BLASTP 2.2.12 [Aug-07-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= BGIBMGA000138-TA|BGIBMGA000138-PA|IPR002773|Deoxyhypusine synthase (371 letters) Database: uniref50 1,657,284 sequences; 575,637,011 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value UniRef50_UPI00015B4ADD Cluster: PREDICTED: similar to deoxyhypus... 466 e-130 UniRef50_P49366 Cluster: Deoxyhypusine synthase; n=40; Eukaryota... 454 e-126 UniRef50_A7SNR4 Cluster: Predicted protein; n=5; Eumetazoa|Rep: ... 439 e-122 UniRef50_Q9FI94 Cluster: Deoxyhypusine synthase; n=17; Eukaryota... 420 e-116 UniRef50_A7AQ07 Cluster: Deoxyhypusine synthase, putative; n=1; ... 380 e-104 UniRef50_Q7QQK3 Cluster: GLP_66_24805_25974; n=1; Giardia lambli... 372 e-102 UniRef50_P38791 Cluster: Deoxyhypusine synthase; n=57; Eukaryota... 357 3e-97 UniRef50_P49366-2 Cluster: Isoform Short of P49366 ; n=21; Eutel... 322 9e-87 UniRef50_UPI0000498E3F Cluster: deoxyhypusine synthase; n=1; Ent... 301 2e-80 UniRef50_Q014Q0 Cluster: Deoxyhypusine synthase; n=1; Ostreococc... 283 4e-75 UniRef50_UPI0000499BAB Cluster: deoxyhypusine synthase; n=1; Ent... 273 6e-72 UniRef50_Q8SQN2 Cluster: Deoxyhypusine synthase; n=1; Encephalit... 259 7e-68 UniRef50_O50105 Cluster: Probable deoxyhypusine synthase; n=31; ... 243 5e-63 UniRef50_Q9HPX2 Cluster: Probable deoxyhypusine synthase; n=2; H... 215 2e-54 UniRef50_Q4QD19 Cluster: Deoxyhypusine synthase, putative; n=5; ... 197 3e-49 UniRef50_Q8MPC1 Cluster: Putative dexyhypusine synthase; n=1; Ta... 196 6e-49 UniRef50_Q9HL74 Cluster: Probable deoxyhypusine synthase; n=6; A... 190 4e-47 UniRef50_Q9GSW0 Cluster: Deoxyhypusine synthase; n=2; Plasmodium... 187 4e-46 UniRef50_Q5CHK2 Cluster: Deoxyhypusine synthase; n=1; Cryptospor... 187 4e-46 UniRef50_Q0KHM1 Cluster: Deoxyhypusine synthase; n=5; Plasmodium... 186 8e-46 UniRef50_Q0J1Q0 Cluster: Os09g0421100 protein; n=5; Oryza sativa... 185 1e-45 UniRef50_Q12UX5 Cluster: Deoxyhypusine synthase; n=1; Methanococ... 180 5e-44 UniRef50_A7DSG5 Cluster: Deoxyhypusine synthase; n=1; Candidatus... 157 4e-37 UniRef50_A4YHK6 Cluster: Deoxyhypusine synthase; n=1; Metallosph... 157 6e-37 UniRef50_Q97ZF1 Cluster: Probable deoxyhypusine synthase; n=7; T... 155 2e-36 UniRef50_Q4CSD9 Cluster: Deoxyhypusine synthase, putative; n=3; ... 143 6e-33 UniRef50_A0RUJ9 Cluster: Deoxyhypusine synthase; n=1; Cenarchaeu... 139 1e-31 UniRef50_Q8ZT09 Cluster: Probable deoxyhypusine synthase; n=5; T... 133 6e-30 UniRef50_A1RX92 Cluster: Deoxyhypusine synthase; n=1; Thermofilu... 130 8e-29 UniRef50_Q4Q3H5 Cluster: Deoxyhypusine synthase, putative; n=3; ... 104 3e-21 UniRef50_O26230 Cluster: Probable deoxyhypusine synthase; n=3; M... 97 6e-19 UniRef50_Q8PV89 Cluster: Probable deoxyhypusine synthase 1; n=10... 97 6e-19 UniRef50_Q8Q051 Cluster: Probable deoxyhypusine synthase 2; n=8;... 93 8e-18 UniRef50_O28088 Cluster: Probable deoxyhypusine synthase 1; n=1;... 93 1e-17 UniRef50_A3DLU9 Cluster: Deoxyhypusine synthase; n=1; Staphyloth... 87 7e-16 UniRef50_A0B8D8 Cluster: Deoxyhypusine synthase; n=1; Methanosae... 87 9e-16 UniRef50_Q18GE0 Cluster: Deoxyhypusine synthase; n=3; Halobacter... 84 6e-15 UniRef50_A7H9T8 Cluster: Deoxyhypusine synthase; n=2; Bacteria|R... 82 2e-14 UniRef50_Q8TXD7 Cluster: Probable deoxyhypusine synthase; n=1; M... 82 3e-14 UniRef50_UPI000065F1C0 Cluster: Deoxyhypusine synthase (EC 2.5.1... 81 3e-14 UniRef50_Q9AB72 Cluster: Deoxyhypusine synthase-like protein; n=... 64 4e-09 UniRef50_A6C8I9 Cluster: Deoxyhypusine synthase; n=1; Planctomyc... 58 3e-07 UniRef50_A0RU78 Cluster: Deoxyhypusine synthase; n=5; Crenarchae... 49 2e-04 UniRef50_Q3KTG9 Cluster: SJCHGC07653 protein; n=1; Schistosoma j... 48 5e-04 UniRef50_Q8DKP1 Cluster: Deoxyhypusine synthase-like protein; n=... 47 7e-04 UniRef50_Q1IQA7 Cluster: Deoxyhypusine synthase; n=1; Acidobacte... 42 0.020 UniRef50_Q2JJ35 Cluster: Deoxyhypusine synthase family protein; ... 38 0.32 UniRef50_Q8RBX9 Cluster: Putative uncharacterized protein; n=6; ... 38 0.56 UniRef50_Q20103 Cluster: Putative uncharacterized protein; n=3; ... 37 0.97 UniRef50_A0LN06 Cluster: Deoxyhypusine synthase; n=1; Syntrophob... 36 1.7 UniRef50_Q09DI8 Cluster: Cardb domain protein; n=3; Bacteria|Rep... 36 2.2 UniRef50_Q09A08 Cluster: Deoxyhypusine synthase; n=3; Cystobacte... 35 3.9 UniRef50_Q9FLA5 Cluster: Gb|AAC61825.1; n=3; core eudicotyledons... 34 5.2 UniRef50_Q9PQB4 Cluster: DNA polymerase III polC-type; n=1; Urea... 34 5.2 UniRef50_Q9U0N4 Cluster: ABC transporter, putative; n=2; Plasmod... 34 6.9 UniRef50_Q4S833 Cluster: Chromosome 9 SCAF14710, whole genome sh... 33 9.1 UniRef50_Q029V5 Cluster: Deoxyhypusine synthase; n=1; Solibacter... 33 9.1 UniRef50_A4QSG6 Cluster: Putative uncharacterized protein; n=1; ... 33 9.1 >UniRef50_UPI00015B4ADD Cluster: PREDICTED: similar to deoxyhypusine synthase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar to deoxyhypusine synthase - Nasonia vitripennis Length = 521 Score = 466 bits (1148), Expect = e-130 Identities = 210/341 (61%), Positives = 264/341 (77%), Gaps = 1/341 (0%) Query: 15 PNIAVNAVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNM 74 P +N VL+ S LP+ TP V GYD+ +G +Y+ + SY +SGFQATNFG V EI M Sbjct: 130 PESLINNVLKHSAPLPSTTPTVKGYDFNDGINYSALFRSYKHSGFQATNFGLAVEEILRM 189 Query: 75 LKSRAVPLTEENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIV 134 L +R +PL E+ D EED+FI+++ CTIFLGYTSNM S G+R+TIRFL +++++D IV Sbjct: 190 LVARRIPLEEDQEDNLEEDEFIRRRHGCTIFLGYTSNMASCGVRETIRFLAEHRMIDCIV 249 Query: 135 TTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDE 194 TTAGG+EED IKC+APTYVGDF+L GK LR +GINRIGNLLVPNDNYCLFE+WV P+LD+ Sbjct: 250 TTAGGVEEDFIKCLAPTYVGDFHLDGKTLRDKGINRIGNLLVPNDNYCLFEDWVMPILDK 309 Query: 195 MISEQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHS 254 M+ EQ K+G +W+PS++ ARLGE INN S+ YWA +N IP+FSPALTDGSLGDMMYFHS Sbjct: 310 MLEEQ-KKGVLWTPSKVIARLGEEINNRDSIYYWAAKNKIPVFSPALTDGSLGDMMYFHS 368 Query: 255 FKRPXXXXXXXXXXXXXNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTA 314 FK P NT+A+KA +GV KHHICNANLMRNGAD+ V++NTA Sbjct: 369 FKNPGLVVDIVSDLRRLNTIAMKAIRSGVIIIGGGVVKHHICNANLMRNGADFGVFLNTA 428 Query: 315 SEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLI 355 SE+DGSD+GARPDEAVSWGKIR ++ VK++A+A+LVFPL+ Sbjct: 429 SEYDGSDSGARPDEAVSWGKIRKDSKAVKIFAEASLVFPLL 469 >UniRef50_P49366 Cluster: Deoxyhypusine synthase; n=40; Eukaryota|Rep: Deoxyhypusine synthase - Homo sapiens (Human) Length = 369 Score = 454 bits (1120), Expect = e-126 Identities = 207/349 (59%), Positives = 267/349 (76%) Query: 14 APNIAVNAVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINN 73 AP A+ AVL+ S LP E+ V GYD+ G +Y +LE++ +GFQATNFG+ V ++N Sbjct: 9 APAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNA 68 Query: 74 MLKSRAVPLTEENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVI 133 M++ + PL+++ + Q + T+CTIFLGYTSN+ISSG+R+TIR+LV++ +VDV+ Sbjct: 69 MIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDVL 128 Query: 134 VTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLD 193 VTTAGG+EEDLIKC+APTY+G+F+L GK LR GINRIGNLLVPN+NYC FE+W+ P+LD Sbjct: 129 VTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFEDWLMPILD 188 Query: 194 EMISEQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFH 253 +M+ EQ EG W+PS++ ARLG+ INN SV YWA +N+IP+FSPALTDGSLGDM++FH Sbjct: 189 QMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGSLGDMIFFH 248 Query: 254 SFKRPXXXXXXXXXXXXXNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNT 313 S+K P NT A+ A TG+ KHHI NANLMRNGADYAVY+NT Sbjct: 249 SYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINT 308 Query: 314 ASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVAQTFAK 362 A EFDGSD+GARPDEAVSWGKIR +A PVK+YADA+LVFPL+VA+TFA+ Sbjct: 309 AQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQ 357 >UniRef50_A7SNR4 Cluster: Predicted protein; n=5; Eumetazoa|Rep: Predicted protein - Nematostella vectensis Length = 366 Score = 439 bits (1082), Expect = e-122 Identities = 199/355 (56%), Positives = 264/355 (74%), Gaps = 3/355 (0%) Query: 15 PNIAVNAVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNM 74 P IAV++VL S+ +P + V GYD+ GTDY+ +L+SY N+GFQA +FGK V EIN M Sbjct: 9 PQIAVDSVLLKSEPMPDGSETVKGYDFNQGTDYHALLQSYKNTGFQAMHFGKAVDEINKM 68 Query: 75 LKSRAVPLTEENSDCYEEDQFI--KKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDV 132 + + P N++ E D + K NCTIFL YTSNMIS G+R+ IR+LV+N +VDV Sbjct: 69 IAKKKEPYVP-NTENPELDILPTGRPKNNCTIFLAYTSNMISCGVREVIRYLVQNNMVDV 127 Query: 133 IVTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLL 192 +VTT GGIEED +KC+AP+Y+GDF++SG+ LR +GINRIGNLLVPNDNYC E+++ P+L Sbjct: 128 LVTTGGGIEEDFMKCLAPSYLGDFSISGEFLRKKGINRIGNLLVPNDNYCKLEDFIQPVL 187 Query: 193 DEMISEQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYF 252 D+M+ EQ EG W+PS+ ARLG+ IN+ SV YWA++NNIP+FSPA+TDG++GD +YF Sbjct: 188 DKMLEEQQNEGINWTPSKFIARLGKEINHPESVYYWAYKNNIPVFSPAITDGAIGDAIYF 247 Query: 253 HSFKRPXXXXXXXXXXXXXNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVN 312 HS++ P N AV + NTG+ KHH+CNAN+MRNGADYAVYVN Sbjct: 248 HSYRNPGLKLDIAEDVRLVNNHAVFSKNTGIIILGGGLVKHHVCNANMMRNGADYAVYVN 307 Query: 313 TASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVAQTFAKHHFSS 367 TA EFDGSD+GARPDEAVSWGKI+ A PVK+Y +++L+FPL+VA+TFA++ S+ Sbjct: 308 TAQEFDGSDSGARPDEAVSWGKIKATATPVKIYGESSLIFPLLVAETFARNFKST 362 >UniRef50_Q9FI94 Cluster: Deoxyhypusine synthase; n=17; Eukaryota|Rep: Deoxyhypusine synthase - Arabidopsis thaliana (Mouse-ear cress) Length = 368 Score = 420 bits (1035), Expect = e-116 Identities = 191/346 (55%), Positives = 248/346 (71%), Gaps = 4/346 (1%) Query: 20 NAVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKSRA 79 + V + S+ L + + GYD+ G DY K++ S +GFQA+N G+ + +N ML R Sbjct: 12 STVFKESESLEGKCDKIEGYDFNQGVDYPKLMRSMLTTGFQASNLGEAIDVVNQMLDWRL 71 Query: 80 VPLTEENSDCYEEDQ--FIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTA 137 T DC EE++ ++ C IFLG+TSN++SSG+RDTIR+LV++ +VDVIVTT Sbjct: 72 ADETTVAEDCSEEEKNPSFRESVKCKIFLGFTSNLVSSGVRDTIRYLVQHHMVDVIVTTT 131 Query: 138 GGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMIS 197 GG+EEDLIKC+APT+ GDF+L G LR++G+NRIGNLLVPNDNYC FE+W+ P+ DEM+ Sbjct: 132 GGVEEDLIKCLAPTFKGDFSLPGAYLRSKGLNRIGNLLVPNDNYCKFEDWIIPIFDEMLK 191 Query: 198 EQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKR 257 EQ +E +W+PS++ ARLG+ INNESS YWA++ NIP+F P LTDGSLGDM+YFHSF+ Sbjct: 192 EQKEENVLWTPSKLLARLGKEINNESSYLYWAYKMNIPVFCPGLTDGSLGDMLYFHSFRT 251 Query: 258 PXXXXXXXXXXXXXNTMAVKAN--NTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTAS 315 N AV AN TG+ KHHICNAN+MRNGADYAV++NT Sbjct: 252 SGLIIDVVQDIRAMNGEAVHANPKKTGMIILGGGLPKHHICNANMMRNGADYAVFINTGQ 311 Query: 316 EFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVAQTFA 361 EFDGSD+GARPDEAVSWGKIR +A VK+Y DAT+ FPL+VA+TFA Sbjct: 312 EFDGSDSGARPDEAVSWGKIRGSAKTVKVYCDATIAFPLLVAETFA 357 >UniRef50_A7AQ07 Cluster: Deoxyhypusine synthase, putative; n=1; Babesia bovis|Rep: Deoxyhypusine synthase, putative - Babesia bovis Length = 370 Score = 380 bits (934), Expect = e-104 Identities = 176/355 (49%), Positives = 239/355 (67%), Gaps = 7/355 (1%) Query: 15 PNIAVNAVLQPSQDLPAETPI-VAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINN 73 P++A AVLQPS LP + V G +++ ++L Y N GFQAT+ G+ I+ Sbjct: 12 PDVAAKAVLQPSS-LPKDCEAYVEGIHYDHDISIEELLAIYKNFGFQATHLGQAAEMIDR 70 Query: 74 MLKSRAV--PLTEENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVD 131 MLK R + P++E++ ED ++K T CTI+L +TSNMIS GLRD +L K+KL+D Sbjct: 71 MLKYRLIDDPVSEDDIGSKYEDPEVRKSTKCTIWLAFTSNMISCGLRDAFVYLAKHKLID 130 Query: 132 VIVTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPL 191 V+VT+ GG+EEDLIKC+ TY+G FN+ G +R G+NRIGNL +PNDNYC FE W+ P Sbjct: 131 VVVTSGGGVEEDLIKCMGKTYIGRFNMDGATMRESGLNRIGNLFIPNDNYCDFETWLQPR 190 Query: 192 LDEMISEQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMY 251 LDEM +Q ++G W+PS LG+ IN+E+S CYW +N IP+F P +TDGS+GD +Y Sbjct: 191 LDEMHRQQTEDGVSWTPSTFIDFLGKEINDETSFCYWCHKNQIPVFCPGITDGSIGDNLY 250 Query: 252 FHSFKRPXXXX---XXXXXXXXXNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYA 308 FH++ + N +AV + +G+ KHH+CNANLMRNGAD+A Sbjct: 251 FHTYSKSSPTTLKIDVVRDIRRVNDIAVHSKKSGIIILGGGLAKHHVCNANLMRNGADFA 310 Query: 309 VYVNTASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVAQTFAKH 363 VY++TA EFDGSD+GA PDEAVSWGKI+ NPVK++ADA+LVFPL+VA F K+ Sbjct: 311 VYISTAQEFDGSDSGANPDEAVSWGKIKAYTNPVKVHADASLVFPLLVAGVFRKY 365 >UniRef50_Q7QQK3 Cluster: GLP_66_24805_25974; n=1; Giardia lamblia ATCC 50803|Rep: GLP_66_24805_25974 - Giardia lamblia ATCC 50803 Length = 389 Score = 372 bits (915), Expect = e-102 Identities = 173/316 (54%), Positives = 219/316 (69%), Gaps = 2/316 (0%) Query: 50 ILESYANSGFQATNFGKTVVEINNMLKSRAVPLTEENSDCYEEDQFIKKKTNCTIFLGYT 109 IL +YA GF +T F K E+N M R + + Y E + K C +FLGYT Sbjct: 42 ILSNYARIGFSSTGFSKLCTEVNRMYSWRLSDDPYDPNRSYPECPIARSKIRCKVFLGYT 101 Query: 110 SNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGIN 169 SN++SSGLR+ IRFLV++ LVDVIVT+AGG+EED+IKC+APTY+GD+ G +LR IN Sbjct: 102 SNLVSSGLREYIRFLVQHSLVDVIVTSAGGVEEDIIKCLAPTYLGDWKTDGAMLRKNSIN 161 Query: 170 RIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINNESSVCYWA 229 RIGNLLVPNDNYCLFE+W+ P+ DE + EQ ++G W+PSR+ +LG+RIN+E S+ YWA Sbjct: 162 RIGNLLVPNDNYCLFEDWIIPIFDECV-EQQRKGYHWTPSRLIWKLGKRINDERSIAYWA 220 Query: 230 WRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVKANNTGVXXXXXX 289 +RN IPIF PA+TDGSLGDM++FHS+K P N A+ + G Sbjct: 221 YRNKIPIFCPAITDGSLGDMLFFHSYKNPGLIIDVVGDIRAMNMQAINSPKNGCIILGSG 280 Query: 290 XXKHHICNANLMR-NGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADA 348 KHHI NANL +GAD+AVY+NTA E+DGSDAGA DEAVSWGKI P A PVKL ADA Sbjct: 281 TIKHHILNANLFAGDGADFAVYINTAQEYDGSDAGATCDEAVSWGKISPTARPVKLCADA 340 Query: 349 TLVFPLIVAQTFAKHH 364 TLVFPL++ +T K + Sbjct: 341 TLVFPLLLHETILKKY 356 >UniRef50_P38791 Cluster: Deoxyhypusine synthase; n=57; Eukaryota|Rep: Deoxyhypusine synthase - Saccharomyces cerevisiae (Baker's yeast) Length = 387 Score = 357 bits (877), Expect = 3e-97 Identities = 185/373 (49%), Positives = 245/373 (65%), Gaps = 30/373 (8%) Query: 15 PNIAVNAVLQPSQDLPAETPIVAGYDWENGTDYNK----ILESYANSGFQATNFGKTVVE 70 P + +AVL+ S +P + V G D+ N ++E+ GFQA++ G Sbjct: 9 PELLQDAVLKASVPIPDDFVKVQGIDYSKPEATNMRATDLIEAMKTMGFQASSVGTACEI 68 Query: 71 INNMLKSRAVPLTE----ENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVK 126 I++M R + E E C++E+ + +KT TIF+GYTSN+ISSG+R+T+R+LV+ Sbjct: 69 IDSMRSWRGKHIDELDDHEKKGCFDEEGY--QKT--TIFMGYTSNLISSGVRETLRYLVQ 124 Query: 127 NKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEE 186 +K+VD +VT+AGG+EEDLIKC+APTY+G+F L GK LR +G+NRIGNLLVPNDNYC FEE Sbjct: 125 HKMVDAVVTSAGGVEEDLIKCLAPTYLGEFALKGKSLRDQGMNRIGNLLVPNDNYCKFEE 184 Query: 187 WVTPLLDEMISEQ----MKEGT------------VWSPSRITARLGERINNESSVCYWAW 230 W+ P+LD+M+ EQ K G +W+PS++ R G+ IN+ESSV YWA Sbjct: 185 WIVPILDKMLEEQDEYVKKHGADCLEANQDVDSPIWTPSKMIDRFGKEINDESSVLYWAH 244 Query: 231 RNNIPIFSPALTDGSLGDMMYFHSFKR--PXXXXXXXXXXXXXNTMAVKANNTGVXXXXX 288 +N IPIF P+LTDGS+GDM++FH+FK N+M++ A G+ Sbjct: 245 KNKIPIFCPSLTDGSIGDMLFFHTFKASPKQLRVDIVGDIRKINSMSMAAYRAGMIILGG 304 Query: 289 XXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADA 348 KHHI NA LMRNGADYAVY+NT E+DGSDAGARPDEAVSWGKI+ A VKL+AD Sbjct: 305 GLIKHHIANACLMRNGADYAVYINTGQEYDGSDAGARPDEAVSWGKIKAEAKSVKLFADV 364 Query: 349 TLVFPLIVAQTFA 361 T V PLIVA TFA Sbjct: 365 TTVLPLIVAATFA 377 >UniRef50_P49366-2 Cluster: Isoform Short of P49366 ; n=21; Euteleostomi|Rep: Isoform Short of P49366 - Homo sapiens (Human) Length = 322 Score = 322 bits (791), Expect = 9e-87 Identities = 142/245 (57%), Positives = 192/245 (78%) Query: 14 APNIAVNAVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINN 73 AP A+ AVL+ S LP E+ V GYD+ G +Y +LE++ +GFQATNFG+ V ++N Sbjct: 9 APAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNA 68 Query: 74 MLKSRAVPLTEENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVI 133 M++ + PL+++ + Q + T+CTIFLGYTSN+ISSG+R+TIR+LV++ +VDV+ Sbjct: 69 MIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDVL 128 Query: 134 VTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLD 193 VTTAGG+EEDLIKC+APTY+G+F+L GK LR GINRIGNLLVPN+NYC FE+W+ P+LD Sbjct: 129 VTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFEDWLMPILD 188 Query: 194 EMISEQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFH 253 +M+ EQ EG W+PS++ ARLG+ INN SV YWA +N+IP+FSPALTDGSLGDM++FH Sbjct: 189 QMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGSLGDMIFFH 248 Query: 254 SFKRP 258 S+K P Sbjct: 249 SYKNP 253 Score = 88.2 bits (209), Expect = 3e-16 Identities = 39/49 (79%), Positives = 46/49 (93%) Query: 314 ASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVAQTFAK 362 A EFDGSD+GARPDEAVSWGKIR +A PVK+YADA+LVFPL+VA+TFA+ Sbjct: 262 AQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQ 310 >UniRef50_UPI0000498E3F Cluster: deoxyhypusine synthase; n=1; Entamoeba histolytica HM-1:IMSS|Rep: deoxyhypusine synthase - Entamoeba histolytica HM-1:IMSS Length = 336 Score = 301 bits (739), Expect = 2e-80 Identities = 154/347 (44%), Positives = 205/347 (59%), Gaps = 25/347 (7%) Query: 22 VLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKSRAVP 81 VL S++ E I GYD++NG D+NK++E +GFQA N G + ++N M Sbjct: 15 VLGESKEYKGEKCI--GYDFDNGVDFNKVMEKMKYTGFQALNLGLCIEQVNEM------- 65 Query: 82 LTEENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIE 141 +K + IFLG +SN++SSGLR+ I +LVKNK VD IV TAGGIE Sbjct: 66 ----------------RKNHAKIFLGMSSNIVSSGLREVIHYLVKNKFVDAIVVTAGGIE 109 Query: 142 EDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMK 201 ED IK + PT +GDF GK L G NRIGNL++PN NYC FE+W+ PLL E + EQ + Sbjct: 110 EDFIKTMHPTLLGDFYFKGKELYPNGYNRIGNLILPNSNYCEFEDWMDPLLLECLKEQNE 169 Query: 202 EGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXX 261 G W+PS++ ++GE INNESS+ YWA +NNIP+FSPA+TDGS+GDM++F S+K Sbjct: 170 HGVHWTPSKLVHKMGESINNESSIYYWAAKNNIPVFSPAITDGSIGDMIFFFSYKNEGLV 229 Query: 262 XXXXXXXXXXNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSD 321 + MA A G KHHI NA R G DY ++T+ E D SD Sbjct: 230 LDLVQDVIKIDEMAFNAEKVGCLLVGAGIAKHHILNAMKRRGGCDYCAMLSTSIECDASD 289 Query: 322 AGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVAQTFAKHHFSSK 368 AG+ + G +P NP K+ DAT++ PLIVA TFA+ +K Sbjct: 290 AGSEIAADRTKGFFKPECNPAKVIGDATILLPLIVASTFAQKEEPTK 336 >UniRef50_Q014Q0 Cluster: Deoxyhypusine synthase; n=1; Ostreococcus tauri|Rep: Deoxyhypusine synthase - Ostreococcus tauri Length = 495 Score = 283 bits (695), Expect = 4e-75 Identities = 129/241 (53%), Positives = 183/241 (75%), Gaps = 4/241 (1%) Query: 21 AVLQPSQDLPAETPIVAGYDWENGT-DYNKILESYANSGFQATNFGKTVVEINNMLKSRA 79 AVL S ++P + V GYD++ T DY+ +L+S ++G+QAT+FG+ V E+N ML+ R Sbjct: 252 AVLVKSSEIPEDAVEVRGYDFDAPTTDYDALLQSLLSTGYQATSFGQAVHEVNRMLRWRL 311 Query: 80 VP--LTEENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTA 137 +TEE ++ + D+ ++++T IFLG+TSN+ SSG R+TI++LVKNK+VDV+ TTA Sbjct: 312 SDEAITEE-TEPEDRDEGVRRETRTKIFLGWTSNLTSSGTRETIKYLVKNKMVDVLCTTA 370 Query: 138 GGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMIS 197 GG+EED IKC+ PTY+GDF L G+ LR +G+NRIGNL+ PNDNYC FE+W+ P+LDEM+ Sbjct: 371 GGVEEDFIKCMKPTYLGDFALRGEDLRKKGLNRIGNLIQPNDNYCDFEDWIMPILDEMLR 430 Query: 198 EQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKR 257 EQ +EG W+ S++ RLG IN+E S+ YWA +N+IP + PALTDGS+GDM+YFHS+K Sbjct: 431 EQNEEGVKWTCSKVIKRLGLEINHEDSIFYWAAKNDIPCYCPALTDGSIGDMLYFHSYKN 490 Query: 258 P 258 P Sbjct: 491 P 491 >UniRef50_UPI0000499BAB Cluster: deoxyhypusine synthase; n=1; Entamoeba histolytica HM-1:IMSS|Rep: deoxyhypusine synthase - Entamoeba histolytica HM-1:IMSS Length = 331 Score = 273 bits (669), Expect = 6e-72 Identities = 143/330 (43%), Positives = 206/330 (62%), Gaps = 10/330 (3%) Query: 33 TPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKSRAVPLTEENSDCYEE 92 T + GYD++ G +Y +++ SY +G Q++N G+ + IN ML + P EE + E Sbjct: 2 TTTIKGYDFDKGINYEELVNSYLTTGIQSSNVGRAINIINKMLTWQ--PSEEEKKEYVEG 59 Query: 93 DQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTY 152 D+ +K+ CTI+LG+TS M++SGLRDT R+LV++K VD IVTTAG IE D++KC Sbjct: 60 DERLKR---CTIYLGFTSEMMTSGLRDTFRYLVEHKCVDYIVTTAGAIETDIMKCFGNMN 116 Query: 153 VGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRIT 212 +GDF + K +G R GN+++P + ++W+ + + I E ++PS++ Sbjct: 117 IGDFYM--KPEEVQG-ERHGNMIIPKELIEKTKQWLKEFILD-IQECQDTSMPFTPSQLI 172 Query: 213 ARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMY-FHSFKRPXXXXXXXXXXXXX 271 +GER+N+ +SV WA +NNI IF PALTDG G + + Sbjct: 173 TMMGERLNDTTSVITWAAKNNITIFCPALTDGLFGTCITELNEINPVRLMVDLVQDLRLI 232 Query: 272 NTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVS 331 N+ + + TGV KHHI NANLMRNGAD+AVY+NTA +FDGSDA ARPDEAVS Sbjct: 233 NSSTIHSVETGVIILGGGVMKHHIMNANLMRNGADFAVYINTAGDFDGSDASARPDEAVS 292 Query: 332 WGKIRPNANPVKLYADATLVFPLIVAQTFA 361 WGKI+ ++ VK+ A+A+LVFPLIV++TFA Sbjct: 293 WGKIKIDSENVKVLAEASLVFPLIVSKTFA 322 >UniRef50_Q8SQN2 Cluster: Deoxyhypusine synthase; n=1; Encephalitozoon cuniculi|Rep: Deoxyhypusine synthase - Encephalitozoon cuniculi Length = 362 Score = 259 bits (635), Expect = 7e-68 Identities = 138/328 (42%), Positives = 187/328 (57%), Gaps = 27/328 (8%) Query: 36 VAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKSRAVPLTEENSDCYEEDQF 95 V G D+E D+ I+ S+ GFQ +N + V EI M S+ Sbjct: 52 VRGMDFEKEWDFMAIMRSFETMGFQGSNLYRAVEEIERMKNSK----------------- 94 Query: 96 IKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGD 155 IF G TSN+ISSGLRD I LVK + V V+V T GGIEED+IK PT+ D Sbjct: 95 --------IFFGCTSNIISSGLRDVIATLVKRRHVHVLVITGGGIEEDIIKAFKPTFCAD 146 Query: 156 FNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKE-GTVWSPSRITAR 214 F L G LR G+NRIGNL++P++NY E W+ +++++ E + +PS Sbjct: 147 FRLDGAELRDNGLNRIGNLVIPSENYEHLESWLNNIVNDITEGYTAERPRILTPSSFIRI 206 Query: 215 LGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTM 274 LGERI++ESS+ YWA +N+IP++SPA+ DGSLGD++ FH +R N Sbjct: 207 LGERIDDESSILYWAAKNDIPVYSPAVVDGSLGDILSFHP-RRKMLKLDIVEDVYRINCE 265 Query: 275 AVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGK 334 + T KHHI NANL +NG ++ V +N A EFDGSDAGA DEAVSWGK Sbjct: 266 TIFCGETAAIILGCGVVKHHILNANLFKNGLEHCVLINNAQEFDGSDAGASLDEAVSWGK 325 Query: 335 IRPNANPVKLYADATLVFPLIVAQTFAK 362 ++P VK++ DAT++FPL+V TF + Sbjct: 326 VKPGTRGVKVFGDATILFPLLVGATFMR 353 >UniRef50_O50105 Cluster: Probable deoxyhypusine synthase; n=31; Euryarchaeota|Rep: Probable deoxyhypusine synthase - Pyrococcus horikoshii Length = 342 Score = 243 bits (595), Expect = 5e-63 Identities = 139/347 (40%), Positives = 199/347 (57%), Gaps = 28/347 (8%) Query: 18 AVNAVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKS 77 A + VL+ S+ + E V G ++ +++ Y GFQAT+ G Sbjct: 3 AKDIVLKKSEKI--EGVEVKGPWLDDAQSLEEVVSYYYRIGFQATHLG------------ 48 Query: 78 RAVPLTEENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTA 137 RA+ + + + E + I+ +FLGYTSN+ISSGLR+ I +LVK K VDVIVTTA Sbjct: 49 RAIEIWRKVEEKRERGEEIR------VFLGYTSNIISSGLREIIAWLVKEKKVDVIVTTA 102 Query: 138 GGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMIS 197 GG+EED IK + P +GD+ + LR +G+NRIGN+ VPND Y FE+++ P + ++ Sbjct: 103 GGVEEDFIKSLKPFILGDWEVDDAELRKKGVNRIGNIFVPNDRYIEFEKYMIPFFERVLK 162 Query: 198 EQMKEGTVWSPSRITARLG----ERI--NNESSVCYWAWRNNIPIFSPALTDGSLGDMMY 251 + K + S +G E++ E SV YWA++NNIPIF PA+TDGS+GDM+Y Sbjct: 163 IEEKLSRPLTASEFIYEMGRYMDEKLGKEKEKSVIYWAYKNNIPIFCPAITDGSIGDMLY 222 Query: 252 FHSFKR--PXXXXXXXXXXXXXNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAV 309 F +R N +A+ A T KH I NANL R G DYA+ Sbjct: 223 FFKEERRDSRLIIDIANDIVKLNNLAITAKETASIILGGSLPKHAIINANLFRGGTDYAI 282 Query: 310 YVNTASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIV 356 Y++TA +DGS +GA P E VSWGKI+ A+ V+++ DATL+FP++V Sbjct: 283 YISTAVPWDGSLSGAPPREGVSWGKIKAKADYVEVWGDATLIFPILV 329 >UniRef50_Q9HPX2 Cluster: Probable deoxyhypusine synthase; n=2; Halobacteriaceae|Rep: Probable deoxyhypusine synthase - Halobacterium salinarium (Halobacterium halobium) Length = 330 Score = 215 bits (524), Expect = 2e-54 Identities = 126/342 (36%), Positives = 191/342 (55%), Gaps = 35/342 (10%) Query: 25 PSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKSRAVPLTE 84 P D +TP V GYD+ D+ ++L+SYA +GFQA++ AV +T Sbjct: 15 PGSDEDLDTPDVRGYDFSGEFDFFELLDSYATTGFQASHLAD------------AVDITR 62 Query: 85 ENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDL 144 E ++ + TI+L TSN++SSGLR+ + LV+ VDVI+TT+G + ED+ Sbjct: 63 E-----------MREDDATIYLTLTSNIVSSGLREVVAHLVRENYVDVIITTSGSLTEDI 111 Query: 145 IKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGT 204 IK P +G++++ LR GINR+GN+ VP+D Y EE++ +E ++Q Sbjct: 112 IKTAKPFKMGEWDVDEAALREEGINRLGNIFVPSDRYVWLEEYLYDFFEEFFADQ----K 167 Query: 205 VWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXX 264 V +P+ LG +++E S+ A N+IP+F PALTD +G+ +Y+ +++ Sbjct: 168 VRTPTAFARELGATLDDEDSILKNAADNDIPVFCPALTDAEIGNFLYY--YRQGYDSEVG 225 Query: 265 XXXXXXXNTM---AVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSD 321 + + + A+ TG+ KHH NL R GADYAVY++T E DGS Sbjct: 226 IEILDDYDALIEEGLLADTTGLICVGAGVPKHHAIMTNLFRGGADYAVYISTGMEGDGSL 285 Query: 322 AGARPDEAVSWGKIR-PNANP--VKLYADATLVFPLIVAQTF 360 +GA P+EAVSWGKI+ +A P + A+ATLVFPL+VA F Sbjct: 286 SGAPPEEAVSWGKIKDEDAEPNYALIEAEATLVFPLLVAGAF 327 >UniRef50_Q4QD19 Cluster: Deoxyhypusine synthase, putative; n=5; Trypanosomatidae|Rep: Deoxyhypusine synthase, putative - Leishmania major Length = 379 Score = 197 bits (481), Expect = 3e-49 Identities = 110/263 (41%), Positives = 147/263 (55%), Gaps = 15/263 (5%) Query: 104 IFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGKVL 163 +FL YTSNMIS GLRDT +L + +LVD +++AGGIEED+IKC T +G F L G+ L Sbjct: 109 VFLAYTSNMISCGLRDTFTYLARERLVDCFISSAGGIEEDVIKCGGSTLLGQFGLDGRAL 168 Query: 164 RTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQ--MKEGTVWSPSRITARLGERINN 221 R RGINRIGNLLVPNDNYC FE++ TP+L+ + Q + T +PS +G I Sbjct: 169 RRRGINRIGNLLVPNDNYCWFEDFFTPVLESVQEAQRASRWKTHTAPSEFIEAMGAAIAK 228 Query: 222 E------SSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMA 275 SS+ YW +RN I +FSPA TDGS+GDM+YF++F +A Sbjct: 229 NHPDTCTSSLVYWCYRNGISVFSPAFTDGSMGDMIYFYNFSHKGLVVDPLEDVVRLRKLA 288 Query: 276 VKANNTGVXXXXXXXX-KHHICNANLMRN-GADYAVYVNTASEFDGSDAGARPDEAVSWG 333 K + KHH L+RN D V V T E DG + + V+ G Sbjct: 289 AKEKGRNLAIVLGGGLPKHH-----LLRNVSMDAVVMVTTGLEADGCVSSGVLADDVACG 343 Query: 334 KIRPNANPVKLYADATLVFPLIV 356 +R V++ DAT+VFPL++ Sbjct: 344 LLREETETVRVQGDATVVFPLML 366 >UniRef50_Q8MPC1 Cluster: Putative dexyhypusine synthase; n=1; Taenia solium|Rep: Putative dexyhypusine synthase - Taenia solium (Pork tapeworm) Length = 221 Score = 196 bits (479), Expect = 6e-49 Identities = 95/194 (48%), Positives = 136/194 (70%), Gaps = 6/194 (3%) Query: 20 NAVLQPSQDLPAETPI-VAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKSR 78 +AVL+PSQ LP + V GYD+ G DY +L SYA++GFQAT+F + V +N++++ R Sbjct: 28 DAVLRPSQALPEGVSVEVRGYDFNKGVDYEALLASYASTGFQATHFARAVDVLNSVIERR 87 Query: 79 AVPLTEENSDCYEEDQF----IKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIV 134 +V ++E+ E + I +++ CT+FL YTSNMIS+G+R+ IRFLV++ LVDV+V Sbjct: 88 SVIPSDEDEKSKEVLESLGLGIARRSGCTVFLAYTSNMISAGVREVIRFLVQHNLVDVLV 147 Query: 135 TTAGGIEEDLIKCIAPTYVGDFN-LSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLD 193 T+AGG+EED +KC+A YVGDF+ +G LR GINR GNLLVPN+NY + EEW+ P+ D Sbjct: 148 TSAGGVEEDFVKCMANFYVGDFSRWTGAELRKLGINRTGNLLVPNNNYVILEEWLNPIFD 207 Query: 194 EMISEQMKEGTVWS 207 M+ EQ W+ Sbjct: 208 RMLEEQNTNNVNWT 221 >UniRef50_Q9HL74 Cluster: Probable deoxyhypusine synthase; n=6; Archaea|Rep: Probable deoxyhypusine synthase - Thermoplasma acidophilum Length = 310 Score = 190 bits (464), Expect = 4e-47 Identities = 101/256 (39%), Positives = 153/256 (59%), Gaps = 5/256 (1%) Query: 103 TIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGKV 162 T FL + +++IS+GLR I +VK KLVDVI+TT+G ++ D+ + Y G F+ S Sbjct: 56 TTFLSFPADIISTGLRGLINEVVKRKLVDVIITTSGTLDHDIARTYRNYYCGSFSYSDIE 115 Query: 163 LRTRGINRIGNLLVPNDNYC-LFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINN 221 LR GINR+GN+LVP+++Y + EE V L+++ +++ KE W+ + +G IN+ Sbjct: 116 LRDLGINRLGNVLVPDESYGEIIEEKVMESLEKLYAKK-KE---WATVDLIHEVGLDINS 171 Query: 222 ESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVKANNT 281 ESS+ Y A +NNIP+F P +TDGS G ++ + + + A T Sbjct: 172 ESSIIYNAAKNNIPVFVPGITDGSFGSQLWSFYEQHHDFKINLLEDEHRLSDIIFDAKKT 231 Query: 282 GVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANP 341 G KHH N R+G DYAVYV TA E+DGS +GA+ +EA+SW K+RP+A Sbjct: 232 GAIMIGGGISKHHTIWWNQFRDGLDYAVYVTTAQEYDGSLSGAKLEEAISWKKVRPDARY 291 Query: 342 VKLYADATLVFPLIVA 357 V +Y DAT++ P+++A Sbjct: 292 VNVYGDATVIMPVLLA 307 >UniRef50_Q9GSW0 Cluster: Deoxyhypusine synthase; n=2; Plasmodium falciparum|Rep: Deoxyhypusine synthase - Plasmodium falciparum Length = 496 Score = 187 bits (456), Expect = 4e-46 Identities = 96/222 (43%), Positives = 141/222 (63%), Gaps = 19/222 (8%) Query: 21 AVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNML----- 75 +V S +P +T +V G +++ D ++ + +Y GFQATN G ++ EIN M+ Sbjct: 36 SVFVKSSLIPEKTDVVKGLNFDKEVDLHEFINNYKYMGFQATNLGISIDEINKMIYYKYK 95 Query: 76 --KSRAVPLTEENSDC------YEEDQ------FIKKKTNCTIFLGYTSNMISSGLRDTI 121 ++ P E N +C +DQ + KKK +C I+L +TSNMISSGLR+ Sbjct: 96 DENIKSEPNNENNLNCNNVSEDLNKDQENHLYHYEKKKKSCIIWLSFTSNMISSGLREIF 155 Query: 122 RFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNY 181 +L KNK +DV+VTTAGGIEED+IKC + TY+GDFNL+GK LR +G NRIGNL+VPNDNY Sbjct: 156 VYLAKNKFIDVVVTTAGGIEEDIIKCFSNTYIGDFNLNGKKLRKKGWNRIGNLIVPNDNY 215 Query: 182 CLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINNES 223 C FE+W+ P+L++M+ EQ ++ ++ R + NN++ Sbjct: 216 CKFEDWLQPILNKMLHEQNEKNEQMFLKKLEKRKKKYNNNKN 257 Score = 166 bits (403), Expect = 9e-40 Identities = 79/170 (46%), Positives = 110/170 (64%), Gaps = 5/170 (2%) Query: 207 SPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXX 266 SPS LG+ IN+ESS+ YW ++N+IPIF P LTDGSLGD ++ H++ + Sbjct: 327 SPSEFINTLGKEINDESSLIYWCYKNDIPIFCPGLTDGSLGDNLFLHNYGKKIKNNLILD 386 Query: 267 XXXXX---NTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAG 323 N++A+ +G+ KHH+CNANLMRNGAD+AVYVNTASE+DGSD+G Sbjct: 387 IVKDIKKINSLAMNCEKSGIIILGGGLPKHHVCNANLMRNGADFAVYVNTASEYDGSDSG 446 Query: 324 ARPDEAVSWGKIR--PNANPVKLYADATLVFPLIVAQTFAKHHFSSKKNV 371 A EA+SWGKI+ N VK++ DAT++FPL+V +F + KK++ Sbjct: 447 ANTTEALSWGKIKYGQTNNHVKVFGDATILFPLMVLNSFYLYDQKRKKDM 496 >UniRef50_Q5CHK2 Cluster: Deoxyhypusine synthase; n=1; Cryptosporidium hominis|Rep: Deoxyhypusine synthase - Cryptosporidium hominis Length = 244 Score = 187 bits (456), Expect = 4e-46 Identities = 99/211 (46%), Positives = 134/211 (63%), Gaps = 9/211 (4%) Query: 15 PNIAVNAVLQPSQDLPAETPIVAGYDWENGTDYN--KILESYANSGFQATNFGKTVVEIN 72 P++A N+VL S+ + + V G TD + + GFQATN G+ + EIN Sbjct: 11 PDMAKNSVLLHSEPIDDNSRKVLGPSKNKFTDITIKEYCKDIKKMGFQATNIGRAIDEIN 70 Query: 73 NMLKSRAVPLTEENSDCYEEDQF----IKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNK 128 ML R L++EN + E + + +K CTI+L +TSNMISSGLR+ +L KNK Sbjct: 71 KMLSWR---LSDENIEPDEIEPYNDLEYRKNVKCTIWLSFTSNMISSGLREIFVYLAKNK 127 Query: 129 LVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWV 188 L+DVIVT+AGGIEED IK + T++G+FNL G LR +G NRIGNLLVPN NY FEEW+ Sbjct: 128 LIDVIVTSAGGIEEDFIKVLGSTFLGEFNLKGSELRNKGWNRIGNLLVPNQNYVDFEEWI 187 Query: 189 TPLLDEMISEQMKEGTVWSPSRITARLGERI 219 PL DEM+ Q K+ W+PS++ LGE++ Sbjct: 188 QPLFDEMLEMQNKDSINWTPSKMIHFLGEKL 218 >UniRef50_Q0KHM1 Cluster: Deoxyhypusine synthase; n=5; Plasmodium|Rep: Deoxyhypusine synthase - Plasmodium vivax Length = 455 Score = 186 bits (453), Expect = 8e-46 Identities = 89/194 (45%), Positives = 126/194 (64%), Gaps = 9/194 (4%) Query: 18 AVNAVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKS 77 A ++V S +P T +V G ++E + ++ + Y GFQATN G + E+N M+ Sbjct: 32 AKSSVFVKSNKIPENTDVVKGINFEEEVNLHQFVNQYKYMGFQATNLGIGIDEVNKMIHF 91 Query: 78 RAVPLTEENSDCYEED---------QFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNK 128 + E D ++ D Q + KK C I+L +TSNMISSGLR+ +L K K Sbjct: 92 KYAEGGEGTQDGHDNDHDQDSDDERQALPKKKKCLIWLSFTSNMISSGLREIFVYLAKKK 151 Query: 129 LVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWV 188 +DV+VTTAGG+EED+IKC + TY+GDFNL+GK LR +G NRIGNL+VPNDNYC FE+W+ Sbjct: 152 FIDVVVTTAGGVEEDIIKCFSKTYLGDFNLNGKKLRKKGWNRIGNLIVPNDNYCKFEDWL 211 Query: 189 TPLLDEMISEQMKE 202 PLL++M+ EQ ++ Sbjct: 212 QPLLNKMLHEQNRK 225 Score = 170 bits (414), Expect = 4e-41 Identities = 80/169 (47%), Positives = 109/169 (64%), Gaps = 5/169 (2%) Query: 207 SPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXX 266 SPS +LGE IN+ESS+ YW +N+IP+F P LTDGSLGD ++FH++ + Sbjct: 280 SPSEFIDKLGEEINDESSLIYWCHKNDIPVFCPGLTDGSLGDNLFFHNYGKKIKNNLILD 339 Query: 267 XXXXX---NTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAG 323 N++A+ +G+ KHH+CNANLMRNGAD+AVYVNTA+E+DGSD+G Sbjct: 340 IVKDIKKINSLALNCKKSGIIILGGGLPKHHVCNANLMRNGADFAVYVNTANEYDGSDSG 399 Query: 324 ARPDEAVSWGKIRP--NANPVKLYADATLVFPLIVAQTFAKHHFSSKKN 370 A EA+SWGKI+ N VK++ DAT++FPL+V TF H + N Sbjct: 400 ANTTEALSWGKIKAGHTNNHVKVFGDATILFPLMVLNTFYLHDRGGRHN 448 >UniRef50_Q0J1Q0 Cluster: Os09g0421100 protein; n=5; Oryza sativa|Rep: Os09g0421100 protein - Oryza sativa subsp. japonica (Rice) Length = 309 Score = 185 bits (451), Expect = 1e-45 Identities = 92/173 (53%), Positives = 123/173 (71%), Gaps = 3/173 (1%) Query: 22 VLQPSQDLP-AETPIVAGYDWEN-GTDYNKILESYANSGFQATNFGKTVVEINNMLKSR- 78 VL+PS+ L +AG D+ + G + +L S A +GFQA+N G V +N ML+ R Sbjct: 28 VLKPSESLDEGRFTRIAGADFNDAGLGLSGMLASLATTGFQASNLGDAVDVVNQMLEWRL 87 Query: 79 AVPLTEENSDCYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAG 138 + E+ D E D ++ C IFLG+TSN++SSG+RD +RFLV++ +VDVIVTTAG Sbjct: 88 SHEKPREDCDEPELDPTYRESVKCKIFLGFTSNLVSSGIRDVVRFLVQHHMVDVIVTTAG 147 Query: 139 GIEEDLIKCIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPL 191 GIEEDLIKC+APTY GDF+L G +LR++G+NRIGNLLVPNDNYC FE W+ P+ Sbjct: 148 GIEEDLIKCLAPTYRGDFSLPGTLLRSKGLNRIGNLLVPNDNYCKFENWIMPI 200 Score = 101 bits (242), Expect = 3e-20 Identities = 43/63 (68%), Positives = 51/63 (80%) Query: 281 TGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNAN 340 TG+ KHHICNAN+ RNGAD+AVY+NTA EFDGSD+GA+PDEAVSWGKI+ +A Sbjct: 228 TGIIVLGGGLPKHHICNANMFRNGADFAVYINTAQEFDGSDSGAQPDEAVSWGKIKGSAK 287 Query: 341 PVK 343 PVK Sbjct: 288 PVK 290 >UniRef50_Q12UX5 Cluster: Deoxyhypusine synthase; n=1; Methanococcoides burtonii DSM 6242|Rep: Deoxyhypusine synthase - Methanococcoides burtonii (strain DSM 6242) Length = 324 Score = 180 bits (438), Expect = 5e-44 Identities = 94/264 (35%), Positives = 145/264 (54%), Gaps = 6/264 (2%) Query: 93 DQFIK-KKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPT 151 D +K KK + +FL +TSNM++SGLR L+ + DVIVTT GG+EED++K Sbjct: 37 DVIVKMKKDSAKVFLTFTSNMVTSGLRGFFAQLIDLGVADVIVTTVGGLEEDIMKATGED 96 Query: 152 Y-VGDFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSR 210 + +G F+ L +GINR+GNLL+ ++Y FE V +L E+ +Q + W+ S Sbjct: 97 FQIGSFHTDDVELHEQGINRVGNLLIKTESYMNFESLVDKILKELYEKQNR----WAVSD 152 Query: 211 ITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXX 270 + +G +++ESS+ Y A +NN+PIF PA+TDG+ G +Y + P Sbjct: 153 MLREIGLMLDDESSILYQAAKNNVPIFCPAITDGAFGFHLYLFQQEHPDFIVDVVKDFGN 212 Query: 271 XNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAV 330 + + GV KHH + L+ GA+YAVY+ TA GS +GA +EA Sbjct: 213 ILFASSHDDRKGVIALGGSISKHHAILSTLLNGGAEYAVYMTTAHRTSGSMSGANTNEAK 272 Query: 331 SWGKIRPNANPVKLYADATLVFPL 354 SWGK++ ++ + D ++ FPL Sbjct: 273 SWGKVKDESDVATVIGDVSITFPL 296 >UniRef50_A7DSG5 Cluster: Deoxyhypusine synthase; n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep: Deoxyhypusine synthase - Candidatus Nitrosopumilus maritimus SCM1 Length = 313 Score = 157 bits (381), Expect = 4e-37 Identities = 85/262 (32%), Positives = 132/262 (50%), Gaps = 5/262 (1%) Query: 102 CTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGK 161 C F+ + ++S+GLR ++ ++KNK DV +TT G ++ D+ + + G F + Sbjct: 53 CLKFISFVGAVVSTGLRGILKDMLKNKWFDVAITTCGALDHDIARHFSHYKEGSFTMDDN 112 Query: 162 VLRTRGINRIGNLLVPNDNYC-LFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERIN 220 L + I+R+GN+LVP D+Y L EE + L+E +KE T + I +G+ + Sbjct: 113 ELADQDIHRLGNVLVPMDSYGPLIEEKMQTFLEEEYQNGVKEMTT---AEICKMIGKHLG 169 Query: 221 NESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVKANN 280 E S YWA++N+I + P + DG++G ++ + K + KA Sbjct: 170 -EDSFLYWAYKNHISVVVPGIMDGAVGSQIWLFTQKHNDFKLNMAGDADLLSGYIFKAEK 228 Query: 281 TGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNAN 340 +G KHH N R G DYA Y+ TA EFDGS +GA EA+SWGK+ A Sbjct: 229 SGAFMIGGGISKHHTLWWNQYREGLDYAFYITTAQEFDGSLSGALVREAISWGKVTQKAK 288 Query: 341 PVKLYADATLVFPLIVAQTFAK 362 L+A+ T + P I A K Sbjct: 289 QSTLHAEVTTILPFIYAALVTK 310 >UniRef50_A4YHK6 Cluster: Deoxyhypusine synthase; n=1; Metallosphaera sedula DSM 5348|Rep: Deoxyhypusine synthase - Metallosphaera sedula DSM 5348 Length = 310 Score = 157 bits (380), Expect = 6e-37 Identities = 87/270 (32%), Positives = 139/270 (51%), Gaps = 9/270 (3%) Query: 90 YEEDQFIKK-KTNCTI-FLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKC 147 Y + +K+ + C + F+ +T+N++S+GLR +++ +++VTT G I+ D+ + Sbjct: 40 YRGSRILKRIVSECDLRFISFTANLVSTGLRGLFADMIRRGYFNMVVTTGGTIDHDIARS 99 Query: 148 IAPTYV-GDFNLSGKVLRTRGINRIGNLLVPNDNYC-LFEEWVTPLLDEMISEQMKEGTV 205 Y G F S + LR ++R+GN+L+P ++Y + E V +L ++ E+ + Sbjct: 100 FGGKYYKGSFEFSDEELRKINVHRLGNILIPFEDYGGMVENAVNRILPPLVKEKRE---- 155 Query: 206 WSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXX 265 WS + G+RI ++ S+ A+ N PI P + DGS G ++ S + Sbjct: 156 WSVYELLWEFGKRIEDKHSILRAAYETNTPIIVPGVVDGSFGTNLFIQS-QFTGLRINLF 214 Query: 266 XXXXXXNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGAR 325 + G KHH N R+G DYAVY+ TA EFDGS +GAR Sbjct: 215 EDMRLIKDRVFSSKMAGALLIGGGISKHHTIWWNQFRDGLDYAVYLTTAQEFDGSLSGAR 274 Query: 326 PDEAVSWGKIRPNANPVKLYADATLVFPLI 355 P EA+SW KIR NA +YADATL P++ Sbjct: 275 PREAISWNKIRENAEQAVIYADATLALPIL 304 >UniRef50_Q97ZF1 Cluster: Probable deoxyhypusine synthase; n=7; Thermoprotei|Rep: Probable deoxyhypusine synthase - Sulfolobus solfataricus Length = 312 Score = 155 bits (376), Expect = 2e-36 Identities = 84/255 (32%), Positives = 139/255 (54%), Gaps = 7/255 (2%) Query: 105 FLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYV-GDFNLSGKVL 163 FL +T+N++S+GLR L+K +++VTT G I+ DL + Y G F++ +L Sbjct: 59 FLSFTANLVSTGLRGLFADLIKKGYFNIVVTTGGTIDHDLARSFGGVYYKGSFDIDDTML 118 Query: 164 RTRGINRIGNLLVPNDNYC-LFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINNE 222 + I+R+GN+LVP ++Y + E+ V L E I++ KE + + + G+RI + Sbjct: 119 KDLEIHRLGNVLVPFESYGKVIEDVVRKFLPE-ITKDRKEISAYE---LLWEFGKRITDS 174 Query: 223 SSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVKANNTG 282 +S+ A+ N+PI P + DGS G ++ S + + + +G Sbjct: 175 NSILRAAYDKNVPIIVPGILDGSFGTNLFIQS-QFLNFRINLFEDMRLIKDLIFSSKKSG 233 Query: 283 VXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANPV 342 KHH N ++G +YA+Y+ TA E+DGS +GA+P EA+SW KIRP+A V Sbjct: 234 ALIIGGGISKHHTIWWNQFKDGLNYAIYITTAQEYDGSLSGAKPREAISWNKIRPDAKHV 293 Query: 343 KLYADATLVFPLIVA 357 +Y DAT++ P++ A Sbjct: 294 TIYGDATIIVPILAA 308 >UniRef50_Q4CSD9 Cluster: Deoxyhypusine synthase, putative; n=3; Trypanosoma|Rep: Deoxyhypusine synthase, putative - Trypanosoma cruzi Length = 469 Score = 143 bits (347), Expect = 6e-33 Identities = 72/170 (42%), Positives = 99/170 (58%), Gaps = 3/170 (1%) Query: 192 LDEMISEQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMY 251 L E+ +E ++E + + + R ES+V YWA N +PIFSP+ +DG + + Sbjct: 283 LPELFTEVLRERSGGNMEAVADEAQRRA--ESTVLYWASMNGVPIFSPSFSDGDIMKFIL 340 Query: 252 -FHSFKRPXXXXXXXXXXXXXNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVY 310 N A+++ +G+ KHH+CNANLMRNGAD AV+ Sbjct: 341 DTEDLTTALLKLDLVVDIYRLNKFAMRSQRSGMIILGGGVVKHHVCNANLMRNGADGAVF 400 Query: 311 VNTASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVAQTF 360 +N EFDGSD+GARPDEAVSWGKIR + VK+YA+ +LVFPL+VAQ F Sbjct: 401 INNGQEFDGSDSGARPDEAVSWGKIRLDGESVKVYAEVSLVFPLLVAQVF 450 Score = 49.2 bits (112), Expect = 2e-04 Identities = 39/121 (32%), Positives = 57/121 (47%), Gaps = 8/121 (6%) Query: 17 IAVNAVLQPSQDLPAETPIVAGYDWENGTDYNKI---LESYANSGFQATNFGKTVVEINN 73 +A AVL S D + + + G I LE YA GFQA++F + V Sbjct: 4 LAQKAVLIQSSDTNFQFHALGTVNGPAGDQLQSIAASLEQYAALGFQASHFSQAVAICKR 63 Query: 74 MLK----SRAVPLTEENSDCYEEDQFIKKK-TNCTIFLGYTSNMISSGLRDTIRFLVKNK 128 ML+ S AV ++D +D + + TIFLG T+N+ +G R+ IRFL K Sbjct: 64 MLQPQPPSAAVKQLTGSNDANGKDASLTQVLVQPTIFLGATANLFGTGCREAIRFLCKES 123 Query: 129 L 129 + Sbjct: 124 V 124 >UniRef50_A0RUJ9 Cluster: Deoxyhypusine synthase; n=1; Cenarchaeum symbiosum|Rep: Deoxyhypusine synthase - Cenarchaeum symbiosum Length = 312 Score = 139 bits (336), Expect = 1e-31 Identities = 83/257 (32%), Positives = 126/257 (49%), Gaps = 5/257 (1%) Query: 102 CTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGK 161 C FL + ++S+G R IR ++ K+ DV+VTT G ++ D+ + + G F + Sbjct: 53 CLRFLSFVGALVSTGARGIIRDMLGGKMFDVVVTTCGALDHDIARSYSEYREGSFTMDDS 112 Query: 162 VLRTRGINRIGNLLVPNDNYC-LFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERIN 220 L G++R+G++LVP ++Y L E + L+E E K S + IT +G Sbjct: 113 ELVGAGMHRLGSVLVPLESYGPLIERKMQAFLEE---EYAKGTRRMSTADITRMIGLH-T 168 Query: 221 NESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVKANN 280 E S + A + IP+ P + DG++G ++ + K + + KA Sbjct: 169 GEDSFLHKAAGHGIPVVVPGIMDGAVGSQIWMFTQKHSDFVLDVSADSELLSGLVFKAER 228 Query: 281 TGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNAN 340 +G KHH N R G DYA+Y+ TA E DGS +GA EA+SWGK+ P A Sbjct: 229 SGALMLGGGISKHHTLWWNQYRGGLDYALYMATADEHDGSLSGAPVREAISWGKVAPGAR 288 Query: 341 PVKLYADATLVFPLIVA 357 V L A+ T V P I A Sbjct: 289 QVTLRAEITSVLPFIYA 305 >UniRef50_Q8ZT09 Cluster: Probable deoxyhypusine synthase; n=5; Thermoproteaceae|Rep: Probable deoxyhypusine synthase - Pyrobaculum aerophilum Length = 292 Score = 133 bits (322), Expect = 6e-30 Identities = 78/262 (29%), Positives = 135/262 (51%), Gaps = 19/262 (7%) Query: 105 FLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYV-GDFNLSGKVL 163 FL +T N++++GLR+ I ++ +L +V+VTTAG ++ D+ K + Y G F+L L Sbjct: 37 FLSFTGNLVATGLREFIADAIRRRLFNVVVTTAGALDHDIAKSMGAVYAPGSFDLDDVDL 96 Query: 164 RTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINNE- 222 +G +R+GN+++ + Y PL+++ I ++ +W + T L + E Sbjct: 97 AAKGYHRLGNVVIKKEEY-------GPLVEKFILAHCEK--LWGKTLATYELAYLLGAEL 147 Query: 223 --SSVCYWAWRNNIPIFSPALTDGSLGD-MMYFHSFKRPXXXXXXXXXXXXXNTMAVK-- 277 S+ A R +F P + DG++G +M + R + ++ Sbjct: 148 PEDSILGAAARAGAKVFVPGIVDGAVGTALMTCNDLARTKRGGSRAFIDVLKDEEELREI 207 Query: 278 ---ANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGK 334 + KHH+ + G DY VY++TA E+DGS +GARP EA+SWGK Sbjct: 208 VHNSKKLAALIVGGGISKHHVIWWAQFKGGLDYVVYISTAVEYDGSLSGARPREAISWGK 267 Query: 335 IRPNANPVKLYADATLVFPLIV 356 ++P+A V ++ADATLV P+++ Sbjct: 268 VKPSAKSVFIFADATLVLPVLL 289 >UniRef50_A1RX92 Cluster: Deoxyhypusine synthase; n=1; Thermofilum pendens Hrk 5|Rep: Deoxyhypusine synthase - Thermofilum pendens (strain Hrk 5) Length = 328 Score = 130 bits (313), Expect = 8e-29 Identities = 79/260 (30%), Positives = 128/260 (49%), Gaps = 10/260 (3%) Query: 104 IFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTY-VGDFNLSGKV 162 I + + +N++++GLR I ++ L+D++VTT G + D+ + Y VG F + Sbjct: 62 IAVAFPANLVATGLRGLIADSIRRGLLDLVVTTGGTFDHDIARGTGHKYYVGRFEIDDVF 121 Query: 163 LRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINNE 222 L+ GI+R+GN+L+P +NY E T EM+ E + WSPS + G+R+ +E Sbjct: 122 LKELGIHRLGNILIPVENYGPPIERFT---HEMLEELSALKSSWSPSELAVESGKRLRDE 178 Query: 223 SSVCYWAWRNNIPIFSPALTDGSLGD-MMYFHSFKRPXXXXXXXXXXXXXNTMAV----- 276 S+ + + SP + D + G ++ F+ R + + Sbjct: 179 LSILRAVYEKGRLLVSPGVLDSAFGTAIVTFNDKARASSTARFVELDLISDERRIADYMY 238 Query: 277 KANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIR 336 +A KHH+ R G DYAV + + E+DGS +GAR EAVSWGKI+ Sbjct: 239 EAEKLAGLMLGGGISKHHLIWWAQFRGGLDYAVQITSTPEWDGSLSGARTREAVSWGKIK 298 Query: 337 PNANPVKLYADATLVFPLIV 356 P A V + D T++ PLI+ Sbjct: 299 PEARHVTVPGDVTVILPLIL 318 >UniRef50_Q4Q3H5 Cluster: Deoxyhypusine synthase, putative; n=3; Leishmania|Rep: Deoxyhypusine synthase, putative - Leishmania major Length = 601 Score = 104 bits (250), Expect = 3e-21 Identities = 44/89 (49%), Positives = 60/89 (67%) Query: 272 NTMAVKANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVS 331 N +A+ + TG+ KHH+CNANLMRNGAD+ + +N EFDGSDAGA+P+EA+S Sbjct: 473 NKLAMLSKKTGMLICGGGVVKHHVCNANLMRNGADFTIILNNGQEFDGSDAGAKPEEALS 532 Query: 332 WGKIRPNANPVKLYADATLVFPLIVAQTF 360 WGK+R VK+Y + + PL+VA F Sbjct: 533 WGKVRMEGAFVKVYGEVSTYLPLLVADVF 561 Score = 37.5 bits (83), Expect = 0.56 Identities = 33/123 (26%), Positives = 63/123 (51%), Gaps = 12/123 (9%) Query: 16 NIAVNAVLQPS-QDLPAETPIVAGYDWENGTDYNK-ILESYANSGFQATNFG--KTVVE- 70 NIA +AVL S A + +G D + I+ SY+ GFQATN+G +++ + Sbjct: 3 NIAESAVLVSSASSAQAVAKLTQVQGPTSGFDKAQHIIGSYSTMGFQATNYGLARSIAQR 62 Query: 71 -INNMLKSRAVPLTEEN-----SDCYEEDQFIKKK-TNCTIFLGYTSNMISSGLRDTIRF 123 I S+ + + D E+ + ++++ +F+G ++N++ +G R+ +RF Sbjct: 63 MIRKQPPSKVYQIKDGKYVLVPPDVGEDGRTLQQEHVYPNLFMGVSANLMGTGCREAVRF 122 Query: 124 LVK 126 LV+ Sbjct: 123 LVQ 125 >UniRef50_O26230 Cluster: Probable deoxyhypusine synthase; n=3; Methanobacteriaceae|Rep: Probable deoxyhypusine synthase - Methanobacterium thermoautotrophicum Length = 307 Score = 97.1 bits (231), Expect = 6e-19 Identities = 58/254 (22%), Positives = 113/254 (44%), Gaps = 5/254 (1%) Query: 104 IFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLSGKVL 163 IF+ ++ G+R IR L+ + + ++T+ + DL++ + D+ + L Sbjct: 53 IFMSVAGPLVPGGMRRIIRDLIDDGTISALITSGANLTHDLLEAFGGAHYRDYGFDDEKL 112 Query: 164 RTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINNES 223 GI RIG++ ++++ +FE + + S + S + +G ++++ Sbjct: 113 HQEGIGRIGDVYTRSEDFEVFESENQEIFSSIFSAKPHI----SIQELIHEIGGHLDDDM 168 Query: 224 SVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVKANNTGV 283 S+ A +PI++P L D LG ++ ++ + + + G Sbjct: 169 SIIRTAHLRGVPIYAPGLIDSMLGLQLWMYT-QDNRICLDAVKDMHSLSDLVFSHERIGA 227 Query: 284 XXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANPVK 343 KH+ + L+R G D AV + GS +GA +EA SW K + +N V Sbjct: 228 IILGGGLPKHYTLASTLLRGGVDAAVQITMDRSETGSLSGAPLEEAKSWAKAQAGSNLVT 287 Query: 344 LYADATLVFPLIVA 357 + DAT +FP+I+A Sbjct: 288 VVGDATALFPVILA 301 >UniRef50_Q8PV89 Cluster: Probable deoxyhypusine synthase 1; n=10; Euryarchaeota|Rep: Probable deoxyhypusine synthase 1 - Methanosarcina mazei (Methanosarcina frisia) Length = 317 Score = 97.1 bits (231), Expect = 6e-19 Identities = 65/257 (25%), Positives = 121/257 (47%), Gaps = 9/257 (3%) Query: 103 TIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIA-PTYVGDFNLSGK 161 T F G M +G+R+ I L+++ +DV+VTT + D ++ + Y G + Sbjct: 59 TKFFGLAGAMTPAGMRNIIADLIRDGYIDVLVTTGANMVHDTVEALGLHHYKGSDCANDI 118 Query: 162 VLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINN 221 LR I+RI ++ +P+ ++ EE++ + + E + S ++ +G+ +++ Sbjct: 119 QLRHECIDRIYDVYLPDQHFTDLEEFLQGVYSGLPQENL------SIRQVLTEIGKNLDD 172 Query: 222 ESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVKANNT 281 +SS+ A +P++ PAL D +G + + P + + A + Sbjct: 173 DSSILKTAAEMGVPVYCPALQDSVIGLQAWLYKEGNPLHVDAFADMHEFMD-ICYGAESA 231 Query: 282 GVXXXXXXXXKHHICNANLMR-NGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNAN 340 G K++I + L+ DYA+ + G +GA DEA SWGK+ +A Sbjct: 232 GTMLLGGGVPKNYILQSMLVTPRSFDYAIQLTMDRPETGGLSGATLDEAQSWGKVGEDAK 291 Query: 341 PVKLYADATLVFPLIVA 357 V +YAD+T+ PLIV+ Sbjct: 292 SVTVYADSTITLPLIVS 308 >UniRef50_Q8Q051 Cluster: Probable deoxyhypusine synthase 2; n=8; Euryarchaeota|Rep: Probable deoxyhypusine synthase 2 - Methanosarcina mazei (Methanosarcina frisia) Length = 345 Score = 93.5 bits (222), Expect = 8e-18 Identities = 65/268 (24%), Positives = 126/268 (47%), Gaps = 14/268 (5%) Query: 98 KKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPT-YVGDF 156 K+ + T+ +G + M+ +G+R I +L++ +++D +V+T + D + + YVG Sbjct: 50 KEKDTTVLMGLSGAMVPAGMRRVISYLIRERMIDCLVSTGANLFHDSHEALGRKHYVGSH 109 Query: 157 NLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEM--ISEQMKEGTVWSPSRITAR 214 + + L G++RI ++ + + + + +E+ IS +E ++ + R Sbjct: 110 LANDEKLFEHGVDRIYDVFAVEEEFRNADNLIADFAEEIGEISCSSRE-FMYLLGKELVR 168 Query: 215 LGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTM 274 G E S+ A+R+N+PIF PAL+D S+G + + + Sbjct: 169 RGAA---EDSIVVSAYRHNVPIFVPALSDSSIGIGLTIARRRGLKLEIDQIKDVDEITQI 225 Query: 275 AVKANNTGVXXXXXXXXKHHICNANLMRN-------GADYAVYVNTASEFDGSDAGARPD 327 K+ +TGV K+ I ++ + G +YA+ + S G +G D Sbjct: 226 VEKSGHTGVVYVGGGVPKNFIQQTEVIASILGMDVPGHEYAIQYTSDSPHWGGLSGCTFD 285 Query: 328 EAVSWGKIRPNANPVKLYADATLVFPLI 355 EAVSWGK+ A V+++ DAT+ P++ Sbjct: 286 EAVSWGKVAAQAKKVQVFVDATIALPIV 313 >UniRef50_O28088 Cluster: Probable deoxyhypusine synthase 1; n=1; Archaeoglobus fulgidus|Rep: Probable deoxyhypusine synthase 1 - Archaeoglobus fulgidus Length = 301 Score = 93.1 bits (221), Expect = 1e-17 Identities = 66/260 (25%), Positives = 118/260 (45%), Gaps = 11/260 (4%) Query: 99 KTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTY-VGDFN 157 K++ +FL MI +G+R + +++N + +VTT I ++++ + + +G Sbjct: 43 KSDSFVFLTLAGAMIPAGMRKIVAGMMQNGFISSLVTTGANIVHEIVESLGIGHEIGSCY 102 Query: 158 LSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGE 217 + L INRI ++ V + + EE+++ +++ + +G +++ +G+ Sbjct: 103 VDDTALAEESINRIYDVFVGQEAFERVEEFLSGIIEGL------DG-IYTTYEFLWEVGK 155 Query: 218 RINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVK 277 RI +E S A IP+F P L D G M + R + Sbjct: 156 RIPDERSFLRIAAEREIPVFCPTLHDSIAGLHMTIY---RKNLQIDFFRDVSRIIDFCFQ 212 Query: 278 ANNTGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRP 337 GV K+ A L+ G DYAV + T S G +GA +EA SW K++P Sbjct: 213 KRKMGVIVVGGGVPKNFTLQAMLLAEGFDYAVQITTDSPQWGGLSGATLEEAKSWCKLKP 272 Query: 338 NANPVKLYADATLVFPLIVA 357 +A V +Y DAT+ P++ A Sbjct: 273 DAKAVTVYCDATIALPMLYA 292 >UniRef50_A3DLU9 Cluster: Deoxyhypusine synthase; n=1; Staphylothermus marinus F1|Rep: Deoxyhypusine synthase - Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / F1) Length = 348 Score = 87.0 bits (206), Expect = 7e-16 Identities = 68/275 (24%), Positives = 119/275 (43%), Gaps = 21/275 (7%) Query: 98 KKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYV-GDF 156 +K N TIFLG +M ++G+ I++LV+ ++VDV+++T I ED+ + + Y G Sbjct: 54 RKNNNTIFLGLAGSMSTAGMWKLIKWLVEERIVDVVISTGANISEDIYEAMGNYYYKGSP 113 Query: 157 NLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLG 216 + VL I+R ++ Y E+ L+ E I E + +S G Sbjct: 114 MVDDSVLFKLKIDRFYDVYADELKYREMED----LIREFI-ETLDNNKTYSTMEFLYLFG 168 Query: 217 ERINNESSVCY--WAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTM 274 + ++ + C A+R+ +P+FSPA+ D G + + Sbjct: 169 KYLDEKGIDCIVSAAYRSGVPVFSPAIVDSGYGIASILAKRRGHSIVLDMVKDFEQIVEI 228 Query: 275 AVKANNTGVXXXXXXXXKHHICNANLMR-------------NGADYAVYVNTASEFDGSD 321 ++N K + +M+ G +Y + + T + G Sbjct: 229 GQRSNKLSAIYIGGGVPKDYANLVTVMQMLLAEQEGIGDYNKGFEYIIQITTDAPQWGGL 288 Query: 322 AGARPDEAVSWGKIRPNANPVKLYADATLVFPLIV 356 +GA +EA+SWGK++ NA +Y DAT+ PLIV Sbjct: 289 SGATLEEAISWGKVKSNAKRRTVYVDATIALPLIV 323 >UniRef50_A0B8D8 Cluster: Deoxyhypusine synthase; n=1; Methanosaeta thermophila PT|Rep: Deoxyhypusine synthase - Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrixthermophila (strain DSM 6194 / PT)) Length = 339 Score = 86.6 bits (205), Expect = 9e-16 Identities = 68/262 (25%), Positives = 118/262 (45%), Gaps = 14/262 (5%) Query: 103 TIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPT-YVGDFNLSGK 161 T+FLG M+ +GL++ I +L+ + VD +V+T + DL + + Y G Sbjct: 54 TVFLGLAGAMVPAGLQEMIAYLISRRYVDCLVSTGANLFHDLCEGLGIMHYRGSSCADDA 113 Query: 162 VLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINN 221 L I+RI ++ V +++++ L+ + ++ M +S I LG + Sbjct: 114 HLNECKIDRIFDVFVSEVELHRADKYISDLVMSLRTDIM-----YSSREIMELLGRELP- 167 Query: 222 ESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVKANNT 281 E+++ A+R +PIF PAL+D S+G M ++ K+ T Sbjct: 168 ETTILGAAYRAGVPIFVPALSDSSIGIGMVIAWRNGHRVIVDQIRDVDEITQISEKSAET 227 Query: 282 GVXXXXXXXXKHHICNANLM-------RNGADYAVYVNTASEFDGSDAGARPDEAVSWGK 334 GV K+ I ++ R G YA+ T + G +G EAVSWGK Sbjct: 228 GVVFIGGGVPKNFIQQTKVISELMGTYRGGHSYAIQYTTDTPHFGGLSGCTFSEAVSWGK 287 Query: 335 IRPNANPVKLYADATLVFPLIV 356 + A ++++DAT+ PL+V Sbjct: 288 VDKEARMAQVFSDATITVPLVV 309 >UniRef50_Q18GE0 Cluster: Deoxyhypusine synthase; n=3; Halobacteriaceae|Rep: Deoxyhypusine synthase - Haloquadratum walsbyi (strain DSM 16790) Length = 374 Score = 83.8 bits (198), Expect = 6e-15 Identities = 72/285 (25%), Positives = 122/285 (42%), Gaps = 33/285 (11%) Query: 104 IFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCI-------------AP 150 IF G M+ +G+R I L+++ +D +VTT + D I+ I A Sbjct: 79 IFFGLAGAMVPAGMRQIIVDLIRDGHIDALVTTGANLTHDAIEAIGGKHHHGQAHSSNAS 138 Query: 151 TYVGDFNLSGKV-------------LRTRGINRIGNLLVPNDNYCLFE----EWVTPLLD 193 ++ G + S + LR G++RI N+ +P +++ L E E V P ++ Sbjct: 139 SHDGTNDASEQTHTQTDGTRAHDERLREEGVDRIYNVYLPQEHFALLETHLRENVFPAVE 198 Query: 194 EMISEQMKEGTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFH 253 IS Q + + + I+ + + A+ +++PI+ PA+ D LG + + Sbjct: 199 RQISIQELTAEL-GRANAEKNTQDDIDEDPGIAAAAYNHDVPIYCPAIQDSVLGIQAWVY 257 Query: 254 SFKRPXXXXXXXXXXXXXNTMAVKANNTGVXXXXXXXXKHHICNANLMRNGA-DYAVYVN 312 S + + A A G K+++ L GA DY V + Sbjct: 258 S-QTSSFSLDALDDMTHLSDRAFDAERAGAVVVGGGVPKNYVLQTMLTIPGAYDYGVQLT 316 Query: 313 TASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVA 357 + G +GA DEA SWGK+ P+A + DAT+ PL+VA Sbjct: 317 MDPDATGGLSGATLDEARSWGKLEPSAANATVLGDATITLPLLVA 361 >UniRef50_A7H9T8 Cluster: Deoxyhypusine synthase; n=2; Bacteria|Rep: Deoxyhypusine synthase - Anaeromyxobacter sp. Fw109-5 Length = 390 Score = 82.2 bits (194), Expect = 2e-14 Identities = 66/278 (23%), Positives = 124/278 (44%), Gaps = 19/278 (6%) Query: 100 TNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCI-APTYVGDFNL 158 ++ TI L T M +GL I+ +++ VD+++ T + DL + P G F++ Sbjct: 60 SDATIALTVTGAMAPAGLGGAIQAMIEAGFVDLVIATGANLYHDLHFALKLPVVQGHFHV 119 Query: 159 SGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGER 218 K L GI RI ++ + D+ + +V L++ + + G + +P ++ LG+ Sbjct: 120 DDKELYQAGIERIYDVFITEDSLLDTDAFVREALEK--APKSLRGHISTP-QLHHYLGQL 176 Query: 219 INNESSVCYWAW-----RNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNT 273 +N ++ + +W R ++PIF+ + D S+G + + Sbjct: 177 VNQQAPLPEKSWVATAARYDVPIFTSSPGDSSIGMNVAAMKLRGGETTVDPDLDVLQSTA 236 Query: 274 MAVKANNTGVXXXXXXXXKHHICNA--------NLMRNGADYAVYVNTASEFDGSDAGAR 325 + A GV K+ +L R G +Y + ++T S G +GA Sbjct: 237 IVYDAKVNGVVILGGGSPKNFYLQTQPTLWQILDLNRGGHEYVLQISTDSPQWGGLSGAT 296 Query: 326 PDEAVSWGKIRPN--ANPVKLYADATLVFPLIVAQTFA 361 P EA+SWGK++ N N V +Y+D T+ P++ + A Sbjct: 297 PSEAISWGKVQANMMKNHVVVYSDTTIAAPVVFSYALA 334 >UniRef50_Q8TXD7 Cluster: Probable deoxyhypusine synthase; n=1; Methanopyrus kandleri|Rep: Probable deoxyhypusine synthase - Methanopyrus kandleri Length = 297 Score = 81.8 bits (193), Expect = 3e-14 Identities = 58/257 (22%), Positives = 108/257 (42%), Gaps = 19/257 (7%) Query: 103 TIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYV--GDFNLSG 160 T+ L ++ GL + L++ LVD ++T+ + D + + +V G+ N+ G Sbjct: 49 TVLLTVAGPAVAGGLGELFERLIREGLVDAVITSGANVVHDALDALGGIHVCLGERNVDG 108 Query: 161 KVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERIN 220 R+ + +P + + FE ++ +L ++ +W +G+R+ Sbjct: 109 -------YGRVHDTHIPTEAFEKFEHFMREVLSDLSGRVSCRELLWE-------MGKRL- 153 Query: 221 NESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTMAVKANN 280 ES A +PI+SP + D +G ++ HS + + +A Sbjct: 154 -ESGFLRAAADEGVPIYSPGILDSMVGLHVWIHSQDHDFHLDLVDDMHHLAD-LVFEAEE 211 Query: 281 TGVXXXXXXXXKHHICNANLMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNAN 340 G KH A ++R G DYAV + GS +GA +E SW K+R +A Sbjct: 212 LGAIILGGSVPKHFAMGAAMLRGGLDYAVQITMDRPETGSLSGAPLEEGKSWEKVREDAE 271 Query: 341 PVKLYADATLVFPLIVA 357 + D ++FPL+ + Sbjct: 272 VATIVGDYLIIFPLLAS 288 >UniRef50_UPI000065F1C0 Cluster: Deoxyhypusine synthase (EC 2.5.1.46) (DHS).; n=1; Takifugu rubripes|Rep: Deoxyhypusine synthase (EC 2.5.1.46) (DHS). - Takifugu rubripes Length = 163 Score = 81.4 bits (192), Expect = 3e-14 Identities = 30/56 (53%), Positives = 44/56 (78%) Query: 203 GTVWSPSRITARLGERINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRP 258 G W+PS++ R G+ IN+ SVCYWA++N+IP+FSPALTDG++GD++Y S + P Sbjct: 1 GVHWTPSKVIQRFGKEINHPESVCYWAYKNDIPVFSPALTDGAIGDVLYLFSVENP 56 Score = 72.1 bits (169), Expect = 2e-11 Identities = 30/43 (69%), Positives = 38/43 (88%) Query: 301 MRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANPVK 343 ++ GAD+AVYVNTA E DGSD+GA+PDEAV+WGKI+ +A PVK Sbjct: 121 LKKGADFAVYVNTAQEADGSDSGAKPDEAVTWGKIKMDAKPVK 163 >UniRef50_Q9AB72 Cluster: Deoxyhypusine synthase-like protein; n=27; Bacteria|Rep: Deoxyhypusine synthase-like protein - Caulobacter crescentus (Caulobacter vibrioides) Length = 367 Score = 64.5 bits (150), Expect = 4e-09 Identities = 61/275 (22%), Positives = 111/275 (40%), Gaps = 20/275 (7%) Query: 102 CTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEE-DLIKCIA-PTYVGDFNLS 159 C+ +L + + G R +VKN ++D +V T I + D + + Y + Sbjct: 78 CSTWLILAGSTSAGGCMHVYRDMVKNGMIDAVVATGASIVDMDFFEALGFKHYQAAGPVD 137 Query: 160 GKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGT-VWSPSRITARLGER 218 VLR I+RI + + + + + + +++ +W + A + Sbjct: 138 DNVLRDNYIDRIYDTYIDEEELQACDHTILEICNKLEPRGYSSREFIWEMGKWLAEGNAK 197 Query: 219 INNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFH-----SFKRPXXXXXXXXXXXXXNT 273 E S+ A+ +PIF PA D S G + H + K+P Sbjct: 198 --KEGSLIQTAYEEGVPIFCPAFVDSSAGFGLVKHQKEKIAEKKPYLMIDAVADFRELTD 255 Query: 274 MAVKANNTGVXXXXXXXXKHH-----ICNANLMRNGAD---YAVYVNTASEFDGSDAGAR 325 + + A TG+ K+ +C A ++ AD YA+ + A DG+ + + Sbjct: 256 VKIAAGTTGLFMVGGGVPKNFAQDTVVC-AEILGVEADMHKYAIQITVADVRDGACSSST 314 Query: 326 PDEAVSWGKIRPNANPVKLYADATLVFPLIVAQTF 360 EA SWGK+ + ++A+AT V PLI + + Sbjct: 315 LKEAASWGKVSTTYEQM-VFAEATTVVPLIASDAY 348 >UniRef50_A6C8I9 Cluster: Deoxyhypusine synthase; n=1; Planctomyces maris DSM 8797|Rep: Deoxyhypusine synthase - Planctomyces maris DSM 8797 Length = 362 Score = 58.4 bits (135), Expect = 3e-07 Identities = 44/156 (28%), Positives = 69/156 (44%), Gaps = 8/156 (5%) Query: 96 IKKKTNCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPT-YVG 154 + K TNC + L + M + I ++ LV +V T I L + I Y Sbjct: 56 MSKDTNCKVVLTLSGAMTVAKQGSIICDMIDRGLVHAVVATGALIAHGLTESIGLVHYQY 115 Query: 155 DFNLSGKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITAR 214 + N S + L +G NRI + L N E L+ ++ E E VWS +R+ Sbjct: 116 NPNDSDETLYKKGYNRIYDTLEMESNLNNVER----LVRSVLRESKPEDGVWSSARLCRA 171 Query: 215 LGERINNESS---VCYWAWRNNIPIFSPALTDGSLG 247 LG+R++ + A+ N+P+F PA TD +G Sbjct: 172 LGQRLSEVDEGRGILRSAYEQNVPVFIPAFTDSEIG 207 Score = 34.3 bits (75), Expect = 5.2 Identities = 19/47 (40%), Positives = 26/47 (55%), Gaps = 3/47 (6%) Query: 319 GSDAGARPDEAVSWGK-IRPNANP--VKLYADATLVFPLIVAQTFAK 362 G +G E VSWGK I P ++Y+DAT+V PL++ F K Sbjct: 311 GGLSGCTYSEGVSWGKFISPQEGGRFAEVYSDATVVLPLLMKAVFEK 357 >UniRef50_A0RU78 Cluster: Deoxyhypusine synthase; n=5; Crenarchaeota|Rep: Deoxyhypusine synthase - Cenarchaeum symbiosum Length = 353 Score = 48.8 bits (111), Expect = 2e-04 Identities = 58/270 (21%), Positives = 106/270 (39%), Gaps = 19/270 (7%) Query: 101 NCTIFLGYTSNMISSGLRDTIRFLVKNKLVDVIVTTAGGI-EEDLIKCIAPTYVGDFNLS 159 + TI L + + G + L++ LVD I+TT + ED P G + Sbjct: 34 DATICLTISGALTPVGFGGIFKELIERGLVDWIITTGANVYHEDHFAWGLPVRQGHHEVD 93 Query: 160 GKVLRTRGINRIGNLLVPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGE-- 217 L +GI RI ++ + E+ + + M +++ + + S +GE Sbjct: 94 DMQLYDKGIVRIRDVFIKFYETLEVEDQI---MQRMFRDRLLDSSFTSAEFCNV-IGEIS 149 Query: 218 ---RINNESSVCYWAWRNNIPIFSPALTDGSLGDMMYFHSFKRPXXXXXXXXXXXXXNTM 274 + E S A + ++P++ L D SL + H + + Sbjct: 150 SAKAPHPERSFVAAAHKYDVPVYVSTLKDSSLALNLAVHRLRGKEHSLDFVREILEQAAI 209 Query: 275 AVKANNTGVXXXXXXXXKHH------ICNANLMRN--GADYAVYVNTASEFDGSDAGARP 326 + +G+ K+ + + L R+ G DY + V A G +GA Sbjct: 210 VHGSKKSGIVELGGGVPKNAAQQTGPLLDQILRRDHGGQDYIIQVTDARPDTGGLSGATL 269 Query: 327 DEAVSWGKIR-PNANPVKLYADATLVFPLI 355 E SWGK++ + V +Y+DAT+ FP++ Sbjct: 270 QEGKSWGKVQDAHEGMVTVYSDATIAFPIM 299 >UniRef50_Q3KTG9 Cluster: SJCHGC07653 protein; n=1; Schistosoma japonicum|Rep: SJCHGC07653 protein - Schistosoma japonicum (Blood fluke) Length = 94 Score = 47.6 bits (108), Expect = 5e-04 Identities = 19/31 (61%), Positives = 26/31 (83%) Query: 102 CTIFLGYTSNMISSGLRDTIRFLVKNKLVDV 132 CTIFL YTSNM+SSG+R+ IRFL ++ L+ + Sbjct: 34 CTIFLAYTSNMVSSGVREVIRFLAEHNLLHI 64 >UniRef50_Q8DKP1 Cluster: Deoxyhypusine synthase-like protein; n=6; Cyanobacteria|Rep: Deoxyhypusine synthase-like protein - Synechococcus elongatus (Thermosynechococcus elongatus) Length = 401 Score = 47.2 bits (107), Expect = 7e-04 Identities = 23/60 (38%), Positives = 32/60 (53%), Gaps = 2/60 (3%) Query: 300 LMRNGADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNA--NPVKLYADATLVFPLIVA 357 L G DY + + A G +GA P EAVSWGK+ P + V Y D+T+ P++ A Sbjct: 283 LEERGHDYFIQITDARPDTGGLSGAVPSEAVSWGKVDPQGLRDTVVCYTDSTIALPILTA 342 >UniRef50_Q1IQA7 Cluster: Deoxyhypusine synthase; n=1; Acidobacteria bacterium Ellin345|Rep: Deoxyhypusine synthase - Acidobacteria bacterium (strain Ellin345) Length = 357 Score = 42.3 bits (95), Expect = 0.020 Identities = 35/136 (25%), Positives = 63/136 (46%), Gaps = 5/136 (3%) Query: 124 LVKNKLVDVIVTTAGGIEEDLIKCIAPT-YVGDFNLSGKVLRTRGINRIGNLLVPNDNYC 182 LV +V IV+T + L++ + +V D ++ L G NR+ + L P N Sbjct: 94 LVDAGIVKTIVSTGALMAHGLVEAAGKSHFVYDEKMNDVELYEAGYNRVYDTLEPETNLN 153 Query: 183 LFEEWVTPLLDEMISEQMKEGTVWSPSRITAR-LGERINNESSVCYWAWRNNIPIFSPAL 241 E V +L++ ++++ + +R R L E + + A+ N+P+F PA Sbjct: 154 FVEGIVAKILEKWDADEVM--CSYKLNREIGRYLHEHVAGRG-ILKSAFEKNVPVFVPAF 210 Query: 242 TDGSLGDMMYFHSFKR 257 TD +G + H+ KR Sbjct: 211 TDSEMGLDVALHNRKR 226 >UniRef50_Q2JJ35 Cluster: Deoxyhypusine synthase family protein; n=28; Bacteria|Rep: Deoxyhypusine synthase family protein - Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacteriumYellowstone B-Prime) Length = 336 Score = 38.3 bits (85), Expect = 0.32 Identities = 18/51 (35%), Positives = 31/51 (60%) Query: 307 YAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIVA 357 Y ++ ++ GS +GA P+E ++WGK+ + + +DAT+V PLI A Sbjct: 281 YFCQISDSTTSYGSYSGAVPNEKITWGKLGIDTPKFVIESDATIVAPLIFA 331 Score = 33.5 bits (73), Expect = 9.1 Identities = 36/145 (24%), Positives = 58/145 (40%), Gaps = 18/145 (12%) Query: 124 LVKNKLVDVIVTTAGGIEEDLIKCIA-------PTYVGDFNLSGKVLRTRGINRIGNLLV 176 +++ V I T +EED+ IA P Y + L R +NR+ + + Sbjct: 70 MIRQGKVHAISCTGANLEEDIFNLIAHEFYERVPHYRDLSPQQEQELLERHLNRVTDTCI 129 Query: 177 PNDNY------CLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGE--RINNESSVCYW 228 P + L EEW++ D+ ++ R + RL +IN S Y Sbjct: 130 PEEEAMRRLEKALLEEWIST--DQAGERYFPHEFLYRILR-SGRLEPYYQINPRDSWVYA 186 Query: 229 AWRNNIPIFSPALTDGSLGDMMYFH 253 A N+PI+ P D + G+M H Sbjct: 187 AMEANLPIYVPGWEDSTTGNMYAAH 211 >UniRef50_Q8RBX9 Cluster: Putative uncharacterized protein; n=6; Thermoanaerobacter|Rep: Putative uncharacterized protein - Thermoanaerobacter tengcongensis Length = 103 Score = 37.5 bits (83), Expect = 0.56 Identities = 21/65 (32%), Positives = 29/65 (44%), Gaps = 3/65 (4%) Query: 28 DLPAETPIV---AGYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKSRAVPLTE 84 +LP PIV W T Y +IL SY G A +F ++++N K + E Sbjct: 23 ELPVIVPIVLYNGSRKWTAKTSYKEILNSYETFGEYAVDFKYILIDVNRYTKGGVIEAGE 82 Query: 85 ENSDC 89 NS C Sbjct: 83 FNSVC 87 >UniRef50_Q20103 Cluster: Putative uncharacterized protein; n=3; Caenorhabditis|Rep: Putative uncharacterized protein - Caenorhabditis elegans Length = 334 Score = 36.7 bits (81), Expect = 0.97 Identities = 20/58 (34%), Positives = 33/58 (56%), Gaps = 2/58 (3%) Query: 168 INRIGNLL--VPNDNYCLFEEWVTPLLDEMISEQMKEGTVWSPSRITARLGERINNES 223 INR+ NL +P C+ +EW+TP++ + ++ K G+V S T +L R N+S Sbjct: 153 INRLANLSGSIPFLEKCIPQEWLTPIVLQASVDEKKRGSVDSAEEATEKLVVRSLNDS 210 >UniRef50_A0LN06 Cluster: Deoxyhypusine synthase; n=1; Syntrophobacter fumaroxidans MPOB|Rep: Deoxyhypusine synthase - Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) Length = 345 Score = 35.9 bits (79), Expect = 1.7 Identities = 15/49 (30%), Positives = 31/49 (63%) Query: 307 YAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLI 355 Y ++ ++ GS +GA P+E ++WGK+ ++ + +DA++V PL+ Sbjct: 275 YFCQISDSTTSYGSYSGAVPNEKITWGKLDVDSPRFIIESDASIVLPLV 323 >UniRef50_Q09DI8 Cluster: Cardb domain protein; n=3; Bacteria|Rep: Cardb domain protein - Stigmatella aurantiaca DW4/3-1 Length = 1152 Score = 35.5 bits (78), Expect = 2.2 Identities = 20/86 (23%), Positives = 41/86 (47%), Gaps = 4/86 (4%) Query: 38 GYDWENGTDYNKILESYANSGFQATNFGKTVVEINNMLKSRAVPLTEENSDCYEEDQFIK 97 G ++ NGT +++ NS F+ T V N +K R+V + +N Q + Sbjct: 936 GINFSNGTRNSRVF----NSSFRTTGDDSLAVWANPYVKDRSVDIAHDNQFVNNTIQLVW 991 Query: 98 KKTNCTIFLGYTSNMISSGLRDTIRF 123 + I+ GY +++ ++ + DT+ + Sbjct: 992 RANGIAIYGGYNNSIENNLIYDTMNY 1017 >UniRef50_Q09A08 Cluster: Deoxyhypusine synthase; n=3; Cystobacterineae|Rep: Deoxyhypusine synthase - Stigmatella aurantiaca DW4/3-1 Length = 346 Score = 34.7 bits (76), Expect = 3.9 Identities = 15/50 (30%), Positives = 29/50 (58%) Query: 307 YAVYVNTASEFDGSDAGARPDEAVSWGKIRPNANPVKLYADATLVFPLIV 356 Y ++ ++ GS +GA P+E ++W K+ + +DAT+V PL++ Sbjct: 274 YFCQISDSTTSYGSYSGATPNEKITWDKLTETTPMFVIESDATIVAPLML 323 >UniRef50_Q9FLA5 Cluster: Gb|AAC61825.1; n=3; core eudicotyledons|Rep: Gb|AAC61825.1 - Arabidopsis thaliana (Mouse-ear cress) Length = 443 Score = 34.3 bits (75), Expect = 5.2 Identities = 19/86 (22%), Positives = 42/86 (48%), Gaps = 2/86 (2%) Query: 49 KILESYANSGFQATNFGKTVVEINNMLKSRAVPLTEENSDCYEEDQFIKKKTNCTIFLGY 108 ++++ N+ T+F + + +++K +P + D YE + +K++TN F+G Sbjct: 196 RVMDRVKNAVLLVTDFDRLRADQGSLVKDVIIPYSHR-IDAYEGELGVKQRTNLLFFMGN 254 Query: 109 TSNMISSGLRDTIRFLVKNKLVDVIV 134 +RD + F + K DV++ Sbjct: 255 RYRKDGGKVRDLL-FKLLEKEEDVVI 279 >UniRef50_Q9PQB4 Cluster: DNA polymerase III polC-type; n=1; Ureaplasma parvum|Rep: DNA polymerase III polC-type - Ureaplasma parvum (Ureaplasma urealyticum biotype 1) Length = 1442 Score = 34.3 bits (75), Expect = 5.2 Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 4/71 (5%) Query: 69 VEINNMLKSRAVPLTEENSDCYEEDQFIKKKTNCTIFLGYTSNMIS----SGLRDTIRFL 124 + ++NM KS VP+ + C ED+ +KK+ + L + + M S ++ I F Sbjct: 288 IVLDNMSKSGQVPIGKIKKICCVEDKHVKKQITPRLELNFHTKMSSLDAIISTQELIDFA 347 Query: 125 VKNKLVDVIVT 135 VKN+L + +T Sbjct: 348 VKNQLKTIGIT 358 >UniRef50_Q9U0N4 Cluster: ABC transporter, putative; n=2; Plasmodium|Rep: ABC transporter, putative - Plasmodium falciparum (isolate 3D7) Length = 1822 Score = 33.9 bits (74), Expect = 6.9 Identities = 25/131 (19%), Positives = 58/131 (44%), Gaps = 5/131 (3%) Query: 52 ESYANSGFQATNFGKTVVEINNMLKSRAVPLTEENSDCYEEDQFIKKKTNCTIFLGYTSN 111 +S + + +++ + E N+ S ++ E + + +++I K NC+ L Y + Sbjct: 610 KSNSTYNYNSSHIHEKKEEYENIHNSSNSTMSNEFKEKKKNNEYIIKLENCSFGLSYDNK 669 Query: 112 MISSGLRDTIRFLVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGDFNLS-GKVLRTRGINR 170 + + I F +K + +I+ G + I +GDFN++ G + + Sbjct: 670 CDNDHILKNINFNLKRNSLAIIIGNVGSGKSAFFHSI----LGDFNMTHGNLYIENFFKK 725 Query: 171 IGNLLVPNDNY 181 + L VP +++ Sbjct: 726 MPILYVPQNSW 736 >UniRef50_Q4S833 Cluster: Chromosome 9 SCAF14710, whole genome shotgun sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 9 SCAF14710, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 848 Score = 33.5 bits (73), Expect = 9.1 Identities = 28/120 (23%), Positives = 53/120 (44%), Gaps = 10/120 (8%) Query: 66 KTVVEINNMLKSRAVPLTEENSDCYEEDQ--FIKKKTNCTIFLGYTSNMISSGLRDTIRF 123 + +V++ K V N D Q FI+K N I L YT +++SS ++ Sbjct: 191 QVIVKLLQYFKWHWVAFLYSNDDYGANAQKLFIEKIKNTDICLAYTHDLVSSDFLSIFQW 250 Query: 124 LVKNKLVDVIVTTAGGIEEDLIKCIAPTYVGD--------FNLSGKVLRTRGINRIGNLL 175 + K+V ++V + L+K V D ++L+ ++ + +GI IG ++ Sbjct: 251 IKSQKIVVIVVMAPEWSAKPLVKSAIQHNVTDKVWIAGEAWSLNKELPKEKGIKHIGTVI 310 >UniRef50_Q029V5 Cluster: Deoxyhypusine synthase; n=1; Solibacter usitatus Ellin6076|Rep: Deoxyhypusine synthase - Solibacter usitatus (strain Ellin6076) Length = 427 Score = 33.5 bits (73), Expect = 9.1 Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 3/56 (5%) Query: 304 GADYAVYVNTASEFDGSDAGARPDEAVSWGKIRPNA---NPVKLYADATLVFPLIV 356 G + V + TA DGS + P EAV+WGK+ + + +D +LV P +V Sbjct: 298 GYAFDVQIVTAPVTDGSLSSCPPAEAVTWGKVDKDTYLQTTESMQSDYSLVMPFLV 353 >UniRef50_A4QSG6 Cluster: Putative uncharacterized protein; n=1; Magnaporthe grisea|Rep: Putative uncharacterized protein - Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) Length = 310 Score = 33.5 bits (73), Expect = 9.1 Identities = 44/187 (23%), Positives = 67/187 (35%), Gaps = 10/187 (5%) Query: 4 PCNVEKPVKVAPNIAVNAVLQPSQDLPAETPIVAGYDWENGTDYNKILESYANSGFQATN 63 P + KP AP A P P P G TD + QA Sbjct: 129 PSSPPKPTSAAPKPTGAAATSPGGAKPTAPPRAGGGGMVPATDPKPFGTGSIKATIQAAV 188 Query: 64 FGKTVVEINNMLKSRAVPLTEENSD-CYEEDQFIKKKTNCTIFLGYTSNMISSGLRDTIR 122 + +++N L ++AV L + +D +QF K N + SN + + + Sbjct: 189 LDQVSAQVSNGL-AQAVKLVTDVADWTRAREQFTKTTVNAM----WESNTDKAAYKGAVC 243 Query: 123 FLVKNKLVDVIVTTAGGIEEDLIK-CIAPTYVGDFNLSGKVLRTRGINRIGNLLVPNDNY 181 + KL D AG DL+K + Y + + G V R +G NL + Sbjct: 244 YNAAFKL-DRPELIAGQTSVDLVKGALKTNYNCFYMMPGNVFRAQGDGGFINLATAGN-- 300 Query: 182 CLFEEWV 188 C F + V Sbjct: 301 CKFTDKV 307 Database: uniref50 Posted date: Oct 5, 2007 11:19 AM Number of letters in database: 575,637,011 Number of sequences in database: 1,657,284 Lambda K H 0.317 0.133 0.403 Gapped Lambda K H 0.279 0.0580 0.190 Matrix: BLOSUM62 Gap Penalties: Existence: 9, Extension: 2 Number of Hits to DB: 406,096,121 Number of Sequences: 1657284 Number of extensions: 16629289 Number of successful extensions: 35429 Number of sequences better than 10.0: 58 Number of HSP's better than 10.0 without gapping: 46 Number of HSP's successfully gapped in prelim test: 12 Number of HSP's that attempted gapping in prelim test: 35282 Number of HSP's gapped (non-prelim): 84 length of query: 371 length of database: 575,637,011 effective HSP length: 102 effective length of query: 269 effective length of database: 406,594,043 effective search space: 109373797567 effective search space used: 109373797567 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 37 (14.9 bits) X3: 62 (25.0 bits) S1: 41 (21.7 bits) S2: 73 (33.5 bits)
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