Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000197-TA|BGIBMGA000197-PA|IPR003754|Uroporphyrinogen
III synthase HEM4
(248 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q7Q3V6 Cluster: ENSANGP00000011555; n=2; Culicidae|Rep:... 129 6e-29
UniRef50_P10746 Cluster: Uroporphyrinogen-III synthase; n=23; Th... 124 2e-27
UniRef50_UPI0000D56F5B Cluster: PREDICTED: similar to CG1885-PA;... 119 6e-26
UniRef50_UPI00015B5CA2 Cluster: PREDICTED: similar to ENSANGP000... 118 1e-25
UniRef50_Q1ET39 Cluster: Uroporphyrinogen III synthase; n=12; Eu... 111 2e-23
UniRef50_Q9W3B3 Cluster: CG1885-PA; n=2; Sophophora|Rep: CG1885-... 109 5e-23
UniRef50_A7RZ79 Cluster: Predicted protein; n=1; Nematostella ve... 109 5e-23
UniRef50_UPI00003C04D4 Cluster: PREDICTED: similar to uroporphyr... 97 4e-19
UniRef50_Q5PPR7 Cluster: LOC496102 protein; n=2; Xenopus|Rep: LO... 93 8e-18
UniRef50_UPI0000E48EE2 Cluster: PREDICTED: similar to uroporphyr... 92 1e-17
UniRef50_Q5DB19 Cluster: SJCHGC05188 protein; n=1; Schistosoma j... 85 2e-15
UniRef50_Q9VF38 Cluster: CG9589-PA; n=3; Sophophora|Rep: CG9589-... 84 4e-15
UniRef50_UPI0000F1D40B Cluster: PREDICTED: similar to uroporphyr... 83 8e-15
UniRef50_Q2S2A7 Cluster: Uroporphyrinogen-III synthase; n=1; Sal... 76 1e-12
UniRef50_Q6FKJ8 Cluster: Candida glabrata strain CBS138 chromoso... 72 1e-11
UniRef50_Q6C2A4 Cluster: Yarrowia lipolytica chromosome F of str... 71 3e-11
UniRef50_A3J3E7 Cluster: Uroporphyrinogen-III synthase; n=1; Fla... 70 5e-11
UniRef50_P06174 Cluster: Uroporphyrinogen-III synthase; n=4; Sac... 64 4e-09
UniRef50_Q86ZK7 Cluster: Similar to Uroporphyrinogen-III synthas... 61 3e-08
UniRef50_Q5K9B7 Cluster: Uroporphyrinogen-III synthase, putative... 60 5e-08
UniRef50_A3LW75 Cluster: Uroporphyrinogen-III synthase; n=2; Pic... 60 7e-08
UniRef50_A5FLE6 Cluster: Uroporphyrinogen III synthase HEM4; n=2... 59 9e-08
UniRef50_Q6BQF3 Cluster: Similar to CA0849|CaHEM4 Candida albica... 59 9e-08
UniRef50_A6ELI7 Cluster: DNA methylase, putative; n=1; unidentif... 57 4e-07
UniRef50_P87214 Cluster: Uroporphyrinogen-III synthase; n=1; Sch... 57 4e-07
UniRef50_UPI00015BCF14 Cluster: UPI00015BCF14 related cluster; n... 56 6e-07
UniRef50_A4BYX0 Cluster: Porphobilinogen deaminase HemC; n=11; B... 54 3e-06
UniRef50_A0M6C3 Cluster: Uroporphyrinogen-III synthase; n=1; Gra... 54 4e-06
UniRef50_Q9K8G1 Cluster: Uroporphyrinogen III cosynthase; n=1; B... 53 6e-06
UniRef50_Q5KWK7 Cluster: Uroporphyrinogen III cosynthase; n=2; G... 49 1e-04
UniRef50_Q8Y6X6 Cluster: Lmo1555 protein; n=13; Listeria|Rep: Lm... 49 1e-04
UniRef50_A2TR69 Cluster: Uroporphyrinogen-III synthetase; n=1; D... 46 9e-04
UniRef50_Q59Y07 Cluster: Potential uroporphyrinogen-III synthase... 45 0.002
UniRef50_Q54NS4 Cluster: Putative uroporphyrinogen III synthase;... 45 0.002
UniRef50_Q756B6 Cluster: AER351Wp; n=1; Eremothecium gossypii|Re... 44 0.005
UniRef50_Q58401 Cluster: Putative uroporphyrinogen-III synthase;... 44 0.005
UniRef50_A6S7S1 Cluster: Putative uncharacterized protein; n=4; ... 43 0.006
UniRef50_A4CHM2 Cluster: Uroporphyrinogen-III synthase; n=1; Rob... 43 0.008
UniRef50_A3XGZ5 Cluster: DNA methylase, putative; n=1; Leeuwenho... 43 0.008
UniRef50_Q81LC8 Cluster: Uroporphyrinogen-III synthase; n=10; Ba... 42 0.011
UniRef50_Q1INI7 Cluster: Uroporphyrinogen III synthase HEM4; n=1... 42 0.011
UniRef50_A0GXZ0 Cluster: Uroporphyrinogen III synthase HEM4; n=2... 42 0.011
UniRef50_A2U8Q2 Cluster: Uroporphyrinogen III synthase HEM4; n=1... 42 0.014
UniRef50_A5UU38 Cluster: Uroporphyrinogen III synthase HEM4; n=2... 40 0.058
UniRef50_Q8KCJ3 Cluster: Uroporphyrinogen-III synthase; n=11; Ch... 40 0.058
UniRef50_A0L5L4 Cluster: Uroporphyrinogen III synthase HEM4; n=1... 40 0.077
UniRef50_A3U6E9 Cluster: Uroporphyrinogen-III synthase; n=1; Cro... 39 0.10
UniRef50_Q3ACT2 Cluster: Uroporphyrinogen-III synthase; n=1; Car... 39 0.14
UniRef50_Q1D8Z7 Cluster: Uroporphyrinogen-III synthase; n=2; Cys... 39 0.14
UniRef50_Q5SI67 Cluster: Probable uroporphyrinogen III synthase;... 38 0.24
UniRef50_Q4AGE3 Cluster: Uroporphyrinogen III synthase HEM4; n=1... 38 0.24
UniRef50_A0JYM5 Cluster: Uroporphyrinogen III synthase HEM4; n=1... 38 0.24
UniRef50_Q26GL2 Cluster: Putative uncharacterized protein; n=1; ... 38 0.31
UniRef50_A6DQN2 Cluster: Uroporphyrinogen-III synthetase; n=1; L... 37 0.41
UniRef50_A3ETN4 Cluster: Uroporphyrinogen-III methylase; n=1; Le... 37 0.41
UniRef50_Q8EPM9 Cluster: Uroporphyrinogen-III synthase; n=1; Oce... 37 0.55
UniRef50_Q4HTB5 Cluster: Uroporphyrinogen-III synthase; n=10; Ca... 37 0.55
UniRef50_Q30XG4 Cluster: Uroporphyrin-III C-methyltransferase; n... 36 0.72
UniRef50_A0NYU7 Cluster: Putative uroporphyrinogen III synthase;... 36 0.95
UniRef50_A0CMJ6 Cluster: Chromosome undetermined scaffold_21, wh... 36 1.3
UniRef50_Q59294 Cluster: Porphyrin biosynthesis protein hemD [In... 36 1.3
UniRef50_Q8TV50 Cluster: Uroporphyrinogen-III synthase; n=1; Met... 35 1.7
UniRef50_Q11DF2 Cluster: Uroporphyrinogen III synthase HEM4; n=1... 35 2.2
UniRef50_Q0EVH9 Cluster: Uroporphyrin-III C-methyltransferase; n... 34 2.9
UniRef50_Q0UYR9 Cluster: Putative uncharacterized protein; n=2; ... 34 2.9
UniRef50_Q24N38 Cluster: Putative anaerobic dehydrogenase; n=1; ... 34 3.8
UniRef50_A6DCE0 Cluster: Uroporphyrinogen-III synthetase; n=1; C... 34 3.8
UniRef50_Q2B6K9 Cluster: Uroporphyrinogen-III synthetase; n=1; B... 33 5.1
UniRef50_Q1YDX2 Cluster: Putative uroporphyrinogen-III synthase;... 33 5.1
UniRef50_Q8XKG5 Cluster: Uroporphyrinogen III methylase; n=12; C... 33 6.7
UniRef50_A4SX03 Cluster: FAD-dependent pyridine nucleotide-disul... 33 6.7
UniRef50_Q943R3 Cluster: Calmodulin-binding protein-like; n=2; O... 33 6.7
UniRef50_Q86EY4 Cluster: Clone ZZD1296 mRNA sequence; n=1; Schis... 33 6.7
UniRef50_A2FEK1 Cluster: Putative uncharacterized protein; n=1; ... 33 6.7
UniRef50_A7DLH1 Cluster: Uroporphyrinogen-III synthase; n=2; Met... 33 8.9
UniRef50_A3V904 Cluster: Phage integrase; n=4; Loktanella vestfo... 33 8.9
UniRef50_Q82DM5 Cluster: Adenylate kinase; n=8; Bacteria|Rep: Ad... 33 8.9
>UniRef50_Q7Q3V6 Cluster: ENSANGP00000011555; n=2; Culicidae|Rep:
ENSANGP00000011555 - Anopheles gambiae str. PEST
Length = 257
Score = 129 bits (312), Expect = 6e-29
Identities = 82/248 (33%), Positives = 126/248 (50%), Gaps = 10/248 (4%)
Query: 3 IVLFKGESED---YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQN-DYDGMILTSPR 58
+V+ K ESE+ Y + ++ +E +F+ L F + N++ L +LL Y G+I TSPR
Sbjct: 9 VVILKSESENADNYGTLLEKHGYEPVFIPTLDFSFKNLDVLRDRLLSPYKYSGLIFTSPR 68
Query: 59 AVEAVSKCWDPTKFVI--WNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILK 116
++ AV + + + W + D Y+VGE S + I+ NA NL+ I
Sbjct: 69 SITAVRDALEGQRKLKDDWKTLDNYSVGETSRELIQRTLDLDTKGQHSGNASNLADFIKT 128
Query: 117 D---KKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLND 173
D K T FLFPCGNL+ + + N L G +LD++ VYET + +L+ L E +
Sbjct: 129 DLYNKTITMPFLFPCGNLKQDVLQNKLSEYGYSLDSVEVYETVPHRDLERNLREKEG-DR 187
Query: 174 SPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAE 233
+ L FFSPSG Y + L+ AIG ST IEN G+ + A KP +
Sbjct: 188 TIDSLLFFSPSGINYCAHVFEKHRIDLTGKRIIAIGPSTKKAIENKGITVHRTAEKPSPD 247
Query: 234 SLVESVLK 241
+V ++L+
Sbjct: 248 YVVGALLQ 255
>UniRef50_P10746 Cluster: Uroporphyrinogen-III synthase; n=23;
Theria|Rep: Uroporphyrinogen-III synthase - Homo sapiens
(Human)
Length = 265
Score = 124 bits (300), Expect = 2e-27
Identities = 78/258 (30%), Positives = 123/258 (47%), Gaps = 18/258 (6%)
Query: 1 MKIVLFKGESED------YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMI 53
MK++L K ED Y R E + L F ++++ S+KL DY G+I
Sbjct: 1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 60
Query: 54 LTSPRAVEAVSKC---------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXX 104
TSPRAVEA C W+ + WN+K VY VG ++ +
Sbjct: 61 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 120
Query: 105 XNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKAL 164
NAE L++ I + LFPCGNL+ E +P L+ +GI +++ITVY+T + ++
Sbjct: 121 -NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGN 179
Query: 165 LMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFS-NRLSLLPHFAIGNSTAHKIENLGVEI 223
L + P+ + FFSPSG Y + +Q S + + + AIG +TA + G+ +
Sbjct: 180 LNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPV 239
Query: 224 AGVAAKPKAESLVESVLK 241
+ A P ++L + K
Sbjct: 240 SCTAESPTPQALATGIRK 257
>UniRef50_UPI0000D56F5B Cluster: PREDICTED: similar to CG1885-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG1885-PA - Tribolium castaneum
Length = 250
Score = 119 bits (287), Expect = 6e-26
Identities = 76/245 (31%), Positives = 131/245 (53%), Gaps = 11/245 (4%)
Query: 3 IVLFKGESED--YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQND-YDGMILTSPRA 59
++L K ++ D Y ++ + NF+ + V+ L F Y N L +KLL D Y G++L+SPR
Sbjct: 8 VLLLKSDTTDDKYTKLLQARNFKVMAVKTLVFEYKNAAILREKLLSADKYSGILLSSPRC 67
Query: 60 VEAVSKCWDPTKFV-IWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDK 118
V AVS+ + +W K YTVGE + ++ NA+NL+++I++ K
Sbjct: 68 VSAVSQALEKRLVQELWGPKSNYTVGESTYKEALDKLGVECQGKESGNAKNLAQLIIQSK 127
Query: 119 KK-TSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLME-LNNLNDSPS 176
+ T FLFP GNL+++T+ L E + ++ + VY+T N ++ L E NN D P
Sbjct: 128 AQFTKPFLFPHGNLKTDTLKLELGRENLQIEGVLVYDTLPNPDIAQELSECTNNFTDIPE 187
Query: 177 GLAFFSPSGCEYIHRQLQTFSNRLS--LLPHFAIGNSTAHKIENLGVEIAGVAAKPKAES 234
+ +FSPSG +H ++ L+ + AIG T +++L + + VA P E
Sbjct: 188 FVIYFSPSG---LHSSIEYLRKLLTDRGVKIIAIGPVTELALQDLNLTVHAVAKSPTPEE 244
Query: 235 LVESV 239
+++++
Sbjct: 245 VIKTL 249
>UniRef50_UPI00015B5CA2 Cluster: PREDICTED: similar to
ENSANGP00000011555; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000011555 - Nasonia
vitripennis
Length = 259
Score = 118 bits (284), Expect = 1e-25
Identities = 77/238 (32%), Positives = 121/238 (50%), Gaps = 14/238 (5%)
Query: 13 YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQND-YDGMILTSPRAVEAVS--KCWDP 69
Y++ E+ FE ++ L F +IN+++L LL ++ Y+G+ILTSPRA A++ K +P
Sbjct: 25 YKKCLTEHGFECEILQVLHFEFINLDDLRNTLLDSESYNGLILTSPRAAAAIAMTKMQNP 84
Query: 70 TKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXX-NAENLSKIILKDKKKT--STFLF 126
W K + +G+ + K NA+NL+ I+ K+ L
Sbjct: 85 FSLEPWLEKTTFCIGQATEFVAKEQVGLTNIFGSDSGNAKNLANFIVHTMKEKCKKPLLL 144
Query: 127 PCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGC 186
PC ++ +TIP +L + I + I VY+T+ + L L E LN SP L F+SPS
Sbjct: 145 PCSDIARDTIPQILLNNKIEVKKIVVYKTKAHHFLAEALNEA--LNQSPHVLVFYSPS-- 200
Query: 187 EYIHRQLQTFSNRLSLLPHF---AIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLK 241
+ L SN ++ +F AIG T +EN G+++ GVA KP+ SL E + K
Sbjct: 201 -IVDNMLNALSNNKTIFENFKIIAIGPVTEEALENAGIKVDGVAEKPEPTSLTEVIQK 257
>UniRef50_Q1ET39 Cluster: Uroporphyrinogen III synthase; n=12;
Euteleostomi|Rep: Uroporphyrinogen III synthase - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 262
Score = 111 bits (266), Expect = 2e-23
Identities = 74/257 (28%), Positives = 130/257 (50%), Gaps = 20/257 (7%)
Query: 1 MKIVLFK------GESEDYQRIFRENNFETIFVEPLQFIYINIEELSQKLLQND-YDGMI 53
MK++L K E++ Y + + L F ++++ ELS++L Q + + G+I
Sbjct: 1 MKVLLLKEPRESESEADPYIKELASCGHTATLIPALSFRFVSLNELSERLFQPERFGGLI 60
Query: 54 LTSPRAVEAVS---------KCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXX 104
TSPRAVEAV + WD K WN+K VY VG+ ++ +
Sbjct: 61 FTSPRAVEAVKTSLESQKLRRKWDAVKDK-WNTKSVYVVGKATASLV-VDLGLRPLGEDS 118
Query: 105 XNAENLSKIIL-KDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKA 163
A+ L+ +IL ++ FPCG+++ E +P L++ I L+ +TVY+T E+ +L+
Sbjct: 119 GTADALTLLILQRENPDIEPLFFPCGSIKREVLPTALRNSHIPLETLTVYQTSEHPDLQK 178
Query: 164 LLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSN-RLSLLPHFAIGNSTAHKIENLGVE 222
+ + P+ +AFFSPSG + L+ S +L + +IG +TA ++ G+
Sbjct: 179 NISDYFTQQGVPACVAFFSPSGVSFCLDLLKDLSGCQLEQIKFASIGRTTADALQARGLT 238
Query: 223 IAGVAAKPKAESLVESV 239
++ A KP A+ L ++
Sbjct: 239 VSCCAEKPTAKHLAIAI 255
>UniRef50_Q9W3B3 Cluster: CG1885-PA; n=2; Sophophora|Rep: CG1885-PA
- Drosophila melanogaster (Fruit fly)
Length = 277
Score = 109 bits (263), Expect = 5e-23
Identities = 79/247 (31%), Positives = 119/247 (48%), Gaps = 9/247 (3%)
Query: 3 IVLFKGESED---YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQND-YDGMILTSPR 58
+++FK ESE Y +++F +FV L F + N++EL KL D Y G+I TSPR
Sbjct: 8 VIIFKSESESSDVYAETLEKHDFNPVFVPTLSFGFKNLDELRAKLQNPDKYAGIIFTSPR 67
Query: 59 AVEAVSKCWDPTKFVI-WNSKDVYTVGEMSSQ-KIKXXXXXXXXXXXXXNAENLSKIILK 116
VEAV++ + + W Y VGE++ + NA L I+
Sbjct: 68 CVEAVAESLNLGELPGGWKMLHNYAVGEVTHNLALSTLDQLFTHGKQTGNARALGDYIVD 127
Query: 117 --DKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKA-LLMELNNLND 173
D + L PCGNL ++T+ + L G ++DA VYET+ + L A + L +
Sbjct: 128 TFDGSRALPLLLPCGNLATDTLLSKLAENGFSVDACEVYETRCHPELGANVERALEIYGE 187
Query: 174 SPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAE 233
S LAFFSPSG + + + AIG ST +E+LG ++ A +P E
Sbjct: 188 SIEFLAFFSPSGVNCAQQYFTSRQLSMDKWKLVAIGPSTRRALESLGQKVYCTAERPTVE 247
Query: 234 SLVESVL 240
LV+ +L
Sbjct: 248 HLVKVLL 254
>UniRef50_A7RZ79 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 239
Score = 109 bits (263), Expect = 5e-23
Identities = 77/248 (31%), Positives = 119/248 (47%), Gaps = 23/248 (9%)
Query: 3 IVLFKGESED-----YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMILTS 56
++L + S+D Y R + F+ + L F + N+++L + L + +Y G+ILTS
Sbjct: 8 VLLLRSSSDDPKQDRYHMELRSHGFQCTSIPVLSFEFENLDKLEKMLSEPTEYGGIILTS 67
Query: 57 PRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILK 116
R VEA+ KC + E S K +AE L+ +IL+
Sbjct: 68 ARGVEAMEKC----------------IEEKISLSAKKKLGLESVGHQAGSAEMLAPMILE 111
Query: 117 DKK-KTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSP 175
+T FLFPCGNLR ETIP +Q+ G+ L + VY+T ++ L L P
Sbjct: 112 GAHPQTKPFLFPCGNLRKETIPTEMQNAGVPLKGLQVYKTCKHTELAQNLTSHVEEKGVP 171
Query: 176 SGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESL 235
S + FFSPSG +++ L S L AIG +T+ + G+ +A VA +P +SL
Sbjct: 172 SVIVFFSPSGVQFVLSLLTEIFGDFSALKLVAIGATTSAAMIKHGLSVAAVAKQPSPKSL 231
Query: 236 VESVLKYF 243
E + + F
Sbjct: 232 AECISQCF 239
>UniRef50_UPI00003C04D4 Cluster: PREDICTED: similar to
uroporphyrinogen III synthase; n=1; Apis mellifera|Rep:
PREDICTED: similar to uroporphyrinogen III synthase -
Apis mellifera
Length = 266
Score = 97.1 bits (231), Expect = 4e-19
Identities = 73/249 (29%), Positives = 121/249 (48%), Gaps = 13/249 (5%)
Query: 2 KIVLFKGESED------YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQND-YDGMIL 54
K+VL +G SE Y + + + + L+F ++NI EL L + Y G++L
Sbjct: 7 KVVLCRGLSEKNDSQEAYVKTLKTAGYLCDCLPTLRFEFVNISELRTCFLSSSSYYGLVL 66
Query: 55 TSPRAVEAV--SKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXX-XXXXXXNAENLS 111
TS RA EA+ S DP + W + VY VG + K NA+ L+
Sbjct: 67 TSRRAAEAIELSAKEDPDILLPWKTLPVYCVGPATESFAKSHLGSENCFGKEAGNAKELA 126
Query: 112 KIILKD-KKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNN 170
++++ +KK+ L+PC + ETI L I + I VY+T ++ L+ L++
Sbjct: 127 ELLVASIEKKSKPLLYPCSEIGRETIEKTLNENDIKIHKIVVYKTLASKTLEHDLLKF-- 184
Query: 171 LNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKP 230
+++ P FFSPS EYI L+ S L+ + AIG T + + G+++ A KP
Sbjct: 185 MDNVPKIFIFFSPSTVEYIVTLLKKKSYDLNNIKAVAIGPVTRQALLDAGLKVFATANKP 244
Query: 231 KAESLVESV 239
SL++++
Sbjct: 245 DPVSLLDAI 253
>UniRef50_Q5PPR7 Cluster: LOC496102 protein; n=2; Xenopus|Rep:
LOC496102 protein - Xenopus laevis (African clawed frog)
Length = 237
Score = 92.7 bits (220), Expect = 8e-18
Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 20/233 (8%)
Query: 10 SEDYQRIFRENNFETIFVEPLQFIYINIEELSQKLLQND-YDGMILTSPRAVEAVSKCWD 68
S+ Y + + + L F +++++ KL + Y G+I TSPRAVEAV C
Sbjct: 16 SDPYVKELSLRGLQATLIPVLSFKFVSLDLFFDKLSHPESYAGLIFTSPRAVEAVKLCLQ 75
Query: 69 PTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIIL-KDKKKTSTFLFP 127
+ + + GE S NAE L+ I K + LFP
Sbjct: 76 KPDNIKVEEIGLSSEGEGSG-----------------NAEKLADCICSKGLSYAAPILFP 118
Query: 128 CGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCE 187
CG+L+ E +P L + + L+ ITVY+T + ++ LM+ P+ + FFSPSG +
Sbjct: 119 CGSLKREVLPKKLHEKNVPLETITVYQTSPHPAIQDSLMDYYTKKGVPASIVFFSPSGVK 178
Query: 188 YIHRQLQTF-SNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESV 239
Y + L+ S++L+ + AIG +TA + G+ ++ A P + L +
Sbjct: 179 YCLKFLKDLPSDQLNQIKFAAIGPTTAEAMAEEGIPVSCTAQNPTPQDLAVGI 231
>UniRef50_UPI0000E48EE2 Cluster: PREDICTED: similar to
uroporphyrinogen III synthase; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to uroporphyrinogen
III synthase - Strongylocentrotus purpuratus
Length = 313
Score = 91.9 bits (218), Expect = 1e-17
Identities = 52/135 (38%), Positives = 71/135 (52%), Gaps = 1/135 (0%)
Query: 106 NAENLSKIILKDKKKTST-FLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKAL 164
NAENL KIIL+ K S L+PCG +R ETIP LQ EGI Y+T N +L+
Sbjct: 170 NAENLCKIILEAVKPGSKPLLYPCGTMRRETIPKTLQKEGILFKEDVAYQTVPNPDLEQE 229
Query: 165 LMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIA 224
L + +P + FFSPSG +Y F L AIG +T ++ G +A
Sbjct: 230 LAKYLQEKGAPFCIVFFSPSGVQYSKEVFDKFKADLHSTKLLAIGGTTRAAMQEHGYVVA 289
Query: 225 GVAAKPKAESLVESV 239
GVA KP +L++++
Sbjct: 290 GVAEKPNPTALLQAI 304
Score = 47.2 bits (107), Expect = 4e-04
Identities = 31/117 (26%), Positives = 57/117 (48%), Gaps = 11/117 (9%)
Query: 11 EDYQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMILTSPRAVEAVSKC--- 66
+ YQ F+E + + + + P+ F +I+++ L + D+ G+I +SPR V++V+ C
Sbjct: 16 DKYQEAFQEADVDCVSLSPIGFEFIDLDTLYAHISHPEDHSGLIFSSPRTVQSVALCLER 75
Query: 67 ------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKD 117
W+ W+ ++VG S+ + NAENL KIIL++
Sbjct: 76 HDTNDEWNSRLRDEWSKLHAFSVG-TSTGGVVRKLGLHPVGEDSGNAENLCKIILEE 131
>UniRef50_Q5DB19 Cluster: SJCHGC05188 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC05188 protein - Schistosoma
japonicum (Blood fluke)
Length = 250
Score = 85.0 bits (201), Expect = 2e-15
Identities = 64/235 (27%), Positives = 107/235 (45%), Gaps = 9/235 (3%)
Query: 11 EDYQRIFRENNFETIFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPT 70
+ Y +I ++ F +E L F Y K +N++ ++ +SPRAV + K
Sbjct: 19 DPYVQILAKSGFNVNLLETLDFEYNTSNLAEYKNWRNNHSCIVFSSPRAVISYVKAG--- 75
Query: 71 KFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILK--DKKKTSTFLFPC 128
+ N D+ V S++ +A L+ ILK K FP
Sbjct: 76 --LTGNENDLCFVVGPSTELQAKKAGFSPKGSDSGDAVKLADFILKHYSSKLDKPIFFPS 133
Query: 129 GNLRSETIPNMLQSEGITLDAITVYETQENENL-KALLMELNNLNDSPSGLAFFSPSGCE 187
G + +T+P +L++ G ++ + Y + EN L + L + L N P L +FSPSG
Sbjct: 134 GQVHLDTLPKVLENAGKKVNTVVAYSSVENTQLHEKLRLNLCEGNPIPECLVYFSPSGVS 193
Query: 188 YIHRQLQT-FSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLK 241
+ L T + A+G +TA +++ LG+ I+ VA+ PK ESL+ +V K
Sbjct: 194 LTEKILITEIKPHRPNIKLVAMGRATASRLKELGLTISAVASSPKPESLLAAVQK 248
>UniRef50_Q9VF38 Cluster: CG9589-PA; n=3; Sophophora|Rep: CG9589-PA
- Drosophila melanogaster (Fruit fly)
Length = 253
Score = 83.8 bits (198), Expect = 4e-15
Identities = 65/247 (26%), Positives = 113/247 (45%), Gaps = 14/247 (5%)
Query: 3 IVLFKGESED--YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMILTSPRA 59
++L K S D Y R +N + IF+ P F++ N+++L KL + + Y G+I SPR
Sbjct: 9 VILLKVPSSDDFYGSALRSHNLDPIFITPSHFVFKNLKQLQAKLHEPHKYAGIIFASPRC 68
Query: 60 VEAVSKCWDPTKFV-IWNSKDVYTVGEMS-SQKIKXXXXXXXXXXXXXNAENLSKIILKD 117
V+AV++ T W + Y++G+ + S NA NL +I++
Sbjct: 69 VQAVNEALGKTPLPSCWRALHNYSLGKNTHSAAWITFQNLPTLGDHAVNANNLCDLIVET 128
Query: 118 --KKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSP 175
K+ L PCGN +T+ L ++G +DA VYE++ + + +
Sbjct: 129 FGPKRDLPLLMPCGNGVGQTLRLRLVAQGFRVDACEVYESRSHPDFVNQMRHALKFKRME 188
Query: 176 SGLAFFSPSGCEYIHRQLQTFSN-RLSLLPH--FAIGNSTAHKIENLGVEIAGVAAKPKA 232
+ + FF PS + L+ F N +SL A+G+ T +E G++ GV
Sbjct: 189 T-IVFFGPSS---VRSSLEFFGNYNVSLKDRKLIAVGSGTRKAMEESGIKADGVVNAADV 244
Query: 233 ESLVESV 239
+ L+ +
Sbjct: 245 DRLINII 251
>UniRef50_UPI0000F1D40B Cluster: PREDICTED: similar to
uroporphyrinogen III synthase; n=1; Danio rerio|Rep:
PREDICTED: similar to uroporphyrinogen III synthase -
Danio rerio
Length = 275
Score = 82.6 bits (195), Expect = 8e-15
Identities = 57/204 (27%), Positives = 97/204 (47%), Gaps = 19/204 (9%)
Query: 1 MKIVLFK------GESEDYQRIFRENNFETIFVEPLQFIYINIEELSQKLLQND-YDGMI 53
MK++L K E++ Y + + L F ++++ ELS++L Q + + G+I
Sbjct: 1 MKVLLLKEPRESESEADPYIKELASCGHTATLIPALSFRFVSLNELSERLFQPERFGGLI 60
Query: 54 LTSPRAVEAVSKC---------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXX 104
TSPRAVEAV WD K WN+K VY VG+ ++ +
Sbjct: 61 FTSPRAVEAVKTSLELQKLRHQWDAVKDK-WNAKSVYVVGKATASLV-VDLGLRPLGEDS 118
Query: 105 XNAENLSKIIL-KDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKA 163
A+ L+ +IL ++ FPCG+++ E +P L++ I L+ +TVY+T E+ +L+
Sbjct: 119 GTADALALLILQRENPDIEPLFFPCGSIKREVLPTALRNSHIPLETLTVYQTSEHPDLQK 178
Query: 164 LLMELNNLNDSPSGLAFFSPSGCE 187
+ + S F +G E
Sbjct: 179 NISDYFTQQRFLSKYGFIKAAGSE 202
>UniRef50_Q2S2A7 Cluster: Uroporphyrinogen-III synthase; n=1;
Salinibacter ruber DSM 13855|Rep: Uroporphyrinogen-III
synthase - Salinibacter ruber (strain DSM 13855)
Length = 262
Score = 75.8 bits (178), Expect = 1e-12
Identities = 64/232 (27%), Positives = 104/232 (44%), Gaps = 18/232 (7%)
Query: 13 YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQND-YDGMILTSPRAVEAVSKCWDPTK 71
Y+ RE + L F + +L +L D Y G++ TSPRA A+ + + +
Sbjct: 36 YRAALREAGLRAVCEPVLAFTFPRQAQLRDRLAAPDPYAGLLATSPRATVALEQVFASHE 95
Query: 72 FVI--WNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCG 129
+ W + Y VG ++ +++ A+ L+ I+KD + LF G
Sbjct: 96 ALADGWADRLAYAVGPKTAARLRALGLRARGDDTGT-ADALAARIVKDDPD-APLLFLSG 153
Query: 130 NLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYI 189
N R ET+P L++ + D + VYET +L S L FFSPSG E +
Sbjct: 154 NRRRETLPEALRAAEVRFDELVVYETHARTDLDV------PARGRASWLVFFSPSGLEAV 207
Query: 190 HRQ--LQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESV 239
R + ++RL+ AIG +TA +E G + VA +P + LV ++
Sbjct: 208 TRAEGVDVQAHRLA-----AIGPTTAEALEGDGHAVEAVADEPSPDGLVAAL 254
>UniRef50_Q6FKJ8 Cluster: Candida glabrata strain CBS138 chromosome
L complete sequence; n=1; Candida glabrata|Rep: Candida
glabrata strain CBS138 chromosome L complete sequence -
Candida glabrata (Yeast) (Torulopsis glabrata)
Length = 278
Score = 72.1 bits (169), Expect = 1e-11
Identities = 57/202 (28%), Positives = 90/202 (44%), Gaps = 10/202 (4%)
Query: 45 LQNDYDGMILTSPRAVEAVSKCWDPTKFVIWNS---KDVYTVGEMSSQKIKXXXXXXXXX 101
LQ+DYD +I+TS R++E ++ P I N K YTVG +S +
Sbjct: 70 LQDDYDFLIITSQRSIECLNL---PELKHIRNKLIDKPTYTVGPATSNFLSSLGFTDIRG 126
Query: 102 XXXX-NAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENEN 160
N L+ II D LF G +R + IP L+ T+D I +Y+T E
Sbjct: 127 GIHAGNGMKLASIIDNDYPAGGKALFLVGEIRKDIIPKYLRPRNFTVDEIIMYKTAE--- 183
Query: 161 LKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLG 220
L ++ + D + FSP G I + ++ +S IG +T + + G
Sbjct: 184 LSDSIVWFKSYLDKCDWIVVFSPQGMSDILQYMKQYSKGARPFKIACIGPTTCEFLNSNG 243
Query: 221 VEIAGVAAKPKAESLVESVLKY 242
+E V+ KP A SL+ ++ +Y
Sbjct: 244 IEPDLVSPKPDANSLIAAIKEY 265
>UniRef50_Q6C2A4 Cluster: Yarrowia lipolytica chromosome F of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome F of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 243
Score = 70.9 bits (166), Expect = 3e-11
Identities = 69/249 (27%), Positives = 114/249 (45%), Gaps = 18/249 (7%)
Query: 1 MKIVLFKGES---EDYQRIFRENN-FETIFVEPLQFIYINIEELSQKLLQNDYDGM---I 53
M I+L K + + YQ +F E +FV LQ + IE L + N+ DG+ I
Sbjct: 1 MNILLLKNPTTPRDFYQELFVEQKGHNAVFVPLLQHSPVGIESLKTHIA-NEVDGIDAVI 59
Query: 54 LTSPRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKI 113
+TS RAVE + + P K YTVG +++ ++ N L
Sbjct: 60 VTSHRAVEILGEYASPELLC----KPAYTVGPATARCLRELGFKDVRGEETGNGAALVPQ 115
Query: 114 ILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLME-LNNLN 172
+L D + F F G +R +TIPN L+ G +L TVYET + +++ + + L
Sbjct: 116 LLSDGYQR--FAFYAGKVRRDTIPNKLREAGRSLVEYTVYETVDLDDIAGRFEKAVGALP 173
Query: 173 DSP-SGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPK 231
D+ + + FF+PSG I L+ N +IG +T ++ +++ A +P
Sbjct: 174 DAKHNWICFFAPSGTAQIVEYLK--KNPAHGFKIASIGPTTLDYLQKNDIKVDVTAKQPD 231
Query: 232 AESLVESVL 240
E +E++L
Sbjct: 232 PEHFLEAML 240
>UniRef50_A3J3E7 Cluster: Uroporphyrinogen-III synthase; n=1;
Flavobacteria bacterium BAL38|Rep: Uroporphyrinogen-III
synthase - Flavobacteria bacterium BAL38
Length = 222
Score = 70.1 bits (164), Expect = 5e-11
Identities = 48/142 (33%), Positives = 79/142 (55%), Gaps = 21/142 (14%)
Query: 107 AENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLM 166
AE+L +II K K+++F+F CGN+R TIPN IT + + VYET+
Sbjct: 96 AEDLIQII-DSKYKSNSFIFFCGNIRKNTIPNYFLQNKITYNEVIVYETKPKP------- 147
Query: 167 ELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAG- 225
+ + + G+ FFSPSG ++ L+ +N L F IG +TA +EN+ E++G
Sbjct: 148 --HQVKEKFDGVLFFSPSG---VNSFLE--NNTLENKTCFCIGTTTAKTLENI-PEVSGY 199
Query: 226 ----VAAKPKAESLVESVLKYF 243
+A++P E+++ V+KY+
Sbjct: 200 KNIIIASQPTVENVINEVIKYY 221
>UniRef50_P06174 Cluster: Uroporphyrinogen-III synthase; n=4;
Saccharomycetaceae|Rep: Uroporphyrinogen-III synthase -
Saccharomyces cerevisiae (Baker's yeast)
Length = 275
Score = 63.7 bits (148), Expect = 4e-09
Identities = 70/267 (26%), Positives = 124/267 (46%), Gaps = 27/267 (10%)
Query: 1 MKIVLFKGES---EDYQRIFRENNFETIFVEPLQFIYINIEELSQKL-----LQNDYDGM 52
++++L K ++ + Y+ R FE IFV ++ ++ I++ L N + +
Sbjct: 7 VRVLLLKNKTVPIDKYELECRSKAFEPIFVPLIKHTHV-IQDFRNVLNTIPNYLNTINYI 65
Query: 53 ILTSPRAVEAVSKCWDPT----KFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXX-NA 107
I+TS R VE++++ PT + SK VYTVG ++ I+ N
Sbjct: 66 IITSQRTVESLNEAIIPTLTSEQKAALLSKTVYTVGPATANFIRRSGFINVKGGEDAGNG 125
Query: 108 ENLSKIILKDKKKT------STFLFPCGNLRSETIPNMLQSEGITLDAITVYETQE-NEN 160
L+ II+ D S LF G +R + IP L S+GI + + Y+T+E ++
Sbjct: 126 SILADIIIDDLSTDIKACPPSELLFLVGEIRRDIIPKKLHSKGIKVREVVTYKTEELSDG 185
Query: 161 LKALLMELNNLNDS---PSGLAFFSPSGCEYIHRQLQTFSNRL--SLLPHFAIGNSTAHK 215
K + + ++ + FSP G + I + L SNRL S L +IG +T
Sbjct: 186 FKRFIHAMKECDEDEVFSDWVVVFSPQGTKEITQYLGD-SNRLPGSHLRVASIGPTTKKY 244
Query: 216 IENLGVEIAGVAAKPKAESLVESVLKY 242
+++ V V+ KP +SL++++ Y
Sbjct: 245 LDDNDVTSDVVSPKPDPKSLLDAIELY 271
>UniRef50_Q86ZK7 Cluster: Similar to Uroporphyrinogen-III synthase;
n=2; Sordariales|Rep: Similar to Uroporphyrinogen-III
synthase - Podospora anserina
Length = 292
Score = 60.9 bits (141), Expect = 3e-08
Identities = 62/224 (27%), Positives = 94/224 (41%), Gaps = 28/224 (12%)
Query: 49 YDGMILTSPRAVEAVSKCWDPTK--FVIWNSKDVYTVGEMSSQKIKXXX---XXXXXXXX 103
Y GMI TS RAVEA +K + + + VY+VG +++ +K
Sbjct: 71 YGGMIFTSQRAVEAFTKLVEEGRDNWPFLQDIPVYSVGPATTRALKAVPQVPALQVFGEH 130
Query: 104 XXNAENLSKIIL-------KDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQ 156
N E L+ IL KD++ LF G+ R +TIP +L G LD + +Y T
Sbjct: 131 TGNGETLAPYILDHYRAWYKDRESVPALLFLVGDKRRDTIPEVLTGAGWQLDEVVIYGTG 190
Query: 157 ENENLK-ALLMELNNLNDSP-SGLAFFSPSGCEYIHRQLQTFS-----------NRLSLL 203
E ++ + L D P + FSPSGC+ + L NR + +
Sbjct: 191 EMKSFRDDFSQRLQTTADRPRRWVVVFSPSGCDSMLSALDLLDESSGKAKPKEPNRSTYI 250
Query: 204 PHFAIGNSTA-HKIENLGVEIAGVAAKPKAESLVESVLKYFALQ 246
IG +T H I + G E A +P E + ++ Y L+
Sbjct: 251 A--TIGPTTRDHLIHSFGYEPEVSAEQPSPEGVWNAITSYRTLE 292
>UniRef50_Q5K9B7 Cluster: Uroporphyrinogen-III synthase, putative;
n=1; Filobasidiella neoformans|Rep: Uroporphyrinogen-III
synthase, putative - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 299
Score = 60.1 bits (139), Expect = 5e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 124 FLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSP 183
+LF CG+ + +P L+SEG T+ + VY T + + L L LAFFSP
Sbjct: 178 YLFLCGDKSLDEMPTALRSEGRTVKEVVVYTTSARHDFQQGLRRLETPVRHKGWLAFFSP 237
Query: 184 SGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKI-ENLGVEIAGVAAKPKAESLVESVLK 241
S + Q++ + R FAIG +T + E +E+ VA +P A E+++K
Sbjct: 238 SSAAIVMPQIKQDNGRWDGWRVFAIGETTKKYLEEEAKMEVHAVADRPDAIGTFEAIMK 296
>UniRef50_A3LW75 Cluster: Uroporphyrinogen-III synthase; n=2;
Pichia|Rep: Uroporphyrinogen-III synthase - Pichia
stipitis (Yeast)
Length = 259
Score = 59.7 bits (138), Expect = 7e-08
Identities = 61/242 (25%), Positives = 105/242 (43%), Gaps = 16/242 (6%)
Query: 10 SEDYQRIFRENNFETIFVEPLQFIYINIEELSQKLLQNDYDG----MILTSPRAVEAVSK 65
++ Y+ IF EN F F+ L + + E + L +++ I+TS RAVE +
Sbjct: 17 TDPYEGIFLENGFCPEFLPLLTHRHFDRERTLEYLRSSEFVDEIPVFIITSQRAVEMLGD 76
Query: 66 CWDPTKFVIWN---SKDVYTVGEMSSQKIKX-XXXXXXXXXXXXNAENLSKIILKDKKKT 121
C + + SK YTVG + +K N L+++I ++
Sbjct: 77 CLSSLEQEVKKKILSKIGYTVGPATFSVLKTLGFSSIRGGERAGNGSKLAELIHEEVGDI 136
Query: 122 ST-FLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSG--L 178
ST +F G +R + IP L L +Y T+ ++ ++ N + SG +
Sbjct: 137 STRMVFFTGVVRKDIIPRKLMEWNHNLQETVIYTTEVRDD---VVKNFTNYIERTSGGWI 193
Query: 179 AFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVES 238
FFSP G E I ++ + R S +IG +T + ++ A+KP A SL E+
Sbjct: 194 VFFSPQGTESIVEYIR--NQRQSQFKLASIGPTTEEYLLENSIKPDITASKPHASSLYEA 251
Query: 239 VL 240
++
Sbjct: 252 IV 253
>UniRef50_A5FLE6 Cluster: Uroporphyrinogen III synthase HEM4; n=2;
Flavobacterium|Rep: Uroporphyrinogen III synthase HEM4 -
Flavobacterium johnsoniae UW101
Length = 221
Score = 59.3 bits (137), Expect = 9e-08
Identities = 61/219 (27%), Positives = 100/219 (45%), Gaps = 22/219 (10%)
Query: 25 IFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYTVG 84
I +E ++ +I E +L + + +I TS AV +V +P + SK+VY VG
Sbjct: 24 IGIEVIEADFIKTENKPFELKDLN-ESLIFTSQNAVHSVLS--NPKSEEL-KSKNVYCVG 79
Query: 85 EMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEG 144
+ K A +L++II S + F GNLR +T+P L+ G
Sbjct: 80 LKT--KTLLSDNGFNVVAYTGYASDLAEIITLIYGNES-YTFFSGNLRRDTLPEALKEAG 136
Query: 145 ITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLP 204
I L+ I VYET ++ + +P L FFSPSG + + T + +L
Sbjct: 137 IKLNEIQVYET---------TLQPQKIKANPEALLFFSPSGVKSYLKD-NTINKQLC--- 183
Query: 205 HFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLKYF 243
F IG +TA + + I +A +P E ++E V++ +
Sbjct: 184 -FCIGETTAEALHKITKNII-IADQPTIEDVIEDVIQEY 220
>UniRef50_Q6BQF3 Cluster: Similar to CA0849|CaHEM4 Candida albicans
CaHEM4 uroporphyrinogen III synthase; n=1; Debaryomyces
hansenii|Rep: Similar to CA0849|CaHEM4 Candida albicans
CaHEM4 uroporphyrinogen III synthase - Debaryomyces
hansenii (Yeast) (Torulaspora hansenii)
Length = 264
Score = 59.3 bits (137), Expect = 9e-08
Identities = 60/214 (28%), Positives = 94/214 (43%), Gaps = 17/214 (7%)
Query: 37 IEELSQKLLQNDYDGMILTSPRAVEAVSKCW-----DPTKFVIWNSKDVYTVGEMSSQKI 91
+E L K N I+TS RAVE ++C + K I+ K YTVG +++ +
Sbjct: 45 VEYLKSKEFSN-IRNFIITSQRAVECFNECIQEINDENIKQSIFQ-KIGYTVGPATAKIL 102
Query: 92 -KXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAI 150
+ N LSKII+ + +F G +R + IP L+ I +
Sbjct: 103 SEAGFKTVKGGNDAGNGLILSKIIIDEIAPEEEIVFFTGKIRKDIIPKNLKLANINIMER 162
Query: 151 TVYETQENENLK-------ALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLL 203
+Y T E++ +LL + NN+ + FFSP G E I +L+ N S
Sbjct: 163 VIYRTDLREDIGETFNKQLSLLDQTNNIEKK--WIIFFSPQGTELIIEKLKQLDNLTSQF 220
Query: 204 PHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVE 237
+IG +T + + G+ V+ KP+A SL E
Sbjct: 221 YIGSIGPTTEDYLVSRGITPNIVSKKPEAASLFE 254
>UniRef50_A6ELI7 Cluster: DNA methylase, putative; n=1; unidentified
eubacterium SCB49|Rep: DNA methylase, putative -
unidentified eubacterium SCB49
Length = 380
Score = 57.2 bits (132), Expect = 4e-07
Identities = 44/134 (32%), Positives = 62/134 (46%), Gaps = 14/134 (10%)
Query: 109 NLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMEL 168
+L++II+K KK S LF CG R + IPN L + I + + Y+T ++
Sbjct: 254 DLAQIIVKKYKKESFHLF-CGEQRRDEIPNTLNASKINISEVKTYKT---------TLKP 303
Query: 169 NNLNDSPSGLAFFSPSGCE-YIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVA 227
N G+ FFSPSG E Y N SLL F IGN+TA+ I +A
Sbjct: 304 RKFNQKWDGILFFSPSGVESYFKENQDQQLNNKSLL--FCIGNTTANAARKYSDHIV-IA 360
Query: 228 AKPKAESLVESVLK 241
ES++ +K
Sbjct: 361 NSTLVESVIAKAVK 374
>UniRef50_P87214 Cluster: Uroporphyrinogen-III synthase; n=1;
Schizosaccharomyces pombe|Rep: Uroporphyrinogen-III
synthase - Schizosaccharomyces pombe (Fission yeast)
Length = 251
Score = 57.2 bits (132), Expect = 4e-07
Identities = 58/241 (24%), Positives = 104/241 (43%), Gaps = 19/241 (7%)
Query: 11 EDYQRIFRENNFETIFVEPLQFIYINIEELSQKL--LQNDYDGMILTSPRAVEAVSKCW- 67
+ Y F + +T F+ L+ ++ E+L KL ++ Y G+I+TS R E + +
Sbjct: 15 DPYVEAFEKYGRDTAFIPVLRHKRVHEEQLRDKLKNVRKTYCGLIVTSQRVSETLDEALK 74
Query: 68 --DPT-KFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILK---DKKKT 121
D T + I ++TVG + I+ E L+ +I + K+
Sbjct: 75 QEDETERQKILMETPIFTVGPATDDSIRRLGFQQTHGKDCGRGEVLADLIEEWYTTTKQH 134
Query: 122 STFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFF 181
LF G + I L + + D++ VY TQE EN + + + + + + F
Sbjct: 135 KPLLFLVGEKHRDIIQRKLGDDRV--DSLIVYATQELENTETQIKDTIRKHPTIDWIVAF 192
Query: 182 SPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLK 241
SP+ I L TF +++ IG +T ++ LG + V+ P ESL S++
Sbjct: 193 SPTS---ICSLLNTFELKIA-----TIGPTTGDYLKKLGTQPNVVSPAPNPESLASSIVA 244
Query: 242 Y 242
+
Sbjct: 245 F 245
>UniRef50_UPI00015BCF14 Cluster: UPI00015BCF14 related cluster; n=1;
unknown|Rep: UPI00015BCF14 UniRef100 entry - unknown
Length = 240
Score = 56.4 bits (130), Expect = 6e-07
Identities = 65/242 (26%), Positives = 109/242 (45%), Gaps = 25/242 (10%)
Query: 2 KIVLFKGESEDYQ--RIFRENNFETIFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRA 59
K++L + E ++ + +IF N TI + ++ I E L D+D +I +S +A
Sbjct: 15 KLLLTREEEKNLESKKIFSSYNINTISLPMIETIPKEFE-----LKDFDFDCIIFSSRKA 69
Query: 60 VEAVSKCWDPTKFVIWNSK-DVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDK 118
VE K + N+K +VY VGE + + E L + K
Sbjct: 70 VEIFFK----NLHICKNAKINVYIVGEKTKEYFLGFYNTKNLIARDSIKEILPIVNCKTL 125
Query: 119 KKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQEN-ENLKALLMELNNLNDSPSG 177
+ F P E I NM++++ I + + Y+T+ L+ +L L +N G
Sbjct: 126 WIRTDFELP------EDIKNMVKNKDIFI--LEAYKTKHKIYELRKVLETLKAVN----G 173
Query: 178 LAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVE 237
+ F SPS + + LQ + L+ FAIGN+TA I+N G ++ V KP ES+ +
Sbjct: 174 VFFASPSAFLGLLKNLQNYKYILNEKDIFAIGNTTADAIKNEGFQVTYVPQKPSVESIAK 233
Query: 238 SV 239
+
Sbjct: 234 YI 235
>UniRef50_A4BYX0 Cluster: Porphobilinogen deaminase HemC; n=11;
Bacteroidetes|Rep: Porphobilinogen deaminase HemC -
Polaribacter irgensii 23-P
Length = 531
Score = 54.0 bits (124), Expect = 3e-06
Identities = 54/229 (23%), Positives = 102/229 (44%), Gaps = 26/229 (11%)
Query: 18 RENNFETIFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVIWNS 77
+E I +E FI + + K+++ ++ +I+TS VEA+ + +
Sbjct: 326 KETLSSAIGIEDSDFIKMRFNRIPAKVMKQVHENVIITSQNGVEAILNSFAKEEITF--- 382
Query: 78 KDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIP 137
K+++ VG + + I+ A L++ I K F C ++R + +P
Sbjct: 383 KNIFCVGRRTKKLIENRIGKVTHAAKSALA--LAEYISKQTAIKQVSYF-CSDVRLDVLP 439
Query: 138 NMLQSEGITLDAITVYETQENE-NLKALLMELNNLNDSPSGLAFFSPSGCE-YIHRQLQT 195
LQ+ +T+ + Y+T N +KA + SG+ FFSPSG E Y+ +
Sbjct: 440 TYLQAHEVTVHEVEAYKTMLNPIKIKAAV----------SGVLFFSPSGIESYLE---EN 486
Query: 196 FSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLKYFA 244
+++++ F IG +TA + + VA P E ++E V Y++
Sbjct: 487 ATDKVA----FCIGETTA-VVARKYFDKVEVANMPDVECVLELVNTYYS 530
>UniRef50_A0M6C3 Cluster: Uroporphyrinogen-III synthase; n=1;
Gramella forsetii KT0803|Rep: Uroporphyrinogen-III
synthase - Gramella forsetii (strain KT0803)
Length = 216
Score = 53.6 bits (123), Expect = 4e-06
Identities = 52/211 (24%), Positives = 95/211 (45%), Gaps = 26/211 (12%)
Query: 30 LQFIYINIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQ 89
+++ I+I+ + L + ++ I TS AV A+ K + K+ + VGE ++
Sbjct: 26 VEYDAISIKSIDFDLKKEVFENTIFTSKNAVRAIQG-----KDI--KIKNCFCVGEKTAT 78
Query: 90 KIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDA 149
+ N +L++ I++ K + F F CGN R E +P +L+ I L
Sbjct: 79 FLNEKGFSVLETAD--NGTDLAQKIIQ-KHREKQFHFFCGNKRREELPQLLKKSNIQLSE 135
Query: 150 ITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIG 209
VY+T N G+ FFSPS Q T N+++ + F IG
Sbjct: 136 TVVYKTALNP---------KKFESHFDGILFFSPSAV-----QSFTKKNKINSIA-FCIG 180
Query: 210 NSTAHKIENLGVEIAGVAAKPKAESLVESVL 240
+TA++++ + +A+KP E+++ V+
Sbjct: 181 ETTANEVKKHSENVV-IASKPSIENVIVKVV 210
>UniRef50_Q9K8G1 Cluster: Uroporphyrinogen III cosynthase; n=1;
Bacillus halodurans|Rep: Uroporphyrinogen III cosynthase
- Bacillus halodurans
Length = 253
Score = 53.2 bits (122), Expect = 6e-06
Identities = 57/242 (23%), Positives = 99/242 (40%), Gaps = 6/242 (2%)
Query: 7 KGESEDYQRIFRENNFETIFVEPLQFIY-INIEELSQKLLQNDYDGMILTSPRAVEAVSK 65
K ++ R+ E I V L FI +++ E +Q+ Y+ ++ TS AV
Sbjct: 17 KEQASSLSRLIEEAGGVPIEVPLLSFIKTMDVYEEVGASIQS-YEWIVFTSANAVRFFFN 75
Query: 66 CWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFL 125
W + + + VG + +++ AE+L + ++K + K L
Sbjct: 76 TWPRQE--LKKLPSIAAVGSSTQRELSRYGISVDLMPNEYVAESLVETMVK-RLKPCRVL 132
Query: 126 FPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSG 185
FP GNL T+ L++ G +D +TVYET+ K +L E + + F SPS
Sbjct: 133 FPKGNLARPTVKVGLETNGFIVDEMTVYETKRPLEAKVMLCEAFQKHRIEI-ITFTSPSA 191
Query: 186 CEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLKYFAL 245
++ L L + IG A + + G+ + VA E LV ++ +
Sbjct: 192 VDHFVTLLDREFILHEHLLYAYIGPIAAARAKQRGLPVHIVAKTYTGEGLVNAICDFVKE 251
Query: 246 QG 247
G
Sbjct: 252 DG 253
>UniRef50_Q5KWK7 Cluster: Uroporphyrinogen III cosynthase; n=2;
Geobacillus|Rep: Uroporphyrinogen III cosynthase -
Geobacillus kaustophilus
Length = 256
Score = 49.2 bits (112), Expect = 1e-04
Identities = 37/142 (26%), Positives = 66/142 (46%), Gaps = 2/142 (1%)
Query: 107 AENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLM 166
AE L+ ++ K+ LF G+L S T+P L+ G +D TVY+T + + + L+
Sbjct: 115 AERLAAMLAPRVKQGDRVLFVKGDLASPTLPEALRKAGAAVDEFTVYQTVPDLSGREPLL 174
Query: 167 ELNNLNDSPSGLAFFSPSGCEYIHRQL-QTFSNRLSLLPHFAIGNSTAHKIENLGVEIAG 225
L + SPS + R L + S LS + IG T E G+ +
Sbjct: 175 ALLR-ERKLDAITLMSPSAVHSLARLLGEEASALLSGVAVACIGPVTKKAAEREGITVHI 233
Query: 226 VAAKPKAESLVESVLKYFALQG 247
A + +++++ +YF+++G
Sbjct: 234 CPADYTTDGIIKAMEQYFSMEG 255
>UniRef50_Q8Y6X6 Cluster: Lmo1555 protein; n=13; Listeria|Rep:
Lmo1555 protein - Listeria monocytogenes
Length = 240
Score = 48.8 bits (111), Expect = 1e-04
Identities = 55/224 (24%), Positives = 101/224 (45%), Gaps = 11/224 (4%)
Query: 2 KIVLFKGESED--YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRA 59
K+VL + S++ +Q F +N +E + + ++ I I L+++ Q + D + LTS A
Sbjct: 4 KVVLTREASKNKPWQTYFSQNGYEVMSIPLIKTQPIKIN-LTRE--QQETDWLFLTSANA 60
Query: 60 VEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKK 119
VE + ++ N K + +GE + +K+ +E + L +
Sbjct: 61 VEY----FFTNQYERSNYK-IAVIGEKTKEKLAEFGHEPSFVPSIYQSEVFLEEWLNENP 115
Query: 120 KTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLA 179
+ ++ L P NL I + L +G + +I +YET E K LL E LN++ +
Sbjct: 116 EKTSILLPQSNLSRTIIKDTLIEKGYIVFSIELYETIFPEASKKLLTEQLKLNETQI-IV 174
Query: 180 FFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEI 223
F SPS + + ++F + +IG+ T I G E+
Sbjct: 175 FASPSAWKNFYSIAKSFPAQKEKWHIASIGSITTEAILADGWEV 218
>UniRef50_A2TR69 Cluster: Uroporphyrinogen-III synthetase; n=1;
Dokdonia donghaensis MED134|Rep: Uroporphyrinogen-III
synthetase - Dokdonia donghaensis MED134
Length = 226
Score = 46.0 bits (104), Expect = 9e-04
Identities = 50/200 (25%), Positives = 87/200 (43%), Gaps = 22/200 (11%)
Query: 18 RENNFETIFVEPLQFIY---INIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVI 74
+ N E + LQF+ I +E+S L + +I+TS V A+ C + + +
Sbjct: 10 KPNQRELLLNAGLQFVEYDAIRTQEVSFTLSRK-LKNIIITSQNGVRAL--CNNLSSEQL 66
Query: 75 WNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSE 134
+ K + VG ++ + N E L+ I K+ K S F + CG R +
Sbjct: 67 ESIKSCFAVGIKTTALL--AENGIKVTKTAQNGEELAHFIAKNHKSES-FTYFCGRQRRD 123
Query: 135 TIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQ 194
+P +L+ + + + VYET + + + D G+ FFSPSG ++ +
Sbjct: 124 ELPTLLKENNVACEEVVVYETHQ------ITQSFDRTFD---GILFFSPSG---VNAFAK 171
Query: 195 TFSNRLSL-LPHFAIGNSTA 213
N L++ F IG +TA
Sbjct: 172 ANKNTLAIDSIAFCIGETTA 191
>UniRef50_Q59Y07 Cluster: Potential uroporphyrinogen-III synthase
Hem4p; n=3; Saccharomycetales|Rep: Potential
uroporphyrinogen-III synthase Hem4p - Candida albicans
(Yeast)
Length = 271
Score = 45.2 bits (102), Expect = 0.002
Identities = 50/210 (23%), Positives = 89/210 (42%), Gaps = 14/210 (6%)
Query: 47 NDYDGMILTSPRAVEAVSKCWDPTKFVIWN---SKDVYTVGEMSSQKIKXXXXXXXXXXX 103
N+ I+TS RAVE +C + I K YTVG + + +K
Sbjct: 56 NNIPIFIITSQRAVEMFKECIEELNHDIRQRIYQKIGYTVGPATYKILKSVGFKDVRGGD 115
Query: 104 XX-NAENLSKIILKDK--KKTSTFLFPCGNLRSETIPNMLQSEGIT-LDAITVYETQEN- 158
N L+ +I +D ++ +F G +R + IP L G +Y+T +
Sbjct: 116 EAGNGSKLADLIKQDTIGRENIPMVFFTGVIRKDIIPRKLIDSGYNNFQEFILYQTGDRL 175
Query: 159 ---ENLKALLMELNNLNDSPS-GLAFFSPSGCEYIHRQL--QTFSNRLSLLPHFAIGNST 212
+N K ++ L+ D+ + FFSP G + I L + ++ +IG +T
Sbjct: 176 DIIDNFKKVIHGLDKDKDNDDVWIVFFSPQGTKEIVNYLIDRDGNSNQKNWKIASIGPTT 235
Query: 213 AHKIENLGVEIAGVAAKPKAESLVESVLKY 242
+++ + +A KP E+L E++ +Y
Sbjct: 236 RDYLKDFDLSPHVIAPKPDPEALFETIFQY 265
>UniRef50_Q54NS4 Cluster: Putative uroporphyrinogen III synthase;
n=1; Dictyostelium discoideum AX4|Rep: Putative
uroporphyrinogen III synthase - Dictyostelium discoideum
AX4
Length = 383
Score = 44.8 bits (101), Expect = 0.002
Identities = 43/154 (27%), Positives = 66/154 (42%), Gaps = 23/154 (14%)
Query: 78 KDVYTVGEMSS---QKIKXXXXXXXXXXXXXNAENLSKIILKD----------KKKTSTF 124
K +Y +GE S +K+ NA +L+K I D
Sbjct: 159 KHIYLIGETSCNLFKKVFGKWISQNVIVVESNATDLAKRITLDYNNEYKENNNNDNNKAL 218
Query: 125 LFPCGNLRSETIPNMLQSEGITLDAITVYETQE-----NENLKALLMELNNLNDSPSGLA 179
L+ CGN R E +P L++ I L + Y++Q N+ L + L + L
Sbjct: 219 LYFCGNQRREELPLYLKNNNIQLKELVTYQSQTSDDSINDILNLIKRVLQSNKMEIYWLV 278
Query: 180 FFSPSGCEYIHRQLQTFSNRLSL--LPHFAIGNS 211
FFSPSG +++ L+T N+LS LP +I N+
Sbjct: 279 FFSPSGVDFV---LETIDNQLSALSLPRTSIFNN 309
>UniRef50_Q756B6 Cluster: AER351Wp; n=1; Eremothecium gossypii|Rep:
AER351Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 262
Score = 43.6 bits (98), Expect = 0.005
Identities = 59/260 (22%), Positives = 110/260 (42%), Gaps = 26/260 (10%)
Query: 2 KIVLFKGES--ED-YQRIFRENNFETIFVEPLQFIYINIE---ELSQKLLQNDYDGMILT 55
KI+ K ++ ED Y+ IF N F+T FV + ++ E LS + +++T
Sbjct: 6 KIIFLKNKTVPEDHYETIFESNGFQTHFVPIITHEHLPDEVRGRLSDANYMKRLNCLVVT 65
Query: 56 SPRAVEAVSKCWDPT-----KFVIWNSKDVYTVGEMSSQKIKX-XXXXXXXXXXXXNAEN 109
S R VE + + P+ + + N+ V+ VG + + ++ N
Sbjct: 66 SQRTVECLYEDVLPSLPAEARKSLLNTP-VFVVGRATQEFMERCGFTDVRGGSETGNGVL 124
Query: 110 LSKIILK-----DKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKAL 164
L++++L D + TFL G +R + I L+S + ++ I Y T ++
Sbjct: 125 LAELMLNMIQKGDISSSGTFLLLVGEIRRDIIKKRLESAELEVEEIITYRTSPLHDISER 184
Query: 165 LMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIA 224
+ N S + FSP G + L+ + +++ AIG +TA + +
Sbjct: 185 FERVFTDN---SWVVLFSPQGTNELLPLLRQGAAKIA-----AIGPTTAQYLLDNATPPI 236
Query: 225 GVAAKPKAESLVESVLKYFA 244
+ KP+ SL ++ Y A
Sbjct: 237 LTSPKPEPSSLCNAIKDYLA 256
>UniRef50_Q58401 Cluster: Putative uroporphyrinogen-III synthase;
n=6; Methanococcales|Rep: Putative uroporphyrinogen-III
synthase - Methanococcus jannaschii
Length = 240
Score = 43.6 bits (98), Expect = 0.005
Identities = 42/174 (24%), Positives = 75/174 (43%), Gaps = 12/174 (6%)
Query: 1 MKIVLF--KGESEDYQRIFRENNFETIFVEPLQFIYINIEELSQKLLQNDYDGMILTSPR 58
MK+V+ K ++ + + ++ FE I L+ +Y ++L L + YD + TSP
Sbjct: 1 MKVVITRPKERADVFASLLKKEGFEPIIFPTLEIVYN--KDLDVNL--DSYDWIAFTSPS 56
Query: 59 AVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXX-XXXNAENLSKIILKD 117
V + + +K + +GE +++ K AE+L + I K
Sbjct: 57 GVIGLYNILTENERENVKNKKIAVIGEKTAKTFKKYFGRDPDIMPNEYTAESLLREIKKV 116
Query: 118 KKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNL 171
K+ FL P + + N L + D + VY++ E ENLK + +L L
Sbjct: 117 SKEEEKFLIPTTPSTRDVLKNNLNA-----DLLFVYKSAEPENLKEDIKKLKEL 165
>UniRef50_A6S7S1 Cluster: Putative uncharacterized protein; n=4;
Pezizomycotina|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 317
Score = 43.2 bits (97), Expect = 0.006
Identities = 56/212 (26%), Positives = 92/212 (43%), Gaps = 39/212 (18%)
Query: 19 ENNFETIFVEPLQFIYIN--IEELSQKLLQN--------DYDGMILTSPRAVEAVSKCW- 67
E FE FV L+ +++ ++E+ + L + +Y G+I TS RAVE +K
Sbjct: 41 ERGFEPTFVPVLEHRFVDEGVDEVKRLLKERGIGREEGKEYGGLIFTSQRAVELFAKLVE 100
Query: 68 ------DPTKFVIWNSKDVYTVGEMSSQKIKX---XXXXXXXXXXXXNAENLSKIIL--- 115
D ++ + +YTVG +S+ ++ N E L+ +L
Sbjct: 101 EGRSEDDSDEWPYLQNIPIYTVGPATSRALRSIPQTPALNIFGAESGNGEALAHYMLEHY 160
Query: 116 ----KDKKKTSTFLFPCGNLRSETIPNMLQ----SEG--ITLDAITVYET----QENENL 161
K++ + LF G R + IP L S+G I +D + VY T E+
Sbjct: 161 GNWYKNRCVKPSLLFMVGEQRRDIIPRTLMDPELSDGKRIQVDELVVYGTGVMESFEEDF 220
Query: 162 KALLMELNNLNDSPSGLAFFSPSGCEYIHRQL 193
KALL E + + + FSP+GC+ + R L
Sbjct: 221 KALLKETEHRD--TRWVVVFSPTGCDAMLRSL 250
>UniRef50_A4CHM2 Cluster: Uroporphyrinogen-III synthase; n=1;
Robiginitalea biformata HTCC2501|Rep:
Uroporphyrinogen-III synthase - Robiginitalea biformata
HTCC2501
Length = 223
Score = 42.7 bits (96), Expect = 0.008
Identities = 36/132 (27%), Positives = 65/132 (49%), Gaps = 16/132 (12%)
Query: 107 AENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLM 166
AE L++ I+ +K + +F++ C + R +T+P+ L G+ L+ VY+T N+ +
Sbjct: 97 AELLAERII-NKYSSRSFIYFCSSRRLDTLPDRLLEAGVRLEERVVYQTGFNQRI----- 150
Query: 167 ELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGV 226
L+ + FFSPSG E SN+L IG +TA ++ +
Sbjct: 151 ----LDKQFDAILFFSPSGVESF-----LGSNQLHDATAICIGPTTAQAVKKHTDKFIS- 200
Query: 227 AAKPKAESLVES 238
A P AE+++++
Sbjct: 201 AESPSAEAVLQA 212
>UniRef50_A3XGZ5 Cluster: DNA methylase, putative; n=1;
Leeuwenhoekiella blandensis MED217|Rep: DNA methylase,
putative - Leeuwenhoekiella blandensis MED217
Length = 350
Score = 42.7 bits (96), Expect = 0.008
Identities = 52/212 (24%), Positives = 86/212 (40%), Gaps = 22/212 (10%)
Query: 30 LQFIYINIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQ 89
+++ I IE L + +N + +I TS V+A K S + VG +
Sbjct: 158 VEYDAIQIEFLDVEFPKN-LENLIFTSKNGVQAFLKMQPDLNT---ESFSCFCVGSKTES 213
Query: 90 KIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDA 149
+ NA +L+ I+K+ + F F C +R +P L + +
Sbjct: 214 SLMKKGLNVVKTAQ--NAADLADFIVKNYQNEH-FSFFCSTIRRNELPEHLTKNQVPFEE 270
Query: 150 ITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIG 209
I Y+TQ N K E + + FFSPSG + + F N LS+ IG
Sbjct: 271 IVCYKTQ--LNTKEFKQEFD-------AVLFFSPSGVQSF-SAVNNFKNMLSV----CIG 316
Query: 210 NSTAHKIENLGVEIAGVAAKPKAESLVESVLK 241
N+TA +++ + VA ES++ +K
Sbjct: 317 NTTAAEVQQHTQNVT-VANATTIESVIARAVK 347
>UniRef50_Q81LC8 Cluster: Uroporphyrinogen-III synthase; n=10;
Bacillus cereus group|Rep: Uroporphyrinogen-III synthase
- Bacillus anthracis
Length = 250
Score = 42.3 bits (95), Expect = 0.011
Identities = 41/162 (25%), Positives = 65/162 (40%), Gaps = 10/162 (6%)
Query: 29 PLQFIYINIEELSQKLLQN------DYDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYT 82
PL+ + +E + + +Q+ YD +I TS V C V + +
Sbjct: 32 PLEIPLLRMEGMFHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDCLGKKLPV---TTKIAA 88
Query: 83 VGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQS 142
VG + +++ AE ++ +K LFP GNL E IP L+
Sbjct: 89 VGVKTKLELEKRGYHVDFVPTSFVAEAFAEEFVKRLSGNERILFPKGNLAREVIPVALRE 148
Query: 143 EGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPS 184
G++LD + VY T+ N K L+ L + F SPS
Sbjct: 149 IGVSLDELIVYGTKVNIEKKQELIAALKLG-KVDIITFTSPS 189
>UniRef50_Q1INI7 Cluster: Uroporphyrinogen III synthase HEM4; n=1;
Acidobacteria bacterium Ellin345|Rep: Uroporphyrinogen
III synthase HEM4 - Acidobacteria bacterium (strain
Ellin345)
Length = 272
Score = 42.3 bits (95), Expect = 0.011
Identities = 34/140 (24%), Positives = 60/140 (42%), Gaps = 4/140 (2%)
Query: 48 DYDGMILTSPRAVEAVSKCWDPTKFV--IWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXX 105
DYD +ILTS V A+ + + K ++ + +G + + I+
Sbjct: 67 DYDWLILTSVNGVNALFRRLEKLKLRPDLFEKLKIAAIGPATKKAIEGQRLKVEVTPKEY 126
Query: 106 NAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALL 165
AE + + + + K K L + + IPN L+ G +D + YET E + L
Sbjct: 127 VAEAVVEALAR-KVKGKRVLLVRAKVARDVIPNELRRAGANVDVVEAYETVVPEKSRGKL 185
Query: 166 ME-LNNLNDSPSGLAFFSPS 184
+ L++L + P + F S S
Sbjct: 186 SDALHSLKNKPQVITFTSSS 205
>UniRef50_A0GXZ0 Cluster: Uroporphyrinogen III synthase HEM4; n=2;
Chloroflexus|Rep: Uroporphyrinogen III synthase HEM4 -
Chloroflexus aggregans DSM 9485
Length = 254
Score = 42.3 bits (95), Expect = 0.011
Identities = 31/122 (25%), Positives = 52/122 (42%), Gaps = 5/122 (4%)
Query: 125 LFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPS 184
L PC ++ T+ LQ+ G +D +T Y T + L L + + + S S
Sbjct: 130 LLPCADIAPSTLTAALQAAGAIVDRVTAYRTISSPAAAELAAALR--SGTIDAIVLASGS 187
Query: 185 GCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLKYFA 244
I L + P IG STA LG+ +A +A +P ++L+ ++ + F
Sbjct: 188 AARQIPALLPP---QTQCPPLVCIGPSTAAVCTELGLPVAAIAIRPNDDALLAALERVFL 244
Query: 245 LQ 246
Q
Sbjct: 245 SQ 246
>UniRef50_A2U8Q2 Cluster: Uroporphyrinogen III synthase HEM4; n=1;
Bacillus coagulans 36D1|Rep: Uroporphyrinogen III
synthase HEM4 - Bacillus coagulans 36D1
Length = 262
Score = 41.9 bits (94), Expect = 0.014
Identities = 37/142 (26%), Positives = 59/142 (41%), Gaps = 3/142 (2%)
Query: 107 AENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLM 166
A++ ++ L+ + S L P GNL I + L+ GI + VYET E K L
Sbjct: 120 AKDFAREFLRSGHRASRVLLPKGNLAGTEIADFLRKSGIIAEEWIVYETYMPEGAKEKLT 179
Query: 167 ELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLS-LLPHFA-IGNSTAHKIENLGVEIA 224
L L F SPS + L+ ++ L A IG ST +E G A
Sbjct: 180 RLLGREHIDFAL-FLSPSAFRHFKGALEESGMDIAGLSTRIAVIGPSTRQAVEKAGSRAA 238
Query: 225 GVAAKPKAESLVESVLKYFALQ 246
+ E+++ ++ + L+
Sbjct: 239 VCPDEYTVEAMLGALCDFVRLE 260
>UniRef50_A5UU38 Cluster: Uroporphyrinogen III synthase HEM4; n=2;
Roseiflexus|Rep: Uroporphyrinogen III synthase HEM4 -
Roseiflexus sp. RS-1
Length = 260
Score = 39.9 bits (89), Expect = 0.058
Identities = 47/208 (22%), Positives = 86/208 (41%), Gaps = 18/208 (8%)
Query: 49 YDGMILTSPRAVEAVSK--CWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXN 106
YD ++ TS AV+A+++ P V V VG+ ++ I+ N
Sbjct: 62 YDWIVFTSAAAVDALAEQGALPPPAHV-----RVAAVGKATAASIEARGGRVDLIPAEQN 116
Query: 107 AENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLM 166
AE L + K FL P ++ + + L++ G D + Y T + L+
Sbjct: 117 AEGLLAALHDVAGKR--FLLPVADIARDALAAGLRARGAVADMVIAYRTVPGPGARELIT 174
Query: 167 ELNNLNDSPSGLAFFSPSGCEYIHRQLQTFS-NR------LSLLPHFAIGNSTAHKIENL 219
L + + F SPS Y+ ++ F +R L+ + AIG +TA + +
Sbjct: 175 LL--CGRALDAILFSSPSTLRYLLDGMEQFGIDRSVARALLTGVALIAIGPTTARALRDE 232
Query: 220 GVEIAGVAAKPKAESLVESVLKYFALQG 247
G+ +A A P +++++ A +G
Sbjct: 233 GLPVAAQAPTPDTGGVLQALYDGLAEKG 260
>UniRef50_Q8KCJ3 Cluster: Uroporphyrinogen-III synthase; n=11;
Chlorobiaceae|Rep: Uroporphyrinogen-III synthase -
Chlorobium tepidum
Length = 246
Score = 39.9 bits (89), Expect = 0.058
Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 14/183 (7%)
Query: 49 YDGMILTSPRAVEAVSKCW---DPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXX 105
+ G+ TSP +V+ + P + V+ VG+ + ++
Sbjct: 49 FAGIFFTSPNSVQFFLERLLEESPDELPNLQQARVWAVGKTTGGDLEKHGVSIEPLPKSA 108
Query: 106 NAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYET-----QENEN 160
+A +L I + + TFLF G+L TIP ++ G +TVY+ +E +
Sbjct: 109 DAVSLMSGIDASEIEGKTFLFVRGSLSLGTIPEVIAKRGGICVELTVYDNIQPSLEETQK 168
Query: 161 LKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLG 220
+K+LL E L+F SPS + + +L AIG +T+ +E LG
Sbjct: 169 IKSLLTE-----GKIDCLSFTSPSTAINFFEAIDSKEVPSDVL-IAAIGTTTSSALEKLG 222
Query: 221 VEI 223
V++
Sbjct: 223 VKV 225
>UniRef50_A0L5L4 Cluster: Uroporphyrinogen III synthase HEM4; n=1;
Magnetococcus sp. MC-1|Rep: Uroporphyrinogen III
synthase HEM4 - Magnetococcus sp. (strain MC-1)
Length = 259
Score = 39.5 bits (88), Expect = 0.077
Identities = 35/197 (17%), Positives = 80/197 (40%), Gaps = 1/197 (0%)
Query: 47 NDYDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXN 106
+ +DG+++TS A A + + + VG +++ ++ +
Sbjct: 59 HSFDGVLITSANAARAYLDALAAQAQPLSGTPPCFAVGPKTAELLRAGGATVCQPSSRFD 118
Query: 107 AENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLM 166
E L++ I + + K FLFP + ET+ + L+++ + + Y + L A
Sbjct: 119 GEALAEAINQWQGKGRHFLFPRAAIGRETLIDGLENDDHRVTMVAAYRALPAQQLSAQAH 178
Query: 167 ELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGV 226
+ L F S + + + ++ A+ TA ++ +LG +
Sbjct: 179 RYLREKRVDAALFFSSRTATTFFELLISQALEPAEMV-LAALSPVTAERMASLGFAAHVI 237
Query: 227 AAKPKAESLVESVLKYF 243
A + AESL++++ ++
Sbjct: 238 APQATAESLLQALADHW 254
>UniRef50_A3U6E9 Cluster: Uroporphyrinogen-III synthase; n=1;
Croceibacter atlanticus HTCC2559|Rep:
Uroporphyrinogen-III synthase - Croceibacter atlanticus
HTCC2559
Length = 217
Score = 39.1 bits (87), Expect = 0.10
Identities = 36/120 (30%), Positives = 53/120 (44%), Gaps = 15/120 (12%)
Query: 122 STFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFF 181
+TF F CGN R + +P +L I L I VY+T + N+K N + F
Sbjct: 107 ATFTFFCGNKRRDALPELLHKHNINLTEIEVYKT--SLNIKEFQRTFN-------AIMCF 157
Query: 182 SPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLK 241
SPSG Q +N+ IGN+TA + +IA +A ES++ +K
Sbjct: 158 SPSGV-----QSYFGANKPQKETIVCIGNTTATAAKLYTDQIA-IANTTSIESVIAKTVK 211
>UniRef50_Q3ACT2 Cluster: Uroporphyrinogen-III synthase; n=1;
Carboxydothermus hydrogenoformans Z-2901|Rep:
Uroporphyrinogen-III synthase - Carboxydothermus
hydrogenoformans (strain Z-2901 / DSM 6008)
Length = 343
Score = 38.7 bits (86), Expect = 0.14
Identities = 50/190 (26%), Positives = 75/190 (39%), Gaps = 6/190 (3%)
Query: 25 IFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVIWNS-KDVYTV 83
I V L+ YI E + Q L + YD +I TS VE + + N + V
Sbjct: 124 IEVPLLKITYIPDERILQ-LDFSAYDWLIFTSAHGVEGFFFNLNYFNVSLENFIGKIAVV 182
Query: 84 GEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSE 143
GE +++ +K A++L+ + + GNL + +L
Sbjct: 183 GEKTAKALKKYGLTADFSPQKFTAKDLALELTTSGMIQKGVIVIQGNLGRPELLEILARN 242
Query: 144 GITLDAITVYETQENENLKALLMELNNLNDSPSGLAFF-SPSGCEYIHRQLQTFSNRLSL 202
I + VYE N ++K L L L + FF SPS + Q + N
Sbjct: 243 NIPTKKLVVYENAPNVDIKPFLNGL--LKAKLIDVLFFTSPSTFNNFY-QFISDENLAKN 299
Query: 203 LPHFAIGNST 212
LPHFAIG +T
Sbjct: 300 LPHFAIGPTT 309
>UniRef50_Q1D8Z7 Cluster: Uroporphyrinogen-III synthase; n=2;
Cystobacterineae|Rep: Uroporphyrinogen-III synthase -
Myxococcus xanthus (strain DK 1622)
Length = 256
Score = 38.7 bits (86), Expect = 0.14
Identities = 46/194 (23%), Positives = 74/194 (38%), Gaps = 7/194 (3%)
Query: 49 YDGMILTSPRAVEAVSKCWDP--TKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXN 106
Y ++ SP V+A+ + T+ I K V TVG +++ +
Sbjct: 60 YTWVVFASPTGVDALMEALREAGTQDRIQRVK-VATVGPRTTRAAEGYGLVVVAEPSEGT 118
Query: 107 AENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLM 166
L +I + L P + + L+ G+ + +T Y L
Sbjct: 119 GAALLNLIKDALQPGDEVLLPAAEEGRRELEDGLREYGLLVTRVTAYRATPAPLPPESLA 178
Query: 167 ELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGV 226
L+ P + F SP E + RL+ AIG +TA +E LGV A V
Sbjct: 179 LLDA--SPPDVVLFASPRTAEAFVEEAGR--ERLATARVVAIGPTTASALERLGVPAAAV 234
Query: 227 AAKPKAESLVESVL 240
A +P ESLV++ +
Sbjct: 235 AERPTPESLVDAAV 248
>UniRef50_Q5SI67 Cluster: Probable uroporphyrinogen III synthase;
n=2; Thermus thermophilus|Rep: Probable uroporphyrinogen
III synthase - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 226
Score = 37.9 bits (84), Expect = 0.24
Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 13/118 (11%)
Query: 125 LFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPS 184
LF G+L + L++ G+ + + VY T+E +AL E L + +AFFSPS
Sbjct: 117 LFVAGDLAGRDLEEGLRARGVEVVRLPVYATRE----RALAPEEVALLERAEVVAFFSPS 172
Query: 185 GCEYIHRQLQTFSNRLSLLPH-FAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLK 241
G ++ F+ + P AIG ST + LG + A P E L ++L+
Sbjct: 173 G-------VRAFARWTAKRPKAAAIGPSTGEEARRLGFPVV-EAESPGLEGLFAALLR 222
>UniRef50_Q4AGE3 Cluster: Uroporphyrinogen III synthase HEM4; n=1;
Chlorobium phaeobacteroides BS1|Rep: Uroporphyrinogen
III synthase HEM4 - Chlorobium phaeobacteroides BS1
Length = 256
Score = 37.9 bits (84), Expect = 0.24
Identities = 39/194 (20%), Positives = 74/194 (38%), Gaps = 10/194 (5%)
Query: 49 YDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAE 108
+ +ILTS AV+ + +F I +S + + E ++ ++
Sbjct: 58 HTAIILTSRHAVDHFFRMAKELRFDIPDSLKYFCISESTAYYLQKYVQYRKRKIFYGKQT 117
Query: 109 NLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMEL 168
+ + K FL P +L +++ +ML EGI +Y T + +L
Sbjct: 118 FPDLLEVISKHSEEKFLLPSSDLHKKSMFDMLDKEGIDYTNAVIYRT--------VAADL 169
Query: 169 NNLNDSPSGLA-FFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEI-AGV 226
++++ L FFSP+G + ++ L+ F +TA K ++I A
Sbjct: 170 SHIDPKKFELVIFFSPAGITSLKSNFPDYNQEDQLIAAFGATTATAVKAAGFHLDIPAPT 229
Query: 227 AAKPKAESLVESVL 240
P +E L
Sbjct: 230 QTAPSMTMAIEEYL 243
>UniRef50_A0JYM5 Cluster: Uroporphyrinogen III synthase HEM4; n=1;
Arthrobacter sp. FB24|Rep: Uroporphyrinogen III synthase
HEM4 - Arthrobacter sp. (strain FB24)
Length = 309
Score = 37.9 bits (84), Expect = 0.24
Identities = 24/63 (38%), Positives = 32/63 (50%), Gaps = 4/63 (6%)
Query: 182 SPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLK 241
SPS IH L L AIG STA + E+LG+ +A VA +P LV +V++
Sbjct: 233 SPSAARRIHAGLSP----LGECRFVAIGRSTAAEAESLGLPVAAVAEEPTTSGLVSAVIE 288
Query: 242 YFA 244
A
Sbjct: 289 ALA 291
>UniRef50_Q26GL2 Cluster: Putative uncharacterized protein; n=1;
Flavobacteria bacterium BBFL7|Rep: Putative
uncharacterized protein - Flavobacteria bacterium BBFL7
Length = 220
Score = 37.5 bits (83), Expect = 0.31
Identities = 36/156 (23%), Positives = 68/156 (43%), Gaps = 11/156 (7%)
Query: 35 INIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXX 94
+ I++L + + Y+ +I+TS + A+ W+ SK ++ VG+ + +
Sbjct: 34 LKIQKLKFEYPSSFYNAIIITS---INAIDPLWNRVD----GSKKIFVVGDKTEAAL--L 84
Query: 95 XXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYE 154
NA L+KII+ + F++ CG R + +P L S I + VY+
Sbjct: 85 EKGWHVEVKANNASELAKIIIANYDHLK-FVYFCGLHRRDELPKALLSTQINCVEVKVYD 143
Query: 155 TQENENLKALLMELNNLNDSPSGLAFFSPSGCEYIH 190
+ E + + + SP G+ F+ + E IH
Sbjct: 144 SVAIEKSFDCIFDA-VMFFSPRGVHAFAKANPENIH 178
>UniRef50_A6DQN2 Cluster: Uroporphyrinogen-III synthetase; n=1;
Lentisphaera araneosa HTCC2155|Rep: Uroporphyrinogen-III
synthetase - Lentisphaera araneosa HTCC2155
Length = 229
Score = 37.1 bits (82), Expect = 0.41
Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 106 NAENLSKIILKDKKK--TSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENE 159
+A +L+KII+++KK+ LFPC L + N+L GI++ Y + N+
Sbjct: 102 SASSLAKIIVENKKQFVDKKILFPCSKLAKNDLVNLLAENGISIQRHDFYLPERNQ 157
>UniRef50_A3ETN4 Cluster: Uroporphyrinogen-III methylase; n=1;
Leptospirillum sp. Group II UBA|Rep:
Uroporphyrinogen-III methylase - Leptospirillum sp.
Group II UBA
Length = 516
Score = 37.1 bits (82), Expect = 0.41
Identities = 31/119 (26%), Positives = 56/119 (47%), Gaps = 4/119 (3%)
Query: 129 GNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMEL--NNLNDSPSGLA-FFSPSG 185
G+ IP+ L + G + IT YE + E L L +L + LA F+SPS
Sbjct: 399 GDRGDGAIPDGLAAMGFKIQQITAYENRIPE-LPNYLRDLVSGGFENQDFHLAVFYSPSA 457
Query: 186 CEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLKYFA 244
+ + L+ + AIG +TA + GV + ++P E+++ ++L++F+
Sbjct: 458 YKNLVSLLKEHGQSIRKTTGLAIGPTTADALRKDGVTNILLPSEPTDEAVLTTILQHFS 516
>UniRef50_Q8EPM9 Cluster: Uroporphyrinogen-III synthase; n=1;
Oceanobacillus iheyensis|Rep: Uroporphyrinogen-III
synthase - Oceanobacillus iheyensis
Length = 252
Score = 36.7 bits (81), Expect = 0.55
Identities = 28/135 (20%), Positives = 55/135 (40%), Gaps = 6/135 (4%)
Query: 106 NAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALL 165
+AE ++K ++ + L GNL IPN I+ D I VYET K
Sbjct: 115 DAETMAKEFIESYDREQPILIVRGNLSRNIIPNDFTEHNISYDTIEVYETTYRYEAK--- 171
Query: 166 MELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAG 225
L D+ + F + + + ++ + + IG +T K E L +
Sbjct: 172 ---RELEDTIKNVDFVTLTSPSTVTALMKLVKDIPFSCDYICIGTTTEAKAEKLQIPNLH 228
Query: 226 VAAKPKAESLVESVL 240
+ ++ ++++E ++
Sbjct: 229 IPSEFTTDAMIEVMI 243
>UniRef50_Q4HTB5 Cluster: Uroporphyrinogen-III synthase; n=10;
Campylobacter|Rep: Uroporphyrinogen-III synthase -
Campylobacter upsaliensis RM3195
Length = 214
Score = 36.7 bits (81), Expect = 0.55
Identities = 28/107 (26%), Positives = 47/107 (43%), Gaps = 5/107 (4%)
Query: 48 DYDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNA 107
D++ +ILTS AV+A+ K F + +Y VGE ++++ K
Sbjct: 33 DFNALILTSKNAVKALEKAKIKLNFTL----QIYAVGEKTAKEAKKLGFTKIKIPSLAYG 88
Query: 108 ENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYE 154
+ L KD+ K L+ G + + LQ+ G+ L + VYE
Sbjct: 89 KTLFDEF-KDELKGQKCLYLRGKNIASKLNEDLQNYGVKLKEVIVYE 134
>UniRef50_Q30XG4 Cluster: Uroporphyrin-III C-methyltransferase; n=5;
Bacteria|Rep: Uroporphyrin-III C-methyltransferase -
Desulfovibrio desulfuricans (strain G20)
Length = 503
Score = 36.3 bits (80), Expect = 0.72
Identities = 33/152 (21%), Positives = 64/152 (42%), Gaps = 11/152 (7%)
Query: 22 FETIFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVIWNSK--- 78
F TI + PL+ Y + + ++L + YD ++ TS V V W + +S+
Sbjct: 280 FPTILIRPLED-YAPVHDAIRRLAE--YDWLVFTS---VNGVKHFWQQMGLLGLDSRALG 333
Query: 79 --DVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETI 136
V +G ++ ++ AE + K +++ S L P + E +
Sbjct: 334 GVKVAAIGPATADVLREKGIEPDFIPEKYVAEGVVKGMIERGMDGSRVLLPRARVAREVL 393
Query: 137 PNMLQSEGITLDAITVYETQENENLKALLMEL 168
P L G +D + VYET + ++ ++E+
Sbjct: 394 PEELARAGARVDVLPVYETVPGDANRSHVLEM 425
>UniRef50_A0NYU7 Cluster: Putative uroporphyrinogen III synthase;
n=1; Stappia aggregata IAM 12614|Rep: Putative
uroporphyrinogen III synthase - Stappia aggregata IAM
12614
Length = 238
Score = 35.9 bits (79), Expect = 0.95
Identities = 36/165 (21%), Positives = 72/165 (43%), Gaps = 8/165 (4%)
Query: 80 VYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTST--FLFPCGNLRSETIP 137
V+TVG+ ++ + N + L+++IL + S+ L+P RS +
Sbjct: 75 VFTVGDATALACREAGFTKVHSANG-NIDALAQLILDHRSGLSSGEVLYPAAEDRSGDLE 133
Query: 138 NMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQT-- 195
+L + G++ + VY + L + +++ N N + G+ +S E +++
Sbjct: 134 GLLAAGGVSCRTVVVYRMEAVARLSSTVVDSLNGN-AFDGVLIYSRRTAEAFLALVRSHG 192
Query: 196 FSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVL 240
+ LS LP +A+ +A + VAA P SL++ L
Sbjct: 193 LDHILSGLPVYALSRQSAEPLSE--ASQVRVAAAPNETSLLDLAL 235
>UniRef50_A0CMJ6 Cluster: Chromosome undetermined scaffold_21, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_21,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 618
Score = 35.5 bits (78), Expect = 1.3
Identities = 25/107 (23%), Positives = 50/107 (46%), Gaps = 4/107 (3%)
Query: 130 NLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYI 189
NLR T P + Q++ I +T + +K +++ L+ L D P + S +
Sbjct: 104 NLRYSTFPLLWQAQKF----INYPDTLVSSTVKVIILSLSKLFDIPQDGVALTQSIIKQE 159
Query: 190 HRQLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLV 236
++ ++ F N L+L P H+++ L +A V ++ + E L+
Sbjct: 160 NKSIKKFKNYLTLSPFCLAYQKYVHQMKCLLPNLAQVKSQDQLEDLI 206
>UniRef50_Q59294 Cluster: Porphyrin biosynthesis protein hemD
[Includes: Uroporphyrinogen-III C- methyltransferase (EC
2.1.1.107) (Urogen III methylase) (SUMT)
(Uroporphyrinogen III methylase) (UROM);
Uroporphyrinogen-III synthase (EC 4.2.1.75) (UROS)
(Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane
hydrolyase [cyclizing])]; n=3; Clostridium|Rep:
Porphyrin biosynthesis protein hemD [Includes:
Uroporphyrinogen-III C- methyltransferase (EC 2.1.1.107)
(Urogen III methylase) (SUMT) (Uroporphyrinogen III
methylase) (UROM); Uroporphyrinogen-III synthase (EC
4.2.1.75) (UROS) (Uroporphyrinogen-III cosynthetase)
(Hydroxymethylbilane hydrolyase [cyclizing])] -
Clostridium josui
Length = 504
Score = 35.5 bits (78), Expect = 1.3
Identities = 38/170 (22%), Positives = 71/170 (41%), Gaps = 7/170 (4%)
Query: 73 VIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLR 132
V+ N+K + TVG +++ +K + +L+ I + + L +
Sbjct: 333 VLANTK-IGTVGSQTAKALKEVGLISDFTPEIFDGRHLALGIAERVGENEKVLICDAAIA 391
Query: 133 SETIPNMLQSEGITLDAITVYETQE-NENLKALLMELNNLNDSPSGLAFFSPSGCEYIHR 191
S+ I N+L+S I D + +Y T NEN + + ++ + F S S E
Sbjct: 392 SDDIVNILRSNNIKFDRVPLYNTNYINENSNKVKKSI--VHGELKYITFTSASTVEGFIA 449
Query: 192 QLQTFSNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLK 241
++ L L IGN TA + + VA K +S+++ +L+
Sbjct: 450 SMKDIP--LESLTAVCIGNKTAEAAKKYNLRYV-VAEKSTIDSMIDKLLE 496
>UniRef50_Q8TV50 Cluster: Uroporphyrinogen-III synthase; n=1;
Methanopyrus kandleri|Rep: Uroporphyrinogen-III synthase
- Methanopyrus kandleri
Length = 228
Score = 35.1 bits (77), Expect = 1.7
Identities = 29/152 (19%), Positives = 69/152 (45%), Gaps = 7/152 (4%)
Query: 3 IVLFKGESEDYQRIFRENNFETIFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRAVEA 62
+V G + + F++ + + V P++ + ++ ++S LL ++YD + TSPR VE
Sbjct: 5 VVRAPGLERETVQAFKKVDLDAEVVCPVELVSLDRPKISAGLL-SEYDAVAFTSPRTVEF 63
Query: 63 VSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTS 122
+S+ + K + + D+ VG + + ++ L+ ++ ++
Sbjct: 64 LSE--EEVKELRRSDVDIAAVGPRTREALERAGLRVDVMPTEYTTGKLA----EELRQYG 117
Query: 123 TFLFPCGNLRSETIPNMLQSEGITLDAITVYE 154
L R+E + L+S G+ + + +Y+
Sbjct: 118 AVLALRSRRRTEDLRRTLESYGVKAEELEMYD 149
>UniRef50_Q11DF2 Cluster: Uroporphyrinogen III synthase HEM4; n=1;
Mesorhizobium sp. BNC1|Rep: Uroporphyrinogen III
synthase HEM4 - Mesorhizobium sp. (strain BNC1)
Length = 232
Score = 34.7 bits (76), Expect = 2.2
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 1/75 (1%)
Query: 81 YTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNML 140
+ VGE ++Q + +A+ L++ I+ + S L CG +R T+ + L
Sbjct: 77 FAVGERTAQ-VAAEAGVSVKDAGAGDADRLAERIVASVQPGSKILLLCGRIRRGTLESRL 135
Query: 141 QSEGITLDAITVYET 155
+ G+ + AI Y+T
Sbjct: 136 AAAGLPVRAIETYDT 150
>UniRef50_Q0EVH9 Cluster: Uroporphyrin-III C-methyltransferase; n=2;
Thermoanaerobacter ethanolicus|Rep: Uroporphyrin-III
C-methyltransferase - Thermoanaerobacter ethanolicus
X514
Length = 497
Score = 34.3 bits (75), Expect = 2.9
Identities = 29/110 (26%), Positives = 48/110 (43%), Gaps = 4/110 (3%)
Query: 139 MLQSEG--ITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTF 196
+L+S G + I Y+ + N +K L ++ L F S S Y+H+ +
Sbjct: 390 LLESLGNCANVQKIVAYKNEPNYEIKEKL--ISELRKGIDIAVFTSSSTFNYMHQLIGDE 447
Query: 197 SNRLSLLPHFAIGNSTAHKIENLGVEIAGVAAKPKAESLVESVLKYFALQ 246
N L AIG T IE+ G + + ++ E L+E +LK + Q
Sbjct: 448 INLLKNSKIAAIGPVTKKAIEDKGFNVDIMPSEYTTEKLIEEILKNYQNQ 497
>UniRef50_Q0UYR9 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Phaeosphaeria nodorum (Septoria nodorum)
Length = 311
Score = 34.3 bits (75), Expect = 2.9
Identities = 40/163 (24%), Positives = 68/163 (41%), Gaps = 24/163 (14%)
Query: 49 YDGMILTSPRAVEAVS-------KCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXX-XX 100
Y +I TS RAVEA + K + ++ +S +Y VG +++ ++
Sbjct: 76 YGALIFTSQRAVEAFADIVEELRKAGNHVDDLLPDSLPLYVVGPATARGLRSLDLKCPIL 135
Query: 101 XXXXXNAENLSKIILKDKKKT------STFLFPCGNLRSETIPNMLQSEGI------TLD 148
N E L+ +L+ + LF G+ R + IP LQ+E + +D
Sbjct: 136 GDETGNGEALATYMLEHYNNLYPGAGKPSLLFLVGDKRRDIIPKTLQAEELGDERRCRVD 195
Query: 149 AITVYETQENENLKALLMELNNLNDSP----SGLAFFSPSGCE 187
+ +YET E ++ K L N + FSP+GC+
Sbjct: 196 ELVIYETGEMQSFKEEFSTLWRKNADAGCERQWVVVFSPTGCK 238
>UniRef50_Q24N38 Cluster: Putative anaerobic dehydrogenase; n=1;
Desulfitobacterium hafniense Y51|Rep: Putative anaerobic
dehydrogenase - Desulfitobacterium hafniense (strain
Y51)
Length = 724
Score = 33.9 bits (74), Expect = 3.8
Identities = 12/31 (38%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 49 YDGMILTSPRAVEAVSKCWDPTKFVI-WNSK 78
+ G +++SPRAV+ +CWD KF + W +
Sbjct: 453 FKGRVISSPRAVDPPGECWDDWKFFLEWGKR 483
>UniRef50_A6DCE0 Cluster: Uroporphyrinogen-III synthetase; n=1;
Caminibacter mediatlanticus TB-2|Rep:
Uroporphyrinogen-III synthetase - Caminibacter
mediatlanticus TB-2
Length = 213
Score = 33.9 bits (74), Expect = 3.8
Identities = 46/170 (27%), Positives = 70/170 (41%), Gaps = 14/170 (8%)
Query: 15 RIFRENNFETIFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVI 74
RI+ NN + VE + I+ L + ++ D +I TS AV + D
Sbjct: 2 RIYLLNNEKYEGVE--NYPVISFSPLISSIEFDNIDYLIFTSKNAVRITNAIIDE----- 54
Query: 75 WNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSE 134
W +G+ ++ +IK E L+K I K K TFL+ LR +
Sbjct: 55 WKKIPTIAIGKATANEIKHLGGSVEYQSNSGYGEELAKEIDKIYKN-KTFLW----LRPK 109
Query: 135 TIPNMLQS--EGITLDAITVYETQENENLKALLMELNNLNDSPSGLAFFS 182
+ L+ + TL I VYET N+ K L+ + SPS + FS
Sbjct: 110 KVVTNLKEYIKNNTLIEIIVYETICNKPNKKLIKPAIVIFTSPSTVKCFS 159
>UniRef50_Q2B6K9 Cluster: Uroporphyrinogen-III synthetase; n=1;
Bacillus sp. NRRL B-14911|Rep: Uroporphyrinogen-III
synthetase - Bacillus sp. NRRL B-14911
Length = 259
Score = 33.5 bits (73), Expect = 5.1
Identities = 47/194 (24%), Positives = 71/194 (36%), Gaps = 9/194 (4%)
Query: 49 YDGMILTSPRAVEA-VSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNA 107
YD +I TS A+E +S F + +G + + + A
Sbjct: 63 YDWVIFTSKNALETFISFAGRNAVF-----PKIAAIGTKTERAAEESGLAVSFTPEEFAA 117
Query: 108 ENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLME 167
E L +K L P GN I + L+ G I +YET E+ L
Sbjct: 118 EGFIDEFLPFVEKGMKVLIPKGNKARSYIADELKRAGAEPQEIIIYETGFPEDSGEKLAV 177
Query: 168 LNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHF--AIGNSTAHKIENLGVEIAG 225
+ N S LAF SPS E+ ++ ++ IG T + E LG+ +
Sbjct: 178 MLK-NGSLDVLAFTSPSTVEHFMEIVRKTGAEAAIKGCLVACIGPVTQKRAEELGLGVHV 236
Query: 226 VAAKPKAESLVESV 239
V A E L +S+
Sbjct: 237 VPAGYTIEDLAKSI 250
>UniRef50_Q1YDX2 Cluster: Putative uroporphyrinogen-III synthase;
n=1; Aurantimonas sp. SI85-9A1|Rep: Putative
uroporphyrinogen-III synthase - Aurantimonas sp.
SI85-9A1
Length = 229
Score = 33.5 bits (73), Expect = 5.1
Identities = 27/109 (24%), Positives = 48/109 (44%), Gaps = 8/109 (7%)
Query: 48 DYDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNA 107
D+ + TS RAV A++K + + + V+ VGE + + A
Sbjct: 43 DFAALAATSMRAVPALAKVFSG------DGRPVFAVGERTGSAL-LAAGFTDVRVAAGEA 95
Query: 108 ENLSKIILK-DKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYET 155
E+++++ +T+T L+ G R+ T+ L + GI VYET
Sbjct: 96 EDIARLARDAGLGETATILYAAGRPRTGTLETALTAAGIGCHVWEVYET 144
>UniRef50_Q8XKG5 Cluster: Uroporphyrinogen III methylase; n=12;
Clostridium|Rep: Uroporphyrinogen III methylase -
Clostridium perfringens
Length = 492
Score = 33.1 bits (72), Expect = 6.7
Identities = 27/121 (22%), Positives = 48/121 (39%), Gaps = 3/121 (2%)
Query: 36 NIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVIWNSK-DVYTVGEMSSQKIKXX 94
N++E L YD ++ TS AV + I K D +G+ + + +
Sbjct: 290 NLDEYINTL--EKYDHIVFTSVNAVNVFFDYLVKNRVDIRKIKADFAVLGKATKKALISR 347
Query: 95 XXXXXXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYE 154
AE L +++ + K+ L PC +L E + + L S G + +Y+
Sbjct: 348 GIVPSIMAHSFTAEGLFEVLKDNIKEGEEVLIPCSSLSREYLFDNLASLGAKCHRVNIYD 407
Query: 155 T 155
T
Sbjct: 408 T 408
>UniRef50_A4SX03 Cluster: FAD-dependent pyridine
nucleotide-disulphide oxidoreductase; n=60;
Proteobacteria|Rep: FAD-dependent pyridine
nucleotide-disulphide oxidoreductase - Polynucleobacter
sp. QLW-P1DMWA-1
Length = 413
Score = 33.1 bits (72), Expect = 6.7
Identities = 17/54 (31%), Positives = 30/54 (55%)
Query: 150 ITVYETQENENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLL 203
++ YE ++ NLK + +ELNN + G+A F P EY+ + T + +L+
Sbjct: 177 LSCYEWEKQGNLKNIEVELNNAGAALFGVADFVPPLMEYVKKYNATLNFNCNLV 230
>UniRef50_Q943R3 Cluster: Calmodulin-binding protein-like; n=2;
Oryza sativa|Rep: Calmodulin-binding protein-like -
Oryza sativa subsp. japonica (Rice)
Length = 438
Score = 33.1 bits (72), Expect = 6.7
Identities = 13/53 (24%), Positives = 31/53 (58%)
Query: 23 ETIFVEPLQFIYINIEELSQKLLQNDYDGMILTSPRAVEAVSKCWDPTKFVIW 75
E + V+ +Q +++ +E L ++++Q + ++ SPR +E +S P + +W
Sbjct: 33 EALMVKQMQTLFVALEPLLRRVVQEELQAGLVRSPRYIERMSPETPPAQPPMW 85
>UniRef50_Q86EY4 Cluster: Clone ZZD1296 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1296 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 300
Score = 33.1 bits (72), Expect = 6.7
Identities = 17/66 (25%), Positives = 38/66 (57%), Gaps = 1/66 (1%)
Query: 110 LSKIILKDKKKTSTFLF-PCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMEL 168
L+K+I++D + +F N S+++ N+ +EG++LD+++ + + EN+ E+
Sbjct: 134 LNKLIVEDAARQKQAIFHKTSNRTSDSLSNVKSTEGVSLDSLSDEDIKNVENISPQHQEI 193
Query: 169 NNLNDS 174
+ DS
Sbjct: 194 ISKIDS 199
>UniRef50_A2FEK1 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 1018
Score = 33.1 bits (72), Expect = 6.7
Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 1/87 (1%)
Query: 159 ENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKIEN 218
E +++L+ + D + P YI + L FS+ + LLP FA +++A + N
Sbjct: 498 EAMQSLVSLYRTIIDVYQNILSLDPIENCYIQKSLMNFSSTIKLLP-FADSSTSASQFFN 556
Query: 219 LGVEIAGVAAKPKAESLVESVLKYFAL 245
L + G + LV ++K+F L
Sbjct: 557 LLAQDEGAYPIRNSNDLVCFIMKHFIL 583
>UniRef50_A7DLH1 Cluster: Uroporphyrinogen-III synthase; n=2;
Methylobacterium extorquens PA1|Rep:
Uroporphyrinogen-III synthase - Methylobacterium
extorquens PA1
Length = 236
Score = 32.7 bits (71), Expect = 8.9
Identities = 41/192 (21%), Positives = 73/192 (38%), Gaps = 12/192 (6%)
Query: 49 YDGMILTSPRAVEAVSKCWDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXXXNAE 108
+DG+ILTS A ++ P V+ VG ++++ + +A
Sbjct: 46 FDGLILTSANAAAPLAAAGLP-------EAPVFAVGTRTAERAERAGLRSVHCADG-DAV 97
Query: 109 NLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENL-KALLME 167
+L++++ + T L G R L + G + T Y L + ++
Sbjct: 98 SLARLVAAHVRPGGTLLHAAGEDRKAEPAASLTAAGYGVTTWTAYAALAEATLPEPVVQG 157
Query: 168 LNNLNDSPSGLAF-FSPSGCEY-IHRQLQT-FSNRLSLLPHFAIGNSTAHKIENLGVEIA 224
L + +P A FS E +H + L H+ + A + LGV
Sbjct: 158 LMGRDGAPLAAALHFSRRSAEIAVHLSGKAGLGGAFRALAHYCLSPDVALGLVELGVAAH 217
Query: 225 GVAAKPKAESLV 236
VAA+P E+L+
Sbjct: 218 FVAARPSEEALL 229
>UniRef50_A3V904 Cluster: Phage integrase; n=4; Loktanella
vestfoldensis SKA53|Rep: Phage integrase - Loktanella
vestfoldensis SKA53
Length = 445
Score = 32.7 bits (71), Expect = 8.9
Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 2/74 (2%)
Query: 2 KIVLFKGESEDYQRIFRENNFETIFV--EPLQFIYINIEELSQKLLQNDYDGMILTSPRA 59
KI G R+ +ENN + +V E L +Y ++E K+LQ+ ++LT R
Sbjct: 185 KIAGVTGNPTHGVRLLKENNQKERYVRAEELALLYRAVKESQNKMLQHIVAFLLLTGTRR 244
Query: 60 VEAVSKCWDPTKFV 73
E + W+ +
Sbjct: 245 NEVLHATWEDVDLI 258
>UniRef50_Q82DM5 Cluster: Adenylate kinase; n=8; Bacteria|Rep:
Adenylate kinase - Streptomyces avermitilis
Length = 220
Score = 32.7 bits (71), Expect = 8.9
Identities = 18/49 (36%), Positives = 27/49 (55%)
Query: 126 FPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKALLMELNNLNDS 174
FP ++E + ML+SEG+ LDA+ E E+E +K + NDS
Sbjct: 86 FPRNVKQAEALDEMLKSEGMKLDAVLDLEVPEDEVVKRIAGRRICRNDS 134
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.316 0.133 0.374
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 240,071,049
Number of Sequences: 1657284
Number of extensions: 8868900
Number of successful extensions: 24090
Number of sequences better than 10.0: 77
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 23992
Number of HSP's gapped (non-prelim): 86
length of query: 248
length of database: 575,637,011
effective HSP length: 99
effective length of query: 149
effective length of database: 411,565,895
effective search space: 61323318355
effective search space used: 61323318355
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 71 (32.7 bits)
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