Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000222-TA|BGIBMGA000222-PA|IPR006603|Cystinosin/ERS1p
repeat, IPR005282|Lysosomal cystine transporter
(566 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Y15924-1|CAA75882.1| 367|Homo sapiens cystinosin protein. 302 2e-81
BC032850-1|AAH32850.1| 400|Homo sapiens cystinosis, nephropathi... 302 2e-81
AJ222967-1|CAA11021.1| 367|Homo sapiens cystinosin protein. 302 2e-81
AF168787-2|AAF43102.1| 367|Homo sapiens CTNS protein. 302 2e-81
CR542058-1|CAG46855.1| 367|Homo sapiens CTNS protein. 297 5e-80
AF112442-1|AAD45630.1| 140|Homo sapiens nephropathic cystinosis... 155 4e-37
AK172745-1|BAD18732.1| 180|Homo sapiens protein ( Homo sapiens ... 44 0.002
BC015324-1|AAH15324.1| 226|Homo sapiens PQ loop repeat containi... 42 0.008
AL035413-7|CAI22229.1| 291|Homo sapiens PQ loop repeat containi... 42 0.008
AL035413-3|CAM12847.1| 226|Homo sapiens PQ loop repeat containi... 42 0.008
AK130175-1|BAC85298.1| 291|Homo sapiens protein ( Homo sapiens ... 42 0.008
AK130171-1|BAC85296.1| 291|Homo sapiens protein ( Homo sapiens ... 42 0.008
AK000327-1|BAA91088.1| 226|Homo sapiens protein ( Homo sapiens ... 42 0.008
>Y15924-1|CAA75882.1| 367|Homo sapiens cystinosin protein.
Length = 367
Score = 302 bits (741), Expect = 2e-81
Identities = 136/246 (55%), Positives = 176/246 (71%)
Query: 241 LRITVMHSNEINIISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTM 300
+R V+ S+ I+II+ ++GWIYF AWS+SFYPQ+ +N++RKSV+GL+FDF+ALN+ GF
Sbjct: 113 IRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVA 172
Query: 301 YSLFNCGLYFSKEIQNEYFSRHPRGLNPVQLNDVFFSLHAAFATLITITQCFLYEREEQR 360
YS+FN GL + I+ ++ ++P G+NPV NDVFFSLHA TLI I QC LYER QR
Sbjct: 173 YSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQR 232
Query: 361 VSTVGRGILGAFSAVVIVTGSIAVVGKIEWLDWLYYCSYVKLAITLIKYVPQAYMNYKRK 420
VS G L VT +A VG I WL +L+ SY+KLA+TL+KY PQAYMN+ K
Sbjct: 233 VSWPAIGFLVLAWLFAFVTMIVAAVGVITWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYK 292
Query: 421 STVGWSIGNIFLDFVGGFLSILQMVLNAYNYNDWVSFFGDATKFGLGLFSLVFDIFFILQ 480
ST GWSIGN+ LDF GG S+LQM L +YN + W FGD TKFGLG+FS+VFD+ F +Q
Sbjct: 293 STEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQ 352
Query: 481 HYVFYR 486
H+ YR
Sbjct: 353 HFCLYR 358
>BC032850-1|AAH32850.1| 400|Homo sapiens cystinosis, nephropathic
protein.
Length = 400
Score = 302 bits (741), Expect = 2e-81
Identities = 136/246 (55%), Positives = 176/246 (71%)
Query: 241 LRITVMHSNEINIISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTM 300
+R V+ S+ I+II+ ++GWIYF AWS+SFYPQ+ +N++RKSV+GL+FDF+ALN+ GF
Sbjct: 113 IRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVA 172
Query: 301 YSLFNCGLYFSKEIQNEYFSRHPRGLNPVQLNDVFFSLHAAFATLITITQCFLYEREEQR 360
YS+FN GL + I+ ++ ++P G+NPV NDVFFSLHA TLI I QC LYER QR
Sbjct: 173 YSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQR 232
Query: 361 VSTVGRGILGAFSAVVIVTGSIAVVGKIEWLDWLYYCSYVKLAITLIKYVPQAYMNYKRK 420
VS G L VT +A VG I WL +L+ SY+KLA+TL+KY PQAYMN+ K
Sbjct: 233 VSWPAIGFLVLAWLFAFVTMIVAAVGVITWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYK 292
Query: 421 STVGWSIGNIFLDFVGGFLSILQMVLNAYNYNDWVSFFGDATKFGLGLFSLVFDIFFILQ 480
ST GWSIGN+ LDF GG S+LQM L +YN + W FGD TKFGLG+FS+VFD+ F +Q
Sbjct: 293 STEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQ 352
Query: 481 HYVFYR 486
H+ YR
Sbjct: 353 HFCLYR 358
>AJ222967-1|CAA11021.1| 367|Homo sapiens cystinosin protein.
Length = 367
Score = 302 bits (741), Expect = 2e-81
Identities = 136/246 (55%), Positives = 176/246 (71%)
Query: 241 LRITVMHSNEINIISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTM 300
+R V+ S+ I+II+ ++GWIYF AWS+SFYPQ+ +N++RKSV+GL+FDF+ALN+ GF
Sbjct: 113 IRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVA 172
Query: 301 YSLFNCGLYFSKEIQNEYFSRHPRGLNPVQLNDVFFSLHAAFATLITITQCFLYEREEQR 360
YS+FN GL + I+ ++ ++P G+NPV NDVFFSLHA TLI I QC LYER QR
Sbjct: 173 YSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQR 232
Query: 361 VSTVGRGILGAFSAVVIVTGSIAVVGKIEWLDWLYYCSYVKLAITLIKYVPQAYMNYKRK 420
VS G L VT +A VG I WL +L+ SY+KLA+TL+KY PQAYMN+ K
Sbjct: 233 VSWPAIGFLVLAWLFAFVTMIVAAVGVITWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYK 292
Query: 421 STVGWSIGNIFLDFVGGFLSILQMVLNAYNYNDWVSFFGDATKFGLGLFSLVFDIFFILQ 480
ST GWSIGN+ LDF GG S+LQM L +YN + W FGD TKFGLG+FS+VFD+ F +Q
Sbjct: 293 STEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQ 352
Query: 481 HYVFYR 486
H+ YR
Sbjct: 353 HFCLYR 358
>AF168787-2|AAF43102.1| 367|Homo sapiens CTNS protein.
Length = 367
Score = 302 bits (741), Expect = 2e-81
Identities = 136/246 (55%), Positives = 176/246 (71%)
Query: 241 LRITVMHSNEINIISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTM 300
+R V+ S+ I+II+ ++GWIYF AWS+SFYPQ+ +N++RKSV+GL+FDF+ALN+ GF
Sbjct: 113 IRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVA 172
Query: 301 YSLFNCGLYFSKEIQNEYFSRHPRGLNPVQLNDVFFSLHAAFATLITITQCFLYEREEQR 360
YS+FN GL + I+ ++ ++P G+NPV NDVFFSLHA TLI I QC LYER QR
Sbjct: 173 YSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQR 232
Query: 361 VSTVGRGILGAFSAVVIVTGSIAVVGKIEWLDWLYYCSYVKLAITLIKYVPQAYMNYKRK 420
VS G L VT +A VG I WL +L+ SY+KLA+TL+KY PQAYMN+ K
Sbjct: 233 VSWPAIGFLVLAWLFAFVTMIVAAVGVITWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYK 292
Query: 421 STVGWSIGNIFLDFVGGFLSILQMVLNAYNYNDWVSFFGDATKFGLGLFSLVFDIFFILQ 480
ST GWSIGN+ LDF GG S+LQM L +YN + W FGD TKFGLG+FS+VFD+ F +Q
Sbjct: 293 STEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQ 352
Query: 481 HYVFYR 486
H+ YR
Sbjct: 353 HFCLYR 358
>CR542058-1|CAG46855.1| 367|Homo sapiens CTNS protein.
Length = 367
Score = 297 bits (730), Expect = 5e-80
Identities = 134/246 (54%), Positives = 174/246 (70%)
Query: 241 LRITVMHSNEINIISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTM 300
+R V+ S+ I+II+ ++GWIYF AWS+SFYPQ+ +N++RKSV+GL+FDF+ALN+ GF
Sbjct: 113 IRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVA 172
Query: 301 YSLFNCGLYFSKEIQNEYFSRHPRGLNPVQLNDVFFSLHAAFATLITITQCFLYEREEQR 360
YS+FN GL + I+ ++ ++P G+NPV NDVFFSLHA TLI I QC LYER Q
Sbjct: 173 YSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQS 232
Query: 361 VSTVGRGILGAFSAVVIVTGSIAVVGKIEWLDWLYYCSYVKLAITLIKYVPQAYMNYKRK 420
VS G L VT +A VG WL +L+ SY+KLA+TL+KY PQAYMN+ K
Sbjct: 233 VSWPAIGFLVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYK 292
Query: 421 STVGWSIGNIFLDFVGGFLSILQMVLNAYNYNDWVSFFGDATKFGLGLFSLVFDIFFILQ 480
ST GWSIGN+ LDF GG S+LQM L +YN + W FGD TKFGLG+FS+VFD+ F +Q
Sbjct: 293 STEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQ 352
Query: 481 HYVFYR 486
H+ YR
Sbjct: 353 HFCLYR 358
>AF112442-1|AAD45630.1| 140|Homo sapiens nephropathic cystinosis
protein.
Length = 140
Score = 155 bits (376), Expect = 4e-37
Identities = 72/131 (54%), Positives = 88/131 (67%)
Query: 356 REEQRVSTVGRGILGAFSAVVIVTGSIAVVGKIEWLDWLYYCSYVKLAITLIKYVPQAYM 415
R QRVS G L VT +A VG I WL +L+ SY+KLA+TL+KY PQAYM
Sbjct: 1 RGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGVITWLQFLFCFSYIKLAVTLVKYFPQAYM 60
Query: 416 NYKRKSTVGWSIGNIFLDFVGGFLSILQMVLNAYNYNDWVSFFGDATKFGLGLFSLVFDI 475
N+ KST GWSIGN+ LDF GG S+LQM L +YN + W FGD TKFGLG+FS+VFD+
Sbjct: 61 NFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDV 120
Query: 476 FFILQHYVFYR 486
F +QH+ YR
Sbjct: 121 VFFIQHFCLYR 131
>AK172745-1|BAD18732.1| 180|Homo sapiens protein ( Homo sapiens
cDNA FLJ23906 fis, clone ADSE01759. ).
Length = 180
Score = 43.6 bits (98), Expect = 0.002
Identities = 19/51 (37%), Positives = 32/51 (62%)
Query: 253 IISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTMYSL 303
+I +++G I+ + +S PQI NF RKS G+++ AL ++G T+Y L
Sbjct: 71 VIGFVIGSIFSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 121
>BC015324-1|AAH15324.1| 226|Homo sapiens PQ loop repeat containing
2 protein.
Length = 226
Score = 41.5 bits (93), Expect = 0.008
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 253 IISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTMYSL 303
+I +++G I + +S PQI NF RKS G+++ AL ++G T+Y L
Sbjct: 117 VIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 167
>AL035413-7|CAI22229.1| 291|Homo sapiens PQ loop repeat containing
2 protein.
Length = 291
Score = 41.5 bits (93), Expect = 0.008
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 253 IISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTMYSL 303
+I +++G I + +S PQI NF RKS G+++ AL ++G T+Y L
Sbjct: 182 VIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 232
>AL035413-3|CAM12847.1| 226|Homo sapiens PQ loop repeat containing
2 protein.
Length = 226
Score = 41.5 bits (93), Expect = 0.008
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 253 IISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTMYSL 303
+I +++G I + +S PQI NF RKS G+++ AL ++G T+Y L
Sbjct: 117 VIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 167
>AK130175-1|BAC85298.1| 291|Homo sapiens protein ( Homo sapiens
cDNA FLJ26665 fis, clone MPG02687. ).
Length = 291
Score = 41.5 bits (93), Expect = 0.008
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 253 IISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTMYSL 303
+I +++G I + +S PQI NF RKS G+++ AL ++G T+Y L
Sbjct: 182 VIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 232
>AK130171-1|BAC85296.1| 291|Homo sapiens protein ( Homo sapiens
cDNA FLJ26661 fis, clone MPG01974. ).
Length = 291
Score = 41.5 bits (93), Expect = 0.008
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 253 IISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTMYSL 303
+I +++G I + +S PQI NF RKS G+++ AL ++G T+Y L
Sbjct: 182 VIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 232
>AK000327-1|BAA91088.1| 226|Homo sapiens protein ( Homo sapiens
cDNA FLJ20320 fis, clone HEP08923. ).
Length = 226
Score = 41.5 bits (93), Expect = 0.008
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 253 IISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTMYSL 303
+I +++G I + +S PQI NF RKS G+++ AL ++G T+Y L
Sbjct: 117 VIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGL 167
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.325 0.139 0.432
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 83,105,741
Number of Sequences: 224733
Number of extensions: 3459652
Number of successful extensions: 11276
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 11245
Number of HSP's gapped (non-prelim): 21
length of query: 566
length of database: 73,234,838
effective HSP length: 94
effective length of query: 472
effective length of database: 52,109,936
effective search space: 24595889792
effective search space used: 24595889792
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.6 bits)
S2: 68 (31.5 bits)
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