Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000197-TA|BGIBMGA000197-PA|IPR003754|Uroporphyrinogen
III synthase HEM4
(248 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
J03824-1|AAA60273.1| 265|Homo sapiens UROS protein. 124 2e-28
BC002573-1|AAH02573.1| 265|Homo sapiens uroporphyrinogen III sy... 124 2e-28
AL360176-2|CAI12087.1| 265|Homo sapiens uroporphyrinogen III sy... 124 2e-28
AF230665-1|AAG36795.1| 265|Homo sapiens uroporphyrinogen III sy... 124 2e-28
AL360176-3|CAI12088.1| 185|Homo sapiens uroporphyrinogen III sy... 100 1e-20
AL360176-5|CAI12090.1| 133|Homo sapiens uroporphyrinogen III sy... 55 3e-07
AL360176-4|CAI12089.1| 139|Homo sapiens uroporphyrinogen III sy... 54 4e-07
AK128044-1|BAC87247.1| 1135|Homo sapiens protein ( Homo sapiens ... 31 3.8
AK022533-1|BAB14082.1| 1079|Homo sapiens protein ( Homo sapiens ... 31 3.8
AC012442-2|AAX81999.1| 1135|Homo sapiens unknown protein. 31 3.8
BT006642-1|AAP35288.1| 459|Homo sapiens zinc finger protein 259... 31 5.0
BC111028-1|AAI11029.1| 459|Homo sapiens zinc finger protein 259... 31 5.0
BC017380-1|AAH17380.1| 459|Homo sapiens zinc finger protein 259... 31 5.0
BC017349-1|AAH17349.1| 459|Homo sapiens zinc finger protein 259... 31 5.0
BC012162-1|AAH12162.1| 459|Homo sapiens zinc finger protein 259... 31 5.0
BC004256-1|AAH04256.1| 459|Homo sapiens zinc finger protein 259... 31 5.0
AF019767-1|AAC33514.1| 459|Homo sapiens zinc finger protein pro... 31 5.0
>J03824-1|AAA60273.1| 265|Homo sapiens UROS protein.
Length = 265
Score = 124 bits (300), Expect = 2e-28
Identities = 78/258 (30%), Positives = 123/258 (47%), Gaps = 18/258 (6%)
Query: 1 MKIVLFKGESED------YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMI 53
MK++L K ED Y R E + L F ++++ S+KL DY G+I
Sbjct: 1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 60
Query: 54 LTSPRAVEAVSKC---------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXX 104
TSPRAVEA C W+ + WN+K VY VG ++ +
Sbjct: 61 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 120
Query: 105 XNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKAL 164
NAE L++ I + LFPCGNL+ E +P L+ +GI +++ITVY+T + ++
Sbjct: 121 -NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGN 179
Query: 165 LMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFS-NRLSLLPHFAIGNSTAHKIENLGVEI 223
L + P+ + FFSPSG Y + +Q S + + + AIG +TA + G+ +
Sbjct: 180 LNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPV 239
Query: 224 AGVAAKPKAESLVESVLK 241
+ A P ++L + K
Sbjct: 240 SCTAESPTPQALATGIRK 257
>BC002573-1|AAH02573.1| 265|Homo sapiens uroporphyrinogen III
synthase (congenital erythropoietic porphyria) protein.
Length = 265
Score = 124 bits (300), Expect = 2e-28
Identities = 78/258 (30%), Positives = 123/258 (47%), Gaps = 18/258 (6%)
Query: 1 MKIVLFKGESED------YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMI 53
MK++L K ED Y R E + L F ++++ S+KL DY G+I
Sbjct: 1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 60
Query: 54 LTSPRAVEAVSKC---------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXX 104
TSPRAVEA C W+ + WN+K VY VG ++ +
Sbjct: 61 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 120
Query: 105 XNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKAL 164
NAE L++ I + LFPCGNL+ E +P L+ +GI +++ITVY+T + ++
Sbjct: 121 -NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGN 179
Query: 165 LMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFS-NRLSLLPHFAIGNSTAHKIENLGVEI 223
L + P+ + FFSPSG Y + +Q S + + + AIG +TA + G+ +
Sbjct: 180 LNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPV 239
Query: 224 AGVAAKPKAESLVESVLK 241
+ A P ++L + K
Sbjct: 240 SCTAESPTPQALATGIRK 257
>AL360176-2|CAI12087.1| 265|Homo sapiens uroporphyrinogen III
synthase (congenital erythropoietic porphyria) protein.
Length = 265
Score = 124 bits (300), Expect = 2e-28
Identities = 78/258 (30%), Positives = 123/258 (47%), Gaps = 18/258 (6%)
Query: 1 MKIVLFKGESED------YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMI 53
MK++L K ED Y R E + L F ++++ S+KL DY G+I
Sbjct: 1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 60
Query: 54 LTSPRAVEAVSKC---------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXX 104
TSPRAVEA C W+ + WN+K VY VG ++ +
Sbjct: 61 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 120
Query: 105 XNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKAL 164
NAE L++ I + LFPCGNL+ E +P L+ +GI +++ITVY+T + ++
Sbjct: 121 -NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGN 179
Query: 165 LMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFS-NRLSLLPHFAIGNSTAHKIENLGVEI 223
L + P+ + FFSPSG Y + +Q S + + + AIG +TA + G+ +
Sbjct: 180 LNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPV 239
Query: 224 AGVAAKPKAESLVESVLK 241
+ A P ++L + K
Sbjct: 240 SCTAESPTPQALATGIRK 257
>AF230665-1|AAG36795.1| 265|Homo sapiens uroporphyrinogen III
synthase protein.
Length = 265
Score = 124 bits (300), Expect = 2e-28
Identities = 78/258 (30%), Positives = 123/258 (47%), Gaps = 18/258 (6%)
Query: 1 MKIVLFKGESED------YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMI 53
MK++L K ED Y R E + L F ++++ S+KL DY G+I
Sbjct: 1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 60
Query: 54 LTSPRAVEAVSKC---------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXX 104
TSPRAVEA C W+ + WN+K VY VG ++ +
Sbjct: 61 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCG 120
Query: 105 XNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQENENLKAL 164
NAE L++ I + LFPCGNL+ E +P L+ +GI +++ITVY+T + ++
Sbjct: 121 -NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGN 179
Query: 165 LMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFS-NRLSLLPHFAIGNSTAHKIENLGVEI 223
L + P+ + FFSPSG Y + +Q S + + + AIG +TA + G+ +
Sbjct: 180 LNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPV 239
Query: 224 AGVAAKPKAESLVESVLK 241
+ A P ++L + K
Sbjct: 240 SCTAESPTPQALATGIRK 257
>AL360176-3|CAI12088.1| 185|Homo sapiens uroporphyrinogen III
synthase (congenital erythropoietic porphyria) protein.
Length = 185
Score = 99.5 bits (237), Expect = 1e-20
Identities = 54/159 (33%), Positives = 80/159 (50%), Gaps = 10/159 (6%)
Query: 48 DYDGMILTSPRAVEAVSKC---------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXX 98
DY G+I TSPRAVEA C W+ + WN+K VY VG ++ +
Sbjct: 27 DYGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDT 86
Query: 99 XXXXXXXNAENLSKIILKDKKKTSTFLFPCGNLRSETIPNMLQSEGITLDAITVYETQEN 158
NAE L++ I + LFPCGNL+ E +P L+ +GI +++ITVY+T +
Sbjct: 87 EGETCG-NAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAH 145
Query: 159 ENLKALLMELNNLNDSPSGLAFFSPSGCEYIHRQLQTFS 197
++ L + P+ + FFSPSG Y + +Q S
Sbjct: 146 PGIQGNLNSYYSQQGVPASITFFSPSGLTYSLKHIQELS 184
>AL360176-5|CAI12090.1| 133|Homo sapiens uroporphyrinogen III
synthase (congenital erythropoietic porphyria) protein.
Length = 133
Score = 54.8 bits (126), Expect = 3e-07
Identities = 41/134 (30%), Positives = 58/134 (43%), Gaps = 17/134 (12%)
Query: 1 MKIVLFKGESED------YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMI 53
MK++L K ED Y R E + L F ++++ S+KL DY G+I
Sbjct: 1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 60
Query: 54 LTSPRAVEAVSKC---------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXX 104
TSPRAVEA C W+ + WN+K VY VG ++ +
Sbjct: 61 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLV-SKIGLDTEGETC 119
Query: 105 XNAENLSKIILKDK 118
NAE L++ I K
Sbjct: 120 GNAEKLAEYICSSK 133
>AL360176-4|CAI12089.1| 139|Homo sapiens uroporphyrinogen III
synthase (congenital erythropoietic porphyria) protein.
Length = 139
Score = 54.4 bits (125), Expect = 4e-07
Identities = 41/140 (29%), Positives = 60/140 (42%), Gaps = 17/140 (12%)
Query: 1 MKIVLFKGESED------YQRIFRENNFETIFVEPLQFIYINIEELSQKLLQ-NDYDGMI 53
MK++L K ED Y R E + L F ++++ S+KL DY G+I
Sbjct: 1 MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLI 60
Query: 54 LTSPRAVEAVSKC---------WDPTKFVIWNSKDVYTVGEMSSQKIKXXXXXXXXXXXX 104
TSPRAVEA C W+ + WN+K VY VG ++ +
Sbjct: 61 FTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLV-SKIGLDTEGETC 119
Query: 105 XNAENLSKIILKDKKKTSTF 124
NAE L++ I ++ F
Sbjct: 120 GNAEKLAEYICSSEEVKGIF 139
>AK128044-1|BAC87247.1| 1135|Homo sapiens protein ( Homo sapiens
cDNA FLJ46164 fis, clone TESTI4002799, highly similar
to DNA-directed RNA polymerase I 135 kDa polypeptide (EC
2.7.7.6). ).
Length = 1135
Score = 31.1 bits (67), Expect = 3.8
Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 2/46 (4%)
Query: 106 NAENLSKIILK--DKKKTSTFLFPCGNLRSETIPNMLQSEGITLDA 149
N +NL +I D K +LF GNLRS+T +LQ G+ + A
Sbjct: 412 NTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVA 457
>AK022533-1|BAB14082.1| 1079|Homo sapiens protein ( Homo sapiens
cDNA FLJ12471 fis, clone NT2RM1000894, highly similar to
DNA-DIRECTED RNA POLYMERASE I 135 KD POLYPEPTIDE (EC
2.7.7.6). ).
Length = 1079
Score = 31.1 bits (67), Expect = 3.8
Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 2/46 (4%)
Query: 106 NAENLSKIILK--DKKKTSTFLFPCGNLRSETIPNMLQSEGITLDA 149
N +NL +I D K +LF GNLRS+T +LQ G+ + A
Sbjct: 356 NTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVA 401
>AC012442-2|AAX81999.1| 1135|Homo sapiens unknown protein.
Length = 1135
Score = 31.1 bits (67), Expect = 3.8
Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 2/46 (4%)
Query: 106 NAENLSKIILK--DKKKTSTFLFPCGNLRSETIPNMLQSEGITLDA 149
N +NL +I D K +LF GNLRS+T +LQ G+ + A
Sbjct: 412 NTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVA 457
>BT006642-1|AAP35288.1| 459|Homo sapiens zinc finger protein 259
protein.
Length = 459
Score = 30.7 bits (66), Expect = 5.0
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 159 ENLKALLMELNNLND--SPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKI 216
E + +++L L SP L PSG ++ + ++ H+ N T +
Sbjct: 173 ERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDALVITHY---NRTRQQE 229
Query: 217 ENLGVEIAGVAAKPKAESLVESVLKY 242
E LG++ A KP+ E L VL++
Sbjct: 230 EMLGLQEEAPAEKPEEEDLRNEVLQF 255
>BC111028-1|AAI11029.1| 459|Homo sapiens zinc finger protein 259
protein.
Length = 459
Score = 30.7 bits (66), Expect = 5.0
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 159 ENLKALLMELNNLND--SPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKI 216
E + +++L L SP L PSG ++ + ++ H+ N T +
Sbjct: 173 ERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDALVITHY---NRTRQQE 229
Query: 217 ENLGVEIAGVAAKPKAESLVESVLKY 242
E LG++ A KP+ E L VL++
Sbjct: 230 EMLGLQEEAPAEKPEEEDLRNEVLQF 255
>BC017380-1|AAH17380.1| 459|Homo sapiens zinc finger protein 259
protein.
Length = 459
Score = 30.7 bits (66), Expect = 5.0
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 159 ENLKALLMELNNLND--SPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKI 216
E + +++L L SP L PSG ++ + ++ H+ N T +
Sbjct: 173 ERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDALVITHY---NRTRQQE 229
Query: 217 ENLGVEIAGVAAKPKAESLVESVLKY 242
E LG++ A KP+ E L VL++
Sbjct: 230 EMLGLQEEAPAEKPEEEDLRNEVLQF 255
>BC017349-1|AAH17349.1| 459|Homo sapiens zinc finger protein 259
protein.
Length = 459
Score = 30.7 bits (66), Expect = 5.0
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 159 ENLKALLMELNNLND--SPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKI 216
E + +++L L SP L PSG ++ + ++ H+ N T +
Sbjct: 173 ERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDALVITHY---NRTRQQE 229
Query: 217 ENLGVEIAGVAAKPKAESLVESVLKY 242
E LG++ A KP+ E L VL++
Sbjct: 230 EMLGLQEEAPAEKPEEEDLRNEVLQF 255
>BC012162-1|AAH12162.1| 459|Homo sapiens zinc finger protein 259
protein.
Length = 459
Score = 30.7 bits (66), Expect = 5.0
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 159 ENLKALLMELNNLND--SPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKI 216
E + +++L L SP L PSG ++ + ++ H+ N T +
Sbjct: 173 ERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDALVITHY---NRTRQQE 229
Query: 217 ENLGVEIAGVAAKPKAESLVESVLKY 242
E LG++ A KP+ E L VL++
Sbjct: 230 EMLGLQEEAPAEKPEEEDLRNEVLQF 255
>BC004256-1|AAH04256.1| 459|Homo sapiens zinc finger protein 259
protein.
Length = 459
Score = 30.7 bits (66), Expect = 5.0
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 159 ENLKALLMELNNLND--SPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKI 216
E + +++L L SP L PSG ++ + ++ H+ N T +
Sbjct: 173 ERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDALVITHY---NRTRQQE 229
Query: 217 ENLGVEIAGVAAKPKAESLVESVLKY 242
E LG++ A KP+ E L VL++
Sbjct: 230 EMLGLQEEAPAEKPEEEDLRNEVLQF 255
>AF019767-1|AAC33514.1| 459|Homo sapiens zinc finger protein
protein.
Length = 459
Score = 30.7 bits (66), Expect = 5.0
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 159 ENLKALLMELNNLND--SPSGLAFFSPSGCEYIHRQLQTFSNRLSLLPHFAIGNSTAHKI 216
E + +++L L SP L PSG ++ + ++ H+ N T +
Sbjct: 173 ERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDALVITHY---NRTRQQE 229
Query: 217 ENLGVEIAGVAAKPKAESLVESVLKY 242
E LG++ A KP+ E L VL++
Sbjct: 230 EMLGLQEEAPAEKPEEEDLRNEVLQF 255
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.316 0.133 0.374
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 30,683,507
Number of Sequences: 224733
Number of extensions: 1088966
Number of successful extensions: 1981
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1962
Number of HSP's gapped (non-prelim): 17
length of query: 248
length of database: 73,234,838
effective HSP length: 88
effective length of query: 160
effective length of database: 53,458,334
effective search space: 8553333440
effective search space used: 8553333440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 64 (29.9 bits)
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