEFMAEGDLRGYVRKCRPQNRQFSINSIETNGSA 328
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
A Q++ GM Y+ ++ FVHRDLA RNC+++ ++ +KI DFG + I
Sbjct: 329 ASVYGIPTAERFMLWALQLSKGMAYVHEKHFVHRDLAARNCMLSSNLTLKIGDFGFTRDI 388
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ A+PVRWM E++ Y ESDVW+YGV LWE+ + QPY G ++EE
Sbjct: 389 YESDYYRKTGKGALPVRWMGPEALRDGMYIPESDVWSYGVVLWEMATLGDQPYKGKSNEE 448
Query: 580 VVRFLKDENVLACP---DNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
V+ + + + P + P+ DLM+ CW P++RP F I LD+
Sbjct: 449 VISLVIAGDHMPLPITLHDFPQPCLDLMETCWQFQPAERPTFEKIVSMLDD 499
>UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora|Rep:
CG14396-PD, isoform D - Drosophila melanogaster (Fruit
fly)
Length = 1237
Score = 186 bits (452), Expect = 2e-45
Identities = 101/288 (35%), Positives = 145/288 (50%), Gaps = 5/288 (1%)
Query: 341 KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFERE 400
K EFPR + LG+G FG+V + A + T VAVKMLK ++ + E
Sbjct: 765 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSE 824
Query: 401 ACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXX 460
LL + HPN++KLLG C L+ EY G L YLR + A V+ +
Sbjct: 825 FQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIEC-AGVDFADGVE 883
Query: 461 XXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIY 520
A QI GM YLS+ K VHRDLA RN L+ D + KI+DFGL+ +Y
Sbjct: 884 PVNVKMVLT----FAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVY 939
Query: 521 LQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEV 580
D Y D +PV+WM ES+ + YT +SDVW++GV WE+ + PY G+ + +
Sbjct: 940 EDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNL 999
Query: 581 VRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
LK + P+N VY +++ CW P+ RP+F+ + + +
Sbjct: 1000 WSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKL 1047
>UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to Alk
CG8250-PA - Apis mellifera
Length = 1436
Score = 185 bits (450), Expect = 4e-45
Identities = 103/286 (36%), Positives = 146/286 (51%), Gaps = 17/286 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
+ PR I IR LGQGAFG VFQ E+ VAVK + + + DF EA
Sbjct: 882 QIPRECITLIRPLGQGAFGEVFQGVYRYRRNQEQ--PVAVKAIPSSSRPQTEADFMMEAL 939
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
+++ F+HPNIV +GV P ++ E + G+L +LR E R
Sbjct: 940 IMSKFNHPNIVHFIGVSFERNPKYIVLELLAGGNLKNFLR-----------EERPRADRP 988
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDD---MVVKIADFGLSHKI 519
+A+G Y+ + +F+HRD+A RNCL+ +VKIADFG++ I
Sbjct: 989 TSLRMQDLIM-CGFDVANGCKYMEEARFIHRDIAARNCLLTSKGPGRIVKIADFGMAKDI 1047
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ +P++WMP ES L +T ++DVWA+GV LWEI SF PY G T+ E
Sbjct: 1048 YRSDYYRKGGKAMLPIKWMPPESFLDGIFTTKTDVWAFGVLLWEIMSFGYIPYTGCTNRE 1107
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+ + L P P +Y LM +CW+ P DRP+F I + +
Sbjct: 1108 AMTMVTLGGRLEKPAGCPDPIYGLMTRCWHPRPEDRPSFATIVERI 1153
>UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep:
Eph receptor B1 - Mus musculus (Mouse)
Length = 943
Score = 185 bits (450), Expect = 4e-45
Identities = 102/278 (36%), Positives = 153/278 (55%), Gaps = 27/278 (9%)
Query: 356 GQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKL 415
G+G FG V++ + +P + VA+K LK S + DF EA ++ FDHPNI++L
Sbjct: 585 GRGEFGEVYKGRLK--LPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 642
Query: 416 LGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIA 475
GV RP+ ++ E+M G L+ +LR F ++ +
Sbjct: 643 EGVVTKSRPVMIITEFMENGALDSFLR--QNDGQFTVIQ----------------LVGML 684
Query: 476 RQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQD-----YYKGDEH 530
R IA+GM YLS+ +VHRDLA RN L+N ++V K++DFGLS YLQD Y
Sbjct: 685 RGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSR--YLQDDTSDPTYTSSLG 742
Query: 531 DAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
IPVRW E+I Y K+T SDVW+YG+ +WE+ SF +PY+ M++++V+ ++ + L
Sbjct: 743 GKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRL 802
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P + P ++ LM CW + + RP F I TLD +
Sbjct: 803 PPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKM 840
>UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 295
Score = 185 bits (450), Expect = 4e-45
Identities = 104/288 (36%), Positives = 151/288 (52%), Gaps = 5/288 (1%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
EFPR+ + LG GAFG V +A A G+ VAVK++K+ S + D E
Sbjct: 3 EFPRDRVKTSVVLGSGAFGVVMKADAQGIKGCVGSLPVAVKIVKENDSDTARRDLMAELD 62
Query: 403 LLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
LL D HPN++ LLG C G P+ ++ E+ GDL YLR C + + +
Sbjct: 63 LLKLIDPHPNVIGLLGCCTRGDPLMVIVEFCQYGDLQSYLRHCRGIED---KYYEQIYMV 119
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL 521
Q A GM +L+ K VHRDLA RN LI++ V K++DFG + IY+
Sbjct: 120 PEKKLTAKDLLSFGIQAARGMAHLASMKVVHRDLAARNILIDEKSVCKVSDFGFARDIYV 179
Query: 522 QDYY-KGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEV 580
+D+Y + + P++WM +ES+L T +SDVW+YGV LWEI + PY GM +EV
Sbjct: 180 EDHYTRKTQGGRFPIKWMAIESLLDGVSTTKSDVWSYGVLLWEIVTLGASPYPGMNSQEV 239
Query: 581 VRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ FL+D + P + +Y +M CW + RP F I + L+ +
Sbjct: 240 INFLQDGYRMDKPKHCLDELYAVMLDCWQLSAQRRPTFVEISRLLNKM 287
>UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 304
Score = 184 bits (448), Expect = 6e-45
Identities = 110/297 (37%), Positives = 152/297 (51%), Gaps = 15/297 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLV------AVKMLKDEASHDLQLD 396
E PR+++ R LG GAFG V +AK P+EE V AVKMLK+ + D
Sbjct: 1 EIPRDDLTIERQLGSGAFGVVKKAKTEE--PEEEKGKVLEIVPCAVKMLKENPTESELRD 58
Query: 397 FEREACLLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEH 455
E ++A DHPNIV LLG C + P+ L+ + G +Y++ +V + E+
Sbjct: 59 LCNEIAIMALVGDHPNIVSLLGACTVNGPLWLVVKLAENGCFLDYIKEHRSVVEYENTEN 118
Query: 456 REXXXXXXXXXXXXXXXX------IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVK 509
+ A +IA GM +L +K VHRDLA RN L+N D V
Sbjct: 119 KIHSYENVTEKTQGAPMTEKEKFKFAYEIAKGMRHLEKKKCVHRDLAARNILLNVDNVAM 178
Query: 510 IADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL 569
++DFGLS +Y Y +PVRWM +ES+ YT +SDVW+YGV LWE+ S L
Sbjct: 179 VSDFGLSRDVYESGAYDNTTGGVLPVRWMAIESLEDYTYTTKSDVWSYGVLLWEMESGGL 238
Query: 570 QPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
PY GM+ E++ LK L P + +Y LM +CWN P +RP F +I L+
Sbjct: 239 MPYAGMSGVEILERLKQGYRLEKPSCCSQELYALMYECWNPEPKNRPAFSIIVSRLE 295
>UniRef50_UPI0000519EF1 Cluster: PREDICTED: similar to CG31640-PA;
n=2; Apis mellifera|Rep: PREDICTED: similar to
CG31640-PA - Apis mellifera
Length = 882
Score = 184 bits (447), Expect = 9e-45
Identities = 109/305 (35%), Positives = 161/305 (52%), Gaps = 27/305 (8%)
Query: 342 LEFPRNNIIYIRDLGQGAFGRVFQAKA---PGLIPDEEFT-----LVAVKMLKDEASHDL 393
L+FPR + + +LG G FG V + PG DE F LV VK L+ +S L
Sbjct: 578 LDFPREKLNIVENLGCGYFGDVHICEVDRFPGY--DEVFRNTASDLVIVKSLRPGSSDAL 635
Query: 394 QLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPV 453
+++F+ EA LA N+ +LLG PMC++ E GDLN+YL+ TS
Sbjct: 636 RIEFQEEAKKLARLADRNVARLLGASLGDDPMCIVLENGEYGDLNQYLQRHIAETS---- 691
Query: 454 EHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADF 513
+A QIASGM +L + VHRDLATRNCL++ VK+ D
Sbjct: 692 -----TVHTAKTLSFGTLIYMATQIASGMKHLEEMDLVHRDLATRNCLVSRGYTVKVCDL 746
Query: 514 GLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL-QPY 572
G Y DY++ + +P+RWM E++L ++T +SDVW++ V LWEI +FA QP+
Sbjct: 747 GSGRNAYAADYFRVEGRPPLPIRWMAWEAMLMGRHTSKSDVWSFAVTLWEILTFAREQPF 806
Query: 573 FGMTHEEVVR----FLKDEN---VLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+ +V F ++++ +L P N P+ +Y+LM++CW+ N DRP+FR I+ L
Sbjct: 807 EELPDHRIVENATYFYQEDDRRIILPLPKNCPKDIYELMRECWHRNDVDRPSFREIHMFL 866
Query: 626 DNIQL 630
L
Sbjct: 867 QRKNL 871
>UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:
Protein sevenless - Drosophila melanogaster (Fruit fly)
Length = 2554
Score = 184 bits (447), Expect = 9e-45
Identities = 108/290 (37%), Positives = 150/290 (51%), Gaps = 18/290 (6%)
Query: 352 IRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPN 411
+R LG GAFG V++ + EE VA+K L+ AS +L +EA L+++F H N
Sbjct: 2212 LRFLGSGAFGEVYEGQLK-TEDSEEPQRVAIKSLRKGASEFAEL--LQEAQLMSNFKHEN 2268
Query: 412 IVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXX 471
IV L+G+C + L+ E+M GDL YLRA ++ P
Sbjct: 2269 IVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQP--------TAGLSLSEL 2320
Query: 472 XXIARQIASGMLYLSDRKFVHRDLATRNCLINDDM-------VVKIADFGLSHKIYLQDY 524
+ +A+G YL D FVHRDLA RNCL+ + VKI DFGL+ IY DY
Sbjct: 2321 LAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDY 2380
Query: 525 YKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFL 584
Y+ + +PVRWM ES++ +T +SDVWA+GV WEI + QPY + EV+ +
Sbjct: 2381 YRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHV 2440
Query: 585 KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILER 634
K+ L P +Y L+ CW +P +RP+FR Y TL I L R
Sbjct: 2441 KEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRR 2490
>UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 4 SCAF14752, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 810
Score = 183 bits (446), Expect = 1e-44
Identities = 103/293 (35%), Positives = 158/293 (53%), Gaps = 26/293 (8%)
Query: 335 LNPKLEKLEFPRNN--IIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHD 392
LNP ++ ++ N+ ++ LG+G FG VF+ G + ++ T VAVK K++ +
Sbjct: 536 LNPVVKDKKWILNHEDVVLGELLGKGNFGEVFK----GTLQRDK-TPVAVKTCKEDLPSE 590
Query: 393 LQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAP 452
L++ F EA +L +DHPNIVKL+GVC +P+ ++ E + GD YLR
Sbjct: 591 LKIRFLSEARILKQYDHPNIVKLIGVCTQRQPIYIVMELVPGGDFLSYLRK--------- 641
Query: 453 VEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIAD 512
A A+GM YL + +HRDLA RNCL+ D+ +KI+D
Sbjct: 642 ---------KKDELKTKQLLRFAVDAAAGMAYLESKNCIHRDLAARNCLVGDNNALKISD 692
Query: 513 FGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY 572
FG+S + Y IP++W E++ Y +Y+ ESDVW+YG+ LWE FS + PY
Sbjct: 693 FGMSRQED-DGIYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSYGILLWETFSLGMCPY 751
Query: 573 FGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
GMT+++ ++ +ACP P VY +M++CW +NP DRP F + + L
Sbjct: 752 PGMTNQQAREQVEKGYRMACPQRCPDDVYKVMQRCWQYNPEDRPKFSELQRDL 804
>UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF15039, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 978
Score = 183 bits (446), Expect = 1e-44
Identities = 107/276 (38%), Positives = 146/276 (52%), Gaps = 10/276 (3%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADF-DHPNIV 413
+G+G FG+V +A D A+KMLK+ AS + DF E +L HPNI+
Sbjct: 685 IGEGNFGQVIKAMVK---KDGNKMSAAIKMLKEFASENDHRDFAGELEVLCKLGQHPNII 741
Query: 414 KLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXX 473
L+G C + + EY G+L ++LR S V P +E
Sbjct: 742 NLIGACENRGYLYIAIEYAPYGNLLDFLRK-SRVLETDPAFAKEHGTASTLTSQQLLQFA 800
Query: 474 IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAI 533
+ +A+GM YLSD++F+HRDLA RN L+ D++V KIADFGLS ++ Y +
Sbjct: 801 V--DVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRG---EEVYVKKTMGRL 855
Query: 534 PVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACP 593
PVRWM +ES+ Y+ YT +SDVW++GV LWEI S PY GMT E+ L + P
Sbjct: 856 PVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGFRMEKP 915
Query: 594 DNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQ 629
N VY+LMKQCW P +RP F I L +Q
Sbjct: 916 KNCDDEVYELMKQCWRDRPYERPPFSQISVQLSRMQ 951
>UniRef50_Q59DZ7 Cluster: CG33531-PA; n=6; Sophophora|Rep: CG33531-PA
- Drosophila melanogaster (Fruit fly)
Length = 1064
Score = 183 bits (446), Expect = 1e-44
Identities = 111/310 (35%), Positives = 160/310 (51%), Gaps = 31/310 (10%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEF------TLVAVKMLKDEASHDLQLD 396
EFPR +++ + LG G FG + + L EF TLVAV L+ A+ L+ +
Sbjct: 753 EFPRQSLVIVEKLGSGVFGELHLCETNVLNDLTEFDSHCSATLVAVATLRPGANDHLRKE 812
Query: 397 FEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMG-KGDLNEYLRACSTVTSFAPVEH 455
F +A LA PN+ +L+G C P+C++ +Y GDLN++L+ TS
Sbjct: 813 FRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETS------ 866
Query: 456 REXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG- 514
IA QIASGM +L FVHRDLATR+C+I ++ VK+ G
Sbjct: 867 ---GLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGT 923
Query: 515 -LSHKIYLQDY-----YKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFA 568
++ Y DY + G + +P+RWM ES+L K+T +SDVW++ V LWEI +FA
Sbjct: 924 VINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFA 983
Query: 569 L-QPYFGMTHEEVV-------RFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRV 620
QPY ++ + V+ R K +L P N PR +YDLM +CW + S RP+FR
Sbjct: 984 REQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFRE 1043
Query: 621 IYQTLDNIQL 630
I+ L L
Sbjct: 1044 IHLYLQRKNL 1053
>UniRef50_UPI00015B4B9F Cluster: PREDICTED: similar to
prenylcysteine oxidase 1; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to prenylcysteine oxidase 1 - Nasonia
vitripennis
Length = 807
Score = 183 bits (445), Expect = 1e-44
Identities = 102/249 (40%), Positives = 143/249 (57%), Gaps = 14/249 (5%)
Query: 344 FPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFT------LVAVKMLKDEASHDLQLDF 397
FPR+ + + L +GAFG V+ A+A G IP+ T LVAVK L EA+ +LDF
Sbjct: 41 FPRHRLRMLSKLAEGAFGSVYIAEAEG-IPEYGTTTTLGKRLVAVKFLLPEANEKEKLDF 99
Query: 398 EREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHRE 457
+R+ +LA + NI ++LG C P C++ EY+ GDL ++L+ T E
Sbjct: 100 QRDVRILAALEDRNIARVLGACCREEPFCVVMEYLEHGDLCQFLKTHVTA------EDAH 153
Query: 458 XXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSH 517
+A QIASGM YL + FVHRDLATRNCL+ +KI+DFG +
Sbjct: 154 SMPIGVKTLSFNCLIYMAAQIASGMRYLENLNFVHRDLATRNCLVGKAYHIKISDFGTDN 213
Query: 518 KIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQ-PYFGMT 576
++Y DYYK D +PVRWM ES++ KYT +SDVW++ V LWEI + + PY ++
Sbjct: 214 ELYACDYYKVDGGIPLPVRWMAWESLVLGKYTTKSDVWSFAVMLWEILNLGRRVPYEHLS 273
Query: 577 HEEVVRFLK 585
+EVVR L+
Sbjct: 274 DQEVVRCLR 282
Score = 34.7 bits (76), Expect = 7.7
Identities = 12/29 (41%), Positives = 19/29 (65%)
Query: 593 PDNTPRCVYDLMKQCWNHNPSDRPNFRVI 621
P + + +YDLM +CW + ++RP F VI
Sbjct: 321 PSASSKDIYDLMLECWRRDEAERPTFPVI 349
>UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep:
CG1511-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 1096
Score = 183 bits (445), Expect = 1e-44
Identities = 105/289 (36%), Positives = 150/289 (51%), Gaps = 24/289 (8%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKA---PGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
E N I +G G FG V + + P + D + VA+K LK +S + DF
Sbjct: 735 EIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDID---VAIKTLKPGSSEKARCDFLT 791
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ FDHPN++ L GV P+ ++ EYM G L+ +LR F ++
Sbjct: 792 EASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDG--KFQTLQ----- 844
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ R IASGM YLSD +VHRDLA RN L+N ++ KIADFGLS +I
Sbjct: 845 -----------LIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREI 893
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
IPVRW E+I + K+T SDVW+YGV LWE+ S+ +PY+ ++++
Sbjct: 894 ENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQD 953
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
V++ ++ L P + P +Y LM CW + RP F I TLDN+
Sbjct: 954 VIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNL 1002
>UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 183 bits (445), Expect = 1e-44
Identities = 108/296 (36%), Positives = 157/296 (53%), Gaps = 7/296 (2%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLI--PDEEFTLVAVKMLKDEASHDLQ 394
P+ ++ E ++I + +G GAFG+V +A GL P+ + T+VAVK L A+ + +
Sbjct: 6 PEPDEWEVDYSSIAFGEVVGSGAFGKVTKATIVGLPGGPENKETVVAVKKLNAMATMEDR 65
Query: 395 LDFEREACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPV 453
+F E ++ H NIV +LG +CL+ EY GDL YLRA S
Sbjct: 66 RNFLSEIEMMKQLGKHLNIVSILGCVTHAGQLCLITEYCPYGDLRNYLRAIRDKVS---T 122
Query: 454 EHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADF 513
ARQIA GM YLS + FVHRDLA RN LI +D +VKI+DF
Sbjct: 123 RDSLAGRAPGRELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDF 182
Query: 514 GLSHKIY-LQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY 572
GL+ +Y +Y+K +P++WM E+I N +T +SDVWA+GV LWEI + PY
Sbjct: 183 GLTRDVYESSEYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPY 242
Query: 573 FGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
G + +E + LK+ + PD +Y +M+ CW +P DRP F + L+ +
Sbjct: 243 PGQSGKEFYKKLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKLRNQLEQL 298
>UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 343
Score = 182 bits (444), Expect = 2e-44
Identities = 108/311 (34%), Positives = 161/311 (51%), Gaps = 11/311 (3%)
Query: 318 DLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEF 377
D + + SN T A+ + + LE P + + R++G+GAFG VF A A L
Sbjct: 9 DWEIIVSNAHASFTEARAKGEADLLEVPHSCLRIGREIGKGAFGHVFIANASKLPHCNGP 68
Query: 378 TLVAVKMLKDEASHDLQLD-FEREACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKG 435
LVAVK LK + + F E ++ HPNIV LLG C + P+ ++ EY+G G
Sbjct: 69 KLVAVKQLKKCPKRKPEFEEFLDEIAMMKQVGKHPNIVALLGCCTLKEPLTMIMEYIGCG 128
Query: 436 DLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDL 495
DL T P + ARQIA GM +L ++ HRDL
Sbjct: 129 DL-----VTMYTTLSGPNDSSREHSALEYLLDHKELHDFARQIACGMKHLEEKNITHRDL 183
Query: 496 ATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVW 555
A RN LI++ +KI+DFGLS Y + +P+RW+ +E++ + Y+ +SDVW
Sbjct: 184 AARNILIDEKKTLKISDFGLSRT----GIYVNTRNKKVPLRWLSIEAMRDHLYSSKSDVW 239
Query: 556 AYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDR 615
A+G+ LWEI + PY +++ E++ FL + N L P+N +Y+LM CW P DR
Sbjct: 240 AFGIVLWEIGTLGGYPYPTVSNHELLSFLHNGNRLDRPENCSAELYELMLHCWKAEPDDR 299
Query: 616 PNFRVIYQTLD 626
P+F IY++L+
Sbjct: 300 PSFADIYKSLE 310
>UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein
kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor
tyrosine kinase MerTK).; n=1; Xenopus tropicalis|Rep:
Proto-oncogene tyrosine-protein kinase MER precursor (EC
2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK). -
Xenopus tropicalis
Length = 763
Score = 182 bits (443), Expect = 3e-44
Identities = 112/301 (37%), Positives = 162/301 (53%), Gaps = 23/301 (7%)
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLK-DEASHDL 393
L KLE + RN + + LG+G FG V + + D VAVK +K D S
Sbjct: 457 LQQKLEDVMVERNLLNLGKVLGEGEFGSVMEGELQ--YSDGTNHKVAVKTMKMDNFSQRE 514
Query: 394 QLDFEREACLLADFDHPNIVKLLGVCA------IGRPMCLLFEYMGKGDLNEYLRACSTV 447
+F EA + DF+HPN+++LLGVC I +PM +L +M GDL+ +L +
Sbjct: 515 IEEFLSEAACMKDFNHPNVIRLLGVCLEVGPRRIPKPMVIL-PFMKYGDLHSFLLSSRIG 573
Query: 448 TSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMV 507
+ V R IA+GM YLS R F+HRDLA RNC++ DDM
Sbjct: 574 SGPQHVPLRTLVKFMI-------------DIATGMEYLSSRNFLHRDLAARNCMLRDDMT 620
Query: 508 VKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSF 567
V +ADFGLS KIY DYY+ +PV+W+ +ES+ YT++SDVWA+GV +WEI +
Sbjct: 621 VCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAVESLADRIYTVKSDVWAFGVTMWEISTR 680
Query: 568 ALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
+ PY G+ + E+ +L + L P +Y +M QCW +P+ RP+F + + L+
Sbjct: 681 GMTPYPGVQNHEIYDYLLVGHRLKQPPECLDDLYTVMYQCWLSDPTCRPSFTALRENLEK 740
Query: 628 I 628
I
Sbjct: 741 I 741
>UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41;
Euteleostomi|Rep: Angiopoietin-1 receptor precursor -
Homo sapiens (Human)
Length = 1124
Score = 182 bits (443), Expect = 3e-44
Identities = 116/295 (39%), Positives = 153/295 (51%), Gaps = 17/295 (5%)
Query: 347 NNIIYIRDLGQGAFGRVFQA--KAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLL 404
N+I + +G+G FG+V +A K GL D A+K +K+ AS D DF E +L
Sbjct: 822 NDIKFQDVIGEGNFGQVLKARIKKDGLRMD-----AAIKRMKEYASKDDHRDFAGELEVL 876
Query: 405 ADFDH-PNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXX 463
H PNI+ LLG C + L EY G+L ++LR S V P
Sbjct: 877 CKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRK-SRVLETDPAF--AIANSTA 933
Query: 464 XXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQD 523
A +A GM YLS ++F+HRDLA RN L+ ++ V KIADFGLS Q+
Sbjct: 934 STLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG---QE 990
Query: 524 YYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRF 583
Y +PVRWM +ES+ Y+ YT SDVW+YGV LWEI S PY GMT E+
Sbjct: 991 VYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK 1050
Query: 584 LKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILERGRTH 638
L L P N VYDLM+QCW P +RP+F Q L ++ +LE +T+
Sbjct: 1051 LPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFA---QILVSLNRMLEERKTY 1102
>UniRef50_UPI0000D576E5 Cluster: PREDICTED: similar to CG33531-PA;
n=6; Endopterygota|Rep: PREDICTED: similar to CG33531-PA
- Tribolium castaneum
Length = 935
Score = 182 bits (442), Expect = 3e-44
Identities = 95/251 (37%), Positives = 140/251 (55%), Gaps = 13/251 (5%)
Query: 379 LVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLN 438
LVA+K L + A+ + DF R+ +LA + PNI ++LG+C+ P+C++ EY+ GDL
Sbjct: 678 LVAIKFLGENAAEKEKKDFYRDVRILAALEDPNIARVLGICSQEEPICVVMEYLDHGDLC 737
Query: 439 EYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATR 498
++L+ + A + + + QIASGM YL FVHRDLATR
Sbjct: 738 QFLKTHVAADNNASLPY------GVKSLSFNCLLYMGAQIASGMRYLESLNFVHRDLATR 791
Query: 499 NCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYG 558
NCLI +KI DFG +++Y+ DYYK D + +P+RWM ES+ +YT +SDVWA+
Sbjct: 792 NCLIGKGYQIKICDFGTYNELYINDYYKVDGNTPLPIRWMAWESVYQTRYTTKSDVWAFA 851
Query: 559 VCLWEIFSFALQ-PYFGMTHEEVVRFL-----KDENVLACPDNT-PRCVYDLMKQCWNHN 611
V LWEI + + PY + EV+ L D + P T + +YDLM +CW
Sbjct: 852 VTLWEILTLCRRPPYDSLPDPEVMENLAHMHCDDGQYMYLPRPTASKDIYDLMLECWRRK 911
Query: 612 PSDRPNFRVIY 622
+RP+FR I+
Sbjct: 912 DVERPSFREIH 922
>UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10;
Endopterygota|Rep: Tyrosine-protein kinase Btk29A -
Drosophila melanogaster (Fruit fly)
Length = 786
Score = 182 bits (442), Expect = 3e-44
Identities = 104/287 (36%), Positives = 152/287 (52%), Gaps = 27/287 (9%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEA-SHDLQLDFE 398
+K E ++ + +LG G FG V + K G I AVKM+K+ S D DF
Sbjct: 517 DKWEIHPMELMLMEELGSGQFGVVRRGKWRGSID------TAVKMMKEGTMSED---DFI 567
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
EA ++ HPN+V+L GVC+ RP+ ++ EYM G L YLR H +
Sbjct: 568 EEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR-----------RHEKT 616
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
+ Q++ GM YL ++HRDLA RNCL+ + VVK+ADFGL+
Sbjct: 617 LIGNMGLLLD-----MCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARY 671
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
+ L D Y P++W P E + Y +++ +SDVWAYGV +WEIF+ PY + +
Sbjct: 672 V-LDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNT 730
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
EVV ++ +L P + + +YD+MK CW+H P +RP FRV+ L
Sbjct: 731 EVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
>UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephrin
receptor - Gallus gallus (Chicken)
Length = 969
Score = 181 bits (441), Expect = 5e-44
Identities = 103/276 (37%), Positives = 156/276 (56%), Gaps = 25/276 (9%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G+G FG V++ +P +E +VA+K LK S +F REA ++ F+HPNIV
Sbjct: 622 IGEGEFGEVYRGSLR--LPGKERIVVAIKTLKSTYSDSQWWNFLREATIMGQFNHPNIVH 679
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV RPM ++ EYM G L+ +LR F+PV+ +
Sbjct: 680 LEGVVTKRRPMMIITEYMENGALDTFLR--ENEEKFSPVQ----------------LVNM 721
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGD---EHD 531
+ IASGM YLS+ +VHRDLA RN L+ + K++DFGLS L++ +G +
Sbjct: 722 LQGIASGMTYLSEHNYVHRDLAARNILVTRSLQCKVSDFGLSR--ILENDAEGTYETKGG 779
Query: 532 AIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLA 591
IP+RW E+I + +T SDVW++G+ +WE+ SF +PY MT++EV++ L+D L
Sbjct: 780 KIPIRWTAPEAIAHRIFTSASDVWSFGIVMWEVLSFGDKPYGNMTNQEVMKSLEDGYRLP 839
Query: 592 CPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
P + P +Y+LMK CW+H+ RP+F+ I L +
Sbjct: 840 PPVDCPSILYELMKSCWSHDRMRRPHFQEIRAQLQH 875
>UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;
Obtectomera|Rep: Fibroblast growth factor receptor -
Bombyx mori (Silk moth)
Length = 856
Score = 180 bits (439), Expect = 8e-44
Identities = 96/287 (33%), Positives = 154/287 (53%), Gaps = 4/287 (1%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E PR ++ + LG+G FG+V +A+ G++ ++VAVKMLK+ + + E
Sbjct: 534 EVPRESLSLGKVLGEGEFGKVVKAECIGILKPGLQSVVAVKMLKEGHTDAEMMALVSEME 593
Query: 403 LLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
++ H NI+ LLG C P+ ++ EY G+L E+LR + E
Sbjct: 594 MMKMIGKHVNIINLLGCCTQDGPLYVIVEYAPNGNLREFLRNHRPGNRY---ESPNEDLK 650
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL 521
+ Q+A GM YL+ R+ +HRD A RN L++DD V+KIADFGL+ ++
Sbjct: 651 EKKTLTQKDLVSFSYQVARGMEYLASRRCIHRDSAARNVLVSDDCVLKIADFGLAKDVHS 710
Query: 522 QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
DYY+ +PVRWM ES+ + +T ++DVW++GV LWEI + PY + + +
Sbjct: 711 NDYYRKKTEGRLPVRWMAPESLYHKVFTTQTDVWSFGVLLWEIMTLGGTPYPTVPGQYMY 770
Query: 582 RFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ L + + P +Y LM++CW+ +P DRP+F + + LD I
Sbjct: 771 QHLSAGHRMEKPPCCSLEIYMLMRECWSFSPGDRPSFTELVEDLDKI 817
>UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homolog
2 precursor; n=4; Coelomata|Rep: Fibroblast growth
factor receptor homolog 2 precursor - Drosophila
melanogaster (Fruit fly)
Length = 1052
Score = 180 bits (439), Expect = 8e-44
Identities = 105/294 (35%), Positives = 156/294 (53%), Gaps = 8/294 (2%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGL--IPDEEFTLVAVKMLKDEASHDLQLDFERE 400
E PR + LG+GAFGRV A+A GL P T+VAVKM+K+E + RE
Sbjct: 706 EIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVRE 765
Query: 401 ACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLR----ACSTVTSFAPVEH 455
++ H NI+ LLG C+ G P+ ++ EY G+L ++L+ S +
Sbjct: 766 MEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYL 825
Query: 456 REXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGL 515
+ A QIA GM YL+ R+ +HRDLA RN L++D V+KIADFGL
Sbjct: 826 DDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGL 885
Query: 516 SHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY-FG 574
+ I +YY+ + + +P++WM ES+ KY +SDVW+YGV LWEI ++ QPY
Sbjct: 886 ARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHI 945
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
++ EE+ +L + P +Y +M+QCW+ RP F + ++ D I
Sbjct: 946 LSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGI 999
>UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG10023-PA, isoform A - Tribolium castaneum
Length = 1106
Score = 180 bits (438), Expect = 1e-43
Identities = 108/304 (35%), Positives = 163/304 (53%), Gaps = 31/304 (10%)
Query: 332 GAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRV----FQAKAPGLIPDEEFTLVAVKMLKD 387
G P + E R+ I LG+G FG V ++AK LIP VAVK K
Sbjct: 411 GDYSTPATKSYELQRDQIQLGEILGEGQFGDVHKGTYKAKDGSLIP------VAVKTCKR 464
Query: 388 EASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTV 447
EA + F EA ++ FDH +I+KL+GVC+ P+ ++ E G+L YL+
Sbjct: 465 EADLNTTEKFLEEAYIMQKFDHQHIIKLIGVCSES-PVWIVMELAKLGELRAYLQNNKDD 523
Query: 448 TSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMV 507
A + A Q+++ + YL +KFVHRD+A RN L++
Sbjct: 524 LDLATL------------------LLYAFQLSTALSYLESKKFVHRDIAARNVLVSSHTS 565
Query: 508 VKIADFGLSHKIYL-QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFS 566
VK+ DFGLS + Q YYK + +P++WM ESI + ++T+ SDVW +GVC+WEI
Sbjct: 566 VKLGDFGLSRSMNDDQSYYKASK-GKLPIKWMSPESINFRRFTIASDVWMFGVCMWEILM 624
Query: 567 FALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
+ ++P+ G+ + EV+ +++ LA P N P +Y LM QCW++ PS RP+F+ I + L+
Sbjct: 625 YGIKPFQGVKNNEVLTKIENGERLALPPNCPPRLYSLMSQCWSYEPSKRPSFKEIKEILN 684
Query: 627 NIQL 630
I L
Sbjct: 685 EILL 688
>UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 709
Score = 180 bits (438), Expect = 1e-43
Identities = 110/307 (35%), Positives = 160/307 (52%), Gaps = 24/307 (7%)
Query: 321 KLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRD-LGQGAFGRVFQAKAPGLIPDEEFTL 379
K+PSN H +G L P+ + I D +GQG FG V++A L
Sbjct: 365 KIPSNYLRHLSGKMLIPE---------QCLQIMDCIGQGEFGIVYRAYLREWAKYPSPHL 415
Query: 380 VAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVC-AIGRPMCLLFEYMGKGDLN 438
VAVK +K E S E+ + DFDHPNI+ L+GVC AI ++ +M G L
Sbjct: 416 VAVKTIKGETSDSQISQMLEESVKMKDFDHPNILSLIGVCIAIESSPYIVMPFMANGSLL 475
Query: 439 EYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATR 498
YL+ + A ++ I QIA GM YL+ +KFVHRDLA R
Sbjct: 476 SYLKQQRHNLTIANGAEQDLITETQRVLLS-----ICLQIAKGMEYLASQKFVHRDLAAR 530
Query: 499 NCLINDDMVVKIADFGLSHKIYLQDYYKGDEHD----AIPVRWMPLESILYNKYTLESDV 554
NC+I+ + V+K+ADFGLS +Y ++YY+ + + +P+RWM ES ++ ++DV
Sbjct: 531 NCMIDLNNVIKVADFGLSEDMYAKNYYRQSDVEECKVKLPIRWMAPESFHDGVFSEKTDV 590
Query: 555 WAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRC---VYDLMKQCWNHN 611
W+YGV WE+F+ PY G+T ++++L + L P N C +YDLM++CW
Sbjct: 591 WSYGVTCWEVFTLGKIPYPGVTPFTLIKYLDEGGRLEKPSNA-ACSDQIYDLMRKCWCQE 649
Query: 612 PSDRPNF 618
DRP F
Sbjct: 650 SEDRPPF 656
>UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homolog
1 precursor; n=3; Sophophora|Rep: Fibroblast growth
factor receptor homolog 1 precursor - Drosophila
melanogaster (Fruit fly)
Length = 729
Score = 180 bits (438), Expect = 1e-43
Identities = 105/292 (35%), Positives = 155/292 (53%), Gaps = 16/292 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E PR++++ LG+GAFGRV A+ I VAVKM+K+ + D RE
Sbjct: 410 ELPRSHLVLGATLGEGAFGRVVMAEVNNAI-------VAVKMVKEGHTDDDIASLVREME 462
Query: 403 LLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX-- 459
++ H NI+ LLG C+ P+ ++ EY G+L ++L F + R+
Sbjct: 463 VMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRP---FGRDQDRDSSQP 519
Query: 460 --XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSH 517
A QIA GM YL+ R+ +HRDLA RN L++DD V+KIADFGL+
Sbjct: 520 PPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLAR 579
Query: 518 KIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY-FGMT 576
I DYY+ + + +P++WM ES+ Y +SDVW+YG+ LWEI ++ QPY M+
Sbjct: 580 DIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMS 639
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
EE+ +L + P +Y LM+QCW+ N DRP F I + +D +
Sbjct: 640 AEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691
>UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
Cek8 - Strongylocentrotus purpuratus
Length = 775
Score = 180 bits (437), Expect = 1e-43
Identities = 102/286 (35%), Positives = 147/286 (51%), Gaps = 21/286 (7%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E I + +G G FG V L+PD+ VAVK LK A+ + DF EA
Sbjct: 411 EIDATQIRILEVIGGGEFGDVCSGLM--LMPDKTTIKVAVKTLKTGATDKDRSDFLSEAS 468
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
++ FDHPN++KLLGV RP ++ E+M G L++YLR
Sbjct: 469 IMGQFDHPNVIKLLGVVTKTRPAMIVTEFMENGSLDKYLRE------------------N 510
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ 522
+ R + GM +LS+ FVHRDLA RN L+N+ +V K+ADFGLS + L
Sbjct: 511 DGRFTVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKELD 570
Query: 523 DYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVR 582
Y+ IP+RW E+I Y K+T SDVW+ GV +WEI S+ +PY+ +++V++
Sbjct: 571 GAYE-TRGGKIPIRWTAPEAIGYKKFTSASDVWSLGVVMWEIMSYGERPYWNWPNQDVIK 629
Query: 583 FLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
++ L P P ++ LM CW + + RP F I TLD +
Sbjct: 630 AVEKGYRLPPPMECPEAIHQLMLDCWQRDRNHRPTFTTIVSTLDRL 675
>UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1048
Score = 180 bits (437), Expect = 1e-43
Identities = 118/369 (31%), Positives = 185/369 (50%), Gaps = 35/369 (9%)
Query: 272 VLLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSRR-------NLQNMDIDLDKLPS 324
+++ IGG V+AI I C K+H +K + + +L+N I +P
Sbjct: 559 LIIAVIGGCSIVIAIVLIVFCCRR--KSHQNKSKLDMEKLPMFVMGHLKNGSIGY--MPG 614
Query: 325 NLAYHTTGAQLNPKLEKLEFPRN---NIIYIRD-LGQGAFGRVFQAKAPGLIPDEEFTLV 380
+ Y +P L+F + + I I + +G G FG V + +E V
Sbjct: 615 HKTYIDPTTYEDPARAVLDFTKEIDASYIGIEEVIGGGEFGEVCLGRMRLPNSKKEHD-V 673
Query: 381 AVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEY 440
A+K LK S +LDF EA ++ FDHPN+++L GV +P ++ EYM G L+ +
Sbjct: 674 AIKTLKAGYSTQQKLDFLGEASIMGQFDHPNVIRLEGVVTKSQPHMIITEYMENGSLDTF 733
Query: 441 LRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNC 500
LR F ++ I R IA+GM YLSD +VHRDLA RN
Sbjct: 734 LRKHDG--EFTVIQ----------------LVGILRNIAAGMKYLSDMGYVHRDLAARNI 775
Query: 501 LINDDMVVKIADFGLSHKIY-LQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGV 559
L+N ++ K++DFGLS + D IP+RW E+I Y K+T SDVW+YG+
Sbjct: 776 LVNAQLICKVSDFGLSRVLEESSDSTYTTRGGKIPIRWTAPEAINYRKFTSASDVWSYGI 835
Query: 560 CLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
+WE+ S+ +PY+GM++++V+ + L P + P+ ++LM CW + ++RP F
Sbjct: 836 VMWEVMSYGERPYWGMSNQDVIHAVGTGYRLPAPMDCPQVQHELMLDCWKKDRNERPKFS 895
Query: 620 VIYQTLDNI 628
+ TLD +
Sbjct: 896 QVVATLDRM 904
>UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protein,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to p80 protein, partial -
Strongylocentrotus purpuratus
Length = 526
Score = 179 bits (436), Expect = 2e-43
Identities = 86/226 (38%), Positives = 128/226 (56%), Gaps = 15/226 (6%)
Query: 404 LADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXX 463
+ +FDHPN+V LLG+C +P+ ++ EYM G+L ++LR P E +
Sbjct: 1 MGNFDHPNVVSLLGICFKEKPLFIVLEYMEGGELKQFLR------DIRPTEEKPSSITMK 54
Query: 464 XXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIN---DDMVVKIADFGLSHKIY 520
I + +A G YL R+F+HRD+A RN L+ KIADFG++ IY
Sbjct: 55 DLLQ------ITQDVAQGCRYLESRRFIHRDIAARNILLTTKESGRAAKIADFGMARDIY 108
Query: 521 LQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEV 580
DYY+ +PV+WMP E+ +T ++DVWAYGV LWEI S PY GM+++EV
Sbjct: 109 RADYYRKGGQALLPVKWMPPEAFQDGIFTSKTDVWAYGVLLWEIISLGFMPYPGMSNQEV 168
Query: 581 VRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
++F+ + P + P+ V++LM QCW H P DRP F I ++++
Sbjct: 169 IQFVSAGERMNPPRSCPQPVFNLMSQCWRHIPEDRPPFTTILESIN 214
>UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77;
Eutheria|Rep: Proto-oncogene c-fes variant 4 - Homo
sapiens (Human)
Length = 752
Score = 179 bits (436), Expect = 2e-43
Identities = 101/293 (34%), Positives = 157/293 (53%), Gaps = 24/293 (8%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLD 396
PK +K +++ +G+G FG VF + L D TLVAVK ++ DL+
Sbjct: 480 PK-DKWVLNHEDLVLGEQIGRGNFGEVFSGR---LRADN--TLVAVKSCRETLPPDLKAK 533
Query: 397 FEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
F +EA +L + HPNIV+L+GVC +P+ ++ E + GD +LR T A + +
Sbjct: 534 FLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR-----TEGARLRVK 588
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
+ A+GM YL + +HRDLA RNCL+ + V+KI+DFG+S
Sbjct: 589 -------------TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMS 635
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
+ Y +PV+W E++ Y +Y+ ESDVW++G+ LWE FS PY ++
Sbjct: 636 REEADGVYAASGGSRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLS 695
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQ 629
+++ F++ L CP+ P V+ LM+QCW + P RP+F IYQ L +I+
Sbjct: 696 NQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 748
>UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1006
Score = 177 bits (432), Expect = 6e-43
Identities = 113/366 (30%), Positives = 184/366 (50%), Gaps = 34/366 (9%)
Query: 273 LLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTTG 332
LLLS+ G+G +L I+ + +N YSK S ++++ + Y
Sbjct: 589 LLLSVSGVGILLLISAAVFIISRR-RNKYSKTKQDSEEE-KHLNPGVKIYVDPFTYEDPD 646
Query: 333 AQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHD 392
++ ++++ ++I R +G G FG V + + + VA+K LK S
Sbjct: 647 QAIHEFAKEIDV--SSIHIERVIGMGEFGEVCSGRLR--VQGKREIYVAIKSLKAGYSDK 702
Query: 393 LQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAP 452
+ DF EA ++ FDHPNI++L GV +P+ ++ EYM G L+ +LR F
Sbjct: 703 QRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPLMIITEYMENGSLDAFLRKHDG--QFTV 760
Query: 453 VEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIAD 512
++ + R IASGM YLSD +VHRDLA RN L+N ++V K++D
Sbjct: 761 IQ----------------LVGMLRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSD 804
Query: 513 FGLSHKIY--LQDYYKGDEHDA--------IPVRWMPLESILYNKYTLESDVWAYGVCLW 562
FGLS + + Y E+ IP+RW E+I Y K+T SDVW+YG+ +W
Sbjct: 805 FGLSRVLEDDPEAAYTTRENTGTYLSPGGKIPIRWTAPEAIAYRKFTTASDVWSYGIVMW 864
Query: 563 EIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIY 622
E+ S+ +PY+ M +++V++ +++ L P + P ++ LM CW ++RP F I
Sbjct: 865 EVVSYGERPYWDMNNQDVIKAIEEGYRLPAPMDCPLVLHQLMLDCWERERAERPTFSQIL 924
Query: 623 QTLDNI 628
LD +
Sbjct: 925 NMLDKL 930
>UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 573
Score = 177 bits (432), Expect = 6e-43
Identities = 101/285 (35%), Positives = 152/285 (53%), Gaps = 21/285 (7%)
Query: 354 DLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIV 413
+LG G FG V + E + + E + + + REA +A DH NIV
Sbjct: 291 ELGAGTFGTVRLGVYRPKNGEPEVQCALKYLKQSEELPNQKAEILREADAMAALDHCNIV 350
Query: 414 KLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXX 473
+L G+C +G P+CL+ E +G LN++LR T PV
Sbjct: 351 RLFGIC-VGDPICLVMELARQGPLNKFLRKRPTF----PV---------------IKILN 390
Query: 474 IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL-QDYYKGDEHDA 532
+A Q++ GM YL + +FVHRDLA RN L+ DD VKI+DFG+S I +YYK +
Sbjct: 391 MALQVSRGMAYLEEVRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGAGSEYYKAETAGR 450
Query: 533 IPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLAC 592
P++W E I Y K+ +SDVW+YGV +WE FSF +PY G+ +++++ L+ L
Sbjct: 451 WPLKWYAPECIYYAKFDSKSDVWSYGVTVWEAFSFGAKPYAGLKGQDIMQMLEGNQRLDS 510
Query: 593 PDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILERGRT 637
P+ P+ +YD+M +CW P DRP+F + L +I + L++ T
Sbjct: 511 PEKCPQPIYDIMLRCWAWRPEDRPSFSELSSMLKDIYVYLQQNDT 555
>UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2;
Hydra vulgaris|Rep: Receptor protein-tyrosine kinase -
Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 891
Score = 177 bits (432), Expect = 6e-43
Identities = 97/252 (38%), Positives = 133/252 (52%), Gaps = 4/252 (1%)
Query: 378 TLVAVKMLKDEASHDLQLDFEREACLLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGD 436
T VAVK LK AS D E +L +HPNIV LLG C +C + EY G+
Sbjct: 562 TFVAVKTLKSSASDVEYRDLSSEIKVLIHLGEHPNIVNLLGSCTKDGRLCAIMEYCPHGN 621
Query: 437 LNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLA 496
L +LR V S ++ + A QIASGML+LS++K VHRDLA
Sbjct: 622 LVGFLRPRRHVFS---LQWEKQALNYDEDFCWLDAATAAFQIASGMLFLSEKKLVHRDLA 678
Query: 497 TRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWA 556
RN L+ D ++K+ADFGL+ IYL Y + +PV+WM ES+ YT++SDVW+
Sbjct: 679 ARNVLVGPDYIMKLADFGLARDIYLSGVYIKESCGILPVKWMAPESLFDKVYTIKSDVWS 738
Query: 557 YGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRP 616
+G+ LWEI + PY G+ E++ +L + P P +Y++M QCW P +RP
Sbjct: 739 FGIVLWEICTMGGSPYPGLPTEDLFEYLTAGKRMCQPVTCPDELYEIMLQCWQERPEERP 798
Query: 617 NFRVIYQTLDNI 628
F I L I
Sbjct: 799 WFHEIVSQLQRI 810
Score = 35.9 bits (79), Expect = 3.3
Identities = 14/30 (46%), Positives = 23/30 (76%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLI 372
EFPR+ + ++R +G GAFG+V+ A A G++
Sbjct: 491 EFPRHRLDFVRVIGSGAFGQVWFAHARGIL 520
>UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 177 bits (431), Expect = 7e-43
Identities = 104/284 (36%), Positives = 148/284 (52%), Gaps = 22/284 (7%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E P I + ++G G FG V++ P +AVK LK +S ++ DF EA
Sbjct: 529 EIPPKYIKLVEEIGGGEFGTVYKGMWNERKPPVP---IAVKTLKPGSSDKMRDDFLTEAS 585
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
++ F HPN++KL GV P ++ E+M G L YLR S +
Sbjct: 586 IMGQFHHPNVIKLYGVITKVEPAMIIMEFMDNGSLYYYLRHNDEKLSLQQL--------- 636
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ 522
+A +A+GM YLS+ +VHRDLA RN L++ D V K+ADFGLS +
Sbjct: 637 ---------LKMACGVAAGMQYLSEVGYVHRDLAARNILVSKDEVCKVADFGLSRET-TN 686
Query: 523 DYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVR 582
D Y + IPVRW E+I Y K+T SDVW+YGV LWE+ S+ QPY ++ V+
Sbjct: 687 DEYDVKKGGKIPVRWTAPEAISYRKFTTASDVWSYGVLLWEVMSYGQQPYEDWDNQMVLD 746
Query: 583 FLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
L+ L P + P VY+LM+ CW+ +DRP F+ + + LD
Sbjct: 747 KLESGYRLQKPKDCPSTVYELMQSCWSAEHTDRPTFKELVRLLD 790
>UniRef50_Q25198 Cluster: Receptor tyrosine kinase 90; n=1; Hydra
vulgaris|Rep: Receptor tyrosine kinase 90 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 848
Score = 177 bits (430), Expect = 1e-42
Identities = 107/292 (36%), Positives = 156/292 (53%), Gaps = 23/292 (7%)
Query: 329 HTTGAQLNP--KLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLK 386
H GA P +EKL F N+ I LG G FG+VF+A A G+ + TLVAVK+ +
Sbjct: 566 HLLGASDIPLVSIEKLIFNYENLQEIIVLGYGKFGKVFKAYAKGICEEGTDTLVAVKVFE 625
Query: 387 DEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACST 446
+ +++ F +E L F + +V+LLG+ P C++ EY GDL EYL+
Sbjct: 626 ETPVNNVLSAFNKETEDLMQFQNSYVVRLLGLVRES-PFCIITEYSELGDLKEYLQTNKN 684
Query: 447 VTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDM 506
+S A + + IA GM YL+ +VHRDLA RNC++
Sbjct: 685 TSSSARLH-------------------MCTCIAKGMSYLATLHYVHRDLAARNCILFSQN 725
Query: 507 VVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFS 566
VK++ L + Y DYY + A PVRW+ ESI N Y ++DVW++ V +WEIFS
Sbjct: 726 EVKVSFLSLCNTTYKDDYYLLNNLLA-PVRWLAPESIRENIYNEKTDVWSFSVTMWEIFS 784
Query: 567 FALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
+QP++G+++EEVV + + L P N P+ +Y +M +CW N DRP F
Sbjct: 785 SEVQPFYGVSNEEVVNRIGKDLQLTIPSNCPKTLYKIMTRCWLVNAFDRPTF 836
>UniRef50_Q17HL3 Cluster: Discoidin domain receptor; n=3;
Culicidae|Rep: Discoidin domain receptor - Aedes aegypti
(Yellowfever mosquito)
Length = 901
Score = 177 bits (430), Expect = 1e-42
Identities = 106/306 (34%), Positives = 158/306 (51%), Gaps = 27/306 (8%)
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
L+ E+PR+ ++ + LG G FG + + G + LVAV L+ AS ++ +F
Sbjct: 600 LQLSEYPRDKLVIVEKLGCGVFGELHLCETKGYSSN----LVAVSTLRPGASEHVKKEFR 655
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
+A L+ + PN+ KL+G C P+C++ +Y DLN++L+ + T V+H
Sbjct: 656 AKAKQLSRLNDPNVAKLIGACLKDEPICIVLDYKFGTDLNQFLQEHTAETGTL-VQHNSL 714
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG--LS 516
IA QIASGM YL VHRDLA R+CL+ + +KI G ++
Sbjct: 715 SYGCLIY--------IATQIASGMKYLEQMNVVHRDLAARSCLVGPQLEIKICTLGTVIN 766
Query: 517 HKIYLQDYYK----GDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL-QP 571
Y DY G + +P+RWM ES+L K+T +SDVW++ V LWEI +FA QP
Sbjct: 767 RIAYPADYCHLEGAGRQSQPMPIRWMAWESVLMGKFTSKSDVWSFAVTLWEILTFAREQP 826
Query: 572 YFGMTHEEVVRFL-------KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQT 624
+ ++ E+V+ + K L P PR +YDLM +CW N + RPNFR I+
Sbjct: 827 FENLSDEKVIENIGHMYQDNKKHIQLPIPVGCPREIYDLMCECWQRNENSRPNFREIHLF 886
Query: 625 LDNIQL 630
L L
Sbjct: 887 LQRKNL 892
>UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27;
Fungi/Metazoa group|Rep: Tyrosine-protein kinase FRK -
Homo sapiens (Human)
Length = 505
Score = 177 bits (430), Expect = 1e-42
Identities = 99/291 (34%), Positives = 154/291 (52%), Gaps = 27/291 (9%)
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
+++ E RN+I ++ LG G FG V++ P VAVK LK S D DF
Sbjct: 224 VDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTP------VAVKTLKP-GSMDPN-DFL 275
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
REA ++ + HP +++L VC + P+ ++ E M G L EYL+
Sbjct: 276 REAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQ---------------- 319
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSH- 517
+A Q+ASGM YL R ++HRDLA RN L+ + + K+ADFGL+
Sbjct: 320 -NDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARV 378
Query: 518 -KIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
K+ +D Y+ +PV+W E+I NK++++SDVW++G+ L+EI ++ PY GMT
Sbjct: 379 FKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMT 438
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
+V++ L L P N P+ Y++M +CWN P +RP F + L++
Sbjct: 439 GAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLED 489
>UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n=2;
Caenorhabditis briggsae|Rep: Dauer abnormal formation-2
precursor - Caenorhabditis briggsae
Length = 1807
Score = 176 bits (429), Expect = 1e-42
Identities = 99/284 (34%), Positives = 151/284 (53%), Gaps = 9/284 (3%)
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVF--QAKAPGLIPDEEFTLVAVKMLKDEASHDLQ-L 395
++ E + ++ +GQG FG+V+ Q K I + F AVK+ +EA+ L+ +
Sbjct: 1193 IDDWELEKESVTLGEVIGQGTFGKVYLAQGKKCVSIRGDAFGPCAVKINTEEAAESLENM 1252
Query: 396 DFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEH 455
++ EA ++ +F IVKL GV + P ++ E+M G+L +YLRA F
Sbjct: 1253 NYLMEANVMKNFKTTFIVKLFGVVSSVHPAWVVMEFMELGNLRDYLRAKREEEVFD---- 1308
Query: 456 REXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGL 515
E A QI GM YL KF HRDLA RNC+I+ +VKI DFG+
Sbjct: 1309 -ENNCNFYNIVPREKICEWAAQICDGMAYLESLKFCHRDLAARNCMIDKTELVKIGDFGM 1367
Query: 516 SHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGM 575
+ ++ DYYK +PVRWM ES+ K+ +SD+W++GV L+E+ + QPY G+
Sbjct: 1368 ARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDIWSFGVVLYELITLGAQPYIGL 1427
Query: 576 THEEVVRFL-KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
+++EV+ ++ V+ PD Y +MK CW + P DRP F
Sbjct: 1428 SNDEVLNYIGMARKVIKKPDCCSEYWYKIMKMCWRYAPRDRPTF 1471
>UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 176 bits (429), Expect = 1e-42
Identities = 105/303 (34%), Positives = 159/303 (52%), Gaps = 17/303 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLI---PDEEFT---LVAVKMLKD----EASHD 392
EFP +I + LGQGAFG+V +A+A G+ P ++ KM + AS
Sbjct: 26 EFPEERLILGKVLGQGAFGQVLRAEAIGMDNFNPRDKSADGLKTRSKMRRSLRGKGASES 85
Query: 393 LQLDFEREACLLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFA 451
D E +L +H NIV +LG C GR + ++ E+ G+L +LRA V +
Sbjct: 86 DYKDLASELKILIHLGEHKNIVNVLGACTRGRRLMVIIEFAPYGNLLSFLRARREV--YQ 143
Query: 452 PVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIA 511
P + + Q++ G+ +L+ RK VHRDLA RN L+ D V+K++
Sbjct: 144 PT-WTKTTNDPEKNYTLVDLTMASYQVSRGVEFLASRKCVHRDLAARNVLVGPDYVMKVS 202
Query: 512 DFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQP 571
DFGL+ IY D Y + +PV+WM LES+ YT +SDVW++G+ LWEI + P
Sbjct: 203 DFGLARDIYQDDLYVKNTSGLLPVKWMALESLFDRVYTEKSDVWSFGILLWEIMTLGGTP 262
Query: 572 YFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLI 631
Y G+ E+++ +L + +A P N P +Y +M+ CW P RP+F V+ D + +
Sbjct: 263 YPGLPTEQLLDYLSEGQRMAQPQNCPLEIYTIMRDCWMQLPEQRPHFNVL---ADRLGKV 319
Query: 632 LER 634
LER
Sbjct: 320 LER 322
>UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 7 SCAF14601, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 761
Score = 176 bits (428), Expect = 2e-42
Identities = 99/279 (35%), Positives = 151/279 (54%), Gaps = 27/279 (9%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V + + IP ++ VA+K LK + + DF EA ++ F HPNI+
Sbjct: 415 IGAGEFGEVCRGRLK--IPGKKENYVAIKTLKGGYTDKQRRDFLSEASIMGQFQHPNIIH 472
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV P+ +L E+M G L+ +LR + F P++ +
Sbjct: 473 LEGVITASCPVMILTEFMENGALDSFLRLNDS--QFTPIQ----------------LVGM 514
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDY-----YKGDE 529
R IASGM YLS+ +VHRDLA RN LIN ++V K++DFGLS +LQ+ Y
Sbjct: 515 LRGIASGMKYLSEMSYVHRDLAARNILINSNLVCKVSDFGLSR--FLQENSSDPTYTSSL 572
Query: 530 HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV 589
IP+RW E+I + K+T SDVW+YG+ +WE+ SF +PY+ M++++V+ ++ +
Sbjct: 573 GGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYR 632
Query: 590 LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L P + P ++ LM CW + S RP F + LD +
Sbjct: 633 LPPPPDCPTHLHQLMLDCWQKDRSARPRFADLVSALDKL 671
>UniRef50_Q95ZV7 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 797
Score = 176 bits (428), Expect = 2e-42
Identities = 103/295 (34%), Positives = 157/295 (53%), Gaps = 36/295 (12%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E R+ +I + +GQG FG V + E VAVK L + D + F RE
Sbjct: 521 EIARDKLICVSRIGQGEFGEVDLCQL-------ENRKVAVKKLHGISQAD-EFSFHREIR 572
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
+L HPN+V+++GVC I +P+ + EYM GDL Y+ T+ + +
Sbjct: 573 VLGSLKHPNVVEVVGVCTIQKPILCIMEYMENGDLKSYILKNPTIQTSQCIS-------- 624
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ 522
I Q+A+G+ YL FVHRD+A RNCL++ + VKIADFG++ +Y Q
Sbjct: 625 -----------ICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQ 673
Query: 523 DYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQ-PYFGMTHEEVV 581
+YYK + +P+RWM E++L K++ SDVW +GV +WEIFS + PY MT ++VV
Sbjct: 674 EYYKVEGKFVLPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVV 733
Query: 582 RFLKD-------ENVLACPDNTPRCVY-DLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L+ + VL+ P P +Y + + CWN+ S RP+F ++ L ++
Sbjct: 734 ENLQSMSSTGSLKQVLSRPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQSL 788
>UniRef50_Q674V1 Cluster: Vascular endothelial growth factor receptor;
n=1; Podocoryne carnea|Rep: Vascular endothelial growth
factor receptor - Podocoryne carnea
Length = 1254
Score = 176 bits (428), Expect = 2e-42
Identities = 93/254 (36%), Positives = 136/254 (53%), Gaps = 4/254 (1%)
Query: 376 EFTLVAVKMLKDEASHDLQLDFEREACLLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGK 434
E ++VAVK LKD+A+ D E +L +H NIV LLG C + ++ E +
Sbjct: 891 EKSMVAVKTLKDDAAEGEYKDLASELKILIHLGEHKNIVNLLGACTTNGKLYVILECCPR 950
Query: 435 GDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRD 494
G+L +LR +F PV + I Q+A M +L +K VHRD
Sbjct: 951 GNLLTFLRGKRE--TFQPV-WTKYDTDMENEFTYIDLLMIVIQVAKRMDFLQSQKCVHRD 1007
Query: 495 LATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDV 554
LA RN L+ D ++KIADFGL+ IY ++Y + +PV+WM ES+ YT SD+
Sbjct: 1008 LAARNVLVGPDYIMKIADFGLARDIYKDEFYLKETTGLLPVKWMAPESLFDKVYTSMSDI 1067
Query: 555 WAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSD 614
W+YG+ LWE F+ PY G+ E++ FL+D + P+ P+ V+++M CW +P D
Sbjct: 1068 WSYGIVLWEAFTLGGSPYPGLPTEDLFGFLEDGKRMERPEICPKSVFEIMSDCWTKSPYD 1127
Query: 615 RPNFRVIYQTLDNI 628
RP F IY L N+
Sbjct: 1128 RPMFSQIYDRLTNV 1141
Score = 37.1 bits (82), Expect = 1.4
Identities = 16/29 (55%), Positives = 22/29 (75%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGL 371
EFPR+ I I+ LG GAFG+V+ A+A G+
Sbjct: 816 EFPRSKISLIKTLGSGAFGQVWLAEAEGI 844
>UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 743
Score = 175 bits (426), Expect = 3e-42
Identities = 103/276 (37%), Positives = 153/276 (55%), Gaps = 22/276 (7%)
Query: 354 DLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIV 413
+LGQG FG V + G D + VAVK L+ ++ + +F REA ++ +HP IV
Sbjct: 470 ELGQGEFGSVLKGLYKGA--DGKKIEVAVKTLRLDSQGHGEKEFAREAGIMVTLNHPCIV 527
Query: 414 KLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXX 473
KL+G+ G+PM ++ E + G L +YL E ++
Sbjct: 528 KLIGITN-GKPMMMVQELISMGALVDYL-----------YERKQPIPDVLTLKLW----- 570
Query: 474 IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ-DYYKGDEHDA 532
A +IASGM+YL ++FVHRDLA RN L+ VKI+DFGLS + DYYK +
Sbjct: 571 -AAEIASGMMYLETKRFVHRDLAARNILVQSMKQVKISDFGLSRAVGANSDYYKASQGGR 629
Query: 533 IPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV-LA 591
PV+W ESI + ++ SDVW+YG+ LWE+FSF PY MT EV+ +++ N L
Sbjct: 630 WPVKWYAPESINFGTFSHASDVWSYGITLWEMFSFGDAPYGDMTGAEVLDRVENLNYRLE 689
Query: 592 CPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
CP + P +Y+LM +CW+ P++RP F +Y + ++
Sbjct: 690 CPRDCPSSIYELMLRCWSLEPNERPTFAQLYDSFES 725
>UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1;
Tetraodon nigroviridis|Rep: Tyrosine-protein kinase
receptor - Tetraodon nigroviridis (Green puffer)
Length = 1419
Score = 175 bits (425), Expect = 4e-42
Identities = 90/226 (39%), Positives = 124/226 (54%), Gaps = 13/226 (5%)
Query: 413 VKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXX------ 466
V+LLGV + G+P ++ E M GDL YLR+ AP R
Sbjct: 1101 VRLLGVVSKGQPTLVVMELMTNGDLKSYLRSLRPDAEVAPPHTRHPVCFWVVFFHPQSRN 1160
Query: 467 -------XXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+A +IA GM YL+ +KFVHRDLA RNC++ D VKI DFG++ I
Sbjct: 1161 NPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVGHDFTVKIGDFGMTRDI 1220
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y DYY+ +PVRWM ES+ +T SD W++GV LWEI + + QPY G+++E+
Sbjct: 1221 YETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLSEQPYQGLSNEQ 1280
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
V++F+ D L PDN P +Y+LM+ CW +NP RP F I + L
Sbjct: 1281 VLKFVMDGGYLDRPDNCPDRLYNLMQMCWQYNPKMRPTFLEIIEML 1326
Score = 50.8 bits (116), Expect = 1e-04
Identities = 26/74 (35%), Positives = 43/74 (58%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E PR I +R+LGQG FG V++ A +I E T VAVK + + A+ +++F
Sbjct: 1001 DEWEVPREKISILRELGQGTFGMVYEGLAKDIIKGEGETHVAVKTVNESANLRQRIEFLN 1060
Query: 400 EACLLADFDHPNIV 413
EA ++ F ++V
Sbjct: 1061 EASVMKAFSCHHVV 1074
>UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1
precursor; n=37; Deuterostomia|Rep: Tyrosine-protein
kinase receptor Tie-1 precursor - Homo sapiens (Human)
Length = 1138
Score = 175 bits (425), Expect = 4e-42
Identities = 111/292 (38%), Positives = 154/292 (52%), Gaps = 17/292 (5%)
Query: 337 PKL--EKLEFPR---NNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTL-VAVKMLKDEAS 390
PKL E L +P +I + +G+G FG+V +A +I + + A+KMLK+ AS
Sbjct: 822 PKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRA----MIKKDGLKMNAAIKMLKEYAS 877
Query: 391 HDLQLDFEREACLLADFDH-PNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTS 449
+ DF E +L H PNI+ LLG C + + EY G+L ++LR S V
Sbjct: 878 ENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRK-SRVLE 936
Query: 450 FAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVK 509
P RE A A+GM YLS+++F+HRDLA RN L+ +++ K
Sbjct: 937 TDPAFAREHGTASTLSSRQLLR--FASDAANGMQYLSEKQFIHRDLAARNVLVGENLASK 994
Query: 510 IADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFAL 569
IADFGLS ++ Y +PVRWM +ES+ Y+ YT +SDVW++GV LWEI S
Sbjct: 995 IADFGLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGG 1051
Query: 570 QPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVI 621
PY GMT E+ L + P N VY+LM+QCW P +RP F I
Sbjct: 1052 TPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQI 1103
>UniRef50_O16131 Cluster: Insulin receptor homolog precursor; n=2;
Caenorhabditis elegans|Rep: Insulin receptor homolog
precursor - Caenorhabditis elegans
Length = 1846
Score = 174 bits (424), Expect = 5e-42
Identities = 93/279 (33%), Positives = 149/279 (53%), Gaps = 8/279 (2%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIP--DEEFTLVAVKMLKDEASHDLQLDFERE 400
E +++++ + G+G+FG+V+ ++ + F A+K+ D+ + L++ E
Sbjct: 1240 ELRQDDVVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLME 1299
Query: 401 ACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXX 460
A ++ +F IV+L GV + +P ++ E M G+L +YLR+ F E
Sbjct: 1300 ANIMKNFKTNFIVQLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVF-----NETDC 1354
Query: 461 XXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIY 520
A QI GM YL KF HRDLA RNC+IN D VKI DFG++ ++
Sbjct: 1355 NFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLF 1414
Query: 521 LQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEV 580
DYYK +PVRWM ES+ K+ +SDVW++GV L+E+ + QPY G++++EV
Sbjct: 1415 YHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEV 1474
Query: 581 VRFL-KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
+ ++ V+ P+ Y +MK CW ++P DRP F
Sbjct: 1475 LNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTF 1513
>UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1072
Score = 173 bits (422), Expect = 9e-42
Identities = 101/289 (34%), Positives = 153/289 (52%), Gaps = 25/289 (8%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E +NI R +G G FG V + + + VA+K LK S + DF EA
Sbjct: 717 EIDASNIRIERVIGAGEFGEVCSGRLR--VQGKREIYVAIKSLKAGYSDKQRRDFLSEAS 774
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
++ FDHPNI++L GV +P+ ++ E+M G L+ +L+ F ++
Sbjct: 775 IMGQFDHPNIIRLEGVVTRCKPVMIITEFMENGSLDTFLKKHDG--QFTVIQ-------- 824
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ 522
+ R IASGM YLSD +VHRDLA RN L+N ++V K++DFGLS L+
Sbjct: 825 --------LVGMLRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGLSR--VLE 874
Query: 523 DYYKG---DEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
D + IP+RW E+I Y K+T SDVW+YG+ +WE+ S+ +PY+ M++++
Sbjct: 875 DDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQD 934
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
V++ + + L P + P ++ LM CW SDRP F I LD +
Sbjct: 935 VIKAIDEGYRLPAPMDCPVVLHQLMLDCWEKGRSDRPKFGQIVTILDKL 983
>UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 312
Score = 173 bits (422), Expect = 9e-42
Identities = 100/304 (32%), Positives = 155/304 (50%), Gaps = 15/304 (4%)
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
+++ E P ++ +LG+GAFG+VF+ L P++ K ++ +++ + E
Sbjct: 2 IDQWEVPYEKVLLDDELGEGAFGKVFKGTLVEL-PEQSSKYSIAKSMRRKSTKPEERVLE 60
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRA-----CSTVTSFAPV 453
+ + NIV +LG C + PM L+ EY+ GDL YLR S T P
Sbjct: 61 GNSADERRGNR-NIVNMLGCCTLTEPMFLIVEYLPYGDLLHYLRKRRGKLVSLYTGDKPQ 119
Query: 454 EHREXXXXXXXXX-------XXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDM 506
R A Q+A GM YL+ R FVHRDLA RN L+ D+
Sbjct: 120 SERGAAENDGIEDEEEDDGISSGDLMAFAWQVAQGMEYLARRGFVHRDLAARNVLVGDNK 179
Query: 507 VVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFS 566
V K+ADFGL+ +Y +D Y+G +P++WM +E+I +T +SDVWAYGV LWE+ +
Sbjct: 180 VAKVADFGLTRHMY-EDLYQGKTSRKLPLKWMSIEAIFDQAFTSQSDVWAYGVFLWELVT 238
Query: 567 FALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
PY + + E+++ LK+ + PD +Y +M CW P DRP F + TL+
Sbjct: 239 LGGTPYPTIGNRELLKLLKEGYRMEKPDMCNDDLYTIMLSCWKDKPEDRPTFENLRSTLE 298
Query: 627 NIQL 630
++ +
Sbjct: 299 DLMM 302
>UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hydra
vulgaris|Rep: Tyrosine-protein kinase HTK16 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 757
Score = 173 bits (422), Expect = 9e-42
Identities = 109/280 (38%), Positives = 152/280 (54%), Gaps = 22/280 (7%)
Query: 346 RNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLA 405
+ +I + ++LG G FG V K L P + VA+K L + + +F REA +++
Sbjct: 481 KESISFGKELGVGEFGSVI--KGIWLSPGGKEINVAMKTLHKDKMVQGEKEFLREALVMS 538
Query: 406 DFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXX 465
+HP IV LLGVC +G PM L+ E + G L +YL + P E +E
Sbjct: 539 QLNHPCIVSLLGVC-LGPPMILVQELVEMGALLDYLM------DYQP-EIQEVDLKLW-- 588
Query: 466 XXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL-QDY 524
A QIA GM+YL ++FVHRDLA RN L+ + VKI+DFGLS + DY
Sbjct: 589 ---------ASQIAFGMMYLELKRFVHRDLAARNILLANKKQVKISDFGLSRAVGTGSDY 639
Query: 525 YKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFL 584
Y+ + PVRW ESI Y ++ +SDVW+YG+ LWE+F+F PY MT EVV FL
Sbjct: 640 YQAKQGGRWPVRWYAPESINYGTFSTKSDVWSYGITLWEMFTFGDLPYGEMTGNEVVSFL 699
Query: 585 KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQT 624
+ L PD P Y +M CW+ +P+ RP F ++ T
Sbjct: 700 EHCGRLEKPDECPIHTYSIMLSCWHIDPNKRPTFNELHST 739
>UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase
FER; n=109; root|Rep: Proto-oncogene tyrosine-protein
kinase FER - Homo sapiens (Human)
Length = 822
Score = 173 bits (422), Expect = 9e-42
Identities = 96/293 (32%), Positives = 158/293 (53%), Gaps = 25/293 (8%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLD 396
PK +K ++I LG+G FG V++ G + D+ T VAVK K++ +L++
Sbjct: 551 PKDKKWILSHEDVILGELLGKGNFGEVYK----GTLKDK--TSVAVKTCKEDLPQELKIK 604
Query: 397 FEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
F +EA +L +DHPNIVKL+GVC +P+ ++ E + GD +LR +
Sbjct: 605 FLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQL--- 661
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
+ A+GMLYL + +HRDLA RNCL+ ++ V+KI+DFG+S
Sbjct: 662 ---------------VKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMS 706
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
+ Y IP++W E++ Y +Y+ ESDVW++G+ LWE FS + PY GMT
Sbjct: 707 RQED-GGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMT 765
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQ 629
+++ ++ ++ P + P + +M +CW++ P +RP F + + L I+
Sbjct: 766 NQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIK 818
>UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=311;
Eumetazoa|Rep: Ephrin type-B receptor 2 precursor - Homo
sapiens (Human)
Length = 1055
Score = 173 bits (422), Expect = 9e-42
Identities = 96/279 (34%), Positives = 148/279 (53%), Gaps = 27/279 (9%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V +P + VA+K LK + + DF EA ++ FDHPN++
Sbjct: 627 IGAGEFGEVCSGHLK--LPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 684
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV P+ ++ E+M G L+ +LR F ++ +
Sbjct: 685 LEGVVTKSTPVMIITEFMENGSLDSFLR--QNDGQFTVIQ----------------LVGM 726
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQD-----YYKGDE 529
R IA+GM YL+D +VHRDLA RN L+N ++V K++DFGLS +L+D Y
Sbjct: 727 LRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSR--FLEDDTSDPTYTSAL 784
Query: 530 HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV 589
IP+RW E+I Y K+T SDVW+YG+ +WE+ S+ +PY+ MT+++V+ ++ +
Sbjct: 785 GGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYR 844
Query: 590 LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L P + P ++ LM CW + + RP F I TLD +
Sbjct: 845 LPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 883
>UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1
precursor; n=2; Dugesia japonica|Rep: Fibroblast growth
factor receptor 1 precursor - Dugesia japonica
(Planarian)
Length = 854
Score = 173 bits (421), Expect = 1e-41
Identities = 107/295 (36%), Positives = 158/295 (53%), Gaps = 15/295 (5%)
Query: 341 KLEFPRNNI-IYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
K EFPR + I + LG+GAFG V++ A + VAVKM++D+ S DF +
Sbjct: 542 KWEFPREKLKITNKKLGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRDDFSDSNVHDFVK 601
Query: 400 EACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
E ++ HPN+++LLG+C P+ ++ E G+L +++RA + S
Sbjct: 602 EMEIMKHIGRHPNVIQLLGLCTQKGPLRVIVELAPYGNLRDFVRAKNKKYS--------K 653
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
+ QIA GM YL+ R VHRDL+ RN L+ + +KIADFGL+
Sbjct: 654 SKKIIGNFTSSILCTYSLQIARGMTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTR- 712
Query: 519 IYLQDYYKGDEHDAI-PVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTH 577
+ DYY + D I PV+WM E++L KYT +SDVW+YG+ LWEIF+ PY +
Sbjct: 713 --IVDYYYRKKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILP 770
Query: 578 EEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL-DNIQLI 631
E+VV ++ P+ +Y LM+ CW+ + +RPNF I + L D IQ I
Sbjct: 771 EKVVDLIRKGFQNPKPELANFEIYRLMQHCWSLSSENRPNFFEIVEILIDIIQRI 825
>UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberites
domuncula|Rep: Receptor tyrosine kinase - Suberites
domuncula (Sponge)
Length = 715
Score = 173 bits (420), Expect = 2e-41
Identities = 103/287 (35%), Positives = 159/287 (55%), Gaps = 20/287 (6%)
Query: 354 DLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADF-DHPNI 412
DLG GAFG V +A+ I + ++VAVKMLK+ AS + + D E +L +H N+
Sbjct: 392 DLGSGAFGVVKKAELFDPI-SQTTSIVAVKMLKESASTEDEKDIIMELKVLYHVGEHCNV 450
Query: 413 VKLLGVCAIGRPMCLLFEYMGKGDLNEYLRAC-STVTSFAPVEHREXXXXXXXXXXXXXX 471
V LG + L+ EY +G+L ++LR+ + S V+++
Sbjct: 451 VSFLGASVHKGKLHLIVEYCERGNLLQFLRSKRGDMKSPLSVQNQ--------------- 495
Query: 472 XXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHD 531
IA Q+A+GM YL+ ++ +HRDLA RN LI D+ +K+ADFGL+ K+Y Y +
Sbjct: 496 VAIASQVANGMAYLASKRCIHRDLAARNVLITKDLTLKVADFGLARKMYSSVYRPSGKR- 554
Query: 532 AIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLA 591
+P++WM E IL T +SDVW++G+ LWEI + PY G + V+R +++ +
Sbjct: 555 -LPIKWMAPEGILDGVCTSKSDVWSFGILLWEIMTLGRTPYPGRSAHWVIRDIENGYRMP 613
Query: 592 CPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILERGRTH 638
PD P +Y +MK CW NP RP F + +LDN+ + L+ G+ H
Sbjct: 614 QPDGCPDKLYSVMKCCWQMNPIARPEFTELTNSLDNVVMELDSGQLH 660
>UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor
precursor; n=1; Hydra vulgaris|Rep: Fibroblast growth
factor receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 816
Score = 173 bits (420), Expect = 2e-41
Identities = 121/381 (31%), Positives = 182/381 (47%), Gaps = 29/381 (7%)
Query: 251 REKDNIKGSNLIMENYFTPTFVLLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSRR 310
R KD K SN+ NY P ++L++G +G+ ++ + S
Sbjct: 396 RSKDKFKNSNI---NYIKPLETVILNLGDNNT----SGVTMVTSVSASYASRRFRHSLNN 448
Query: 311 NLQNMDIDLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPG 370
NL N DK NL A KLE+LE + + LG+GAFGRVF+A A
Sbjct: 449 NLIN-----DKQKLNLKIAPDPAW-EIKLEQLE---TDCL----LGEGAFGRVFRATARD 495
Query: 371 LIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFD-HPNIVKLLGVCAIGRPMCLLF 429
L VAVKMLK++ DF E ++ H NI+ LL V + + ++
Sbjct: 496 LPNHTGVQTVAVKMLKEDCCEQDLKDFISEIEVMKSIGKHINILNLLAVSSQQGKLYIVV 555
Query: 430 EYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRK 489
EY G+L +L+ PV + Q+A GM +L+ +K
Sbjct: 556 EYCRHGNLRSFLK------DNRPV--MQANSVITKKITLYDLTSFCLQVARGMNFLASKK 607
Query: 490 FVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYT 549
+HRD+A RN L+ + ++KIADFGL+ I+ QDYY+ +PV+WM +E++ YT
Sbjct: 608 CIHRDIAARNVLVGEGYLMKIADFGLARDIHEQDYYRKCTDGRLPVKWMAIEALFDRVYT 667
Query: 550 LESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWN 609
+SD+W++G+ WEI +F PY G+ E++ LK + P N +Y LM CW
Sbjct: 668 TQSDIWSFGILAWEIVTFGGSPYPGIALEKLFDLLKQGYRMERPLNCTDDMYTLMLNCWK 727
Query: 610 HNPSDRPNFRVIYQTLDNIQL 630
PS RP F + + L+ + L
Sbjct: 728 EIPSKRPTFSQLIEDLERMLL 748
>UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,
isoform B; n=3; Endopterygota|Rep: PREDICTED: similar to
CG8874-PB, isoform B - Tribolium castaneum
Length = 801
Score = 172 bits (419), Expect = 2e-41
Identities = 94/289 (32%), Positives = 154/289 (53%), Gaps = 26/289 (8%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
E+ E ++++ + +G+G FG V++A+ +VAVK + D + F +
Sbjct: 530 ERWELNNDDVVLLDKIGRGNFGDVYRAQLKN-----SNDVVAVKTCRVTLPEDHKKKFLQ 584
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
E +L +DHPNIVKL+G+C +P+ ++ E + G L +LR + +T ++
Sbjct: 585 EGRILKQYDHPNIVKLIGICVQKQPIMIVMELVPGGSLLTFLRKKTALTDAQLMK----- 639
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ A+GM YL + +HRDLA RNCL+ + VVKI+DFG+S +
Sbjct: 640 --------------MCLDAAAGMRYLESKNCIHRDLAARNCLVGYNNVVKISDFGMSREE 685
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
++Y D IP++W E++ + KYT DVW+YG+ WEIFS PY G+++ +
Sbjct: 686 --EEYIVSDGMKQIPIKWTAPEALNFGKYTSLCDVWSYGILCWEIFSRGGTPYSGLSNSK 743
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ + PDNTP +Y LM +CW + P +RPNF IY ++ +
Sbjct: 744 AREKIDAGYRMPAPDNTPDEMYRLMLRCWEYKPENRPNFEQIYTVVETL 792
>UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus
variegatus|Rep: Focal adhesion kinase - Lytechinus
variegatus (Sea urchin)
Length = 1006
Score = 172 bits (419), Expect = 2e-41
Identities = 97/292 (33%), Positives = 153/292 (52%), Gaps = 23/292 (7%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLD 396
P + E R + + +GQG FG V + I +E VAVK K E++ L
Sbjct: 426 PAAKDYEISRELVTLVETIGQGQFGDVHKGI---YIDQDEKVEVAVKTCKVESTQALGER 482
Query: 397 FEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
F EA ++ FDHP+I+KL+GVC P+ ++ E G++ +L+ H+
Sbjct: 483 FLEEAYIMKQFDHPHIIKLIGVCT-DPPIWIVMELAPFGEMRMFLQT-----------HK 530
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
E A Q++ + YL +KFVHRD+A RN L+ VK+ DFGLS
Sbjct: 531 EELTLASLILY-------AYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLS 583
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
++ YYK + +P++WM ESI + ++T SDVW +GVC+WEI + ++P+ G+
Sbjct: 584 RLLHDHSYYKASK-GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVK 642
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ EV+ +++ L P P +Y +M CW++ PS RPNF+ + L+ I
Sbjct: 643 NNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRLNEI 694
>UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1002
Score = 172 bits (419), Expect = 2e-41
Identities = 103/275 (37%), Positives = 150/275 (54%), Gaps = 24/275 (8%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G+G FG V + K ++ + T VAVK LK AS +F REAC +A F PNI++
Sbjct: 621 IGRGEFGEVCRGK---MLTGKTTTSVAVKRLKHGASLIDHTNFLREACTMAQFKDPNIIQ 677
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV P ++ E+M G L+++L+A S + + +
Sbjct: 678 LKGVVTKSIPAMIITEFMEHGSLDKFLQARSGQPTVLQL------------------LEM 719
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL--QDYYKGDEHDA 532
R IASGM YLS K+VHRDLA RN L+N +V K++DFGLS + Q Y +
Sbjct: 720 LRGIASGMKYLSSMKYVHRDLAARNILVNSQLVCKVSDFGLSRTLENDPQATYT-TQGGK 778
Query: 533 IPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLAC 592
I +RW ESI ++T SDVW+YG+ +WE+ S+ +PY+ M++E V L+D L
Sbjct: 779 IALRWTAPESIRCRQFTSASDVWSYGIVMWEVMSYGEKPYWDMSNEVVTEVLEDGYRLPS 838
Query: 593 PDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
P+ P V+ LM +CW++ P RP I +TLD+
Sbjct: 839 PEGCPTPVHSLMLKCWSYEPKRRPTLLEIIKTLDH 873
>UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep:
Ephrin receptor - Mus musculus (Mouse)
Length = 819
Score = 172 bits (418), Expect = 3e-41
Identities = 98/279 (35%), Positives = 150/279 (53%), Gaps = 25/279 (8%)
Query: 353 RDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNI 412
R +G G FG V + +P + VA+K LK + + DF EA ++ FDHPNI
Sbjct: 495 RVIGAGEFGEVCSGRLK--LPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNI 552
Query: 413 VKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXX 472
+ L GV +P+ ++ EYM G L+ +L+ F ++
Sbjct: 553 IHLEGVVTKSKPVMIVTEYMENGSLDTFLK--KNDGQFTVIQ----------------LV 594
Query: 473 XIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKG---DE 529
+ R IA+GM YLSD +VHRDLA RN LIN ++V K++DFGLS L+D +
Sbjct: 595 GMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSR--VLEDDPEAAYTTR 652
Query: 530 HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV 589
IP+RW E+I + K+T SDVW+YG+ +WE+ S+ +PY+ MT+++V++ +++
Sbjct: 653 GGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYR 712
Query: 590 LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L P + P +Y LM CW + + RP F I LD +
Sbjct: 713 LPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNMLDKL 751
>UniRef50_Q4SFK0 Cluster: Chromosome 7 SCAF14601, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 7
SCAF14601, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 993
Score = 171 bits (417), Expect = 4e-41
Identities = 99/289 (34%), Positives = 149/289 (51%), Gaps = 19/289 (6%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V + + IP ++ V +K LK + + DF EA ++ F HPNI+
Sbjct: 605 IGAGEFGEVCRGRLK--IPGKKENYVPIKTLKGGYTDKQRRDFLSEASIMGQFQHPNIIH 662
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEH----REXXXXXXXXXXXXX 470
L GV P+ +L E+M G L+ +LR +T + A R
Sbjct: 663 LEGVITASCPVMILTEFMENGALDSFLRVSATHKTHAKTRSAGPCRSLTEPFLFPVAERQ 722
Query: 471 ------XXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDY 524
R IASGM YLS+ +VHRDLA RN LIN ++V K++DFGLS +LQ+
Sbjct: 723 PVHPHPARGDVRGIASGMKYLSEMSYVHRDLAARNILINSNLVCKVSDFGLSR--FLQEN 780
Query: 525 -----YKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
Y IP+RW E+I + K+T SDVW+YG+ +WE+ SF +PY+ M++++
Sbjct: 781 SSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQD 840
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
V+ ++ + L P + P ++ LM CW + S RP F + LD +
Sbjct: 841 VINAIEQDYRLPPPPDCPTHLHQLMLDCWQKDRSARPRFADLVSALDKL 889
>UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56;
n=15; Sophophora|Rep: Focal adhesion kinase homolog
DFak56 - Drosophila melanogaster (Fruit fly)
Length = 1200
Score = 171 bits (417), Expect = 4e-41
Identities = 88/249 (35%), Positives = 137/249 (55%), Gaps = 19/249 (7%)
Query: 380 VAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNE 439
VA+K K + +F EA ++ FDHP+I++L+G+C++ P+ ++ E G+L
Sbjct: 510 VAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSV-MPIWIVMELAKLGELRA 568
Query: 440 YLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRN 499
YL+ S S + Q+++ + YL +KFVHRD+A RN
Sbjct: 569 YLKTNSERLSHGTL------------------LKYCYQLSTALSYLESKKFVHRDIAARN 610
Query: 500 CLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGV 559
L++ VK+ADFGLS + Q YY A+P++WM ESI + ++T SDVW +GV
Sbjct: 611 VLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGV 670
Query: 560 CLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
C+WEI ++P+ G+ + +V+ L++ L P N P +Y LM QCW + P RPNF+
Sbjct: 671 CIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFK 730
Query: 620 VIYQTLDNI 628
I +TL I
Sbjct: 731 RIKETLHEI 739
>UniRef50_Q9GRH1 Cluster: Tyrosine-protein kinase receptor; n=4;
Porifera|Rep: Tyrosine-protein kinase receptor - Sycon
raphanus
Length = 614
Score = 171 bits (417), Expect = 4e-41
Identities = 95/289 (32%), Positives = 150/289 (51%), Gaps = 7/289 (2%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E +++ ++++G+GAFG+V++ I D + T VA+K L + + F EA
Sbjct: 237 ELVPDSLTMVKEVGEGAFGKVYEGVL-ATIEDGDLT-VAIKTLSTCENVAQRNAFLGEAS 294
Query: 403 LLADFDHPNIVKLLG-VCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
++ FD P +++L G V + +P+ ++ E+M +GDL YL C
Sbjct: 295 IMKKFDCPYVMRLFGLVSTVNKPLVVM-EFMAEGDLRGYLMKCRPQEEQFATRFSGSSQS 353
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL 521
A Q+A GM ++ ++ FVHRDLA RNC+I ++V+KI DFG + IY
Sbjct: 354 TSKAPSVDQFKLWALQLAKGMAHVHEKHFVHRDLAARNCMIATNLVLKIGDFGFTRDIYE 413
Query: 522 QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
DYY+ +PVRWM E + Y ESDVW+YG+ LWE+ + G +HEEV+
Sbjct: 414 SDYYRKTGGGVLPVRWMGPECLRDGLYIPESDVWSYGIVLWEMATLRGPAIPGESHEEVM 473
Query: 582 RFLKDENVLACP---DNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
+ + P + P D+M++CW P+DRP F I + LD+
Sbjct: 474 NMVIGSGHMERPTVLHDFPSQCMDIMERCWQFQPADRPTFADIVRVLDD 522
>UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000020257 - Anopheles gambiae
str. PEST
Length = 1192
Score = 171 bits (417), Expect = 4e-41
Identities = 95/291 (32%), Positives = 155/291 (53%), Gaps = 24/291 (8%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
E+ E +++I + +G+G FG V++AK + + TLVAVK + + + F +
Sbjct: 922 ERWELSNDDVILLDKIGRGNFGDVYKAK----LKSSKNTLVAVKTCRMTLPEEQKRKFLQ 977
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
E +L +DHPNIVKL+G+C +P+ ++ E + G L +LR ++ R+
Sbjct: 978 EGRILKQYDHPNIVKLIGICVQKQPIMIVMELVAGGSLLMFLRKNASTLG-----QRQMM 1032
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ R A+GM YL + +HRDLA RNCLI + +VKI+DFG+S +
Sbjct: 1033 G-------------MCRDAAAGMRYLESKNCIHRDLAARNCLIGSENIVKISDFGMSREE 1079
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
++Y IP++W E++ + KYT DVW+YG+ +WEIFS PY GM++
Sbjct: 1080 --EEYIVSGGMKQIPIKWTAPEALNFGKYTSLCDVWSYGILVWEIFSRGDTPYSGMSNSM 1137
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQL 630
+ + + P+ P +Y LM +CW++ P RP+F I +D + L
Sbjct: 1138 ARERIDEGYRMPAPEGAPPEMYRLMLKCWSYEPESRPHFDEICSVVDALLL 1188
>UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=51;
Euteleostomi|Rep: Ephrin type-A receptor 7 precursor -
Homo sapiens (Human)
Length = 998
Score = 171 bits (416), Expect = 5e-41
Identities = 96/277 (34%), Positives = 149/277 (53%), Gaps = 21/277 (7%)
Query: 353 RDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNI 412
R +G G FG V + +P + VA+K LK + + DF EA ++ FDHPN+
Sbjct: 637 RVIGAGEFGEVCSGRLK--LPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNV 694
Query: 413 VKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXX 472
V L GV G+P+ ++ E+M G L+ +LR F ++
Sbjct: 695 VHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDG--QFTVIQ----------------LV 736
Query: 473 XIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ-DYYKGDEHD 531
+ R IA+GM YL+D +VHRDLA RN L+N ++V K++DFGLS I +
Sbjct: 737 GMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGG 796
Query: 532 AIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLA 591
IPVRW E+I Y K+T SDVW+YG+ +WE+ S+ +PY+ M++++V++ +++ L
Sbjct: 797 KIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP 856
Query: 592 CPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P + P ++ LM CW ++RP F I LD +
Sbjct: 857 APMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKM 893
>UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=1; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 986
Score = 171 bits (415), Expect = 6e-41
Identities = 96/279 (34%), Positives = 147/279 (52%), Gaps = 30/279 (10%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V +P + VA+K LK + + DF EA ++ FDHPN++
Sbjct: 648 IGAGEFGEVCSGNLK--LPGKREMFVAIKTLKTGYTEKQRRDFLSEASIMGQFDHPNVIH 705
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV P+ ++ E+M G L+ +LR H + +
Sbjct: 706 LEGVVTKSSPVMIITEFMENGSLDAFLRVSI---------HGDQLVG------------M 744
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQD-----YYKGDE 529
R IASGM YL+D +VHRDLA RN L+N ++V K++DFGLS +L+D Y
Sbjct: 745 LRGIASGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSR--FLEDDTSDPTYTSAL 802
Query: 530 HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV 589
IP+RW E+I Y K+T SDVW+YG+ +WE+ S+ +PY+ MT+++V+ ++ +
Sbjct: 803 GGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYR 862
Query: 590 LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L P + P ++ LM CW + ++RP F I LD +
Sbjct: 863 LPPPMDCPSTLHQLMLDCWQKDRNNRPKFSQIVNNLDKM 901
>UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=5; Euteleostomi|Rep: Chromosome 11
SCAF14979, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1042
Score = 171 bits (415), Expect = 6e-41
Identities = 100/277 (36%), Positives = 146/277 (52%), Gaps = 25/277 (9%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG VF+ E VA+K LK S +LDF EA ++ F HPNI+
Sbjct: 688 IGVGEFGEVFRGVMKTRGQGE--VNVAIKTLKPGYSEKQRLDFLSEASIMGQFSHPNIIH 745
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV + + ++ EYM G L+ YL+ P + +
Sbjct: 746 LEGVVTKFKHIMIVTEYMDNGALDTYLKGRDG--EIPPYQ----------------LVGM 787
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGD---EHD 531
R IA+GM YLS+ +VHRDLA RN L+N ++ K++DFGLS L+D +G
Sbjct: 788 LRGIAAGMQYLSNMSYVHRDLAARNILVNSNLECKVSDFGLSR--VLEDDDEGTYTTRGG 845
Query: 532 AIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLA 591
IP+RW E+I Y K+T SDVW++G+ +WE+ +F +PY+ M++ EV++ + + L
Sbjct: 846 KIPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINEAFRLP 905
Query: 592 CPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P + P +Y LM QCW H+ S RP F I LD +
Sbjct: 906 APMDCPSAIYQLMLQCWQHDRSKRPRFSDIVSFLDKL 942
>UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 780
Score = 170 bits (413), Expect = 1e-40
Identities = 93/275 (33%), Positives = 148/275 (53%), Gaps = 21/275 (7%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V + +P + VA+K LK + + DF EA ++A FDHPN+++
Sbjct: 421 IGSGEFGEVCYGRMR--LPGKRDIPVALKTLKVGYTEKQKRDFLAEASIMAQFDHPNVIR 478
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV +P+ ++ EYM G L+ +LR F ++ +
Sbjct: 479 LEGVVTHSKPVMIITEYMENGSLDSFLRRHDG--QFTIIQ----------------LVGL 520
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ-DYYKGDEHDAI 533
R IA+GM YLSD ++HRDLA RN L+N ++V K++DFGLS + D I
Sbjct: 521 LRGIAAGMTYLSDLGYIHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTSGGKI 580
Query: 534 PVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACP 593
P+RW E+I + K++ SDVW+YGV +WE+ S+ +PY+ +T+ +V++ +++ L P
Sbjct: 581 PIRWTAPEAITFRKFSSSSDVWSYGVVMWEVTSYGERPYWNLTNRDVIKSVEEGYRLPAP 640
Query: 594 DNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P ++ LM CW + ++RP F I LD +
Sbjct: 641 MGCPAALHTLMLDCWQKDRNERPRFCQIVTVLDKL 675
>UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 865
Score = 170 bits (413), Expect = 1e-40
Identities = 100/277 (36%), Positives = 146/277 (52%), Gaps = 17/277 (6%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTL--VAVKMLKDEASHDLQLDFEREACLLADFDHPNI 412
+G+GAFG+V++ GL+ E ++ VA+K +K A + F E + F HPNI
Sbjct: 595 IGEGAFGKVYK----GLLTQAESSVEHVAIKTIKIFAGIESIRSFFTECASMTSFRHPNI 650
Query: 413 VKLLGVC---AIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXX 469
++L G+C G P+ +L +M G+L YL V S P+ E
Sbjct: 651 IELFGMCFDAPDGTPLMVL-PFMINGNLKSYL-----VKSRNPLS--EKPDIFPNELGLA 702
Query: 470 XXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDE 529
+ IA GM Y D++FVHRDLA RNCL++ D+ VKI DFGL+ +Y+ YYK
Sbjct: 703 VMTKMCTDIARGMSYFVDQRFVHRDLAARNCLLDHDLTVKIGDFGLARNVYMTGYYKAST 762
Query: 530 HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV 589
A+PV+WM E + ++DVWAYGV WE+FS PY G+ + V+ L
Sbjct: 763 RAALPVKWMAPEMLRDGISNEKTDVWAYGVTCWEVFSLGSTPYPGVDNHLVLEHLMKGFR 822
Query: 590 LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
LA P Y ++++CW++NP DRP F I ++
Sbjct: 823 LAKPFLCFEKNYQILQRCWSNNPGDRPCFSQILNEME 859
>UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Rep:
Tyrosine kinase - Sycon raphanus
Length = 879
Score = 170 bits (413), Expect = 1e-40
Identities = 99/289 (34%), Positives = 148/289 (51%), Gaps = 23/289 (7%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLD 396
P L + +NI+ +G+G FG VF+ G + VAVK + E D Q
Sbjct: 608 PDLREYNISHDNILIGEKIGKGNFGDVFK----GYLKTHNME-VAVKSCRSEDFPDKQ-K 661
Query: 397 FEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
F +EA +L + HPNIV+L+GVCA P+ ++ E M G+ +LR P R
Sbjct: 662 FLQEAEILKQYRHPNIVELIGVCAEKEPLYIIMELMAGGNFLSFLRG--------PEGKR 713
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
+ + A+GM++L R +HRDLA RNCL+ D+ V+KI+DFG+S
Sbjct: 714 ---------LKVNNLTEMCVEAAAGMVFLEQRNCIHRDLAARNCLVGDNNVLKISDFGMS 764
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
+ Y IP++W E++ Y +YT +SDVW+YG+ LWE +++ PY GM
Sbjct: 765 REEDDGIYTVSSGLKQIPIKWTSPEALNYGRYTTQSDVWSYGILLWETYTYGSGPYPGMN 824
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+ E ++ + P+ P VY LM CW ++P RP+F IY L
Sbjct: 825 NRETRERIESNYRMPRPELCPHPVYKLMLSCWEYDPDKRPSFAEIYDKL 873
>UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12;
Eumetazoa|Rep: Tyrosine-protein kinase Fps85D -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 170 bits (413), Expect = 1e-40
Identities = 99/294 (33%), Positives = 151/294 (51%), Gaps = 25/294 (8%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
E+ E ++++ + +G+G FG V++AK D VAVK + + + F +
Sbjct: 1054 ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-----VAVKTCRMTLPDEQKRKFLQ 1108
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
E +L +DHPNIVKL+G+C +P+ ++ E + G L YLR S
Sbjct: 1109 EGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN------------- 1155
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+ R A+GM YL + +HRDLA RNCL++ + VKI+DFG+S +
Sbjct: 1156 -----GLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREE 1210
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
++Y D IPV+W E++ + KYT DVW+YG+ +WEIFS PY GMT+
Sbjct: 1211 --EEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSR 1268
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILE 633
+ + P +TP +Y LM QCW + RP+F IY +D + L L+
Sbjct: 1269 ARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLD 1322
>UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=103;
Euteleostomi|Rep: Ephrin type-A receptor 5 precursor -
Homo sapiens (Human)
Length = 1037
Score = 170 bits (413), Expect = 1e-40
Identities = 97/279 (34%), Positives = 149/279 (53%), Gaps = 25/279 (8%)
Query: 353 RDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNI 412
R +G G FG V + +P + VA+K LK + + DF EA ++ FDHPNI
Sbjct: 679 RVIGAGEFGEVCSGRLK--LPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNI 736
Query: 413 VKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXX 472
+ L GV +P+ ++ EYM G L+ +L+ F ++
Sbjct: 737 IHLEGVVTKSKPVMIVTEYMENGSLDTFLK--KNDGQFTVIQ----------------LV 778
Query: 473 XIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKG---DE 529
+ R I++GM YLSD +VHRDLA RN LIN ++V K++DFGLS L+D +
Sbjct: 779 GMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSR--VLEDDPEAAYTTR 836
Query: 530 HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV 589
IP+RW E+I + K+T SDVW+YG+ +WE+ S+ +PY+ MT+++V++ +++
Sbjct: 837 GGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYR 896
Query: 590 LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L P + P +Y LM CW + RP F I LD +
Sbjct: 897 LPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKL 935
>UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1;
n=11; Metazoa|Rep: Tyrosine-protein kinase isoform SRK1
- Spongilla lacustris (Freshwater sponge)
Length = 505
Score = 169 bits (412), Expect = 1e-40
Identities = 96/296 (32%), Positives = 155/296 (52%), Gaps = 27/296 (9%)
Query: 331 TGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEAS 390
T L E+ E + I +R LG G FG V++ G T VAVK LK +
Sbjct: 222 TAGLLRQANEEWEIEKTQIKLLRRLGAGQFGEVWEGLWNGT------TSVAVKTLKP-GT 274
Query: 391 HDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSF 450
++ +F +EA ++ HP +++L VC P+ ++ E M G L EYLR V
Sbjct: 275 MSVE-EFLQEASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKI 333
Query: 451 APVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKI 510
+ +A Q+ASGM YL + ++HRDLA RN L+ + + K+
Sbjct: 334 EQL------------------VDVAAQVASGMSYLEQQNYIHRDLAARNILVGEHGICKV 375
Query: 511 ADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQ 570
ADFGL+ ++ ++ Y+ P++W E+ +YN++T++SDVW++GV L+EI ++
Sbjct: 376 ADFGLA-RVIDEEIYEAHTGAKFPIKWTAPEAAMYNRFTIKSDVWSFGVVLYEIITYGRF 434
Query: 571 PYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
PY GMT+ EV+ ++ + CP N P+ +D+M CW +P+ RP F + L+
Sbjct: 435 PYPGMTNPEVLEKIQQNYRMPCPANCPKQFHDIMLDCWREDPASRPTFETLQWQLE 490
>UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whole
genome shotgun sequence; n=3; Tetraodontidae|Rep:
Chromosome undetermined SCAF14659, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 712
Score = 169 bits (411), Expect = 2e-40
Identities = 100/278 (35%), Positives = 149/278 (53%), Gaps = 27/278 (9%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V++ +P + + VA+K LK + + DF EA ++ F H NI++
Sbjct: 358 IGAGEFGEVYRGILK--VPGRKESAVAIKTLKPGYTEKQRQDFLSEASIMGQFAHQNIIR 415
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACS-TVTSFAPVEHREXXXXXXXXXXXXXXXX 473
L GV + ++ EYM G L+ YLR TSF V
Sbjct: 416 LEGVVTKFKHAMIITEYMENGALDRYLRDHDGEFTSFQLV-------------------G 456
Query: 474 IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDA- 532
+ R IA+GM YLSD +VHRDLA RN L+N+ + K++DFGLS L+D +G +
Sbjct: 457 MLRGIAAGMKYLSDMSYVHRDLAARNILVNNTLECKVSDFGLSR--VLEDDPEGTYTTSG 514
Query: 533 --IPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
IP+RW E+I Y K+ SDVW++G+ +WE+ +F +PY+ M++ EV++ + + L
Sbjct: 515 GKIPIRWTAPEAIAYRKFASASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINEAFRL 574
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P + P VY LM QCW H+ + RP F I LD +
Sbjct: 575 PAPMDCPSAVYQLMLQCWLHDRAKRPRFGDIVNLLDKL 612
>UniRef50_Q9Y1X7 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 385
Score = 169 bits (411), Expect = 2e-40
Identities = 92/284 (32%), Positives = 149/284 (52%), Gaps = 6/284 (2%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
+ PR +++ LG G +G V++A++ L + +V VKML ++AS ++ FE++
Sbjct: 99 QHPRGDLVLEEKLGDGEYGPVYRAQSYNLPGKKGSRVVTVKMLLEDASEAHRIAFEKDIA 158
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
LL F+H N++ +L VC P C+L + G L +LR + +
Sbjct: 159 LLNSFNHVNVMGVLAVCTGESPQCILLDAGLPGSLLTHLREAKRLAR----QKIPAKQLL 214
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ 522
+A + GM YLS + FV +DLA RNC++ D VK+ADFG+ ++ +
Sbjct: 215 VDMTSPASLLHMADDVCLGMAYLSSQAFVVKDLAARNCIVGADGRVKVADFGVGPSVFPE 274
Query: 523 DYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVR 582
Y + P+RWM ESI +Y+ SD+WA+GV +WE+F+ PY M+ +EVVR
Sbjct: 275 AYCTLHGRPS-PLRWMAAESIESGQYSTASDIWAFGVFIWELFTGGDLPYTEMSDDEVVR 333
Query: 583 FL-KDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
++ K+ L P+N P VY +M CW + R F +++ L
Sbjct: 334 YVTKECGKLQMPENCPSDVYTIMLSCWENEAKSRQLFLTLHEHL 377
>UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to
protein-tyrosine kinase; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to protein-tyrosine
kinase - Strongylocentrotus purpuratus
Length = 837
Score = 169 bits (410), Expect = 3e-40
Identities = 101/266 (37%), Positives = 144/266 (54%), Gaps = 25/266 (9%)
Query: 354 DLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIV 413
++GQG FG V + K + + VA+K L + Q +F REA ++ DHP IV
Sbjct: 568 EIGQGEFGSVLEGKYK---EKDRWVKVALKTLHADHLQTGQKEFLREAKVMCGLDHPCIV 624
Query: 414 KLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXX 473
KL+GVC +G PM L+ E + +G L ++L+ S S +
Sbjct: 625 KLMGVC-LGPPMMLVQELVSQGALLDFLQNDSITASDLKLW------------------- 664
Query: 474 IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ-DYYKGDEHDA 532
A QIASGM+YL +KFVHRDLA RN L+ + KI+DFGLS DYY+
Sbjct: 665 -ATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGR 723
Query: 533 IPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLAC 592
PV+W ESI Y ++ SDVW +GV LWE+ S QPY T EV++ +++ + L
Sbjct: 724 WPVKWYAPESIYYGTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIENGHRLNR 783
Query: 593 PDNTPRCVYDLMKQCWNHNPSDRPNF 618
P+ P+ VY +M +CW++ P +RP F
Sbjct: 784 PEGCPQNVYQIMNKCWSYKPCNRPTF 809
>UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;
n=6; Bilateria|Rep: Developmental receptor tyrosine
kinase - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 874
Score = 168 bits (409), Expect = 3e-40
Identities = 103/302 (34%), Positives = 156/302 (51%), Gaps = 24/302 (7%)
Query: 333 AQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHD 392
+ L KL+ + + R LG+G FG V +A + VAVK+LK + +
Sbjct: 481 SDLKAKLQDVLIFERLLTLGRMLGKGEFGSVREAFLKS--ENNSGQKVAVKVLKTDINSS 538
Query: 393 LQLD-FEREACLLADFDHPNIVKLLGVCAIGR-------PMCLLFEYMGKGDLNEYLRAC 444
++ +EA + DF HPN+++L+GV R PM +L +M GDL+ +L
Sbjct: 539 SDIEQCLKEAAYMKDFHHPNVIQLIGVSLHRRAQQRLPIPMVIL-PFMKHGDLHTFLLMS 597
Query: 445 STVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIND 504
V + IA GM YLS++ +HRDLA RNC++N+
Sbjct: 598 RLGDEPFTVSQQ-------------ILIQFMLDIARGMEYLSNKNIIHRDLAARNCMLNE 644
Query: 505 DMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEI 564
+M V +ADFGLS KIY DYY+ +PV+W+ LES+ N YT +SDVWA+GV +WEI
Sbjct: 645 NMSVCVADFGLSKKIYSGDYYRQGSVSKLPVKWIALESLADNVYTTQSDVWAFGVTMWEI 704
Query: 565 FSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQT 624
+ PY G+ + E+ +L L P + P +Y++M CW+ P RP+F+ +
Sbjct: 705 MTRGQTPYPGVENSEIYEYLIKGERLKQPPDCPADIYEIMHSCWSPVPKCRPSFQHLIDQ 764
Query: 625 LD 626
L+
Sbjct: 765 LE 766
>UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: Eph
receptor - Manduca sexta (Tobacco hawkmoth) (Tobacco
hornworm)
Length = 1011
Score = 168 bits (409), Expect = 3e-40
Identities = 97/275 (35%), Positives = 145/275 (52%), Gaps = 20/275 (7%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V + K +E VA+K LK ++ + DF EA ++ F+HPN++
Sbjct: 653 IGGGEFGDVCRGKLKLASCGQEID-VAIKTLKPGSTERARRDFLAEASIMGQFEHPNVIF 711
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV P+ ++ E+M G L+ +LRA F ++ +
Sbjct: 712 LQGVVTKCNPIMIITEFMENGSLDTFLRANDG--KFMVLQ----------------LVGM 753
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIY-LQDYYKGDEHDAI 533
R IA+GM YLS+ ++HRDLA RN L+N +V KIADFGLS +I D I
Sbjct: 754 LRGIATGMQYLSEMNYIHRDLAARNVLVNSHLVCKIADFGLSREIESTADGAYTTRGGKI 813
Query: 534 PVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACP 593
PVRW E+I + K+T SDVW+ G+ WE+ SF +PY+ ++++V++ ++ L P
Sbjct: 814 PVRWTAPEAIAFRKFTSASDVWSMGIVCWEVMSFGERPYWNWSNQDVIKSIEKGYRLPAP 873
Query: 594 DNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ P VY LM CW + RP F I +TLD +
Sbjct: 874 MDCPEAVYQLMLDCWQKERTHRPTFASIVKTLDKL 908
>UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to
ENSANGP00000019144; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000019144 - Nasonia
vitripennis
Length = 1220
Score = 168 bits (408), Expect = 5e-40
Identities = 100/287 (34%), Positives = 154/287 (53%), Gaps = 10/287 (3%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFT-LVAVKMLKDEASHDLQLDFEREA 401
EFPR+ + LG+G FG+V++A+A L + T LVAVK +K+ AS + D RE
Sbjct: 916 EFPRDKLRLQTVLGEGNFGQVWKAEADDLTGHQGTTRLVAVKTVKEGASDREKEDLVREL 975
Query: 402 CLLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXX 460
++ HPN+V LLG C P L+ EY+ G L YLR T F E
Sbjct: 976 EIMQRVGSHPNVVTLLGCCTEQEPHYLILEYVMYGKLLAYLRDHRTRQDF--YNFSEDSA 1033
Query: 461 XXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIY 520
+AR GM YL+ +K +HRDLA RN L++ + + KIADFG+S
Sbjct: 1034 ALTSRDLTVFGYCVAR----GMEYLASKKIIHRDLAARNVLVDHNKLCKIADFGMSRFAN 1089
Query: 521 LQDYYKGDEH--DAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
H +A+P+RWM ES++Y+ +T ++DVW++G+ +WEI + PY MT
Sbjct: 1090 EDGEVIETRHGRNALPIRWMAPESLIYSLFTTKTDVWSFGILMWEIVTLGSTPYPDMTAR 1149
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
EV+R ++ L P + ++ ++ +CW+ +P RP F+++ + L
Sbjct: 1150 EVMRSVQSGYRLERPSHCRSELFRVIARCWHADPDRRPEFQLLRRDL 1196
>UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1;
Aplysia californica|Rep: Neurite outgrowth regulated
kinase - Aplysia californica (California sea hare)
Length = 991
Score = 168 bits (408), Expect = 5e-40
Identities = 97/291 (33%), Positives = 155/291 (53%), Gaps = 19/291 (6%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADF-DHPNIV 413
LGQGAFG+V G D++ VA+K++++ A + D E L+ HPNIV
Sbjct: 592 LGQGAFGKV----VTGYYEDQK---VAIKIVREGAPLSYKEDLVAEINLMKRIGSHPNIV 644
Query: 414 KLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSF-----APVEH-----REXXXXXX 463
L+G C + P+ L+ EY+ G+L +L+ C P E ++
Sbjct: 645 CLIGACTMSEPIALVMEYVPYGNLQNFLKKCRMDGDVRKRCDGPSEITYTVIQDNGSMES 704
Query: 464 XXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQD 523
ARQ+A M YL+++K+VHRDLA RN LI+ + VVK+ DFGLS I+ +
Sbjct: 705 GVVTPVDMLSFARQVAMAMEYLAEKKYVHRDLAARNVLIDYNKVVKVCDFGLSRDIFNDN 764
Query: 524 YYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRF 583
+YK + +P++WM +ES+ +T +SDVW++G+ LWEI + PY + ++
Sbjct: 765 HYKKLTNGKLPLKWMAIESLRDRMFTTQSDVWSFGILLWEIVTMGASPYPNVALADLYYV 824
Query: 584 LKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILER 634
L + + P N + +Y +M+ CW +DRPNF + L+++ LI +R
Sbjct: 825 LSNGYRMDRPSNCSQELYAIMRACWEDESTDRPNFTQLRLMLEDL-LIEDR 874
>UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Src tyrosine kinase - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 168 bits (408), Expect = 5e-40
Identities = 103/299 (34%), Positives = 156/299 (52%), Gaps = 27/299 (9%)
Query: 329 HTTGAQLNPKL-EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKD 387
H L+ KL +K E P+++II +GQG FG VF+A + T+VAVK LK
Sbjct: 325 HPEPVGLSHKLIDKWEIPKSSIILKEKIGQGQFGEVFKAVW------NKTTIVAVKTLKP 378
Query: 388 EASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTV 447
+ DF REA + HPN+++L VC P ++ EYM KG L YL++
Sbjct: 379 SSCD--AADFLREAQTMKRLHHPNLIQLYAVCTQTEPFYIVTEYMSKGSLLNYLQSPE-- 434
Query: 448 TSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMV 507
+A +IA GM YL R+ +HRDLA RN L+ +
Sbjct: 435 ---------------GNALNMQCLIMMAAKIAPGMAYLESRRHIHRDLAARNVLVGEQHA 479
Query: 508 VKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSF 567
VKIADFGL+ I+ ++Y P++W E+ Y+++T++SDVW++G+ L EI ++
Sbjct: 480 VKIADFGLARMIHNREYV-AHAGARFPIKWTSPEAANYSRFTIKSDVWSFGILLTEIVTY 538
Query: 568 ALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
PY GM + EV+R + ++ P P +YDLM +CW + + RP+F I+ L+
Sbjct: 539 GRSPYPGMHNAEVLRQVDAGYRMSKPPGCPPELYDLMLECWAADENKRPSFATIHFRLE 597
>UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111;
Euteleostomi|Rep: Focal adhesion kinase 1 - Homo sapiens
(Human)
Length = 1052
Score = 168 bits (408), Expect = 5e-40
Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 22/292 (7%)
Query: 337 PKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLD 396
P E R I R +G+G FG V Q + P+ VA+K K+ S ++
Sbjct: 410 PSTRDYEIQRERIELGRCIGEGQFGDVHQGIY--MSPENPALAVAIKTCKNCTSDSVREK 467
Query: 397 FEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
F +EA + FDHP+IVKL+GV P+ ++ E G+L +L+ A +
Sbjct: 468 FLQEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASL--- 523
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
A Q+++ + YL ++FVHRD+A RN L++ + VK+ DFGLS
Sbjct: 524 ---------------ILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLS 568
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
+ YYK + +P++WM ESI + ++T SDVW +GVC+WEI ++P+ G+
Sbjct: 569 RYMEDSTYYKASK-GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVK 627
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ +V+ +++ L P N P +Y LM +CW ++PS RP F + L I
Sbjct: 628 NNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI 679
>UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2)
(EPH homology kinase 2).; n=2; Xenopus tropicalis|Rep:
Ephrin type-A receptor 6 precursor (EC 2.7.10.1)
(Tyrosine-protein kinase receptor EHK-2) (EPH homology
kinase 2). - Xenopus tropicalis
Length = 952
Score = 167 bits (407), Expect = 6e-40
Identities = 105/315 (33%), Positives = 162/315 (51%), Gaps = 31/315 (9%)
Query: 315 MDIDLDKLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPD 374
+D D + PS LA H +++P ++E R +G G FG V + P
Sbjct: 564 IDPDTYEDPS-LAVHEFAKEIDPSRIRIE---------RVIGAGEFGEVCSGRLK--TPA 611
Query: 375 EEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGK 434
++ VA+K LK + DF REA ++ FDHPNI++L GV RP+ ++ EYM
Sbjct: 612 KKEIPVAIKTLKGGYVDRQRKDFLREASIMGQFDHPNIIRLEGVVTKSRPVMIVVEYMEN 671
Query: 435 GDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRD 494
G L+ +LR F ++ + R IASGM YLSD +VHRD
Sbjct: 672 GSLDSFLRKHDG--QFTVIQ----------------LVGMLRGIASGMKYLSDMGYVHRD 713
Query: 495 LATRNCLINDDMVVKIADFGLSHKIYLQ-DYYKGDEHDAIPVRWMPLESILYNKYTLESD 553
LA RN L+N ++V K++DFGLS + D IP+RW E+I + K++ SD
Sbjct: 714 LAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRKFSSASD 773
Query: 554 VWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPS 613
W+YG+ +WE+ S+ +PY+ M++++V+ +++ L P P ++ LM CW + +
Sbjct: 774 AWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPVSLHQLMLHCWQKDRN 833
Query: 614 DRPNFRVIYQTLDNI 628
RP F I LD +
Sbjct: 834 IRPKFSDIVGFLDKL 848
>UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=2; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 1071
Score = 167 bits (407), Expect = 6e-40
Identities = 95/279 (34%), Positives = 146/279 (52%), Gaps = 27/279 (9%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V P + LVA+K LK + + DF EA ++ FDHPNI+
Sbjct: 730 IGAGEFGEVCSGNLRQ--PGKREILVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIH 787
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV P+ ++ E+M G L+ +LR F ++ +
Sbjct: 788 LEGVVTKSSPVMIITEFMENGSLDSFLR--QNDGQFTVIQ----------------LVGM 829
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQD-----YYKGDE 529
R IA+G+ YL D +VHRDLA RN L+N ++V K++DFGLS +L+D Y
Sbjct: 830 LRGIAAGVKYLCDMNYVHRDLAARNILVNSNLVCKVSDFGLSR--FLEDDTSDPTYTSAL 887
Query: 530 HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV 589
IP+RW E+I Y K+T SD W+YG+ +WE+ S+ +PY+ M++++V+ ++ +
Sbjct: 888 GGKIPIRWTAPEAIQYRKFTSSSDCWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYR 947
Query: 590 LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L P + P ++ LM CW ++RP F I TLD +
Sbjct: 948 LPPPMDCPSALHQLMLDCWQKERNNRPKFSQIVSTLDKM 986
>UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like
protein; n=1; Tribolium castaneum|Rep: Receptor tyrosine
kinase Torso-like protein - Tribolium castaneum (Red
flour beetle)
Length = 803
Score = 167 bits (407), Expect = 6e-40
Identities = 120/372 (32%), Positives = 180/372 (48%), Gaps = 29/372 (7%)
Query: 283 VLAIAG-IALLCHYIVKNHYS-KCNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQLNPKL- 339
VL IA IA L + N+Y K R +D +KLP + + + P +
Sbjct: 383 VLIIAPLIATLIATVTVNYYRHKQKRRDERERYFKGLDEEKLPES-GENIEINLIKPDIF 441
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
++ E + + +G+GAFG V +A + ++ T VAVKMLK+ + + F +
Sbjct: 442 DQWELGPLKLSFQGVIGEGAFGIVRRAFLD--LKEDNKTQVAVKMLKESPTSEEIRQFTQ 499
Query: 400 EACLLADF-DHPNIVKLLGVCAIGRPM--CLLFEYMGKGDLNEYLRAC-----STVTSFA 451
E ++ HP IV L+G GR L+ EY +GDL YLR + FA
Sbjct: 500 EINIMKSVRQHPYIVSLIGCVTEGRAEGPLLVVEYCSRGDLQTYLRTAWDKFTNMQQQFA 559
Query: 452 PVEHREXXXXXXXXXXXXXXX---------------XIARQIASGMLYLSDRKFVHRDLA 496
++ IARQ+A GM +L+ + VHRDLA
Sbjct: 560 YIDESSNSSNYFANKTYDFHNMSFENDFIIQPKHLLSIARQVALGMEHLAKTRVVHRDLA 619
Query: 497 TRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWA 556
RN L+ ++ VK++DFGLS +Y + Y + +PVRWM LES+ + +YT SDVW+
Sbjct: 620 ARNVLVCENHTVKVSDFGLSRDVYQDNVYCKNGGGKLPVRWMALESLTHQRYTTYSDVWS 679
Query: 557 YGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRP 616
+GV LWEI + PY G+ E++ FLK N LA P N +Y +M CW P +RP
Sbjct: 680 FGVLLWEIVTLGGTPYVGVHSSELLDFLKSGNRLARPANCSPDLYAVMLNCWKECPKNRP 739
Query: 617 NFRVIYQTLDNI 628
F + ++L+ +
Sbjct: 740 TFTELSKSLEGL 751
>UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Ephrin
receptor - Apis mellifera (Honeybee)
Length = 996
Score = 167 bits (406), Expect = 8e-40
Identities = 98/277 (35%), Positives = 148/277 (53%), Gaps = 23/277 (8%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTL-VAVKMLKDEASHDLQLDFEREACLLADFDHPNIV 413
+G G FG V + K L PD + VA+K LK ++ + DF EA ++ F+HPN++
Sbjct: 639 IGGGEFGDVCRGKLK-LPPDGRTEIDVAIKTLKPGSADKARNDFLTEASIMGQFEHPNVI 697
Query: 414 KLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXX 473
L GV P+ ++ E+M G L+ +LRA F ++
Sbjct: 698 FLQGVVTKSNPVMIITEFMENGSLDTFLRANDG--KFQVLQ----------------LVG 739
Query: 474 IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIY--LQDYYKGDEHD 531
+ R IASGM YL++ +VHRDLA RN L+N +V KIADFGLS +I + Y
Sbjct: 740 MLRGIASGMQYLAEMNYVHRDLAARNVLVNAALVCKIADFGLSREIESATEGAYT-TRGG 798
Query: 532 AIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLA 591
IPVRW E+I + K+T SDVW+ G+ WE+ S+ +PY+ ++++V++ ++ L
Sbjct: 799 KIPVRWTAPEAIAFRKFTSASDVWSMGIVCWEVMSYGERPYWNWSNQDVIKSIEKGYRLP 858
Query: 592 CPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P + P +Y LM CW + RP F + QTLD +
Sbjct: 859 APMDCPEAIYQLMLDCWQKERTHRPTFANLTQTLDKL 895
>UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -
Caenorhabditis elegans
Length = 533
Score = 167 bits (405), Expect = 1e-39
Identities = 100/290 (34%), Positives = 148/290 (51%), Gaps = 31/290 (10%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E PRN + R LG G FG V+ K G++ VA+K +K F +EA
Sbjct: 256 EIPRNQLHLKRKLGDGNFGEVWYGKWRGIVE------VAIKTMKPGTMSPEA--FLQEAQ 307
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
++ DHPN+VKL VC P ++ EYM G L +YLR + +
Sbjct: 308 IMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQAL--------- 358
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDM----VVKIADFGLSHK 518
+A QIA+GM+YL +RK VHRDLA RN L+ D + VVK+ADFGL+ K
Sbjct: 359 ---------VDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARK 409
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
+ +D Y+ P++W E+ +T++SDVW+YG+ L+EI + PY GM +
Sbjct: 410 LMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNR 469
Query: 579 EVVRFLKDENVLACPDNTPRCVY-DLMKQCWNHNPSDRPNFRVIYQTLDN 627
EVV ++ + P P +Y +++ +CW+ P RP F +Y D+
Sbjct: 470 EVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDD 519
>UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 315
Score = 167 bits (405), Expect = 1e-39
Identities = 99/296 (33%), Positives = 146/296 (49%), Gaps = 11/296 (3%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
E E P N+ I+ LG G FG V +A A G+ VAVK LK A + DF
Sbjct: 19 EAWEVPPQNLSVIKRLGSGNFGHVDKAMAIGIPGFPGQVTVAVKTLKATAQEKDKTDFLT 78
Query: 400 EACLLADF-DHPNIVKLLGVCA-----IGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPV 453
E L+ HP++V+L+G C + + ++FEY+ GDL YLR +
Sbjct: 79 ELNLMKSLRPHPHVVRLIGCCTRQAGELSNHLAIIFEYLPYGDLLGYLRRSRGHEDW--- 135
Query: 454 EHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADF 513
+ A IA GM +L+ K VHRDLA RN L+ + KI+D
Sbjct: 136 -YCSGDLRPPSRLVSKDLVKFAWMIADGMAFLAANKCVHRDLAARNVLVGEHNTCKISDL 194
Query: 514 GLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYF 573
GL+ + QD Y +PV+WMP ES+LY + + SDVW+YG+ LWEIF+ PY
Sbjct: 195 GLARDVS-QDIYTRTSSARLPVKWMPPESLLYGQSSSASDVWSYGIVLWEIFTIGDSPYP 253
Query: 574 GMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQ 629
G+ + + R L++ + P + +Y +M +CW +P +RP F + + +Q
Sbjct: 254 GVKSKGIPRMLREGYRMPKPPHVGDALYFVMLRCWQEDPDERPTFDELCDNMQALQ 309
>UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|Rep:
Tyrosine kinase receptor - Xenopus laevis (African clawed
frog)
Length = 1369
Score = 166 bits (404), Expect = 1e-39
Identities = 95/280 (33%), Positives = 148/280 (52%), Gaps = 25/280 (8%)
Query: 353 RDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNI 412
R +G+G FG V+ + D++ AVK L + +F RE L+ F HPN+
Sbjct: 1061 RIIGKGHFGSVYHGTY--VDEDQQEVHCAVKSLNRITDLEEVEEFLREGILMKSFHHPNV 1118
Query: 413 VKLLGVCAI--GRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXX 470
+ L+G+C G P+ +L +M GDL ++R+ E R
Sbjct: 1119 LSLIGICLPQEGLPLVVL-PFMKHGDLRHFIRS----------EERNPTVKDLVG----- 1162
Query: 471 XXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEH 530
Q++ GM YL++RKFVHRDLA RNC++++ VK+ADFGL+ ++ ++YY H
Sbjct: 1163 ---FGLQVSRGMEYLANRKFVHRDLAARNCMLDESFHVKVADFGLARDVFDKEYYSVRRH 1219
Query: 531 D--AIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDEN 588
+PV+WM +ES+ K+T +SDVW++GV LWE+ + PY + ++ R+L
Sbjct: 1220 KNARLPVKWMAMESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVDAYDITRYLFRGR 1279
Query: 589 VLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
LA P+ P +Y LM CWN P +RP F + ++ I
Sbjct: 1280 RLAQPEYCPNPLYSLMLSCWNPQPVERPTFTQLVSDMELI 1319
>UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n=4;
Caenorhabditis|Rep: Protein kinase protein 32, isoform a
- Caenorhabditis elegans
Length = 867
Score = 166 bits (404), Expect = 1e-39
Identities = 95/287 (33%), Positives = 156/287 (54%), Gaps = 25/287 (8%)
Query: 346 RNNIIYIRDL-GQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASH-DLQLDFEREACL 403
R +I +++L G G FG V++A L DE VAVK+ K +A D QL + E+ L
Sbjct: 363 RRELITLKELIGGGQFGNVYKAVYHDLEKDERIA-VAVKVCKTDAEPADTQLILQ-ESSL 420
Query: 404 LADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXX 463
+ +F H NI++L+GVC + +PM L+ E KG+L EYL+ + P+
Sbjct: 421 MRNFRHSNIIQLIGVC-VDQPMWLVLELAPKGELREYLQQ---EKDWLPLR--------- 467
Query: 464 XXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQD 523
QI ++YL +FVHRD+A RN L+ VK+ADFGLS +
Sbjct: 468 ------ILTLFCSQICDSLVYLHSTRFVHRDIAARNILVCSPQCVKLADFGLSRALDYDA 521
Query: 524 YYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRF 583
Y +P++W+ ES+ Y ++++ SDVW +GVC+WEIFS ++P+ G+T+ +V+
Sbjct: 522 VYTASR-GKLPIKWLAPESVNYRQFSMASDVWMFGVCMWEIFSLGVKPWAGVTNSDVIMH 580
Query: 584 LKDENVLACPDNTPRCVYDLMK-QCWNHNPSDRPNFRVIYQTLDNIQ 629
++ + CP+ P +Y+ ++ + W P RP IY +++++
Sbjct: 581 IEQGSRPPCPEKCPTALYNFIRSKMWAIEPHKRPTVDQIYAIIEDVR 627
>UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47;
Euteleostomi|Rep: Protein tyrosine kinase 2 beta - Homo
sapiens (Human)
Length = 1009
Score = 166 bits (404), Expect = 1e-39
Identities = 96/283 (33%), Positives = 145/283 (51%), Gaps = 22/283 (7%)
Query: 346 RNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLA 405
R +++ R LG+G FG V++ E VAVK K + + D + F EA ++
Sbjct: 422 REDVVLNRILGEGFFGEVYEGVYTN--HKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMK 479
Query: 406 DFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXX 465
+ DHP+IVKL+G+ P ++ E G+L YL +
Sbjct: 480 NLDHPHIVKLIGIIE-EEPTWIIMELYPYGELGHYLERNKNSLKVLTL------------ 526
Query: 466 XXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYY 525
+ QI M YL VHRD+A RN L+ VK+ DFGLS I +DYY
Sbjct: 527 ------VLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYY 580
Query: 526 KGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLK 585
K +P++WM ESI + ++T SDVW + VC+WEI SF QP+F + +++V+ L+
Sbjct: 581 KASV-TRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLE 639
Query: 586 DENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ L PD P +Y LM +CW+++PSDRP F + +L ++
Sbjct: 640 KGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDV 682
>UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54;
Gnathostomata|Rep: Tyrosine-protein kinase BTK - Homo
sapiens (Human)
Length = 659
Score = 166 bits (404), Expect = 1e-39
Identities = 95/284 (33%), Positives = 144/284 (50%), Gaps = 29/284 (10%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEA-SHDLQLDFEREA 401
E ++ ++++LG G FG V K G VA+KM+K+ + S D +F EA
Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRGQYD------VAIKMIKEGSMSED---EFIEEA 446
Query: 402 CLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
++ + H +V+L GVC RP+ ++ EYM G L YLR + HR
Sbjct: 447 KVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLRE---------MRHR----- 492
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL 521
+ + + M YL ++F+HRDLA RNCL+ND VVK++DFGLS + L
Sbjct: 493 ----FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV-L 547
Query: 522 QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
D Y PVRW P E ++Y+K++ +SD+WA+GV +WEI+S PY T+ E
Sbjct: 548 DDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETA 607
Query: 582 RFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
+ L P VY +M CW+ +RP F+++ +
Sbjct: 608 EHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI 651
>UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4;
Caenorhabditis|Rep: Isoform b of Q10656 - Caenorhabditis
elegans
Length = 988
Score = 166 bits (403), Expect = 2e-39
Identities = 100/298 (33%), Positives = 148/298 (49%), Gaps = 16/298 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E R+ + + LG+GAFG V++A +E VAVK LK A +D E
Sbjct: 582 EVERSKLSLVHMLGEGAFGEVWKATYKETENNE--IAVAVKKLKMSAHEKELIDLVSEME 639
Query: 403 LLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
+H N+++L+G C P+ ++ E G+L ++LRA A +E
Sbjct: 640 TFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDY 699
Query: 462 XXXXXXXXXXXX-------------IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVV 508
A Q+A GM +L+ +K +HRDLA RN L+ D V+
Sbjct: 700 LEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVL 759
Query: 509 KIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFA 568
KI+DFGLS ++ DYY+ + +P++WM LE++ N YT+ESDVW+YGV LWEI +
Sbjct: 760 KISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLG 819
Query: 569 LQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
PY + E+ LK+ + P P+ VY LM CW +RP+F+ I LD
Sbjct: 820 GTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLD 877
>UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF10323,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 815
Score = 166 bits (403), Expect = 2e-39
Identities = 94/281 (33%), Positives = 149/281 (53%), Gaps = 21/281 (7%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E ++I R +G G FG V P +P + LVA+K LK + + DF EA
Sbjct: 472 EIHLSSISIERIIGAGEFGEV--CSGPLRLPGKREILVAIKTLKAGYTEQQRRDFLWEAS 529
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
++ F+HPNI++L GV +P+ ++ EYM G L+ +L+ F ++
Sbjct: 530 IMGQFNHPNIIRLEGVVTKSKPVMIITEYMENGSLDTFLK--KNDGQFTVIQ-------- 579
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ 522
+ R IASGM YLSD +VHRDLA RN L++ +V K++DFGLS +
Sbjct: 580 --------LVGMLRGIASGMRYLSDMGYVHRDLAARNILVDGHLVCKVSDFGLSRALEDD 631
Query: 523 -DYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
+ + IP+RW E+I Y K+T SDVW+YGV +WE+ S+ +PY+ M++++V+
Sbjct: 632 PEAAYTTQGGKIPIRWTAPEAIAYRKFTSASDVWSYGVVMWEVMSYGERPYWDMSNQDVI 691
Query: 582 RFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIY 622
+ +++ L P + P +Y LM CW + V++
Sbjct: 692 KAVEENYRLPGPMDCPESLYQLMTDCWQRERTSPAQVSVLW 732
>UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=19;
Mammalia|Rep: Ephrin type-A receptor 1 precursor - Homo
sapiens (Human)
Length = 976
Score = 166 bits (403), Expect = 2e-39
Identities = 91/274 (33%), Positives = 152/274 (55%), Gaps = 20/274 (7%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G+G FG V++ +P ++ VA+K LKD + +F REA ++ F HP+I+
Sbjct: 630 IGEGEFGEVYRGTLR--LPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILH 687
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV +P+ ++ E+M G L+ +LR RE +
Sbjct: 688 LEGVVTKRKPIMIITEFMENGALDAFLR------------EREDQLVPGQLVA------M 729
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIP 534
+ IASGM YLS+ +VHRDLA RN L+N ++ K++DFGL+ + D + IP
Sbjct: 730 LQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIP 789
Query: 535 VRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPD 594
+RW E+I + +T SDVW++G+ +WE+ SF +PY M+++EV++ ++D L P
Sbjct: 790 IRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPV 849
Query: 595 NTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ P +Y+LMK CW ++ + RP+F+ + L+ +
Sbjct: 850 DCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQL 883
>UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15
precursor; n=7; Caenorhabditis elegans|Rep: Myoblast
growth factor receptor egl-15 precursor - Caenorhabditis
elegans
Length = 1040
Score = 166 bits (403), Expect = 2e-39
Identities = 100/298 (33%), Positives = 148/298 (49%), Gaps = 16/298 (5%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E R+ + + LG+GAFG V++A +E VAVK LK A +D E
Sbjct: 634 EVERSKLSLVHMLGEGAFGEVWKATYKETENNE--IAVAVKKLKMSAHEKELIDLVSEME 691
Query: 403 LLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
+H N+++L+G C P+ ++ E G+L ++LRA A +E
Sbjct: 692 TFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDY 751
Query: 462 XXXXXXXXXXXX-------------IARQIASGMLYLSDRKFVHRDLATRNCLINDDMVV 508
A Q+A GM +L+ +K +HRDLA RN L+ D V+
Sbjct: 752 LEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVL 811
Query: 509 KIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFA 568
KI+DFGLS ++ DYY+ + +P++WM LE++ N YT+ESDVW+YGV LWEI +
Sbjct: 812 KISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLG 871
Query: 569 LQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLD 626
PY + E+ LK+ + P P+ VY LM CW +RP+F+ I LD
Sbjct: 872 GTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLD 929
>UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6;
Endopterygota|Rep: Tyrosine-protein kinase Src64B -
Drosophila melanogaster (Fruit fly)
Length = 552
Score = 165 bits (402), Expect = 2e-39
Identities = 105/302 (34%), Positives = 155/302 (51%), Gaps = 29/302 (9%)
Query: 335 LNPKL-EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDL 393
L P+L +K E PR+ I +R LG+G FG VF K I VAVK L++
Sbjct: 269 LGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSID------VAVKTLREGTMSTA 322
Query: 394 QLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPV 453
F +EA ++ F H +V L VC+ P+ ++ EYM KG L ++LR
Sbjct: 323 A--FLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGD-----GRY 375
Query: 454 EHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADF 513
H E IA Q+ASGM YL ++ +HRDLA RN LI ++ V KI DF
Sbjct: 376 LHFEDLIY------------IATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDF 423
Query: 514 GLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYF 573
GL+ ++ D Y + PV+W E+I+Y K++++SDVW+YG+ L E+F++ PY
Sbjct: 424 GLA-RVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYP 482
Query: 574 GMTHEEVVRFLKDENVLACPDN--TPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLI 631
GM EV+ ++ + P N P +Y L+ QCW+ P RP F + ++ +
Sbjct: 483 GMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVT 542
Query: 632 LE 633
E
Sbjct: 543 SE 544
>UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome
shotgun sequence; n=8; Clupeocephala|Rep: Chromosome 8
SCAF14552, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 714
Score = 165 bits (401), Expect = 3e-39
Identities = 98/278 (35%), Positives = 150/278 (53%), Gaps = 24/278 (8%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G FG V + + L E LVAVK L+ AS + F EA +L FDHPN++K
Sbjct: 359 IGAAQFGEVSRGRYRPLGRRE--VLVAVKTLRWGASDREKGMFLSEAGVLGQFDHPNVLK 416
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV P ++ E+M G L+ +LR F+ ++ +
Sbjct: 417 LEGVITRTPPERIVTEFMENGPLDSFLR--ENEGQFSVLQ----------------LVGM 458
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDY----YKGDEH 530
R I +GM YL++R FVHRDLA RN L+N ++V K++DFGLS + D+ Y
Sbjct: 459 LRGIGAGMRYLAERNFVHRDLAARNVLVNSNLVCKVSDFGLSRLMRGLDHNIPTYTASLG 518
Query: 531 DAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
IPVRW E+ + K++ SDVW++GV +WE+ S+ +PY+ M+++EV++ + D+ L
Sbjct: 519 SKIPVRWTAPEAFQHRKFSSASDVWSFGVLMWEVMSYGERPYWDMSNQEVMKAVADQYRL 578
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P + P ++ LM QCW + DRP F + +LD +
Sbjct: 579 PAPHSCPPALHSLMLQCWQADRGDRPAFETLLSSLDRL 616
>UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9;
Clupeocephala|Rep: C-Met receptor tyrosine kinase - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1382
Score = 164 bits (399), Expect = 6e-39
Identities = 94/268 (35%), Positives = 143/268 (53%), Gaps = 25/268 (9%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G+G FG VF L PD + A+K L + F +E ++ DF HPN++
Sbjct: 1085 IGRGHFGCVFHGTL--LEPDGQKQHCAIKSLNRITDIEEVSQFLKEGIIVKDFSHPNVLS 1142
Query: 415 LLGVC--AIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXX 472
LLG+C + G P+ +L YM GDL ++R S H
Sbjct: 1143 LLGICLPSEGSPLVVL-PYMKHGDLRNFIRDES---------HNPTVKDLMG-------- 1184
Query: 473 XIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYK-GDEHD 531
Q+A GM YL+ +KFVHRDLA RNC++++ VK+AD GL+ +Y ++YY ++H
Sbjct: 1185 -FGLQVAKGMEYLASKKFVHRDLAARNCMLDESYTVKVADVGLARDVYDKEYYSVHNKHG 1243
Query: 532 A-IPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
+PV+WM LES+ +K+T +SDVW++GV LWE+ + PY + ++ FL L
Sbjct: 1244 VKLPVKWMALESLQTHKFTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRL 1303
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
P+ P +Y++M +CW+ P RP F
Sbjct: 1304 LQPEFCPDALYNVMIECWHPKPERRPTF 1331
>UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|Rep:
Focal adhesion kinase - Aedes aegypti (Yellowfever
mosquito)
Length = 1092
Score = 164 bits (399), Expect = 6e-39
Identities = 86/249 (34%), Positives = 136/249 (54%), Gaps = 20/249 (8%)
Query: 380 VAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNE 439
VAVK K +A F EA ++ F+HP+I+KL+G+C+ G P+ ++ E G+L
Sbjct: 485 VAVKTCKADADLATSEKFLEEAYIMQKFEHPHIIKLIGICS-GSPIWIVMELARLGELRA 543
Query: 440 YLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRN 499
YL+ + + + Q+++ + YL +KFVHRD+A RN
Sbjct: 544 YLKKNGSKLKLGTL------------------LLYSYQLSTALSYLESKKFVHRDIAARN 585
Query: 500 CLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGV 559
L++ +K+ADFGLS + Q YY + +P++WM ESI + ++T SDVW +GV
Sbjct: 586 VLVSSPTCIKLADFGLSRWVEDQSYYTSTK-GMLPIKWMAPESINFRRFTTASDVWMFGV 644
Query: 560 CLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
C WEI ++P+ G+ + +V+ L++ L P N P +Y LM QCW++ P RPNF+
Sbjct: 645 CTWEILMLGVKPFQGIKNCDVIGKLENGERLPLPPNCPPRLYSLMSQCWSYEPHKRPNFK 704
Query: 620 VIYQTLDNI 628
I + L I
Sbjct: 705 NIKEVLYEI 713
>UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monosiga
ovata|Rep: Protein tyrosine kinase CSK - Monosiga ovata
Length = 468
Score = 164 bits (399), Expect = 6e-39
Identities = 105/293 (35%), Positives = 147/293 (50%), Gaps = 30/293 (10%)
Query: 338 KLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDF 397
K E I+ +G G FG VF+ GL ++ VA+K LKD + F
Sbjct: 204 KFVNWEISPREIVKSAQIGSGQFGDVFE----GLYRGQK---VAIKTLKDVQGDAID-QF 255
Query: 398 EREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHRE 457
EA + H N+V+L+GVC G P+ ++ E+MGKG L +YLR+
Sbjct: 256 LLEADTMTRLRHKNLVQLIGVCTQGSPIMIVSEFMGKGCLLDYLRSRGRAV--------- 306
Query: 458 XXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSH 517
R I + M YL ++KFVHRDLA RN L++DD V K+ADFGL+
Sbjct: 307 --------INLATQLGFCRDICAAMEYLEEQKFVHRDLAARNILLSDDGVAKVADFGLAK 358
Query: 518 KIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTH 577
L G +P++W E+I T +SDVW++GV LWEIF+F PY M
Sbjct: 359 DSQLGVTDIGK----LPIKWTAPEAIRLKVSTSKSDVWSFGVVLWEIFAFGRAPYPRMGQ 414
Query: 578 EEVVRFLKDENVLACPDNTPRCVYD-LMKQCWNHNPSDRPNFRVIYQTLDNIQ 629
+EVV + + CPD P+ VYD +M CW +P RP F+ + + L +IQ
Sbjct: 415 KEVVDAVVKGYRMECPDTCPKEVYDKIMMACWEIDPVKRPTFKTLMRALSSIQ 467
>UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor;
n=37; Euteleostomi|Rep: Tyrosine-protein kinase RYK
precursor - Homo sapiens (Human)
Length = 604
Score = 164 bits (399), Expect = 6e-39
Identities = 97/296 (32%), Positives = 147/296 (49%), Gaps = 12/296 (4%)
Query: 338 KLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDF 397
K++ + R I L +G FGR+F + VK +KD+AS
Sbjct: 316 KVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMM 375
Query: 398 EREACLLADFDHPNIVKLLGVCAI-GRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHR 456
E+C L H N++ + VC G ++ YM G+L +LR C V + P
Sbjct: 376 LTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNP---- 431
Query: 457 EXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLS 516
+A QIA GM YL+ R+ +H+DLA RNC+I+D + VKI D LS
Sbjct: 432 -------QAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALS 484
Query: 517 HKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
++ DY+ +++ PVRWM LES++ N+++ SDVWA+GV LWE+ + PY +
Sbjct: 485 RDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDID 544
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLIL 632
E+ +LKD +A P N P ++ +M CW +P +RP F+ + Q L L
Sbjct: 545 PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 600
>UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 311
Score = 164 bits (398), Expect = 7e-39
Identities = 96/293 (32%), Positives = 157/293 (53%), Gaps = 12/293 (4%)
Query: 345 PRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEE-FTLVAVKMLKDEASHDLQLDFEREACL 403
PR I ++ +G GAFG+V + + GL + +TLVA+K +AS D +E L
Sbjct: 8 PRERIHIMKVIGNGAFGQVHKGRVHGLGTNSPGWTLVAIKSPYADASDAETRDLMKEFEL 67
Query: 404 LADF-DHPNIVKLLGVCAI--GRPMCLLFEYMGKGDLNEYLRAC-STVTSFAPVEHREXX 459
L HP+++KLLG C GRP+ ++ EY+ GDL YLR S+ P +
Sbjct: 68 LKRLKSHPHVIKLLG-CGEDDGRPLVII-EYVPHGDLLGYLRKSRGEEDSYYP----DPE 121
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
A Q+A GM YLS +K +HRDLA RN L+ + V K+ DFG++ +
Sbjct: 122 IKPKTSLSSQQLVRFAWQVADGMQYLSSQKIIHRDLAARNILVGEGEVCKVTDFGMAKDV 181
Query: 520 YLQDYYKGDEHDAIPVRWMPLESIL-YNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
+D Y +PV+W +E+++ +YT +SDVW++GV L+EI + +PY G+ +
Sbjct: 182 QNEDIYIRTTEGRLPVKWTAIEALIGGGEYTTQSDVWSFGVVLYEICTIGGEPYPGIAGK 241
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLI 631
++ +L+ ++CP + +Y++M CW P RP F + + L+ ++ +
Sbjct: 242 DIPEYLEAGYRMSCPTHLDATLYEIMASCWATCPDMRPTFTSLEKLLNTLEAV 294
>UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=32;
Euteleostomi|Rep: Ephrin type-A receptor 2 precursor -
Homo sapiens (Human)
Length = 976
Score = 164 bits (398), Expect = 7e-39
Identities = 94/277 (33%), Positives = 149/277 (53%), Gaps = 24/277 (8%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V++ +E VA+K LK + ++DF EA ++ F H NI++
Sbjct: 619 IGAGEFGEVYKGMLKTSSGKKEVP-VAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIR 677
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV + +PM ++ EYM G L+++LR S + +
Sbjct: 678 LEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQL------------------VGM 719
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDA-- 532
R IA+GM YL++ +VHRDLA RN L+N ++V K++DFGLS L+D + +
Sbjct: 720 LRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSR--VLEDDPEATYTTSGG 777
Query: 533 -IPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLA 591
IP+RW E+I Y K+T SDVW++G+ +WE+ ++ +PY+ +++ EV++ + D L
Sbjct: 778 KIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLP 837
Query: 592 CPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P + P +Y LM QCW + RP F I LD +
Sbjct: 838 TPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKL 874
>UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 1193
Score = 163 bits (396), Expect = 1e-38
Identities = 100/280 (35%), Positives = 156/280 (55%), Gaps = 28/280 (10%)
Query: 355 LGQGAFGRVFQA--KAPGLIPDEEFTLVAVKMLKDE-ASHDLQLDFEREACLLADFDHPN 411
LG GAFG V++ + G D VA+K+LK+E A+ Q + RE ++A DH N
Sbjct: 847 LGSGAFGTVYKGHWRPEG---DPNCYEVAIKVLKEETATPQSQTELLREGAVMATMDHIN 903
Query: 412 IVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRAC-STVTSFAPVEHREXXXXXXXXXXXXX 470
+V+L VC +G+ M L+ E++ G L YL+ +T+ +++ +
Sbjct: 904 VVRLYCVC-MGKQMMLITEFVRLGSLLSYLKNNQATLDAYSMLN---------------- 946
Query: 471 XXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEH 530
+RQIA GM YL +++ VHRDLA RN L++ +VKI DFGL+ I + + +
Sbjct: 947 ---FSRQIADGMAYLEEKRMVHRDLAARNVLVHTPQLVKITDFGLTRIIDVGESHYKATG 1003
Query: 531 DAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
+P+RWM ESI +YT +SDVW++GV +WEI +F PY G +EV + +K+ L
Sbjct: 1004 GMVPLRWMAPESIFLFEYTHKSDVWSFGVTIWEILTFGRLPYKGKNGKEVSQLVKNGQQL 1063
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQL 630
P +Y L++QCW H+ + RP+F + +L N+ L
Sbjct: 1064 ERPATCDANLYHLLEQCWLHDQTKRPSFSALSNSL-NVML 1102
>UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2;
Culicidae|Rep: Tyrosine-protein kinase shark - Aedes
aegypti (Yellowfever mosquito)
Length = 939
Score = 163 bits (395), Expect = 2e-38
Identities = 96/278 (34%), Positives = 146/278 (52%), Gaps = 20/278 (7%)
Query: 345 PRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLL 404
P+ I+ + LG+G FG V+Q P + T +A+K L + ++DF REA ++
Sbjct: 654 PKECILTQKVLGRGEFGYVYQGLLRPQEPSD-CTPIAIKQLVESTGKRNRVDFLREASVM 712
Query: 405 ADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXX 464
H IVKL+G+C G P+ ++ E + G + +Y+ A + T +E
Sbjct: 713 IRLRHHCIVKLIGICK-GPPLMMVEELVPLGSMLDYIIA-NKGTINPKLE---------- 760
Query: 465 XXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL-QD 523
A QIA GM YL FVHRDLA RN L+ KI+DFGLS I D
Sbjct: 761 ------LVIWAAQIACGMQYLEQHHFVHRDLAARNILLASRNQAKISDFGLSRAIGAGDD 814
Query: 524 YYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRF 583
YY+ + P++W ES Y ++ SDVW++GV +WE++S PY M +V++
Sbjct: 815 YYRASQGGKWPIKWYAPESFNYGTFSHASDVWSFGVTMWEMYSLGAPPYQDMKGVDVIKL 874
Query: 584 LKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVI 621
+++ L+ PD P V+++MK CWN+NP RP F+ +
Sbjct: 875 IENGQRLSQPDLCPENVFEVMKNCWNYNPKSRPTFKFL 912
>UniRef50_UPI0000E47A46 Cluster: PREDICTED: similar to ret protein;
n=2; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to ret protein - Strongylocentrotus purpuratus
Length = 531
Score = 162 bits (394), Expect = 2e-38
Identities = 104/329 (31%), Positives = 160/329 (48%), Gaps = 9/329 (2%)
Query: 273 LLLSIGGLGCVLAIAGIALLCHYIVKNHYSKCNVSSRRNLQNMDIDLDKLPSNLAYHTTG 332
+LL G VL A+L + K S R L+N + D P
Sbjct: 211 VLLYSGVPALVLTCCIAAILVRFRRKRSKSSDETLFIRYLENGNSDKPPTPKVKRPSIDL 270
Query: 333 AQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHD 392
+P E EF R+ + ++LG G FG V++A A GL +E+ VAVK L+ A+
Sbjct: 271 TPKDPAFEGKEFDRSLLKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPG 330
Query: 393 LQLDFEREACLLADF-DHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFA 451
++ DF E L+ D HPNI++++G C + P L+ EYM GDL +L C
Sbjct: 331 MEEDFLNEIKLMIDLGQHPNILQIIGCCTVHEPNYLITEYMKYGDLLHFLWKCR------ 384
Query: 452 PVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIA 511
E + I RQI+ GM Y+ ++ H DLA RN L+ + + VK++
Sbjct: 385 --EDKYRRQDSIFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVS 442
Query: 512 DFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQP 571
DFGL+ IY Y + PV+W+ LE+ + T++SDVW++G+ ++EI++ P
Sbjct: 443 DFGLADDIYQSGYKRLAPDKKRPVKWVSLETNTIGRCTIQSDVWSFGIVMYEIYTLGGVP 502
Query: 572 YFGMTHEEVVRFLKDENVLACPDNTPRCV 600
Y GM E++ L++ + PD P V
Sbjct: 503 YPGMDGREIISKLQEGYRMPKPDQCPEDV 531
>UniRef50_UPI0000DB6C79 Cluster: PREDICTED: similar to PTK7 protein
tyrosine kinase 7 isoform a precursor; n=1; Apis
mellifera|Rep: PREDICTED: similar to PTK7 protein
tyrosine kinase 7 isoform a precursor - Apis mellifera
Length = 1112
Score = 162 bits (393), Expect = 3e-38
Identities = 93/332 (28%), Positives = 167/332 (50%), Gaps = 10/332 (3%)
Query: 302 SKCNVSSRRNLQNMDIDLDKLPSNLAYHTTGAQLNPK----LEKLEFPRNNIIYIRDLGQ 357
SK N ++ + +N D +K + + + K +K+ R+N+ ++ LG+
Sbjct: 780 SKMNSTANKKKENRDSSHNKSDGADTAQSQSSNQSKKSKSNYDKIAVSRSNLKELKPLGR 839
Query: 358 GAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLG 417
G FG V+ K + ++ +LV VK L + +F+R LL +H N+VKL+G
Sbjct: 840 GEFGEVYSTKYQ--VDGDKESLVMVKSLINTKDETALQEFKRHLDLLHKLNHENVVKLIG 897
Query: 418 VCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQ 477
+C P ++ EY GDL ++L A + +P E ++ Q
Sbjct: 898 LCREEEPDYMILEYTDWGDLKQFLIASRKDNTSSPTH--ESKAPRAPQLSVAQILSLSNQ 955
Query: 478 IASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRW 537
A G+ +L+D + VH+D+A RNCLI ++ +KI+ ++ + Y Q+Y K + IP+RW
Sbjct: 956 AAKGLKHLADTRLVHKDIAARNCLIASNLTIKISLPCMTKEPYQQEYTK-HRNQVIPLRW 1014
Query: 538 MPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDN-T 596
+P E++ ++Y+ +SDV+++ +WE+F P+ M E V+ LK + + P
Sbjct: 1015 LPYEAVYEDEYSTKSDVYSFSCLVWEMFHQGELPFNKMNDESVLAALKAQTLAWKPHKAA 1074
Query: 597 PRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P + +L QCW ++P +RP F + + I
Sbjct: 1075 PPSLQELQAQCWANDPRERPTFDEVVSKIGEI 1106
>UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon
nigroviridis|Rep: Ephrin receptor - Tetraodon
nigroviridis (Green puffer)
Length = 950
Score = 162 bits (393), Expect = 3e-38
Identities = 93/279 (33%), Positives = 146/279 (52%), Gaps = 27/279 (9%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G G FG V + + E +VA+K LK + + DF EA ++ FDHPN+++
Sbjct: 642 IGAGEFGEVCRGRLKQAGRRE--MVVAIKTLKAGYTERQRRDFLAEASIMGQFDHPNVIR 699
Query: 415 LLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXI 474
L GV P+ ++ E+M G L+ +LR +
Sbjct: 700 LEGVLTRSCPVLIITEFMENGALDSFLRL------------------NDGRFTMTQLVGM 741
Query: 475 ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDY-----YKGDE 529
R +A+GM YLSD +VHRDLA RN L+N ++V K++DFGLS +L D Y
Sbjct: 742 LRGVAAGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSR--FLDDTSADPTYTSSL 799
Query: 530 HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV 589
IP+RW E+I + K+T SDVW+YG+ +WE+ S+ +PY+ M++++V+ ++ +
Sbjct: 800 GGKIPIRWTAPEAIAFRKFTTASDVWSYGIVMWEVVSYGERPYWDMSNQDVMTAVEQDYR 859
Query: 590 LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L P + P ++ LM +CW + RP F I TLD +
Sbjct: 860 LPPPMDCPMVLHQLMLECWMKERNLRPKFSRIVGTLDKL 898
>UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein
tyrosine kinase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to protein tyrosine kinase - Nasonia
vitripennis
Length = 739
Score = 161 bits (392), Expect = 4e-38
Identities = 100/281 (35%), Positives = 145/281 (51%), Gaps = 20/281 (7%)
Query: 339 LEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFE 398
L ++ P NII LG+G FG V++ P VA+KML+D + + +F
Sbjct: 454 LTQVFVPGENIILGEVLGEGEFGAVYEGLFDS--PSGTQEPVAIKMLRDTHNIATREEFL 511
Query: 399 REACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREX 458
REA L+ F+H IVKL+G G P+ ++ E + G + YL +E +
Sbjct: 512 REARLMMTFNHHCIVKLIGFSE-GPPLLMVQELVSLGSMLAYL-----------LEFPDR 559
Query: 459 XXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHK 518
A QIA GM YL + + VHRDLA RN L+ KI+DFGLS
Sbjct: 560 INPNYELKVW------ASQIACGMKYLEEIRLVHRDLAARNILLASKHQAKISDFGLSRT 613
Query: 519 IYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHE 578
DYYK P++W ES Y ++ SDVW+YG+ LWE+FS+ QPY
Sbjct: 614 FGSNDYYKATAGGKWPIKWYAPESYNYGTFSHASDVWSYGITLWEMFSYGEQPYGDRRGT 673
Query: 579 EVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
EV+ ++ + LA P+ P VY +M++CW+++P+DRP F+
Sbjct: 674 EVIDLVEKGDRLAQPEQCPDHVYKVMQKCWSYSPADRPTFQ 714
>UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome
shotgun sequence; n=3; Fungi/Metazoa group|Rep:
Chromosome 3 SCAF14978, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 958
Score = 161 bits (392), Expect = 4e-38
Identities = 100/289 (34%), Positives = 146/289 (50%), Gaps = 23/289 (7%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
EK + R++II + LG+G FG V E VA+K K+ S D++ F
Sbjct: 378 EKYKISRDDIIVGQILGEGFFGEVHNGVYK--TQTGENLSVAIKTCKN-CSADVKEKFLS 434
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ + DHP+IV+L+GV P+ ++ E G+L +YL VE +
Sbjct: 435 EASVMKNLDHPHIVRLIGVIEAD-PVWIVMELYEHGELGKYL-----------VEQQ--- 479
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
QI + YL VHRD+A RN L+ + VK+ DFGLS I
Sbjct: 480 ----YSLTTVMLITYCLQICKALAYLEGLNVVHRDIAVRNILVASPLCVKLGDFGLSRYI 535
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
++YYK +P++WM ESI + ++T SDVW +GVC+WEIFS A QP+F + + +
Sbjct: 536 EEEEYYKASA-SRLPIKWMAPESINFRRFTTASDVWMFGVCVWEIFSMAQQPFFWLENSQ 594
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
V+ L+ L P P VY L+ CW+H P RP F + +L I
Sbjct: 595 VIDQLESGIRLPKPQLCPPTVYSLVSSCWSHEPHLRPQFSHLACSLSEI 643
>UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 557
Score = 161 bits (390), Expect = 7e-38
Identities = 91/278 (32%), Positives = 140/278 (50%), Gaps = 18/278 (6%)
Query: 356 GQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKL 415
G+G+F +V++ + T VAVK +K S F E ++ HPN++ +
Sbjct: 293 GEGSFSKVYRGTLHQM--GTGTTEVAVKAMKSIESDAEMKSFFTECSVMQTLKHPNVLGI 350
Query: 416 LGVCAIGRPMC--LLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXX 473
LG+C ++ +M G+L +YL+ +HR
Sbjct: 351 LGMCFDSPDSIPLMVLPFMVNGNLKDYLK-----------KHRGPHLQLETYPENLSLQM 399
Query: 474 IAR---QIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEH 530
+ R I GM YL+DR+FVHRDLA RNCL++ + VK+ DFGL+ IYL +YY+
Sbjct: 400 LKRICVDITRGMSYLADRRFVHRDLAARNCLLDSALAVKVGDFGLTRDIYLTNYYRAPTE 459
Query: 531 DAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
+PV+WMP E + ++DVW++GV WE+FSF PY G+ + +++ L L
Sbjct: 460 TKLPVKWMPPEMLQDGVSDEKTDVWSFGVTCWEVFSFGSTPYPGVDNHLMLQHLMSGLRL 519
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
P P +Y LM +CW+ NP DRP F +++ I
Sbjct: 520 QKPLLCPDEIYTLMARCWSSNPEDRPTFNELFKEFSAI 557
>UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23;
Theria|Rep: Tyrosine-protein kinase SYK - Homo sapiens
(Human)
Length = 635
Score = 161 bits (390), Expect = 7e-38
Identities = 99/277 (35%), Positives = 143/277 (51%), Gaps = 25/277 (9%)
Query: 353 RDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHD-LQLDFEREACLLADFDHPN 411
++LG G FG V K + VAVK+LK+EA+ L+ + EA ++ D+P
Sbjct: 375 KELGSGNFGTV---KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431
Query: 412 IVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXX 471
IV+++G+C M L+ E G LN+YL+ V +E
Sbjct: 432 IVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIE----------------- 473
Query: 472 XXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL-QDYYKGDEH 530
+ Q++ GM YL + FVHRDLA RN L+ KI+DFGLS + ++YYK H
Sbjct: 474 --LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH 531
Query: 531 DAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
PV+W E I Y K++ +SDVW++GV +WE FS+ +PY GM EV L+ +
Sbjct: 532 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM 591
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
CP PR +YDLM CW ++ +RP F + L N
Sbjct: 592 GCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628
>UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor receptor
2; n=11; Clupeocephala|Rep: Plasminogen related growth
factor receptor 2 - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1375
Score = 160 bits (389), Expect = 9e-38
Identities = 93/283 (32%), Positives = 146/283 (51%), Gaps = 25/283 (8%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVK 414
+G+G FG V+ + +++ T AVK L F RE ++ FDHPNI+
Sbjct: 1071 IGKGHFGTVYHGYL--IDSNKQETHCAVKSLNRITDLKDVDHFLREGLIMKGFDHPNILS 1128
Query: 415 LLGVCAI--GRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXX 472
LLG+ G P+ +L YM GD+ ++R+ E R
Sbjct: 1129 LLGIMLPKEGLPLVVL-PYMKHGDVRHFIRS----------EKRNPTVKDLIG------- 1170
Query: 473 XIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDA 532
Q+A GM YL+ +KFVHRDLA RNC++++ VK+ADFG++ IY ++YY +H
Sbjct: 1171 -FGLQVAKGMEYLAQKKFVHRDLAARNCMLDETYTVKVADFGMARDIYDKEYYSIQDHKQ 1229
Query: 533 I--PVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
+ PV+WM +ES+ K+T +SDVW+YG+ +WE+ + PY + ++ +L L
Sbjct: 1230 VKLPVKWMAIESLQTQKFTSKSDVWSYGILMWELLTRGASPYPDVDPYDITNYLLKGRRL 1289
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILE 633
P P +Y +M CW+ P RP+F + + +I L L+
Sbjct: 1290 PQPQFCPNTLYSIMLSCWDPEPDFRPSFSSLASDVQHILLCLQ 1332
>UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine
protein kinase BTK; n=1; Danio rerio|Rep: PREDICTED:
similar to tyrosine protein kinase BTK - Danio rerio
Length = 596
Score = 160 bits (388), Expect = 1e-37
Identities = 101/309 (32%), Positives = 158/309 (51%), Gaps = 36/309 (11%)
Query: 322 LPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVA 381
+P + YH A + +++ PR + +IR+LG G FG V K G VA
Sbjct: 315 IPELINYHQHNAAGSWEID----PRQ-LTFIRELGNGQFGVVKYGKWQGRHD------VA 363
Query: 382 VKMLKDEA-SHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEY 440
+KM+K+ + S D DF EA ++ H N+V+L GVC RP+ ++ EY+ G L Y
Sbjct: 364 IKMVKEGSMSED---DFIEEAKVMMKLCHGNLVQLYGVCTKQRPIYIVTEYLANGCLLNY 420
Query: 441 LR-ACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRN 499
L+ TS A +E + + ++ GM YL +F+HRDLA RN
Sbjct: 421 LQEGLLNPTSIALLE-------------------MCKDVSEGMKYLEANQFIHRDLAARN 461
Query: 500 CLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGV 559
CL++ + +K+ DFGLS + L D Y PVRW P E +LY K++ +SD+WA+GV
Sbjct: 462 CLVDSNGTIKVTDFGLSRYV-LDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKSDIWAFGV 520
Query: 560 CLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFR 619
+WEI++ PY + E+V + + L P V+ +M CW+ P +RP F+
Sbjct: 521 LMWEIYTQGRMPYDRWNNTEIVEKISAGHRLYRPQMANENVFAIMNSCWHERPDERPTFQ 580
Query: 620 VIYQTLDNI 628
+ + ++
Sbjct: 581 ELVGVIKDL 589
>UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein;
n=1; Suberites domuncula|Rep: Bruton's tyrosine
kinase-like protein - Suberites domuncula (Sponge)
Length = 700
Score = 160 bits (388), Expect = 1e-37
Identities = 100/286 (34%), Positives = 149/286 (52%), Gaps = 26/286 (9%)
Query: 340 EKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFER 399
E E + ++ ++LG G FGRV K G I VA+KM+++ A ++ DF
Sbjct: 424 EAWEIDKVSLSLGKELGSGQFGRVVSGKWKGKID------VAIKMMREGAMNED--DFIE 475
Query: 400 EACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXX 459
EA ++ F H N+VKL GVC P+ ++ E M G L ++LR + VE E
Sbjct: 476 EAKVMKQFQHENLVKLYGVCTKNGPIFIVQELMVNGCLLQFLRQRKEL-----VEKTEII 530
Query: 460 XXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKI 519
+A QI S M YL + F+HRDLA RNCL+ + VVK+ADFGL+ +
Sbjct: 531 LD------------MATQICSAMKYLEESGFIHRDLAARNCLVGERNVVKVADFGLA-RF 577
Query: 520 YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEE 579
+ D Y E P++W E I + K++ +SDVW++G+ LWE+++ PY T+ +
Sbjct: 578 VVDDEYTASEGTKFPIKWAAPEVITHAKFSSKSDVWSFGILLWELWTGGKTPYPTFTNSQ 637
Query: 580 VVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTL 625
V+ + L P P VY LM +CW N DRP F+ + +L
Sbjct: 638 VLDEVLMGYRLDRPKQCPPEVYALMGKCWLTNSDDRPQFKTLSSSL 683
>UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa
group|Rep: Src family kinase - Asterina miniata (Bat
star) (Patiria miniata)
Length = 563
Score = 160 bits (388), Expect = 1e-37
Identities = 99/285 (34%), Positives = 144/285 (50%), Gaps = 27/285 (9%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREAC 402
E PR +I R LG G FG V++ G + VAVK LK+ A F +EA
Sbjct: 296 EIPRRSIKLERKLGNGQFGEVWEGTWNGTVR------VAVKTLKEGAMDPTA--FLQEAN 347
Query: 403 LLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
++ HP +V LL VC+ G P+ ++ E M G L +YL P
Sbjct: 348 IMKKLRHPKLVALLAVCSEGEPIYIVTELMTNGCLLDYLHEGEGKQLREP---------- 397
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ 522
I Q+A GM YL ++FVHRDLA RN L+ D K+ADFGLS I +
Sbjct: 398 -------ELIDITAQVADGMAYLESQRFVHRDLAARNILVGDLRNCKVADFGLSRII--E 448
Query: 523 DYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVR 582
D Y E +P++W E+I + K+T++SDVW++G+ ++E+ + PY GM + EV+
Sbjct: 449 DEYIAKEGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRVPYPGMVNREVLD 508
Query: 583 FLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
+ + P P +YD+ KQCW+ P RP F ++ LD+
Sbjct: 509 QVSRGYRMPKPPECPDQLYDITKQCWDAVPEKRPTFEFLHSFLDD 553
>UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2;
Anthomedusae|Rep: Protein-tyrosine kinase - Hydractinia
echinata (Snail fur) (Hermit crab hydroid)
Length = 1162
Score = 160 bits (388), Expect = 1e-37
Identities = 96/293 (32%), Positives = 148/293 (50%), Gaps = 27/293 (9%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ-----LDF 397
E R+++ +GQG FG V+Q I E VAVK K E + + F
Sbjct: 423 EVARDDLTLDEIIGQGQFGDVYQGTFKSKISSVEIP-VAVKTYKIELDKEQEDGTRAEKF 481
Query: 398 EREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHRE 457
EA L+ FDHP+++KL+G+ + P ++ E G+L YL+ T T
Sbjct: 482 LEEAYLMQQFDHPHVIKLIGIVS-DSPSYIIMELASYGELRSYLQQYRTQTE-------- 532
Query: 458 XXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSH 517
Q+++ + YL R FVHRD+A RN L D +K+ADFGLS
Sbjct: 533 ----------SERLLTYIYQLSTALSYLESRNFVHRDIAARNILAADPHTIKLADFGLSR 582
Query: 518 KI-YLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMT 576
I Q YYK + +P++WM ESI + +++ SDVW +GVC WEI + ++P+ G+
Sbjct: 583 WIDEEQSYYKASK-GKLPIKWMAPESINFRRFSSASDVWMFGVCCWEILMYGVKPFQGVP 641
Query: 577 HEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQ 629
+E+V+ +++ L P N +Y LM + W++ PS RP F+ + L I+
Sbjct: 642 NEKVIGKIENGERLPLPPNCAPTLYHLMTESWHYEPSKRPTFQELKSRLSQIK 694
>UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n=2;
Ascidiacea|Rep: Gamma-carboxyglutamic acid protein 1 -
Ciona intestinalis (Transparent sea squirt)
Length = 556
Score = 160 bits (388), Expect = 1e-37
Identities = 90/268 (33%), Positives = 141/268 (52%), Gaps = 28/268 (10%)
Query: 358 GAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLG 417
G FG V++ K + VAVK LK +H+ F RE ++ DH N++ L+G
Sbjct: 181 GNFGDVYRGKLRSR--QNTWHDVAVKSLKSLENHEDVEKFLREGVMMRGLDHRNVLALIG 238
Query: 418 VCAIGR-------PMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXX 470
VC G P+ +L +M GDL +LR + V + +
Sbjct: 239 VCVDGEVERLQTSPLIIL-PFMENGDLRTFLRDGNNVLTVLKL----------------- 280
Query: 471 XXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEH 530
+ +A GM YL+++KFVHRDLA RNC+++ + VK+ADFGLS ++ +DYY+
Sbjct: 281 -LKFCKDVAMGMEYLAEKKFVHRDLAARNCMVDKNWCVKVADFGLSRDLFDRDYYRSSVK 339
Query: 531 DAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVL 590
+P++WMP ESI Y +Y +SDVW+YG+ WEI + PY + ++++L + N +
Sbjct: 340 TQLPLKWMPPESIKYGRYGEKSDVWSYGIVCWEIMTRGAIPYPTVQAVAILQYLSEGNRM 399
Query: 591 ACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
P+ P +Y M++CW + RP F
Sbjct: 400 ERPECCPHKLYKTMEKCWLDDTERRPTF 427
>UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14979, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1078
Score = 159 bits (387), Expect = 2e-37
Identities = 94/286 (32%), Positives = 149/286 (52%), Gaps = 22/286 (7%)
Query: 369 PGLIPDEEFTLVAVKMLKDEASH-------DLQL--DFEREACLLADFDHPNIVKLLGVC 419
P L+ + + L+ ML+ E S DL+ F RE ++ FDHPNI+ LLG+
Sbjct: 751 PDLLEEVKNVLIPADMLRIEDSQIIGKGITDLKEVNQFLREGLIMKGFDHPNILSLLGIM 810
Query: 420 AI--GRPMCLLFEYMGKGDLNEYLRACSTVTSFA-----PVEHREXXXXXXXXXXXXXXX 472
G P+ +L YM GD+ ++R+ V ++RE
Sbjct: 811 LPKEGLPLVVL-PYMKHGDVRHFIRSEKRVFICICGLTKQEDNRELCLTFLCLPQNPTVK 869
Query: 473 XI---ARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDE 529
+ Q+A GM YL+ +KFVHRDLA RNC++++ VK+ADFG++ IY ++YY +
Sbjct: 870 DLIGFGLQVAKGMEYLAQKKFVHRDLAARNCMLDETYTVKVADFGMARDIYDKEYYSIQD 929
Query: 530 HDAI--PVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDE 587
H + PV+WM LES+ K+T++SDVW+YG+ +WE+ + PY + ++ +L
Sbjct: 930 HKQVKLPVKWMALESLQTQKFTIKSDVWSYGILMWELLTRGASPYPDVDPYDITHYLLKG 989
Query: 588 NVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILE 633
L P P +Y +M CW+ P RP+F + + +I L L+
Sbjct: 990 RRLPQPQFCPDTLYSIMLSCWDPEPDYRPSFSSLTADVQHILLCLQ 1035
>UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to
tyrosine-protein kinase pr2; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to tyrosine-protein
kinase pr2 - Nasonia vitripennis
Length = 1345
Score = 159 bits (386), Expect = 2e-37
Identities = 108/318 (33%), Positives = 159/318 (50%), Gaps = 27/318 (8%)
Query: 320 DKLPSNLAYHTTGAQLNPKLE---KLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEE 376
+ +P +LA Q P + K P + II ++LG G FG V Q D E
Sbjct: 142 EPMPGSLAMLPEERQDRPPIRVPNKHMIPADAIIVNKELGTGEFGVVQQGVWTN---DGE 198
Query: 377 FTLVAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGD 436
VA+K L E + ++F +EA ++ DH +IV+L GV + L+ E
Sbjct: 199 RIQVAIKCLSRERMQNNPIEFLKEAAIMHSIDHEHIVRLYGVVLDTNSLMLVTELAPLRS 258
Query: 437 LNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLA 496
L E L+ S SF PV + QIA GM YL ++ +HRDLA
Sbjct: 259 LLECLKEPSLRASF-PVP---------------SLCDFSVQIADGMQYLEAKRLIHRDLA 302
Query: 497 TRNCLINDDMVVKIADFGLSHKIYL-QDYYKGDEHD--AIPVRWMPLESILYNKYTLESD 553
RN L+ VKI+DFGLS + + +DYY+ + + +P+ W E I Y K+T SD
Sbjct: 303 ARNILVFSKNKVKISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECISYLKFTSASD 362
Query: 554 VWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV--LACPDNTPRCVYDLMKQCWNHN 611
VWAYGV LWE+FS+ QP+ +T +++ + + N L PD P+ + LM+QCW H
Sbjct: 363 VWAYGVTLWEMFSYGFQPWAALTGHQILEAIDEPNFQRLEQPDCCPKDYFSLMQQCWQHE 422
Query: 612 PSDRPNFRVIYQTLDNIQ 629
P+ RP F + L +++
Sbjct: 423 PTKRPKFSELICLLPDLK 440
>UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 522
Score = 159 bits (386), Expect = 2e-37
Identities = 96/298 (32%), Positives = 149/298 (50%), Gaps = 13/298 (4%)
Query: 335 LNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQ 394
L KL R+ I L +G FGRV Q D E V +K + D +S + +
Sbjct: 234 LRLKLAPYAIERSRITLGEVLLEGTFGRVHQGVLISATGDSEQD-VFIKTVTDHSSEEQR 292
Query: 395 LDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVE 454
+E+CLL H NI+ LL VC P +L +M G+L ++L+ P +
Sbjct: 293 HLLVKESCLLQGLSHKNILPLLHVC-FSDPPFILEAFMKLGNLKQFLKN----GRIGPGD 347
Query: 455 HREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFG 514
+ +A QI GM+YL ++ VH+DLATRNC+I++D +KI D
Sbjct: 348 KHQAISTRDLVH-------LAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNA 400
Query: 515 LSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFG 574
LS ++ DY+ +++ PV+WM +ES+++ K++ SDVW++GV LWE+ + PY
Sbjct: 401 LSRDLFPSDYHCLGDNENRPVKWMAVESLVHKKFSHASDVWSFGVTLWELVTLGQTPYMD 460
Query: 575 MTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLIL 632
+ E+ FLK + P + P +++LM CW P DRP F + L + L
Sbjct: 461 LDPFEMATFLKSGYRMPQPPSCPDELFNLMACCWALLPQDRPKFSQLCAALTDFHRTL 518
>UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like
tyrosine kinase CG3969-PA, isoform A; n=1; Apis
mellifera|Rep: PREDICTED: similar to Fak-like tyrosine
kinase CG3969-PA, isoform A - Apis mellifera
Length = 1270
Score = 159 bits (386), Expect = 2e-37
Identities = 103/290 (35%), Positives = 150/290 (51%), Gaps = 24/290 (8%)
Query: 345 PRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDFEREACLL 404
P + II ++LG G FG V Q D E VA+K L E + ++F +EA ++
Sbjct: 112 PADAIIVNKELGTGEFGVVQQGVWTN---DGERIQVAIKCLSRERMQNNPIEFLKEAAIM 168
Query: 405 ADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXX 464
DH +IV+L GV + L+ E L E L+ S +SF PV
Sbjct: 169 YAIDHEHIVRLYGVVLDTNSLMLVTELAPLRSLLECLKEPSLRSSF-PV----------- 216
Query: 465 XXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL-QD 523
+ QIA GM YL ++ +HRDLA RN L+ VKI+DFGLS + + +D
Sbjct: 217 ----LSLCDFSVQIADGMQYLEAKRLIHRDLAARNILVFSKNKVKISDFGLSRALGVGKD 272
Query: 524 YYKGDEHD--AIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
YY+ + + +P+ W E I Y K+T SDVWAYGV LWE+FS+ QP+ +T +++
Sbjct: 273 YYQTNFNVNLKLPIAWCAPECISYLKFTSASDVWAYGVTLWEMFSYGFQPWAALTGHQIL 332
Query: 582 RFLKDENV--LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQ 629
+ D N L P+ P+ + LM+QCW H PS RP F + L +++
Sbjct: 333 EAIDDPNFQRLEQPECCPKEYFSLMQQCWQHEPSKRPKFSELINLLPDLK 382
>UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Receptor tyrosine kinase - Schistosoma
mansoni (Blood fluke)
Length = 1559
Score = 159 bits (386), Expect = 2e-37
Identities = 90/289 (31%), Positives = 159/289 (55%), Gaps = 25/289 (8%)
Query: 338 KLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHDLQLDF 397
+L+ ++ P +I+ R +GQGAFG V+ +A + + VAVK++ ++++++ + DF
Sbjct: 985 ELKDIDIPPADIVLNRRVGQGAFGMVYGGEAKR---NGRWEAVAVKVIGNKSTYEGKTDF 1041
Query: 398 EREACLLADFDHPNIVKLLGVCAIGRP--MCLLFEYMGKGDLNEYLRACSTVTSFAPVEH 455
EA L+ DH N+V+L+G+C + + L+ E+M GDL YL + + P +H
Sbjct: 1042 LSEAKLMRSLDHRNVVRLVGICLYPKENHLYLIMEFMLNGDLKTYLLSRRVLAQQVP-DH 1100
Query: 456 REXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGL 515
+A IA G+ YL + +HRD+A RNCL+ D +VKI DFGL
Sbjct: 1101 --------DGVCPATLTGMAIDIAEGLAYLHRKNLIHRDIACRNCLVGSDGIVKIGDFGL 1152
Query: 516 SHKIYLQD---YYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPY 572
+ ++ + YY+ + +P+RWM E++ + +++ SD+W+YG+ L+EI +F + PY
Sbjct: 1153 TREMNSSENEGYYRFTRNCELPIRWMSPEAVQFGIFSVHSDIWSYGIVLYEIITFGVFPY 1212
Query: 573 FGMTHEEVVRFLKDENV-------LACPDNT-PRCVYDLMKQCWNHNPS 613
G++ E+V +K ++ LA + T R +Y + W H P+
Sbjct: 1213 DGLSDVEIVERVKRKDFSIIQFLPLAARNTTISRLIYQCCQHQWQHRPA 1261
>UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Ciona
intestinalis|Rep: Ephrin receptor like protein - Ciona
intestinalis (Transparent sea squirt)
Length = 1085
Score = 159 bits (386), Expect = 2e-37
Identities = 94/283 (33%), Positives = 144/283 (50%), Gaps = 19/283 (6%)
Query: 355 LGQGAFGRVFQAKAPGLIPDEEFTL--VAVKMLKDEASHDLQLDFEREACLLADFDHPNI 412
+G G FG V+Q + + VA+K L + + Q+DF EA L F HPNI
Sbjct: 722 IGCGEFGEVYQGSLTLTDTGGKRKVIDVAIKQLHAQCQPNEQIDFLHEAKALERFQHPNI 781
Query: 413 VKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXX 472
VKL V RP ++ E M G L ++LR HR
Sbjct: 782 VKLEAVVMASRPFMIVTELMVNGCLGKFLR-----------HHR----GAKRYFKPTVLV 826
Query: 473 XIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDA 532
+ +A GM YLS +VHRDLA RN LIN+++V K+ADFGL I + +
Sbjct: 827 RMLHGVAKGMAYLSKMCYVHRDLAARNVLINNELVCKVADFGLIRHIGEKKSTVNTKGGK 886
Query: 533 IPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLAC 592
I +RW E++ Y Y+ SDVW++GV WE+ ++ +PY+ +T+++V++ + D L
Sbjct: 887 ISLRWTAPEAVAYQAYSQASDVWSFGVFAWEVITYGEKPYWSLTNQQVLQAINDGYRLPA 946
Query: 593 PDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILERG 635
P++ P ++ LM +CW+ + + RP F + LD +I +RG
Sbjct: 947 PEDCPSVLHQLMLECWHRDKNTRPTFEQVVTRLD--AMINQRG 987
>UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=2;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor c - Nematostella vectensis
Length = 297
Score = 159 bits (385), Expect = 3e-37
Identities = 97/286 (33%), Positives = 141/286 (49%), Gaps = 6/286 (2%)
Query: 345 PRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTL-VAVKMLKDEASHDLQLDFEREACL 403
P +NII LG G FG V + + + D+ T+ AVK +K AS + D +E L
Sbjct: 12 PTSNIILHEYLGSGEFGVVTRGE---MTTDDGRTVDCAVKSIKGFASEEALRDLVQELEL 68
Query: 404 LADFDHP-NIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXX 462
+ H N++ L+G C + ++ E+ G L + L +
Sbjct: 69 MHSVGHHRNLLNLIGACTDSEKLMIIVEFANDGCLLDLLHQARGDLQSPRIYQNIEPRHS 128
Query: 463 XXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQ 522
IA +A GM YL+ ++ VHRDLA RN LI D V K+ADFGLS IY
Sbjct: 129 EVVLGQTRRLEIALDVAQGMDYLASKRCVHRDLAARNVLIADG-VAKVADFGLSRNIYET 187
Query: 523 DYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVR 582
Y+ +P RWM LES+ K+TLESDVW+YGV LWEI + L P G+ + E++
Sbjct: 188 GEYEKTTRGKLPTRWMSLESLETRKFTLESDVWSYGVLLWEIETRGLTPNAGLNYREMIA 247
Query: 583 FLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
+ L P + + +Y++M++CW P RP F I + L +
Sbjct: 248 RYRKGYRLERPPDCDQGLYEIMRRCWLAIPKSRPTFSDIVEQLTEL 293
>UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming
protein SEA; n=6; root|Rep: Tyrosine-protein kinase
transforming protein SEA - Avian erythroblastosis virus
(strain S13)
Length = 370
Score = 159 bits (385), Expect = 3e-37
Identities = 99/306 (32%), Positives = 155/306 (50%), Gaps = 27/306 (8%)
Query: 334 QLNPKLEKLEFPRNNIIYIRD--LGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASH 391
+L +++ + P +I R +G+G FG V+ + P AVK L
Sbjct: 43 ELLEEVKDILIPEERLITHRSRVIGRGHFGSVYHGTY--MDPLLGNLHCAVKSLHRITYL 100
Query: 392 DLQLDFEREACLLADFDHPNIVKLLGVCAI--GRPMCLLFEYMGKGDLNEYLRACSTVTS 449
+ +F RE L+ F HP ++ LLGVC G P+ +L YM GDL ++RA +
Sbjct: 101 EEVEEFLREGILMKGFHHPQVLSLLGVCLPRHGLPLVVL-PYMRHGDLRHFVRAQERSPT 159
Query: 450 FAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVK 509
+ Q+A GM YL+ +KFVHRDLA RNC++++ + VK
Sbjct: 160 VKEL------------------IGFGLQVALGMEYLAQKKFVHRDLAARNCMLDETLTVK 201
Query: 510 IADFGLSHKIYLQDYY--KGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSF 567
+ADFGL+ ++ ++YY + H +PVRWM LES+ K+T +SDVW++GV +WE+ +
Sbjct: 202 VADFGLARDVFGKEYYSIRQHRHAKLPVRWMALESLQTQKFTTKSDVWSFGVLMWELLTR 261
Query: 568 ALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDN 627
PY + ++ R+L L P P +Y +M CW P +RP+F + L+
Sbjct: 262 GASPYPEVDPYDMARYLLRGRRLPQPQPCPDTLYGVMLSCWAPTPEERPSFSGLVCELER 321
Query: 628 IQLILE 633
+ LE
Sbjct: 322 VLASLE 327
>UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 485
Score = 158 bits (384), Expect = 4e-37
Identities = 93/289 (32%), Positives = 149/289 (51%), Gaps = 29/289 (10%)
Query: 345 PRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKDEASHD-LQLDFEREACL 403
P+ +++ +G+G FG V+ + D E VA+K +KD + + F EA +
Sbjct: 222 PKASLLKKSLIGKGEFGEVW-------LGDYEGKKVAMKSMKDHLKDEKAKTQFLAEASV 274
Query: 404 LADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXX 463
+ HPN+V L+G+ P+ L+ E+M KG L +YLR+
Sbjct: 275 MTTLRHPNLVCLIGISLDDNPIYLITEFMAKGSLIDYLRSRGRAV--------------- 319
Query: 464 XXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQD 523
AR + GM+YL + FVHRDLA RN LI +D V K++DFGL+
Sbjct: 320 --ITKQNQIDFARDVVKGMVYLESQNFVHRDLAARNVLIAEDNVAKVSDFGLAKS---SS 374
Query: 524 YYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRF 583
K E +PV+W E++ NK++ ++DVW++GV LWEI+S+ PY + E+V
Sbjct: 375 NVK-QEGAKLPVKWTAPEALRENKFSNKTDVWSFGVLLWEIYSYGRVPYPRVPVEDVANH 433
Query: 584 LKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLIL 632
+++ + PD P +Y +M CW +PS RPNF I + L+++ + +
Sbjct: 434 VENGYRMESPDGCPDQIYKIMMDCWEKDPSQRPNFTRIEKALESVAVAM 482
>UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase X - Ciona
intestinalis (Transparent sea squirt)
Length = 478
Score = 158 bits (384), Expect = 4e-37
Identities = 95/305 (31%), Positives = 160/305 (52%), Gaps = 29/305 (9%)
Query: 334 QLNPKLEKLEFPRNNIIYIRD--LGQGAFGRVFQ-----AKAPGLIPDEEFTLVAVKMLK 386
Q+ ++ + RN ++ ++ +G+G FG V+ ++ L + VA+K L
Sbjct: 127 QILQEMSSVLISRNKLMVDKENIIGKGHFGTVYNGEYITSEISKLNGNPIKRKVAIKTLS 186
Query: 387 DEASHDLQLDFEREACLLADFDHPNIVKLLGVC--AIGRPMCLLFEYMGKGDLNEYLRAC 444
+ F +E +++DF N++ L+G+ G PM +L YM GDL +++R
Sbjct: 187 KIEDTESVEKFLKEGLMMSDFHDENVLTLIGISWDDDGAPMVVL-PYMMHGDLLQFIRKP 245
Query: 445 STVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLIND 504
S + + Q GM YL+ ++FVHRDLA RNC++N+
Sbjct: 246 SNNPTVKDL------------------VGFGLQACKGMCYLASQRFVHRDLAARNCMLNE 287
Query: 505 DMVVKIADFGLSHKIYLQDYYKGDEHDA-IPVRWMPLESILYNKYTLESDVWAYGVCLWE 563
VVK+ADFGL+ IY ++YYK EH +PV+WM LES+ +T+++DVW++G+ LWE
Sbjct: 288 TYVVKVADFGLARDIYEKEYYKPHEHAGRMPVKWMALESLQQQTFTIKTDVWSFGILLWE 347
Query: 564 IFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQ 623
+ + + PY + +VV ++ D L P P +Y+LM CW+ P RP+F + +
Sbjct: 348 LLTRGVTPYPDVDAFDVVNYILDGRRLRQPQYCPDPLYELMLSCWHPLPETRPDFVTLVR 407
Query: 624 TLDNI 628
++ I
Sbjct: 408 KIEQI 412
>UniRef50_UPI000065D1E0 Cluster: BDNF/NT-3 growth factors receptor
precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase
receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB)
(Trk-B).; n=1; Takifugu rubripes|Rep: BDNF/NT-3 growth
factors receptor precursor (EC 2.7.10.1) (Neurotrophic
tyrosine kinase receptor type 2) (TrkB tyrosine kinase)
(GP145-TrkB) (Trk-B). - Takifugu rubripes
Length = 696
Score = 158 bits (383), Expect = 5e-37
Identities = 86/202 (42%), Positives = 120/202 (59%), Gaps = 8/202 (3%)
Query: 328 YHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLKD 387
+ +T + L R+NI+ R+LG+GAFG+VF A+ L PD+E LVAVK LK
Sbjct: 354 FRSTNSLLKTDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLSPDQEKILVAVKTLK- 412
Query: 388 EASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTV 447
EAS + + DF+REA LL + H +IV GVC P+ ++FEYM GDLN+ + +
Sbjct: 413 EASENARKDFQREAELLTNLQHEHIVTFYGVCVESDPLIMVFEYMKHGDLNKAHGPDAVL 472
Query: 448 TSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMV 507
+ E IA+QIASGM+YL+ + FVHRDLATRNCL+ ++++
Sbjct: 473 MT-------EGQTTRPVELTQSQMLHIAQQIASGMVYLASQHFVHRDLATRNCLVGENLL 525
Query: 508 VKIADFGLSHKIYLQDYYKGDE 529
VKI DFG+S +Y DYY+ E
Sbjct: 526 VKIGDFGMSRDVYSTDYYRLQE 547
Score = 105 bits (253), Expect = 3e-21
Identities = 45/99 (45%), Positives = 63/99 (63%)
Query: 530 HDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENV 589
H +P+RWMP ESI+Y K+T ESDVW+ GV LWEIF++ QP++ +++ EV+ + V
Sbjct: 586 HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV 645
Query: 590 LACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNI 628
L P P+ VYDLM CW P R N + I+ L N+
Sbjct: 646 LQRPRTCPKEVYDLMLGCWQREPHMRLNIKEIHGLLLNL 684
>UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF15074,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 654
Score = 158 bits (383), Expect = 5e-37
Identities = 98/307 (31%), Positives = 153/307 (49%), Gaps = 14/307 (4%)
Query: 321 KLPSNLAYHTTGAQLNPKLEKLEFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLV 380
++ N T + +++ L R+ + L +G FG++F + V
Sbjct: 349 RIEKNDLRSVTLLEAKARVKDLSVSRDRVTLGDVLQEGTFGQIFHGVLLDEKDPSKEKQV 408
Query: 381 AVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIG--RPMCLLFEYMGKGDLN 438
VK +KD AS E+ L H N++ + VC +PM LL ++ G+L
Sbjct: 409 FVKTVKDHASEVQVTMMLTESLKLRGLHHRNLLPISHVCTEDGEKPMVLL-PFVAWGNLK 467
Query: 439 EYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATR 498
+LR C + P +A QIA GM YLS R+ +H+DLA R
Sbjct: 468 LFLRQCKLAEANNP-----------QSVSQQDLVSMAIQIACGMSYLSRREVIHKDLAAR 516
Query: 499 NCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYG 558
NC+I+D M VKI+D L+ ++ DY+ +++ PVRWM LES+L+N ++ SDVWA+G
Sbjct: 517 NCVIDDSMQVKISDNALARDLFPMDYHCLGDNENRPVRWMALESLLHNDFSSLSDVWAFG 576
Query: 559 VCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNF 618
V LWE+ + PY + E+ +LKD +A P N P ++ +M CW +P +RP F
Sbjct: 577 VTLWELMTLGQTPYVDIDPFEMSAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKF 636
Query: 619 RVIYQTL 625
+ + Q L
Sbjct: 637 QQLVQCL 643
>UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2;
Schistosoma|Rep: Insulin receptor protein kinase -
Schistosoma mansoni (Blood fluke)
Length = 1499
Score = 157 bits (382), Expect = 6e-37
Identities = 94/252 (37%), Positives = 133/252 (52%), Gaps = 18/252 (7%)
Query: 380 VAVKMLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMC---LLFEYMGKGD 436
VAVK L ++ D +F EA + + IV+ LG+ A+ +P ++ EYM GD
Sbjct: 1250 VAVKTLFPASTMDDIREFYNEASFMKQLNCMYIVQFLGI-ALRQPSSHPVIIMEYMAFGD 1308
Query: 437 LNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLA 496
L YLR + A Q+A+GM YL++ +HRDLA
Sbjct: 1309 LATYLR-----------QQMSKDDCPQGSIDTQLAINWAIQLATGMNYLAELHIIHRDLA 1357
Query: 497 TRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWA 556
RNCL+N + VKIADFGL+ + Q+YY+ +PVRWM E++ +T +SDVW+
Sbjct: 1358 ARNCLVNSMLTVKIADFGLARLVNNQEYYRKIGQARLPVRWMAPETLSSAYFTTKSDVWS 1417
Query: 557 YGVCLWEIFSFALQPYFGMTHEEVVRFLKDE---NVLACPDNTPRCVYDLMKQCWNHNPS 613
YGV LWEI +FA PY G++HEEV++F+ D N+ CP P + LM CW P+
Sbjct: 1418 YGVVLWEIATFASLPYPGLSHEEVMKFVCDGGHLNLPECPTKLPVILLTLMNMCWEFEPT 1477
Query: 614 DRPNFRVIYQTL 625
+R F I L
Sbjct: 1478 NRLTFSEILSRL 1489
>UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1;
Schistosoma mansoni|Rep: Fes-like tyrosine kinase protein
- Schistosoma mansoni (Blood fluke)
Length = 1259
Score = 157 bits (382), Expect = 6e-37
Identities = 94/280 (33%), Positives = 145/280 (51%), Gaps = 28/280 (10%)
Query: 343 EFPRNNIIYIRDLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLK-DEASHDLQLDFEREA 401
E ++ ++ +GQG FG V++ G VAVK + D + DL+ F +
Sbjct: 955 ELDNRDVQLLQKIGQGNFGDVYRGVYNGCE-------VAVKTCRVDMTASDLRRKFLQGE 1007
Query: 402 CLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXX 461
+F+HPNIVKL+G+ P+ ++ EY+ G L +LR PV
Sbjct: 1008 TTALNFNHPNIVKLVGIAVQSYPIMIVMEYVPGGSLLNHLRKSKNAL---PV-------- 1056
Query: 462 XXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL 521
++ A+GM+YL R +HRDLA RNCLI+DD +KIADFG+S + ++
Sbjct: 1057 -------MKLLQMSLDAANGMMYLEARNCIHRDLAARNCLISDDGQLKIADFGMSREEHI 1109
Query: 522 QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVV 581
Y D+ IP++W E++ +YT++ DVW+YGV LWEIF+F PY ++++
Sbjct: 1110 --YELSDKRGQIPIKWTAPEALRTGRYTIKCDVWSYGVLLWEIFTFGDVPYRNWSNQQTR 1167
Query: 582 RFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVI 621
++ L PD P + LM CW+ P +RP+F I
Sbjct: 1168 DMIESGYRLPAPDLMPVWLRTLMNHCWHDEPMNRPSFSKI 1207
>UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Danio
rerio|Rep: Spleen protein tyrosine kinase - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 586
Score = 157 bits (381), Expect = 8e-37
Identities = 91/270 (33%), Positives = 147/270 (54%), Gaps = 25/270 (9%)
Query: 354 DLGQGAFGRVFQAKAPGLIPDEEFTLVAVKMLK-DEASHDLQLDFEREACLLADFDHPNI 412
+LG G FG V + + +VAVK+LK D+ + ++ + REA ++ D+P I
Sbjct: 327 ELGSGNFGTVLRGVYQ---MKKTQKVVAVKILKNDDDNAAVKDEMLREANVMQQLDNPYI 383
Query: 413 VKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREXXXXXXXXXXXXXXX 472
V+++G+C M L+ E G L+++L+ +T E
Sbjct: 384 VRMIGICEAENLM-LVMELAELGPLHKFLQKNKHITVKNLTE------------------ 424
Query: 473 XIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYL-QDYYKGDEHD 531
+ Q++ GM YL + FVHRDLA RN L+ KI+DFGLS + ++YYK H
Sbjct: 425 -LVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHG 483
Query: 532 AIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLA 591
P++W E + Y K++ +SDVW++GV +WE FS+ +PY GM EV++ +++ ++
Sbjct: 484 KWPLKWYAPECMNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMS 543
Query: 592 CPDNTPRCVYDLMKQCWNHNPSDRPNFRVI 621
P + P +YDLMK+CW + P +RP F V+
Sbjct: 544 APPDCPPEMYDLMKKCWTYKPDERPGFSVV 573
>UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 903
Score = 157 bits (381), Expect = 8e-37
Identities = 102/301 (33%), Positives = 148/301 (49%), Gaps = 26/301 (8%)
Query: 343 EFPRNNIIYIRD--LGQGAFGRVFQAKAPGL--------------IPDEEFTLVAVKMLK 386
E R N+I D LG GAFG V+ K G + E VAVKML
Sbjct: 535 EIERRNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANSPLGINLMRAENCQVAVKMLP 594
Query: 387 DEASHDLQLDFEREACLLADFD-HPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRA-C 444
+ A + +F RE L+ H +V +L P+CL+ EY GDL ++LR C
Sbjct: 595 EYADEMSKHEFLREIALMKTLGYHERLVNMLACVTESEPLCLVVEYCDNGDLLKFLRERC 654
Query: 445 STVTSFAPVE---H---REXXXXXXXXXXXXXXXXIARQIASGMLYLSDRKFVHRDLATR 498
+ + H A QI+ G+ YLS + FVHRD+A R
Sbjct: 655 KYMMKLDDLGINYHDPPENENYDTNMIVTLKQLLQFAVQISYGLEYLSQKGFVHRDVAAR 714
Query: 499 NCLINDDMVVKIADFGLSHKIYL-QDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAY 557
N L+++ KI DFGL IY Q YK + +P++WM E+I + +++++SD+W++
Sbjct: 715 NVLVHEGTACKIGDFGLCRYIYADQSQYKS-KGGKLPLKWMSPEAIRHYEFSIKSDIWSF 773
Query: 558 GVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPN 617
G+ L+E+ + PY GM E+V+ FL+ + PDN P YD+M QCWN +P DR
Sbjct: 774 GILLFEVITLGGSPYPGMPPEDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPDDRIE 833
Query: 618 F 618
F
Sbjct: 834 F 834
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.323 0.139 0.448
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 740,387,916
Number of Sequences: 1657284
Number of extensions: 32145251
Number of successful extensions: 79659
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 3984
Number of HSP's successfully gapped in prelim test: 3409
Number of HSP's that attempted gapping in prelim test: 64257
Number of HSP's gapped (non-prelim): 13854
length of query: 638
length of database: 575,637,011
effective HSP length: 105
effective length of query: 533
effective length of database: 401,622,191
effective search space: 214064627803
effective search space used: 214064627803
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 76 (34.7 bits)
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